JAK Inhibitor INCB047986
753081
753081
753081
An orally bioavailable inhibitor of Janus-associated kinases (JAK), with potential antineoplastic activity. Upon oral administration, INCB047986 specifically binds to and inhibits the phosphorylation of JAK, which affects JAK-dependent signaling and may lead to an inhibition of cellular proliferation in JAK-overexpressing tumor cells. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
C111761
CL454148
GDC
INCB 047986
INCB-047986
INCB047986
JAK Inhibitor INCB047986
JAK Inhibitor INCB047986
JAK Inhibitor INCB047986
Pharmacologic Substance
NCIt Antineoplastic Agent Terminology
GDC Terminology
GDC Therapeutic Agent Terminology
JAK Inhibitor
NCI Drug Dictionary Terminology
GDC Value Terminology
Pharmacologic Substance