Term IRI	Term label	Parent term IRI	Parent term label	Alternative term	Definition
http://purl.obolibrary.org/obo/HP_0025372	Loud snoring	http://purl.obolibrary.org/obo/HP_0025267	Snoring		Snoring at a particularly loud or abnormally high volume.
http://purl.obolibrary.org/obo/HP_0025374	Duplicated odontoid process	http://purl.obolibrary.org/obo/HP_0003310	Abnormal odontoid process morphology		The presence of two distinct odontoid processes. The odontoid process, also known as the dens of the axis, is a protuberance of the C2 vertebral body around which the first vertebra rotates.
http://purl.obolibrary.org/obo/HP_0025375	Orthotopic os odontoideum	http://purl.obolibrary.org/obo/HP_0005667	Os odontoideum		Os odontoideum is classified into two anatomic types (orthotopic and dystopic). Os odontoideum is defined as an ossicle that consists of smooth and separate caudal portions of the odontoid process.With dystopic os odontoideum, the ossicle is located near the basion or is fused with the clivus.
http://purl.obolibrary.org/obo/HP_0025376	Hyperglutaminuria	http://purl.obolibrary.org/obo/HP_0033093	Increased glutamine family amino acid level in urine		An increased concentration of glutamine in the urine.
http://purl.obolibrary.org/obo/HP_0025377	Triggered by exertion	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exertion or physical exercise.
http://purl.obolibrary.org/obo/HP_0030915	Cerebellar edema	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		Swelling from fluid accumulation (serous fluid infiltration into the interstitial space) in the cerebellum.
http://purl.obolibrary.org/obo/HP_0030957	Ventricular septal aneurysm	http://purl.obolibrary.org/obo/HP_0010438	Abnormal ventricular septum morphology		A bowing (bulging to one side) of the interventricular septum of more than 15 mm on either side in adults and 5 mm in children during normal cardiac motion.
http://purl.obolibrary.org/obo/HP_0030958	Membranous ventricular septal aneurysm	http://purl.obolibrary.org/obo/HP_0030957	Ventricular septal aneurysm		Bowing (bulging out) of the membranous part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle).
http://purl.obolibrary.org/obo/HP_0030959	Muscular ventricular septal aneurysm	http://purl.obolibrary.org/obo/HP_0030957	Ventricular septal aneurysm		Bowing (bulging out) of the muscular part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle).
http://purl.obolibrary.org/obo/HP_0040288	Nasogastric tube feeding	http://purl.obolibrary.org/obo/HP_0033454	Tube feeding		The condition of inability to eat normally treated by placement of a thin tube through the nose into the stomach that is then used to carry food.
http://purl.obolibrary.org/obo/HP_0040289	Cyclically decreased total neutrophil count	http://purl.obolibrary.org/obo/HP_0001875	Decreased total neutrophil count		Abnormal decrease of the absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group, which occurs cyclically and then recovers without intervention.
http://purl.obolibrary.org/obo/HP_0040296	Abnormal location of the eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		Anomalous anatomical placement of the eyebrow.
http://purl.obolibrary.org/obo/HP_0040300	Abnormal circulating free fatty acid concentration	http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration		Any deviation from the normal concentration of a free fatty acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0040301	Increased urinary glycerol	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increased concentration of glycerol in the urine.
http://purl.obolibrary.org/obo/HP_0040302	Elevated circulating glycerol concentration	http://purl.obolibrary.org/obo/HP_0031795	Abnormal circulating glycerol level		The concentration of glycerol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0040303	Decreased circulating iron concentration	http://purl.obolibrary.org/obo/HP_0040130	Abnormal circulating iron concentration		The concentration of iron cation in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0040305	Increased male libido	http://purl.obolibrary.org/obo/HP_0046503	Increased libido		Increased desire for sexual activity on the part of a male.
http://purl.obolibrary.org/obo/HP_0040306	Decreased male libido	http://purl.obolibrary.org/obo/HP_0046504	Decreased libido		Reduced desire for sexual activity on the part of a male.
http://purl.obolibrary.org/obo/HP_0040307	Male sexual dysfunction	http://purl.obolibrary.org/obo/HP_0012874	Abnormal male reproductive system physiology		A problem occurring during any phase of the male sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity
http://purl.obolibrary.org/obo/HP_0040308	Male anorgasmia	http://purl.obolibrary.org/obo/HP_0046502	Anorgasmia		Inability of a male to reach orgasm.
http://purl.obolibrary.org/obo/HP_0040310	Sterile arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		An inflammatory arthritis characterized by purulent synovial fluid with neutrophil accumulation, but with negative cultures.
http://purl.obolibrary.org/obo/HP_0040311	Symmetric polyarthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		Polyarthritis refers to a joint disease that involves at least five joints. One or more signs of inflammation, including pain, movement restriction, swelling, warmth, and redness, are seen in the joints involved. Polyarthritis is defined as symmetric if at least half of the joints involved are affected in a symmetric (i.e., both right and the left) fashion.
http://purl.obolibrary.org/obo/HP_0040313	Oligoarthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		A type of arthritis that affects up to four joints in the first six months of disease.
http://purl.obolibrary.org/obo/HP_0040314	Blind vagina	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		The vagina ends in a blind pouch or sac rather than being connected to the internal genitalia.
http://purl.obolibrary.org/obo/HP_0040315	Tongue edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		An abnormal accumulation of fluid and swelling in the tongue.
http://purl.obolibrary.org/obo/HP_0040317	Blue urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal blue color of the urine.
http://purl.obolibrary.org/obo/HP_0040318	Red urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal red color of the urine.
http://purl.obolibrary.org/obo/HP_0040319	Dark urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal dark color of the urine.
http://purl.obolibrary.org/obo/HP_0040320	Red-brown urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal red-brown color of the urine.
http://purl.obolibrary.org/obo/HP_0040321	Dark yellow urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal dark-yellow color of the urine.
http://purl.obolibrary.org/obo/HP_0040322	Purple urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal purple color of the urine.
http://purl.obolibrary.org/obo/HP_0040323	Eyelid erythema	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Redness of the skin of the eyelids, caused by hyperemia of the capillaries in the lower layers of the skin.
http://purl.obolibrary.org/obo/HP_0040324	Heliotrope rash	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		In a heliotrope rash, the color of the skin turns to violet, which is the color of the heliotrope flower.
http://purl.obolibrary.org/obo/HP_0040325	Bull's eye rash	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		A cutaneous eruption that consists of multiple (at least two) concentric erythematous rings.
http://purl.obolibrary.org/obo/HP_0040326	Hypoplasia of the olfactory bulb	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		Underdevelopment of the olfactory bulb.
http://purl.obolibrary.org/obo/HP_0040327	Abnormal morphology of the olfactory bulb	http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology		An abnormal morphology of the olfactory bulb (bulbus olfactorius), which is involved in olfaction, i.e. the sense of smell.
http://purl.obolibrary.org/obo/HP_0045086	Knee joint hypermobility	http://purl.obolibrary.org/obo/HP_0010500	Hyperextensibility of the knee		The ability of the knee to move past its normal range of motion, (knee hyperextension is greater than 10 degrees).
http://purl.obolibrary.org/obo/HP_0410017	Otitis externa	http://purl.obolibrary.org/obo/HP_0000372	Abnormal auditory canal morphology		Inflammation or infection of the external auditory canal (EAC), the auricle, or both.
http://purl.obolibrary.org/obo/HP_0410018	Recurrent ear infections	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		Increased susceptibility to ear infections as manifested by recurrent episodes of ear infections.
http://purl.obolibrary.org/obo/HP_0410019	Epigastric pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain that is localized to the region of the upper abdomen immediately below the ribs.
http://purl.obolibrary.org/obo/HP_0410023	Abnormal distribution of cell junction proteins in buccal mucosal cells	http://purl.obolibrary.org/obo/HP_3000019	Abnormal buccal mucosa morphology		An anomalous amount or location of cell junction proteins such as plakoglobin or Cx43.
http://purl.obolibrary.org/obo/GO_0099143	presynaptic actin cytoskeleton	http://purl.obolibrary.org/obo/GO_0015629	actin cytoskeleton		The actin cytoskeleton that is part of a presynapse.
http://purl.obolibrary.org/obo/GO_0120054	intestinal motility	http://purl.obolibrary.org/obo/GO_0022600	digestive system process		Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth).
http://purl.obolibrary.org/obo/UBERON_0036244	secretion of serous membrane	http://purl.obolibrary.org/obo/UBERON_0007779	transudate		A transudate found in the serous sac.
http://purl.obolibrary.org/obo/CHEBI_138103	inorganic acid	http://purl.obolibrary.org/obo/CHEBI_39141	Bronsted acid		A Brønsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.
http://purl.obolibrary.org/obo/HP_0020045	Esodeviation	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		A manifest or latent ocular deviation in which one or both eyes tends to deviate nasally.
http://purl.obolibrary.org/obo/HP_0020049	Exodeviation	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		A manifest or latent ocular deviation in which one or both eyes tends to deviate temporally.
http://purl.obolibrary.org/obo/HP_0031654	Abnormal pulmonary valve physiology	http://purl.obolibrary.org/obo/HP_0031653	Abnormal heart valve physiology		Any functional anomaly of the pumonary valve.
http://purl.obolibrary.org/obo/HP_0031678	Atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis		A lesion associated with atherosclerosis, a multifactorial and multipart progressive disease manifested by the focal development within the arterial wall of lesions, that ranges from the development of a fatty streak, plaque progression, and plaque disruption. Atherosclerotic lesions demonstrate consistent morphological characteristics, which indicate that each type may stabilize temporarily or permanently and that progression to the next type may require an additional stimulus.
http://purl.obolibrary.org/obo/HP_0031703	Abnormal ear morphology	http://purl.obolibrary.org/obo/HP_0000598	Abnormality of the ear		Any structural anomaly of the ear.
http://purl.obolibrary.org/obo/HP_0031704	Abnormal ear physiology	http://purl.obolibrary.org/obo/HP_0000598	Abnormality of the ear		Any functional anomaly of the ear.
http://purl.obolibrary.org/obo/HP_0031705	Compensatory head posture	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		A compensatory head posture occurs when the head is deviated out of the normal primary straight head position in order to compensate for an ocular problem.
http://purl.obolibrary.org/obo/UBERON_0036289	anterior wall of right ventricle	http://purl.obolibrary.org/obo/UBERON_0036286	wall of right ventricle		Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle.
http://purl.obolibrary.org/obo/PR_000049995	active alpha-amylase isozyme	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that has alpha-amylase activity.
http://purl.obolibrary.org/obo/PR_000049996	active alpha-amylase isozyme (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An active alpha-amylase isozyme that is encoded in the genome of human.
http://purl.obolibrary.org/obo/GO_0120178	steroid hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0006694	steroid biosynthetic process		The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
http://purl.obolibrary.org/obo/GO_0062125	regulation of mitochondrial gene expression	http://purl.obolibrary.org/obo/GO_0010468	regulation of gene expression		Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
http://purl.obolibrary.org/obo/PATO_0040030	decreased width and length	http://purl.obolibrary.org/obo/PATO_0000599	decreased width		A width and length quality which is relatively small, where both width and length are decreased.
http://purl.obolibrary.org/obo/CHEBI_151472	N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose	http://purl.obolibrary.org/obo/CHEBI_59266	amino trisaccharide		An amino trisaccharide that comprises of a linear sequence of α-<em>N</em>-acetylneuraminyl, β-<small>D</small>-galactosyl and <small>D</small>-glucose residues linked (2→3) and (1→4). It is found in human milk.
http://purl.obolibrary.org/obo/CL_0019031	intestine goblet cell	http://purl.obolibrary.org/obo/CL_0002563	intestinal epithelial cell		Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.
http://purl.obolibrary.org/obo/CL_0009097	embryonic skeletal muscle fiber	http://purl.obolibrary.org/obo/CL_0008002	skeletal muscle fiber		A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development.
http://purl.obolibrary.org/obo/UBERON_8480000	iliac vein smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004696	venous system smooth muscle		A portion of smooth muscle tissue that is part of an iliac vein.
http://purl.obolibrary.org/obo/UBERON_8480001	capillary of brain	http://purl.obolibrary.org/obo/UBERON_0003499	brain blood vessel		A capillary that is part of the brain.
http://purl.obolibrary.org/obo/UBERON_8480002	thoracic aorta smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004178	aorta smooth muscle tissue		A portion of smooth muscle tissue that is part of the thoracic aorta.
http://purl.obolibrary.org/obo/UBERON_8480003	iliac artery smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0002111	artery smooth muscle tissue		A portion of smooth muscle tissue that is part of an iliac artery.
http://purl.obolibrary.org/obo/UBERON_8480004	iliac vein endothelium	http://purl.obolibrary.org/obo/UBERON_0001919	endothelium of vein		An endothelium that is part of an iliac vein.
http://purl.obolibrary.org/obo/UBERON_8480005	placental artery endothelium	http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue		An endothelium that is part of the placental artery.
http://purl.obolibrary.org/obo/UBERON_8480006	mesenteric lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		Lymphatic vessel that is part of the mesentery.
http://purl.obolibrary.org/obo/UBERON_8480007	placental artery	http://purl.obolibrary.org/obo/UBERON_0022358	placenta blood vessel		An artery that is part of the placenta.
http://purl.obolibrary.org/obo/UBERON_8480008	placental vein	http://purl.obolibrary.org/obo/UBERON_0022358	placenta blood vessel		A vein that is part of the placenta.
http://purl.obolibrary.org/obo/HP_0034442	Abnormal circulating erythropoietin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production.
http://purl.obolibrary.org/obo/HP_0034444	Abnormal gamma-glutamyltransferase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Any deviation from the normal level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.
http://purl.obolibrary.org/obo/HP_0034496	Abnormal brain glutamine level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		A deviation from normal in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HsapDv_0000226	prime adult stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		A life cycle stage that starts at sexual maturity of the human adult, and ends before senescence.
http://purl.obolibrary.org/obo/HsapDv_0000227	late adult stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Late adult stage that refers to an individu who is over 60 and starts to have some age-related impairments.
http://purl.obolibrary.org/obo/HsapDv_0000258	adult stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Human developmental stage that refers to a sexually mature human.
http://purl.obolibrary.org/obo/HsapDv_0000261	infant stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Immature stage that refers to an infant who is over 28 days and is under 12 months old.
http://purl.obolibrary.org/obo/HsapDv_0000262	newborn stage (0-28 days)	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Immature stage that refers to a human newborn within the first 28 days of life.
http://purl.obolibrary.org/obo/HsapDv_0000264	pediatric stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Human developmental stage that covers the period from newborn stage and until 14 years old.
http://purl.obolibrary.org/obo/HsapDv_0000265	child stage (1-4 yo)	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Human stage that refers to a child who is over 12 months and under 5 years old.
http://purl.obolibrary.org/obo/HsapDv_0000267	middle aged stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Late adulthood that refers to an adult who is over 40 and under 60 years old.
http://purl.obolibrary.org/obo/PR_000064867	protein-containing molecular entity	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		A molecular entity that minimally consists of a protein.
http://purl.obolibrary.org/obo/HP_6000449	Occupational exposure to raw nonsynthetic textiles	http://purl.obolibrary.org/obo/HP_0035010	Occupational exposure history		A history of exposure by inhalation of airborne particles generated during the processing of raw, nonsynthetic textiles, particularly cotton. Classically, exposure to cotton dust during the spinning and manufacturing process causes byssinosis. However, exposure to jute, flax, and hemp fibers has also been implicated in its development.
http://purl.obolibrary.org/obo/HP_6000450	Rokitansky-Aschoff gallbladder sinuses	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Localized or diffuse epithelial proliferation with hypertrophy of the muscularis layer and invagination of the mucosa through the muscularis, forming intramural diverticula (i.e., small, bulging pouches in the wall of the gallbladder).
http://purl.obolibrary.org/obo/HP_6000451	Porcelain gallbladder	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Porcelain gallbladder refers to the condition in which the inner gallbladder wall is encrusted with calcium. The wall becomes brittle, hard, and often takes on a bluish hue. It is usually found incidentally on plain abdominal x-rays or other imaging because most patients are asymptomatic.
http://purl.obolibrary.org/obo/HP_6000452	Gallbladder adhesions	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Strands of scar tissue bands of scar tissue that form an abnormal connection between the gallbladder and another abdominal structure. Adhesions can form followiing gallbladder inflammation (cholecystitis).
http://purl.obolibrary.org/obo/HP_6000453	Bilioduodenal fistula	http://purl.obolibrary.org/obo/HP_6001043	Cholecyst-enteric fistula		An abnormal connection between the gallbladder and the duodenum.
http://purl.obolibrary.org/obo/HP_6000454	Pneumobilia	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Accumulation of gas in the biliary tree.
http://purl.obolibrary.org/obo/HP_6000455	Ectopic gallstone	http://purl.obolibrary.org/obo/HP_0001081	Cholelithiasis		A gallstone located outside of the gallbladder.
http://purl.obolibrary.org/obo/HP_6000456	Sleep drunkeness	http://purl.obolibrary.org/obo/HP_0025184	Arousal parasomnia		Sleep drunkenness refers to the prolonged and pronounced difficulty with awakening from nocturnal sleep and daytime naps. This symptom should be distinguished from the milder and physiologic state of sleep inertia seen even in healthy controls.
http://purl.obolibrary.org/obo/HP_6000457	Mallory bodies	http://purl.obolibrary.org/obo/HP_0034713	Abnormal hepatocyte morphology		Cytoplasmic hyaline inclusions of hepatocytes that are predominantly filamentous ranging from a diameter of 3 to 24 nm vs. 10 nm of classical IF. Mallory-Denk bodies can be classified as type I (parallels filaments), II (randomly orient filaments), or III (granular and amorphous). Type II occurs in the periphery while type III occurs around the center. MDB occur in ballooned hepatocytes.
http://purl.obolibrary.org/obo/HP_6000458	Sulfur-containing abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		An abscess containing tiny yellow clumps (sulfur granules), formed by infection with Actinomyces and generally associated with a granulomatous and suppurative infection.
http://purl.obolibrary.org/obo/HP_6000459	Retracted tympanic membrane	http://purl.obolibrary.org/obo/HP_0040090	Abnormal tympanic membrane morphology		A condition in which part of the tympanic membrane is pull backed into the middle ear cavity (also called retraction pocket).
http://purl.obolibrary.org/obo/HP_6000460	Ectopic testis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Localization of the testis in an anatomic location other than the scrotum.
http://purl.obolibrary.org/obo/HP_6000461	Cerebral subcortical cyst	http://purl.obolibrary.org/obo/HP_0010993	Abnormal cerebral subcortex morphology		A fluid-filled sac (cyst) in the region below the cortex of the cerebrum. In magnetic resonance imaging, the fluid within the cyst has the same appearance as cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_6000462	Anti-ADAMTS13 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against A Disintegrin and Metalloprotease with ThromboSpondin type 1 repeats, member 13 (ADAMTS13).
http://purl.obolibrary.org/obo/HP_6000463	Habitual mouth breathing	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		A tendency to breathe through the mouth. Defined as over 25-30 percent of the air passing through the mouth instead of the nose, mouth breathing often occurs due to upper airway obstruction which reduces the nasal airflow and forces the air to enter completely or partially through oral cavity.
http://purl.obolibrary.org/obo/HP_6000464	Squared off shoulders	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		An appearance of the shoulders whereby the neck-trapezius angle (angle between the neck and the shoulder) and the angle formed by the shoulder and the arms hanging at the side of the body are both close to 90 degrees. This gives the should the appearance of the corner of a square.
http://purl.obolibrary.org/obo/HP_6000465	Elevated urine mesaconic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The amount of mesaconic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000466	Elevated urine 3-methyladipic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The amount of 3-methyladipic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000467	Elevated urine D-lactate level	http://purl.obolibrary.org/obo/HP_0012072	Aciduria		The amount of D-lactate in the urine, normalized for urine concentration, is above the upper limit of normal. L-lactate is a familiar molecule to the human body and is also produced in large amounts in human tissues, depending on metabolic conditions. In contrast, D-lactate is produced only in minute quantities in human tissues, and is therefore not detectable in the bloodstream under normal physiological conditions.
http://purl.obolibrary.org/obo/HP_6000468	Elevated CSF alpha-ketoglutarate concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		The concentration of alpha-ketoglutarate in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000469	Elevated urine 2,3-dihydroxy-2-methylbutanoic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		The amount of 2,3-dihydroxy-2-methylbutanoic acidin the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000470	Fetal oral mass	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		A swelling or enlargement localized to the oral cavity of a fetus. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined. This finding is generally first observed by prenatal sonography or magnetic resonance imaging.
http://purl.obolibrary.org/obo/HP_6000471	Dilated ejaculatory duct	http://purl.obolibrary.org/obo/HP_0000022	Abnormal male internal genitalia morphology		Increase in diameter of the ejeculatory duct. The ejaculatory duct delivers sperm into the urethra, adding secretions from the prostate and is formed by the union of the vas deferens with the duct of the seminal vesicle.
http://purl.obolibrary.org/obo/HP_6000472	Decreased Wiskott-Aldrich syndrome protein concentration in hematopoietic cells	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		The concentration of Wiskott-Aldrich syndrome protein in hematopoietic cells is below the lower limit of normal. This feature is measured by flow cytometry or Western blotting.
http://purl.obolibrary.org/obo/HP_6000473	Decreased FOXP3-expressing T cell count	http://purl.obolibrary.org/obo/HP_0002843	Abnormal T cell morphology		The number of T cells in peripheral blood that express FOXP3-expressing is below the lower limit of normal. This finding is determined by flow cytometry.
http://purl.obolibrary.org/obo/HP_6000475	Anti-beta fodrin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a component of beta-fodrin.
http://purl.obolibrary.org/obo/HP_6000476	Elevated circulating tetradecenoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033465	Elevated circulating tetradecanoylcarnitine concentration		The concentration of tetradecenoylcarnitine (C14:1) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000477	Elevated urine 2-trans,4-cis-decadienoylcarnitine level	http://purl.obolibrary.org/obo/HP_0500170	Abnormal concentration of acylcarnitine in the urine		The amount of 2-trans,4-cis-decadienoylcarnitine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000478	Elevated circulating 2-trans,4-cis-decadienoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration		The concentration of 2-trans,4-cis-decadienoylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000479	Elevated urine N-acetyltyrosine level	http://purl.obolibrary.org/obo/HP_0033090	Increased aromatic amino acid level in urine		The amount of N-acetyltyrosine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000480	Elevated urine manganese level	http://purl.obolibrary.org/obo/HP_0025640	Abnormal urinary mineral level		The amount of manganese in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000481	Reduced urinary manganese level	http://purl.obolibrary.org/obo/HP_0025640	Abnormal urinary mineral level		The amount of manganese in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000482	Decreased circulating catecholamine concentration	http://purl.obolibrary.org/obo/HP_0012099	Abnormal circulating catecholamine concentration		Concentration of a catecholamine in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000483	Empty sella turcica	http://purl.obolibrary.org/obo/HP_0002679	Abnormal sella turcica morphology		Empty sella or arachnoidocele has been defined as the herniation of the subarachnoid space within the sella turcica, associated with elongated pituitary stalk and flattening of the pituitary gland.
http://purl.obolibrary.org/obo/HP_6000484	Elevated brain guanidinoacetate level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An increase in the level of guanidinoacetate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_6000485	Elevated circulating beta-hCG concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of beta-hCG in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000486	Elevated circulating CXCL10 concentration	http://purl.obolibrary.org/obo/HP_0011115	Abnormal circulating chemokine concentration		The concentration of C-X-C motif chemokine 10 (CXCL10) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000487	Reduced circulating interleukin 12 concentration	http://purl.obolibrary.org/obo/HP_6000442	Abnormal circulating interleukin 12 concentration		The concentration of interleukin 12 (IL-12) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000488	Reduced circulating fibroblast growth factor 23 concentration	http://purl.obolibrary.org/obo/HP_6000489	Abnormal circulating fibroblast growth factor 23 concentration		The concentration of fibroblast growth factor 23 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000489	Abnormal circulating fibroblast growth factor 23 concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		The concentration of fibroblast growth factor 23 in the blood circulation is outside of the limits of normal.
http://purl.obolibrary.org/obo/HP_6000490	Impaired heel-walking ability	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Difficulty or reduced ability to walk on heels. Heel-walking can be tested as a part of the neurological examination. Foot dorsal extension weakness leads to difficulties in walking on heels.
http://purl.obolibrary.org/obo/HP_6000491	Anti-prothrombin antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against prothrombin.
http://purl.obolibrary.org/obo/HP_6000492	Anti-factor V antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against factor V.
http://purl.obolibrary.org/obo/HP_6000493	Anti-factor VII antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against factor VII.
http://purl.obolibrary.org/obo/HP_6000494	Anti-factor VIII antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against factor VIII.
http://purl.obolibrary.org/obo/HP_6000495	Anti-factor IX antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against factor IX.
http://purl.obolibrary.org/obo/HP_6000496	Anti-factor X antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of an antibody in the blood circulation that is directed against factor X.
http://purl.obolibrary.org/obo/HP_6000497	Anti-factor XI antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of an antibody in the blood circulation that is directed against factor XI.
http://purl.obolibrary.org/obo/HP_6000498	Anti-factor XIII antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of an antibody in the blood circulation that is directed against factor XIII.
http://purl.obolibrary.org/obo/HP_6000499	Anti-factor H antibody positivity	http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity		The presence of an antibody in the blood circulation that is directed against factor H.
http://purl.obolibrary.org/obo/HP_6000500	Extremities cold to touch	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Cool or cold arms or legs related to peripheral vasoconstriction, the narrowing of blood vessels resulting from the contraction of muscular walls in large arteries and the small arterioles of skin and most internal organs. Following exposure to low ambient temperatures, vasoconstriction decreases heat dissipation from skin surfaces, thus preventing life-threatening hypothermia.
http://purl.obolibrary.org/obo/HP_6000501	Ruffled acrosome	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		An irregular wavy appearance of sperm acrosomes.
http://purl.obolibrary.org/obo/HP_6000502	Elevated circulating calprotectin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of calprotectin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000503	4-5 toe cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010621	Cutaneous syndactyly of toes		A soft tissue continuity in the anteroposterior axis between the toes 4 and 5.
http://purl.obolibrary.org/obo/HP_6000504	Poly-hill sign	http://purl.obolibrary.org/obo/HP_0001446	Abnormality of the musculature of the upper limbs		A typical physical examination in patients with muscular dystrophies and selective weakness and atrophy of the trapezius muscle and proximal deltoid muscle. The contour of the back shows unique hills and drops.
http://purl.obolibrary.org/obo/HP_6000505	3-5 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010710	3-5 finger syndactyly		A soft tissue continuity in the anteroposterior axis between the third to the fifth fingers that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_6000506	Radioulnar subluxation	http://purl.obolibrary.org/obo/HP_0003059	Abnormality of the radioulnar joints		Partial dislocation of the radioulnar joint.
http://purl.obolibrary.org/obo/HP_6000507	Non-pitting edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Non-pitting edema occurs when excess fluid builds up in the body causing swelling that does not indent when pressure is applied. It usually occurs in the limbs, and often results from underlying medical conditions affecting lymphatic system function.
http://purl.obolibrary.org/obo/HP_6000508	Anti-human ferritin peptide antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the human ferritin peptide.
http://purl.obolibrary.org/obo/HP_6000509	Elevated CSF L-2-hydroxyglutaric acid concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		The concentration of L-2-hydroxyglutaric acid in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000510	Elevated erythrocyte inosine triphosphate concentration	http://purl.obolibrary.org/obo/HP_0034737	Abnormal erythrocyte metabolite concentration		Concentration of inosine triphosphate in red blood cells is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000511	Reduced erythrocyte inosine triphosphatase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of inosine triphosphate pyrophosphohydrolase (EC 3.6.1.19) in red blood cells below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000512	Reduced circulating alpha-1,3-fucosyltransferase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Concentration or activity of alpha-1,3-fucosyltransferase is below the lower limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_6000513	Diminished neutrophil myeloperoxidase activity	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		Activity of the enzyme myeloperoxidase (EC 1.11.1.7) in neutrophils below the lower limit of normal. This feature can be measured by peroxidase cytochemistry or biochemical assays. Myeloperoxidase is a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear leukocytes and monocytes.
http://purl.obolibrary.org/obo/HP_6000514	Reduced erythrocyte uroporphyrinogen III cosynthase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of in the level of uroporphyrinogen III (EC 4.2.1.75) in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000515	Elevated 18-hydroxycorticosterone to aldosterone ratio	http://purl.obolibrary.org/obo/HP_0012112	Abnormal circulating corticosterone level		The relative concentration in the blood circulation of 18-hydroxycorticosterone compared to that of aldosterone is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000516	Elevated circulating 21-deoxycortisol concentration	http://purl.obolibrary.org/obo/HP_0003118	Increased circulating cortisol level		The concentration of 21-deoxycortisol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000517	Elevated monolysocardiolipin/cardiolipin ratio	http://purl.obolibrary.org/obo/HP_0040176	Abnormal circulating phospholipid concentration		The concentration of monolysocardiolipin related to that of cardiolipin is above the upper limit of normal. This is a functional assay that can be performed from a blood spot to diagnose Barth syndrome (OMIM:302060).
http://purl.obolibrary.org/obo/HP_6000518	Low maternal vitamin B12 concentration	http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening		The concentration of vitamin B12 in the mother's blood during pregnancy is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000519	Elevated circulating inhibin A concentration	http://purl.obolibrary.org/obo/HP_0031099	Abnormal circulating inhibin level		The concentration of inibin A in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000520	Increased circulating inhibin B concentration	http://purl.obolibrary.org/obo/HP_0430147	Abnormal circulating inhibin B concentration		The concentration of inhibin B in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000521	Elevated circulating lipoprotein(a) concentration	http://purl.obolibrary.org/obo/HP_0430148	Abnormal circulating lipoprotein(a) concentration		The concentration of lipoprotein(a) in the blood circulation is above the upper limit of normal. Lipoprotein(a), also known as apolipoprotein(A), is encoded by LPA (HGNC:6667).
http://purl.obolibrary.org/obo/HP_6000522	Reduced circulating lipoprotein(a) concentration	http://purl.obolibrary.org/obo/HP_0430148	Abnormal circulating lipoprotein(a) concentration		The concentration of lipoprotein(a) in the blood circulation is below the lower limit of normal. Lipoprotein(a), also known as apolipoprotein(A), is encoded by LPA (HGNC:6667).
http://purl.obolibrary.org/obo/HP_6000524	Abnormal urinary bile acid level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		The amount of bile acids in the urine, normalized for urine concentration, is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_6000525	Reduced erythrocyte glutathione reductase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity of glutathione reductase (EC 1.6.4.2) in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000526	Failure to elevate lactate upon ischemic exercise test	http://purl.obolibrary.org/obo/HP_0011014	Abnormal glucose homeostasis		Failure to elevate lactate in blood washed out from ischemically exercised muscles as assayed by the forearm ischemic exercise test.
http://purl.obolibrary.org/obo/HP_6000527	Elevated circulating cholestanol concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		The concentration of cholestanol in the blood circulation is above the upper limit of normal. Cholestanol is the 5-alpha-dihydro derivative of cholesterol.
http://purl.obolibrary.org/obo/HP_6000528	Livestock exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A medical history of having been exposed to livestock (animals such as cattle and sheep which are kept on a farm ).
http://purl.obolibrary.org/obo/HP_6000529	Synchronous skin lesions	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality of the skin in which multiple lesions occur at the same time.
http://purl.obolibrary.org/obo/HP_6000530	Serpentine skin location	http://purl.obolibrary.org/obo/HP_0012830	Position		Refers to a skin lseion that has a snake-like (serpentine) shape.
http://purl.obolibrary.org/obo/HP_6000532	Elevated urinary histamine level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		The amount of histamine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000533	Elevated urinary N-methylhistamine level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		The amount of N-methylhistamine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000534	Elevated urinary ureidopropionic acid level	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		The amount of ureidopropionic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000535	Elevated urinary porphyrin level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		The amount of a porphyrin compound in the urine, normalized for urine concentration, is above the upper limit of normal. Porphrins are natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to form a macrocyclic structure. Porpyrins giove rise to heme and combalamine.
http://purl.obolibrary.org/obo/HP_6000536	Elevated urinary coproporphyrin level	http://purl.obolibrary.org/obo/HP_6000535	Elevated urinary porphyrin level		The amount of a coproporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000537	Eccrine sweat gland predominance	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality of the skin that is located in or surrounding eccrine sweat glands.
http://purl.obolibrary.org/obo/HP_6000538	Poorly demarcated skin lesion	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality of the skin whose boundary to the surrounding normal skin is not clearly defined.
http://purl.obolibrary.org/obo/HP_6000539	History of recent cat bite	http://purl.obolibrary.org/obo/HP_0020138	History of recent animal bite		Medical history of a recent bite or scratch injury due to a cat.
http://purl.obolibrary.org/obo/HP_6000540	History of recent stay in area with inadequate sewage sanitation	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A history of having been in an area with inadequate sewage sanitation in the recent past.
http://purl.obolibrary.org/obo/HP_6000541	Positive cutaneous herpes simplex virus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test		Detection of cutaneous herpes simplex virus nucleic acid in the skin by a method such as polymerase chain reaction. The sample is usually obtained by cutaneous swabs from skin lesions.
http://purl.obolibrary.org/obo/HP_6000542	Positive CSF mycobacterium tuberculosis nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of Mycobacterium tuberculosis nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000544	Positive mycobacterium CSF microscopy	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		The demonstration of mycobacterium by microscopy of the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_6000545	Positive treponema pallidum PCR test in the blood circulation	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of treponema pallidum in the blood circulation by a method such a polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000546	Positive human Immunodeficiency virus nucleic acid test in the blood circulation	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of human immunodeficiency vrus (HIV) in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000547	Positive CSF enterovirus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of enteroviral nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000548	Positive CSF Borrelia burgdorferi nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of Borrelia burgdorferi nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000549	Positive CSF arbovirus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of arbovus nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR..
http://purl.obolibrary.org/obo/HP_6000550	Positive Bartonella henselae nucleic acid test in the blood circulation	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of Bartonella henselae in the blood circulation by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000551	Positive Dengue virus PCR test in the blood circulation	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of the Dengue virus in the blood circulation by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000552	Positive CSF JC-virus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of JC-virus nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000553	Bloodstream Malaria parasite	http://purl.obolibrary.org/obo/HP_0034523	Blood parasite		Presence of malaria parasites in the peripheral blood.
http://purl.obolibrary.org/obo/HP_6000554	Positive bloodstream plasmodium falciparum nucleic acid pathogen test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of Plasmodium falciparum (a type of Malaria parasite) in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000555	Decreased erythrocyte fructose-1,6-bisphosphate aldolase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) in red blood cells below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000556	Reduced circulating dopamine beta-hydroxylase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Concentration of Dopamine beta-hydroxylase (DBH; EC 1.14.17.1) in the blood circulation below the lower limit of normal. DBH catalyzes the oxidative hydroxylation of dopamine to norepinephrine.
http://purl.obolibrary.org/obo/HP_6000557	Reduced erythrocyte bisphosphoglycerate mutase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of bisphosphoglycerate mutase (BPGM; EC 5.4.2.4;) in red blood cells below the lower limit of normal. BPGM is a multifunctional enzyme specifically found in red blood cells that synthesizes 2,3-diphosphoglycerate through its synthase activity and degrades it through its phosphatase activity.
http://purl.obolibrary.org/obo/HP_6000558	Reduced erythrocyte adenylate kinase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of in the level of adenylate kinase (EC 2.7.4.3) in erythrocytes below the lower limit of normal. Adenylate kinase is a ubiquitous monomeric enzyme that catalyzes the reversible conversion of MgATP plus AMP to MgADP plus ADP and contributes to homeostasis of the adenine nucleotide composition in the cell.
http://purl.obolibrary.org/obo/HP_6000559	Reduced erythrocyte hexokinase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of hexokinase (EC 2.7.1.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle.
http://purl.obolibrary.org/obo/HP_6000560	Decreased circulating carboxypeptidase N activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme Carboxypeptidase N (arginine carboxypeptidase, EC 3.4.17.3) in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000561	Elevated red cell pyruvate kinase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of pyruvate kinase (EC 2.7.1.40) in erythrocytes above the upper limit of normal. Pyruvate kinase (EC 2.7.1.40) is a glycolytic enzyme that catalyzes the transphosphorylation from phosphoenolpyruvate (PEP) to ADP, yielding pyruvate and ATP.
http://purl.obolibrary.org/obo/HP_6000562	Reduced circulating adenosine deaminase-2 activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Concentration of adenosine deaminase 2 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000563	Reduced sepiapterin reductase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase; EC 1.1.1.153) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000564	Elevated circulating vasoactive intestinal peptide concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		The concentration of vasoactive intestinal peptide (VIP) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000565	Elevated circulating cholesterol sulfate concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		The concentration of cholesterol sulfate in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000566	Elevated circulating lipoprotein-X concentration	http://purl.obolibrary.org/obo/HP_0010980	Hyperlipoproteinemia		The concentration of lipoprotein-X in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000567	Elevated circulating oxalate concentration	http://purl.obolibrary.org/obo/HP_0040145	Dicarboxylic acidemia		The concentration of oxalate in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000568	Elevated blood ethylene glycol concentration	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		The concentration of ethylene glycol in the blood is above the upper limit of a guidance value for total concentrations that implies possible injurious effects.
http://purl.obolibrary.org/obo/HP_6000569	Midline notching of lower lip	http://purl.obolibrary.org/obo/HP_0000178	Abnormal lower lip morphology		Exaggerated indentation at the very middle (midline) of the lower lip.
http://purl.obolibrary.org/obo/HP_6000570	Reduced tissue thymidine phosphorylase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of thymidine phosphorylase (EC 2.4.2.4) in the tissues below the lower limit of normal. The activity can be measured in multiple tissues including leukocytes.
http://purl.obolibrary.org/obo/HP_6000571	Reduced tissue tripeptidyl peptidase 1 activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of tripeptidyl peptidase 1 (TPP1;EC 3.4.14.9) in the tissues below the lower limit of normal. TTP1 activity can be measured in tissues including fibroblasts and leukocytes muscle.
http://purl.obolibrary.org/obo/HP_6000572	Reduced tissue arginine:glycine amidinotransferase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of L-arginine:glycine amidinotransferase (GATM; EC 2.1.4.1) in the tissues below the lower limit of normal. GATM activity can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000573	Reduced tissue aspartylglucosaminidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of aspartylglucosaminidase (AGA; EC 3.5.1.26) in the tissues below the lower limit of normal. AGA activity can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000574	Reduced tissue carnitine-acylcarnitine translocase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of carnitine-acylcarnitine translocase (CACT) in tissues below the lower limit of normal. CACT activity can be measured in multiple tissues.
http://purl.obolibrary.org/obo/HP_6000575	Reduced circulating 6-pyruvoyltetrahydropterin synthase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of 6-pyruvoyltetrahydropterin synthase in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000576	Reduced tissue mannosyl-oligosaccharide glucosidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of mannosyl-oligosaccharide glucosidase (MOGS) in tissues below the lower limit of normal. MOGS activity can be measured in multiple tissues including liver and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000577	Reduced tissue 3-methylglutaconyl-CoA hydratase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of the mitochondrial enzyme 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18) in tissues below the lower limit of normal. The activity can be measured in multiple tissues including culutured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000578	Reduced tissue gamma-glutamyltransferase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of gamma-glutamyltransferase in the tissues below the lower limit of normal. The activity can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000579	Positive oropharangeal infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Any kind of test for an infectious agent in the oropharynx positive. The oropharynx is defined as the middle part of the throat and includes the soft palate, the side and back walls of the throat, the tonsils, and the posterior one-third of the tongue.
http://purl.obolibrary.org/obo/HP_6000580	Positive oropharynx poliovirus nucleic acid test	http://purl.obolibrary.org/obo/HP_6000579	Positive oropharangeal infectious agent test		Detection of poliovirus nucleic acid in the oropharynx by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000581	Positive synonvial fluid infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Any kind of test for an infectious agent in the synovial fluid (i.e., in a joint) positive.
http://purl.obolibrary.org/obo/HP_6000582	Positive synonvial fluid culture	http://purl.obolibrary.org/obo/HP_6000581	Positive synonvial fluid infectious agent test		Growth of an infectious agent in a culture derived from synovial fluid.
http://purl.obolibrary.org/obo/HP_6000583	Positive synovial fluid gram stain	http://purl.obolibrary.org/obo/HP_6000581	Positive synonvial fluid infectious agent test		Demonstration of the presence of bacteria by gram staining of joint (synovial) fluid. The sample is generally obtained by arthrocentesis.
http://purl.obolibrary.org/obo/HP_6000584	Anti Parvovirus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of parvovirus.
http://purl.obolibrary.org/obo/HP_6000585	Brain parenchymal tuberculoma	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		Tuberculoma results from hematogenous spread of Mycobacterium tuberculosis (M. tb) from an extracranial source. Diagnosis is based on computed tomography (CT) scan and magnetic resonance imaging (MRI) studies with a similar ring-enhancing lesion.
http://purl.obolibrary.org/obo/HP_6000586	Muscle arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in muscle tissue.
http://purl.obolibrary.org/obo/HP_6000587	Bone arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in a bone.
http://purl.obolibrary.org/obo/HP_6000588	Periosteal elevation	http://purl.obolibrary.org/obo/HP_0030313	Abnormal periosteum morphology		Lifting or separation of the periosteum from the outer surface of a bone. Periosteal elevation is usually seen in benign process, frequently in cranioencephalic traumas. There is an elevation of the periosteum after blood, like in cephalohematomas.
http://purl.obolibrary.org/obo/HP_6000589	Esophageal dilation	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Widening (relatively uniform increase in diameter) of a segment of the esophagus.
http://purl.obolibrary.org/obo/HP_6000590	Spinal lipoma	http://purl.obolibrary.org/obo/HP_0012032	Lipoma		A lipoma that is localized to the spine.
http://purl.obolibrary.org/obo/HP_6000591	Loose body in joint	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		Small fragments of articular cartilage that break off in a joint as a result of a injury, degeneration, or other processes.
http://purl.obolibrary.org/obo/HP_6000592	Paraspinal arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in adjacent to the spine, i.e., in a location that is normally occupied by muscles, ligaments, nerves, and other tissues that run alongside the spinal column.
http://purl.obolibrary.org/obo/HP_6000593	Supernumerary tarsal bone	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		The presence of an additional tarsal bone that is not one of the canonical tarsal bones (cuboid, medial, intermediate, and lateral cuneiform, navicular, talus, calcaneus).
http://purl.obolibrary.org/obo/HP_6000594	Maxillary cyst	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		A closed sac that has developed in the upper jaw bone (maxilla) and contains fluid or semi-solid material. Cystic lesions of the maxilla are benign entities with both odontogenic and non-odontogenic origins.
http://purl.obolibrary.org/obo/HP_6000595	Mandibular cyst	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		A closed sac that has developed in the lower jaw bone (mandibula) and contains fluid or semi-solid material.
http://purl.obolibrary.org/obo/HP_6000596	Sixth cranial nerve hypoplasia	http://purl.obolibrary.org/obo/HP_0011348	Abnormal sixth cranial nerve morphology		Underdevelopment of the six cranial nerve (abducens nerve).
http://purl.obolibrary.org/obo/HP_6000597	Third cranial nerve hypoplasia	http://purl.obolibrary.org/obo/HP_0025735	Abnormal third cranial nerve morphology		Underdevelopment of the third cranial nerve (oculomotor nerve).
http://purl.obolibrary.org/obo/HP_6000598	Elevated urinary succinylacetone level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Presence in the urine of succinylacetone, which is one of the toic block metabolites formed in tyrosinaemia type 1 because of a defect in the final enzyme of the pathway of the degradation of tyrosine, namely fumarylacetoacetase (FAH, EC 3.7.1.2).
http://purl.obolibrary.org/obo/HP_6000599	Elevated urinary 2-oxoisocaproic level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		The amount of 2-oxoisocaproic in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000600	Elevated urinary 2-oxovaleric acid level	http://purl.obolibrary.org/obo/HP_0033456	Elevated urine keto acid level		The amount of 2-oxovaleric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000601	Elevated urinary 2-hydroxyisocaproic acid level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		The amount of 2-hydroxyisocaproic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000602	Elevated urinary isovalerylglycine level	http://purl.obolibrary.org/obo/HP_0012073	Abnormal urinary acylglycine profile		The amount of isovalerylglycine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000603	Elevated urinary 2-methyl-3-hydroxybutyric acid level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		The amount of 2-methyl-3-hydroxybutyric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000604	Elevated urinary 3-hydroxypentanoic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		The amount of 3-hydroxypentanoic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000605	Elevated urinary 7-hydroxyoctanoic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		The amount of 7-hydroxyoctanoic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000606	Elevated urinary D-glyceric acid level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		The amount of D-glyceric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000607	Elevated urinary 3-hydroxyisobutyric acid level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		The amount of 3-hydroxyisobutyric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000608	Elevated urinary 3,4-Dihydroxybutyric acid level	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The amount of 3,4-Dihydroxybutyric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000609	Elevated urinary 3-hydroxyadipic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The amount of 3-hydroxyadipic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000610	Elevated erythrocyte galactose-1-phosphate concentration	http://purl.obolibrary.org/obo/HP_0034737	Abnormal erythrocyte metabolite concentration		Concentration of galactose-1-phosphate in red blood cells (erythrocytes) above the upper level of normal.
http://purl.obolibrary.org/obo/HP_6000611	Elevated circulating chitotriosidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Increased activity or concentration of the enzyme chitotriosidase. Serum chitotriosidase is a biomarker that has shown high specificity and sensitivity in patients with sarcoidosis.
http://purl.obolibrary.org/obo/HP_6000612	Squamosal suture synostosis	http://purl.obolibrary.org/obo/HP_0001363	Craniosynostosis		Premature closure of the squamosal suture, which is one of the lateral minor skull sutures, separating the parietal and squamous temporal bones.
http://purl.obolibrary.org/obo/HP_6000613	Enlarged fetal lungs	http://purl.obolibrary.org/obo/HP_0034243	Abnormal fetal pulmonary morphology		The size (volume) of the lungs of a fetus above the upper limit of normal for the gestational age.
http://purl.obolibrary.org/obo/HP_6000614	Orbital inflammation	http://purl.obolibrary.org/obo/HP_0000315	Abnormality of the orbital region		An inflammatory condition localized to the orbit, presenting capillary dilatation, leukocytic infiltration, redness, heat, and pain. CT or MIR Imaging demonstrates enlargement of the muscle belly of one (or more) extraocular muscles typically with the involvement of tendinous insertions. Inflammation can also be observed in surrounding tissues, including the orbital fat, lacrimal gland, and optic nerve sheath.
http://purl.obolibrary.org/obo/HP_6000615	Reduced Inositol polyphosphate 5-phosphatase OCRL-1 activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of inositol polyphosphate 5-phosphatase OCRL-1 as measured in cultured fibroblasts is below the limits of normal. This enzyme has phosphoinositide 5-phosphatase (EC 3.1.3.36) activity.
http://purl.obolibrary.org/obo/HP_6000616	Reduced muscle glycogen debrancher enzyme activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the gycogen debrancher enzyme (GDE) in muscle tissue is below the lower limit of normal. GDE is a large monomeric protein with two catalytic activities: amylo-1,6-glucosidase (EC 3.2.1.33) and 4-alpha-glucanotransferase (EC 2.4.1.25).
http://purl.obolibrary.org/obo/HP_6000617	Reduced tissue UDP-glucuronyl-transferase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of uridine diphosphate glucuronosyltransferase below the lower limit of normal. The activity of this enzyme can be measured in liver and rarely in other tissues.
http://purl.obolibrary.org/obo/HP_6000618	Temporal artery giant cells	http://purl.obolibrary.org/obo/HP_0430104	Abnormal superficial temporal artery morphology		The presence of giant cells in the temporal artery. This is a feature of giant cell arteritis. Giant cells are multinucleated cells formed by fusion of multiple macrophages and are typically located in the intima of the arterial wall. This feature is typically demonstrated by temporal artery biopsy but other arteries may also be affected.
http://purl.obolibrary.org/obo/HP_6000619	Reduced phosphoenolpyruvate carboxykinase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of phosphoenolpyruvate carboxykinase (EC 4.1.1.32) is below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000620	Elevated urinary pyrroline hydroxycarboxylic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of pyrroline hydroxycarboxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000621	Elevated urinary N-tau-ribosylhistidine level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		Presence of N tau-ribosylhistidine (His-R) in the urine. His-R is a histidine derivative found in the urine of histidinemic patients.
http://purl.obolibrary.org/obo/HP_6000622	Elevated urinary ureidoisobutyric acid level	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		The amount of ureidoisobutyric acid in the urine, normalized for urine concentration, is above the upper limit of normal. Ureidoisobutyric acid is increased in the urine of patients with beta-ureidopropionase (EC 3.5.1.6) deficiency.
http://purl.obolibrary.org/obo/HP_6000623	Elevated urinary N-carbamyl-beta-aminoisobutyric acid level	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		The amount of N-carbamyl-beta-aminoisobutyric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000624	Nipple epidermal Paget cells	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		Malignant, intraepithelial adenocarcinoma cells of variable sizes usually large in size, present singly or in the form of small groups within the epidermis of the nipple. Cells may be ovoid, round, or signet-ring forms, usually mucin positive, and the cytoplasm may contain periodic acid-Schiff (PAS)-positive, diastase-resistant granules, indicating the presence of neutral mucopolysaccharides. The cells possess microscopic features of glandular cells with pale to clear vacuolated cytoplasm, and nuclei are usually high-grade with prominent nucleoli.
http://purl.obolibrary.org/obo/HP_6000625	Penile corporal blood gas ischemia	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Partial pressure of oxygen (pO2) in cavernous blood of the penis is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000626	Recent temporal region trauma	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A history of an injury to the temporal region of the skull that occurred recently (several hours, days, or weeks before the current presenting complaint).
http://purl.obolibrary.org/obo/HP_6000627	Rest limb pain	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Rest pain is a continuous unrelenting pain due to ischemia of the lower leg, beginning with or being aggravated by elevation and being relieved by sitting with legs in a dependent position or by standing.
http://purl.obolibrary.org/obo/HP_6000628	Scalloped appearance of liver surface	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		A lesion associated with pseudomyxoma peritonei whosetypical CT appearance is scalloping of the surface of the liver and spleen caused by loculated accumulations of mucin, which distinguishes mucin from fluid ascites. The mucinous material is similar in density to water. There are also islands of higher attenuation due to scattered solid elements and calcification within mucinous material.
http://purl.obolibrary.org/obo/HP_6000629	Nipple thickening	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		Thickening of the skin around the nipple.
http://purl.obolibrary.org/obo/HP_6000630	Hypoechoic breast mass	http://purl.obolibrary.org/obo/HP_0032408	Breast mass		A breast mass visualized by sonography that displays a lower than normal echo signal (and this that appears dark gray in the typical ultrasound image).
http://purl.obolibrary.org/obo/HP_6000631	Unilocular ovarian cyst	http://purl.obolibrary.org/obo/HP_0000138	Ovarian cyst		An ovarian cyst without septa and a solid component.
http://purl.obolibrary.org/obo/HP_6000632	Mesenteric torsion	http://purl.obolibrary.org/obo/HP_0100016	Abnormal mesentery morphology		Mesenteric torsion is a pathological rotation of the intestinal tract around the axis of the mesenteric root, resulting in rapid occlusion of the cranial mesenteric artery.
http://purl.obolibrary.org/obo/HP_6000633	High-pitched bowel sounds	http://purl.obolibrary.org/obo/HP_0030142	Abnormal bowel sounds		Abnormal bowel sounds of an unually high frequency.
http://purl.obolibrary.org/obo/HP_6000634	Exacerbated by opiate medication	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign orr symptom that is worsed by administration of opiate medications.
http://purl.obolibrary.org/obo/HP_6000635	Breast granuloma	http://purl.obolibrary.org/obo/HP_5210340	Non-caseating granulomatosis		Formation of a non-necrotizing granuloma in breat tissue typically in combination with a localized infiltrate of multi-nucleated giant cells, epithelioid histiocytes, lymphocytes, and plasma cells.
http://purl.obolibrary.org/obo/HP_6000636	Exposure to cosmetic fragrances	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of exposure to fragrances found in cosmetic products.
http://purl.obolibrary.org/obo/HP_6000637	Sweating and flushing in the preauricular area in response to mastication	http://purl.obolibrary.org/obo/HP_0031911	Abnormal fifth cranial nerve physiology		Sweating and flushing in the preauricular area in response to mastication or a salivary stimulus. Facial warmth, flushing, and sweating in the territory of the auriculotemporal nerve overlying the parotid gland, which may include the preauricular skin, the temporal skin, the scalp, and the temporomandibular joint region. Symptoms occur during meals, especially with spicy and sour foods. This feature is inferred to be a consequence of injury to the auriculotemporal nerve, a branch if the trigeminal nerve.
http://purl.obolibrary.org/obo/HP_6000638	Reduced hepatic glyoxylate reductase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of glyoxylate reductase/hydroxypyruvate reductase (GRHPR; EC 1.1.1.79) in liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000639	PAS-positive lymphocyte vacuolization	http://purl.obolibrary.org/obo/HP_0001922	Vacuolated lymphocytes		Presence of lymphocytes with positive staining for periodic acid-Schiff (PAS) cytoplasmic vacuoles.
http://purl.obolibrary.org/obo/HP_6000640	Lipid-laden bone-marrow macrophages	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		Bone marrow with increased numbers of macrophages heavily laden with lipids.
http://purl.obolibrary.org/obo/HP_6000641	Bone marrow monocytosis	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		Increased count of monocytes in the bone marrow.
http://purl.obolibrary.org/obo/HP_6000642	Sunflower cataract	http://purl.obolibrary.org/obo/HP_0010923	Anterior subcapsular cataract		Sunflower cataract (SC) is a type of anterior subcapsular cataract almost only seen in Wilson disease, an autosomal-recessive condition with a defect in the metabolism of copper leading to accumulation of copper in the liver and basal ganglia. SC consists of a thin, centralized opacification that is located directly under the anterior capsule and encompasses between one-third and one-half of the anterior lens pole surface area. In all cases, the central opacification is surrounded by additional, secondary opacifications arranged in ray-like structures around it. This pattern is said to resemble a sunflower, with a large central disk surrounded by petals.
http://purl.obolibrary.org/obo/HP_6000643	Anti-lamin A antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against lamin A.
http://purl.obolibrary.org/obo/HP_6000644	Anti-lamin C antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the blood circulation that react against human lamin C.
http://purl.obolibrary.org/obo/HP_6000645	Anti-vinculin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against vinculin.
http://purl.obolibrary.org/obo/HP_6000646	Anti-annexin A5 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against annexin A5.
http://purl.obolibrary.org/obo/HP_6000647	Bulging fontanelle	http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology		An outward curving of a fontanelle, which occurs when fluid builds up in the brain or the brain swells, causing increased pressure inside the skull.
http://purl.obolibrary.org/obo/HP_6000648	3-4 toe cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010621	Cutaneous syndactyly of toes		A soft tissue continuity in the anteroposterior axis between the toes 3 and 4.
http://purl.obolibrary.org/obo/HP_6000649	Triangular nail	http://purl.obolibrary.org/obo/HP_0025755	Abnormal nail shape		Nail so wide as long with a distal part presenting an acute angle.
http://purl.obolibrary.org/obo/HP_6000650	Distal tibiofibular synostosis	http://purl.obolibrary.org/obo/HP_0005929	Synostosis involving the tibia		Fusion of the distal (i.e.., located away from the trunk) part of the tibia and fibula.
http://purl.obolibrary.org/obo/HP_6000651	Abnormal metacarpal ossification	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		Any abnormal process of ossification of the metacarpal bones, which normally are each ossified from two centers: one for the body, and one for the head (metacarpal II,III,IV, and V) and one for the body and one for the base (metacarpal I). At the eighth to ninth week of fetal life, ossification commences in the middle of the body. At the third year the distal extremities of the metacarpals of the fingers and the base of the metacarpal of the thumb begin to ossify; they unite with the bodies at about the twentieth year.
http://purl.obolibrary.org/obo/HP_6000652	Rib spur	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		A bony projection (spur, osteophyte) originating from a rib.
http://purl.obolibrary.org/obo/HP_6000653	Crescent-shaped iliac bone	http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology		Deficient mineralization of the iliac wings, giving a paraglider/crescent shape to the iliac bone.
http://purl.obolibrary.org/obo/HP_6000654	Abnormal ischium ossification	http://purl.obolibrary.org/obo/HP_0003174	Abnormal ischium morphology		An abnormality of the formation and mineralization of ischial bones.
http://purl.obolibrary.org/obo/HP_6000655	Femoral neck fracture	http://purl.obolibrary.org/obo/HP_0031846	Femur fracture		A partial or complete breakage of the neck of femur.
http://purl.obolibrary.org/obo/HP_6000656	Papillary dermis eosinophilic hyaline material	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Accumulation of eosinophilic hyaline material observed around the papillary dermis and the blood vessels located in it. The papillary dermis is the uppermost layer of the dermis. It intertwines with the rete ridges of the epidermis and is composed of fine and loosely arranged collagen fibers.
http://purl.obolibrary.org/obo/HP_6000657	Pancreatic intraductal papillary mucinous neoplasm	http://purl.obolibrary.org/obo/HP_0002894	Neoplasm of the pancreas		Intraductal papillary mucinous neoplasm (IPMN) is an exocrine neoplasm of the pancreas consisting of epithelial cells growing within the pancreatic ducts (main pancreatic duct or its major branches) and producing mucin. IPMN is a mucin-producing pancreatic cystic tumor. IPMN contains epithelial cells that can create papillary projections.
http://purl.obolibrary.org/obo/HP_6000658	Medium vessel vasculitis	http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site		A type of vasculitis (inflammation of blood vessel walls) that affects medium-sized blood vessels. By common usage, vasculitis predominantly refers to arterial disease. Medium-sized vasculitis is observed in diseases including polyarteritis nodosa, Kawasaki disease, and cutaneous polyarteritis nodosa.
http://purl.obolibrary.org/obo/HP_6000659	Elevated muscle fiber laminin alpha 5 expression	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A decreased amount of laminin alpha-5 in muscle tissue. This feature can be shown by immunohistochemistry or Western blotting of muscle tissue. Laminin subunit alpha-5 is a protein encoded by the LAMA5 gene.
http://purl.obolibrary.org/obo/HP_6000660	Paravertebral mass	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		A swelling or enlargement localized next to the vertebral column. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000661	Phlebolith	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		A calcified structure that forms within a vein. The pathogenesis of phleboliths is thought to involve an organized thrombus produced when the peripheral blood flow slows. The thrombus calcifies, form- ing the core of the phlebolith. Then, the fibrinous com- ponent undergoes secondary calcification and becomes attached. Repetition of this process causes enlargement of the phlebolith.
http://purl.obolibrary.org/obo/HP_6000662	Bladder rupture	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		A perforation in the wall of the urinary bladder. Bladder rupture, a relatively rare condition, is most commonly due to abdominal or pelvic trauma but may be spontaneous or iatrogenic in association with surgical or endoscopic procedures. In most cases, patients with bladder rupture have gross hematuria. Other symptoms of bladder rupture include pelvic pain, lower abdominal pain, and difficulty voiding.
http://purl.obolibrary.org/obo/HP_6000663	Elevated myocardial iron load	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Increased amount of iron in myocardial tissue.
http://purl.obolibrary.org/obo/HP_6000664	Right ventricular regional wall motion abnormality	http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function		The occurrence of abnormal or absent contractility of a region of the heart muscle of the right ventricule. Conventional assessment of RWMA is based on visual interpretation of endocardial excursion and myocardial thickening from the echocardiogram videos.
http://purl.obolibrary.org/obo/HP_6000665	Right ventricular regional akinesia	http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function		A region of the right ventricle exhibits absent contraction (akinesia) compared to the rest of the ventricle.
http://purl.obolibrary.org/obo/HP_6000666	Right ventricular regional dyskinesia	http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function		A region of the right ventricle exhibits abnormal contraction (dyskinesia) compared to the rest of the ventricle, leading to outward bulging or ballooning during contraction or inadequate inward movement.
http://purl.obolibrary.org/obo/HP_6000667	Right ventricular aneurysm	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		A localized, abnormal dilation or bulging of a portion of the right ventricular wall.
http://purl.obolibrary.org/obo/HP_6000668	Glomerular immune-complex deposition	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Accumulation of immune deposits, containing immunoglobulins, complement, and other proteins, at various intraglomerular locations. This can lead to glomerulonephritis, with the type of injury that results being dependent on four factors: the mechanism of the deposit formation, the site of deposit formation, the composition of the deposits and the amount of the deposits.
http://purl.obolibrary.org/obo/HP_6000669	Glomerular PLA2R immune-complex deposition	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Accumulation of immune deposits, containing auto-antibodies against the podocyte antigen M-type phospholipase A2 receptor (PLA2R) in intraglomerular locations.
http://purl.obolibrary.org/obo/HP_6000670	Elevated urinary L-glycerate level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		The amount of L-glycerate in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000671	Breast myxoma	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		A rare, benign mesenchymal tumor of the breast characterized histologically by stellate, round, and spindle-shaped cells with vesicular nuclei and scant cytoplasm that are scattered in the myxoid stroma.
http://purl.obolibrary.org/obo/HP_6000672	Ovarian cystadenoma	http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm		A common, benign ovarian tumor that carries a good prognosis. The two most frequent types of cystadenomas are serous and mucinous cystadenomas whereas endometrioid and clear cell cystadenomas are rare.
http://purl.obolibrary.org/obo/HP_6000673	Abnormal CSF N-acetylaspartic acid concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Any deviation from the normal concentration of N-acetylaspartic acid in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_6000674	Decreased CSF N-acetylaspartic acid concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Concentration of N-acetylaspartic acid in the cerebrospinal fluid below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000675	Elevated urinary mevalonate lactone level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The amount of mevalonate lactone in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000676	Anti-von Willebrand factor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react to von Willebrand factor (VWF).
http://purl.obolibrary.org/obo/HP_6000677	Increased total natural killer cell count	http://purl.obolibrary.org/obo/HP_0040089	Abnormal total natural killer cell count		The absolute count of natural killer cells in the blood, per microlitre, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000679	Abnormal serum osmolality	http://purl.obolibrary.org/obo/HP_0011032	Abnormality of fluid regulation		Any deviation from the normal range of the serum osmolality, defined as the sum of the osmolalities of every single dissolved particle in the blood such as sodium and associated anions, potassium, glucose, and urea.
http://purl.obolibrary.org/obo/HP_6000680	Low serum osmolality	http://purl.obolibrary.org/obo/HP_6000679	Abnormal serum osmolality		Serum osmolality, which is defined as the sum of the osmolalities of every single dissolved particle in the blood such as sodium and associated anions, potassium, glucose, and urea, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000681	High serum osmolality	http://purl.obolibrary.org/obo/HP_6000679	Abnormal serum osmolality		Serum osmolality, which is defined as the sum of the osmolalities of every single dissolved particle in the blood such as sodium and associated anions, potassium, glucose, and urea, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000682	History of compressive dressings	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A past medical history of having been treated with tight bandages, compression sleeve, tight casts or splints, immobilizers, or similar items such as overly tight clothes, watch bands, or handcuffs.
http://purl.obolibrary.org/obo/HP_6000683	Triggered by overhead motions	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is induced by repeatedly performing overhead motions, such as painting a ceiling or working on objects located above the head, or some types of athletics.
http://purl.obolibrary.org/obo/HP_6000684	Radiating pain	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Pain that is perceived to extend or spread out from one area of the body to another.
http://purl.obolibrary.org/obo/HP_6000685	Mitral opening snap	http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound		Opening snap is an additional sound heard in the diastole that is related to the opening of a stenotic but mobile mitral valve. It is described as an early diastolic, high-pitched sound, which is associated with opening of the mitral and/or tricuspid valve.
http://purl.obolibrary.org/obo/HP_6000686	Mucus in stool	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Abnormally increased amount of mucus in the feces. Mucus is a slippery aqueous secretion produced by mucous membranes including those of the intestines.
http://purl.obolibrary.org/obo/HP_6000687	Elevated circulating CCL3 concentration	http://purl.obolibrary.org/obo/HP_6000446	Abnormal circulating CC chemokine concentration		The concentration of C-C Motif Ligand 3 (CCL3) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000688	Elevated circulating CCL4 concentration	http://purl.obolibrary.org/obo/HP_6000446	Abnormal circulating CC chemokine concentration		The concentration of C-C Motif Ligand 4 (CCL4) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000689	Elevated CSF 14-3-3 protein concentration	http://purl.obolibrary.org/obo/HP_6000205	Elevated CSF myelin basic protein concentration		The concentration of 14-3-3 protein in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000690	Elevated CSF dihydrobiopterin concentration	http://purl.obolibrary.org/obo/HP_0040207	Abnormal CSF pterin concentration		Concentration of dihydrobiopterin in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000691	Left atrial fibrosis	http://purl.obolibrary.org/obo/HP_0025579	Abnormal left atrium morphology		Atrial fibrosis is an hallmark of atrial structural remodelling, characterized by the aberrant activation, proliferation and differentiation of fibroblasts, and subsequent excessive synthesis and irregular deposition of extracellular matrix proteins.
http://purl.obolibrary.org/obo/HP_6000693	Decreased circulating NT-proANP concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of NT-proANP (= N-terminal proatrial natriuretic peptide) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000694	Elevated circulating 1-pyrroline-5-carboxylic acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of delta-1-pyrroline-5-carboxylate in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000695	Reduced tissue delta-1-pyrroline-5-carboxylate dehydrogenase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH; EC 1.5.1.12) below the lower limit of normal. P5CDH can be measured in multiple tissues including leukocytes and cultured fibroblasts. P5CDH is a mitochondrial matrix NAD(+)-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate.
http://purl.obolibrary.org/obo/HP_6000696	Elevated circulating N-carbamyl-beta-aminoisobutyric acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of N-carbamyl-beta-aminoisobutyric acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000697	Low tissue ferrochelatase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of Ferrochelatase (FECH; EC 4.99.1.1) below the lower limit of normal. FECH enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts. FECH is the terminal enzyme of the heme biosynthetic pathway, and catalyzes the insertion of iron into protoporphyrin to form heme.
http://purl.obolibrary.org/obo/HP_6000698	Elevated circulating heptacarboxylporphyrin concentration	http://purl.obolibrary.org/obo/HP_0034606	Elevated circulating porphyrin concentration		The concentration of heptacarboxylporphyrin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000699	Aggravated by menstruation	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is more severe during mensutruation.
http://purl.obolibrary.org/obo/HP_6000700	Reduced breast milk zinc concentration	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		The concentration of zinc in breast milk is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000701	Elevated urinary bile acid level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		The amount of bile acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000702	Elevated urinary glyoxylic acid level	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		The amount of glyoxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal. The conjugate base of glyoxylic acid is known as glyoxylate.
http://purl.obolibrary.org/obo/HP_6000703	Elevated circulating 3-hydroxyanthranilic acid concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		The concentration of 3-hydroxyanthranilic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000704	Elevated circulating CXCL9 concentration	http://purl.obolibrary.org/obo/HP_0011112	Abnormal circulating cytokine concentration		The concentration of chemokine (C-X-C motif) ligand 9 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/PATO_0103000	quantitative	http://purl.obolibrary.org/obo/PATO_0000001	quality		A quality of an entity that can be represented numerically, including anything that can be counted, measured, or given a numerical value.
http://purl.obolibrary.org/obo/UBERON_8600120	atrial intrinsic cardiac ganglion	http://purl.obolibrary.org/obo/UBERON_0014463	cardiac ganglion		A ganglion that is part of the atrial region of the heart. The activation of efferent neurons in this ganglion results in the modulation of heart rate, atrio-ventricular node conduction, and inotropism of atria and ventricles.
http://purl.obolibrary.org/obo/UBERON_8600123	lower airway ganglion	http://purl.obolibrary.org/obo/UBERON_0001808	parasympathetic ganglion		A parasympathetic ganglion that is located within the airway walls of the lower respiratory tract. This ganglion is responsible for controlling the constriction of the airway by stimulating smooth muscle contraction in the lower respiratory tract to regulate airflow.
http://purl.obolibrary.org/obo/UBERON_8600124	fallopian tube epithelium	http://purl.obolibrary.org/obo/UBERON_0012274	columnar epithelium		A simple columnar epithelium that is part of the fallopian tube.
http://purl.obolibrary.org/obo/HP_0020015	Amyloid deposition by anatomical site	http://purl.obolibrary.org/obo/HP_0011034	Amyloid deposition		Amyloid deposition categorized according to the anatomical site of deposition.
http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology	http://purl.obolibrary.org/obo/HP_0009811	Abnormality of the elbow		A structural anomaly of the joint that connects the upper and the lower arm.
http://purl.obolibrary.org/obo/HP_0020301	Abnormal elbow physiology	http://purl.obolibrary.org/obo/HP_0009811	Abnormality of the elbow		A functional anomaly of the joint that connects the upper and the lower arm.
http://purl.obolibrary.org/obo/HP_6001426	Elbow instability	http://purl.obolibrary.org/obo/HP_0020301	Abnormal elbow physiology		Impairment of the ability of the elbow joint to maintain proper anatomical alignment and functional mechanics. Elbow instability is a spectrum from subluxation to dislocation, with corresponding clinical and pathologic features and therapeutic implications.
http://purl.obolibrary.org/obo/HP_0020029	Abnormal spinal cord white matter morphology	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		Any structural abnormality affecting the white matter of the spinal cord, including sensory tracts (dorsal columns) and motor tracts (corticospinal tracts). Abnormalities may involve myelin, axons, or tract organization and can result in sensory, motor, or autonomic deficits.
http://purl.obolibrary.org/obo/HP_0020008	History of disease onset in winter	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		The initial manifestation of a disease or symptom occurring during the winter season.
http://purl.obolibrary.org/obo/HP_0020009	History of disease onset in summer	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		The initial manifestation of a disease or symptom occurring during the summer season.
http://purl.obolibrary.org/obo/HP_0020010	Cutaneous lesion morphology	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		A description of structural or physical characteristics of a skin lesion, describing how the lesion appears or is composed.
http://purl.obolibrary.org/obo/HP_0020011	Bleeding into skin lesions	http://purl.obolibrary.org/obo/HP_0020010	Cutaneous lesion morphology		Presence of bleeding within (pre-existing) cutaneous lesions such as blisters or vesicles, resulting in blood-filled lesions.
http://purl.obolibrary.org/obo/HP_0020012	Crusted skin lesions	http://purl.obolibrary.org/obo/HP_0020010	Cutaneous lesion morphology		Lesions covered by a hardened layer of dried exudate, blood, or serum.
http://purl.obolibrary.org/obo/HP_0020013	Slough	http://purl.obolibrary.org/obo/HP_0033126	Cutaneous necrosis		Slough is a type of necrotic skin lesion that is characterized as being yellow, tan, green or brown in color and may be moist, loose and stringy in appearance.
http://purl.obolibrary.org/obo/HP_0020014	Local paresthesia at bite site	http://purl.obolibrary.org/obo/HP_0003401	Paresthesia		Abnormal tingling, burning, or itching sensation localized to the site of an animal bite, typically occurring after the wound has healed.
http://purl.obolibrary.org/obo/HP_0020016	Amyloid deposition by type of amyloid	http://purl.obolibrary.org/obo/HP_0011034	Amyloid deposition		Amyloid deposition categorized according to the category of pathological amyloid fiber being deposited.
http://purl.obolibrary.org/obo/HP_0020017	Transthyretin amyloid deposition	http://purl.obolibrary.org/obo/HP_0020016	Amyloid deposition by type of amyloid		Deposition of misfolded transthyretin (TTR) protein in tissue.
http://purl.obolibrary.org/obo/HP_0020018	Cerebral transthyretin amyloid deposition	http://purl.obolibrary.org/obo/HP_0020017	Transthyretin amyloid deposition		Accumulation of misfolded transthyretin protein in brain tissue.
http://purl.obolibrary.org/obo/HP_0020019	Abnormal CSF 5-hydroxyindoleacetic acid concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		The concentration of 5-hydroxyindoleacetic acid in the cerebrospinal fluid (CSF) is above or below the limits of normal.
http://purl.obolibrary.org/obo/HP_0020020	Decreased CSF 5-hydroxyindoleacetic acid concentration	http://purl.obolibrary.org/obo/HP_0020019	Abnormal CSF 5-hydroxyindoleacetic acid concentration		The concentration of 5-hydroxyindoleacetic acid in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0020021	Hip external rotation contracture	http://purl.obolibrary.org/obo/HP_0003273	Hip contracture		A condition where the hip joint is limited in its range of motion due to the shortening of muscles that externally rotate the hip, causing the leg and foot to point outward when standing or walking. The knee is turned past neutral in the direction moving away from the midline, where the neutral position for the hip is with knee pointing directly anteriorly.
http://purl.obolibrary.org/obo/HP_0020022	Hip abduction contracture	http://purl.obolibrary.org/obo/HP_0003273	Hip contracture		Abduction contracture of the hip is characterized by the limitation of active and/or passive adduction of the hip joint in the coronal plane; a chronic reduction in the ability to move the proximal segment of the lower extremity actively or passively medially towards the body midline past the sagittal plane of the body.
http://purl.obolibrary.org/obo/HP_0020023	Hip adduction contracture	http://purl.obolibrary.org/obo/HP_0003273	Hip contracture		Inability of hip to bring from medial side to neutral position, where the neutral position for the hip is with the thigh segment in line with the anatomic plane of the pelvis, both in the coronal and sagittal planes.
http://purl.obolibrary.org/obo/HP_0020024	Hip extension contracture	http://purl.obolibrary.org/obo/HP_0003273	Hip contracture		Inability to flex the hip past the extension range from the neutral position, where the neutral position for the hip is with the hip and thigh segment in line in the same coronal plane as the pelvis.
http://purl.obolibrary.org/obo/HP_0020025	Hip flexion contracture	http://purl.obolibrary.org/obo/HP_0003273	Hip contracture		The inability to bring a flexed hip to neutral in the sagittal plane, where the neutral position for the hip is with the thigh segment in line with the anatomic plane of the pelvis, both in the coronal and sagittal planes.
http://purl.obolibrary.org/obo/HP_0020026	Positive Coombs test	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		A positive (abnormal) result of the direct antiglobulin test (DAT; sometimes referred to as the Coombs test). The test is a method of demonstrating the presence of antibody or complement bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction. The DAT tests for antibodies or complement bound directly to erythrocytes, indicating in vivo sensitization.
http://purl.obolibrary.org/obo/HP_0020027	Direct antiglobulin test positive for IgG	http://purl.obolibrary.org/obo/HP_0020026	Positive Coombs test		Demonstration of the presence of IgG antibodies bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction.
http://purl.obolibrary.org/obo/HP_0020028	Direct antiglobulin test positive for IgM	http://purl.obolibrary.org/obo/HP_0020026	Positive Coombs test		Demonstration of the presence of IgM antibodies bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction.
http://purl.obolibrary.org/obo/HP_0020030	Abnormal spinal cord lateral corticospinal tract morphology	http://purl.obolibrary.org/obo/HP_0020029	Abnormal spinal cord white matter morphology		Any structural abnormality affecting the lateral corticospinal tracts of the spinal cord, which may involve axonal loss, demyelination, or tract degeneration, and can result in motor deficits such as weakness, spasticity, or impaired voluntary movement.
http://purl.obolibrary.org/obo/HP_0020031	Direct antiglobulin test positive for C3d	http://purl.obolibrary.org/obo/HP_0020026	Positive Coombs test		Demonstration of the presence of C3d complement fragments bound to red blood cell (RBC) membranes using anti-human globulin (Coombs reagent), which produces a visible agglutination reaction.
http://purl.obolibrary.org/obo/HP_0020032	Hyperreflective retinal dots on OCT	http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT		Abnormal hyperreflective dots (HRDs) detected in Optical coherence tomography (OCT) scans. The HRDs are scattered, punctiform, small in size, mainly located in the outer retinal layers and/or around pockets of fluid accumulation and are typically not confluent.
http://purl.obolibrary.org/obo/HP_0020033	Irregularity of the retinal pigment epithelium layer on OCT	http://purl.obolibrary.org/obo/HP_0030603	Abnormal optical coherence tomography		Lack of uniformity in the morphology of the retinal pigment epithelium (RPE) layer observed on optical coherence tomography (OCT) imaging. The RPE lies between the neurosensory retina (photoreceptors) and Bruch membrane/choroid, and normally appears as a thin, hyperreflective (bright) band on OCT imaging. This term comprises irregularities which may manifest as thickening, thinning, undulations, or loss of normal reflectivity, potentially affecting retinal structure or function.
http://purl.obolibrary.org/obo/HP_0020039	Retinal thickening on OCT	http://purl.obolibrary.org/obo/HP_0020040	Abnormal anteroposterior retina thickness on OCT		Anteroposterior thickness of the retina above the upper limit of normal. This phenotype can be appreciated by retinal optical coherence tomography (OCT).
http://purl.obolibrary.org/obo/HP_0020040	Abnormal anteroposterior retina thickness on OCT	http://purl.obolibrary.org/obo/HP_0030603	Abnormal optical coherence tomography		Anteroposterior thickness of the retina outside the limits of normal. This phenotype can be appreciated by retinal optical coherence tomography (OCT).
http://purl.obolibrary.org/obo/HP_0020051	Abnormal seminiferous tubule morphology	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Any anomaly in the structure or density (count of tubules per volume) of the seminiferous tubules, i.e., the coiled structures within the testis that contain Sertoli cells, which support and nurture germ cells as they develop into mature spermatozoa.
http://purl.obolibrary.org/obo/HP_0020052	Necrotizing lymph node granuloma	http://purl.obolibrary.org/obo/HP_0020229	Abnormal lymph-node biospecimen		A granuloma located within a lymph node that is associated with necrosis. Usually, the necrosis is surrounded by collections of histiocytes. A granuloma is a focal aggregate of immune cells that forms in response to a persistent inflammatory stimulus. It characteristically demonstrates the compact organization of mature macrophages, which may or may not be associated with other inflammatory cell types.
http://purl.obolibrary.org/obo/HP_0020053	Abnormal marker expression	http://purl.obolibrary.org/obo/HP_0020228	Biospecimen phenotypic feature		Aberrant marker expression is a phenomenon of abnormal gain or loss of lineage specific or associated antigens. It involves changes in the presence, absence, quantity, or localization of molecular or immunohistochemical markers.
http://purl.obolibrary.org/obo/HP_0020055	Diminished MLH1 expression	http://purl.obolibrary.org/obo/HP_0020053	Abnormal marker expression		Immunohistochemistry (IHC) demonstrating loss of expression of the mismatch repair gene product mutL homolog 1 (MLH1).
http://purl.obolibrary.org/obo/HP_0020056	Diminished MSH2 expression	http://purl.obolibrary.org/obo/HP_0020053	Abnormal marker expression		Immunohistochemistry (IHC) demonstrating loss of expression of the mismatch repair gene product mutS homolog 2 (MSH2).
http://purl.obolibrary.org/obo/HP_0020057	Diminished MSH6 expression	http://purl.obolibrary.org/obo/HP_0020053	Abnormal marker expression		Immunohistochemistry (IHC) demonstrating loss of expression of the mismatch repair gene product mutS homolog 6 (MSH6).
http://purl.obolibrary.org/obo/HP_0020065	Diminished PMS2 expression	http://purl.obolibrary.org/obo/HP_0020053	Abnormal marker expression		Immunohistochemistry (IHC) demonstrating loss of expression of the mismatch repair gene product PMS1 homolog 2 (PMS2).
http://purl.obolibrary.org/obo/HP_0020068	Intranuclear inclusion bodies	http://purl.obolibrary.org/obo/HP_0020066	Pathological inclusion body by subcellular location		Inclusion bodies (deposits of stainable material, usually misfolded proteins) localized in the nucleus.
http://purl.obolibrary.org/obo/HP_0020069	Appendicular location	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to a lesion that is localized on the arm or leg.
http://purl.obolibrary.org/obo/HP_0020070	Exposure to humid conditions	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of living in an environment characterized by excess moisture and heat, tropical conditions, or muggy weather.
http://purl.obolibrary.org/obo/HP_0020092	Histopathological abnormality	http://purl.obolibrary.org/obo/HP_0020228	Biospecimen phenotypic feature		Any microscopic alteration in the cellular or tissue morphology of a biospecimen, identified through histologic examination, including changes in differentiation, organization, or cytologic features.
http://purl.obolibrary.org/obo/HP_0020094	Squamous metaplasia	http://purl.obolibrary.org/obo/HP_0020092	Histopathological abnormality		Metaplasia of an epithelium (normally a unilayer of cuboidal or columnar cells) with squamous epithelium (squamous means scale-like). Metaplastic squamous epithelium becomes stratified (i.e., has multiple layers).
http://purl.obolibrary.org/obo/HP_0020109	Glomerular basement membrane duplication	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Glomerular basement membrane duplication (GBM-DP) can be seen with Periodic acid-Schiff and silver stains. This appearance results from the presence of subendothelial deposits and the so-called mesangial interposition whereby mesangial cells, infiltrating mononuclear cells, or even portions of endothelial cells interpose themselves between the endothelium and basement membrane, with new, inner GBM-like material being laid down. This produces a double contour or tram-track appearance on light or electron microscopy. This finding often reflects splitting of the lamina densa and is associated with disease processes such as membranoproliferative glomerulonephritis, transplant glomerulopathy, and diabetic nephropathy.
http://purl.obolibrary.org/obo/HP_0020115	Abnormal CD8+ T cell subset proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Abnormal increase or decrease of any CD8+ T cell subpopulation, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0020116	Subcutaneous abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A circumscribed area of pus or necrotic debris located in the subcutaneous tissue (subcutaneous fat layer), below the dermis.
http://purl.obolibrary.org/obo/HP_0020162	Abnormal neoplastic cell morphology	http://purl.obolibrary.org/obo/HP_0020092	Histopathological abnormality		A morphological abnormality of of tumor or neoplastic cells, characterized by atypical size, shape, cytoplasmic or nuclear features, or other deviations from normal cellular architecture.
http://purl.obolibrary.org/obo/HP_0020168	Tumor signet ring cell	http://purl.obolibrary.org/obo/HP_0020162	Abnormal neoplastic cell morphology		A signet ring has a flattened surface at the top of the ring with an engraved or raised symbol, historically used to stamp a seal into correspondence. Comparatively, these cells acquire a signet cell morphology due to accumulation of abundant mucin in cytoplasm, leading to nuclei dislocation to the periphery.
http://purl.obolibrary.org/obo/HP_0020232	Abnormal Q wave	http://purl.obolibrary.org/obo/HP_0025074	Abnormal QRS complex		An anomaly of the Q wave of the electrocardiogram.
http://purl.obolibrary.org/obo/HP_0020252	Abnormal bursal fluid morphology	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		An anomaly of the synovial-like fluid found within a bursa, which is a small, closed sac lined by synovial membrane that reduces friction between tissues such as tendons, muscles, ligaments, and bones.
http://purl.obolibrary.org/obo/HP_0020256	Elevated bursal fluid leukocyte count	http://purl.obolibrary.org/obo/HP_0020252	Abnormal bursal fluid morphology		The count of leukocytes per unit volume in a bursa aspirate specimen is above the uppper limit of normal.
http://purl.obolibrary.org/obo/HP_0020259	Decreased biparietal diameter	http://purl.obolibrary.org/obo/HP_6001417	Abnormal biparietal diameter		Fetal head width measurement, taken between the outer edge of the proximal parietal bone and the inner edge of the distal parietal bone, below the lower limit of normal, usually taken to be two standard deviations below the norm or above the 3rd percentile for the gestational age.
http://purl.obolibrary.org/obo/HP_6001417	Abnormal biparietal diameter	http://purl.obolibrary.org/obo/HP_0034245	Fetal head anomaly		Abnormal biparietal diameter (BPD) refers to a fetal head width measurement, taken between the outer edge of the proximal parietal bone and the inner edge of the distal parietal bone on an ultrasound image, that lies outside the expected range for a given gestational age. The expected range typically falls between the 10th and 90th percentiles, with microcephaly defined as a BPD below the 3rd percentile (or more than 2 standard deviations below the mean) and macrocephaly defined as a BPD above the 97th percentile (or more than 2 standard deviations above the mean).
http://purl.obolibrary.org/obo/HP_0020260	Increased biparietal diameter	http://purl.obolibrary.org/obo/HP_6001417	Abnormal biparietal diameter		Fetal head width measurement, taken between the outer edge of the proximal parietal bone and the inner edge of the distal parietal bone, above the upper limit of normal, usually taken to be two standard deviations above the norm or above the 97th percentile for the gestational age.
http://purl.obolibrary.org/obo/HP_0020297	Abnormal occipitofrontal diameter	http://purl.obolibrary.org/obo/HP_0034245	Fetal head anomaly		Abnormal occipitofrontal diameter (OFD) refers to a fetal head width measurement, taken between the root of the nose to the most prominent part of the occiput on an ultrasound image that lies outside the expected range for a given gestational age. The expected range typically falls between the 3rd percentile (or more than 2 standard deviations below the mean) and the 97th percentile (or more than 2 standard deviations above the mean).
http://purl.obolibrary.org/obo/HP_0020298	Decreased occipitofrontal diameter	http://purl.obolibrary.org/obo/HP_0020297	Abnormal occipitofrontal diameter		Occipitofrontal diameter, measured with fetal sonography, below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0020299	Increased occipitofrontal diameter	http://purl.obolibrary.org/obo/HP_0020297	Abnormal occipitofrontal diameter		Occipitofrontal diameter, measured with fetal sonography, above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020302	Restrictive eating	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		A behavioral pattern characterized by a deliberate and sustained limitation of food intake, often involving avoidance of certain foods, restriction of portion size, or prolonged fasting, resulting in reduced energy or nutrient consumption relative to physiological needs.
http://purl.obolibrary.org/obo/HP_0020303	Abnormal fetal abdominal circumference	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Any deviation from the normal range of the fetal abdominal circumference, which is typically measured sonographically in a transverse view using the outer borders of the skin line at the plane where the fetal stomach, umbilical vein and portal sinus is visible. Abnormal fetal abdominal circumference is defined as less than the 10th or greater than the 90th percentile for gestational age.
http://purl.obolibrary.org/obo/HP_0020304	Increased fetal abdominal circumference	http://purl.obolibrary.org/obo/HP_0020303	Abnormal fetal abdominal circumference		The distance around the abdomen of a fetus, generally as measured by prenatal sonography, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020305	Abnormal fetal head circumference	http://purl.obolibrary.org/obo/HP_0034245	Fetal head anomaly		Any deviation from the normal range of the fetal head circumference, which is typically measured sonographically in the axial plane at the level of the thalami and cavum septic pellucidi, using the outer border of the bony calvarium. Abnormal fetal head circumference is defined as less than the thrid percentile or 2 standard deviations below the mean or greater than the 97the percentile or 2 standard deviations above the mean.
http://purl.obolibrary.org/obo/HP_0020306	Decreased fetal head circumference	http://purl.obolibrary.org/obo/HP_0020305	Abnormal fetal head circumference		Fetal head circumference less than the third percentile or 2 standard deviations below the mean.
http://purl.obolibrary.org/obo/HP_0020307	Increased fetal head circumference	http://purl.obolibrary.org/obo/HP_0020305	Abnormal fetal head circumference		Fetal head circumference above the 97th percentile or 2 standard deviations above the mean.
http://purl.obolibrary.org/obo/HP_5000040	Distal radioulnar joint space widening	http://purl.obolibrary.org/obo/HP_0006439	Radioulnar dislocation		Increased space between the distal radius and distal ulna at sigmoid notch (radioulnar distance more than 6 mm at the sigmoid notch).
http://purl.obolibrary.org/obo/HP_5000049	Distal radioulnar joint translation	http://purl.obolibrary.org/obo/HP_0006439	Radioulnar dislocation		Abnormal linear movement or displacement of the ulnar head relative to the radius at the wrist, indicating instability of the distal radioulnar joint, which is the distal articulation between the radius and ulna, acting as a major weight-bearing joint at the wrist and distributing forces across the forearm bones.
http://purl.obolibrary.org/obo/HP_6001360	Hyperlordotic gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		A gait abnormality characterized by excessive lumbar lordosis (swayback posture, i.e., an inward curvature of the lower spine) and gait pattern with forward tilt of the pelvis and increased lumbar curvature. Hyperlordotic gait is often as a compensatory mechanism for hip extensor weakness, proximal muscle weakness, or hip flexion contracture.
http://purl.obolibrary.org/obo/HP_6001361	Radioulnar interosseous membrane tear	http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius		A tear in the fibrous sheet connecting the radius and ulna bones in the forearm.
http://purl.obolibrary.org/obo/HP_6001362	Fleck sign of elbow	http://purl.obolibrary.org/obo/HP_0004032	Abnormal olecranon morphology		A radiograpzhic sign in which small bone fragments detached from the olecranon are seen on lateral radiographs in cases with avulsion of the tendon.
http://purl.obolibrary.org/obo/HP_6001363	Resisted wrist flexion provokes pain	http://purl.obolibrary.org/obo/HP_0030836	Wrist pain		Active wrist flexion against resistance increases pain in the arm.
http://purl.obolibrary.org/obo/HP_6001364	Lateral epicondylitis of the elbow	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		A chronic symptomatic degeneration of the wrist extensor tendons involving their attachment to the lateral epicondyle of the humerus, and is associated clinically with lateral elbow pain (tennis elbow). This term refers to the associated imaging finding. Ultrasound imaging showing extensor carpi radialis brevis (ECRB) tendon thickening and hypoechoic areas with increased vascularity or MRI showing increased signal intensity or tear at the insertion site of the ECRB on the lateral aspect of the elbow.
http://purl.obolibrary.org/obo/HP_6001365	Medial epicondylitis of the elbow	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		Medial epicondylitis, often referred to as golfer's elbow, is a common pathology. Flexor-pronator tendon degeneration occurs with repetitive forced wrist extension and forearm supination during activities involving wrist flexion and forearm pronation. This term refers to the associated imaging finding. Ultrasound imaging showing ECRB tendon thickening and hypoechoic areas with increased vascularity or MRI showing increased signal intensity or tear at the insertion site of the common flexor tendon.
http://purl.obolibrary.org/obo/HP_6001366	Popeye sign	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		Exaggerated bulging of the belly of the biceps muscle upon contraction.
http://purl.obolibrary.org/obo/HP_6001367	Distal biceps tendon rupture	http://purl.obolibrary.org/obo/HP_6001262	Biceps tendon rupture		Rupture (tear) of the distal biceps tendon. Ultrasound imaging showing complete discontinuity of the distal biceps tendon or MRI revealing complete distal biceps tendon discontinuity or increased signal intensity in the distal biceps tendon.
http://purl.obolibrary.org/obo/HP_6001368	Proximal biceps tendon rupture	http://purl.obolibrary.org/obo/HP_6001262	Biceps tendon rupture		Rupture (tear) of the proximal biceps tendon. MRI reveals a tear of the proximal aspect of the biceps tendon near its site of origin at the supraglenoid tubercle.
http://purl.obolibrary.org/obo/HP_6001369	Positive bursal fluid infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Detection of an infectious agent, or evidence thereof, in aspirated bursal fluid using microbiological, molecular, or antigen-based testing methods.
http://purl.obolibrary.org/obo/HP_6001370	Acute retinal necrosis	http://purl.obolibrary.org/obo/HP_5210265	Severe retinitis		A condition characterized by the death of retinal tissue due to ischemia, infection, or inflammation.
http://purl.obolibrary.org/obo/HP_6001371	Cystic changes in greater tuberosity of the humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		Cystic lesions of the proximal humerus are commonly encountered on routine shoulder magnetic resonance imaging (MRI). True cysts are defined as fluid-filled structures or lesions with an epithelial lining, whereas pseudocysts are fluid-filled lesions without epithelial lining. Cystic lesion encompasses both true cysts, pseudocysts and other lesions which could mimic the appearance of a cyst on MRI, with increased signal on fluid sensitive sequences.
http://purl.obolibrary.org/obo/HP_6001372	Positive Hawkins test	http://purl.obolibrary.org/obo/HP_0025823	Positive provocative functional shoulder test		Manual internal rotation on the forearm with the shoulders flexed forward to 90 degrees, elbows bent to 90 degrees so that the forearm is parallel to the ground, and palm facing down recreates pain in the shoulder region; named after Dr. Hawkins.
http://purl.obolibrary.org/obo/HP_6001373	Hallux weakness	http://purl.obolibrary.org/obo/HP_0003690	Limb muscle weakness		Reduced ability to exert force or power with the hallux (big toe), i.e., reduced strength of the hallux.
http://purl.obolibrary.org/obo/HP_6001374	Hallux dorsiflexion weakness	http://purl.obolibrary.org/obo/HP_0003690	Limb muscle weakness		Reduced ability to lift the big toe (hallux) upward toward the shin.
http://purl.obolibrary.org/obo/HP_6001375	Hallux plantarflexion weakness	http://purl.obolibrary.org/obo/HP_0003690	Limb muscle weakness		Reduced ability to push the big toe (hallux) downward, away from the shin.
http://purl.obolibrary.org/obo/HP_6001376	Forefoot pain	http://purl.obolibrary.org/obo/HP_0025238	Foot pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized about the metatarsal heads in the front part of the foot.
http://purl.obolibrary.org/obo/HP_6001377	Spur at inferior pole of patella	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		A bone spur (osteophyte), i.e., de novo bone formation at the lower edge of the patella (knee cap). Radiographically, it is visible as calcification at inferior pole of the patella.
http://purl.obolibrary.org/obo/HP_6001378	Urinary ascites	http://purl.obolibrary.org/obo/HP_0001541	Ascites		The presence of urine in the peritoneal cavity, an entity that typically results from bladder rupture or damage to the ureters.
http://purl.obolibrary.org/obo/HP_6001379	Abnormal mixed venous oxygen saturation	http://purl.obolibrary.org/obo/HP_0500165	Abnormal blood oxygen level		Abnormal oxygen saturation in mixed venous blood (SvO2). SvO2 can be measured in a sample of mixed venous blood drawn from the distal lumen of a catheter placed in the pulmonary artery. The SvO2 is dependent on arterial oxygen saturation, hemoglobin concentration, cardiac output, and tissue oxygen demands.
http://purl.obolibrary.org/obo/HP_6001380	Elevated circulating lysosphingomyelin concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		The concentration of lysosphingomyelin in the blood circulation is above the upper limit of normal. Acid sphingomyelinase deficiency (ASMD) or Niemann-Pick type A/B is a lysosomal disorder caused by the deficiency of acid sphingomyelinase (ASM) due to pathogenic variants in the SMPD1 gene. Sphingomyelin (SM) is the substrate for ASM that cleaves the phosphorylcholine linkage of SM producing ceramide. SM is a major compound of most cell membranes and coupled with cholesterol constitutes most of the membrane rafts. In the deficiency of ASM, there is primary storage of SM, and the concentration of lysosphingomyelin in dried blood spots and in the blood circulation is typically elevated.
http://purl.obolibrary.org/obo/HP_6001381	Abnormal lens capsule morphology	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		A structural anomaly of the lens capsule, the smooth, transparent, acellular basement membrane that envelops the lens of the eye and serves as the attachment site for the lens zonules and the lens epithelium.
http://purl.obolibrary.org/obo/HP_6001382	Posterior capsule opacification	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		Posterior capsule opacification, also known as secondary cataract, is the most frequent complication following manual extracapsular cataract extraction. Secondary cataract results from the proliferation and migration of residual epithelial cells in the posterior region of the lens capsule into the visual axis, leading to thickening and reduction in transparency (opacification), which in turn can cause a decrease in visual acuity.
http://purl.obolibrary.org/obo/HP_6001383	Bronchial stenosis	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		A narrowing (constriction) of the lumen of a bronchus, which may involve one or more of the major airways branching from the trachea.
http://purl.obolibrary.org/obo/HP_6001384	Skin tenting due to fracture	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Skin tenting may occur in the setting of a fracture when a displaced bone fragment pushes on the skin, causing it to bulge outward in a tent-like shape.
http://purl.obolibrary.org/obo/HP_6001385	Follicular conjunctivitis	http://purl.obolibrary.org/obo/HP_0000509	Conjunctivitis		A type of conjunctivitis characterized by the formation of conjunctival follicles, which appear as raised domes on the are round collections of lymphocytes, and are often most prominent in the inferior fornix (interior part of the lower eyelid).
http://purl.obolibrary.org/obo/HP_6001386	Granulomatous conjunctivitis	http://purl.obolibrary.org/obo/HP_0000509	Conjunctivitis		A type of conjunctivitis characterized by the formation of conjunctival granulomata, i.e., localized nodular inflammatory lesions of the conjunctiva, characterized histologically by aggregates of epithelioid histiocytes, often with multinucleated giant cells, surrounded by lymphocytes and fibroblasts.
http://purl.obolibrary.org/obo/HP_6001387	Areas of hypopigmentation and hyperpigmentation that follow Blaschko lines	http://purl.obolibrary.org/obo/HP_0009123	Mixed hypo- and hyperpigmentation of the skin		Linear streaks of hypopigmentation or hyperpigmentation that are distributed according to Blaschko lines, which are V-shaped, S-shaped, or linear patterns on the skin that reflect the embryonic migration pathways of epidermal cells (keratinocytes, melanocytes, etc.) during early development.
http://purl.obolibrary.org/obo/HP_6001388	Retinal drusen	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Small focal extracellular deposits underneath the retina, visible ophthalmoscopically as yellow dots.
http://purl.obolibrary.org/obo/HP_6001389	Intrauterine amputation	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		A developmental anomaly characterized by partial or complete absence of a limb or digit at birth, resulting from interruption of normal limb development in utero.
http://purl.obolibrary.org/obo/HP_6001390	Intrauterine digital amputation	http://purl.obolibrary.org/obo/HP_6001389	Intrauterine amputation		A developmental anomaly characterized by partial or complete absence of a finger or toe at birth, resulting from interruption of normal development in utero.
http://purl.obolibrary.org/obo/HP_6001391	Intrauterine limb amputation	http://purl.obolibrary.org/obo/HP_6001389	Intrauterine amputation		A developmental anomaly characterized by partial or complete absence of an arm or leg at birth, resulting from interruption of normal development in utero.
http://purl.obolibrary.org/obo/HP_6001392	Proximal interphalangeal joint arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		Inflammation and deterioration of the proximal interphalangeal (PIP) joints. Radiographically, PIP arthritis can be characterized by PIP joint space narrowing, subchondral cysts, and osteophytes.
http://purl.obolibrary.org/obo/HP_6001393	Dorsal intercalated segment instability	http://purl.obolibrary.org/obo/HP_0025799	Abnormal wrist physiology		A nondissociative form of carpal instability, in which the lunate bone angulates to the dorsal side of the hand.
http://purl.obolibrary.org/obo/HP_6001394	Disruption of carpal arcs	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		The arcs of the Gilula are used on PA wrist radiographs as part of assessing the normal alignment of the carpus. The 1st arc (red) outlines the proximal surfaces and the 2nd arc (yellow) the distal surfaces of the scaphoid, lunate and triquetrum. The 3rd arc (white) outlines the proximal surfaces of the capitate and hamate. Disruption of carpal arcs (i.e., the arcs appear broken or discontinuous on radiographs) indicates a fracture or ligamentous injury in the wrist.
http://purl.obolibrary.org/obo/HP_6001395	Spilled teacup sign of the wrist	http://purl.obolibrary.org/obo/HP_0004248	Abnormal lunate bone morphology		Dislocation of the lunate bone, generally as a result of trauma. Volar displacement of the lunate is said to result a tipped teacup.
http://purl.obolibrary.org/obo/HP_6001396	Positive Finkelstein sign	http://purl.obolibrary.org/obo/HP_0025799	Abnormal wrist physiology		Finkelstein's test produces severe tenderness and usually pain on the radial aspect of the wrist when the thumb is flexed into the palm and the wrist is ulnar deviated.
http://purl.obolibrary.org/obo/HP_6001397	Forefoot abduction	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		Outward deviation or turning of the front part of the foot away from the body's midline. An anteroposterior foot x-ray shows increased Simmon angle (angle between the talus and first metatarsal, normal is 7 degrees plus/minus 4 to 5 degrees) or increased talonavicular uncoverage of over 30 to 40 percent. A common clinical observation is the too many toes sign; when viewed from behind, more than two toes will flare out laterally due to the valgus alignment of the foot.
http://purl.obolibrary.org/obo/HP_6001398	Posterior tibial tendon injury	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		Damage to the posterior tibialis tendon, which runs along the inside of the ankle and foot, supporting the arch of the foot. MRI or ultrasound of the ankle/foot shows posterior tibial tendon degeneration such as tendinosis, tenosynovitis, edema around the tendon, or tendon tear.
http://purl.obolibrary.org/obo/HP_6001399	Plantar pain	http://purl.obolibrary.org/obo/HP_0025238	Foot pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to palpation of plantar aspect of the foot (the sole).
http://purl.obolibrary.org/obo/HP_6001400	Flexor hallucis longus tendon injury	http://purl.obolibrary.org/obo/HP_0001844	Abnormal hallux morphology		Damage to the flexor hallucis longus (FHL) tendon. The FHL tendon is a long tendon that runs from the deep calf muscle down through the ankle to the big toe, enabling toe flexion and supporting foot mechanics.. MRI or ultrasound of the ankle/foot shows degenerative changes of the FHL tendon such as fluid around the tendon at the level of the ankle joint, intra-substance tendinous signal, tendon thickening, tendonitis, or tenosynovitis, or tendon rupture.
http://purl.obolibrary.org/obo/HP_6001401	Hallux pain	http://purl.obolibrary.org/obo/HP_0030841	Toe pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the big toe (hallux).
http://purl.obolibrary.org/obo/HP_6001402	Pain on the medial aspect of the foot	http://purl.obolibrary.org/obo/HP_0025238	Foot pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the side of the foot nearest to the big toe (hallux).
http://purl.obolibrary.org/obo/HP_6001403	Hallux sesamoid injury	http://purl.obolibrary.org/obo/HP_0001844	Abnormal hallux morphology		Damage affecting one or both of the two small, pea-shaped bones (sesamoids) embedded in the tendons beneath the first metatarsophalangeal joint of the big toe. Foot x-ray shows fracture, subluxation, or dislocation of the sesamoid of the hallux.
http://purl.obolibrary.org/obo/HP_6001404	Radial wrist pain	http://purl.obolibrary.org/obo/HP_0030836	Wrist pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the radial side of the wrist.
http://purl.obolibrary.org/obo/HP_6001405	Volar wrist pain	http://purl.obolibrary.org/obo/HP_0030836	Wrist pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the volar side of the wrist (i.e., to the palm side - front - of the wrist).
http://purl.obolibrary.org/obo/HP_6001406	Dorsal wrist pain	http://purl.obolibrary.org/obo/HP_0030836	Wrist pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the dorsal side (back) of the wrist.
http://purl.obolibrary.org/obo/HP_6001407	Peroneal tendon tenderness	http://purl.obolibrary.org/obo/HP_0025238	Foot pain		Pain elicited with palpation along the course of the peroneal tendons, located posterior to the lateral malleolus and extending distally toward the base of the fifth metatarsal.
http://purl.obolibrary.org/obo/HP_6001408	Peroneal tendon subluxation	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Dynamic ultrasound of the lateral ankle showing subluxation or dislocation of one or both of the peroneal tendons out of the peroneal groove.
http://purl.obolibrary.org/obo/HP_6001409	Peroneal tendon injury	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Ankle MRI or ultrasound showing edema or thickening of peroneal tendon(s), fluid within peroneal tendon sheath, or a partial or complete tear in one or both of the peroneal tendons.
http://purl.obolibrary.org/obo/HP_6001411	Flat palate	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		Reduced height of the palate. A flat palate is present with a palatal index angle below 30 degrees, a normal palate with an angle between 30 and 45 degrees, and a steep palate with an angle above 45 degrees.
http://purl.obolibrary.org/obo/HP_6001412	Elevated circulating C-terminal telopeptide cross-link of type1 collagen concentration	http://purl.obolibrary.org/obo/HP_0033386	Abnormal circulating collagen degradation product concentration		The concentration of C-terminal telopeptide cross-link of type1 collagen in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001413	Exacerbated by pulmonary vasodilator exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by treatment with a pulmonary vasodilator medication such as prostacyclin analogs, endothelin receptor antagonists, and phosphodiesterase-5 (PDE5) inhibitors.
http://purl.obolibrary.org/obo/HP_6001414	Mercury exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of exposure to mercury.
http://purl.obolibrary.org/obo/HP_6001415	Urinoma	http://purl.obolibrary.org/obo/HP_6000285	Retroperitoneal mass		Encapsulated collections of urine around the kidney in the retroperitoneum, most commonly in the perirenal space, as a consequence of renal tract leakage caused by urinary obstruction, trauma, or post-instrumentation.
http://purl.obolibrary.org/obo/HP_6001416	Umbilical discharge	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		Abnormal fluid draining from the umbilicus (from wounds, surgical sites, or fistulas).
http://purl.obolibrary.org/obo/HP_6001418	Abnormal fetal femur length	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		Femur length is measured between the outer border of one end of the the femoral diaphysis to the other outer border, excluding the epiphysis or other artifact. Abnormal femur length is defined as being more than two standard deviations away from the mean.
http://purl.obolibrary.org/obo/HP_6001419	Pain exacerbated by wrist ulnar deviation	http://purl.obolibrary.org/obo/HP_6001152	Pain exacerbated by wrist deviation		Pain worsens with wrist ulnar deviation (i.e., the pain is exacerbated if the hand is moved towards the side with the fifth finger).
http://purl.obolibrary.org/obo/HP_6001420	Pain exacerbated by wrist radial deviation	http://purl.obolibrary.org/obo/HP_6001152	Pain exacerbated by wrist deviation		Pain worsens with wrist radial deviation (i.e., the pain is exacerbated if the hand is moved towards the side with the thumb).
http://purl.obolibrary.org/obo/HP_6001421	Ulnar positive variance	http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology		A phenomenon whereby the distal ulna articular surface is more distal than the distal radius articular surface.
http://purl.obolibrary.org/obo/HP_6001422	Negative ulnar variance	http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology		Negative ulnar variance is a condition in which the ulna is relatively shorter than the radius at the carpus. AP wrist X-ray shows the distal ulna articular surface more proximal than the distal radius articular surface.
http://purl.obolibrary.org/obo/HP_6001423	Flexor carpi radialis tendonitis	http://purl.obolibrary.org/obo/HP_0025230	Tendonitis		Inflammation of the flexor carpi radialis (FCR) tendon, which traverses the carpus through a narrow fibro-osseous tunnel.
http://purl.obolibrary.org/obo/HP_6001424	Transillumination test shows high light transmission	http://purl.obolibrary.org/obo/HP_0025758	Characteristic of mass		A transillumination test involves shining light through an area of the body or a mass. This term refers to a transillumination test that shows especially high (positive) transillumination, which may be observed when a mass or swelling contains clear fluid rather than solid tissue or blood.
http://purl.obolibrary.org/obo/HP_6001425	Hyperleukocytosis	http://purl.obolibrary.org/obo/HP_0001974	Increased total leukocyte count		Hyperleukocytosis is commonly defined as a white blood cell (WBC) count of greater than 100,000 luekocytes per microliter.
http://purl.obolibrary.org/obo/HP_6001427	Valgus instability of the elbow	http://purl.obolibrary.org/obo/HP_6001426	Elbow instability		A type of elbow instability that arises through injuries to the medial collateral ligament (MCL), specifically the anterior bundle (AMCL). In the valgus stress test, the elbow is placed in 20 to 30 degrees of flexion with the forearm supinated and a valgus stress is applied. The test is positive when no firm end point is palpated, greater than 1 mm of medial joint opening is noted (fluoroscopically), or there is reproduction of the patient's pain.
http://purl.obolibrary.org/obo/HP_6001428	Varus instability of the elbow	http://purl.obolibrary.org/obo/HP_6001426	Elbow instability		A type of elbow insttability characterized by abnormal widening or gapping of the lateral (radial) side of the elbow joint when a varus stress is applied, due to insufficiency of the lateral collateral ligament complex.
http://purl.obolibrary.org/obo/HP_6001429	Limited foot eversion	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		Decreased foot eversion secondary to pain, weakness, or mechanical block.
http://purl.obolibrary.org/obo/HP_6001430	Limited foot inversion	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		Decreased foot inversion secondary to pain, weakness, or mechanical block.
http://purl.obolibrary.org/obo/HP_6001431	Positive synovial Tropheryma whipplei bacteria microscopy	http://purl.obolibrary.org/obo/HP_6000581	Positive synonvial fluid infectious agent test		Demonstration of Tropheryma whipplei bacteria in the synovial (joint) fluid by microscopic analysis.
http://purl.obolibrary.org/obo/HP_6001432	Positive calf squeeze test	http://purl.obolibrary.org/obo/HP_0011843	Abnormal musculoskeletal physiology		An abnormal result of the calf-squeeze test (also known as the Thompson test), which is considered a sign of Achilles tendon rupture. The test is positive (abnormal) if no plantar flexion of the foot occurs at calf squeezing.
http://purl.obolibrary.org/obo/HP_6001433	Achilles tendon tear	http://purl.obolibrary.org/obo/HP_0005109	Abnormal Achilles tendon morphology		A partial or complete break in the Achilles tendon (the tendon that connects the gastrocnemius and soleus to the calcaneus). This feature can be ascertained by magnetic resonance imaing (MRI) of the foot/ankle showing partial or complete tear of the achilles tendon.
http://purl.obolibrary.org/obo/CHEBI_132142	1,4-naphthoquinones	http://purl.obolibrary.org/obo/CHEBI_25481	naphthoquinone		A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring.
http://purl.obolibrary.org/obo/CHEBI_15756	hexadecanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A straight-chain, sixteen-carbon, saturated long-chain fatty acid.
http://purl.obolibrary.org/obo/CHEBI_15841	polypeptide	http://purl.obolibrary.org/obo/CHEBI_33839	macromolecule		A peptide containing ten or more amino acid residues.
http://purl.obolibrary.org/obo/CHEBI_15903	beta-D-glucose	http://purl.obolibrary.org/obo/CHEBI_4167	D-glucopyranose		<small>D</small>-Glucopyranose with β configuration at the anomeric centre.
http://purl.obolibrary.org/obo/CHEBI_16180	N-acylglycine	http://purl.obolibrary.org/obo/CHEBI_140325	secondary carboxamide		An <em>N</em>-acyl-amino acid in which amino acid specified is glycine.
http://purl.obolibrary.org/obo/CHEBI_16958	beta-alanine	http://purl.obolibrary.org/obo/CHEBI_33706	beta-amino acid		A naturally-occurring β-amino acid comprising propionic acid with the amino group in the 3-position.
http://purl.obolibrary.org/obo/CHEBI_17217	2-butenoic acid	http://purl.obolibrary.org/obo/CHEBI_22959	butenoic acid		A butenoic acid having the double bond at position C-2.
http://purl.obolibrary.org/obo/CHEBI_17579	beta-carotene	http://purl.obolibrary.org/obo/CHEBI_139120	carotenoid beta-end derivative		A cyclic carotene obtained by dimerisation of <i>all</i>-<i>trans</i>-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.
http://purl.obolibrary.org/obo/CHEBI_23849	diterpenoid	http://purl.obolibrary.org/obo/CHEBI_26873	terpenoid		Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
http://purl.obolibrary.org/obo/CHEBI_24129	furans	http://purl.obolibrary.org/obo/CHEBI_38104	oxacycle		Compounds containing at least one furan ring.
http://purl.obolibrary.org/obo/CHEBI_24628	imidazolidine-2,4-dione	http://purl.obolibrary.org/obo/CHEBI_55370	imidazolidinone		An imidazolidinone with oxo groups at position 2 and 4.
http://purl.obolibrary.org/obo/CHEBI_24654	hydroxy fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid carrying one or more hydroxy substituents.
http://purl.obolibrary.org/obo/CHEBI_25000	lactone	http://purl.obolibrary.org/obo/CHEBI_35701	ester		Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
http://purl.obolibrary.org/obo/CHEBI_25230	methionine derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of methionine  by a heteroatom. The definition normally excludes peptides containing methionine residues.
http://purl.obolibrary.org/obo/CHEBI_25512	neurotransmitter	http://purl.obolibrary.org/obo/CHEBI_33280	molecular messenger		An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.
http://purl.obolibrary.org/obo/CHEBI_25698	ether	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		An organooxygen compound with formula ROR, where R is not hydrogen.
http://purl.obolibrary.org/obo/CHEBI_26191	polyol	http://purl.obolibrary.org/obo/CHEBI_33822	organic hydroxy compound		A compound that contains two or more hydroxy groups.
http://purl.obolibrary.org/obo/CHEBI_26347	prostanoid	http://purl.obolibrary.org/obo/CHEBI_23899	icosanoid		The family of natural prostaglandins and prostaglandin-like compounds including prostacyclins and thromboxanes.
http://purl.obolibrary.org/obo/CHEBI_26455	pyrroles	http://purl.obolibrary.org/obo/CHEBI_68452	azole		An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton.
http://purl.obolibrary.org/obo/CHEBI_27024	toluenes	http://purl.obolibrary.org/obo/CHEBI_22712	benzenes		Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group.
http://purl.obolibrary.org/obo/CHEBI_27311	volatile oil component	http://purl.obolibrary.org/obo/CHEBI_76924	plant metabolite		Any plant metabolite that is found naturally as a component of a volatile oil.
http://purl.obolibrary.org/obo/CHEBI_28842	octadecanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A C<small><sub>18</sub></small> straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and  plastics.
http://purl.obolibrary.org/obo/CHEBI_28875	tetradecanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.
http://purl.obolibrary.org/obo/CHEBI_29256	thiol	http://purl.obolibrary.org/obo/CHEBI_33261	organosulfur compound		An organosulfur compound in which a thiol group, ‒SH, is attached to a carbon atom of any aliphatic or aromatic moiety.
http://purl.obolibrary.org/obo/CHEBI_32952	amine	http://purl.obolibrary.org/obo/CHEBI_50047	organic amino compound		A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.
http://purl.obolibrary.org/obo/CHEBI_33261	organosulfur compound	http://purl.obolibrary.org/obo/CHEBI_26835	sulfur molecular entity		An organosulfur compound is a compound containing at least one carbon-sulfur bond.
http://purl.obolibrary.org/obo/CHEBI_33567	catecholamine	http://purl.obolibrary.org/obo/CHEBI_64365	aralkylamino compound		4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.
http://purl.obolibrary.org/obo/CHEBI_33822	organic hydroxy compound	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		An organic compound having at least one hydroxy group attached to a carbon atom.
http://purl.obolibrary.org/obo/CHEBI_35341	steroid	http://purl.obolibrary.org/obo/CHEBI_51958	organic polycyclic compound		Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[<em>a</em>]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.
http://purl.obolibrary.org/obo/CHEBI_35469	antidepressant	http://purl.obolibrary.org/obo/CHEBI_35471	psychotropic drug		Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
http://purl.obolibrary.org/obo/CHEBI_36233	disaccharide	http://purl.obolibrary.org/obo/CHEBI_50699	oligosaccharide		A compound in which two monosaccharides are joined by a glycosidic bond.
http://purl.obolibrary.org/obo/CHEBI_38101	organonitrogen heterocyclic compound	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
http://purl.obolibrary.org/obo/CHEBI_38260	pyrrolidines	http://purl.obolibrary.org/obo/CHEBI_25693	organic heteromonocyclic compound		Any of a class of heterocyclic amines having a saturated five-membered ring.
http://purl.obolibrary.org/obo/CHEBI_50902	genotoxin	http://purl.obolibrary.org/obo/CHEBI_52209	aetiopathogenetic role		A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells.
http://purl.obolibrary.org/obo/CHEBI_50904	allergen	http://purl.obolibrary.org/obo/CHEBI_52209	aetiopathogenetic role		A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
http://purl.obolibrary.org/obo/CHEBI_546807	beta-D-Galp-(1->3)-D-GalpNAc	http://purl.obolibrary.org/obo/CHEBI_146500	D-Galp-(1->3)-D-GalpNAc		An amino disaccharide consisting of <small>D</small>-galactopyranose at the non-reducing end joined by a (1→3) glycosidic linkage to <em>N</em>-acetyl-<small>D</small>-galactopyranosamine.
http://purl.obolibrary.org/obo/CHEBI_5686	heterocyclic compound	http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound		A cyclic compound having as ring members atoms of at least two different elements.
http://purl.obolibrary.org/obo/CHEBI_59163	biomarker	http://purl.obolibrary.org/obo/CHEBI_47867	indicator		A substance used as an indicator  of a biological state.
http://purl.obolibrary.org/obo/CHEBI_67079	anti-inflammatory agent	http://purl.obolibrary.org/obo/CHEBI_33232	application		Any compound that has anti-inflammatory effects.
http://purl.obolibrary.org/obo/CHEBI_67200	provitamin A	http://purl.obolibrary.org/obo/CHEBI_50188	provitamin		A provitamin that can be converted into vitamin A by enzymes from animal tissues.
http://purl.obolibrary.org/obo/CHEBI_74223	pyrrolidin-2-ones	http://purl.obolibrary.org/obo/CHEBI_38275	pyrrolidinone		A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.
http://purl.obolibrary.org/obo/CHEBI_76956	Aspergillus metabolite	http://purl.obolibrary.org/obo/CHEBI_76946	fungal metabolite		Any fungal metabolite produced during a metabolic reaction in the mould, <em>Aspergillus </em>.
http://purl.obolibrary.org/obo/CHEBI_76967	human xenobiotic metabolite	http://purl.obolibrary.org/obo/CHEBI_77746	human metabolite		Any human metabolite produced by metabolism of a xenobiotic compound in humans.
http://purl.obolibrary.org/obo/CHEBI_83056	Daphnia magna metabolite	http://purl.obolibrary.org/obo/CHEBI_83057	Daphnia metabolite		A <em>Daphnia</em> metabolite produced by the species <em>Daphnia magna</em>.
http://purl.obolibrary.org/obo/CHEBI_84729	hydroxyindoles	http://purl.obolibrary.org/obo/CHEBI_24828	indoles		Any member of the class of  indoles carrying at least one hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_11596	2-hydroxyglutarate(2-)	http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion		A dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxylic acid groups of 2-hydroxyglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_132941	2-hydroxyglutarate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_15753	2-oxoadipic acid	http://purl.obolibrary.org/obo/CHEBI_36145	oxo dicarboxylic acid		An oxo dicarboxylic acid that is adipic acid substituted by an oxo group at position 2.
http://purl.obolibrary.org/obo/CHEBI_15904	long-chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		A fatty acid with a chain length ranging from C<small><sub>13</sub></small> to C<small><sub>22</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_16810	2-oxoglutarate(2-)	http://purl.obolibrary.org/obo/CHEBI_36147	oxo dicarboxylate		An oxo dicarboxylate obtained by deprotonation of both carboxy groups of 2-oxoglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_17084	2-hydroxyglutaric acid	http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid		A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen α- to a carboxylic acid group is substituted by a hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_24684	hydroxybutyric acid	http://purl.obolibrary.org/obo/CHEBI_24654	hydroxy fatty acid		Any compound comprising a butyric acid core carrying at least one hydroxy substituent.
http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion	http://purl.obolibrary.org/obo/CHEBI_38716	carboxylic acid dianion		A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_30921	glutarate(2-)	http://purl.obolibrary.org/obo/CHEBI_24329	glutarate		A dicarboxylic acid dianion obtained by deprotonation of both the carboxy groups of glutaric acid.
http://purl.obolibrary.org/obo/CHEBI_32876	tertiary amine	http://purl.obolibrary.org/obo/CHEBI_50996	tertiary amino compound		A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.
http://purl.obolibrary.org/obo/CHEBI_33707	gamma-amino acid	http://purl.obolibrary.org/obo/CHEBI_83820	non-proteinogenic amino acid		A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position γ to the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_35179	2-oxo monocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_35902	oxo monocarboxylic acid anion		An oxo monocarboxylic acid anion in which the oxo group is located at the 2-position.
http://purl.obolibrary.org/obo/CHEBI_36149	2-hydroxyglutarate(1-)	http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion		A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of 2-hydroxyglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_36258	but-2-enoate	http://purl.obolibrary.org/obo/CHEBI_36029	butenoate		The conjugate base of but-2-enoic acid.
http://purl.obolibrary.org/obo/CHEBI_47868	photosensitizing agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
http://purl.obolibrary.org/obo/CHEBI_48944	isobutyrate	http://purl.obolibrary.org/obo/CHEBI_78115	fatty acid anion 4:0		A branched, short-chain, saturated fatty acid anion; the conjugate base of isobutyric acid, formed by deprotonation of the carboxylic acid group.
http://purl.obolibrary.org/obo/CHEBI_50263	2-hydroxydicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position α to the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_64049	food acidity regulator	http://purl.obolibrary.org/obo/CHEBI_64047	food additive		A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents.
http://purl.obolibrary.org/obo/CHEBI_74783	astringent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.
http://purl.obolibrary.org/obo/CHEBI_131444	guanidinoacetate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion that is the conjugate base of guanidinoacetic acid, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_131565	steroid aldehyde	http://purl.obolibrary.org/obo/CHEBI_17478	aldehyde		Any steroid substituted by a formyl group.
http://purl.obolibrary.org/obo/CHEBI_131619	C27-steroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		A steroid compound with a structure based on a 27-carbon (cholestane) skeleton.
http://purl.obolibrary.org/obo/CHEBI_131621	C19-steroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		A steroid compound with a structure based on a 19-carbon (androstane) skeleton.
http://purl.obolibrary.org/obo/CHEBI_131702	stigmastane derivative	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		Any steroid (or derivative) based on a stigmastane skeleton.
http://purl.obolibrary.org/obo/CHEBI_131703	stigmastane sterol	http://purl.obolibrary.org/obo/CHEBI_15889	sterol		Any sterol based on a stigmastane skeleton.
http://purl.obolibrary.org/obo/CHEBI_131927	dicarboxylic acids and O-substituted derivatives	http://purl.obolibrary.org/obo/CHEBI_36586	carbonyl compound		A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens.
http://purl.obolibrary.org/obo/CHEBI_132153	hyaluronate	http://purl.obolibrary.org/obo/CHEBI_63551	carbohydrate acid derivative anion		A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_132177	2-hydroxy-3-methyl-2-butenoic acid	http://purl.obolibrary.org/obo/CHEBI_79020	alpha,beta-unsaturated monocarboxylic acid		An α,β-unsaturated monocarboxylic acid that is 3-methylbut-2-enoic acid in which the hydrogen at position 2 has been replaced by a hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_132362	citrate(4-)	http://purl.obolibrary.org/obo/CHEBI_133748	citrate anion		A citrate anion obtained by deprotonation of the three carboxy groups as well as the hydroxy group of citric acid.
http://purl.obolibrary.org/obo/CHEBI_132542	fatty acid 22:4	http://purl.obolibrary.org/obo/CHEBI_26208	polyunsaturated fatty acid		Any polyunsaturated fatty acid containing 22 carbons and 4 double bonds.
http://purl.obolibrary.org/obo/CHEBI_132938	ethylmalonate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of ethylmalonic acid.
http://purl.obolibrary.org/obo/CHEBI_133251	3-hydroxydicarboxylate(2-)	http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion		A dicarboxylic acid dianion that results from the removal of a proton from both of the carboxylic acid groups of any 3-hydroxydicarboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_133748	citrate anion	http://purl.obolibrary.org/obo/CHEBI_35753	tricarboxylic acid anion		A tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid.
http://purl.obolibrary.org/obo/CHEBI_13643	glycol	http://purl.obolibrary.org/obo/CHEBI_23824	diol		A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent.
http://purl.obolibrary.org/obo/CHEBI_15361	pyruvate	http://purl.obolibrary.org/obo/CHEBI_35179	2-oxo monocarboxylic acid anion		A 2-oxo monocarboxylic acid anion that is the conjugate base of pyruvic acid, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_15366	acetic acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		A simple monocarboxylic acid containing two carbons.
http://purl.obolibrary.org/obo/CHEBI_15889	sterol	http://purl.obolibrary.org/obo/CHEBI_36834	3-hydroxy steroid		Any 3-hydroxy steroid whose skeleton is closely related to cholestan-3-ol (additional carbon atoms may be present in the side chain).
http://purl.obolibrary.org/obo/CHEBI_15891	taurine	http://purl.obolibrary.org/obo/CHEBI_37793	amino sulfonic acid		An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from  methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.
http://purl.obolibrary.org/obo/CHEBI_15999	4-hydroxyphenylpyruvic acid	http://purl.obolibrary.org/obo/CHEBI_35910	2-oxo monocarboxylic acid		A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
http://purl.obolibrary.org/obo/CHEBI_16094	thiosulfate(2-)	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.
http://purl.obolibrary.org/obo/CHEBI_16336	hyaluronic acid	http://purl.obolibrary.org/obo/CHEBI_72813	exopolysaccharide		A mucopolysaccharide composed of <em>N</em>-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.
http://purl.obolibrary.org/obo/CHEBI_16344	guanidinoacetic acid	http://purl.obolibrary.org/obo/CHEBI_24439	guanidinoacetic acids		The <em>N</em>-amidino derivative of glycine.
http://purl.obolibrary.org/obo/CHEBI_16449	alanine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that consists of propionic acid bearing an amino substituent at position 2.
http://purl.obolibrary.org/obo/CHEBI_16526	carbon dioxide	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		A one-carbon compound with formula CO<small><sub>2</sub></small> in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food.
