lacks_plasma_membrane_part
has plasma membrane part
develops from
develops from
DN3 thymocyte
DN4 thymocyte
early cortical thymocyte
T.DN4.th
DN4 immature T-cell
DN4 cell
DN4 alpha-beta immature T-lymphocyte
A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.
DN4 immature T cell
Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.
double negative 4
DN4 alpha-beta immature T lymphocyte
thymocyte
double negative thymocyte
pre-T cell receptor complex
CD4 molecule
CD44 molecule
interleukin-2 receptor subunit alpha
T cell receptor co-receptor CD8