Molecular_Abnormality_Involves_Gene
RARA Gene
ZBTB16 Gene
Fusion Protein Expression
ZBTB16-RARA Fusion Protein Expression
A fusion protein encoded by a t(15;17) translocation, which involves the human genes ZBTB16 and RARA and is characteristic of acute promyelocytic leukemia. It is a transcriptional repressor with both gain-of-function and dominant-negative properties, resulting in transcriptional repression of retinoic acid and non-retinoic acid target genes and culminating in differentiation arrest.
C1518796
C37220
Cell or Molecular Dysfunction
PLZF-RARalpha Fusion Protein Expression
PLZF-RARalpha_Fusion_Protein_Expression
PLZF/RARA Fusion Protein Expression
ZBTB16-RARA Fusion Protein Expression
ZBTB16-RARA Fusion Protein Expression
ZBTB16/RARA Fusion Protein Expression
ZBTB16/RARA Fusion Gene