http://purl.obolibrary.org/obo/CHEBI_16643	L-methionine	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		The <small>L</small>-enantiomer of methionine.
http://purl.obolibrary.org/obo/CHEBI_16765	tryptamine	http://purl.obolibrary.org/obo/CHEBI_64365	aralkylamino compound		An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.
http://purl.obolibrary.org/obo/CHEBI_16947	citrate(3-)	http://purl.obolibrary.org/obo/CHEBI_27092	tricarboxylic acid trianion		A tricarboxylic acid trianion, obtained by deprotonation of the three carboxy groups of citric acid.
http://purl.obolibrary.org/obo/CHEBI_17002	cholesteryl ester	http://purl.obolibrary.org/obo/CHEBI_35915	sterol ester		A sterol ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of cholesterol.
http://purl.obolibrary.org/obo/CHEBI_17203	L-proline	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		Pyrrolidine in which the <em>pro</em>-<i>S</i> hydrogen at position 2 is substituted by a carboxylic acid group. <small>L</small>-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group α to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles.
http://purl.obolibrary.org/obo/CHEBI_17347	testosterone	http://purl.obolibrary.org/obo/CHEBI_47909	3-oxo-Delta(4) steroid		An androstanoid having 17β-hydroxy and 3-oxo groups, together with unsaturation at C-4‒C-5..
http://purl.obolibrary.org/obo/CHEBI_17561	L-cysteine	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		An optically active form of cysteine having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_17748	thymidine	http://purl.obolibrary.org/obo/CHEBI_19255	pyrimidine 2'-deoxyribonucleoside		A pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase.
http://purl.obolibrary.org/obo/CHEBI_17821	thymine	http://purl.obolibrary.org/obo/CHEBI_38337	pyrimidone		A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group.
http://purl.obolibrary.org/obo/CHEBI_17855	triglyceride	http://purl.obolibrary.org/obo/CHEBI_76579	triradylglycerol		Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.
http://purl.obolibrary.org/obo/CHEBI_17996	chloride	http://purl.obolibrary.org/obo/CHEBI_33432	monoatomic chlorine		A halide anion formed when chlorine picks up an electron to form an an anion.
http://purl.obolibrary.org/obo/CHEBI_18059	lipid	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
http://purl.obolibrary.org/obo/CHEBI_18287	L-fucose	http://purl.obolibrary.org/obo/CHEBI_33984	fucose		Any form of fucose having <small>L</small> configuration.
http://purl.obolibrary.org/obo/CHEBI_18310	alkane	http://purl.obolibrary.org/obo/CHEBI_33653	aliphatic compound		An acyclic branched or unbranched hydrocarbon having the general formula C<small><sub><em>n</em></sub></small>H<small><sub>2<em>n</em>+2</sub></small>, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_21545	N-acetyl-L-amino acid	http://purl.obolibrary.org/obo/CHEBI_21575	N-acetyl-amino acid		An <small>L</small>-amino acid having an <em>N</em>-acetyl substituent.
http://purl.obolibrary.org/obo/CHEBI_22480	amino disaccharide	http://purl.obolibrary.org/obo/CHEBI_22483	amino oligosaccharide		A disaccharide derivative that is a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.
http://purl.obolibrary.org/obo/CHEBI_23357	cofactor	http://purl.obolibrary.org/obo/CHEBI_52206	biochemical role		An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
http://purl.obolibrary.org/obo/CHEBI_23628	deoxyhexose	http://purl.obolibrary.org/obo/CHEBI_33917	aldohexose		Any C<small><sub>6</sub></small> deoxy sugar having at least one hydroxy group replaced by hydrogen.
http://purl.obolibrary.org/obo/CHEBI_23824	diol	http://purl.obolibrary.org/obo/CHEBI_26191	polyol		A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
http://purl.obolibrary.org/obo/CHEBI_24533	heterodetic cyclic peptide	http://purl.obolibrary.org/obo/CHEBI_23449	cyclic peptide		A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
http://purl.obolibrary.org/obo/CHEBI_24833	oxoacid	http://purl.obolibrary.org/obo/CHEBI_24651	hydroxides		A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
http://purl.obolibrary.org/obo/CHEBI_25367	molecule	http://purl.obolibrary.org/obo/CHEBI_36357	polyatomic entity		Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
http://purl.obolibrary.org/obo/CHEBI_25413	monounsaturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_27208	unsaturated fatty acid		Any fatty acid with one double or triple bond in the fatty acid chain and singly bonded carbon atoms in the rest of the chain. MUFAs have positive effects on the cardiovascular system, and in diabetes treatment.
http://purl.obolibrary.org/obo/CHEBI_25629	octadecanoate	http://purl.obolibrary.org/obo/CHEBI_83955	2-saturated fatty acid anion		A fatty acid anion 18:0 that is the conjugate base of octadecanoic acid (stearic acid). Stearates have a variety of uses in the pharmaceutical industry.
http://purl.obolibrary.org/obo/CHEBI_25646	octanoate	http://purl.obolibrary.org/obo/CHEBI_58954	straight-chain saturated fatty acid anion		A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.
http://purl.obolibrary.org/obo/CHEBI_25696	organic anion	http://purl.obolibrary.org/obo/CHEBI_25699	organic ion		Any organic ion with a net negative charge.
http://purl.obolibrary.org/obo/CHEBI_2571	aliphatic alcohol	http://purl.obolibrary.org/obo/CHEBI_30879	alcohol		An  alcohol derived from an aliphatic compound.
http://purl.obolibrary.org/obo/CHEBI_2580	unsaturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		Any fatty acid anion containing at least one C-C unsaturated bond; formed by deprotonation of the carboxylic acid moiety.
http://purl.obolibrary.org/obo/CHEBI_26125	phytosterols	http://purl.obolibrary.org/obo/CHEBI_26124	phytosteroid		Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.
http://purl.obolibrary.org/obo/CHEBI_26155	plant growth regulator	http://purl.obolibrary.org/obo/CHEBI_39317	growth regulator		A chemical, natural or artificial, that can affect the rate of growth of a plant.
http://purl.obolibrary.org/obo/CHEBI_26432	pyrimidine nucleobase	http://purl.obolibrary.org/obo/CHEBI_39447	pyrimidines		A nucleobase whose skeleton is derived from pyrimidine.
http://purl.obolibrary.org/obo/CHEBI_26607	saturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess.
http://purl.obolibrary.org/obo/CHEBI_27026	toxin	http://purl.obolibrary.org/obo/CHEBI_25212	metabolite		Poisonous substance produced by a biological organism such as a microbe, animal or plant.
http://purl.obolibrary.org/obo/CHEBI_27283	very long-chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		A fatty acid which has a chain length greater than C<small><sub>22</sub></small>. Very long-chain fatty acids which have a chain length greater than C27 are also known as ultra-long-chain fatty acids.
http://purl.obolibrary.org/obo/CHEBI_27369	zwitterion	http://purl.obolibrary.org/obo/CHEBI_51151	dipolar compound		A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).
http://purl.obolibrary.org/obo/CHEBI_27780	detergent	http://purl.obolibrary.org/obo/CHEBI_33232	application		A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions.
http://purl.obolibrary.org/obo/CHEBI_28484	isovaleric acid	http://purl.obolibrary.org/obo/CHEBI_38653	methylbutyric acid		A C<small><sub>5</sub></small>, branched-chain saturated fatty acid.
http://purl.obolibrary.org/obo/CHEBI_28837	octanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.
http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_35406	oxoanion		The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated.
http://purl.obolibrary.org/obo/CHEBI_29805	glycolate	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		A hydroxy monocarboxylic acid anion that is acetate where the methyl group has been hydroxylated.
http://purl.obolibrary.org/obo/CHEBI_29985	L-glutamate(1-)	http://purl.obolibrary.org/obo/CHEBI_14321	glutamate(1-)		An α-amino-acid anion that is the conjugate base of <small>L</small>-glutamic acid, having anionic carboxy groups and a cationic amino group
http://purl.obolibrary.org/obo/CHEBI_30089	acetate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid.
http://purl.obolibrary.org/obo/CHEBI_30363	isobutane	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		An alkane that is propane substituted by a methyl group at position 2.
http://purl.obolibrary.org/obo/CHEBI_30413	heme	http://purl.obolibrary.org/obo/CHEBI_33909	metallotetrapyrrole		A heme is any tetrapyrrolic chelate of iron.
http://purl.obolibrary.org/obo/CHEBI_30623	oxalate(2-)	http://purl.obolibrary.org/obo/CHEBI_132952	oxalate		A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of oxalic acid.
http://purl.obolibrary.org/obo/CHEBI_30745	phenylacetic acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.
http://purl.obolibrary.org/obo/CHEBI_30776	hexanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A C<small><sub>6</sub></small>, straight-chain saturated fatty acid.
http://purl.obolibrary.org/obo/CHEBI_30813	decanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A C<small><sub>10</sub></small>, straight-chain saturated fatty acid.
http://purl.obolibrary.org/obo/CHEBI_33247	organic group	http://purl.obolibrary.org/obo/CHEBI_24433	group		Any substituent group or skeleton containing carbon.
http://purl.obolibrary.org/obo/CHEBI_33554	organosulfonate oxoanion	http://purl.obolibrary.org/obo/CHEBI_25696	organic anion		An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid.
http://purl.obolibrary.org/obo/CHEBI_33708	amino-acid residue	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.
http://purl.obolibrary.org/obo/CHEBI_33752	hexonic acid	http://purl.obolibrary.org/obo/CHEBI_22301	aldonic acid		Any aldonic acid formed by oxidising the aldehyde group of an aldohexose to a carboxylic acid group.
http://purl.obolibrary.org/obo/CHEBI_33856	aromatic amino acid	http://purl.obolibrary.org/obo/CHEBI_33709	amino acid		An amino acid whose structure includes an aromatic ring.
http://purl.obolibrary.org/obo/CHEBI_33893	reagent	http://purl.obolibrary.org/obo/CHEBI_33232	application		A substance used in a chemical reaction to detect, measure, examine, or produce other substances.
http://purl.obolibrary.org/obo/CHEBI_33916	aldopentose	http://purl.obolibrary.org/obo/CHEBI_15693	aldose		A pentose with a (potential) aldehyde group at one end.
http://purl.obolibrary.org/obo/CHEBI_35191	triterpene	http://purl.obolibrary.org/obo/CHEBI_35186	terpene		A C<small><sub>30</sub></small> terpene.
http://purl.obolibrary.org/obo/CHEBI_35195	surfactant	http://purl.obolibrary.org/obo/CHEBI_63046	emulsifier		A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.
http://purl.obolibrary.org/obo/CHEBI_35222	inhibitor	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A substance that diminishes the rate of a chemical reaction.
http://purl.obolibrary.org/obo/CHEBI_35223	catalyst	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.
http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_27369	zwitterion		The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group.
http://purl.obolibrary.org/obo/CHEBI_35284	ammonium betaine	http://purl.obolibrary.org/obo/CHEBI_35281	onium betaine		Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
http://purl.obolibrary.org/obo/CHEBI_35343	17beta-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_36838	17-hydroxy steroid		A 17-hydroxy steroid in which the hydroxy group at position 17 has a β-configuration.
http://purl.obolibrary.org/obo/CHEBI_35526	hypoglycemic agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug which lowers the blood glucose level.
http://purl.obolibrary.org/obo/CHEBI_35617	flavouring agent	http://purl.obolibrary.org/obo/CHEBI_64047	food additive		A food additive that is used to added improve the taste or odour of a food.
http://purl.obolibrary.org/obo/CHEBI_35744	carbocyclic fatty acid	http://purl.obolibrary.org/obo/CHEBI_59238	cyclic fatty acid		Any fatty acid containing a ring composed of carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_35753	tricarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		Any anion of a tricarboxylic acid  formed by deprotonation of at least one carboxy group.
http://purl.obolibrary.org/obo/CHEBI_35868	hydroxy monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_24669	hydroxy carboxylic acid		Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent.
http://purl.obolibrary.org/obo/CHEBI_35915	sterol ester	http://purl.obolibrary.org/obo/CHEBI_47880	steroid ester		A steroid ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of a sterol.
http://purl.obolibrary.org/obo/CHEBI_35969	3-hydroxy monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_61355	3-hydroxy carboxylic acid		A hydroxy monocarboxylic acid that has a hydroxy group β to the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_35972	dihydroxy monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35868	hydroxy monocarboxylic acid		Any  hydroxy monocarboxylic acid carrying at least two hydroxy groups.
http://purl.obolibrary.org/obo/CHEBI_36141	quinone	http://purl.obolibrary.org/obo/CHEBI_3992	cyclic ketone		Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of ‒CH= groups into ‒C(=O)‒ groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).
http://purl.obolibrary.org/obo/CHEBI_36587	organic oxo compound	http://purl.obolibrary.org/obo/CHEBI_72695	organic molecule		Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
http://purl.obolibrary.org/obo/CHEBI_36836	3beta-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_35681	secondary alcohol		A 3-hydroxy steroid in which the 3-hydroxy substituent is in the  β-position.
http://purl.obolibrary.org/obo/CHEBI_37127	3-methylbut-2-enoic acid	http://purl.obolibrary.org/obo/CHEBI_62499	methyl-branched fatty acid		A methyl-branched fatty acid that is but-2-enoic acid bearing a methyl substituent at position 3.
http://purl.obolibrary.org/obo/CHEBI_37793	amino sulfonic acid	http://purl.obolibrary.org/obo/CHEBI_33551	organosulfonic acid		An organosulfonic acid containing one or more amino groups.
http://purl.obolibrary.org/obo/CHEBI_38161	chelator	http://purl.obolibrary.org/obo/CHEBI_52214	ligand		A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.
http://purl.obolibrary.org/obo/CHEBI_38234	DNA polymerase inhibitor	http://purl.obolibrary.org/obo/CHEBI_76815	EC 2.7.7.* (nucleotidyltransferase) inhibitor		Any inhibitor of a DNA polymerase.
http://purl.obolibrary.org/obo/CHEBI_39024	clathrate compound	http://purl.obolibrary.org/obo/CHEBI_39022	inclusion compound		Inclusion compound in which the guest molecule is in a cage formed by the host molecule or by a lattice of host molecules.
http://purl.obolibrary.org/obo/CHEBI_39417	branched-chain saturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_35819	branched-chain fatty acid		Any saturated fatty acid with a carbon side-chain or isopropyl termination.
http://purl.obolibrary.org/obo/CHEBI_46662	mineral	http://purl.obolibrary.org/obo/CHEBI_59999	chemical substance		In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals').
http://purl.obolibrary.org/obo/CHEBI_47788	3-oxo steroid	http://purl.obolibrary.org/obo/CHEBI_3992	cyclic ketone		Any oxo steroid where an oxo substituent is located at position 3.
http://purl.obolibrary.org/obo/CHEBI_47891	steroid acid	http://purl.obolibrary.org/obo/CHEBI_64709	organic acid		Any steroid substituted by at least one carboxy group.
http://purl.obolibrary.org/obo/CHEBI_48356	protic solvent	http://purl.obolibrary.org/obo/CHEBI_48354	polar solvent		A polar solvent that is capable of acting as a hydron (proton) donor.
http://purl.obolibrary.org/obo/CHEBI_48578	radical scavenger	http://purl.obolibrary.org/obo/CHEBI_22586	antioxidant		A role played by a substance that can react readily with, and thereby eliminate, radicals.
http://purl.obolibrary.org/obo/CHEBI_48705	agonist	http://purl.obolibrary.org/obo/CHEBI_52210	pharmacological role		Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
http://purl.obolibrary.org/obo/CHEBI_48927	N-acyl-L-alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_21644	N-acyl-L-amino acid		Any <small>L</small>-α-amino acid carrying an <em>N</em>-acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_50160	steroid acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		Any anion formed by loss of a proton from a steroid acid.
http://purl.obolibrary.org/obo/CHEBI_50177	dermatologic drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug used to treat or prevent skin disorders or for the routine care of skin.
http://purl.obolibrary.org/obo/CHEBI_50266	prodrug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
http://purl.obolibrary.org/obo/CHEBI_50402	androstanoid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		Any steroid based on an  androstane skeleton and its derivatives.
http://purl.obolibrary.org/obo/CHEBI_50503	laxative	http://purl.obolibrary.org/obo/CHEBI_23888	drug		An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic.
http://purl.obolibrary.org/obo/CHEBI_50733	nutraceutical	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
http://purl.obolibrary.org/obo/CHEBI_50857	anti-allergic agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug used to treat allergic reactions.
http://purl.obolibrary.org/obo/CHEBI_52206	biochemical role	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A biological role played by the molecular entity or part thereof within a biochemical context.
http://purl.obolibrary.org/obo/CHEBI_52217	pharmaceutical	http://purl.obolibrary.org/obo/CHEBI_33232	application		Any substance introduced into a living organism with therapeutic or diagnostic purpose.
http://purl.obolibrary.org/obo/CHEBI_52290	mitogen	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A chemical substance that encourages a cell to commence cell division, triggering mitosis.
http://purl.obolibrary.org/obo/CHEBI_52424	EC 3.2.1.* (glycosidase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76761	EC 3.2.* (glycosylase) inhibitor		An EC 3.2.* (glycosylase) inhibitor that interferes with the action of any glycosidase (i.e. enzymes hydrolysing <em>O</em>- and <em>S</em>-glycosyl compounds, EC 3.2.1.*).
http://purl.obolibrary.org/obo/CHEBI_52987	L-asparagine derivative	http://purl.obolibrary.org/obo/CHEBI_83811	proteinogenic amino acid derivative		A proteinogenic amino acid derivative resulting from reaction of <small>L</small>-asparagine at the amino group, the carboxy group, or the carboxamide, or from the replacement of any hydrogen of <small>L</small>-asparagine by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_53291	2-halophenol	http://purl.obolibrary.org/obo/CHEBI_38856	halophenol		A halophenol in which the halogen atom is bonded to the carbon atom adjacent to the C‒OH group.
http://purl.obolibrary.org/obo/CHEBI_53339	olefinic fatty acid	http://purl.obolibrary.org/obo/CHEBI_78840	olefinic compound		Any fatty acid containing at least one C=C double bond.
http://purl.obolibrary.org/obo/CHEBI_57670	N-acylglycinate	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A carboxylic acid anion obtained by deprotonation of the carboxy group of any <em>N</em>-acylglycine.
http://purl.obolibrary.org/obo/CHEBI_58123	(2S)-2-hydroxy monocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		A hydroxy monocarboxylic acid anion where the hydroxy group is placed at position 2 (α to the carboxy group) and has (<i>S</i>)-stereochemistry; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		Any fatty acid anion in which there is no C‒C unsaturation.
http://purl.obolibrary.org/obo/CHEBI_59132	antigen	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).
http://purl.obolibrary.org/obo/CHEBI_59326	prostaglandin carboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_62943	prostanoid anion		A prostanoid anion obtained by deprotonation of the carboxy group of any prostaglandin.
http://purl.obolibrary.org/obo/CHEBI_59412	amino tetrasaccharide	http://purl.obolibrary.org/obo/CHEBI_22483	amino oligosaccharide		A tetrasaccharide derivative having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.
http://purl.obolibrary.org/obo/CHEBI_59644	oxo fatty acid	http://purl.obolibrary.org/obo/CHEBI_25754	oxo carboxylic acid		Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group.
http://purl.obolibrary.org/obo/CHEBI_59845	3-hydroxy fatty acid	http://purl.obolibrary.org/obo/CHEBI_35969	3-hydroxy monocarboxylic acid		Any fatty acid with a hydroxy functional group in the β- or 3-position. β-Hydroxy fatty acids accumulate during cardiac hypoxia, and can also be used as chemical markers of bacterial endotoxins.
http://purl.obolibrary.org/obo/CHEBI_59874	N-acyl-L-alpha-amino acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A carboxylic acid anion that is the conjugate base of an <em>N</em>-acyl-<small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group.
http://purl.obolibrary.org/obo/CHEBI_60004	mixture	http://purl.obolibrary.org/obo/CHEBI_59999	chemical substance		A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.
http://purl.obolibrary.org/obo/CHEBI_60164	ionic polymer	http://purl.obolibrary.org/obo/CHEBI_60027	polymer		An ionic polymer is a polymer, composed of ionic macromolecules.
http://purl.obolibrary.org/obo/CHEBI_60311	thyroid hormone	http://purl.obolibrary.org/obo/CHEBI_24621	hormone		Any hormone produced by the thyroid gland
http://purl.obolibrary.org/obo/CHEBI_60334	peptide anion	http://purl.obolibrary.org/obo/CHEBI_25696	organic anion		An anion formed by deprotonation of at least one peptide carboxy group.
http://purl.obolibrary.org/obo/CHEBI_60926	amino monosaccharide	http://purl.obolibrary.org/obo/CHEBI_28963	amino sugar		Any  amino sugar that is a monosaccharide in which one alcoholic hydroxy group is replaced by an amino group.
http://purl.obolibrary.org/obo/CHEBI_61120	nucleobase-containing molecular entity	http://purl.obolibrary.org/obo/CHEBI_33833	heteroarene		Any compound that has a nucleobase as a part.
http://purl.obolibrary.org/obo/CHEBI_61205	docosatetraenoic acid	http://purl.obolibrary.org/obo/CHEBI_59202	straight-chain fatty acid		Any straight-chain, C<small><sub>22</sub></small> fatty acid having four C=C double bonds.
http://purl.obolibrary.org/obo/CHEBI_61355	3-hydroxy carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_24669	hydroxy carboxylic acid		Any hydroxy carboxylic acid which contains a hydroxy group located β- to the carboxylic acid group.
http://purl.obolibrary.org/obo/CHEBI_61469	polyanionic polymer	http://purl.obolibrary.org/obo/CHEBI_60164	ionic polymer		A polymer, composed of polyanion macromolecules.
http://purl.obolibrary.org/obo/CHEBI_61697	fatty acid derivative	http://purl.obolibrary.org/obo/CHEBI_18059	lipid		Any organic molecular entity derived from a fatty acid.
http://purl.obolibrary.org/obo/CHEBI_62488	signalling molecule	http://purl.obolibrary.org/obo/CHEBI_33280	molecular messenger		A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell.
http://purl.obolibrary.org/obo/CHEBI_62643	anionic phospholipid	http://purl.obolibrary.org/obo/CHEBI_58945	organophosphate oxoanion		Any organophosphate oxoanion that is a negatively charged phospholipid, e.g. phosphatidylserine(1−), phosphatidate(2−), phosphatidylglycerol(1−).
http://purl.obolibrary.org/obo/CHEBI_62937	icosanoid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		The carboxylic acid anion that is the conjugate base of an icosanoid, formed when the carboxy group is deprotonated.
http://purl.obolibrary.org/obo/CHEBI_63353	disaccharide derivative	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		A carbohydrate derivative that is formally obtained from a disaccharide.
http://purl.obolibrary.org/obo/CHEBI_63436	carbohydrate acid derivative	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		A carbohydrate derivative that is formally obtained from a carbohydrate acid.
http://purl.obolibrary.org/obo/CHEBI_63473	aromatic amino-acid anion	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		An aromatic amino acid whose α-carboxylic acid group is ionized (non-protonated).
http://purl.obolibrary.org/obo/CHEBI_63551	carbohydrate acid derivative anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative.
http://purl.obolibrary.org/obo/CHEBI_63567	tetrasaccharide derivative	http://purl.obolibrary.org/obo/CHEBI_63563	oligosaccharide derivative		An oligosaccharide derivative that is formally obtained from a tetrasaccharide.
http://purl.obolibrary.org/obo/CHEBI_63571	trisaccharide derivative	http://purl.obolibrary.org/obo/CHEBI_63563	oligosaccharide derivative		An oligosaccharide derivative that is formally obtained from a trisaccharide.
http://purl.obolibrary.org/obo/CHEBI_64571	NMDA receptor agonist	http://purl.obolibrary.org/obo/CHEBI_50103	excitatory amino acid agonist		An excitatory amino acid agonist which binds to NMDA receptors and triggers a response.
http://purl.obolibrary.org/obo/CHEBI_64775	organic anionic group	http://purl.obolibrary.org/obo/CHEBI_64767	anionic group		An anionic group that contains carbon.
http://purl.obolibrary.org/obo/CHEBI_64909	poison	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
http://purl.obolibrary.org/obo/CHEBI_6495	lipoprotein	http://purl.obolibrary.org/obo/CHEBI_33837	conjugated protein		A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
http://purl.obolibrary.org/obo/CHEBI_65212	polysaccharide derivative	http://purl.obolibrary.org/obo/CHEBI_167559	glycan		A carbohydrate derivative that is any derivative of a polysaccharide.
http://purl.obolibrary.org/obo/CHEBI_65255	food preservative	http://purl.obolibrary.org/obo/CHEBI_64047	food additive		Substances which are added to food in order to prevent decomposition caused by  microbial growth or by undesirable chemical changes.
http://purl.obolibrary.org/obo/CHEBI_65296	primary ammonium ion	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_741548	ethylmalonic acid	http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid		A dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group.
http://purl.obolibrary.org/obo/CHEBI_74222	gamma-lactam	http://purl.obolibrary.org/obo/CHEBI_24995	lactam		A lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon.
http://purl.obolibrary.org/obo/CHEBI_75768	mammalian metabolite	http://purl.obolibrary.org/obo/CHEBI_75767	animal metabolite		Any animal metabolite produced during a metabolic reaction in mammals.
http://purl.obolibrary.org/obo/CHEBI_75769	B vitamin	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B<small><sub>1</sub></small>, B<small><sub>2</sub></small>, B<small><sub>3</sub></small>, B<small><sub>5</sub></small>, B<small><sub>6</sub></small>, B<small><sub>7</sub></small>, B<small><sub>9</sub></small>, and B<small><sub>12</sub></small> (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such).
http://purl.obolibrary.org/obo/CHEBI_76567	polyunsaturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_2580	unsaturated fatty acid anion		Any unsaturated fatty acid anion containing more than one C-C unsaturated bond.  Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78608	alpha-amino-acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid-zwitterion obtained by transfer of a proton from the carboxy to the amino group of any α-amino acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78954	(omega-1)-hydroxy fatty acid	http://purl.obolibrary.org/obo/CHEBI_35681	secondary alcohol		A hydroxy fatty acid that is a straight-chain fatty acid in which one of the hydrogens attached to the carbon adjacent to the terminal methyl group (i.e. at the (ω−1) position) is replaced by a hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_82680	monounsaturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_2580	unsaturated fatty acid anion		Any unsaturated fatty acid anion with one double or triple bond in the fatty acid chain.
http://purl.obolibrary.org/obo/CHEBI_83039	crustacean metabolite	http://purl.obolibrary.org/obo/CHEBI_75767	animal metabolite		An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill.
http://purl.obolibrary.org/obo/CHEBI_83824	L-cysteine derivative	http://purl.obolibrary.org/obo/CHEBI_23509	cysteine derivative		A proteinogenic amino acid derivative resulting from the formal reaction of <small>L</small>-cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of <small>L</small>-cysteine by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_83978	L-aspartic acid derivative	http://purl.obolibrary.org/obo/CHEBI_83811	proteinogenic amino acid derivative		A proteinogenic amino acid derivative resulting from reaction of <small>L</small>-aspartic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of <small>L</small>-aspartic acid by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_84087	human urinary metabolite	http://purl.obolibrary.org/obo/CHEBI_77746	human metabolite		Any metabolite (endogenous or exogenous) found in human urine samples.
http://purl.obolibrary.org/obo/CHEBI_84497	(omega-1)-hydroxy fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_59835	hydroxy fatty acid anion		A hydroxy fatty acid anion obtained by deprotonation of the carboxy group of any (ω−1)-hydroxy fatty acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_86264	rat metabolite	http://purl.obolibrary.org/obo/CHEBI_75768	mammalian metabolite		Any mammalian metabolite produced during a metabolic reaction in rat (<em>Rattus norvegicus</em>).
http://purl.obolibrary.org/obo/CHEBI_86327	antifungal drug	http://purl.obolibrary.org/obo/CHEBI_35718	antifungal agent		Any antifungal agent used to prevent or treat fungal infections in humans or animals.
http://purl.obolibrary.org/obo/CHEBI_87656	hexanoate ester	http://purl.obolibrary.org/obo/CHEBI_35748	fatty acid ester		Any fatty acid ester where the carboxylic acid component is hexanoic (also known as caproic) acid.
http://purl.obolibrary.org/obo/CHEBI_20106	vanillylmandelic acid	http://purl.obolibrary.org/obo/CHEBI_35618	aromatic ether		An aromatic ether that is the 3-<em>O</em>-methyl ether of 3,4-dihydroxymandelic acid.
http://purl.obolibrary.org/obo/CHEBI_21647	N-acyl-L-aspartic acid	http://purl.obolibrary.org/obo/CHEBI_21654	N-acyl-aspartic acid		<small>L</small>-Aspartic acid substituted at nitrogen by an acyl group.
http://purl.obolibrary.org/obo/CHEBI_22221	acyl group	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.
http://purl.obolibrary.org/obo/CHEBI_22299	aldonate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion resulting from the deprotonation of the carboxy group of an aldonic acid.
http://purl.obolibrary.org/obo/CHEBI_22301	aldonic acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		Any carbohydrate acid formed by oxidising the aldehyde functional group of an aldose to a carboxylic acid functional group. Aldonic acids have the general formula HOCH<small><sub>2</sub></small>[CH(OH)]<em><small><sub>n</sub></small></em>C(=O)OH.
http://purl.obolibrary.org/obo/CHEBI_22323	alkyl group	http://purl.obolibrary.org/obo/CHEBI_33248	hydrocarbyl group		A univalent group ‒C<small><sub><em>n</em></sub></small>H<small><sub>2<em>n</em>+1</sub></small> derived from an alkane by removal of a hydrogen atom from any carbon atom.
http://purl.obolibrary.org/obo/CHEBI_22359	alloisoleucine	http://purl.obolibrary.org/obo/CHEBI_38264	2-amino-3-methylpentanoic acid		A 2-amino-3-methylpentanoic acid having either (2<i>R</i>,3<i>S</i>)- or (2<i>S</i>,3<i>R</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_22527	aminopurine	http://purl.obolibrary.org/obo/CHEBI_26401	purines		Any purine having at least one amino substituent.
http://purl.obolibrary.org/obo/CHEBI_22563	anion	http://purl.obolibrary.org/obo/CHEBI_24870	ion		A monoatomic or polyatomic species having one or more elementary charges of the electron.
http://purl.obolibrary.org/obo/CHEBI_22654	asparagine derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of asparagine at the amino group, the carboxy group, or the carboxamide, or from the replacement of any hydrogen of asparagine by a heteroatom. The definition normally excludes peptides containing asparagine residues.
http://purl.obolibrary.org/obo/CHEBI_22661	aspartic acid derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of aspartic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of aspartic acid by a heteroatom. The definition normally excludes peptides containing aspartic acid residues.
http://purl.obolibrary.org/obo/CHEBI_22868	bile salt	http://purl.obolibrary.org/obo/CHEBI_36078	cholanoid		A sodium salt of the conjugate of any bile acid with either glycine or taurine.
http://purl.obolibrary.org/obo/CHEBI_22918	branched-chain amino acid	http://purl.obolibrary.org/obo/CHEBI_33709	amino acid		Any  amino acid  in which the parent hydrocarbon chain has one or more alkyl substituents
http://purl.obolibrary.org/obo/CHEBI_23004	carbamoyl group	http://purl.obolibrary.org/obo/CHEBI_27207	univalent carboacyl group		The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid.
http://purl.obolibrary.org/obo/CHEBI_23042	carotene	http://purl.obolibrary.org/obo/CHEBI_35193	tetraterpene		Hydrocarbon carotenoids.
http://purl.obolibrary.org/obo/CHEBI_23075	glycotetraosylceramide	http://purl.obolibrary.org/obo/CHEBI_36520	oligoglycosylceramide		An oligoglycosylceramide consisting of a glycotetraosyl moiety attached to the ceramide oxygen with an unspecified N-acyl substituent attached to the ceramide nitrogen.
http://purl.obolibrary.org/obo/CHEBI_23229	chromanol	http://purl.obolibrary.org/obo/CHEBI_23230	chromanes		Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.
http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity	http://purl.obolibrary.org/obo/CHEBI_24431	chemical entity		Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
http://purl.obolibrary.org/obo/CHEBI_23639	deoxy sugar	http://purl.obolibrary.org/obo/CHEBI_16646	carbohydrate		Any sugar having a hydroxy group replaced with a hydrogen atom.
http://purl.obolibrary.org/obo/CHEBI_23677	diazole	http://purl.obolibrary.org/obo/CHEBI_68452	azole		An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring.
http://purl.obolibrary.org/obo/CHEBI_23867	dodecenoic acid	http://purl.obolibrary.org/obo/CHEBI_59202	straight-chain fatty acid		A C<small><sub>12</sub></small>, straight-chain fatty acid carrying a double bond at any position.
http://purl.obolibrary.org/obo/CHEBI_24271	glucosamines	http://purl.obolibrary.org/obo/CHEBI_24586	hexosamine		Any  hexosamine that is glucose in which at least one of the hydroxy groups has been replaced by an amino group.
http://purl.obolibrary.org/obo/CHEBI_24280	D-glucosyl group	http://purl.obolibrary.org/obo/CHEBI_24281	glucosyl group		The glucosyl group formed from <small>D</small>-glucopyranose.
http://purl.obolibrary.org/obo/CHEBI_24319	EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76823	EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor		An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of glutamate—ammonia ligase (EC 6.3.1.2).
http://purl.obolibrary.org/obo/CHEBI_24402	glycosphingolipid	http://purl.obolibrary.org/obo/CHEBI_26739	sphingolipid		A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid.
http://purl.obolibrary.org/obo/CHEBI_24432	biological role	http://purl.obolibrary.org/obo/CHEBI_50906	role		A role played by the molecular entity or part thereof within a biological context.
http://purl.obolibrary.org/obo/CHEBI_24470	haloamino acid	http://purl.obolibrary.org/obo/CHEBI_83820	non-proteinogenic amino acid		Any non-proteinogenic amino acid carrying at least one halo group.
http://purl.obolibrary.org/obo/CHEBI_24532	organic heterocyclic compound	http://purl.obolibrary.org/obo/CHEBI_33832	organic cyclic compound		A cyclic compound having as ring members atoms of carbon and at least of one other element.
http://purl.obolibrary.org/obo/CHEBI_24586	hexosamine	http://purl.obolibrary.org/obo/CHEBI_60926	amino monosaccharide		Any 6-carbon amino monosaccharide with at least one alcoholic hydroxy group replaced by an amino group.
http://purl.obolibrary.org/obo/CHEBI_24599	histidine derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of histidine at the amino group or the carboxy group, or from the replacement of any hydrogen of histidine by a heteroatom. The definition normally excludes peptides containing alanine residues.
http://purl.obolibrary.org/obo/CHEBI_24651	hydroxides	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH<small><sup>−</small></sup>).
http://purl.obolibrary.org/obo/CHEBI_24663	hydroxy-5beta-cholanic acid	http://purl.obolibrary.org/obo/CHEBI_36248	5beta-cholanic acids		Any member of the class of 5β-cholanic acids carrying at least one hydroxy group at unspecified position.
http://purl.obolibrary.org/obo/CHEBI_24741	hydroxyproline	http://purl.obolibrary.org/obo/CHEBI_26273	proline derivative		A proline derivative that is proline substituted by at least one hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_24835	inorganic molecular entity	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		A molecular entity that contains no carbon.
http://purl.obolibrary.org/obo/CHEBI_24859	iodine atom	http://purl.obolibrary.org/obo/CHEBI_24473	halogen		Chemical element with atomic number 53.
http://purl.obolibrary.org/obo/CHEBI_24862	iodoamino acid	http://purl.obolibrary.org/obo/CHEBI_37142	organoiodine compound		An amino acid containing at least one iodo substituent.
http://purl.obolibrary.org/obo/CHEBI_24866	salt	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		A salt is an assembly of cations and anions.
http://purl.obolibrary.org/obo/CHEBI_24870	ion	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		A molecular entity having a net electric charge.
http://purl.obolibrary.org/obo/CHEBI_25345	methyltetrahydrofolate	http://purl.obolibrary.org/obo/CHEBI_67016	tetrahydrofolate		A group of heterocyclic compounds based on the <em>N</em>-methylated 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more <small>L</small>-glutamic acid or <small>L</small>-glutamate units.
http://purl.obolibrary.org/obo/CHEBI_25513	neutral glycosphingolipid	http://purl.obolibrary.org/obo/CHEBI_24402	glycosphingolipid		Any glycosphingolipid containing unsubstituted glycosyl moieties.
http://purl.obolibrary.org/obo/CHEBI_25634	octadecenoic acid	http://purl.obolibrary.org/obo/CHEBI_140948	fatty acid 18:1		Any member of the group of C<small><sub>18</sub></small> monounsaturated fatty acids with the double bond located at any position in the chain.
http://purl.obolibrary.org/obo/CHEBI_25701	organic oxide	http://purl.obolibrary.org/obo/CHEBI_72695	organic molecule		An oxide in which the oxygen atom is bonded to a carbon atom.
http://purl.obolibrary.org/obo/CHEBI_25710	organophosphorus compound	http://purl.obolibrary.org/obo/CHEBI_33285	heteroorganic entity		An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters.
http://purl.obolibrary.org/obo/CHEBI_25741	oxide	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		An oxide is a chemical compound of oxygen with other chemical elements.
http://purl.obolibrary.org/obo/CHEBI_25799	oxopentanoic acid	http://purl.obolibrary.org/obo/CHEBI_59644	oxo fatty acid		A C<small><sub>5</sub></small> fatty acid carrying an oxo group at any position.
http://purl.obolibrary.org/obo/CHEBI_25901	pentose	http://purl.obolibrary.org/obo/CHEBI_35381	monosaccharide		A five-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldopentose) or a ketone group at position 2 (ketopentose).
http://purl.obolibrary.org/obo/CHEBI_26020	phosphate	http://purl.obolibrary.org/obo/CHEBI_26079	phosphoric acid derivative		Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom.
http://purl.obolibrary.org/obo/CHEBI_26167	polar amino acid	http://purl.obolibrary.org/obo/CHEBI_33709	amino acid		Any amino acid whose side chain is capable of forming one or more hydrogen bonds.
http://purl.obolibrary.org/obo/CHEBI_26214	porphyrins	http://purl.obolibrary.org/obo/CHEBI_36309	cyclic tetrapyrrole		Natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the α-positions by four methine groups to form a macrocyclic structure.
http://purl.obolibrary.org/obo/CHEBI_26469	quaternary nitrogen compound	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen.
http://purl.obolibrary.org/obo/CHEBI_26714	sodium salt	http://purl.obolibrary.org/obo/CHEBI_35479	alkali metal salt		Any alkali metal salt having sodium(1+) as the cation.
http://purl.obolibrary.org/obo/CHEBI_26764	steroid hormone	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		Any steroid that acts as hormone.
http://purl.obolibrary.org/obo/CHEBI_26806	succinate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of succinic acid.
http://purl.obolibrary.org/obo/CHEBI_26820	sulfates	http://purl.obolibrary.org/obo/CHEBI_37826	sulfuric acid derivative		Salts and esters of sulfuric acid
http://purl.obolibrary.org/obo/CHEBI_26873	terpenoid	http://purl.obolibrary.org/obo/CHEBI_24913	isoprenoid		Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group.
http://purl.obolibrary.org/obo/CHEBI_26932	tetrapyrrole	http://purl.obolibrary.org/obo/CHEBI_38077	polypyrrole		A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
http://purl.obolibrary.org/obo/CHEBI_26935	tetraterpenoid	http://purl.obolibrary.org/obo/CHEBI_26873	terpenoid		Any terpenoid derived from a tetraterpene. The term includes compounds in which the C40 skeleton of the parent tetraterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
http://purl.obolibrary.org/obo/CHEBI_27325	xanthophyll	http://purl.obolibrary.org/obo/CHEBI_23044	carotenoid		A subclass of carotenoids consisting of the oxygenated carotenes.
http://purl.obolibrary.org/obo/CHEBI_27468	5,6-dihydrothymine	http://purl.obolibrary.org/obo/CHEBI_38337	pyrimidone		A pyrimidone obtained by formal addition of hydrogen across the 5,6-position of thymine.
http://purl.obolibrary.org/obo/CHEBI_27470	folic acid	http://purl.obolibrary.org/obo/CHEBI_51569	N-acyl-amino acid		An <em>N</em>-acyl-amino acid that is a form of the water-soluble vitamin B<small><sub>9</sub></small>. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
http://purl.obolibrary.org/obo/CHEBI_27584	aldosterone	http://purl.obolibrary.org/obo/CHEBI_139590	primary alpha-hydroxy ketone		A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
http://purl.obolibrary.org/obo/CHEBI_27638	cobalt atom	http://purl.obolibrary.org/obo/CHEBI_88184	metal allergen		A cobalt group element atom that has atomic number 27.
http://purl.obolibrary.org/obo/CHEBI_27693	sitosterol	http://purl.obolibrary.org/obo/CHEBI_35348	3beta-sterol		A member of the class of phytosterols that is stigmast-5-ene substituted by a β-hydroxy group at position 3.
http://purl.obolibrary.org/obo/CHEBI_27891	S-sulfo-L-cysteine	http://purl.obolibrary.org/obo/CHEBI_37996	organic thiosulfate		An <em>S</em>-substituted <small>L</small>-cysteine where the <em>S</em>-substituent is specified as a sulfo group.
http://purl.obolibrary.org/obo/CHEBI_28050	homocarnosine	http://purl.obolibrary.org/obo/CHEBI_51569	N-acyl-amino acid		A histidine derivative that is histidine in which one of the hydrogens attached to the α-amino group has been replaced by a 4-aminobutanoyl group.
http://purl.obolibrary.org/obo/CHEBI_28087	glycogen	http://purl.obolibrary.org/obo/CHEBI_24384	glycogens		A polydisperse, highly branched glucan composed of chains of <small>D</small>-glucopyranose residues in α(1→4) glycosidic linkage, joined together by α(1→6) glycosidic linkages. A small number of α(1→3) glycosidic linkages and some cumulative α(1→6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.
http://purl.obolibrary.org/obo/CHEBI_28815	heparan sulfate	http://purl.obolibrary.org/obo/CHEBI_35721	heparan sulfates		A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.
http://purl.obolibrary.org/obo/CHEBI_28867	O-propanoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine compound having propanoyl as the acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_28892	ganglioside	http://purl.obolibrary.org/obo/CHEBI_17761	ceramide		A molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids linked on the sugar chain.
http://purl.obolibrary.org/obo/CHEBI_28918	(R)-adrenaline	http://purl.obolibrary.org/obo/CHEBI_194548	4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol		The <i>R</i>-enantiomer of adrenaline. It is a hormone secreted by the adrenal glands resulting in the 'fight-or-flight' response.
http://purl.obolibrary.org/obo/CHEBI_28963	amino sugar	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups.
http://purl.obolibrary.org/obo/CHEBI_29101	sodium(1+)	http://purl.obolibrary.org/obo/CHEBI_37246	elemental sodium		A monoatomic monocation obtained from sodium.
http://purl.obolibrary.org/obo/CHEBI_29103	potassium(1+)	http://purl.obolibrary.org/obo/CHEBI_37247	elemental potassium		A monoatomic monocation obtained from potassium.
http://purl.obolibrary.org/obo/CHEBI_30661	thyronine	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		A tyrosine derivative where the phenolic hydrogen of tyrosine is substituted by 4-hydroxyphenyl.
http://purl.obolibrary.org/obo/CHEBI_32563	lysinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of lysine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32564	lysinium(1+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of lysine, having two cationic amino groups and an anionic carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32627	leucinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of leucine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32628	leucinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of leucine, arising from protonation of the amino group.
http://purl.obolibrary.org/obo/CHEBI_32660	asparaginate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of asparagine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32871	prolinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of proline, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32872	prolinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of proline, arising from protonation of the amino group.
http://purl.obolibrary.org/obo/CHEBI_32988	amide	http://purl.obolibrary.org/obo/CHEBI_51143	nitrogen molecular entity		An amide is a derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
http://purl.obolibrary.org/obo/CHEBI_33232	application	http://purl.obolibrary.org/obo/CHEBI_50906	role		Intended use of the molecular entity or part thereof by humans.
http://purl.obolibrary.org/obo/CHEBI_33238	monoatomic entity	http://purl.obolibrary.org/obo/CHEBI_33259	elemental molecular entity		A monoatomic entity is a molecular entity consisting of a single atom.
http://purl.obolibrary.org/obo/CHEBI_33240	coordination entity	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands).
http://purl.obolibrary.org/obo/CHEBI_33245	organic fundamental parent	http://purl.obolibrary.org/obo/CHEBI_37175	organic hydride		An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system.
http://purl.obolibrary.org/obo/CHEBI_33248	hydrocarbyl group	http://purl.obolibrary.org/obo/CHEBI_33249	organyl group		A univalent group formed by removing a hydrogen atom from a hydrocarbon.
http://purl.obolibrary.org/obo/CHEBI_33250	atom	http://purl.obolibrary.org/obo/CHEBI_24431	chemical entity		A chemical entity constituting the smallest component of an element having the chemical properties of the element.
http://purl.obolibrary.org/obo/CHEBI_33253	nucleon	http://purl.obolibrary.org/obo/CHEBI_36347	nuclear particle		Heavy nuclear particle: proton or neutron.
http://purl.obolibrary.org/obo/CHEBI_33259	elemental molecular entity	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		A molecular entity all atoms of which have the same atomic number.
http://purl.obolibrary.org/obo/CHEBI_33285	heteroorganic entity	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
http://purl.obolibrary.org/obo/CHEBI_33296	alkali metal molecular entity	http://purl.obolibrary.org/obo/CHEBI_33674	s-block molecular entity		A molecular entity containing one or more atoms of an alkali metal.
http://purl.obolibrary.org/obo/CHEBI_33299	alkaline earth molecular entity	http://purl.obolibrary.org/obo/CHEBI_33674	s-block molecular entity		An alkaline earth molecular entity is a molecular entity containing one or more atoms of an alkaline earth metal.
http://purl.obolibrary.org/obo/CHEBI_33300	pnictogen	http://purl.obolibrary.org/obo/CHEBI_33560	p-block element atom		Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth.
http://purl.obolibrary.org/obo/CHEBI_33302	pnictogen molecular entity	http://purl.obolibrary.org/obo/CHEBI_33675	p-block molecular entity		A p-block molecular entity containing any pnictogen.
http://purl.obolibrary.org/obo/CHEBI_33303	chalcogen	http://purl.obolibrary.org/obo/CHEBI_33560	p-block element atom		Any p-block element belonging to the group 16 family of the periodic table.
http://purl.obolibrary.org/obo/CHEBI_33304	chalcogen molecular entity	http://purl.obolibrary.org/obo/CHEBI_33675	p-block molecular entity		Any p-block molecular entity containing a chalcogen.
http://purl.obolibrary.org/obo/CHEBI_33318	main group element atom	http://purl.obolibrary.org/obo/CHEBI_33250	atom		An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table.
http://purl.obolibrary.org/obo/CHEBI_33452	benzylic group	http://purl.obolibrary.org/obo/CHEBI_33249	organyl group		Arylmethyl groups and derivatives formed by substitution: ArCR<small><sub>2</sub></small>‒.
http://purl.obolibrary.org/obo/CHEBI_33521	metal atom	http://purl.obolibrary.org/obo/CHEBI_33250	atom		An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity.
http://purl.obolibrary.org/obo/CHEBI_33560	p-block element atom	http://purl.obolibrary.org/obo/CHEBI_33318	main group element atom		Any main group element atom belonging to the p-block of the periodic table.
http://purl.obolibrary.org/obo/CHEBI_33563	glycolipid	http://purl.obolibrary.org/obo/CHEBI_35740	liposaccharide		Any member of class of 1,2-di-<em>O</em>-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar part acylated by one or more fatty acids and the glycerol part may be absent.
http://purl.obolibrary.org/obo/CHEBI_33598	carbocyclic compound	http://purl.obolibrary.org/obo/CHEBI_33597	homocyclic compound		A homocyclic compound in which all of the ring members are carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_33675	p-block molecular entity	http://purl.obolibrary.org/obo/CHEBI_33579	main group molecular entity		A main group molecular entity that contains one or more atoms of a p-block element.
http://purl.obolibrary.org/obo/CHEBI_33832	organic cyclic compound	http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound		Any organic molecule that consists of atoms connected in the form of a ring.
http://purl.obolibrary.org/obo/CHEBI_33913	corrinoid	http://purl.obolibrary.org/obo/CHEBI_36309	cyclic tetrapyrrole		A derivative of the corrin nucleus, which contains four reduced or partly reduced pyrrole rings joined in a macrocycle by three =C‒ groups and one direct carbon-carbon bond linking α positions.
http://purl.obolibrary.org/obo/CHEBI_33937	macronutrient	http://purl.obolibrary.org/obo/CHEBI_33284	nutrient		Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals.
http://purl.obolibrary.org/obo/CHEBI_35193	tetraterpene	http://purl.obolibrary.org/obo/CHEBI_35186	terpene		A C<small><sub>40</sub></small> terpene.
http://purl.obolibrary.org/obo/CHEBI_35391	aspartate(1-)	http://purl.obolibrary.org/obo/CHEBI_132943	aspartate		An α-amino-acid anion that is the conjugate base of aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_35406	oxoanion	http://purl.obolibrary.org/obo/CHEBI_33273	polyatomic anion		An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen.
http://purl.obolibrary.org/obo/CHEBI_35903	oxo carboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		Any carboxylic acid anion containing at least one oxo group.
http://purl.obolibrary.org/obo/CHEBI_35942	neurotransmitter agent	http://purl.obolibrary.org/obo/CHEBI_52210	pharmacological role		A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
http://purl.obolibrary.org/obo/CHEBI_36248	5beta-cholanic acids	http://purl.obolibrary.org/obo/CHEBI_136889	5beta steroid		Members of the class of cholanic acids based on a 5β-cholane skeleton.
http://purl.obolibrary.org/obo/CHEBI_36277	bile acid salt	http://purl.obolibrary.org/obo/CHEBI_36078	cholanoid		A salt of a bile acid.
http://purl.obolibrary.org/obo/CHEBI_36357	polyatomic entity	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		Any molecular entity consisting of more than one atom.
http://purl.obolibrary.org/obo/CHEBI_36358	polyatomic ion	http://purl.obolibrary.org/obo/CHEBI_36357	polyatomic entity		An ion consisting of more than one atom.
http://purl.obolibrary.org/obo/CHEBI_36838	17-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_35350	hydroxy steroid		A hydroxy steroid carrying a hydroxy group at position 17.
http://purl.obolibrary.org/obo/CHEBI_36916	cation	http://purl.obolibrary.org/obo/CHEBI_24870	ion		A monoatomic or polyatomic species having one or more elementary charges of the proton.
http://purl.obolibrary.org/obo/CHEBI_36962	organochalcogen compound	http://purl.obolibrary.org/obo/CHEBI_33304	chalcogen molecular entity		An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
http://purl.obolibrary.org/obo/CHEBI_37164	homopolysaccharide	http://purl.obolibrary.org/obo/CHEBI_18154	polysaccharide		Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'.
http://purl.obolibrary.org/obo/CHEBI_37445	folic acids	http://purl.obolibrary.org/obo/CHEBI_176842	vitamin B9		A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more <small>L</small>-glutamic acid units.
http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity	http://purl.obolibrary.org/obo/CHEBI_36357	polyatomic entity		A molecular entity consisting of two or more chemical elements.
http://purl.obolibrary.org/obo/CHEBI_37838	carboacyl group	http://purl.obolibrary.org/obo/CHEBI_22221	acyl group		A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_38264	2-amino-3-methylpentanoic acid	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		A branched chain amino acid that consists of 3-methylpentanoic acid bearing an amino substituent at position 2.
http://purl.obolibrary.org/obo/CHEBI_38632	membrane transport modulator	http://purl.obolibrary.org/obo/CHEBI_52208	biophysical role		Any agent that affects the transport of molecular entities across a biological membrane.
http://purl.obolibrary.org/obo/CHEBI_39141	Bronsted acid	http://purl.obolibrary.org/obo/CHEBI_37527	acid		A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
http://purl.obolibrary.org/obo/CHEBI_39317	growth regulator	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		Any chemical substance that inhibits the life-cycle of an organism.
http://purl.obolibrary.org/obo/CHEBI_39745	dihydrogenphosphate	http://purl.obolibrary.org/obo/CHEBI_35780	phosphate ion		A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated.
http://purl.obolibrary.org/obo/CHEBI_41808	decane	http://purl.obolibrary.org/obo/CHEBI_18310	alkane		A straight-chain alkane with 10 carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_43433	L-alloisoleucine	http://purl.obolibrary.org/obo/CHEBI_83822	non-proteinogenic L-alpha-amino acid		An optically active form of alloisoleucine having <small>L</small>-(2<i>S</i>,3<i>R</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group	http://purl.obolibrary.org/obo/CHEBI_33249	organyl group		A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid.
http://purl.obolibrary.org/obo/CHEBI_50858	corticosteroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		A natural or synthetic analogue of the hormones secreted by the adrenal gland.
http://purl.obolibrary.org/obo/CHEBI_51422	organodiyl group	http://purl.obolibrary.org/obo/CHEBI_51446	organic divalent group		Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s).
http://purl.obolibrary.org/obo/CHEBI_52215	photochemical role	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A  chemical role played by the molecular entity or part thereof in a photochemical process.
http://purl.obolibrary.org/obo/CHEBI_58496	N-acetyl-D-amino acid anion	http://purl.obolibrary.org/obo/CHEBI_59876	N-acyl-D-alpha-amino acid anion		The conjugate base of an <em>N</em>-acetyl-<small>D</small>-amino acid.
http://purl.obolibrary.org/obo/CHEBI_58497	N-acyl-L-aspartate(2-)	http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion		Conjugate base of an <em>N</em>-acyl-<small>L</small>-aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_59549	essential fatty acid	http://purl.obolibrary.org/obo/CHEBI_26208	polyunsaturated fatty acid		Any member of the sub-set of polyunsaturated fatty acid for which there is an absolute dietary requirement.
http://purl.obolibrary.org/obo/CHEBI_59561	diamino acid anion	http://purl.obolibrary.org/obo/CHEBI_25696	organic anion		An  organic anion that is the conjugate base of diamino acid.
http://purl.obolibrary.org/obo/CHEBI_59698	phosphoric acids	http://purl.obolibrary.org/obo/CHEBI_33457	phosphorus oxoacid		Compounds containing one or more phosphoric acid units.
http://purl.obolibrary.org/obo/CHEBI_61409	dihydroxyphenylacetic acid	http://purl.obolibrary.org/obo/CHEBI_25978	phenylacetic acids		A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
http://purl.obolibrary.org/obo/CHEBI_62944	sialic acid anion	http://purl.obolibrary.org/obo/CHEBI_63551	carbohydrate acid derivative anion		A carboxylic acid anion that is the conjugate base of a sialic acid, formed by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_62978	4-hydroxyprolinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		The α-amino-acid anion formed by loss of a proton from the carboxy group of 4-hydroxyproline.
http://purl.obolibrary.org/obo/CHEBI_63137	4-hydroxyproline zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		The amino acid zwitterion formed from 4-hydroxyproline.
http://purl.obolibrary.org/obo/CHEBI_63161	glycosyl compound	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity.
http://purl.obolibrary.org/obo/CHEBI_63394	ketoaldonic acid derivative	http://purl.obolibrary.org/obo/CHEBI_63367	monosaccharide derivative		A monosaccharide derivative that is formally obtained from a ketoaldonic acid.
http://purl.obolibrary.org/obo/CHEBI_63423	alditol derivative	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		A carbohydrate derivative that is formally obtained from an alditol.
http://purl.obolibrary.org/obo/CHEBI_63430	hexitol derivative	http://purl.obolibrary.org/obo/CHEBI_63423	alditol derivative		An alditol derivative that is formally obtained from a hexitol.
http://purl.obolibrary.org/obo/CHEBI_63471	branched-chain amino-acid anion	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		A branched-chain amino acid whose α-carboxylic acid group is ionized.
http://purl.obolibrary.org/obo/CHEBI_63477	iodothyroninate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An iodothyronine whose alpha carboxylic acid group of the tyrosine is ionized (not protonated).
http://purl.obolibrary.org/obo/CHEBI_63534	monoamine	http://purl.obolibrary.org/obo/CHEBI_64365	aralkylamino compound		An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.
http://purl.obolibrary.org/obo/CHEBI_63561	ketoaldonate derivative	http://purl.obolibrary.org/obo/CHEBI_63551	carbohydrate acid derivative anion		A carbohydrate acid derivative anion that is formally obtained from a ketoaldonate.
http://purl.obolibrary.org/obo/CHEBI_66998	histidinate derivative	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A carboxylic acid anion which is a conjugate base of  a histidine derivative  having either <small>D</small>- or <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_68452	azole	http://purl.obolibrary.org/obo/CHEBI_38179	monocyclic heteroarene		Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.
http://purl.obolibrary.org/obo/CHEBI_71671	aldonate(1-)	http://purl.obolibrary.org/obo/CHEBI_33721	carbohydrate acid anion		A carbohydrate acid anion obtained by deprotonation of any aldonic acid. Major structure at pH 7.3 of aldonate compounds.
http://purl.obolibrary.org/obo/CHEBI_76823	EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_75600	EC 6.3.* (C-N bond-forming ligase) inhibitor		An EC 6.3.* (<em>C</em>‒<em>N</em> bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).
http://purl.obolibrary.org/obo/CHEBI_78117	fatty acid anion 8:0	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion containing 8 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78125	fatty acid anion 18:0	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion containing 18 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_82663	elemental iron	http://purl.obolibrary.org/obo/CHEBI_33259	elemental molecular entity		An elemental molecular entity in which all of the atoms have atomic number 26.
http://purl.obolibrary.org/obo/CHEBI_83045	dodecenoate	http://purl.obolibrary.org/obo/CHEBI_59203	straight-chain fatty acid anion		A medium-chain fatty acid anion that is the conjugate base of dodecenoic acid.
http://purl.obolibrary.org/obo/CHEBI_83811	proteinogenic amino acid derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_83820	non-proteinogenic amino acid	http://purl.obolibrary.org/obo/CHEBI_33709	amino acid		Any amino-acid that is not naturally encoded in the genetic code of any organism.
http://purl.obolibrary.org/obo/CHEBI_8504	prostanoic acid	http://purl.obolibrary.org/obo/CHEBI_35744	carbocyclic fatty acid		A carbocyclic fatty acid composed of heptanoic acid having a (1<i>S</i>,2<i>S</i>)-2-octylcyclopentyl substituent at position 7.
http://purl.obolibrary.org/obo/CHEBI_85306	D-alloisoleucine zwitterion	http://purl.obolibrary.org/obo/CHEBI_59871	D-alpha-amino acid zwitterion		A <small>D</small>-α-amino acid zwitterion resulting from a transfer of a proton from the carboxy group to the amino group of <small>D</small>-alloisoleucine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_86499	monohydroxyproline	http://purl.obolibrary.org/obo/CHEBI_24741	hydroxyproline		A hydroxy-amino acid in which the amino acid specified is proline. A "closed" class.
http://purl.obolibrary.org/obo/CHEBI_37024	2-aminoadipic acid	http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid		An α-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.
http://purl.obolibrary.org/obo/CHEBI_37627	L-glucopyranose	http://purl.obolibrary.org/obo/CHEBI_37661	glucopyranose		The <small>L</small>-enantiomer of glucopyranose.
http://purl.obolibrary.org/obo/CHEBI_38313	diazines	http://purl.obolibrary.org/obo/CHEBI_25693	organic heteromonocyclic compound		Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure).
http://purl.obolibrary.org/obo/CHEBI_3892	corticotropin	http://purl.obolibrary.org/obo/CHEBI_33694	biomacromolecule		A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The <em>N</em>-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.
http://purl.obolibrary.org/obo/CHEBI_39015	apolipoprotein	http://purl.obolibrary.org/obo/CHEBI_13850	apoprotein		Protein component on the surface of lipoprotein.
http://purl.obolibrary.org/obo/CHEBI_39022	inclusion compound	http://purl.obolibrary.org/obo/CHEBI_50967	non-covalently-bound molecular entity		A complex in which one component (the host) forms a cavity or, in the case of a crystal, a crystal lattice containing spaces in the shape of long tunnels or channels in which molecular entities of a second chemical species (the guest) are located. There is no covalent bonding between guest and host, the attraction being generally due to van der Waals forces.
http://purl.obolibrary.org/obo/CHEBI_39026	low-density lipoprotein	http://purl.obolibrary.org/obo/CHEBI_6495	lipoprotein		A class of lipoproteins of small size (18-25 nm) and low density (1.019-1.063 g/ml) particles with a core composed mainly of cholesterol esters and smaller amounts of triglycerides. The surface monolayer consists mostly of phospholipids, a single copy of apolipoprotein B-100, and free cholesterol molecules. The main function of LDL is to transport cholesterol and cholesterol esters from the liver. Excessive levels are associated with cardiovascular disease.
http://purl.obolibrary.org/obo/CHEBI_39142	Bronsted base	http://purl.obolibrary.org/obo/CHEBI_22695	base		A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
http://purl.obolibrary.org/obo/CHEBI_39144	Lewis base	http://purl.obolibrary.org/obo/CHEBI_22695	base		A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct.
http://purl.obolibrary.org/obo/CHEBI_47773	very-low-density lipoprotein cholesterol	http://purl.obolibrary.org/obo/CHEBI_50404	lipoprotein cholesterol		Cholesterol esters and free cholesterol which are contained in or bound to very low density lipoproteins (VLDL).
http://purl.obolibrary.org/obo/CHEBI_47774	low-density lipoprotein cholesterol	http://purl.obolibrary.org/obo/CHEBI_50404	lipoprotein cholesterol		Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL).
http://purl.obolibrary.org/obo/CHEBI_47775	high-density lipoprotein cholesterol	http://purl.obolibrary.org/obo/CHEBI_50404	lipoprotein cholesterol		Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL).
http://purl.obolibrary.org/obo/CHEBI_50967	non-covalently-bound molecular entity	http://purl.obolibrary.org/obo/CHEBI_36357	polyatomic entity		Systems consisting of two or more molecular entities held together by non-covalent interactions.
http://purl.obolibrary.org/obo/CHEBI_59897	EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_22587	antiviral agent		A DNA polymerase inhibitor that interferes with the activity of reverse transcriptase, EC 2.7.7.49, a viral DNA polymerase enzyme that retroviruses need in order to reproduce.
http://purl.obolibrary.org/obo/CHEBI_67011	folates	http://purl.obolibrary.org/obo/CHEBI_176842	vitamin B9		An <em>N</em>-acyl-<small>L</small>-α-amino acid anion obtained by deprotonation of any folic acid.
http://purl.obolibrary.org/obo/CHEBI_67032	O-phosphonatooxyserine(2-)	http://purl.obolibrary.org/obo/CHEBI_58945	organophosphate oxoanion		An organophosphate oxoanion that is the dianionic form of <em>O</em>-phosphoserine having anionic phosphate and carboxy functions and a protonated amino group.
http://purl.obolibrary.org/obo/CHEBI_73398	indole skeleton	http://purl.obolibrary.org/obo/CHEBI_73541	organic heterobicyclic ring		A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring.
http://purl.obolibrary.org/obo/CHEBI_76668	EC 2.7.* (P-containing group transferase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_71300	EC 2.* (transferase) inhibitor		A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*).
http://purl.obolibrary.org/obo/CHEBI_76773	EC 3.1.1.* (carboxylic ester hydrolase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76760	EC 3.1.* (ester hydrolase) inhibitor		An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*).
http://purl.obolibrary.org/obo/CHEBI_76815	EC 2.7.7.* (nucleotidyltransferase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76668	EC 2.7.* (P-containing group transferase) inhibitor		An EC 2.7.* (<em>P</em>-containing group transferase) inhibitor that interferes with the action of any nucleotidyltransferase (EC 2.7.7.*).
http://purl.obolibrary.org/obo/CHEBI_76932	pathway inhibitor	http://purl.obolibrary.org/obo/CHEBI_23924	enzyme inhibitor		An enzyme inhibitor that interferes with one or more steps in a metabolic pathway.
http://purl.obolibrary.org/obo/CHEBI_83972	3-methyl fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_67013	methyl-branched fatty acid anion		A methyl-branched fatty acid anion obtained by deprotonation of the carboxy group of any 3-methyl fatty acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_84981	2-aminoadipate(2-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		A dicarboxylic acid dianion that is the conjugate base of 2-aminoadipic acid.
http://purl.obolibrary.org/obo/CHEBI_50112	sex hormone	http://purl.obolibrary.org/obo/CHEBI_24621	hormone		Any hormone that is responsible for controlling sexual characteristics and reproductive function.
http://purl.obolibrary.org/obo/CHEBI_50689	reproductive control drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A substance used either in the prevention or facilitation of pregnancy.
http://purl.obolibrary.org/obo/CHEBI_51061	hormone receptor modulator	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
http://purl.obolibrary.org/obo/CHEBI_52209	aetiopathogenetic role	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A role played by the molecular entity or part thereof which causes the development of a pathological process.
http://purl.obolibrary.org/obo/CHEBI_76760	EC 3.1.* (ester hydrolase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76759	EC 3.* (hydrolase) inhibitor		A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*).
http://purl.obolibrary.org/obo/CHEBI_90710	receptor modulator	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.
http://purl.obolibrary.org/obo/CHEBI_60525	molybdenum cofactor(2-)	http://purl.obolibrary.org/obo/CHEBI_64775	organic anionic group		Molybdenum cofactor MoCo protonated to pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_60948	alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc	http://purl.obolibrary.org/obo/CHEBI_27150	trisaccharide		A linear trisaccharide comprising <small>D</small>-glucose (at the reducing end) having an α-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-galactosyl moiety at the 4-position.
http://purl.obolibrary.org/obo/CHEBI_61360	globoside	http://purl.obolibrary.org/obo/CHEBI_24402	glycosphingolipid		Any glycosphingolipid where the oligosaccharide component has an <em>N</em>-acetylgalactosaminyl residue at the non-reducing end.
http://purl.obolibrary.org/obo/CHEBI_61793	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-L-Fuc-(1->4)]-D-GlcNAc	http://purl.obolibrary.org/obo/CHEBI_22485	glucosamine oligosaccharide		A branched amino tetrasaccharide consisting of a sialyl residue, linked (2→3) to a galactosyl residue that in turn is linked (1→3) to a glucosaminyl residue, which is also carrying a fucosyl residue at the 4-position.
http://purl.obolibrary.org/obo/CHEBI_78069	docosatetraenoate	http://purl.obolibrary.org/obo/CHEBI_57560	long-chain fatty acid anion		A polyunsaturated fatty acid anion that is the conjugate base of docosatetraenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_79026	molybdenum cofactor(3-)	http://purl.obolibrary.org/obo/CHEBI_64775	organic anionic group		An organic anionic group derived from molybdenum cofactor(3−).  It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).
http://purl.obolibrary.org/obo/CHEBI_76832	EC 4.3.1.* (ammonia-lyase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76713	EC 4.3.* (C-N lyase) inhibitor		An EC 4.3.* (<em>C</em>‒<em>N</em> lyase) inhibitor that interferes with the action of any ammonia-lyase (EC 4.3.1.*).
http://purl.obolibrary.org/obo/CHEBI_76874	EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76655	EC 2.1.* (C1-transferase) inhibitor		An EC 2.1.* (C<small><sub>1</sub></small>-transferase) inhibitor that interferes with the action of any hydroxymethyl-, formyl- and related transferase (EC 2.1.2.*).
http://purl.obolibrary.org/obo/CHEBI_70744	Gly-Pro	http://purl.obolibrary.org/obo/CHEBI_46761	dipeptide		A dipeptide consisting of <small>L</small>-proline having a glycyl residue attached to its α-amino group.
http://purl.obolibrary.org/obo/CHEBI_70749	O-hexanoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine compound having hexanoyl as the acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_71300	EC 2.* (transferase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_23924	enzyme inhibitor		An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)
http://purl.obolibrary.org/obo/CHEBI_73779	Gly-Pro zwitterion	http://purl.obolibrary.org/obo/CHEBI_90799	dipeptide zwitterion		A peptide zwitterion obtained by transfer of a proton from the carboxy to the amino terminus of Gly-Pro.
http://purl.obolibrary.org/obo/CHEBI_76824	EC 6.4.1.* (carboxylase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_75604	EC 6.4.* (C-C bond-forming ligase) inhibitor		An EC 6.4.* (<em>C</em>‒<em>C</em> bond-forming ligase) inhibitor that interferes with the action of a carboxylating enzyme (EC 6.4.1.*).
http://purl.obolibrary.org/obo/CHEBI_86486	O-methylglutarylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine in which the acyl group specified is methylglutaryl.
http://purl.obolibrary.org/obo/CHEBI_71550	lathosterone	http://purl.obolibrary.org/obo/CHEBI_50401	cholestanoid		A cholestanoid that is 5α-cholest-7-ene substituted at position 3 by an oxo group.
http://purl.obolibrary.org/obo/CHEBI_73018	tiglylglycine	http://purl.obolibrary.org/obo/CHEBI_16180	N-acylglycine		An <em>N</em>-acylglycine that is glycine with an amine hydrogen substituted by a 2-methylbut-2-enoyl (tiglyl) group.
http://purl.obolibrary.org/obo/CHEBI_73061	O-tetradecanoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine having tetradecanoyl (myristoyl) as the acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_73074	O-stearoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine having stearoyl (octadecanoyl) as the acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_73541	organic heterobicyclic ring	http://purl.obolibrary.org/obo/CHEBI_52845	cyclic organic group		A bicyclic organic group that contains both carbon and hetero atoms.
http://purl.obolibrary.org/obo/CHEBI_86063	O-decenoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine in which the acyl group is specified as decenoyl (position of double bond not specified).
http://purl.obolibrary.org/obo/CHEBI_86065	O-dodecenoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine in which the acyl group specified is dodecenoyl.
http://purl.obolibrary.org/obo/CHEBI_86475	O-octadecenoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An  <em>O</em>-acylcarnitine in which the acyl group specified is octadecenoyl.
http://purl.obolibrary.org/obo/CHEBI_86490	C4-acylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		Any <em>O</em>-acylcarnitine in which the acyl group contains a total of 4 carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_79210	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(1-)	http://purl.obolibrary.org/obo/CHEBI_79346	anionic ganglioside		An anionic ganglioside that is the conjugate base of α-<em>N</em>-acetylneuraminyl-(2→3)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucosyl-(1↔1)-ceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_83057	Daphnia metabolite	http://purl.obolibrary.org/obo/CHEBI_83039	crustacean metabolite		A crustacean metabolite produced by the genus of small planktonic arthropods, <em>Daphnia</em>
http://purl.obolibrary.org/obo/CHEBI_89843	methylsuccinic acid	http://purl.obolibrary.org/obo/CHEBI_60911	racemate		A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-methylsuccinic acid
http://purl.obolibrary.org/obo/CHEBI_91316	(S)-methylsuccinic acid	http://purl.obolibrary.org/obo/CHEBI_91315	2-methylbutanedioic acid		A 2-methylbutanedioic acid in which the methyl group at position 2 has <i>S</i>-configuration.
http://purl.obolibrary.org/obo/CHEBI_91317	(R)-methylsuccinic acid	http://purl.obolibrary.org/obo/CHEBI_91315	2-methylbutanedioic acid		A 2-methylbutanedioic acid in which the methyl group at position 2 has <i>R</i>-configuration.
http://purl.obolibrary.org/obo/PR_000014836	sex hormone-binding globulin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SHBG gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000014841	sonic hedgehog protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000015561	osteopontin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SPP1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000016043	T-cell acute lymphocytic leukemia protein 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000016196	transcobalamin-1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TCN1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000016197	transcobalamin-2	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TCN2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000016261	serotransferrin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TF gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000016283	thyroglobulin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TG gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000016401	transmembrane emp24 domain-containing protein 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000016801	transthyretin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TTR gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000017364	von Willebrand factor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human VWF gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000017477	xanthine dehydrogenase/oxidase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human XDH gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000018335	T-cell surface glycoprotein CD8 alpha chain, signal peptide removed form	http://purl.obolibrary.org/obo/PR_000001084	T-cell surface glycoprotein CD8 alpha chain		A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed.
http://purl.obolibrary.org/obo/PR_000018337	T-cell surface glycoprotein CD8 beta chain, signal peptide removed form	http://purl.obolibrary.org/obo/PR_000001085	T-cell surface glycoprotein CD8 beta chain		A T-cell surface glycoprotein CD8 beta chain that has had the signal peptide removed.
http://purl.obolibrary.org/obo/PR_000018381	CD48 molecule proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A CD48 molecule that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018390	L-selectin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An L-selectin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018395	angiotensin-converting enzyme proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An angiotensin-converting enzyme that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018406	cell adhesion molecule CEACAM8 proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A cell adhesion molecule CEACAM8 that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018546	Thy-1 membrane glycoprotein proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A Thy-1 membrane glycoprotein that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018568	low affinity immunoglobulin epsilon Fc receptor proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A low affinity immunoglobulin epsilon Fc receptor that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018594	scavenger receptor cysteine-rich type 1 protein M130 proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A scavenger receptor cysteine-rich type 1 protein M130 that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018603	transferrin receptor protein 1 proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A transferrin receptor protein 1 that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018606	tumor necrosis factor ligand superfamily member 5 proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A tumor necrosis factor ligand superfamily member 5 that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018645	C-C motif chemokine 18 proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A C-C motif chemokine 18 that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018809	collagen alpha-1(III) chain proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A collagen alpha-1(III) chain that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018937	alpha-2-HS-glycoprotein proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An alpha-2-HS-glycoprotein that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018950	albumin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An albumin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018969	alkaline phosphatase, placental type proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An alkaline phosphatase, placental type that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000019010	apolipoprotein A-I proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An apolipoprotein A-I that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000019013	apolipoprotein A-II proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An apolipoprotein A-II that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000019110	beta-2-microglobulin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A beta-2-microglobulin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000019500	C-reactive protein proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A C-reactive protein that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000019705	dihydropyrimidine dehydrogenase [NADP(+)] proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A dihydropyrimidine dehydrogenase [NADP(+)] that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000019973	gastrin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A gastrin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000019980	pro-glucagon proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A pro-glucagon that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000020062	progranulin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A progranulin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000020180	haptoglobin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A haptoglobin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000020230	iduronate 2-sulfatase proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		An iduronate 2-sulfatase that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000020329	integrin alpha-IIb proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000009127	integrin alpha-IIb		An integrin alpha-IIb that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000020497	lactotransferrin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000009978	lactotransferrin		A lactotransferrin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000020610	72 kDa type IV collagenase proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000010479	72 kDa type IV collagenase		A 72 kDa type IV collagenase that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000021010	plasminogen proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000012867	plasminogen		A plasminogen that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_O75636	ficolin-3 (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A ficolin-3 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P00450	ceruloplasmin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A ceruloplasmin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P00747	plasminogen (human)	http://purl.obolibrary.org/obo/PR_000012867	plasminogen		A plasminogen that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P01009	alpha-1-antitrypsin (human)	http://purl.obolibrary.org/obo/PR_000014678	alpha-1-antitrypsin		An alpha-1-antitrypsin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02741	C-reactive protein (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A C-reactive protein that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02766	transthyretin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A transthyretin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02787	serotransferrin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A serotransferrin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P04141	granulocyte-macrophage colony-stimulating factor (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A granulocyte-macrophage colony-stimulating factor that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P07477	serine protease 1 (human)	http://purl.obolibrary.org/obo/PR_000013318	serine protease 1		A serine protease 1 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P08253	72 kDa type IV collagenase (human)	http://purl.obolibrary.org/obo/PR_000010479	72 kDa type IV collagenase		A 72 kDa type IV collagenase that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P10451	osteopontin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An osteopontin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P16581	E-selectin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An E-selectin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P20061	transcobalamin-1 (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A transcobalamin-1 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P20062	transcobalamin-2 (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A transcobalamin-2 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P22891	vitamin K-dependent protein Z (human)	http://purl.obolibrary.org/obo/PR_000013275	vitamin K-dependent protein Z		A vitamin K-dependent protein Z that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P32754	4-hydroxyphenylpyruvate dioxygenase (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P35858	insulin-like growth factor-binding protein complex acid labile subunit (human)	http://purl.obolibrary.org/obo/PR_000008946	insulin-like growth factor-binding protein complex acid labile chain		An insulin-like growth factor-binding protein complex acid labile chain that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P47989	xanthine dehydrogenase/oxidase (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A xanthine dehydrogenase/oxidase that is encoded in the genome of human.
http://purl.obolibrary.org/obo/HP_0012762	Cerebral white matter atrophy	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		The presence of atrophy (wasting) of the cerebral white matter.
http://purl.obolibrary.org/obo/HP_0012767	Abnormal placental size	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		A deviation from normal size of the placenta.
http://purl.obolibrary.org/obo/HP_0012776	Abnormal ciliary body morphology	http://purl.obolibrary.org/obo/HP_0000553	Abnormal uvea morphology		A structural anomaly of the ciliary body.
http://purl.obolibrary.org/obo/HP_0012777	Retinal neoplasm	http://purl.obolibrary.org/obo/HP_0100012	Neoplasm of the eye		A benign or malignant tumor (abnormal growth of tissue) of the retina.
http://purl.obolibrary.org/obo/HP_0012804	Corneal ulceration	http://purl.obolibrary.org/obo/HP_0011495	Abnormal corneal epithelium morphology		Disruption of the epithelial layer of the cornea with involvement of the underlying stroma.
http://purl.obolibrary.org/obo/HP_0012817	Noncompaction cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy		A type of cardiomyopathy characterized anatomically by deep trabeculations in the ventricular wall, which define recesses communicating with the main ventricular chamber.
http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology	http://purl.obolibrary.org/obo/HP_0012864	Abnormal sperm morphology		A structural abnormality of the sperm head.
http://purl.obolibrary.org/obo/HP_0025032	Abnormality of digestive system physiology	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		A functional anomaly of the digestive system.
http://purl.obolibrary.org/obo/HP_0025065	Abnormal mean corpuscular volume	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.
http://purl.obolibrary.org/obo/HP_0025074	Abnormal QRS complex	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram.
http://purl.obolibrary.org/obo/HP_0025133	Abnormal serum estradiol	http://purl.obolibrary.org/obo/HP_0025132	Abnormal circulating estrogen level		A deviation from normal concentrations of estradiol in the circulation.
http://purl.obolibrary.org/obo/HP_0030038	Enchondroma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A solitary, benign, intramedullary cartilage tumor that is often found in the short tubular bones of the hands and feet, distal femur, and proximal humerus.
http://purl.obolibrary.org/obo/HP_0030044	Flexion contracture of digit	http://purl.obolibrary.org/obo/HP_0001371	Flexion contracture		A bent (flexed) finger or toe joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.
http://purl.obolibrary.org/obo/HP_0030047	Abnormal lateral ventricle morphology	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		A morphological anomaly of the lateral ventricle.
http://purl.obolibrary.org/obo/HP_0030063	Neuroepithelial neoplasm	http://purl.obolibrary.org/obo/HP_0030061	Neuroectodermal neoplasm		A neoplasm composed of neural epithelium, not necessarily a neoplasm located in the neural epithelium or neuroepithelium.
http://purl.obolibrary.org/obo/HP_0030126	Abnormal endometrium morphology	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		An anomaly of the inner mucous membrane of the uterus.
http://purl.obolibrary.org/obo/HP_0030179	Abnormal peripheral action potential amplitude	http://purl.obolibrary.org/obo/HP_0003134	Abnormality of peripheral nerve conduction		An anomaly in the magnitude of the action potential along a peripheral nerve, that is, of the rapid rise and fall of the electrical membrane potential of the nerve.
http://purl.obolibrary.org/obo/HP_0030239	Hypoplasia of the upper arm musculature	http://purl.obolibrary.org/obo/HP_0009016	Upper limb muscle hypoplasia		Underdevelopment of the musculature of the upper arm, which may include the deltoid, the triceps, the biceps, and the brachioradialis.
http://purl.obolibrary.org/obo/HP_0030255	Large intestinal polyposis	http://purl.obolibrary.org/obo/HP_0200008	Intestinal polyposis		The presence of multiple polyps in the large intestine.
http://purl.obolibrary.org/obo/HP_0030299	Abnormal distal femoral metaphysis morphology	http://purl.obolibrary.org/obo/HP_0006489	Abnormal femoral metaphysis morphology		An anomaly of the metaphysis of the distal femur (close to the knee).
http://purl.obolibrary.org/obo/HP_0030313	Abnormal periosteum morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		An anomalous structure of the periosteum, i.e., of the membrane that covers the outer surface of bones.
http://purl.obolibrary.org/obo/HP_0030319	Weakness of facial musculature	http://purl.obolibrary.org/obo/HP_0000301	Abnormality of facial musculature		Reduced strength of one or more muscles innervated by the facial nerve (the seventh cranial nerve).
http://purl.obolibrary.org/obo/HP_0030345	Abnormal circulating luteinizing hormone concentration	http://purl.obolibrary.org/obo/HP_0030338	Abnormal circulating gonadotropin concentration		An anomaly of the circulating level of luteinizing hormone (LH).
http://purl.obolibrary.org/obo/HP_0030361	Abnormal circulating eicosanoid concentration	http://purl.obolibrary.org/obo/HP_0011022	Abnormal circulating unsaturated fatty acid concentration		Any deviation from the normal concentration in the blood circulation of an icosanoid (also known as eicosanoids). These are signaling molecules derived from oxidation of 20-carbon fatty acids. Most are produced from arachidonic acid, a 20-carbon polyunsaturated fatty acid (5,8,11,14-eicosatetraenoic acid).
http://purl.obolibrary.org/obo/HP_0030405	Pancreatic endocrine tumor	http://purl.obolibrary.org/obo/HP_0100634	Neuroendocrine neoplasm		A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas.
http://purl.obolibrary.org/obo/HP_0030421	Epididymal neoplasm	http://purl.obolibrary.org/obo/HP_0010785	Gonadal neoplasm		A tumor (abnormal growth of tissue) of the epididymis, an duct that transports spermatozoa from the testis to the vas deferens.
http://purl.obolibrary.org/obo/HP_0030454	Abnormal electrooculogram	http://purl.obolibrary.org/obo/HP_0030453	Abnormal visual electrophysiology		The clinical electro-oculogram (EOG) is an electrophysiological test of function of the outer retina and retinal pigment epithelium (RPE) in which changes in electrical potential across the RPE are recorded during successive periods of dark and light adaptation.
http://purl.obolibrary.org/obo/HP_0030466	Abnormal full-field electroretinogram	http://purl.obolibrary.org/obo/HP_0000512	Abnormal electroretinogram		An anomaly observed by full-field electroretinogram (ffERG). The ffERG measures the light-induced electrical activity of the retina at the corneal surface. Specifically, the ffERG records the global or total retinal electrical response to a full-field (Ganzfield) light stimulus. Isolation of the rod and cone components has important diagnostic value in differentiating between various retinal diseases. Modifying the properties of the light-stimulus (wavelength, strength, and flicker rate) as well as the adaptive state of the retina can separate the rod and cone functions of the ffERG.
http://purl.obolibrary.org/obo/HP_0030493	Abnormal foveal pigmentation	http://purl.obolibrary.org/obo/HP_0008002	Abnormal macular pigmentation		Increased or decreased pigmentation in the fovea.
http://purl.obolibrary.org/obo/HP_0030498	Macular thickening	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		Abnormal increase in retinal thickness in the macular area observed on fundoscopy or fundus imaging.
http://purl.obolibrary.org/obo/HP_0030500	Yellow/white macular lesion	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		A type of white and/or yellow lesion located anywhere within the macula. These lesions can be flat or raised and can vary in size from very small to bigger.
http://purl.obolibrary.org/obo/HP_0030502	Retinoschisis	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Splitting of the neuroretinal layers of the retina.
http://purl.obolibrary.org/obo/HP_0030666	Retinal neovascularization	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		In ischemic retinal disease, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels. Ischemia invariably leads to the upregulation of Vascular Endothelial Growth Factor (VEGF) production. Most frequently the new vessels grow internal to the plane of the retina. However, intraretinal proliferation of new vessels can also occur.
http://purl.obolibrary.org/obo/HP_0030670	Hamartoma of the orbital region	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the orbital region.
http://purl.obolibrary.org/obo/HP_0030674	Antenatal onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		Onset prior to birth.
http://purl.obolibrary.org/obo/HP_0030693	Supratentorial neoplasm	http://purl.obolibrary.org/obo/HP_0030692	Brain neoplasm		A benign or malignant neoplasm that occurs within the intracranial cavity above the tentorium cerebelli.
http://purl.obolibrary.org/obo/HP_0030724	Central nervous system cyst	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		A fluid-filled sac (cyst) located within the central nervous system.
http://purl.obolibrary.org/obo/HP_0030736	Sacrococcygeal teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		A teratoma arising in the sacro-coccygeal region.
http://purl.obolibrary.org/obo/HP_0030760	Renal fibrosis	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Renal fibrosis is the consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease.
http://purl.obolibrary.org/obo/HP_0030807	Abnormal nail growth	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Nail whose growth pattern or speed deviates from normal.
http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		An anomalous (adventitious) sound produced by the breathing process.
http://purl.obolibrary.org/obo/HP_0030853	Heterotaxy	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		An abnormality in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body.
http://purl.obolibrary.org/obo/HP_0030870	Abnormality of spinal facet joint	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		An anomaly of the small joints located between and behind adjacent vertebrae.
http://purl.obolibrary.org/obo/HP_0040007	Absent pigmentation of chest	http://purl.obolibrary.org/obo/HP_0200098	Absent skin pigmentation		Lack of skin pigmentation (coloring) of the chest.
http://purl.obolibrary.org/obo/HP_0040049	Macular edema	http://purl.obolibrary.org/obo/HP_0031527	Retinal edema		Thickening of the retina that takes place due to accumulation of extracellular fluid in the macula as a nonspecific response to blood-retinal barrier breakdown. It can either have a cystoid aspect in the fovea, or a more diffuse aspect.
http://purl.obolibrary.org/obo/HP_0040088	Abnormal lymphocyte count	http://purl.obolibrary.org/obo/HP_0011893	Abnormal leukocyte count		Any abnormality in the total number of lymphocytes in the blood.
http://purl.obolibrary.org/obo/HP_0040096	Neoplasm of the inner ear	http://purl.obolibrary.org/obo/HP_0012780	Neoplasm of the ear		A tumor (abnormal growth of tissue) of the inner ear.
http://purl.obolibrary.org/obo/HP_0040121	Abnormality of the acoustic reflex	http://purl.obolibrary.org/obo/HP_0004454	Abnormal middle ear reflexes		An abnormality in the reflexive contraction of the middle-ear muscles in response to sound stimulation.
http://purl.obolibrary.org/obo/HP_0040188	Osteochondrosis	http://purl.obolibrary.org/obo/HP_0100323	Juvenile aseptic necrosis		Abnormal growth ossification centers in children. Initially a degeneration/ necrosis followed by regeneration or recalcification.
http://purl.obolibrary.org/obo/HP_0040223	Pulmonary hemorrhage	http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage		Pulmonary hemorrhage is a bleeding within the lungs. Older children and adults may spit blood or bloody sputum. Neonates, infants and young children usually do not spit up blood. Anemia, pulmonary infiltrates, increasingling bloody return on BAL and the presence of hemosiderin-laden macrophages in broncho-alveolar lavage (BAL) fluid or lung biopsy can diagnose lung bleeding. Alveolar macrophages contain phagocytosed red blood cells and stain positive for hemosiderin, a product of hemoglobin degradation, after about 48-72 hours following pulmonary hemorraghe. Previous or recurrent bleeding can thus be distinguished from fresh events. A differentiation into local or diffuse is of importance. Also differentiate if pulmonary hemorrhage is due to a primary lung disorder or a manifestation of a systemic disease.
http://purl.obolibrary.org/obo/HP_0040274	Adenocarcinoma of the small intestine	http://purl.obolibrary.org/obo/HP_0040273	Adenocarcinoma of the intestines		A malignant epithelial tumor with a glandular organization that originates in the small intestine.
http://purl.obolibrary.org/obo/HP_0045005	Neural tube defect	http://purl.obolibrary.org/obo/HP_0410043	Abnormal neural tube morphology		A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine.
http://purl.obolibrary.org/obo/HP_0045007	Abnormal substantia nigra morphology	http://purl.obolibrary.org/obo/HP_0002418	Abnormal midbrain morphology		A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry.
http://purl.obolibrary.org/obo/HP_0045056	Abnormal circulating alpha-fetoprotein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of alpha-fetoprotein in the blood circulation.
http://purl.obolibrary.org/obo/HP_0430009	Hypoplasia of eyelid	http://purl.obolibrary.org/obo/HP_0011226	Aplasia/Hypoplasia of the eyelid		Developmental hypoplasia of the eyelid.
http://purl.obolibrary.org/obo/HP_3000022	Abnormal external ear cartilage morphology	http://purl.obolibrary.org/obo/HP_0002763	Abnormal cartilage morphology		An abnormality of a cartilage of external ear.
http://purl.obolibrary.org/obo/HP_3000034	Abnormality nasal septum cartilage morphology	http://purl.obolibrary.org/obo/HP_0010937	Abnormal nasal skeleton morphology		An abnormality of a cartilage of nasal septum.
http://purl.obolibrary.org/obo/HP_3000040	Abnormality of ethmoid sinus	http://purl.obolibrary.org/obo/HP_0000245	Abnormal paranasal sinus morphology		An abnormality of an ethmoid sinus.
http://purl.obolibrary.org/obo/HP_3000062	Abnormal internal carotid artery morphology	http://purl.obolibrary.org/obo/HP_3000036	Abnormal head blood vessel morphology		An abnormality of an internal carotid artery.
http://purl.obolibrary.org/obo/HP_3000075	Abnormal lingual nerve morphology	http://purl.obolibrary.org/obo/HP_0045010	Abnormal peripheral nerve morphology by anatomical site		Any structural anomaly of a lingual nerve.
http://purl.obolibrary.org/obo/HP_3000077	Abnormal mandible condylar process morphology	http://purl.obolibrary.org/obo/HP_0031816	Abnormal oral morphology		An abnormality of a mandible condylar process.
http://purl.obolibrary.org/obo/HsapDv_0000002	embryonic stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Prenatal stage that starts with fertilization and ends with a fully formed embryo, before undergoing last development during the fetal stage.
http://purl.obolibrary.org/obo/HsapDv_0000037	fetal stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Prenatal stage that starts with the fully formed embryo and ends at birth.
http://purl.obolibrary.org/obo/MPATH_124	infarct	http://purl.obolibrary.org/obo/MPATH_105	circulatory disorder		An area of necrosis resulting from a sudden cessation of arterial or venous blood supply.
http://purl.obolibrary.org/obo/MPATH_27	arthrosis	http://purl.obolibrary.org/obo/MPATH_25	tissue specific degenerative process		Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process.
http://purl.obolibrary.org/obo/MPATH_287	islet cell adenoma	http://purl.obolibrary.org/obo/MPATH_270	adenoma		Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0).
http://purl.obolibrary.org/obo/MPATH_34	amyloid deposition	http://purl.obolibrary.org/obo/MPATH_33	intracellular and extracellular accumulation		Extracellular deposition of amyloid protein.
http://purl.obolibrary.org/obo/MPATH_387	odontoma	http://purl.obolibrary.org/obo/MPATH_379	odontogenic tumor		Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0).
http://purl.obolibrary.org/obo/MPATH_429	myxomatous tumor	http://purl.obolibrary.org/obo/MPATH_404	soft tissue tumor		Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix.
http://purl.obolibrary.org/obo/MPATH_574	nephroblastomatosis	http://purl.obolibrary.org/obo/MPATH_64	developmental dysplasia		Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests.
http://purl.obolibrary.org/obo/MPATH_622	steatosis	http://purl.obolibrary.org/obo/MPATH_33	intracellular and extracellular accumulation		Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells.
http://purl.obolibrary.org/obo/MPATH_718	pre-sacral teratoma	http://purl.obolibrary.org/obo/MPATH_322	teratoma		Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine.
http://purl.obolibrary.org/obo/MPATH_98	lymphangiectasis	http://purl.obolibrary.org/obo/MPATH_89	cardiovascular developmental defect		A stretching and widening of the lymphatic vessels.
http://purl.obolibrary.org/obo/NBO_0000416	vestibulo-ocular reflex	http://purl.obolibrary.org/obo/NBO_0000411	cranial nerve related reflex		"A reflex eye movement that stabilizes images on the retina during head movement by producing an eye movement in the direction opposite to head movement, thus preserving the image on the center of the visual field." [wikipedia:Vestibulo-ocular_reflex]
http://purl.obolibrary.org/obo/NBO_0000446	visual pursuit	http://purl.obolibrary.org/obo/NBO_0000314	visual behavior		Selective tracking that follows a moving object by eye.
http://purl.obolibrary.org/obo/NBO_0000605	sexual inhibition	http://purl.obolibrary.org/obo/NBO_0000011	social behavior		"A social behavior characterised by conscious or unconscious constraint or curtailment of behavior relating to specific sexual matters or practices." [wikipedia:Sexual_inhibition]
http://purl.obolibrary.org/obo/UBERON_0035139	anterior nasal spine of maxilla	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		A pointed projection at the front extremity of the intermaxillary suture.
http://purl.obolibrary.org/obo/UBERON_0035431	mediastinal pleura	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		The parietal pleura that lines the mediastinum.
http://purl.obolibrary.org/obo/UBERON_0035819	abdominopelvic cavity	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity.
http://purl.obolibrary.org/obo/UBERON_0035105	sac of scrotum	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Any of the two testis-carrying compartments of the scrotum.
http://purl.obolibrary.org/obo/UBERON_0035108	temporalis fascia	http://purl.obolibrary.org/obo/UBERON_0008982	fascia		The temporal fascia covers the Temporalis muscle. It is a strong, fibrous investment, covered, laterally, by the Auricularis anterior and superior, by the galea aponeurotica, and by part of the Orbicularis oculi. The superficial temporal vessels and the auriculotemporal nerve cross it from below upward. Above, it is a single layer, attached to the entire extent of the superior temporal line; but below, where it is fixed to the zygomatic arch, it consists of two layers, one of which is inserted into the lateral, and the other into the medial border of the arch. A small quantity of fat, the orbital branch of the superficial temporal artery, and a filament from the zygomatic branch of the maxillary nerve, are contained between these two layers. It affords attachment by its deep surface to the superficial fibers of the Temporalis.
http://purl.obolibrary.org/obo/UBERON_0035109	plantar nerve	http://purl.obolibrary.org/obo/UBERON_0003431	leg nerve		A nerve that innervates the sole of the foot. Planar nerves arise from the posterior branch of the tibial nerve.
http://purl.obolibrary.org/obo/UBERON_0035784	seminal clot	http://purl.obolibrary.org/obo/UBERON_0001968	semen		A portion of semen in a coagulated state.
http://purl.obolibrary.org/obo/UBERON_0035849	orbital margin	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The mostly sharp edge of the orbital opening that is the peripheral border of the base of the pyramidal orbit.
http://purl.obolibrary.org/obo/CHEBI_136505	homocysteine derivative	http://purl.obolibrary.org/obo/CHEBI_83812	non-proteinogenic amino acid derivative		A non-proteinogenic amino acid derivative resulting from reaction of homocysteine at the amino group, the carboxy group, or the side-chain amino group, or from the replacement of any hydrogen of homocysteine by a heteroatom. The definition normally excludes peptides containing homocysteine residues.
http://purl.obolibrary.org/obo/GO_0140013	meiotic nuclear division	http://purl.obolibrary.org/obo/GO_1903046	meiotic cell cycle process		One of the two nuclear divisions that occur as part of the meiotic cell cycle.
http://purl.obolibrary.org/obo/CHEBI_136849	3-oxo-Delta(4)-steroid group	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		An organic group derived from any 3-oxo-Δ<small><sup>4</small></sup>-steroid.
http://purl.obolibrary.org/obo/CHEBI_136859	pro-agent	http://purl.obolibrary.org/obo/CHEBI_33232	application		A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent.
http://purl.obolibrary.org/obo/CHEBI_136889	5beta steroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		Any steroid that has β-configuration at position 5.
http://purl.obolibrary.org/obo/HP_0031285	Abnormal perifollicular morphology	http://purl.obolibrary.org/obo/HP_0000951	Abnormality of the skin		Any structural anomaly in the areas surrounding the hair follicles.
http://purl.obolibrary.org/obo/HP_0031292	Cutaneous abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A circumscribed area of pus or necrotic debris in the skin (within the epidermis or dermis).
http://purl.obolibrary.org/obo/HP_0031367	Metaphyseal striations	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Longitudinal densities on radiographs located in a metaphysis (the narrow region of a long bone between the epiphysis and the diaphysis).
http://purl.obolibrary.org/obo/HP_0031437	Pregnancy exposure	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants.
http://purl.obolibrary.org/obo/HP_0031442	Abnormal tricuspid chordae tendinae morphology	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		Any structural anomaly of the chordae tendinae of the tricuspid valve. The chordae tendineae connect the papillary muscles to the tricuspid valve.
http://purl.obolibrary.org/obo/HP_0031459	Soft tissue neoplasm	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms.
http://purl.obolibrary.org/obo/HP_0031475	Status epilepticus without prominent motor symptoms	http://purl.obolibrary.org/obo/HP_0002133	Status epilepticus		There is inconclusive evidence to precisely define the duration of the seizure; however, based on current evidence an operational threshold of 10 minutes is appropriate as beyond this a seizure is likely to be more prolonged. The individual may or may not be aware or in coma.
http://purl.obolibrary.org/obo/HP_0031480	Abnormal mitral valve leaflet morphology	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		Any structural anomaly of the leaflets (also known as cusps) of the mitral valve.
http://purl.obolibrary.org/obo/HP_0031508	Abnormal circulating thyroid hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal range of the hormones produced by the thyroid gland.
http://purl.obolibrary.org/obo/HP_0031546	Cardiac conduction abnormality	http://purl.obolibrary.org/obo/HP_0030956	Abnormality of cardiovascular system electrophysiology		Any anomaly of the progression of electrical impulses through the heart.
http://purl.obolibrary.org/obo/HP_0031566	Abnormal pulmonary valve cusp morphology	http://purl.obolibrary.org/obo/HP_0001641	Abnormal pulmonary valve morphology		Any structural anomaly of the pulmonary valve leaflets.
http://purl.obolibrary.org/obo/HP_0031909	Unicornuate uterus	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		A uterus that has a single horn, with a banana-like shape that may or may not have a secondary rudimentary uterine horn.
http://purl.obolibrary.org/obo/HP_0031912	Trigeminal anesthesia	http://purl.obolibrary.org/obo/HP_0031911	Abnormal fifth cranial nerve physiology		Decreased or absent sensation in the distribution of the trigeminal nerve, which provides tactile, proprioceptive, and nociceptive sensation in the area of the face and mouth.
http://purl.obolibrary.org/obo/HP_0031913	Rhombencephalosynapsis	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		Rhombencephalosynapsis is a rare brain malformation defined by midline fusion of the cerebellar hemispheres with partial or complete loss of the intervening vermis.
http://purl.obolibrary.org/obo/HP_0031914	Fluctuating	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Varying irregularly over time in severity, amount, or amplitude.
http://purl.obolibrary.org/obo/HP_0031915	Stable	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		This modifier can be applied to a phenotypic feature that does not vary in severity or amount over time.
http://purl.obolibrary.org/obo/HP_0031918	Ovarian sex cord-stromal tumor	http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm		A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts.
http://purl.obolibrary.org/obo/HP_0031919	Juvenile type ovarian granulosa cell tumor	http://purl.obolibrary.org/obo/HP_0031918	Ovarian sex cord-stromal tumor		Juvenile granulosa cell ovarian tumor (JGCOT) is a rare sex cord stromal tumor, occurring most frequently in premenarchal girls or young women. In contrast to adult granulosa cell tumor, JGCOT has a high mitotic index and more aggressive tumor growth. Microscopically it is seen as diffuse and regularly distributed neoplastic cells with a wide cytoplasm and pleomorphic hyperchromatic nucleus. Follicle formation, in various sizes and shapes, is important in JGCOT. Call-Exner bodies are infrequently seen in JGCOT in contrast to the adult type.
http://purl.obolibrary.org/obo/HP_0031920	Malignant ovarian granulosa cell tumor	http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm		An aggressive granulosa cell tumor that arises from the ovary.
http://purl.obolibrary.org/obo/HP_0031921	Gastrocnemius myalgia	http://purl.obolibrary.org/obo/HP_0003326	Myalgia		Pain of the gastrocnemius muscle.
http://purl.obolibrary.org/obo/HP_0031922	Renal artery duplication	http://purl.obolibrary.org/obo/HP_0008776	Abnormal renal artery morphology		The renal arteries carry blood from the aorta to the kidney; normally one renal artery is present on each side of the body. Renal artery duplication refers to the presence of two rather than one renal artery on a given side of the body.
http://purl.obolibrary.org/obo/HP_0031923	Hematocolpos	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		Accumulation of blood in the vagina usually due to vaginal obstruction.
http://purl.obolibrary.org/obo/HP_0031924	Rope sign	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		The presence of linear erythematous palpable cords, often on the lateral trunk.
http://purl.obolibrary.org/obo/HP_0031925	Rosette	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub.
http://purl.obolibrary.org/obo/HP_0031926	Homer Wright rosette	http://purl.obolibrary.org/obo/HP_0031925	Rosette		A type of rosette in which the central lumen or hub is filled with fiber-like processes.
http://purl.obolibrary.org/obo/HP_0031927	Flexner-Wintersteiner rosette	http://purl.obolibrary.org/obo/HP_0031925	Rosette		The tumor cells that form the Flexner-Wintersteiner rosette circumscribe a central lumen that contains small cytoplasmic extensions of the encircling cells; however, unlike the center of the Homer Wright rosette, the central lumen does not contain the fiber-rich neuropil.
http://purl.obolibrary.org/obo/HP_0031928	True ependymal rosette	http://purl.obolibrary.org/obo/HP_0031925	Rosette		A type of rosette in which a halo of cells surrounds an empty lumen.
http://purl.obolibrary.org/obo/HP_0031929	Perivascular pseudorosette	http://purl.obolibrary.org/obo/HP_0031925	Rosette		A type of rosette in which a spoke-wheel arrangement of cells with tapered cellular processes radiates around a wall of a centrally placed vessel.
http://purl.obolibrary.org/obo/HP_0031930	Neurocytic rosette	http://purl.obolibrary.org/obo/HP_0031925	Rosette		A type of rosette that is similar to the Homer Wright rosette, but the central fiber-rich neuropil island is larger and more irregular.
http://purl.obolibrary.org/obo/HP_0031931	Ocular flutter	http://purl.obolibrary.org/obo/HP_0032104	Saccadic oscillation		Ocular flutter is an abnormal eye movement consisting of repetitive, irregular, involuntary bursts of horizontal saccades without an intersaccadic interval. It is generally superimposed on normal oculomotor behavior and its occurrence may be favored by various events, such as blinks, the triggering of normal saccades or optokinetic stimulation.
http://purl.obolibrary.org/obo/HP_0031932	Aorto-left ventricular tunnel	http://purl.obolibrary.org/obo/HP_0011627	Aorto-ventricular tunnel		Aorto-left ventricular tunnel (ALVT) is a congenital extracardiac channel connecting the ascending aorta above the sino-tubular junction to either left or right ventricular cavity.
http://purl.obolibrary.org/obo/HP_0031933	Aorto-right ventricular tunnel	http://purl.obolibrary.org/obo/HP_0011627	Aorto-ventricular tunnel		The presence of an extracardiac channel that connects the ascending aorta above the sinotubular junction to the cavity of the right ventricle.
http://purl.obolibrary.org/obo/HP_0031934	Abnormal descending aorta morphology	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		A structural abnormality of the part of the aorta that begins at the aortic arch and then descends through the chest and abdomen.
http://purl.obolibrary.org/obo/HP_0031935	Ascending aorta hypoplasia	http://purl.obolibrary.org/obo/HP_0031784	Abnormal ascending aorta morphology		Significant luminal narrowing of a long segment of or the entire ascending aorta.
http://purl.obolibrary.org/obo/HP_0031936	Delayed ability to walk	http://purl.obolibrary.org/obo/HP_0002194	Delayed gross motor development		A failure to achieve the ability to walk at an appropriate developmental stage. Most children learn to walk in a series of stages, and learn to walk short distances independently between 12 and 15 months.
http://purl.obolibrary.org/obo/HP_0031937	Tachylalia	http://purl.obolibrary.org/obo/HP_5200011	Abnormal speech rate		Speech that is abnormally fast as compared to the perceived cultural norm.
http://purl.obolibrary.org/obo/HP_0031942	Congenital absence of portal vein	http://purl.obolibrary.org/obo/HP_0031941	Abnormal portal venous system morphology		Anomaly where the intestinal and the splenic venous drainage bypass the liver and drain into systemic veins through other possible venous shunts.
http://purl.obolibrary.org/obo/HP_0031943	Akathisia	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria.
http://purl.obolibrary.org/obo/HP_0031944	Pleural thickening	http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology		An increase in the thickness of the pleura, generally related to scarring of the pleural tissue.
http://purl.obolibrary.org/obo/HP_0031945	Elevated circulating N,N-dimethylglycine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An increased concentration of N,N-dimethylglycine in the circulation.
http://purl.obolibrary.org/obo/HP_0031946	Elevated urinary N,N-dimethylglycine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		An increased concentration of N,N-dimethylglycine in the urine.
http://purl.obolibrary.org/obo/HP_0031947	Tongue tremor	http://purl.obolibrary.org/obo/HP_0030188	Tremor by anatomical site		An unintentional, oscillating to-and-fro muscle movement affecting the tongue.
http://purl.obolibrary.org/obo/HP_0031948	Snowball lesion of corpus callosum	http://purl.obolibrary.org/obo/HP_0001273	Abnormal corpus callosum morphology		Centrally located corpus callosum hyperintensities said to resemble snowballs upon magnetic resonance imaging (with T2 or Sagittal fluid attenuated inversion recovery [FLAIR] sequences). The central location in the callosum makes them pathognomonic for Susac syndrome.
http://purl.obolibrary.org/obo/HP_0031949	Recurrent bacterial upper respiratory tract infections	http://purl.obolibrary.org/obo/HP_0002788	Recurrent upper respiratory tract infections		An increased susceptibility to bacterial upper respiratory tract infections as manifested by a history of recurrent bacterial upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).
http://purl.obolibrary.org/obo/HP_0031950	Usual interstitial pneumonia	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Temporal and spatial heterogeneity in lungs based on presence of fibrosis and honeycombing.
http://purl.obolibrary.org/obo/HP_0031951	Nocturnal seizures	http://purl.obolibrary.org/obo/HP_0001250	Seizure		Seizures that occur while the affected individual is sleeping.
http://purl.obolibrary.org/obo/HP_0031952	Neurogenic claudication	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Lumbar spinal stenoses may induce symptoms following an individually typical latency on standing or when walking due to swelling of the cauda equina, which leads to compression. This is referred to as neurogenic claudication. The symptoms of lumbar spinal stenosis can be explained by an increase in lumbar lordosis and spinal canal stenosis in an upright position compared to the sitting position or if spondylolisthesis is present by a shift of the vertebrae while standing and walking. Following an individually characteristic distance, walking becomes associated with deep muscular pain and with neurological deficits, such as sensory deficits and paresis in the lower limbs, which resolve within minutes when the affected person sits or lies down. Activities performed in a flexed posture, such as cycling often cause less problems than walking. For the same reason, walking uphill may be tolerated better than walking downhill. Clinical neurological examination at rest may be entirely normal but there is usually pain on hyperextension of the lumbar spine.
http://purl.obolibrary.org/obo/HP_0031953	Cautious gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Cautious gait refers to an excessive degree of age-related changes in walking and fear of falling. The walking difficulties seem out of proportion when considering the patient's actual sensory or motor deficits. The gait appears slow, with a wider base than normal, reduced arm swing bilaterally and a slightly stooped posture. This type of gait change often occurs after the first time a patient has fallen.
http://purl.obolibrary.org/obo/HP_0031954	Dystonic gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Dystonic gait disorders frequently appear bizarre, particularly because activity increases dystonic tonus and posture. The abnormal posture of the foot in dystonic gait typically involves inversion, plantar flexion and tonic extension of the big toe. In many patients complex types of walking, such as walking backwards and running are paradoxically less impaired than walking forward and may seem completely unaffected. Sensory tricks, for instance, if the affected individual rests a hand on his or her neck, may improve or even normalize dystonic gait in some patients.
http://purl.obolibrary.org/obo/HP_0031955	Antalgic gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		To avoid pain weight is put on the affected leg for as short a time as possible, resulting in a limp. The patients appear to be walking as if there were a thorn in the sole of the foot. To reduce the load on the affected leg the patients lift and lower their foot in a fixed ankle position.
http://purl.obolibrary.org/obo/HP_0031956	Elevated circulating aspartate aminotransferase concentration	http://purl.obolibrary.org/obo/HP_0002910	Elevated circulating hepatic transaminase concentration		The concentration of aspartate aminotransferase (AST) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031957	Spastic hemiparetic gait	http://purl.obolibrary.org/obo/HP_0002064	Spastic gait		Spastic hemiparesis is characterized by a dominance of the tonus in the upper limb flexor muscles: the arm is held in an adducted posture and is bent and rotated inwards, the forearm is pronated and the hand and the fingers are flexed. The leg is slightly bent at the hip, the knee cannot be extended fully at the end of the stance phase and the foot is inverted and in a plantar flexed position. Gait is slow, with a wide base and asymmetrical with a shortened weight-bearing phase on the paretic side. During the swing phase, the paretic leg performs a lateral movement (circumduction) which is characteristic of this gait disorder, also termed Wernicke-Mann gait. Spastic gait problems typically worsen on attempts to walk faster.
http://purl.obolibrary.org/obo/HP_0031958	Spastic paraparetic gait	http://purl.obolibrary.org/obo/HP_0002064	Spastic gait		A type of spastic gait in which the legs are usually slightly bent at the hip and in an adducted position. The knees are extended or slightly bent and the feet are in a plantar flexion position. This posture requires circumduction of the legs during walking. The gait may appear stiff (spastic gait disorder) or stiff as well as insecure (spastic ataxic gait disorder). In spastic paraparetic gait, each leg appears to be dragged forward. If the muscle tone in the adductors is marked, the resulting gait disorder is referred to as scissor gait.
http://purl.obolibrary.org/obo/HP_0031959	Leg dystonia	http://purl.obolibrary.org/obo/HP_0002451	Limb dystonia		A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the legs.
http://purl.obolibrary.org/obo/HP_0031960	Arm dystonia	http://purl.obolibrary.org/obo/HP_0002451	Limb dystonia		A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the arms.
http://purl.obolibrary.org/obo/HP_0031961	Abnormal serum anion gap	http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis		Any deviation from the normal value of the serum anion gap, which is calculated from the electrolytes measured in the chemical laboratory, is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration.
http://purl.obolibrary.org/obo/HP_0031962	Elevated serum anion gap	http://purl.obolibrary.org/obo/HP_0031961	Abnormal serum anion gap		An abnormally high value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration).
http://purl.obolibrary.org/obo/HP_0031963	Decreased serum anion gap	http://purl.obolibrary.org/obo/HP_0031961	Abnormal serum anion gap		An abnormally low value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration).
http://purl.obolibrary.org/obo/HP_0031964	Elevated circulating alanine aminotransferase concentration	http://purl.obolibrary.org/obo/HP_0002910	Elevated circulating hepatic transaminase concentration		An abnormally high concentration in the circulation of alanine aminotransferase (ALT).
http://purl.obolibrary.org/obo/HP_0031965	Increased RBC distribution width	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.
http://purl.obolibrary.org/obo/HP_0031967	Cloudy urine	http://purl.obolibrary.org/obo/HP_0033072	Abnormal macroscopic urine appearance		The appearance of the urine having visible material in suspension, i.e., appearing cloudy.
http://purl.obolibrary.org/obo/HP_0031969	Reduced blood urea nitrogen	http://purl.obolibrary.org/obo/HP_0031970	Abnormal blood urea nitrogen concentration		An abnormally low concentration of urea nitrogen in the blood.
http://purl.obolibrary.org/obo/HP_0031971	Subaortic ventricular septal bulge	http://purl.obolibrary.org/obo/HP_0011103	Abnormal left ventricular outflow tract morphology		A localized hypertrophy of the subaortic segment of the ventricular septum has been frequently described in elderly persons, and variously termed subaortic ventricular septal bulge (VSB), sigmoid-shaped septum, localized or discrete upper septal hypertrophy.
http://purl.obolibrary.org/obo/HP_0031972	Presyncope	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause.
http://purl.obolibrary.org/obo/HP_0031973	Increased vertical cup-to-disc ratio	http://purl.obolibrary.org/obo/HP_0012796	Increased cup-to-disc ratio		An abnormal increase in the ratio of the height of the cup of the optic nerve head to the height of the disk.
http://purl.obolibrary.org/obo/HP_0031974	Increased vertical cup-to-disc ratio - 0.6	http://purl.obolibrary.org/obo/HP_0031973	Increased vertical cup-to-disc ratio		Ratio of the height of the cup of the optic nerve head to the height of the disk is 0.6 (The normal cup-to-disc ratio is 0.3).
http://purl.obolibrary.org/obo/HP_0031975	Increased vertical cup-to-disc ratio - 0.7	http://purl.obolibrary.org/obo/HP_0031973	Increased vertical cup-to-disc ratio		Ratio of the height of the cup of the optic nerve head to the height of the disk is 0.7 (The normal cup-to-disc ratio is 0.3).
http://purl.obolibrary.org/obo/HP_0031976	Increased vertical cup-to-disc ratio - 0.8	http://purl.obolibrary.org/obo/HP_0031973	Increased vertical cup-to-disc ratio		Ratio of the height of the cup of the optic nerve head to the height of the disk is 0.8 (The normal cup-to-disc ratio is 0.3).
http://purl.obolibrary.org/obo/HP_0031977	Increased vertical cup-to-disc ratio - 0.9	http://purl.obolibrary.org/obo/HP_0031973	Increased vertical cup-to-disc ratio		Ratio of the height of the cup of the optic nerve head to the height of the disk is 0.9 (The normal cup-to-disc ratio is 0.3).
http://purl.obolibrary.org/obo/HP_0031978	Increased vertical cup-to-disc ratio - 1.0	http://purl.obolibrary.org/obo/HP_0031973	Increased vertical cup-to-disc ratio		Ratio of the height of the cup of the optic nerve head to the height of the disk is 1.0 (The normal cup-to-disc ratio is 0.3).
http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Any deviation from the normal concentration of a carbohydrate in the urine.
http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Any deviation from the normal concentration of a carboxylic acid in the urine.
http://purl.obolibrary.org/obo/HP_0031981	Elevated urine glycolate	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		An increased concentration of glycolate in the urine.
http://purl.obolibrary.org/obo/HP_0031982	Abnormal putamen morphology	http://purl.obolibrary.org/obo/HP_0010994	Abnormal corpus striatum morphology		Any structural anomaly of the putamen, a brain nucleus which together with the caudate nucleus and fundus striati makes up the striatum.
http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding	http://purl.obolibrary.org/obo/HP_0012252	Abnormal respiratory system morphology		This term groups terms representing abnormal findings derived from chest X-ray investigation of the lung. In general, lung abnormalities can manifest as opacities (areas of increased density) or as regions with decreased density.
http://purl.obolibrary.org/obo/HP_0031984	Esophageal food impaction	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		A piece of food that has gotten stuck in the esophagus and prevents further swallowing.
http://purl.obolibrary.org/obo/HP_0031985	Esophageal exudate	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		An exudate is a mass of fluid and cells that has seeped out of blood vessels or an organ, usually related to inflammation. In the esophagus, exudates usually present as whitish plagues on the surface of the esophageal mucosa.
http://purl.obolibrary.org/obo/HP_0031986	Polyminimyoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		Minipolymyoclonus or polyminimyoclonus is a hyperkinetic movement disorder phenomenology characterized by intermittent, low-amplitude, arrhythmic movements of the hands, commonly of several fingers, with amplitudes just sufficient to produce visible and palpable movements of the joints. It is mostly noticed while the individual is maintaining a posture (commonly outstretched hands) or during action (especially the initial phase of movement).
http://purl.obolibrary.org/obo/HP_0031987	Diminished ability to concentrate	http://purl.obolibrary.org/obo/HP_5200044	Reduced attention regulation		The inability to focus or concentrate on a specific task, activity, or object. The subject may find themselves unable to grasp or understand written text and re-reads frequently without understanding. Familiar tasks or activities are severely compromised due to the lack of ability to concentrate. Thinking through multi-step problems is typically very difficult or impossible, leading to avoidance of such activities.
http://purl.obolibrary.org/obo/HP_0031989	Perioral spasm	http://purl.obolibrary.org/obo/HP_0003394	Muscle spasm		A sudden involuntary contraction of the musculature surrounding the mouth.
http://purl.obolibrary.org/obo/HP_0031990	Chvostek sign	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		A contraction of ipsilateral facial muscles subsequent to percussion over the facial nerve.
http://purl.obolibrary.org/obo/HP_0031991	Increased urinary excretion of galactosyl hydroxylysine	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An increased concentration of beta-1-galactosyl-O-hydroxylysine (Gal-Hyl) in the urine. This is a biochemical marker of bone resorption.
http://purl.obolibrary.org/obo/HP_0031992	Apical hypertrophic cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001639	Hypertrophic cardiomyopathy		Apical hypertrophic cardiomyopathy (AHCM) is diastolic dysfunction due to abnormal stiffness of the left ventricle during diastole, with resultant impaired ventricular filling. In AHCM thickened apical segments produce a crowded, spade-shaped, small apical cavity.
http://purl.obolibrary.org/obo/HP_0031993	Hoffmann sign	http://purl.obolibrary.org/obo/HP_0007256	Abnormal pyramidal sign		A Hoffmann test is performed by flicking the fingernail of the long finger, from dorsal to volar, on each hand while the hand was supported by the examiner's hand. The test was done with the neck in the neutral position and then with the neck maximally forward flexed. Any flexion of the ipsilateral thumb and/or index finger was interpreted as a positive test.
http://purl.obolibrary.org/obo/HP_0031994	Bronchial breath sound	http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound		Bronchial breath sounds contain much higher frequency components than normal breath sounds due to alteration of the low pass filtering function of the alveoli, as occurs in consolidation. It is loud, hollow, and high pitch. Expiratory phase is longer than inspiratory phase with the inspiratory-expiratory ratio (I:E) changing from normal 3:1 to 1:2. There is distinct pause between inspiration and expiration due to absent alveolar phase. It is associated with whispering pectoriloquy.
http://purl.obolibrary.org/obo/HP_0031995	Squawks	http://purl.obolibrary.org/obo/HP_0030828	Wheezing		Squawks are short inspiratory wheezes of less than 200 ms duration and are also known as squeaks. Acoustic analysis shows the fundamental frequency varying between 200 and 300 Hz. Squawks usually occur in late inspiration and are often preceded by late inspiratory crackles.
http://purl.obolibrary.org/obo/HP_0031996	Inspiratory crackles	http://purl.obolibrary.org/obo/HP_0030830	Crackles		Crackles that are heard during the inspiratory phase.
http://purl.obolibrary.org/obo/HP_0031997	Early inspiratory crackles	http://purl.obolibrary.org/obo/HP_0031996	Inspiratory crackles		Crackles that appear at the beginning of inspiration and end before mid-inspiration.
http://purl.obolibrary.org/obo/HP_0031998	Late inspiratory crackles	http://purl.obolibrary.org/obo/HP_0031996	Inspiratory crackles		Crackles that appear any time after the beginning of inspiration and last till the end of inspiration.
http://purl.obolibrary.org/obo/HP_0031999	Expiratory crackles	http://purl.obolibrary.org/obo/HP_0030830	Crackles		Crackles that occur during expiration.
http://purl.obolibrary.org/obo/HP_0032000	Pleural rub	http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound		An abnormal breath sound that is nonmusical, short and explosive. It is grating, rubbing, creaky, or leathery in character and present in both phases of respiration. Typically the expiratory component mirrors the inspiratory component. It occurs due to inflamed pleural surface rubbing each other during breathing. Clinically, it is important to differentiate it from crackles
http://purl.obolibrary.org/obo/HP_0032001	Pink urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal pink color of urine.
http://purl.obolibrary.org/obo/HP_0032002	Orange urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal orange color of urine.
http://purl.obolibrary.org/obo/HP_0032003	Green urine	http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color		An abnormal green color of urine.
http://purl.obolibrary.org/obo/HP_0032004	Pruritus vulvae	http://purl.obolibrary.org/obo/HP_0000989	Pruritus		A sensation of itching in the vulvar region.
http://purl.obolibrary.org/obo/HP_0032005	Hemidystonia	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		Hemidystonia refers to dystonia which involves the ipsilateral face, arm, and leg.
http://purl.obolibrary.org/obo/HP_0032006	Lip tremor	http://purl.obolibrary.org/obo/HP_0030188	Tremor by anatomical site		An unintentional, oscillating to-and-fro muscle movement affecting the lip.
http://purl.obolibrary.org/obo/HP_0032007	Maceration	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		A softening and breaking down of skin resulting from prolonged exposure to moisture. Macerated skin becomes soft and wrinkly and takes on a whitish hue.
http://purl.obolibrary.org/obo/HP_0032008	Pulmonary fat embolism	http://purl.obolibrary.org/obo/HP_0002204	Pulmonary embolism		The release of fat globules into the venous circulation, thereby blocking blood circulation to the lung.
http://purl.obolibrary.org/obo/HP_0032009	Infantile constant exotropia	http://purl.obolibrary.org/obo/HP_0031713	Constant exotropia		Constant exotropia occurring before 6 months of age.; often associated with a large angle of deviation and ocular/CNS abnormalities.
http://purl.obolibrary.org/obo/HP_0032010	Basic constant exotropia	http://purl.obolibrary.org/obo/HP_0031713	Constant exotropia		Constant exotropia for near and distance, presenting after 6 months of age.
http://purl.obolibrary.org/obo/HP_0032011	Heterophoria	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		Heterophorias are latent deviations that are controlled by fusion. In certain circumstances (specific visual tasks, fatigue, illness, etc.), fusion can no longer be maintained and decompensation occurs.
http://purl.obolibrary.org/obo/HP_0032013	Hypermetric horizontal saccades	http://purl.obolibrary.org/obo/HP_0007338	Hypermetric saccades		Overshoot of horizontal (sideways) saccadic eye movements.
http://purl.obolibrary.org/obo/HP_0032014	Dysmetric vertical saccades	http://purl.obolibrary.org/obo/HP_0000641	Dysmetric saccades		Inaccurate saccades (rapid movement of the eye between fixation points) in the vertical direction.
http://purl.obolibrary.org/obo/HP_0032015	Dysmetric horizontal saccades	http://purl.obolibrary.org/obo/HP_0000641	Dysmetric saccades		Inaccurate saccades (rapid movement of the eye between fixation points) in the horizontal direction.
http://purl.obolibrary.org/obo/HP_0410199	Increased CSF urate concentration	http://purl.obolibrary.org/obo/HP_0500117	Abnormal CSF urate concentration		Increased concentration of urate in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0410200	Positive meconium barbiturate test	http://purl.obolibrary.org/obo/HP_0500098	Meconium xenobiotic		Detection of barbiturate metabolites such as phenobarbital in meconium.
http://purl.obolibrary.org/obo/HP_0410201	Positive hair barbiturate test	http://purl.obolibrary.org/obo/HP_0500099	Hair xenobiotic		Detection of barbiturate metabolites such as phenobarbital in the hair.
http://purl.obolibrary.org/obo/HP_0410202	Positive stool barbiturate test	http://purl.obolibrary.org/obo/HP_0500097	Stool xenobiotic		Detection of barbiturate metabolites such as phenobarbital in the stool.
http://purl.obolibrary.org/obo/HP_0410203	Positive gastric fluid barbiturate test	http://purl.obolibrary.org/obo/HP_0500101	Gastric fluid xenobiotic		Detection of barbiturate metabolites such as phenobarbital in the gastric fluid.
http://purl.obolibrary.org/obo/HP_0500104	Decreased diastolic blood pressure	http://purl.obolibrary.org/obo/HP_0002615	Hypotension		Abnormal decrease in diastolic blood pressure.
http://purl.obolibrary.org/obo/HP_0500105	Decreased systolic blood pressure	http://purl.obolibrary.org/obo/HP_0002615	Hypotension		Abnormal decrease in systolic blood pressure.
http://purl.obolibrary.org/obo/HP_0500106	Isolated systolic hypertension	http://purl.obolibrary.org/obo/HP_0004421	Elevated systolic blood pressure		Elevated systolic blood pressure without an elevated blood pressure.
http://purl.obolibrary.org/obo/HP_0500107	Isolated diastolic hypotension	http://purl.obolibrary.org/obo/HP_0500104	Decreased diastolic blood pressure		A decrease in diastolic blood pressure (<60 mmHg) without a decrease in systolic blood pressure (> or = to 100 mmHg).
http://purl.obolibrary.org/obo/HP_0500108	Positive urine cocaine test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of cocaine or its major metabolite, benzoylecgonine, in urine.
http://purl.obolibrary.org/obo/HP_0500109	Positive urine barbiturate test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of barbiturate metabolites such as Phenobarbital in urine.
http://purl.obolibrary.org/obo/HP_0500110	Positive urine cannabinoid test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of delta-9-tetrahydrocannabinol (THC) or other cannabinoid metabolites in urine.
