part of part of develops from capable of enteroendocrine cell insulin secreting cell type B pancreatic cell https://cdn.humanatlas.io/digital-objects/2d-ftu/pancreas-islets-langerhans/v1.2/assets/2d-ftu-pancreas-islets-langerhans.png pancreatic islet core type B enteroendocrine cell pancreatic B cell A cell that secretes insulin and is located towards the center of the islets of Langerhans. B-cell of pancreatic islet beta cell islet EV:0200009 ZFA:0009102 pancreatic B-cell BTO:0000783 Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. https://cellxgene.cziscience.com/cellguide/CL_0000169 pancreatic beta cell MA:0002419 beta cell of pancreatic islet insulin-secreting cell FMA:70586 ncithesaurus:Beta_Cell Type B pancreatic cells, also known as beta cells, are one of the endocrine cell types located in the pancreas. They represent 70-80% of the cells in the islets of Langerhans, the endocrine part of this organ. Unique to mammals, Type B pancreatic cells are the predominant cell type in the pancreatic islets (50–80% of all islet endocrine cells) and play a crucial role in the body's metabolic regulation and glucose homeostasis. The primary function of type B pancreatic cells is the production, storage, and release of insulin, accounting for almost all insulin production in the human body: each cell contains about 20 pg insulin. Insulin has a critical function in regulating blood sugar levels: whenever glucose levels in the blood are high, such as after a meal, type B pancreatic cells secrete insulin to promote glucose uptake into cells, transforming it into usable energy or storing it for later use. Additionally, insulin also inhibits glucose production by the liver, therefore lowering blood glucose levels. Impaired function of the type B cells is associated with type 1 and type 2 diabetes, metabolic diseases characterized by chronic hyperglycemia. In type 1 diabetes, an autoimmune response leads to the attack of the body’s own type B cells, resulting in the insufficient production and secretion of insulin. In type 2 diabetes, insulin resistance occurs, and type B cells are unable to compensate by producing more insulin. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) beta cell progenitor cell of endocrine pancreas pancreatic endocrine cell insulin secretion Homo sapiens islet of Langerhans