has part
has part
has_part
intracellular signal transduction
NIK/NF-kappaB signaling
p52-dependent NF-kappaB signaling
NIK/NF-kappaB cascade
non-canonical NF-KB signaling
NIK/NF-kappaB signal transduction
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
GO:0038061
noncanonical NF-kappaB signaling
noncanonical nuclear factor kappaB (NF-kappaB) pathway
bf
biological_process
2012-01-16T05:44:46Z
positive regulation of NF-kappaB transcription factor activity