http://purl.obolibrary.org/obo/HP_0500111	Positive urine benzodiazepines test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of benzodiazepine metabolites, primarily nordiazepam, oxazepam, and temazepam, in urine.
http://purl.obolibrary.org/obo/HP_0500112	Positive urine amphetamine test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of amphetamine or its metabolites in urine.
http://purl.obolibrary.org/obo/HP_0500113	Positive urine opioid test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of opioids or opioid metabolites in urine.
http://purl.obolibrary.org/obo/HP_0500114	Abnormal stool urobilinogen concentration	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Abnormal concentration of urobilinogen present in the stool.
http://purl.obolibrary.org/obo/HP_0500115	Increased stool urobilinogen concentration	http://purl.obolibrary.org/obo/HP_0500114	Abnormal stool urobilinogen concentration		An increased amount of urobilinogen present in the stool.
http://purl.obolibrary.org/obo/HP_0500116	Positive blood barbiturate test	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Detection of barbiturate metabolites such as Phenobarbital in blood.
http://purl.obolibrary.org/obo/HP_0500117	Abnormal CSF urate concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Abnormal concentration of urate in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/UBERON_4300226	forelimb bud mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010328	limb bud mesenchyme		Mesenchyme that is part of a forelimb bud.
http://purl.obolibrary.org/obo/UBERON_4300227	hindlimb bud mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010328	limb bud mesenchyme		Mesenchyme that is part of a hindlimb bud.
http://purl.obolibrary.org/obo/PR_000050060	glucose-6-phosphate dehydrogenase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that contains a single copy of the Glucose-6-phosphate dehydrogenase, NAD binding domain (Pfam:PF00479) at or near the N terminus, a single copy of the Glucose-6-phosphate dehydrogenase, C-terminal domain (Pfam:PF02781) at or near the C terminus, and no other domains.
http://purl.obolibrary.org/obo/HP_0020221	Clonic seizure	http://purl.obolibrary.org/obo/HP_0020219	Motor seizure		A clonic seizure is a type of motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.
http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Any structural anomaly of the interstitium of the kidney. The renal interstitium is defined as the intertubular, extraglomerular, extravascular space of the kidney. It is bounded on all sides by tubular and vascular basement membranes and is filled with cells, extracellular matrix, and interstitial fluid.
http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Any structural anomaly of the renal tubular epithelial cells (RTEC), a layer of cells in the outer layer of the renal tubule. These cells play a role in the absorption of substances such as glucose and amino from the primary urine.
http://purl.obolibrary.org/obo/CL_0011025	exhausted T cell	http://purl.obolibrary.org/obo/CL_0000911	effector T cell		An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential.
http://purl.obolibrary.org/obo/HP_0033668	Abnormal amygdala morphology	http://purl.obolibrary.org/obo/HP_0007343	Abnormal morphology of the limbic system		A structural anomaly of the amygdala.
http://purl.obolibrary.org/obo/HsapDv_0010000	postnatal stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Human developmental stage that covers the whole of human life post birth.
http://purl.obolibrary.org/obo/HP_0034241	Prenatal death	http://purl.obolibrary.org/obo/HP_0011420	Age of death		Death of a fetus in the uterus.
http://purl.obolibrary.org/obo/UBERON_8410079	red bone marrow of iliac crest	http://purl.obolibrary.org/obo/UBERON_0000361	red bone marrow		Red bone marrow located in an iliac crest.
http://purl.obolibrary.org/obo/UBERON_8410080	red bone marrow of sternum	http://purl.obolibrary.org/obo/UBERON_0000361	red bone marrow		Red bone marrow located in the sternum.
http://purl.obolibrary.org/obo/UBERON_8440015	noradrenergic cell groups	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin).
http://purl.obolibrary.org/obo/UBERON_8470001	sublumbar lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node with a lymph center located within the caudal abdomen and pelvis, on the ventral side of the lumbar region. Includes the medial iliac, internal iliac (previously termed hypogastric) and sacral lymph nodes.
http://purl.obolibrary.org/obo/CL_4033064	uterine resident macrophage	http://purl.obolibrary.org/obo/CL_0000864	tissue-resident macrophage		A tissue-resident macrophage that is part of the uterus.
http://purl.obolibrary.org/obo/HP_6000705	Thickened fibular cortex	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		Abnormal increase in the thickness (distance between the inner and outer boundaries) of the outer layer (cortex) of the fibula.
http://purl.obolibrary.org/obo/HP_6000706	New medication added in recent weeks	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of starting a new medication recently.
http://purl.obolibrary.org/obo/HP_6000707	Noctural pain	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Pain at night.
http://purl.obolibrary.org/obo/HP_6000708	Femoral osteosclerosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		An abnormal increase of bone mineral density of the femur. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_6000709	Absent Bell phenomenon	http://purl.obolibrary.org/obo/HP_0012547	Abnormal involuntary eye movements		The Bell phenomenon is the reflex upward movement of the front of the eyeball when the eyelids close (or blink). It protects the eye by helping to keep the cornea moist. This term refers to a lack of this phenomenon, which can be observed with certain conditions such as congenital fibrosis of the extraocular muscles.
http://purl.obolibrary.org/obo/HP_6000710	Dalen-Fuchs nodules	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Nodules (yellow-white subretinal pigment epithelium lesions) that form between Bruch membrane and the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_6000711	Triggering by ocular trauma	http://purl.obolibrary.org/obo/HP_0031135	Triggered by physical trauma		Applies to a sign or symptom that is provoked or brought about by trauma to the eye.
http://purl.obolibrary.org/obo/HP_6000712	Gelatinous drop-like dystrophic cornea	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		Deposition of amyloid material in the subepithelial space of the cornea.
http://purl.obolibrary.org/obo/HP_6000713	Hepatic reticuloendothelial system cell iron deposition	http://purl.obolibrary.org/obo/HP_0040134	Abnormal hepatic iron concentration		Abnormal accumulation of iron in reticuloendothelial cells of the liver. This feature can be appreciated on liver biopsy by Perls iron stain for granular iron deposition, based on agreement that only discernible hemosiderin granules represent significant iron deposition.
http://purl.obolibrary.org/obo/HP_6000714	Reduced epidermal kindlin-1 expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		Lower than normal amount of kindlin-1 in the epidermis.
http://purl.obolibrary.org/obo/HP_6000715	Central giant cell lesion of the jaw	http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology		A benign proliferative and asymptomatic intraosseous lesion of the jaw formed by fibrous tissue that contains multiple focus of hemorrhage and an aggregation of multinucleated giant cells.
http://purl.obolibrary.org/obo/HP_6000716	Terminal hepatic lobular vascular occlusion	http://purl.obolibrary.org/obo/HP_0006707	Abnormality of the hepatic vasculature		A type of Hepatic venous outflow obstruction characterized by fibrous concentric narrowing of zone 3 terminal hepatic venules, centrilobular hepatocyte necrosis, and sinusoidal congestion, accomapnied by necrosis of pericentral hepatocytes, and narrowing and eventual fibrosis of central veins.
http://purl.obolibrary.org/obo/HP_6000717	Axonal spheroids	http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology		During neurodegeneration, bubble-like swellings form along the length of the axon, a primary and early effect of dynamic axonal deformation. These varicosities, spheroids, or swellings have been described as beads on a string and branches bearing fruit, and they frequently appear on degenerating axons.
http://purl.obolibrary.org/obo/HP_6000718	Decreased liver bile salt export pump expression	http://purl.obolibrary.org/obo/HP_0034644	Abnormal liver metabolite concentration		Amount of bile salt export pump (BSEP, coded by the ABCB11 gene) in liver tissue below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000719	Reduced tissue type II iodothyronine deiodinase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of type II iodothyronine deiodinase below the lower limit of normal. The activity can be measured in tissues such as cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000720	Reduced tissue fatty aldehyde dehydrogenase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of fatty aldehyde dehydrogenase (EC 1.2.1.3) in tissues below the lower limit of normal. The activity can be measured in multiple tissues including culutured fibroblasts and leukocytes.
http://purl.obolibrary.org/obo/HP_6000721	Decreased circulating pancreatic isoamylase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of alpha-Amylase (1,4-alpha-D-glucan-4-glucanohydrolase E. C. 3.2.1.1, pancreatic isoamylase) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000722	Reduced tissue guanidinoacetate methyltransferase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of the mitochondrial enzyme guanidinoacetate methyltransferase in tissues below the lower limit of normal. The activity can be measured in multiple tissues including culutured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000723	Reduced erythrocyte galactokinase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of in the level of galactokinase (EC 2.7.1.6) in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000724	Auspitz sign	http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology		The appearance of small bleeding points after successive layers of scale have been removed from the surface of psoriatic papules or plaques.
http://purl.obolibrary.org/obo/HP_6000725	Salty tasting skin	http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology		Skin tastes marked salty without an obvious explanation such as heat or exercise. This finding can be observed in infants with cystic fibrosis.
http://purl.obolibrary.org/obo/HP_6000726	Scalp nodule	http://purl.obolibrary.org/obo/HP_0001965	Abnormal scalp morphology		A small firm lump located in the skin of the scalp that is greater than one cm in diameter.
http://purl.obolibrary.org/obo/HP_6000727	History of undercooked pork ingestion	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A history of ingestion of undercooked pork. This is particularly relevant in areas with a high prevalence of cysticercosis.
http://purl.obolibrary.org/obo/HP_6000728	History of recent rodent exposure	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A history of exposed to rodents (mice, rats, prarie dogs) within several weeks of the current presenting complaint.
http://purl.obolibrary.org/obo/HP_6000729	Positive CSF fungus test	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		Any kind of test for a fungal infectious agent in the cerebrospinal fluid (CSF) positive.
http://purl.obolibrary.org/obo/HP_6000730	Positive CSF human T-lymphotropic virus type I antibody positivity	http://purl.obolibrary.org/obo/HP_0430139	CSF pathogen-specific antibody positivity		The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of human T-lymphotropic virus type I.
http://purl.obolibrary.org/obo/HP_6000731	Positive chlamydia trachomatis urine nucleic acid test	http://purl.obolibrary.org/obo/HP_0034889	Positive urine infectious agent nucleic acid test		Detection of Chlamydia trachomatis nucleic acid in the urine by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000732	Anti-streptococcus deoxyribonuclease-B antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against streptococcal deoxyribonuclease-B (ADN-B). Almost all group A streptococci have this antigen and a strong elevation of the antibody is observed in patients with acute rheumatic fever, acute glomerulonephritis and other streptococcal infections.
http://purl.obolibrary.org/obo/HP_6000733	Positive streptococcus A rapid antigen detection test	http://purl.obolibrary.org/obo/HP_6000579	Positive oropharangeal infectious agent test		Positive detection of a group A streptococcal antigen in a test perforned on a throat swab.
http://purl.obolibrary.org/obo/HP_6000734	Positive synovial mycobacterial culture	http://purl.obolibrary.org/obo/HP_6000582	Positive synonvial fluid culture		Growth of a mycobacteria in a culture derived from synovial fluid.
http://purl.obolibrary.org/obo/HP_6000735	Positive mycobacterial synovial nucleic acid test	http://purl.obolibrary.org/obo/HP_6000581	Positive synonvial fluid infectious agent test		Detection of nucleic acid of mycobacteria in the synovial fluid by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000736	Positive bloodstream babesia nucleic acid pathogen test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of genus Babesia (parasite) in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000737	Positive bloodstream influenza nucleic test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of an influenza virus in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000738	Positive bloodstream parainfluenza virus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of parainfluenza virus in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000739	Positive bloodstream adenovirus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of an adenovirus in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000740	Anti-Francisella tularensis antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against a component of Francisella tularensis.
http://purl.obolibrary.org/obo/HP_6000741	Positive bloodstream MERS coronavirus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000742	Positive nasopharyngeal corynebacterium diphtheriae nucleic acid test	http://purl.obolibrary.org/obo/HP_6000579	Positive oropharangeal infectious agent test		Detection of nucleic acid of Corynebacterium diphtheriae in nasopharyngeal secretions by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000743	Pediculosis capitis	http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test		Visualization of at least one louse on visual inspection of the head hair. Use of a bright light, magnifying lens, or fine-toothed comb (lice comb) can aid in diagnosis.
http://purl.obolibrary.org/obo/HP_6000744	Premature glabellar skin wrinkling	http://purl.obolibrary.org/obo/HP_0100678	Premature skin wrinkling		The presence in the skin of the glabellar region of an increased degree of wrinkling (irregular folds and indentations) of the skin as compared with age-related norms.
http://purl.obolibrary.org/obo/HP_6000745	Flexural reticulate hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007427	Reticulated skin pigmentation		Hyperpigmented macules with a reticulate (net-like) pattern involving the neck, axillae, groins, and other flexures like the inframammary folds in females. Histopathology shows orthokeratosis or hyperkeratosis, thinning of the suprapapillary epithelium, elongation of the rete ridges, hyperpigmentation of the basal layer, and follicular cysts. A perivascular lymphohistiocytic infiltrate can be observed in the papillary dermis.
http://purl.obolibrary.org/obo/HP_6000746	Elevated fractional excretion of urate	http://purl.obolibrary.org/obo/HP_0011036	Abnormality of renal excretion		Abnormally increased proportion of filtered urate that is excreted in the urine as calculated using the concentrations of urate and creatinine in both blood and urine. Clinically this manifests as uric acid wasting.
http://purl.obolibrary.org/obo/HP_6000747	Abnormal urinary creatine level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		The amount of creatine in the urine, normalized for urine concentration, is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_6000748	Decreased urinary creatine level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		The amount of creatine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000749	Elevated circulating PINP concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of PINP (= aminoterminal propeptide of type I procollagen) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000750	Decreased tissue S-adenosylhomocysteine hydrolase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of S-adenosylhomocysteine hydrolase (EC 3.3.1.1) below the lower limit of normal. FECH enzyme can be measured in multiple tissues including erythrocytes and liver.
http://purl.obolibrary.org/obo/HP_6000751	Decreased urinary dopamine level	http://purl.obolibrary.org/obo/HP_0045012	Decreased urinary catecholamine concentration		The concentration of dopamine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000752	Elevated erythrocyte AICA-ribotide concentration	http://purl.obolibrary.org/obo/HP_0034737	Abnormal erythrocyte metabolite concentration		Concentration of 5-amino-4-imidazolecarboxamide (AICA-riboside) in red blood cells is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000753	Elevated circulating monomethyl sterol concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		Concentration of monomethylsterols (such as 4alpha-monomethylsterol) in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000754	Elevated circulating dimethyl sterol concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		The concentration of dimethylsterols in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000755	Elevated circulating C-terminal fibroblast growth factor 23 concentration	http://purl.obolibrary.org/obo/HP_6000489	Abnormal circulating fibroblast growth factor 23 concentration		The concentration of the C-terminal portion of fibroblast growth factor 23 in the blood circulation is outside of the limits of normal.
http://purl.obolibrary.org/obo/HP_6000756	Elevated urinary 5-hydroxyindoleacetic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of 5-hydroxyindoleacetic acid (5-HIAA) in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000757	Elevated circulating thiosulfate concentration	http://purl.obolibrary.org/obo/HP_0020330	Abnormal circulating inorganic anion concentration		The concentration of thiosulfate in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000758	Elevated circulating interleukin 1 receptor antagonist concentration	http://purl.obolibrary.org/obo/HP_0011111	Abnormal immune serum protein physiology		The concentration of interleukin 1 receptor antagonist (IL-1RA) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000759	Positive CSF West Nile virus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of West Nile virus nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000760	Positive CSF herpes simplex virus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of herpes simplex virus (HSV) nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000761	Positive CSF cryptococcal antigen test	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		A test result demonstrating the presence of a cryptococal antigen in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_6000762	Positive rubella CSF culture	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		Growth of rubella virus in a culture derived from cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_6000763	Positive CSF treponema pallidum nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of Treponema pallidum (syphillis) nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000764	Decreased CSF tetrahydrobiopterin level	http://purl.obolibrary.org/obo/HP_0040207	Abnormal CSF pterin concentration		Concentration of tetrahydrobiopterin in the cerebrospinal fluid (CSF) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000765	Decreased CSF N-acetyl-aspartyl-glutamate concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		The concentration of N-acetyl-aspartyl-glutamate (NAAG) in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000766	Positive CSF Tropheryma whipplei bacteria microscopy	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		Demonstration of Tropheryma whipplei bacteria in the cerebrospinal fluid (CSF) my microscopic analysis.
http://purl.obolibrary.org/obo/HP_6000767	CSF treponemal antibody positivity	http://purl.obolibrary.org/obo/HP_0430139	CSF pathogen-specific antibody positivity		The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of treponema pallidum (syphilis).
http://purl.obolibrary.org/obo/HP_6000768	Echophenomenon	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		A stimulus triggered repetition of an action (echopraxia) or sound (echolalia) performed without the explicit awareness of an individual.
http://purl.obolibrary.org/obo/HP_6000769	Paracentral hyper-autofluorecence	http://purl.obolibrary.org/obo/HP_0030602	Abnormal fundus autofluorescence imaging		Increased autofluorescence in areas adjacent to the central macula (but not including the very center).
http://purl.obolibrary.org/obo/HP_6000770	Fixed fetal extremities	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		A condition in which the limbs of a fetus are immobile or held in a rigid position. The limbs are consistently immobile and rigid. Fixed extremities can be observed during prenatal imaging (e.g., ultrasound).
http://purl.obolibrary.org/obo/HP_6000771	Abnormal peripapillary microvascular network	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		The density of the deep peripapillary microvascular network (i.e., the number of blood vessels) is below the lower limit of normal. This finding is observable by optical coherence tomography angiography.
http://purl.obolibrary.org/obo/HP_6000772	Auriculitis	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Inflammation of the skin and soft tissues of the outer ear.
http://purl.obolibrary.org/obo/HP_6000773	Recent history of moisture in external ear canal	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A recent history of being exposed to moisture in the external ear canal.
http://purl.obolibrary.org/obo/HP_6000774	History of recent trauma to external ear canal	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of trauma to the external ear canal, including cotton-swab use, in recent weeks.
http://purl.obolibrary.org/obo/HP_6000775	Elevated urinary 4-tyramine level	http://purl.obolibrary.org/obo/HP_0040416	Abnormal urinary nitrogen compound level		The amount of 4-tyramine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000776	Elevated circulating 3-hydroxykynurenine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		The concentration of 3-hydroxykynurenine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000777	Posterior vertebral body notching	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Exaggerated posterior vertebral notches.
http://purl.obolibrary.org/obo/HP_6000778	Cone-shaped distal tibial epiphysis	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The distal epiphysis (rounded portion of bone at the far end of the tibia distal to the growth plate) has an abnormal cone-shaped appearance, that is, the epiphysis has a globular form at the bottom, tapering to a point at the top.
http://purl.obolibrary.org/obo/HP_6000779	Osteoporotic femoral neck	http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology		Low bone mass localized in the neck of the femur. Osteoporosis is defined based on a T-score of -2.5 or lower (bone mineral density of 2.5 or more standard deviations below that of a normal young adult).
http://purl.obolibrary.org/obo/HP_6000780	Olanzapine exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken olanzapine.
http://purl.obolibrary.org/obo/HP_6000781	Reduced tissue phosphomannomutase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of the enzyme phosphomannomutase (EC 5.4.2.8) in tissues below the lower limit of normal. The activity can be measured in multiple tissues including leukocytes, fibroblasts, and liver.
http://purl.obolibrary.org/obo/HP_6000782	Reduced tissue phosphomannose isomerase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of the mitochondrial enzyme phosphomannose isomerase (PMI; EC 5.3.1.8) in tissues below the lower limit of normal. The activity can be measured in multiple tissues including leukocytes, fibroblasts, and liver.
http://purl.obolibrary.org/obo/HP_6000783	Reduced tissue palmitoyl-protein thioesterase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of the enzyme palmitoyl-protein thioesterase (PPT; EC 3.1.2.22) in tissues below the lower limit of normal. The activity can be measured in multiple tissues including culutured fibroblasts and leukocytes.
http://purl.obolibrary.org/obo/HP_6000784	Maternal household cat exposure	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		The mother of a fetus or index patient has a history of regular exposure to one or more cats, e.g., in the household.
http://purl.obolibrary.org/obo/HP_6000785	Protein craving	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		Unusually strong preference for protein-rich foods.
http://purl.obolibrary.org/obo/CL_4052002	syncytial cell	http://purl.obolibrary.org/obo/CL_0000228	multinucleate cell		A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm.
http://purl.obolibrary.org/obo/CL_4052003	intestinal villus capillary endothelial cell	http://purl.obolibrary.org/obo/CL_0002144	capillary endothelial cell		A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier.
http://purl.obolibrary.org/obo/CL_4052006	intestinal enteroendocrine progenitor	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs.
http://purl.obolibrary.org/obo/CL_0008060	GABA-Glut neuron	http://purl.obolibrary.org/obo/CL_0000679	glutamatergic neuron		A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters.
http://purl.obolibrary.org/obo/CL_0000388	tendon cell	http://purl.obolibrary.org/obo/CL_1000307	fibroblast of dense regular elastic tissue		An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance.
http://purl.obolibrary.org/obo/UBERON_0000310	breast	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		The upper ventral region of the torso of an organism.
http://purl.obolibrary.org/obo/UBERON_0006247	iliac pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015054	iliac endochondral element		An iliac endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/PATO_0000004	mobility	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality of inhering in a bearer by virtue of the bearer's disposition to move freely.
http://purl.obolibrary.org/obo/PATO_0000014	color	http://purl.obolibrary.org/obo/PATO_0001300	optical quality		A composite chromatic quality composed of hue, saturation and intensity parts.
http://purl.obolibrary.org/obo/PATO_0000016	color brightness	http://purl.obolibrary.org/obo/PATO_0001300	optical quality		A scalar optical property that is the intensity, value or amount of perceived light.
http://purl.obolibrary.org/obo/PATO_0000017	color saturation	http://purl.obolibrary.org/obo/PATO_0001301	chromatic property		A scalar chromatic property that is the degree of purity of perceived light.
http://purl.obolibrary.org/obo/PATO_0000025	composition	http://purl.obolibrary.org/obo/PATO_0000141	structure		A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts.
http://purl.obolibrary.org/obo/PATO_0000033	concentration of	http://purl.obolibrary.org/obo/PATO_0000070	amount		A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance.
http://purl.obolibrary.org/obo/PATO_0000044	frequency	http://purl.obolibrary.org/obo/PATO_0050000	rate of occurence		A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time.
http://purl.obolibrary.org/obo/PATO_0000048	hardness	http://purl.obolibrary.org/obo/PATO_0001546	quality of a solid		A physical quality inhering in a bearer by virtue of the bearer's resistance to pressure, being broken, or pierced
http://purl.obolibrary.org/obo/PATO_0000049	intensity	http://purl.obolibrary.org/obo/PATO_0000068	qualitative		A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force.
http://purl.obolibrary.org/obo/PATO_0000050	life span	http://purl.obolibrary.org/obo/PATO_0000165	time		A time quality inhering in a bearer by virtue of the bearer's expected maximum age.
http://purl.obolibrary.org/obo/PATO_0000051	morphology	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.
http://purl.obolibrary.org/obo/PATO_0000052	shape	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).
http://purl.obolibrary.org/obo/PATO_0000057	occurrence	http://purl.obolibrary.org/obo/PATO_0002323	temporal distribution quality		A quality of a single process inhering in a bearer by virtue of the bearer's occurrence.
http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts.
http://purl.obolibrary.org/obo/PATO_0000068	qualitative	http://purl.obolibrary.org/obo/PATO_0000001	quality		A quality of an entity that is descriptive or observational, typically not represented numerically.
http://purl.obolibrary.org/obo/PATO_0000069	deviation (from_normal)	http://purl.obolibrary.org/obo/PATO_0000068	qualitative		A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.
http://purl.obolibrary.org/obo/PATO_0000070	amount	http://purl.obolibrary.org/obo/PATO_0103000	quantitative		The number of entities of this type that are part of the whole organism.
http://purl.obolibrary.org/obo/PATO_0000078	rhythm quality	http://purl.obolibrary.org/obo/PATO_0002323	temporal distribution quality		A quality of a single process inhering in a bearer by virtue of the bearer's movement or variation characterized by the regular recurrence or alternation of different quantities or conditions.
http://purl.obolibrary.org/obo/PATO_0000082	persistence	http://purl.obolibrary.org/obo/PATO_0000078	rhythm quality		A rhythm quality inhering in a bearer by virtue of the repetitiveness of bearer's rhythm.
http://purl.obolibrary.org/obo/PATO_0000085	sensitivity toward	http://purl.obolibrary.org/obo/PATO_0001995	organismal quality		A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation.
http://purl.obolibrary.org/obo/PATO_0000117	size	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude.
http://purl.obolibrary.org/obo/PATO_0000119	height	http://purl.obolibrary.org/obo/PATO_0001708	1-D extent		A 1-D extent quality inhering in a bearer by virtue of the bearer's vertical dimension of extension.
http://purl.obolibrary.org/obo/PATO_0000133	orientation	http://purl.obolibrary.org/obo/PATO_0000140	position		A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object.
http://purl.obolibrary.org/obo/PATO_0000136	closure	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent.
http://purl.obolibrary.org/obo/PATO_0000140	position	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.
http://purl.obolibrary.org/obo/PATO_0000141	structure	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.
http://purl.obolibrary.org/obo/PATO_0000150	texture	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics.
http://purl.obolibrary.org/obo/PATO_0000161	rate	http://purl.obolibrary.org/obo/PATO_0002062	physical quality of a process		A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.
http://purl.obolibrary.org/obo/PATO_0000165	time	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality in which events occur in sequence.
http://purl.obolibrary.org/obo/PATO_0000188	coordination	http://purl.obolibrary.org/obo/PATO_0000186	behavioral quality		A behavioral quality inhering in a bearer by virtue of the bearer's having or lacking skillful and effective interaction of movement.
http://purl.obolibrary.org/obo/PATO_0000261	maturity	http://purl.obolibrary.org/obo/PATO_0001995	organismal quality		A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development.
http://purl.obolibrary.org/obo/PATO_0000274	fertility	http://purl.obolibrary.org/obo/PATO_0001434	reproductive quality		A reproductive quality inhering in a bearer by virtue of the bearer's initiating, sustaining, or supporting reproduction.
http://purl.obolibrary.org/obo/PATO_0000297	arrested	http://purl.obolibrary.org/obo/PATO_0002324	offset quality		A quality of a process which ends earlier than the natural end time or reference process.
http://purl.obolibrary.org/obo/PATO_0000299	mobile	http://purl.obolibrary.org/obo/PATO_0000004	mobility		A mobility quality of inhering in a bearer by virtue of the bearer's disposition to move freely.
http://purl.obolibrary.org/obo/PATO_0000318	blue	http://purl.obolibrary.org/obo/PATO_0000014	color		A color hue with low wavelength of that portion of the visible spectrum lying between green and indigo, evoked in the human observer by radiant energy with wavelengths of approximately 420 to 490 nanometers.
http://purl.obolibrary.org/obo/PATO_0000319	cyan	http://purl.obolibrary.org/obo/PATO_0000014	color		A color consisting of green and blue hue.
http://purl.obolibrary.org/obo/PATO_0000320	green	http://purl.obolibrary.org/obo/PATO_0000014	color		A color hue with medium-low wavelength of that portion of the visible spectrum lying between yellow and blue, evoked in the human observer by radiant energy with wavelengths of approximately 490 to 570 nanometers.
http://purl.obolibrary.org/obo/PATO_0000322	red	http://purl.obolibrary.org/obo/PATO_0000014	color		A color hue with high wavelength of the long-wave end of the visible spectrum, evoked in the human observer by radiant energy with wavelengths of approximately 630 to 750 nanometers.
http://purl.obolibrary.org/obo/PATO_0000323	white	http://purl.obolibrary.org/obo/PATO_0000014	color		An achromatic color of maximum brightness; the color of objects that reflect nearly all light of all visible wavelengths.
http://purl.obolibrary.org/obo/PATO_0000328	low saturation	http://purl.obolibrary.org/obo/PATO_0000017	color saturation		A color saturation which is of low purity.
http://purl.obolibrary.org/obo/PATO_0000330	irregular spatial pattern	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency.
http://purl.obolibrary.org/obo/PATO_0000380	increased frequency	http://purl.obolibrary.org/obo/PATO_0055003	increased rate of occurrence		A frequency which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000381	decreased frequency	http://purl.obolibrary.org/obo/PATO_0055004	decreased rate of occurrence		A frequency which is relatively low.
http://purl.obolibrary.org/obo/PATO_0000386	hard	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A hardness quality of being rigid and resistant to pressure.
http://purl.obolibrary.org/obo/PATO_0000387	soft	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A hardness quality of giving little resistance to pressure.
http://purl.obolibrary.org/obo/PATO_0000389	acute	http://purl.obolibrary.org/obo/PATO_0001309	duration		A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course.
http://purl.obolibrary.org/obo/PATO_0000394	mild intensity	http://purl.obolibrary.org/obo/PATO_0000049	intensity		An intensity which is less than moderate in type or degree or effect or force.
http://purl.obolibrary.org/obo/PATO_0000395	moderate intensity	http://purl.obolibrary.org/obo/PATO_0000049	intensity		An intensity which is less than extreme in type or degree or effect or force.
http://purl.obolibrary.org/obo/PATO_0000396	severe intensity	http://purl.obolibrary.org/obo/PATO_0000049	intensity		An intensity which is extremely bad or unpleasant in type or degree or effect or force.
http://purl.obolibrary.org/obo/PATO_0000402	branched	http://purl.obolibrary.org/obo/PATO_0002009	branchiness		A branchiness quality inhering in a bearer by virtue of the bearer's having branches.
http://purl.obolibrary.org/obo/PATO_0000403	cleft	http://purl.obolibrary.org/obo/PATO_0001857	concave		A concave quality inhering in a bearer by virtue of the bearer's resembling a groove or fissure.
http://purl.obolibrary.org/obo/PATO_0000404	coiled	http://purl.obolibrary.org/obo/PATO_0001794	coiling		A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals).
http://purl.obolibrary.org/obo/PATO_0000405	curled	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's having parallel chains in undulate fashion on the border.
http://purl.obolibrary.org/obo/PATO_0000406	curved	http://purl.obolibrary.org/obo/PATO_0001591	curvature		A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend.
http://purl.obolibrary.org/obo/PATO_0000407	flat	http://purl.obolibrary.org/obo/PATO_0002254	flattened		A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature.
http://purl.obolibrary.org/obo/PATO_0000411	circular	http://purl.obolibrary.org/obo/PATO_0000947	elliptic		A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center.
http://purl.obolibrary.org/obo/PATO_0000413	square	http://purl.obolibrary.org/obo/PATO_0002317	parallelogram		A shape quality inhering in a bearer by virtue of the bearer's having an equal-sided rectangular form.
http://purl.obolibrary.org/obo/PATO_0000427	recurrent	http://purl.obolibrary.org/obo/PATO_0000057	occurrence		A quality of a single process inhering in a bearer by virtue of the bearer's occurring or appearing again or repeatedly.
http://purl.obolibrary.org/obo/PATO_0000440	regular spatial pattern	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement.
http://purl.obolibrary.org/obo/PATO_0000460	abnormal	http://purl.obolibrary.org/obo/PATO_0000069	deviation (from_normal)		A quality inhering in a bearer by virtue of the bearer's deviation from normal or average.
http://purl.obolibrary.org/obo/PATO_0000461	normal	http://purl.obolibrary.org/obo/PATO_0000068	qualitative		A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average.
http://purl.obolibrary.org/obo/PATO_0000462	absent	http://purl.obolibrary.org/obo/PATO_0000070	amount		A quality denoting the lack of an entity.
http://purl.obolibrary.org/obo/PATO_0000467	present	http://purl.obolibrary.org/obo/PATO_0000070	amount		A quality inhering in a bearer by virtue of the bearer's existence.
http://purl.obolibrary.org/obo/PATO_0000470	increased amount	http://purl.obolibrary.org/obo/PATO_0002300	increased quality		An amount which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000498	increased duration	http://purl.obolibrary.org/obo/PATO_0002304	increased process quality		A duration quality of a process which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000499	decreased duration	http://purl.obolibrary.org/obo/PATO_0002302	decreased process quality		A duration quality of a process which is relatively low.
http://purl.obolibrary.org/obo/PATO_0000502	delayed	http://purl.obolibrary.org/obo/PATO_0002325	onset quality		A quality of a process which starts later than the natural start time or the reference process.
http://purl.obolibrary.org/obo/PATO_0000516	sensitive toward	http://purl.obolibrary.org/obo/PATO_0000085	sensitivity toward		A quality inhering in a bearer by virtue of the bearer's having sensitivity toward an external stimulus.
http://purl.obolibrary.org/obo/PATO_0000547	photosensitive	http://purl.obolibrary.org/obo/PATO_0000927	photosensitivity		A photosensitivity quality inhering in a bearer by virtue of the bearer's exhibiting photosensitivity.
http://purl.obolibrary.org/obo/PATO_0000569	decreased height	http://purl.obolibrary.org/obo/PATO_0000587	decreased size		A height which is relatively low.
http://purl.obolibrary.org/obo/PATO_0000570	increased height	http://purl.obolibrary.org/obo/PATO_0000586	increased size		A height which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000573	increased length	http://purl.obolibrary.org/obo/PATO_0000122	length		A length quality which is relatively large.
http://purl.obolibrary.org/obo/PATO_0000574	decreased length	http://purl.obolibrary.org/obo/PATO_0000122	length		A length quality which is relatively small.
http://purl.obolibrary.org/obo/PATO_0000584	hypertrophic	http://purl.obolibrary.org/obo/PATO_0000595	increased volume		An increased size quality inhering in a bearer by virtue of the bearer's exhibiting enlargement of a cell or constituent group of cells (for example, organ).
http://purl.obolibrary.org/obo/PATO_0000585	hypotrophic	http://purl.obolibrary.org/obo/PATO_0000596	decreased volume		A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced size of a cell or constituent group of cells (for example, organ).
http://purl.obolibrary.org/obo/PATO_0000586	increased size	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A size quality which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000587	decreased size	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A size quality which is relatively low.
http://purl.obolibrary.org/obo/PATO_0000591	increased thickness	http://purl.obolibrary.org/obo/PATO_0000915	thickness		A thickness which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000592	decreased thickness	http://purl.obolibrary.org/obo/PATO_0000915	thickness		A thickness which is relatively low.
http://purl.obolibrary.org/obo/PATO_0000595	increased volume	http://purl.obolibrary.org/obo/PATO_0000918	volume		A volume which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000596	decreased volume	http://purl.obolibrary.org/obo/PATO_0000918	volume		A volume which is relatively low.
http://purl.obolibrary.org/obo/PATO_0000599	decreased width	http://purl.obolibrary.org/obo/PATO_0000921	width		A width which is relatively small.
http://purl.obolibrary.org/obo/PATO_0000600	increased width	http://purl.obolibrary.org/obo/PATO_0000921	width		A width which is relatively large.
http://purl.obolibrary.org/obo/PATO_0000608	closed	http://purl.obolibrary.org/obo/PATO_0000136	closure		A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view.
http://purl.obolibrary.org/obo/PATO_0000609	closure incomplete	http://purl.obolibrary.org/obo/PATO_0000610	open		A morphological quality inhering in a bearer by virtue of the bearer's affording not completed blocked passage or view.
http://purl.obolibrary.org/obo/PATO_0000610	open	http://purl.obolibrary.org/obo/PATO_0000136	closure		A morphological quality inhering in a bearer by virtue of the bearer's affording unobstructed passage or view.
http://purl.obolibrary.org/obo/PATO_0000614	oriented	http://purl.obolibrary.org/obo/PATO_0000440	regular spatial pattern		A pattern where all the repeated elements are oriented in the same direction.
http://purl.obolibrary.org/obo/PATO_0000616	asymmetrical	http://purl.obolibrary.org/obo/PATO_0000965	symmetry		A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry.
http://purl.obolibrary.org/obo/PATO_0000617	bent	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's having one or more angle(s) in its length.
http://purl.obolibrary.org/obo/PATO_0000618	bilateral	http://purl.obolibrary.org/obo/PATO_0000140	position		A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided.
http://purl.obolibrary.org/obo/PATO_0000619	crowded	http://purl.obolibrary.org/obo/PATO_0000140	position		A positional quality inhering in a bearer by virtue of the bearer's being overfilled.
http://purl.obolibrary.org/obo/PATO_0000623	exserted	http://purl.obolibrary.org/obo/PATO_0001598	protruding		A quality inhering in a bearer by virtue of the bearer's protruding or projecting from the body.
http://purl.obolibrary.org/obo/PATO_0000625	inverted	http://purl.obolibrary.org/obo/PATO_0000614	oriented		An oriented quality inhering in a bearer by virtue of the bearer's being reversed in position, order, or condition.
http://purl.obolibrary.org/obo/PATO_0000627	localized	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A spatial pattern quality inhering in a bearer by virtue of the bearer's being confined or restricted to a particular location.
http://purl.obolibrary.org/obo/PATO_0000628	mislocalised	http://purl.obolibrary.org/obo/PATO_0002181	displaced		A positional quality inhering in a bearer by virtue the bearer's being changed in abnormal position.
http://purl.obolibrary.org/obo/PATO_0000632	symmetrical	http://purl.obolibrary.org/obo/PATO_0000965	symmetry		A symmetry quality inhering in a bearer by virtue of the bearer's being capable of division by a longitudinal plane into similar halves.
http://purl.obolibrary.org/obo/PATO_0000634	unilateral	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A spatial pattern inhering in a bearer by virtue of the bearer's involvement of only one part or side.
http://purl.obolibrary.org/obo/PATO_0000635	unlocalised	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A spatial pattern inhering in a bearer by virtue of the bearer's not being confined or restricted to a particular location.
http://purl.obolibrary.org/obo/PATO_0000639	degenerate	http://purl.obolibrary.org/obo/PATO_0002037	degeneration		A structural quality inhering in a bearer whose structure deteriorates or is lost over time due to an active pathological process.
http://purl.obolibrary.org/obo/PATO_0000640	dysplastic	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's exhibiting an alteration in size, shape or organization of its constituent cells.
http://purl.obolibrary.org/obo/PATO_0000642	fused with	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's being merged with another entity.
http://purl.obolibrary.org/obo/PATO_0000643	herniated	http://purl.obolibrary.org/obo/PATO_0001598	protruding		A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it.
http://purl.obolibrary.org/obo/PATO_0000644	hyperplastic	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting an increased number of cells, typically associated with an increase in size.
http://purl.obolibrary.org/obo/PATO_0000645	hypoplastic	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A physical quality inhering in an organ or tissue by virtue of the bearer's exhibiting a decreased number of cells, typically associated with a decrease in size.
http://purl.obolibrary.org/obo/PATO_0000646	malformed	http://purl.obolibrary.org/obo/PATO_0001617	deformed		A morphological quality inhering in a bearer by virtue of the bearer's being distorted during formation.
http://purl.obolibrary.org/obo/PATO_0000647	necrotic	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's undergoing unprogrammed cell death.
http://purl.obolibrary.org/obo/PATO_0000648	obstructed	http://purl.obolibrary.org/obo/PATO_0000608	closed		A morphological quality inhering in a bearer by virtue of the bearer's being blocked or filled with obstacles or an obstacle.
http://purl.obolibrary.org/obo/PATO_0000651	unfused from	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's being no longer merged with another entity.
http://purl.obolibrary.org/obo/PATO_0000665	high brightness	http://purl.obolibrary.org/obo/PATO_0000016	color brightness		A color brightness which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000688	asynchronous	http://purl.obolibrary.org/obo/PATO_0000057	occurrence		A quality of a single process inhering in a bearer by virtue of the bearer's not occurring or existing at the same time or having the same period or phase.
http://purl.obolibrary.org/obo/PATO_0000689	continuous	http://purl.obolibrary.org/obo/PATO_0000057	occurrence		A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent.
http://purl.obolibrary.org/obo/PATO_0000692	heterochronic	http://purl.obolibrary.org/obo/PATO_0000057	occurrence		A quality of a single process inhering in a bearer by virtue of the bearer's origin or development at an unusual time or out of the regular sequence.
http://purl.obolibrary.org/obo/PATO_0000694	premature	http://purl.obolibrary.org/obo/PATO_0002325	onset quality		A quality of a process which starts earlier than the natural start time or the reference process.
http://purl.obolibrary.org/obo/PATO_0000700	rough	http://purl.obolibrary.org/obo/PATO_0000150	texture		A texture quality inhering in a bearer by virtue of the bearer's irregular surface.
http://purl.obolibrary.org/obo/PATO_0000701	smooth	http://purl.obolibrary.org/obo/PATO_0000150	texture		A texture quality inhering in a bearer by virtue of the bearer's processing a surface free of roughness or irregularities.
http://purl.obolibrary.org/obo/PATO_0000760	increased behavioural activity	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting increased activity.
http://purl.obolibrary.org/obo/PATO_0000761	decreased behavioural activity	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting reduced activity.
http://purl.obolibrary.org/obo/PATO_0000763	paralysed	http://purl.obolibrary.org/obo/PATO_0002076	movement behavioral quality		A behavioral quality inhering in a bearer by virtue of the bearer's being affected by loss of the ability to move a body part.
http://purl.obolibrary.org/obo/PATO_0000890	male sterile	http://purl.obolibrary.org/obo/PATO_0000956	sterile		A male fertility quality inhering in a male by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.
http://purl.obolibrary.org/obo/PATO_0000892	female sterile	http://purl.obolibrary.org/obo/PATO_0000956	sterile		A female fertility quality inhering in a female by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.
http://purl.obolibrary.org/obo/PATO_0000911	decreased rate	http://purl.obolibrary.org/obo/PATO_0002302	decreased process quality		A rate which is relatively low.
http://purl.obolibrary.org/obo/PATO_0000912	increased rate	http://purl.obolibrary.org/obo/PATO_0002304	increased process quality		A rate which is relatively high.
http://purl.obolibrary.org/obo/PATO_0000915	thickness	http://purl.obolibrary.org/obo/PATO_0001708	1-D extent		A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width.
http://purl.obolibrary.org/obo/PATO_0000921	width	http://purl.obolibrary.org/obo/PATO_0001708	1-D extent		A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite.
http://purl.obolibrary.org/obo/PATO_0000927	photosensitivity	http://purl.obolibrary.org/obo/PATO_0000085	sensitivity toward		A quality inhering in a bearer by virtue of the bearer's disposition to being sensitivity to the action of radiant energy.
http://purl.obolibrary.org/obo/PATO_0000941	vacuolated	http://purl.obolibrary.org/obo/PATO_0002014	structure, cavities		A structural quality inhering in a cytoplasm that contains fluid filled cavities.
http://purl.obolibrary.org/obo/PATO_0000944	sharpness	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point.
http://purl.obolibrary.org/obo/PATO_0000946	oblong	http://purl.obolibrary.org/obo/PATO_0002006	2-D shape		A shape quality inhering in a bearer by virtue of the bearer's having a somewhat elongated form with approximately parallel sides.
http://purl.obolibrary.org/obo/PATO_0000947	elliptic	http://purl.obolibrary.org/obo/PATO_0002318	superelliptic		A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section.
http://purl.obolibrary.org/obo/PATO_0000950	grey	http://purl.obolibrary.org/obo/PATO_0000014	color		A color between white and black colors.
http://purl.obolibrary.org/obo/PATO_0000956	sterile	http://purl.obolibrary.org/obo/PATO_0000274	fertility		A fertility quality inhering in a bearer by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.
http://purl.obolibrary.org/obo/PATO_0000957	opacity	http://purl.obolibrary.org/obo/PATO_0001300	optical quality		An optical quality which obtains by virtue of the ability of the bearer to absorb visible light.
http://purl.obolibrary.org/obo/PATO_0000963	opaque	http://purl.obolibrary.org/obo/PATO_0000957	opacity		A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy.
http://purl.obolibrary.org/obo/PATO_0000964	transparent	http://purl.obolibrary.org/obo/PATO_0000957	opacity		A optical quality inhering in a bearer by virtue of the bearer's lacking opacity.
http://purl.obolibrary.org/obo/PATO_0000965	symmetry	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis.
http://purl.obolibrary.org/obo/PATO_0000967	undulate	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's having a sinuate margin and rippled surface.
http://purl.obolibrary.org/obo/PATO_0000969	dwarf-like	http://purl.obolibrary.org/obo/PATO_0000587	decreased size		A size quality inhering in a bearer by virtue of the bearer's being abnormally small.
http://purl.obolibrary.org/obo/PATO_0000992	viscosity	http://purl.obolibrary.org/obo/PATO_0001548	quality of a liquid		A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow.
http://purl.obolibrary.org/obo/PATO_0000998	viscous	http://purl.obolibrary.org/obo/PATO_0000992	viscosity		A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity.
http://purl.obolibrary.org/obo/PATO_0001018	physical quality	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.
http://purl.obolibrary.org/obo/PATO_0001019	mass density	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A physical quality which inheres in a bearer by virtue of some influence is exerted by the bearer's mass per unit size.
http://purl.obolibrary.org/obo/PATO_0001020	damage	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of whether the bearer has been harmed or injured or spoiled.
http://purl.obolibrary.org/obo/PATO_0001031	elasticity	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way.
http://purl.obolibrary.org/obo/PATO_0001043	susceptibility toward	http://purl.obolibrary.org/obo/PATO_0000085	sensitivity toward		A quality inhering in an entity by virtue of the bearer's propensity to resist an external stimulus.
http://purl.obolibrary.org/obo/PATO_0001046	resistance to	http://purl.obolibrary.org/obo/PATO_0001995	organismal quality		A quality inhering in a bearer by virtue of the bearer's disposition to resist to a stimulus.
http://purl.obolibrary.org/obo/PATO_0001152	susceptible toward	http://purl.obolibrary.org/obo/PATO_0001043	susceptibility toward		A quality inhering in a bearer by virtue of the bearer's having susceptibilty toward an external stimulus.
http://purl.obolibrary.org/obo/PATO_0001154	elongated	http://purl.obolibrary.org/obo/PATO_0000052	shape		A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width.
http://purl.obolibrary.org/obo/PATO_0001159	concentrated	http://purl.obolibrary.org/obo/PATO_0000033	concentration of		A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration.
http://purl.obolibrary.org/obo/PATO_0001162	increased concentration	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A concentration which is higher relative to the normal or average.
http://purl.obolibrary.org/obo/PATO_0001163	decreased concentration	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A concentration which is lower relative to the normal or average.
http://purl.obolibrary.org/obo/PATO_0001164	dense	http://purl.obolibrary.org/obo/PATO_0001019	mass density		A physical quality which inheres in a bearer by virtue of the bearer's exhibiting density.
http://purl.obolibrary.org/obo/PATO_0001171	elastic	http://purl.obolibrary.org/obo/PATO_0001031	elasticity		An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way.
http://purl.obolibrary.org/obo/PATO_0001178	resistant to	http://purl.obolibrary.org/obo/PATO_0001046	resistance to		A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus.
http://purl.obolibrary.org/obo/PATO_0001190	juvenile	http://purl.obolibrary.org/obo/PATO_0000261	maturity		A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed.
http://purl.obolibrary.org/obo/PATO_0001195	proximal to	http://purl.obolibrary.org/obo/PATO_0000140	position		A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity.
http://purl.obolibrary.org/obo/PATO_0001201	Y-shaped	http://purl.obolibrary.org/obo/PATO_0001890	tripartite		A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter Y.
http://purl.obolibrary.org/obo/PATO_0001230	strength	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality inhering in a bearer by virtue of the bearer's power or force.
http://purl.obolibrary.org/obo/PATO_0001236	process quality	http://purl.obolibrary.org/obo/PATO_0000001	quality		A quality which inheres in an process.
http://purl.obolibrary.org/obo/PATO_0001241	physical object quality	http://purl.obolibrary.org/obo/PATO_0000001	quality		A quality which inheres in a continuant.
http://purl.obolibrary.org/obo/PATO_0001292	full-spectrum EM radiation quality	http://purl.obolibrary.org/obo/PATO_0070060	quality of interaction of a substance with electromagnetic radiation		An EM radiation quality that is independent of the EM wavelength range.
http://purl.obolibrary.org/obo/PATO_0001294	radiation reflective quality	http://purl.obolibrary.org/obo/PATO_0001292	full-spectrum EM radiation quality		A scalar EM radiation quality which obtains by the capacity of the bearer to scatter or reflect radiation.
http://purl.obolibrary.org/obo/PATO_0001297	reflectivity	http://purl.obolibrary.org/obo/PATO_0001294	radiation reflective quality		A radiation reflective quality inhering in a bearer by virtue of the ratio of the energy of a wave reflected from its surface to the energy possessed by the wave striking the bearer's surface.
http://purl.obolibrary.org/obo/PATO_0001300	optical quality	http://purl.obolibrary.org/obo/PATO_0070060	quality of interaction of a substance with electromagnetic radiation		An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.
http://purl.obolibrary.org/obo/PATO_0001301	chromatic property	http://purl.obolibrary.org/obo/PATO_0001300	optical quality		An optical quality that is the mixture, purity or pattern of wavelengths of light perceived by the observer.
http://purl.obolibrary.org/obo/PATO_0001303	variability	http://purl.obolibrary.org/obo/PATO_0000001	quality		A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing.
http://purl.obolibrary.org/obo/PATO_0001309	duration	http://purl.obolibrary.org/obo/PATO_0002062	physical quality of a process		A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.
http://purl.obolibrary.org/obo/PATO_0001334	diameter	http://purl.obolibrary.org/obo/PATO_0001708	1-D extent		A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary.
http://purl.obolibrary.org/obo/PATO_0001354	translucent	http://purl.obolibrary.org/obo/PATO_0000957	opacity		A optical quality inhering in a bearer by virtue of the bearer's exhibiting low opacity.
http://purl.obolibrary.org/obo/PATO_0001355	convex	http://purl.obolibrary.org/obo/PATO_0002005	concavity		A shape quality that obtains by virtue of the bearer having inward facing edges; having a surface or boundary that curves or bulges outward, as the exterior of a sphere.
http://purl.obolibrary.org/obo/PATO_0001362	fragile	http://purl.obolibrary.org/obo/PATO_0001662	fragility		A structural quality inhering in a bearer by virtue of the bearer's disposition to being easily damaged or destroyed.
http://purl.obolibrary.org/obo/PATO_0001365	spiny	http://purl.obolibrary.org/obo/PATO_0001925	surface feature shape		A surface feature shape quality inhering in a bearer by virtue of the bearer's having spines, thorns or similar thin projections on its surface.
http://purl.obolibrary.org/obo/PATO_0001393	euploid	http://purl.obolibrary.org/obo/PATO_0001374	ploidy		A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.
http://purl.obolibrary.org/obo/PATO_0001397	cellular potency	http://purl.obolibrary.org/obo/PATO_0001396	cellular quality		A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types.
http://purl.obolibrary.org/obo/PATO_0001400	unipotent	http://purl.obolibrary.org/obo/PATO_0001397	cellular potency		A cellular potency that is the capacity to produce only one differentiated cell type.
http://purl.obolibrary.org/obo/PATO_0001401	oligopotent	http://purl.obolibrary.org/obo/PATO_0001397	cellular potency		A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity.
http://purl.obolibrary.org/obo/PATO_0001402	multipotent	http://purl.obolibrary.org/obo/PATO_0001397	cellular potency		A cellular potency that is the capacity to form multiple differentiated cell types.
http://purl.obolibrary.org/obo/PATO_0001404	nucleate quality	http://purl.obolibrary.org/obo/PATO_0001396	cellular quality		A cellular quality inhering in a bearer by virtue of bearer's number of nuclei.
http://purl.obolibrary.org/obo/PATO_0001405	anucleate	http://purl.obolibrary.org/obo/PATO_0001404	nucleate quality		A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus.
http://purl.obolibrary.org/obo/PATO_0001407	mononucleate	http://purl.obolibrary.org/obo/PATO_0002505	nucleated		A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus.
http://purl.obolibrary.org/obo/PATO_0001408	ciliated	http://purl.obolibrary.org/obo/PATO_0001396	cellular quality		A cellular quality inhering in a bearer by virtue of the bearer's having one or more cilia as a part.
http://purl.obolibrary.org/obo/PATO_0001409	spindle-shaped	http://purl.obolibrary.org/obo/PATO_0002007	convex 3-D shape		A shape quality inhering in a bearer by virtue of the bearer's resembling a long tapered rod.
http://purl.obolibrary.org/obo/PATO_0001410	striated	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel.
http://purl.obolibrary.org/obo/PATO_0001419	sharp	http://purl.obolibrary.org/obo/PATO_0000944	sharpness		A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge.
http://purl.obolibrary.org/obo/PATO_0001434	reproductive quality	http://purl.obolibrary.org/obo/PATO_0001995	organismal quality		An organismal quality inhering in a bearer by virtue of the bearer's ability to produce new life or offspring.
http://purl.obolibrary.org/obo/PATO_0001435	attachment quality	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's having connection or association with another entity.
http://purl.obolibrary.org/obo/PATO_0001439	tonicity	http://purl.obolibrary.org/obo/PATO_0001579	contractility		A contractile quality inhering in a bearer by virtue of the bearer's elastic tension that facilitate response to stimuli.
http://purl.obolibrary.org/obo/PATO_0001442	wholeness	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of whether the bearer includes all its components.
http://purl.obolibrary.org/obo/PATO_0001444	broken	http://purl.obolibrary.org/obo/PATO_0001442	wholeness		A structural quality inhering in a bearer by virtue of the bearer's components no longer being in a single contiguous unit.
http://purl.obolibrary.org/obo/PATO_0001447	calcified	http://purl.obolibrary.org/obo/PATO_0000025	composition		A composition quality inhering in an bearer by virtue of the bearer's being encrusted or impregnated with calcium carbonate (CHEBI:3311).
http://purl.obolibrary.org/obo/PATO_0001449	cartilaginous	http://purl.obolibrary.org/obo/PATO_0000025	composition		A composition quality inhering in an bearer by virtue of the bearer's cartilage quantities.
http://purl.obolibrary.org/obo/PATO_0001450	edematous	http://purl.obolibrary.org/obo/PATO_0000025	composition		A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of extracellular fluid.
http://purl.obolibrary.org/obo/PATO_0001453	detached from	http://purl.obolibrary.org/obo/PATO_0001435	attachment quality		An attachment quality inhering in a bearer by virtue of the bearer's lacking connection or association with another entity.
http://purl.obolibrary.org/obo/PATO_0001457	sensitivity of a process	http://purl.obolibrary.org/obo/PATO_0002062	physical quality of a process		A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation.
http://purl.obolibrary.org/obo/PATO_0001468	curved dorsal	http://purl.obolibrary.org/obo/PATO_0000406	curved		A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the back or upper surface of an organism.
http://purl.obolibrary.org/obo/PATO_0001469	curved ventral	http://purl.obolibrary.org/obo/PATO_0000406	curved		A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the abdomen of an organism.
http://purl.obolibrary.org/obo/PATO_0001470	ratio	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality inhering in a bearer by virtue of the bearer's magnitude in proportion to the magnitude of another entity.
http://purl.obolibrary.org/obo/PATO_0001472	decreased depth	http://purl.obolibrary.org/obo/PATO_0001595	depth		A depth which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001473	duplicated	http://purl.obolibrary.org/obo/PATO_0000470	increased amount		A quality inhering in a bearer by virtue of the bearer's being present in two copies.
http://purl.obolibrary.org/obo/PATO_0001474	anteverted	http://purl.obolibrary.org/obo/PATO_0000614	oriented		An oriented quality inhering in a bearer by virtue of the bearer's axis being positioned forward.
http://purl.obolibrary.org/obo/PATO_0001475	increased position	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A position which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001476	decreased position	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A positional which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001477	retracted	http://purl.obolibrary.org/obo/PATO_0000140	position		A positional quality inhering in a bearer by virtue of the bearer's being drawn in or pulled back from any given point.
http://purl.obolibrary.org/obo/PATO_0001481	sloped	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's having an oblique or slanted direction.
http://purl.obolibrary.org/obo/PATO_0001482	prominent	http://purl.obolibrary.org/obo/PATO_0015007	prominence		A quality inhering in a bearer by virtue of the bearer's standing out or projecting beyond a surface or line.
http://purl.obolibrary.org/obo/PATO_0001483	aplastic	http://purl.obolibrary.org/obo/PATO_0002291	agenesis		Absence of an organ, tissue or cell due to failure to develop from a primordium or precursor cell.
http://purl.obolibrary.org/obo/PATO_0001488	cellular motility	http://purl.obolibrary.org/obo/PATO_0001396	cellular quality		A cellular quality inhering in a cell by virtue of whether the bearer exhibits the ability to move spontaneously.
http://purl.obolibrary.org/obo/PATO_0001495	notched	http://purl.obolibrary.org/obo/PATO_0001857	concave		A concave quality inhering in a bearer by virtue of the bearer's shape being a V-shaped cut.
http://purl.obolibrary.org/obo/PATO_0001499	spherical	http://purl.obolibrary.org/obo/PATO_0001865	spheroid		A spheroid quality inhering in a bearer by virtue of the bearer's resembling a ball (a sphere whose equatorial diameter is equal to the polar diameter).
http://purl.obolibrary.org/obo/PATO_0001500	tapered	http://purl.obolibrary.org/obo/PATO_0001419	sharp		A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end.
http://purl.obolibrary.org/obo/PATO_0001501	immature	http://purl.obolibrary.org/obo/PATO_0000261	maturity		A quality inhering in a bearer by virtue of the bearer's lacking complete growth, differentiation, or development.
http://purl.obolibrary.org/obo/PATO_0001505	separated from	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's not being in contact with another entity, or of no longer being connected or joined with another entity.
http://purl.obolibrary.org/obo/PATO_0001507	disrupted	http://purl.obolibrary.org/obo/PATO_0000057	occurrence		A quality of a single process inhering in a bearer by virtue of the bearer's being interrupted of its normal course.
http://purl.obolibrary.org/obo/PATO_0001509	functionality	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s).
http://purl.obolibrary.org/obo/PATO_0001510	functional	http://purl.obolibrary.org/obo/PATO_0001509	functionality		A functionality quality held by the bearer when the latter is able to perform a regular function(s).
http://purl.obolibrary.org/obo/PATO_0001511	non-functional	http://purl.obolibrary.org/obo/PATO_0001509	functionality		A disfunctional quality held by the bearer when the latter is unable to perform a regular function(s).
http://purl.obolibrary.org/obo/PATO_0001512	punctate	http://purl.obolibrary.org/obo/PATO_0000330	irregular spatial pattern		A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits.
http://purl.obolibrary.org/obo/PATO_0001543	flexibility	http://purl.obolibrary.org/obo/PATO_0001546	quality of a solid		A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking.
http://purl.obolibrary.org/obo/PATO_0001544	flexible	http://purl.obolibrary.org/obo/PATO_0001543	flexibility		A physical quality inhering in a bearer by virtue of the bearer's ability of being turned, bowed, or twisted without breaking.
http://purl.obolibrary.org/obo/PATO_0001545	inflexible	http://purl.obolibrary.org/obo/PATO_0001543	flexibility		A physical quality inhering in a bearer by virtue of the bearer's inability of being turned, bowed, or twisted without breaking.
http://purl.obolibrary.org/obo/PATO_0001549	increased sensitivity toward	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A sensitivity toward an external stimulus which is higher than normal/average.
http://purl.obolibrary.org/obo/PATO_0001550	decreased sensitivity toward	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A sensitivity toward an external stimulus which is lower than normal/average.
http://purl.obolibrary.org/obo/PATO_0001551	increased sensitivity of a process	http://purl.obolibrary.org/obo/PATO_0002304	increased process quality		A sensitivity of a process which is higher than normal or average.
http://purl.obolibrary.org/obo/PATO_0001552	decreased sensitivity of a process	http://purl.obolibrary.org/obo/PATO_0002302	decreased process quality		A sensitivity of a process which is lower than normal or average.
http://purl.obolibrary.org/obo/PATO_0001555	has number of	http://purl.obolibrary.org/obo/PATO_0000070	amount		The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.
http://purl.obolibrary.org/obo/PATO_0001558	lacking processual parts	http://purl.obolibrary.org/obo/PATO_0001564	extra or missing processual parts		A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity.
http://purl.obolibrary.org/obo/PATO_0001559	having extra function	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A functionality quality which is held by the bearer when the latter is able to perform additional or different function(s).
http://purl.obolibrary.org/obo/PATO_0001561	having extra processual parts	http://purl.obolibrary.org/obo/PATO_0001564	extra or missing processual parts		A quality of a process inhering in a bearer by virtue of the bearer's having additional processual parts.
http://purl.obolibrary.org/obo/PATO_0001562	decreased mass	http://purl.obolibrary.org/obo/PATO_0000125	mass		A mass which is lower than normal or average.
http://purl.obolibrary.org/obo/PATO_0001563	increased mass	http://purl.obolibrary.org/obo/PATO_0000125	mass		A mass which is higher than normal or average.
http://purl.obolibrary.org/obo/PATO_0001564	extra or missing processual parts	http://purl.obolibrary.org/obo/PATO_0001236	process quality		A quality of a process inhering in a bearer by virtue of the bearer's processual parts.
http://purl.obolibrary.org/obo/PATO_0001571	dilated	http://purl.obolibrary.org/obo/PATO_0000586	increased size		A size quality inhering in a bearer by virtue of the bearer's being made wider or larger in all dimensions.
http://purl.obolibrary.org/obo/PATO_0001575	decreased pressure	http://purl.obolibrary.org/obo/PATO_0001025	pressure		A pressure which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001576	increased pressure	http://purl.obolibrary.org/obo/PATO_0001025	pressure		A pressure which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001579	contractility	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A physical quality that is the ability to contract or shrink.
http://purl.obolibrary.org/obo/PATO_0001580	increased contractility	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A contractility which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001581	decreased contractility	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A contractility which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001590	overlap with	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's coinciding spatially, partially or wholly with another entity.
http://purl.obolibrary.org/obo/PATO_0001591	curvature	http://purl.obolibrary.org/obo/PATO_0000052	shape		A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending.
http://purl.obolibrary.org/obo/PATO_0001592	increased curvature	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A curvature which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001593	decreased curvature	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A curvature which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001594	arched	http://purl.obolibrary.org/obo/PATO_0001857	concave		A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch.
http://purl.obolibrary.org/obo/PATO_0001595	depth	http://purl.obolibrary.org/obo/PATO_0001708	1-D extent		A 1-D extent quality inhering in a bearer by virtue of the bearer's downward or backward or inward dimension.
http://purl.obolibrary.org/obo/PATO_0001596	increased depth	http://purl.obolibrary.org/obo/PATO_0001595	depth		A depth quality which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001597	everted	http://purl.obolibrary.org/obo/PATO_0000614	oriented		An oriented quality inhering in a bearer by virtue of the bearer's being turned outward in placement.
http://purl.obolibrary.org/obo/PATO_0001598	protruding	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality inhering in a bearer by virtue of the bearer's extending out above or beyond a surface or boundary.
http://purl.obolibrary.org/obo/PATO_0001599	rotated	http://purl.obolibrary.org/obo/PATO_0000614	oriented		An oriented quality inhering in a bearer by virtue of the bearer's being relocated around an axis.
http://purl.obolibrary.org/obo/PATO_0001600	posteriorly rotated	http://purl.obolibrary.org/obo/PATO_0001599	rotated		A rotation quality inhering in a bearer by virtue of being rotated towards the rear of organism.
http://purl.obolibrary.org/obo/PATO_0001602	distended	http://purl.obolibrary.org/obo/PATO_0000586	increased size		A size quality inhering in a bearer by virtue of the bearer's being abnormally expanded or increased in size.
http://purl.obolibrary.org/obo/PATO_0001603	increased life span	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A life span which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001604	decreased life span	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A life span which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001608	patchy	http://purl.obolibrary.org/obo/PATO_0000330	irregular spatial pattern		A spatial pattern inhering in a bearer by virtue of the bearer's being marked by, consisting of, or diversified with patches.
http://purl.obolibrary.org/obo/PATO_0001609	sparse	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A spatial pattern inhering in a bearer by virtue of the bearer's being scattered; spread irregularly, and at a distance from each other.
http://purl.obolibrary.org/obo/PATO_0001617	deformed	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.
http://purl.obolibrary.org/obo/PATO_0001618	increased tonicity	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A tonicity which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001619	decreased tonicity	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A tonicity which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001623	atrophied	http://purl.obolibrary.org/obo/PATO_0000587	decreased size		A size quality inhering in a bearer by virtue of a part or parts of the bearer's being decreased in size due to reduction in tissue mass through wasting.
http://purl.obolibrary.org/obo/PATO_0001624	decreased functionality	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A functionality quality held by the bearer when the latter exhibits decreased ability to perform a regular function(s).
http://purl.obolibrary.org/obo/PATO_0001625	increased functionality	http://purl.obolibrary.org/obo/PATO_0001559	having extra function		A functional quality held by the bearer when the latter exhibits increased ability to perform a regular function(s).
http://purl.obolibrary.org/obo/PATO_0001626	sufficiency	http://purl.obolibrary.org/obo/PATO_0001509	functionality		A structural quality inhering in a bearer by virtue of whether the bearer has enough functionality.
http://purl.obolibrary.org/obo/PATO_0001628	insufficient	http://purl.obolibrary.org/obo/PATO_0001626	sufficiency		A wholeness quality inhering in a bearer by virtue of the bearer's lacks enough functionality.
http://purl.obolibrary.org/obo/PATO_0001645	protruding into	http://purl.obolibrary.org/obo/PATO_0001598	protruding		A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary into the surface or boundary of another entity.
http://purl.obolibrary.org/obo/PATO_0001646	protruding out of	http://purl.obolibrary.org/obo/PATO_0001598	protruding		A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary and outwards in relation to the physical space occupied by another entity.
http://purl.obolibrary.org/obo/PATO_0001648	circumference	http://purl.obolibrary.org/obo/PATO_0001711	perimeter		An 1-D extent quality which is equal to the length of the closed curve of a circle.
http://purl.obolibrary.org/obo/PATO_0001649	curved lateral	http://purl.obolibrary.org/obo/PATO_0000406	curved		A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the side.
http://purl.obolibrary.org/obo/PATO_0001650	increased resistance to	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A resistance to a stimulus which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001651	decreased resistance to	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A resistance to a stimulus which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001652	alignment	http://purl.obolibrary.org/obo/PATO_0000140	position		A spatial quality inhering in a bearer by virtue of the bearer's spatial positioning with respect to an additional entity.
http://purl.obolibrary.org/obo/PATO_0001654	misaligned with	http://purl.obolibrary.org/obo/PATO_0001652	alignment		An alignment quality inhering in a bearer by virtue of the bearer's being in a improper spatial positioning with respect to an additional entity.
http://purl.obolibrary.org/obo/PATO_0001662	fragility	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's disposition to being damaged or destroyed.
http://purl.obolibrary.org/obo/PATO_0001669	increased susceptibility toward	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A susceptibility toward an external stimulus which is higher than normal/average.
http://purl.obolibrary.org/obo/PATO_0001670	decreased susceptibility toward	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A susceptibility toward an external stimulus which is lower than normal/average.
http://purl.obolibrary.org/obo/PATO_0001673	cystic	http://purl.obolibrary.org/obo/PATO_0002014	structure, cavities		Structure quality that is the presence of at least one sac-like closed membranous structure containing one or more liquid or solid organism substances.
http://purl.obolibrary.org/obo/PATO_0001690	contractile	http://purl.obolibrary.org/obo/PATO_0001579	contractility		A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted.
http://purl.obolibrary.org/obo/PATO_0001693	increased viscosity	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A viscosity which relatively high.
http://purl.obolibrary.org/obo/PATO_0001694	decreased viscosity	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A viscosity which relatively low.
http://purl.obolibrary.org/obo/PATO_0001697	decreased photosensitivity	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A photosensitivity which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001698	increased photosensitivity	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A photosensitivity which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001701	mature	http://purl.obolibrary.org/obo/PATO_0000261	maturity		A quality inhering in a bearer by virtue of the bearer's exhibiting complete growth, differentiation, or development.
http://purl.obolibrary.org/obo/PATO_0001707	behavioural active	http://purl.obolibrary.org/obo/PATO_0002265	behavioural activity		A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting marked activity.
http://purl.obolibrary.org/obo/PATO_0001708	1-D extent	http://purl.obolibrary.org/obo/PATO_0000117	size		A size quality inhering in an bearer by virtue of the bearer's extension in one dimension.
http://purl.obolibrary.org/obo/PATO_0001710	3-D extent	http://purl.obolibrary.org/obo/PATO_0000117	size		A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions.
http://purl.obolibrary.org/obo/PATO_0001711	perimeter	http://purl.obolibrary.org/obo/PATO_0001708	1-D extent		An 1-D extent quality inhering in two-dimensional bearer by virtue of being equal to the distance around it.
http://purl.obolibrary.org/obo/PATO_0001712	increased perimeter	http://purl.obolibrary.org/obo/PATO_0001711	perimeter		A perimeter which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001713	decreased perimeter	http://purl.obolibrary.org/obo/PATO_0001711	perimeter		A perimeter which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001714	increased diameter	http://purl.obolibrary.org/obo/PATO_0001334	diameter		A diameter which is relatively large.
http://purl.obolibrary.org/obo/PATO_0001715	decreased diameter	http://purl.obolibrary.org/obo/PATO_0001334	diameter		A diameter which is relatively small.
http://purl.obolibrary.org/obo/PATO_0001735	liquid configuration	http://purl.obolibrary.org/obo/PATO_0001548	quality of a liquid		A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids.
http://purl.obolibrary.org/obo/PATO_0001748	invaginated	http://purl.obolibrary.org/obo/PATO_0001857	concave		A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave.
http://purl.obolibrary.org/obo/PATO_0001776	increased flexibility	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A flexibility which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001777	decreased flexibility	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A flexibility which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001778	increased strength	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A strength which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001779	decreased strength	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A strength which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001780	dystrophic	http://purl.obolibrary.org/obo/PATO_0000587	decreased size		A size quality inhering in a bearer by virtue of the bearer's being abnormally developed, usually due to malnutrition.
http://purl.obolibrary.org/obo/PATO_0001782	increased intensity	http://purl.obolibrary.org/obo/PATO_0002300	increased quality		An intensity which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001783	decreased intensity	http://purl.obolibrary.org/obo/PATO_0002301	decreased quality		An intensity which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001784	bifurcated	http://purl.obolibrary.org/obo/PATO_0001786	split		A branched quality inhering in a bearer by virtue of the bearer's being divided into two branches.
http://purl.obolibrary.org/obo/PATO_0001785	splayed	http://purl.obolibrary.org/obo/PATO_0000406	curved		A curvature quality inhering in a bearer by virtue of the bearer's being curved outward.
http://purl.obolibrary.org/obo/PATO_0001786	split	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's being divided or broken up into parts or divisions.
http://purl.obolibrary.org/obo/PATO_0001787	rotational curvature	http://purl.obolibrary.org/obo/PATO_0001591	curvature		A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis.
http://purl.obolibrary.org/obo/PATO_0001788	increased mass density	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A density which is higher relative to the normal or average.
http://purl.obolibrary.org/obo/PATO_0001790	decreased mass density	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A density which is lower relative to the normal or average.
http://purl.obolibrary.org/obo/PATO_0001794	coiling	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's being wound in a continuous series of loops.
http://purl.obolibrary.org/obo/PATO_0001795	increased coiling	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A coiling which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001796	decreased coiling	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A coiling which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001800	water composition	http://purl.obolibrary.org/obo/PATO_0000025	composition		A composition quality inhering in an bearer by virtue of the quantities or relative ratios of water of the inhering entity.
http://purl.obolibrary.org/obo/PATO_0001801	decreased water composition	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A composition quality inhering in an bearer by virtue of the reduction in amount of water the bearer contains.
http://purl.obolibrary.org/obo/PATO_0001802	loose	http://purl.obolibrary.org/obo/PATO_0000330	irregular spatial pattern		A pattern quality inhering in a bearer by virtue of the bearer's not being compact or dense in arrangement.
http://purl.obolibrary.org/obo/PATO_0001810	wrinkled	http://purl.obolibrary.org/obo/PATO_0002255	grooved		A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by one or more creases in a normally smooth surface.
http://purl.obolibrary.org/obo/PATO_0001815	fatigability	http://purl.obolibrary.org/obo/PATO_0001230	strength		A strength quality inhering in a bearer by virtue of the bearer's disposition to lose strength.
http://purl.obolibrary.org/obo/PATO_0001816	increased fatigability	http://purl.obolibrary.org/obo/PATO_0001815	fatigability		A fatigability which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001818	progressive	http://purl.obolibrary.org/obo/PATO_0000057	occurrence		A quality of a single process inhering in a bearer by virtue of the bearer's increasing over time.
http://purl.obolibrary.org/obo/PATO_0001819	atretic	http://purl.obolibrary.org/obo/PATO_0000608	closed		A morphological quality inhering in a bearer by virtue of the bearer's absence or closure of a normal body orifice or tubular passage.
http://purl.obolibrary.org/obo/PATO_0001821	imperforate	http://purl.obolibrary.org/obo/PATO_0002014	structure, cavities		A structural quality inhering in a bearer by virtue of the bearer's having no opening.
http://purl.obolibrary.org/obo/PATO_0001822	wetness	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality inhering in a bearer by virtue of whether the bearer's being covered by a liquid.
http://purl.obolibrary.org/obo/PATO_0001824	dry	http://purl.obolibrary.org/obo/PATO_0001822	wetness		A wetness quality inhering in a bearer by virtue of the bearer's not being covered by a liquid.
http://purl.obolibrary.org/obo/PATO_0001827	pseudohermaphrodite	http://purl.obolibrary.org/obo/PATO_0001894	phenotypic sex		A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of one sex and external sexual characteristics of the other sex.
http://purl.obolibrary.org/obo/PATO_0001828	male pseudohermaphrodite	http://purl.obolibrary.org/obo/PATO_0001827	pseudohermaphrodite		A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of male and external sexual characteristics of female.
http://purl.obolibrary.org/obo/PATO_0001829	female pseudohermaphrodite	http://purl.obolibrary.org/obo/PATO_0001827	pseudohermaphrodite		A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of female and external sexual characteristics of male.
http://purl.obolibrary.org/obo/PATO_0001842	acidity	http://purl.obolibrary.org/obo/PATO_0000033	concentration of		A concentration quality inhering in a bearer by virtue of the bearer's containing acid (hydrogen ions).
http://purl.obolibrary.org/obo/PATO_0001843	decreased acidity	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		An acidity which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001844	increased acidity	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		An acidity which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001845	irregular rhythm	http://purl.obolibrary.org/obo/PATO_0000078	rhythm quality		A rhythm quality inhering in a bearer by virtue of the bearer's lacking rhythm lacking pattern.
http://purl.obolibrary.org/obo/PATO_0001847	constricted	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically.
http://purl.obolibrary.org/obo/PATO_0001850	scarred	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's being fibrous tissue that replaces normal tissue destroyed by injury or disease.
http://purl.obolibrary.org/obo/PATO_0001851	swollen	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structure quality inhering in a bearer by virtue of the bearer's exhibiting transient abnormal enlargement, not due to cell proliferation.
http://purl.obolibrary.org/obo/PATO_0001852	dislocated	http://purl.obolibrary.org/obo/PATO_0002181	displaced		A positional quality inhering in a bearer by virtue of the bearer's being out of its usual or proper place, or position due to it being physically moved from the normal location.
http://purl.obolibrary.org/obo/PATO_0001854	vertical	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A spatial pattern inhering in a bearer by virtue of the bearer's being situated at right angles to the horizon.
http://purl.obolibrary.org/obo/PATO_0001855	horizontal	http://purl.obolibrary.org/obo/PATO_0000140	position		A positional quality inhering in a bearer by virtue of the bearer's being in the plane of the horizon.
http://purl.obolibrary.org/obo/PATO_0001857	concave	http://purl.obolibrary.org/obo/PATO_0002005	concavity		A shape quality in a bearer by virtue of the bearer's curving inward.
http://purl.obolibrary.org/obo/PATO_0001863	chronic	http://purl.obolibrary.org/obo/PATO_0001309	duration		A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration.
http://purl.obolibrary.org/obo/PATO_0001865	spheroid	http://purl.obolibrary.org/obo/PATO_0002007	convex 3-D shape		A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating an ellipse about one of its principal axes. Includes spheres and oblate/prolate spheroids.
http://purl.obolibrary.org/obo/PATO_0001869	pathological	http://purl.obolibrary.org/obo/PATO_0000460	abnormal		A quality inhering in a bearer by virtue of the bearer's being abnormal and having a destructive effect on living tissue.
http://purl.obolibrary.org/obo/PATO_0001872	cuboid	http://purl.obolibrary.org/obo/PATO_0002007	convex 3-D shape		A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resemblance to a cube (a 3-D shape with a square cross section).
http://purl.obolibrary.org/obo/PATO_0001873	cylindrical	http://purl.obolibrary.org/obo/PATO_0002007	convex 3-D shape		A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section.
http://purl.obolibrary.org/obo/PATO_0001874	discoid	http://purl.obolibrary.org/obo/PATO_0001873	cylindrical		A shape quality inhering in a bearer by virtue of the bearer's being cylindrical, in which the height is less than the diameter.
http://purl.obolibrary.org/obo/PATO_0001875	triangular	http://purl.obolibrary.org/obo/PATO_0002006	2-D shape		A shape quality inhering in a bearer by virtue of the bearer's having three angles.
http://purl.obolibrary.org/obo/PATO_0001876	dumbbell-shaped	http://purl.obolibrary.org/obo/PATO_0002008	concave 3-D shape		A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having two parts, roughly spherical and of equal size, connected by a bar.
http://purl.obolibrary.org/obo/PATO_0001878	sigmoid	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped.
http://purl.obolibrary.org/obo/PATO_0001879	U-shaped	http://purl.obolibrary.org/obo/PATO_0002008	concave 3-D shape		A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter U.
http://purl.obolibrary.org/obo/PATO_0001883	clavate	http://purl.obolibrary.org/obo/PATO_0002008	concave 3-D shape		A concave 3-D shape quality inhering in a bearer by virtue of the bearer's gradually becoming thicker towards the end.
http://purl.obolibrary.org/obo/PATO_0001890	tripartite	http://purl.obolibrary.org/obo/PATO_0002008	concave 3-D shape		A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being divided into three branches.
http://purl.obolibrary.org/obo/PATO_0001891	ovate	http://purl.obolibrary.org/obo/PATO_0001865	spheroid		A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a continuous convex surface with an axis of symmetry and one axis longer than the other; egg-shaped.
http://purl.obolibrary.org/obo/PATO_0001894	phenotypic sex	http://purl.obolibrary.org/obo/PATO_0000047	biological sex		An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics.
http://purl.obolibrary.org/obo/PATO_0001898	increased circumference	http://purl.obolibrary.org/obo/PATO_0001712	increased perimeter		A circumference which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001899	decreased circumference	http://purl.obolibrary.org/obo/PATO_0001713	decreased perimeter		A circumference which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001908	multinucleate	http://purl.obolibrary.org/obo/PATO_0002505	nucleated		A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus.
http://purl.obolibrary.org/obo/PATO_0001910	folded	http://purl.obolibrary.org/obo/PATO_0001925	surface feature shape		A surface feature shape quality inhering in a bearer by virtue of the bearer's one part being layered over another connected part.
http://purl.obolibrary.org/obo/PATO_0001919	mislocalised dorsally	http://purl.obolibrary.org/obo/PATO_0000628	mislocalised		A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the back or upper surface of an organism.
http://purl.obolibrary.org/obo/PATO_0001921	mislocalised anteriorly	http://purl.obolibrary.org/obo/PATO_0000628	mislocalised		A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the front of an organism.
http://purl.obolibrary.org/obo/PATO_0001922	mislocalised posteriorly	http://purl.obolibrary.org/obo/PATO_0000628	mislocalised		A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the rear of an organism.
http://purl.obolibrary.org/obo/PATO_0001923	mislocalised laterally	http://purl.obolibrary.org/obo/PATO_0000628	mislocalised		A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the side of an organism.
http://purl.obolibrary.org/obo/PATO_0001925	surface feature shape	http://purl.obolibrary.org/obo/PATO_0000052	shape		A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell.
http://purl.obolibrary.org/obo/PATO_0001928	blistered	http://purl.obolibrary.org/obo/PATO_0000150	texture		A texture quality inhering in a bearer by virtue of a local accumulation of fluid underneath the surface of the bearer.
http://purl.obolibrary.org/obo/PATO_0001937	spatulate	http://purl.obolibrary.org/obo/PATO_0000946	oblong		A shape quality inhering in a bearer by virtue of the bearer's being oblong, with the lower end very much attenuated.
http://purl.obolibrary.org/obo/PATO_0001938	rhomboid	http://purl.obolibrary.org/obo/PATO_0002317	parallelogram		A spheroid quality inhering in a bearer by virtue of the bearer's being oval and a little angular in the middle.
http://purl.obolibrary.org/obo/PATO_0001940	gigantic	http://purl.obolibrary.org/obo/PATO_0000586	increased size		A size quality inhering in a bearer by virtue of the bearer's being many folds greater relative to the normal average.
http://purl.obolibrary.org/obo/PATO_0001948	furrowed	http://purl.obolibrary.org/obo/PATO_0002255	grooved		A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by two or more parallel channels.
http://purl.obolibrary.org/obo/PATO_0001955	cuneate	http://purl.obolibrary.org/obo/PATO_0001875	triangular		A shape quality inhering in a bearer by virtue of the bearer's being narrowly triangular, wider at the apex and tapering toward the base.
http://purl.obolibrary.org/obo/PATO_0001956	variability of size	http://purl.obolibrary.org/obo/PATO_0001303	variability		A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change.
http://purl.obolibrary.org/obo/PATO_0001957	decreased variability of size	http://purl.obolibrary.org/obo/PATO_0002301	decreased quality		A variability of size which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001958	increased variability of size	http://purl.obolibrary.org/obo/PATO_0002300	increased quality		A variability of size which is relatively high.
http://purl.obolibrary.org/obo/PATO_0001973	cuspidate	http://purl.obolibrary.org/obo/PATO_0001500	tapered		A shape quality inhering in a bearer by virtue of the bearer's being tapering gradually into a rigid point.
http://purl.obolibrary.org/obo/PATO_0001977	angular	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's having at least one salient angle on the margin.
http://purl.obolibrary.org/obo/PATO_0001987	saccular	http://purl.obolibrary.org/obo/PATO_0002014	structure, cavities		A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance.
http://purl.obolibrary.org/obo/PATO_0001988	quadrangular	http://purl.obolibrary.org/obo/PATO_0002006	2-D shape		A shape quality inhering in a bearer by virtue of the bearer's having four angles and four sides.
http://purl.obolibrary.org/obo/PATO_0001992	cellularity	http://purl.obolibrary.org/obo/PATO_0001995	organismal quality		An organismal quality inhering in a bearer by virtue of the bearer's consisting cells.
http://purl.obolibrary.org/obo/PATO_0001993	multicellular	http://purl.obolibrary.org/obo/PATO_0001992	cellularity		A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell.
http://purl.obolibrary.org/obo/PATO_0001997	decreased amount	http://purl.obolibrary.org/obo/PATO_0002301	decreased quality		An amount which is relatively low.
http://purl.obolibrary.org/obo/PATO_0001999	lacks parts or has fewer parts of type	http://purl.obolibrary.org/obo/PATO_0002083	altered number of		The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.
http://purl.obolibrary.org/obo/PATO_0002000	lacks all parts of type	http://purl.obolibrary.org/obo/PATO_0001999	lacks parts or has fewer parts of type		A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.
http://purl.obolibrary.org/obo/PATO_0002001	has fewer parts of type	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.
http://purl.obolibrary.org/obo/PATO_0002002	has extra parts of type	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.
http://purl.obolibrary.org/obo/PATO_0002005	concavity	http://purl.obolibrary.org/obo/PATO_0000052	shape		Surface shape that refers to the inward or outward curvature of the surface.
http://purl.obolibrary.org/obo/PATO_0002006	2-D shape	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity.
http://purl.obolibrary.org/obo/PATO_0002007	convex 3-D shape	http://purl.obolibrary.org/obo/PATO_0002266	3-D shape		A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave.
http://purl.obolibrary.org/obo/PATO_0002008	concave 3-D shape	http://purl.obolibrary.org/obo/PATO_0002266	3-D shape		A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave.
http://purl.obolibrary.org/obo/PATO_0002009	branchiness	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity.
http://purl.obolibrary.org/obo/PATO_0002011	neoplastic	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells.
http://purl.obolibrary.org/obo/PATO_0002014	structure, cavities	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas.
http://purl.obolibrary.org/obo/PATO_0002021	conical	http://purl.obolibrary.org/obo/PATO_0002007	convex 3-D shape		A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a cone (a 3-D shape with a round cross section that tapers).
http://purl.obolibrary.org/obo/PATO_0002026	non-progressive	http://purl.obolibrary.org/obo/PATO_0000057	occurrence		A quality of a single process inhering in a bearer by virtue of the bearer's not increasing over time.
http://purl.obolibrary.org/obo/PATO_0002034	undivided	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's being unseparated into parts or divisions.
http://purl.obolibrary.org/obo/PATO_0002037	degeneration	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer exhibiting deterioration of its structure.
http://purl.obolibrary.org/obo/PATO_0002039	biconcave	http://purl.obolibrary.org/obo/PATO_0001857	concave		A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces.
http://purl.obolibrary.org/obo/PATO_0002040	biconvex	http://purl.obolibrary.org/obo/PATO_0001355	convex		A shape quality inhering in a bearer by virtue of the bearer's being convex on both sides or surface.
http://purl.obolibrary.org/obo/PATO_0002041	anterior-posterior diameter	http://purl.obolibrary.org/obo/PATO_0001334	diameter		A diameter that is along the anterior-posterior axis.
http://purl.obolibrary.org/obo/PATO_0002042	decreased anterior-posterior diameter	http://purl.obolibrary.org/obo/PATO_0002041	anterior-posterior diameter		An anterior-posterior diameter quality which is relatively small.
http://purl.obolibrary.org/obo/PATO_0002043	increased anterior-posterior diameter	http://purl.obolibrary.org/obo/PATO_0002041	anterior-posterior diameter		An anterior-posterior diameter quality which is relatively large.
http://purl.obolibrary.org/obo/PATO_0002044	trapezoid	http://purl.obolibrary.org/obo/PATO_0001988	quadrangular		A shape quality inhering in a bearer by virtue of the bearer's being a quadrilateral with two parallel sides.
http://purl.obolibrary.org/obo/PATO_0002045	dendritic	http://purl.obolibrary.org/obo/PATO_0000402	branched		A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure.
http://purl.obolibrary.org/obo/PATO_0002049	lateral and rotional curvature	http://purl.obolibrary.org/obo/PATO_0001787	rotational curvature		A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis and towards the side.
http://purl.obolibrary.org/obo/PATO_0002051	increased occurrence	http://purl.obolibrary.org/obo/PATO_0002304	increased process quality		An occurrence which is relatively high.
http://purl.obolibrary.org/obo/PATO_0002052	decreased occurrence	http://purl.obolibrary.org/obo/PATO_0002302	decreased process quality		An occurrence which is relatively low.
http://purl.obolibrary.org/obo/PATO_0002055	increased fragility	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A fragility which is relatively high.
http://purl.obolibrary.org/obo/PATO_0002056	decreased fragility	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A fragility which is relatively low.
http://purl.obolibrary.org/obo/PATO_0002064	fenestrated	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structure quality inhering in a bearer by virtue of the bearer's delimited by a surface with holes.
http://purl.obolibrary.org/obo/PATO_0002076	movement behavioral quality	http://purl.obolibrary.org/obo/PATO_0000186	behavioral quality		A behavioral quality inhering in a bearer by virtue of the bearer's movement.
http://purl.obolibrary.org/obo/PATO_0002078	hollow	http://purl.obolibrary.org/obo/PATO_0002014	structure, cavities		A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within.
http://purl.obolibrary.org/obo/PATO_0002083	altered number of	http://purl.obolibrary.org/obo/PATO_0001555	has number of		Having extra or fewer parts.
http://purl.obolibrary.org/obo/PATO_0002087	bullet-shaped	http://purl.obolibrary.org/obo/PATO_0002007	convex 3-D shape		A quality inhering in a bearer by virtue of the bearer's being short and wide and tapered distally.
http://purl.obolibrary.org/obo/PATO_0002089	polycystic	http://purl.obolibrary.org/obo/PATO_0001673	cystic		A structure quality inhering in a bearer by virtue of the bearer's body containing more than one cyst - formations of sac-like closed membranous structures not associated with neoplasia.
http://purl.obolibrary.org/obo/PATO_0002093	ballooning	http://purl.obolibrary.org/obo/PATO_0000595	increased volume		A volume quality inhering in a degenerating cell by virtue of the bearer's exhibiting an increase in volume associated with cytoplasmic abnormalities.
http://purl.obolibrary.org/obo/PATO_0002094	basophilic	http://purl.obolibrary.org/obo/PATO_0070045	anatomical histological quality		An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions.
http://purl.obolibrary.org/obo/PATO_0002096	neoplastic, non-malignant	http://purl.obolibrary.org/obo/PATO_0002011	neoplastic		A disposition inhering in a tumour by virtue of the bearer's disposition not to progress, invade surrounding tissues or metastasize.
http://purl.obolibrary.org/obo/PATO_0002097	neoplastic, malignant	http://purl.obolibrary.org/obo/PATO_0002011	neoplastic		A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize.
http://purl.obolibrary.org/obo/PATO_0002112	perforate	http://purl.obolibrary.org/obo/PATO_0002014	structure, cavities		A structural quality inhering in a bearer by virtue of the bearer's having a hole or holes, especially a row or array of small holes.
http://purl.obolibrary.org/obo/PATO_0002118	multiple	http://purl.obolibrary.org/obo/PATO_0000470	increased amount		A quality inhering in a bearer by virtue of the bearer's being present in more than two copies.
http://purl.obolibrary.org/obo/PATO_0002124	laminar	http://purl.obolibrary.org/obo/PATO_0000141	structure		A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer.
http://purl.obolibrary.org/obo/PATO_0002135	delayed closure	http://purl.obolibrary.org/obo/PATO_0000502	delayed		A duration quality of a process inhering in a bearer by virtue of the bearer's delay to complete the closure of the opening of an anatomical entity.
http://purl.obolibrary.org/obo/PATO_0002141	irregular density	http://purl.obolibrary.org/obo/PATO_0001019	mass density		A density quality which lacks pattern.
http://purl.obolibrary.org/obo/PATO_0002149	ivory	http://purl.obolibrary.org/obo/PATO_0001788	increased mass density		A quality inhering in a bearer by virtue of the bearer exhibiting increased density resulting in exhibiting increased degree of radiopacity (in X-rays).
http://purl.obolibrary.org/obo/PATO_0002154	splayed ventral	http://purl.obolibrary.org/obo/PATO_0001785	splayed		A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards the abdomen of an organism.
http://purl.obolibrary.org/obo/PATO_0002155	medially rotated	http://purl.obolibrary.org/obo/PATO_0001599	rotated		A rotation quality inhering in a bearer by virtue of being rotated towards the middle of an organism.
http://purl.obolibrary.org/obo/PATO_0002156	laterally rotated	http://purl.obolibrary.org/obo/PATO_0001599	rotated		A rotation quality inhering in a bearer by virtue of being rotated towards the side of an organism.
http://purl.obolibrary.org/obo/PATO_0002157	partially dislocated	http://purl.obolibrary.org/obo/PATO_0001852	dislocated		A positional quality inhering in a bearer by virtue of the bearer's being slightly out of its usual or proper place, or position.
http://purl.obolibrary.org/obo/PATO_0002161	bicornuate	http://purl.obolibrary.org/obo/PATO_0002008	concave 3-D shape		Having two horns or horn-shaped branches.
http://purl.obolibrary.org/obo/PATO_0002162	high-arched	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch of an increased apical height.
http://purl.obolibrary.org/obo/PATO_0002163	herniated into	http://purl.obolibrary.org/obo/PATO_0001645	protruding into		A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it into the surface or boundary of another entity.
http://purl.obolibrary.org/obo/PATO_0002165	drooping	http://purl.obolibrary.org/obo/PATO_0000052	shape		To bent or hang downwards.
http://purl.obolibrary.org/obo/PATO_0002166	premature closure	http://purl.obolibrary.org/obo/PATO_0000694	premature		A duration quality of a process inhering in a bearer by virtue of the bearer's premature completion of the closure of the opening of an anatomical entity.
http://purl.obolibrary.org/obo/PATO_0002169	split medially	http://purl.obolibrary.org/obo/PATO_0001786	split		A shape quality inhering in a bearer by virtue of the bearer's being split along the median axis.
http://purl.obolibrary.org/obo/PATO_0002175	spatial deviation	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		A spatial quality inhering in a bearer by virtue of the bearer's changed direction of position towards another entity.
http://purl.obolibrary.org/obo/PATO_0002176	deviation towards the lateral side	http://purl.obolibrary.org/obo/PATO_0002175	spatial deviation		A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the side.
http://purl.obolibrary.org/obo/PATO_0002177	deviation towards the medial side	http://purl.obolibrary.org/obo/PATO_0002175	spatial deviation		A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the middle.
http://purl.obolibrary.org/obo/PATO_0002179	mislocalised proximally	http://purl.obolibrary.org/obo/PATO_0000628	mislocalised		A positional quality inhering in a bearer by virtue of the bearer's being positioned towards to point of attachment or origin.
http://purl.obolibrary.org/obo/PATO_0002180	straight	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's being free of curves, bends, or angles.
http://purl.obolibrary.org/obo/PATO_0002181	displaced	http://purl.obolibrary.org/obo/PATO_0000140	position		A positional quality inhering in a bearer by virtue the bearer's being changed in position.
http://purl.obolibrary.org/obo/PATO_0002198	quality of a substance	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality inhering in a bearer by virtue of its constitution.
http://purl.obolibrary.org/obo/PATO_0002212	slender	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape quality inhering in a bearer by virtue of the bearer's being small or narrow in circumference or width in proportion to length or height.
http://purl.obolibrary.org/obo/PATO_0002254	flattened	http://purl.obolibrary.org/obo/PATO_0001591	curvature		A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane.
http://purl.obolibrary.org/obo/PATO_0002255	grooved	http://purl.obolibrary.org/obo/PATO_0000150	texture		Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels.
http://purl.obolibrary.org/obo/PATO_0002257	multicuspidate	http://purl.obolibrary.org/obo/PATO_0001973	cuspidate		A cuscpidate quality inhering in a bearer by virtue of the bearer possessing more than one cusp.
http://purl.obolibrary.org/obo/PATO_0002265	behavioural activity	http://purl.obolibrary.org/obo/PATO_0000186	behavioral quality		A behavioral quality of a process inhering in a bearer by virtue of the bearer's disposition to exhibit marked activity.
http://purl.obolibrary.org/obo/PATO_0002266	3-D shape	http://purl.obolibrary.org/obo/PATO_0000052	shape		A shape that inheres in a 3 dimensional entity.
http://purl.obolibrary.org/obo/PATO_0002269	accumulation	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality of the collection or massing of one physical object within another physical object.
http://purl.obolibrary.org/obo/PATO_0002270	increased accumulation	http://purl.obolibrary.org/obo/PATO_0002269	accumulation		An increased number of physical objects that are accumulated within another physical object usually as a result of a failure to break down or remove objects in a timely manner.
http://purl.obolibrary.org/obo/PATO_0002281	biscupidate	http://purl.obolibrary.org/obo/PATO_0002257	multicuspidate		A cuscpidate quality inhering in a bearer by virtue of the bearer possessing two cusps.
http://purl.obolibrary.org/obo/PATO_0002282	increased mobility	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A mobility which is relative high.
http://purl.obolibrary.org/obo/PATO_0002283	decreased mobility	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A mobility which is relative low.
http://purl.obolibrary.org/obo/PATO_0002287	increased elasticity	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		An elasticity which is relatively high.
http://purl.obolibrary.org/obo/PATO_0002288	decreased elasticity	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		An elasticity which is relatively low.
http://purl.obolibrary.org/obo/PATO_0002290	aplastic/hypoplastic	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		Decreased size or absence of organ, tissue or cell due to a reduction in cell numbers.
http://purl.obolibrary.org/obo/PATO_0002291	agenesis	http://purl.obolibrary.org/obo/PATO_0040060	absence of anatomical entity		Absence of a tissue or organ due to failure to develop.
http://purl.obolibrary.org/obo/PATO_0002297	decreased cellular motility	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A cellular motility which is lower relative to the normal or average.
http://purl.obolibrary.org/obo/PATO_0002298	increased cellular motility	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		A cellular motility which is higher relative to the normal or average.
http://purl.obolibrary.org/obo/PATO_0002299	tubular	http://purl.obolibrary.org/obo/PATO_0002078	hollow		A cylindrical shape that is hollow.
http://purl.obolibrary.org/obo/PATO_0002300	increased quality	http://purl.obolibrary.org/obo/PATO_0000069	deviation (from_normal)		A quality that has a value that is increased compared to normal or average.
http://purl.obolibrary.org/obo/PATO_0002301	decreased quality	http://purl.obolibrary.org/obo/PATO_0000069	deviation (from_normal)		A quality that has a value that is decreased compared to normal or average.
http://purl.obolibrary.org/obo/PATO_0002302	decreased process quality	http://purl.obolibrary.org/obo/PATO_0002301	decreased quality		A quality of a process that has a value that is decreased compared to normal or average.
http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality	http://purl.obolibrary.org/obo/PATO_0002301	decreased quality		A quality of an object that has a value that is decreased compared to normal or average.
http://purl.obolibrary.org/obo/PATO_0002304	increased process quality	http://purl.obolibrary.org/obo/PATO_0002300	increased quality		A quality of a process that has a value that is increased compared to normal or average.
http://purl.obolibrary.org/obo/PATO_0002305	increased object quality	http://purl.obolibrary.org/obo/PATO_0002300	increased quality		A quality of an object that has a value that is increased compared to normal or average.
http://purl.obolibrary.org/obo/PATO_0002317	parallelogram	http://purl.obolibrary.org/obo/PATO_0001988	quadrangular		A convex quadrilateral is a parallelogram if and only if any one of the following statements are true:
1. Each diagonal divides the quadrilateral into two congruent triangles with the same orientation.
2. The opposite sides are congruent in pairs.
3. The diagonals bisect each other.
4. The opposite angles are congruent in pairs.
5. The sum of the squares of the sides equals the sum of the squares of the diagonals. (This is the parallelogram law)
6.It possesses rotational symmetry.
7.One pair of opposite sides are parallel and congruent.
8.Two pairs of adjacent angles are supplementary.
http://purl.obolibrary.org/obo/PATO_0002318	superelliptic	http://purl.obolibrary.org/obo/PATO_0002006	2-D shape		A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt
http://purl.obolibrary.org/obo/PATO_0002323	temporal distribution quality	http://purl.obolibrary.org/obo/PATO_0002062	physical quality of a process		A temporal distribution pattern of process occurrences within a regulation/reference process.
http://purl.obolibrary.org/obo/PATO_0002324	offset quality	http://purl.obolibrary.org/obo/PATO_0002323	temporal distribution quality		The temporal relation between the end of the process with respect to a reference process.
http://purl.obolibrary.org/obo/PATO_0002325	onset quality	http://purl.obolibrary.org/obo/PATO_0002323	temporal distribution quality		The temporal relation between the start of the process with respect to a reference process.
http://purl.obolibrary.org/obo/PATO_0002326	angle	http://purl.obolibrary.org/obo/PATO_0000133	orientation		An orientation inhering in a bearer by virtue of the bearer's placement at an angle.
http://purl.obolibrary.org/obo/PATO_0002327	increased angle to	http://purl.obolibrary.org/obo/PATO_0002326	angle		An angle which is relatively high.
http://purl.obolibrary.org/obo/PATO_0002328	decreased angle to	http://purl.obolibrary.org/obo/PATO_0002326	angle		An angle which is relatively low.
http://purl.obolibrary.org/obo/PATO_0002358	ridged	http://purl.obolibrary.org/obo/PATO_0000052	shape		An elongated raised margin or border.
http://purl.obolibrary.org/obo/PATO_0002359	broad	http://purl.obolibrary.org/obo/PATO_0000052	shape		A quality inhering in a bearer by virtue of the bearer's width being notably higher than its length.
http://purl.obolibrary.org/obo/PATO_0002400	fusiform	http://purl.obolibrary.org/obo/PATO_0001409	spindle-shaped		Having a spindle-like shape that is wide in the middle and tapers at both ends.
http://purl.obolibrary.org/obo/PATO_0002403	generalized	http://purl.obolibrary.org/obo/PATO_0000060	spatial pattern		Affecting all regions without specificity of distribution.
http://purl.obolibrary.org/obo/PATO_0002418	acidophilic	http://purl.obolibrary.org/obo/PATO_0070045	anatomical histological quality		An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions.
http://purl.obolibrary.org/obo/PATO_0002422	acinar	http://purl.obolibrary.org/obo/PATO_0000141	structure		Pertaining to the individual parts making up an aggregate fruit like a many-lobed "berry," such as a raspberry.
http://purl.obolibrary.org/obo/PATO_0002444	mineralized	http://purl.obolibrary.org/obo/PATO_0000025	composition		A composition quality inhering in a bearer by virtue of the bearer's being composed of or possessing inorganic material.
http://purl.obolibrary.org/obo/PATO_0002462	collagenous	http://purl.obolibrary.org/obo/PATO_0000025	composition		A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen.
http://purl.obolibrary.org/obo/PATO_0002468	distensible	http://purl.obolibrary.org/obo/PATO_0015008	distensibility		A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching.
http://purl.obolibrary.org/obo/PATO_0002478	transversely striated	http://purl.obolibrary.org/obo/PATO_0001410	striated		A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer.
http://purl.obolibrary.org/obo/PATO_0002505	nucleated	http://purl.obolibrary.org/obo/PATO_0001404	nucleate quality		A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus.
http://purl.obolibrary.org/obo/PATO_0002507	keratinous	http://purl.obolibrary.org/obo/PATO_0000025	composition		A composition quality inhering in a bearer by virtue of the bearer's consisting of keratin.
http://purl.obolibrary.org/obo/PATO_0002519	cancellous	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's having an open, latticed, or porous structure; used especially of bone.
http://purl.obolibrary.org/obo/PATO_0005013	incomplete structure	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in a bearer by virtue of the bearer's lacking parts or having a reduced form compared to fully formed entities.
http://purl.obolibrary.org/obo/PATO_0005021	unicuspidate	http://purl.obolibrary.org/obo/PATO_0001973	cuspidate		Cuspidate quality inhering in a bearer by virtue of the bearer's possessing a single cusp.
http://purl.obolibrary.org/obo/PATO_0010001	disconnected	http://purl.obolibrary.org/obo/PATO_0000141	structure		A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other.
http://purl.obolibrary.org/obo/PATO_0015001	absence due to degeneration	http://purl.obolibrary.org/obo/PATO_0040060	absence of anatomical entity		Absence due to a degenerative process.
http://purl.obolibrary.org/obo/PATO_0015007	prominence	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A quality inhering in a bearer by virtue of the degree to which the bearers stands out or projects beyond a surface or line.
http://purl.obolibrary.org/obo/PATO_0015008	distensibility	http://purl.obolibrary.org/obo/PATO_0000141	structure		A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen.
http://purl.obolibrary.org/obo/HP_3000068	Abnormality of lateral pterygoid muscle	http://purl.obolibrary.org/obo/HP_0410011	Abnormality of masticatory muscle		An abnormality of a lateral pterygoid muscle.
http://purl.obolibrary.org/obo/UBERON_0034948	carbon dioxide in respiratory system	http://purl.obolibrary.org/obo/UBERON_0034947	gas in respiratory system		Any portion of gas located in a part of the respiratory system that is composed primarily of carbon dioxide.
http://purl.obolibrary.org/obo/UBERON_0035038	carpal tunnel	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		The fibro-osseous passageway on the palmar side of the wrist that connects the distal forearm to the middle compartment of the deep plane of the palm.
http://purl.obolibrary.org/obo/UBERON_0035091	extrinsic post-anal tail muscle	http://purl.obolibrary.org/obo/UBERON_0003665	post-anal tail muscle		A post-anal tail that attaches outside the tail.
http://purl.obolibrary.org/obo/UBERON_0035097	iliocaudalis muscle	http://purl.obolibrary.org/obo/UBERON_0035091	extrinsic post-anal tail muscle		A muscle that attaches to the iliac crest and to a caudal vertebra.
http://purl.obolibrary.org/obo/UBERON_0035110	lateral plantar nerve	http://purl.obolibrary.org/obo/UBERON_0035109	plantar nerve		A plantar nerve that supplies the lateral side of the plantar part of the foot, including pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0035111	medial plantar nerve	http://purl.obolibrary.org/obo/UBERON_0035109	plantar nerve		A plantar nerve that supplies the medial side of the plantar part of the foot, including pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0035119	diastema between incisors	http://purl.obolibrary.org/obo/UBERON_0012111	diastema		A space or gap any two incisors. This may be a midline diastema between central incisors, or a diastema located entirely in a single jaw quadrant between lateral incisors.
http://purl.obolibrary.org/obo/UBERON_0035165	posterior surface of prostate	http://purl.obolibrary.org/obo/UBERON_0035480	surface of prostate		The flattened aspect of the prostate with a slight furrow facing the rectum and anus.
http://purl.obolibrary.org/obo/UBERON_0035403	hypophysial artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies the pituitary gland.
http://purl.obolibrary.org/obo/UBERON_0035435	right suprarenal vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A vein that drains blood from the right adrenal gland into the inferior vena cava.
http://purl.obolibrary.org/obo/UBERON_0035480	surface of prostate	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		The external portion of the prostate including the anterior, inferolateral, lateral and posterior surfaces.
http://purl.obolibrary.org/obo/UBERON_0035483	left suprarenal vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A vein that drains blood from the left adrenal gland into the left renal artery.
http://purl.obolibrary.org/obo/UBERON_0035523	anterior surface of prostate	http://purl.obolibrary.org/obo/UBERON_0035480	surface of prostate		The aspect of the prostate facing the pubic symphysis.
http://purl.obolibrary.org/obo/UBERON_0035539	esophageal artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		Any of several arteries that arise from the aorta and supply blood to the esophagus.
http://purl.obolibrary.org/obo/UBERON_0035608	dura mater lymph vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		Any lymph vessel that is located in the dura mater of the brain.
http://purl.obolibrary.org/obo/UBERON_0035649	nerve of penis	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		Any nerve that innervates the penis.
http://purl.obolibrary.org/obo/UBERON_0035650	nerve of clitoris	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		Any nerve that innervates the clitoris.
http://purl.obolibrary.org/obo/UBERON_0035815	paracardial fat	http://purl.obolibrary.org/obo/UBERON_0035814	pericardial fat		Fat deposits in the mediastinum outside the parietal pericardium .
http://purl.obolibrary.org/obo/UBERON_0035825	left adrenal gland cortex	http://purl.obolibrary.org/obo/UBERON_0001235	adrenal cortex		The thick outer layer of the adrenal gland that is in the left side of the abdomen.
http://purl.obolibrary.org/obo/UBERON_0035826	left adrenal gland medulla	http://purl.obolibrary.org/obo/UBERON_0001236	adrenal medulla		The adrenal gland medulla that is in the left side of the abdomen.
http://purl.obolibrary.org/obo/UBERON_0035827	right adrenal gland cortex	http://purl.obolibrary.org/obo/UBERON_0001235	adrenal cortex		The thick outer layer of the adrenal gland that is in the right side of the abdomen.
http://purl.obolibrary.org/obo/UBERON_0035828	right adrenal gland medulla	http://purl.obolibrary.org/obo/UBERON_0001236	adrenal medulla		The adrenal gland medulla that is in the right side of the abdomen.
http://purl.obolibrary.org/obo/UBERON_0035879	frontomaxillary suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		A suture between the frontal bone and the frontal process of the maxilla.
http://purl.obolibrary.org/obo/UBERON_0035881	ethmoidomaxillary suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		A suture between the orbital surface of the body of the maxilla with the orbital plate of the ethmoid bone.
http://purl.obolibrary.org/obo/UBERON_0035882	sphenomaxillary suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		An inconstant suture between the pterygoid process of the sphenoid bone and the body of the maxilla.
http://purl.obolibrary.org/obo/UBERON_0035883	lacrimomaxillary suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		A suture between the lacrimal bone and the maxilla.
http://purl.obolibrary.org/obo/UBERON_0035884	maxillary-premaxillary suture	http://purl.obolibrary.org/obo/UBERON_2002260	premaxillary-maxillary joint		A suture between the maxilla and premaxilla.
http://purl.obolibrary.org/obo/UBERON_0035956	epididymal lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The lumen of the epididymis.
http://purl.obolibrary.org/obo/UBERON_0036013	intergluteal cleft	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		The line that divided the gluteal regions of the body.
http://purl.obolibrary.org/obo/UBERON_0036014	gluteal sulcus	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		A horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg.
http://purl.obolibrary.org/obo/HP_0025546	Abnormal mean corpuscular hemoglobin concentration	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.
http://purl.obolibrary.org/obo/HP_0025547	Decreased mean corpuscular hemoglobin concentration	http://purl.obolibrary.org/obo/HP_0025546	Abnormal mean corpuscular hemoglobin concentration		A reduction from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.
http://purl.obolibrary.org/obo/HP_0025548	Increased mean corpuscular hemoglobin concentration	http://purl.obolibrary.org/obo/HP_0025546	Abnormal mean corpuscular hemoglobin concentration		An elevation over the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell).
http://purl.obolibrary.org/obo/HP_0025549	Eccentric visual fixation	http://purl.obolibrary.org/obo/HP_0025404	Abnormal visual fixation		A uniocular condition in which there is fixation of an object by a point other than the fovea. This point adopts the principal visual direction. The degree of the eccentric fixation is defined by its distance from the fovea in degrees.
http://purl.obolibrary.org/obo/HP_0025551	Optic nerve misrouting	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		Abnormal decussation of the visual pathways, typically identified using visual evoked potentials (VEP) (asymmetrical distribution of the VEP over the posterior scalp).
http://purl.obolibrary.org/obo/HP_0025552	Periorbital purpura	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Multiple red/purple spots on the skin that surrounds the eyes that do not blanch (whiten) upon pressure. Purpura is caused by subcutaneous bleeding.
http://purl.obolibrary.org/obo/HP_0025553	Periorbital ecchymosis with tarsal plate sparing	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Subcutaneous bleeding with a diameter greater than 1 cm (ecchymosis). The bleeding does not extend into the tarsal plate (the comparatively thick, elongated plates of dense connective tissue within the eyelid) due to an anatomic structure called the orbital septum, which limits extravasation of blood beyond the tarsal plate.
http://purl.obolibrary.org/obo/HP_0025554	Yellow nodule	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		A type of skin nodule (a lesions that is greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat) with a yellowish coloration (that reflects a high lipid content of the lesion).
http://purl.obolibrary.org/obo/HP_0025555	Periungual teleangiectasia	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		Telangiectasia (small dilated blood vessels) located near to the fingernails or toenails.
http://purl.obolibrary.org/obo/HP_0031111	Cutaneous hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A hamartoma (tissue malformation consisting of an abnormal mixture of constitutive components) originating in the skin.
http://purl.obolibrary.org/obo/HP_0031207	Hepatic hemangioma	http://purl.obolibrary.org/obo/HP_0410266	Visceral hemangioma		A congenital vascular malformation in the liver composed of masses of blood vessels that are atypical or irregular in arrangement and size.
http://purl.obolibrary.org/obo/HP_0031208	Increased pituitary glycoprotein hormone alpha subunit level	http://purl.obolibrary.org/obo/HP_0032481	Abnormal pituitary glycoprotein hormone alpha subunit level		An increased concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081). This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones.
http://purl.obolibrary.org/obo/HP_0031209	Decreased circulating lipoprotein lipase concentration	http://purl.obolibrary.org/obo/HP_0033477	Abnormal circulating lipoprotein lipase concentration		Reduction in the level of lipoprotein lipase in the blood.
http://purl.obolibrary.org/obo/HP_0031210	Abnormal circulating hyaluronic acid concentration	http://purl.obolibrary.org/obo/HP_0011012	Abnormal circulating polysaccharide concentration		A deviation from the normal concentration of hyaluronic acid in the blood.
http://purl.obolibrary.org/obo/HP_0031211	Elevated cholesterol ester level	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		An elevated concentration of circulating cholesterol esters, which are fatty acid esters of cholesterol and make up about two-thirds of total plasma cholesterol.
http://purl.obolibrary.org/obo/HP_0031213	Elevated circulating 17-hydroxyprogesterone concentration	http://purl.obolibrary.org/obo/HP_0031216	Increased circulating progesterone		An increased level of 17-hydroxyprogesterone in the blood. 17-hydroxyprogesterone is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase.
http://purl.obolibrary.org/obo/HP_0031215	Decreased circulating dehydroepiandrosterone-sulfate concentration	http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level		A reduced concentration of dehydroepiandrosterone-sulfate in the blood.
http://purl.obolibrary.org/obo/HP_0031216	Increased circulating progesterone	http://purl.obolibrary.org/obo/HP_0031212	Abnormal circulating progesterone level		An elevated concentration of progesterone in the blood.
http://purl.obolibrary.org/obo/HP_0031217	Hot flashes	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Sudden feelings of warmth that are generally most pronounced over the face, neck and chest.
http://purl.obolibrary.org/obo/HP_0031218	Inappropriate antidiuretic hormone secretion	http://purl.obolibrary.org/obo/HP_0031072	Abnormal endocrine physiology		A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume.
http://purl.obolibrary.org/obo/HP_0031219	Reduced radioactive iodine uptake	http://purl.obolibrary.org/obo/HP_0031221	Abnormal radioactive iodine uptake test result		A decreased amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.
http://purl.obolibrary.org/obo/HP_0031220	Increased radioactive iodine uptake	http://purl.obolibrary.org/obo/HP_0031221	Abnormal radioactive iodine uptake test result		An elevated amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.
http://purl.obolibrary.org/obo/HP_0031221	Abnormal radioactive iodine uptake test result	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		Any deviation from normal in the amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.
http://purl.obolibrary.org/obo/HP_0031222	Elevated circulating thyroxine-binding globulin concentration	http://purl.obolibrary.org/obo/HP_0034590	Abnormal circulating thyroxine-binding globulin concentration		The concentration of thyroxine-binding globulin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031223	Focal pancreatic islet hyperplasia	http://purl.obolibrary.org/obo/HP_0004510	Pancreatic islet-cell hyperplasia		Hyperplasia of the islets of Langerhans that affects only certain regions of the pancreas and not others.
http://purl.obolibrary.org/obo/HP_0031224	Diffuse pancreatic islet hyperplasia	http://purl.obolibrary.org/obo/HP_0004510	Pancreatic islet-cell hyperplasia		Hyperplasia of the islets of Langerhans with a generalized distribution.
http://purl.obolibrary.org/obo/HP_0031225	Intrapulmonary shunt	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		Blood flow through a region of the lung in which little or no ventilation takes place, resulting in reduced oxygenation of the blood leaving the lungs.
http://purl.obolibrary.org/obo/HP_0031226	Perinephric fluid collection	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An accumulation of fluid in one or more of the perinephric spaces, which consist of the subcapsular, perirenal, anterior and posterior pararenal spaces. This abnormality can be demonstrated by cross-sectional imaging, particularly computed tomography.
http://purl.obolibrary.org/obo/HP_0031227	Nasopharyngeal teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		A teratoma arising in the nasopharyngeal region.
http://purl.obolibrary.org/obo/HP_0031228	Abnormal incisura morphology	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		An abnormal shape of the incisura, defined as the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by the antitragus, and along its lower lateral margins and inferior boundary by the connection between the first two. The upper boundary is a somewhat arbitrary line crossing from the apices of the antitragus and the tragus.
http://purl.obolibrary.org/obo/HP_0031229	Increased incisura length	http://purl.obolibrary.org/obo/HP_0031228	Abnormal incisura morphology		The length of the incisura from the upper to lower border is greater than that observed in the average population.
http://purl.obolibrary.org/obo/HP_0031230	Decreased incisura length	http://purl.obolibrary.org/obo/HP_0031228	Abnormal incisura morphology		The length of the incisura from the upper to lower border is less than that observed in the average population.
http://purl.obolibrary.org/obo/HP_0031231	Narrow incisura width	http://purl.obolibrary.org/obo/HP_0031228	Abnormal incisura morphology		Width of the incisura from the anterior to posterior border less than that observed in the average population.
http://purl.obolibrary.org/obo/HP_0031232	Increased incisura width	http://purl.obolibrary.org/obo/HP_0031228	Abnormal incisura morphology		Breadth of the incisura from the anterior to posterior border greater than that observed in the average population.
http://purl.obolibrary.org/obo/HP_0031233	Horizontal inferior border of scapula	http://purl.obolibrary.org/obo/HP_0000782	Abnormal scapula morphology		A morphological abnormality of the scapula in which there is a flat (horizontal) inferior edge of the scapula. The entire scapula is said to resemble a square, leading to the designation sqaring of the scapula (in Figure 1 of PMID:24706940 the scapulae have a roughly rectangular shape).
http://purl.obolibrary.org/obo/HP_0031234	Neutrophilic infiltration of the skin	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		A predominantly neutrophilic infiltrate of the dermis and or epidermis (i.e., a large number of neutrophils inferred to have migrated into the skin).
http://purl.obolibrary.org/obo/HP_0031235	Predominantly epidermal neutrophilic infiltrate	http://purl.obolibrary.org/obo/HP_0031234	Neutrophilic infiltration of the skin		Collection of neutrophils in the epidermis.
http://purl.obolibrary.org/obo/HP_0031236	Predominantly dermal neutrophilic infiltrate	http://purl.obolibrary.org/obo/HP_0031234	Neutrophilic infiltration of the skin		Collection of neutrophils in the dermis.
http://purl.obolibrary.org/obo/HP_0031237	Internally nucleated skeletal muscle fibers	http://purl.obolibrary.org/obo/HP_0020201	Abnormal sarcomere morphology		An abnormally increased proportion of nuclei of sarcomeres with an internal localization. Individual muscle fibers are syncytia, formed by embryonic fusion of many myoblasts or later, myosatellite cells. Each muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5% of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei.
http://purl.obolibrary.org/obo/HP_0031238	Necklace skeletal muscle fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		A histological alteration of muscle fibers that resembles a necklace (necklace fibers). A substantial proportion of fibers (4-20% in PMID:19084976) show internalized nuclei aligned in a basophilic ring (necklace) at 3 micrometers beneath the sarcolemma. Ultrastructurally, such necklaces consist of myofibrils of smaller diameter, in oblique orientation, surrounded by mitochondria, sarcoplasmic reticulum and glycogen granules.
http://purl.obolibrary.org/obo/HP_0031239	Extrafoveal choroidal neovascularization	http://purl.obolibrary.org/obo/HP_0011506	Choroidal neovascularization		A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 200 to 1500 micrometers from the center of the fovea.
http://purl.obolibrary.org/obo/HP_0031240	Juxtafoveal choroidal neovascularization	http://purl.obolibrary.org/obo/HP_0030495	Abnormal macular vasculature morphology		A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 1 to 199 micrometers from the center of the fovea.
http://purl.obolibrary.org/obo/HP_0031241	Subfoveal choroidal neovascularization	http://purl.obolibrary.org/obo/HP_0030495	Abnormal macular vasculature morphology		A type of choroidal neovascularization in which the area of neovascularization overlaps with the center of the fovea.
http://purl.obolibrary.org/obo/HP_0031242	Decreased circulating chylomicron concentration	http://purl.obolibrary.org/obo/HP_0031887	Abnormal chylomicron concentration		Reduced plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins.
http://purl.obolibrary.org/obo/HP_0031243	Decreased circulating VLDL-C concentration	http://purl.obolibrary.org/obo/HP_0031889	Abnormal circulating VLDL-C concentration		The concentration of very-low-density lipoprotein cholesterol in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031244	Swollen lip	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Enlargement of the lip typically due to fluid buildup or inflammation.
http://purl.obolibrary.org/obo/HP_0031245	Productive cough	http://purl.obolibrary.org/obo/HP_0012735	Cough		A cough that produces phlegm or mucus.
http://purl.obolibrary.org/obo/HP_0031246	Nonproductive cough	http://purl.obolibrary.org/obo/HP_0012735	Cough		A cough that does not produce phlegm or mucus.
http://purl.obolibrary.org/obo/HP_0031247	Whooping cough	http://purl.obolibrary.org/obo/HP_0012735	Cough		A type of cough characterized by a burst of numerous and rapid coughs followed by a long inhaling effort that is accompanied by a high-pitched whooping sound produced by the inhalation of air.
http://purl.obolibrary.org/obo/HP_0031248	Palmar pruritus	http://purl.obolibrary.org/obo/HP_0030899	Pruritis on hand		Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the palm(s) of the hand.
http://purl.obolibrary.org/obo/HP_0031249	Parageusia	http://purl.obolibrary.org/obo/HP_0000223	Abnormality of taste sensation		A distortion of the sense of taste, often characterized by the sensation of a metallic taste.
http://purl.obolibrary.org/obo/HP_0031250	Lip fissure	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		A severe crack in a lip. A lip fissure may be painful, may bleed and often is a recurring manifestation.
http://purl.obolibrary.org/obo/HP_0031251	Abnormal subclavian artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any anomaly of a subclavian artery.
http://purl.obolibrary.org/obo/HP_0031252	Dilated left subclavian artery	http://purl.obolibrary.org/obo/HP_0031251	Abnormal subclavian artery morphology		Abnormally increased caliber of the left subclavian artery.
http://purl.obolibrary.org/obo/HP_0031253	Anomalous origin of left subclavian artery	http://purl.obolibrary.org/obo/HP_0031251	Abnormal subclavian artery morphology		Origin of the left subclavian artery from an anomalous anatomical location.
http://purl.obolibrary.org/obo/HP_0031254	Thalamic arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the thalamus.
http://purl.obolibrary.org/obo/HP_0031255	Hypothalamic arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0012286	Abnormal hypothalamus morphology		An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the hypothalamus.
http://purl.obolibrary.org/obo/HP_0031256	Optic nerve arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the optic nerve.
http://purl.obolibrary.org/obo/HP_0031257	Arteriovenous malformation of the maxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the maxilla.
http://purl.obolibrary.org/obo/HP_0031258	Delirium	http://purl.obolibrary.org/obo/HP_0001289	Confusion		A state of sudden and severe confusion.
http://purl.obolibrary.org/obo/HP_0031259	Oophoritis	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		An inflammation of the ovary or ovaries.
http://purl.obolibrary.org/obo/HP_0031260	Triangular tibia	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		A short, dysplastic tibia with a triangular shape. Instead of the normal shaft configuration of the tibia, the tibia forms a triangle with the longest side corresponding to the proximal-distal dimension, and the apex of the triangle directed laterally.
http://purl.obolibrary.org/obo/HP_0031261	Bladder polyp	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		An abnormal growth that projects from the mucous membrane of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0031264	Abnormal Bowman capsule morphology	http://purl.obolibrary.org/obo/HP_0031263	Abnormal renal corpuscle morphology		A structural anomaly of the double-walled capsule (Bowman capsule) that opens into a renal tubule.
http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology	http://purl.obolibrary.org/obo/HP_0031264	Abnormal Bowman capsule morphology		Any structural anomaly of the podocyte, which is a highly specialized cell of the Bowman capsule and which forms multiple interdigitating foot processes. Podocytes are interconnected by slit diaphragms and cover the exterior basement membrane surface of the glomerular capillary.
http://purl.obolibrary.org/obo/HP_0031266	Podocyte foot process effacement	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		An anomaly of podocyte morphology characterized by the loss of the interdigitating foot process pattern (generally called foot process effacement; FPE). The term FPE designates the loss of the usual interdigitating pattern of foot processes of neighboring podocytes, leading to relatively broad expanses of podocyte processes covering the glomerular basement membrane (GBM). It is widely viewed as a pathological derangement that is associated with leakage of macromolecules such as albumin through the glomerular filtration barrier.
http://purl.obolibrary.org/obo/HP_0031267	Abnormal CD69 upregulation upon TCR activation	http://purl.obolibrary.org/obo/HP_0410035	Abnormal T cell activation		Any abnormality in the upregulation of CD69 on T cells after activation via the T cell receptor (TCR). Upregulation of CD69 is one of the earliest and most sensitive measures of antigen recognition in the periphery, and transient expression of CD69 is associated with positive selection in the thymus.
http://purl.obolibrary.org/obo/HP_0031268	Decreased CD69 upregulation upon TCR activation	http://purl.obolibrary.org/obo/HP_0031267	Abnormal CD69 upregulation upon TCR activation		Reduced or impaired upregulation of CD69 on T cells after activation via the T cell receptor (TCR).
http://purl.obolibrary.org/obo/HP_0031269	Abnormal CD25 upregulation upon TCR activation	http://purl.obolibrary.org/obo/HP_0410035	Abnormal T cell activation		Any abnormality in the upregulation of CD25 on T cells after activation via the T cell receptor (TCR). CD25 is the alpha chain of the IL2 receptor. Ligation of the T cell antigen receptor leads to the induction of CD25 expression.
http://purl.obolibrary.org/obo/HP_0031270	Decreased CD25 upregulation upon TCR activation	http://purl.obolibrary.org/obo/HP_0031269	Abnormal CD25 upregulation upon TCR activation		Decreased or impaired upregulation of CD25 on T cells after activation via the T cell receptor (TCR).
