capable of has characterizing marker set NS forest marker set of pulmonary alveolar type 1 cell (Human lung). squamous epithelial cell pulmonary alveolar epithelial cell pulmonary alveolar type 1 cell 2010-06-23T04:37:54Z pulmonary alveolar type I cell type 1 pneumocyte type I alveolar epithelial cells membranous pneumocytes A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. type I alveolar cells ATI AT1 https://cdn.humanatlas.io/digital-objects/2d-ftu/lung-pulmonary-alveolus/v1.3/assets/2d-ftu-lung-pulmonary-alveolus.png type 1 alveolar epithelial cells https://cellxgene.cziscience.com/cellguide/CL_0002062 BTO:0000780 type I pneumocyte Type I pneumocytes, also known as alveolar epithelial cells type I, are specialized cells lining the alveoli within the lungs. Their strategic positioning within the air sacs of the lungs plays a crucial role in gaseous exchange. They cover around 90-95% of the alveolar surface, yet make up only about 40% of the total number of cells in the alveolus. Their unique squamous, or flattened, shape allows for a vast surface area that enables a fast rate of diffusion of respiratory gases, oxygen and carbon dioxide. Functionally, type I pneumocytes serve as the site for the critical exchange of gases between the air in the lungs and the blood in the capillaries. These cells are in direct contact with pulmonary capillaries and are therefore primarily responsible for oxygen passing into the bloodstream and carbon dioxide being removed from the bloodstream. It is important to note that these cells are extremely thin and fragile, a feature that promotes easy passage of gases but also renders the cells susceptible to damage. A unique critical feature of type I pneumocytes is their inability to divide and proliferate. Should damage to these cells occur, repair and replenishment is addressed through the conversion of another cell type, known as type II pneumocytes, into type I pneumocytes. The role of type I cells is thus highly specific, and strictly aligned with enabling efficient respiration - an essential process for all aerobic organisms. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) FMA:62500 The marker set AGER can identify the Human cell type pulmonary alveolar type 1 cell in the lung with a confidence of 0.85 (NS-Forest FBeta value). squamous alveolar lining cell lung type 1 cells small alveolar cells squamous alveolar cell respiratory gaseous exchange by respiratory system Homo sapiens