has part lacks_plasma_membrane_part has characteristic capable of mononuclear phagocyte professional antigen presenting cell dendritic cell BTO:0002042 CALOHA:TS-0194 MESH:D003713 ZFA:0009209 Dendritic cells, named for their tree-like extensions called dendrites, are a type of immune cell that form a critical bridge between the innate and adaptive immune systems. They are derived from hematopoietic bone marrow progenitor cells and can be found throughout the body poised as sentinels in locations such as the skin, lungs, or liver, as well as immune organs such as the thymus, lymph nodes, or spleen. They can also be found in an immature state in the blood. Dendritic cells serve as antigen-presenting cells, with a primary function of processing and presenting antigens to T-cells to facilitate an immune response. Upon encountering an antigen, dendritic cells engulf the pathogen via phagocytosis and subsequently process the pathogen into antigens. These antigens are then presented on the surface of the dendritic cell in the context of major histocompatibility complex (MHC) molecules. The dendritic cell migrates to the lymph nodes, containing naive T-cells, and presents the antigens to them. This process triggers the activation of cognate T-cells into effector T-cells, which can then recognize and eradicate cells bearing the same antigen. Additionally, the dendritic cells can influence the type of immune response the body will mount. They communicate with T-cells through the use of co-stimulatory molecules and cytokines. Depending on the type of co-stimulatory molecules used and the set of cytokines released, dendritic cells can promote the development of a cellular immune response, dominated by cytotoxic T cells effective against intracellular pathogens such as viruses, a humoral response, mediated by B cells and effective against extracellular bacteria and toxins, or a tolerogenic response. Thus, dendritic cells play a pivotal role in immunity, helping the body to effectively combat infections, prevent autoimmune diseases, and maintain tolerance to healthy self-tissues. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative). interdigitating cell https://cellxgene.cziscience.com/cellguide/CL_0000451 FMA:83036 veiled cell lymphocyte leukocyte cytokine production antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation MHC class II protein complex regulation of T cell differentiation Homo sapiens mononucleate CD19 molecule CD34 molecule CD3 epsilon neural cell adhesion molecule 1 membrane-spanning 4-domains subfamily A member 1