Gene_Product_Is_Element_In_Pathway
Gene_Product_Has_Organism_Source
Gene_Product_Malfunction_Associated_With_Disease
Gene_Product_Expressed_In_Tissue
Gene_Product_Has_Structural_Domain_Or_Motif
Gene_Product_Plays_Role_In_Biological_Process
Gene_Product_Encoded_By_Gene
B-Lymphocyte
SH2 Domain
Proline-Rich Domain
Human
Signal Transduction
Adaptor Signaling Protein
BLNK Gene
B-Cell Linker Protein
604515
Amino Acid, Peptide, or Protein
B Cell Adaptor Containing SH2 Domain
B Cell Linker Protein
B Cell-Specific Adaptor Protein
B-Cell Adapter Containing a SH2 Domain Protein
B-Cell Adapter Containing a Src Homology 2 Domain Protein
B-Cell Linker
B-Cell Linker Protein
B-Cell Linker Protein
B-Cell_Linker
B-cell linker protein (456 aa, ~50 kDa) is encoded by the human BLNK gene. This protein is involved in co-localizing the B-cell receptor and its downstream signaling targets.
B-cell linker protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins. Tyrosine phosphorylation of B-cell linker protein by SYK provides docking sites for these SH2-containing effector molecules that, in turn, permits the phosphorylation and/or activation of their respective signaling pathways.
BLNK
C1740182
C26636
Cytoplasmic Adapter Protein
Q8WV28
SH2 Domain-Containing Leukocyte Protein, 65-kD
SLP-65
Src Homology 2 Domain-Containing Leukocyte Protein of 65 kDa
Src Homology [SH2] Domain-Containing Leukocyte Protein of 65 kD
B-Cell Differentiation
BCR Signaling Pathway
Childhood B Acute Lymphoblastic Leukemia
B Cell Receptor Signaling Pathway
Primary Immunodeficiency Pathway