Gene_Product_Is_Element_In_Pathway
Gene_Product_Expressed_In_Tissue
Gene_Product_Plays_Role_In_Biological_Process
Gene_Product_Encoded_By_Gene
Brain
Neuron
Dopamine Receptor
Neuronal Transmission
DRD5 Gene
D(1B) Dopamine Receptor
126453
Amino Acid, Peptide, or Protein
C1529472
C26122
D(1B) Dopamine Receptor
D(1B) Dopamine Receptor
D(1B) dopamine receptor (477 aa, ~53 kDa) is encoded by the human DRD5 gene. This protein plays a role in dopaminergic synaptic transmission and adenylate cyclase activation.
D(5) Dopamine Receptor
D1Beta Dopamine Receptor
DBDR
DRD1B
DRD1L2
DRD5
Dopamine D5 Receptor
Dopamine Receptor D1B
Dopamine Receptor D5
Dopamine Receptor D5, encoded by the human DRD5 gene, is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. This receptor complexes selectively with GABA-A ligand-gated channel through the direct binding of its carboxy-terminal domain with the second intracellular loop of the GABA-A gamma-2 (short) receptor subunit. This physical association enables mutual inhibitory functional interactions between these receptor systems. Pseudogenes related to this gene reside on chromosomes 1 and 2. Defects in DRD5 are a cause of blepharospasm, a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age.
Dopamine_Receptor-D5
P21918
Receptor
Neuroactive Ligand-Receptor Signaling Pathway
Calcium-Mediated Signaling Pathway