http://purl.obolibrary.org/obo/HP_0031271	Absent ankle pulse	http://purl.obolibrary.org/obo/HP_0032554	Absent pulse		The pulsation of the posterior tibial artery behind the internal malleolus, or of the dorsalis pedis artery, cannot be detected on physical examination.
http://purl.obolibrary.org/obo/HP_0031272	Pulmonary arterial atherosclerosis	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Accumulation of lipids and inflammatory cells along the inner walls of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0031273	Shock	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.
http://purl.obolibrary.org/obo/HP_0031274	Hypovolemic shock	http://purl.obolibrary.org/obo/HP_0031273	Shock		A state of shock characterized by decreased circulating blood volume in relation to total vascular capacity. This type of shock is characterized by a reduction of diastolic filling pressures.
http://purl.obolibrary.org/obo/HP_0031275	Distributive shock	http://purl.obolibrary.org/obo/HP_0031273	Shock		A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage
http://purl.obolibrary.org/obo/HP_0031276	Obstructive shock	http://purl.obolibrary.org/obo/HP_0031273	Shock		A type of shock characterized by inadequate cardiac preload due to obstructed venous return (e.g. pericardial tamponade, tension pneumothorax, abdominal compartment) or obstruction of arterial blood flow (e.g. pulmonary embolism).
http://purl.obolibrary.org/obo/HP_0031278	Abnormal thoracic duct morphology	http://purl.obolibrary.org/obo/HP_0100766	Abnormal lymphatic vessel morphology		Any structural anomaly of the thoracic duct.
http://purl.obolibrary.org/obo/HP_0031279	Abnormal response to gonadotropin-releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		An abnormal response to the gonadotropin-releasing hormone (GnRH) stimulation test. This test typically involves intravenous administration of GnRH followed by repeated blood sampling at various time points to measure the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
http://purl.obolibrary.org/obo/HP_0031280	Increased LH response to gonadotropin-releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0031279	Abnormal response to gonadotropin-releasing hormone stimulation test		An abnormally high amount of luteinizing hormone (LH) is released upon gonadotropin-releasing hormone stimulation test.
http://purl.obolibrary.org/obo/HP_0031281	Sialadenitis	http://purl.obolibrary.org/obo/HP_0010286	Abnormal salivary gland morphology		Inflammation of a salivary gland.
http://purl.obolibrary.org/obo/HP_0031282	Malalignment of the great toenail	http://purl.obolibrary.org/obo/HP_0008388	Abnormal toenail morphology		A lateral deviation of the nail plate of the great toe along the longitudinal axis due to the lateral rotation of the nail matrix. The nail plate grows out in ridges.
http://purl.obolibrary.org/obo/HP_0031283	Tufted hairs	http://purl.obolibrary.org/obo/HP_0011360	Acquired abnormal hair pattern		The presence of tufts of 8-15 hairs that appear to emerge from a single follicular orifice.
http://purl.obolibrary.org/obo/HP_0031286	Perifollicular erythema	http://purl.obolibrary.org/obo/HP_0031285	Abnormal perifollicular morphology		Redness surrounding the hair follicles.
http://purl.obolibrary.org/obo/HP_0031287	Seborrheic keratosis	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		A raised growth on the skin of older individuals. The lesion usually is initially light tan and may darken to dark brown or nearly black. The consistent feature of seborrheic keratoses is their waxy, pasted-on or stuck-on look.
http://purl.obolibrary.org/obo/HP_0031288	Cobblestone-like hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		The presence of verrucous, cobblestone-like papules and nodules in a region of skin that is said to have an appearance like that of cobblestones.
http://purl.obolibrary.org/obo/HP_0031289	White papule	http://purl.obolibrary.org/obo/HP_0200034	Papule		A papule with white color.
http://purl.obolibrary.org/obo/HP_0031290	Tuberous xanthoma	http://purl.obolibrary.org/obo/HP_0000991	Xanthomatosis		A type of xanthoma characterized by a nodular form. Tuberous xanthomas are firm subcutaneous nodules,whereby the overlying skin can have red or red-yellow color changes.
http://purl.obolibrary.org/obo/HP_0031291	Ichthyosis follicularis	http://purl.obolibrary.org/obo/HP_0008064	Ichthyosis		Ichthyosis follicularis is characterized by widespread non inflammatory thorn-like follicular projections. Dyskeratotic papules are most pronounced over the extensor extremities and scalp and are symmetrically distributed.
http://purl.obolibrary.org/obo/HP_0031293	Digital pitting scar	http://purl.obolibrary.org/obo/HP_0100276	Skin pit		Pinhole-sized concave depressions with hyperkeratosis in the skin of a finger or toe.
http://purl.obolibrary.org/obo/HP_0031294	Hypoplastic right atrium	http://purl.obolibrary.org/obo/HP_0025580	Abnormal right atrium morphology		Underdeveloped, small right heart atrium.
http://purl.obolibrary.org/obo/HP_0031295	Left atrial enlargement	http://purl.obolibrary.org/obo/HP_0025579	Abnormal left atrium morphology		Increase in size of the left atrium.
http://purl.obolibrary.org/obo/HP_0031296	Atrial septal hypertrophy	http://purl.obolibrary.org/obo/HP_0005120	Abnormal cardiac atrium morphology		An abnormal increase in the thickness of the atrial septum.
http://purl.obolibrary.org/obo/HP_0031298	Coronary sinus enlargement	http://purl.obolibrary.org/obo/HP_0011642	Abnormal coronary sinus morphology		Abnormal increase in size of the coronary sinus.
http://purl.obolibrary.org/obo/HP_0031299	Elevated left atrial pressure	http://purl.obolibrary.org/obo/HP_0025443	Abnormal cardiac atrial physiology		An abnormal increase in magnitude of the pressure in the left atrium.
http://purl.obolibrary.org/obo/HP_0031300	Abnormal circulating properdin concentration	http://purl.obolibrary.org/obo/HP_0025465	Abnormal circulating beta globulin concentration		Any deviation from the normal concentration of properdin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031301	Peripheral arterial calcification	http://purl.obolibrary.org/obo/HP_0003207	Arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall.
http://purl.obolibrary.org/obo/HP_0031302	Lower extremity peripheral arterial calcification	http://purl.obolibrary.org/obo/HP_0031301	Peripheral arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the leg.
http://purl.obolibrary.org/obo/HP_0031303	Femoral arterial calcification	http://purl.obolibrary.org/obo/HP_0035012	Abnormal femoral artery morphology		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the femoral artery.
http://purl.obolibrary.org/obo/HP_0031304	Iliac arterial calcification	http://purl.obolibrary.org/obo/HP_4000066	Abnormal iliac artery morphology		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the iliac artery.
http://purl.obolibrary.org/obo/HP_0031305	Tibial arterial calcification	http://purl.obolibrary.org/obo/HP_0031302	Lower extremity peripheral arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the tibial artery.
http://purl.obolibrary.org/obo/HP_0031307	Internal carotid artery calcification	http://purl.obolibrary.org/obo/HP_0031306	Intracranial arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the internal carotid artery.
http://purl.obolibrary.org/obo/HP_0031308	Vertebral artery calcification	http://purl.obolibrary.org/obo/HP_0030321	Abnormal vertebral artery morphology		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the vertebral artery.
http://purl.obolibrary.org/obo/HP_0031309	Cerebral artery calcification	http://purl.obolibrary.org/obo/HP_0031306	Intracranial arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a cerebral artery.
http://purl.obolibrary.org/obo/HP_0031310	Basilar artery calcification	http://purl.obolibrary.org/obo/HP_0031306	Intracranial arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the basilar artery.
http://purl.obolibrary.org/obo/HP_0031311	Middle cerebral artery calcification	http://purl.obolibrary.org/obo/HP_0031309	Cerebral artery calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the middle cerebral artery.
http://purl.obolibrary.org/obo/HP_0031313	Abdominal aortic calcification	http://purl.obolibrary.org/obo/HP_0004963	Calcification of the aorta		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in abdominal aorta.
http://purl.obolibrary.org/obo/HP_0031314	Carotid artery calcification	http://purl.obolibrary.org/obo/HP_0003207	Arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a carotid artery.
http://purl.obolibrary.org/obo/HP_0031315	External carotid artery calcification	http://purl.obolibrary.org/obo/HP_0031314	Carotid artery calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the external carotid artery.
http://purl.obolibrary.org/obo/HP_0031316	Abnormal ventricular myocardium morphology	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		A structural anomaly of the muscle layer of the heart wall of a cardiac ventricle.
http://purl.obolibrary.org/obo/HP_0031317	Fatty replacement of ventricular myocardial tissue	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Presence of an increased amount of fat tissue within a cardiac ventricle with corresponding reduction of muscle tissue.
http://purl.obolibrary.org/obo/HP_0031318	Myofiber disarray	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		A nonparallel arrangement of cardiac myocytes.
http://purl.obolibrary.org/obo/HP_0031319	Cardiomyocyte hypertrophy	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		An increase in cell size, enhanced protein synthesis, and heightened organization of the sarcomere within cardiac myocytes.
http://purl.obolibrary.org/obo/HP_0031320	Cardiomyocyte mitochondrial proliferation	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		An abnormal increase in the number of mitochondria per cardiac myocyte.
http://purl.obolibrary.org/obo/HP_0031321	Myocardial immune cell infiltration	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		An increase in the number of immune cells in myocardial tissue (which can be assumed to have migrated into the myocardium).
http://purl.obolibrary.org/obo/HP_0031322	Myocardial lymphocytic infiltration	http://purl.obolibrary.org/obo/HP_0031321	Myocardial immune cell infiltration		An increase in the number of lymphocytes in myocardial tissue.
http://purl.obolibrary.org/obo/HP_0031323	Myocardial eosinophilic infiltration	http://purl.obolibrary.org/obo/HP_0031321	Myocardial immune cell infiltration		An increase in the number of eosinophils in myocardial tissue.
http://purl.obolibrary.org/obo/HP_0031324	Myocardial multinucleated giant cells	http://purl.obolibrary.org/obo/HP_0031321	Myocardial immune cell infiltration		The presence of extremely large cells with multiple nuclei. The so-called giant cells are thought to be of macrophage origin.
http://purl.obolibrary.org/obo/HP_0031325	Myocardial granulomatous infiltrates	http://purl.obolibrary.org/obo/HP_0031321	Myocardial immune cell infiltration		The presence of multiple granulomata (small nodular inflammatory lesions containing grouped mononuclear phagocytes) in the myocardium.
http://purl.obolibrary.org/obo/HP_0031326	Monoclonal light chain cardiac amyloidosis	http://purl.obolibrary.org/obo/HP_0030843	Cardiac amyloidosis		A type of cardiac amyloidosis related to deposition of an immunoglobulin light chain. The current gold standard of amyloid typing is to determine the precursor protein using laser microdissection mass spectrometry.
http://purl.obolibrary.org/obo/HP_0031327	Cardiac transthyretin amyloid deposition	http://purl.obolibrary.org/obo/HP_0030843	Cardiac amyloidosis		A type of cardiac amyloidosis related to deposition of transthyretin (TTR), which is identified by immunohistochemical staining.
http://purl.obolibrary.org/obo/HP_0031328	Perivascular cardiac fibrosis	http://purl.obolibrary.org/obo/HP_0032200	Perivascular fibrosis		A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in perivascular spaces.
http://purl.obolibrary.org/obo/HP_0031329	Interstitial cardiac fibrosis	http://purl.obolibrary.org/obo/HP_0001685	Myocardial fibrosis		A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in interstitial spaces.
http://purl.obolibrary.org/obo/HP_0031330	Perivascular myocardial immune cell infiltration	http://purl.obolibrary.org/obo/HP_0031321	Myocardial immune cell infiltration		An increase in the number of immune cells in myocardial tissue concentrated in the spaces surrounding blood vessels.
http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		Any structural anomaly of cardiomyocytes, which are terminally differentiated muscle cells in the heart that are interconnected end to end by gap junctions, which allows coordinated contraction of heart tissue.
http://purl.obolibrary.org/obo/HP_0031332	Cardiomyocyte degeneration	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		Deterioration of cardiomyocyte characterized by abnormal features such as loss of myofilaments, occurrence of cellular sequestration, decreased mitochondrial sizes and cellular debris.
http://purl.obolibrary.org/obo/HP_0031333	Myocardial sarcomeric disarray	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		A disruption of the structure of the sarcomeres of cardiomyocytes. The sarcomere is the repeating unit between two Z lines comprised largely of myosin and actin that mediates contractility, and normally sarcomeres are aligned with the long axis of cells, with the Z bands being in register throughout the length of the cardiac myocytes.
http://purl.obolibrary.org/obo/HP_0031334	Cardiomyocyte inclusion bodies	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		Nuclear or cytoplasmic aggregates of stainable substances within cardiomyocytes.
http://purl.obolibrary.org/obo/HP_0031335	Abnormal cardiomyocyte mitochondrial morphology	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		An anomaly of the structure of mitochondria within cardiomyocytes.
http://purl.obolibrary.org/obo/HP_0031336	Intranuclear cardiomyocyte mitochondria	http://purl.obolibrary.org/obo/HP_0031335	Abnormal cardiomyocyte mitochondrial morphology		Abnormal localization of mitochondria within the nuclei of cardiomyocytes.
http://purl.obolibrary.org/obo/HP_0031337	Abnormal cardiomyocyte connexin43 staining	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		Anomalous staining of Connexin43 in cardiomyocytes. Connexin43 (Cx43) is the primary gap junction protein in the working myocardium. Cx43 exhibits increased localization at the lateral membranes of cardiomyocytes in a variety of heart diseases.
http://purl.obolibrary.org/obo/HP_0031338	Abnormal cardiomyocyte plakoglobin staining	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		Anomalous staining of plakoglobin in cardiomyocytes. Plakoglobin is a component of desmosomes in cardiomyocytes.
http://purl.obolibrary.org/obo/HP_0031339	Abnormal cardiomyocyte dystrophin staining	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		Anomalous staining of dystrophin in cardiomyocytes.
http://purl.obolibrary.org/obo/HP_0031340	Abnormal lysosomal morphology	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		A structural anomaly of lysosomes, membrane-enclosed organelles that contain an array of enzymes capable of catabolizing proteins, nucleic acids, carbohydrates, and lipids.
http://purl.obolibrary.org/obo/HP_0031341	Gastric arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0002629	Gastrointestinal arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the stomach.
http://purl.obolibrary.org/obo/HP_0031342	Duodenal arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0002629	Gastrointestinal arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the duodenum.
http://purl.obolibrary.org/obo/HP_0031343	Jejunal arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0002629	Gastrointestinal arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the jejunum.
http://purl.obolibrary.org/obo/HP_0031344	Pelvic arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the pelvis.
http://purl.obolibrary.org/obo/HP_0031345	Colonic arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0002629	Gastrointestinal arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the colon.
http://purl.obolibrary.org/obo/HP_0031346	Rectal arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0002629	Gastrointestinal arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the rectum.
http://purl.obolibrary.org/obo/HP_0031347	Uterine arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the uterus.
http://purl.obolibrary.org/obo/HP_0031348	Dextrotransposition of the great arteries	http://purl.obolibrary.org/obo/HP_0001669	Transposition of the great arteries		A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the right of the pulmonary artery. This is the most common kind of TGA.
http://purl.obolibrary.org/obo/HP_0031350	Cardiac sarcoma	http://purl.obolibrary.org/obo/HP_0100544	Neoplasm of the heart		A malignant soft tissue neoplasm that arises from the heart.
http://purl.obolibrary.org/obo/HP_0031351	Calcified amorphous tumor of the heart	http://purl.obolibrary.org/obo/HP_0100544	Neoplasm of the heart		A non-neoplastic cardiac tumor characterized by calcification and eosinophilic amorphous material in the background of dense collagenous fibrous tissue.
http://purl.obolibrary.org/obo/HP_0031352	Chest tightness	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		An unpleasant sensation of tightness or pressure in the chest.
http://purl.obolibrary.org/obo/HP_0031353	Otitis media with effusion	http://purl.obolibrary.org/obo/HP_0000388	Otitis media		Otitis media characterized by thick or sticky fluid behind the tympanic membrane.
http://purl.obolibrary.org/obo/HP_0031354	Sleep onset insomnia	http://purl.obolibrary.org/obo/HP_0100785	Insomnia		Difficulty initiating sleep, that is, increased sleep onset latency, refers to the condition where it takes 30 minutes or more to fall asleep.
http://purl.obolibrary.org/obo/HP_0031355	Maintenance insomnia	http://purl.obolibrary.org/obo/HP_0100785	Insomnia		Individuals affected by abnormal difficulty in staying asleep tend to wake up at night and struggle to return to sleep. This condition typically involves spending more than 30 minutes awake during the night.
http://purl.obolibrary.org/obo/HP_0031356	Terminal insomnia	http://purl.obolibrary.org/obo/HP_0100785	Insomnia		Waking up earlier than intended and being unable to return to sleep.
http://purl.obolibrary.org/obo/HP_0031357	Glomeruloid hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A histologically distinctive, cutaneous, benign vascular tumor that is characterized by a solitary or multiple blue-red papules and histologically resembles renal glomeruli.
http://purl.obolibrary.org/obo/HP_0031358	Vegetative state	http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness		The absence of wakefulness and consciousness, but in contrast to a coma, there is involuntary opening of the eyes and movements such as teeth grinding, yawning, or thrashing of the extremities.
http://purl.obolibrary.org/obo/HP_0031359	Cutaneous sclerotic plaque	http://purl.obolibrary.org/obo/HP_0200035	Skin plaque		A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter that is characterized by hardening (sclerosis) of the affected skin area (related to collagen thickening).
http://purl.obolibrary.org/obo/HP_0031360	Yellow skin plaque	http://purl.obolibrary.org/obo/HP_0200035	Skin plaque		A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter and that has a yellow color.
http://purl.obolibrary.org/obo/HP_0031361	Zebra bodies	http://purl.obolibrary.org/obo/HP_0031340	Abnormal lysosomal morphology		Intralysosomal, osmiophilic, lamellated and sometimes concentric cytoplasmic inclusions comprised of broad transversely-stacked myelinoid membranes and said to resemble a zebra in electron microscopic images.
http://purl.obolibrary.org/obo/HP_0031363	Palpable purpura	http://purl.obolibrary.org/obo/HP_0000979	Purpura		A type of purpura in which the lesions are raised (and can therefore be appreciated upon palpation).
http://purl.obolibrary.org/obo/HP_0031364	Ecchymosis	http://purl.obolibrary.org/obo/HP_0031365	Macular purpura		A purpuric lesion that is larger than 1 cm in diameter.
http://purl.obolibrary.org/obo/HP_0031366	Palate neoplasm	http://purl.obolibrary.org/obo/HP_0100649	Neoplasm of the oral cavity		A neoplasm that affects the hard palate, soft palate, or uvula.
http://purl.obolibrary.org/obo/HP_0031368	Intestinal perforation	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		A hole (perforation) in the wall of the intestine.
http://purl.obolibrary.org/obo/HP_0031369	Colon perforation	http://purl.obolibrary.org/obo/HP_0031368	Intestinal perforation		A hole (perforation) in the wall of the colon.
http://purl.obolibrary.org/obo/HP_0031370	Small intestinal perforation	http://purl.obolibrary.org/obo/HP_0031368	Intestinal perforation		A hole (perforation) in the wall of the small intestine.
http://purl.obolibrary.org/obo/HP_0031371	Rectal perforation	http://purl.obolibrary.org/obo/HP_0031368	Intestinal perforation		A hole (perforation) in the wall of the rectum.
http://purl.obolibrary.org/obo/HP_0031372	Cold paresis	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Increased muscle weakness upon exposure to cold temperatures.
http://purl.obolibrary.org/obo/HP_0031373	Stiff tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Increased rigidity and reduced mobility of the tongue.
http://purl.obolibrary.org/obo/HP_0031374	Ankle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Reduced strength of the muscles that lift or otherwise move the foot at the ankle.
http://purl.obolibrary.org/obo/HP_0031375	Refractory	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		Applies to a sign or symptom that is difficult to treat or cure.
http://purl.obolibrary.org/obo/HP_0031377	Abnormal cell proliferation	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		Any abnormality in the multiplication or reproduction of cells, which may result in the expansion of a cell population.
http://purl.obolibrary.org/obo/HP_0031378	Abnormal lymphocyte proliferation	http://purl.obolibrary.org/obo/HP_0031409	Abnormal lymphocyte physiology		Any abnormality in the multiplication or reproduction of lymphocytes, which results in the expansion of a cell population.
http://purl.obolibrary.org/obo/HP_0031379	Abnormal T cell proliferation	http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology		Any abnormality in the multiplication or reproduction of T cells, which results in the expansion of a cell population.
http://purl.obolibrary.org/obo/HP_0031380	Abnormal B cell proliferation	http://purl.obolibrary.org/obo/HP_0031378	Abnormal lymphocyte proliferation		Any abnormality in the multiplication or reproduction of B cells, which results in the expansion of a cell population.
http://purl.obolibrary.org/obo/HP_0031381	Decreased mitogen-induced T-cell proliferation	http://purl.obolibrary.org/obo/HP_0031379	Abnormal T cell proliferation		Abnormal decrease of T cell proliferation in response to mitogenic stimuli. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation, specific stimulus and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0031382	Decreased anti-CD3/28-induced T-cell proliferation	http://purl.obolibrary.org/obo/HP_0031381	Decreased mitogen-induced T-cell proliferation		Abnormal decrease of T cell proliferation in response to anti-CD3/28 stimulation. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0031384	Reduced T cell CD40 expression	http://purl.obolibrary.org/obo/HP_0031383	Abnormal lymphocyte surface marker expression		A deficiency in the expression of the CD40 ligand on the surface of activated T-lymphocytes.
http://purl.obolibrary.org/obo/HP_0031385	Megakaryocyte nucleus hypolobulation	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		The presence of megakaryocytes in the bone marrow whose nuclei are less lobulated than expected for the size of the nucleus.
http://purl.obolibrary.org/obo/HP_0031386	Increased micromegakaryocyte count	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		The presence of abnormally high numbers of micromegakaryocytes in the bone marrow. Micromegakaryocytes are mononuclear diploid cells, with a nucleus similar in size to that of a myeloblast or promyelocyte with the cell being less than 30 micrometers in diameter.
http://purl.obolibrary.org/obo/HP_0031387	Increased multinucleated megakaryocyte count	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		The presence of abnormally high numbers of multinucleated megakaryocytes in the bone marrow.
http://purl.obolibrary.org/obo/HP_0031388	Megakaryocyte nucleus hyperlobulation	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		The presence of megakaryocytes in the bone marrow whose nuclei are more lobulated than expected for the size of the nucleus.
http://purl.obolibrary.org/obo/HP_0031389	Abnormal MHC II cell surface expression	http://purl.obolibrary.org/obo/HP_6001190	Abnormal MHC surface expression		A deviation from the normal level of major histocompatibility complex class II molecules expressed at the cell surface.
http://purl.obolibrary.org/obo/HP_0031390	Reduced MHC II cell surface expression	http://purl.obolibrary.org/obo/HP_0031389	Abnormal MHC II cell surface expression		Expression of major histocompatibility complex class II molecules at the cell surface is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031391	Elevated MHC II cell surface expression	http://purl.obolibrary.org/obo/HP_0031389	Abnormal MHC II cell surface expression		An increase above the normal level of major histocompatibility complex class II molecules expressed at the cell surface.
http://purl.obolibrary.org/obo/HP_0031392	Abnormal CD4+ T cell subset proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Abnormal increase or decrease of any CD4+ T cell subpopulation, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0031393	Abnormal total CD8+ T cell number	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Abnormal increase or decrease of the absolute number of cytotoxic CD3+CD8+ T cells (measured the absolute count per volume or as percentage of total CD3+ T cells in the blood), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0031394	Abnormal CD4:CD8 ratio	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Any abnormality in the relative amount of CD4+ and CD8+ T lymphocytes.
http://purl.obolibrary.org/obo/HP_0031396	Abnormal naive T cell proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Any abnormality in the proportion of naive T cells relative to the total number of T cells.
http://purl.obolibrary.org/obo/HP_0031397	Decreased naive T cell proportion	http://purl.obolibrary.org/obo/HP_0031396	Abnormal naive T cell proportion		An abnormally decreased proportion of naive T cells relative to the total number of T cells.
http://purl.obolibrary.org/obo/HP_0031398	Increased naive T cell proportion	http://purl.obolibrary.org/obo/HP_0031396	Abnormal naive T cell proportion		An abnormally increased proportion of naive T cells relative to the total number of T cells.
http://purl.obolibrary.org/obo/HP_0031401	Decreased double-negative T cell number	http://purl.obolibrary.org/obo/HP_0031399	Abnormal double-negative T cell proportion		Abnormal decrease of double negative (DN) CD3+CD4-CD8- T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0031402	Decreased antigen-specific T cell proliferation	http://purl.obolibrary.org/obo/HP_0031404	Impaired antigen-specific response		Impaired proliferation and expansion of a T cell population following activation by an antigenic stimulus.
http://purl.obolibrary.org/obo/HP_0031403	Impaired pathogen-specific CD8 cytoxicity	http://purl.obolibrary.org/obo/HP_0031404	Impaired antigen-specific response		Impaired response of CD8 T cells to pathogens. CD8 T cells direct the killing of a target cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
http://purl.obolibrary.org/obo/HP_0031404	Impaired antigen-specific response	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		An impaired immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
http://purl.obolibrary.org/obo/HP_0031405	Poroma	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures [NCIT:C27273].
http://purl.obolibrary.org/obo/HP_0031406	Abnormal cytokine signaling	http://purl.obolibrary.org/obo/HP_0011111	Abnormal immune serum protein physiology		Any abnormality in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
http://purl.obolibrary.org/obo/HP_0031407	Impaired cytokine signaling	http://purl.obolibrary.org/obo/HP_0031406	Abnormal cytokine signaling		A defect or impairment in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
http://purl.obolibrary.org/obo/HP_0031408	Increased CD25+ mast cell proportion	http://purl.obolibrary.org/obo/HP_0100494	Abnormal mast cell morphology		An increased proportion of mast cells are positive for the cell surface marker CD25 (also called interleukin-2 receptor alpha chain).
http://purl.obolibrary.org/obo/HP_0031409	Abnormal lymphocyte physiology	http://purl.obolibrary.org/obo/HP_0033796	Abnormal leukocyte physiology		Any anomaly of lymphocyte function.
http://purl.obolibrary.org/obo/HP_0031410	Abnormal distribution of CD56 bright/dim natural killer cells	http://purl.obolibrary.org/obo/HP_0500033	Abnormal natural killer subset distribution		An abnormal distribution in the number of CD56 bright NK cells, as measured by flow cytometry. CD56, an adhesion molecule mediating homotypic adhesion, is used as a functional marker for NK cells.
http://purl.obolibrary.org/obo/HP_0031411	Abnormal chromosome morphology	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		Any structural anomaly of a chromosome, which is a thread like molecule consisting of DNA and proteins (chromatin) that contains DNA sequences for genes and other genetic elements in linear order.
http://purl.obolibrary.org/obo/HP_0031413	Short telomere length	http://purl.obolibrary.org/obo/HP_0031412	Abnormal telomere morphology		An abnormal reduction in telomere length. Telomeres are non-coding, repetitive sequences of DNA at the ends of the chromosomes of eukaryotic cells which become shorter as cells divide, and when telomere attrition reaches its limit, cell proliferation arrest, senescence, and apoptosis can occur.
http://purl.obolibrary.org/obo/HP_0031414	Elevated circulating calcifediol concentration	http://purl.obolibrary.org/obo/HP_0100511	Abnormal circulating vitamin D concentration		The concentration of calcifediol in the blood concentration is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031415	Elevated circulating calcitriol concentration	http://purl.obolibrary.org/obo/HP_0100511	Abnormal circulating vitamin D concentration		The concentration of calcitriol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031416	Abnormal nasal mucus secretion	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Any deviation from the normal quantity of secretion of nasal mucus, a thick viscous liquid produced by the mucous membranes of the nose.
http://purl.obolibrary.org/obo/HP_0031417	Rhinorrhea	http://purl.obolibrary.org/obo/HP_0031416	Abnormal nasal mucus secretion		Increased discharge of mucus from the nose.
http://purl.obolibrary.org/obo/HP_0031418	Increased body mass index	http://purl.obolibrary.org/obo/HP_0045081	Abnormality of body mass index		Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages.
http://purl.obolibrary.org/obo/HP_0031419	Decreased circulating sex hormone-binding globulin concentration	http://purl.obolibrary.org/obo/HP_0031438	Abnormal circulating sex hormone-binding globulin concentration		The concentration of sex hormone-binding globulin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031420	Small yellow/white macular lesion	http://purl.obolibrary.org/obo/HP_0030500	Yellow/white macular lesion		A lesion that is observed acutely following light damage to the macula, typically smaller than 200 micrometers. Damage to the retinal by exposure to intense visible light, usually the sun. Intense light exposure such as staring at the sun causes fine structural anomalies in the outer segments of the photoreceptors and the retinal pigment epithelium (RPE) cells of the macula. Such lesions can also be laser-induced.
http://purl.obolibrary.org/obo/HP_0031421	Small superior frontal cortex	http://purl.obolibrary.org/obo/HP_0002472	Small cerebral cortex		Reduced size of the superior frontal portion of the cerebral cortex.
http://purl.obolibrary.org/obo/HP_0031422	Abnormal cerebellar cortex morphology	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		Any structural anomaly of the cortex of the cerebellum.
http://purl.obolibrary.org/obo/HP_0031423	Small cerebellar cortex	http://purl.obolibrary.org/obo/HP_0031422	Abnormal cerebellar cortex morphology		Reduced size of the cerebellar cortex.
http://purl.obolibrary.org/obo/HP_0031424	Abnormal circulating beta-CTX concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of beta-CTX (= beta-C-terminal telopeptide, = beta-C-terminal telopeptide of type I collagen) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031425	Elevated circulating beta-CTX concentration	http://purl.obolibrary.org/obo/HP_0031424	Abnormal circulating beta-CTX concentration		The concentration of beta-CTX (= beta-C-terminal telopeptide, = beta-C-terminal telopeptide of type I collagen) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031426	Decreased circulating beta-CTX concentration	http://purl.obolibrary.org/obo/HP_0031424	Abnormal circulating beta-CTX concentration		The concentration of beta-CTX (= beta-C-terminal telopeptide, = beta-C-terminal telopeptide of type I collagen) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031427	Abnormal circulating osteocalcin level	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		A deviation from the normal concentration of osteocalcin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031428	Increased circulating osteocalcin level	http://purl.obolibrary.org/obo/HP_0031427	Abnormal circulating osteocalcin level		An elevated level of osteocalcin in the blood.
http://purl.obolibrary.org/obo/HP_0031429	Decreased circulating osteocalcin level	http://purl.obolibrary.org/obo/HP_0031427	Abnormal circulating osteocalcin level		A reduced level of osteocalcin in the blood.
http://purl.obolibrary.org/obo/HP_0031430	Oligoclonal T cell expansion	http://purl.obolibrary.org/obo/HP_0025845	Abnormal TCR repertoire		The presence of a population of T cells with a restricted T cell receptor (TCR) repertoire derived from a limited number of TCR clones.
http://purl.obolibrary.org/obo/HP_0031431	Persistent repetition of sounds	http://purl.obolibrary.org/obo/HP_4000072	Abnormal language feature		Repetition of sounds with no meaning.
http://purl.obolibrary.org/obo/HP_0031432	Restricted or repetitive behaviors or interests	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		A broad range of compulsive behaviors are repeated, including simple motor stereotypies and tics, as well as more complex repetitive movements or compulsions.
http://purl.obolibrary.org/obo/HP_0031433	Alexithymia	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		Alexithymia is characterized by an impaired ability to be aware of, explicitly identify, and describe one's feelings.
http://purl.obolibrary.org/obo/HP_0031434	Abnormal prosody	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		Prosody refers to the patterns of rhythm, stress, and intonation in spoken language. Abnormal prosody refers to abnormalities in the patterns of rhythm, stress, or intonation of speech or vocalization that can be heard by the observer. In general, this refers to overt and clear deviations in patterns from culturally accepted norms but many also include differences noted in comparison to the usual patterns of the individual (a quiet person suddenly becomes loud or vice versa).
http://purl.obolibrary.org/obo/HP_0031435	Monotonic speech	http://purl.obolibrary.org/obo/HP_5200010	Abnormal Intonation		A speech pattern characterized by a persistently abnormal lack of tone in the voice. Monotonic speech is typically ongoing, lasting throughout the day, but may have a diurnal variation in the pattern, i.e. slower at specific times of the day.
http://purl.obolibrary.org/obo/HP_0031436	Singsong Intonation	http://purl.obolibrary.org/obo/HP_5200010	Abnormal Intonation		A speech pattern characterized by abnormal fluctuations in the pitch of the voice.
http://purl.obolibrary.org/obo/HP_0031438	Abnormal circulating sex hormone-binding globulin concentration	http://purl.obolibrary.org/obo/HP_0025465	Abnormal circulating beta globulin concentration		Any deviation from the normal concentration of sex hormone-binding globulin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031439	Abnormal circulating angiostatin concentration	http://purl.obolibrary.org/obo/HP_0025465	Abnormal circulating beta globulin concentration		Any deviation from the normal concentration of angiostatin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031441	Abnormal tricuspid valve annulus morphology	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		Any structural anomaly of the annulus of the tricuspid valve. The annulus is a ring composed of fibrous and myocardial tissue and is the structure onto which the cusps of the valve attach.
http://purl.obolibrary.org/obo/HP_0031443	Abnormal tricuspid valve leaflet morphology	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		Any structural anomaly of the leaflets (also known as cusps) of the tricuspid valve.
http://purl.obolibrary.org/obo/HP_0031444	Dilatation of the tricuspid annulus	http://purl.obolibrary.org/obo/HP_0031441	Abnormal tricuspid valve annulus morphology		An increase in the diameter of the ring (annulus) of the tricuspid valve.
http://purl.obolibrary.org/obo/HP_0031445	Oral mucosa nodule	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		A palpable, solid lesion greater than 5mm in diameter that is located in the mucosa of the mouth.
http://purl.obolibrary.org/obo/HP_0031446	Erosion of oral mucosa	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		Loss of the superficial layer of the oral mucosa usually resulting in a shallow or crusted lesion.
http://purl.obolibrary.org/obo/HP_0031447	Penile freckling	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Multiple pigmented macules located on the skin of the penis.
http://purl.obolibrary.org/obo/HP_0031448	Herpetiform vesicles	http://purl.obolibrary.org/obo/HP_0200037	Skin vesicle		Multiple vesicles distributed in multiple distinct groups consisting of multiple adjacent vesicles.
http://purl.obolibrary.org/obo/HP_0031449	Perineal hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		Hemangioma, a benign tumor of the vascular endothelial cells, located in the perineal region, i.e., the region between the anus and the genitals.
http://purl.obolibrary.org/obo/HP_0031450	Polycyclic	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		A distribution of skin lesions resembling multiple merged circles. For instance, this can be seen with multiple urticarial wheals as the individual, circular wheals resolve and merge.
http://purl.obolibrary.org/obo/HP_0031451	Lower extremity subcutanous fat hypertrophy	http://purl.obolibrary.org/obo/HP_0009124	Abnormal adipose tissue morphology		An abnormal increase in the amount of subcutaneous fat in the legs.
http://purl.obolibrary.org/obo/HP_0031452	Lichenoid skin lesion	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Multiple skin lesions resembling those characteristic of the disease lichen planus. These lesions are violaceous (reddish-purple), shiny, isolated, flat-topped papules and plaques.
http://purl.obolibrary.org/obo/HP_0031453	Oral lichenoid lesion	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		Multiple lesions of the oral mucosa resembling those characteristic of the disease lichen planus. These are symmetric reticular lesions that resemble a white, lacelike network, as well as by papules, plaques, erythematous lesions, and erosions.
http://purl.obolibrary.org/obo/HP_0031454	Apocrine hidrocystoma	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		A cystic lesions that forms a benign tumor of an apocrine sweat gland.
http://purl.obolibrary.org/obo/HP_0031455	Presacral ganglioneuroma	http://purl.obolibrary.org/obo/HP_0003005	Ganglioneuroma		A gangioleneuroma originating from sympathetic ganglion cells in the abdomen.
http://purl.obolibrary.org/obo/HP_0031456	Ectopic pregnancy	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube).
http://purl.obolibrary.org/obo/HP_0031457	Pulmonary opacity	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Opacity refers to any area that preferentially attenuates the x-ray beam and therefore appears more opaque than the surrounding area. It is a nonspecific term that does not indicate the size or pathologic nature of the abnormality.
http://purl.obolibrary.org/obo/HP_0031458	Adenoiditis	http://purl.obolibrary.org/obo/HP_3000033	Abnormal nasopharyngeal adenoid morphology		An inflammation of the adenoid tissue.
http://purl.obolibrary.org/obo/HP_0031460	Benign muscle neoplasm	http://purl.obolibrary.org/obo/HP_0031459	Soft tissue neoplasm		A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle tissue [NCIT:C4882].
http://purl.obolibrary.org/obo/HP_0031461	Intramuscular myxoma	http://purl.obolibrary.org/obo/HP_0031460	Benign muscle neoplasm		A benign tumor that is usually solitary, painless, palpable mass that is firm in consistency and slightly movable and often fluctuant. It can occur in any location, but tends to involve the muscles of the thighs, buttocks, and shoulders. On microscopic examination, there is abundant mucoid material and relative hypo cellularity and loose reticulin fibers. Vascular structures are sparse. The cells have a stellate shape with small hyper chromatic pyknotic nuclei and scanty cytoplasm. Some myxomas may show focal areas of hyper cellularity. However absence of nuclear atypia, mitotic figures or necrosis helps to rule out malignancy.
http://purl.obolibrary.org/obo/HP_0031462	Musculotendinous retraction	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		Abnormal reduction in length of a tendon which tends to pull (retract) the attached muscle tissue with shortening of the muscle fibers often accompanied by atrophy and fatty degeneration of the affected muscle tissue.
http://purl.obolibrary.org/obo/HP_0031463	Esophageal squamous papilloma	http://purl.obolibrary.org/obo/HP_0100751	Esophageal neoplasm		A rare benign epithelial tumor that is usually asymptomatic but can present with pyrosis and epigastric discomfort with or without dysphagia. Histopathologically, esophageal squamous papilloma has fingerlike projections lined with acanthotic stratified squamous epithelium with conservation of normal cellular with or without cellular atypia.
http://purl.obolibrary.org/obo/HP_0031464	Genital blistering	http://purl.obolibrary.org/obo/HP_0033800	Blistering by anatomical location		The presence of one or more bullae on the skin of the genital region, defined as fluid-filled blisters more than 5 mm in diameter with thin walls.
http://purl.obolibrary.org/obo/HP_0031465	Abnormal vasa vasorum morphology	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		A structural anomaly of vasa vasorum, which are defined as small blood vessels that supply or drain the walls of larger arteries and veins, delivering nutrients and oxygen as well as removing systemic waste products.
http://purl.obolibrary.org/obo/HP_0031467	Dysregulated negative emotional state	http://purl.obolibrary.org/obo/HP_0100851	Abnormal emotional state		An emotional state characterized by excessive, persistent, or contextually inappropriate negative inner experiences involving emotional arousal and valence. These experiences are often associated with negative perceptions of the self, the future, the past, or the surrounding environment, and may include affective bias such as interpreting neutral or ambiguous stimuli as negative. The intensity, duration, or impact of the state exceeds what would be expected for the individual based on their baseline emotional functioning, the context, cultural norms, or situational triggers, or when it persists despite efforts at self-regulation.
http://purl.obolibrary.org/obo/HP_0031468	Separation insecurity	http://purl.obolibrary.org/obo/HP_0000739	Anxiety		Fears of rejection by and/or separation from significant others are associated with fears of excessive dependency and complete loss of autonomy.
http://purl.obolibrary.org/obo/HP_0031469	Low self-esteem	http://purl.obolibrary.org/obo/HP_5200242	Cognitive distortion		Persistent, excessively negative, and critical thoughts of one's personal abilities, attributes, or any feature related to the self and self-attitude. The affected individual believes they are a lesser being compared to others in their social peer group.
http://purl.obolibrary.org/obo/HP_0031472	Risky behavior	http://purl.obolibrary.org/obo/HP_0000734	Disinhibition		Engaging in dangerous, risky, and potentially self-damaging activities, without considering the consequences, and include physical, health-related, and financial behaviors. It involves a disregard for one's limitations and a denial of personal danger. While consequences may not occur, the risks are high (e.g. driving too fast, unprotected casual sex, or risky investments).
http://purl.obolibrary.org/obo/HP_0031473	Anger	http://purl.obolibrary.org/obo/HP_0031467	Dysregulated negative emotional state		A state of excessive negative emotional reactivity characterized by strong feelings of hostility or antagonism typically in response to perceived provocation. It is often accompanied by physiological arousal (e.g., increased heart rate, muscle tension, or activation of the sympathetic nervous system) and expressions of blame, perceived injustice, or judgment. The experience of anger may be directed outwardly toward individuals, groups, objects, or abstract entities, or inwardly toward oneself.
http://purl.obolibrary.org/obo/HP_0031474	Pulmonary chondroma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		A benign cartilaginous tumors of the lung.
http://purl.obolibrary.org/obo/HP_0031476	Abnormal buccal mucosa cell morphology	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		Any structural anomaly of the cells of the mucosa of the oral cavity in the region of the cheek (buccal mucosa cells).
http://purl.obolibrary.org/obo/HP_0031478	Abnormal mitral valve annulus morphology	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		Any structural anomaly of the annulus of the mitral valve. The annulus is a ring composed of fibrous and myocardial tissue and is the structure onto which the cusps of the valve attach.
http://purl.obolibrary.org/obo/HP_0031479	Dilatation of the mitral annulus	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		An increase in the diameter of the ring (annulus) of the mitral valve.
http://purl.obolibrary.org/obo/HP_0031482	Abnormal regional left ventricular contraction	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		A wall motion abnormality observed upon left ventricular contraction that affects a specific region of the left ventricle.
http://purl.obolibrary.org/obo/HP_0031483	Reduced contraction of the left ventricular apex	http://purl.obolibrary.org/obo/HP_0031482	Abnormal regional left ventricular contraction		Reduced wall motion (contraction) of the apex of the left ventricle. This manifestation can be observed on echocardiography.
http://purl.obolibrary.org/obo/HP_0031484	Cold-induced hemolysis	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		A form of hemolytic anemia that can be triggered by cold temperatures.
http://purl.obolibrary.org/obo/HP_0031485	Subperiosteal bone formation	http://purl.obolibrary.org/obo/HP_0030313	Abnormal periosteum morphology		The formation of new bone along the cortex and underneath the periosteum of a bone.
http://purl.obolibrary.org/obo/HP_0031486	Vascular malformation of the lip	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		An anomaly of blood vessels located in the lip.
http://purl.obolibrary.org/obo/HP_0031487	Capillary malformation of the lip	http://purl.obolibrary.org/obo/HP_0031486	Vascular malformation of the lip		A vascular malformation located in the lip that is characterized by ectatic papillary dermal capillaries and postcapillary venules in the upper reticular dermis.
http://purl.obolibrary.org/obo/HP_0031488	Arteriovenous malformation of the lip	http://purl.obolibrary.org/obo/HP_0031486	Vascular malformation of the lip		A vascular malformation located in the lip that is characterized by direct blood shunting from an artery to a vein due to the absence of a capillary bed. The artery and vein can be directly connected by a fistula or indirectly connected by an abnormal vessel channel termed a nidus.
http://purl.obolibrary.org/obo/HP_0031489	Venous malformation of the lip	http://purl.obolibrary.org/obo/HP_0031486	Vascular malformation of the lip		A vascular malformation located in the lip that is related to abnormal vascular morphogenesis.
http://purl.obolibrary.org/obo/HP_0031490	Hemangioma of the lip	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A vascular malformation located in the lip that is related to vascular endothelial cell hyperplasia.
http://purl.obolibrary.org/obo/HP_0031491	Continuous spike and waves during slow sleep	http://purl.obolibrary.org/obo/HP_0025373	Interictal EEG abnormality		Diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep.
http://purl.obolibrary.org/obo/HP_0031492	Epithelial neoplasm	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas [NCIT:C3709].
http://purl.obolibrary.org/obo/HP_0031493	Glandular cell neoplasm	http://purl.obolibrary.org/obo/HP_0031492	Epithelial neoplasm		A tumor that arises from a gland cell.
http://purl.obolibrary.org/obo/HP_0031494	Ovarian mucinous tumor	http://purl.obolibrary.org/obo/HP_0031495	Mucinous neoplasm		Ovarian mucinous neoplasms consist of borderline tumors (tumors of low malignant potential, or LMP tumors), intraepithelial (non-invasive) carcinoma, and invasive carcinoma.
http://purl.obolibrary.org/obo/HP_0031496	Mucinous cystic neoplasm of the pancreas	http://purl.obolibrary.org/obo/HP_0031495	Mucinous neoplasm		Mucin-producing and septated cyst-forming epithelial neoplasia of the pancreas with a distinctive ovarian-type stroma.
http://purl.obolibrary.org/obo/HP_0031497	Mucinous colorectal carcinoma	http://purl.obolibrary.org/obo/HP_0031495	Mucinous neoplasm		A subtype of colorectal carcinoma with mucin lakes.
http://purl.obolibrary.org/obo/HP_0031498	Mucinous gastric carcinoma	http://purl.obolibrary.org/obo/HP_0031495	Mucinous neoplasm		A poorly differentiated type of gastric carcinoma with a substantial amount of extracellular mucus (over 50% of tumor volume) within the tumor.
http://purl.obolibrary.org/obo/HP_0031499	Appendiceal mucinous neoplasm	http://purl.obolibrary.org/obo/HP_0031495	Mucinous neoplasm		An epithelial neoplasm originating in the appendix and often associated with cystic dilation of the appendix due to accumulation of gelatinous material, morphologically referred to as mucoceles.
http://purl.obolibrary.org/obo/HP_0031500	Abdominal mass	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		An abnormal enlargement or swelling in the abdomen.
http://purl.obolibrary.org/obo/HP_0031501	Pelvic mass	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		An abnormal enlargement or swelling in the pelvic region.
http://purl.obolibrary.org/obo/HP_0031502	Trophoblastic tumor	http://purl.obolibrary.org/obo/HP_0100728	Germ cell neoplasia		A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells [NCIT:C3422].
http://purl.obolibrary.org/obo/HP_0031503	Night gasping	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Waking up at night gasping for breath.
http://purl.obolibrary.org/obo/HP_0031504	Foamy urine	http://purl.obolibrary.org/obo/HP_0033072	Abnormal macroscopic urine appearance		Urine has an increased amount of frothy fine bubbles.
http://purl.obolibrary.org/obo/HP_0031505	Abnormal circulating T4 concentration	http://purl.obolibrary.org/obo/HP_0031508	Abnormal circulating thyroid hormone concentration		A deviation from the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).
http://purl.obolibrary.org/obo/HP_0031506	Increased circulating T4 concentration	http://purl.obolibrary.org/obo/HP_0031505	Abnormal circulating T4 concentration		An elevation above the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).
http://purl.obolibrary.org/obo/HP_0031507	Decreased circulating T4 concentration	http://purl.obolibrary.org/obo/HP_0031505	Abnormal circulating T4 concentration		A reduction below the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).
http://purl.obolibrary.org/obo/HP_0031509	Dry nipple	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		Abnormally dry skin in the area of the nipple of the breast.
http://purl.obolibrary.org/obo/HP_0031510	Linear earlobe crease	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		A transverse linear fissure (crease) in the lobule of the ear.
http://purl.obolibrary.org/obo/HP_0031511	Diagonal earlobe crease	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Diagonal earlobe creases run from the lower pole of the external meatus, diagonally backwards to the edge of the lobe at approximately 45 degrees.
http://purl.obolibrary.org/obo/HP_0031513	Luse bodies	http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology		Fusiform collagen fibers with abnormally long spacing (exceeding 100 nm) between electron-dense bands.
http://purl.obolibrary.org/obo/HP_0031514	Increased exhausted T cell proportion	http://purl.obolibrary.org/obo/HP_0041080	Abnormal exhausted T cell proportion		An abnormally elevated proportion of exhausted T cells (Tex) among circulating T cells. T cell exhaustion is a distinct differentiation state that can be distinguished from naive, effector, and memory T cells. Compared to effector (TE) and memory (TMEM) T cells, exhausted T cells (TEX) display impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity). TEX have limited proliferative potential, especially compared to some subsets of TMEM and naive T cells.
http://purl.obolibrary.org/obo/HP_0031515	Abnormal meiosis	http://purl.obolibrary.org/obo/HP_0033337	Abnormal gametogenesis		Any anomaly of meiosis, a type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells.
http://purl.obolibrary.org/obo/HP_0031516	Metaphase I oocyte maturation arrest	http://purl.obolibrary.org/obo/HP_0034914	Oocyte maturation arrest		Failure of oocytes to proceed through the stages of meiosis with stoppage at the first metaphase stage.
http://purl.obolibrary.org/obo/HP_0031517	Verruciform xanthoma	http://purl.obolibrary.org/obo/HP_0000991	Xanthomatosis		A papillary or cauliflower-like growth characterized by the presence of foamy histiocytes within the elongated dermal papillae forms.
http://purl.obolibrary.org/obo/HP_0031518	Absent posterior alpha rhythm	http://purl.obolibrary.org/obo/HP_0025373	Interictal EEG abnormality		Lack of normal alpha rhythm in the EEG. Alpha rhythm has been defined as a rhythm at 8-13 Hz occurring during wakefulness over the posterior regions of the head, generally with higher voltage over the occipital areas. Amplitude is variable but is mostly below 50 microvolt in adults. It is best seen with eyes closed and under conditions of physical relaxation and relative mental inactivity. It is blocked or attenuated by attention, especially visual and mental effort. One should here note the difference between the terms alpha rhythm and alpha activity: Alpha activity refers to activity in the range of 8-13 Hz and alpha rhythm is the activity of 8-13 Hz with specific characteristics as defined above.
http://purl.obolibrary.org/obo/HP_0031519	Cauliflower deformity of dermal collagen fibrils	http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology		An anomaly of collagen fibers of the skin that is said to resemble a cauliflower and can be appreciated by electron microscopy.
http://purl.obolibrary.org/obo/HP_0031520	Groin pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the groin region.
http://purl.obolibrary.org/obo/HP_0031521	Vaginal clear cell adenocarcinoma	http://purl.obolibrary.org/obo/HP_0100650	Vaginal neoplasm		A type of adenocarcinoma originating in the vagina and characterized by large cells with moderate to abundant clear cytoplasm.
http://purl.obolibrary.org/obo/HP_0031522	Cervical clear cell adenocarcinoma	http://purl.obolibrary.org/obo/HP_0100650	Vaginal neoplasm		A type of adenocarcinoma originating in the cervix and characterized by large cells with moderate to abundant clear cytoplasm.
http://purl.obolibrary.org/obo/HP_0031523	Salivary gland oncocytoma	http://purl.obolibrary.org/obo/HP_0100684	Salivary gland neoplasm		A benign epithelial neoplasm composed of layers of oncocytes (small round nucleus, micro-granular, eosinophilic cytoplasm with numerous tightly-packed mitochondria)
http://purl.obolibrary.org/obo/HP_0031524	Ampulla of Vater carcinoma	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A carcinoma originating in the ampulla of Vater (also known as the hepatopancreatic duct), which is formed by the union of the pancreatic duct and the common bile duct.
http://purl.obolibrary.org/obo/HP_0031525	Keratoacanthoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		Keratoacanthoma (KA) is a common benign epithelial tumor that originates from the pilosebaceous glands. In most cases, it is characterized by rapid evolution, followed by spontaneous resolution over 4 to 6 months. KA usually presents as a solitary flesh-coloured nodule with a central keratin plug on the sun-exposed skin of elderly individuals.
http://purl.obolibrary.org/obo/HP_0031526	Subretinal fluid	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Fluid accumulating between the neuroretina and retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0031527	Retinal edema	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Accumulation of fluid within the layers of the retina not limited to the macular region.
http://purl.obolibrary.org/obo/HP_0031528	Subretinal deposits	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Deposits accumulating between the outer retina and the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0031531	Sub-RPE deposits	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Deposits accumulating between the retinal pigment epithelium (RPE) and Bruch's membrane.
http://purl.obolibrary.org/obo/HP_0031534	Passive dorsiflexion of the 5th finger more than 90 degrees	http://purl.obolibrary.org/obo/HP_0004207	Abnormal 5th finger morphology		An abnormally increased ability to bend (dorsiflex) one's fifth finger. To assess this feature, the examiner requests to proband to extend the elbows,to bend the wrist back so that it forms a ninety degree angle to the forearm, and to extend the fingers. Then, the proband is requested to bend the fifth finger back as far as is possible without discomfort. If the angle of the fifth finger exceeds 90 degrees, this is considered to be abnormal.
http://purl.obolibrary.org/obo/HP_0031535	Increased theta frequency activity in EEG	http://purl.obolibrary.org/obo/HP_0025373	Interictal EEG abnormality		Increased frequency of theta wave activity in the electroencephalogram. Theta waves have a frequency of 3.5-7.5 Hertz, and are present in very small amounts in healthy waking adult EEGs. Theta activity is normal in small very amounts in the healthy waking adult EEG in a symmetrical distribution.
http://purl.obolibrary.org/obo/HP_0031536	Separate origin of the left anterior descending and left circumflex artery	http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin		Anomalous coronary origin whereby the left anterior descending (LAD) and the left circumflex artery (LCX) arise separately. Normally, these arteries arise from a common stem, the left main coronary artery (LMCA).
http://purl.obolibrary.org/obo/HP_0031537	Anomalous origin of the left circumflex artery from the right coronary artery	http://purl.obolibrary.org/obo/HP_0025505	Anomalous origin of the circumflex artery from the right sinus of Valsalva		An abnormal origin of the left circumflex artery (LCX) from the right coronary artery. Normally, the left anterior descending (LAD) and the LCX arise from a common stem, the left main coronary artery (LMCA).
http://purl.obolibrary.org/obo/HP_0031538	Abnormal dermoepidermal junction morphology	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments.
http://purl.obolibrary.org/obo/HP_0031539	Linear IgA deposits along the epidermal basement membrane zone	http://purl.obolibrary.org/obo/HP_0031538	Abnormal dermoepidermal junction morphology		Presence of IgA antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy.
http://purl.obolibrary.org/obo/HP_0031540	Linear IgG deposits along the epidermal basement membrane zone	http://purl.obolibrary.org/obo/HP_0031538	Abnormal dermoepidermal junction morphology		Presence of IgG antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy.
http://purl.obolibrary.org/obo/HP_0031541	Linear C3 deposits along the epidermal basement membrane zone	http://purl.obolibrary.org/obo/HP_0031538	Abnormal dermoepidermal junction morphology		Presence of complement C3 in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy.
http://purl.obolibrary.org/obo/HP_0031542	Myelin-like whorls in vacuolated fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Muscle fibers contain one or more vacuoles (membrane-bound cavity) associated with collections of membranes arranged in a whorl-like (spiral or circular) manner.
http://purl.obolibrary.org/obo/HP_0031544	Elevated circulating palmitoleylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035021	Elevated circulating C16 acylcarnitine concentration		The concentration palmitoleylcarnitine (hexadecenoylcarnitine or C16:1) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031545	Abnormally low T cell receptor excision circle level	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Reduced level of T cell receptor excision circle (TRECs) as measured by the TREC assay. Late in maturation, 70% of thymocytes that will ultimately express alpha/beta-T cell receptors form a circular DNA TREC from the excised TCRdelta gene that lies within the TCRalpha genetic locus. The circles are stable but do not increase following cell division and, therefore, become diluted as T cells proliferate. A quantitative polymerase chain reaction (PCR) reaction across the joint of the circular DNA provides the TREC copy number, a marker of newly-formed, antigenically-naïve thymic emigrant T cells.
http://purl.obolibrary.org/obo/HP_0031548	Follicular infundibulum tumor	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		A cutaneous adnexal neoplasm with variable clinical presentation. It tends to be located in the head and neck and the presentation is papulonodular, scaly, asymptomatic, measuring up to 1-2cm, simulating a basal cell carcinoma.
http://purl.obolibrary.org/obo/HP_0031549	Lymphocytoma cutis	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		Lymphocytoma cutis, or Spiegler-Fendt sarcoid, is classed as one of the pseudolymphomas, referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Careful clinical evaluation, histopathological and immunohistochemical exams may be needed to make the correct diagnosis.
http://purl.obolibrary.org/obo/HP_0031550	Abnormal flow cytometry test result	http://purl.obolibrary.org/obo/HP_0025354	Abnormal cellular phenotype		Any abnormal result of flow cytometry, a method that suspends cells in a stream of fluid and passes them through an electronic detection apparatus in order to assess cell count or measure biomarkers or surface molecules.
http://purl.obolibrary.org/obo/HP_0031551	Reduced cell surface marker level	http://purl.obolibrary.org/obo/HP_0031550	Abnormal flow cytometry test result		Reduced level of a protein that is normally present on the cell surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031552	Reduced fibroblast surface marker level	http://purl.obolibrary.org/obo/HP_0031551	Reduced cell surface marker level		Reduced level of a protein that is normally present on the fibroblast surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031553	Reduced granulocyte surface marker level	http://purl.obolibrary.org/obo/HP_0031551	Reduced cell surface marker level		Reduced level of a protein that is normally present on the granulocyte surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031554	Reduced granulocyte CD55 level	http://purl.obolibrary.org/obo/HP_0031553	Reduced granulocyte surface marker level		Reduced level of CD55 on the granulocyte surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031555	Reduced granulocyte CD59 level	http://purl.obolibrary.org/obo/HP_0031553	Reduced granulocyte surface marker level		Reduced level of CD59 on the granulocyte surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031556	Reduced granulocyte CD16 level	http://purl.obolibrary.org/obo/HP_0031553	Reduced granulocyte surface marker level		Reduced level of CD16 on the granulocyte surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031557	Reduced fibroblast CD55 level	http://purl.obolibrary.org/obo/HP_0031552	Reduced fibroblast surface marker level		Reduced level of CD55 on the fibroblast surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031558	Reduced fibroblast CD59 level	http://purl.obolibrary.org/obo/HP_0031552	Reduced fibroblast surface marker level		Reduced level of CD59 on the fibroblast surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031559	Reduced fibroblast CD16 level	http://purl.obolibrary.org/obo/HP_0031552	Reduced fibroblast surface marker level		Reduced level of CD16 on the fibroblast surface as assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031560	Coronary cameral fistula	http://purl.obolibrary.org/obo/HP_0011641	Coronary artery fistula		An abnormal communication between coronary artery and a cardiac chamber.
http://purl.obolibrary.org/obo/HP_0031561	Coronary cameral fistula to right ventricle	http://purl.obolibrary.org/obo/HP_0031560	Coronary cameral fistula		An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering the right ventricle.
http://purl.obolibrary.org/obo/HP_0031562	Balanced double aortic arch	http://purl.obolibrary.org/obo/HP_0011590	Double aortic arch		A type of double aortic arch in which the two branches are of equal size. In most cases of double aortic arch, the right aortic arch is larger and located higher than the left aortic arch.
http://purl.obolibrary.org/obo/HP_0031563	Coronary arteriovenous fistula	http://purl.obolibrary.org/obo/HP_0011641	Coronary artery fistula		An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering any segment of the systemic or pulmonary circulation.
http://purl.obolibrary.org/obo/HP_0031564	Bronchial isomerism	http://purl.obolibrary.org/obo/HP_0031853	Isomerism		An anomalous mirror-imaged arrangement of some bronchial structures. Right isomerism is defined as a subset of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures (vice versa for left isomerism).
http://purl.obolibrary.org/obo/HP_0031565	Abdominal situs ambiguus	http://purl.obolibrary.org/obo/HP_0011620	Abnormality of abdominal situs		An abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements.
http://purl.obolibrary.org/obo/HP_0031568	Thickened aortic valve cusp	http://purl.obolibrary.org/obo/HP_0031567	Abnormal aortic valve cusp morphology		An abnormally increased thickness of a leaflet of the aortic valve.
http://purl.obolibrary.org/obo/HP_0031569	Absent aortic valve cusps	http://purl.obolibrary.org/obo/HP_0031567	Abnormal aortic valve cusp morphology		A developmental defect characterized by the lack of aortic valve cusps (leaflets). There may be remnants of the aortic valve in form of a nonobstructive fibrous ridge or rudimentary leaflets or sinuses of Valsalva.
http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the liver		Any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage.
http://purl.obolibrary.org/obo/HP_0410043	Abnormal neural tube morphology	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		Any structural anomaly of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord).
http://purl.obolibrary.org/obo/HP_0550003	Proximal scleroderma	http://purl.obolibrary.org/obo/HP_0100324	Scleroderma		Symmetrical thickening, tightening and induration of the skin of the fingers and the skin proximal to the metacarpophalangeal or metatarsophalangeal joints. These changes can involve the entire limb, face, neck and trunk.
http://purl.obolibrary.org/obo/HP_0550004	Verruca plana	http://purl.obolibrary.org/obo/HP_0200043	Verrucae		Slightly raised wart 2-5 mm in diameter often associated with viral infections, commonly persistent in immunodeficient individuals.
http://purl.obolibrary.org/obo/HP_0550005	Bilateral basilar pulmonary fibrosis	http://purl.obolibrary.org/obo/HP_0002206	Pulmonary fibrosis		It is a bilateral reticular pattern of linear or lineonodular densities that are most pronounced in basilar portions of the lungs on standard chest x-ray. It is the third minor criterion for scleroderma diagnosis.
http://purl.obolibrary.org/obo/GO_0140112	extracellular vesicle biogenesis	http://purl.obolibrary.org/obo/GO_0044085	cellular component biogenesis		The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.
http://purl.obolibrary.org/obo/HP_0031727	Excyclotropia	http://purl.obolibrary.org/obo/HP_0031776	Cyclotropia		A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated outward (laterally) to each other.
http://purl.obolibrary.org/obo/PATO_0045025	normal fragility	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A fragility which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045077	normal variability of size	http://purl.obolibrary.org/obo/PATO_0001956	variability of size		A variability of size which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045060	normal volume	http://purl.obolibrary.org/obo/PATO_0045050	normal size		A volume which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045000	normal rate	http://purl.obolibrary.org/obo/PATO_0045073	normal process quality		A rate which is relatively normal.
http://purl.obolibrary.org/obo/PATO_0045071	normal tonicity	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A tonicity which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045055	normal diameter	http://purl.obolibrary.org/obo/PATO_0045050	normal size		A diameter which is relatively normal or average
http://purl.obolibrary.org/obo/CL_0008028	visual system neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		Any neuron that is capable of part of some visual perception.
http://purl.obolibrary.org/obo/CL_0008031	cortical interneuron	http://purl.obolibrary.org/obo/CL_0010012	cerebral cortex neuron		An interneuron that has its soma located in the cerebral cortex.
http://purl.obolibrary.org/obo/GO_0140352	export from cell	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.
http://purl.obolibrary.org/obo/PR_000050216	receptor-type tyrosine-protein phosphatase C isoform CD45R	http://purl.obolibrary.org/obo/PR_000001006	receptor-type tyrosine-protein phosphatase C		A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A).
http://purl.obolibrary.org/obo/HP_0033379	Bilateral superior vena cava	http://purl.obolibrary.org/obo/HP_0005301	Persistent left superior vena cava		The presence of a left and a right superior vena cava.
http://purl.obolibrary.org/obo/HP_0033429	Neuroinflammation	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain.
http://purl.obolibrary.org/obo/HP_0033454	Tube feeding	http://purl.obolibrary.org/obo/HP_0011968	Feeding difficulties		Feeding problem necessitating food and nutrient delivery via a tube.
http://purl.obolibrary.org/obo/HP_0033460	Elevated circulating apolipoprotein concentration	http://purl.obolibrary.org/obo/HP_0025201	Abnormal circulating apolipoprotein concentration		The concentration of apolipoprotein in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033476	Extractable nuclear antigen positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		The presence of autoantibodies in the serum that react against extractable nuclear components that are referred to as extractable because they can be extracted from cell nuclei with saline solution.
http://purl.obolibrary.org/obo/HP_0033477	Abnormal circulating lipoprotein lipase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		A deviation from the normal concentration of lipoprotein lipase in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033675	Frailty	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised.
http://purl.obolibrary.org/obo/HP_0033676	Posttraumatic stress symptom	http://purl.obolibrary.org/obo/HP_5200230	Maladaptive fear-related cognitions		A behavioral or psychological symptom that typically occurs following exposure to one or more traumatic events is posttraumatic stress disorder (PTSD). Symptoms of PTSD include intrusive recollections, such as re-experiencing the trauma through flashbacks, memories, or nightmares. Additionally, individuals may experience avoidant and numbing symptoms, which can include diminished emotions and avoidance of situations that serve as reminders of the traumatic event. Hyperarousal is another symptom, characterized by increased irritability, exaggerated startle reactions, and difficulties with sleeping or concentrating.
http://purl.obolibrary.org/obo/HP_0033677	Acute respiratory distress syndrome	http://purl.obolibrary.org/obo/HP_5210123	Unusual lower respiratory tract infection		Acute respiratory distress syndrome (ARDS) is defined as an acute disorder that starts within seven days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients have a PaO2/FiO2 ratio of less than 300.
http://purl.obolibrary.org/obo/HP_0033679	Abnormal red nucleus morphology	http://purl.obolibrary.org/obo/HP_0002418	Abnormal midbrain morphology		Any structural anomaly of the red nucleus, a part of the midbrain involved in control of movement.
http://purl.obolibrary.org/obo/HP_0033680	Pilocytic astrocytoma	http://purl.obolibrary.org/obo/HP_0009592	Astrocytoma		The most common form of astrocytoma (WHO Grade I) in childhood. These typically have MAPK signaling pathway abnormalities.
http://purl.obolibrary.org/obo/HP_0033681	Oligodendroglioma	http://purl.obolibrary.org/obo/HP_0009733	Glioma		Oligodendroglioma is a type of diffusely infiltrating glioma and constitutes approximately 5% of primary intracranial tumors. They often involve the cortical gray matter and are most commonly seen in the frontal lobes. OGs are generally low grade WHO grade II neoplasms that are slow-growing tumors and have a favorable treatment response when compared to other gliomas. Grade III anaplastic OG is a more malignant form of the tumor which portends a less favorable prognosis and may occur de novo or as degeneration from the lower grade OG.
http://purl.obolibrary.org/obo/HP_0033682	Pleomorphic xanthoastrocytoma	http://purl.obolibrary.org/obo/HP_0009592	Astrocytoma		Pleomorphic xanthoastrocytomas (PXA) are rare low-grade astrocytomas (WHO Grade II) typically found in the temporal lobe and classically presenting with epilepsy. PXA is an astrocytic neoplasm that most often presents in children or young adults but can also occur in adults. The diagnosis of anaplastic PXA is made based upon tumor histopathologic characteristics and requires increased proliferative activity (mitotic index at least 5 mitoses/10 HPF), which is associated with worse overall survival. In general, anaplastic PXAs acquire features of a more aggressive astrocytic neoplasm that can include increased proliferation, necrosis, microvascular proliferation, loss of pericellular reticulin, and increased infiltrative growth.
http://purl.obolibrary.org/obo/HP_0033683	Jaw hyperreflexia	http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia		Increased intensity of muscle tendon reflexes in jaw.
http://purl.obolibrary.org/obo/HP_0033685	Fiber type grouping	http://purl.obolibrary.org/obo/HP_0033684	Abnormal muscle fiber-type distribution		An abnormal distribution of muscle fiber types in muscle tissue. Human skeletal muscle contains at least two fiber types recognizable by histochemical techniques. In transverse sections of normal skeletal muscle, type 1 and type 2 fibers are distributed in a random fashion. Grouping of fibers of the same type can be seen in certain peripheral neuropathies, thought to be due to reinnervation of denervated muscle fibers by sprouting axons. With grouping, motor units enlarge. The fibers of a motor unit, which are normally scattered, come to lie adjacent to one another. Histochemical examination shows groups of muscle fibers of the same histochemical type.
http://purl.obolibrary.org/obo/HP_0033686	Mitochondrial hypertrophy	http://purl.obolibrary.org/obo/HP_0012087	Abnormal mitochondrial shape		Enlargement of mitochondria. Mitochondrial hypertrophy is not discernible by light microscopy. By electron microscopy (EM), hypertrophic mitochondria have normal cristae and normal matrix density. In contrast, swollen mitochondria display swollen cristae and irregular matrix densities in EM.
http://purl.obolibrary.org/obo/HP_0033688	Long term memory impairment	http://purl.obolibrary.org/obo/HP_0002354	Memory impairment		A deficit in the ability to retrieve information from long-term memory, which can be defined as a seemingly unlimited capacity to store memories can last years and relate to the performance of actions or skills (i.e., procedural memories, knowing how) and memories of facts, rules, concepts, and events (i.e., declarative memories, knowing that).
http://purl.obolibrary.org/obo/HP_0033689	Anterograde memory impairment	http://purl.obolibrary.org/obo/HP_0033688	Long term memory impairment		The impaired ability to establish new long-term memories.
http://purl.obolibrary.org/obo/HP_0033690	Retrograde memory impairment	http://purl.obolibrary.org/obo/HP_0033688	Long term memory impairment		Inability to retrieve information from the long-term memory that was acquired before the onset of amnesia.
http://purl.obolibrary.org/obo/HP_0033691	Procedural memory loss	http://purl.obolibrary.org/obo/HP_0033690	Retrograde memory impairment		A reduction in the ability to retrieve information about how to perform activities, such as how to ride a bike or drive a car, how to perform activities of daily living, or how to play a musical instrument.
http://purl.obolibrary.org/obo/HP_0033692	Declarative memory loss	http://purl.obolibrary.org/obo/HP_0033690	Retrograde memory impairment		Impaired ability to remember facts and events.
http://purl.obolibrary.org/obo/HP_0033694	Tactile hallucination	http://purl.obolibrary.org/obo/HP_5200214	Somatic hallucination		Perception of touch without a tactile stimulus.
http://purl.obolibrary.org/obo/HP_0033695	Occupational disability	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		This is a general term that denotes a reduced ability to perform the work that one performed prior to an illness, and may be related to pain, cognitive dysfunction, fatigue or other physical disabilities.
http://purl.obolibrary.org/obo/HP_0033696	Pseudo-chilblain	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Acral areas of erythema with vesicles or pustules. The lesions resemble chilblains and have purpuric areas, affecting hands and feet.
http://purl.obolibrary.org/obo/HP_0033697	Vesicular eruption	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		A type of acute-onset skin rash characterized by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point. The fluid contained in a vesicle may be clear, serous, or hemorrhagic.
http://purl.obolibrary.org/obo/HP_0033698	Monomorphic vesicular eruption	http://purl.obolibrary.org/obo/HP_0033697	Vesicular eruption		A type of vesicular eruption in which the vesicles are at same stages.
http://purl.obolibrary.org/obo/HP_0033699	Polymorphic vesicular eruption	http://purl.obolibrary.org/obo/HP_0033697	Vesicular eruption		A type of vesicular eruption in which the vesicles are at different stages.
http://purl.obolibrary.org/obo/HP_0033700	Papulovesicular eruption	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		An acute onset rash characterized by by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevations with a diameter less than 10mm at the widest point, and by multiple papules, which are circumscribed, solid epidermal elevations with no visible fluid with a diameter less than 10mm at the widest point.
http://purl.obolibrary.org/obo/HP_0033701	Cortical sclerosis of the iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		Increased density related to increased bone mass in the outermost layer (edge) of the iliac wing.
http://purl.obolibrary.org/obo/HP_0033702	Subpleural curvilinear line	http://purl.obolibrary.org/obo/HP_0031630	Abnormal subpleural morphology		This finding is a thin curvilinear opacity, 1-3 mm in thickness, lying less than 1 cm from and parallel to the pleural surface. It corresponds to atelectasis of normal lung if seen in the dependent posteroinferior portion of lung of a patient in the supine position and is subsequently shown to disappear on CT sections acquired with the patient prone. It may also be encountered in patients with pulmonary edema or fibrosis (other signs are usually present).
http://purl.obolibrary.org/obo/HP_0033703	Dysembryoplastic neuroepithelial tumor	http://purl.obolibrary.org/obo/HP_0025170	Neuronal/glioneuronal neoplasm of the central nervous system		Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Lesions vary in size from 10 to 25 mm, although occasionally larger tumors of up to 70 mm have been reported. Grossly, tumors appear as well-defined, solitary nodular masses or poorly demarcated lesions. On the cut section, most tumors are cortically located and may extend into the underlying subcortical white matter in larger tumors. Multi-nodular appearance or cystic changes are commonly found
http://purl.obolibrary.org/obo/HP_0033704	Elevated urinary homogentisic acid	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		An increased amount of homogentisic acid in the urine.
http://purl.obolibrary.org/obo/HP_0033705	Tearfulness	http://purl.obolibrary.org/obo/HP_5200261	Abnormal demeanor		A feeling of sadness characterized by episodes of crying that can occur suddenly and are not easily controlled in social situations.
http://purl.obolibrary.org/obo/HP_0033706	Progressive massive fibrosis	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		This condition is caused by slow-growing conglomeration of dust particles and collagen deposition in individuals (mostly coal workers) heavily exposed to inorganic dust. Progressive massive fibrosis manifests as masslike lesions, usually bilateral and in the upper lobes. Background nodular opacities reflect accompanying pneumoconiosis, with or without emphysematous destruction adjacent to the massive fibrosis. Lesions similar to progressive massive fibrosis sometimes occur in other conditions, such as sarcoidosis and talcosis.
http://purl.obolibrary.org/obo/HP_0033707	Perioral hyperkeratosis	http://purl.obolibrary.org/obo/HP_0034521	Periorificial hyperkeratosis		Increased thickness of the stratum corneum (the outer layer of the skin) in the skin surrounding the mouth.
http://purl.obolibrary.org/obo/HP_0033709	Increased sputum production	http://purl.obolibrary.org/obo/HP_0032016	Abnormal sputum		An increase in the amount of airway mucus. This feature may be characterized by frequent or excessive throat clearing (exhalation through tightly constricted laryngopharyngeal tissues accompanied by vibration of the palatoglossal arch and the vocal folds serving to clear mucus from the airway).
http://purl.obolibrary.org/obo/HP_0033710	Rest dyspnea	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		A perception of shortness of breath that occurs independently of exertion.
http://purl.obolibrary.org/obo/HP_0033712	Repeated implantation failure	http://purl.obolibrary.org/obo/HP_0033335	Abnormal preimplantation embryonic development		Repeated implantation failure refers to a situation in which embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles.
http://purl.obolibrary.org/obo/HP_0033713	Anti-signal recognition particle antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against anti-signal recognition particle.
http://purl.obolibrary.org/obo/HP_0033714	Multiple meningiomas	http://purl.obolibrary.org/obo/HP_0002858	Meningioma		The occurrence of multiple distinct meningiomas in the same individual.
http://purl.obolibrary.org/obo/HP_0033715	Hippocampal sclerosis	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		Hippocampal sclerosis is a neuropathologic finding characterized by neuronal loss and gliosis in the CA-1 and subiculum of the hippocampus.
http://purl.obolibrary.org/obo/HP_0033722	Autonomic epileptic aura	http://purl.obolibrary.org/obo/HP_0033348	Epileptic aura		An autonomic epileptic aura is a purely subjective manifestation of an epileptic seizure pertaining to autonomic nervous system function. Autonomic auras include cardiorespiratory (e.g., palpitations and shortness of breath), gastrointestinal, genitourinary (genital sensations, urinary urge), and cutaneous (feeling of warmth or cold) sensations. Abdominal auras constitute the most common type of autonomic aura. These include sensations of nausea, pain, or indescribable discomfort in the abdominal or periumbilical area that can be static, rise to the chest and throat, or descend into the lower abdominal region.
http://purl.obolibrary.org/obo/HP_0033723	Abnormal cerebral venous sinus morphology	http://purl.obolibrary.org/obo/HP_0012480	Abnormal cerebral vein morphology		Abnormal structure of the venous sinuses that drain blood from the cerebral veins and cerebrospinal fluid (CSF) from the arachnoid granulations to the internal jugular veins.
http://purl.obolibrary.org/obo/HP_0033724	Cerebral venous sinus thrombosis	http://purl.obolibrary.org/obo/HP_0004936	Venous thrombosis		An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses.
http://purl.obolibrary.org/obo/HP_0033726	Lupus nephritis	http://purl.obolibrary.org/obo/HP_0000099	Glomerulonephritis		Lupus nephritis is a type of glomerulonephritis that constitutes one of the most severe organ manifestations of systemic lupus erythematosus. Lupus nephritis is subclassified in six distinct classes, that represent different manifestations and severities of renal involvement and guide the therapeutic management.
http://purl.obolibrary.org/obo/HP_0033727	Diffuse lupus nephritis	http://purl.obolibrary.org/obo/HP_0033726	Lupus nephritis		A subclass of lupus nephritis with active or inactive diffuse, segmental or global endocapillary or extracapillary glomerulonephritis involving at least 50% of all glomeruli, typically with diffuse subendothelial immune deposits, with or without mesangial alterations.
http://purl.obolibrary.org/obo/HP_0033728	Mesangial proliferative lupus nephritis	http://purl.obolibrary.org/obo/HP_0033726	Lupus nephritis		A subclass of lupus nephritis with purely mesangial hypercellularity of any degree or mesangial matrix expansion by lightmicroscopy, with mesangial immune deposits. A few isolated subepithelial or subendothelial deposits may be visible by immunoflourescence or electron microscopy, but not by light microscopy.
http://purl.obolibrary.org/obo/HP_0033729	Minimal mesangial lupus nephritis	http://purl.obolibrary.org/obo/HP_0033726	Lupus nephritis		A subclass of lupus nephritis with normal glomeruli by light microscopy, but mesangial immune deposits by immunofluorescence.
http://purl.obolibrary.org/obo/HP_0033730	Membranous lupus nephritis	http://purl.obolibrary.org/obo/HP_0033726	Lupus nephritis		A lupus nephritis subclass with global or segmental subepithelial immune deposits or their morphological sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. May occur in combination with class III or IV, in which case both classes are diagnosed. May show advanced sclerosis
http://purl.obolibrary.org/obo/HP_0033731	Focal lupus nephritis	http://purl.obolibrary.org/obo/HP_0033726	Lupus nephritis		A subclass of lupus nephritis with active or inactive focal, segmental or global endocapillary or extracapillary glomerulonephritis involving less than 50% of all glomeruli, typically with focal subendothelial immune deposits, with or without mesangial alterations
http://purl.obolibrary.org/obo/HP_0033732	Advanced sclerotic lupus nephritis	http://purl.obolibrary.org/obo/HP_0033726	Lupus nephritis		A subclass of lupus nephritis with at least 90% of glomeruli globally sclerosed without residual activity.
http://purl.obolibrary.org/obo/HP_0033733	Low-grade vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0000076	Vesicoureteral reflux		Vesicoureteral reflux without dilation of the renal calyces (Grade I-II).
http://purl.obolibrary.org/obo/HP_0033734	High-grade vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0000076	Vesicoureteral reflux		Vesicoureteral reflux with dilation of the renal calyces (Grade III - V).
http://purl.obolibrary.org/obo/HP_0033735	Grade I vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0033733	Low-grade vesicoureteral reflux		Vesicoureteral reflux into the ureter only.
http://purl.obolibrary.org/obo/HP_0033736	Grade II vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0033733	Low-grade vesicoureteral reflux		Vesicoureteral reflux into a non-dilated pyelocalyceal system.
http://purl.obolibrary.org/obo/HP_0033737	Grade III vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0033734	High-grade vesicoureteral reflux		Vesicoureteral reflux with dilatation of the collecting system.
http://purl.obolibrary.org/obo/HP_0033738	Primary vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0000076	Vesicoureteral reflux		Vesicoureteral reflux due to abnormalities in ureterovesical junction, e.g. ectopic insertion of the ureter or short intravesical tunnel at the ureterovesical junction.
http://purl.obolibrary.org/obo/HP_0033739	Secondary vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0000076	Vesicoureteral reflux		Vesicoureteral reflux induced by increased bladder pressures in patients with voiding dysfunction e.g. in case of congenital posterior urethral valves or neurogenic bladder dysfunction.
http://purl.obolibrary.org/obo/HP_0033740	Grade V vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0033734	High-grade vesicoureteral reflux		Vesicoureteral reflux with massive dilation of the collecting system and severe tortuosity of the ureter.
http://purl.obolibrary.org/obo/HP_0033741	Grade IV vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0033734	High-grade vesicoureteral reflux		Vesicoureteral reflux with more-extensive dilation with blunting of the calyces and tortuosity of the ureter.
http://purl.obolibrary.org/obo/HP_0033742	Intrarenal reflux	http://purl.obolibrary.org/obo/HP_0033734	High-grade vesicoureteral reflux		Severe vesicoureteral reflux reaching the kidney parenchyma.
http://purl.obolibrary.org/obo/HP_0033743	Macular agenesis	http://purl.obolibrary.org/obo/HP_0008059	Aplasia/Hypoplasia of the macula		A congenital defect characterized by lack of development of the macula.
http://purl.obolibrary.org/obo/HP_0033744	Global cerebellar dysplasia	http://purl.obolibrary.org/obo/HP_0007033	Cerebellar dysplasia		A type of cerebellar dysplasia that affects the entire cerebellum.
http://purl.obolibrary.org/obo/HP_0033745	Dysplasia of the superior cerebellar vermis	http://purl.obolibrary.org/obo/HP_0007033	Cerebellar dysplasia		A type of cerebellar dysplasia that affects the upper part of the cerebellar vermis.
http://purl.obolibrary.org/obo/HP_0033746	Intrascapular pain	http://purl.obolibrary.org/obo/HP_0003418	Back pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the area between the shoulder blades.
http://purl.obolibrary.org/obo/HP_0033748	Hypoesthesia	http://purl.obolibrary.org/obo/HP_0033747	Abnormal exteroceptive sensation		Decreased ability to perceive touch.
http://purl.obolibrary.org/obo/HP_0033749	Abnormal functional residual capacity	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		A deviation from normal values for the functional residual capacity, which is defined as the volume remaining in the lungs after a normal, passive exhalation.
http://purl.obolibrary.org/obo/HP_0033750	Reduced functional residual capacity	http://purl.obolibrary.org/obo/HP_0033749	Abnormal functional residual capacity		An abnormal reduction in the volume remaining in the lungs after a normal, passive exhalation.
http://purl.obolibrary.org/obo/HP_0033751	Elevated functional residual capacity	http://purl.obolibrary.org/obo/HP_0033749	Abnormal functional residual capacity		An abnormal increase in the volume remaining in the lungs after a normal, passive exhalation.
http://purl.obolibrary.org/obo/HP_0033752	Abnormal residual volume	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		Any deviation from normal values of the residual volume, which is defined as the volume of air left in the lungs at the end of maximal expiration (ie. the volume of air which you cannot voluntarily exhale from your lungs).
http://purl.obolibrary.org/obo/HP_0033753	Reduced residual volume	http://purl.obolibrary.org/obo/HP_0033752	Abnormal residual volume		Abnormal decrease in the amount of air remaining in a person's lungs after full exhalation.
http://purl.obolibrary.org/obo/HP_0033754	Abnormal left ventricular end-diastolic volume	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		Any deviation from the normal range of end-diastolic volume of the left ventricle, which is the volume of blood in the left ventricle at the end of diastole (just before systole).
http://purl.obolibrary.org/obo/HP_0033755	Increased left ventricular end-diastolic volume	http://purl.obolibrary.org/obo/HP_0033754	Abnormal left ventricular end-diastolic volume		Abnormally high volume of blood in the left ventricle at the end of diastole (just before systole).
http://purl.obolibrary.org/obo/HP_0033756	Decreased left ventricular end-diastolic volume	http://purl.obolibrary.org/obo/HP_0033754	Abnormal left ventricular end-diastolic volume		Abnormally low volume of blood in the left ventricle at the end of diastole (just before systole).
http://purl.obolibrary.org/obo/HP_0033757	Pancreatic steatosis	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Fat infiltration in the pancreas.
http://purl.obolibrary.org/obo/HP_0033758	Labial abscess	http://purl.obolibrary.org/obo/HP_0033587	Vulvar abscess		A circumscribed area of pus or necrotic debris in the labia.
http://purl.obolibrary.org/obo/HP_0033759	Impaired renal tubular reabsorption of magnesium	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Decreased renal tubular reabsorption of magnesium.
http://purl.obolibrary.org/obo/HP_0033760	Decreased maximal oxygen uptake	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		Maximum oxygen uptake (VO2max) is defined as the highest rate of oxygen uptake and utilization by the body during intense, maximal exercise, whereby further increases in work rate do not bring on additional rises in VO2 (i.e. plateau). VO2Max is typically measured with a treadmill and ergometer and the participant exercises with increasing levels of intensity. VO2Max is the point at which oxygen uptake no longer increases despite an increase in workload.
http://purl.obolibrary.org/obo/HP_0033761	Xanthogranulomatous pyelonephritis	http://purl.obolibrary.org/obo/HP_0012330	Pyelonephritis		Xanthogranulomatous pyelonephritis is a granulomatous inflammatory infiltrate composed of neutrophils, lymphocytes, plasma cells, xanthomatous histiocytes, and multinucleated giant cells.
http://purl.obolibrary.org/obo/HP_0033762	Middle cerebral artery stroke	http://purl.obolibrary.org/obo/HP_0001297	Stroke		Acute onset neurological deficits such as weakness, dizziness, numbness, issues with speech, or visual changes related to sudden impairment of blood flow to a part of the brain due to occlusion or rupture of the middle cerebral artery to the brain.
http://purl.obolibrary.org/obo/HP_0033763	Death in adulthood	http://purl.obolibrary.org/obo/HP_0011420	Age of death		Cessation of life at the age of 16 years or later.
http://purl.obolibrary.org/obo/HP_0033764	Death in middle age	http://purl.obolibrary.org/obo/HP_0033763	Death in adulthood		Death between the age of 40 and 60 years.
http://purl.obolibrary.org/obo/HP_0033765	Death in late adulthood	http://purl.obolibrary.org/obo/HP_0033763	Death in adulthood		Death at an age of at least 60 years.
http://purl.obolibrary.org/obo/HP_0033766	Polymelia	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		Polymelia is a congenital anomaly, which is defined as the presence of accessory limbs attached to various body regions and could be classified as cephalomelia (extra-limb attached to the head), notomelia (extra-limb attached to the back bone), thoracomelia (extra-limb attached to the thorax), and pyromelia (extra-limb attached to the pelvis).
http://purl.obolibrary.org/obo/HP_0033767	Abnormal single motor unit action potential	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		Abnormally high or low single motor unit action potential reading (-Pk Amps).
http://purl.obolibrary.org/obo/HP_0033768	Penile thrush	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Overgrowth of candida albicans in the penis.
http://purl.obolibrary.org/obo/HP_0033769	Fundic gland polyposis	http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach		Multiple polyps in the acid-secreting mucosa of the gastric body and fundus. Fundic gland polyps (FGP) are usually 1 to 5 mm in size, though larger polyps have been found. FGPs are typically sessile, shiny, translucent, pale to pinkish in color (resembling the surrounding mucosa), and often exhibit tiny surface blood vessels. These polyps have characteristically been observed to chunk off or detach entirely at the base when removed with cold forceps, in contrast to other types of gastric polyps.
http://purl.obolibrary.org/obo/HP_0033770	Gastric adenocarcinoma	http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach		An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia.
http://purl.obolibrary.org/obo/HP_0033771	Pleuritic chest pain	http://purl.obolibrary.org/obo/HP_0100749	Chest pain		Pleuritic chest pain is characterized by sudden and intense sharp, stabbing, or burning pain in the chest when inhaling and exhaling.
http://purl.obolibrary.org/obo/HP_0033772	Abnormal RV/TLC ratio	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		Any deviation from the normal ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography.
http://purl.obolibrary.org/obo/HP_0033773	Decreased RV/TLC ratio	http://purl.obolibrary.org/obo/HP_0033772	Abnormal RV/TLC ratio		An abnormally low ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining after maximal expiration and TLC is the total amount of air in the lungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography.
http://purl.obolibrary.org/obo/HP_0033774	Impaired renal tubular reabsorption of uric acid	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Decreased renal tubular reabsorption of uric acid.
http://purl.obolibrary.org/obo/HP_0033775	Pulmonary imaging sign	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		An abnormal pulmonary imaging finding defined by eponym or reference to signs, symbols, or naturalistic images.
http://purl.obolibrary.org/obo/HP_0033776	Enamel pearls	http://purl.obolibrary.org/obo/HP_0000682	Abnormal dental enamel morphology		Small nodules of enamel on the root of a tooth.
http://purl.obolibrary.org/obo/HP_0033778	Leung cusp	http://purl.obolibrary.org/obo/HP_0033777	Supernumerary cusp		An additional cusp located in the middle of the occlusal surface.
http://purl.obolibrary.org/obo/HP_0033779	Barrel-shaped tooth	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		A tooth crown with convex mesial and distal surfaces.
http://purl.obolibrary.org/obo/HP_0033780	Bulbous tooth	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		A tooth crown with a marked cervical area constriction.
http://purl.obolibrary.org/obo/HP_0033781	Tapered tooth	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		A tooth with a crown that narrows from proximal toward the incisal edge. Tapering of teeth typically involves incisors.
http://purl.obolibrary.org/obo/HP_0033782	Semilunar tooth	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		An incisor with a half-moon shape incisal edge.
http://purl.obolibrary.org/obo/HP_0033783	Molar incisor malformation	http://purl.obolibrary.org/obo/HP_0011070	Abnormal molar morphology		Molar incisor malfomation (MIM) is composed of normal crown with marked cervical constriction, thin, narrow short roots which is a combination of signs that occurs in deciduous and permanent molars.
http://purl.obolibrary.org/obo/HP_0033784	Dentin dysplasia	http://purl.obolibrary.org/obo/HP_0010299	Abnormal dentin morphology		This is a bundled term as dentin dysplasia is composed of short roots with pointed ends and taurodontism and intrapulpal calcifications.
http://purl.obolibrary.org/obo/HP_0033785	Enamel agenesis	http://purl.obolibrary.org/obo/HP_0000682	Abnormal dental enamel morphology		Complete or almost complete absence of enamel.
http://purl.obolibrary.org/obo/HP_0033786	Hypomature enamel	http://purl.obolibrary.org/obo/HP_0000682	Abnormal dental enamel morphology		Enamel with a white or brown discoloration without hypoplasia.
http://purl.obolibrary.org/obo/HP_0033787	Cementum hypoplasia	http://purl.obolibrary.org/obo/HP_0100717	Abnormal cementum morphology		The decrease or absence of cementum. The cementum anchors the periodontal ligament attachment fiber between the tooth root and the alveolar bone. Its absence leads to early loss of teeth.
http://purl.obolibrary.org/obo/HP_0033788	Cementum overgrowth	http://purl.obolibrary.org/obo/HP_0100717	Abnormal cementum morphology		Excess of cementum on the tooth root surface.
http://purl.obolibrary.org/obo/HP_0033789	Triggered by cheese ingestion	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by eating cheese.
http://purl.obolibrary.org/obo/HP_0033790	Thistle tube shaped pulp	http://purl.obolibrary.org/obo/HP_0006479	Abnormal dental pulp morphology		A thistle tube shape of the pulp chamber, meaning an enlarged coronal pulp chamber with narrow pulp canals giving a radiographic appearance of the shape of a thistle tube or a flame. It may occur isolated or associated with other dental anomalies and rare diseases such as dentinogenesis imperfecta, which should be assessed and coded separately. The diagnosis thistle tube shape pulp requires clinical and radiographic examinations.
http://purl.obolibrary.org/obo/HP_0033791	Tooth ankylosis	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		Fusion of a tooth with alveolar bone.
http://purl.obolibrary.org/obo/HP_0033792	Cross bite	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Lingual occlusion of buccal cusps and/or incisal edge of maxillary teeth to the buccal cusps and/or incisal edge of mandibular teeth.
http://purl.obolibrary.org/obo/HP_0033794	Acral overgrowth	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		Excessive growth of hands and feet (predominantly due to soft tissue swelling). Typical manifestations include shoe size increase, foot enlargement, glove tightness, and hand enlargement.
http://purl.obolibrary.org/obo/HP_0033797	Leukocyte migration defect	http://purl.obolibrary.org/obo/HP_0033796	Abnormal leukocyte physiology		Any abnormality of leukocyte motility in response to chemokines, which is required for the inflammatory response to infections, and for organ development, tissues homeostasis, and vascularization.
http://purl.obolibrary.org/obo/HP_0033801	Blistering by histological location	http://purl.obolibrary.org/obo/HP_0008066	Abnormal blistering of the skin		Blistering (presence of multiple fluid filled blisters) categorized according to the layer of the skin in which the blister originates. The skin is divided into three layers. The epidermis (outermost layer, which mainly consists of keratinocytes), the dermis, and a subcutaneous layer. The epidermis is divided into five layers: the basal lamina (innermost layer), the basal cell layer, the stratum spinosum, the stratum granulosum, and the stratum corneum (outermost layer). Cleavage in epidermolysis bullosa (EB) simplex occurs within the basal keratinocytes; in junctional EB, within the lamina lucida; and in dystrophic EB occurs in the sublamina densa, in the upper portion of the dermis (papillary dermis). In Kindler's EB, cleavage can occur in the basal keratinocytes, in the lamina lucida, or below the lamina densa.
http://purl.obolibrary.org/obo/HP_0033802	Intra-epidermal blistering	http://purl.obolibrary.org/obo/HP_0033801	Blistering by histological location		A type of blistering in which the lesions are located within the epidermis with loss of cell-cell adhesion of keratinocytes. In simplex EB, cleavage occurs in the basal layer, which is the innermost layer of the epidermis and consists of a single layer of basal germinative cells (mostly epidermal Keratinocytes) that proliferate and thereby produce new cells for other epidermal layers. As the cells move towards the upper layers of the epidermis they mature and eventually form cornified cells. The suprabasal cell layer lies directly above the basal layer and is composed of five to ten layers of cells.
http://purl.obolibrary.org/obo/HP_0033803	Sub-lamina densa cleavage	http://purl.obolibrary.org/obo/HP_0033804	Subepidermal blistering		A type of blistering in which the cleavage plane of blisters is located below the lamina densa.
http://purl.obolibrary.org/obo/HP_0033805	Non-necrotizing granuloma	http://purl.obolibrary.org/obo/HP_0032252	Granuloma		A granuloma which is not associated with necrotic changes.
http://purl.obolibrary.org/obo/HP_0033806	Abnormal epidermis stratum granulosum morphology	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		An abnormal structure of the stratum granulosum, which is is a thin layer of cells in the epidermis lying above the stratum spinosum and below the stratum corneum.
http://purl.obolibrary.org/obo/HP_0033807	Absent keratohyalin granules	http://purl.obolibrary.org/obo/HP_0033806	Abnormal epidermis stratum granulosum morphology		Lack of keratohyalin granules, which are normally present in the stratum granulosum of the epidermal layer of the skin.
http://purl.obolibrary.org/obo/HP_0033808	Spermatocele	http://purl.obolibrary.org/obo/HP_0009714	Abnormal epididymis morphology		A cystic structure arising from the epididymis, rete testis or efferent ductuli. These structures are filled with spermatozoa containing fluid that may be milky. These cysts are usually outside the tunica vaginalis and, as with hydrocele, transluminate easily.
http://purl.obolibrary.org/obo/HP_0033809	Increased circulating 17 hydroxypregnenolone concentration	http://purl.obolibrary.org/obo/HP_0031187	Abnormal circulating pregnenolone concentration		Increased concentration of 17alpha-hydroxypregnenolone in the blood circulation. 17alpha-hydroxypregnenolone is a 21-carbon steroid that is converted from pregnenolone by steroid 17-alpha-hydroxylase, as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.
http://purl.obolibrary.org/obo/HP_0033810	Decreased circulating dihydrotestosterone concentration	http://purl.obolibrary.org/obo/HP_0030349	Decreased circulating androgen concentration		A reduced concentration of dihydrotestosterone in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033812	Decreased circulating androstenedione concentration	http://purl.obolibrary.org/obo/HP_0033811	Abnormal circulating androstenedione concentration		Reduced concentration of androstenedione in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033813	Perilobular	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Situated or occurring around a lobe of an organ.
http://purl.obolibrary.org/obo/HP_0033814	Paraseptal	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa.
http://purl.obolibrary.org/obo/HP_0033815	Bronchocentric	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Centered in bronchi or bronchioles.
http://purl.obolibrary.org/obo/HP_0033816	Centrilobular	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Located in the center of the secondary pulmonary lobules, which are the functional units of the lungs.
http://purl.obolibrary.org/obo/HP_0033817	Miliary	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Characterized by numerous small lesions said to resemble millet seed.
http://purl.obolibrary.org/obo/HP_0033818	Reticular	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance resembles a net or network-like structure.
http://purl.obolibrary.org/obo/HP_0033819	Perilymphatic	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance are located at or near lymphatic structures (node or vessel).
http://purl.obolibrary.org/obo/HP_0033820	Apical	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance are located at the apex of an organ. For instance, apical refers to the superior portion of the lung.
http://purl.obolibrary.org/obo/HP_0033821	Pulmonary mass	http://purl.obolibrary.org/obo/HP_0033822	Mass on thoracic imaging		A mass in the lung seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).
http://purl.obolibrary.org/obo/HP_0033822	Mass on thoracic imaging	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		A mass is any pulmonary, pleural, or mediastinal lesion seen on chest radiographs as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics). Mass usually implies a solid or partly solid opacity. CT allows more exact evaluation of size, location, attenuation, and other features.
http://purl.obolibrary.org/obo/HP_0033823	Mediastinal mass	http://purl.obolibrary.org/obo/HP_0033822	Mass on thoracic imaging		A mass in the mediastinum seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).
http://purl.obolibrary.org/obo/HP_0033824	Pleural mass	http://purl.obolibrary.org/obo/HP_0033822	Mass on thoracic imaging		A mass in the pleura seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).
http://purl.obolibrary.org/obo/HP_0033825	Superior mediastinal mass	http://purl.obolibrary.org/obo/HP_0033823	Mediastinal mass		A type of mediastinal mass that is located above the thoracic plane (a horizontal line that runs from the manubriosternal joint (sternal angle or angle of Louis) to the inferior endplate of T4).
http://purl.obolibrary.org/obo/HP_0033826	Inferior mediastinal mass	http://purl.obolibrary.org/obo/HP_0033823	Mediastinal mass		A type of mediastinal mass that is located below the thoracic plane (a horizontal line that runs from the manubriosternal joint (sternal angle or angle of Louis) to the inferior endplate of T4).
http://purl.obolibrary.org/obo/HP_0033827	Anterior mediastinal mass	http://purl.obolibrary.org/obo/HP_0033826	Inferior mediastinal mass		A type of inferior mediastinal mass that is located in front of the pericardium.
http://purl.obolibrary.org/obo/HP_0033828	Middle mediastinal mass	http://purl.obolibrary.org/obo/HP_0033826	Inferior mediastinal mass		A type of inferior mediastinal mass that is located withinthe pericardium.
http://purl.obolibrary.org/obo/HP_0033829	Posterior mediastinal mass	http://purl.obolibrary.org/obo/HP_0033826	Inferior mediastinal mass		A type of inferior mediastinal mass that is located behind the pericardium.
http://purl.obolibrary.org/obo/HP_0033830	Hyperdense pulmonary mass	http://purl.obolibrary.org/obo/HP_0033821	Pulmonary mass		A type of pulmonary mass with high attenuation.
http://purl.obolibrary.org/obo/HP_0033831	Cavitating pulmonary mass	http://purl.obolibrary.org/obo/HP_0033655	Pulmonary cavity		Thick-walled abnormal gas-filled interstitial mass within a lung with a diameter greater than 30 mm.
http://purl.obolibrary.org/obo/HP_0033832	Livedo	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		A reddish-blue mottled condition of skin caused by inflammation of the cutaneous blood vessels.
http://purl.obolibrary.org/obo/HP_0033833	Elevated circulating sCD25 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of sCD25 (= soluble CD25, = soluble interleukin-2 receptor alpha-chain, = soluble IL-2 receptor alpha) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033834	Malaise	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A feeling of general discomfort, weakness, or lack of health.
http://purl.obolibrary.org/obo/HP_0033836	Abnormal intrarenal artery morphology	http://purl.obolibrary.org/obo/HP_0033835	Abnormal renal vascular morphology		An anomalous structure of an artery located in the kidney.
http://purl.obolibrary.org/obo/HP_0033837	Abnormal arcuate artery morphology	http://purl.obolibrary.org/obo/HP_0033836	Abnormal intrarenal artery morphology		Anomalous structure of the arc-shaped arteries located at the border of the renal cortex and renal medulla.
http://purl.obolibrary.org/obo/HP_0033838	Dysphoria	http://purl.obolibrary.org/obo/HP_0031467	Dysregulated negative emotional state		A pervasive state of negatively valenced emotional unease and dissatisfaction along with an inner discomfort that is disproportionate to external circumstances and may include heightened emotional reactivity. It is associated with a mixture of overlapping negative emotions that are difficult to disentangle.
http://purl.obolibrary.org/obo/HP_0033839	Testicular pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to one or both testes.
http://purl.obolibrary.org/obo/HP_0033840	Postmenopausal bleeding	http://purl.obolibrary.org/obo/HP_0030012	Abnormal female reproductive system physiology		Uterine bleeding that occurs after at least one year of amenorrhea in a woman who is not receiving hormone therapy.
http://purl.obolibrary.org/obo/HP_0033841	Ocular pruritus	http://purl.obolibrary.org/obo/HP_0000989	Pruritus		Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching in the region of the eye.
http://purl.obolibrary.org/obo/HP_0033842	Early satiety	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		The condition of being unable to eat a full meal because of a feeling of fullness (satiety), or or feeling very full after eating only a small amount of food.
http://purl.obolibrary.org/obo/HP_0033843	Postprandial fullness	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Feeling excessively full after meals.
http://purl.obolibrary.org/obo/HP_0033844	Racing thoughts	http://purl.obolibrary.org/obo/HP_0025781	Abnormally rapid thought process		An inner sense (from the self) that thoughts are moving abnormally fast and in a manner that the individual typically feels that the rate is beyond their control, i.e. they feel unable to slow the rate of thoughts. Racing thoughts by themselves have a linear progression, following a line of thinking or logic, which distinguishes racing thoughts from flight of ideas. Racing thoughts may however, co-occur with or be independent from flight of ideas, they may be associated with pressured speech or be an internal perception of the rate of thinking. The core element being the rate of the thoughts themselves.
http://purl.obolibrary.org/obo/HP_0033845	Sense of impending doom	http://purl.obolibrary.org/obo/HP_5200401	Abnormal judgment		A feeling that something life-threatening or tragic is about to occur.
http://purl.obolibrary.org/obo/HP_0033846	Spinal hypomyelination	http://purl.obolibrary.org/obo/HP_0003429	CNS hypomyelination		Reduced amount of myelin in the spinal cord resulting from defective myelinogenesis.
http://purl.obolibrary.org/obo/HP_0033847	Phantageusia	http://purl.obolibrary.org/obo/HP_0000223	Abnormality of taste sensation		A form of altered taste sensation in which the affected person perceives a taste, usually an unpleasant one, in the absence of a corresponding stimulus in the environment.
http://purl.obolibrary.org/obo/HP_0033848	Receptive aphasia	http://purl.obolibrary.org/obo/HP_0002381	Aphasia		A type of aphasia that is characterized by impaired language comprehension.
http://purl.obolibrary.org/obo/HP_0033849	Bilingual aphasia	http://purl.obolibrary.org/obo/HP_0002381	Aphasia		The term bilingual aphasia is used to refer to aphasia in persons who speak two or more languages. When a multilingual speaker has aphasia following a stroke, the languages spoken premorbidly may show comparable or differential patterns of impairment. Differential patterns may manifest as greater impairment in one language compared to another, or as differences in the characteristics of aphasia. Clinical reports of bilingual aphasia show dissociations in the processing of the language learned first (L1) and and second (L2), with one language more impaired than the other. Other cases show a pattern of differential recovery where L2 is recovered only after L1. Another pattern is alternating antagonism; i.e., patients access one language in spontaneous speech and inhibit the other language for alternating periods. This term should be used for a type of aphasia in a person who speaks multiple languages in which the impairment is different for different languages.
http://purl.obolibrary.org/obo/HP_0033850	Coldness	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Relative coldness of a body part to palpitation, often acccompanied by feelings of coldness.
http://purl.obolibrary.org/obo/HP_0033851	Oculomotor synkinesis	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Elevation of the upper eyelid on attempted downward gaze or adduction, adduction of the eye on attempted upward or downward gaze, and constriction of the pupil on attempted adduction.
http://purl.obolibrary.org/obo/HP_0033852	Abnormal intrarenal vein morphology	http://purl.obolibrary.org/obo/HP_0033835	Abnormal renal vascular morphology		Abnormal structure of a vein located inside the kidney parenchyma.
http://purl.obolibrary.org/obo/HP_0033853	Abnormal arcuate vein morphology	http://purl.obolibrary.org/obo/HP_0033852	Abnormal intrarenal vein morphology		Any structural anomaly of the arcuate vein. The arcuate veins cross traverse along the corticomedullary junction (at the border of the kideny cortex and medulla).
http://purl.obolibrary.org/obo/HP_0033854	Abnormal interlobular vein morphology	http://purl.obolibrary.org/obo/HP_0033852	Abnormal intrarenal vein morphology		Any structural anomaly of the interlobular veins of the kidney. An interlobular vein is surrounded by the renal cortex and located between renal lobules (consisting of the nephrons surrounding a single medullary ray and draining into a single collecting duct).
http://purl.obolibrary.org/obo/HP_0033855	Abnormal interlobular vein lumen morphology	http://purl.obolibrary.org/obo/HP_0033854	Abnormal interlobular vein morphology		Any structural anomaly located in the the inside space of the interlobular veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033856	Cholesterol emboli within interlobular vein lumen	http://purl.obolibrary.org/obo/HP_0033855	Abnormal interlobular vein lumen morphology		Needle-like or slit-like clefts within the interior space of interlobular veins. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.
http://purl.obolibrary.org/obo/HP_0033857	Intraluminal thrombi within interlobular veins	http://purl.obolibrary.org/obo/HP_0033855	Abnormal interlobular vein lumen morphology		Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen of the interlobular veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033858	Organized thrombi within interlobular vein lumen	http://purl.obolibrary.org/obo/HP_0033855	Abnormal interlobular vein lumen morphology		Thrombi containing fibrous tissue and capillary-like vascular channels located within the lumen of the interlobular veins of the kidney.
http://purl.obolibrary.org/obo/HP_0041093	Beau's lines	http://purl.obolibrary.org/obo/HP_0025757	Abnormal nail surface		A nail dystrophy that is preseents as grooved lines that run from side to side on the fingernail or the toenail that may look like indentations or ridges on the nail plate. They are caused by temporary disruption in the growth of proximal nail matrix. Trauma is usually the initiating factor such as infections, severe medical illnesses, major surgery/anesthesia, medication side effects, and autoimmune disease.
http://purl.obolibrary.org/obo/HP_4000001	Abnormal cardiac magnetic resonance imaging finding	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Abnormal finding by magnetic resonance imaging (MRI), which uses non-ionizing radiation via a strong magnetic field and radio frequency energy to generate three dimensional images. This term comprises findings that are specific to MRI. Findings such as ventricular spetum defect that can be detected by multiple modalities should be coded separately.
http://purl.obolibrary.org/obo/HP_4000003	Elevated myocardial native T2	http://purl.obolibrary.org/obo/HP_4000001	Abnormal cardiac magnetic resonance imaging finding		Increased duration of myocardial T2 time without gadolinium contrast. Elevated T2, which can detect myocardial edema.
http://purl.obolibrary.org/obo/HP_4000004	Myocardial late gadolinium enhancement	http://purl.obolibrary.org/obo/HP_4000001	Abnormal cardiac magnetic resonance imaging finding		Areas of high signal intensity in magnetic resonance imaging of the heart appearing 10 to 15 minutes after injection of the intercellular contrast agent gadolinium.
http://purl.obolibrary.org/obo/HP_4000005	Pericardial late gadolinium enhancement	http://purl.obolibrary.org/obo/HP_0001697	Abnormal pericardium morphology		Areas of high signal intensity in magnetic resonance imaging of the pericardium appearing around 10 minutes after injection of the intercellular contrast agent gadolinium.
http://purl.obolibrary.org/obo/HP_4000006	Elevated myocardial native T1	http://purl.obolibrary.org/obo/HP_4000001	Abnormal cardiac magnetic resonance imaging finding		Increased duration of myocardial T1 time without gadolinium contrast. T1 mapping consists of quantifying the T1 relaxation time of a tissue by using analytical expressions of image-based signal intensities. A fundamental principle of MR imaging is that the signal intensity of pixels is based on the relaxation of hydrogen nuclei protons in a static magnetic field. The T1 relaxation times between two tissues vary substantially. Edema, fat infiltration, and fibrosis also cause differences in T1 relaxivity.
http://purl.obolibrary.org/obo/HP_4000007	Bronchoconstriction	http://purl.obolibrary.org/obo/HP_0025427	Abnormal bronchus physiology		Tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath.
http://purl.obolibrary.org/obo/HP_4000008	Formation of multiple pronuclei during fertilization	http://purl.obolibrary.org/obo/HP_0033335	Abnormal preimplantation embryonic development		Pronuclei formation is a critical process during fertilization. Normally, there are two pronuclei (2PN), including the paternal pronucleus and the maternal pronucleus, in the zygote after fertilization. It is generally accepted that multiple pronuclei (MPN) formation is due to the abnormal extrusion of the second polar body or to abnormal fertilization with multiple sperm. The MPN therefore can cause infertility and recurrent failure of IVF/ICSI.
http://purl.obolibrary.org/obo/HP_4000009	Kinesiophobia	http://purl.obolibrary.org/obo/HP_5200232	Phobia		An excessive, irrational, and debilitating fear of carrying out a physical movement due to a feeling of vulnerability to painful injury or reinjury.
http://purl.obolibrary.org/obo/HP_4000010	Impaired renal tubular reabsorption of bicarbonate	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Decreased renal tubular reabsorption of bicarbonate.
http://purl.obolibrary.org/obo/HP_4000011	History of congenital HPV infection	http://purl.obolibrary.org/obo/HP_0033623	Birth history		A congenital human papillomavirus (HPV) infection of the newborn. Congential HPV infection can manifest as condyloma cuminata in the newborn.
http://purl.obolibrary.org/obo/HP_4000013	Anti-desmoglein-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against desmoglein-1, a dermal cell adhesion molecule.
http://purl.obolibrary.org/obo/HP_4000014	Anti-desmoglein-3 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against desmoglein-3, a dermal cell adhesion molecule.
http://purl.obolibrary.org/obo/HP_4000015	Anti-envoplakin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against envoplakin, a cytoskeletal linker protein that links intermediate filaments to cellular junctions.
http://purl.obolibrary.org/obo/HP_4000016	Anti-periplakin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against periplakin.
http://purl.obolibrary.org/obo/HP_4000017	Anti-desmoplakin I antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against desmoplakin-1.
http://purl.obolibrary.org/obo/HP_4000018	Anti-desmoplakin II antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against desmoplakin-II.
http://purl.obolibrary.org/obo/HP_4000019	Anti-BP230 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against BP230.
http://purl.obolibrary.org/obo/HP_4000020	Anti-BP180 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against BP180.
http://purl.obolibrary.org/obo/HP_4000021	Anti-laminin 332 antibody positivity	http://purl.obolibrary.org/obo/HP_4000024	Anti-laminin antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against laminin-332.
http://purl.obolibrary.org/obo/HP_4000022	Anti-laminin 6 antibody positivity	http://purl.obolibrary.org/obo/HP_4000024	Anti-laminin antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against laminin-6.
http://purl.obolibrary.org/obo/HP_4000023	Anti-laminin gamma1 antibody positivity	http://purl.obolibrary.org/obo/HP_4000024	Anti-laminin antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against laminin gamma-1.
http://purl.obolibrary.org/obo/HP_4000024	Anti-laminin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against a laminin. Laminins are major components of the basement membrane.
http://purl.obolibrary.org/obo/HP_4000025	Anti-integrin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against an integrin. Integrins are a family of cell adhesion molecules with 24 known integrin heterodimers. Integrins transduce mechanical and biochemical signals from fibrotic extracellular matrix into the cell, activate latent TGFbeta, and subsequently modulate fibroblast adhesion, migration, and growth.
http://purl.obolibrary.org/obo/HP_4000026	Anti-transglutaminase 6 antibody	http://purl.obolibrary.org/obo/HP_0033563	Anti-tissue transglutaminase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against transglutaminase 6.
http://purl.obolibrary.org/obo/HP_4000027	Anti-LAD-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against LAD-1, which is the soluble 120 kDa ectodomain of BP180.
http://purl.obolibrary.org/obo/HP_4000028	Anti-LABD97 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against LABD97, which is structurally identical to a portion of the extracellular domain of BPAg2. BPAg2, a 180 kDa bullous pemphigoid antigen, is a transmembrane protein important for basement membrane cohesion.
http://purl.obolibrary.org/obo/HP_4000029	Antigliadin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against gliadin.
http://purl.obolibrary.org/obo/HP_4000030	Anti-reticulin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against reticulin.
http://purl.obolibrary.org/obo/HP_4000031	Anti-type VII collagen antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against collagen type VII.
http://purl.obolibrary.org/obo/HP_4000032	False perception of self-motion	http://purl.obolibrary.org/obo/HP_0001751	Abnormal vestibular function		A perception that one's body is moving or swaying despite lack of motion of the body.
http://purl.obolibrary.org/obo/HP_4000033	Non-spinning vertigo	http://purl.obolibrary.org/obo/HP_0001751	Abnormal vestibular function		A perception of unsteadiness of dizziness that is not characterized bythe spinning sensation of classic vertigo, but rather by an oscillatory perception (rocking, bobbing, or swaying despite the fact that the subject is not moving).
http://purl.obolibrary.org/obo/HP_4000034	Infection-associated lymphopenia	http://purl.obolibrary.org/obo/HP_0001888	Decreased total lymphocyte count		Decreased lymphocyte count during infections.
http://purl.obolibrary.org/obo/HP_4000035	Primary obstructive megaureter	http://purl.obolibrary.org/obo/HP_0000072	Hydroureter		Megaurater associated with obstruction or an adynamic ureteral segment in the ureterovesical junction.
http://purl.obolibrary.org/obo/HP_4000036	Encysted hydrocele of the cord	http://purl.obolibrary.org/obo/HP_0000034	Hydrocele testis		A type of hydrocele testis in which both the proximal and distal portions of processus vaginalis get obliterated while the central portion remains patent and fluid accumulates within it.
http://purl.obolibrary.org/obo/HP_4000037	Congenital hydrocele	http://purl.obolibrary.org/obo/HP_0000034	Hydrocele testis		Congenital hydrocele occurs when processus vaginalis is patent and communicates with the peritoneal cavity. This communication allows the movement of peritoneal fluid but is too small to allow the intra-abdominal contents to herniate through.
http://purl.obolibrary.org/obo/HP_4000038	Infantile hydrocele	http://purl.obolibrary.org/obo/HP_0000034	Hydrocele testis		Infantile Hydrocele is a type pf hydrocele in which the processus vaginalis gets obliterated at the level of the deep inguinal ring. However, the portion distal to it remains patent and allows fluid accumulation.
http://purl.obolibrary.org/obo/HP_4000039	Decreased mucosal-associated invariant T cell proportion	http://purl.obolibrary.org/obo/HP_0020340	Abnormal mucosal-associated invariant T cell proportion		A decreased proportion of circulating mucosal-associated invariant T (MAIT) cells relative to total T cell count.
http://purl.obolibrary.org/obo/HP_4000040	Puerpural onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		Onset of a phenotypic abnormality or a disease during childbirth or in the period immediately following.
http://purl.obolibrary.org/obo/HP_4000041	AA amyloidosis	http://purl.obolibrary.org/obo/HP_0011034	Amyloid deposition		Extracellular tissue deposition of fibrils that are composed of fragments of and/or intact serum amyloid A protein, a hepatic acute phase reactant.
http://purl.obolibrary.org/obo/HP_4000042	Fracture type	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		Category of fracture. Terms from this subontology can be used together with terms in the subontology that descends from Bone fracture (HP:0020110).
http://purl.obolibrary.org/obo/HP_4000043	Greenstick fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the broken bone is not completely separated.
http://purl.obolibrary.org/obo/HP_4000044	Transverse fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the break is in a straight line across the bone.
http://purl.obolibrary.org/obo/HP_4000045	Spiral fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the break spirals around the bone.
http://purl.obolibrary.org/obo/HP_4000046	Oblique fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which there is a diagonal break across the bone.
http://purl.obolibrary.org/obo/HP_4000047	Compression fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the bone is crushed, causing the broken bone to be wider or flatter in appearance.
http://purl.obolibrary.org/obo/HP_4000048	Comminuted fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the break is in three or more pieces and fragments are present at the fracture site.
http://purl.obolibrary.org/obo/HP_4000049	Segmental fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the same bone is fractured in two places, so there is a floating segment of bone.
http://purl.obolibrary.org/obo/HP_4000050	Open fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which there is an open wound or break in the skin near the site of the broken bone.
http://purl.obolibrary.org/obo/HP_4000051	Closed fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the broken bone that does not penetrate the skin.
http://purl.obolibrary.org/obo/HP_4000052	Avulsion fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture that is localied near to a a tendon or ligament and a small fragment of bone is separated from the main mass of bone as a result of physical trauma.
http://purl.obolibrary.org/obo/HP_4000053	Displaced fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture in which the ends of the fractured bone are no longer aligned.
http://purl.obolibrary.org/obo/HP_4000055	Intestinal inflammation	http://purl.obolibrary.org/obo/HP_0004386	Gastrointestinal inflammation		A reaction characterizeds by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling localized to the in the intestinal tract.
http://purl.obolibrary.org/obo/HP_4000056	Abnormal apoptosis	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		Any abnormality of programmed cell death (apoptosis), which is defined as the orchestrated collapse of a cell characterized by membrane blebbing, cell shrinkage, condensation of chromatin, and fragmentation of DNA followed by rapid engulfment of the corpse by neighboring cells. Apoptosis is distinguished from death by necrosis by the absence of an associated inflammatory response.
http://purl.obolibrary.org/obo/HP_4000057	Decreased FasL-mediated apoptosis	http://purl.obolibrary.org/obo/HP_4000056	Abnormal apoptosis		A reduced amount of programmed cell death upon stimulation of the FAS receptor, which normally induces caspase-8 dependent apoptosis.
http://purl.obolibrary.org/obo/HP_4000058	Glomerular proteinuria	http://purl.obolibrary.org/obo/HP_0000093	Proteinuria		A type of proteinuria characterized by increased permeability of the glomerular capillary wall to macromolecules (particularly albumin), whereby protein excretion can reach 20 g/24 h and consists mainly of albumin.
http://purl.obolibrary.org/obo/CHEBI_189846	dicarboxylic fatty acid dianion	http://purl.obolibrary.org/obo/CHEBI_61697	fatty acid derivative		Any fatty acid that contains 2 carboxylic groups. Major microspecies at pH 7.3
http://purl.obolibrary.org/obo/UBERON_8470000	placental blood	http://purl.obolibrary.org/obo/UBERON_0000178	blood		Blood located in the placenta.
http://purl.obolibrary.org/obo/HP_0034794	Pyriform sperm head	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Pyriform spermatozoa consist of a normally shaped acrosomal structure which can be normal in size or enlarged, while the post-acrosomal region shows severe elongation and an acute narrowing to the posterior end, ending in about the same thickness as the connecting mid-piece.
http://purl.obolibrary.org/obo/HP_0034795	Excess residual spermatozoal cytoplasm	http://purl.obolibrary.org/obo/HP_0012864	Abnormal sperm morphology		Excess residual cytoplasm is associated with abnormal spermatozoa produced from a defective spermiation process. This abnormal excess cytoplasm should not be confused with more physiological cytoplasmic residues that can be observed in direct microscopy of the ejaculate but not in dried, fixed and stained morphology smears.
http://purl.obolibrary.org/obo/HP_0034796	Cardiomyocyte hyaline bodies	http://purl.obolibrary.org/obo/HP_0031334	Cardiomyocyte inclusion bodies		Subsarcolemmal, eosinophilic glass-like regions within the cytoplasm of cardiomyocytes.
http://purl.obolibrary.org/obo/HP_0034797	Hepatic hemophagocytosis	http://purl.obolibrary.org/obo/HP_0012156	Hemophagocytosis		Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the liver.
http://purl.obolibrary.org/obo/HP_0034798	CSF hemophagocytosis	http://purl.obolibrary.org/obo/HP_0012156	Hemophagocytosis		Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0034799	Splenic hemophagocytosis	http://purl.obolibrary.org/obo/HP_0012156	Hemophagocytosis		Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the spleen.
http://purl.obolibrary.org/obo/HP_0034800	Urinary bladder granulomatosis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		The presence of multiple granulomas in the urinary bladder as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes.
http://purl.obolibrary.org/obo/HP_0034801	Epidermal necrosis	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Death of keratinocytes in the epidermis layer of the skin, which generally manifests as extensive exfoliation (separation of the epidermis from the underlying dermis).
http://purl.obolibrary.org/obo/HP_0034802	Exacerbated by flexion	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is aggravated by (or made more painful by) bending of a limb or joint.
http://purl.obolibrary.org/obo/HP_0034803	Hemolacria	http://purl.obolibrary.org/obo/HP_0000632	Lacrimation abnormality		The presence of blood in tears.
http://purl.obolibrary.org/obo/HP_0034804	Corneal foreign body sensation	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		A perception that an object is in contact with the eye.
http://purl.obolibrary.org/obo/HP_0034805	Buttock pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the buttock (round fleshy area at the lower rear area of a human trunk).
http://purl.obolibrary.org/obo/HP_0034806	Vaginal foreign body sensation	http://purl.obolibrary.org/obo/HP_0034268	Abnormal vaginal physiology		A perception that an object located in the vagina.
http://purl.obolibrary.org/obo/HP_0034807	Paroxysmal nocturnal dyspnea	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		Attacks of breathlessness that occur at night and may awaken the sleeping patient.
http://purl.obolibrary.org/obo/HP_0034808	Eyelid pain	http://purl.obolibrary.org/obo/HP_0031879	Abnormal eyelid physiology		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eyelid.
http://purl.obolibrary.org/obo/HP_0034810	Small acrosomal area	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Reduction in size of the acrosome below the lower limit of normal. The acrosome is a unique membranous organelle located over the anterior part of the sperm nucleus. According to the World Health Organization criteria, the acrosome must be clearly visible, comprising approximately 40-70 percent of the sperm head.
http://purl.obolibrary.org/obo/HP_0034811	Bent sperm flagella	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		The proportion of sperm cells whose flagella is sharply curved or has a sharp angle is above normal limits.
http://purl.obolibrary.org/obo/HP_0034812	Spermiation failure	http://purl.obolibrary.org/obo/HP_0011961	Non-obstructive azoospermia		Spermiation failure is indicated by apparently normal spermiogenesis, but the presence of retained Sd2 spermatids in stages III-V of human spermatogenesis, whereas maturation arrest is indicated by a lack of late Sd1 and Sd2 spermatids in the epithelium.
http://purl.obolibrary.org/obo/HP_0034813	Hypospermatogenesis	http://purl.obolibrary.org/obo/HP_0008669	Abnormal spermatogenesis		A morphological abnormality visible upon biopsy of the germinal epithelium of the testis in which the cellularity of the germinal epithelium is reduced in general, so that all stages of germ cells (spermatogonia, spermatocytes, and spermatids) are present but reduced in number. This term applies to biopsies with some tubules showing diminished amounts of qualitatively complete spermatogenesis in combination with a vast majority of tubules that lack germ cells.
http://purl.obolibrary.org/obo/HP_0034814	Conjunctival membrane	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Formation of a sheet of tissue by coagulum of exudate over the conjunctiva of the eye that if removed leaves behind a denuded bleeding surface.
http://purl.obolibrary.org/obo/HP_0034815	Extreme oligozoospermia	http://purl.obolibrary.org/obo/HP_0000798	Oligozoospermia		A type of oligozoospermia characterized by a total number of more than zero but less than 2 million sperm in the ejaculate or a concentration of more than zero but less than one million sperm per milliliter.
http://purl.obolibrary.org/obo/HP_0034816	Mild oligozoospermia	http://purl.obolibrary.org/obo/HP_0000798	Oligozoospermia		A type of oligozoospermia characterized by a total number of more than 30 but less than 39 million sperm in the ejaculate or a concentration of more than 10 but less than 15 million sperm per milliliter.
http://purl.obolibrary.org/obo/HP_0034817	Moderate oligozoospermia	http://purl.obolibrary.org/obo/HP_0000798	Oligozoospermia		A type of oligozoospermia characterized by a total number of more than 10 but less than 29 million sperm in the ejaculate or a concentration of more than 5 but less than 10 million sperm per milliliter.
http://purl.obolibrary.org/obo/HP_0034818	Severe oligozoospermia	http://purl.obolibrary.org/obo/HP_0000798	Oligozoospermia		A type of oligozoospermia characterized by a total number of more than 2 but less than 10 million sperm in the ejaculate or a concentration of more than 1 but less than 5 million sperm per milliliter.
http://purl.obolibrary.org/obo/HP_0034820	Koeppe nodules	http://purl.obolibrary.org/obo/HP_0034819	Iris nodule		A type of iris nodule consisting of inflammatory cell precipitates which lie at the pupillary margin.
