has_role
chemical entity
antineoplastic agent
(-)-demecolcine
(-)-colchamine
(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
0
371.17327
371.42690
A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.
C21H25NO5
CAS:477-30-5
CHEBI:4393
CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(OC)c(=O)cc12
Colcemid
Drug_Central:4375
InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
KEGG:C11250
KNApSAcK:C00027138
LINCS:LSM-6590
N-deacetyl-N-methylcolchicine
N-desacetyl-N-methylcolchicine
N-methyl-N-deacetylcolchicine
N-methyl-N-desacetylcolchicine
NNJPGOLRFBJNIW-HNNXBMFYSA-N
PMID:1061646
PMID:20082301
PMID:22394737
PMID:2329167
PMID:2977921
PMID:7237451
PMID:7720099
PMID:7887202
Patent:DE936268
Reichstein's F
Santavy's substance F
Wikipedia:Demecolcine
chebi_ontology
demecolcina
demecolcine
demecolcinum
Reaxys:2822892
ChEMBL:238150
CiteXplore:22394737
CiteXplore:20082301
CiteXplore:2329167
CiteXplore:2977921
NCIt:C419
CiteXplore:7720099
ChemIDplus:477-30-5
MeSH:D003703
CiteXplore:7237451
KEGG COMPOUND:477-30-5
CiteXplore:7887202
CiteXplore:1061646
KEGG COMPOUND:C11250