blood_and_immune_upper_slim has characteristic develops from capable of mononuclear phagocyte promonocyte monocyte ZFA:0009265 Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. https://cellxgene.cziscience.com/cellguide/CL_0000576 BTO:0000876 Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells. FMA:62864 CALOHA:TS-0638 Monocytes are a type of white blood cell that constitute part of the mononuclear phagocyte system. They feature prominently in the human body's first line of defense against foreign substances as a part of the innate immune system. Monocytes are the largest of all circulating leukocytes and are identified by their bean-shaped nucleus. They are produced in the bone marrow and circulate in the bloodstream; in some conditions, they may enter tissues and differentiate into macrophages or dendritic cells or a distinct monocyte-derived cell. Monocytes function effectively as phagocytes, devouring harmful pathogens in the body. They engulf and destroy microbes, foreign substances, cancer cells, and other materials detrimental to the body's well-being. This process, known as phagocytosis, is vital for the body's immune response. Monocytes are also equipped to identify harmful pathogens and alert other immune cells to their presence. This is achieved by producing proinflammatory cytokines that recruit other immune cells to the affected area, amplifying the immune response. Beyond their role in fighting infections, monocytes play an important role in the repair and healing of tissues. After an infection or inflammation subsides, monocytes can transition into different types of cells and assist in healing by clearing dead cells and debris and facilitating tissue regeneration. They are crucial in wound healing, control of microbial growth, and tissue development. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) myeloid leukocyte progenitor cell macrophage differentiation osteoclast differentiation myeloid dendritic cell differentiation Homo sapiens mononucleate