http://purl.obolibrary.org/obo/HP_0034821	Bussaca nodules	http://purl.obolibrary.org/obo/HP_0034819	Iris nodule		A type of iris nodule consisting of inflammatory cell precipitates which lie on the iris surface.
http://purl.obolibrary.org/obo/HP_0034823	Decreased CSF copper concentration	http://purl.obolibrary.org/obo/HP_0034822	Abnormal CSF ion concentration		Concentration of copper in the cerebrospinal fluid (CSF) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034824	Diffuse pulmonary lymphoid hyperplasia	http://purl.obolibrary.org/obo/HP_0033582	Pulmonary interstitial lymphocyte infiltration		Diffuse lymphoid hyperplasia (DLH) describes the pathological entity that lies between follicular bronchiolitis and lymphocytic interstitial pneumonia (LIP). It is pathologically characterized by a diffuse peribronchiolar proliferation of hyperplastic lymphoid follicles (BALT), extended along the lymphatics to involve the interlobular septa and pleura. Unlike LIP, DHL does not show uniform involvement of the alveolar septa.
http://purl.obolibrary.org/obo/HP_0034825	Ameliorated by steroid medication	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with a steroid medication such as prednisone.
http://purl.obolibrary.org/obo/HP_0034827	Triggered by levothyroxin exposure	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by administration of levothyroxin (thyroid hormone).
http://purl.obolibrary.org/obo/HP_0034828	Reduced muscle laminin alpha-2 chain staining	http://purl.obolibrary.org/obo/HP_0034510	Abnormal muscle tissue enzyme activity or level		A decreased amount of laminin alpha-2 chain in muscle tissue. This feature can be shown by immunohistochemistry or Western blotting of muscle tissue.
http://purl.obolibrary.org/obo/HP_0034829	Adrenal cortical sclerosis	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Abnormal thickening of of the outer layer (cortex) of the adrenal gland due to fibrosis.
http://purl.obolibrary.org/obo/HP_0034830	Reduced hepatic fructose-1,6-phosphate aldolase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Concentration or activity of fructose 1,6-bisphosphate aldolase in liver tissue below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034831	Pancreatic hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the pancreas.
http://purl.obolibrary.org/obo/HP_0034832	Liver angiomyolipoma	http://purl.obolibrary.org/obo/HP_0034514	Liver hamartoma		A benign liver neoplasm composed of fat, vascular, and smooth muscle elements.
http://purl.obolibrary.org/obo/HP_0034833	Cardiac lipoma	http://purl.obolibrary.org/obo/HP_0012032	Lipoma		A lipoma that is located within a the heart.
http://purl.obolibrary.org/obo/HP_0034834	Peripheral nerve polyglucosan inclusion bodies	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in peripheral nerve fibers.
http://purl.obolibrary.org/obo/HP_0034835	Cardiac polyglucosan accumulation	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in myocardial tissue.
http://purl.obolibrary.org/obo/HP_0034836	Cystic nephroma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		A benign cystic neoplasm of the kidney.
http://purl.obolibrary.org/obo/HP_0034837	Absent dermal elastic fibers	http://purl.obolibrary.org/obo/HP_0025082	Abnormal cutaneous elastic fiber morphology		Elastic fibers not demonstrable in skin biopsy.
http://purl.obolibrary.org/obo/HP_0034838	Cleavage at junction of stratum corneum and stratum granulosum	http://purl.obolibrary.org/obo/HP_0033802	Intra-epidermal blistering		Splitting of the skin (cell-cell adhesion of keratinocytes) localized to the interface between the stratum corneum and stratum granulosum layers of the epidermis.
http://purl.obolibrary.org/obo/HP_0034839	Lymphoid hyperplasia	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		An abnormal bone marrow finding characterized by many poorly circumscribed and occasionally confluent lymphoid nodules. The nodules contain small and uniform lymphocytes with rounded nuclei, clumped chromatin, and without prominent nucleoli.
http://purl.obolibrary.org/obo/HP_0034840	Absence of epidermal lamellar bodies	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Lack of lamellar bodies (LBs) inthe epidermis. LBs are specialized organelles that contain pro-barrier lipids imparting a fully lamellar internal structure, but also other cargoes such as enzymes (lipid metabolizing and proteolytic), enzyme inhibitors, and antimicrobial peptides.
http://purl.obolibrary.org/obo/HP_0034841	Gastrointestinal granulomatosis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		The presence of multiple granulomas in the gastrointestinal tract (Pylorus, esophagus, jejunum, ileum, cecum, rectum, perirectal area, esophagus) as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes.
http://purl.obolibrary.org/obo/HP_0034842	Enlarged sperm head vacuole	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Increased size of sperm vacuoles, which are surface concavities typically located at the the tip or middle area of sperm heads. According to the WHO Laboratory Manual for the Examination and Processing of Human Semen, sperm head vacuoles are considered abnormal when exceeding 20% of the cross-sectional area of the head. Vacuoles are found in almost all samples with normal sperm morphology; this term applies if the proportion of sperm with abnormally large vacuoles is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034843	Ureteral hamartoma	http://purl.obolibrary.org/obo/HP_0100516	Neoplasm of the ureter		A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the ureter.
http://purl.obolibrary.org/obo/HP_0034844	Fetal methimazole exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to methimazole.
http://purl.obolibrary.org/obo/HP_0034845	Fetal procarbazine exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to procarbazine.
http://purl.obolibrary.org/obo/HP_0034846	Fetal fluorouracil exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to fluorouracil.
http://purl.obolibrary.org/obo/HP_0034847	Fetal cytarabine exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to cytarabine.
http://purl.obolibrary.org/obo/HP_0034848	Fetal tetracycline exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to tetracycline.
http://purl.obolibrary.org/obo/HP_0034849	Fetal quinine exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to quinine.
http://purl.obolibrary.org/obo/HP_0034850	Fetal cyclophosphamide exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to cyclophosphamide.
http://purl.obolibrary.org/obo/HP_0034851	Fetal metronidazole exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to metronidazole.
http://purl.obolibrary.org/obo/HP_0034852	Fetal phenobarbital exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to phenobarbital.
http://purl.obolibrary.org/obo/HP_0034853	Fetal phenytoin exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to phenytoin.
http://purl.obolibrary.org/obo/HP_0034854	Periumbilical	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance are located at or near the umbilicus (belly button).
http://purl.obolibrary.org/obo/HP_0034855	Maternal obesity during pregnancy	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		A history of obesity, which can be defined as a body mass index of 30 or greater, in the mother of a fetus or index patient.
http://purl.obolibrary.org/obo/HP_0034856	Maternal amniocentesis	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		A history of amniocentesis having been performed in the mother of a fetus or index patient.
http://purl.obolibrary.org/obo/HP_0034857	Typified by highly variable age of onset	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Description of conditions in which age of onset is highly variable even in family members who share the same disease-associated variant or variants.
http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity	http://purl.obolibrary.org/obo/HP_0034684	Abnormal enzyme concentration or activity		Concentration or activity of an enzyme as measured in leukocytes is above or below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034859	Reduced tissue beta-glucuronidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of beta-glucuronidase (EC 3.2.1.31) below the lower limit of normal. FECH enzyme can be measured in multiple tissues including cultured fibroblasts and leukocytes.
http://purl.obolibrary.org/obo/HP_0034860	Reduced leukocyte alpha-L-fucosidase activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of an alpha-L-fucosidase as measured in leukocytes is below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034861	Reduced leukocyte arylsulfatase B activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of an arylsulfatase B as measured in leukocytes is below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034862	Reduced leukocyte steroid sulfatase activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of an arylsulfatase C as measured in leukocytes is below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034863	Reduced leukocyte arylsulfatase A activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of the lysosomal enzyme arylsulfatase A (EC 3.1.6.8) as measured in leukocytes is below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034864	Decreased alpha-galactosidase A activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme alpha-galactosidase below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034865	Positive fecal parasite test	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Demonstration of parasite in stool specimen, e.g., Parasites present on wet mount of stool.e
http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Any kind of test for an infectious agent in stool positive.
http://purl.obolibrary.org/obo/HP_0034867	Positive stool giardia antigen	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Test for giardia antigen in stool such as immune assay or DFA positive.
http://purl.obolibrary.org/obo/HP_0034868	Entamoeba histolytica antibody positive in stool	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Demonstration of antibody directed against Entamoeba histolytica in stool.
http://purl.obolibrary.org/obo/HP_0034869	Reduced erythrocyte free porphyrin concentration	http://purl.obolibrary.org/obo/HP_0010472	Abnormal circulating porphyrin concentration		Concentration of porphyrin in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034870	Reduced circulating urocanic acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of urocanic acid in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034871	Decreased urinary epinephrine level	http://purl.obolibrary.org/obo/HP_0045012	Decreased urinary catecholamine concentration		The concentration of epinephrine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034872	Decreased CSF epinephrine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Concentration of epinephrine in the cerebrospinal fluid below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034873	Decreased circulating epinephrine concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of epinephrin in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034874	Decreased circulating norepinephrine concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of norepinephrin in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034875	Decreased urinary norepinephrine level	http://purl.obolibrary.org/obo/HP_0045012	Decreased urinary catecholamine concentration		The concentration of norepinephrine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034876	Decreased urinary metaepinephrine level	http://purl.obolibrary.org/obo/HP_0045012	Decreased urinary catecholamine concentration		The concentration of metanephrine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034877	Decreased CSF metanephrine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Concentration of metanephrine in the cerebrospinal fluid below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034878	Decreased circulating metanephrine concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of metanephrin in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034879	Ovarian mass	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		A swelling or enlargement localized to the ovary. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034880	Adrenal mass	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		A swelling or enlargement localized to the adrenal gland. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034881	Uterine mass	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		A swelling or enlargement localized to the uterus. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034882	Prostatic calculus	http://purl.obolibrary.org/obo/HP_0008775	Abnormal prostate morphology		Calcium deposits in the prostate gland.
http://purl.obolibrary.org/obo/HP_0034883	Decreased portal vein velocity	http://purl.obolibrary.org/obo/HP_0031865	Abnormal liver physiology		A reduction in the velocity of portal venous flow, generally measured by Doppler ultrasound. Portal venous flow is normally towards the liver with peak systolic velocities in the range of 20-40 cm/s.
http://purl.obolibrary.org/obo/HP_0034884	Uterine cervix mass	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		A swelling or enlargement localized to the cervis of the uterus. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034885	Abnormal urinary uromodulin level	http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level		The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for usine concentration, is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0034886	Decreased urinary uromodulin level	http://purl.obolibrary.org/obo/HP_0034885	Abnormal urinary uromodulin level		The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034887	Increased urine phenylacetylglutamine level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		The concentration of phenylacetylglutamine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034888	Decreased urine guanidinoacetic acid level	http://purl.obolibrary.org/obo/HP_0040418	Abnormal urine guanidinoacetic acid level		The concentration of guanidinoacetic acid in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034889	Positive urine infectious agent nucleic acid test	http://purl.obolibrary.org/obo/HP_0025795	Positive urine infectious agent test		Detection of DNA and RNA originating from an infectious agent (bacteria, viruses, parasites and fungi) in the urine.
http://purl.obolibrary.org/obo/HP_0034890	Positive CMV urine nucleic acid test	http://purl.obolibrary.org/obo/HP_0034889	Positive urine infectious agent nucleic acid test		Detection of Cytomegalovirus (CMV) nucleic acid in the urine by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_0034891	Positive Neisseria gonorrhoeae urine nucleic acid test	http://purl.obolibrary.org/obo/HP_0034889	Positive urine infectious agent nucleic acid test		Detection of Neisseria gonorrhoeae nucleic acid in the urine by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_0034892	Positive enterovirus urine nucleic acid test	http://purl.obolibrary.org/obo/HP_0034889	Positive urine infectious agent nucleic acid test		Detection of enterovirus nucleic acid in the urine by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_0034893	Elevated brain glycine level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An increase in the level of glycine in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0034894	Elevated brain polyol compounds by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An increase in the level of polyol compounds in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0034895	Elevated brain gamma-aminobutyric acid by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An increase in the level of gamma-aminobutyric acid (GABA) in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0034896	History of recent anticoagulant ingestion	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of ingestion of anticoagulants prior to presentation.
http://purl.obolibrary.org/obo/HP_0034897	Decreased circulating antidiuretic hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of antidiuretic hormone, also known as vasopressin, is below the lower limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034898	Elevated circulating growth hormone-releasing hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of growth hormone-releasing hormone above the upper limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034899	Abnormal amniotic fluid protein concentration	http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid		Any deviation of the concentration of a protein in the amniotic fluid from normal limits
http://purl.obolibrary.org/obo/HP_0034900	Decreased amniotic fluid alpha-fetoprotein concentration	http://purl.obolibrary.org/obo/HP_0034899	Abnormal amniotic fluid protein concentration		Concentration of alpha-fetoprotein in the amniotic fluid below lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034901	Increased circulating vitamin E concentration	http://purl.obolibrary.org/obo/HP_0100514	Abnormal circulating vitamin E concentration		Concentration of vitamin E in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034903	Decreased circulating calcitonin concentration	http://purl.obolibrary.org/obo/HP_0034902	Abnormal circulating calcitonin concentration		Concentration of calcitonin, a 32-amino acid polypeptide hormone that is produced primarily by the parafollicular cells of the thyroid, in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034904	Decreased circulating thyrotropin releasing hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of thyrotropin releasing hormone below the lower limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034905	Elevated circulating uroporphyrin concentration	http://purl.obolibrary.org/obo/HP_0034606	Elevated circulating porphyrin concentration		Concentration of uroporphyrin in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034906	Increased urine pentacarboxylporphyrin level	http://purl.obolibrary.org/obo/HP_0010473	Porphyrinuria		Concentration of pentacarboxylporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034907	Increased urine hexacarboxylporphyrin level	http://purl.obolibrary.org/obo/HP_0010473	Porphyrinuria		Concentration of hexacarboxylporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034908	Increased circulating dehydroepiandrosterone concentration	http://purl.obolibrary.org/obo/HP_0500022	Abnormal circulating dehydroepiandrosterone concentration		Concentration of dehydroepiandrosterone in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034909	Increased erythrocyte coproporphyrin concentration	http://purl.obolibrary.org/obo/HP_0034606	Elevated circulating porphyrin concentration		Concentration of coproporphyrin in erythrocytes above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034910	Increased erythrocyte uroproporphyrin concentration	http://purl.obolibrary.org/obo/HP_0034606	Elevated circulating porphyrin concentration		Concentration of uroproporphyrin in erythrocytes above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034911	Decreased circulating apolipoprotein E concentration	http://purl.obolibrary.org/obo/HP_0033459	Decreased circulating apolipoprotein concentration		The concentration of apolipoprotein E in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034912	Elevated circulating apolipoprotein E concentration	http://purl.obolibrary.org/obo/HP_0033460	Elevated circulating apolipoprotein concentration		The concentration of apolipoprotein E in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034913	Acrosomal hypoplasia	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Reduction in the size of the acrosome of the head of spermatozoa.
http://purl.obolibrary.org/obo/HP_0034914	Oocyte maturation arrest	http://purl.obolibrary.org/obo/HP_0033338	Abnormal female meiosis		Oocyte maturation arrest (OMA) can manifest as failed in vitro fetilization/intracytoplasmic sperm injection (IVF/ICSI) attempts using affected oocytes.
http://purl.obolibrary.org/obo/HP_0034916	Abnormal anus physiology	http://purl.obolibrary.org/obo/HP_0004378	Abnormality of the anus		A functional anomaly of the anus.
http://purl.obolibrary.org/obo/HP_0034917	Weak anal sphincter tone	http://purl.obolibrary.org/obo/HP_0034916	Abnormal anus physiology		Reduced muscle tone of the sphincter of the anus.
http://purl.obolibrary.org/obo/HP_0034918	Reduced muscle 2,4-dienoyl-CoA reductase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Diminished activity of the enzyme 2,4-dienoyl-CoA reductase in muscle tissue.
http://purl.obolibrary.org/obo/HP_0034919	Reduced liver 2,4-dienoyl-CoA reductase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Diminished activity of the enzyme 2,4-dienoyl-CoA reductase in liver tissue.
http://purl.obolibrary.org/obo/HP_0034920	Nasal mucosa vasculitis	http://purl.obolibrary.org/obo/HP_0000433	Abnormal nasal mucosa morphology		Inflammation of blood vessels in the mucosa of the nasal cavity.
http://purl.obolibrary.org/obo/HP_0034921	Pituitary blastoma	http://purl.obolibrary.org/obo/HP_0011750	Neoplasm of the anterior pituitary		Pituitary blastoma is a distinctive anterior hypophyseal tumor of infants
http://purl.obolibrary.org/obo/HP_0034922	Peripheral axon spheroid formation	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Axonal spheroids are bubble-like biological features that form on most degenerating axons.
http://purl.obolibrary.org/obo/HP_0034923	Reduced liver carboxylesterase 1 activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of the enzyme carboxylesterase 1 in liver tissue below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		A structural anomaly of the dermis, the layer of skin that lies beneath the epidermis and above the subcutaneous layer.
http://purl.obolibrary.org/obo/HP_0034925	Perivascular dermis hyaline deposition	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Deposition of a largely amorphous hyaline (transparent and homogeneous) substance around blood vessels in the dermis layer of the skin.
http://purl.obolibrary.org/obo/HP_0034926	Perivascular small intestinal hyaline deposition	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		Deposition of a largely amorphous hyaline (transparent and homogeneous) substance around blood vessels in the wall of the small intestine.
http://purl.obolibrary.org/obo/HP_0034927	Large keratohyaline granules	http://purl.obolibrary.org/obo/HP_0034702	Abnormal keratinocyte morphology		Abnormally large keratohyalin granules (KHG). KHG are typically present in the stratum granulosum of the epidermal layer of the skin (and epithelium of the mucosae). KHG are protein structures found in the keratinocytes of the stratum granulosum.
http://purl.obolibrary.org/obo/HP_0034928	Decreased muscle lipoic acid content	http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration		Reduced amount of lipoic acid in muscle tissue.
http://purl.obolibrary.org/obo/HP_0034929	Reduced hepatic cystathionine gamma-lyase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of cystathionine gamma-lyase in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034931	Lumbar spondylosis	http://purl.obolibrary.org/obo/HP_0100712	Abnormal lumbar spine morphology		Arthrosis, i.e., of degenerative joint disease, affecting the lumbar vertebral column.
http://purl.obolibrary.org/obo/HP_0034932	Decreased circulating acid maltase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme acid maltase (also known as alpha-1,4-glucosidase) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034935	Decreased circulating 7-dehydrocholesterol concentration	http://purl.obolibrary.org/obo/HP_0034934	Abnormal circulating 7-dehydrocholesterol concentration		Concentration of 7-dehydrocholesterol in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034936	Elevated circulating lathosterol concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		Concentration of lathosterol in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034937	Elevated circulating desmosterol concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		Concentration of desmosterol in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034938	Decreased circulating sialic acid concentration	http://purl.obolibrary.org/obo/HP_0020347	Abnormal circulating monosaccharide concentration		Concentration of sialic acid in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034939	Purulent synovial fluid	http://purl.obolibrary.org/obo/HP_0025850	Abnormal synovial cavity morphology		The synovial fluid (also known as synovia, i.e., the fluid found in the cavities of synovial joints) contains increased quantities of white blood cells.
http://purl.obolibrary.org/obo/HP_0034940	Muscle fiber calsequestrin 1-containing inclusion bodies	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		The presence of inclusion bodies within the cytoplasm of muscle cells that demonstrate immunoreactivity for calsequestrin 1.
http://purl.obolibrary.org/obo/HP_0034941	Palatine myxoma	http://purl.obolibrary.org/obo/HP_0031366	Palate neoplasm		A myxoma (A benign tumor composed of myxomatous tissue composed of loosely-arranged spindle, polygonal, and stellate cells) localized to the palate. Clinically, such tumors may present as a sessile nodule on the hard palate.
http://purl.obolibrary.org/obo/HP_0034942	Vaginal myxoma	http://purl.obolibrary.org/obo/HP_0100650	Vaginal neoplasm		A myxoma (tumor of primitive connective tissue) localized in the vagina.
http://purl.obolibrary.org/obo/HP_0034943	Decreased dermal collagen	http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology		Abnormally reduced amount of collagen fibers in the dermis.
http://purl.obolibrary.org/obo/HP_0034944	Irregularly shaped keratohyaline granules	http://purl.obolibrary.org/obo/HP_0033806	Abnormal epidermis stratum granulosum morphology		Abnormal shape of keratohyaline granules in dermal keratinocytes.
http://purl.obolibrary.org/obo/HP_0034945	Tubular shadows	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Tubular shadows are characterized by a complete absence of cells in the testicular tubules, meaning that germ cells as well as somatic Sertoli cells are absent. The cells have been replaced by hyalinization.
http://purl.obolibrary.org/obo/HP_0034946	Multiple eyelid margin cysts	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Presence of many apocrine hidrocystoma (cysts) on the margins of the eyelids.
http://purl.obolibrary.org/obo/HP_0034947	Altered location of the longitudinal column in the fibrous sheath	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		The fibrous sheath is a structure in the midpiece of the sperm flagellum surrounding the outer dense fibers. It comprises two longitudinal columns and transverse ribs. In case of altered location of the longitudinal column in the fibrous sheath the symmetrical structure is lost, most commonly with the columns not being opposite to each other, which can be visualized by electron microscopy.
http://purl.obolibrary.org/obo/HP_0034948	Uterine myxoma	http://purl.obolibrary.org/obo/HP_0010784	Uterine neoplasm		A myxoma (tumor of primitive connective tissue) localized to the uterus.
http://purl.obolibrary.org/obo/HP_0034949	Uterine cervix myxoma	http://purl.obolibrary.org/obo/HP_0010784	Uterine neoplasm		A myxoma (tumor of primitive connective tissue) localized to the the cervix of the uterus.
http://purl.obolibrary.org/obo/HP_0034950	Typified by complete penetrance	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Penetrance describes the proportion of genotype positive individuals that develop disease given a lifespan of 80 years. For example, penetrance of Neurofibromatosis type 1 is close to 100%.
http://purl.obolibrary.org/obo/HP_0034951	Osteochondromyxoma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A rare benign chondroid and osteoid matrix-producing neoplasm of bone characterized by extensive myxoid changes. OMX originate from bony cortices and have been observed in the nasal region, as well as the tibia and radius.
http://purl.obolibrary.org/obo/HP_0034952	Gangliocytoma	http://purl.obolibrary.org/obo/HP_0030693	Supratentorial neoplasm		A low-grade central nervous system tumor composed of dysplastic ganglion cells, usually presenting in children or young adults and located in the cerebral hemispheres.
http://purl.obolibrary.org/obo/HP_0034953	Duodenal gastrinoma	http://purl.obolibrary.org/obo/HP_0100833	Neoplasm of the small intestine		A gastrinoma, a neuroendocrine tumors characterized by the secretion of gastrin with resultant excessive gastric acid production, that is localized to the duodenum.
http://purl.obolibrary.org/obo/HP_0034954	Thymic carcinoid tumor	http://purl.obolibrary.org/obo/HP_0100521	Neoplasm of the thymus		A primary thymic neuroendocrine tumor.
http://purl.obolibrary.org/obo/HP_0034955	Bone marrow eosinophilia	http://purl.obolibrary.org/obo/HP_0012135	Abnormal granulocytopoietic cell morphology		Count of eosinophils in the bone marrow above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034956	Exacerbated by lithium exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by treatment with lithium.
http://purl.obolibrary.org/obo/HP_0034957	Reduced hepatic glycogen debrancher enzyme activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of glycogen debrancher enzyme (also known as amylo-1,6-glucosydase, 4-alpha-glucantransferase) in liver tissue below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034958	Asymmetrical insertion of the midpiece into the head	http://purl.obolibrary.org/obo/HP_0012867	Abnormal sperm mid-piece morphology		Insertion of the neck and midpiece into the head of a spermatozoon on an axis that diverges from the midline axis of the spermatozoon head. This term applies if the proportion of spermatozoa with this defect is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034959	Bent sperm neck	http://purl.obolibrary.org/obo/HP_0012866	Abnormal sperm neck morphology		Sharply angled insertion of the neck and midpiece into the head of a spermatozoon. This term applies if the proportion of spermatozoa with this feature is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034960	Elevated urine 3,6-epoxydicarboxylic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of 3,6-epoxydicarboxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034961	Gallbladder biliary sludging	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Presence of biliary sludge (a mixture of particulate solids that have precipitated from bile) in the gallbladder. Such sediment consists of cholesterol crystals, calcium bilirubinate pigment, and other calcium salts. Sludge is usually detected on transabdominal ultrasonography.
http://purl.obolibrary.org/obo/HP_0034962	Exacerbated by amiodarone exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by treatment with amiodarone.
http://purl.obolibrary.org/obo/HP_0034963	Ureteral mass	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		A swelling or enlargement localized to the ureter. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034964	Wide cavum septum pellucidum	http://purl.obolibrary.org/obo/HP_0007375	Abnormal septum pellucidum morphology		Width of the cavum septum pellucidum above the upper limit of normal, which is defined as a separation of greater than one cm of the leaves of the cavum septum pellucidum.
http://purl.obolibrary.org/obo/HP_0034965	Hypoplastic trochlear nerve	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		Underdevelopment of the trochlear nerve, which is the fourth cranial nerve and one of the ocular motor nerves that controls eye movement.
http://purl.obolibrary.org/obo/HP_0034966	Thymic cyst	http://purl.obolibrary.org/obo/HP_0000777	Abnormal thymus morphology		A closed sac of tissue (cyst) located in the thymus. Thymic cysts are a rare, benign anomaly, are usually asymptomatic, and mostly occur in the anterior mediastinum .
http://purl.obolibrary.org/obo/HP_0034967	Uterine cyst	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		A closed sack of tissue (cyst) located in the uterus.
http://purl.obolibrary.org/obo/HP_0034968	Urinary bladder mass	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		A swelling or enlargement localized to the urinary bladder. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034969	Endosteal scalloping	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		A series of indentations or erosions on a normally smooth margin of the inner layer of the cortex (i.e. the endosteum) of bones.
http://purl.obolibrary.org/obo/HP_0034970	Urinary bladder hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the urinary bladder.
http://purl.obolibrary.org/obo/HP_0034971	Peritoneal mass	http://purl.obolibrary.org/obo/HP_0002585	Abnormal peritoneum morphology		A swelling or enlargement localized to the peritoneal cavity. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034972	Fallopian tube mass	http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology		A swelling or enlargement localized to the Fallopian tube. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0034973	Aplasia of the pyramids of the medulla oblongata	http://purl.obolibrary.org/obo/HP_0011441	Abnormal medulla oblongata morphology		Congenital absence of the pyramids, that is, of the paired structures located at the medial aspect of the ventral medulla that flank the anterior median fissure.
http://purl.obolibrary.org/obo/HP_0034974	Bathrocephaly	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		A deformity of the posterior skull with bulging of the midportion of the occipital bone that is often associated with a benign variant of the mendosal suture.
http://purl.obolibrary.org/obo/HP_0034975	Occipital horn	http://purl.obolibrary.org/obo/HP_0012294	Abnormal occipital bone morphology		Downward pointing exostoses of the occipital bone situated in the tendinous insertions of the sternocleidomastoid and trapezius muscles.
http://purl.obolibrary.org/obo/HP_0034976	Absent pituitary stalk	http://purl.obolibrary.org/obo/HP_0034977	Abnormal pituitary stalk morphology		A developmental defect characterized by failure to develop of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland.
http://purl.obolibrary.org/obo/HP_0034977	Abnormal pituitary stalk morphology	http://purl.obolibrary.org/obo/HP_0000864	Abnormality of the hypothalamus-pituitary axis		A structural anomaly of the pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland.
http://purl.obolibrary.org/obo/HP_0034978	Interrupted pituitary stalk	http://purl.obolibrary.org/obo/HP_0034977	Abnormal pituitary stalk morphology		A developmental defect characterized by a discontinuity of the pituitary stalk. The pituitary stalk, also known as the infundibulum or infundibular stalk, is the connection between the hypothalamus and the pituitary gland.
http://purl.obolibrary.org/obo/HP_0034979	Facial synkinesis	http://purl.obolibrary.org/obo/HP_0034980	Synkinesis		Unintentional movement in one area of the face produced during intentional movement of another area of the face.
http://purl.obolibrary.org/obo/HP_0034981	Exposure to birds	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of exposure to birds.
http://purl.obolibrary.org/obo/HP_0034982	Perianal anesthesia	http://purl.obolibrary.org/obo/HP_0033748	Hypoesthesia		Loss of sensation to the area of buttocks, perianal space and thighs.
http://purl.obolibrary.org/obo/HP_0034983	Failure of phenylephrine to induce blanching of eye redness	http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye		Instillation of 2.5% phenylephrine drops into the eye does not induce blanching of eye redness. Failure to blanch suggests redness caused by scleral vessel engorgement (e.g., scleritis) or extravascular cause (e.g., hemorrhage), not episcleritis or conjunctivitis.
http://purl.obolibrary.org/obo/HP_0034984	Fetal alcohol exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to ethanol (alcohol).
http://purl.obolibrary.org/obo/HP_0034985	Reduced cellular cobalamin uptake	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		Diminished ability of cells to transport cobalamine from the extracellular space to the cytoplasm.
http://purl.obolibrary.org/obo/HP_0034986	Focal necrotic brainstem lesion	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the brainstem.
http://purl.obolibrary.org/obo/HP_0034987	Focal necrotic optic nerve lesion	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the optic nerve.
http://purl.obolibrary.org/obo/HP_0034988	Focal necrotic thalamus lesion	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		A localized area of cell death, often accompanied by infiltration of inflammatory cells, in the thalamus.
http://purl.obolibrary.org/obo/HP_0034989	Interstitial dermal edema	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Accumulation of fluid in the interstitial spaces of the skin. This finding can be appreciated my microscopic examination of a skin biopsy.
http://purl.obolibrary.org/obo/HP_0034991	Shoulder external rotation contracture	http://purl.obolibrary.org/obo/HP_0034665	Shoulder contracture		A type of shoulder contracture characterized by decreased internal rotation of shoulder, that is, by a chronic reduction in active and passive ability to internally rotate the humerus at the shoulder joint (if the arm is flexed at the elbow, Internal rotation of the shoulder rotates the forearm towards the center of the body).
http://purl.obolibrary.org/obo/HP_0034992	Thumb adduction contracture	http://purl.obolibrary.org/obo/HP_0009600	Thumb contracture		A type of thumb contracture characterized by a chronic reduction in active and passive ability of the metacarpal-phalangeal and/or interphalangeal joints of the thumb to bring from medial side to neutral position, where the neutral position for the thumb is when the distal and proximal segments of the thumb joint are in linear alignment.
http://purl.obolibrary.org/obo/HP_0034993	Hip internal rotation contracture	http://purl.obolibrary.org/obo/HP_0003273	Hip contracture		The inability to rotate the proximal or upper limb segment laterally past anatomic neutral moving away from the midline, when viewed from anteriorly. Anatomic neutral position is defined as the trans-epicondylar axis of the distal humerus (for upper extremity) or femur (for lower extremity) is parallel to the sagittal plane of the body. This type of contracture is characterized by a turning of the knee from a neutral position to one facing more the midline, where the neutral position for the hip is with knee pointing directly anteriorly (less than or equal to 45 degrees).
http://purl.obolibrary.org/obo/HP_0034995	Reduced tissue fructose-1,6-bisphosphatase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of fructose-1,6-bisphosphatase (EC 3.1.3.11) below the lower limit of normal. The activity can be measured in multiple tissues including liver and leukocytes.
http://purl.obolibrary.org/obo/HP_0034996	Reduced hepatic carbamoylphosphate synthetase 1 activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of carbamoylphosphate synthetase 1 in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034997	Reduced intraepidermal small nerve fiber density	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Reduced number of small nerve fibers in the skin.
http://purl.obolibrary.org/obo/HP_0034998	Femoral artery duplication	http://purl.obolibrary.org/obo/HP_0035012	Abnormal femoral artery morphology		A developmental defect characterized by the presence of a supernumerary femoral artery.
http://purl.obolibrary.org/obo/HP_0034999	Intracellular accumulation of collagen VII	http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology		Collagen VII is the major molecular constituent of anchoring fibrils in the skin. Collagen VII is synthesized as three identical pro-alpha1(VII) polypeptide chains, which are hydroxylated and glycosylated in a coordinated manner and then fold into triple-helical procollagen VII in the endoplasmic reticulum (ER). Mature collagen VII undergoes a multistep fibril polymerization process to form the anchoring fibrils. Mutant pro-alpha1(VII) polypeptide chains or procollagen VII molecules do not pass the ER quality control and are retained in the ER or designated for ubiquitin-proteasome degradation resulting in reduced amounts of collagen VII in the skin.
http://purl.obolibrary.org/obo/HP_0035000	Reduced reticular lamina anchoring fibril density	http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology		Diminished amount of the anchoring fibrils in the basement membrane zone that normally attach the epithelium to the basement membrane.
http://purl.obolibrary.org/obo/HP_0035001	Reduced lamina lucida anchoring filament density	http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology		Diminished amount of the anchoring filaments that normally bridge the lamina lucida and insert into the lamina densa in the cutaneous basement membrane zone.
http://purl.obolibrary.org/obo/HP_0035002	Reduced epidermal keratin 5 protein expression	http://purl.obolibrary.org/obo/HP_0035004	Reduced epidermal keratin protein expression		Amount of keratin 5 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy.
http://purl.obolibrary.org/obo/HP_0035003	Reduced epidermal keratin 14 protein expression	http://purl.obolibrary.org/obo/HP_0035004	Reduced epidermal keratin protein expression		Amount of keratin 14 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy.
http://purl.obolibrary.org/obo/HP_0035004	Reduced epidermal keratin protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		Amount of one or more keratins in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy.
http://purl.obolibrary.org/obo/HP_0035005	Reduced hepatic alanine-glyoxylate aminotransferase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of alanine-glyoxylate aminotransferase in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0035006	Hepatic sinusoidal dilatation	http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology		Presence of an increased amount of blood in the hepatic capillaries.
http://purl.obolibrary.org/obo/HP_0035007	Thin spermatozoon midpiece	http://purl.obolibrary.org/obo/HP_0012867	Abnormal sperm mid-piece morphology		The cross-sectional size (diameter) of the midpiece of the spermatozoon is below the lower limit of normal. This term applies if the proportion of spermatozoa with this defect is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035008	Thick spermatozoon midpiece insertion	http://purl.obolibrary.org/obo/HP_0012867	Abnormal sperm mid-piece morphology		Increased width of the midpiece of the spermatozoon. The midpiece is the structure that is located between the head and the flagella (tail) of the spermatozoon. This term applies if the width of the midpiece increases progressively from the flagella to the head and if the proportion of individual spermatozoa with this anomaly is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035009	Shoulder adduction contracture	http://purl.obolibrary.org/obo/HP_0034665	Shoulder contracture		A type of shoulder contracture characterized by a chronic reduction in the active and passive ability to abduct the shoulder. This results in the shoulders being closer to midline. The affected individual is not able to position the shoulders away from the body.
http://purl.obolibrary.org/obo/HP_0035010	Occupational exposure history	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		Exposure to a substance that results from the performance of an employee's duties.
http://purl.obolibrary.org/obo/HP_0035011	Occupational silver exposure	http://purl.obolibrary.org/obo/HP_0035010	Occupational exposure history		A history of exposure to silver that has occurred in relation to performance of job duties.
http://purl.obolibrary.org/obo/HP_0035012	Abnormal femoral artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any structural abnormality of the femoral artey, a large blood vessel that provides oxygenated blood to lower extremity structures and in part to the lower anterior abdominal wall.
http://purl.obolibrary.org/obo/HP_0035014	Extrahepatic bile duct fibrosis	http://purl.obolibrary.org/obo/HP_0035013	Abnormal extrahepatic bile duct morphology		Accumulation of fibrous connective tissue (collagen) in the extrahepatic bile ducts.
http://purl.obolibrary.org/obo/UBERON_8600017	bronchopulmonary segment	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface.
http://purl.obolibrary.org/obo/HP_0040425	Abnormal urinary hypoxanthine level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		The concentration of hypoxanthine in the urine, normalized for urine concentration, is outside of normal limits.
http://purl.obolibrary.org/obo/HP_0430046	Small joint hypermobility	http://purl.obolibrary.org/obo/HP_0001382	Joint hypermobility		The capability that a small joint (or a group of joints) has to move, passively and/or actively, beyond normal limits along physiological axes. Small joints include metacarpophalangeal joints, proximal interphalangeal joints, 
second to fifth metatarsophalangeal joints, and wrists.
http://purl.obolibrary.org/obo/HP_5201016	Submucous cleft palate	http://purl.obolibrary.org/obo/HP_0000175	Cleft palate		A cleft of the muscular portion of the palate that is covered by mucous membrane.
http://purl.obolibrary.org/obo/HP_4000214	Diminished breath sounds	http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound		A reduction in the intensity of the breath sound as ascertained by auscultation of the lung.
http://purl.obolibrary.org/obo/HP_6000000	Left-right disorientation	http://purl.obolibrary.org/obo/HP_5200423	Abnormal experience of reality		A tendency to mix up left and right in one's own body space, typically elicited by asking a person to perform a two-stage command involving specified lateralized anatomy.
http://purl.obolibrary.org/obo/HP_6000001	Elevated circulating DNAJB9 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of DNAJB9 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000002	Olecranon fracture	http://purl.obolibrary.org/obo/HP_0041219	Elbow fracture		A partial or complete break in the olecranon,which is the proximal articular portion of the ulna and makes up part of the elbow.
http://purl.obolibrary.org/obo/HP_6000003	History of mastectomy	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		Past medical history of surgical breast removal.
http://purl.obolibrary.org/obo/HP_6000004	Lymphangiosarcoma	http://purl.obolibrary.org/obo/HP_0012797	Lymphatic vessel neoplasm		A malignant neoplasm arising from the endothelial cells of the lymphatic vessels.
http://purl.obolibrary.org/obo/HP_6000005	Exposure to inhaled lipids	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		Aspiration or inhalation of lipid-containing products.
http://purl.obolibrary.org/obo/HP_6000006	Holster sign	http://purl.obolibrary.org/obo/HP_0001029	Poikiloderma		Symmetric poikiloderma of hips and lateral thighs below the greater trochanter.
http://purl.obolibrary.org/obo/HP_6000007	Salivary basal cell adenoma	http://purl.obolibrary.org/obo/HP_0100684	Salivary gland neoplasm		A rare neoplasm consisting of a monomorphic population of basaloid epithelial cells, and it accounts for approximately 1-2% of all salivary gland tumors.
http://purl.obolibrary.org/obo/HP_6000008	Hemidiaphragm elevation	http://purl.obolibrary.org/obo/HP_0040045	Abnormal hemidiaphragm morphology		Elevated Hemidiaphragm is a condition where one portion of the diaphragm is higher than the other. Elevated hemidiaphragm occurs when one side of the diaphragm becomes weak from muscular disease or loss of innervation due to phrenic nerve injury.
http://purl.obolibrary.org/obo/HP_6000009	Cerebriform connective tissue nevus	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		The cerebriform connective tissue nevus (CCTN) is one of the most characteristic skin findings. It commonly occurs on the soles of the feet, and frequently causes problems because of pain, pruritus, infection, bleeding,exudation, odor, and walking impairment.
http://purl.obolibrary.org/obo/HP_6000010	Linear Hyperpigmentation along Blaschko's lines	http://purl.obolibrary.org/obo/HP_0007546	Linear hyperpigmentation		Linear streaks and swirls of macular hyperpigmentation along the lines of Blaschko.
http://purl.obolibrary.org/obo/HP_6000011	Guilt	http://purl.obolibrary.org/obo/HP_0031467	Dysregulated negative emotional state		The experience of remorse, self-reproach, or perceived culpability for a real or perceived unfavorable outcome. Guilt may be proportionate to the context or disproportionate, and it may occur in the absence of an identifiable act, event, or offense. It reflects the interplay of cognitive processes, such as judgments about responsibility, and emotional responses, which can lead to persistent rumination or preoccupation. Guilt may extend to situations outside the individual's control and, in some cases, be accompanied by inaccurate or exaggerated beliefs about one's role in an outcome.
http://purl.obolibrary.org/obo/HP_6000012	Mediastinal shift	http://purl.obolibrary.org/obo/HP_0045026	Abnormal mediastinum morphology		A deviation of the mediastinum from its normal position in the midline of the thoracic cavity. The mediastinum is a compartment of the thoracic cavity that contains the heart and its blood vessels, the esophagus, trachea, thymus, as well as nerves and lymph nodes.
http://purl.obolibrary.org/obo/HP_6000013	Bendopnea	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		Dyspnea as a result of bending forward while not holding one's breath; dyspnea or shortness of breath onset within 30 seconds of bending forward.
http://purl.obolibrary.org/obo/HP_6000014	Pain worse when lying flat	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Refers to pain that is worse when the affected individual lies down (flat).
http://purl.obolibrary.org/obo/HP_6000015	Tympanic membrane hypermobility	http://purl.obolibrary.org/obo/HP_0031704	Abnormal ear physiology		Abnormally increased ability to move of the tympanic membrane.
http://purl.obolibrary.org/obo/HP_6000016	Elevated circulating vitamin B12 concentration	http://purl.obolibrary.org/obo/HP_0004341	Abnormal vitamin B12 concentration		Concentration of vitamin B12 in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000017	Elevated circulating sFASL concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of sFASL (soluble FASL, soluble FAS-ligand) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000018	Internal anal sphincter achalasia	http://purl.obolibrary.org/obo/HP_0034916	Abnormal anus physiology		A disorder of the internal anal sphincter (IAS) in which the IAS fails to relax that manifests clinically as intractable constipation.
http://purl.obolibrary.org/obo/HP_6000019	Anthracycline exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of treatment with an anthracycline chemotherapy agent.
http://purl.obolibrary.org/obo/HP_6000020	Binge drinking	http://purl.obolibrary.org/obo/HP_0430037	Abnormal alcohol consumption		A pattern of episodic heavy alcohol use characterized by the consumption of a high number of drinks per occasion.
http://purl.obolibrary.org/obo/HP_6000021	Decreased circulating thrombopoietin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of thrombopoietin in the blood circulation below the lower limit of normal. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney that stimulates the production and differentiation of megakaryocytes.
http://purl.obolibrary.org/obo/HP_6000022	Collagenoma	http://purl.obolibrary.org/obo/HP_0100898	Connective tissue nevi		A rare hamartomatous malformation characterized by the predominant proliferation of normal collagen fibers and normal, decreased, or increased elastic fibers. Collagenomas may be solitary or multiple, sporadic, acquired or inherited.
http://purl.obolibrary.org/obo/HP_6000023	Lack of sufficient daily physical activity	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Physical activity levels less than those required for optimal health and prevention of premature death.
http://purl.obolibrary.org/obo/HP_6000024	Synesthesia	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		A phenomenon whereby stimulation of one sensory or cognitive pathway leads to automatic, involuntary experiences in a second sensory or cognitive pathway. For instance, people with synaesthesia may experience unusual colors, tastes, and other sensations when engaged in everyday activities like reading or listening to music.
http://purl.obolibrary.org/obo/HP_6000025	Dark cerumen	http://purl.obolibrary.org/obo/HP_0030790	Abnormal cerumen color		Abnormally dark color of cerumen (earwax), which is a waxy substance secreted in the ear canal that normally has a brown, orange, red, yellowish or gray.
http://purl.obolibrary.org/obo/HP_6000026	History of spicy food intake	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A history of high intake of spciy foods with ingrediaents such as capsaicin, pepper, chili, ginger, garlic, onion, fenugreek, and turmeric.
http://purl.obolibrary.org/obo/HP_6000027	Oil-drop brown pigmentation of the corneal limbus	http://purl.obolibrary.org/obo/HP_0007832	Pigmentation of the sclera		Brown pigment spots in the limbus (border between the cornea and the sclera).
http://purl.obolibrary.org/obo/HP_6000028	Hazardous alcohol use	http://purl.obolibrary.org/obo/HP_5200329	Problematic alcohol consumption		Hazardous drinking is defined as a quantity or pattern of alcohol consumption that places individuals at risk for adverse health events. This could include alcohol use despite potentially hazardous or risky consequences, such as operating heavy machinery or drunk driving.
http://purl.obolibrary.org/obo/HP_6000029	Social anxiety	http://purl.obolibrary.org/obo/HP_0000739	Anxiety		Excessive fear of embarrassment, humiliation, or rejection when exposed to possible negative evaluation by others when engaged in a public performance or social interaction.
http://purl.obolibrary.org/obo/HP_6000030	Placidity	http://purl.obolibrary.org/obo/HP_5200261	Abnormal demeanor		Flat affect and reduced response to emotional stimuli. Fear and anger responses that are normally present are blunted.
http://purl.obolibrary.org/obo/HP_6000031	Phaeohyphomycosis	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Phaeohyphomycosis refers to infections due to a large group of heterogenous organisms called dematiaceous or melanized fungi. These fungi are distinguished by the predominance of melanin in their cell walls, which likely acts as a virulence factor. Virtually, everyone is exposed to dematiaceous fungi through inhalation, as they are ubiquitous in the environment, although the development of infection is extremely uncommon.
http://purl.obolibrary.org/obo/HP_6000032	Autophony	http://purl.obolibrary.org/obo/HP_0000364	Hearing abnormality		Hearing one's own voice resonating loudly in the ear.
http://purl.obolibrary.org/obo/HP_6000033	High altitude exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of being at high altitude in situations such hiking, mountain climbing, travel to mountains, or air travel.
http://purl.obolibrary.org/obo/HP_6000034	History of recent hospitalization	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A past medical history of recently being hospitalized.
http://purl.obolibrary.org/obo/HP_6000035	Palpitations terminated by Valsava maneuver	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Cessation of palpitations can be induced by Valsava maneuver.
http://purl.obolibrary.org/obo/HP_6000036	Long telomere length	http://purl.obolibrary.org/obo/HP_0031412	Abnormal telomere morphology		Abnormally long telomeres in somatic cells.
http://purl.obolibrary.org/obo/HP_6000037	Reduced circulating aromatic L-amino acid decarboxylase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of aromatic L-amino acid decarboxylase (also known as DOPA decarboxylase, tryptophan decarboxylase, and 5-hydroxytryptophan decarboxylase) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000038	Subclavian artery stenosis	http://purl.obolibrary.org/obo/HP_0031251	Abnormal subclavian artery morphology		Abnormal narrowing of the subclavian artery.
http://purl.obolibrary.org/obo/HP_6000039	Pulsatile liver	http://purl.obolibrary.org/obo/HP_0031865	Abnormal liver physiology		Cardiac synchronous pulsation on palpation.
http://purl.obolibrary.org/obo/HP_6000040	Neuropathic pain	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its structure and function so that pain occurs spontaneously and responses to noxious and innocuous stimuli are pathologically amplified.
http://purl.obolibrary.org/obo/HP_6000041	Repeated cold water exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of repeated exposure to cold water, as may result, for instance, from surfing, diving, kayaking, or swimming.
http://purl.obolibrary.org/obo/HP_6000042	Tinnitus exacerbated by swallowing	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Tinnitus (sound heard by a subjhect when no corresponding external sound is present) that is made worse by swallowing.
http://purl.obolibrary.org/obo/HP_6000043	Rhythmic movements of the tympanic membrane	http://purl.obolibrary.org/obo/HP_0031704	Abnormal ear physiology		Regularly occurring motion of the tympanic membrane (eardrum), which is located between the inner and middle ear. This can be a manifestation of tensor tympani myoclonus, which can also be ascertained as sawtooth patterns on long-term tympanometry.
http://purl.obolibrary.org/obo/HP_6000044	Elongated temporal styloid process	http://purl.obolibrary.org/obo/HP_0009911	Abnormal temporal bone morphology		The length of the temporal styloid process is above the upper limit of normal. The styloid process is a cylindrical, slender, needle-like projection of varying lengths averaging 2 to 3 cm. The styloid process projects from the inferior part of the petrous temporal bone and offers attachment to the stylohyoid ligament and the stylohyoid, stylopharyngeus, and styloglossus muscles.
http://purl.obolibrary.org/obo/HP_6000045	Ameliorated by nitroglycerin	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with nitroglycerin.
http://purl.obolibrary.org/obo/HP_6000046	Pulsus paradoxus	http://purl.obolibrary.org/obo/HP_0032552	Abnormal pulse		Pulsus paradoxus refers to a systolic pressure drop greater than 10mmHg during inspiration.
http://purl.obolibrary.org/obo/HP_6000047	Chest pain triggered by palpation	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Chest pain can be induced by palpation of the chest, which may be an indication of costochondritis.
http://purl.obolibrary.org/obo/HP_6000048	Chest pain described as pressure	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Discomfort in the chest described as pressure, heaviness, or tightness.
http://purl.obolibrary.org/obo/HP_6000049	Chest pain described as ripping or tearing	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Chest pain described as a tearing or ripping sensation.
http://purl.obolibrary.org/obo/HP_6000050	Ameliorated by flexion	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by bending (flexing) a joint.
http://purl.obolibrary.org/obo/HP_6000051	Located on the chest	http://purl.obolibrary.org/obo/HP_6000425	Truncal location		Applies to a finding that is situated or occurring around the thorax (chest).
http://purl.obolibrary.org/obo/HP_6000052	Localized to the penis	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to a finding that is situated or occurring in or on the penis.
http://purl.obolibrary.org/obo/HP_6000053	Snowstorm pattern of uterus on ultrasound	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		A sonographic snowstorm pattern of the uterus that results from the presence of a complex vesicular intrauterine mass containing many grape-like cysts.
http://purl.obolibrary.org/obo/HP_6000054	Multiparity	http://purl.obolibrary.org/obo/HP_0032467	Past obstetric history		History of multiple previous births.
http://purl.obolibrary.org/obo/HP_6000055	Exposure to aquatic animals	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of exposure to aquatic animals.
http://purl.obolibrary.org/obo/HP_6000056	Superficial blush-like subcutaneous fatty lesions	http://purl.obolibrary.org/obo/HP_0001001	Abnormality of subcutaneous fat tissue		Multiple, oblong, fatty lesions in the superficial subcutaneous fatty tissue. They are mostly under 2 cm in long axis diameter. They demonstrate nodular (blush-like) increased fluid signal at unenhanced MRI and are markedly hyperechoic at ultrasound.
http://purl.obolibrary.org/obo/HP_6000057	Dermal multinucleated giant cells	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Presence of giant cells in the dermis. Giant cells are formed by fusion of various cells such as macrophage, epithelioid cells, monocytes, etc., These are multi-nucleated, large in size, and generally present at the site of chronic inflammation and other granulomatous conditions.
http://purl.obolibrary.org/obo/HP_6000058	Exacerbation of eyelid lesion by crying	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applies to an eyelid lesion such as hemangiomas or varices that swells upon crying.
http://purl.obolibrary.org/obo/HP_6000059	Localized to upper eyelid	http://purl.obolibrary.org/obo/HP_6001266	Localized to eyelid		Applies to an abnormality that is situated in the upper eyelid.
http://purl.obolibrary.org/obo/HP_6000060	Aerophagia	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Repetitive air swallowing and belching and that may result in abdominal distention.
http://purl.obolibrary.org/obo/HP_6000061	Vaginal passage of hydatidiform mole tissue	http://purl.obolibrary.org/obo/HP_0034268	Abnormal vaginal physiology		Passage from the vagina of hyatidiform tissue, appearing as clusters of vesicles (similar to small grapes) developed from the transformation of chorionic villi. This is a manifestation of a molar pregnancy (hyatidiform mole).
http://purl.obolibrary.org/obo/HP_6000062	Abnormal nipple discharge	http://purl.obolibrary.org/obo/HP_0031094	Abnormal breast physiology		Abnormal fluid that seeps out of the nipple of the breast. Nipple discharge is categozied as lactational, physiologic, or pathologic.
http://purl.obolibrary.org/obo/HP_6000063	Hepatolithiasis	http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology		The presence of gallstones within the intrahepatic bile ducts proximal to the right and left hepatic ducts.
http://purl.obolibrary.org/obo/HP_6000064	Excessive eructation	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Abnormally frequent belching (expelling gas noisily from the stomach through the mouth).
http://purl.obolibrary.org/obo/HP_6000065	Esophageal fibrosis	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Fibrosis located in the subepithelial portion of the esophagus. Fibrosisis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen.
http://purl.obolibrary.org/obo/HP_6000066	Triggered by extension of leg	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		This term refers to pain that is triggered by extending (straightening) the leg.
http://purl.obolibrary.org/obo/HP_6000067	Increased myocardial pyrophosphate uptake	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Amount of pyrophosphate uptake by the myocardium as demonstrated by by technetium pyrophosphate (99mTc-PYP) scintigraphy above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000068	Ameliorated by nerve block	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Refers to a sign or symptom that is improved or made more bearable by anesthetic block of a nerve.
http://purl.obolibrary.org/obo/HP_6000069	Brief tear break-up time	http://purl.obolibrary.org/obo/HP_0000632	Lacrimation abnormality		Tear film break up time (number of seconds that elapse between the last blink and the appearance of the first dry spot in the tear film) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000070	Cutaneous granuloma	http://purl.obolibrary.org/obo/HP_0032252	Granuloma		A granuloma localized to the skin, that is, a chronic inflammatory manifestation with localized aggregation of histiocytes with or without other inflammatory cells (such as plasma cells, eosinophils, or neutrophils), with or without necrosis, with or without vasculitis, with or without calcification, and with or without foreign bodies. Granulomas may be due to infection or chronic inflammatory disease or reactions to foreign material.
http://purl.obolibrary.org/obo/HP_6000071	Heterotopic dermal ossification	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Formation of abnormal, extraskeletal bony tissue in the dermis (i.e., the layer of skin that lies beneath the epidermis and above the subcutaneous layer).
http://purl.obolibrary.org/obo/HP_6000072	Thinning of outer muscular layer of small bowel	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		The depth of the outer muscular layer of the small bowel is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000073	Renal lymphangiectasia	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		A developmental anomaly of renal lymphatics that results from a failure of the lymphatics to make communication with the rest of the lymph trunks. The abnormal lymphatics thus dilate and form cystic spaces at the renal sinus and in the perinephric space.
http://purl.obolibrary.org/obo/HP_6000074	Pharyngeal myxoma	http://purl.obolibrary.org/obo/HP_0100638	Neoplasm of the pharynx		A myxoma (benign, locally infiltrative neoplasms arising from mesenchymal origin) localized to the pharynx.
http://purl.obolibrary.org/obo/HP_6000075	Subcutaneous arteriolar thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		Fibrin thrombi inside subcutaneous arterioles.
http://purl.obolibrary.org/obo/HP_6000076	Renal vasculitis	http://purl.obolibrary.org/obo/HP_0033835	Abnormal renal vascular morphology		Vasculitis (inflammation of blood vessels) in the kidney. Renal vasculitis can be observed with numerous disorders and presents clinically as rapidly progressive glomerulonephritis (RPGN) which is characterized by acute kidney injury (AKI), haematuria and proteinuria. Histological examination of the kidney reveals severe inflammation in the form of crescent formation, glomerular necrosis and vasculitis of small and medium sized vessels within the kidney.
http://purl.obolibrary.org/obo/HP_6000077	Pancreatic islet beta cell iron deposition	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Accumulation of abnormally high amounts of iron in beta cells of the pancreas.
http://purl.obolibrary.org/obo/HP_6000078	Nasal hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A hamartoma (tissue malformation consisting of an abnormal mixture of constitutive components) originating in the nose.
http://purl.obolibrary.org/obo/HP_6000079	Metachromatic intraneuronal lipid deposits	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		A type of metachromasia localized to a peripheral nerve. Metachromasia may be defined as the staining of tissue or tissue components such that the color of the tissue-bound dye complex differs significantly from the color of the original dye complex to give a marked contrast in color. For instance in metachromatic leukodystrophy, bloated Schwann cells, containing granularmetachromatic storage material May display a characteristic yellow green dichroism under crossed polarised light.
http://purl.obolibrary.org/obo/HP_6000080	Reduced phosphoserine phosphatase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of phosphoserine phosphatase below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000081	Reduced alpha-aminoadipic semialdehyde synthase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of alpha-aminoadipic semialdehyde synthase below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000082	Reduced hepatic beta-ureidopropionase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of beta-ureidopropionase in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000083	Reduced hepatic dihydropyrimidinase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of dihydropyrimidinase in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000084	Sunken fontanelle	http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology		Fontanelle that is more deeply set than normal. Fontanelles are normally relatively firm and curve only slightly inward. A sunken fontanelle can be a sign of dehydration or marasmus.
http://purl.obolibrary.org/obo/HP_6000085	Angulation of penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Formation of an angle (tilt) along the shaft of the penis.
http://purl.obolibrary.org/obo/HP_6000086	History of urethral procedure or catheterization	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		A past medical history of a procedure or catheterization involving the urethra.
http://purl.obolibrary.org/obo/HP_6000087	Penile swelling	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Abormal enlargement of the penis owing to accumulation of fluid.
http://purl.obolibrary.org/obo/HP_6000088	Reduced muscle alpha-1,4-glucosidase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the enzyme alpha-1,4-glucosidase activity in muscle tissue is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000089	Brown tumor	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		A brown tumor is a bone lesion that results from bony resorption by excess osteoclastic activity, and replacement by fibrous tissue and giant cells. Brown tumor is an uncommon pathognomonic sign of hyperparathyroidism.
http://purl.obolibrary.org/obo/HP_6000090	Dermal flame figures	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Flame-figures are composed of a central part consisting of collagen fibers and eosinophilic granules, surrounded by a histiocytic and eosinophilic infiltrate. Subsequently, eosinophils tend to disappear and are replaced by phagocytic granulomas, consisting of histiocytes and sometimes giant cells, around the flame figures.
http://purl.obolibrary.org/obo/HP_6000091	Postpartum exacerbation	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is present during pregnancy and becomes worse following birth.
http://purl.obolibrary.org/obo/HP_6000092	Retinoid exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken retinoids.
http://purl.obolibrary.org/obo/HP_6000093	Propylthiouracil exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with propylthiouracil.
http://purl.obolibrary.org/obo/HP_6000094	History of outdoor activities	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		History of spending a substantial amount of time outdoors with occupation or hobbies related to the outdoors, including hunting, gardening, farming, agriculture, horticulture, miners, working in wet fields.
http://purl.obolibrary.org/obo/HP_6000095	Draining sinus tract in skin	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A sinus tract is an abnormal channel that originates from the skin or a mucous surface to a deep-seated focus of suppuration.
http://purl.obolibrary.org/obo/HP_6000096	Corneal transplant history	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		Past medical history of surgical replacement of the cornea with corneal tissue from a donor.
http://purl.obolibrary.org/obo/HP_6000097	Spontaneous lens capsule rupture	http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology		Breakage of the capsule of the lens. This is most often observed as a complication of lens surgery, but this term refers to lens capsule rupture not related to surgery or major trauma.
http://purl.obolibrary.org/obo/HP_6000098	Contact lens wearer	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A past medical history of wearing contact lenses.
http://purl.obolibrary.org/obo/HP_6000099	Airway mucosal thickening	http://purl.obolibrary.org/obo/HP_0012253	Abnormal respiratory epithelium morphology		Increase in thickness of the mucosa of the airways above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000100	Hyperpolarized transepithelial nasal potential difference	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Increased (more negative) voltage across the nasal epithelium.
http://purl.obolibrary.org/obo/HP_6000101	Corneopalpebral synechiae	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		An adhesion between the conjunctiva of the eyelid and the cornea.
http://purl.obolibrary.org/obo/HP_6000102	Breast intraductal papilloma	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		Intraductal papilloma is a benign tumor found within breast ducts. The abnormal proliferation of ductal epithelial cells causes growth. A solitary intraductal papilloma is usually found centrally posterior to the nipple affecting the central duct. Multiple intraductal papillomas are located peripherally, found in any breast quadrant affecting the peripheral ducts.
http://purl.obolibrary.org/obo/HP_6000103	Precipitous labor	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Precipitous labor is extremely rapid labor and delivery, usually defined as expulsion of the fetus within less than 3 hours of commencement of regular contractions.
http://purl.obolibrary.org/obo/HP_6000104	Twin pregnancy	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Maternal history of a pregnancy with two fetuses in the uterus.
http://purl.obolibrary.org/obo/HP_6000105	Vaginal mass	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		A swelling or enlargement localized to the vagina. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000106	Costovertebral angle tenderness	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain that is elicited by palpation of the region inside of the costovertebral angle, which is formed by the 12th rib and the spine.
http://purl.obolibrary.org/obo/HP_6000107	Cervical motion tenderness	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain that is elicited by moving the uterine cervix. This finding can be ascertained by pelvic exam. Cervical motion tenderness is a gynecological exam finding that could be indicative of peritoneal infection.
http://purl.obolibrary.org/obo/HP_6000108	Abnormal urethral discharge	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		Fluid that originates from the urethra that is not urine, pre-ejaculate or semen.
http://purl.obolibrary.org/obo/HP_6000109	Supernumerary finger flexion crease	http://purl.obolibrary.org/obo/HP_0006143	Abnormal finger flexion crease		The presence of an extra digital crease in and individual with normal joint anatomy.
http://purl.obolibrary.org/obo/HP_6000110	Large joint predominance	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Refers to a phenotypic abnormality that mainly affect large joints.
http://purl.obolibrary.org/obo/HP_6000111	Monoarticular	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Refers to a phenotypic abnormality that affects a single joint.
http://purl.obolibrary.org/obo/HP_6000112	Hockey-stick palmar crease	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		An abnormality of the upper palmar crease whereby the crease widens and ends between the second and third fingers and is said to resemble a hockey stick.
http://purl.obolibrary.org/obo/HP_6000113	Elevated urinary succinyladenosine level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		The amount of succinyladenosine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000114	Elevated urinary 5-hydroxymethyluracil level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		The amount of 5-hydroxymethyluracil in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000115	Decreased urine creatinine level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The amount of creatinine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000116	Elevated urinary deoxyuridine level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		The amount of deoxyuridine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000118	Elevated urinary dihydrouracil level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		The amount of dihydrouracil in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000119	Elevated urinary dihydrothymine level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		The amount of dihydrothymine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000120	Elevated urinary sulfatide level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The amount of sulfatides in the urine, normalized for urine concentration, is above the upper limit of normal. Sulfatides are derived from GalCer via esterification of a sulfate group to 3-hydroxyl of the galactose moiety.
http://purl.obolibrary.org/obo/HP_6000121	Elevated urinary xanthurenic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of xanthurenic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000122	Increased urinary N-acetylglucosamine-rich oligosaccharide level	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		Presence of N-acetylglucosamine-rich oligosaccharides in the urine.
http://purl.obolibrary.org/obo/HP_6000123	Elevated urinary 2'-deoxyadenosine level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		The amount of 2'-deoxyadenosine (dAdo) in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000124	Positive 2,4-dinitrophenylhydrazine urine test	http://purl.obolibrary.org/obo/HP_0033456	Elevated urine keto acid level		Positive (abnormal) result of the 2,4-dinitrophenylhydrazine urine test, which indicates the presence of alpha-ketoacids in the urine.
http://purl.obolibrary.org/obo/HP_6000125	Elevated urinary dolichol level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		The amount of dolichol in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000126	Decreased urinary bile acid level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		The amount of bile acids in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000127	Elevated urinary creatine/creatinine ratio	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The ratio of creatine to creatinine concentration in the urine is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000128	Elevated urinary thymidine level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		The amount of thymidine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000129	Elevated urinary glutarylglycine level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of glutarylglycine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000130	Elevated urinary indican level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Detection of indican in the urine. Urinary indican concentration may be elevated in small bowel bacterial overgrowth. Indican is produced by bacterial deconjugation of dietary tryptophan to indole which is absorbed at all levels of the intestine, but principally from the small bowel.
http://purl.obolibrary.org/obo/HP_6000131	Dacrolith	http://purl.obolibrary.org/obo/HP_0000614	Abnormal nasolacrimal system morphology		Dacryolith is a concretion (accumulation of sediment) within the nasolacrimal system.
http://purl.obolibrary.org/obo/HP_6000132	Reduced erythrocyte gamma-glutamyl cysteine synthetase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity of gamma-glutamylcysteine synthetase (EC 6.3.2.2) in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000133	Decreased erythrocyte nicotinamide adenine dinucleotide-cytochrome b5 reductase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		The activity of nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase in erythrocytes (red blood cells) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000134	Reduced alpha-methylacyl-CoA racemase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of alpha-methylacyl-CoA racemase (AMACR; EC 5.1.99.4) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000135	Low semen volume	http://purl.obolibrary.org/obo/HP_0012874	Abnormal male reproductive system physiology		Volume of semen in ejaculate below the lower limit of normal. This finding can be ascertained by semen analysis. Comment: Sperm are produced within the testis, in the process of spermatogenesis, then travel through the male reproductive tract (the seminiferous tubules, epididymis, vas deferens, prostate and urethra). As the sperm travel, seminal fluid is added from the seminal vesicles, prostate, testis and epididymis and periurethral glands. The function of the ejaculate is to transport sperm into the female genital tract and to provide a suitable environment for sperm survival during this transit.
http://purl.obolibrary.org/obo/HP_6000136	Elbow localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in (or predominant in) the elbow.
http://purl.obolibrary.org/obo/HP_6000137	Enlarged lunula	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Abnormal enlargement of the visible portion of the distal nail matrix that extends beyond the proximal nail fold, which is referred to as the lunula.
http://purl.obolibrary.org/obo/HP_6000138	Heel localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in (or predominant in) the heel.
http://purl.obolibrary.org/obo/HP_6000139	Splinter hemorrhages	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Thin, red to reddish-brown lines of blood (hemorrhages) under the nails. Splinter hemorrhages run vertically under the nails.
http://purl.obolibrary.org/obo/HP_6000140	Lateral thrust	http://purl.obolibrary.org/obo/HP_0034670	Abnormal knee physiology		Lateral thrust (LT) refers to an abnormal knee joint motion in the early stance phase where the knee joint center moves laterally. Also known as varus thrust, LR is defined as the dynamic worsening or abrupt onset of varus (bow-leg) alignment as the limb accepts weight (stance phase), with a return to less varus and more neutral alignment during lift-off and the non-weight-bearing (swing) phase of gait, varus thrust is a potent mechanical risk factor for medial knee osteoarthritis progression.
http://purl.obolibrary.org/obo/HP_6000141	Cerebral contusion	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		A contusion is a region of injured tissue in which blood capillaries have been ruptured without laceration (bruise). Brain contusions are bruises of the cortical surface that damage the surface from the outside inward, producing disruption of tissue and vessels. The term cerebral contusion describes the pathology of focal necrosis and hemorrhage, typically observed in older children, involving particularly cerebral cortex and subcortical white matter. Such lesions are usually found in coup and contrecoup, as well as inferior orbital, frontal, and temporal locations. Cerebral contusions cause permanent damage to tissues of the cerebrum. The etiology of cerebral contusion is trauma to the head.
http://purl.obolibrary.org/obo/HP_6000142	Fecolith	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		A mass of accumulated hardened fecal matter.
http://purl.obolibrary.org/obo/HP_6000143	Appendicitis	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		Appendicitis is an inflammation of the vermiform appendix, which is a hollow organ located at the tip of the cecum, usually in the right lower quadrant of the abdomen.
http://purl.obolibrary.org/obo/HP_6000144	Left ventricular aneurysm	http://purl.obolibrary.org/obo/HP_0001711	Abnormal left ventricle morphology		A severely scarred portion of infarcted ventricular myocardium that does not contract normally but instead bulges outward while the rest of the ventricle contracts during systole.
http://purl.obolibrary.org/obo/HP_6000145	Boot-shaped cardiac silhouette	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		An abnormal form of the heart seen upon chest radiography in which the heart displays an upturned apex and slight concave pulmonary artery segment. This configuration is said to resemble a boot.
http://purl.obolibrary.org/obo/HP_6000146	Hydrosalpinx	http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology		Hydrosalpinx is a distension or dilatation of the fallopian tube in the presence of a distal tubal occlusion.
http://purl.obolibrary.org/obo/HP_6000147	Elevated methylhex-dienedioic level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An increase in the level of 3-methylhex-2,4-dienedioic acid or 3-methylhex-3,4-dienedioic acid in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_6000148	Perihepatic enhancement	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Increased signal (contrast enhancement) surrounding the liver observed on computer tomography or magnetic resonance imaging following administration of contrast agents.
http://purl.obolibrary.org/obo/HP_6000149	Reduced in vitro contracture test threshold	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		The in vitro contracture test determines the sensitivity of freshly obtained skeletal muscle specimens to caffeine or halothane applied to a bathing solution. Muscles from persons susceptible to malignant hyperthermia have lower contracture thresholds for these agents than do normal muscle.
http://purl.obolibrary.org/obo/HP_6000150	Reduced F-wave amplitude	http://purl.obolibrary.org/obo/HP_0030179	Abnormal peripheral action potential amplitude		Reduced strength (amplitude) of the F-wave, which is an electrophysiological artifact produced by antidromic activation of motoneurons following distal electrical stimulation of motor nerve fibers.
http://purl.obolibrary.org/obo/HP_6000151	Enlarged peroxisomes	http://purl.obolibrary.org/obo/HP_0034552	Abnormal peroxisomal morphology		Abnormal increase in size of peroxisomes.
http://purl.obolibrary.org/obo/HP_6000152	Adrenocortical hyperplasia	http://purl.obolibrary.org/obo/HP_0000849	Adrenocortical abnormality		A non-malignant growth, or enlargement, of the adrenal glands, specifically the cortex, although the cortex cannot be definitively identified by conventional imaging. Adrenal cortical hyperplasia is defined radiologically as a non-malignant growth, or enlargement, of the adrenal glands.
http://purl.obolibrary.org/obo/HP_6000153	Lymphocytic infiltration of the parotid gland	http://purl.obolibrary.org/obo/HP_0000197	Abnormal parotid gland morphology		Accumulation of lymphocytes in the parotid gland. This feature is generally defined as a count of lymphocytes per area that is above normal limits on histopathological examination.
http://purl.obolibrary.org/obo/HP_6000154	Bone marrow granuloma	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		A granuloma (a focal aggregate of immune cells that forms in response to a persistent inflammatory stimulus) localiyed to the bone marrow. A granuloma characteristically demonstrates the compact organization of mature macrophages, which may or may not be associated with other inflammatory cell types.
http://purl.obolibrary.org/obo/HP_6000155	Neuronal intranuclear inclusion bodies	http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology		The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neurons.
http://purl.obolibrary.org/obo/HP_6000156	Pancreatic atrophy	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Wasting (shrinking) of the pancreas.
http://purl.obolibrary.org/obo/HP_6000157	Decreased pancreatic acinar cell density	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Number (count) of pancreatic acinar cells reduced below normal. This feature can be ascertained by pancreas biopsy.
http://purl.obolibrary.org/obo/HP_6000158	Unesterified cholesterol accumulation in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_0004356	Abnormality of lysosomal metabolism		An abnormal result of the filipin test. This test is based on the reaction of unesterified cholesterol with fluorescent antibiotic filipin giving a strongly fluorescent, stable cholesterol-filipin complex suitable for in situ detection. An abnormal test result is present if there is a perinuclear accumulation of staining in lysosomal storage organelles (LSOs).
http://purl.obolibrary.org/obo/HP_6000160	Splenic lipid-laden macrophage infiltration	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Accumulation of foamy cells (lipid-laden macrophages) in the parenchyma of the spleen.
http://purl.obolibrary.org/obo/HP_6000161	Reduced hepatic N-acetylglutamate synthase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Concentration or activity of N-acetylglutamate synthase in liver tissue below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025735	Abnormal third cranial nerve morphology	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		Any structural abnormality of the third (oculomotor) cranial nerve.
http://purl.obolibrary.org/obo/CL_1100001	secretory epithelial cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules.
http://purl.obolibrary.org/obo/CL_4033087	placental resident macrophage	http://purl.obolibrary.org/obo/CL_0000864	tissue-resident macrophage		A tissue-resident macrophage that is part of the placenta. This cell helps preventing immunological rejection of the fetus by modulating the immune environment. A placental resident macrophage has high plasticity to adapt to the changing needs of each phase of pregnancy.
http://purl.obolibrary.org/obo/CL_4033093	limbal epithelial stem cell of cornea	http://purl.obolibrary.org/obo/CL_0000036	epithelial fate stem cell		A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023).
http://purl.obolibrary.org/obo/CL_4042035	molecular layer interneuron	http://purl.obolibrary.org/obo/CL_4023057	cerebellar inhibitory GABAergic interneuron		A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties.
http://purl.obolibrary.org/obo/CL_4047017	transit amplifying cell of gut	http://purl.obolibrary.org/obo/CL_0009010	transit amplifying cell		A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells).
http://purl.obolibrary.org/obo/CL_4047023	intestinal lamina propria fibroblast	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin.
http://purl.obolibrary.org/obo/CL_4047025	type G cell of stomach	http://purl.obolibrary.org/obo/CL_1000222	stomach neuroendocrine cell		Any type G enteroendocrine cell that is part of some epithelium of stomach.
http://purl.obolibrary.org/obo/CL_4047034	smooth muscle cell of stomach	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell that is part of the muscularis externa of the stomach wall. It is characterized by its fusiform shape, involuntary control, and ability to generate slow, sustained contractions. This cell is organized in distinct layers and is essential for gastric motility and digestion.
http://purl.obolibrary.org/obo/CL_4047101	liver-resident natural killer cell	http://purl.obolibrary.org/obo/CL_0000623	natural killer cell		A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans.
http://purl.obolibrary.org/obo/CL_4052014	pancreatic islet capillary endothelial cell	http://purl.obolibrary.org/obo/CL_0002144	capillary endothelial cell		A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture.
http://purl.obolibrary.org/obo/CL_4052015	endocrine gland capillary endothelial cell	http://purl.obolibrary.org/obo/CL_0002144	capillary endothelial cell		Any capillary endothelial cell that is part of an endocrine gland.
http://purl.obolibrary.org/obo/CL_4052016	pituitary gland capillary endothelial cell	http://purl.obolibrary.org/obo/CL_2000044	brain microvascular endothelial cell		A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling.
http://purl.obolibrary.org/obo/CL_4052017	choroid plexus capillary endothelial cell	http://purl.obolibrary.org/obo/CL_2000044	brain microvascular endothelial cell		A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/CL_4052018	fallopian tube epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		Any epithelial cell that is part of the fallopian tube.
http://purl.obolibrary.org/obo/CL_4052022	fallopian tube smooth muscle cell	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell that is part of the fallopian tube. This cell is responsible for peristaltic contractions that facilitate gamete and embryo transport, fluid mixing, and embryo admission to the uterus.
http://purl.obolibrary.org/obo/CL_4052028	uterine natural killer cell	http://purl.obolibrary.org/obo/CL_0000623	natural killer cell		A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy.
http://purl.obolibrary.org/obo/CL_4052030	adventitial fibroblast	http://purl.obolibrary.org/obo/CL_0002503	adventitial cell		A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression
http://purl.obolibrary.org/obo/CL_0000941	thymic conventional dendritic cell	http://purl.obolibrary.org/obo/CL_0000990	conventional dendritic cell		A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative.
http://purl.obolibrary.org/obo/HP_0000002	Abnormality of body height	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		Deviation from the norm of height with respect to that which is expected according to age and gender norms.
http://purl.obolibrary.org/obo/HP_0000003	Multicystic kidney dysplasia	http://purl.obolibrary.org/obo/HP_0000107	Renal cyst		Multicystic dysplasia of the kidney is characterized by multiple cysts of varying size in the kidney and the absence of a normal pelvicaliceal system. The condition is associated with ureteral or ureteropelvic atresia, and the affected kidney is nonfunctional.
http://purl.obolibrary.org/obo/HP_0000005	Mode of inheritance	http://purl.obolibrary.org/obo/HP_0000001	All		The pattern in which a particular genetic trait or disorder is passed from one generation to the next.
http://purl.obolibrary.org/obo/HP_0000006	Autosomal dominant inheritance	http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance		A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
http://purl.obolibrary.org/obo/HP_0000007	Autosomal recessive inheritance	http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance		A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
http://purl.obolibrary.org/obo/HP_0000008	Abnormal morphology of female internal genitalia	http://purl.obolibrary.org/obo/HP_0010460	Abnormality of the female genitalia		An abnormality of the female internal genitalia.
http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder	http://purl.obolibrary.org/obo/HP_0000014	Abnormality of the bladder		Dysfunction of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0000010	Recurrent urinary tract infections	http://purl.obolibrary.org/obo/HP_5210135	Unusual genitourinary infection		Repeated infections of the urinary tract.
http://purl.obolibrary.org/obo/HP_0000011	Neurogenic bladder	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		A type of bladder dysfunction caused by neurologic damage. Neurogenic bladder can be flaccid or spastic. Common manifestatios of neurogenic bladder are overflow incontinence, frequency, urgency, urge incontinence, and retention.
http://purl.obolibrary.org/obo/HP_0000012	Urinary urgency	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Urge incontinence is the strong, sudden need to urinate.
http://purl.obolibrary.org/obo/HP_0000013	Hypoplasia of the uterus	http://purl.obolibrary.org/obo/HP_0008684	Aplasia/hypoplasia of the uterus		Underdevelopment of the uterus.
http://purl.obolibrary.org/obo/HP_0000014	Abnormality of the bladder	http://purl.obolibrary.org/obo/HP_0010936	Abnormality of the lower urinary tract		An abnormality of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0000015	Bladder diverticulum	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Diverticulum (sac or pouch) in the wall of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0000016	Urinary retention	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Inability to completely empty the urinary bladder during the process of urination.
http://purl.obolibrary.org/obo/HP_0000017	Nocturia	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Abnormally increased production of urine during the night leading to an unusually frequent need to urinate.
http://purl.obolibrary.org/obo/HP_0000019	Urinary hesitancy	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Difficulty in beginning the process of urination.
http://purl.obolibrary.org/obo/HP_0000020	Urinary incontinence	http://purl.obolibrary.org/obo/HP_0031064	Impaired continence		Loss of the ability to control the urinary bladder leading to involuntary urination.
http://purl.obolibrary.org/obo/HP_0000021	Megacystis	http://purl.obolibrary.org/obo/HP_0010955	Dilatation of the bladder		Dilatation of the bladder postnatally.
http://purl.obolibrary.org/obo/HP_0000022	Abnormal male internal genitalia morphology	http://purl.obolibrary.org/obo/HP_0010461	Abnormality of the male genitalia		An abnormality of the male internal genitalia.
http://purl.obolibrary.org/obo/HP_0000024	Prostatitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		The presence of inflammation of the prostate.
http://purl.obolibrary.org/obo/HP_0000026	Male hypogonadism	http://purl.obolibrary.org/obo/HP_0000135	Hypogonadism		Decreased functionality of the male gonad, i.e., of the testis, with reduced spermatogenesis or testosterone synthesis.
http://purl.obolibrary.org/obo/HP_0000027	Azoospermia	http://purl.obolibrary.org/obo/HP_0008669	Abnormal spermatogenesis		Absence of any measurable level of sperm,whereby spermatozoa cannot be observed even after centrifugation of the semen pellet.
http://purl.obolibrary.org/obo/HP_0000028	Cryptorchidism	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Testis in inguinal canal. That is, absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum.
http://purl.obolibrary.org/obo/HP_0000029	Testicular atrophy	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility.
http://purl.obolibrary.org/obo/HP_0000030	Testicular gonadoblastoma	http://purl.obolibrary.org/obo/HP_0010788	Testicular neoplasm		The presence of a gonadoblastoma of the testis.
http://purl.obolibrary.org/obo/HP_0000032	Abnormal male external genitalia morphology	http://purl.obolibrary.org/obo/HP_0010461	Abnormality of the male genitalia		Any structural abnormality of male external genitalia.
http://purl.obolibrary.org/obo/HP_0000033	Ambiguous genitalia, male	http://purl.obolibrary.org/obo/HP_0000062	Ambiguous genitalia		Ambiguous genitalia in an individual with XY genetic gender.
http://purl.obolibrary.org/obo/HP_0000034	Hydrocele testis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Accumulation of clear fluid in the between the layers of membrane (tunica vaginalis) surrounding the testis.
http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology	http://purl.obolibrary.org/obo/HP_0000032	Abnormal male external genitalia morphology		An anomaly of the testicle (the male gonad).
http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology	http://purl.obolibrary.org/obo/HP_0000032	Abnormal male external genitalia morphology		Abnormality of the male external sex organ.
http://purl.obolibrary.org/obo/HP_0000037	Male pseudohermaphroditism	http://purl.obolibrary.org/obo/HP_0000032	Abnormal male external genitalia morphology		Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In male pseudohermaphroditism, the genotype is male (XY) and the external genitalia are imcompletely virilized, ambiguous, or complete female. If gonads are present, they are testes.
http://purl.obolibrary.org/obo/HP_0000039	Epispadias	http://purl.obolibrary.org/obo/HP_0100627	Displacement of the urethral meatus		Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias.
http://purl.obolibrary.org/obo/HP_0000040	Long penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Penile length more than 2 SD above the mean for age.
http://purl.obolibrary.org/obo/HP_0000041	Chordee	http://purl.obolibrary.org/obo/HP_6000085	Angulation of penis		A congenital anomaly of the penis characterized by ventral (i.e., downward), lateral, or ventrolateral curvature of the shaft and glans penis of more than 30 degrees.
http://purl.obolibrary.org/obo/HP_0000042	Absent external genitalia	http://purl.obolibrary.org/obo/HP_0000811	Abnormal external genitalia morphology		Lack of external genitalia in a male or female individual.
http://purl.obolibrary.org/obo/HP_0000044	Hypogonadotropic hypogonadism	http://purl.obolibrary.org/obo/HP_0000135	Hypogonadism		Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH).
http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology	http://purl.obolibrary.org/obo/HP_0000032	Abnormal male external genitalia morphology		Any structural abnormality of the scrotum, i.e., the sac that contains the testes, epididymis, and the lower part of the spermatic cord.
http://purl.obolibrary.org/obo/HP_0000046	Small scrotum	http://purl.obolibrary.org/obo/HP_0000050	Hypoplastic male external genitalia		Apparently small scrotum for age.
http://purl.obolibrary.org/obo/HP_0000047	Hypospadias	http://purl.obolibrary.org/obo/HP_0100627	Displacement of the urethral meatus		Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum.
http://purl.obolibrary.org/obo/HP_0000048	Bifid scrotum	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Midline indentation or cleft of the scrotum.
http://purl.obolibrary.org/obo/HP_0000049	Shawl scrotum	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Superior margin of the scrotum superior to the base of the penis.
http://purl.obolibrary.org/obo/HP_0000050	Hypoplastic male external genitalia	http://purl.obolibrary.org/obo/HP_0003241	External genital hypoplasia		Underdevelopment of part or all of the male external reproductive organs (which include the penis, the scrotum and the urethra).
http://purl.obolibrary.org/obo/HP_0000051	Perineal hypospadias	http://purl.obolibrary.org/obo/HP_0000047	Hypospadias		Hypospadias with location of the urethral meatus in the perineal region.
http://purl.obolibrary.org/obo/HP_0000052	Urethral atresia, male	http://purl.obolibrary.org/obo/HP_0000068	Urethral atresia		Congenital anomaly characterized by closure or failure to develop an opening in the urethra in males.
http://purl.obolibrary.org/obo/HP_0000053	Macroorchidism	http://purl.obolibrary.org/obo/HP_0045058	Abnormality of the testis size		The presence of abnormally large testes.
http://purl.obolibrary.org/obo/HP_0000054	Micropenis	http://purl.obolibrary.org/obo/HP_0008736	Hypoplasia of penis		Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm.
http://purl.obolibrary.org/obo/HP_0000055	Abnormal female external genitalia morphology	http://purl.obolibrary.org/obo/HP_0010460	Abnormality of the female genitalia		Any structural abnormality of the female external genitalia.
http://purl.obolibrary.org/obo/HP_0000056	Abnormal clitoris morphology	http://purl.obolibrary.org/obo/HP_0000055	Abnormal female external genitalia morphology		Any structural abnormality of the clitoris.
http://purl.obolibrary.org/obo/HP_0000058	Abnormal labia morphology	http://purl.obolibrary.org/obo/HP_0000055	Abnormal female external genitalia morphology		An anomaly of the labia, the externally visible portions of the vulva.
http://purl.obolibrary.org/obo/HP_0000059	Hypoplastic labia majora	http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology		Undergrowth of the outer labia.
http://purl.obolibrary.org/obo/HP_0000060	Clitoral hypoplasia	http://purl.obolibrary.org/obo/HP_0040255	Aplasia/Hypoplasia of the clitoris		Developmental hypoplasia of the clitoris.
http://purl.obolibrary.org/obo/HP_0000061	Ambiguous genitalia, female	http://purl.obolibrary.org/obo/HP_0000062	Ambiguous genitalia		Ambiguous genitalia in an individual with XX genetic gender.
http://purl.obolibrary.org/obo/HP_0000062	Ambiguous genitalia	http://purl.obolibrary.org/obo/HP_0000811	Abnormal external genitalia morphology		A genital phenotype that is not clearly assignable to a single gender. Ambiguous genitalia can be evaluated using the Prader scale: Prader 0: Normal female external genitalia. Prader 1: Female external genitalia with clitoromegaly. Prader 2: Clitoromegaly with partial labial fusion forming a funnel-shaped urogenital sinus. Prader 3: Increased phallic enlargement. Complete labioscrotal fusion forming a urogenital sinus with a single opening. Prader 4: Complete scrotal fusion with urogenital opening at the base or on the shaft of the phallus. Prader 5: Normal male external genitalia. The diagnosis of ambiguous genitalia is made for Prader 1-4.
http://purl.obolibrary.org/obo/HP_0000063	Fused labia minora	http://purl.obolibrary.org/obo/HP_0012880	Abnormal labia minora morphology		Fusion of the labia minora as a result of labial adhesions resulting in vaginal obstruction.
http://purl.obolibrary.org/obo/HP_0000067	Urethral atresia, female	http://purl.obolibrary.org/obo/HP_0000068	Urethral atresia		Congenital anomaly characterized by closure or failure to develop an opening in the urethra in females.
http://purl.obolibrary.org/obo/HP_0000068	Urethral atresia	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		Congenital anomaly characterized by closure or failure to develop an opening in the urethra.
http://purl.obolibrary.org/obo/HP_0000069	Abnormality of the ureter	http://purl.obolibrary.org/obo/HP_0010935	Abnormality of the upper urinary tract		An abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder.
http://purl.obolibrary.org/obo/HP_0000070	Ureterocele	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		A ureterocele is a congenital saccular dilatation of the distal segment of the ureter.
http://purl.obolibrary.org/obo/HP_0000071	Ureteral stenosis	http://purl.obolibrary.org/obo/HP_0006000	Ureteral obstruction		The presence of a stenotic, i.e., constricted ureter.
http://purl.obolibrary.org/obo/HP_0000072	Hydroureter	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		The distention of the ureter with urine.
http://purl.obolibrary.org/obo/HP_0000073	Ureteral duplication	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		A developmental anomaly characterized by the presence of two, instead of one, ureter connecting a kidney to the bladder.
http://purl.obolibrary.org/obo/HP_0000074	Ureteropelvic junction obstruction	http://purl.obolibrary.org/obo/HP_0000071	Ureteral stenosis		Blockage of urine flow from the renal pelvis to the proximal ureter.
http://purl.obolibrary.org/obo/HP_0000075	Renal duplication	http://purl.obolibrary.org/obo/HP_0005217	Abdominal organ duplication		A congenital anomaly of the urinary tract, in which the kidney is duplicated and is drained via two separate renal pelves and ureters.
http://purl.obolibrary.org/obo/HP_0000076	Vesicoureteral reflux	http://purl.obolibrary.org/obo/HP_0025634	Abnormal ureter physiology		Abnormal (retrograde) movement of urine from the bladder into ureters or kidneys related to inadequacy of the valvular mechanism at the ureterovesicular junction or other causes.
http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the kidney	http://purl.obolibrary.org/obo/HP_0010935	Abnormality of the upper urinary tract		An abnormality of the kidney.
http://purl.obolibrary.org/obo/HP_0000078	Abnormality of the genital system	http://purl.obolibrary.org/obo/HP_0000119	Abnormality of the genitourinary system		An abnormality of the genital system.
http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the urinary system	http://purl.obolibrary.org/obo/HP_0000119	Abnormality of the genitourinary system		An abnormality of the urinary system.
http://purl.obolibrary.org/obo/HP_0000080	Abnormality of reproductive system physiology	http://purl.obolibrary.org/obo/HP_0000078	Abnormality of the genital system		An abnormal functionality of the genital system.
http://purl.obolibrary.org/obo/HP_0000081	Duplicated collecting system	http://purl.obolibrary.org/obo/HP_0004742	Abnormal renal collecting system morphology		A duplication of the collecting system of the kidney, defined as a kidney with two (instead of, normally, one) pyelocaliceal systems. The pyelocaliceal system is comprised of the renal pelvis and calices. The duplicated renal collecting system can be associated with a single ureter or with double ureters. In the latter case, the two ureters empty separately into the bladder or fuse to form a single ureteral orifice.
http://purl.obolibrary.org/obo/HP_0000085	Horseshoe kidney	http://purl.obolibrary.org/obo/HP_0100542	Abnormal localization of kidney		A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline.
http://purl.obolibrary.org/obo/HP_0000086	Ectopic kidney	http://purl.obolibrary.org/obo/HP_0100542	Abnormal localization of kidney		A developmental defect in which a kidney is located in an abnormal anatomic position.
http://purl.obolibrary.org/obo/HP_0000089	Renal hypoplasia	http://purl.obolibrary.org/obo/HP_0008678	Renal hypoplasia/aplasia		Hypoplasia of the kidney.
http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology	http://purl.obolibrary.org/obo/HP_0012575	Abnormal nephron morphology		An abnormality of the renal tubules.
http://purl.obolibrary.org/obo/HP_0000092	Renal tubular atrophy	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		The presence of renal tubules with thick redundant basement membranes, or a reduction of greater than 50% in tubular diameter compared to surrounding non-atrophic tubules.
http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology	http://purl.obolibrary.org/obo/HP_0031263	Abnormal renal corpuscle morphology		A structural anomaly of the glomerulus.
http://purl.obolibrary.org/obo/HP_0000096	Glomerular sclerosis	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Accumulation of scar tissue within the glomerulus.
http://purl.obolibrary.org/obo/HP_0000097	Focal segmental glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0000096	Glomerular sclerosis		Segmental accumulation of scar tissue in individual (but not all) glomeruli.
http://purl.obolibrary.org/obo/HP_0000098	Tall stature	http://purl.obolibrary.org/obo/HP_0000002	Abnormality of body height		A height above that which is expected according to age and gender norms.
http://purl.obolibrary.org/obo/HP_0000099	Glomerulonephritis	http://purl.obolibrary.org/obo/HP_0000123	Nephritis		Inflammation of the renal glomeruli.
http://purl.obolibrary.org/obo/HP_0000100	Nephrotic syndrome	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria. Nephrotic syndrome refers to the constellation of clinical findings that result from severe renal loss of protein, with Proteinuria and hypoalbuminemia, edema, and hyperlipidemia.
http://purl.obolibrary.org/obo/HP_0000103	Polyuria	http://purl.obolibrary.org/obo/HP_0012590	Abnormal urine output		An increased rate of urine production.
http://purl.obolibrary.org/obo/HP_0000104	Renal agenesis	http://purl.obolibrary.org/obo/HP_0008678	Renal hypoplasia/aplasia		Agenesis, that is, failure of the kidney to develop during embryogenesis and development.
http://purl.obolibrary.org/obo/HP_0000105	Enlarged kidney	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An abnormal increase in the size of the kidney.
http://purl.obolibrary.org/obo/HP_0000107	Renal cyst	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		A fluid filled sac in the kidney.
http://purl.obolibrary.org/obo/HP_0000108	Renal corticomedullary cysts	http://purl.obolibrary.org/obo/HP_0100957	Abnormal renal medulla morphology		The presence of multiple cysts at the border between the renal cortex and medulla.
http://purl.obolibrary.org/obo/HP_0000110	Renal dysplasia	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		The presence of developmental dysplasia of the kidney.
http://purl.obolibrary.org/obo/HP_0000111	Renal juxtaglomerular cell hypertrophy/hyperplasia	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Increased number and size of the juxtaglomerular cells.
http://purl.obolibrary.org/obo/HP_0000112	Nephropathy	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		A nonspecific term referring to disease or damage of the kidneys.
http://purl.obolibrary.org/obo/HP_0000113	Polycystic kidney dysplasia	http://purl.obolibrary.org/obo/HP_0000107	Renal cyst		The presence of multiple cysts in both kidneys.
http://purl.obolibrary.org/obo/HP_0000114	Proximal tubulopathy	http://purl.obolibrary.org/obo/HP_0000124	Renal tubular dysfunction		Dysfunction of the proximal tubule, which is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle.
http://purl.obolibrary.org/obo/HP_0000117	Renal phosphate wasting	http://purl.obolibrary.org/obo/HP_0012599	Abnormal urine phosphate concentration		High urine phosphate in the presence of hypophosphatemia.
http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality	http://purl.obolibrary.org/obo/HP_0000001	All		A phenotypic abnormality.
http://purl.obolibrary.org/obo/HP_0000119	Abnormality of the genitourinary system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		The presence of any abnormality of the genitourinary system.
http://purl.obolibrary.org/obo/HP_0000121	Nephrocalcinosis	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Nephrocalcinosis is the deposition of calcium salts in renal parenchyma.
http://purl.obolibrary.org/obo/HP_0000122	Unilateral renal agenesis	http://purl.obolibrary.org/obo/HP_0000104	Renal agenesis		A unilateral form of agenesis of the kidney.
http://purl.obolibrary.org/obo/HP_0000123	Nephritis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		The presence of inflammation affecting the kidney.
http://purl.obolibrary.org/obo/HP_0000124	Renal tubular dysfunction	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		Abnormal function of the renal tubule. The basic functional unit of the kidney, the nephron, consists of a renal corpuscle attached to a renal tubule, with roughly 0.8 to 1.5 nephrons per adult kidney. The functions of the renal tubule include reabsorption of water, electrolytes, glucose, and amino acids and secretion of substances such as uric acid.
http://purl.obolibrary.org/obo/HP_0000125	Pelvic kidney	http://purl.obolibrary.org/obo/HP_0000086	Ectopic kidney		A developmental defect in which a kidney is located in an abnormal anatomic position within the pelvis.
http://purl.obolibrary.org/obo/HP_0000126	Hydronephrosis	http://purl.obolibrary.org/obo/HP_0010946	Dilatation of the renal pelvis		Severe distention of the kidney with dilation of the renal pelvis and calices.
http://purl.obolibrary.org/obo/HP_0000127	Renal salt wasting	http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration		A high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s).
http://purl.obolibrary.org/obo/HP_0000128	Renal potassium wasting	http://purl.obolibrary.org/obo/HP_0012598	Abnormal urine potassium concentration		High urine potassium in the presence of hypokalemia.
http://purl.obolibrary.org/obo/HP_0000130	Abnormality of the uterus	http://purl.obolibrary.org/obo/HP_0000008	Abnormal morphology of female internal genitalia		An abnormality of the uterus.
http://purl.obolibrary.org/obo/HP_0000131	Uterine leiomyoma	http://purl.obolibrary.org/obo/HP_0010784	Uterine neoplasm		The presence of a leiomyoma of the uterus.
http://purl.obolibrary.org/obo/HP_0000133	Gonadal dysgenesis	http://purl.obolibrary.org/obo/HP_0000812	Abnormal internal genitalia		Gonadal dysgenesis is the name given to any of a multitude of conditions that can cause impaired development of the gonads, i.e., the testes or ovaries, or to the related phenotypic features. The term is to be avoided if possible for new annotations, and more specific terms should be chosen.
http://purl.obolibrary.org/obo/HP_0000134	Female hypogonadism	http://purl.obolibrary.org/obo/HP_0031066	Abnormal ovarian physiology		Decreased functionality of the female gonads, i.e., of the ovary.
http://purl.obolibrary.org/obo/HP_0000135	Hypogonadism	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		A decreased functionality of the gonad.
http://purl.obolibrary.org/obo/HP_0000136	Bifid uterus	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		The presence of a bifid uterus.
http://purl.obolibrary.org/obo/HP_0000137	Abnormality of the ovary	http://purl.obolibrary.org/obo/HP_0000008	Abnormal morphology of female internal genitalia		An abnormality of the ovary.
http://purl.obolibrary.org/obo/HP_0000138	Ovarian cyst	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		The presence of one or more cysts of the ovary.
http://purl.obolibrary.org/obo/HP_0000139	Uterine prolapse	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		The presence of prolapse of the uterus.
http://purl.obolibrary.org/obo/HP_0000140	Abnormality of the menstrual cycle	http://purl.obolibrary.org/obo/HP_0030012	Abnormal female reproductive system physiology		An abnormality of the ovulation cycle.
http://purl.obolibrary.org/obo/HP_0000141	Amenorrhea	http://purl.obolibrary.org/obo/HP_0000140	Abnormality of the menstrual cycle		Absence of menses for an interval of time equivalent to a total of more than (or equal to) 3 previous cycles or 6 months.
http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology	http://purl.obolibrary.org/obo/HP_0000008	Abnormal morphology of female internal genitalia		Any structural abnormality of the vagina.
http://purl.obolibrary.org/obo/HP_0000143	Rectovaginal fistula	http://purl.obolibrary.org/obo/HP_0100590	Rectal fistula		The presence of a fistula between the vagina and the rectum.
http://purl.obolibrary.org/obo/HP_0000148	Vaginal atresia	http://purl.obolibrary.org/obo/HP_0001827	Genital tract atresia		Congenital occlusion of the vagina or adhesion of the walls of the vagina causing occlusion.
http://purl.obolibrary.org/obo/HP_0000149	Ovarian gonadoblastoma	http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm		The presence of a gonadoblastoma of the ovary.
http://purl.obolibrary.org/obo/HP_0000150	Gonadoblastoma	http://purl.obolibrary.org/obo/HP_0100728	Germ cell neoplasia		The presence of a gonadoblastoma, a neoplasm of a gonad that consists of aggregates of germ cells and sex cord elements.
http://purl.obolibrary.org/obo/HP_0000151	Aplasia of the uterus	http://purl.obolibrary.org/obo/HP_0008684	Aplasia/hypoplasia of the uterus		A congenital defect characterized by absence of the uterus. Aplasia refers to the failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue.
http://purl.obolibrary.org/obo/HP_0000152	Abnormality of head or neck	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of head and neck.
http://purl.obolibrary.org/obo/HP_0000153	Abnormality of the mouth	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		An abnormality of the mouth.
http://purl.obolibrary.org/obo/HP_0000154	Wide mouth	http://purl.obolibrary.org/obo/HP_0011337	Abnormality of mouth size		Distance between the oral commissures more than 2 SD above the mean. Alternatively, an apparently increased width of the oral aperture (subjective).
http://purl.obolibrary.org/obo/HP_0000155	Oral ulcer	http://purl.obolibrary.org/obo/HP_0031446	Erosion of oral mucosa		Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue.
http://purl.obolibrary.org/obo/HP_0000157	Abnormality of the tongue	http://purl.obolibrary.org/obo/HP_0000153	Abnormality of the mouth		Any abnormality of the tongue.
http://purl.obolibrary.org/obo/HP_0000158	Macroglossia	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Increased length and width of the tongue.
http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		An abnormality of the lip.
http://purl.obolibrary.org/obo/HP_0000160	Narrow mouth	http://purl.obolibrary.org/obo/HP_0011337	Abnormality of mouth size		Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective).
http://purl.obolibrary.org/obo/HP_0000161	Median cleft upper lip	http://purl.obolibrary.org/obo/HP_0000204	Cleft upper lip		A type of cleft lip presenting as a midline (median) gap in the upper lip.
http://purl.obolibrary.org/obo/HP_0000162	Glossoptosis	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Posterior displacement of the tongue into the pharynx, i.e., a tongue that is mislocalised posteriorly.
http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology	http://purl.obolibrary.org/obo/HP_0031816	Abnormal oral morphology		Abnormality of the oral cavity, i.e., the opening or hollow part of the mouth.
http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		Any abnormality of the teeth.
http://purl.obolibrary.org/obo/HP_0000166	Severe periodontitis	http://purl.obolibrary.org/obo/HP_0020341	Unusual periodontitis		Increased susceptibility to periodontitis, as manifested by severe periodontal infection with rapid alveolar bone loss, tooth mobility, and premature tooth exfoliation.
http://purl.obolibrary.org/obo/HP_0000168	Abnormality of the gingiva	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		Any abnormality of the gingiva (also known as gums).
http://purl.obolibrary.org/obo/HP_0000169	Gingival fibromatosis	http://purl.obolibrary.org/obo/HP_0010614	Fibroma		The presence of fibrosis of the gingiva.
http://purl.obolibrary.org/obo/HP_0000171	Microglossia	http://purl.obolibrary.org/obo/HP_0010295	Aplasia/Hypoplasia of the tongue		Decreased length and width of the tongue.
http://purl.obolibrary.org/obo/HP_0000172	Abnormal uvula morphology	http://purl.obolibrary.org/obo/HP_0100736	Abnormal soft palate morphology		Abnormality of the uvula, the conic projection from the posterior edge of the middle of the soft palate.
http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		Any abnormality of the palate, i.e., of roof of the mouth.
http://purl.obolibrary.org/obo/HP_0000175	Cleft palate	http://purl.obolibrary.org/obo/HP_0000202	Orofacial cleft		Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate).
http://purl.obolibrary.org/obo/HP_0000176	Submucous cleft hard palate	http://purl.obolibrary.org/obo/HP_0410005	Cleft hard palate		Hard-palate submucous clefts are characterized by bony defects in the midline of the bony palate that are covered by the mucous membrane of the roof of the mouth. It may be possible to detect a submucous cleft hard palate upon palpation as a notch in the bony palate.
http://purl.obolibrary.org/obo/HP_0000177	Abnormal upper lip morphology	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		An abnormality of the upper lip.
http://purl.obolibrary.org/obo/HP_0000178	Abnormal lower lip morphology	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		An abnormality of the lower lip.
http://purl.obolibrary.org/obo/HP_0000179	Thick lower lip vermilion	http://purl.obolibrary.org/obo/HP_0012471	Thick vermilion border		Increased thickness of the lower lip, leading to a prominent appearance of the lower lip. The height of the vermilion of the lower lip in the midline is more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the lower lip in the frontal view (subjective).
http://purl.obolibrary.org/obo/HP_0000180	Lobulated tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Multiple indentations and/or elevations on the edge and/or surface of the tongue producing an irregular surface contour.
http://purl.obolibrary.org/obo/HP_0000183	Tongue muscle weakness	http://purl.obolibrary.org/obo/HP_0000182	Movement abnormality of the tongue		Reduced strength of the tongue musculature, resulting in difficulties moving the tongue and possible accompanied by dysarthria or dysphagia.
http://purl.obolibrary.org/obo/HP_0000185	Cleft soft palate	http://purl.obolibrary.org/obo/HP_0100736	Abnormal soft palate morphology		Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency.
http://purl.obolibrary.org/obo/HP_0000188	Short upper lip	http://purl.obolibrary.org/obo/HP_0000177	Abnormal upper lip morphology		Decreased width of the upper lip.
http://purl.obolibrary.org/obo/HP_0000189	Narrow palate	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		Width of the palate more than 2 SD below the mean (objective) or apparently decreased palatal width (subjective).
http://purl.obolibrary.org/obo/HP_0000190	Abnormal oral frenulum morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		An abnormality of the lingual frenulum, that is of the small fold of mucous membrane that attaches the tongue to the floor of the mouth, or the presence of accessory frenula in the oral cavity.
http://purl.obolibrary.org/obo/HP_0000191	Accessory oral frenulum	http://purl.obolibrary.org/obo/HP_0000190	Abnormal oral frenulum morphology		Extra fold of tissue extending from the alveolar ridge to the inner surface of the upper or lower lip.
http://purl.obolibrary.org/obo/HP_0000193	Bifid uvula	http://purl.obolibrary.org/obo/HP_0000172	Abnormal uvula morphology		Uvula separated into two parts most easily seen at the tip.
http://purl.obolibrary.org/obo/HP_0000194	Open mouth	http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape		A facial appearance characterized by a permanently or nearly permanently opened mouth.
http://purl.obolibrary.org/obo/HP_0000196	Lower lip pit	http://purl.obolibrary.org/obo/HP_0100269	Paramedian lip pit		Depression located on the vermilion of the lower lip, usually paramedian.
http://purl.obolibrary.org/obo/HP_0000197	Abnormal parotid gland morphology	http://purl.obolibrary.org/obo/HP_0010286	Abnormal salivary gland morphology		Any abnormality of the parotid glands, which are the salivary glands that are located in the subcutaneous tissues of the face overlying the mandibular ramus and anterior and inferior to the external ear.
http://purl.obolibrary.org/obo/HP_0000200	Short lingual frenulum	http://purl.obolibrary.org/obo/HP_0000190	Abnormal oral frenulum morphology		The presence of an abnormally short lingual frenulum.
http://purl.obolibrary.org/obo/HP_0000201	Pierre-Robin sequence	http://purl.obolibrary.org/obo/HP_0031816	Abnormal oral morphology		Pierre Robin malformation is a sequence of developmental malformations characterized by micrognathia (mandibular hypoplasia), glossoptosis and cleft palate.
http://purl.obolibrary.org/obo/HP_0000202	Orofacial cleft	http://purl.obolibrary.org/obo/HP_5201015	Craniofacial cleft		The presence of a cleft (gap, opening, or groove) in the oral cavity, including cleft of the upper lip and/or cleft of the palate. Cleft of the upper lip is visible as a groove or fissure in the lip, most frequently due to a congenital failure of the maxillary and median nasal processes to fuse. Cleft palate is characterized by a grooved depression or fissure in the roof of the mouth, most often resulting from a congenital failure of the palate to fuse properly. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately.
http://purl.obolibrary.org/obo/HP_0000204	Cleft upper lip	http://purl.obolibrary.org/obo/HP_0410030	Cleft lip		A gap or groove in the upper lip. This is a congenital defect resulting from nonfusion of tissues of the lip during embryonal development.
http://purl.obolibrary.org/obo/HP_0000205	Pursed lips	http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape		An abnormality of the appearance of the face caused by constant contraction of the lips leading to a puckered or pursed appearance.
http://purl.obolibrary.org/obo/HP_0000206	Glossitis	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Inflammation of the tongue.
http://purl.obolibrary.org/obo/HP_0000207	Triangular mouth	http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape		The presence of a triangular form of the mouth.
http://purl.obolibrary.org/obo/HP_0000211	Trismus	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		Limitation in the ability to open the mouth.
http://purl.obolibrary.org/obo/HP_0000212	Gingival overgrowth	http://purl.obolibrary.org/obo/HP_0000168	Abnormality of the gingiva		Hyperplasia of the gingiva (that is, a thickening of the soft tissue overlying the alveolar ridge. The degree of thickening ranges from involvement of the interdental papillae alone to gingival overgrowth covering the entire tooth crown.
http://purl.obolibrary.org/obo/HP_0000214	Lip telangiectasia	http://purl.obolibrary.org/obo/HP_0000228	Oral cavity telangiectasia		Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the lips.
http://purl.obolibrary.org/obo/HP_0000215	Thick upper lip vermilion	http://purl.obolibrary.org/obo/HP_0012471	Thick vermilion border		Height of the vermilion of the upper lip in the midline more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the upper lip in the frontal view (subjective).
http://purl.obolibrary.org/obo/HP_0000217	Xerostomia	http://purl.obolibrary.org/obo/HP_0100755	Abnormality of salivation		Dryness of the mouth due to salivary gland dysfunction.
http://purl.obolibrary.org/obo/HP_0000218	High palate	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective).
http://purl.obolibrary.org/obo/HP_0000219	Thin upper lip vermilion	http://purl.obolibrary.org/obo/HP_0011339	Abnormality of upper lip vermillion		Height of the vermilion of the upper lip in the midline more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the upper lip in the frontal view (subjective).
http://purl.obolibrary.org/obo/HP_0000220	Velopharyngeal insufficiency	http://purl.obolibrary.org/obo/HP_0100736	Abnormal soft palate morphology		Inability of velopharyngeal sphincter to sufficiently separate the nasal cavity from the oral cavity during speech.
http://purl.obolibrary.org/obo/HP_0000221	Furrowed tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Accentuation of the grooves on the dorsal surface of the tongue.
http://purl.obolibrary.org/obo/HP_0000222	Gingival hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		Hyperkeratosis of the gingiva.
http://purl.obolibrary.org/obo/HP_0000224	Hypogeusia	http://purl.obolibrary.org/obo/HP_0000223	Abnormality of taste sensation		A decreased ability to perceive flavor.
http://purl.obolibrary.org/obo/HP_0000225	Gingival bleeding	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Hemorrhage affecting the gingiva.
http://purl.obolibrary.org/obo/HP_0000227	Tongue telangiectasia	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the tongue.
http://purl.obolibrary.org/obo/HP_0000228	Oral cavity telangiectasia	http://purl.obolibrary.org/obo/HP_0100579	Mucosal telangiectasiae		Presence of telangiectases in the oral cavity.
http://purl.obolibrary.org/obo/HP_0000230	Gingivitis	http://purl.obolibrary.org/obo/HP_5210280	Unusual oral cavity infection		Inflammation of the gingiva
http://purl.obolibrary.org/obo/HP_0000232	Everted lower lip vermilion	http://purl.obolibrary.org/obo/HP_0012472	Eclabion		An abnormal configuration of the lower lip such that it is turned outward i.e., everted, with the Inner aspect of the lower lip vermilion (normally opposing the teeth) being visible in a frontal view.
http://purl.obolibrary.org/obo/HP_0000233	Thin vermilion border	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Height of the vermilion of the medial part of the lip more than 2 SD below the mean, or apparently reduced height of the vermilion of the lip in the frontal view. The vermilion is the red part of the lips (and confusingly, the vermilion itself is also often referred to as being equivalent the lips).
http://purl.obolibrary.org/obo/HP_0000234	Abnormality of the head	http://purl.obolibrary.org/obo/HP_0000152	Abnormality of head or neck		An abnormality of the head.
http://purl.obolibrary.org/obo/HP_0000235	Abnormal cranial suture/fontanelle morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		Any abnormality of the fontanelles (the regions covered by a thick membrane that normally ossify in the first two years of life) or the cranial sutures (the fibrous joints in which the articulating bones or cartilages of the skull are connected by sutural ligaments).
http://purl.obolibrary.org/obo/HP_0000236	Abnormal anterior fontanelle morphology	http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology		An abnormality of the anterior fontanelle, i.e., the cranial fontanelle that is located at the intersection of the coronal and sagittal sutures.
http://purl.obolibrary.org/obo/HP_0000237	Small anterior fontanelle	http://purl.obolibrary.org/obo/HP_0000236	Abnormal anterior fontanelle morphology		Abnormally decreased size of the anterior fontanelle with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0000239	Large fontanelles	http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology		In newborns, the two frontal bones, two parietal bones, and one occipital bone are joined by fibrous sutures, which form a small posterior fontanelle, and a larger, diamond-shaped anterior fontanelle. These regions allow for the skull to pass the birth canal and for later growth. The fontanelles gradually ossify, whereby the posterior fontanelle usually closes by eight weeks and the anterior fontanelle by the 9th to 16th month of age. Large fontanelles are diagnosed if the fontanelles are larger than age-dependent norms.
http://purl.obolibrary.org/obo/HP_0000240	Abnormality of skull size	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		Any abnormality of the size of the skull.
http://purl.obolibrary.org/obo/HP_0000242	Parietal bossing	http://purl.obolibrary.org/obo/HP_0002696	Abnormal parietal bone morphology		Parietal bossing is a marked prominence in the parietal region.
http://purl.obolibrary.org/obo/HP_0000243	Trigonocephaly	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Wedge-shaped, or triangular head, with the apex of the triangle at the midline of the forehead and the base of the triangle at the occiput.
http://purl.obolibrary.org/obo/HP_0000244	Brachyturricephaly	http://purl.obolibrary.org/obo/HP_0000262	Turricephaly		Abnormal vertical height of the skull and a shortening of its anterior-posterior length, frequently combined with malformations of the occipital region.
http://purl.obolibrary.org/obo/HP_0000245	Abnormal paranasal sinus morphology	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		Abnormality of the paranasal (cranial) sinuses, which are air-filled spaces that are located within the bones of the skull and face and communicate with the nasal cavity. They comprise the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses.
http://purl.obolibrary.org/obo/HP_0000246	Sinusitis	http://purl.obolibrary.org/obo/HP_5210121	Unusual upper respiratory tract infection		Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction.
http://purl.obolibrary.org/obo/HP_0000248	Brachycephaly	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		An abnormality of skull shape characterized by a decreased anterior-posterior diameter. That is, a cephalic index greater than 81%. Alternatively, an apparently shortened anteroposterior dimension (length) of the head compared to width.
http://purl.obolibrary.org/obo/HP_0000250	Dense calvaria	http://purl.obolibrary.org/obo/HP_0004330	Increased skull ossification		An abnormal increase of density of the bones making up the calvaria.
http://purl.obolibrary.org/obo/HP_0000253	Progressive microcephaly	http://purl.obolibrary.org/obo/HP_0005484	Secondary microcephaly		Progressive microcephaly is diagnosed when the head circumference falls progressively behind age- and gender-dependent norms.
http://purl.obolibrary.org/obo/HP_0000255	Acute sinusitis	http://purl.obolibrary.org/obo/HP_0000246	Sinusitis		An acute form of sinusitis.
http://purl.obolibrary.org/obo/HP_0000256	Macrocephaly	http://purl.obolibrary.org/obo/HP_0040194	Increased head circumference		Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium.
http://purl.obolibrary.org/obo/HP_0000260	Wide anterior fontanel	http://purl.obolibrary.org/obo/HP_0000239	Large fontanelles		Enlargement of the anterior fontanelle with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0000262	Turricephaly	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Tall head relative to width and length.
http://purl.obolibrary.org/obo/HP_0000263	Oxycephaly	http://purl.obolibrary.org/obo/HP_0000262	Turricephaly		Oxycephaly (from Greek oxus, sharp, and kephalos, head) refers to a conical or pointed shape of the skull.
http://purl.obolibrary.org/obo/HP_0000264	Abnormal mastoid morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		An abnormality of the mastoid process, which is the conical prominence projecting from the undersurface of the mastoid portion of the temporal bone.
http://purl.obolibrary.org/obo/HP_0000267	Cranial asymmetry	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Asymmetry of the bones of the skull.
http://purl.obolibrary.org/obo/HP_0000268	Dolichocephaly	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		An abnormality of skull shape characterized by a increased anterior-posterior diameter, i.e., an increased antero-posterior dimension of the skull. Cephalic index less than 76%. Alternatively, an apparently increased antero-posterior length of the head compared to width. Often due to premature closure of the sagittal suture.
http://purl.obolibrary.org/obo/HP_0000269	Prominent occiput	http://purl.obolibrary.org/obo/HP_0011217	Abnormal shape of the occiput		Increased convexity of the occiput (posterior part of the skull).
http://purl.obolibrary.org/obo/HP_0000270	Delayed cranial suture closure	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		Infants normally have two fontanels at birth, the diamond-shaped anterior fontanelle at the junction of the coronal and sagittal sutures, and the posterior fontanelle at the intersection of the occipital and parietal bones. The posterior fontanelle usually closes by the 8th week of life, and the anterior fontanel closes by the 18th month of life on average. This term applies if there is delay of closure of the fontanelles beyond the normal age.
http://purl.obolibrary.org/obo/HP_0000274	Small face	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		A face that is short and narrow.
http://purl.obolibrary.org/obo/HP_0000276	Long face	http://purl.obolibrary.org/obo/HP_0100729	Large face		Facial height (length) is more than 2 standard deviations above the mean (objective); or, an apparent increase in the height (length) of the face (subjective).
http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology	http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology		Any abnormality of the mandible, the bone of the lower jaw.
http://purl.obolibrary.org/obo/HP_0000280	Coarse facial features	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues.
http://purl.obolibrary.org/obo/HP_0000283	Broad face	http://purl.obolibrary.org/obo/HP_0100729	Large face		Bizygomatic (upper face) and bigonial (lower face) width greater than 2 standard deviations above the mean (objective); or an apparent increase in the width of the face (subjective).
http://purl.obolibrary.org/obo/HP_0000286	Epicanthus	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus.
http://purl.obolibrary.org/obo/HP_0000287	Increased facial adipose tissue	http://purl.obolibrary.org/obo/HP_0000291	Abnormality of facial adipose tissue		An increased amount of subcutaneous fat tissue in the face.
http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum	http://purl.obolibrary.org/obo/HP_0000177	Abnormal upper lip morphology		An abnormality of the philtrum.
http://purl.obolibrary.org/obo/HP_0000289	Broad philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations above the mean, or alternatively, an apparently increased distance between the ridges of the philtrum.
http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		An anomaly of the forehead.
http://purl.obolibrary.org/obo/HP_0000292	Loss of facial adipose tissue	http://purl.obolibrary.org/obo/HP_0008887	Adipose tissue loss		Loss of normal subcutaneous fat tissue in the face.
http://purl.obolibrary.org/obo/HP_0000293	Full cheeks	http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology		Increased prominence or roundness of soft tissues between zygomata and mandible.
http://purl.obolibrary.org/obo/HP_0000294	Low anterior hairline	http://purl.obolibrary.org/obo/HP_0000599	Abnormality of the frontal hairline		Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella.
http://purl.obolibrary.org/obo/HP_0000295	Doll-like facies	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		A characteristic facial appearance with a round facial form, full cheeks, a short nose, and a relatively small chin.
http://purl.obolibrary.org/obo/HP_0000297	Facial hypotonia	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		Reduced muscle tone of a muscle that is innervated by the facial nerve (the seventh cranial nerve).
http://purl.obolibrary.org/obo/HP_0000298	Mask-like facies	http://purl.obolibrary.org/obo/HP_0004673	Decreased facial expression		A lack of facial expression often with staring eyes and a slightly open mouth.
http://purl.obolibrary.org/obo/HP_0000300	Oval face	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		A face with a rounded and slightly elongated outline.
http://purl.obolibrary.org/obo/HP_0000301	Abnormality of facial musculature	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		An anomaly of a muscle that is innervated by the facial nerve (the seventh cranial nerve).
http://purl.obolibrary.org/obo/HP_0000303	Mandibular prognathia	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		Abnormal prominence of the chin related to increased length of the mandible.
http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		An abnormality of the chin, i.e., of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw.
http://purl.obolibrary.org/obo/HP_0000307	Pointed chin	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		A marked tapering of the lower face to the chin.
http://purl.obolibrary.org/obo/HP_0000308	Microretrognathia	http://purl.obolibrary.org/obo/HP_0000347	Micrognathia		A form of developmental hypoplasia of the mandible in which the mandible is mislocalised posteriorly.
http://purl.obolibrary.org/obo/HP_0000309	Abnormal midface morphology	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		An anomaly of the midface, which is a region and not an anatomical term. It extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base. It is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region. Traditionally, the nose and premaxilla are not included in the midface.
http://purl.obolibrary.org/obo/HP_0000311	Round face	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		The facial appearance is more circular than usual as viewed from the front.
http://purl.obolibrary.org/obo/HP_0000316	Hypertelorism	http://purl.obolibrary.org/obo/HP_0100886	Abnormality of globe location		Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).
http://purl.obolibrary.org/obo/HP_0000317	Facial myokymia	http://purl.obolibrary.org/obo/HP_0002411	Myokymia		Facial myokymia is a fine fibrillary activity of one or more muscles innervated by the facial nerve (the seventh cranial nerve).
http://purl.obolibrary.org/obo/HP_0000319	Smooth philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Flat skin surface, with no ridge formation in the central region of the upper lip between the nasal base and upper vermilion border.
http://purl.obolibrary.org/obo/HP_0000321	Square face	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		Facial contours, as viewed from the front, show a broad upper face/cranium and lower face/mandible, creating a square appearance.
http://purl.obolibrary.org/obo/HP_0000322	Short philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Distance between nasal base and midline upper lip vermilion border more than 2 SD below the mean. Alternatively, an apparently decreased distance between nasal base and midline upper lip vermilion border.
http://purl.obolibrary.org/obo/HP_0000324	Facial asymmetry	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		An abnormal difference between the left and right sides of the face.
http://purl.obolibrary.org/obo/HP_0000325	Triangular face	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		Facial contour, as viewed from the front, triangular in shape, with breadth at the temples and tapering to a narrow chin.
http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology	http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology		An abnormality of the Maxilla (upper jaw bone).
http://purl.obolibrary.org/obo/HP_0000327	Hypoplasia of the maxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		Abnormally small dimension of the Maxilla. Usually creating a malocclusion or malalignment between the upper and lower teeth or resulting in a deficient amount of projection of the base of the nose and lower midface region.
http://purl.obolibrary.org/obo/HP_0000329	Facial hemangioma	http://purl.obolibrary.org/obo/HP_0011799	Abnormality of facial soft tissue		Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the face.
http://purl.obolibrary.org/obo/HP_0000331	Short chin	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		Decreased vertical distance from the vermilion border of the lower lip to the inferior-most point of the chin.
http://purl.obolibrary.org/obo/HP_0000336	Prominent supraorbital ridges	http://purl.obolibrary.org/obo/HP_0100538	Abnormality of the supraorbital ridges		Greater than average forward and/or lateral protrusion of the supraorbital portion of the frontal bones.
http://purl.obolibrary.org/obo/HP_0000337	Broad forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		Width of the forehead or distance between the frontotemporales is more than two standard deviations above the mean (objective); or apparently increased distance between the two sides of the forehead.
http://purl.obolibrary.org/obo/HP_0000338	Hypomimic face	http://purl.obolibrary.org/obo/HP_0004673	Decreased facial expression		A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation.
http://purl.obolibrary.org/obo/HP_0000339	Pugilistic facies	http://purl.obolibrary.org/obo/HP_0000280	Coarse facial features		Coarse facial features reminiscent of those of a boxer.
http://purl.obolibrary.org/obo/HP_0000340	Sloping forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		Inclination of the anterior surface of the forehead from the vertical more than two standard deviations above the mean (objective); or apparently excessive posterior sloping of the forehead in a lateral view.
http://purl.obolibrary.org/obo/HP_0000341	Narrow forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		Width of the forehead or distance between the frontotemporales is more than two standard deviations below the mean (objective); or apparently narrow intertemporal region (subjective).
http://purl.obolibrary.org/obo/HP_0000343	Long philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Distance between nasal base and midline upper lip vermilion border more than 2 SD above the mean. Alternatively, an apparently increased distance between nasal base and midline upper lip vermilion border.
http://purl.obolibrary.org/obo/HP_0000346	Whistling appearance	http://purl.obolibrary.org/obo/HP_0000205	Pursed lips		An abnormality of facial morphology characterized by a small mouth opening and constant contraction of the lips as if the patient were whistling.
http://purl.obolibrary.org/obo/HP_0000348	High forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		An abnormally increased height of the forehead.
http://purl.obolibrary.org/obo/HP_0000349	Widow's peak	http://purl.obolibrary.org/obo/HP_0009890	High anterior hairline		Frontal hairline with bilateral arcs to a low point in the midline of the forehead.
http://purl.obolibrary.org/obo/HP_0000350	Small forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		The presence of a forehead that is abnormally small.
http://purl.obolibrary.org/obo/HP_0000356	Abnormality of the outer ear	http://purl.obolibrary.org/obo/HP_0031703	Abnormal ear morphology		An abnormality of the external ear.
http://purl.obolibrary.org/obo/HP_0000357	Abnormal location of ears	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Abnormal location of the ear.
http://purl.obolibrary.org/obo/HP_0000358	Posteriorly rotated ears	http://purl.obolibrary.org/obo/HP_0000357	Abnormal location of ears		A type of abnormal location of the ears in which the position of the ears is characterized by posterior rotation (the superior part of the ears is rotated towards the back of the head, and the inferior part of the ears towards the front).
http://purl.obolibrary.org/obo/HP_0000359	Abnormality of the inner ear	http://purl.obolibrary.org/obo/HP_0031703	Abnormal ear morphology		An abnormality of the inner ear.
http://purl.obolibrary.org/obo/HP_0000360	Tinnitus	http://purl.obolibrary.org/obo/HP_0000364	Hearing abnormality		Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation.
http://purl.obolibrary.org/obo/HP_0000362	Otosclerosis	http://purl.obolibrary.org/obo/HP_0008628	Abnormal stapes morphology		In otosclerosis, a callus of bone accumulates on the stapes creating a partial fixation. This limits the movement of the stapes bone, which results in hearing loss.
http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		An abnormality of the lobule of pinna.
http://purl.obolibrary.org/obo/HP_0000364	Hearing abnormality	http://purl.obolibrary.org/obo/HP_0031704	Abnormal ear physiology		An abnormality of the sensory perception of sound.
http://purl.obolibrary.org/obo/HP_0000366	Abnormality of the nose	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		An abnormality of the nose.
http://purl.obolibrary.org/obo/HP_0000369	Low-set ears	http://purl.obolibrary.org/obo/HP_0000357	Abnormal location of ears		Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear.
http://purl.obolibrary.org/obo/HP_0000370	Abnormality of the middle ear	http://purl.obolibrary.org/obo/HP_0031703	Abnormal ear morphology		An abnormality of the middle ear.
