Gene_Product_Is_Element_In_Pathway
Gene_Product_Has_Associated_Anatomy
Gene_Product_Has_Structural_Domain_Or_Motif
Gene_Product_Has_Biochemical_Function
Gene_Product_Plays_Role_In_Biological_Process
Gene_Product_Encoded_By_Gene
Mitotic Chromosome
SET Domain
Methyltransferase
Chromatin Remodeling Factor
Chromatin Remodeling
Protein Methylation
Gene Regulation Process
Lysine Degradation Pathway
KMT5A Gene
N-Lysine Methyltransferase KMT5A
607240
Amino Acid, Peptide, or Protein
C1173804
C73697
EC 2.1.1.43
Enzyme
H4-K20-HMTase KMT5A
H4-K20-HMTase SETD8
H4-K20-Specific Histone Methyltransferase
Histone H4-Lysine 20-Specific Methyltransferase
Histone-Lysine N-Methyltransferase KMT5A
Histone-Lysine N-Methyltransferase SETD8
Histone-Lysine_N-Methyltransferase_SETD8
KMT5A
Lysine N-Methyltransferase 5A
Lysine-Specific Methylase 5A
N-Lysine Methyltransferase KMT5A
N-Lysine Methyltransferase KMT5A
N-Lysine Methyltransferase SETD8
N-lysine methyltransferase KMT5A (393aa, ~43 kDa) is encoded by the human KMT5A gene. This protein plays a role in the methylation of histones and other proteins.
N-lysine methyltransferase KMT5A specifically monomethylates the lysine at amino acid residue 20 of histone H4 (H4K20me1) and the lysine at amino acid residue 382 of cellular tumor antigen p53 (p53K382). H4K20me1 is enriched during mitosis and is a biomarker for epigenetic transcriptional repression. p53K382 leads to the repression of p53-dependent gene expression.
PR-Set7
PR/SET Domain Containing Protein 8
PR/SET Domain-Containing Protein 07
PR/SET07
PR/SET7
Q9NQR1
SET Domain-Containing Protein 8
p53 Pathway for Transcriptional Regulation