has role
protective antigen role
protective antigen
Leishmania donovani protein
GRP-78
protein
BALB/c mice were immunized with a vaccine expressing the 78kDa (GRP-78) antigen of Leishmania donovani. Challenge infection was given intracardially after 2 weeks of second booster. A significant decrease in parasite burden was seen in vaccinees over the infected controls on all post challenge days and was found that maximum protection was provided by 78kDa+rIL-12 vaccine. It was highly immunogenic as depicted by the reduction in parasite load (71-94.8%) [PubMed: 20093205].
Protegen ID: 561; NCBI Protein GI: 16797868; NCBITaxon: 5661
YH, ZX