CTRP Terminology
CTRP Agent Terminology
JAK2 Inhibitor
NCIt Antineoplastic Agent Terminology
GDC Terminology
GDC Therapeutic Agent Terminology
NCI Drug Dictionary Terminology
GDC Value Terminology
Pharmacologic Substance
Tyrosine-Protein Kinase JAK2
FDA Established Names and Unique Ingredient Identifier Codes Terminology
JAK2 Inhibitor AZD1480
672901
672901
672901
935666-88-9
AZD-1480
AZD1480
An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.
C2745423
C91394
CTRP
FDA
GDC
JAK2 Inhibitor AZD1480
JAK2 Inhibitor AZD1480
JAK2 Inhibitor AZD1480
JAK2 Inhibitor AZD1480
KL2Z2TLF01
Pharmacologic Substance