Gene_Product_Has_Chemical_Classification
Gene_Product_Has_Organism_Source
Gene_Product_Has_Associated_Anatomy
Gene_Product_Has_Structural_Domain_Or_Motif
Gene_Product_Has_Biochemical_Function
Gene_Product_Plays_Role_In_Biological_Process
CTRP Terminology
Cytoplasm
Ankyrin Repeat
Human
CTRP Biomarker Terminology
CTRP Molecular Genetic Biomarker Terminology
Phosphoprotein
Signal Transduction
I Kappa B
A family of proteins that bind to the nuclear localization signal (NLS) domains of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) transcription factor complexes. This sequesters NF-kappaB in the cytoplasm and prevents its binding to the activation domains of target genes in the nucleus. Phosphorylation of I kappa B proteins, which is catalyzed by cytokine-activated I kappa B kinases (IKBK; IKK), disrupts binding to NF-kappaB and induces the degradation of I kappa B; this allows NF-kappaB to enter the nucleus and activate the transcription of target genes.
Amino Acid, Peptide, or Protein
C0167954
C17583
CTRP
I Kappa B
I Kappa B
I Kappa B
I kappa B proteins have an N-terminal regulatory domain, followed by six or more ankyrin repeats and a PEST domain near their C terminus.
I-Kappa-B
I-Kappa-B_Protein
IKB
IKappaB
IkappaB
Inhibitor of Kappa B
NF-Kappa B Inhibitor
NF-Kappa-B Inhibitor
NFKB Inhibitor
NFKBI
Nuclear Factor Kappa-B Inhibitor
Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor
Protein-Protein Interaction
Signaling Protein
Protein Family
Inflammatory Response