2-Ethylhydrazide
2-Ethylhydrazide
2-Ethylhydrazide
2-Ethylhydrazide
A podophyllic acid derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, 2-ethylhydrazide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.
C0066615
C1165
GDC
Organic Chemical
Pharmacologic Substance
_2-Ethylhydrazide
NCIt Antineoplastic Agent Terminology
Epipodophyllotoxin Compound
GDC Terminology
GDC Therapeutic Agent Terminology
GDC Value Terminology
Pharmacologic Substance