part of has part transcription cis-regulatory region binding DNA-binding transcription factor activity https://github.com/geneontology/go-ontology/issues/15704 https://github.com/geneontology/go-ontology/issues/16534 https://github.com/geneontology/go-ontology/issues/20253 Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions. GO:0001199 GO:0001131 molecular_function transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding GO:0001151 GO:0001130 gene-specific transcription factor activity GO:0001071 transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding krc bacterial-type DNA binding transcription factor activity transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding Reactome:R-HSA-163666 2010-10-21T04:37:54Z bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity metal ion regulated sequence-specific DNA binding transcription factor activity transcription factor activity sequence-specific DNA binding transcription factor activity GO:0001204 sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity GO:0000130 transcription factor activity, metal ion regulated sequence-specific DNA binding nucleic acid binding transcription factor activity DNA binding transcription factor activity metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding GO:0003700 regulation of DNA-templated transcription transcription regulator activity