part_of
part of
part of
has plasma membrane part
develops from
develops from
capable of
capable of
stem cell
glial cell
microglial cell
A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.
FMA:54539
BTO:0000078
MF.microglia.CNS
Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
hortega cells
brain-resident macrophage
BTO:0000962
brain macrophage
microglia
microgliocyte
mesodermal cell
central nervous system macrophage
innate immune response
Homo sapiens
integrin alpha-M
adhesion G protein-coupled receptor E1
macrosialin
protein-containing material entity
central nervous system
yolk sac