http://purl.obolibrary.org/obo/HP_0000371	Acute otitis media	http://purl.obolibrary.org/obo/HP_0000388	Otitis media		Acute otitis media is a short and generally painful infection of the middle ear.
http://purl.obolibrary.org/obo/HP_0000372	Abnormal auditory canal morphology	http://purl.obolibrary.org/obo/HP_0000356	Abnormality of the outer ear		Any structural abnormality of the external acoustic tube (also known as the auditory canal).
http://purl.obolibrary.org/obo/HP_0000375	Abnormal cochlea morphology	http://purl.obolibrary.org/obo/HP_0011390	Abnormal inner ear morphology		An abnormality of the cochlea.
http://purl.obolibrary.org/obo/HP_0000376	Incomplete partition of the cochlea type II	http://purl.obolibrary.org/obo/HP_0011373	Incomplete partition of the cochlea		With incomplete partition II, the cochlea consists of 1.5 turns; the apical and middle cochlea turns are undifferentiated and form a cystic apex. The vestibule is normal while the vestibular aqueduct is always enlarged. Developmental arrest occurs at the seventh week of gestation.
http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology	http://purl.obolibrary.org/obo/HP_0000356	Abnormality of the outer ear		An abnormality of the pinna, which is also referred to as the auricle or external ear.
http://purl.obolibrary.org/obo/HP_0000378	Cupped ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Laterally protruding ear that lacks antihelical folding (including absence of inferior and superior crura).
http://purl.obolibrary.org/obo/HP_0000381	Stapes ankylosis	http://purl.obolibrary.org/obo/HP_0008628	Abnormal stapes morphology		Stapes ankylosis refers to congenital or acquired fixation of the stapes (the stirrup-shaped small bone or ossicle in the middle ear), which is associated with conductive hearing resulting from impairment of the sound-conduction mechanism (the external auditory canal, tympanic membrane, and/or middle-ear ossicles).
http://purl.obolibrary.org/obo/HP_0000384	Preauricular skin tag	http://purl.obolibrary.org/obo/HP_0010609	Skin tags		A rudimentary tag of skin often containing ear tissue including a core of cartilage and located just anterior to the auricle (outer part of the ear).
http://purl.obolibrary.org/obo/HP_0000385	Small earlobe	http://purl.obolibrary.org/obo/HP_0009906	Aplasia/Hypoplasia of the earlobes		Reduced volume of the earlobe.
http://purl.obolibrary.org/obo/HP_0000387	Absent earlobe	http://purl.obolibrary.org/obo/HP_0009906	Aplasia/Hypoplasia of the earlobes		Absence of fleshy non-cartilaginous tissue inferior to the tragus and incisura.
http://purl.obolibrary.org/obo/HP_0000388	Otitis media	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation or infection of the middle ear.
http://purl.obolibrary.org/obo/HP_0000389	Chronic otitis media	http://purl.obolibrary.org/obo/HP_0000388	Otitis media		Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear.
http://purl.obolibrary.org/obo/HP_0000391	Thickened helices	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Increased thickness of the helix of the ear.
http://purl.obolibrary.org/obo/HP_0000394	Lop ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Anterior and inferior folding of the upper portion of the ear that obliterates triangular fossa and scapha.
http://purl.obolibrary.org/obo/HP_0000395	Prominent antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		The presence of an abnormally prominent antihelix.
http://purl.obolibrary.org/obo/HP_0000396	Overfolded helix	http://purl.obolibrary.org/obo/HP_0008544	Abnormally folded helix		A condition in which the helix is folded over to a greater degree than normal. That is, excessive curling of the helix edge, whereby the free edge is parallel to the plane of the ear.
http://purl.obolibrary.org/obo/HP_0000399	Prelingual sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0011474	Childhood onset sensorineural hearing impairment		A form of sensorineural deafness with either congenital onset or infantile onset, i.e., before the acquisition of speech.
http://purl.obolibrary.org/obo/HP_0000400	Macrotia	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Median longitudinal ear length greater than two standard deviations above the mean and median ear width greater than two standard deviations above the mean (objective); or, apparent increase in length and width of the pinna (subjective).
http://purl.obolibrary.org/obo/HP_0000402	Stenosis of the external auditory canal	http://purl.obolibrary.org/obo/HP_0000372	Abnormal auditory canal morphology		An abnormal narrowing of the external auditory canal.
http://purl.obolibrary.org/obo/HP_0000403	Recurrent otitis media	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		Increased susceptibility to otitis media, as manifested by recurrent episodes of otitis media.
http://purl.obolibrary.org/obo/HP_0000408	Progressive sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		A progressive form of sensorineural hearing impairment.
http://purl.obolibrary.org/obo/HP_0000410	Mixed hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		A type of hearing loss resulting from a combination of conductive hearing impairment and sensorineural hearing impairment.
http://purl.obolibrary.org/obo/HP_0000411	Protruding ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Angle formed by the plane of the ear and the mastoid bone greater than the 97th centile for age (objective); or, outer edge of the helix more than 2 cm from the mastoid at the point of maximum distance (objective).
http://purl.obolibrary.org/obo/HP_0000413	Atresia of the external auditory canal	http://purl.obolibrary.org/obo/HP_0000372	Abnormal auditory canal morphology		Absence or failure to form of the external auditory canal.
http://purl.obolibrary.org/obo/HP_0000414	Bulbous nose	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		Increased volume and globular shape of the anteroinferior aspect of the nose.
http://purl.obolibrary.org/obo/HP_0000415	Abnormal choanae morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Abnormality of the choanae (the posterior nasal apertures).
http://purl.obolibrary.org/obo/HP_0000418	Narrow nasal ridge	http://purl.obolibrary.org/obo/HP_0011119	Abnormal nasal dorsum morphology		Decreased width of the nasal ridge.
http://purl.obolibrary.org/obo/HP_0000419	Abnormal nasal septum morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		An abnormality of the nasal septum.
http://purl.obolibrary.org/obo/HP_0000420	Short nasal septum	http://purl.obolibrary.org/obo/HP_0000419	Abnormal nasal septum morphology		Reduced superior to inferior length of the nasal septum.
http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi.
http://purl.obolibrary.org/obo/HP_0000426	Prominent nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		Anterior positioning of the nasal root in comparison to the usual positioning for age.
http://purl.obolibrary.org/obo/HP_0000429	Abnormal morphology of the nasal alae	http://purl.obolibrary.org/obo/HP_0010938	Abnormal external nose morphology		An abnormality of the Ala of nose.
http://purl.obolibrary.org/obo/HP_0000430	Underdeveloped nasal alae	http://purl.obolibrary.org/obo/HP_0009924	Aplasia/Hypoplasia involving the nose		Thinned, deficient, or excessively arched ala nasi.
http://purl.obolibrary.org/obo/HP_0000431	Wide nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		Increased breadth of the nasal bridge (and with it, the nasal root).
http://purl.obolibrary.org/obo/HP_0000434	Nasal mucosa telangiectasia	http://purl.obolibrary.org/obo/HP_0100579	Mucosal telangiectasiae		Telangiectasia of the nasal mucosa.
http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology	http://purl.obolibrary.org/obo/HP_0010938	Abnormal external nose morphology		An abnormality of the nasal tip.
http://purl.obolibrary.org/obo/HP_0000437	Depressed nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		Decreased distance from the nasal tip to the nasal base.
http://purl.obolibrary.org/obo/HP_0000444	Convex nasal ridge	http://purl.obolibrary.org/obo/HP_0011119	Abnormal nasal dorsum morphology		Nasal ridge curving anteriorly to an imaginary line that connects the nasal root and tip. The nose appears often also prominent, and the columella low.
http://purl.obolibrary.org/obo/HP_0000445	Wide nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Interalar distance more than two standard deviations above the mean for age, i.e., an apparently increased width of the nasal base and alae.
http://purl.obolibrary.org/obo/HP_0000446	Narrow nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		Decreased width of the bony bridge of the nose.
http://purl.obolibrary.org/obo/HP_0000448	Prominent nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Distance between subnasale and pronasale more than two standard deviations above the mean, or alternatively, an apparently increased anterior protrusion of the nasal tip.
http://purl.obolibrary.org/obo/HP_0000452	Choanal stenosis	http://purl.obolibrary.org/obo/HP_0000415	Abnormal choanae morphology		Abnormal narrowing of the choana (the posterior nasal aperture).
http://purl.obolibrary.org/obo/HP_0000453	Choanal atresia	http://purl.obolibrary.org/obo/HP_0000415	Abnormal choanae morphology		Absence or abnormal closure of the choana (the posterior nasal aperture). Most embryologists believe that posterior choanal atresia results from a failure of rupture between the 35th and 38th day of fetal life of the partition which separates the bucconasal or buccopharyngeal membranes. The resultant choanal atresia may be unilateral or bilateral, bony or membranous, complete or incomplete. In over 90 per cent of cases the obstruction is bony, while in the remainder it is membranous. The bony type of atresia is commonly located 1-2 mm. anterior to the posterior edge of the hard palate, and the osseous septum varies in thickness from 1 to 10 mm. In the membranous form of choanal atresia the obstruction usually occurs further posteriorly. In approximately one third of cases the atresia is bilateral.
http://purl.obolibrary.org/obo/HP_0000455	Broad nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		Increase in width of the nasal tip.
http://purl.obolibrary.org/obo/HP_0000456	Bifid nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		A splitting of the nasal tip. Visually assessable vertical indentation, cleft, or depression of the nasal tip.
http://purl.obolibrary.org/obo/HP_0000457	Depressed nasal ridge	http://purl.obolibrary.org/obo/HP_0011119	Abnormal nasal dorsum morphology		Lack of prominence of the nose resulting from a posteriorly-placed nasal ridge.
http://purl.obolibrary.org/obo/HP_0000458	Anosmia	http://purl.obolibrary.org/obo/HP_0004408	Abnormality of the sense of smell		An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.
http://purl.obolibrary.org/obo/HP_0000460	Narrow nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Interalar distance more than 2 SD below the mean for age, or alternatively, an apparently decreased width of the nasal base and alae.
http://purl.obolibrary.org/obo/HP_0000463	Anteverted nares	http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology		Anteriorly-facing nostrils viewed with the head in the Frankfurt horizontal and the eyes of the observer level with the eyes of the subject. This gives the appearance of an upturned nose (upturned nasal tip).
http://purl.obolibrary.org/obo/HP_0000464	Abnormality of the neck	http://purl.obolibrary.org/obo/HP_0000152	Abnormality of head or neck		An abnormality of the neck.
http://purl.obolibrary.org/obo/HP_0000465	Webbed neck	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline.
http://purl.obolibrary.org/obo/HP_0000467	Neck muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Decreased strength of the neck musculature.
http://purl.obolibrary.org/obo/HP_0000468	Increased adipose tissue around the neck	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		An increased amount of subcutaneous fat tissue around the neck.
http://purl.obolibrary.org/obo/HP_0000470	Short neck	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Diminished length of the neck.
http://purl.obolibrary.org/obo/HP_0000471	Gastrointestinal angiodysplasia	http://purl.obolibrary.org/obo/HP_0004296	Abnormal gastrointestinal vascular morphology		Dysplasia affecting the vasculature of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0000472	Long neck	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Increased inferior-superior length of the neck.
http://purl.obolibrary.org/obo/HP_0000473	Torticollis	http://purl.obolibrary.org/obo/HP_0012179	Craniofacial dystonia		Involuntary contractions of the neck musculature resulting in an abnormal posture of or abnormal movements of the head.
http://purl.obolibrary.org/obo/HP_0000474	Thickened nuchal skin fold	http://purl.obolibrary.org/obo/HP_0025667	Fetal neck anomaly		A thickening of the skin thickness in the posterior aspect of the fetal neck. A nuchal fold (NF) measurement is obtained in a transverse section of the fetal head at the level of the cavum septum pellucidum and thalami, angled posteriorly to include the cerebellum. The measurement is taken from the outer edge of the occiput bone to the outer skin limit directly in the midline. An NF measurement greater than 5 mm at 14 to 17+6 weeks of gestation, or 6 mm at 18 to 28 weeks has been associated with a markedly increased risk for Down syndrome.
http://purl.obolibrary.org/obo/HP_0000475	Broad neck	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Increased side-to-side width of the neck.
http://purl.obolibrary.org/obo/HP_0000476	Cystic hygroma	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		A cystic lymphatic lesion of the neck.
http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the eye	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		Any abnormality of the eye, including location, spacing, and intraocular abnormalities.
http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		A structural abnormality of the retina.
http://purl.obolibrary.org/obo/HP_0000480	Retinal coloboma	http://purl.obolibrary.org/obo/HP_0000589	Coloboma		A notch or cleft of the retina or choroid, located vertically below the optic disc.
http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		Any abnormality of the cornea, which is the transparent tissue at the front of the eye that covers the iris, pupil, and anterior chamber.
http://purl.obolibrary.org/obo/HP_0000482	Microcornea	http://purl.obolibrary.org/obo/HP_0001120	Abnormality of corneal size		A congenital abnormality of the cornea in which the cornea and the anterior segment of the eye are smaller than normal. The horizontal diameter of the cornea does not reach 10 mm even in adulthood.
http://purl.obolibrary.org/obo/HP_0000483	Astigmatism	http://purl.obolibrary.org/obo/HP_0100691	Abnormality of the curvature of the cornea		A type of refraction error associated with abnormal curvatures on the anterior and/or posterior surface of the cornea.
http://purl.obolibrary.org/obo/HP_0000484	Hyperopic astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		A form of astigmatism in which one meridian is hyperopic while the one at a right angle to it has no refractive error.
http://purl.obolibrary.org/obo/HP_0000485	Megalocornea	http://purl.obolibrary.org/obo/HP_0001120	Abnormality of corneal size		An enlargement of the cornea with normal clarity and function. Megalocornea is diagnosed with a horizontal corneal diameter of 12 mm or more at birth or 13 mm or more after two years of age.
http://purl.obolibrary.org/obo/HP_0000486	Strabismus	http://purl.obolibrary.org/obo/HP_0000549	Abnormal conjugate eye movement		A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error.
http://purl.obolibrary.org/obo/HP_0000488	Retinopathy	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality.
http://purl.obolibrary.org/obo/HP_0000490	Deeply set eye	http://purl.obolibrary.org/obo/HP_0100886	Abnormality of globe location		An eye that is more deeply recessed into the plane of the face than is typical.
http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology	http://purl.obolibrary.org/obo/HP_0030669	Abnormal ocular adnexa morphology		An abnormality of the eyelids.
http://purl.obolibrary.org/obo/HP_0000493	Abnormal foveal morphology	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		An abnormality of the fovea centralis, the central area of the macula that mediates central, high resolution vision and contains the largest concentration of cone cells in the retina.
http://purl.obolibrary.org/obo/HP_0000494	Downslanted palpebral fissures	http://purl.obolibrary.org/obo/HP_0200006	Slanting of the palpebral fissure		The palpebral fissure inclination is more than two standard deviations below the mean.
http://purl.obolibrary.org/obo/HP_0000495	Recurrent corneal erosions	http://purl.obolibrary.org/obo/HP_0200020	Corneal erosion		The presence of recurrent corneal epithelial erosions. Although most corneal epithelial defects heal quickly, some may show recurrent ulcerations.
http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		An abnormality in voluntary or involuntary eye movements or their control.
http://purl.obolibrary.org/obo/HP_0000498	Blepharitis	http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye		Inflammation of the eyelids.
http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		An abnormality of the eyelashes.
http://purl.obolibrary.org/obo/HP_0000501	Glaucoma	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure.
http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology	http://purl.obolibrary.org/obo/HP_0030669	Abnormal ocular adnexa morphology		An abnormality of the conjunctiva.
http://purl.obolibrary.org/obo/HP_0000503	Tortuosity of conjunctival vessels	http://purl.obolibrary.org/obo/HP_0008054	Abnormal morphology of the conjunctival vasculature		The presence of an increased number of twists and turns of the conjunctival blood vessels.
http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		Abnormality of eyesight (visual perception).
http://purl.obolibrary.org/obo/HP_0000505	Visual impairment	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery.
http://purl.obolibrary.org/obo/HP_0000506	Telecanthus	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Distance between the inner canthi more than two standard deviations above the mean (objective); or, apparently increased distance between the inner canthi.
http://purl.obolibrary.org/obo/HP_0000510	Rod-cone dystrophy	http://purl.obolibrary.org/obo/HP_0000556	Retinal dystrophy		An inherited retinal disease subtype in which the rod photoreceptors appear to be more severely affected than the cone photoreceptors. Typical presentation is with nyctalopia (due to rod dysfunction) followed by loss of mid-peripheral field of vision, which gradually extends and leaves many patients with a small central island of vision due to the preservation of macular cones.
http://purl.obolibrary.org/obo/HP_0000511	Vertical supranuclear gaze palsy	http://purl.obolibrary.org/obo/HP_0000605	Supranuclear gaze palsy		A supranuclear gaze palsy is an inability to look in a vertical direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal.
http://purl.obolibrary.org/obo/HP_0000512	Abnormal electroretinogram	http://purl.obolibrary.org/obo/HP_0030453	Abnormal visual electrophysiology		Any abnormality of the electrical responses of various cell types in the retina as measured by electroretinography.
http://purl.obolibrary.org/obo/HP_0000514	Slow saccadic eye movements	http://purl.obolibrary.org/obo/HP_0000570	Abnormal saccadic eye movements		An abnormally slow velocity of the saccadic eye movements.
http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		An abnormality of the lens.
http://purl.obolibrary.org/obo/HP_0000518	Cataract	http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology		A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.
http://purl.obolibrary.org/obo/HP_0000519	Developmental cataract	http://purl.obolibrary.org/obo/HP_0007700	Ocular anterior segment dysgenesis		A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens.
http://purl.obolibrary.org/obo/HP_0000520	Proptosis	http://purl.obolibrary.org/obo/HP_0100886	Abnormality of globe location		An eye that is protruding anterior to the plane of the face to a greater extent than is typical.
http://purl.obolibrary.org/obo/HP_0000522	Alacrima	http://purl.obolibrary.org/obo/HP_0000633	Decreased lacrimation		Absence of tear secretion.
http://purl.obolibrary.org/obo/HP_0000523	Subcapsular cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A cataract that affects the region of the lens directly beneath the capsule of the lens.
http://purl.obolibrary.org/obo/HP_0000524	Conjunctival telangiectasia	http://purl.obolibrary.org/obo/HP_0100579	Mucosal telangiectasiae		The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the conjunctiva.
http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		An abnormality of the iris, which is the pigmented muscular tissue between the cornea and the lens, that is perforated by an opening called the pupil.
http://purl.obolibrary.org/obo/HP_0000527	Long eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective).
http://purl.obolibrary.org/obo/HP_0000528	Anophthalmia	http://purl.obolibrary.org/obo/HP_0100887	Abnormality of globe size		Absence of the globe or eyeball.
http://purl.obolibrary.org/obo/HP_0000529	Progressive visual loss	http://purl.obolibrary.org/obo/HP_0000572	Visual loss		A reduction of previously attained ability to see.
http://purl.obolibrary.org/obo/HP_0000532	Abnormal chorioretinal morphology	http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology		An abnormality of the choroid and retina.
http://purl.obolibrary.org/obo/HP_0000533	Chorioretinal atrophy	http://purl.obolibrary.org/obo/HP_0000532	Abnormal chorioretinal morphology		Atrophy (wasting) of the choroid and retinal layers of the fundus.
http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology	http://purl.obolibrary.org/obo/HP_0030669	Abnormal ocular adnexa morphology		An abnormality of the eyebrow.
http://purl.obolibrary.org/obo/HP_0000537	Epicanthus inversus	http://purl.obolibrary.org/obo/HP_0000286	Epicanthus		A fold of skin starting at or just below the medial aspect of the lower lid and arching upward to cover, extend in front of and lateral to the medial canthus.
http://purl.obolibrary.org/obo/HP_0000538	Pseudopapilledema	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		Apparent optic disc swelling in the absence of increased intracranial pressure.
http://purl.obolibrary.org/obo/HP_0000539	Abnormality of refraction	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		An abnormality in the process of focusing of light by the eye in order to produce a sharp image on the retina.
http://purl.obolibrary.org/obo/HP_0000540	Hypermetropia	http://purl.obolibrary.org/obo/HP_0000539	Abnormality of refraction		An abnormality of refraction characterized by the ability to see objects in the distance clearly, while objects nearby appear blurry.
http://purl.obolibrary.org/obo/HP_0000541	Retinal detachment	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Separation of the inner layers of the retina (neural retina) from the pigment epithelium.
http://purl.obolibrary.org/obo/HP_0000542	Impaired ocular adduction	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Reduced ability to move the eye in the direction of the nose.
http://purl.obolibrary.org/obo/HP_0000543	Optic disc pallor	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		A pale yellow discoloration of the optic disc (the area of the optic nerve head in the retina). The optic disc normally has a pinkish hue with a central yellowish depression.
http://purl.obolibrary.org/obo/HP_0000544	External ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000602	Ophthalmoplegia		Paralysis of the external ocular muscles.
http://purl.obolibrary.org/obo/HP_0000545	Myopia	http://purl.obolibrary.org/obo/HP_0000539	Abnormality of refraction		An abnormality of refraction characterized by the ability to see objects nearby clearly, while objects in the distance appear blurry.
http://purl.obolibrary.org/obo/HP_0000546	Retinal degeneration	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		A nonspecific term denoting progressive loss of the retinal pigment epithelium (RPE) and/or neurosensory retinal cells.
http://purl.obolibrary.org/obo/HP_0000549	Abnormal conjugate eye movement	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object.
http://purl.obolibrary.org/obo/HP_0000550	Undetectable electroretinogram	http://purl.obolibrary.org/obo/HP_0000512	Abnormal electroretinogram		Lack of any response to stimulation upon electroretinography.
http://purl.obolibrary.org/obo/HP_0000551	Color vision defect	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		An anomaly in the ability to discriminate between or recognize colors.
http://purl.obolibrary.org/obo/HP_0000552	Tritanomaly	http://purl.obolibrary.org/obo/HP_0011519	Anomalous trichromacy		Difficulty distinguishing between yellow and blue, possible related to dysfunction of the S photopigment.
http://purl.obolibrary.org/obo/HP_0000553	Abnormal uvea morphology	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		An abnormality of the uvea, the vascular layer of the eyeball.
http://purl.obolibrary.org/obo/HP_0000555	Leukocoria	http://purl.obolibrary.org/obo/HP_0000615	Abnormal pupil morphology		An abnormal white reflection from the pupil rather than the usual black reflection.
http://purl.obolibrary.org/obo/HP_0000557	Buphthalmos	http://purl.obolibrary.org/obo/HP_0001090	Abnormally large globe		Diffusely large eye (with megalocornea) associated with glaucoma.
http://purl.obolibrary.org/obo/HP_0000558	Rieger anomaly	http://purl.obolibrary.org/obo/HP_0007676	Hypoplasia of the iris		A congenital malformation of the anterior segment characterized by iridicorneal malformation, glaucoma, iris stroma hypoplasia, posterior embryotoxon, and corneal opacities.
http://purl.obolibrary.org/obo/HP_0000561	Absent eyelashes	http://purl.obolibrary.org/obo/HP_0200102	Sparse or absent eyelashes		Lack of eyelashes.
http://purl.obolibrary.org/obo/HP_0000563	Keratoconus	http://purl.obolibrary.org/obo/HP_0100692	Increased corneal curvature		A cone-shaped deformity of the cornea characterized by the presence of corneal distortion secondary to thinning of the apex.
http://purl.obolibrary.org/obo/HP_0000564	Lacrimal duct atresia	http://purl.obolibrary.org/obo/HP_0011481	Abnormal lacrimal duct morphology		A developmental disorder of the lacrimal drainage system that most often affects the lacrimal ostium and resulting in non-opening of the nasolacrimal duct. It usually results from a non-canalization of the nasolacrimal duct.
http://purl.obolibrary.org/obo/HP_0000565	Esotropia	http://purl.obolibrary.org/obo/HP_0032012	Heterotropia		A form of strabismus with one or both eyes turned inward ('crossed') to a relatively severe degree, usually defined as 10 diopters or more.
http://purl.obolibrary.org/obo/HP_0000567	Chorioretinal coloboma	http://purl.obolibrary.org/obo/HP_0000589	Coloboma		Absence of a region of the retina, retinal pigment epithelium, and choroid.
http://purl.obolibrary.org/obo/HP_0000568	Microphthalmia	http://purl.obolibrary.org/obo/HP_0100887	Abnormality of globe size		A developmental anomaly characterized by abnormal smallness of one or both eyes.
http://purl.obolibrary.org/obo/HP_0000570	Abnormal saccadic eye movements	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		An abnormality of eye movement characterized by impairment of fast (saccadic) eye movements.
http://purl.obolibrary.org/obo/HP_0000571	Hypometric saccades	http://purl.obolibrary.org/obo/HP_0000570	Abnormal saccadic eye movements		Saccadic undershoot, i.e., a saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.
http://purl.obolibrary.org/obo/HP_0000573	Retinal hemorrhage	http://purl.obolibrary.org/obo/HP_0031803	Fundus hemorrhage		Bleeding located within the retina. Retinal hemorrhages range from the smallest dot and blot hemorrhage to massive sub-hyaloid hemorrhage.
http://purl.obolibrary.org/obo/HP_0000574	Thick eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		Increased density/number and/or increased diameter of eyebrow hairs.
http://purl.obolibrary.org/obo/HP_0000575	Scotoma	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		A regional and pathological increase of the light detection threshold in any region of the visual field surrounded by a field of normal or relatively well-preserved vision.
http://purl.obolibrary.org/obo/HP_0000576	Centrocecal scotoma	http://purl.obolibrary.org/obo/HP_0000575	Scotoma		A scotoma (area of diminished vision within the visual field) located between the central point of fixation and the blind spot with a roughly horizontal oval shape.
http://purl.obolibrary.org/obo/HP_0000577	Exotropia	http://purl.obolibrary.org/obo/HP_0032012	Heterotropia		A form of strabismus with one or both eyes deviated outward.
http://purl.obolibrary.org/obo/HP_0000579	Nasolacrimal duct obstruction	http://purl.obolibrary.org/obo/HP_0011481	Abnormal lacrimal duct morphology		Blockage of the lacrimal duct.
http://purl.obolibrary.org/obo/HP_0000580	Pigmentary retinopathy	http://purl.obolibrary.org/obo/HP_0007703	Abnormal retinal pigmentation		An abnormality of the retina characterized by pigment deposition. It is typically associated with migration and proliferation of macrophages or retinal pigment epithelial cells into the retina; melanin from these cells causes the pigmentary changes. Pigmentary retinopathy is a common final pathway of many retinal conditions and is often associated with visual loss.
http://purl.obolibrary.org/obo/HP_0000581	Blepharophimosis	http://purl.obolibrary.org/obo/HP_0200007	Abnormal size of the palpebral fissures		A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures.
http://purl.obolibrary.org/obo/HP_0000582	Upslanted palpebral fissure	http://purl.obolibrary.org/obo/HP_0200006	Slanting of the palpebral fissure		The palpebral fissure inclination is more than two standard deviations above the mean for age (objective); or, the inclination of the palpebral fissure is greater than typical for age.
http://purl.obolibrary.org/obo/HP_0000585	Band keratopathy	http://purl.obolibrary.org/obo/HP_0011493	Central opacification of the cornea		An abnormality of the cornea characterized by the deposition of calcium in a band across the central cornea, leading to decreased vision, foreign body sensation, and ocular irritation.
http://purl.obolibrary.org/obo/HP_0000586	Shallow orbits	http://purl.obolibrary.org/obo/HP_3000030	Abnormal morphology of bony orbit of skull		Reduced depth of the orbits associated with prominent-appearing ocular globes.
http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Abnormality of the optic nerve.
http://purl.obolibrary.org/obo/HP_0000588	Optic disc coloboma	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		A cleft of the optic nerve that extends inferiorly.
http://purl.obolibrary.org/obo/HP_0000589	Coloboma	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa.
http://purl.obolibrary.org/obo/HP_0000590	Progressive external ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000544	External ophthalmoplegia		Initial bilateral ptosis followed by limitation of eye movements in all directions and slowing of saccades.
http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		An abnormality of the sclera.
http://purl.obolibrary.org/obo/HP_0000592	Blue sclerae	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		An abnormal bluish coloration of the sclera.
http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		Abnormality of the anterior chamber, which is the space in the eye that is behind the cornea and in front of the iris.
http://purl.obolibrary.org/obo/HP_0000594	Shallow anterior chamber	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		Reduced depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is decreased.
http://purl.obolibrary.org/obo/HP_0000597	Ophthalmoparesis	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Ophthalmoplegia is a paralysis or weakness of one or more of the muscles that control eye movement.
http://purl.obolibrary.org/obo/HP_0000598	Abnormality of the ear	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the ear.
http://purl.obolibrary.org/obo/HP_0000599	Abnormality of the frontal hairline	http://purl.obolibrary.org/obo/HP_0009553	Abnormality of the hairline		An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not.
http://purl.obolibrary.org/obo/HP_0000600	Abnormality of the pharynx	http://purl.obolibrary.org/obo/HP_0002087	Abnormality of the upper respiratory tract		An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly.
http://purl.obolibrary.org/obo/HP_0000601	Hypotelorism	http://purl.obolibrary.org/obo/HP_0100886	Abnormality of globe location		Interpupillary distance less than 2 SD below the mean (alternatively, the appearance of an decreased interpupillary distance or closely spaced eyes).
http://purl.obolibrary.org/obo/HP_0000602	Ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000597	Ophthalmoparesis		Paralysis of one or more extraocular muscles that are responsible for eye movements.
http://purl.obolibrary.org/obo/HP_0000603	Central scotoma	http://purl.obolibrary.org/obo/HP_0000575	Scotoma		An area of depressed vision located at the point of fixation and that interferes with central vision.
http://purl.obolibrary.org/obo/HP_0000605	Supranuclear gaze palsy	http://purl.obolibrary.org/obo/HP_0000549	Abnormal conjugate eye movement		A supranuclear gaze palsy is an inability to look in a particular direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal.
http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		An abnormality of the region situated around the orbit of the eye.
http://purl.obolibrary.org/obo/HP_0000609	Optic nerve hypoplasia	http://purl.obolibrary.org/obo/HP_0008058	Aplasia/Hypoplasia of the optic nerve		Underdevelopment of the optic nerve.
http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Any structural abnormality of the choroid (the posterior part of the uvea, the middle tunic of the eye, consisting mainly of blood vessels).
http://purl.obolibrary.org/obo/HP_0000612	Iris coloboma	http://purl.obolibrary.org/obo/HP_0000589	Coloboma		A coloboma of the iris.
http://purl.obolibrary.org/obo/HP_0000614	Abnormal nasolacrimal system morphology	http://purl.obolibrary.org/obo/HP_0030669	Abnormal ocular adnexa morphology		An abnormality of the nasolacrimal drainage system, which serves as a conduit for tear flow from the external eye to the nasal cavity.
http://purl.obolibrary.org/obo/HP_0000615	Abnormal pupil morphology	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		An abnormality of the pupil.
http://purl.obolibrary.org/obo/HP_0000616	Miosis	http://purl.obolibrary.org/obo/HP_0007686	Abnormal pupillary function		Abnormal (non-physiological) constriction of the pupil.
http://purl.obolibrary.org/obo/HP_0000617	Abnormality of ocular smooth pursuit	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		An abnormality of eye movement characterized by impaired smooth-pursuit eye movements.
http://purl.obolibrary.org/obo/HP_0000619	Impaired convergence	http://purl.obolibrary.org/obo/HP_0000549	Abnormal conjugate eye movement		Reduced ability to turn the eyes inward in order to focus on a nearby object.
http://purl.obolibrary.org/obo/HP_0000620	Dacryocystitis	http://purl.obolibrary.org/obo/HP_0000614	Abnormal nasolacrimal system morphology		Inflammation of the nasolacrimal sac.
http://purl.obolibrary.org/obo/HP_0000621	Entropion	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		An abnormal inversion (turning inward) of the eyelid (usually the lower) towards the globe. Entropion is usually acquired as a result of involutional or cicatricial processes but may occasionally be congenital.
http://purl.obolibrary.org/obo/HP_0000623	Supranuclear ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000602	Ophthalmoplegia		A vertical gaze palsy with inability to direct the gaze of the eyes downwards.
http://purl.obolibrary.org/obo/HP_0000625	Eyelid coloboma	http://purl.obolibrary.org/obo/HP_0011226	Aplasia/Hypoplasia of the eyelid		A short discontinuity of the margin of the lower or upper eyelid.
http://purl.obolibrary.org/obo/HP_0000627	Posterior embryotoxon	http://purl.obolibrary.org/obo/HP_0008048	Abnormal line of Schwalbe morphology		A posterior embryotoxon is the presence of a prominent and anteriorly displaced line of Schwalbe.
http://purl.obolibrary.org/obo/HP_0000629	Periorbital fullness	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Increase in periorbital soft tissue.
http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology	http://purl.obolibrary.org/obo/HP_3000036	Abnormal head blood vessel morphology		Any deviation from the normal structure of the retinal artery or arterioles.
http://purl.obolibrary.org/obo/HP_0000631	Retinal arterial tortuosity	http://purl.obolibrary.org/obo/HP_0012841	Retinal vascular tortuosity		The presence of an increased number of twists and turns of the retinal artery.
http://purl.obolibrary.org/obo/HP_0000632	Lacrimation abnormality	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		Abnormality of tear production.
http://purl.obolibrary.org/obo/HP_0000633	Decreased lacrimation	http://purl.obolibrary.org/obo/HP_0000632	Lacrimation abnormality		Abnormally decreased lacrimation, that is, reduced tear production.
http://purl.obolibrary.org/obo/HP_0000634	Impaired ocular abduction	http://purl.obolibrary.org/obo/HP_0011347	Abnormality of ocular abduction		An impaired ability of the eye to move in the outward direction (towards the side of the head).
http://purl.obolibrary.org/obo/HP_0000635	Blue irides	http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation		A markedly blue coloration of the iris.
http://purl.obolibrary.org/obo/HP_0000636	Upper eyelid coloboma	http://purl.obolibrary.org/obo/HP_0000625	Eyelid coloboma		A short discontinuity of the margin of the upper eyelid.
http://purl.obolibrary.org/obo/HP_0000637	Long palpebral fissure	http://purl.obolibrary.org/obo/HP_0200007	Abnormal size of the palpebral fissures		Distance between medial and lateral canthi is more than two standard deviations above the mean for age (objective); or, apparently increased length of the palpebral fissures.
http://purl.obolibrary.org/obo/HP_0000639	Nystagmus	http://purl.obolibrary.org/obo/HP_0012547	Abnormal involuntary eye movements		Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms.
http://purl.obolibrary.org/obo/HP_0000640	Gaze-evoked nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		Nystagmus made apparent by looking to the right or to the left.
http://purl.obolibrary.org/obo/HP_0000641	Dysmetric saccades	http://purl.obolibrary.org/obo/HP_0000570	Abnormal saccadic eye movements		The controller signal for saccadic eye movements has two components: the pulse that moves the eye rapidly from one point to the next, and the step that holds the eye in the new position. When both the pulse and the step are not the correct size, a dysmetric refixation eye movement results.
http://purl.obolibrary.org/obo/HP_0000642	Red-green dyschromatopsia	http://purl.obolibrary.org/obo/HP_0007641	Dyschromatopsia		Difficulty with discriminating red and green hues.
http://purl.obolibrary.org/obo/HP_0000643	Blepharospasm	http://purl.obolibrary.org/obo/HP_0031879	Abnormal eyelid physiology		A focal dystonia that affects the muscles of the eyelids and brow, associated with involuntary recurrent spasm of both eyelids.
http://purl.obolibrary.org/obo/HP_0000646	Amblyopia	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways.
http://purl.obolibrary.org/obo/HP_0000647	Sclerocornea	http://purl.obolibrary.org/obo/HP_0007957	Corneal opacity		A congenital anomaly in which a part or the whole of the cornea acquires the characteristics of sclera, resulting in clouding of the cornea.
http://purl.obolibrary.org/obo/HP_0000649	Abnormality of visual evoked potentials	http://purl.obolibrary.org/obo/HP_0430106	Abnormal brain-evoked potentials		An anomaly of visually evoked potentials (VEP), which are electrical potentials, initiated by brief visual stimuli, which are recorded from the scalp overlying the visual cortex.
http://purl.obolibrary.org/obo/HP_0000652	Lower eyelid coloboma	http://purl.obolibrary.org/obo/HP_0000625	Eyelid coloboma		A short discontinuity of the margin of the lower eyelid.
http://purl.obolibrary.org/obo/HP_0000653	Sparse eyelashes	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Decreased density/number of eyelashes.
http://purl.obolibrary.org/obo/HP_0000654	Decreased light- and dark-adapted electroretinogram amplitude	http://purl.obolibrary.org/obo/HP_0008323	Abnormal light- and dark-adapted electroretinogram		Decreased amplitude of eletrical response upon electroretinography.
http://purl.obolibrary.org/obo/HP_0000656	Ectropion	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		An outward turning (eversion) or rotation of the eyelid margin.
http://purl.obolibrary.org/obo/HP_0000657	Oculomotor apraxia	http://purl.obolibrary.org/obo/HP_0002186	Apraxia		Ocular motor apraxia is a deficiency in voluntary, horizontal, lateral, fast eye movements (saccades) with retention of slow pursuit movements. The inability to follow objects visually is often compensated by head movements. There may be decreased smooth pursuit, and cancelation of the vestibulo-ocular reflex.
http://purl.obolibrary.org/obo/HP_0000659	Peters anomaly	http://purl.obolibrary.org/obo/HP_0007700	Ocular anterior segment dysgenesis		A form of anterior segment dysgenesis in which abnormal cleavage of the anterior chamber occurs. Peters anomaly is characterized by central, paracentral, or complete corneal opacity.
http://purl.obolibrary.org/obo/HP_0000660	Lipemia retinalis	http://purl.obolibrary.org/obo/HP_0030603	Abnormal optical coherence tomography		A creamy appearance of the retinal blood vessels that occurs when the concentration of lipids in the blood is extremely increased, with pale pink to milky white retinal vessels and altered pale reflexes from choroidal vasculature.
http://purl.obolibrary.org/obo/HP_0000662	Nyctalopia	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Inability to see well at night or in poor light.
http://purl.obolibrary.org/obo/HP_0000664	Synophrys	http://purl.obolibrary.org/obo/HP_0002219	Facial hypertrichosis		Meeting of the medial eyebrows in the midline.
http://purl.obolibrary.org/obo/HP_0000666	Horizontal nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		Nystagmus consisting of horizontal to-and-fro eye movements.
http://purl.obolibrary.org/obo/HP_0000667	Phthisis bulbi	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		Atrophy of the eyeball with blindness and decreased intraocular pressure due to end-stage intraocular disease.
http://purl.obolibrary.org/obo/HP_0000670	Carious teeth	http://purl.obolibrary.org/obo/HP_0011061	Abnormality of dental structure		Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has been used to describe the presence of more than expected dental caries.
http://purl.obolibrary.org/obo/HP_0000674	Anodontia	http://purl.obolibrary.org/obo/HP_0009804	Tooth agenesis		The absence of all teeth from the normal series by a failure to develop.
http://purl.obolibrary.org/obo/HP_0000675	Macrodontia of permanent maxillary central incisor	http://purl.obolibrary.org/obo/HP_0011081	Incisor macrodontia		Increased size of the maxillary central secondary incisor tooth.
http://purl.obolibrary.org/obo/HP_0000676	Abnormality of the incisor	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		An abnormality of the Incisor tooth.
http://purl.obolibrary.org/obo/HP_0000677	Oligodontia	http://purl.obolibrary.org/obo/HP_0009804	Tooth agenesis		The absence of six or more teeth from the normal series by a failure to develop.
http://purl.obolibrary.org/obo/HP_0000678	Dental crowding	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Changes in alignment of teeth in the dental arch
http://purl.obolibrary.org/obo/HP_0000679	Taurodontia	http://purl.obolibrary.org/obo/HP_0011071	Abnormal permanent molar morphology		Increased volume of dental pulp of permanent molar characterized by a crown body-root ratio equal or larger than 1:1 or an elongated pulp chambers and apical displacement of the bifurcation or trifurcation of the roots.
http://purl.obolibrary.org/obo/HP_0000680	Delayed eruption of primary teeth	http://purl.obolibrary.org/obo/HP_0006481	Abnormal primary tooth morphology		Delayed tooth eruption affecting the primary dentition.
http://purl.obolibrary.org/obo/HP_0000682	Abnormal dental enamel morphology	http://purl.obolibrary.org/obo/HP_3000050	Abnormal odontoid tissue morphology		An abnormality of the dental enamel.
http://purl.obolibrary.org/obo/HP_0000683	Grayish enamel	http://purl.obolibrary.org/obo/HP_0011073	Abnormality of dental color		A gray discoloration of the dental enamel.
http://purl.obolibrary.org/obo/HP_0000684	Delayed eruption of teeth	http://purl.obolibrary.org/obo/HP_0006292	Abnormality of dental eruption		Delayed tooth eruption, which can be defined as tooth eruption more than 2 SD beyond the mean eruption age.
http://purl.obolibrary.org/obo/HP_0000685	Hypoplasia of teeth	http://purl.obolibrary.org/obo/HP_0011061	Abnormality of dental structure		Developmental hypoplasia of teeth.
http://purl.obolibrary.org/obo/HP_0000687	Widely spaced teeth	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Increased spaces (diastemata) between most of the teeth in the same dental arch.
http://purl.obolibrary.org/obo/HP_0000689	Dental malocclusion	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns.
http://purl.obolibrary.org/obo/HP_0000690	Agenesis of maxillary lateral incisor	http://purl.obolibrary.org/obo/HP_0200160	Agenesis of maxillary incisor		Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor and maxillary lateral secondary incisor.
http://purl.obolibrary.org/obo/HP_0000691	Microdontia	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		Decreased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD below mean. Alternatively, an apparently decreased maximum width of tooth.
http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		Abnormal alignment, positioning, or spacing of the teeth, i.e., misaligned teeth.
http://purl.obolibrary.org/obo/HP_0000694	Odontodysplasia	http://purl.obolibrary.org/obo/HP_0000703	Dentinogenesis imperfecta		The diagnosis odontodysplasia requires clinical and radiological exams, in which unusually large pulp chambers and large pulp room chambers with thin enamel and dentin are visible. It may affect either a single tooth or several teeth. The term regional odontodysplasia is used if several teeth are affected. It affects the deciduous and permanent dentitions in the maxilla, the mandible or both, although the maxilla is more frequently involved. A type of dental dysplasia occurring in dentinogenesis imperfecta in which the pulp chambers are enlarged and there is a reduced amount of coronal dentin.
http://purl.obolibrary.org/obo/HP_0000695	Natal tooth	http://purl.obolibrary.org/obo/HP_0006288	Advanced eruption of teeth		A tooth present at birth or erupting within the first month of life.
http://purl.obolibrary.org/obo/HP_0000696	Delayed eruption of permanent teeth	http://purl.obolibrary.org/obo/HP_0000684	Delayed eruption of teeth		Delayed tooth eruption affecting the secondary dentition.
http://purl.obolibrary.org/obo/HP_0000698	Conical tooth	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		An abnormal conical form of the teeth, that is, a tooth whose sides converge or taper together incisally.
http://purl.obolibrary.org/obo/HP_0000699	Diastema	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Increased space between two adjacent teeth in the same dental arch.
http://purl.obolibrary.org/obo/HP_0000700	Periapical bone loss	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		Radiolucency (reflecting a reduction in the bony substance) around the apex (the tip of the dental root).
http://purl.obolibrary.org/obo/HP_0000703	Dentinogenesis imperfecta	http://purl.obolibrary.org/obo/HP_3000050	Abnormal odontoid tissue morphology		Developmental dysplasia of dentin.
http://purl.obolibrary.org/obo/HP_0000704	Periodontitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of the periodontium.
http://purl.obolibrary.org/obo/HP_0000705	Amelogenesis imperfecta	http://purl.obolibrary.org/obo/HP_0000682	Abnormal dental enamel morphology		A developmental dysplasia of the dental enamel.
http://purl.obolibrary.org/obo/HP_0000706	Eruption failure	http://purl.obolibrary.org/obo/HP_0006292	Abnormality of dental eruption		A tooth which does not erupt within the teeth eruption timeline and after the loss of eruption potential.
http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		Atypical behavior is an abnormality in a person's actions that can be controlled or modulated by the will of the individual. While abnormal behaviors can be difficult to control, they are distinct from other abnormal actions that cannot be affected by the individual's will.
http://purl.obolibrary.org/obo/HP_0000709	Psychosis	http://purl.obolibrary.org/obo/HP_5200430	Abnormal psychotic pattern		A condition characterized by changes in personality and thought patterns, often accompanied by hallucinations and delusional beliefs, is known as psychosis.
http://purl.obolibrary.org/obo/HP_0000710	Hyperorality	http://purl.obolibrary.org/obo/HP_5200065	Tactile sensory seeking		Hyperorality is a condition characterized by an excessive preoccupation with oral sensations and behaviors, such as chewing, sucking, biting, swallowing, and excessive mouthing of objects.
http://purl.obolibrary.org/obo/HP_0000711	Restlessness	http://purl.obolibrary.org/obo/HP_5200263	Abnormally increased volition		A state of unease is characterized by diffuse motor activity or motion, which is subject to limited control, nonproductive, or disorganized behavior.
http://purl.obolibrary.org/obo/HP_0000712	Emotional lability	http://purl.obolibrary.org/obo/HP_0020007	Abnormal affect regulation		Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or disproportionate to events and circumstances.
http://purl.obolibrary.org/obo/HP_0000716	Depression	http://purl.obolibrary.org/obo/HP_0100851	Abnormal emotional state		Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.
http://purl.obolibrary.org/obo/HP_0000717	Autism	http://purl.obolibrary.org/obo/HP_0000729	Autistic behavior		Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. Autism begins in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual (DSM-IV).
http://purl.obolibrary.org/obo/HP_0000718	Aggressive behavior	http://purl.obolibrary.org/obo/HP_0000734	Disinhibition		Behavior or an act aimed at harming a person, animal, or physical property (e.g., acts of physical violence; shouting, swearing, and using harsh language; slashing someone's tires).
http://purl.obolibrary.org/obo/HP_0000719	Inappropriate behavior	http://purl.obolibrary.org/obo/HP_5200029	Social disinhibition		An explicit or perceived action, demonstration, conduct, or language (verbal and written) that is contrary to generally accepted norms, rules, procedures, or unacceptable within the context in which it is carried out. Inappropriate behaviors could take place in a sexual or social context and could be aggressive, violent, impulsive, intimidating, or threatening in nature.
http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		Behavior that consists of repetitive acts, characterized by the feeling that one "has to" perform them, while being aware that these acts are not in line with one's overall goal.
http://purl.obolibrary.org/obo/HP_0000723	Restrictive behavior	http://purl.obolibrary.org/obo/HP_0031432	Restricted or repetitive behaviors or interests		Behavior characterized by an abnormal limitation to a few interests and activities.
http://purl.obolibrary.org/obo/HP_0000725	Psychotic episodes	http://purl.obolibrary.org/obo/HP_5200430	Abnormal psychotic pattern		Periods of time during which an individual experiences significant disturbances in their thoughts, perceptions, emotions, and behavior, resulting in a loss of touch with reality. These episodes are hallmark features of psychotic disorders such as schizophrenia, schizoaffective disorder, and certain forms of bipolar disorder.
http://purl.obolibrary.org/obo/HP_0000726	Dementia	http://purl.obolibrary.org/obo/HP_0001268	Mental deterioration		A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior.
http://purl.obolibrary.org/obo/HP_0000728	Reduced ability to form peer relationships	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		Difficulty to establish relations with others in a comparable social group (peers) that may be manifested in pehnomena such as not being able to initiative a conversation, understand social cues, or to discuss shared interests. This feature is associated with poor integration within a community or group.
http://purl.obolibrary.org/obo/HP_0000729	Autistic behavior	http://purl.obolibrary.org/obo/HP_0025783	Diagnostic behavioral phenotype		Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior.
http://purl.obolibrary.org/obo/HP_0000732	Inflexible adherence to routines	http://purl.obolibrary.org/obo/HP_5200130	Insistence on sameness		A need to strictly adhere to repetitive routines or patterns of behavior which are created by the environment. One becomes upset or distressed when their routines are disrupted or altered.
http://purl.obolibrary.org/obo/HP_0000733	Motor stereotypy	http://purl.obolibrary.org/obo/HP_0031432	Restricted or repetitive behaviors or interests		Use of the same abnormal action in response to certain triggers or at random. They may be used as a way to regulate one's internal state but must otherwise have no apparent functional purpose.
http://purl.obolibrary.org/obo/HP_0000734	Disinhibition	http://purl.obolibrary.org/obo/HP_5200263	Abnormally increased volition		Reduced ability to control, or a failure to resist a temptation, urge, or impulse. Examples include disregard for social conventions, general impulsivity, and poor risk assessment.
http://purl.obolibrary.org/obo/HP_0000736	Short attention span	http://purl.obolibrary.org/obo/HP_5200044	Reduced attention regulation		Reduced attention span characterized by distractibility and impulsivity.
http://purl.obolibrary.org/obo/HP_0000738	Hallucinations	http://purl.obolibrary.org/obo/HP_5200423	Abnormal experience of reality		Perceptions in a conscious and awake state that, in the absence of external stimuli, have qualities of real perception. These perceptions are vivid, substantial, and located in external objective space.
http://purl.obolibrary.org/obo/HP_0000740	Episodic paroxysmal anxiety	http://purl.obolibrary.org/obo/HP_0000739	Anxiety		Recurrent attacks of severe anxiety, which occur without restriction to any particular situation or set of circumstances, are therefore unpredictable.
http://purl.obolibrary.org/obo/HP_0000742	Self-mutilation	http://purl.obolibrary.org/obo/HP_0100716	Self-injurious behavior		Deliberate harm to one's body resulting in tissue damage, without a conscious intent to die.
http://purl.obolibrary.org/obo/HP_0000743	Frontal release signs	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Primitive reflexes traditionally held to be a sign of disorders that affect the frontal lobes.
http://purl.obolibrary.org/obo/HP_0000744	Low frustration tolerance	http://purl.obolibrary.org/obo/HP_0020007	Abnormal affect regulation		The feeling of frustration can be defined as an emotional reaction that occurs when a desired goal is not achieved. Frustration intolerance is defined as an age-inappropriate response to frustration, characterized by crying or temper tantrums in children, or aggressive or other maladaptive behaviors.
http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition	http://purl.obolibrary.org/obo/HP_0025780	Abnormal volitional state		A reduction in willful and motivated goal-directed behavior that is considered the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action.
http://purl.obolibrary.org/obo/HP_0000746	Delusion	http://purl.obolibrary.org/obo/HP_0025779	Disorder of thought content		A delusion is a fixed false belief held despite evidence to the contrary. The term delusion broadly encompasses all false judgments that possess the following external characteristics to a significant, albeit unspecified, extent: (1) they are held with an exceptional level of conviction, accompanied by an unparalleled subjective certainty; (2) there is an inability to consider alternative experiences or compelling counter-arguments; (3) the content of the belief is impossible.
http://purl.obolibrary.org/obo/HP_0000748	Inappropriate laughter	http://purl.obolibrary.org/obo/HP_5200029	Social disinhibition		Laughing that may be excessive and/or inappropriate in context (e.g., laughing at a funeral while others are crying).
http://purl.obolibrary.org/obo/HP_0000751	Personality changes	http://purl.obolibrary.org/obo/HP_0031466	Impairment in personality functioning		An abnormal shift in patterns of thinking, acting, or feeling.
http://purl.obolibrary.org/obo/HP_0000752	Hyperactivity	http://purl.obolibrary.org/obo/HP_0000734	Disinhibition		Hyperactivity is a condition characterized by constant and unusually high levels of activity, even in situations where it is deemed inappropriate.
http://purl.obolibrary.org/obo/HP_0000756	Agoraphobia	http://purl.obolibrary.org/obo/HP_5200232	Phobia		A type of anxiety disorder characterized by the avoidance of public places, especially where crowds gather.
http://purl.obolibrary.org/obo/HP_0000757	Lack of insight	http://purl.obolibrary.org/obo/HP_5200401	Abnormal judgment		Lack of insight (Anosognosia) is a neurological condition in which an individual is unaware of his or her own neurological deficit or psychiatric condition. Anosognosia can be associated with mental illness, dementia, and structural brain lesions and can affect an individual's conscious awareness of deficits involving judgment, emotions, memory, executive function, language skills, and motor ability.
http://purl.obolibrary.org/obo/HP_0000758	Abnormal nonverbal communicative behavior	http://purl.obolibrary.org/obo/HP_0034434	Abnormal communication		Abnormalities in eye contact, communicative facial expressions, gesture use, or the use of others' bodies to communicate convey shared meanings within a culture that replace or supplement verbal communication.
http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology	http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology		A structural abnormality of the peripheral nervous system, which is composed of the nerves that lead to or branch off from the central nervous system. This includes the cranial nerves (olfactory and optic nerves are technically part of the central nervous system).
http://purl.obolibrary.org/obo/HP_0000762	Decreased nerve conduction velocity	http://purl.obolibrary.org/obo/HP_0040129	Abnormal nerve conduction velocity		A reduction in the speed at which electrical signals propagate along the axon of a neuron.
http://purl.obolibrary.org/obo/HP_0000763	Sensory neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		Peripheral neuropathy affecting the sensory nerves.
http://purl.obolibrary.org/obo/HP_0000764	Peripheral axonal degeneration	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Progressive deterioration of peripheral axons.
http://purl.obolibrary.org/obo/HP_0000765	Abnormal thorax morphology	http://purl.obolibrary.org/obo/HP_0009121	Abnormal axial skeleton morphology		Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs).
http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology	http://purl.obolibrary.org/obo/HP_0000765	Abnormal thorax morphology		An anomaly of the sternum, also known as the breastbone.
http://purl.obolibrary.org/obo/HP_0000767	Pectus excavatum	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		A defect of the chest wall characterized by a depression of the sternum, giving the chest ("pectus") a caved-in ("excavatum") appearance.
http://purl.obolibrary.org/obo/HP_0000769	Abnormality of the breast	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the breast.
http://purl.obolibrary.org/obo/HP_0000771	Gynecomastia	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		Abnormal development of large mammary glands in males resulting in breast enlargement.
http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		An anomaly of the rib.
http://purl.obolibrary.org/obo/HP_0000773	Short ribs	http://purl.obolibrary.org/obo/HP_0006712	Aplasia/Hypoplasia of the ribs		Reduced rib length.
http://purl.obolibrary.org/obo/HP_0000775	Abnormality of the diaphragm	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		Any abnormality of the diaphragm, the sheet of skeletal muscle that separates the thoracic cavity from the abdominal cavity.
http://purl.obolibrary.org/obo/HP_0000776	Congenital diaphragmatic hernia	http://purl.obolibrary.org/obo/HP_0100790	Hernia		The presence of a hernia of the diaphragm present at birth.
http://purl.obolibrary.org/obo/HP_0000778	Hypoplasia of the thymus	http://purl.obolibrary.org/obo/HP_0010515	Aplasia/Hypoplasia of the thymus		Underdevelopment of the thymus.
http://purl.obolibrary.org/obo/HP_0000782	Abnormal scapula morphology	http://purl.obolibrary.org/obo/HP_0000765	Abnormal thorax morphology		Any abnormality of the scapula, also known as the shoulder blade.
http://purl.obolibrary.org/obo/HP_0000787	Kidney stone	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Kidney stones (calculi) are mineral concretions in the renal calyces and pelvis that are found free or attached to the renal papillae.
http://purl.obolibrary.org/obo/HP_0000791	Uric acid nephrolithiasis	http://purl.obolibrary.org/obo/HP_0000787	Kidney stone		The presence of uric acid-containing calculi (stones) in the kidneys.
http://purl.obolibrary.org/obo/HP_0000793	Membranoproliferative glomerulonephritis	http://purl.obolibrary.org/obo/HP_0000099	Glomerulonephritis		A type of glomerulonephritis characterized by diffuse mesangial cell proliferation and the thickening of capillary walls due to subendothelial extension of the mesangium. The term membranoproliferative glomerulonephritis is often employed to denote a general pattern of glomerular injury seen in a variety of disease processes that share a common pathogenetic mechanism, rather than to describe a single disease entity
http://purl.obolibrary.org/obo/HP_0000794	IgA deposition in the glomerulus	http://purl.obolibrary.org/obo/HP_0030949	Glomerular deposits		The presence of immunoglobulin A deposits in the glomerulus.
http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra	http://purl.obolibrary.org/obo/HP_0010936	Abnormality of the lower urinary tract		An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body.
http://purl.obolibrary.org/obo/HP_0000796	Urethral obstruction	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		Obstruction of the flow of urine through the urethra.
http://purl.obolibrary.org/obo/HP_0000798	Oligozoospermia	http://purl.obolibrary.org/obo/HP_0008669	Abnormal spermatogenesis		Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen.
http://purl.obolibrary.org/obo/HP_0000799	Renal steatosis	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Abnormal fat accumulation in the kidneys.
http://purl.obolibrary.org/obo/HP_0000803	Renal cortical cysts	http://purl.obolibrary.org/obo/HP_0011035	Abnormal renal cortex morphology		Cysts of the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0000804	Xanthine nephrolithiasis	http://purl.obolibrary.org/obo/HP_0000787	Kidney stone		The presence of xanthine-containing calculi (stones) in the kidneys.
http://purl.obolibrary.org/obo/HP_0000805	Enuresis	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible.
http://purl.obolibrary.org/obo/HP_0000807	Glanular hypospadias	http://purl.obolibrary.org/obo/HP_0003244	Penile hypospadias		A type of hypospadias in which the urethral meatus is located at the head of the penis, but not all the way at the tip.
http://purl.obolibrary.org/obo/HP_0000808	Penoscrotal hypospadias	http://purl.obolibrary.org/obo/HP_0000047	Hypospadias		A severe form of hypospadias in which the urethral opening is located at the junction of the penis and scrotum.
http://purl.obolibrary.org/obo/HP_0000809	Urinary tract atresia	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the urinary system		Congenital absence of the normal opening of a structure of the urinary tract.
http://purl.obolibrary.org/obo/HP_0000811	Abnormal external genitalia morphology	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		A structural anomaly of the external genitalia.
http://purl.obolibrary.org/obo/HP_0000812	Abnormal internal genitalia	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		An anomaly of the adnexa, uterus, and vagina (in female) or seminal tract and prostate (in male).
http://purl.obolibrary.org/obo/HP_0000813	Bicornuate uterus	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		The presence of a bicornuate uterus.
http://purl.obolibrary.org/obo/HP_0000815	Hypergonadotropic hypogonadism	http://purl.obolibrary.org/obo/HP_0000135	Hypogonadism		Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay.
http://purl.obolibrary.org/obo/HP_0000816	Abnormality of Krebs cycle metabolism	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormality of the tricarboxylic acid cycle.
http://purl.obolibrary.org/obo/HP_0000817	Reduced eye contact	http://purl.obolibrary.org/obo/HP_0034435	Abnormal eye contact		A reduced frequency or duration of eye contact.
http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the endocrine system.
http://purl.obolibrary.org/obo/HP_0000820	Abnormality of the thyroid gland	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		An abnormality of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0000821	Hypothyroidism	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		Deficiency of thyroid hormone.
http://purl.obolibrary.org/obo/HP_0000822	Hypertension	http://purl.obolibrary.org/obo/HP_0032263	Increased blood pressure		The presence of chronic increased pressure in the systemic arterial system.
http://purl.obolibrary.org/obo/HP_0000823	Delayed puberty	http://purl.obolibrary.org/obo/HP_0001510	Growth delay		Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.
http://purl.obolibrary.org/obo/HP_0000824	Decreased response to growth hormone stimulation test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests.
http://purl.obolibrary.org/obo/HP_0000825	Hyperinsulinemic hypoglycemia	http://purl.obolibrary.org/obo/HP_0000842	Hyperinsulinemia		An increased concentration of insulin combined with a decreased concentration of glucose in the blood.
http://purl.obolibrary.org/obo/HP_0000826	Precocious puberty	http://purl.obolibrary.org/obo/HP_0100000	Early onset of sexual maturation		The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys.
http://purl.obolibrary.org/obo/HP_0000828	Abnormality of the parathyroid gland	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		An abnormality of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0000829	Hypoparathyroidism	http://purl.obolibrary.org/obo/HP_0011767	Abnormality of the parathyroid physiology		A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia.
http://purl.obolibrary.org/obo/HP_0000830	Anterior hypopituitarism	http://purl.obolibrary.org/obo/HP_0040075	Hypopituitarism		A condition of reduced function of the anterior pituitary gland characterized by decreased secretion of one or more of the pituitary hormones growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, and follicle-stimulating hormone.
http://purl.obolibrary.org/obo/HP_0000831	Insulin-resistant diabetes mellitus	http://purl.obolibrary.org/obo/HP_0000819	Diabetes mellitus		A type of diabetes mellitus related not to lack of insulin but rather to lack of response to insulin on the part of the target tissues of insulin such as muscle, fat, and liver cells. This type of diabetes is typically associated with increases both in blood glucose concentrations as well as in fasting and postprandial serum insulin levels.
http://purl.obolibrary.org/obo/HP_0000832	Primary hypothyroidism	http://purl.obolibrary.org/obo/HP_0000821	Hypothyroidism		A type of hypothyroidism that results from a defect in the thyroid gland.
http://purl.obolibrary.org/obo/HP_0000834	Abnormality of the adrenal glands	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kindneys.
http://purl.obolibrary.org/obo/HP_0000835	Adrenal hypoplasia	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Developmental hypoplasia of the adrenal glands.
http://purl.obolibrary.org/obo/HP_0000836	Hyperthyroidism	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3).
http://purl.obolibrary.org/obo/HP_0000837	Increased circulating gonadotropin level	http://purl.obolibrary.org/obo/HP_0030338	Abnormal circulating gonadotropin concentration		Overproduction of gonadotropins (FSH, LH) by the anterior pituitary gland.
http://purl.obolibrary.org/obo/HP_0000839	Pituitary dwarfism	http://purl.obolibrary.org/obo/HP_0004322	Short stature		A type of reduced stature with normal proportions related to dysfunction of the pituitary gland related to either an isolated defect in the secretion of growth hormone or to panhypopituitarism, i.e., a deficit of all the anterior pituitary hormones.
http://purl.obolibrary.org/obo/HP_0000840	Adrenogenital syndrome	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects.
http://purl.obolibrary.org/obo/HP_0000841	Hyperactive renin-angiotensin system	http://purl.obolibrary.org/obo/HP_0000847	Abnormality of renin-angiotensin system		An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms.
http://purl.obolibrary.org/obo/HP_0000842	Hyperinsulinemia	http://purl.obolibrary.org/obo/HP_0040214	Abnormal circulating insulin concentration		An increased concentration of insulin in the blood.
http://purl.obolibrary.org/obo/HP_0000843	Hyperparathyroidism	http://purl.obolibrary.org/obo/HP_0011767	Abnormality of the parathyroid physiology		Excessive production of parathyroid hormone (PTH) by the parathyroid glands.
http://purl.obolibrary.org/obo/HP_0000845	Elevated circulating growth hormone concentration	http://purl.obolibrary.org/obo/HP_0032367	Abnormal circulating growth hormone concentration		Acromegaly is a condition resulting from overproduction of growth hormone by the pituitary gland in persons with closed epiphyses, and consists chiefly in the enlargement of the distal parts of the body. The circumference of the skull increases, the nose becomes broad, the tongue becomes enlarged, the facial features become coarsened, the mandible grows excessively, and the teeth become separated. The fingers and toes grow chiefly in thickness.
http://purl.obolibrary.org/obo/HP_0000846	Adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0011733	Abnormality of adrenal physiology		Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.
http://purl.obolibrary.org/obo/HP_0000847	Abnormality of renin-angiotensin system	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		An abnormality of the renin-angiotensin system.
http://purl.obolibrary.org/obo/HP_0000848	Increased circulating renin concentration	http://purl.obolibrary.org/obo/HP_0040084	Abnormal circulating renin concentration		An increased level of renin in the blood.
http://purl.obolibrary.org/obo/HP_0000851	Congenital hypothyroidism	http://purl.obolibrary.org/obo/HP_0000821	Hypothyroidism		A type of hypothyroidism with congenital onset.
http://purl.obolibrary.org/obo/HP_0000852	Pseudohypoparathyroidism	http://purl.obolibrary.org/obo/HP_0011767	Abnormality of the parathyroid physiology		A condition characterized by resistance to the action of parathyroid hormone, in which there is hypocalcemia, hyperphosphatemia, and (appropriately) high levels of parathyroid hormone.
http://purl.obolibrary.org/obo/HP_0000853	Goiter	http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology		An enlargement of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0000854	Thyroid adenoma	http://purl.obolibrary.org/obo/HP_0100031	Neoplasm of the thyroid gland		The presence of a adenoma of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0000855	Insulin resistance	http://purl.obolibrary.org/obo/HP_0011014	Abnormal glucose homeostasis		Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels.
http://purl.obolibrary.org/obo/HP_0000858	Irregular menstruation	http://purl.obolibrary.org/obo/HP_0000140	Abnormality of the menstrual cycle		Abnormally high variation in the amount of time between periods.
http://purl.obolibrary.org/obo/HP_0000859	Increased circulating aldosterone concentration	http://purl.obolibrary.org/obo/HP_0040085	Abnormal circulating aldosterone concentration		Overproduction of the mineralocorticoid aldosterone by the adrenal cortex.
http://purl.obolibrary.org/obo/HP_0000860	Parathyroid hypoplasia	http://purl.obolibrary.org/obo/HP_0011768	Parathyroid dysgenesis		Developmental hypoplasia of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0000863	Central diabetes insipidus	http://purl.obolibrary.org/obo/HP_0000873	Diabetes insipidus		A form of diabetes insipidus related to a failure of vasopressin (AVP) release from the hypothalamus.
http://purl.obolibrary.org/obo/HP_0000864	Abnormality of the hypothalamus-pituitary axis	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit.
http://purl.obolibrary.org/obo/HP_0000867	Secondary hyperparathyroidism	http://purl.obolibrary.org/obo/HP_0000843	Hyperparathyroidism		Secondary hyperparathyroidism refers to the production of higher than normal levels of parathyroid hormone in the presence of hypocalcemia.
http://purl.obolibrary.org/obo/HP_0000870	Increased circulating prolactin concentration	http://purl.obolibrary.org/obo/HP_0010514	Hyperpituitarism		The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy.
http://purl.obolibrary.org/obo/HP_0000871	Panhypopituitarism	http://purl.obolibrary.org/obo/HP_0000830	Anterior hypopituitarism		A pituitary functional deficit affecting all the anterior pituitary hormones (growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, and prolactin).
http://purl.obolibrary.org/obo/HP_0000872	Hashimoto thyroiditis	http://purl.obolibrary.org/obo/HP_0002960	Autoimmunity		A chronic, autoimmune type of thyroiditis associated with hypothyroidism.
http://purl.obolibrary.org/obo/HP_0000873	Diabetes insipidus	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		A state of excessive water intake and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus).
http://purl.obolibrary.org/obo/HP_0000876	Oligomenorrhea	http://purl.obolibrary.org/obo/HP_0000140	Abnormality of the menstrual cycle		Infrequent menses (less than 6 per year or more than 35 days between cycles).
http://purl.obolibrary.org/obo/HP_0000878	11 pairs of ribs	http://purl.obolibrary.org/obo/HP_0000921	Missing ribs		Presence of only 11 pairs of ribs.
http://purl.obolibrary.org/obo/HP_0000879	Short sternum	http://purl.obolibrary.org/obo/HP_0006714	Aplasia/Hypoplasia of the sternum		Decreased inferosuperior length of the sternum.
http://purl.obolibrary.org/obo/HP_0000882	Hypoplastic scapulae	http://purl.obolibrary.org/obo/HP_0006713	Aplasia/Hypoplasia of the scapulae		Underdeveloped scapula.
http://purl.obolibrary.org/obo/HP_0000883	Thin ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		Ribs with a reduced diameter.
http://purl.obolibrary.org/obo/HP_0000885	Broad ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		Increased width of ribs
http://purl.obolibrary.org/obo/HP_0000886	Deformed rib cage	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		Malformation of the rib cage.
http://purl.obolibrary.org/obo/HP_0000887	Cupped ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		Wide, concave rib end.
http://purl.obolibrary.org/obo/HP_0000888	Horizontal ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		A horizontal (flat) conformation of the ribs, the long curved bones that form the rib cage and normally progressively oblique (slanted) from ribs 1 through 9, then less slanted through rib 12.
http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology	http://purl.obolibrary.org/obo/HP_0000765	Abnormal thorax morphology		Any abnormality of the clavicles (collar bones).
http://purl.obolibrary.org/obo/HP_0000890	Long clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		Increased length of the clavicles.
http://purl.obolibrary.org/obo/HP_0000892	Bifid ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		A bifid rib refers to cleavage of the sternal end of a rib, usually unilateral. Bifid ribs are usually asymptomatic, and are often discovered incidentally by chest x-ray.
http://purl.obolibrary.org/obo/HP_0000893	Bulging of the costochondral junction	http://purl.obolibrary.org/obo/HP_0000919	Abnormality of the costochondral junction		Abnormal outward curving (protuberance) of the junction of ribs and costal cartilage.
http://purl.obolibrary.org/obo/HP_0000894	Short clavicles	http://purl.obolibrary.org/obo/HP_0006710	Aplasia/Hypoplasia of the clavicles		Reduced length of the clavicles.
http://purl.obolibrary.org/obo/HP_0000895	Lateral clavicle hook	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		An excessive upward convexity of the lateral clavicle.
http://purl.obolibrary.org/obo/HP_0000896	Rib exostoses	http://purl.obolibrary.org/obo/HP_0100777	Exostoses		Multiple circumscribed bony excrescences located in the ribs.
http://purl.obolibrary.org/obo/HP_0000897	Rachitic rosary	http://purl.obolibrary.org/obo/HP_0000919	Abnormality of the costochondral junction		A row of beadlike prominences at the junction of a rib and its cartilage (i.e., enlarged costochondral joints), resembling a rosary. Note that rachitic rosary would have one bead per rib (a swelling at the costochondral junction), while beaded ribs in the context of multiple rib fractures have multiple beads (fractures) along the same rib.
http://purl.obolibrary.org/obo/HP_0000900	Thickened ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		Increased thickness (diameter) of ribs.
http://purl.obolibrary.org/obo/HP_0000902	Rib fusion	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		Complete or partial merging of adjacent ribs.
http://purl.obolibrary.org/obo/HP_0000904	Flaring of rib cage	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		The presence of wide, concave anterior rib ends.
http://purl.obolibrary.org/obo/HP_0000905	Progressive clavicular acroosteolysis	http://purl.obolibrary.org/obo/HP_0002797	Osteolysis		Progressive bone resorption in the distal part of the clavicle.
http://purl.obolibrary.org/obo/HP_0000907	Anterior rib cupping	http://purl.obolibrary.org/obo/HP_0000887	Cupped ribs		Wide, concave anterior rib end.
http://purl.obolibrary.org/obo/HP_0000911	Flat glenoid fossa	http://purl.obolibrary.org/obo/HP_0011912	Abnormality of the glenoid fossa		Abnormally flat configuration of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus.
http://purl.obolibrary.org/obo/HP_0000912	Sprengel anomaly	http://purl.obolibrary.org/obo/HP_0000782	Abnormal scapula morphology		A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other).
http://purl.obolibrary.org/obo/HP_0000913	Posterior rib fusion	http://purl.obolibrary.org/obo/HP_0000902	Rib fusion		Complete or partial merging of the posterior part of adjacent ribs.
http://purl.obolibrary.org/obo/HP_0000914	Shield chest	http://purl.obolibrary.org/obo/HP_0100625	Enlarged thorax		A broad chest.
http://purl.obolibrary.org/obo/HP_0000915	Pectus excavatum of inferior sternum	http://purl.obolibrary.org/obo/HP_0000767	Pectus excavatum		Pectus excavatum (defect of the chest wall characterized by depression of the sternum) affecting primarily the inferior region of the sternum.
http://purl.obolibrary.org/obo/HP_0000916	Broad clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		Increased width (cross-sectional diameter) of the clavicles.
http://purl.obolibrary.org/obo/HP_0000917	Superior pectus carinatum	http://purl.obolibrary.org/obo/HP_0000768	Pectus carinatum		Pectus carinatum affecting primarily the superior part of the sternum.
http://purl.obolibrary.org/obo/HP_0000918	Scapular exostoses	http://purl.obolibrary.org/obo/HP_0100777	Exostoses		The presence of multiple exostoses on the scapula. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage.
http://purl.obolibrary.org/obo/HP_0000919	Abnormality of the costochondral junction	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		Any anomaly of the costochondral junction. The costochondral junctions are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum.
http://purl.obolibrary.org/obo/HP_0000920	Enlargement of the costochondral junction	http://purl.obolibrary.org/obo/HP_0000919	Abnormality of the costochondral junction		Abnormally increased size of the costochondral junctions, which are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum.
http://purl.obolibrary.org/obo/HP_0000921	Missing ribs	http://purl.obolibrary.org/obo/HP_0006712	Aplasia/Hypoplasia of the ribs		A developmental anomaly with absence of one or more ribs.
http://purl.obolibrary.org/obo/HP_0000922	Posterior rib cupping	http://purl.obolibrary.org/obo/HP_0000887	Cupped ribs		Wide, concave posterior rib end.
http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column	http://purl.obolibrary.org/obo/HP_0009121	Abnormal axial skeleton morphology		Any abnormality of the vertebral column.
http://purl.obolibrary.org/obo/HP_0000927	Abnormality of skeletal maturation	http://purl.obolibrary.org/obo/HP_0011843	Abnormal musculoskeletal physiology		The bones of the skeleton undergo a series of characteristic changes in size, shape, and calcification from fetal life until puberty. An abnormality of this process can include delayed or accelerated skeletal maturation, or deviation of some, but not all bones from the expected patterns of maturation.
http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology	http://purl.obolibrary.org/obo/HP_0009121	Abnormal axial skeleton morphology		An abnormality of the skull, the bony framework of the head which is comprised of the neurocranium (with eight cranial bones) and the viscerocranium (facial skeleton) that comprises fourteen facial bones with the mandible as its largest bone.
http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology	http://purl.obolibrary.org/obo/HP_0002693	Abnormal skull base morphology		An abnormality of the fossa cranii posterior (the posterior fossa), which is made up primarily of the occipital bone and which surrounds to the foramen magnum.
http://purl.obolibrary.org/obo/HP_0000934	Chondrocalcinosis	http://purl.obolibrary.org/obo/HP_0100685	Abnormal Sharpey fiber morphology		Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) .
http://purl.obolibrary.org/obo/HP_0000935	Thickened cortex of long bones	http://purl.obolibrary.org/obo/HP_0100039	Thickened cortex of bones		Abnormal thickening of the cortex of long bones.
http://purl.obolibrary.org/obo/HP_0000938	Osteopenia	http://purl.obolibrary.org/obo/HP_0004349	Reduced bone mineral density		Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5.
http://purl.obolibrary.org/obo/HP_0000939	Osteoporosis	http://purl.obolibrary.org/obo/HP_0004349	Reduced bone mineral density		Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).
http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		An abnormality of the structure or form of the diaphysis, i.e., of the main or mid-section (shaft) of a long bone.
http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		An abnormality of one or more metaphysis, i.e., of the somewhat wider portion of a long bone that is adjacent to the epiphyseal growth plate and grows during childhood.
http://purl.obolibrary.org/obo/HP_0000946	Hypoplastic ilia	http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology		Underdevelopment of the ilium.
http://purl.obolibrary.org/obo/HP_0000947	Dumbbell-shaped long bone	http://purl.obolibrary.org/obo/HP_0003016	Metaphyseal widening		An abnormal appearance of the long bones with resemblance to a dumbbell, a short bar with a weight at each end. That is, the long bone is shortened and displays flaring (widening) of the metaphyses.
http://purl.obolibrary.org/obo/HP_0000951	Abnormality of the skin	http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the integument		An abnormality of the skin.
http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		A darkening of the skin related to an increase in melanin production and deposition.
http://purl.obolibrary.org/obo/HP_0000954	Single transverse palmar crease	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		The distal and proximal transverse palmar creases are merged into a single transverse palmar crease.
http://purl.obolibrary.org/obo/HP_0000956	Acanthosis nigricans	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		A dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck.
http://purl.obolibrary.org/obo/HP_0000957	Cafe-au-lait spot	http://purl.obolibrary.org/obo/HP_0001034	Hypermelanotic macule		Cafe-au-lait spots are hyperpigmented lesions that can vary in color from light brown to dark brown with smooth borders and having a size of 1.5 cm or more in adults and 0.5 cm or more in children.
http://purl.obolibrary.org/obo/HP_0000958	Dry skin	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Skin characterized by the lack of natural or normal moisture.
http://purl.obolibrary.org/obo/HP_0000960	Sacral dimple	http://purl.obolibrary.org/obo/HP_0010781	Skin dimple		A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the intergluteal cleft.
http://purl.obolibrary.org/obo/HP_0000961	Cyanosis	http://purl.obolibrary.org/obo/HP_0001005	Dermatological manifestations of systemic disorders		Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood.
http://purl.obolibrary.org/obo/HP_0000963	Thin skin	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.
http://purl.obolibrary.org/obo/HP_0000965	Cutis marmorata	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		A reticular discoloration of the skin with cyanotic (reddish-blue appearing) areas surrounding pale central areas due to dilation of capillary blood vessels and stagnation of blood within the vessels. Cutis marmorata generally occurs on the legs, arms and trunk and is often more severe in cold weather.
http://purl.obolibrary.org/obo/HP_0000966	Hypohidrosis	http://purl.obolibrary.org/obo/HP_0007550	Hypohidrosis or hyperhidrosis		Abnormally diminished capacity to sweat.
http://purl.obolibrary.org/obo/HP_0000968	Ectodermal dysplasia	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		Ectodermal dysplasia is a group of conditions in which there is abnormal development of the skin, hair, nails, teeth, or sweat glands.
http://purl.obolibrary.org/obo/HP_0000970	Anhidrosis	http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology		Inability to sweat.
http://purl.obolibrary.org/obo/HP_0000971	Abnormal sweat gland morphology	http://purl.obolibrary.org/obo/HP_0011138	Abnormal skin adnexa morphology		Any structural abnormality of the sweat gland.
http://purl.obolibrary.org/obo/HP_0000973	Cutis laxa	http://purl.obolibrary.org/obo/HP_0008067	Abnormally lax or hyperextensible skin		Wrinkled, redundant, inelastic and sagging skin.
http://purl.obolibrary.org/obo/HP_0000974	Hyperextensible skin	http://purl.obolibrary.org/obo/HP_0008067	Abnormally lax or hyperextensible skin		A condition in which the skin can be stretched beyond normal, and then returns to its initial position.
http://purl.obolibrary.org/obo/HP_0000977	Soft skin	http://purl.obolibrary.org/obo/HP_0010647	Abnormal elasticity of skin		Subjective impression of increased softness upon palpation of the skin.
http://purl.obolibrary.org/obo/HP_0000979	Purpura	http://purl.obolibrary.org/obo/HP_0001933	Subcutaneous hemorrhage		Purpura (from Latin: purpura, meaning purple) is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This term refers to an abnormally increased susceptibility to developing purpura. Purpura are larger than petechiae.
http://purl.obolibrary.org/obo/HP_0000980	Pallor	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Abnormally pale skin.
http://purl.obolibrary.org/obo/HP_0000982	Palmoplantar keratoderma	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		Abnormal thickening of the skin of the palms of the hands and the soles of the feet.
http://purl.obolibrary.org/obo/HP_0000987	Atypical scarring of skin	http://purl.obolibrary.org/obo/HP_0100699	Scarring		Atypically scarred skin .
http://purl.obolibrary.org/obo/HP_0000991	Xanthomatosis	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		The presence of multiple xanthomas (xanthomata) in the skin. Xanthomas are yellowish, firm, lipid-laden nodules in the skin.
http://purl.obolibrary.org/obo/HP_0000992	Cutaneous photosensitivity	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		An increased sensitivity of the skin to light. Photosensitivity may result in a rash upon exposure to the sun (which is known as photodermatosis). Photosensitivity can be diagnosed by phototests in which light is shone on small areas of skin.
http://purl.obolibrary.org/obo/HP_0000993	Molluscoid pseudotumors	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Bluish-grey, spongy nodules associated with scars over pressure points and easily traumatized areas like the elbows and knees.
http://purl.obolibrary.org/obo/HP_0000995	Melanocytic nevus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger.
http://purl.obolibrary.org/obo/HP_0000996	Facial capillary hemangioma	http://purl.obolibrary.org/obo/HP_0005306	Capillary hemangioma		Hemangioma, a benign tumor of the vascular endothelial cells with small endothelial spaces, occurring in the face.
http://purl.obolibrary.org/obo/HP_0000997	Axillary freckling	http://purl.obolibrary.org/obo/HP_0001480	Freckling		The presence in the axillary region (armpit) of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin.
http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		Hypertrichosis is increased hair growth that is abnormal in quantity or location.
http://purl.obolibrary.org/obo/HP_0001003	Multiple lentigines	http://purl.obolibrary.org/obo/HP_0001034	Hypermelanotic macule		Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots.
http://purl.obolibrary.org/obo/HP_0001007	Hirsutism	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		Abnormally increased hair growth referring to a male pattern of body hair (androgenic hair).
http://purl.obolibrary.org/obo/HP_0001009	Telangiectasia	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		Telangiectasias refer to small dilated blood vessels located near the surface of the skin or mucous membranes, measuring between 0.5 and 1 millimeter in diameter. Telangiectasia are located especially on the tongue, lips, palate, fingers, face, conjunctiva, trunk, nail beds, and fingertips.
http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		A reduction of skin color related to a decrease in melanin production and deposition.
http://purl.obolibrary.org/obo/HP_0001012	Multiple lipomas	http://purl.obolibrary.org/obo/HP_0012031	Lipomatous tumor		The presence of multiple lipomas (a type of benign tissue made of fatty tissue).
http://purl.obolibrary.org/obo/HP_0001013	Eruptive xanthomas	http://purl.obolibrary.org/obo/HP_0000991	Xanthomatosis		Eruptive xanthomas are yellow-orange-to-red-brown papules that are often surrounded by an erythematous halo. They appear in crops on the buttocks, extensor surfaces of the extremities, and flexural creases. Acutely, variable amounts of pruritus and pain occur.
http://purl.obolibrary.org/obo/HP_0001014	Angiokeratoma	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		Angiokeratomas are hyperkeratotic papules that are characterized histologically by superficial ectatic (i.e., dilated) blood vessels with epidermal proliferation. Clinically, angiokeratoma presents as a small, raised, dark-red spot.
http://purl.obolibrary.org/obo/HP_0001015	Prominent superficial veins	http://purl.obolibrary.org/obo/HP_0007394	Prominent superficial blood vessels		A condition in which superficial veins (i.e., veins just under the skin) are more conspicuous or noticeable than normal.
http://purl.obolibrary.org/obo/HP_0001017	Anemic pallor	http://purl.obolibrary.org/obo/HP_0000980	Pallor		A type of pallor that is secondary to the presence of anemia.
http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		An abnormality of the dermatoglyphs, i.e., an abnormality of the patterns of ridges of the skin of palm of hand.
http://purl.obolibrary.org/obo/HP_0001019	Erythroderma	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever.
http://purl.obolibrary.org/obo/HP_0001027	Soft, doughy skin	http://purl.obolibrary.org/obo/HP_0000977	Soft skin		A skin texture that is unusually soft (and may feel silky), and has a malleable consistency resembling that of dough.
http://purl.obolibrary.org/obo/HP_0001028	Hemangioma	http://purl.obolibrary.org/obo/HP_0100742	Vascular neoplasm		A hemangioma is a benign tumor characterized by blood-filled spaces lined by benign endothelial cells. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma (in contrast to a hemangioma with small endothelial spaces, which is called capillary hemangioma).
http://purl.obolibrary.org/obo/HP_0001029	Poikiloderma	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Poikiloderma refers to a patch of skin with (1) reticulated hypopigmentation and hyperpigmentation, (2) wrinkling secondary to epidermal atrophy, and (3) telangiectasias.
http://purl.obolibrary.org/obo/HP_0001030	Fragile skin	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		Skin that splits easily with minimal injury.
http://purl.obolibrary.org/obo/HP_0001031	Subcutaneous lipoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		The presence of subcutaneous lipoma.
http://purl.obolibrary.org/obo/HP_0001032	Absent distal interphalangeal creases	http://purl.obolibrary.org/obo/HP_0006109	Absent phalangeal crease		Absence of the distal interphalangeal flexion creases of the fingers.
http://purl.obolibrary.org/obo/HP_0001034	Hypermelanotic macule	http://purl.obolibrary.org/obo/HP_0012733	Macule		A hyperpigmented circumscribed area of change in normal skin color without elevation or depression of any size.
http://purl.obolibrary.org/obo/HP_0001036	Parakeratosis	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		Abnormal formation of the keratinocytes of the epidermis characterized by persistence of nuclei, incomplete formation of keratin, and moistness and swelling of the keratinocytes.
http://purl.obolibrary.org/obo/HP_0001041	Facial erythema	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin.
http://purl.obolibrary.org/obo/HP_0001046	Intermittent jaundice	http://purl.obolibrary.org/obo/HP_0000952	Jaundice		Jaundice that is sometimes present, sometimes not.
http://purl.obolibrary.org/obo/HP_0001047	Atopic dermatitis	http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis		Atopic dermatitis (AD) or atopic eczema is an itchy, inflammatory skin condition with a predilection for the skin flexures. It is characterized by poorly defined erythema with edema, vesicles, and weeping in the acute stage and skin thickening (lichenification) in the chronic stage.
http://purl.obolibrary.org/obo/HP_0001048	Cavernous hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		The presence of a cavernous hemangioma. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma.
http://purl.obolibrary.org/obo/HP_0001051	Seborrheic dermatitis	http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis		Seborrheic dermatitis is a form of eczema which is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk.
http://purl.obolibrary.org/obo/HP_0001052	Nevus flammeus	http://purl.obolibrary.org/obo/HP_0025104	Capillary malformation		A congenital vascular malformation consisting of superficial and deep dilated capillaries in the skin which produce a reddish to purplish discolouration of the skin.
http://purl.obolibrary.org/obo/HP_0001055	Erysipelas	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Increased susceptibility to erysipelas, as manifested by a medical history of repeated episodes of erysipelas, which is a superficial infection of the skin, typically involving the lymphatic system.
http://purl.obolibrary.org/obo/HP_0001056	Milia	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Presence of multiple small cysts containing keratin (skin protein) and presenting as tiny pearly-white bumps just under the surface of the skin.
http://purl.obolibrary.org/obo/HP_0001057	Aplasia cutis congenita	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		A developmental defect resulting in the congenital absence of skin in multiple or solitary non-inflammatory, well-demarcated, oval or circular ulcers with a diameter of about 1 to 2 cm. Aplasia cutis congenita most commonly occurs on the scalp, but may present in the face, trunk, or limbs.
http://purl.obolibrary.org/obo/HP_0001058	Poor wound healing	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		A reduced ability to heal cutaneous wounds.
http://purl.obolibrary.org/obo/HP_0001059	Pterygium	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		Pterygia are 'winglike' triangular membranes occurring in the neck, eyes, knees, elbows, ankles or digits.
http://purl.obolibrary.org/obo/HP_0001060	Axillary pterygium	http://purl.obolibrary.org/obo/HP_0001059	Pterygium		Presence of a cutaneous membrane (flap) in the armpit.
http://purl.obolibrary.org/obo/HP_0001061	Acne	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts).
http://purl.obolibrary.org/obo/HP_0001062	Atypical nevus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		A large pigmented lesion measuring 5-15 mm in diameter with irregular, notched, and ill defined border and with color that may range from tan to dark brown to pink.
http://purl.obolibrary.org/obo/HP_0001063	Acrocyanosis	http://purl.obolibrary.org/obo/HP_0034033	Peripheral cyanosis		Bluish discoloration of the skin of the hands or feet.
http://purl.obolibrary.org/obo/HP_0001065	Striae distensae	http://purl.obolibrary.org/obo/HP_0100679	Lack of skin elasticity		Thinned, erythematous, depressed bands of atrophic skin. Initially, striae appear as flattened and thinned, pinkish linear regions of the skin. Striae tend to enlarge in length and become reddish or purplish. Later, striae tend to appear as white, depressed bands that are parallel to the lines of skin tension. Striae distensae occur most often in areas that have been subject to distension such as the lower back, buttocks, thighs, breast, abdomen, and shoulders.
http://purl.obolibrary.org/obo/HP_0001067	Neurofibroma	http://purl.obolibrary.org/obo/HP_0100007	Neoplasm of the peripheral nervous system		A benign peripheral nerve sheath tumor that generally appears as a soft, skin-colored papule or small subcutaneous nodule. Individuals with neurofibromatosis can have numerous neurofibromas.
http://purl.obolibrary.org/obo/HP_0001069	Episodic hyperhidrosis	http://purl.obolibrary.org/obo/HP_0000975	Hyperhidrosis		Intermittent episodes of abnormally increased perspiration.
http://purl.obolibrary.org/obo/HP_0001070	Mottled pigmentation	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		Patchy and irregular skin pigmentation.
http://purl.obolibrary.org/obo/HP_0001071	Angiokeratoma corporis diffusum	http://purl.obolibrary.org/obo/HP_0001014	Angiokeratoma		Angiokeratoma corporis diffusum (ACD) is typically characterized by innumerable small red to black papules which occur in clusters and are situated symmetrically in the bathing trunks area. The number of lesions and the extension of the body increase steadily with time so that generalization and mucosal involvement are common. The single lesion begins with a minute reddish papule which enlarges to up to 10 mm in diameter, becomes dark red to black with a discrete keratotic overgrowth. Histologically, the papules are characterized by superficial dilated capillaries in papillary dermis with epidermal proliferation.
http://purl.obolibrary.org/obo/HP_0001072	Thickened skin	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Laminar thickening of skin.
http://purl.obolibrary.org/obo/HP_0001073	Cigarette-paper scars	http://purl.obolibrary.org/obo/HP_0001075	Atrophic scars		Thin (atrophic) and wide scars.
http://purl.obolibrary.org/obo/HP_0001075	Atrophic scars	http://purl.obolibrary.org/obo/HP_0004334	Dermal atrophy		Scars that form a depression compared to the level of the surrounding skin because of damage to the collagen, fat or other tissues below the skin.
http://purl.obolibrary.org/obo/HP_0001080	Biliary tract abnormality	http://purl.obolibrary.org/obo/HP_0004297	Abnormality of the biliary system		An abnormality of the biliary tree.
http://purl.obolibrary.org/obo/HP_0001081	Cholelithiasis	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Hard, pebble-like deposits that form within the gallbladder.
http://purl.obolibrary.org/obo/HP_0001082	Cholecystitis	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		The presence of inflammatory changes in the gallbladder.
http://purl.obolibrary.org/obo/HP_0001083	Ectopia lentis	http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology		Dislocation or malposition of the crystalline lens of the eye. A partial displacement (or dislocation) of the lens is described as a subluxation of the lens, while a complete displacement is termed luxation of the lens. A complete displacement occurs if the lens is completely outside the patellar fossa of the lens, either in the anterior chamber, in the vitreous, or directly on the retina. If the lens is partially displaced but still contained within the lens space, then it is termed subluxation.
http://purl.obolibrary.org/obo/HP_0001084	Corneal arcus	http://purl.obolibrary.org/obo/HP_0008011	Peripheral opacification of the cornea		A hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years.
http://purl.obolibrary.org/obo/HP_0001085	Papilledema	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		Papilledema refers to edema (swelling) of the optic disc secondary to any factor which increases cerebral spinal fluid pressure.
http://purl.obolibrary.org/obo/HP_0001087	Developmental glaucoma	http://purl.obolibrary.org/obo/HP_0007700	Ocular anterior segment dysgenesis		Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma.
http://purl.obolibrary.org/obo/HP_0001088	Brushfield spots	http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation		The presence of whitish spots in a ring-like arrangement at the periphery of the iris.
http://purl.obolibrary.org/obo/HP_0001089	Iris atrophy	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		Loss of iris tissue (atrophy)
http://purl.obolibrary.org/obo/HP_0001090	Abnormally large globe	http://purl.obolibrary.org/obo/HP_0100887	Abnormality of globe size		Diffusely large eye (with megalocornea) without glaucoma.
http://purl.obolibrary.org/obo/HP_0001092	Absent lacrimal punctum	http://purl.obolibrary.org/obo/HP_0011479	Abnormal lacrimal punctum morphology		No identifiable superior and/or inferior lacrimal punctum.
http://purl.obolibrary.org/obo/HP_0001093	Optic nerve dysplasia	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		The presence of developmental dysplasia of the optic nerve.
http://purl.obolibrary.org/obo/HP_0001094	Iridocyclitis	http://purl.obolibrary.org/obo/HP_0012122	Anterior uveitis		A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body.
http://purl.obolibrary.org/obo/HP_0001095	Hypertensive retinopathy	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		Condition of the retina, secondary to severe systemic arterial hypertension which can be acute or longstanding. Features include one or several of the following: retinal vascular tortuosity, arteriovenous crossing signs, retinal cotton wool spot and intraretinal hemorrhages. It can be associated with optic disc swelling.
http://purl.obolibrary.org/obo/HP_0001096	Keratoconjunctivitis	http://purl.obolibrary.org/obo/HP_0000509	Conjunctivitis		Inflammation of the cornea and conjunctiva.
http://purl.obolibrary.org/obo/HP_0001097	Keratoconjunctivitis sicca	http://purl.obolibrary.org/obo/HP_0001096	Keratoconjunctivitis		Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids.
http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology	http://purl.obolibrary.org/obo/HP_0004329	Abnormal posterior eye segment morphology		Any structural abnormality of the fundus of the eye.
http://purl.obolibrary.org/obo/HP_0001099	Atrophic fundus lesion	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Well-defined or diffused area or lesion of loss of normal retinal tissue; this is often illustrated by greyish discoloration of fundus and/or better visible choroidal vasculature on funduscopy.
http://purl.obolibrary.org/obo/HP_0001100	Heterochromia iridis	http://purl.obolibrary.org/obo/HP_0200064	Asymmetry of iris pigmentation		Heterochromia iridis is a difference in the color of the iris in the two eyes.
http://purl.obolibrary.org/obo/HP_0001101	Iritis	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		Inflammation of the iris.
http://purl.obolibrary.org/obo/HP_0001102	Angioid streaks	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Irregular lines in the outer retina and Bruch membrane that are typically configured in a radiating fashion and emanate from the optic disc. Angioid streaks are crack-like dehiscences in abnormally thickened and calcified Bruch membrane, resulting in atrophy of the overlying retinal pigment epithelium. They may be associated with a number of endocrine, metabolic, and connective tissue abnormalities but can be idiopathic. They can be associated with neovascular complexes (choroid).
http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		A structural abnormality of the macula, a region that, in a clinical context, is typically used to describe the central part of the retina within the vascular arcades.
http://purl.obolibrary.org/obo/HP_0001104	Macular hypoplasia	http://purl.obolibrary.org/obo/HP_0008059	Aplasia/Hypoplasia of the macula		Underdevelopment of the macula lutea.
http://purl.obolibrary.org/obo/HP_0001105	Retinal atrophy	http://purl.obolibrary.org/obo/HP_0000546	Retinal degeneration		A nonspecific term denoting wasting, especially as a result of degeneration, of the retinal pigment epithelium (RPE) and neurosensory retinal cells.
http://purl.obolibrary.org/obo/HP_0001106	Periorbital hyperpigmentation	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		Increased pigmentation of the skin in the region surrounding the orbit of the eye.
http://purl.obolibrary.org/obo/HP_0001107	Ocular albinism	http://purl.obolibrary.org/obo/HP_0007730	Iris hypopigmentation		An abnormal reduction in the amount of pigmentation (reduced or absent) of the iris and retina.
http://purl.obolibrary.org/obo/HP_0001112	Leber optic atrophy	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		Degeneration of retinal ganglion cells and their axons.
http://purl.obolibrary.org/obo/HP_0001114	Xanthelasma	http://purl.obolibrary.org/obo/HP_0010732	Nodular changes affecting the eyelids		The presence of xanthomata in the skin of the eyelid.
http://purl.obolibrary.org/obo/HP_0001115	Posterior polar cataract	http://purl.obolibrary.org/obo/HP_0010696	Polar cataract		A polar cataract that affects the posterior pole of the lens.
http://purl.obolibrary.org/obo/HP_0001116	Macular pseudocoloboma	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		A so-called macular coloboma is characterized by a sharply defined, usually excavated, area without neuroretina and RPE tissues in the central area of the fundus. This lesion is not related to classical colobomas associated with optic fissure closure defects.
http://purl.obolibrary.org/obo/HP_0001117	Sudden loss of visual acuity	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		Severe loss of visual acuity within hours or days. This is characteristic of Leber hereditary optic neuropathy.
http://purl.obolibrary.org/obo/HP_0001118	Juvenile cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A type of cataract that is not apparent at birth but that arises in childhood or adolescence.
http://purl.obolibrary.org/obo/HP_0001119	Keratoglobus	http://purl.obolibrary.org/obo/HP_0100692	Increased corneal curvature		Limbus-to-limbus corneal thinning, often greatest in the periphery, with globular protrusion of the cornea.
http://purl.obolibrary.org/obo/HP_0001120	Abnormality of corneal size	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		Any abnormality of the size or morphology of the cornea.
http://purl.obolibrary.org/obo/HP_0001125	Transient unilateral blurring of vision	http://purl.obolibrary.org/obo/HP_0000622	Blurred vision		Transient blurring of vision associated with the aura phase of migraine.
http://purl.obolibrary.org/obo/HP_0001126	Cryptophthalmos	http://purl.obolibrary.org/obo/HP_0011226	Aplasia/Hypoplasia of the eyelid		Cryptophthalmos is a condition of total absence of eyelids and the skin of forehead is continuous with that of cheek, in which the eyeball is completely concealed by the skin, which is stretched over the orbital cavity.
http://purl.obolibrary.org/obo/HP_0001128	Trichiasis	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		Inversion and rubbing of the eyelashes against the globe of the eye.
http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea.
http://purl.obolibrary.org/obo/HP_0001132	Lens subluxation	http://purl.obolibrary.org/obo/HP_0001083	Ectopia lentis		Partial dislocation of the lens of the eye.
http://purl.obolibrary.org/obo/HP_0001133	Constriction of peripheral visual field	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		An absolute or relative decrease in retinal sensitivity extending from edge (periphery) of the visual field in a concentric pattern. The visual field is the area that is perceived simultaneously by a fixating eye.
http://purl.obolibrary.org/obo/HP_0001134	Anterior polar cataract	http://purl.obolibrary.org/obo/HP_0010696	Polar cataract		A polar cataract that affects the anterior pole of the lens.
http://purl.obolibrary.org/obo/HP_0001136	Retinal arteriolar tortuosity	http://purl.obolibrary.org/obo/HP_0012841	Retinal vascular tortuosity		The presence of an increased number of twists and turns of the retinal arterioles.
http://purl.obolibrary.org/obo/HP_0001137	Alternating esotropia	http://purl.obolibrary.org/obo/HP_0000565	Esotropia		Esotropia in which either eye may be used for fixation.
http://purl.obolibrary.org/obo/HP_0001139	Chorioretinal scalloped atrophy	http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology		Well-defined, pale patches in the fundus.
http://purl.obolibrary.org/obo/HP_0001140	Limbal dermoid	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		A benign tumor typically found at the junction of the cornea and sclera (limbal epibullar dermoid).
http://purl.obolibrary.org/obo/HP_0001141	Severely reduced visual acuity	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		Severe reduction of the ability to see. On the 6m visual acuity scale, severe reduction is defined as less than 6/60 but at least 3/60. On the 20ft visual acuity scale, severe reduction is defined as less than 20/200 but at least 20/400. On the decimal visual acuity scale, severe reduction is defined as less than 0.1 but at least 0.05.
http://purl.obolibrary.org/obo/HP_0001142	Lenticonus	http://purl.obolibrary.org/obo/HP_0011526	Abnormality of lens shape		A conical projection of the anterior or posterior surface of the lens, occurring as a developmental anomaly.
http://purl.obolibrary.org/obo/HP_0001144	Orbital cyst	http://purl.obolibrary.org/obo/HP_0000315	Abnormality of the orbital region		Presence of a cyst in the region of the periorbital tissues. Orbital cysts can be derived from epithelial or glandular tissue within or surrounding the orbit (lacrimal glands, salivary glands, conjunctival, oral, nasal, or sinus epithelium).
http://purl.obolibrary.org/obo/HP_0001147	Retinal exudate	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Yellow-white intraretinal deposits in the retina typically associated with damaged inner blood-retina barrier and exudation of serous fluid and lipids from the retinal microvasculature.
http://purl.obolibrary.org/obo/HP_0001149	Lattice corneal dystrophy	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		The presence of fine, branching linear opacities in Bowman's layer in the central area that may spread to the periphery in the clinical course. The deep corneal stroma may be involved but the process does not reach Descemet's membrane. Recurrent corneal erosion may occur. Histologic examination reveals amyloid deposits in the collagen fibers of the cornea.
http://purl.obolibrary.org/obo/HP_0001151	Impaired horizontal smooth pursuit	http://purl.obolibrary.org/obo/HP_0007772	Impaired smooth pursuit		An abnormality of ocular smooth pursuit characterized by an impairment of the ability to track horizontally moving objects.
http://purl.obolibrary.org/obo/HP_0001152	Saccadic smooth pursuit interruptions	http://purl.obolibrary.org/obo/HP_0000617	Abnormality of ocular smooth pursuit		An abnormality of tracking eye movements in which smooth pursuit is interrupted by an abnormally high number of saccadic movements.
http://purl.obolibrary.org/obo/HP_0001153	Septate vagina	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		The presence of a vaginal septum, thereby creating a vaginal duplication. The septum is longitudinal in the majority of cases.
http://purl.obolibrary.org/obo/HP_0001155	Abnormality of the hand	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		An abnormality affecting one or both hands.
http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly	http://purl.obolibrary.org/obo/HP_0011927	Short digit		Digits that appear disproportionately short compared to the hand/foot. The word brachydactyly is used here to describe a series distinct patterns of shortened digits (brachydactyly types A-E). This is the sense used here.
http://purl.obolibrary.org/obo/HP_0001161	Hand polydactyly	http://purl.obolibrary.org/obo/HP_0010442	Polydactyly		A kind of polydactyly characterized by the presence of a supernumerary finger or fingers.
http://purl.obolibrary.org/obo/HP_0001162	Postaxial hand polydactyly	http://purl.obolibrary.org/obo/HP_0004207	Abnormal 5th finger morphology		Supernumerary digits located at the ulnar side of the hand (that is, on the side with the fifth finger).
http://purl.obolibrary.org/obo/HP_0001166	Arachnodactyly	http://purl.obolibrary.org/obo/HP_0100807	Long fingers		Abnormally long and slender fingers (spider fingers).
http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		An anomaly of a finger.
http://purl.obolibrary.org/obo/HP_0001169	Broad palm	http://purl.obolibrary.org/obo/HP_0100871	Abnormal palm morphology		For children from birth to 4 years of age the palm width is more than 2 SD above the mean; for children from 4 to 16 years of age the palm width is above the 95th centile; or, the width of the palm appears disproportionately wide for the length.
http://purl.obolibrary.org/obo/HP_0001171	Split hand	http://purl.obolibrary.org/obo/HP_0100257	Ectrodactyly		A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middle fingers as far as oligo- or monodactyl hands.
http://purl.obolibrary.org/obo/HP_0001172	Abnormal thumb morphology	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		An abnormal structure of the first digit of the hand.
http://purl.obolibrary.org/obo/HP_0001177	Preaxial hand polydactyly	http://purl.obolibrary.org/obo/HP_0100258	Preaxial polydactyly		Supernumerary digits located at the radial side of the hand. Polydactyly (supernumerary digits) involving the thumb occurs in many distinct forms of high variability and severity. Ranging from fleshy nubbins over varying degrees of partial duplication/splitting to completely duplicated or even triplicated thumbs or preaxial (on the radial side of the hand) supernumerary digits.
http://purl.obolibrary.org/obo/HP_0001178	Ulnar claw	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		An abnormal hand position characterized by hyperextension of the fourth and fifth fingers at the metacarpophalangeal joints and flexion of the interphalangeal joints of the same fingers such that they are curled towards the palm.
http://purl.obolibrary.org/obo/HP_0001181	Adducted thumb	http://purl.obolibrary.org/obo/HP_0001172	Abnormal thumb morphology		In the resting position, the tip of the thumb is on, or near, the palm, close to the base of the fourth or fifth finger.
http://purl.obolibrary.org/obo/HP_0001182	Tapered finger	http://purl.obolibrary.org/obo/HP_0100807	Long fingers		The gradual reduction in girth of the finger from proximal to distal.
http://purl.obolibrary.org/obo/HP_0001187	Hyperextensibility of the finger joints	http://purl.obolibrary.org/obo/HP_0006094	Finger joint hypermobility		The ability of the finger joints to move beyond their normal range of motion.
http://purl.obolibrary.org/obo/HP_0001188	Hand clenching	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		An abnormal hand posture in which the hands are clenched to fists. All digits held completely flexed at the metacarpophalangeal and interphalangeal joints. In prenatal sonography of the fetal clenched hand, the index finger overlaps a clenched fist formed by the other digits. The proximal interphalangeal articulation of the index finger is flexed and ulnarly deviated, and the thumb is adducted.
http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		An abnormality affecting the carpal bones of the wrist (scaphoid, lunate, triquetral, pisiform, trapezium, trapezoid, capitate, hamate).
http://purl.obolibrary.org/obo/HP_0001194	Abnormalities of placenta or umbilical cord	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		An abnormality of the placenta (the organ that connects the developing fetus to the uterine wall) or of the umbilical cord (the cord that connects the fetus to the placenta).
http://purl.obolibrary.org/obo/HP_0001195	Single umbilical artery	http://purl.obolibrary.org/obo/HP_0011425	Fetal ultrasound soft marker		Single umbilical artery (SUA) is the absence of one of the two umbilical arteries surrounding the fetal bladder and in the fetal umbilical cord.
http://purl.obolibrary.org/obo/HP_0001196	Short umbilical cord	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Decreased length of the umbilical cord.
http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities.
http://purl.obolibrary.org/obo/HP_0001199	Triphalangeal thumb	http://purl.obolibrary.org/obo/HP_0009602	Abnormality of thumb phalanx		A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb.
http://purl.obolibrary.org/obo/HP_0001204	Distal finger symphalangism	http://purl.obolibrary.org/obo/HP_0100263	Distal symphalangism		The term distal symphalangism refers to a bony fusion of the distal and middle phalanges of the digits of the hand, in other words the distal interphalangeal joint (DIJ) is missing which can be seen either on x-rays or as an absence of the distal interphalangeal finger creases.
http://purl.obolibrary.org/obo/HP_0001211	Abnormal fingertip morphology	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		An abnormal structure of the tip (end) of a finger.
http://purl.obolibrary.org/obo/HP_0001212	Prominent fingertip pads	http://purl.obolibrary.org/obo/HP_0011298	Prominent digit pad		A soft tissue prominence of the ventral aspects of the fingertips. The term "persistent fetal fingertip pads" is often used as a synonym, but should better not be used because it implies knowledge of history of the patient which often does not exist.
http://purl.obolibrary.org/obo/HP_0001215	Camptodactyly of 2nd-5th fingers	http://purl.obolibrary.org/obo/HP_0100490	Camptodactyly of finger		The distal interphalangeal joint and/or the proximal interphalangeal joint of the second to fifth fingers cannot be extended to 180 degrees by either active or passive extension.
http://purl.obolibrary.org/obo/HP_0001216	Delayed ossification of carpal bones	http://purl.obolibrary.org/obo/HP_0006257	Abnormality of carpal bone ossification		Ossification of carpal bones occurs later than age-adjusted norms.
http://purl.obolibrary.org/obo/HP_0001217	Clubbing	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		Broadening of the soft tissues (non-edematous swelling of soft tissues) of the digital tips in all dimensions associated with an increased longitudinal and lateral curvature of the nails.
http://purl.obolibrary.org/obo/HP_0001218	Autoamputation	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		Auto-amputation is the spontaneous detachment of an appendage from the body due to long standing pathology.
http://purl.obolibrary.org/obo/HP_0001220	Interphalangeal joint contracture of finger	http://purl.obolibrary.org/obo/HP_0012785	Flexion contracture of finger		Chronic loss of joint motion in an interphalangeal joint of a finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0001222	Spatulate thumbs	http://purl.obolibrary.org/obo/HP_0011304	Broad thumb		Spoon-shaped, broad thumbs.
http://purl.obolibrary.org/obo/HP_0001223	Pointed proximal second through fifth metacarpals	http://purl.obolibrary.org/obo/HP_0006119	Proximal tapering of metacarpals		All of the metacarpal bones of the hand have a pointed proximal appearance.
http://purl.obolibrary.org/obo/HP_0001227	Abnormality of the thenar eminence	http://purl.obolibrary.org/obo/HP_0001421	Abnormality of the musculature of the hand		An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb.
http://purl.obolibrary.org/obo/HP_0001230	Broad metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Abnormally broad metacarpal bones.
http://purl.obolibrary.org/obo/HP_0001231	Abnormal fingernail morphology	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		An abnormality of the fingernails.
http://purl.obolibrary.org/obo/HP_0001232	Nail bed telangiectasia	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Telangiectases in the area of the nails.
http://purl.obolibrary.org/obo/HP_0001233	2-3 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the second to the third fingers that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0001234	Hitchhiker thumb	http://purl.obolibrary.org/obo/HP_0009617	Abnormality of the distal phalanx of the thumb		With the hand relaxed and the thumb in the plane of the palm, the axis of the thumb forms an angle of at least 90 degrees with the long axis of the hand.
http://purl.obolibrary.org/obo/HP_0001238	Slender finger	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Fingers that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual.
http://purl.obolibrary.org/obo/HP_0001239	Wrist flexion contracture	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		A chronic loss of wrist joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevent normal movement of the joints of the wrist.
http://purl.obolibrary.org/obo/HP_0001245	Small thenar eminence	http://purl.obolibrary.org/obo/HP_0001227	Abnormality of the thenar eminence		Underdevelopment of the thenar eminence with reduced palmar soft tissue mass surrounding the base of the thumb.
http://purl.obolibrary.org/obo/HP_0001248	Short tubular bones of the hand	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		Decreased length of the tubular bones of the hand, that is, the phalanges and metacarpals.
http://purl.obolibrary.org/obo/HP_0001251	Ataxia	http://purl.obolibrary.org/obo/HP_0011443	Abnormality of coordination		Ataxia refers to impaired coordination of voluntary muscle movement. Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- or overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly).
http://purl.obolibrary.org/obo/HP_0001256	Mild intellectual disability	http://purl.obolibrary.org/obo/HP_0001249	Intellectual disability		Mild intellectual disability (ID) is defined as a type of ID characterized by mildly sub-average adaptive functioning and intellectual functioning, with an intelligence quotient (IQ) the range of 50-69.
http://purl.obolibrary.org/obo/HP_0001257	Spasticity	http://purl.obolibrary.org/obo/HP_0001276	Hypertonia		A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes.
http://purl.obolibrary.org/obo/HP_0001258	Spastic paraplegia	http://purl.obolibrary.org/obo/HP_0010550	Paraplegia		Complete loss of the ability to move the lower limbs accompanied by spasticity of the lower limbs.
http://purl.obolibrary.org/obo/HP_0001263	Global developmental delay	http://purl.obolibrary.org/obo/HP_0012758	Neurodevelopmental delay		A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.
http://purl.obolibrary.org/obo/HP_0001264	Spastic diplegia	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Spasticity (neuromuscular hypertonia) primarily in the muscles of the legs, hips, and pelvis.
http://purl.obolibrary.org/obo/HP_0001265	Hyporeflexia	http://purl.obolibrary.org/obo/HP_0001315	Diminished deep tendon reflex		Reduction of neurologic reflexes such as the knee-jerk reaction.
http://purl.obolibrary.org/obo/HP_0001266	Choreoathetosis	http://purl.obolibrary.org/obo/HP_0002305	Athetosis		Involuntary movements characterized by both athetosis (inability to sustain muscles in a fixed position) and chorea (widespread jerky arrhythmic movements).
http://purl.obolibrary.org/obo/HP_0001268	Mental deterioration	http://purl.obolibrary.org/obo/HP_0100543	Cognitive impairment		Loss of previously present mental abilities, generally in adults.
http://purl.obolibrary.org/obo/HP_0001270	Motor delay	http://purl.obolibrary.org/obo/HP_0012758	Neurodevelopmental delay		A type of Developmental delay characterized by a delay in acquiring motor skills.
http://purl.obolibrary.org/obo/HP_0001271	Polyneuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		A generalized disorder of peripheral nerves.
http://purl.obolibrary.org/obo/HP_0001272	Cerebellar atrophy	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		Cerebellar atrophy is defined as a cerebellum with initially normal structures, in a posterior fossa with normal size, which displays enlarged fissures (interfolial spaces) in comparison to the foliae secondary to loss of tissue. Cerebellar atrophy implies irreversible loss of tissue and result from an ongoing progressive disease until a final stage is reached or a single injury, e.g. an intoxication or infectious event.
http://purl.obolibrary.org/obo/HP_0001273	Abnormal corpus callosum morphology	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		Abnormality of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0001274	Agenesis of corpus callosum	http://purl.obolibrary.org/obo/HP_0007370	Aplasia/Hypoplasia of the corpus callosum		Absence of the corpus callosum as a result of the failure of the corpus callosum to develop, which can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline.
http://purl.obolibrary.org/obo/HP_0001278	Orthostatic hypotension	http://purl.obolibrary.org/obo/HP_0002615	Hypotension		A form of hypotension characterized by a sudden fall in blood pressure that occurs when a person assumes a standing position.
http://purl.obolibrary.org/obo/HP_0001279	Syncope	http://purl.obolibrary.org/obo/HP_0007185	Loss of consciousness		A transient loss of consciousness (i.e., characterized by a rapid onset, a short duration, and a spontaneous and complete recovery) due to cerebral hypoperfusion.
http://purl.obolibrary.org/obo/HP_0001281	Tetany	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		A condition characterized by intermittent involuntary contraction of muscles (spasms) related to hypocalcemia or occasionally magnesium deficiency.
http://purl.obolibrary.org/obo/HP_0001283	Bulbar palsy	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia.
http://purl.obolibrary.org/obo/HP_0001284	Areflexia	http://purl.obolibrary.org/obo/HP_0001315	Diminished deep tendon reflex		Absence of neurologic reflexes such as the knee-jerk reaction.
http://purl.obolibrary.org/obo/HP_0001285	Spastic tetraparesis	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Spastic weakness affecting all four limbs.
http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		The term gait disturbance can refer to any disruption of the ability to walk.
http://purl.obolibrary.org/obo/HP_0001290	Generalized hypotonia	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		Generalized muscular hypotonia (abnormally low muscle tone).
http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Structural abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.
http://purl.obolibrary.org/obo/HP_0001297	Stroke	http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology		Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to the brain.
http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state.
http://purl.obolibrary.org/obo/HP_0001300	Parkinsonism	http://purl.obolibrary.org/obo/HP_0002071	Abnormality of extrapyramidal motor function		Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.
http://purl.obolibrary.org/obo/HP_0001302	Pachygyria	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		Pachygyria is a malformation of cortical development with abnormally wide gyri with sulci 1,5-3 cm apart and abnormally thick cortex measuring more than 5 mm (radiological definition). See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly.
http://purl.obolibrary.org/obo/HP_0001304	Torsion dystonia	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		Sustained involuntary muscle contractions that produce twisting and repetitive movements of the body.
http://purl.obolibrary.org/obo/HP_0001305	Dandy-Walker malformation	http://purl.obolibrary.org/obo/HP_0005445	Enlarged posterior fossa		A congenital brain malformation typically characterized by incomplete formation of the cerebellar vermis, dilation of the fourth ventricle, and enlargement of the posterior fossa. In layman's terms, Dandy Walker malformation is a cyst in the cerebellum (typically symmetrical) that is involved with the fourth ventricle. This may interfere with the ability to drain cerebrospinal fluid from the brain, resulting in hydrocephalus. Dandy Walker cysts are formed during early embryonic development, while the brain forms. The cyst in the cerebellum typically has several blood vessels running through it connecting to the brain, thereby prohibiting surgical removal.
http://purl.obolibrary.org/obo/HP_0001308	Tongue fasciculations	http://purl.obolibrary.org/obo/HP_0030810	Abnormal tongue physiology		Fasciculations or fibrillation affecting the tongue muscle.
http://purl.obolibrary.org/obo/HP_0001310	Dysmetria	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		A type of ataxia characterized by the inability to carry out movements with the correct range and motion across the plane of more than one joint related to incorrect estimation of the distances required for targeted movements.
http://purl.obolibrary.org/obo/HP_0001311	Abnormal nervous system electrophysiology	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An abnormality of the function of the electrical signals with which nerve cells communicate with each other or with muscles as measured by electrophysiological investigations.
http://purl.obolibrary.org/obo/HP_0001312	Giant somatosensory evoked potentials	http://purl.obolibrary.org/obo/HP_0007377	Abnormality of somatosensory evoked potentials		An abnormal enlargement (i.e. increase in measured voltage) of somatosensory evoked potentials.
http://purl.obolibrary.org/obo/HP_0001315	Diminished deep tendon reflex	http://purl.obolibrary.org/obo/HP_0031826	Abnormal reflex		A reduction (hyporeflexia) or complete absence (areflexia) of the involuntary muscle contraction normally elicited by a reflex stimulus, such as tapping a deep tendon.
http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology	http://purl.obolibrary.org/obo/HP_0011283	Abnormal metencephalon morphology		Any structural abnormality of the cerebellum.
http://purl.obolibrary.org/obo/HP_0001319	Neonatal hypotonia	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period.
http://purl.obolibrary.org/obo/HP_0001320	Cerebellar vermis hypoplasia	http://purl.obolibrary.org/obo/HP_0006817	Aplasia/Hypoplasia of the cerebellar vermis		Underdevelopment of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0001321	Cerebellar hypoplasia	http://purl.obolibrary.org/obo/HP_0007360	Aplasia/Hypoplasia of the cerebellum		Cerebellar hypoplasia is a descriptive term implying a cerebellum with a reduced volume, but a normal shape and is stable over time.
http://purl.obolibrary.org/obo/HP_0001325	Hypoglycemic coma	http://purl.obolibrary.org/obo/HP_0001259	Coma		Coma induced by low blood sugar.
http://purl.obolibrary.org/obo/HP_0001326	EEG with irregular generalized spike and wave complexes	http://purl.obolibrary.org/obo/HP_0010850	EEG with spike-wave complexes		EEG shows spikes (<80 ms) and waves, which are recorded over the entire scalp and do not have a specific frequency.
http://purl.obolibrary.org/obo/HP_0001327	Photosensitive myoclonic seizure	http://purl.obolibrary.org/obo/HP_0020216	Visually-induced seizure		Generalised myoclonic seizure provoked by flashing or flickering light.
http://purl.obolibrary.org/obo/HP_0001328	Specific learning disability	http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental abnormality		Impairment of certain skills such as reading or writing, coordination, self-control, or attention that interfere with the ability to learn. The impairment is not related to a global deficiency of intelligence.
http://purl.obolibrary.org/obo/HP_0001331	Absent septum pellucidum	http://purl.obolibrary.org/obo/HP_0007375	Abnormal septum pellucidum morphology		Absence of the septum pellucidum (meaning translucent wall in Latin - SP), also known as the ventricle of Sylvius. The septum pellucidum is a thin, triangular double membrane separating the frontal horns of the right and left lateral ventricles of the brain. It extends between the anterior portion of the corpus callosum, and the body of the fornix and its width varies from 1.5 to 3.0 mm.
http://purl.obolibrary.org/obo/HP_0001332	Dystonia	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		An abnormally increased muscular tone that causes fixed abnormal postures. There is a slow, intermittent twisting motion that leads to exaggerated turning and posture of the extremities and trunk.
http://purl.obolibrary.org/obo/HP_0001334	Communicating hydrocephalus	http://purl.obolibrary.org/obo/HP_0000238	Hydrocephalus		A form of hydrocephalus in which there is no visible obstruction to the flow of the cerebrospinal fluid between the ventricles and subarachnoid space.
http://purl.obolibrary.org/obo/HP_0001335	Bimanual synkinesia	http://purl.obolibrary.org/obo/HP_0034980	Synkinesis		Involuntary movements of one hand that accompany and mirror intentional movements of the opposite hand.
http://purl.obolibrary.org/obo/HP_0001336	Myoclonus	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements.
http://purl.obolibrary.org/obo/HP_0001337	Tremor	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		An unintentional, oscillating to-and-fro muscle movement about a joint axis.
http://purl.obolibrary.org/obo/HP_0001338	Partial agenesis of the corpus callosum	http://purl.obolibrary.org/obo/HP_0001274	Agenesis of corpus callosum		A partial failure of the development of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly	http://purl.obolibrary.org/obo/HP_0002536	Abnormal cortical gyration		A spectrum of malformations of cortical development caused by insufficient neuronal migration that subsumes the terms agyria, pachygyria and subcortical band heterotopia. See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly.
http://purl.obolibrary.org/obo/HP_0001340	Enhancement of the C-reflex	http://purl.obolibrary.org/obo/HP_0007377	Abnormality of somatosensory evoked potentials		Increase in amplitude of a long-loop response upon somatosensory evoked potential testing, representing an electrically evoked myoclonic response.
http://purl.obolibrary.org/obo/HP_0001342	Cerebral hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial hemorrhage		Hemorrhage into the parenchyma of the brain.
http://purl.obolibrary.org/obo/HP_0001343	Kernicterus	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction.
http://purl.obolibrary.org/obo/HP_0001344	Absent speech	http://purl.obolibrary.org/obo/HP_0000750	Delayed speech and language development		Complete lack of development of speech and language abilities.
http://purl.obolibrary.org/obo/HP_0001345	Psychotic mentation	http://purl.obolibrary.org/obo/HP_5200430	Abnormal psychotic pattern		A pattern of thinking and perceiving characterized by a loss of contact with reality, leading to significant changes in thoughts, perceptions, and behaviors.
http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia	http://purl.obolibrary.org/obo/HP_0031826	Abnormal reflex		Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles.
http://purl.obolibrary.org/obo/HP_0001348	Brisk reflexes	http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia		Tendon reflexes that are noticeably more active than usual (conventionally denoted 3+ on clinical examination). Brisk reflexes may or may not indicate a neurological lesion. They are distinguished from hyperreflexia by the fact that hyerreflexia is characterized by hyperactive repeating (clonic) reflexes, which are considered to be always abnormal.
http://purl.obolibrary.org/obo/HP_0001349	Facial diplegia	http://purl.obolibrary.org/obo/HP_0010628	Facial palsy		Facial diplegia refers to bilateral facial palsy (bilateral facial palsy is much rarer than unilateral facial palsy).
http://purl.obolibrary.org/obo/HP_0001350	Slurred speech	http://purl.obolibrary.org/obo/HP_0011443	Abnormality of coordination		Abnormal coordination of muscles involved in speech.
http://purl.obolibrary.org/obo/HP_0001351	Jerk-locked premyoclonus spikes	http://purl.obolibrary.org/obo/HP_0030178	Abnormality of central nervous system electrophysiology		Jerk-locked averaging (JLA) is used to record the timing and distribution of brain activity preceding brisk involuntary movements such as those observed in patients with myoclonus. JLA is capable of revealing a premyoclonus spike in the absence of paroxysmal activity in the routine EEG.
http://purl.obolibrary.org/obo/HP_0001355	Megalencephaly	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		Diffuse enlargement of the entire cerebral hemispheres leading to macrocephaly (with or without overlying cortical dysplasia).
http://purl.obolibrary.org/obo/HP_0001357	Plagiocephaly	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Asymmetric head shape, which is usually a combination of unilateral occipital flattening with ipsilateral frontal prominence, leading to rhomboid cranial shape.
http://purl.obolibrary.org/obo/HP_0001360	Holoprosencephaly	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		Holoprosencephaly is a structural anomaly of the brain in which the developing forebrain fails to divide into two separate hemispheres and ventricles.
http://purl.obolibrary.org/obo/HP_0001361	Nystagmus-induced head nodding	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		Head movements associated with nystagmus, that may represent an attempt to compensate for the involuntary eye movements and to improve vision.
http://purl.obolibrary.org/obo/HP_0001362	Calvarial skull defect	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		A localized defect in the bone of the skull resulting from abnormal embryological development. The defect is covered by normal skin. In some cases, skull x-rays have shown underlying lytic bone lesions which have closed before the age of one year.
http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join.
http://purl.obolibrary.org/obo/HP_0001371	Flexion contracture	http://purl.obolibrary.org/obo/HP_0034392	Joint contracture		A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.
http://purl.obolibrary.org/obo/HP_0001376	Limitation of joint mobility	http://purl.obolibrary.org/obo/HP_0011729	Abnormality of joint mobility		A reduction in the freedom of movement of one or more joints.
http://purl.obolibrary.org/obo/HP_0001377	Limited elbow extension	http://purl.obolibrary.org/obo/HP_0002996	Limited elbow movement		Limited ability to straighten the arm at the elbow joint.
http://purl.obolibrary.org/obo/HP_0001382	Joint hypermobility	http://purl.obolibrary.org/obo/HP_0011729	Abnormality of joint mobility		The capability that a joint (or a group of joints) has to move, passively and/or actively, beyond normal limits along physiological axes.
