has plasma membrane part capable of myeloid dendritic cell CD1c-positive myeloid dendritic cell 2010-10-04T02:39:01Z CD1c-positive myeloid dendritic cells represent one of the conventional myeloid dendritic cell subsets, which have been categorized based upon their expression of the cell surface markers CD1c and CD141. However, these markers have limitations as both may be expressed on multiple cell types. The more commonly accepted nomenclature of these cell types is conventional dendritic cell 1 (cDC1) for CD141+ dendritic cells and conventional dendritic cell 2 (cDC2) for CD1c+ dendritic cells. cDC2 cells are defined by high expression of the transcription factor IRF4 in addition to cell surface markers such as CD1c, CD11c, CD11b, and SIRPA, although the expression levels of different markers can vary across dendritic cells found in different tissues. cDC2 cells are the predominant population of myeloid or conventional dendritic cells in the body. They can be further subclassified into DC2 and DC3 cells, although the functional differences of these subsets are not well characterized. Dendritic cells are responsible for sensing antigens and presenting them to cells of the adaptive immune response to activate them. cDC2 cells can present glycolipid antigens in addition to protein antigens. cDC2 may also perform antigen cross-presentation, in which antigens derived from the extracellular environment may also be presented in the context of MHC I molecules, while typically intracellular antigens are presented in the context of MHC I molecules. cDC2 can also secrete a range of cytokines, such as IL-12, tumor necrosis factor-alpha, and IL-10, to further direct the immune response. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) https://cellxgene.cziscience.com/cellguide/CL_0002399 Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. A myeloid dendritic cell that is CD1c-positive. interleukin-8 production Homo sapiens T-cell surface glycoprotein CD1c