CTRP Terminology
CTRP Agent Terminology
8-Chloroadenosine
34408-14-5
8-CHLOROADENOSINE
8-Chloro-adenosine
8-Chloroadenosine
8-Chloroadenosine
8-Chloroadenosine
8-Cl-Ado
8-Cl-adenosine
810651
Adenosine, 8-Chloro-
An antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-ATP), which functions as a ribonucleoside analogue and competes with ATP during transcription. Therefore, this agent causes RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis.
C0169868
C124047
CTRP
FDA
PA05MFH3I7
Pharmacologic Substance
NCIt Antineoplastic Agent Terminology
Purine Antagonist
NCI Drug Dictionary Terminology
Differentiation Inducer
FDA Established Names and Unique Ingredient Identifier Codes Terminology