http://purl.obolibrary.org/obo/HP_0001384	Abnormal hip joint morphology	http://purl.obolibrary.org/obo/HP_0100491	Abnormality of lower limb joint		An abnormality of the hip joint.
http://purl.obolibrary.org/obo/HP_0001385	Hip dysplasia	http://purl.obolibrary.org/obo/HP_0003272	Abnormal hip bone morphology		The presence of developmental dysplasia of the hip.
http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the liver	http://purl.obolibrary.org/obo/HP_0002012	Abnormality of the abdominal organs		An abnormality of the liver.
http://purl.obolibrary.org/obo/HP_0001394	Cirrhosis	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.
http://purl.obolibrary.org/obo/HP_0001395	Hepatic fibrosis	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process.
http://purl.obolibrary.org/obo/HP_0001396	Cholestasis	http://purl.obolibrary.org/obo/HP_0004297	Abnormality of the biliary system		Impairment of bile flow due to obstruction in bile ducts.
http://purl.obolibrary.org/obo/HP_0001397	Hepatic steatosis	http://purl.obolibrary.org/obo/HP_0006561	Lipid accumulation in hepatocytes		Steatosis is a term used to denote lipid accumulation within hepatocytes.
http://purl.obolibrary.org/obo/HP_0001402	Hepatocellular carcinoma	http://purl.obolibrary.org/obo/HP_0002896	Neoplasm of the liver		A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver.
http://purl.obolibrary.org/obo/HP_0001403	Macrovesicular hepatic steatosis	http://purl.obolibrary.org/obo/HP_0001397	Hepatic steatosis		A form of hepatic steatosis characterized by the presence of large, lipid-laden vesicles in the affected hepatocytes.
http://purl.obolibrary.org/obo/HP_0001405	Periportal fibrosis	http://purl.obolibrary.org/obo/HP_0001395	Hepatic fibrosis		The presence of fibrosis affecting the interlobular stroma of liver.
http://purl.obolibrary.org/obo/HP_0001406	Intrahepatic cholestasis	http://purl.obolibrary.org/obo/HP_0031865	Abnormal liver physiology		Impairment of bile flow due to obstruction in the small bile ducts within the liver.
http://purl.obolibrary.org/obo/HP_0001408	Bile duct proliferation	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Proliferative changes of the bile ducts.
http://purl.obolibrary.org/obo/HP_0001409	Portal hypertension	http://purl.obolibrary.org/obo/HP_0032263	Increased blood pressure		Increased pressure in the portal vein.
http://purl.obolibrary.org/obo/HP_0001410	Decreased liver function	http://purl.obolibrary.org/obo/HP_0025155	Abnormal hepatobiliary system physiology		Reduced ability of the liver to perform its functions.
http://purl.obolibrary.org/obo/HP_0001412	Enteroviral hepatitis	http://purl.obolibrary.org/obo/HP_0006562	Viral hepatitis		Inflammation of the liver due to infection with enterovirus.
http://purl.obolibrary.org/obo/HP_0001413	Micronodular cirrhosis	http://purl.obolibrary.org/obo/HP_0001394	Cirrhosis		A type of cirrhosis characterized by the presence of small regenerative nodules.
http://purl.obolibrary.org/obo/HP_0001414	Microvesicular hepatic steatosis	http://purl.obolibrary.org/obo/HP_0001397	Hepatic steatosis		A form of hepatic steatosis characterized by the presence of small, lipid-laden vesicles in the affected hepatocytes.
http://purl.obolibrary.org/obo/HP_0001417	X-linked inheritance	http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance		A mode of inheritance that is observed for traits related to a gene encoded on the X chromosome.
http://purl.obolibrary.org/obo/HP_0001419	X-linked recessive inheritance	http://purl.obolibrary.org/obo/HP_0001417	X-linked inheritance		A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele.
http://purl.obolibrary.org/obo/HP_0001423	X-linked dominant inheritance	http://purl.obolibrary.org/obo/HP_0001417	X-linked inheritance		A mode of inheritance that is observed for dominant traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked dominant disorders tend to manifest very severely in affected males. The severity of manifestation in females may depend on the degree of skewed X inactivation.
http://purl.obolibrary.org/obo/HP_0001426	Non-Mendelian inheritance	http://purl.obolibrary.org/obo/HP_0000005	Mode of inheritance		A mode of inheritance that depends on genetic determinants in more than one gene.
http://purl.obolibrary.org/obo/HP_0001427	Mitochondrial inheritance	http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance		A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy).
http://purl.obolibrary.org/obo/HP_0001435	Abnormality of the shoulder girdle musculature	http://purl.obolibrary.org/obo/HP_0001446	Abnormality of the musculature of the upper limbs		A structural or functional anomaly of the shoulder girdle, which which connects the upper limb to the axial skeleton via the sternoclavicular joint.
http://purl.obolibrary.org/obo/HP_0001436	Abnormality of the foot musculature	http://purl.obolibrary.org/obo/HP_0001437	Abnormality of the musculature of the lower limbs		An anomaly of the musculature of foot.
http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		A structural abnormality of the abdomen ('belly'), that is, the part of the body between the pelvis and the thorax.
http://purl.obolibrary.org/obo/HP_0001442	Typified by somatic mosaicism	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic.
http://purl.obolibrary.org/obo/HP_0001450	Y-linked inheritance	http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance		A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome.
http://purl.obolibrary.org/obo/HP_0001459	1-3 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes one to three.
http://purl.obolibrary.org/obo/HP_0001460	Aplasia/Hypoplasia involving the skeletal musculature	http://purl.obolibrary.org/obo/HP_0030236	Abnormality of muscle size		Absence or underdevelopment of the musculature.
http://purl.obolibrary.org/obo/HP_0001464	Aplasia/Hypoplasia involving the shoulder musculature	http://purl.obolibrary.org/obo/HP_0001467	Aplasia/Hypoplasia involving the musculature of the upper limbs		Absence or underdevelopment of the muscles of the shoulder.
http://purl.obolibrary.org/obo/HP_0001466	Contiguous gene syndrome	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		A syndrome caused by the effects of abnormality (typically a deletion or duplication) of 2 or more adjacent genes
http://purl.obolibrary.org/obo/HP_0001467	Aplasia/Hypoplasia involving the musculature of the upper limbs	http://purl.obolibrary.org/obo/HP_0009128	Aplasia/Hypoplasia involving the musculature of the extremities		Absence or underdevelopment of the musculature of the upper limbs.
http://purl.obolibrary.org/obo/HP_0001468	Aplasia/Hypoplasia involving the musculature of the upper arm	http://purl.obolibrary.org/obo/HP_0001467	Aplasia/Hypoplasia involving the musculature of the upper limbs		Absence or underdevelopment of the muscles of the upper arm.
http://purl.obolibrary.org/obo/HP_0001470	Sex-limited expression	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Sex limitation is used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in one sex.
http://purl.obolibrary.org/obo/HP_0001473	Metatarsal osteolysis	http://purl.obolibrary.org/obo/HP_0009134	Osteolysis involving bones of the feet		Osteolysis involving metatarsal bones.
http://purl.obolibrary.org/obo/HP_0001474	Sclerotic scapulae	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Increased density of the bony tissue of the scapula.
http://purl.obolibrary.org/obo/HP_0001475	Male-limited expression	http://purl.obolibrary.org/obo/HP_0001470	Sex-limited expression		Used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in the male sex.
http://purl.obolibrary.org/obo/HP_0001476	Delayed closure of the anterior fontanelle	http://purl.obolibrary.org/obo/HP_0000270	Delayed cranial suture closure		A delay in closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life.
http://purl.obolibrary.org/obo/HP_0001477	Compensatory chin elevation	http://purl.obolibrary.org/obo/HP_0031705	Compensatory head posture		A tendency to hold the chin elevated by about 20 to 30 degrees to compensate for a limitation of eye movement.
http://purl.obolibrary.org/obo/HP_0001483	Eye poking	http://purl.obolibrary.org/obo/HP_5200065	Tactile sensory seeking		Repetitive pressing, poking, and/or rubbing in the eyes.
http://purl.obolibrary.org/obo/HP_0001489	Posterior vitreous detachment	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Separation of the vitreous humor from the retina.
http://purl.obolibrary.org/obo/HP_0001491	Congenital fibrosis of extraocular muscles	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		Congenital non-progressive ophthalmoplegia with multiple extraocular muscle restrictions. Typically, there is ptosis and variable degrees of restriction of horizontal and vertical eye movements.
http://purl.obolibrary.org/obo/HP_0001492	Axenfeld anomaly	http://purl.obolibrary.org/obo/HP_0007700	Ocular anterior segment dysgenesis		Axenfeld's anomaly is a bilateral disorder characterized by a prominent, anteriorly displaced Schwalbe's line (posterior embryotoxon) and peripheral iris strands which span the anterior chamber angle to attach to Schwalbe's line.
http://purl.obolibrary.org/obo/HP_0001493	Falciform retinal fold	http://purl.obolibrary.org/obo/HP_0008052	Retinal fold		An area of the retina that is buckled so that a sector-shaped sheet of retina lies in front of the normal retina. This feature is of congenital onset.
http://purl.obolibrary.org/obo/HP_0001495	Carpal osteolysis	http://purl.obolibrary.org/obo/HP_0045039	Osteolysis involving bones of the upper limbs		Osteolysis affecting carpal bones.
http://purl.obolibrary.org/obo/HP_0001498	Carpal bone hypoplasia	http://purl.obolibrary.org/obo/HP_0006502	Aplasia/Hypoplasia involving the carpal bones		Underdevelopment of one or more carpal bones.
http://purl.obolibrary.org/obo/HP_0001500	Broad finger	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Increased width of a non-thumb digit of the hand.
http://purl.obolibrary.org/obo/HP_0001511	Intrauterine growth retardation	http://purl.obolibrary.org/obo/HP_0001510	Growth delay		An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.
http://purl.obolibrary.org/obo/HP_0001518	Small for gestational age	http://purl.obolibrary.org/obo/HP_0004325	Decreased body weight		Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age.
http://purl.obolibrary.org/obo/HP_0001519	Disproportionate tall stature	http://purl.obolibrary.org/obo/HP_0000098	Tall stature		A tall and slim body build with increased arm span to height ratio (>1.05) and a reduced upper-to-lower segment ratio (<0.85), i.e., unusually long arms and legs. The extremities as well as the hands and feet are unusually slim.
http://purl.obolibrary.org/obo/HP_0001520	Large for gestational age	http://purl.obolibrary.org/obo/HP_0004324	Increased body weight		The term large for gestational age applies to babies whose birth weight lies above the 90th percentile for that gestational age.
http://purl.obolibrary.org/obo/HP_0001522	Death in infancy	http://purl.obolibrary.org/obo/HP_0011420	Age of death		Death within the first 24 months of life.
http://purl.obolibrary.org/obo/HP_0001528	Hemihypertrophy	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		Overgrowth of only one side of the body.
http://purl.obolibrary.org/obo/HP_0001530	Mild postnatal growth retardation	http://purl.obolibrary.org/obo/HP_0008897	Postnatal growth retardation		A mild degree of slow or limited growth after birth, being between two and three standard deviations below age- and sex-related norms.
http://purl.obolibrary.org/obo/HP_0001533	Slender build	http://purl.obolibrary.org/obo/HP_0004325	Decreased body weight		Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones.
http://purl.obolibrary.org/obo/HP_0001537	Umbilical hernia	http://purl.obolibrary.org/obo/HP_0004299	Hernia of the abdominal wall		Protrusion of abdominal contents through a defect in the abdominal wall musculature around the umbilicus. Skin and subcutaneous tissue overlie the defect.
http://purl.obolibrary.org/obo/HP_0001538	Protuberant abdomen	http://purl.obolibrary.org/obo/HP_0003270	Abdominal distention		A thrusting or bulging out of the abdomen.
http://purl.obolibrary.org/obo/HP_0001539	Omphalocele	http://purl.obolibrary.org/obo/HP_0004299	Hernia of the abdominal wall		A midline anterior incomplete closure of the abdominal wall in which there is herniation of the abdominal viscera into the base of the abdominal cord.
http://purl.obolibrary.org/obo/HP_0001540	Diastasis recti	http://purl.obolibrary.org/obo/HP_0010991	Abnormal morphology of the abdominal musculature		A separation of the rectus abdominis muscle into right and left halves (which are normally joined at the midline at the linea alba).
http://purl.obolibrary.org/obo/HP_0001541	Ascites	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		Accumulation of fluid in the peritoneal cavity (between the layers of the peritoneum that lines the abdomen).
http://purl.obolibrary.org/obo/HP_0001543	Gastroschisis	http://purl.obolibrary.org/obo/HP_0010866	Abdominal wall defect		A type of congenital ventral incomplete closure of the abdominal wall in which the intestines and sometimes other organs extend freely into the amniotic fluid space through a small opening in the abdomen, usually to the right of the umbilicus.
http://purl.obolibrary.org/obo/HP_0001544	Prominent umbilicus	http://purl.obolibrary.org/obo/HP_0001551	Abnormal umbilicus morphology		Abnormally prominent umbilicus (belly button).
http://purl.obolibrary.org/obo/HP_0001545	Anteriorly placed anus	http://purl.obolibrary.org/obo/HP_0004397	Ectopic anus		Anterior malposition of the anus.
http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology	http://purl.obolibrary.org/obo/HP_0000765	Abnormal thorax morphology		A morphological anomaly of the rib cage.
http://purl.obolibrary.org/obo/HP_0001551	Abnormal umbilicus morphology	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		An abnormality of the structure or appearance of the umbilicus.
http://purl.obolibrary.org/obo/HP_0001552	Barrel-shaped chest	http://purl.obolibrary.org/obo/HP_0100625	Enlarged thorax		A rounded, bulging chest that resembles the shape of a barrel. That is, there is an increased anteroposterior diameter and usually some degree of kyphosis.
http://purl.obolibrary.org/obo/HP_0001555	Asymmetry of the thorax	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		Lack of symmetry between the left and right halves of the thorax.
http://purl.obolibrary.org/obo/HP_0001557	Prenatal movement abnormality	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		An abnormality of fetal movement.
http://purl.obolibrary.org/obo/HP_0001558	Decreased fetal movement	http://purl.obolibrary.org/obo/HP_0001557	Prenatal movement abnormality		An abnormal reduction in quantity or strength of fetal movements.
http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		Abnormality of the amniotic fluid, which is the fluid contained in the amniotic sac surrounding the developing fetus.
http://purl.obolibrary.org/obo/HP_0001561	Polyhydramnios	http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid		The presence of excess amniotic fluid in the uterus during pregnancy.
http://purl.obolibrary.org/obo/HP_0001562	Oligohydramnios	http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid		Diminished amniotic fluid volume in pregnancy.
http://purl.obolibrary.org/obo/HP_0001563	Fetal polyuria	http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid		Abnormally increased production of urine by the fetus resulting in polyhydramnios.
http://purl.obolibrary.org/obo/HP_0001566	Widely-spaced maxillary central incisors	http://purl.obolibrary.org/obo/HP_0006304	Widely-spaced incisors		Increased distance between the maxillary central permanent incisor tooth.
http://purl.obolibrary.org/obo/HP_0001571	Multiple impacted teeth	http://purl.obolibrary.org/obo/HP_0011079	Impacted tooth		The presence of multiple impacted teeth.
http://purl.obolibrary.org/obo/HP_0001572	Macrodontia	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		Increased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD above mean for age. Alternatively, an apparently increased maximum width of the tooth.
http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the integument	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the integument, which consists of the skin and the superficial fascia.
http://purl.obolibrary.org/obo/HP_0001579	Primary hypercortisolism	http://purl.obolibrary.org/obo/HP_0003118	Increased circulating cortisol level		Hypercortisolemia associated with a primary defect of the adrenal gland leading to overproduction of cortisol.
http://purl.obolibrary.org/obo/HP_0001581	Recurrent skin infections	http://purl.obolibrary.org/obo/HP_0032162	Unusual skin infection		Infections of the skin that happen multiple times.
http://purl.obolibrary.org/obo/HP_0001582	Redundant skin	http://purl.obolibrary.org/obo/HP_0000973	Cutis laxa		Loose and sagging skin often associated with loss of skin elasticity.
http://purl.obolibrary.org/obo/HP_0001583	Rotary nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		A form of nystagmus in which the eyeball makes rotary motions around the axis.
http://purl.obolibrary.org/obo/HP_0001586	Vesicovaginal fistula	http://purl.obolibrary.org/obo/HP_0004321	Bladder fistula		The presence of a fistula connecting the urinary bladder to the vagina.
http://purl.obolibrary.org/obo/HP_0001591	Bell-shaped thorax	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		The rib cage has the shape of a wide mouthed bell. That is, the superior portion of the rib cage is constricted, followed by a convex region, and the inferior portion of the rib cage expands again to have a large diameter.
http://purl.obolibrary.org/obo/HP_0001592	Selective tooth agenesis	http://purl.obolibrary.org/obo/HP_0009804	Tooth agenesis		Agenesis specifically affecting one of the classes incisor, premolar, or molar.
http://purl.obolibrary.org/obo/HP_0001593	Maxillary lateral incisor microdontia	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		Decreased size of the maxillary permanent incisor.
http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology	http://purl.obolibrary.org/obo/HP_0011138	Abnormal skin adnexa morphology		An abnormality of the hair.
http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology	http://purl.obolibrary.org/obo/HP_0011138	Abnormal skin adnexa morphology		Abnormal structure or appearance of the nail.
http://purl.obolibrary.org/obo/HP_0001598	Concave nail	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		The natural longitudinal (posterodistal) convex arch is not present or is inverted.
http://purl.obolibrary.org/obo/HP_0001600	Abnormality of the larynx	http://purl.obolibrary.org/obo/HP_0002087	Abnormality of the upper respiratory tract		An abnormality of the larynx.
http://purl.obolibrary.org/obo/HP_0001601	Laryngomalacia	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Laryngomalacia is a congenital abnormality of the laryngeal cartilage in which the cartilage is floppy and prolapses over the larynx during inspiration.
http://purl.obolibrary.org/obo/HP_0001602	Laryngeal stenosis	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Stricture or narrowing of the larynx that may be associated with symptoms of respiratory difficulty depending on the degree of laryngeal narrowing.
http://purl.obolibrary.org/obo/HP_0001604	Vocal cord paresis	http://purl.obolibrary.org/obo/HP_0001605	Vocal cord paralysis		Decreased strength of the vocal folds.
http://purl.obolibrary.org/obo/HP_0001605	Vocal cord paralysis	http://purl.obolibrary.org/obo/HP_0031801	Vocal cord dysfunction		A loss of the ability to move the vocal folds.
http://purl.obolibrary.org/obo/HP_0001611	Hypernasal speech	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		A type of speech characterized by the presence of an abnormally increased nasal airflow during speech associated with structural abnormality of the nasal passages.
http://purl.obolibrary.org/obo/HP_0001620	Abnormally high-pitched voice	http://purl.obolibrary.org/obo/HP_5200005	Abnormal pitch		A persistent (minutes to hours) abnormal increase in the pitch (frequency) of the voice for the context or social situation or significantly different from baseline of the individual.
http://purl.obolibrary.org/obo/HP_0001621	Weak voice	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		Reduced intensity (volume) of speech.
http://purl.obolibrary.org/obo/HP_0001622	Premature birth	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		The birth of a baby of less than 37 weeks of gestational age.
http://purl.obolibrary.org/obo/HP_0001623	Breech presentation	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first.
http://purl.obolibrary.org/obo/HP_0001626	Abnormality of the cardiovascular system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		Any abnormality of the cardiovascular system.
http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology	http://purl.obolibrary.org/obo/HP_0030680	Abnormal cardiovascular system morphology		Any structural anomaly of the heart.
http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect	http://purl.obolibrary.org/obo/HP_0010438	Abnormal ventricular septum morphology		A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum.
http://purl.obolibrary.org/obo/HP_0001631	Atrial septal defect	http://purl.obolibrary.org/obo/HP_0011994	Abnormal atrial septum morphology		Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum.
http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology	http://purl.obolibrary.org/obo/HP_0006705	Abnormal atrioventricular valve morphology		Any structural anomaly of the mitral valve.
http://purl.obolibrary.org/obo/HP_0001634	Mitral valve prolapse	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		One or both of the leaflets (cusps) of the mitral valve bulges back into the left atrium upon contraction of the left ventricle.
http://purl.obolibrary.org/obo/HP_0001635	Congestive heart failure	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
http://purl.obolibrary.org/obo/HP_0001636	Tetralogy of Fallot	http://purl.obolibrary.org/obo/HP_0001710	Conotruncal defect		A congenital cardiac malformation comprising pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy. The diagnosis of TOF is made if at least three of the four above mentioned features are present.
http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		A structural anomaly of the muscle layer of the heart wall.
http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		A myocardial disorder in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality.
http://purl.obolibrary.org/obo/HP_0001639	Hypertrophic cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy		Hypertrophic cardiomyopathy (HCM) is defined by the presence of increased ventricular wall thickness or mass in the absence of loading conditions (hypertension, valve disease) sufficient to cause the observed abnormality.
http://purl.obolibrary.org/obo/HP_0001640	Cardiomegaly	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Increased size of the heart, clinically defined as an increased transverse diameter of the cardiac silhouette that is greater than or equal to 50% of the transverse diameter of the chest (increased cardiothoracic ratio) on a posterior-anterior projection of a chest radiograph or a computed tomography.
http://purl.obolibrary.org/obo/HP_0001641	Abnormal pulmonary valve morphology	http://purl.obolibrary.org/obo/HP_0001654	Abnormal heart valve morphology		Any structural abnormality of the pulmonary valve.
http://purl.obolibrary.org/obo/HP_0001642	Pulmonic stenosis	http://purl.obolibrary.org/obo/HP_0031654	Abnormal pulmonary valve physiology		A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis), below the pulmonary valve (infundibular stenosis), or above the pulmonary valve (supravalvar stenosis).
http://purl.obolibrary.org/obo/HP_0001643	Patent ductus arteriosus	http://purl.obolibrary.org/obo/HP_0011603	Congenital malformation of the great arteries		In utero, the ductus arteriosus (DA) serves to divert ventricular output away from the lungs and toward the placenta by connecting the main pulmonary artery to the descending aorta. A patent ductus arteriosus (PDA) in the first 3 days of life is a physiologic shunt in healthy term and preterm newborn infants, and normally is substantially closed within about 24 hours after bith and completely closed after about three weeks. Failure of physiologcal closure is referred to a persistent or patent ductus arteriosus (PDA). Depending on the degree of left-to-right shunting, PDA can have clinical consequences.
http://purl.obolibrary.org/obo/HP_0001644	Dilated cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy		Dilated cardiomyopathy (DCM) is defined by the presence of left ventricular dilatation and left ventricular systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease) or coronary artery disease sufficient to cause global systolic impairment. Right ventricular dilation and dysfunction may be present but are not necessary for the diagnosis.
http://purl.obolibrary.org/obo/HP_0001645	Sudden cardiac death	http://purl.obolibrary.org/obo/HP_0001699	Sudden death		The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset).
http://purl.obolibrary.org/obo/HP_0001646	Abnormal aortic valve morphology	http://purl.obolibrary.org/obo/HP_0001654	Abnormal heart valve morphology		Any abnormality of the aortic valve.
http://purl.obolibrary.org/obo/HP_0001647	Bicuspid aortic valve	http://purl.obolibrary.org/obo/HP_0031567	Abnormal aortic valve cusp morphology		The presence of an aortic valve with two instead of the normal three cusps (flaps). Bicuspid aortic valvue is a malformation of a commissure (small space between the attachment of each cusp to the aortic wall) and the adjacent parts of the two corresponding cusps forming a raphe (the fused area of the two underdeveloped cusps turning into a malformed commissure between both cusps; the raphe is a fibrous ridge that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps).
http://purl.obolibrary.org/obo/HP_0001648	Cor pulmonale	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle.
http://purl.obolibrary.org/obo/HP_0001651	Dextrocardia	http://purl.obolibrary.org/obo/HP_0004307	Abnormal anatomic location of the heart		The heart is located in the right hand sided hemithorax. That is, there is a left-right reversal (or "mirror reflection") of the anatomical location of the heart in which the heart is locate on the right side instead of the left.
http://purl.obolibrary.org/obo/HP_0001653	Mitral regurgitation	http://purl.obolibrary.org/obo/HP_0031481	Abnormal mitral valve physiology		An abnormality of the mitral valve characterized by insufficiency or incompetence of the mitral valve resulting in retrograde leaking of blood through the mitral valve upon ventricular contraction.
http://purl.obolibrary.org/obo/HP_0001654	Abnormal heart valve morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Any structural abnormality of a cardiac valve.
http://purl.obolibrary.org/obo/HP_0001655	Patent foramen ovale	http://purl.obolibrary.org/obo/HP_0011994	Abnormal atrial septum morphology		Failure of the foramen ovale to seal postnatally, leaving a potential conduit between the left and right cardiac atria.
http://purl.obolibrary.org/obo/HP_0001657	Prolonged QT interval	http://purl.obolibrary.org/obo/HP_0031547	Abnormal QT interval		Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).
http://purl.obolibrary.org/obo/HP_0001658	Myocardial infarction	http://purl.obolibrary.org/obo/HP_0033678	Acute coronary syndrome		Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.
http://purl.obolibrary.org/obo/HP_0001659	Aortic regurgitation	http://purl.obolibrary.org/obo/HP_0031652	Abnormal aortic valve physiology		An insufficiency of the aortic valve, leading to regurgitation (backward flow) of blood from the aorta into the left ventricle.
http://purl.obolibrary.org/obo/HP_0001660	Truncus arteriosus	http://purl.obolibrary.org/obo/HP_0011603	Congenital malformation of the great arteries		A single arterial trunk arises from the cardiac mass. The pulmonary arteries, aorta and coronary arteries arise from this single trunk with no evidence of another outflow tract.
http://purl.obolibrary.org/obo/HP_0001662	Bradycardia	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		A slower than normal heart rate (in adults, slower than 60 beats per minute).
http://purl.obolibrary.org/obo/HP_0001663	Ventricular fibrillation	http://purl.obolibrary.org/obo/HP_0004308	Ventricular arrhythmia		Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations.
http://purl.obolibrary.org/obo/HP_0001664	Torsade de pointes	http://purl.obolibrary.org/obo/HP_0004308	Ventricular arrhythmia		A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG.
http://purl.obolibrary.org/obo/HP_0001667	Right ventricular hypertrophy	http://purl.obolibrary.org/obo/HP_0001714	Ventricular hypertrophy		In this case the right ventricle is more muscular than normal, causing a characteristic boot-shaped (coeur-en-sabot) appearance as seen on anterior- posterior chest x-rays. Right ventricular hypertrophy is commonly associated with any form of right ventricular outflow obstruction or pulmonary hypertension, which may in turn owe its origin to left-sided disease. The echocardiographic signs are thickening of the anterior right ventricular wall and the septum. Cavity size is usually normal, or slightly enlarged. In many cases there is associated volume overload present due to tricuspid regurgitation, in the absence of this, septal motion is normal.
http://purl.obolibrary.org/obo/HP_0001669	Transposition of the great arteries	http://purl.obolibrary.org/obo/HP_0011603	Congenital malformation of the great arteries		A complex congenital heart defect in which the aorta arises from the morphologic right ventricle and the pulmonary artery arises from the morphologic left ventricle.
http://purl.obolibrary.org/obo/HP_0001670	Asymmetric septal hypertrophy	http://purl.obolibrary.org/obo/HP_0001639	Hypertrophic cardiomyopathy		Hypertrophic cardiomyopathy with an asymmetrical pattern of hypertrophy, with a predilection for the interventricular septum and myocyte disarray.
http://purl.obolibrary.org/obo/HP_0001671	Abnormal cardiac septum morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		An anomaly of the intra-atrial or intraventricular septum.
http://purl.obolibrary.org/obo/HP_0001674	Complete atrioventricular canal defect	http://purl.obolibrary.org/obo/HP_0006695	Atrioventricular canal defect		A congenital heart defect characterized by a specific combination of heart defects with a common atrioventricular valve, primum atrial septal defect and inlet ventricular septal defect.
http://purl.obolibrary.org/obo/HP_0001677	Coronary artery atherosclerosis	http://purl.obolibrary.org/obo/HP_0100545	Arterial stenosis		Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia.
http://purl.obolibrary.org/obo/HP_0001678	Atrioventricular block	http://purl.obolibrary.org/obo/HP_0012722	Heart block		Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles.
http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology	http://purl.obolibrary.org/obo/HP_0030962	Abnormal morphology of the great vessels		An abnormality of the aorta.
http://purl.obolibrary.org/obo/HP_0001680	Coarctation of aorta	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Coarctation of the aorta is a narrowing or constriction of a segment of the aorta.
http://purl.obolibrary.org/obo/HP_0001681	Angina pectoris	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia.
http://purl.obolibrary.org/obo/HP_0001682	Subvalvular aortic stenosis	http://purl.obolibrary.org/obo/HP_0011103	Abnormal left ventricular outflow tract morphology		A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve.
http://purl.obolibrary.org/obo/HP_0001683	Ectopia cordis	http://purl.obolibrary.org/obo/HP_0004307	Abnormal anatomic location of the heart		Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and through the defect in the ventral wall.
http://purl.obolibrary.org/obo/HP_0001684	Secundum atrial septal defect	http://purl.obolibrary.org/obo/HP_0001631	Atrial septal defect		A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum.
http://purl.obolibrary.org/obo/HP_0001685	Myocardial fibrosis	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Myocardial fibrosis is characterized by dysregulated collagen turnover (increased synthesis predominates over unchanged or decreased degradation) and excessive diffuse collagen accumulation in the interstitial and perivascular spaces as well as by phenotypically transformed fibroblasts, termed myofibroblasts.
http://purl.obolibrary.org/obo/HP_0001688	Sinus bradycardia	http://purl.obolibrary.org/obo/HP_0011702	Abnormal electrophysiology of sinoatrial node origin		Bradycardia related to a mean resting sinus rate of less than 50 beats per minute.
http://purl.obolibrary.org/obo/HP_0001691	Muscular subvalvular aortic stenosis	http://purl.obolibrary.org/obo/HP_0001682	Subvalvular aortic stenosis		A type of subvalvular aortic stenosis resulting from thickening of the musculature of the interventricular septum, which results in obstruction to blood flow through the left-ventricular outflow tract.
http://purl.obolibrary.org/obo/HP_0001692	Atrial arrhythmia	http://purl.obolibrary.org/obo/HP_0005115	Supraventricular arrhythmia		A type of supraventricular tachycardia in which the atria are the principal site of electrophysiologic disturbance.
http://purl.obolibrary.org/obo/HP_0001693	Cardiac shunt	http://purl.obolibrary.org/obo/HP_0011028	Abnormality of blood circulation		Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system.
http://purl.obolibrary.org/obo/HP_0001694	Right-to-left shunt	http://purl.obolibrary.org/obo/HP_0001693	Cardiac shunt		Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the right side of the heart to the left.
http://purl.obolibrary.org/obo/HP_0001695	Cardiac arrest	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		An abrupt loss of heart function.
http://purl.obolibrary.org/obo/HP_0001696	Situs inversus totalis	http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments		A left-right reversal (or mirror reflection) of the anatomical location of the major thoracic and abdominal organs.
http://purl.obolibrary.org/obo/HP_0001697	Abnormal pericardium morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		An abnormality of the pericardium, i.e., of the fluid filled sac that surrounds the heart and the proximal ends of the aorta, vena cava, and the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0001698	Pericardial effusion	http://purl.obolibrary.org/obo/HP_0001697	Abnormal pericardium morphology		Accumulation of fluid within the pericardium.
http://purl.obolibrary.org/obo/HP_0001699	Sudden death	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Rapid and unexpected death.
http://purl.obolibrary.org/obo/HP_0001700	Myocardial necrosis	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Irreversible damage to heart tissue (myocardium) due to lack of oxygen after a heart attack (myocardial infarction).
http://purl.obolibrary.org/obo/HP_0001701	Pericarditis	http://purl.obolibrary.org/obo/HP_0045073	Serositis		Inflammation of the sac-like covering around the heart (pericardium).
http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology	http://purl.obolibrary.org/obo/HP_0006705	Abnormal atrioventricular valve morphology		Any structural anomaly of the tricuspid valve.
http://purl.obolibrary.org/obo/HP_0001704	Tricuspid valve prolapse	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		One or more of the leaflets (cusps) of the tricuspid valve bulges back into the right atrium upon contraction of the right ventricle.
http://purl.obolibrary.org/obo/HP_0001705	Right ventricular outlet tract obstruction	http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function		An obstruction to the forward flow of blood in the outflow tract of the right ventricle.
http://purl.obolibrary.org/obo/HP_0001706	Endocardial fibroelastosis	http://purl.obolibrary.org/obo/HP_0004306	Abnormal endocardium morphology		Diffuse thickening of the ventricular endocardium and by associated myocardial dysfunction
http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		An abnormality of the right ventricle of the heart.
http://purl.obolibrary.org/obo/HP_0001708	Right ventricular failure	http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function		Reduced ability of the right ventricle to perform its function (to receive blood from the right atrium and to eject blood into the pulmonary artery), often leading to pitting peripheral edema, ascites, and hepatomegaly.
http://purl.obolibrary.org/obo/HP_0001709	Third degree atrioventricular block	http://purl.obolibrary.org/obo/HP_0001678	Atrioventricular block		Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them.
http://purl.obolibrary.org/obo/HP_0001710	Conotruncal defect	http://purl.obolibrary.org/obo/HP_0011603	Congenital malformation of the great arteries		A congenital malformation of the outflow tract of the heart. Conotruncal defects are thought to result from a disturbance of the outflow tract of the embryonic heart, and comprise truncus arteriosus, tetralogy of Fallot, interrupted aortic arch, transposition of the great arteries, and double outlet right ventricle.
http://purl.obolibrary.org/obo/HP_0001711	Abnormal left ventricle morphology	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		Any structural abnormality of the left ventricle of the heart.
http://purl.obolibrary.org/obo/HP_0001712	Left ventricular hypertrophy	http://purl.obolibrary.org/obo/HP_0001714	Ventricular hypertrophy		Enlargement or increased size of the heart left ventricle.
http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		An abnormality of a cardiac ventricle.
http://purl.obolibrary.org/obo/HP_0001714	Ventricular hypertrophy	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		Enlargement of the cardiac ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy.
http://purl.obolibrary.org/obo/HP_0001716	Wolff-Parkinson-White syndrome	http://purl.obolibrary.org/obo/HP_0004309	Ventricular preexcitation		A disorder of the cardiac conduction system of the heart characterized by ventricular preexcitation due to the presence of an abnormal accessory atrioventricular electrical conduction pathway.
http://purl.obolibrary.org/obo/HP_0001717	Coronary artery calcification	http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a coronary artery.
http://purl.obolibrary.org/obo/HP_0001718	Mitral stenosis	http://purl.obolibrary.org/obo/HP_0031481	Abnormal mitral valve physiology		An abnormal narrowing of the orifice of the mitral valve.
http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle	http://purl.obolibrary.org/obo/HP_0011723	Congenital malformation of the right heart		Double outlet right ventricle (DORV) is a type of ventriculoarterial connection in which both great vessels arise entirely or predominantly from the right ventricle.
http://purl.obolibrary.org/obo/HP_0001722	High-output congestive heart failure	http://purl.obolibrary.org/obo/HP_0001635	Congestive heart failure		A form of heart failure characterized by elevated cardiac output. This may be seen in patients with heart failure and hyperthyroidism, anemia, pregnancy, arteriovenous fistulae, and others.
http://purl.obolibrary.org/obo/HP_0001723	Restrictive cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy		Restrictive left ventricular physiology is characterized by a pattern of ventricular filling in which increased stiffness of the myocardium causes ventricular pressure to rise precipitously with only small increases in volume, defined as restrictive ventricular physiology in the presence of normal or reduced diastolic volumes (of one or both ventricles), normal or reduced systolic volumes, and normal ventricular wall thickness.
http://purl.obolibrary.org/obo/HP_0001727	Thromboembolic stroke	http://purl.obolibrary.org/obo/HP_0001907	Thromboembolism		A cerebrovascular accident (stroke) that occurs because of thromboembolism.
http://purl.obolibrary.org/obo/HP_0001730	Progressive hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A progressive form of hearing impairment.
http://purl.obolibrary.org/obo/HP_0001732	Abnormality of the pancreas	http://purl.obolibrary.org/obo/HP_0002012	Abnormality of the abdominal organs		An abnormality of the pancreas.
http://purl.obolibrary.org/obo/HP_0001734	Annular pancreas	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		A congenital anomaly in which the pancreas completely (or sometimes incompletely) encircles the second portion of duodenum and occasionally obstructs the more proximal duodenum.
http://purl.obolibrary.org/obo/HP_0001735	Acute pancreatitis	http://purl.obolibrary.org/obo/HP_0001733	Pancreatitis		A acute form of pancreatitis.
http://purl.obolibrary.org/obo/HP_0001737	Pancreatic cysts	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		A cyst of the pancreas that possess a lining of mucous epithelium.
http://purl.obolibrary.org/obo/HP_0001738	Exocrine pancreatic insufficiency	http://purl.obolibrary.org/obo/HP_0012092	Abnormality of exocrine pancreas physiology		Impaired function of the exocrine pancreas associated with a reduced ability to digest foods because of lack of digestive enzymes.
http://purl.obolibrary.org/obo/HP_0001739	Abnormal nasopharynx morphology	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		A structural anomaly of the nasopharynx.
http://purl.obolibrary.org/obo/HP_0001741	Phimosis	http://purl.obolibrary.org/obo/HP_0100587	Abnormal preputium morphology		The male foreskin cannot be fully retracted from the head of the penis.
http://purl.obolibrary.org/obo/HP_0001742	Nasal congestion	http://purl.obolibrary.org/obo/HP_0000366	Abnormality of the nose		Reduced ability to pass air through the nasal cavity often leading to mouth breathing.
http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the spleen	http://purl.obolibrary.org/obo/HP_0100763	Abnormality of the lymphatic system		An abnormality of the spleen.
http://purl.obolibrary.org/obo/HP_0001746	Asplenia	http://purl.obolibrary.org/obo/HP_0010451	Aplasia/Hypoplasia of the spleen		Absence (aplasia) of the spleen.
http://purl.obolibrary.org/obo/HP_0001747	Accessory spleen	http://purl.obolibrary.org/obo/HP_0009799	Supernumerary spleens		An accessory spleen is a round, iso-echogenic, homogenic and smooth structure and is seen as a normal variant mostly on the medial contour of the spleen, near the hilus or around the lower pole. This has no pathogenic relevance.
http://purl.obolibrary.org/obo/HP_0001748	Polysplenia	http://purl.obolibrary.org/obo/HP_0009799	Supernumerary spleens		Polysplenia is a congenital disease manifested by multiple small accessory spleens.
http://purl.obolibrary.org/obo/HP_0001750	Single ventricle	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		The presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle.
http://purl.obolibrary.org/obo/HP_0001751	Abnormal vestibular function	http://purl.obolibrary.org/obo/HP_0011389	Functional abnormality of the inner ear		An abnormality of the functioning of the vestibular apparatus.
http://purl.obolibrary.org/obo/HP_0001756	Vestibular hyporeflexia	http://purl.obolibrary.org/obo/HP_0001751	Abnormal vestibular function		A general descriptive term that describes impaired functioning of the vestibular apparatus that leads to manifestations such as dizziness or postural imbalance
http://purl.obolibrary.org/obo/HP_0001757	High-frequency sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		A form of sensorineural hearing impairment that affects primarily the higher frequencies.
http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		An abnormality of the skeleton of foot.
http://purl.obolibrary.org/obo/HP_0001761	Pes cavus	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		An increase in height of the medial longitudinal arch of the foot that does not flatten on weight bearing (i.e., a distinctly hollow form of the sole of the foot when it is bearing weight).
http://purl.obolibrary.org/obo/HP_0001763	Pes planus	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		A foot where the longitudinal arch of the foot is in contact with the ground or floor when the individual is standing; or, in a patient lying supine, a foot where the arch is in contact with the surface of a flat board pressed against the sole of the foot by the examiner with a pressure similar to that expected from weight bearing; or, the height of the arch is reduced.
http://purl.obolibrary.org/obo/HP_0001765	Hammertoe	http://purl.obolibrary.org/obo/HP_0034398	Toe deformity		Hyperextension of the metatarsal-phalangeal joint with hyperflexion of the proximal interphalangeal (PIP) joint.
http://purl.obolibrary.org/obo/HP_0001769	Broad foot	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		A foot for which the measured width is above the 95th centile for age; or, a foot that appears disproportionately wide for its length.
http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly	http://purl.obolibrary.org/obo/HP_0001159	Syndactyly		Webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are referred to as "Symphalangism".
http://purl.obolibrary.org/obo/HP_0001771	Achilles tendon contracture	http://purl.obolibrary.org/obo/HP_0008366	Foot joint contracture		A contracture of the Achilles tendon.
http://purl.obolibrary.org/obo/HP_0001772	Talipes equinovalgus	http://purl.obolibrary.org/obo/HP_0001883	Talipes		A deformity of foot and ankle in which the foot is bent down and outwards.
http://purl.obolibrary.org/obo/HP_0001773	Short foot	http://purl.obolibrary.org/obo/HP_0006494	Aplasia/Hypoplasia involving bones of the feet		A measured foot length that is more than 2 SD below the mean for a newborn of 27 - 41 weeks gestation, or foot that is less than the 3rd centile for individuals from birth to 16 years of age (objective). Alternatively, a foot that appears disproportionately short (subjective).
http://purl.obolibrary.org/obo/HP_0001776	Bilateral talipes equinovarus	http://purl.obolibrary.org/obo/HP_0001762	Talipes equinovarus		Bilateral clubfoot deformity.
http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		An anomaly of a toe.
http://purl.obolibrary.org/obo/HP_0001782	Bulbous tips of toes	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		An abnormality of the morphology of the toes, such that the tips of the toes are prominent and bulbous.
http://purl.obolibrary.org/obo/HP_0001783	Broad metatarsal	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		Increased side-to-side width of a metatarsal bone.
http://purl.obolibrary.org/obo/HP_0001786	Narrow foot	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		A foot for which the measured width is below the 5th centile for age; or, a foot that appears disproportionately narrow for its length.
http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		An abnormality of the birth process.
http://purl.obolibrary.org/obo/HP_0001788	Premature rupture of membranes	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor.
http://purl.obolibrary.org/obo/HP_0001790	Nonimmune hydrops fetalis	http://purl.obolibrary.org/obo/HP_0001789	Hydrops fetalis		A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens .
http://purl.obolibrary.org/obo/HP_0001791	Fetal ascites	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Accumulation of fluid in the peritoneal cavity during the fetal period.
http://purl.obolibrary.org/obo/HP_0001792	Small nail	http://purl.obolibrary.org/obo/HP_0008386	Aplasia/Hypoplasia of the nails		A nail that is diminished in length and width, i.e., underdeveloped nail.
http://purl.obolibrary.org/obo/HP_0001795	Hyperconvex nail	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		When viewed on end (with the digit tip pointing toward the examiner's eye) the curve of the nail forms a tighter curve of convexity.
http://purl.obolibrary.org/obo/HP_0001798	Anonychia	http://purl.obolibrary.org/obo/HP_0008386	Aplasia/Hypoplasia of the nails		Aplasia of the nail.
http://purl.obolibrary.org/obo/HP_0001799	Short nail	http://purl.obolibrary.org/obo/HP_0008386	Aplasia/Hypoplasia of the nails		Decreased length of nail.
http://purl.obolibrary.org/obo/HP_0001800	Hypoplastic toenails	http://purl.obolibrary.org/obo/HP_0010624	Aplastic/hypoplastic toenail		Underdevelopment of the toenail.
http://purl.obolibrary.org/obo/HP_0001802	Absent toenail	http://purl.obolibrary.org/obo/HP_0010624	Aplastic/hypoplastic toenail		Congenital absence of the toenail.
http://purl.obolibrary.org/obo/HP_0001803	Nail pits	http://purl.obolibrary.org/obo/HP_0025757	Abnormal nail surface		Small (typically about 1 mm or less in size) depressions on the dorsal nail surface.
http://purl.obolibrary.org/obo/HP_0001804	Hypoplastic fingernail	http://purl.obolibrary.org/obo/HP_0001792	Small nail		Underdevelopment of a fingernail.
http://purl.obolibrary.org/obo/HP_0001805	Onychogryphosis	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Onychogryphosis is a disorder of nail plate growth that is clinically characterized by an opaque, yellow-brown thickening of the nail plate with associated gross hyperkeratosis, elongation, and increased curvature.
http://purl.obolibrary.org/obo/HP_0001806	Onycholysis	http://purl.obolibrary.org/obo/HP_0025756	Abnormal nail attachment		Detachment of the nail from the nail bed.
http://purl.obolibrary.org/obo/HP_0001807	Ridged nail	http://purl.obolibrary.org/obo/HP_0025757	Abnormal nail surface		Longitudinal, linear prominences in the nail plate.
http://purl.obolibrary.org/obo/HP_0001808	Fragile nails	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Nails that easily break.
http://purl.obolibrary.org/obo/HP_0001809	Split nail	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		A nail plate that has a longitudinal separation and the two sections of the nail share the same lateral radius of curvature.
http://purl.obolibrary.org/obo/HP_0001810	Dystrophic toenail	http://purl.obolibrary.org/obo/HP_0008404	Nail dystrophy		Toenail changes apart from changes of the color of the toenail (nail dyschromia) that involve partial or complete disruption of the various keratinous layers of the nail plate.
http://purl.obolibrary.org/obo/HP_0001812	Hyperconvex fingernails	http://purl.obolibrary.org/obo/HP_0001795	Hyperconvex nail		When viewed on end (with the finger tip pointing toward the examiner's eye) the curve of the fingernail forms a tighter curve of convexity.
http://purl.obolibrary.org/obo/HP_0001814	Deep-set nails	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		Deeply placed nails.
http://purl.obolibrary.org/obo/HP_0001816	Thin nail	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Nail that appears thin when viewed on end.
http://purl.obolibrary.org/obo/HP_0001817	Absent fingernail	http://purl.obolibrary.org/obo/HP_0001798	Anonychia		Absence of a fingernail.
http://purl.obolibrary.org/obo/HP_0001818	Paronychia	http://purl.obolibrary.org/obo/HP_0100803	Abnormal periungual morphology		The nail disease paronychia is an often-tender bacterial or fungal hand infection or foot infection where the nail and skin meet at the side or the base of a finger or toenail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia).
http://purl.obolibrary.org/obo/HP_0001820	Leukonychia	http://purl.obolibrary.org/obo/HP_0100643	Abnormality of nail color		White discoloration of the nails.
http://purl.obolibrary.org/obo/HP_0001821	Broad nail	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		Increased width of nail.
http://purl.obolibrary.org/obo/HP_0001822	Hallux valgus	http://purl.obolibrary.org/obo/HP_0010051	Deviation of the hallux		Lateral deviation of the great toe (i.e., in the direction of the little toe).
http://purl.obolibrary.org/obo/HP_0001827	Genital tract atresia	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		Congenital occlusion of a tube in the genital tract.
http://purl.obolibrary.org/obo/HP_0001829	Foot polydactyly	http://purl.obolibrary.org/obo/HP_0010442	Polydactyly		A kind of polydactyly characterized by the presence of a supernumerary toe or toes.
http://purl.obolibrary.org/obo/HP_0001830	Postaxial foot polydactyly	http://purl.obolibrary.org/obo/HP_0100259	Postaxial polydactyly		Polydactyly of the foot most commonly refers to the presence of six toes on one foot. Postaxial polydactyly affects the lateral ray and the duplication may range from a well-formed articulated digit to a rudimentary digit.
http://purl.obolibrary.org/obo/HP_0001831	Short toe	http://purl.obolibrary.org/obo/HP_0011927	Short digit		A toe that appears disproportionately short compared to the foot.
http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		Abnormalities of the metatarsal bones (i.e. of five tubular bones located between the tarsal bones of the hind- and mid-foot and the phalanges of the toes).
http://purl.obolibrary.org/obo/HP_0001833	Long foot	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		Increased back to front length of the foot.
http://purl.obolibrary.org/obo/HP_0001836	Camptodactyly of toe	http://purl.obolibrary.org/obo/HP_0005830	Flexion contracture of toe		Camptodactyly is a painless flexion contracture of the proximal interphalangeal (PIP) joint that is usually gradually progressive. This term refers to camptodactyly of one or more toes.
http://purl.obolibrary.org/obo/HP_0001837	Broad toe	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Visible increase in width of the non-hallux digit without an increase in the dorso-ventral dimension.
http://purl.obolibrary.org/obo/HP_0001838	Rocker bottom foot	http://purl.obolibrary.org/obo/HP_5210430	Hindfoot deformity		The presence of both a prominent heel and a convex contour of the sole.
http://purl.obolibrary.org/obo/HP_0001839	Split foot	http://purl.obolibrary.org/obo/HP_0100257	Ectrodactyly		A condition in which middle parts of the foot (toes and metatarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe over absent 2nd or 3rd toes as far as oligo- or monodactyl feet.
http://purl.obolibrary.org/obo/HP_0001840	Metatarsus adductus	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		The metatarsals are deviated medially (tibially), that is, the bones in the front half of the foot bend or turn in toward the body.
http://purl.obolibrary.org/obo/HP_0001841	Preaxial foot polydactyly	http://purl.obolibrary.org/obo/HP_0100258	Preaxial polydactyly		Duplication of all or part of the first ray.
http://purl.obolibrary.org/obo/HP_0001844	Abnormal hallux morphology	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		This term applies for all abnormalities of the big toe, also called hallux.
http://purl.obolibrary.org/obo/HP_0001845	Overlapping toe	http://purl.obolibrary.org/obo/HP_0034398	Toe deformity		Describes a foot digit resting on the dorsal surface of an adjacent digit when the foot is at rest. Initially clawing may be dynamic and only noticeable on walking. Over time the plantar plate tears, subluxation occurs at the metatarsophalangeal joint (MTPJ), and the deformity becomes permanent.
http://purl.obolibrary.org/obo/HP_0001847	Long hallux	http://purl.obolibrary.org/obo/HP_0010511	Long toe		Increased length of the big toe.
http://purl.obolibrary.org/obo/HP_0001848	Calcaneovalgus deformity	http://purl.obolibrary.org/obo/HP_5210430	Hindfoot deformity		This is a postural deformity in which the foot is positioned up against the tibia. The heel (calcaneus) is positioned downward (that is, the ankle is flexed upward), and the heel is turned outward (valgus).
http://purl.obolibrary.org/obo/HP_0001849	Foot oligodactyly	http://purl.obolibrary.org/obo/HP_0012165	Oligodactyly		A developmental defect resulting in the presence of fewer than the normal number of toes.
http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		An abnormality of the tarsus are the cluster of seven bones in the foot between the tibia and fibula and the metatarsus, including the calcaneus (heel) bone and the talus (ankle) bone.
http://purl.obolibrary.org/obo/HP_0001852	Sandal gap	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		A widely spaced gap between the first toe (the great toe) and the second toe.
http://purl.obolibrary.org/obo/HP_0001854	Podagra	http://purl.obolibrary.org/obo/HP_0001997	Gout		Gout affecting the Metatarsophalangeal joint of big toe.
http://purl.obolibrary.org/obo/HP_0001857	Short distal phalanx of toe	http://purl.obolibrary.org/obo/HP_0005035	Shortening of all phalanges of the toes		Short distance from the end of the toe to the most distal interphalangeal crease or distal interphalangeal joint flexion point, i.e., abnormally short distal phalanx of toe.
http://purl.obolibrary.org/obo/HP_0001859	Distal toe symphalangism	http://purl.obolibrary.org/obo/HP_0100263	Distal symphalangism		Bony fusion at the distal interphalangeal joint of the second, third, fourth, or fifth toe.
http://purl.obolibrary.org/obo/HP_0001863	Toe clinodactyly	http://purl.obolibrary.org/obo/HP_0030084	Clinodactyly		Bending or curvature of a toe in the tibial direction (i.e., towards the big toe).
http://purl.obolibrary.org/obo/HP_0001864	Clinodactyly of the 5th toe	http://purl.obolibrary.org/obo/HP_0010344	Deviation of the 5th toe		Bending or curvature of a fifth toe in the tibial direction (i.e., towards the big toe).
http://purl.obolibrary.org/obo/HP_0001868	Autoamputation of foot	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		The spontaneous detachment of a foot from the body due to long standing pathology.
http://purl.obolibrary.org/obo/HP_0001869	Deep plantar creases	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot.
http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the hematopoietic system.
http://purl.obolibrary.org/obo/HP_0001872	Abnormality of thrombocytes	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		An abnormality of platelets.
http://purl.obolibrary.org/obo/HP_0001874	Abnormality of neutrophils	http://purl.obolibrary.org/obo/HP_0001911	Abnormal granulocyte morphology		A neutrophil abnormality.
http://purl.obolibrary.org/obo/HP_0001875	Decreased total neutrophil count	http://purl.obolibrary.org/obo/HP_0011991	Abnormal total neutrophil count		Abnormal decrease of absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		Any structural abnormality of erythrocytes (red-blood cells).
http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia	http://purl.obolibrary.org/obo/HP_0011895	Anemia due to reduced life span of red cells		A type of anemia caused by premature destruction of red blood cells (hemolysis).
http://purl.obolibrary.org/obo/HP_0001879	Abnormal eosinophil morphology	http://purl.obolibrary.org/obo/HP_0001911	Abnormal granulocyte morphology		An abnormal count or structure of eosinophils.
http://purl.obolibrary.org/obo/HP_0001881	Abnormal leukocyte morphology	http://purl.obolibrary.org/obo/HP_0010987	Abnormal cellular immune system morphology		An abnormality of leukocytes.
http://purl.obolibrary.org/obo/HP_0001883	Talipes	http://purl.obolibrary.org/obo/HP_0005656	Positional foot deformity		A deformity of foot and ankle that has different subtypes that are talipes equinovarus, talipes equinovalgus, talipes calcaneovarus and talipes calcaneovalgus.
http://purl.obolibrary.org/obo/HP_0001884	Talipes calcaneovalgus	http://purl.obolibrary.org/obo/HP_0001883	Talipes		Talipes calcaneovalgus is a flexible foot deformity (as opposed to a rigid congenital vertical talus foot deformity) that can either present as a positional or structural foot deformity depending on severity and/or causality. The axis of calcaneovalgus deformity is in the tibiotalar joint, where the foot is positioned in extreme hyperextension. On inspection, the foot has an "up and out" appearance, with the dorsal forefoot practically touching the anterior aspect of the ankle and lower leg.
http://purl.obolibrary.org/obo/HP_0001885	Short 2nd toe	http://purl.obolibrary.org/obo/HP_0001831	Short toe		Underdevelopment (hypoplasia) of the second toe.
http://purl.obolibrary.org/obo/HP_0001886	Foot osteomyelitis	http://purl.obolibrary.org/obo/HP_0002754	Osteomyelitis		An infection of bone of the foot.
http://purl.obolibrary.org/obo/HP_0001890	Autoimmune hemolytic anemia	http://purl.obolibrary.org/obo/HP_5210419	Autoimmune cytopenia		An autoimmune form of hemolytic anemia.
http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
http://purl.obolibrary.org/obo/HP_0001894	Thrombocytosis	http://purl.obolibrary.org/obo/HP_0011873	Abnormal platelet count		Increased numbers of platelets in the peripheral blood.
http://purl.obolibrary.org/obo/HP_0001896	Reticulocytopenia	http://purl.obolibrary.org/obo/HP_0004312	Abnormal reticulocyte morphology		A reduced number of reticulocytes in the peripheral blood.
http://purl.obolibrary.org/obo/HP_0001897	Normocytic anemia	http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production		A kind of anemia in which the volume of the red blood cells is normal.
http://purl.obolibrary.org/obo/HP_0001898	Increased red blood cell mass	http://purl.obolibrary.org/obo/HP_0001901	Polycythemia		The presence of an increased mass of red blood cells in the circulation.
http://purl.obolibrary.org/obo/HP_0001899	Increased hematocrit	http://purl.obolibrary.org/obo/HP_0031850	Abnormal hematocrit		An elevation above the normal ratio of the volume of red blood cells to the total volume of blood.
http://purl.obolibrary.org/obo/HP_0001900	Increased circulating hemoglobin concentration	http://purl.obolibrary.org/obo/HP_0020061	Abnormal hemoglobin concentration		Concentration of hemoglobin in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0001901	Polycythemia	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Polycythemia is diagnosed if the red blood cell count, the hemoglobin level, and the red blood cell volume all exceed the upper limits of normal.
http://purl.obolibrary.org/obo/HP_0001902	Giant platelets	http://purl.obolibrary.org/obo/HP_0011877	Increased mean platelet volume		Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. The term giant platelet is used when the platelet is larger than the size of the average red cell in the field. (Description adapted from College of American Pathologists, Hematology Manual, 1998).
http://purl.obolibrary.org/obo/HP_0001904	Autoimmune neutropenia	http://purl.obolibrary.org/obo/HP_5210419	Autoimmune cytopenia		Abnormal decrease of the absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group, accompanied by the detection of anti-neutrophil antibodies.
http://purl.obolibrary.org/obo/HP_0001905	Congenital thrombocytopenia	http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia		Thrombocytopenia with congenital onset.
http://purl.obolibrary.org/obo/HP_0001907	Thromboembolism	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site.
http://purl.obolibrary.org/obo/HP_0001908	Hypoplastic anemia	http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production		Anemia with varying degrees of erythrocytic hypoplasia without leukopenia or thrombocytopenia.
http://purl.obolibrary.org/obo/HP_0001909	Leukemia	http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm		A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.
http://purl.obolibrary.org/obo/HP_0001911	Abnormal granulocyte morphology	http://purl.obolibrary.org/obo/HP_0010974	Abnormal myeloid leukocyte morphology		Any structural abnormality or abnormal count of granulocytes.
http://purl.obolibrary.org/obo/HP_0001912	Abnormal basophil morphology	http://purl.obolibrary.org/obo/HP_0001911	Abnormal granulocyte morphology		Any structural abnormality or abnormal count of basophils.
http://purl.obolibrary.org/obo/HP_0001913	Decreased total granulocyte count	http://purl.obolibrary.org/obo/HP_0032309	Abnormal granulocyte count		Abnormal decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0001915	Aplastic anemia	http://purl.obolibrary.org/obo/HP_0001876	Pancytopenia		Aplastic anemia is defined as pancytopenia with a hypocellular marrow.
http://purl.obolibrary.org/obo/HP_0001917	Renal amyloidosis	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		A form of amyloidosis that affects the kidney. On hematoxylin and eosin stain, amyloid is identified as extracellular amorphous material that is lightly eosinophilic. These deposits often stain weakly for periodic acid Schiff (PAS), demonstrate a blue-to-gray hue on the trichrome stain and are typically negative on the Jones methenamine silver (JMS) stain. These tinctorial properties contrast with the histologic appearance of collagen, a major component of basement membranes, mesangial matrix and areas of sclerosis, which demonstrates strong positivity for PAS and JMS (See Figure 1 of PMID:25852856).
http://purl.obolibrary.org/obo/HP_0001919	Acute kidney injury	http://purl.obolibrary.org/obo/HP_0000083	Renal insufficiency		Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia).
http://purl.obolibrary.org/obo/HP_0001920	Renal artery stenosis	http://purl.obolibrary.org/obo/HP_0100545	Arterial stenosis		The presence of stenosis of the renal artery.
http://purl.obolibrary.org/obo/HP_0001922	Vacuolated lymphocytes	http://purl.obolibrary.org/obo/HP_0004332	Abnormal lymphocyte morphology		The presence of clear, sharply defined vacuoles in the lymphocyte cytoplasm.
http://purl.obolibrary.org/obo/HP_0001923	Reticulocytosis	http://purl.obolibrary.org/obo/HP_0004312	Abnormal reticulocyte morphology		An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation.
http://purl.obolibrary.org/obo/HP_0001927	Acanthocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		Acanthocytosis is a type of poikilocytosis characterized by the presence of spikes on the cell surface. The cells have an irregular shape resembling many-pointed stars.
http://purl.obolibrary.org/obo/HP_0001928	Abnormality of coagulation	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot.
http://purl.obolibrary.org/obo/HP_0001929	Reduced factor XI activity	http://purl.obolibrary.org/obo/HP_0010989	Abnormality of the intrinsic pathway		Decreased activity of coagulation factor XI. Factor XI, also known as plasma thromboplastin antecedent, is a serine proteinase that activates factor IX.
http://purl.obolibrary.org/obo/HP_0001931	Hypochromic anemia	http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production		A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes.
http://purl.obolibrary.org/obo/HP_0001933	Subcutaneous hemorrhage	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses).
http://purl.obolibrary.org/obo/HP_0001935	Microcytic anemia	http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production		A kind of anemia in which the volume of the red blood cells is reduced.
http://purl.obolibrary.org/obo/HP_0001941	Acidosis	http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis		Abnormal acid accumulation or depletion of base.
http://purl.obolibrary.org/obo/HP_0001942	Metabolic acidosis	http://purl.obolibrary.org/obo/HP_0001941	Acidosis		Metabolic acidosis (MA) is characterized by a fall in blood pH due to a reduction of serum bicarbonate concentration. This can occur as a result of either the accumulation of acids (high anion gap MA) or the loss of bicarbonate from the gastrointestinal tract or the kidney (hyperchloremic MA). By definition, MA is not due to a respirary cause.
http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia	http://purl.obolibrary.org/obo/HP_0011015	Abnormal blood glucose concentration		A decreased concentration of glucose in the blood.
http://purl.obolibrary.org/obo/HP_0001945	Fever	http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation		Body temperature elevated above the normal range.
http://purl.obolibrary.org/obo/HP_0001946	Ketosis	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Presence of elevated levels of ketone bodies in the body.
http://purl.obolibrary.org/obo/HP_0001947	Renal tubular acidosis	http://purl.obolibrary.org/obo/HP_0001942	Metabolic acidosis		Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia, potentially leading to complications including hypokalemia, hypercalcinuria, nephrolithiasis and nephrocalcinosis.
http://purl.obolibrary.org/obo/HP_0001948	Alkalosis	http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis		Depletion of acid or accumulation base in the body fluids.
http://purl.obolibrary.org/obo/HP_0001950	Respiratory alkalosis	http://purl.obolibrary.org/obo/HP_0001948	Alkalosis		Alkalosis due to excess loss of carbon dioxide from the body.
http://purl.obolibrary.org/obo/HP_0001952	Glucose intolerance	http://purl.obolibrary.org/obo/HP_0011014	Abnormal glucose homeostasis		Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM).
http://purl.obolibrary.org/obo/HP_0001953	Diabetic ketoacidosis	http://purl.obolibrary.org/obo/HP_0000819	Diabetes mellitus		A type of diabetic metabolic abnormality with an accumulation of ketone bodies.
http://purl.obolibrary.org/obo/HP_0001954	Recurrent fever	http://purl.obolibrary.org/obo/HP_0001945	Fever		Periodic (episodic or recurrent) bouts of fever.
http://purl.obolibrary.org/obo/HP_0001955	Unexplained fevers	http://purl.obolibrary.org/obo/HP_0001945	Fever		Episodes of fever for which no infectious cause can be identified.
http://purl.obolibrary.org/obo/HP_0001956	Truncal obesity	http://purl.obolibrary.org/obo/HP_0001513	Obesity		Obesity located preferentially in the trunk of the body as opposed to the extremities.
http://purl.obolibrary.org/obo/HP_0001959	Polydipsia	http://purl.obolibrary.org/obo/HP_0030082	Abnormal drinking behavior		Excessive thirst manifested by excessive fluid intake.
http://purl.obolibrary.org/obo/HP_0001961	Hypoplastic ventricle	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		A congenital defect characterized by underdevelopment of a ventricle of the heart.
http://purl.obolibrary.org/obo/HP_0001962	Palpitations	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.
http://purl.obolibrary.org/obo/HP_0001963	Abnormal speech discrimination	http://purl.obolibrary.org/obo/HP_0000364	Hearing abnormality		A type of hearing impairment prominently characterized by a difficulty in understanding speech, rather than an inability to hear speech. Poor speech discrimination is a very common symptom of high frequency hearing loss.
http://purl.obolibrary.org/obo/HP_0001964	Aplasia/Hypoplasia of metatarsal bones	http://purl.obolibrary.org/obo/HP_0006494	Aplasia/Hypoplasia involving bones of the feet		Absence or underdevelopment of the metatarsal bones.
http://purl.obolibrary.org/obo/HP_0001965	Abnormal scalp morphology	http://purl.obolibrary.org/obo/HP_0000234	Abnormality of the head		Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.
http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		An abnormality of the mesangium, i.e., of the central part of the renal glomerulus between capillaries.
http://purl.obolibrary.org/obo/HP_0001967	Diffuse mesangial sclerosis	http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology		Thickening and scarring (sclerosis) of the mesangium (a structure in the glomerulus). The sclerosis affects a large portion of the mesangium across multiple glomeruli. Histologic features include an increase in the mesangial matrix, thickened glomerular basement membrane, tubular casts, and interstitial inflammation. Diffuse mesangial sclerosis presents with nephrotic syndrome at birth or within the first year of life. Glomeruli are small and condensed in appearance, with early lesions showing increased loose mesangial collagen that progress to sclerosis with dense collagen without hypercellularity. Podocytes do not show hyperplasia but may be immature and cobblestone-like. Electron microscopy shows extensive foot process effacement without deposits, but increased collagen within mesangial areas.
http://purl.obolibrary.org/obo/HP_0001969	Abnormal tubulointerstitial morphology	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		An abnormality that involves the tubules and interstitial tissue of the kidney.
http://purl.obolibrary.org/obo/HP_0001970	Tubulointerstitial nephritis	http://purl.obolibrary.org/obo/HP_0001969	Abnormal tubulointerstitial morphology		A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.
http://purl.obolibrary.org/obo/HP_0001971	Hypersplenism	http://purl.obolibrary.org/obo/HP_0025409	Abnormal spleen physiology		A malfunctioning of the spleen in which it prematurely destroys red blood cells.
http://purl.obolibrary.org/obo/HP_0001972	Macrocytic anemia	http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production		A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).
http://purl.obolibrary.org/obo/HP_0001973	Autoimmune thrombocytopenia	http://purl.obolibrary.org/obo/HP_5210419	Autoimmune cytopenia		The presence of thrombocytopenia in combination with detection of antiplatelet antibodies.
http://purl.obolibrary.org/obo/HP_0001975	Decreased platelet glycoprotein IIb-IIIa	http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression		Decreased cell membrane concentration of glycoprotein IIb-IIIa.
http://purl.obolibrary.org/obo/HP_0001976	Reduced antithrombin III activity	http://purl.obolibrary.org/obo/HP_0010988	Abnormality of the extrinsic pathway		An abnormality of coagulation related to a decreased concentration of antithrombin-III.
http://purl.obolibrary.org/obo/HP_0001978	Extramedullary hematopoiesis	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms.
http://purl.obolibrary.org/obo/HP_0001980	Megaloblastic bone marrow	http://purl.obolibrary.org/obo/HP_0012145	Abnormality of multiple cell lineages in the bone marrow		Abnormal increased number of megaloblasts in the bone marrow.
http://purl.obolibrary.org/obo/HP_0001981	Schistocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood.
http://purl.obolibrary.org/obo/HP_0001982	Sea-blue histiocytosis	http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology		An abnormality of histiocytes, in which the cells take on a sea blue appearance due to abnormally increased lipid content. Histiocytes are a type of macrophage. Sea-blue histiocytes are typically large macrophages from 20 to 60 micrometers in diameter with a single eccentric nucleus whose cytoplasm if packed with sea-blue or blue-green granules when stained with Wright-Giemsa.
http://purl.obolibrary.org/obo/HP_0001983	Reduced lymphocyte surface expression of CD43	http://purl.obolibrary.org/obo/HP_0031383	Abnormal lymphocyte surface marker expression		A reduction in the expression of CD43 on the cell surface of lymphocytes.
http://purl.obolibrary.org/obo/HP_0001985	Hypoketotic hypoglycemia	http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia		A decreased concentration of glucose in the blood associated with a reduced concentration of ketone bodies.
http://purl.obolibrary.org/obo/HP_0001987	Hyperammonemia	http://purl.obolibrary.org/obo/HP_0002157	Azotemia		An increased concentration of ammonia in the blood.
http://purl.obolibrary.org/obo/HP_0001988	Recurrent hypoglycemia	http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia		Recurrent episodes of decreased concentration of glucose in the blood.
http://purl.obolibrary.org/obo/HP_0001989	Fetal akinesia sequence	http://purl.obolibrary.org/obo/HP_0001558	Decreased fetal movement		Decreased fetal activity associated with multiple joint contractures, facial anomalies and pulmonary hypoplasia. Ultrasound examination may reveal polyhydramnios, ankylosis, scalp edema, and decreased chest movements (reflecting pulmonary hypoplasia).
http://purl.obolibrary.org/obo/HP_0001991	Aplasia/Hypoplasia of toe	http://purl.obolibrary.org/obo/HP_0006494	Aplasia/Hypoplasia involving bones of the feet		Absence or hypoplasia of toes.
http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria	http://purl.obolibrary.org/obo/HP_0012072	Aciduria		Excretion of non-amino organic acids in urine.
http://purl.obolibrary.org/obo/HP_0001993	Ketoacidosis	http://purl.obolibrary.org/obo/HP_0001946	Ketosis		Acidosis resulting from accumulation of ketone bodies.
http://purl.obolibrary.org/obo/HP_0001994	Renal Fanconi syndrome	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		An inability of the tubules in the kidney to reabsorb small molecules, causing increased urinary loss of electrolytes (sodium, potassium, bicarbonate), minerals, glucose, amino acids, and water.
http://purl.obolibrary.org/obo/HP_0001995	Hyperchloremic acidosis	http://purl.obolibrary.org/obo/HP_0001941	Acidosis		Acidosis (pH less than 7.35) that develops with an increase in ionic chloride.
http://purl.obolibrary.org/obo/HP_0001996	Chronic metabolic acidosis	http://purl.obolibrary.org/obo/HP_0012468	Chronic acidosis		Longstanding metabolic acidosis.
http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		An abnormal morphology (form) of the face or its components.
http://purl.obolibrary.org/obo/HP_0002000	Short columella	http://purl.obolibrary.org/obo/HP_0009929	Abnormal columella morphology		Reduced distance from the anterior border of the naris to the subnasale.
http://purl.obolibrary.org/obo/HP_0002002	Deep philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Accentuated, prominent philtral ridges giving rise to an exaggerated groove in the midline between the nasal base and upper vermillion border.
http://purl.obolibrary.org/obo/HP_0002006	Tessier cleft	http://purl.obolibrary.org/obo/HP_5201015	Craniofacial cleft		A congenital malformation with a cleft (gap or opening) in the face.
http://purl.obolibrary.org/obo/HP_0002007	Frontal bossing	http://purl.obolibrary.org/obo/HP_0011218	Abnormal shape of the frontal region		Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.
http://purl.obolibrary.org/obo/HP_0002009	Potter facies	http://purl.obolibrary.org/obo/HP_0011334	Facial shape deformation		A facial appearance characteristic of a fetus or neonate due to oligohydramnios experienced in the womb, comprising ocular hypertelorism, low-set ears, receding chin, and flattening of the nose.
http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality	http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology		A structural abnormality of the central nervous system.
http://purl.obolibrary.org/obo/HP_0002012	Abnormality of the abdominal organs	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		An abnormality of the viscera of the abdomen.
http://purl.obolibrary.org/obo/HP_0002013	Vomiting	http://purl.obolibrary.org/obo/HP_0002017	Nausea and vomiting		Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
http://purl.obolibrary.org/obo/HP_0002014	Diarrhea	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.
http://purl.obolibrary.org/obo/HP_0002017	Nausea and vomiting	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea.
http://purl.obolibrary.org/obo/HP_0002018	Nausea	http://purl.obolibrary.org/obo/HP_0002017	Nausea and vomiting		A sensation of unease in the stomach together with an urge to vomit.
http://purl.obolibrary.org/obo/HP_0002019	Constipation	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Infrequent or difficult evacuation of feces.
http://purl.obolibrary.org/obo/HP_0002020	Gastroesophageal reflux	http://purl.obolibrary.org/obo/HP_0025270	Abnormal esophagus physiology		A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter.
http://purl.obolibrary.org/obo/HP_0002021	Pyloric stenosis	http://purl.obolibrary.org/obo/HP_0004400	Abnormality of the pylorus		Pyloric stenosis, also known as infantile hypertrophic pyloric stenosis, is an uncommon condition in infants characterized by abnormal thickening of the pylorus muscles in the stomach leading to gastric outlet obstruction. Clinically infants are well at birth. Then, at 3 to 6 weeks of age, the infants present with projectile vomiting, potentially leading to dehydration and weight loss.
http://purl.obolibrary.org/obo/HP_0002023	Anal atresia	http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology		Congenital absence of the anus, i.e., the opening at the bottom end of the intestinal tract.
http://purl.obolibrary.org/obo/HP_0002024	Malabsorption	http://purl.obolibrary.org/obo/HP_0025032	Abnormality of digestive system physiology		Impaired ability to absorb one or more nutrients from the intestine.
http://purl.obolibrary.org/obo/HP_0002025	Anal stenosis	http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology		Abnormal narrowing of the anal opening.
http://purl.obolibrary.org/obo/HP_0002027	Abdominal pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
http://purl.obolibrary.org/obo/HP_0002028	Chronic diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks.
http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		A structural abnormality of the esophagus.
http://purl.obolibrary.org/obo/HP_0002032	Esophageal atresia	http://purl.obolibrary.org/obo/HP_0002589	Gastrointestinal atresia		A developmental defect resulting in complete obliteration of the lumen of the esophagus such that the esophagus ends in a blind pouch rather than connecting to the stomach.
http://purl.obolibrary.org/obo/HP_0002033	Poor suck	http://purl.obolibrary.org/obo/HP_0008872	Feeding difficulties in infancy		An inadequate sucking reflex, resulting in the difficult of newborns to be breast-fed.
http://purl.obolibrary.org/obo/HP_0002034	Abnormal rectum morphology	http://purl.obolibrary.org/obo/HP_0012732	Anorectal anomaly		An abnormaltiy of the rectum, the final segment of the large intestine that stores solid waste until it passes through the anus.
http://purl.obolibrary.org/obo/HP_0002036	Hiatus hernia	http://purl.obolibrary.org/obo/HP_0100790	Hernia		The presence of a hernia in which the upper part of the stomach, i.e., mainly the gastric cardia protrudes through the diaphragmatic esophageal hiatus.
http://purl.obolibrary.org/obo/HP_0002037	Inflammation of the large intestine	http://purl.obolibrary.org/obo/HP_0004386	Gastrointestinal inflammation		Inflammation, or an inflammatory state in the large intestine.
http://purl.obolibrary.org/obo/HP_0002039	Anorexia	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Lack of desire to eat (loss of appetite).
http://purl.obolibrary.org/obo/HP_0002040	Esophageal varix	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Extreme dilation of the submucusoal veins in the lower portion of the esophagus.
http://purl.obolibrary.org/obo/HP_0002043	Esophageal stricture	http://purl.obolibrary.org/obo/HP_0010450	Esophageal stenosis		A pathological narrowing of the esophagus that is caused by the development of a ring of scar tissue that constricts the esophageal lumen.
http://purl.obolibrary.org/obo/HP_0002044	Zollinger-Ellison syndrome	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration.
http://purl.obolibrary.org/obo/HP_0002045	Hypothermia	http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation		Reduced body temperature due to failed thermoregulation.
http://purl.obolibrary.org/obo/HP_0002046	Heat intolerance	http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation		The inability to maintain a comfortable body temperature in warm or hot weather.
http://purl.obolibrary.org/obo/HP_0002047	Malignant hyperthermia	http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation		Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C. Malignant hyperthermia may occur in response to either inhalational anesthetics such as halothane, to muscle relaxants such as succinylcholine, or to exercise.
http://purl.obolibrary.org/obo/HP_0002048	Renal cortical atrophy	http://purl.obolibrary.org/obo/HP_0012585	Renal atrophy		Atrophy of the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0002049	Proximal renal tubular acidosis	http://purl.obolibrary.org/obo/HP_0001947	Renal tubular acidosis		A type of renal tubular acidosis characterized by a failure of the proximal tubular cells to reabsorb bicarbonate, leading to urinary bicarbonate wasting and subsequent acidemia.
http://purl.obolibrary.org/obo/HP_0002056	Abnormality of the glabella	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		An abnormality of the glabella.
http://purl.obolibrary.org/obo/HP_0002057	Prominent glabella	http://purl.obolibrary.org/obo/HP_0002056	Abnormality of the glabella		Forward protrusion of the glabella.
http://purl.obolibrary.org/obo/HP_0002058	Myopathic facies	http://purl.obolibrary.org/obo/HP_0004673	Decreased facial expression		A facial appearance characteristic of myopathic conditions. The face appears expressionless with sunken cheeks, bilateral ptosis, and inability to elevate the corners of the mouth, due to muscle weakness.
http://purl.obolibrary.org/obo/HP_0002059	Cerebral atrophy	http://purl.obolibrary.org/obo/HP_0007369	Atrophy/Degeneration affecting the cerebrum		Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum.
http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology	http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology		Any structural abnormality of the telencephalon, which is also known as the cerebrum.
http://purl.obolibrary.org/obo/HP_0002061	Lower limb spasticity	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the lower limbs, hips, and pelvis.
http://purl.obolibrary.org/obo/HP_0002062	Abnormal pyramidal tract morphology	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts.
http://purl.obolibrary.org/obo/HP_0002064	Spastic gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg.
http://purl.obolibrary.org/obo/HP_0002067	Bradykinesia	http://purl.obolibrary.org/obo/HP_0002071	Abnormality of extrapyramidal motor function		Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement).
http://purl.obolibrary.org/obo/HP_0002070	Limb ataxia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		A kind of ataxia that affects movements of the extremities.
http://purl.obolibrary.org/obo/HP_0002071	Abnormality of extrapyramidal motor function	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless).
http://purl.obolibrary.org/obo/HP_0002072	Chorea	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		Chorea (Greek for 'dance') refers to widespread arrhythmic involuntary movements of a forcible, jerky and restless fashion. It is a random-appearing sequence of one or more discrete involuntary movements or movement fragments. Movements appear random because of variability in timing, duration or location. Each movement may have a distinct start and end. However, movements may be strung together and thus may appear to flow randomly from one muscle group to another. Chorea can involve the trunk, neck, face, tongue, and extremities.
http://purl.obolibrary.org/obo/HP_0002074	Increased neuronal autofluorescent lipopigment	http://purl.obolibrary.org/obo/HP_0011813	Increased cerebral lipofuscin		Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the neuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient.
http://purl.obolibrary.org/obo/HP_0002075	Dysdiadochokinesis	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		A type of ataxia characterized by the impairment of the ability to perform rapidly alternating movements, such as pronating and supinating his or her hand on the dorsum of the other hand as rapidly as possible.
http://purl.obolibrary.org/obo/HP_0002076	Migraine	http://purl.obolibrary.org/obo/HP_0002315	Headache		Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
http://purl.obolibrary.org/obo/HP_0002077	Migraine with aura	http://purl.obolibrary.org/obo/HP_0002076	Migraine		A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.
http://purl.obolibrary.org/obo/HP_0002078	Truncal ataxia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		Truncal ataxia is a sign of ataxia characterized by instability of the trunk. It usually occurs during sitting.
http://purl.obolibrary.org/obo/HP_0002079	Hypoplasia of the corpus callosum	http://purl.obolibrary.org/obo/HP_0007370	Aplasia/Hypoplasia of the corpus callosum		Underdevelopment of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0002080	Intention tremor	http://purl.obolibrary.org/obo/HP_0030186	Kinetic tremor		A type of kinetic tremor that occurs during target directed movement is called intention tremor. That is, an oscillatory cerebellar ataxia that tends to be absent when the limbs are inactive and during the first part of voluntary movement but worsening as the movement continues and greater precision is required (e.g., in touching a target such as the patient's nose or a physician's finger).
http://purl.obolibrary.org/obo/HP_0002083	Migraine without aura	http://purl.obolibrary.org/obo/HP_0002076	Migraine		Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia.
http://purl.obolibrary.org/obo/HP_0002084	Encephalocele	http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect		A neural tube defect characterized by sac-like protrusions of the brain and the membranes that cover it through openings in the skull.
http://purl.obolibrary.org/obo/HP_0002085	Occipital encephalocele	http://purl.obolibrary.org/obo/HP_0002084	Encephalocele		A type of encephalocele (that is, a a protrusion of part of the cranial contents including brain tissue through a congenital opening in the cranium, typically covered with skin or mucous membrane) in the occipital region of the skull. Occipital encephalocele presents as a midline swelling over the occipital bone. It is usually covered with normal full-thickness scalp.
http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the respiratory system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.
http://purl.obolibrary.org/obo/HP_0002087	Abnormality of the upper respiratory tract	http://purl.obolibrary.org/obo/HP_0012252	Abnormal respiratory system morphology		An abnormality of the upper respiratory tract.
http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology	http://purl.obolibrary.org/obo/HP_0012252	Abnormal respiratory system morphology		Any structural anomaly of the lung.
http://purl.obolibrary.org/obo/HP_0002091	Restrictive ventilatory defect	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus.
http://purl.obolibrary.org/obo/HP_0002092	Pulmonary arterial hypertension	http://purl.obolibrary.org/obo/HP_0033578	Pre-capillary pulmonary hypertension		Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position.
http://purl.obolibrary.org/obo/HP_0002100	Recurrent aspiration pneumonia	http://purl.obolibrary.org/obo/HP_0011951	Aspiration pneumonia		Increased susceptibility to aspiration pneumonia, defined as pneumonia due to breathing in foreign material, as manifested by a medical history of repeated episodes of aspiration pneumonia.
http://purl.obolibrary.org/obo/HP_0002101	Abnormal lung lobation	http://purl.obolibrary.org/obo/HP_4000059	Abnormal lung development		A developmental defect in the formation of pulmonary lobes.
http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls.
http://purl.obolibrary.org/obo/HP_0002104	Apnea	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Lack of breathing with no movement of the respiratory muscles and no exchange of air in the lungs. This term refers to a disposition to have recurrent episodes of apnea rather than to a single event.
http://purl.obolibrary.org/obo/HP_0002107	Pneumothorax	http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology		Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung.
http://purl.obolibrary.org/obo/HP_0002108	Spontaneous pneumothorax	http://purl.obolibrary.org/obo/HP_0002107	Pneumothorax		Pneumothorax occurring without traumatic injury to the chest or lung.
http://purl.obolibrary.org/obo/HP_0002110	Bronchiectasis	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.
http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		Any structural abnormality of the cerebral ventricles.
http://purl.obolibrary.org/obo/HP_0002119	Ventriculomegaly	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		An increase in size of the ventricular system of the brain.
http://purl.obolibrary.org/obo/HP_0002120	Cerebral cortical atrophy	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		Atrophy of the cortex of the cerebrum.
http://purl.obolibrary.org/obo/HP_0002121	Generalized non-motor (absence) seizure	http://purl.obolibrary.org/obo/HP_0033259	Non-motor seizure		A generalized non-motor (absence) seizure is a type of a type of dialeptic seizure that is of electrographically generalized onset. It is a generalized seizure characterized by an interruption of activities, a blank stare, and usually the person will be unresponsive when spoken to. Any ictal motor phenomena are minor in comparison to these non-motor features.
http://purl.obolibrary.org/obo/HP_0002123	Generalized myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032794	Myoclonic seizure		A generalized myoclonic seizure is a type of generalized motor seizure characterized by bilateral, sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.
http://purl.obolibrary.org/obo/HP_0002126	Polymicrogyria	http://purl.obolibrary.org/obo/HP_0002536	Abnormal cortical gyration		Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds).
http://purl.obolibrary.org/obo/HP_0002127	Abnormal upper motor neuron morphology	http://purl.obolibrary.org/obo/HP_0002450	Abnormal motor neuron morphology		Any structural anomaly that affects the upper motor neuron.
http://purl.obolibrary.org/obo/HP_0002131	Episodic ataxia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		Periodic spells of incoordination and imbalance, that is, episodes of ataxia typically lasting from 10 minutes to several hours or days.
http://purl.obolibrary.org/obo/HP_0002132	Porencephalic cyst	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		A cavity within the cerebral hemisphere, filled with cerebrospinal fluid, that communicates directly with the ventricular system.
http://purl.obolibrary.org/obo/HP_0002133	Status epilepticus	http://purl.obolibrary.org/obo/HP_0001250	Seizure		Status epilepticus is a type of prolonged seizure resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms which lead to abnormally prolonged seizures (after time point t1). It is a condition that can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures.
http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology	http://purl.obolibrary.org/obo/HP_0010993	Abnormal cerebral subcortex morphology		Abnormality of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0002135	Basal ganglia calcification	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		The presence of calcium deposition affecting one or more structures of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0002136	Broad-based gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		An abnormal gait pattern in which persons stand and walk with their feet spaced widely apart. This is often a component of cerebellar ataxia.
http://purl.obolibrary.org/obo/HP_0002138	Subarachnoid hemorrhage	http://purl.obolibrary.org/obo/HP_0012703	Abnormal subarachnoid space morphology		Hemorrhage occurring between the arachnoid mater and the pia mater.
http://purl.obolibrary.org/obo/HP_0002139	Arrhinencephaly	http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology		A defect of development of the brain characterized by congenital absence of the part of the brain that includes the olfactory bulbs, tracts, and other structures associated with the sense of smell.
http://purl.obolibrary.org/obo/HP_0002140	Ischemic stroke	http://purl.obolibrary.org/obo/HP_0025722	Cerebral infarct		Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured.
http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		A structural abnormality of the spinal cord (myelon).
http://purl.obolibrary.org/obo/HP_0002144	Tethered cord	http://purl.obolibrary.org/obo/HP_0031938	Abnormal conus terminalis morphology		During normal embryological development, the spinal cord first occupies the entire length of the vertebral column but goes on to assume a position at the level of L1 due to differential growth of the conus medullaris and the vertebral column. The filum terminale is a slender, threadlike structure that remains after the normal regression of the distal embryonic spinal cord and attaches the spinal cord to the coccyx. A tethered cord results if there is a thickened rope-like filum terminale which anchors the cord at the level of L2 or below, potentially causing neurologic signs owing to abnormal tension on the spinal cord.
http://purl.obolibrary.org/obo/HP_0002145	Frontotemporal dementia	http://purl.obolibrary.org/obo/HP_0000726	Dementia		A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders.
http://purl.obolibrary.org/obo/HP_0002148	Hypophosphatemia	http://purl.obolibrary.org/obo/HP_0100529	Abnormal circulating phosphate ion concentration		The concentration of phosphate ion in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0002151	Increased circulating lactate concentration	http://purl.obolibrary.org/obo/HP_0001941	Acidosis		Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35).
http://purl.obolibrary.org/obo/HP_0002152	Hyperproteinemia	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		An increased concentration of proteins in the blood.
http://purl.obolibrary.org/obo/HP_0002153	Hyperkalemia	http://purl.obolibrary.org/obo/HP_0011042	Abnormal circulating potassium concentration		The concentration of potassium(1+) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0002154	Hyperglycinemia	http://purl.obolibrary.org/obo/HP_0010895	Abnormal circulating glycine concentration		An elevated concentration of glycine in the blood.
http://purl.obolibrary.org/obo/HP_0002155	Hypertriglyceridemia	http://purl.obolibrary.org/obo/HP_0003077	Hyperlipidemia		An abnormal increase in the level of triglycerides in the blood.
http://purl.obolibrary.org/obo/HP_0002157	Azotemia	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		An increased concentration of nitrogen compounds in the blood.
http://purl.obolibrary.org/obo/HP_0002159	Heparan sulfate excretion in urine	http://purl.obolibrary.org/obo/HP_0008155	Mucopolysacchariduria		An increased concentration of heparan sulfates in the urine.
http://purl.obolibrary.org/obo/HP_0002160	Hyperhomocystinemia	http://purl.obolibrary.org/obo/HP_0010919	Abnormal circulating homocysteine concentration		An increased concentration of homocystine in the blood.
http://purl.obolibrary.org/obo/HP_0002161	Hyperlysinemia	http://purl.obolibrary.org/obo/HP_0010908	Abnormal circulating lysine concentration		The concentration of lysine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0002162	Low posterior hairline	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Hair on the neck extends more inferiorly than usual.
http://purl.obolibrary.org/obo/HP_0002165	Nail pterygium	http://purl.obolibrary.org/obo/HP_0025756	Abnormal nail attachment		Inward advance of skin over the nail plate.
http://purl.obolibrary.org/obo/HP_0002166	Impaired vibration sensation in the lower limbs	http://purl.obolibrary.org/obo/HP_0002495	Impaired vibratory sensation		A decrease in the ability to perceive vibration in the legs.
http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern	http://purl.obolibrary.org/obo/HP_4000072	Abnormal language feature		An abnormality in the sound (volume) or cadence (rate) of speech.
http://purl.obolibrary.org/obo/HP_0002168	Scanning speech	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		An abnormal pattern of speech in which the words are as if measured or scanned; there is a pause after every syllable, and the syllables themselves are pronounced slowly.
http://purl.obolibrary.org/obo/HP_0002169	Clonus	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch.
http://purl.obolibrary.org/obo/HP_0002170	Intracranial hemorrhage	http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage		Hemorrhage occurring within the skull.
http://purl.obolibrary.org/obo/HP_0002171	Gliosis	http://purl.obolibrary.org/obo/HP_0100705	Abnormal glial cell morphology		Gliosis is the focal proliferation of glial cells in the central nervous system.
http://purl.obolibrary.org/obo/HP_0002172	Postural instability	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps.
http://purl.obolibrary.org/obo/HP_0002174	Postural tremor	http://purl.obolibrary.org/obo/HP_0002345	Action tremor		A type of tremors that is triggered by holding a limb in a fixed position.
http://purl.obolibrary.org/obo/HP_0002176	Spinal cord compression	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		External mechanical compression of the spinal cord.
http://purl.obolibrary.org/obo/HP_0002179	Opisthotonus	http://purl.obolibrary.org/obo/HP_0001257	Spasticity		Opisthotonus is defined as a dramatic abnormal posture due to spastic contraction of the extensor muscles of the neck, trunk, and lower extremities that produces a severe backward arching from neck to heel. In most cases, the trunk is elevated off the ground by a few inches. It is usually sudden in onset and can be sustained or repetitive. It can be considered a variant of decerebrate posturing involving a hyperextension of the neck, back, and limbs.
http://purl.obolibrary.org/obo/HP_0002180	Neurodegeneration	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		Progressive loss of neural cells and tissue.
http://purl.obolibrary.org/obo/HP_0002181	Cerebral edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Abnormal accumulation of fluid in the brain.
http://purl.obolibrary.org/obo/HP_0002183	Phonophobia	http://purl.obolibrary.org/obo/HP_5200060	Auditory hypersensitivity		An abnormally heightened sensitivity to loud sounds.
http://purl.obolibrary.org/obo/HP_0002185	Neurofibrillary tangles	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form.
http://purl.obolibrary.org/obo/HP_0002186	Apraxia	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements.
http://purl.obolibrary.org/obo/HP_0002187	Profound intellectual disability	http://purl.obolibrary.org/obo/HP_0001249	Intellectual disability		Profound intellectual disability (ID) is defined as a type of ID characterized by profoundly sub-average adaptive functioning and intellectual functioning, with an intelligence quotient (IQ) below 20.
http://purl.obolibrary.org/obo/HP_0002188	Delayed CNS myelination	http://purl.obolibrary.org/obo/HP_0012448	Delayed myelination		Delayed myelination in the central nervous system.
http://purl.obolibrary.org/obo/HP_0002190	Choroid plexus cyst	http://purl.obolibrary.org/obo/HP_0007376	Abnormal choroid plexus morphology		A cyst occurring within the choroid plexus within a cerebral ventricle.
http://purl.obolibrary.org/obo/HP_0002191	Progressive spasticity	http://purl.obolibrary.org/obo/HP_0001257	Spasticity		Spasticity that increases in degree with time.
http://purl.obolibrary.org/obo/HP_0002193	Pseudobulbar affect	http://purl.obolibrary.org/obo/HP_0002200	Pseudobulbar signs		Pseudobulbar affect (PBA) is characterized by uncontrolled crying or laughing which may be disproportionate or inappropriate to the social context. Thus, there is a disparity between the patient's emotional expression and his or her emotional experience.
http://purl.obolibrary.org/obo/HP_0002194	Delayed gross motor development	http://purl.obolibrary.org/obo/HP_0001270	Motor delay		A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling.
http://purl.obolibrary.org/obo/HP_0002195	Dysgenesis of the cerebellar vermis	http://purl.obolibrary.org/obo/HP_0002334	Abnormal cerebellar vermis morphology		Defective development of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0002196	Myelopathy	http://purl.obolibrary.org/obo/HP_0034238	Closed neural tube defect		Myelopathy is an descriptive term, referring to pathology leading to a neurologic deficit related to the spinal cord. The clinical diagnosis of myelopathy requires a detailed history and physical examination to define the clinical syndrome. Neuroimaging is indicated in most instances of new-onset myelopathy. It is indicated also when the worsening of a myelopathy is unexplained.
http://purl.obolibrary.org/obo/HP_0002197	Generalized-onset seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A generalized-onset seizure is a type of seizure originating at some point within, and rapidly engaging, bilaterally distributed networks. The networks may include cortical and subcortical structures but not necessarily the entire cortex.
http://purl.obolibrary.org/obo/HP_0002198	Dilated fourth ventricle	http://purl.obolibrary.org/obo/HP_0010950	Abnormal fourth ventricle morphology		An abnormal dilatation of the fourth cerebral ventricle.
http://purl.obolibrary.org/obo/HP_0002200	Pseudobulbar signs	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc.
http://purl.obolibrary.org/obo/HP_0002203	Respiratory paralysis	http://purl.obolibrary.org/obo/HP_0003470	Paralysis		Inability to move the muscles of respiration.
http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections	http://purl.obolibrary.org/obo/HP_0011947	Respiratory tract infection		An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.
http://purl.obolibrary.org/obo/HP_0002206	Pulmonary fibrosis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Replacement of normal lung tissues by fibroblasts and collagen.
http://purl.obolibrary.org/obo/HP_0002208	Coarse hair	http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture		Hair shafts are rough in texture.
http://purl.obolibrary.org/obo/HP_0002209	Sparse scalp hair	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Decreased number of hairs per unit area of skin of the scalp.
http://purl.obolibrary.org/obo/HP_0002211	White forelock	http://purl.obolibrary.org/obo/HP_0011365	Patchy hypopigmentation of hair		A triangular depigmented region of white hairs located in the anterior midline of the scalp.
http://purl.obolibrary.org/obo/HP_0002213	Fine hair	http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture		Hair that is fine or thin to the touch.
http://purl.obolibrary.org/obo/HP_0002215	Sparse axillary hair	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Reduced number or density of axillary hair.
http://purl.obolibrary.org/obo/HP_0002216	Premature graying of hair	http://purl.obolibrary.org/obo/HP_0009887	Abnormality of hair pigmentation		Development of gray hair at a younger than normal age.
http://purl.obolibrary.org/obo/HP_0002217	Slow-growing hair	http://purl.obolibrary.org/obo/HP_0011363	Abnormality of hair growth rate		Hair whose growth is slower than normal.
http://purl.obolibrary.org/obo/HP_0002218	Silver-gray hair	http://purl.obolibrary.org/obo/HP_0011358	Generalized hypopigmentation of hair		Hypopigmented hair that appears silver-gray.
http://purl.obolibrary.org/obo/HP_0002219	Facial hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		Excessive, increased hair growth located in the facial region.
http://purl.obolibrary.org/obo/HP_0002221	Absent axillary hair	http://purl.obolibrary.org/obo/HP_0100134	Abnormality of the axillary hair		Absence of axillary hair.
http://purl.obolibrary.org/obo/HP_0002223	Absent eyebrow	http://purl.obolibrary.org/obo/HP_0100840	Aplasia/Hypoplasia of the eyebrow		Absence of the eyebrow.
http://purl.obolibrary.org/obo/HP_0002224	Woolly hair	http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture		The term wooly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter.
http://purl.obolibrary.org/obo/HP_0002225	Sparse pubic hair	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Reduced number or density of pubic hair.
http://purl.obolibrary.org/obo/HP_0002226	White eyebrow	http://purl.obolibrary.org/obo/HP_0009887	Abnormality of hair pigmentation		White color (lack of pigmentation) of the eyebrow.
http://purl.obolibrary.org/obo/HP_0002227	White eyelashes	http://purl.obolibrary.org/obo/HP_0009887	Abnormality of hair pigmentation		White color (lack of pigmentation) of the eyelashes.
http://purl.obolibrary.org/obo/HP_0002230	Generalized hirsutism	http://purl.obolibrary.org/obo/HP_0001007	Hirsutism		Abnormally increased hair growth over much of the entire body.
http://purl.obolibrary.org/obo/HP_0002231	Sparse body hair	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Sparseness of the body hair.
http://purl.obolibrary.org/obo/HP_0002232	Patchy alopecia	http://purl.obolibrary.org/obo/HP_0001596	Alopecia		Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.
http://purl.obolibrary.org/obo/HP_0002234	Early balding	http://purl.obolibrary.org/obo/HP_0011360	Acquired abnormal hair pattern		Loss of scalp hair at an earlier than normal age.
http://purl.obolibrary.org/obo/HP_0002235	Pili canaliculi	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		A characteristic triangular, kidney- or heat-shaped diameter of hair shafts with typical longitudinal canalicular deformation as observable by scanning electron microscopy.
http://purl.obolibrary.org/obo/HP_0002236	Frontal upsweep of hair	http://purl.obolibrary.org/obo/HP_0010721	Abnormal hair whorl		Upward and/or sideward growth of anterior hair.
http://purl.obolibrary.org/obo/HP_0002240	Hepatomegaly	http://purl.obolibrary.org/obo/HP_0003271	Visceromegaly		Abnormally increased size of the liver.
http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine.
http://purl.obolibrary.org/obo/HP_0002243	Protein-losing enteropathy	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		Abnormal loss of protein from the digestive tract related to excessive leakage of plasma proteins into the lumen of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		A structural abnormality of the small intestine.
http://purl.obolibrary.org/obo/HP_0002245	Meckel diverticulum	http://purl.obolibrary.org/obo/HP_0001549	Abnormal ileum morphology		Meckel's diverticulum is a congenital diverticulum located in the distal ileum.
http://purl.obolibrary.org/obo/HP_0002246	Abnormal duodenum morphology	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		An abnormality of the duodenum, i.e., the first section of the small intestine.
http://purl.obolibrary.org/obo/HP_0002247	Duodenal atresia	http://purl.obolibrary.org/obo/HP_0011100	Intestinal atresia		A developmental defect resulting in complete obliteration of the duodenal lumen, that is, an abnormal closure of the duodenum.
http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		Any abnormality of the large intestine.
http://purl.obolibrary.org/obo/HP_0002251	Aganglionic megacolon	http://purl.obolibrary.org/obo/HP_6000852	Megacolon		An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon.
http://purl.obolibrary.org/obo/HP_0002253	Colonic diverticula	http://purl.obolibrary.org/obo/HP_0005222	Bowel diverticulosis		The presence of multiple diverticula of the colon.
http://purl.obolibrary.org/obo/HP_0002254	Intermittent diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		Repeated episodes of diarrhea separated by periods without diarrhea.
http://purl.obolibrary.org/obo/HP_0002257	Chronic rhinitis	http://purl.obolibrary.org/obo/HP_0012384	Rhinitis		Chronic inflammation of the nasal mucosa.
http://purl.obolibrary.org/obo/HP_0002263	Exaggerated cupid's bow	http://purl.obolibrary.org/obo/HP_0011339	Abnormality of upper lip vermillion		More pronounced paramedian peaks and median notch of the Cupid's bow.
http://purl.obolibrary.org/obo/HP_0002266	Focal clonic seizure	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A focal clonic seizure is a type of focal motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.
http://purl.obolibrary.org/obo/HP_0002267	Exaggerated startle response	http://purl.obolibrary.org/obo/HP_0002071	Abnormality of extrapyramidal motor function		An exaggerated startle reaction in response to a sudden unexpected visual or acoustic stimulus, or a quick movement near the face.
http://purl.obolibrary.org/obo/HP_0002268	Paroxysmal dystonia	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		A form of dystonia characterized by episodes of dystonia (often hemidystonia or generalized) lasting from minutes to hours. There are no dystonic symptoms between episodes.
http://purl.obolibrary.org/obo/HP_0002269	Abnormality of neuronal migration	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		An abnormality resulting from an anomaly of neuronal migration, i.e., of the process by which neurons travel from their origin to their final position in the brain.
http://purl.obolibrary.org/obo/HP_0002270	Abnormality of the autonomic nervous system	http://purl.obolibrary.org/obo/HP_0410008	Abnormality of the peripheral nervous system		An abnormality of the autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0002273	Tetraparesis	http://purl.obolibrary.org/obo/HP_0030182	Tetraplegia/tetraparesis		Weakness of all four limbs.
http://purl.obolibrary.org/obo/HP_0002277	Horner syndrome	http://purl.obolibrary.org/obo/HP_0000508	Ptosis		An abnormality resulting from a lesion of the sympathetic nervous system characterized by a combination of unilateral ptosis, miosis, and often ipsilateral hypohidrosis and conjunctival injection.
http://purl.obolibrary.org/obo/HP_0002280	Enlarged cisterna magna	http://purl.obolibrary.org/obo/HP_0005445	Enlarged posterior fossa		Increase in size of the cisterna magna, one of three principal openings in the subarachnoid space between the arachnoid and pia mater, located between the cerebellum and the dorsal surface of the medulla oblongata.
http://purl.obolibrary.org/obo/HP_0002282	Gray matter heterotopia	http://purl.obolibrary.org/obo/HP_0002269	Abnormality of neuronal migration		Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter.
http://purl.obolibrary.org/obo/HP_0002283	Global brain atrophy	http://purl.obolibrary.org/obo/HP_0012444	Brain atrophy		Unlocalized atrophy of the brain with decreased total brain matter volume and increased ventricular size.
http://purl.obolibrary.org/obo/HP_0002286	Fair hair	http://purl.obolibrary.org/obo/HP_0011358	Generalized hypopigmentation of hair		A lesser degree of hair pigmentation than would otherwise be expected.
http://purl.obolibrary.org/obo/HP_0002287	Progressive alopecia	http://purl.obolibrary.org/obo/HP_0001596	Alopecia		Progressive loss of hair.
http://purl.obolibrary.org/obo/HP_0002289	Alopecia universalis	http://purl.obolibrary.org/obo/HP_0001596	Alopecia		Loss of all hair on the entire body.
http://purl.obolibrary.org/obo/HP_0002290	Poliosis	http://purl.obolibrary.org/obo/HP_0011365	Patchy hypopigmentation of hair		Circumscribed depigmentation of the hair of the head or the eyelashes.
http://purl.obolibrary.org/obo/HP_0002292	Frontal balding	http://purl.obolibrary.org/obo/HP_0011360	Acquired abnormal hair pattern		Absence of hair in the anterior midline and/or parietal areas.
http://purl.obolibrary.org/obo/HP_0002296	Progressive hypotrichosis	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Progressively reduced or lacking hair growth.
http://purl.obolibrary.org/obo/HP_0002299	Brittle hair	http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture		Fragile, easily breakable hair, i.e., with reduced tensile strength.
http://purl.obolibrary.org/obo/HP_0002300	Mutism	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		Complete lack of speech or verbal communication in a person despite attempts to engage in conversation. Mutism as a phenomena assumes the individual has previous capacity for speech and in the pediatric population it assumes that the person is past the age of typical language development.
http://purl.obolibrary.org/obo/HP_0002301	Hemiplegia	http://purl.obolibrary.org/obo/HP_0004374	Hemiplegia/hemiparesis		Paralysis (complete loss of muscle function) in the arm, leg, and in some cases the face on one side of the body.
http://purl.obolibrary.org/obo/HP_0002304	Akinesia	http://purl.obolibrary.org/obo/HP_0002374	Diminished movement		Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily.
http://purl.obolibrary.org/obo/HP_0002305	Athetosis	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest.
http://purl.obolibrary.org/obo/HP_0002307	Drooling	http://purl.obolibrary.org/obo/HP_0003781	Excessive salivation		Habitual flow of saliva out of the mouth.
http://purl.obolibrary.org/obo/HP_0002308	Chiari malformation	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		Chiari malformation consists of a downward displacement of the cerebellar tonsils and the medulla through the foramen magnum, sometimes causing hydrocephalus as a result of obstruction of CSF outflow.
http://purl.obolibrary.org/obo/HP_0002311	Incoordination	http://purl.obolibrary.org/obo/HP_0011443	Abnormality of coordination		A deficit in coordination of muscle movements. Coordination is defined as the orchestrated movement of multiple body parts as required to accomplish intended actions, like walking.
http://purl.obolibrary.org/obo/HP_0002312	Clumsiness	http://purl.obolibrary.org/obo/HP_0011443	Abnormality of coordination		Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects.
http://purl.obolibrary.org/obo/HP_0002313	Spastic paraparesis	http://purl.obolibrary.org/obo/HP_0002385	Paraparesis		Partial loss of the ability to move the lower limbs accompanied by spasticity of the lower limbs.
http://purl.obolibrary.org/obo/HP_0002314	Degeneration of the lateral corticospinal tracts	http://purl.obolibrary.org/obo/HP_0007372	Atrophy/Degeneration involving the corticospinal tracts		Deterioration of the tissues of the lateral corticospinal tracts.
http://purl.obolibrary.org/obo/HP_0002315	Headache	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
http://purl.obolibrary.org/obo/HP_0002318	Cervical myelopathy	http://purl.obolibrary.org/obo/HP_0002196	Myelopathy		A collection of pathologic conditions that result from progressive spinal cord dysfunction secondary to cord compression in the cervical spine.
http://purl.obolibrary.org/obo/HP_0002321	Vertigo	http://purl.obolibrary.org/obo/HP_0001751	Abnormal vestibular function		An abnormal sensation of spinning while the body is actually stationary.
http://purl.obolibrary.org/obo/HP_0002322	Resting tremor	http://purl.obolibrary.org/obo/HP_0001337	Tremor		A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.
http://purl.obolibrary.org/obo/HP_0002323	Anencephaly	http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect		Anencephaly is a developmental anomaly characterized by a fetus that has no calvarium, with a lack of most or all of the fetus' brain tissue. Anencephaly belongs to a collective group known as neural tube defects (NTD) and is a result of the neural tube failing to close in its rostral end during fetal development.
http://purl.obolibrary.org/obo/HP_0002324	Hydranencephaly	http://purl.obolibrary.org/obo/HP_0002323	Anencephaly		A defect of development of the brain characterized by replacement of greater portions of the cerebral hemispheres and the corpus striatum by cerebrospinal fluid (CSF) and glial tissue.
http://purl.obolibrary.org/obo/HP_0002330	Sleep attack	http://purl.obolibrary.org/obo/HP_0025288	Excessive sleep		A sleep attack is a sudden, irresistable episode of sleep that occurs during waking hours.
http://purl.obolibrary.org/obo/HP_0002331	Recurrent paroxysmal headache	http://purl.obolibrary.org/obo/HP_0002315	Headache		Repeated episodes of headache with rapid onset, reaching a peak within minutes and of short duration (less than one hour) with pain that is throbbing, pulsating, or bursting in quality.
http://purl.obolibrary.org/obo/HP_0002332	Lack of peer relationships	http://purl.obolibrary.org/obo/HP_5200016	Abnormal peer relationships		The state of not having relationships with peers outside of school or organized activity appropriate to developmental level. This may be caused by behavioral or physical barriers.
http://purl.obolibrary.org/obo/HP_0002333	Motor deterioration	http://purl.obolibrary.org/obo/HP_0001268	Mental deterioration		Loss of previously present motor (i.e., movement) abilities.
http://purl.obolibrary.org/obo/HP_0002334	Abnormal cerebellar vermis morphology	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		An anomaly of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0002335	Agenesis of cerebellar vermis	http://purl.obolibrary.org/obo/HP_0006817	Aplasia/Hypoplasia of the cerebellar vermis		Congenital absence of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0002339	Abnormal caudate nucleus morphology	http://purl.obolibrary.org/obo/HP_0010994	Abnormal corpus striatum morphology		Any structural abnormality of the caudate nucleus.
http://purl.obolibrary.org/obo/HP_0002341	Cervical cord compression	http://purl.obolibrary.org/obo/HP_0002176	Spinal cord compression		Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness.
http://purl.obolibrary.org/obo/HP_0002342	Moderate intellectual disability	http://purl.obolibrary.org/obo/HP_0001249	Intellectual disability		Moderate intellectual disability (ID) is defined as a type of ID characterized by moderately sub-average adaptive functioning and intellectual functioning, with an intelligence quotient (IQ) the range of 35-49.
http://purl.obolibrary.org/obo/HP_0002343	Normal pressure hydrocephalus	http://purl.obolibrary.org/obo/HP_0000238	Hydrocephalus		A form of hydrocephalus characterized by enlarged cerebral ventricles and normal cerebrospinal fluid (CSF) pressure upon lumbar puncture.
http://purl.obolibrary.org/obo/HP_0002345	Action tremor	http://purl.obolibrary.org/obo/HP_0001337	Tremor		A tremor present when the limbs are active, either when outstretched in a certain position or throughout a voluntary movement.
http://purl.obolibrary.org/obo/HP_0002346	Head tremor	http://purl.obolibrary.org/obo/HP_0030188	Tremor by anatomical site		An unintentional, oscillating to-and-fro muscle movement affecting head movement.
http://purl.obolibrary.org/obo/HP_0002349	Focal aware seizure	http://purl.obolibrary.org/obo/HP_0007359	Focal-onset seizure		A type of focal-onset seizure in which awareness is preserved. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile.
http://purl.obolibrary.org/obo/HP_0002352	Leukoencephalopathy	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells.
http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality	http://purl.obolibrary.org/obo/HP_0030178	Abnormality of central nervous system electrophysiology		Abnormality observed by electroencephalogram (EEG), which is used to record of the brain's spontaneous electrical activity from multiple electrodes placed on the scalp.
http://purl.obolibrary.org/obo/HP_0002356	Writer's cramp	http://purl.obolibrary.org/obo/HP_0004373	Focal dystonia		A focal dystonia of the fingers, hand, and/or forearm that appears when the affected person attempts to do a task that requires fine motor movements such as writing or playing a musical instrument.
http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		An abnormal pattern in the quality, quantity, or characteristics of sleep.
http://purl.obolibrary.org/obo/HP_0002361	Psychomotor deterioration	http://purl.obolibrary.org/obo/HP_0001268	Mental deterioration		Loss of previously present mental and motor abilities.
http://purl.obolibrary.org/obo/HP_0002362	Shuffling gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground.
http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		An anomaly of the brainstem.
http://purl.obolibrary.org/obo/HP_0002365	Hypoplasia of the brainstem	http://purl.obolibrary.org/obo/HP_0007362	Aplasia/Hypoplasia of the brainstem		Underdevelopment of the brainstem.
http://purl.obolibrary.org/obo/HP_0002366	Abnormal lower motor neuron morphology	http://purl.obolibrary.org/obo/HP_0002450	Abnormal motor neuron morphology		Any structural anomaly of the lower motor neuron.
http://purl.obolibrary.org/obo/HP_0002367	Visual hallucination	http://purl.obolibrary.org/obo/HP_0000738	Hallucinations		Visual perception in the absence of a visual stimulus.
http://purl.obolibrary.org/obo/HP_0002372	Normal interictal EEG	http://purl.obolibrary.org/obo/HP_0025373	Interictal EEG abnormality		Lack of observable abnormal electroencephalographic (EEG) patterns in an individual with a history of seizures. About half of individuals with epilepsy show interictal epileptiform discharges upon the first investigation. The yield can be increased by repeated studies, sleep studies, or by ambulatory EEG recordings over 24 hours. Normal interictal EEG is a sign that can be useful in the differential diagnosis.
http://purl.obolibrary.org/obo/HP_0002375	Hypokinesia	http://purl.obolibrary.org/obo/HP_0002374	Diminished movement		Abnormally diminished motor activity. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.
http://purl.obolibrary.org/obo/HP_0002376	Developmental regression	http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental abnormality		Loss of developmental skills, as manifested by loss of developmental milestones.
http://purl.obolibrary.org/obo/HP_0002378	Hand tremor	http://purl.obolibrary.org/obo/HP_0030188	Tremor by anatomical site		An unintentional, oscillating to-and-fro muscle movement affecting the hand.
http://purl.obolibrary.org/obo/HP_0002380	Fasciculations	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units.
http://purl.obolibrary.org/obo/HP_0002381	Aphasia	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		An acquired language impairment of some or all of the abilities to produce or comprehend speech and to read or write.
http://purl.obolibrary.org/obo/HP_0002383	Infectious encephalitis	http://purl.obolibrary.org/obo/HP_0011450	Unusual CNS infection		A disorder of the brain caused by an infectious agent that presents with fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity.
http://purl.obolibrary.org/obo/HP_0002384	Focal impaired awareness seizure	http://purl.obolibrary.org/obo/HP_0011146	Dialeptic seizure		Focal impaired awareness seizure (or focal seizure with impaired or lost awareness) is a type of focal-onset seizure characterized by some degree (which may be partial) of impairment of the person's awareness of themselves or their surroundings at any point during the seizure.
http://purl.obolibrary.org/obo/HP_0002385	Paraparesis	http://purl.obolibrary.org/obo/HP_0010551	Paraplegia/paraparesis		Weakness or partial paralysis in the lower limbs.
http://purl.obolibrary.org/obo/HP_0002389	Cavum septum pellucidum	http://purl.obolibrary.org/obo/HP_0007375	Abnormal septum pellucidum morphology		If the two laminae of the septum pellucidum are not fused then a fluid-filled space or cavum is present. The cavum septum pellucidum is present at birth but usually obliterates by the age of 3 to 6 months. It is up to 1cm in width and the walls are parallel. It is an enclosed space and is not part of the ventricular system or connected with the subarachnoid space.
http://purl.obolibrary.org/obo/HP_0002392	EEG with polyspike wave complexes	http://purl.obolibrary.org/obo/HP_0010850	EEG with spike-wave complexes		The presence of complexes of repetitive spikes and waves in EEG.
http://purl.obolibrary.org/obo/HP_0002395	Lower limb hyperreflexia	http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia		Increased intensity of the a reflex in the leg.
http://purl.obolibrary.org/obo/HP_0002396	Cogwheel rigidity	http://purl.obolibrary.org/obo/HP_0002063	Rigidity		A type of rigidity in which a muscle responds with cogwheellike jerks to the use of constant force in bending the limb (i.e., it gives way in little, repeated jerks when the muscle is passively stretched).
http://purl.obolibrary.org/obo/HP_0002401	Stroke-like episode	http://purl.obolibrary.org/obo/HP_0001297	Stroke		No consensus exists on what a stroke-like episode is, but these episodes can be functionally defined as a new neurological deficit, occurring with or without the context of seizures, which last longer than 24 hours.
http://purl.obolibrary.org/obo/HP_0002403	Positive Romberg sign	http://purl.obolibrary.org/obo/HP_0010831	Impaired proprioception		The patient stands with the feet placed together and balance and is asked to close his or her eyes. A loss of balance upon eye closure is a positive Romberg sign and is interpreted as indicating a deficit in proprioception.
http://purl.obolibrary.org/obo/HP_0002404	Thickened superior cerebellar peduncle	http://purl.obolibrary.org/obo/HP_0011932	Abnormal superior cerebellar peduncle morphology		Increased width of the superior cerebellar peduncle.
http://purl.obolibrary.org/obo/HP_0002406	Limb dysmetria	http://purl.obolibrary.org/obo/HP_0001310	Dysmetria		A type of dysmetria involving the limbs.
http://purl.obolibrary.org/obo/HP_0002408	Cerebral arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the brain.
http://purl.obolibrary.org/obo/HP_0002410	Aqueductal stenosis	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		Stenosis of the cerebral aqueduct (also known as the mesencephalic duct, aqueductus mesencephali, or aqueduct of Sylvius), which connects the third cerebral ventricle in the diencephalon to the fourth ventricle, which is between the pons and cerebellum.
http://purl.obolibrary.org/obo/HP_0002411	Myokymia	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Myokymia consists of involuntary, fine, continuous, undulating contractions that spread across the affected striated muscle.
http://purl.obolibrary.org/obo/HP_0002414	Spina bifida	http://purl.obolibrary.org/obo/HP_0010301	Spinal dysraphism		Incomplete closure of the embryonic neural tube, whereby some vertebral arches remain unfused and open. The mildest form is spina bifida occulta, followed by meningocele and meningomyelocele.
http://purl.obolibrary.org/obo/HP_0002415	Leukodystrophy	http://purl.obolibrary.org/obo/HP_0011400	Abnormal CNS myelination		Leukodystrophy refers to deterioration of white matter of the brain resulting from degeneration of myelin sheaths in the CNS. Their basic defect is directly related to the synthesis and maintenance of myelin membranes. Symmetric white matter involvement at MRI is a typical finding in patients with leukodystrophies.
http://purl.obolibrary.org/obo/HP_0002416	Subependymal cysts	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		Cerebral cysts, usually located in the wall of the caudate nucleus or in the caudothalamic groove. They are found in up to 5.2% of all neonates, using transfontanellar ultrasound in the first days of life.
http://purl.obolibrary.org/obo/HP_0002418	Abnormal midbrain morphology	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		An abnormality of the midbrain, which has as its parts the tectum, cerebral peduncle, midbrain tegmentum and cerebral aqueduct.
http://purl.obolibrary.org/obo/HP_0002419	Molar tooth sign on MRI	http://purl.obolibrary.org/obo/HP_0002418	Abnormal midbrain morphology		An abnormal appearance of the midbrain in axial magnetic resonance imaging in which the elongated superior cerebellar peduncles give the midbrain an appearance reminiscent of a molar or wisdom tooth.
http://purl.obolibrary.org/obo/HP_0002421	Poor head control	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Difficulty to maintain correct position of the head while standing or sitting. Infant head lag is observed when the head seems to flop around or lags posteriorly behind the trunk. Several articles have maintained that head lag should be absent by age 3 to 4 months.
http://purl.obolibrary.org/obo/HP_0002423	Long-tract sign	http://purl.obolibrary.org/obo/HP_0034482	Abnormal spinal cord physiology		Long-tract signs refer to symptoms that are attributable to the involvement of the long fiber tracts in the spinal cord, which connect the spinal cord to the brain and mediate spinal and motor functions. These include spasticity, hyperreflexia, and abnormal reflexes such as Babinski or Hoffman's sign. If possible, it is preferable to use the precise HPO terms for these abnormalities.
http://purl.obolibrary.org/obo/HP_0002425	Anarthria	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		A defect in the motor ability that enables speech.
http://purl.obolibrary.org/obo/HP_0002427	Expressive aphasia	http://purl.obolibrary.org/obo/HP_0002381	Aphasia		Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it.
http://purl.obolibrary.org/obo/HP_0002435	Meningocele	http://purl.obolibrary.org/obo/HP_0034238	Closed neural tube defect		Protrusion of the meninges through a defect of the skull or vertebral column.
http://purl.obolibrary.org/obo/HP_0002436	Occipital meningocele	http://purl.obolibrary.org/obo/HP_0002435	Meningocele		A herniation of meninges through a congenital bone defect in the skull in the occipital region.
http://purl.obolibrary.org/obo/HP_0002442	Dyscalculia	http://purl.obolibrary.org/obo/HP_0001328	Specific learning disability		A specific learning disability involving mathematics and arithmetic.
http://purl.obolibrary.org/obo/HP_0002444	Hypothalamic hamartoma	http://purl.obolibrary.org/obo/HP_0012286	Abnormal hypothalamus morphology		The presence of a hamartoma of the hypothalamus.
http://purl.obolibrary.org/obo/HP_0002445	Tetraplegia	http://purl.obolibrary.org/obo/HP_0030182	Tetraplegia/tetraparesis		Paralysis of all four limbs, and trunk of the body below the level of an associated injury to the spinal cord. The etiology of quadriplegia is similar to that of paraplegia except that the lesion is in the cervical spinal cord rather than in the thoracic or lumbar segments of the spinal cord.
http://purl.obolibrary.org/obo/HP_0002446	Astrocytosis	http://purl.obolibrary.org/obo/HP_0100707	Abnormal astrocyte morphology		Proliferation of astrocytes in the area of a lesion of the central nervous system.
http://purl.obolibrary.org/obo/HP_0002450	Abnormal motor neuron morphology	http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology		Any structural anomaly that affects the motor neuron.
http://purl.obolibrary.org/obo/HP_0002451	Limb dystonia	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the limbs.
http://purl.obolibrary.org/obo/HP_0002453	Abnormal globus pallidus morphology	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		An abnormality of the globus pallidus.
http://purl.obolibrary.org/obo/HP_0002454	Eye of the tiger anomaly of globus pallidus	http://purl.obolibrary.org/obo/HP_0012675	Iron accumulation in brain		The presence, on T2-weighted magnetic resonance imaging, of markedly low signal intensity of the globus pallidus that surrounds a central region of high signal intensity in the anteromedial globus pallidus, producing an eye-of-the-tiger appearance. The sign is thought to represent iron accumulation in the globus pallidus.
http://purl.obolibrary.org/obo/HP_0002460	Distal muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Reduced strength of the musculature of the distal extremities.
http://purl.obolibrary.org/obo/HP_0002461	Cerebellar dentate nucleus calcification	http://purl.obolibrary.org/obo/HP_0100321	Abnormal dentate nucleus morphology		Pathological deposition of calcium salts in the dentate nucleus of the cerebellum.
http://purl.obolibrary.org/obo/HP_0002463	Language impairment	http://purl.obolibrary.org/obo/HP_0034434	Abnormal communication		Language impairment is a deficit in comprehension or production of language that includes reduced vocabulary, limited sentence structure, or impairments in written or spoken communication. Language abilities are substantially and quantifiably below age expectations.
http://purl.obolibrary.org/obo/HP_0002464	Spastic dysarthria	http://purl.obolibrary.org/obo/HP_0001260	Dysarthria		A type of dysarthria related to bilateral damage of the upper motor neuron tracts of the pyramidal and extra- pyramidal tracts. Speech of affected individuals is slow, effortful, and has a harsh vocal quality.
http://purl.obolibrary.org/obo/HP_0002472	Small cerebral cortex	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		Reduced size of the cerebral cortex.
http://purl.obolibrary.org/obo/HP_0002474	Expressive language delay	http://purl.obolibrary.org/obo/HP_0000750	Delayed speech and language development		A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.
http://purl.obolibrary.org/obo/HP_0002475	Myelomeningocele	http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect		Protrusion of the meninges and portions of the spinal cord through a defect of the vertebral column.
http://purl.obolibrary.org/obo/HP_0002476	Primitive reflex	http://purl.obolibrary.org/obo/HP_0031826	Abnormal reflex		The primitive reflexes are a group of behavioral motor responses which are found in normal early development, are subsequently inhibited, but may be released from inhibition by cerebral, usually frontal, damage. They are thus part of a broader group of reflexes which reflect release phenomena, such as exaggerated stretch reflexes and extensor plantars. They do however involve more complex motor responses than such simple stretch reflexes, and are often a normal feature in the neonate or infant.
http://purl.obolibrary.org/obo/HP_0002480	Hepatic encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		Central nervous system dysfunction in association with liver failure and characterized clinically (depending on degree of severity) by lethargy, confusion, nystagmus, decorticate posturing, spasticity, and bilateral Babinski reflexes.
http://purl.obolibrary.org/obo/HP_0002486	Myotonia	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation.
http://purl.obolibrary.org/obo/HP_0002487	Hyperkinetic movements	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Motor hyperactivity with excessive movement of muscles of the body as a whole.
http://purl.obolibrary.org/obo/HP_0002488	Acute leukemia	http://purl.obolibrary.org/obo/HP_0001909	Leukemia		A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).
http://purl.obolibrary.org/obo/HP_0002490	Increased CSF lactate	http://purl.obolibrary.org/obo/HP_0030085	Abnormal CSF lactate concentration		Increased concentration of lactate in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0002491	Spasticity of facial muscles	http://purl.obolibrary.org/obo/HP_0001257	Spasticity		Spasticity of one or more muscles innervated by the facial nerve.
http://purl.obolibrary.org/obo/HP_0002492	Abnormal corticospinal tract morphology	http://purl.obolibrary.org/obo/HP_0002062	Abnormal pyramidal tract morphology		Abnormality of the corticospinal tract, which is the chief element of the pyramidal system (the principle motor tract) and is the only direct connection between the cerebrum and the spinal cord.
http://purl.obolibrary.org/obo/HP_0002493	Upper motor neuron dysfunction	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.
http://purl.obolibrary.org/obo/HP_0002494	Abnormal rapid eye movement sleep	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		Abnormality of REM Sleep are phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tone except for the eye and middle-ear muscles. There are also phases of rapid eye movements.
http://purl.obolibrary.org/obo/HP_0002495	Impaired vibratory sensation	http://purl.obolibrary.org/obo/HP_0010831	Impaired proprioception		A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.
http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology	http://purl.obolibrary.org/obo/HP_0010993	Abnormal cerebral subcortex morphology		An abnormality of the cerebral white matter.
http://purl.obolibrary.org/obo/HP_0002504	Calcification of the small brain vessels	http://purl.obolibrary.org/obo/HP_0031306	Intracranial arterial calcification		Deposition of calcium salts within small blood vessels of the brain.
