blood_and_immune_upper_slim
has part
has part
has_part
lacks_plasma_membrane_part
has plasma membrane part
develops from
develops from
capable of
capable of
has high plasma membrane amount
mast cell
FMA:66784
A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
BTO:0000830
histaminocyte
labrocyte
mastocyte
CALOHA:TS-0603
tissue basophil
Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.
myeloid leukocyte
mast cell progenitor
histamine secreting cell
histamine production involved in inflammatory response
prostaglandin production involved in inflammatory response
positive regulation of peripheral tolerance induction
positive regulation of leukocyte chemotaxis
positive regulation of type 2 immune response
secretory granule
heparin biosynthetic process
Homo sapiens
C-C chemokine receptor type 3
interleukin-3 receptor class 2 alpha chain
mast/stem cell growth factor receptor
cell surface glycoprotein CD200 receptor 3
high affinity immunoglobulin epsilon receptor subunit alpha
protein-containing material entity