kidney_upper_slim part of part of endothelial cell capillary endothelial cell kidney blood vessel cell kidney capillary endothelial cell KUPO:0001030 Kidney capillary endothelial cells form the innermost lining of the capillaries and microvessels within kidneys, including those lining the glomerular capillaries and the vasa recta. Each cell exhibits a unique array of adhesion molecules, receptors, and secreted mediators which interact with circulating blood cells and solutes. One of the key functions of kidney capillary endothelial cells is enabling filtration, reabsorption, secretion, and excretion – the crucial steps in the formation of urine. In the glomerulus, these cells form a collaborative relationship with the podocytes to constitute the glomerular filtration barrier; here, the ultra-thin endothelial cells create a wall through which water and small solutes pass while retaining larger proteins and molecules within the bloodstream. This permits the rapid and selective filtration of plasma, a primary aspect of the kidney's role in waste clearance and fluid, electrolyte, and acid-base homeostasis. Kidney capillary endothelial cells also conduct multiple homeostatic roles, such as vasomotor control, fibrinolysis, platelet adhesion, inflammation, and coagulation. They also play a crucial role in responding to renal injury by participating in fibrogenesis, an initial response following acute kidney injury. The endothelial cells spearhead angiogenesis (new blood vessel formation) and the repair and regeneration of renal tissue, thereby enhancing the survival function of the kidney itself. Furthermore, factors secreted by kidney capillary endothelial cells also help control the growth and differentiation of other types of renal cells. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) An endothelial cell that is part of the capillary of the kidney. https://cellxgene.cziscience.com/cellguide/CL_1000892 kidney capillary