part_of
part of
part of
has part
has part
has_part
overlaps
overlaps
only in taxon
develops from
develops from
contributes to morphology of
produces
produces
site_of
hepatic immune response
glycogen biosynthetic process
glycogen catabolic process
Vertebrata <vertebrates>
Homo sapiens
abdomen
endocrine system
digestive system
bile
liver
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_F_Liver.glb
https://ccf-ontology.hubmapconsortium.org/objects/v1.2/VH_M_Liver.glb
https://upload.wikimedia.org/wikipedia/commons/6/64/Leber_Schaf.jpg
EV:0100089
Organ which secretes bile and participates in formation of certain blood proteins.[AAO]
BTO:0000759
MAT:0000097
TAO:0000123
EHDAA2:0000997
secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
EFO:0000887
An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
galen:Liver
hepatic
GAID:288
MESH:D008099
The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates.
Wikipedia:Liver
VHOG:0000257
MA:0000358
NCIT:C12392
EHDAA:2197
MIAA:0000097
uberon
All vertebrates possess a liver (reference 1); Later in craniate evolution, an anterior gill arch was transformed into jaws, and many new types of feeding subsequently evolved.(...) A liver evolved that, among its many functions, stores considerable energy as glycogen or lipid (reference 2).[well established][VHOG]
FMA:7197
AAO:0010111
SCTID:181268008
An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver. The zebrafish liver differs from the mammalian liver in that the hepatocytes are not clearly organized in cords or lobules and the typical portal triads are not apparent. In addition, the zebrafish liver does not have Kuppfer cells. Furthermore, a clear distinction can be made between the male and female liver in the adult zebrafish. The female hepatocytes are very basophilic (Figure 15c) as a result of the production of vitellogenin (Van der Ven et al. 2003).
CALOHA:TS-0564
Only ZFA considers this part_of immune system - we weaken this to an overlaps relation, as in general it's only a subset of cells that have clear immune function.
iecur
EMAPA:16846
ZFA:0000123
relationship type change: differentiates_from endoderm (AAO:0000139) CHANGED TO: develops_from endoderm (UBERON:0000925)[AAO]
XAO:0000133
UBERON:0002107
jecur
UMLS:C0023884
exocrine system
exocrine gland
immune system
hepatobiliary system
liver primordium
endoderm-derived structure
septum transversum
liver lobule
abdomen element
digestive system gland
liver bud
hepatopancreas