has plasma membrane part capable of myeloid dendritic cell plasmacytoid dendritic cell CD141-positive myeloid dendritic cell 2010-10-04T02:38:58Z A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta. https://cellxgene.cziscience.com/cellguide/CL_0002394 Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8-alpha-positive DCs. CD141-positive myeloid dendritic cells represent one of the conventional myeloid dendritic cell subsets, which have been categorized based upon their expression of the cell surface markers CD1c and CD141. However, these markers have limitations as both may be expressed on multiple cell types. The more commonly accepted nomenclature of these cell types is conventional dendritic cell 1 (cDC1) for CD141+ dendritic cells and conventional dendritic cell 2 (cDC2) for CD1c+ dendritic cells. cDC1 cells are defined by high expression of the transcription factor IRF8 in addition to cell surface markers such as CD141, CLEC9A, and XCR1, although the expression levels of different markers can vary across dendritic cells found in different tissues. cDC1 cells are relatively rare compared to cDC2 cells. Dendritic cells are responsible for sensing antigens and presenting them to cells of the adaptive immune response to activate them. cDC1 appear to primarily perform antigen cross-presentation, in which antigens derived from the extracellular environment may also be presented in the context of MHC I molecules, while typically intracellular antigens are presented in the context of MHC I molecules. cDC1 can also secrete a range of cytokines, including type III interferons, to further direct the immune response. cDC1s are thus important for antitumor immunity and in viral and bacterial infections. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) positive regulation of T-helper 1 type immune response type I interferon production antigen processing and presentation of exogenous peptide antigen via MHC class I Homo sapiens thrombomodulin