http://purl.obolibrary.org/obo/HP_0002505	Loss of ambulation	http://purl.obolibrary.org/obo/HP_0002540	Inability to walk		Inability to walk in a person who previous had the ability to walk.
http://purl.obolibrary.org/obo/HP_0002506	Diffuse cerebral atrophy	http://purl.obolibrary.org/obo/HP_0002059	Cerebral atrophy		Diffuse unlocalised atrophy affecting the cerebrum.
http://purl.obolibrary.org/obo/HP_0002507	Semilobar holoprosencephaly	http://purl.obolibrary.org/obo/HP_0001360	Holoprosencephaly		A type of holoprosencephaly in which the left and right frontal and parietal lobes are fused and the interhemispheric fissure is only present posteriorly.
http://purl.obolibrary.org/obo/HP_0002508	Brainstem dysplasia	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		A developmental structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord.
http://purl.obolibrary.org/obo/HP_0002510	Spastic tetraplegia	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Spastic paralysis affecting all four limbs.
http://purl.obolibrary.org/obo/HP_0002511	Alzheimer disease	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads.
http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification	http://purl.obolibrary.org/obo/HP_0430048	Intracranial calcification		The presence of calcium deposition within the cerebrum.
http://purl.obolibrary.org/obo/HP_0002515	Waddling gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Weakness of the hip girdle and upper thigh muscles, for instance in myopathies, leads to an instability of the pelvis on standing and walking. If the muscles extending the hip joint are affected, the posture in that joint becomes flexed and lumbar lordosis increases. The patients usually have difficulties standing up from a sitting position. Due to weakness in the gluteus medius muscle, the hip on the side of the swinging leg drops with each step (referred to as Trendelenburg sign). The gait appears waddling. The patients frequently attempt to counteract the dropping of the hip on the swinging side by bending the trunk towards the side which is in the stance phase (in the German language literature this is referred to as Duchenne sign). Similar gait patterns can be caused by orthopedic conditions when the origin and the insertion site of the gluteus medius muscle are closer to each other than normal, for instance due to a posttraumatic elevation of the trochanter or pseudarthrosis of the femoral neck.
http://purl.obolibrary.org/obo/HP_0002516	Increased intracranial pressure	http://purl.obolibrary.org/obo/HP_0012640	Abnormality of intracranial pressure		An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0002518	Abnormal periventricular white matter morphology	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		A structural abnormality of the myelinated axons (white matter) located near the cerebral ventricles.
http://purl.obolibrary.org/obo/HP_0002519	Hypnagogic hallucination	http://purl.obolibrary.org/obo/HP_4000063	Sleep related hallucination		Hypnagogic hallucinations are brief hallucinations that occur when falling asleep.
http://purl.obolibrary.org/obo/HP_0002521	Hypsarrhythmia	http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges		Hypsarrhythmia is abnormal interictal high amplitude waves and a background of irregular spikes. There is continuous (during wakefulness), high-amplitude (>200 Hz), generalized polymorphic slowing with no organized background and multifocal spikes demonstrated by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0002522	Areflexia of lower limbs	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		Inability to elicit tendon reflexes in the lower limbs.
http://purl.obolibrary.org/obo/HP_0002524	Cataplexy	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions.
http://purl.obolibrary.org/obo/HP_0002526	Deficit in nonword repetition	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		Impaired ability to repeat non-word sounds. Nonword repetition (NWR) is a measure of short-term phonological memory.
http://purl.obolibrary.org/obo/HP_0002528	Granulovacuolar degeneration	http://purl.obolibrary.org/obo/HP_0002180	Neurodegeneration		Electron-dense granules within double membrane-bound cytoplasmic vacuoles.
http://purl.obolibrary.org/obo/HP_0002530	Axial dystonia	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		A type of dystonia that affects the midline muscles, i.e., the chest, abdominal, and back muscles.
http://purl.obolibrary.org/obo/HP_0002533	Abnormal posturing	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Involuntary flexion or extension of the arms and legs.
http://purl.obolibrary.org/obo/HP_0002536	Abnormal cortical gyration	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		An abnormality of the gyri (i.e., the ridges) of the cerebral cortex of the brain.
http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		Any structural abnormality of the cerebral cortex.
http://purl.obolibrary.org/obo/HP_0002539	Cortical dysplasia	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		The presence of developmental dysplasia of the cerebral cortex.
http://purl.obolibrary.org/obo/HP_0002540	Inability to walk	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Incapability to ambulate.
http://purl.obolibrary.org/obo/HP_0002542	Olivopontocerebellar atrophy	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		Neuronal degeneration in the cerebellum, pontine nuclei, and inferior olivary nucleus.
http://purl.obolibrary.org/obo/HP_0002544	Retrocollis	http://purl.obolibrary.org/obo/HP_0000473	Torticollis		A form of torticollis in which the head is drawn back, either due to a permanent contractures of neck extensor muscles, or to a spasmodic contracture.
http://purl.obolibrary.org/obo/HP_0002545	Patchy demyelination of subcortical white matter	http://purl.obolibrary.org/obo/HP_0007305	CNS demyelination		Patchy loss of myelin from nerve fibers in the central nervous system.
http://purl.obolibrary.org/obo/HP_0002548	Parkinsonism with favorable response to dopaminergic medication	http://purl.obolibrary.org/obo/HP_0001300	Parkinsonism		Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication.
http://purl.obolibrary.org/obo/HP_0002549	Deficit in phonologic short-term memory	http://purl.obolibrary.org/obo/HP_0033687	Short term memory impairment		Impaired ability to repeat non-word sounds. The test for nonword repetition involves the repetition of nonsensical words of increasing length and complexity and is regarded as a measure of phonological (speech sound) processing and short-term memory
http://purl.obolibrary.org/obo/HP_0002550	Absent facial hair	http://purl.obolibrary.org/obo/HP_0002298	Absent hair		Absence of facial hair.
http://purl.obolibrary.org/obo/HP_0002552	Trichodysplasia	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		Developmental dysplasia of the hair.
http://purl.obolibrary.org/obo/HP_0002553	Highly arched eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		Increased height of the central portion of the eyebrow, forming a crescent, semicircular, or inverted U shape.
http://purl.obolibrary.org/obo/HP_0002555	Absent pubic hair	http://purl.obolibrary.org/obo/HP_0100133	Abnormality of the pubic hair		Absence of pubic hair.
http://purl.obolibrary.org/obo/HP_0002557	Hypoplastic nipples	http://purl.obolibrary.org/obo/HP_0006709	Aplasia/Hypoplasia of the nipples		Underdevelopment of the nipple.
http://purl.obolibrary.org/obo/HP_0002558	Supernumerary nipple	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		Presence of more than two nipples.
http://purl.obolibrary.org/obo/HP_0002561	Absent nipple	http://purl.obolibrary.org/obo/HP_0006709	Aplasia/Hypoplasia of the nipples		Congenital failure to develop, and absence of, the nipple.
http://purl.obolibrary.org/obo/HP_0002562	Low-set nipples	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		Placement of the nipples at a lower than normal location.
http://purl.obolibrary.org/obo/HP_0002563	Constrictive pericarditis	http://purl.obolibrary.org/obo/HP_0001701	Pericarditis		Presence of a thickened, fibrotic pericardium that forms a non-compliant shell around the heart, and resulting from chronic inflammation of the pericardium.
http://purl.obolibrary.org/obo/HP_0002566	Intestinal malrotation	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		An abnormality of the intestinal rotation and fixation that normally occurs during the development of the gut. This can lead to volvulus, or twisting of the intestine that causes obstruction and necrosis.
http://purl.obolibrary.org/obo/HP_0002570	Steatorrhea	http://purl.obolibrary.org/obo/HP_0002630	Fat malabsorption		Greater than normal amounts of fat in the feces. This is a result of malabsorption of lipids in the small intestine and results in frothy foul-smelling fecal matter that floats.
http://purl.obolibrary.org/obo/HP_0002571	Achalasia	http://purl.obolibrary.org/obo/HP_0031857	Ineffective esophageal peristalsis		A disorder of esophageal motility characterized by the inability of the lower esophageal sphincter to relax during swallowing and by inadequate or lacking peristalsis in the lower half of the body of the esophagus.
http://purl.obolibrary.org/obo/HP_0002572	Episodic vomiting	http://purl.obolibrary.org/obo/HP_0002013	Vomiting		Paroxysmal, recurrent episodes of vomiting.
http://purl.obolibrary.org/obo/HP_0002574	Episodic abdominal pain	http://purl.obolibrary.org/obo/HP_0032148	Episodic pain		An intermittent form of abdominal pain.
http://purl.obolibrary.org/obo/HP_0002575	Tracheoesophageal fistula	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		An abnormal connection (fistula) between the esophagus and the trachea.
http://purl.obolibrary.org/obo/HP_0002576	Intussusception	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		An abnormality of the intestine in which part of the intestine invaginates (telescopes) into another part of the intestine.
http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		An abnormality of the stomach.
http://purl.obolibrary.org/obo/HP_0002578	Gastroparesis	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		Decreased strength of the muscle layer of stomach, which leads to a decreased ability to empty the contents of the stomach despite the absence of obstruction.
http://purl.obolibrary.org/obo/HP_0002579	Gastrointestinal dysmotility	http://purl.obolibrary.org/obo/HP_0030895	Abnormal gastrointestinal motility		Abnormal intestinal contractions, such as spasms and intestinal paralysis, related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes.
http://purl.obolibrary.org/obo/HP_0002580	Volvulus	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		Abnormal twisting of a portion of intestine around itself or around a stalk of mesentery tissue.
http://purl.obolibrary.org/obo/HP_0002582	Atrophic gastritis	http://purl.obolibrary.org/obo/HP_0005263	Gastritis		Atrophic gastritis (AG) is a histopathological entity that is characterized by chronic inflammation of the gastric mucosa with loss of gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue.
http://purl.obolibrary.org/obo/HP_0002583	Colitis	http://purl.obolibrary.org/obo/HP_0002037	Inflammation of the large intestine		Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases.
http://purl.obolibrary.org/obo/HP_0002585	Abnormal peritoneum morphology	http://purl.obolibrary.org/obo/HP_0002012	Abnormality of the abdominal organs		An abnormality of the peritoneum.
http://purl.obolibrary.org/obo/HP_0002586	Peritonitis	http://purl.obolibrary.org/obo/HP_0045073	Serositis		Inflammation of the peritoneum.
http://purl.obolibrary.org/obo/HP_0002587	Projectile vomiting	http://purl.obolibrary.org/obo/HP_0002013	Vomiting		Vomiting that ejects the gastric contents with great force.
http://purl.obolibrary.org/obo/HP_0002588	Duodenal ulcer	http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer		An erosion of the mucous membrane in a portion of the duodenum.
http://purl.obolibrary.org/obo/HP_0002591	Polyphagia	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat.
http://purl.obolibrary.org/obo/HP_0002592	Gastric ulcer	http://purl.obolibrary.org/obo/HP_0004398	Peptic ulcer		An ulcer, that is, an erosion of an area of the gastric mucous membrane.
http://purl.obolibrary.org/obo/HP_0002593	Intestinal lymphangiectasia	http://purl.obolibrary.org/obo/HP_0031842	Lymphangiectasis		Angiectasia of lymph vessels (i.e., dilatation of lymphatic vessels) in the intestines.
http://purl.obolibrary.org/obo/HP_0002594	Pancreatic hypoplasia	http://purl.obolibrary.org/obo/HP_0100800	Aplasia/Hypoplasia of the pancreas		Hypoplasia of the pancreas.
http://purl.obolibrary.org/obo/HP_0002595	Ileus	http://purl.obolibrary.org/obo/HP_0005214	Intestinal obstruction		Acute obstruction of the intestines preventing passage of the contents of the intestines.
http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the vasculature	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of the cardiovascular system		An abnormality of the vasculature.
http://purl.obolibrary.org/obo/HP_0002599	Head titubation	http://purl.obolibrary.org/obo/HP_0030187	Titubation		A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction.
http://purl.obolibrary.org/obo/HP_0002600	Hyporeflexia of lower limbs	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		Reduced intensity of muscle tendon reflexes in the lower limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping.
http://purl.obolibrary.org/obo/HP_0002604	Gastrointestinal telangiectasia	http://purl.obolibrary.org/obo/HP_0100579	Mucosal telangiectasiae		Telangiectasia affecting the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0002605	Hepatic necrosis	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		The presence of cell death (necrosis) affecting the liver.
http://purl.obolibrary.org/obo/HP_0002608	Celiac disease	http://purl.obolibrary.org/obo/HP_0100326	Immunologic hypersensitivity		Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurrence of CD is seen as a feature of a number of other diseases.
http://purl.obolibrary.org/obo/HP_0002612	Congenital hepatic fibrosis	http://purl.obolibrary.org/obo/HP_0001395	Hepatic fibrosis		The presence of fibrosis of that part of the liver with congenital onset.
http://purl.obolibrary.org/obo/HP_0002613	Biliary cirrhosis	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Progressive destruction of the small-to-medium bile ducts of the intrahepatic biliary tree, which leads to progressive cholestasis and often end-stage liver disease.
http://purl.obolibrary.org/obo/HP_0002614	Hepatic periportal necrosis	http://purl.obolibrary.org/obo/HP_0002605	Hepatic necrosis		A type of hepatic necrosis that is concentrated around the necrosis of hepatocytes localized around the intrahepatic branch of portal vein.
http://purl.obolibrary.org/obo/HP_0002616	Aortic root aneurysm	http://purl.obolibrary.org/obo/HP_0012727	Thoracic aortic aneurysm		An abnormal localized widening (dilatation) of the aortic root.
http://purl.obolibrary.org/obo/HP_0002617	Vascular dilatation	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		An abnormal increase in the diameter of an artery or vein, either as a diffuse dilatation or as a localized, sac-like outpouching of the vessel wall (aneurysm).
http://purl.obolibrary.org/obo/HP_0002619	Varicose veins	http://purl.obolibrary.org/obo/HP_0005293	Venous insufficiency		Enlarged and tortuous veins.
http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis	http://purl.obolibrary.org/obo/HP_0002634	Arteriosclerosis		A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow.
http://purl.obolibrary.org/obo/HP_0002623	Overriding aorta	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		An overriding aorta is a congenital heart defect where the aorta is positioned directly over a ventricular septal defect, instead of over the left ventricle. The result is that the aorta receives some blood from the right ventricle, which reduces the amount of oxygen in the blood. It is one of the four conditions of the Tetralogy of Fallot. The aortic root can be displaced toward the front (anteriorly) or directly above the septal defect, but it is always abnormally located to the right of the root of the pulmonary artery. The degree of override is quite variable, with 5-95% of the valve being connected to the right ventricle.
http://purl.obolibrary.org/obo/HP_0002624	Abnormal venous morphology	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		An anomaly of vein.
http://purl.obolibrary.org/obo/HP_0002625	Deep venous thrombosis	http://purl.obolibrary.org/obo/HP_0004936	Venous thrombosis		Formation of a blot clot in a deep vein. The clot often blocks blood flow, causing swelling and pain. The deep veins of the leg are most often affected.
http://purl.obolibrary.org/obo/HP_0002626	Venous varicosities of celiac and mesenteric vessels	http://purl.obolibrary.org/obo/HP_0002619	Varicose veins		Elongated and tortuous mesenteric veins, which comprise the inferior mesenteric vein and the superior mesenteric vein.
http://purl.obolibrary.org/obo/HP_0002627	Right aortic arch with mirror image branching	http://purl.obolibrary.org/obo/HP_0012020	Right aortic arch		The aortic arch crosses the right mainstem bronchus and not the left mainstem bronchus, but does not result in the creation of a vascular ring. The first branch is the left brachiocephalic artery which divides into the left carotid artery and left subclavian artery, the second branch is the right carotid artery, the third branch is the right subclavian artery.
http://purl.obolibrary.org/obo/HP_0002629	Gastrointestinal arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0002630	Fat malabsorption	http://purl.obolibrary.org/obo/HP_0002024	Malabsorption		Abnormality of the absorption of fat from the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0002634	Arteriosclerosis	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity.
http://purl.obolibrary.org/obo/HP_0002635	Type IV atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0031678	Atherosclerotic lesion		In type IV atherosclerotic lesions a dense accumulation of extracellular lipid occupies an extensive but well-defined region of the intima. This type of extracellular lipid accumulation is known as the lipid core. A fibrous tissue increase is not a feature, and complications such as defects of the lesion surface and thrombosis are not present. The type IV lesion is also known as atheroma. Type IV is the first lesion considered advanced in this classification because of the severe intimal disorganization caused by the lipid core. The characteristic core appears to develop from an increase and the consequent confluence of the small isolated pools of extracellular lipid that characterize type III lesions. The increase in lipid is believed to result from continued insudation from the plasma. Type IV lesions, when they first appear in younger people, are found in the same locations as adaptive intimal thickenings of the eccentric type. Thus, atheroma is, at least initially, an eccentric lesion.
http://purl.obolibrary.org/obo/HP_0002636	Dilatation of an abdominal artery	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Abnormal outpouching or sac-like dilatation in an artery that originates from the abdominal aorta.
http://purl.obolibrary.org/obo/HP_0002637	Cerebral ischemia	http://purl.obolibrary.org/obo/HP_0033401	Tissue ischemia		Restriction of arterial blood supply to the brain associated with insufficient oxygenation to support the metabolic requirements of the tissue.
http://purl.obolibrary.org/obo/HP_0002638	Superficial thrombophlebitis	http://purl.obolibrary.org/obo/HP_0004418	Thrombophlebitis		Inflammation of a superficial vein associated with venous thrombosis (blood clot formation within the vein).
http://purl.obolibrary.org/obo/HP_0002639	Budd-Chiari syndrome	http://purl.obolibrary.org/obo/HP_0030846	Abnormality of venous physiology		Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow at any level from the small hepatic veins to the junction of the inferior vena cava (IVC) with the right atrium, 1 and occurs in 1/100,000 of the general population worldwide. The most common presentation is with ascites, but can range from fulminant hepatic failure (FHF) to asymptomatic forms. Obstruction of hepatic venous outflow is mainly caused by primary intravascular thrombosis, which can occur suddenly or be repeated over time, accompanied by some revascularization, accounting for the variable parenchymal hepatic damage and histologic presentation. Budd-Chiari syndrome is thus a disease, but since it occurs as a manifestation of several other diseases, this term is kept for the present for convenience.
http://purl.obolibrary.org/obo/HP_0002640	Hypertension associated with pheochromocytoma	http://purl.obolibrary.org/obo/HP_0000822	Hypertension		A type of hypertension associated with pheochromocytoma.
http://purl.obolibrary.org/obo/HP_0002643	Neonatal respiratory distress	http://purl.obolibrary.org/obo/HP_0002093	Respiratory insufficiency		Respiratory difficulty as newborn.
http://purl.obolibrary.org/obo/HP_0002644	Abnormal pelvic girdle bone morphology	http://purl.obolibrary.org/obo/HP_0011844	Abnormal appendicular skeleton morphology		An abnormality of the bony pelvic girdle, which is a ring of bones connecting the vertebral column to the femurs.
http://purl.obolibrary.org/obo/HP_0002645	Wormian bones	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		The presence of extra bones within a cranial suture. Wormian bones are irregular isolated bones which appear in addition to the usual centers of ossification of the cranium.
http://purl.obolibrary.org/obo/HP_0002647	Aortic dissection	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta.
http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		A general term describing features characterized by abnormal development of bones and connective tissues.
http://purl.obolibrary.org/obo/HP_0002655	Spondyloepiphyseal dysplasia	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		A disorder of bone growth affecting the vertebrae and the ends of the long bones (epiphyses).
http://purl.obolibrary.org/obo/HP_0002659	Increased susceptibility to fractures	http://purl.obolibrary.org/obo/HP_0011843	Abnormal musculoskeletal physiology		An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture.
http://purl.obolibrary.org/obo/HP_0002661	Painless fractures due to injury	http://purl.obolibrary.org/obo/HP_0010832	Abnormality of pain sensation		An increased tendency to fractures following trauma, with fractures occurring without pain.
http://purl.obolibrary.org/obo/HP_0002664	Neoplasm	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
http://purl.obolibrary.org/obo/HP_0002665	Lymphoma	http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm		A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells.
http://purl.obolibrary.org/obo/HP_0002666	Pheochromocytoma	http://purl.obolibrary.org/obo/HP_0100634	Neuroendocrine neoplasm		Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines.
http://purl.obolibrary.org/obo/HP_0002667	Nephroblastoma	http://purl.obolibrary.org/obo/HP_0011794	Embryonal renal neoplasm		The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children.
http://purl.obolibrary.org/obo/HP_0002668	Paraganglioma	http://purl.obolibrary.org/obo/HP_0100634	Neuroendocrine neoplasm		A carotid body tumor (also called paraganglionoma or chemodectoma) is a tumor found in the upper neck at the branching of the carotid artery. They arise from the chemoreceptor organ (paraganglion) located in the adventitia of the carotid artery bifurcation.
http://purl.obolibrary.org/obo/HP_0002669	Osteosarcoma	http://purl.obolibrary.org/obo/HP_0100242	Sarcoma		A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.
http://purl.obolibrary.org/obo/HP_0002671	Basal cell carcinoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		The presence of a basal cell carcinoma of the skin.
http://purl.obolibrary.org/obo/HP_0002673	Coxa valga	http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology		Coxa valga is a deformity of the hip in which the angle between the femoral shaft and the femoral neck is increased compared to age-adjusted values (about 150 degrees in newborns gradually reducing to 120-130 degrees in adults).
http://purl.obolibrary.org/obo/HP_0002676	Cloverleaf skull	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Trilobar skull configuration when viewed from the front or behind.
http://purl.obolibrary.org/obo/HP_0002677	Small foramen magnum	http://purl.obolibrary.org/obo/HP_0002699	Abnormal foramen magnum morphology		An abnormal narrowing of the foramen magnum.
http://purl.obolibrary.org/obo/HP_0002679	Abnormal sella turcica morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		Abnormality of the sella turcica, a saddle-shaped depression in the sphenoid bone at the base of the human skull.
http://purl.obolibrary.org/obo/HP_0002680	J-shaped sella turcica	http://purl.obolibrary.org/obo/HP_0002681	Deformed sella turcica		A deformity of the sella turcica whereby the sella extends further anterior than normal such that the anterior clinoid process appears to overhang it, giving the appearance of the letter J on imaging of the skull.
http://purl.obolibrary.org/obo/HP_0002682	Broad skull	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Increased width of the skull.
http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		Abnormality of the morphology (structure) of the calvaria (skullcap), that is, of that part of the skull that is made up of the superior portions of the frontal bone, occipital bone, and parietal bones and covers the cranial cavity that contains the brain.
http://purl.obolibrary.org/obo/HP_0002684	Thickened calvaria	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		The presence of an abnormally thick calvaria.
http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Medical history of maternal diseases, exposures, or other relevant findings during the pregnancy of which the index person was the product.
http://purl.obolibrary.org/obo/HP_0002687	Abnormality of frontal sinus	http://purl.obolibrary.org/obo/HP_0000245	Abnormal paranasal sinus morphology		An abnormality of the frontal sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The frontal sinus is located within the frontal bone.
http://purl.obolibrary.org/obo/HP_0002688	Absent frontal sinuses	http://purl.obolibrary.org/obo/HP_0009119	Aplasia/Hypoplasia of the frontal sinuses		Aplasia of frontal sinus.
http://purl.obolibrary.org/obo/HP_0002689	Absent paranasal sinuses	http://purl.obolibrary.org/obo/HP_0005453	Absent/hypoplastic paranasal sinuses		Aplasia of the paranasal sinuses.
http://purl.obolibrary.org/obo/HP_0002690	Large sella turcica	http://purl.obolibrary.org/obo/HP_0002679	Abnormal sella turcica morphology		An abnormal enlargement of the sella turcica.
http://purl.obolibrary.org/obo/HP_0002691	Platybasia	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		A developmental malformation of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward such that there is an abnormal flattening of the skull base.
http://purl.obolibrary.org/obo/HP_0002693	Abnormal skull base morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		An abnormality of the base of the skull, which forms the floor of the cranial cavity and separates the brain from other facial structures. The skull base is made up of five bones: the ethmoid, sphenoid, occipital, paired frontal, and paired parietal bones, and is subdivided into 3 regions: the anterior, middle, and posterior cranial fossae. The petro-occipital fissure subdivides the middle cranial fossa into 1 central component and 2 lateral components.
http://purl.obolibrary.org/obo/HP_0002694	Sclerosis of skull base	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Increased bone density of the skull base without significant changes in bony contour.
http://purl.obolibrary.org/obo/HP_0002696	Abnormal parietal bone morphology	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Any abnormality of the parietal bone of the skull.
http://purl.obolibrary.org/obo/HP_0002697	Parietal foramina	http://purl.obolibrary.org/obo/HP_0002696	Abnormal parietal bone morphology		The presence of symmetrical and circular openings (foramina) in the parietal bone ranging in size from a few millimeters to several centimeters wide.
http://purl.obolibrary.org/obo/HP_0002699	Abnormal foramen magnum morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		Any abnormality of the foramen magnum.
http://purl.obolibrary.org/obo/HP_0002700	Large foramen magnum	http://purl.obolibrary.org/obo/HP_0002699	Abnormal foramen magnum morphology		An abnormal increase in the size of the foramen magnum.
http://purl.obolibrary.org/obo/HP_0002703	Abnormality of skull ossification	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		An abnormality of the process of ossification of the skull.
http://purl.obolibrary.org/obo/HP_0002705	High, narrow palate	http://purl.obolibrary.org/obo/HP_0000218	High palate		The presence of a high and narrow palate.
http://purl.obolibrary.org/obo/HP_0002707	Palate telangiectasia	http://purl.obolibrary.org/obo/HP_0000228	Oral cavity telangiectasia		The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the palate.
http://purl.obolibrary.org/obo/HP_0002708	Prominent median palatal raphe	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		Unusual prominence of the median palatal raphe, which is the ridge formed by the fusion of the two plates of the skull that form the hard palate.
http://purl.obolibrary.org/obo/HP_0002710	Commissural lip pit	http://purl.obolibrary.org/obo/HP_0100267	Lip pit		A depression located at an oral commissure.
http://purl.obolibrary.org/obo/HP_0002711	Exaggerated median tongue furrow	http://purl.obolibrary.org/obo/HP_0000221	Furrowed tongue		Increased depth of the median tongue furrow.
http://purl.obolibrary.org/obo/HP_0002714	Downturned corners of mouth	http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape		A morphological abnormality of the mouth in which the angle of the mouth is downturned. The oral commissures are positioned inferior to the midline labial fissure.
http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the immune system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the immune system.
http://purl.obolibrary.org/obo/HP_0002718	Recurrent bacterial infections	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		Increased susceptibility to bacterial infections as manifested by recurrent episodes of bacterial infection.
http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		Increased susceptibility to infections as manifested by repeated bouts of infection.
http://purl.obolibrary.org/obo/HP_0002720	Decreased circulating IgA concentration	http://purl.obolibrary.org/obo/HP_0410240	Abnormal circulating IgA concentration		Decreased levels of immunoglobulin A (IgA).
http://purl.obolibrary.org/obo/HP_0002722	Recurrent abscess formation	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		An increased susceptibility to abscess formation, as manifested by a medical history of recurrent abscesses.
http://purl.obolibrary.org/obo/HP_0002723	Absence of bactericidal oxidative respiratory burst in phagocytes	http://purl.obolibrary.org/obo/HP_0010977	Abnormal phagocytosis		An absence of the phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.
http://purl.obolibrary.org/obo/HP_0002724	Recurrent Aspergillus infection	http://purl.obolibrary.org/obo/HP_5210099	Unusual Aspergillus infection		Increased susceptibility to Aspergillus infections as manifested by recurrent episodes of Aspergillus infection.
http://purl.obolibrary.org/obo/HP_0002726	Recurrent Staphylococcus aureus infection	http://purl.obolibrary.org/obo/HP_5210003	Unusual Staphylococcus aureus infection		Increased susceptibility to Staphylococcus aureus infections as manifested by recurrent episodes of Staphylococcus aureus infection.
http://purl.obolibrary.org/obo/HP_0002728	Recurrent mucocutaneous candidiasis	http://purl.obolibrary.org/obo/HP_5210236	Unusual fungal skin infection		Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails.
http://purl.obolibrary.org/obo/HP_0002729	Follicular hyperplasia	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Lymphadenopathy (enlargement of lymph nodes) owing to hyperplasia of follicular (germinal) centers.
http://purl.obolibrary.org/obo/HP_0002730	Chronic noninfectious lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		A chronic form of lymphadenopathy that is not related to infection.
http://purl.obolibrary.org/obo/HP_0002731	Decreased T cell apoptosis	http://purl.obolibrary.org/obo/HP_0030886	Abnormal T cell apoptosis		Abnormal decrease of apoptosis by peripheral blood T cells in an in vitro culture, compared to a healthy control sample. May be either spontaneous, induced by UV, X-ray, FasL or other agens. Commonly measured by surface expression of phosphatidyl serine labelled by Annexin V, but other methods such as staning of cleaved Caspases may be used by different laboratories.
http://purl.obolibrary.org/obo/HP_0002732	Lymph node hypoplasia	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		Underdevelopment of the lymph nodes.
http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology	http://purl.obolibrary.org/obo/HP_0100763	Abnormality of the lymphatic system		A structural lymph node abnormality.
http://purl.obolibrary.org/obo/HP_0002738	Hypoplastic frontal sinuses	http://purl.obolibrary.org/obo/HP_0009119	Aplasia/Hypoplasia of the frontal sinuses		Underdevelopment of frontal sinus.
http://purl.obolibrary.org/obo/HP_0002740	Recurrent Escherichia coli infection	http://purl.obolibrary.org/obo/HP_5210091	Unusual Escherichia coli infection		Increased susceptibility to Escherichia coli infections as manifested by recurrent episodes of Escherichia coli infection.
http://purl.obolibrary.org/obo/HP_0002741	Recurrent Serratia infection	http://purl.obolibrary.org/obo/HP_5210046	Unusual Serratia infection		Increased susceptibility to Serratia infections as manifested by recurrent episodes of Serratia infection.
http://purl.obolibrary.org/obo/HP_0002742	Recurrent Klebsiella infection	http://purl.obolibrary.org/obo/HP_5210040	Unusual Klebsiella infection		Increased susceptibility to Klebsiella infections as manifested by recurrent episodes of Klebsiella infection.
http://purl.obolibrary.org/obo/HP_0002743	Recurrent enteroviral infections	http://purl.obolibrary.org/obo/HP_0004429	Recurrent viral infections		Increased susceptibility to enteroviral infections as manifested by recurrent episodes of enteroviral infection.
http://purl.obolibrary.org/obo/HP_0002745	Oral leukoplakia	http://purl.obolibrary.org/obo/HP_0025125	White lesion of the oral mucosa		A thickened white patch on the oral mucosa that cannot be rubbed off.
http://purl.obolibrary.org/obo/HP_0002748	Rickets	http://purl.obolibrary.org/obo/HP_0004349	Reduced bone mineral density		Rickets is divided into two major categories including calcipenic and phosphopenic. Hypophosphatemia is described as a common manifestation of both categories. Hypophosphatemic rickets is the most common type of rickets that is characterized by low levels of serum phosphate, resistance to ultraviolet radiation or vitamin D intake. There are several issues involved in hypophosphatemic rickets such as calcium, vitamin D, phosphorus deficiencies. Moreover, other disorder can be associated with its occurrence such as absorption defects due to pancreatic, intestinal, gastric, and renal disorders and hepatobiliary disease. Symptoms are usually seen in childhood and can be varied in severity. Severe forms may be linked to bowing of the legs, poor bone growth, and short stature as well as joint and bone pain. Hypophosphatemic rickets are associated with renal excretion of phosphate, hypophosphatemia, and mineral defects in bones. The familial type of the disease is the most common type of rickets.
http://purl.obolibrary.org/obo/HP_0002749	Osteomalacia	http://purl.obolibrary.org/obo/HP_0004349	Reduced bone mineral density		Osteomalacia is a general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets.
http://purl.obolibrary.org/obo/HP_0002750	Delayed skeletal maturation	http://purl.obolibrary.org/obo/HP_0000927	Abnormality of skeletal maturation		A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.
http://purl.obolibrary.org/obo/HP_0002751	Kyphoscoliosis	http://purl.obolibrary.org/obo/HP_0002650	Scoliosis		An abnormal curvature of the spine in both a coronal (lateral) and sagittal (back-to-front) plane.
http://purl.obolibrary.org/obo/HP_0002753	Thin bony cortex	http://purl.obolibrary.org/obo/HP_0003103	Abnormal cortical bone morphology		Abnormal thinning of the cortical region of bones.
http://purl.obolibrary.org/obo/HP_0002756	Pathologic fracture	http://purl.obolibrary.org/obo/HP_0002659	Increased susceptibility to fractures		A pathologic fracture occurs when a bone breaks in an area that is weakened secondarily to another disease process such as tumor, infection, and certain inherited bone disorders. A pathologic fracture can occur without a degree of trauma required to cause fracture in healthy bone.
http://purl.obolibrary.org/obo/HP_0002757	Recurrent fractures	http://purl.obolibrary.org/obo/HP_0002659	Increased susceptibility to fractures		The repeated occurrence of bone fractures (implying an abnormally increased tendency for fracture).
http://purl.obolibrary.org/obo/HP_0002758	Osteoarthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		Degeneration (wear and tear) of articular cartilage, i.e., of the joint surface. Joint degeneration may be accompanied by osteophytes (bone overgrowth), narrowing of the joint space, regions of sclerosis at the joint surface, or joint deformity.
http://purl.obolibrary.org/obo/HP_0002761	Generalized joint hypermobility	http://purl.obolibrary.org/obo/HP_0001382	Joint hypermobility		Joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body. In individuals with Joint hypermobility at multiple sites (usually five or more), the term generalized joint hypermobility is preferred.
http://purl.obolibrary.org/obo/HP_0002762	Multiple exostoses	http://purl.obolibrary.org/obo/HP_0100777	Exostoses		Presence of more than one exostosis. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.
http://purl.obolibrary.org/obo/HP_0002763	Abnormal cartilage morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Any morphological abnormality of cartilage.
http://purl.obolibrary.org/obo/HP_0002764	Stippled chondral calcification	http://purl.obolibrary.org/obo/HP_0100593	Calcification of cartilage		Punctate (speckled, dot-like) deposition of calcium of calcium salts in the articular cartilage (cartilage located in joints).
http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology	http://purl.obolibrary.org/obo/HP_0005607	Abnormal tracheobronchial morphology		A structural anomaly of the trachea.
http://purl.obolibrary.org/obo/HP_0002780	Bronchomalacia	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Weakness or softness of the cartilage in the walls of the bronchial tubes.
http://purl.obolibrary.org/obo/HP_0002781	Upper airway obstruction	http://purl.obolibrary.org/obo/HP_0006536	Airway obstruction		Increased resistance to the passage of air in the upper airway.
http://purl.obolibrary.org/obo/HP_0002783	Recurrent lower respiratory tract infections	http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections		An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections.
http://purl.obolibrary.org/obo/HP_0002786	Tracheobronchomalacia	http://purl.obolibrary.org/obo/HP_0002780	Bronchomalacia		Weakness of the cartilage in the trachea and the bronchi, resulting in a floppy (non-rigid) airway. Affected persons may have difficulties to maintain patency of the airways.
http://purl.obolibrary.org/obo/HP_0002787	Tracheal calcification	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		Calcification (abnormal deposits of calcium) in the tracheal tissues.
http://purl.obolibrary.org/obo/HP_0002788	Recurrent upper respiratory tract infections	http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections		An increased susceptibility to upper respiratory tract infections as manifested by a history of recurrent upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).
http://purl.obolibrary.org/obo/HP_0002791	Hypoventilation	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		A reduction in the amount of air transported into the pulmonary alveoli by breathing, leading to hypercapnia (increase in the partial pressure of carbon dioxide).
http://purl.obolibrary.org/obo/HP_0002792	Reduced vital capacity	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		An abnormal reduction on the vital capacity, which is defined as the total lung capacity (volume of air in the lungs at maximal inflation) less the residual volume (i.e., volume of air in the lungs following maximal exhalation) of the lung.
http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		An anomaly of the rhythm or depth of breathing.
http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the respiratory system		Abnormal function of the respiratory system.
http://purl.obolibrary.org/obo/HP_0002797	Osteolysis	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium.
http://purl.obolibrary.org/obo/HP_0002803	Congenital contracture	http://purl.obolibrary.org/obo/HP_0001371	Flexion contracture		One or more flexion contractures (a bent joint that cannot be straightened actively or passively) that are present at birth.
http://purl.obolibrary.org/obo/HP_0002804	Arthrogryposis multiplex congenita	http://purl.obolibrary.org/obo/HP_0002803	Congenital contracture		Multiple congenital contractures in different body areas.
http://purl.obolibrary.org/obo/HP_0002808	Kyphosis	http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column		Exaggerated anterior convexity of the thoracic vertebral column.
http://purl.obolibrary.org/obo/HP_0002813	Abnormal limb bone morphology	http://purl.obolibrary.org/obo/HP_0040068	Abnormality of limb bone		Any abnormality of bones of the arms or legs.
http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		An abnormality of the leg.
http://purl.obolibrary.org/obo/HP_0002815	Abnormality of the knee	http://purl.obolibrary.org/obo/HP_0100491	Abnormality of lower limb joint		An abnormality of the knee joint or surrounding structures.
http://purl.obolibrary.org/obo/HP_0002816	Genu recurvatum	http://purl.obolibrary.org/obo/HP_0010500	Hyperextensibility of the knee		An abnormally increased extension of the knee joint, so that the knee can bend backwards.
http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		An abnormality of the arm.
http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		An abnormality of the radius.
http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		Any anomaly of the structure of the femur.
http://purl.obolibrary.org/obo/HP_0002825	Caudal appendage	http://purl.obolibrary.org/obo/HP_0008519	Abnormal coccyx morphology		The presence of a tail-like skin appendage located adjacent to the sacrum.
http://purl.obolibrary.org/obo/HP_0002826	Halberd-shaped pelvis	http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology		An anomalous radiographic appearance of the developing pelvis, in which the greater ischiadic noth (incisura ischiadica major) is shallow and the pelvis takes on the appearance said to resemble a halberd (a weapon especially of the 15th and 16th centuries consisting typically of a battle-ax and pike mounted on a handle).
http://purl.obolibrary.org/obo/HP_0002827	Hip dislocation	http://purl.obolibrary.org/obo/HP_0030311	Lower extremity joint dislocation		Displacement of the femur from its normal location in the hip joint.
http://purl.obolibrary.org/obo/HP_0002832	Calcific stippling	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs).
http://purl.obolibrary.org/obo/HP_0002833	Cystic angiomatosis of bone	http://purl.obolibrary.org/obo/HP_0012062	Bone cyst		Disseminated multifocal hemangiomatous or lymphangiomatous lesions of the skeleton. The lesions are lytic, well-defined, round or oval lesions within the medullary cavity, and they have an intact cortex, and manifest variable peripheral sclerosis and may exhibit endosteal scalloping.
http://purl.obolibrary.org/obo/HP_0002835	Aspiration	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Inspiration of a foreign object into the airway.
http://purl.obolibrary.org/obo/HP_0002836	Bladder exstrophy	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Eversion of the posterior bladder wall through the congenitally absent lower anterior abdominal wall and anterior bladder wall.
http://purl.obolibrary.org/obo/HP_0002837	Recurrent bronchitis	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		An increased susceptibility to bronchitis as manifested by a history of recurrent bronchitis.
http://purl.obolibrary.org/obo/HP_0002839	Urinary bladder sphincter dysfunction	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Abnormal function of a sphincter of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0002841	Recurrent fungal infections	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		Increased susceptibility to fungal infections as manifested by multiple episodes of fungal infection.
http://purl.obolibrary.org/obo/HP_0002843	Abnormal T cell morphology	http://purl.obolibrary.org/obo/HP_0004332	Abnormal lymphocyte morphology		Abnormal increase or decrease of total or subset T cell count. T cells are commonly characterized as CD3+ lymphocytes, or their subpopulations, in the blood, compared to a reference range for a given sex and age-group, measured ex vivo. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_0002846	Abnormal B cell morphology	http://purl.obolibrary.org/obo/HP_0004332	Abnormal lymphocyte morphology		A structural abnormality of B cells.
http://purl.obolibrary.org/obo/HP_0002847	Impaired memory B cell generation	http://purl.obolibrary.org/obo/HP_0005372	Abnormal B cell physiology		Impaired production of memory cells, the B cells that persist for years or an entire lifetime and which confer rapid and enhanced response to secondary challenge.
http://purl.obolibrary.org/obo/HP_0002848	Decreased specific anti-polysaccharide antibody concentration	http://purl.obolibrary.org/obo/HP_0012475	Impaired specific antibody response		The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against bacterial polysaccharides.
http://purl.obolibrary.org/obo/HP_0002849	Absence of lymph node germinal center	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		Absence of germinal centers in lymph nodes. Germinal centers are the parts of lymph nodes in which B lymphocytes proliferate, differentiate, mutate through somatic hypermutation and class switch during antibody responses.
http://purl.obolibrary.org/obo/HP_0002850	Decreased circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0410243	Abnormal circulating IgM concentration		An abnormally decreased level of immunoglobulin M (IgM) in blood.
http://purl.obolibrary.org/obo/HP_0002851	Increased double-negative T cell number	http://purl.obolibrary.org/obo/HP_0031399	Abnormal double-negative T cell proportion		Abnormal increase of double negative (DN) CD3+CD4-CD8- T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0002853	Increased HLA-DR+ CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0025840	Abnormal HLA-DR+ CD4+ T cell proportion		Abnormal increase of the activated HLA-DR+ CD4+ T cell subpopulation, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0002857	Genu valgum	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		The legs angle inward, such that the knees are close together and the ankles far apart.
http://purl.obolibrary.org/obo/HP_0002858	Meningioma	http://purl.obolibrary.org/obo/HP_0100835	Benign neoplasm of the central nervous system		The presence of a meningioma, i.e., a benign tumor originating from the dura mater or arachnoid mater.
http://purl.obolibrary.org/obo/HP_0002860	Squamous cell carcinoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		The presence of squamous cell carcinoma of the skin.
http://purl.obolibrary.org/obo/HP_0002861	Melanoma	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea).
http://purl.obolibrary.org/obo/HP_0002862	Bladder carcinoma	http://purl.obolibrary.org/obo/HP_0009725	Bladder neoplasm		The presence of a carcinoma of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0002863	Myelodysplasia	http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm		Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.
http://purl.obolibrary.org/obo/HP_0002865	Medullary thyroid carcinoma	http://purl.obolibrary.org/obo/HP_0002890	Thyroid carcinoma		The presence of a medullary carcinoma of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0002866	Hypoplastic iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		Underdevelopment of the ilium ala.
http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology	http://purl.obolibrary.org/obo/HP_0003272	Abnormal hip bone morphology		An abnormality of the ilium, the largest and uppermost bone of the pelvis.
http://purl.obolibrary.org/obo/HP_0002868	Narrow iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		Decreased width of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally).
http://purl.obolibrary.org/obo/HP_0002869	Flared iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		Widening of the ilium ala, that is of the wing of the ilium, combined with external rotation, leading to a flared appearance of the iliac wing.
http://purl.obolibrary.org/obo/HP_0002870	Obstructive sleep apnea	http://purl.obolibrary.org/obo/HP_0010535	Sleep apnea		Obstructive Sleep Apnea is a condition characterized by the obstruction of the airway and pauses in breathing during sleep, which occur multiple times throughout the night. It is related to the relaxation of muscle tone that typically happens during sleep, leading to a partial collapse of the soft tissues in the airway and causing airflow obstruction.
http://purl.obolibrary.org/obo/HP_0002871	Central apnea	http://purl.obolibrary.org/obo/HP_0002104	Apnea		Apnea resulting from depression of the respiratory centers in the medulla oblongata. There is a lack of respiratory effort rather than obstruction of airflow.
http://purl.obolibrary.org/obo/HP_0002872	Apneic episodes precipitated by illness, fatigue, stress	http://purl.obolibrary.org/obo/HP_0002104	Apnea		Recurrent episodes of apnea that are precipitated by factors such as illness, fatigue, or stress.
http://purl.obolibrary.org/obo/HP_0002875	Exertional dyspnea	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		Perceived difficulty to breathe that occurs with exercise or exertion and improves with rest.
http://purl.obolibrary.org/obo/HP_0002876	Episodic tachypnea	http://purl.obolibrary.org/obo/HP_0002789	Tachypnea		Episodes of very rapid breathing.
http://purl.obolibrary.org/obo/HP_0002877	Nocturnal hypoventilation	http://purl.obolibrary.org/obo/HP_0002791	Hypoventilation		An abnormal reduction in alveolar ventilation occurring during sleep. This is characterized by a rise in arterial carbon dioxide.
http://purl.obolibrary.org/obo/HP_0002878	Respiratory failure	http://purl.obolibrary.org/obo/HP_0002093	Respiratory insufficiency		A severe form of respiratory insufficiency characterized by inadequate gas exchange such that the levels of oxygen or carbon dioxide cannot be maintained within normal limits.
http://purl.obolibrary.org/obo/HP_0002879	Anisospondyly	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Abnormally increased variability of the size of the vertebral bodies.
http://purl.obolibrary.org/obo/HP_0002882	Sudden episodic apnea	http://purl.obolibrary.org/obo/HP_0002104	Apnea		Recurrent bouts of sudden, severe apnea that may be life-threatening.
http://purl.obolibrary.org/obo/HP_0002883	Hyperventilation	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Hyperventilation refers to an increased pulmonary ventilation rate that is faster than necessary for the exchange of gases. Hyperventilation can result from increased frequency of breathing, an increased tidal volume, or both, and leads to an excess intake of oxygen and the blowing off of carbon dioxide.
http://purl.obolibrary.org/obo/HP_0002884	Hepatoblastoma	http://purl.obolibrary.org/obo/HP_0002898	Embryonal neoplasm		A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts.
http://purl.obolibrary.org/obo/HP_0002885	Medulloblastoma	http://purl.obolibrary.org/obo/HP_0100836	Malignant neoplasm of the central nervous system		A rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults.
http://purl.obolibrary.org/obo/HP_0002886	Vagal paraganglioma	http://purl.obolibrary.org/obo/HP_0002864	Paraganglioma of head and neck		A tumor that develops in the retrostyloid compartment of the parapharyngeal space, arising from an island of paraganglion tissue derived from the neural crest that is located on the vagus nerve.
http://purl.obolibrary.org/obo/HP_0002888	Ependymoma	http://purl.obolibrary.org/obo/HP_0009733	Glioma		The presence of an ependymoma of the central nervous system.
http://purl.obolibrary.org/obo/HP_0002890	Thyroid carcinoma	http://purl.obolibrary.org/obo/HP_0100031	Neoplasm of the thyroid gland		The presence of a carcinoma of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0002891	Uterine leiomyosarcoma	http://purl.obolibrary.org/obo/HP_0100243	Leiomyosarcoma		The presence of a leiomyosarcoma of the uterus.
http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma	http://purl.obolibrary.org/obo/HP_0011750	Neoplasm of the anterior pituitary		A benign epithelial tumor derived from intrinsic cells of the adenohypophysis (anterior pituitary).
http://purl.obolibrary.org/obo/HP_0002894	Neoplasm of the pancreas	http://purl.obolibrary.org/obo/HP_0034930	Digestive system neoplasm		A tumor (abnormal growth of tissue) of the pancreas.
http://purl.obolibrary.org/obo/HP_0002895	Papillary thyroid carcinoma	http://purl.obolibrary.org/obo/HP_0002890	Thyroid carcinoma		The presence of a papillary adenocarcinoma of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0002896	Neoplasm of the liver	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A tumor (abnormal growth of tissue) of the liver.
http://purl.obolibrary.org/obo/HP_0002897	Parathyroid adenoma	http://purl.obolibrary.org/obo/HP_0100733	Neoplasm of the parathyroid gland		A benign tumor of the parathyroid gland that can cause hyperparathyroidism.
http://purl.obolibrary.org/obo/HP_0002900	Hypokalemia	http://purl.obolibrary.org/obo/HP_0011042	Abnormal circulating potassium concentration		The concentration of potassium(1+) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0002901	Hypocalcemia	http://purl.obolibrary.org/obo/HP_0004363	Abnormal circulating calcium concentration		The concentration of calcium in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0002902	Hyponatremia	http://purl.obolibrary.org/obo/HP_0010931	Abnormal circulating sodium concentration		The concentration of sodium in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0002904	Hyperbilirubinemia	http://purl.obolibrary.org/obo/HP_0033479	Abnormal circulating bilirubin concentration		An increased amount of bilirubin in the blood.
http://purl.obolibrary.org/obo/HP_0002905	Hyperphosphatemia	http://purl.obolibrary.org/obo/HP_0100529	Abnormal circulating phosphate ion concentration		The concentration of phosphate ion in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0002907	Microscopic hematuria	http://purl.obolibrary.org/obo/HP_0000790	Hematuria		Microscopic hematuria detected by dipstick or microscopic examination of the urine.
http://purl.obolibrary.org/obo/HP_0002909	Generalized aminoaciduria	http://purl.obolibrary.org/obo/HP_0003355	Aminoaciduria		An increased concentration of all types of amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0002910	Elevated circulating hepatic transaminase concentration	http://purl.obolibrary.org/obo/HP_0430135	Abnormal circulating hepatic transaminase concentration		Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage.
http://purl.obolibrary.org/obo/HP_0002913	Myoglobinuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Presence of myoglobin in the urine.
http://purl.obolibrary.org/obo/HP_0002914	Hyperchloriduria	http://purl.obolibrary.org/obo/HP_0012600	Abnormal urine chloride concentration		An increased concentration of chloride in the urine.
http://purl.obolibrary.org/obo/HP_0002916	Abnormality of chromosome segregation	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An abnormality of chromosome segregation.
http://purl.obolibrary.org/obo/HP_0002917	Hypomagnesemia	http://purl.obolibrary.org/obo/HP_0004921	Abnormal circulating magnesium concentration		The concentration of magnesium in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0002918	Hypermagnesemia	http://purl.obolibrary.org/obo/HP_0004921	Abnormal circulating magnesium concentration		The concentration of magnesium in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0002919	Ketonuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		High levels of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the urine. Ketone bodies are insignificant in the blood and urine of normal individuals in the postprandial or overnight-fasted state.
http://purl.obolibrary.org/obo/HP_0002920	Decreased circulating ACTH concentration	http://purl.obolibrary.org/obo/HP_0011043	Abnormal circulating adrenocorticotropin concentration		The concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), is below the lower limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		An abnormality of the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0002922	Increased CSF protein concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Increased concentration of protein in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0002923	Rheumatoid factor positive	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence in the serum of an autoantibody directed against the Fc portion of IgG.
http://purl.obolibrary.org/obo/HP_0002925	Elevated circulating thyroid-stimulating hormone concentration	http://purl.obolibrary.org/obo/HP_0031097	Abnormal circulating thyroid-stimulating hormone concentration		Increased concentration of thyroid-stimulating hormone (TSH) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology	http://purl.obolibrary.org/obo/HP_0000820	Abnormality of the thyroid gland		An abnormal functionality of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0002927	Histidinuria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An increased concentration of histidine in the urine.
http://purl.obolibrary.org/obo/HP_0002930	Impaired sensitivity to thyroid hormone	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		Reduced sensitivity of end organs to thyroid hormone characterized by elevated serum levels of free thyroid hormone with nonsuppressed thyroid stimulating hormone.
http://purl.obolibrary.org/obo/HP_0002932	Aldehyde oxidase deficiency	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		A reduction in aldehyde oxidase level.
http://purl.obolibrary.org/obo/HP_0002933	Ventral hernia	http://purl.obolibrary.org/obo/HP_0004299	Hernia of the abdominal wall		Ventral hernia refers to a condition in which abdominal contents protrude through a weakened portion of the abdominal wall.
http://purl.obolibrary.org/obo/HP_0002936	Distal sensory impairment	http://purl.obolibrary.org/obo/HP_0003474	Somatic sensory dysfunction		An abnormal reduction in sensation in the distal portions of the extremities.
http://purl.obolibrary.org/obo/HP_0002937	Hemivertebrae	http://purl.obolibrary.org/obo/HP_0003422	Vertebral segmentation defect		Absence of one half of the vertebral body.
http://purl.obolibrary.org/obo/HP_0002938	Lumbar hyperlordosis	http://purl.obolibrary.org/obo/HP_0003307	Hyperlordosis		An abnormal accentuation of the inward curvature of the spine in the lumbar region.
http://purl.obolibrary.org/obo/HP_0002942	Thoracic kyphosis	http://purl.obolibrary.org/obo/HP_0100711	Abnormal thoracic spine morphology		Over curvature of the thoracic region, leading to a round back or if sever to a hump.
http://purl.obolibrary.org/obo/HP_0002945	Intervertebral space narrowing	http://purl.obolibrary.org/obo/HP_0005108	Abnormal intervertebral disk morphology		Decreased height of the intervertebral disk.
http://purl.obolibrary.org/obo/HP_0002947	Cervical kyphosis	http://purl.obolibrary.org/obo/HP_0005905	Abnormal cervical curvature		Exaggerated convexity of the cervical vertebral column, causing the cervical spine to bow outwards and take on a rounded appearance.
http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion	http://purl.obolibrary.org/obo/HP_0100240	Synostosis of joints		A developmental defect leading to the union of two adjacent vertebrae.
http://purl.obolibrary.org/obo/HP_0002949	Fused cervical vertebrae	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		A congenital anomaly characterized by a joining (fusion) of two or more cervical vertebral bodies with one another.
http://purl.obolibrary.org/obo/HP_0002951	Partial absence of cerebellar vermis	http://purl.obolibrary.org/obo/HP_0006817	Aplasia/Hypoplasia of the cerebellar vermis		Congenital absence of a part of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis	http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology		A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.
http://purl.obolibrary.org/obo/HP_0002958	Immune dysregulation	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		Altered immune function characterized by lymphoid proliferation, immune activation, and excessive autoreactivity often leading to autoimmune/inflammatory complications.
http://purl.obolibrary.org/obo/HP_0002959	Impaired Ig class switch recombination	http://purl.obolibrary.org/obo/HP_0005372	Abnormal B cell physiology		An impairment of the class-switch recombination process that normally leads B lymphocytes to produce IgG, IgA, or IgE.
http://purl.obolibrary.org/obo/HP_0002963	Abnormal delayed hypersensitivity skin test	http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology		Delay in cutaneous immune reaction to specific antigens mediated not by antibodies but by cells. The delayed hypersensitivity test is an immune function test measuring the presence of activated T cells that recognize a specific antigen and is performed by injecting a small amount of the antigen into the skin. The area of the injection is examined 48-72 hours thereafter.
http://purl.obolibrary.org/obo/HP_0002965	Cutaneous anergy	http://purl.obolibrary.org/obo/HP_0002963	Abnormal delayed hypersensitivity skin test		Inability to react to a delayed hypersensitivity skin test.
http://purl.obolibrary.org/obo/HP_0002967	Cubitus valgus	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		Abnormal positioning in which the elbows are turned out.
http://purl.obolibrary.org/obo/HP_0002971	Absent microvilli on the surface of peripheral blood lymphocytes	http://purl.obolibrary.org/obo/HP_0004332	Abnormal lymphocyte morphology		Absence of the fingerlike protrusive, actin-dependent structures found on the surface of peripheral blood lymphocytes.
http://purl.obolibrary.org/obo/HP_0002972	Reduced delayed hypersensitivity	http://purl.obolibrary.org/obo/HP_0002963	Abnormal delayed hypersensitivity skin test		Decreased ability to react to a delayed hypersensitivity skin test.
http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		An abnormality of the lower arm.
http://purl.obolibrary.org/obo/HP_0002974	Radioulnar synostosis	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		An abnormal osseous union (fusion) between the radius and the ulna.
http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		Absence or underdevelopment of tissue in the central nervous system.
http://purl.obolibrary.org/obo/HP_0002979	Bowing of the legs	http://purl.obolibrary.org/obo/HP_0006487	Bowing of the long bones		A bending or abnormal curvature affecting a long bone of the leg.
http://purl.obolibrary.org/obo/HP_0002980	Femoral bowing	http://purl.obolibrary.org/obo/HP_0002979	Bowing of the legs		Bowing (abnormal curvature) of the femur.
http://purl.obolibrary.org/obo/HP_0002981	Abnormality of the calf	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		An abnormality of the calf, i.e. of the posterior part of the lower leg.
http://purl.obolibrary.org/obo/HP_0002982	Tibial bowing	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		A bending or abnormal curvature of the tibia.
http://purl.obolibrary.org/obo/HP_0002984	Hypoplasia of the radius	http://purl.obolibrary.org/obo/HP_0009821	Forearm undergrowth		Underdevelopment of the radius.
http://purl.obolibrary.org/obo/HP_0002986	Radial bowing	http://purl.obolibrary.org/obo/HP_0045008	Abnormal shape of the radius		A bending or abnormal curvature of the radius.
http://purl.obolibrary.org/obo/HP_0002987	Elbow flexion contracture	http://purl.obolibrary.org/obo/HP_0034391	Elbow contracture		An elbow contracture that limits the ability of the elbow joint to be extended (straightened), meaning that the elbow is fixed in an flexed (bent) position.
http://purl.obolibrary.org/obo/HP_0002990	Fibular aplasia	http://purl.obolibrary.org/obo/HP_0006492	Aplasia/Hypoplasia of the fibula		Absence of the fibula.
http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		An anomaly of the calf bone (fibula), one of the two bones of the calf.
http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		Abnormality of the tibia (shinbone).
http://purl.obolibrary.org/obo/HP_0002999	Patellar dislocation	http://purl.obolibrary.org/obo/HP_0030311	Lower extremity joint dislocation		The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar dislocation occurs if the patella fully dislocates out of the groove.
http://purl.obolibrary.org/obo/HP_0003002	Breast carcinoma	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		The presence of a carcinoma of the breast.
http://purl.obolibrary.org/obo/HP_0003005	Ganglioneuroma	http://purl.obolibrary.org/obo/HP_0030450	Neoplasm of the autonomic nervous system		A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum, representing a tumor of the sympathetic nerve fibers arising from neural crest cells.
http://purl.obolibrary.org/obo/HP_0003006	Neuroblastoma	http://purl.obolibrary.org/obo/HP_0030067	Peripheral primitive neuroectodermal neoplasm		Neuroblastoma is a solid tumor that originate in neural crest cells of the sympathetic nervous system. Most neuroblastomas originate in the abdomen, and most abdominal neuroblastomas originate in the adrenal gland. Neuroblastomas can also originate in the thorax, usually in the posterior mediastinum.
http://purl.obolibrary.org/obo/HP_0003010	Prolonged bleeding time	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding.
http://purl.obolibrary.org/obo/HP_0003011	Abnormality of the musculature	http://purl.obolibrary.org/obo/HP_0033127	Abnormality of the musculoskeletal system		Abnormality originating in one or more muscles, i.e., of the set of muscles of body.
http://purl.obolibrary.org/obo/HP_0003013	Bulging epiphyses	http://purl.obolibrary.org/obo/HP_0010580	Enlarged epiphyses		A morphological abnormality of epiphyses whereby they are abnormally outwardly curving (protuberant).
http://purl.obolibrary.org/obo/HP_0003015	Flared metaphysis	http://purl.obolibrary.org/obo/HP_0003016	Metaphyseal widening		The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones.
http://purl.obolibrary.org/obo/HP_0003016	Metaphyseal widening	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Abnormal widening of the metaphyseal regions of long bones.
http://purl.obolibrary.org/obo/HP_0003019	Abnormality of the wrist	http://purl.obolibrary.org/obo/HP_0009810	Abnormality of upper limb joint		Abnormality of the wrist, the structure connecting the hand and the forearm.
http://purl.obolibrary.org/obo/HP_0003021	Metaphyseal cupping	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Metaphyseal cupping refers to an inward bulging of the metaphyseal profile giving the metaphysis a cup-like appearance.
http://purl.obolibrary.org/obo/HP_0003022	Hypoplasia of the ulna	http://purl.obolibrary.org/obo/HP_0009821	Forearm undergrowth		Underdevelopment of the ulna.
http://purl.obolibrary.org/obo/HP_0003023	Bowing of limbs due to multiple fractures	http://purl.obolibrary.org/obo/HP_0002659	Increased susceptibility to fractures		Curvature of the shafts of the long bones due to multiple fractures.
http://purl.obolibrary.org/obo/HP_0003025	Metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Irregularity of the normally smooth surface of the metaphyses.
http://purl.obolibrary.org/obo/HP_0003026	Short long bone	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		One or more abnormally short long bone.
http://purl.obolibrary.org/obo/HP_0003028	Abnormality of the ankle	http://purl.obolibrary.org/obo/HP_0100491	Abnormality of lower limb joint		An anomaly of the joint that connects the foot with the leg.
http://purl.obolibrary.org/obo/HP_0003031	Ulnar bowing	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Bending of the diaphysis (shaft) of the ulna.
http://purl.obolibrary.org/obo/HP_0003034	Diaphyseal sclerosis	http://purl.obolibrary.org/obo/HP_0006392	Increased density of long bones		An elevation in bone density in one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0003037	Enlarged joints	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		Increase in size of one or more joints.
http://purl.obolibrary.org/obo/HP_0003038	Fibular hypoplasia	http://purl.obolibrary.org/obo/HP_0006492	Aplasia/Hypoplasia of the fibula		Underdevelopment of the fibula.
http://purl.obolibrary.org/obo/HP_0003041	Humeroradial synostosis	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		An abnormal osseous union (fusion) between the radius and the humerus.
http://purl.obolibrary.org/obo/HP_0003042	Elbow dislocation	http://purl.obolibrary.org/obo/HP_0030310	Upper extremity joint dislocation		Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet.
http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology	http://purl.obolibrary.org/obo/HP_0011844	Abnormal appendicular skeleton morphology		An abnormality of the shoulder, which is defined as the structures surrounding the shoulder joint where the humerus attaches to the scapula.
http://purl.obolibrary.org/obo/HP_0003044	Shoulder flexion contracture	http://purl.obolibrary.org/obo/HP_0034665	Shoulder contracture		Chronic reduction in active and passive mobility of the shoulder joint due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.
http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		Abnormality of the patella (knee cap).
http://purl.obolibrary.org/obo/HP_0003048	Radial head subluxation	http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation		Partial dislocation of the head of the radius.
http://purl.obolibrary.org/obo/HP_0003051	Enlarged metaphyses	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Abnormal increase in size of one or more metaphyses.
http://purl.obolibrary.org/obo/HP_0003057	Tetraamelia	http://purl.obolibrary.org/obo/HP_0009827	Amelia		Amelia of all four limbs.
http://purl.obolibrary.org/obo/HP_0003065	Patellar hypoplasia	http://purl.obolibrary.org/obo/HP_0006498	Aplasia/Hypoplasia of the patella		Underdevelopment of the patella.
http://purl.obolibrary.org/obo/HP_0003066	Limited knee extension	http://purl.obolibrary.org/obo/HP_0010501	Limitation of knee mobility		Reduced ability to extend (straighten) the knee joint.
http://purl.obolibrary.org/obo/HP_0003067	Madelung deformity	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		An anomaly related to partial closure, or failure of development of the ulnar side of the distal radial growth plate, which results in an arrest of epiphyseal growth of the medial and volar portions of the distal radius. This leads to shortening of the radius and relative overgrowth of the ulna.
http://purl.obolibrary.org/obo/HP_0003071	Flattened epiphysis	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Abnormal flatness (decreased height) of epiphyses.
http://purl.obolibrary.org/obo/HP_0003072	Hypercalcemia	http://purl.obolibrary.org/obo/HP_0004363	Abnormal circulating calcium concentration		The concentration of calcium in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003073	Hypoalbuminemia	http://purl.obolibrary.org/obo/HP_0012116	Abnormal circulating albumin concentration		The concentration of albumin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0003074	Hyperglycemia	http://purl.obolibrary.org/obo/HP_0011015	Abnormal blood glucose concentration		An increased concentration of glucose in the blood.
http://purl.obolibrary.org/obo/HP_0003075	Hypoproteinemia	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		A decreased concentration of protein in the blood.
http://purl.obolibrary.org/obo/HP_0003076	Glycosuria	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		An increased concentration of glucose in the urine.
http://purl.obolibrary.org/obo/HP_0003077	Hyperlipidemia	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		An elevated lipid concentration in the blood.
http://purl.obolibrary.org/obo/HP_0003080	Hydroxyprolinuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		An increased concentration of 4-hydroxy-L-proline in the urine.
http://purl.obolibrary.org/obo/HP_0003081	Increased urinary potassium	http://purl.obolibrary.org/obo/HP_0012598	Abnormal urine potassium concentration		An increased concentration of potassium(1+) in the urine.
http://purl.obolibrary.org/obo/HP_0003083	Dislocated radial head	http://purl.obolibrary.org/obo/HP_0100744	Abnormality of the humeroradial joint		A dislocation of the head of the radius from its socket in the elbow joint.
http://purl.obolibrary.org/obo/HP_0003084	Recurrent long bone fractures	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		An increased tendency to fractures of the long bones (Mainly, the femur, tibia, fibula, humerus, radius, and ulna).
http://purl.obolibrary.org/obo/HP_0003085	Long fibula	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		Disproportionately long fibulae.
http://purl.obolibrary.org/obo/HP_0003086	Acromesomelia	http://purl.obolibrary.org/obo/HP_0003027	Mesomelia		Small hands and feet.
http://purl.obolibrary.org/obo/HP_0003090	Hypoplasia of the capital femoral epiphysis	http://purl.obolibrary.org/obo/HP_0005003	Aplasia/Hypoplasia of the capital femoral epiphysis		Underdevelopment of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0003091	Trophic limb changes	http://purl.obolibrary.org/obo/HP_0010834	Trophic changes related to pain		Trophic changes occurring in a limb.
http://purl.obolibrary.org/obo/HP_0003093	Limited hip extension	http://purl.obolibrary.org/obo/HP_0008800	Limited hip movement		Limitation of the extension of the hip, i.e., decreased ability to straighten the hip joint and thereby increase the angle between torso and thigh; moving the thigh or top of the pelvis backward.
http://purl.obolibrary.org/obo/HP_0003097	Short femur	http://purl.obolibrary.org/obo/HP_0005613	Aplasia/hypoplasia of the femur		An abnormal shortening of the femur.
http://purl.obolibrary.org/obo/HP_0003099	Fibular overgrowth	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		Relatively increased growth of the fibula compared to that of the tibia.
http://purl.obolibrary.org/obo/HP_0003100	Slender long bone	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		Reduced diameter of a long bone.
http://purl.obolibrary.org/obo/HP_0003102	Increased carrying angle	http://purl.obolibrary.org/obo/HP_0020301	Abnormal elbow physiology		An abnormal increase in the carrying angle, which is the angle he long axis of the extended forearm as it lies lateral to the long axis of the arm.
http://purl.obolibrary.org/obo/HP_0003103	Abnormal cortical bone morphology	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		An abnormality of compact bone (also known as cortical bone), which forms the dense surface of bones.
http://purl.obolibrary.org/obo/HP_0003105	Protuberances at ends of long bones	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		The presence of multiple protuberances (bulges, or knobs) at the ends of the long bones.
http://purl.obolibrary.org/obo/HP_0003106	Subperiosteal bone resorption	http://purl.obolibrary.org/obo/HP_0002813	Abnormal limb bone morphology		Loss of bone mass occurring beneath the periosteum (the periosteum is the connective-tissue membrane that surrounds all bones except at the articular surfaces). This process may create a serrated and lace-like appearance in periosteal cortical bone.
http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		Any deviation from the normal concentration of cholesterol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0003108	Hyperglycinuria	http://purl.obolibrary.org/obo/HP_0033099	Increased serine family amino acid in urine		An increased concentration of glycine in the urine.
http://purl.obolibrary.org/obo/HP_0003109	Hyperphosphaturia	http://purl.obolibrary.org/obo/HP_0012599	Abnormal urine phosphate concentration		An increased excretion of phosphates in the urine.
http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis	http://purl.obolibrary.org/obo/HP_0011277	Abnormality of the urinary system physiology		An abnormality of the composition of urine or the levels of its components.
http://purl.obolibrary.org/obo/HP_0003111	Abnormal circulating electrolyte concentration	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Abnormality of the homeostasis (concentration) of a monoatomic ion.
http://purl.obolibrary.org/obo/HP_0003112	Abnormal circulating amino acid concentration	http://purl.obolibrary.org/obo/HP_0033405	Abnormal circulating organic amino compound concentration		Any deviation from the normal concentration of amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0003113	Hypochloremia	http://purl.obolibrary.org/obo/HP_0011422	Abnormal circulating chloride concentration		The concentration of chloride in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG	http://purl.obolibrary.org/obo/HP_0030956	Abnormality of cardiovascular system electrophysiology		Abnormal rhythm of the heart.
http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		Concentration of a hormone in the blood circulation outside of normal limits.
http://purl.obolibrary.org/obo/HP_0003118	Increased circulating cortisol level	http://purl.obolibrary.org/obo/HP_0011731	Abnormality of circulating cortisol level		Overproduction of the hormone of cortisol by the adrenal cortex, resulting in a characteristic combination of clinical symptoms termed Cushing syndrome, with truncal obesity, a round, full face, striae atrophicae and acne, muscle weakness, and other features.
http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		Any deviation from the normal concentration of a lipid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0003121	Limb joint contracture	http://purl.obolibrary.org/obo/HP_0034392	Joint contracture		A contracture (chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin) that prevent normal movement of one or more joints of the limbs.
http://purl.obolibrary.org/obo/HP_0003124	Hypercholesterolemia	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		An increased concentration of cholesterol in the blood.
http://purl.obolibrary.org/obo/HP_0003126	Low-molecular-weight proteinuria	http://purl.obolibrary.org/obo/HP_0000093	Proteinuria		Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD).
http://purl.obolibrary.org/obo/HP_0003127	Hypocalciuria	http://purl.obolibrary.org/obo/HP_0011280	Abnormality of urine calcium concentration		An abnormally decreased calcium concentration in the urine.
http://purl.obolibrary.org/obo/HP_0003128	Lactic acidosis	http://purl.obolibrary.org/obo/HP_0001941	Acidosis		An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids.
http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination	http://purl.obolibrary.org/obo/HP_0012447	Abnormal myelination		An abnormality of the myelination of motor and sensory peripheral nerves. These are axons for motor nerves and dendrites for sensory nerves in the strict anatomic sense.
http://purl.obolibrary.org/obo/HP_0003131	Cystinuria	http://purl.obolibrary.org/obo/HP_0033095	Increased sulfur amino acid level in urine		An increased concentration of cystine in the urine.
http://purl.obolibrary.org/obo/HP_0003133	Abnormal spinocerebellar tract morphology	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		An abnormality of the spinocerebellar tracts, a set of axonal fibers originating in the spinal cord and terminating in the ipsilateral cerebellum. The spinocerebellar tract convey information to the cerebellum about limb and joint position (proprioception). They comprise the ventral spinocerebellar tract, the anterior spinocerebellar tract, and the posterior spinocerebellar tract.
http://purl.obolibrary.org/obo/HP_0003134	Abnormality of peripheral nerve conduction	http://purl.obolibrary.org/obo/HP_0030177	Abnormality of peripheral nervous system electrophysiology		An abnormality of the conduction of electrical impulses by peripheral (motor or sensory) nerves. This finding is elicited by a nerve conduction study (NCS).
http://purl.obolibrary.org/obo/HP_0003137	Prolinuria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		Level of proline in the urine anove the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003138	Increased blood urea nitrogen	http://purl.obolibrary.org/obo/HP_0031970	Abnormal blood urea nitrogen concentration		An increased amount of nitrogen in the form of urea in the blood.
http://purl.obolibrary.org/obo/HP_0003139	Panhypogammaglobulinemia	http://purl.obolibrary.org/obo/HP_0004313	Decreased circulating immunoglobulin concentration		A reduction in the circulating levels of all the major classes of immunoglobulin. is characterized by profound decreases in all classes of immunoglobulin with an absence of circulating B lymphocytes.
http://purl.obolibrary.org/obo/HP_0003141	Elevated circulating LDL-C concentration	http://purl.obolibrary.org/obo/HP_0031886	Abnormal LDL cholesterol concentration		The concentration of low-density lipoprotein cholesterol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003144	Increased serum serotonin	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		A increased concentration of serotonin in the blood.
http://purl.obolibrary.org/obo/HP_0003145	Decreased circulating adenosylcobalamin concentration	http://purl.obolibrary.org/obo/HP_0004341	Abnormal vitamin B12 concentration		The concentration of adenosylcobalam in the blood circulation is below the lower limit of normal. Adenosylcobalamin is one of the active forms of vitamin B12.
http://purl.obolibrary.org/obo/HP_0003146	Hypocholesterolemia	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		An decreased concentration of cholesterol in the blood.
http://purl.obolibrary.org/obo/HP_0003149	Hyperuricosuria	http://purl.obolibrary.org/obo/HP_0012610	Abnormality of urinary uric acid level		An abnormally high level of uric acid in the urine.
http://purl.obolibrary.org/obo/HP_0003150	Glutaric aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of glutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003153	Cystathioninuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		An elevated urinary concentration of cystathionine.
http://purl.obolibrary.org/obo/HP_0003154	Increased circulating ACTH level	http://purl.obolibrary.org/obo/HP_0011043	Abnormal circulating adrenocorticotropin concentration		An abnormal increased in the concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), in the blood.
http://purl.obolibrary.org/obo/HP_0003155	Elevated circulating alkaline phosphatase concentration	http://purl.obolibrary.org/obo/HP_0004379	Abnormality of alkaline phosphatase level		Abnormally increased serum levels of alkaline phosphatase activity.
http://purl.obolibrary.org/obo/HP_0003158	Hyposthenuria	http://purl.obolibrary.org/obo/HP_0033358	Abnormal urine osmolality		An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine.
http://purl.obolibrary.org/obo/HP_0003159	Hyperoxaluria	http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria		Increased excretion of oxalates in the urine.
http://purl.obolibrary.org/obo/HP_0003160	Abnormal isoelectric focusing of serum transferrin	http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation		Glycosylated transferrin concentrations can be measured in serum as a marker of N-linked glycosylation fidelity. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II. These terms are retained for historical reasons but for new annotations the precise glycosylation defect should be recorded.
http://purl.obolibrary.org/obo/HP_0003161	4-Hydroxyphenylpyruvic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Increased relative concentration of 4-hydroxyphenylpyruvic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003163	Elevated urinary delta-aminolevulinic acid	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		An increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine.
http://purl.obolibrary.org/obo/HP_0003164	Gonadotropin-releasing hormone deficiency	http://purl.obolibrary.org/obo/HP_0500012	Abnormal gonadotropin-releasing hormone concentration		Gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids (primarily testosterone or estradiol). GnRH is not typically assayed directly because it is released in pulses from the hypothalamus, and its concentration can fluctuate rapidly and in a complex pattern that makes single blood measurements less informative than the pituitary's response.
http://purl.obolibrary.org/obo/HP_0003165	Elevated circulating parathyroid hormone level	http://purl.obolibrary.org/obo/HP_0100530	Abnormal circulating calcium-phosphate regulating hormone concentration		An abnormal increased concentration of parathyroid hormone.
http://purl.obolibrary.org/obo/HP_0003166	Increased urinary taurine	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		Increased concentration of taurine in the urine.
http://purl.obolibrary.org/obo/HP_0003167	Carnosinuria	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		An increased concentration of carnosine in the urine.
http://purl.obolibrary.org/obo/HP_0003168	Dibasicaminoaciduria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An increased level of a dibasic amino acid in the urine. Dibasic amino acids are usually referred to simply as basic aminoacids because they contain basic side chains at neutral pH. These are arginine (Arg), lysine (Lys), and histidine (His).
http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology	http://purl.obolibrary.org/obo/HP_0001384	Abnormal hip joint morphology		An abnormality of the acetabulum, i.e., the Acetabular part of hip bone, which together with the head of the femur forms the hip joint.
http://purl.obolibrary.org/obo/HP_0003172	Abnormal pubic bone morphology	http://purl.obolibrary.org/obo/HP_0003272	Abnormal hip bone morphology		An anomaly of the the pubic bone, i.e., of the ventral and anterior of the three principal components (pubis, ilium, ischium) of the hip bone.
http://purl.obolibrary.org/obo/HP_0003173	Hypoplastic pubic bone	http://purl.obolibrary.org/obo/HP_0009104	Aplasia/Hypoplasia of the pubic bone		Underdevelopment of the pubis, which together with the ilium and the ischium, is one of the three bones that make up the hip bone.
http://purl.obolibrary.org/obo/HP_0003174	Abnormal ischium morphology	http://purl.obolibrary.org/obo/HP_0003272	Abnormal hip bone morphology		An anomaly of the ischium, which forms the lower and back part of the hip bone.
http://purl.obolibrary.org/obo/HP_0003175	Hypoplastic ischia	http://purl.obolibrary.org/obo/HP_0003174	Abnormal ischium morphology		Underdevelopment of the ischium, which forms the lower and back part of the hip bone.
http://purl.obolibrary.org/obo/HP_0003177	Squared iliac bones	http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology		A shift from the normally round (convex) appearance of the iliac wing towards a square-like appearance.
http://purl.obolibrary.org/obo/HP_0003179	Protrusio acetabuli	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		Intrapelvic bulging of the medial acetabular wall.
http://purl.obolibrary.org/obo/HP_0003180	Flat acetabular roof	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		Flattening of the superior part of the acetabulum, which is a cup-shaped cavity at the base of the hipbone into which the ball-shaped head of the femur fits. The acetabular roof thereby appears horizontal rather than arched, as it normally does.
http://purl.obolibrary.org/obo/HP_0003183	Wide pubic symphysis	http://purl.obolibrary.org/obo/HP_0003172	Abnormal pubic bone morphology		Abnormally increased width of the pubic symphysis is the midline cartilaginous joint uniting the superior rami of the left and right pubic bones.
http://purl.obolibrary.org/obo/HP_0003184	Decreased hip abduction	http://purl.obolibrary.org/obo/HP_0008800	Limited hip movement		Reduced ability to move the femur outward to the side.
http://purl.obolibrary.org/obo/HP_0003185	Short greater sciatic notch	http://purl.obolibrary.org/obo/HP_0010456	Abnormal greater sciatic notch morphology		The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a reduction in the height of the notch.
http://purl.obolibrary.org/obo/HP_0003186	Inverted nipples	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		The presence of nipples that instead of pointing outward are retracted inwards.
http://purl.obolibrary.org/obo/HP_0003189	Long nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Distance from nasion to subnasale more than two standard deviations above the mean, or alternatively, an apparently increased length from the nasal root to the nasal base.
http://purl.obolibrary.org/obo/HP_0003191	Cleft ala nasi	http://purl.obolibrary.org/obo/HP_0000429	Abnormal morphology of the nasal alae		The presence of a notch in the margin of the ala nasi.
http://purl.obolibrary.org/obo/HP_0003193	Allergic rhinitis	http://purl.obolibrary.org/obo/HP_0012393	Allergy		It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea.
http://purl.obolibrary.org/obo/HP_0003194	Short nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		Decreased superior-inferior length of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose.
http://purl.obolibrary.org/obo/HP_0003196	Short nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Distance from nasion to subnasale more than two standard deviations below the mean, or alternatively, an apparently decreased length from the nasal root to the nasal tip.
http://purl.obolibrary.org/obo/HP_0003198	Myopathy	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.
http://purl.obolibrary.org/obo/HP_0003200	Ragged-red muscle fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		An abnormal appearance of muscle fibers observed on muscle biopsy. Ragged red fibers can be visualized with Gomori trichrome staining as irregular and intensely red subsarcolemmal zones, whereas the normal myofibrils are green. The margins of affect fibers appear red and ragged. The ragged-red is due to the accumulation of abnormal mitochondria below the plasma membrane of the muscle fiber, leading to the appearance of a red rim and speckled sarcoplasm.
http://purl.obolibrary.org/obo/HP_0003201	Rhabdomyolysis	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream.
http://purl.obolibrary.org/obo/HP_0003203	Decreased neutrophil oxidative burst	http://purl.obolibrary.org/obo/HP_0011990	Abnormal neutrophil physiology		Abnormal decrease of neutrophil oxidative burst, commonly measured through oxidation of dihydrorhodamine (DHR) using flow cytometry or through nitroblue tetrazolium test (NBT) using optical microscopy, upon stimulation with phorbol-12-myristate-13-acetate (PMA), E. coli or other ligands.
http://purl.obolibrary.org/obo/HP_0003204	Intracellular accumulation of autofluorescent lipopigment storage material	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		The intracellular accumulation of autofluorescent storage material.
http://purl.obolibrary.org/obo/HP_0003205	Curvilinear intracellular accumulation of autofluorescent lipopigment storage material	http://purl.obolibrary.org/obo/HP_0003204	Intracellular accumulation of autofluorescent lipopigment storage material		An intracellular accumulation of autofluorescent lipopigment storage material in a curved pattern.
http://purl.obolibrary.org/obo/HP_0003207	Arterial calcification	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Pathological deposition of calcium salts in one or more arteries.
http://purl.obolibrary.org/obo/HP_0003208	Fingerprint intracellular accumulation of autofluorescent lipopigment storage material	http://purl.obolibrary.org/obo/HP_0003204	Intracellular accumulation of autofluorescent lipopigment storage material		An intracellular accumulation of autofluorescent lipopigment storage material in a trabecular or fingerprint-like pattern.
http://purl.obolibrary.org/obo/HP_0003209	Decreased pyruvate carboxylase activity	http://purl.obolibrary.org/obo/HP_0000816	Abnormality of Krebs cycle metabolism		A decreased rate of pyruvate carboxylase activity.
http://purl.obolibrary.org/obo/HP_0003210	Decreased methylmalonyl-CoA mutase activity	http://purl.obolibrary.org/obo/HP_0000816	Abnormality of Krebs cycle metabolism		An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of methylmalonyl-CoA mutase activity.
http://purl.obolibrary.org/obo/HP_0003212	Increased circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0410241	Abnormal circulating IgE concentration		An abnormally increased overall level of immunoglobulin E in blood.
http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An increased concentration of dicarboxylic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003216	Generalized amyloid deposition	http://purl.obolibrary.org/obo/HP_0020015	Amyloid deposition by anatomical site		A diffuse form of amyloidosis.
http://purl.obolibrary.org/obo/HP_0003217	Hyperglutaminemia	http://purl.obolibrary.org/obo/HP_0010903	Abnormal circulating glutamine concentration		The concentration of glutamine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003218	Oroticaciduria	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		An increased concentration of orotic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003219	Ethylmalonic aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of ethylmalonic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003220	Abnormality of chromosome stability	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		A type of chromosomal aberration characterized by reduced resistance of chromosomes to change or deterioration.
http://purl.obolibrary.org/obo/HP_0003221	Chromosomal breakage induced by crosslinking agents	http://purl.obolibrary.org/obo/HP_0040012	Chromosome breakage		Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with DNA cross-linking agents such as diepoxybutane and mitomycin C.
http://purl.obolibrary.org/obo/HP_0003223	Decreased circulating methylcobalamin concentration	http://purl.obolibrary.org/obo/HP_0003145	Decreased circulating adenosylcobalamin concentration		The concentration of methylcobalamin in the blood circulation is below the lower limit of normal. Methylcobalamin is a form of vitamin B12.
http://purl.obolibrary.org/obo/HP_0003225	Reduced coagulation factor V activity	http://purl.obolibrary.org/obo/HP_0031899	Abnormal coagulation factor V activity		Decreased activity of coagulation factor V.
http://purl.obolibrary.org/obo/HP_0003226	Rectilinear intracellular accumulation of autofluorescent lipopigment storage material	http://purl.obolibrary.org/obo/HP_0003204	Intracellular accumulation of autofluorescent lipopigment storage material		An intracellular accumulation of autofluorescent lipopigment storage material in a straight or rectilinear pattern.
http://purl.obolibrary.org/obo/HP_0003228	Hypernatremia	http://purl.obolibrary.org/obo/HP_0010931	Abnormal circulating sodium concentration		The concentration of sodium in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003233	Decreased circulating HDL-C concentration	http://purl.obolibrary.org/obo/HP_0031888	Abnormal circulating HDL-C concentration		The concentration of high-density lipoprotein cholesterol in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0003234	Decreased circulating carnitine concentration	http://purl.obolibrary.org/obo/HP_0010967	Abnormal circulating carnitine concentration		Concentration of carnitine in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0003235	Hypermethioninemia	http://purl.obolibrary.org/obo/HP_0010901	Abnormal circulating methionine concentration		An increased concentration of methionine in the blood.
http://purl.obolibrary.org/obo/HP_0003236	Elevated circulating creatine kinase activity	http://purl.obolibrary.org/obo/HP_0040081	Abnormal circulating creatine kinase activity		The activity of creatine kinase in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003237	Increased circulating IgG concentration	http://purl.obolibrary.org/obo/HP_0410242	Abnormal circulating IgG concentration		An abnormally increased level of immunoglobulin G in blood.
http://purl.obolibrary.org/obo/HP_0003238	Hyperpepsinogenemia I	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of pepsinogen I in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003239	Phosphoethanolaminuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An increased level of phosphoethanolamine (synonym: O-phosphoethanolamine) in the urine.
http://purl.obolibrary.org/obo/HP_0003240	Increased phosphoribosylpyrophosphate synthetase level	http://purl.obolibrary.org/obo/HP_0032459	Abnormal phosphoribosylpyrophosphate synthetase level		Abnormally elevated level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.
http://purl.obolibrary.org/obo/HP_0003241	External genital hypoplasia	http://purl.obolibrary.org/obo/HP_0000811	Abnormal external genitalia morphology		Underdevelopment of part or all of the external reproductive organs.
http://purl.obolibrary.org/obo/HP_0003244	Penile hypospadias	http://purl.obolibrary.org/obo/HP_0000047	Hypospadias		Location of the urethral opening on the inferior aspect of the penis.
http://purl.obolibrary.org/obo/HP_0003246	Prominent scrotal raphe	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Increased size of the ridge of tissue that extends along the midline of the scrotum.
http://purl.obolibrary.org/obo/HP_0003250	Aplasia of the vagina	http://purl.obolibrary.org/obo/HP_0011026	Aplasia/Hypoplasia of the vagina		Aplasia of the vagina.
http://purl.obolibrary.org/obo/HP_0003254	Abnormality of DNA repair	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An abnormality of the process of DNA repair, that is, of the process of restoring DNA after damage.
http://purl.obolibrary.org/obo/HP_0003256	Abnormality of the coagulation cascade	http://purl.obolibrary.org/obo/HP_0001928	Abnormality of coagulation		An abnormality of the coagulation cascade, which is comprised of the contact activation pathway (also known as the intrinsic pathway) and the tissue factor pathway (also known as the extrinsic pathway) as well as cofactors and regulators.
http://purl.obolibrary.org/obo/HP_0003259	Elevated circulating creatinine concentration	http://purl.obolibrary.org/obo/HP_0012100	Abnormal circulating creatinine concentration		An increased amount of creatinine in the blood.
http://purl.obolibrary.org/obo/HP_0003260	Hydroxyprolinemia	http://purl.obolibrary.org/obo/HP_0010907	Abnormal circulating proline concentration		The concentration of hydroxyproline in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003261	Increased circulating IgA concentration	http://purl.obolibrary.org/obo/HP_0410240	Abnormal circulating IgA concentration		An abnormally increased level of immunoglobulin A in blood.
http://purl.obolibrary.org/obo/HP_0003262	Anti-smooth muscle antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence in serum of antibodies against smooth muscle.
http://purl.obolibrary.org/obo/HP_0003265	Neonatal hyperbilirubinemia	http://purl.obolibrary.org/obo/HP_0002904	Hyperbilirubinemia		A type of hyperbilirubinemia with neonatal onset.
http://purl.obolibrary.org/obo/HP_0003267	Reduced orotidine 5-prime phosphate decarboxylase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormal decrease in orotidine 5'-phosphate decarboxylase level.
http://purl.obolibrary.org/obo/HP_0003268	Argininuria	http://purl.obolibrary.org/obo/HP_0033093	Increased glutamine family amino acid level in urine		A increased concentration of arginine in the urine.
http://purl.obolibrary.org/obo/HP_0003270	Abdominal distention	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Distention of the abdomen.
http://purl.obolibrary.org/obo/HP_0003271	Visceromegaly	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		Abnormal increased size of the viscera of the abdomen.
http://purl.obolibrary.org/obo/HP_0003272	Abnormal hip bone morphology	http://purl.obolibrary.org/obo/HP_0002644	Abnormal pelvic girdle bone morphology		An abnormality of the hip bone.
http://purl.obolibrary.org/obo/HP_0003273	Hip contracture	http://purl.obolibrary.org/obo/HP_0005750	Lower-limb joint contracture		Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the hip joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.
http://purl.obolibrary.org/obo/HP_0003274	Hypoplastic acetabulae	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		Underdeveloped acetabulae.
http://purl.obolibrary.org/obo/HP_0003275	Narrow pelvis bone	http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology		Reduced side to side width of the pelvis.
http://purl.obolibrary.org/obo/HP_0003276	Pelvic bone exostoses	http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology		A benign growth the projects outward from the bone surface of the pelvis. Exostoses are capped by cartilage, and arise from a bone that develops from cartilage.
http://purl.obolibrary.org/obo/HP_0003278	Square pelvis bone	http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology		An abnormally squared appearance of the bony pelvis, a normally rounded or basin-shaped structure.
http://purl.obolibrary.org/obo/HP_0003279	Coxa magna	http://purl.obolibrary.org/obo/HP_0003272	Abnormal hip bone morphology		Widening of the femoral head and neck.
http://purl.obolibrary.org/obo/HP_0003281	Increased circulating ferritin concentration	http://purl.obolibrary.org/obo/HP_0040133	Abnormal circulating ferritin concentration		Increased concentration of ferritin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity	http://purl.obolibrary.org/obo/HP_0004379	Abnormality of alkaline phosphatase level		Concentration or activity of alkaline phosphatase outside the upper or lower limtis of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0003286	Cystathioninemia	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		An increased concentration of cystathionine in the blood.
http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism	http://purl.obolibrary.org/obo/HP_0012103	Abnormality of the mitochondrion		A functional anomaly of mitochondria.
http://purl.obolibrary.org/obo/HP_0003292	Decreased serum leptin	http://purl.obolibrary.org/obo/HP_0004361	Abnormal circulating leptin concentration		A decreased concentration of leptin in the blood.
http://purl.obolibrary.org/obo/HP_0003296	Hyperthreoninuria	http://purl.obolibrary.org/obo/HP_0033096	Increased aspartate family amino acid level in urine		An increased concentration of threonine in the urine.
http://purl.obolibrary.org/obo/HP_0003297	Hyperlysinuria	http://purl.obolibrary.org/obo/HP_0033096	Increased aspartate family amino acid level in urine		An increased concentration of lysine in the urine.
http://purl.obolibrary.org/obo/HP_0003298	Spina bifida occulta	http://purl.obolibrary.org/obo/HP_0002414	Spina bifida		The closed form of spina bifida with incomplete closure of a vertebral body with intact overlying skin.
http://purl.obolibrary.org/obo/HP_0003300	Ovoid vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		When viewed in lateral radiographs, vertebral bodies have a roughly rectangular configuration. This term applies if the vertebral body appears rounded or oval.
http://purl.obolibrary.org/obo/HP_0003301	Irregular vertebral endplates	http://purl.obolibrary.org/obo/HP_0005106	Abnormality of the vertebral endplates		An irregular surface of the vertebral end plates, which are normally relatively smooth.
http://purl.obolibrary.org/obo/HP_0003302	Spondylolisthesis	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra.
http://purl.obolibrary.org/obo/HP_0003304	Spondylolysis	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Spondylolysis is an osseous defect of the pars interarticularis, thought to be a developmental or acquired stress fracture secondary to chronic low-grade trauma.
http://purl.obolibrary.org/obo/HP_0003305	Block vertebrae	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		Congenital synostosis between two or more adjacent vertebrae (partial or complete fusion of adjacent vertabral bodies).
http://purl.obolibrary.org/obo/HP_0003306	Spinal rigidity	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Reduced ability to move the vertebral column with a resulting limitation of neck and trunk flexion.
http://purl.obolibrary.org/obo/HP_0003308	Cervical subluxation	http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation		A partial dislocation of one or more intervertebral joints in the cervical vertebral column.
http://purl.obolibrary.org/obo/HP_0003310	Abnormal odontoid process morphology	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Abnormal structure of the odontoid process, which is a part of the C2 or axis vertebra and forms pivot of the structures forming the craniovertebral junction. The odontoid process is also known as the dens of the axis.
http://purl.obolibrary.org/obo/HP_0003311	Hypoplasia of the odontoid process	http://purl.obolibrary.org/obo/HP_0008518	Aplasia/Hypoplasia involving the vertebral column		Developmental hypoplasia of the dens of the axis.
http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		Abnormal form of vertebral body, which is the central cylindrical portion of the vertebra that together with other structures such as the vertebral arch, pedicles, laminae, spinous process, transverse processes, and articular facets makes up a vertebra.
http://purl.obolibrary.org/obo/HP_0003316	Butterfly vertebrae	http://purl.obolibrary.org/obo/HP_0008428	Vertebral clefting		A butterfly vertebra (sagittal cleft vertebra or anterior rachischisis) is a sagittal defect in the vertebral body caused by failure of fusion of the two lateral chondrification centers during embryogenesis. The name is based on the appearance of the two hemivertebrae emerging as butterfly wings from the central cleft on x-ray.
http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Any abnormality of the cervical vertebral column.
http://purl.obolibrary.org/obo/HP_0003320	C1-C2 subluxation	http://purl.obolibrary.org/obo/HP_0008440	C1-C2 vertebral abnormality		A partial dislocation of the atlantoaxial joints.
http://purl.obolibrary.org/obo/HP_0003324	Generalized muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Generalized weakness or decreased strength of the muscles, affecting both distal and proximal musculature.
http://purl.obolibrary.org/obo/HP_0003325	Limb-girdle muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Weakness of the limb-girdle muscles (also known as the pelvic and shoulder girdles), that is, lack of strength of the muscles around the shoulders and the pelvis.
http://purl.obolibrary.org/obo/HP_0003326	Myalgia	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain in muscle.
http://purl.obolibrary.org/obo/HP_0003327	Axial muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Reduced strength of the axial musculature (i.e., of the muscles of the head and neck, spine, and ribs).
http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		An abnormal structure of the hairshaft, i.e., of the nongrowing portion of a hair that protrudes from the skin.
http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Any anomaly in the composite material or the layered arrangement of the bony skeleton.
http://purl.obolibrary.org/obo/HP_0003333	Elevated circulating beta-hexosaminidase activity	http://purl.obolibrary.org/obo/HP_0011021	Abnormal circulating enzyme concentration		The activity of beta-hexosaminidase in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003334	Elevated circulating catecholamine level	http://purl.obolibrary.org/obo/HP_0012099	Abnormal circulating catecholamine concentration		An abnormal increase in catecholamine concentration in the blood.
http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification	http://purl.obolibrary.org/obo/HP_0011849	Abnormal bone ossification		An abnormality of the process of endochondral ossification, which is a type of replacement ossification in which bone tissue replaces cartilage.
http://purl.obolibrary.org/obo/HP_0003337	Reduced prothrombin consumption	http://purl.obolibrary.org/obo/HP_0012200	Abnormality of prothrombin		The prothrombin consumption test measures the formation of intrinsic thromboplastin by determining the residual serum prothrombin after blood clotting is complete. If there is a defect in the process, less prothrombin will be converted to thrombin than normal (less prothrombin is consumed). This test may be abnormal with conditions including deficiency of factors VIII or IX, with circulating anticoagulants, thrombocytopenia.
http://purl.obolibrary.org/obo/HP_0003339	Pyrimidine-responsive megaloblastic anemia	http://purl.obolibrary.org/obo/HP_0001889	Megaloblastic anemia		A type of megaloblastic anemia that improves upon administration of pyrimidine supplements such as uridylic acid and cytidylic acid.
http://purl.obolibrary.org/obo/HP_0003341	Lamina lucida cleavage	http://purl.obolibrary.org/obo/HP_0033804	Subepidermal blistering		The formation of bullae (blisters) with cleavage in the lamina lucida layer of the skin.
http://purl.obolibrary.org/obo/HP_0003343	Reduced glutathione synthetase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced level of the enzyme glutathione synthetase, which catalyzes the last step in the synthesis of glutathione and a deficiency results in low levels of glutathione. Acidosis is due to reduced feedback inhibition of gamma-glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline.
http://purl.obolibrary.org/obo/HP_0003344	3-Methylglutaric aciduria	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		An abnormally increased level of 3-hydroxy-3-methylglutaric acid in the urine.
http://purl.obolibrary.org/obo/HP_0003345	Elevated urinary norepinephrine level	http://purl.obolibrary.org/obo/HP_0011976	Elevated urinary catecholamine level		The concentration of noradrenaline in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003348	Hyperalaninemia	http://purl.obolibrary.org/obo/HP_0010916	Abnormal circulating alanine concentration		An increased concentration of alanine in the blood.
http://purl.obolibrary.org/obo/HP_0003349	Low cholesterol esterification rate	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		A reduction in the rate of cholesterol esterification.
http://purl.obolibrary.org/obo/HP_0003351	Decreased circulating renin concentration	http://purl.obolibrary.org/obo/HP_0040084	Abnormal circulating renin concentration		An decreased level of renin in the blood.
http://purl.obolibrary.org/obo/HP_0003352	Endopolyploidy on chromosome studies of bone marrow	http://purl.obolibrary.org/obo/HP_0002916	Abnormality of chromosome segregation		An increase in the number of chromosome sets per cell in bone marrow cells.
http://purl.obolibrary.org/obo/HP_0003353	Propionyl-CoA carboxylase deficiency	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormality of amino acid metabolism characterized by a decreased level of propionyl-CoA carboxylase.
http://purl.obolibrary.org/obo/HP_0003354	Hyperthreoninemia	http://purl.obolibrary.org/obo/HP_0010900	Abnormal circulating threonine concentration		The concentration of threonine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003357	Thymic hormone decreased	http://purl.obolibrary.org/obo/HP_0000777	Abnormal thymus morphology		A reduction in the level of thymic horomone.
http://purl.obolibrary.org/obo/HP_0003358	Elevated intracellular cystine	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An increased concentration of cystine within cells. This finding can be demonstrated on leukocytes, but is not specific to blood cells.
http://purl.obolibrary.org/obo/HP_0003359	Decreased urinary sulfate	http://purl.obolibrary.org/obo/HP_0012612	Abnormal urinary sulfate concentration		Decreased concentration of sulfate in the urine.
http://purl.obolibrary.org/obo/HP_0003361	Tryptophanuria	http://purl.obolibrary.org/obo/HP_0033090	Increased aromatic amino acid level in urine		An increased concentration of tryptophan in the urine.
http://purl.obolibrary.org/obo/HP_0003362	Elevated circulating VLDL-C concentration	http://purl.obolibrary.org/obo/HP_0031889	Abnormal circulating VLDL-C concentration		The concentration of very-low-density lipoprotein cholesterol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003363	Abdominal situs inversus	http://purl.obolibrary.org/obo/HP_0011620	Abnormality of abdominal situs		A left-right reversal (or mirror reflection) of the anatomical location of the viscera of the abdomen.
http://purl.obolibrary.org/obo/HP_0003365	Arthralgia of the hip	http://purl.obolibrary.org/obo/HP_0003272	Abnormal hip bone morphology		Joint pain affecting the hip.
http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology	http://purl.obolibrary.org/obo/HP_0003366	Abnormal femoral neck/head morphology		An abnormality of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).
http://purl.obolibrary.org/obo/HP_0003368	Abnormal femoral head morphology	http://purl.obolibrary.org/obo/HP_0003366	Abnormal femoral neck/head morphology		An abnormality of the femoral head.
http://purl.obolibrary.org/obo/HP_0003370	Flat capital femoral epiphysis	http://purl.obolibrary.org/obo/HP_0030289	Flattened femoral epiphysis		An abnormal flattening of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0003371	Enlargement of the proximal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0010580	Enlarged epiphyses		An abnormal enlargement of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0003375	Narrow greater sciatic notch	http://purl.obolibrary.org/obo/HP_0010456	Abnormal greater sciatic notch morphology		A narrowing of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium.
http://purl.obolibrary.org/obo/HP_0003376	Steppage gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		An abnormal gait pattern that arises from weakness of the pretibial and peroneal muscles due to a lower motor neuron lesion. Affected patients have footdrop and are unable to dorsiflex and evert the foot. The leg is lifted high on walking so that the toes clear the ground, and there may be a slapping noise when the foot strikes the ground again.
http://purl.obolibrary.org/obo/HP_0003378	Axonal degeneration/regeneration	http://purl.obolibrary.org/obo/HP_0000764	Peripheral axonal degeneration		A pattern of simultaneous degeneration and regeneration of axons (see comment).
http://purl.obolibrary.org/obo/HP_0003380	Decreased number of peripheral myelinated nerve fibers	http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination		A loss of myelinated nerve fibers in the peripheral nervous system (in general, this finding can be observed on nerve biopsy).
http://purl.obolibrary.org/obo/HP_0003383	Onion bulb formation	http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination		Repeated episodes of segmental demyelination and remyelination lead to the accumulation of supernumerary Schwann cells around axons, which is referred to as onion bulb formation. This finding affects peripheral nerves.
http://purl.obolibrary.org/obo/HP_0003384	Peripheral axonal atrophy	http://purl.obolibrary.org/obo/HP_0000764	Peripheral axonal degeneration		Atrophic changes of axons of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0003387	Decreased number of large peripheral myelinated nerve fibers	http://purl.obolibrary.org/obo/HP_0003380	Decreased number of peripheral myelinated nerve fibers		A reduced number of large myelinated nerve fibers.
http://purl.obolibrary.org/obo/HP_0003388	Easy fatigability	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		Increased susceptibility to fatigue.
http://purl.obolibrary.org/obo/HP_0003390	Sensory axonal neuropathy	http://purl.obolibrary.org/obo/HP_0003477	Peripheral axonal neuropathy		An axonal neuropathy of peripheral sensory nerves.
http://purl.obolibrary.org/obo/HP_0003391	Gowers sign	http://purl.obolibrary.org/obo/HP_0003701	Proximal muscle weakness		A phenomenon whereby patients are not able to stand up without the use of the hands owing to weakness of the proximal muscles of the lower limbs.
http://purl.obolibrary.org/obo/HP_0003393	Thenar muscle atrophy	http://purl.obolibrary.org/obo/HP_0009130	Hand muscle atrophy		Wasting of thenar muscles, which are located on palm of the hand at the base of the thumb.
http://purl.obolibrary.org/obo/HP_0003394	Muscle spasm	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		Sudden and involuntary contractions of one or more muscles.
http://purl.obolibrary.org/obo/HP_0003396	Syringomyelia	http://purl.obolibrary.org/obo/HP_0100561	Spinal cord lesion		Dilated, glial-lined cavity in spinal cord. This cavity does not communicate with the central canal, and usually is between the dorsal columns unilaterally or bilaterally along the side of the cord.
http://purl.obolibrary.org/obo/HP_0003398	Abnormal synaptic transmission at the neuromuscular junction	http://purl.obolibrary.org/obo/HP_0030191	Abnormal peripheral nervous system synaptic transmission		Any abnormality of the neuromuscular junction, which is the synapse between the motor end plate of a motor neuron and the skeletal muscle fibers.
http://purl.obolibrary.org/obo/HP_0003400	Basal lamina onion bulb formation	http://purl.obolibrary.org/obo/HP_0003383	Onion bulb formation		A type of onion bulb formation prominently affecting the area of the basal lamina.
http://purl.obolibrary.org/obo/HP_0003402	Decreased miniature endplate potentials	http://purl.obolibrary.org/obo/HP_0003398	Abnormal synaptic transmission at the neuromuscular junction		An abnormal reduction in the amplitude of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction.
http://purl.obolibrary.org/obo/HP_0003403	EMG: decremental response of compound muscle action potential to repetitive nerve stimulation	http://purl.obolibrary.org/obo/HP_0100285	EMG: impaired neuromuscular transmission		A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to a greater than normal decrease in the amplitude during the course of the investigation.
http://purl.obolibrary.org/obo/HP_0003409	Distal sensory impairment of all modalities	http://purl.obolibrary.org/obo/HP_0000763	Sensory neuropathy		Reduced ability to sense pain, temperature, touch, vibration stimuli in the distal regions of the extremities.
http://purl.obolibrary.org/obo/HP_0003411	Proximal femoral metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0030291	Lower-limb metaphyseal irregularity		Irregularity of the normally smooth surface of the proximal metaphysis of the femur.
http://purl.obolibrary.org/obo/HP_0003413	Atlantoaxial abnormality	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		An anomaly of the atlantoaxial joint, i.e., of the joint between the first (atlas) and second (axis) cervical vertebrae.
http://purl.obolibrary.org/obo/HP_0003414	Atlantoaxial dislocation	http://purl.obolibrary.org/obo/HP_0003413	Atlantoaxial abnormality		Partial dislocation of the atlantoaxial joint.
http://purl.obolibrary.org/obo/HP_0003416	Spinal canal stenosis	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		An abnormal narrowing of the spinal canal.
http://purl.obolibrary.org/obo/HP_0003417	Coronal cleft vertebrae	http://purl.obolibrary.org/obo/HP_0008428	Vertebral clefting		Frontal schisis (cleft or cleavage) of vertebral bodies.
http://purl.obolibrary.org/obo/HP_0003419	Low back pain	http://purl.obolibrary.org/obo/HP_0003418	Back pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the lower back.
http://purl.obolibrary.org/obo/HP_0003422	Vertebral segmentation defect	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		An abnormality related to a defect of vertebral separation during development.
http://purl.obolibrary.org/obo/HP_0003429	CNS hypomyelination	http://purl.obolibrary.org/obo/HP_0011400	Abnormal CNS myelination		Reduced amount of myelin in the central nervous system resulting from defective myelinogenesis.
http://purl.obolibrary.org/obo/HP_0003431	Decreased motor nerve conduction velocity	http://purl.obolibrary.org/obo/HP_0040131	Abnormal motor nerve conduction velocity		A type of decreased nerve conduction velocity that affects the motor neuron.
http://purl.obolibrary.org/obo/HP_0003436	Prolonged miniature endplate currents	http://purl.obolibrary.org/obo/HP_0003398	Abnormal synaptic transmission at the neuromuscular junction		An abnormal prolongation of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction.
http://purl.obolibrary.org/obo/HP_0003438	Absent Achilles reflex	http://purl.obolibrary.org/obo/HP_0200101	Decreased/absent ankle reflexes		Absence of the Achilles reflex (also known as the ankle jerk reflex), which can normally be elicited by tapping the tendon is tapped while the foot is dorsiflexed.
http://purl.obolibrary.org/obo/HP_0003443	Decreased size of nerve terminals	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		A reduction in the size of nerve terminals.
http://purl.obolibrary.org/obo/HP_0003444	EMG: chronic denervation signs	http://purl.obolibrary.org/obo/HP_0003445	EMG: neuropathic changes		Evidence of chronic denervation on electromyography.
http://purl.obolibrary.org/obo/HP_0003445	EMG: neuropathic changes	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		The presence of characteristic findings of denervation on electromyography (fibrillations, positive sharp waves, and giant motor unit potentials).
http://purl.obolibrary.org/obo/HP_0003447	Axonal loss	http://purl.obolibrary.org/obo/HP_0000764	Peripheral axonal degeneration		A reduction in the number of axons in the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0003448	Decreased sensory nerve conduction velocity	http://purl.obolibrary.org/obo/HP_0040132	Abnormal sensory nerve conduction velocity		Reduced speed of conduction of the action potential along a sensory nerve.
http://purl.obolibrary.org/obo/HP_0003449	Cold-induced muscle cramps	http://purl.obolibrary.org/obo/HP_0003394	Muscle spasm		Sudden and involuntary contractions of one or more muscles brought on by exposure to cold temperatures.
http://purl.obolibrary.org/obo/HP_0003450	Axonal regeneration	http://purl.obolibrary.org/obo/HP_0000764	Peripheral axonal degeneration		The presence of axonal regeneration following a previous axonal lesion.
http://purl.obolibrary.org/obo/HP_0003451	Increased rate of premature chromosome condensation	http://purl.obolibrary.org/obo/HP_0011019	Abnormality of chromosome condensation		An increased rate of premature chromosome condensation.
http://purl.obolibrary.org/obo/HP_0003452	Elevated circulating iron concentration	http://purl.obolibrary.org/obo/HP_0040130	Abnormal circulating iron concentration		The concentration of iron cation in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003453	Antineutrophil antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against neutrophils.
http://purl.obolibrary.org/obo/HP_0003454	Platelet antibody positive	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence in the serum of autoantibodies directed against thrombocytes.
http://purl.obolibrary.org/obo/HP_0003455	Elevated circulating long chain fatty acid concentration	http://purl.obolibrary.org/obo/HP_0010964	Abnormal circulating long-chain fatty-acid concentration		Increased concentration of long-chain fatty acids in the blood circulation.
http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		Abnormal results of investigations using electromyography (EMG).
http://purl.obolibrary.org/obo/HP_0003458	EMG: myopathic abnormalities	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		The presence of abnormal electromyographic patterns indicative of myopathy, such as small-short polyphasic motor unit potentials.
http://purl.obolibrary.org/obo/HP_0003459	Polyclonal elevation of circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0003496	Increased circulating IgM concentration		A heterogeneous increase in IgM immunoglobulins characterized by a diffuse band on serum electrophoresis.
http://purl.obolibrary.org/obo/HP_0003460	Chronic decreased circulating IgA concentration	http://purl.obolibrary.org/obo/HP_0002720	Decreased circulating IgA concentration		Undetectable serum immunoglobulin A level at a value < 5 mg/dL (0.05 g/L).
http://purl.obolibrary.org/obo/HP_0003461	Increased urinary O-linked sialopeptides	http://purl.obolibrary.org/obo/HP_0012067	Glycopeptiduria		Excretion of peptides conjugated to sialic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003463	Increased extraneuronal autofluorescent lipopigment	http://purl.obolibrary.org/obo/HP_0011813	Increased cerebral lipofuscin		Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the extraneuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient.
http://purl.obolibrary.org/obo/HP_0003467	Atlantoaxial instability	http://purl.obolibrary.org/obo/HP_0003413	Atlantoaxial abnormality		Abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly.
http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		An abnormality of one or more of the vertebrae.
http://purl.obolibrary.org/obo/HP_0003469	Peripheral dysmyelination	http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination		Defective structure and function of myelin sheaths. Dysmyelination is distinguished from demyleination where there is destruction or damage of previously normal myelination.
http://purl.obolibrary.org/obo/HP_0003472	Hypocalcemic tetany	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		Hyperexcitability of the neuromuscular system related to abnormally low level of calcium in the blood, resulting in carpopedal or generalized spasms.
http://purl.obolibrary.org/obo/HP_0003473	Fatigable weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0003477	Peripheral axonal neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		An abnormality characterized by disruption of the normal functioning of peripheral axons.
http://purl.obolibrary.org/obo/HP_0003481	Segmental peripheral demyelination/remyelination	http://purl.obolibrary.org/obo/HP_0011096	Peripheral demyelination		A segmental pattern of demyelination and regeneration (remyelination) affecting peripheral nerves.
http://purl.obolibrary.org/obo/HP_0003482	EMG: axonal abnormality	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		Electromyographic (EMG) findings characteristic of axonal neuropathy, with normal or slightly decreased nerve conduction velocities, normal or slightly prolonged distal latencies, but significantly reduced motor potentials and sensory amplitudes. There may be spontaneous activity upon needle EMG studies, such as increased insertional activity, positive sharp waves, and fibrillation potentials.
http://purl.obolibrary.org/obo/HP_0003484	Upper limb muscle weakness	http://purl.obolibrary.org/obo/HP_0003690	Limb muscle weakness		Weakness of the muscles of the arms.
http://purl.obolibrary.org/obo/HP_0003487	Babinski sign	http://purl.obolibrary.org/obo/HP_0031828	Abnormal superficial reflex		Upturning of the big toe (and sometimes fanning of the other toes) in response to stimulation of the sole of the foot. If the Babinski sign is present it can indicate damage to the corticospinal tract.
http://purl.obolibrary.org/obo/HP_0003491	Elevated urine pyrophosphate	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An abnormally increased diphosphate(4-) concentration in the urine. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate.
http://purl.obolibrary.org/obo/HP_0003492	High urinary gonadotropin level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism.
http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against nuclei or nuclear components.
http://purl.obolibrary.org/obo/HP_0003495	GM2-ganglioside accumulation	http://purl.obolibrary.org/obo/HP_0004345	Ganglioside accumulation		Cellular accumulation of GM2 gangliosides.
http://purl.obolibrary.org/obo/HP_0003496	Increased circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0410243	Abnormal circulating IgM concentration		An abnormally increased level of immunoglobulin M in blood.
http://purl.obolibrary.org/obo/HP_0003498	Disproportionate short stature	http://purl.obolibrary.org/obo/HP_0004322	Short stature		A kind of short stature in which different regions of the body are shortened to differing extents.
http://purl.obolibrary.org/obo/HP_0003502	Mild short stature	http://purl.obolibrary.org/obo/HP_0003508	Proportionate short stature		A mild degree of short stature, more than -2 SD but not more than -3 SD from mean corrected for age and sex.
http://purl.obolibrary.org/obo/HP_0003508	Proportionate short stature	http://purl.obolibrary.org/obo/HP_0004322	Short stature		A kind of short stature in which different regions of the body are shortened to a comparable extent.
http://purl.obolibrary.org/obo/HP_0003513	Reduced ratio of renal calcium clearance to creatinine clearance	http://purl.obolibrary.org/obo/HP_0011280	Abnormality of urine calcium concentration		A reduction of the ratio of renal calcium clearance to creatinine clearance to below 0.01.
http://purl.obolibrary.org/obo/HP_0003524	Decreased methionine synthase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		A reduction in methionine synthase activity.
http://purl.obolibrary.org/obo/HP_0003526	Orotic acid crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		Formation of crystals owing to an increased concentration of orotic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003527	Hyperprostaglandinuria	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		An increased concentration of prostaglandin in the urine.
http://purl.obolibrary.org/obo/HP_0003528	Elevated circulating calcitonin concentration	http://purl.obolibrary.org/obo/HP_0034902	Abnormal circulating calcitonin concentration		Concentration of calcitonin, a 32-amino acid polypeptide hormone that is produced primarily by the parafollicular cells of the thyroid, in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003529	Parathormone-independent increased renal tubular calcium reabsorption	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		An increase in the reabsorption of calcium by the renal tubulus that is not associated with increased parathormone levels.
http://purl.obolibrary.org/obo/HP_0003530	Elevated circulating glutaric acid concentration	http://purl.obolibrary.org/obo/HP_0032368	Acidemia		An increased concentration of glutaric acid in the blood.
http://purl.obolibrary.org/obo/HP_0003532	Ornithinuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		Level of ornithine in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003533	Reduced acetaldehyde dehydrogenase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Decreased level of acetaldehyde dehydrogenase (ALDH). ALDH and alcohol dehydrogenase (ADH) are the primary enzymes involved in alcohol metabolism.
http://purl.obolibrary.org/obo/HP_0003534	Reduced xanthine dehydrogenase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormal reduction in xanthine dehydrogenase level.
http://purl.obolibrary.org/obo/HP_0003535	3-Methylglutaconic aciduria	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		An increased amount of 3-methylglutaconic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003536	Decreased fumarate hydratase activity	http://purl.obolibrary.org/obo/HP_0000816	Abnormality of Krebs cycle metabolism		An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of fumarate hydratase activity.
http://purl.obolibrary.org/obo/HP_0003537	Hypouricemia	http://purl.obolibrary.org/obo/HP_0010932	Abnormal circulating nucleobase concentration		The concentration of uric acid in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0003538	Increased iduronate sulfatase level	http://purl.obolibrary.org/obo/HP_0034202	Abnormal iduronate sulfatase concentration		An increased level of iduronate-2-sulfatase activity in the blood.
http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation	http://purl.obolibrary.org/obo/HP_0030402	Abnormal platelet aggregation		An impairment in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent.
http://purl.obolibrary.org/obo/HP_0003541	Urinary glycosaminoglycan excretion	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Excretion of glycosaminoglycan in the urine. Glycosaminoglycans are long unbranched polysaccharides consisting of a repeating disaccharide unit.
http://purl.obolibrary.org/obo/HP_0003542	Increased circulating pyruvate concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of pyruvate in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003546	Exercise intolerance	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender.
http://purl.obolibrary.org/obo/HP_0003547	Shoulder girdle muscle weakness	http://purl.obolibrary.org/obo/HP_0003325	Limb-girdle muscle weakness		The shoulder, or pectoral, girdle is composed of the clavicles and the scapulae. Shoulder-girdle weakness refers to lack of strength of the muscles attaching to these bones, that is, lack of strength of the muscles around the shoulders.
http://purl.obolibrary.org/obo/HP_0003548	Subsarcolemmal accumulations of abnormally shaped mitochondria	http://purl.obolibrary.org/obo/HP_0003800	Muscle abnormality related to mitochondrial dysfunction		An abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology.
http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue	http://purl.obolibrary.org/obo/HP_0033127	Abnormality of the musculoskeletal system		Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat).
http://purl.obolibrary.org/obo/HP_0003550	Predominantly lower limb lymphedema	http://purl.obolibrary.org/obo/HP_0001004	Lymphedema		Localized fluid retention and tissue swelling caused by a compromised lymphatic system, affecting mainly the legs.
http://purl.obolibrary.org/obo/HP_0003551	Difficulty climbing stairs	http://purl.obolibrary.org/obo/HP_0004302	Functional motor deficit		Reduced ability to climb stairs.
http://purl.obolibrary.org/obo/HP_0003552	Muscle stiffness	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		A condition in which muscles cannot be moved quickly without accompanying pain or spasm.
http://purl.obolibrary.org/obo/HP_0003554	Type 2 muscle fiber atrophy	http://purl.obolibrary.org/obo/HP_0100295	Muscle fiber atrophy		Atrophy (wasting) affecting primary type 2 muscle fibers. This feature in general can only be observed on muscle biopsy.
http://purl.obolibrary.org/obo/HP_0003555	Muscle fiber splitting	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches.
http://purl.obolibrary.org/obo/HP_0003557	Increased variability in muscle fiber diameter	http://purl.obolibrary.org/obo/HP_0012084	Abnormality of skeletal muscle fiber size		An abnormally high degree of muscle fiber size variation. This phenotypic feature can be observed upon muscle biopsy.
http://purl.obolibrary.org/obo/HP_0003558	Viral infection-induced rhabdomyolysis	http://purl.obolibrary.org/obo/HP_0003201	Rhabdomyolysis		Rhabdomyolysis induced by a viral infection.
http://purl.obolibrary.org/obo/HP_0003563	Decreased circulating LDL-C concentration	http://purl.obolibrary.org/obo/HP_0031886	Abnormal LDL cholesterol concentration		The concentration of low-density lipoprotein cholesterol in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0003564	Folate-dependent fragile site at Xq28	http://purl.obolibrary.org/obo/HP_0040012	Chromosome breakage		The presence of a folate sensitive fragile site at chromosome Xq28.
http://purl.obolibrary.org/obo/HP_0003565	Elevated erythrocyte sedimentation rate	http://purl.obolibrary.org/obo/HP_0025021	Abnormal erythrocyte sedimentation rate		An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.
http://purl.obolibrary.org/obo/HP_0003566	Increased serum prostaglandin E2	http://purl.obolibrary.org/obo/HP_0011023	Abnormal circulating prostaglandin concentration		An increased concentration of prostaglandin E2 in the blood.
http://purl.obolibrary.org/obo/HP_0003568	Decreased glucosephosphate isomerase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		A decreased level of glucose-6-phosphate isomerase.
http://purl.obolibrary.org/obo/HP_0003570	Molybdenum cofactor deficiency	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Absence of molybdenum cofactor(2-), a cofactor for enzymes including sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase.
http://purl.obolibrary.org/obo/HP_0003571	Propionic acidemia	http://purl.obolibrary.org/obo/HP_0032368	Acidemia		Increased concentration of proprionic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0003572	Low plasma citrulline	http://purl.obolibrary.org/obo/HP_0011965	Abnormal circulating citrulline concentration		A decreased concentration of citrulline in the blood.
http://purl.obolibrary.org/obo/HP_0003573	Increased total bilirubin	http://purl.obolibrary.org/obo/HP_0002904	Hyperbilirubinemia		Increased concentration of total (conjugated and unconjugated) bilirubin in the blood.
http://purl.obolibrary.org/obo/HP_0003574	Positive regitine blocking test	http://purl.obolibrary.org/obo/HP_0002640	Hypertension associated with pheochromocytoma		A positive response to the regitine blocking test consisting of a substantial reduction in blood pressure following administration of regitine, indicative of the presence of increased levels of epinephrine and norepinephrine in the circulation, which is seen in pheochromocytoma-associated hypertension.
http://purl.obolibrary.org/obo/HP_0003575	Increased intracellular sodium	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An abnormally increased sodium concentration in the cytosol.
http://purl.obolibrary.org/obo/HP_0003577	Congenital onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		A phenotypic abnormality that is present at birth.
http://purl.obolibrary.org/obo/HP_0003581	Adult onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later.
http://purl.obolibrary.org/obo/HP_0003584	Late onset	http://purl.obolibrary.org/obo/HP_0003581	Adult onset		A type of adult onset with onset of symptoms after the age of 60 years.
http://purl.obolibrary.org/obo/HP_0003587	Insidious onset	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Gradual, very slow onset of disease manifestations.
http://purl.obolibrary.org/obo/HP_0003593	Infantile onset	http://purl.obolibrary.org/obo/HP_0410280	Pediatric onset		Onset of signs or symptoms of disease between 28 days to one year of life.
http://purl.obolibrary.org/obo/HP_0003596	Middle age onset	http://purl.obolibrary.org/obo/HP_0003581	Adult onset		A type of adult onset with onset of symptoms at the age of 40 to 60 years.
http://purl.obolibrary.org/obo/HP_0003606	Absent urinary urothione	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Lack of urothione (the urinary metabolite of molybdenum cofactor) in the urine.
http://purl.obolibrary.org/obo/HP_0003607	4-hydroxyphenylacetic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Increased concentration of 4-hydroxyphenylacetic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003609	Foam cells with lamellar inclusion bodies	http://purl.obolibrary.org/obo/HP_0003651	Foam cells		The presence of foam cells that contain lamellar inclusion bodies.
http://purl.obolibrary.org/obo/HP_0003610	Fibroblast metachromasia	http://purl.obolibrary.org/obo/HP_0003653	Cellular metachromasia		Increased cytoplasmic staining of fibroblasts with toluidine blue.
http://purl.obolibrary.org/obo/HP_0003612	Positive ferric chloride test	http://purl.obolibrary.org/obo/HP_0010893	Abnormal circulating phenylalanine concentration		If positive, the ferric chloride test indicates an increased concentration of phenols in the urine or blood.
http://purl.obolibrary.org/obo/HP_0003613	Antiphospholipid antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of circulating autoantibodies to phospholipids.
http://purl.obolibrary.org/obo/HP_0003614	Trimethylaminuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Increased concentration of trimethylamine in the urine.
http://purl.obolibrary.org/obo/HP_0003621	Juvenile onset	http://purl.obolibrary.org/obo/HP_0410280	Pediatric onset		Onset of signs or symptoms of disease between the age of 5 and 15 years.
http://purl.obolibrary.org/obo/HP_0003623	Neonatal onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		Onset of signs or symptoms of disease within the first 28 days of life.
http://purl.obolibrary.org/obo/HP_0003634	Amyoplasia	http://purl.obolibrary.org/obo/HP_0100854	Aplasia of the musculature		Congenital lack of development of the muscles, which are then replaced by a mixture of dense fat and fibrous tissue.
http://purl.obolibrary.org/obo/HP_0003635	Loss of subcutaneous adipose tissue in limbs	http://purl.obolibrary.org/obo/HP_0008887	Adipose tissue loss		Loss (disappearance) of previously present subcutaneous fat tissue in arm or leg.
http://purl.obolibrary.org/obo/HP_0003637	Reduced circulating 4-Hydroxyphenylpyruvate dioxygenase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity or concentration of 4-hydroxyphenylpyruvate dioxygenase in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0003639	Elevated urinary epinephrine level	http://purl.obolibrary.org/obo/HP_0011976	Elevated urinary catecholamine level		The concentration of epinephrine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0003640	CNS foam cells	http://purl.obolibrary.org/obo/HP_0003651	Foam cells		The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, in the central nervous system.
http://purl.obolibrary.org/obo/HP_0003641	Hemoglobinuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The presence of free hemoglobin in the urine.
http://purl.obolibrary.org/obo/HP_0003642	Type I transferrin isoform profile	http://purl.obolibrary.org/obo/HP_0003160	Abnormal isoelectric focusing of serum transferrin		Abnormal transferrin isoform profile consistent with a type I congenital disorder of glycosylation. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II.
http://purl.obolibrary.org/obo/HP_0003643	Sulfite oxidase deficiency	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Abnormally reduced sulfite oxidase level.
http://purl.obolibrary.org/obo/HP_0003645	Prolonged partial thromboplastin time	http://purl.obolibrary.org/obo/HP_0001928	Abnormality of coagulation		Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms.
http://purl.obolibrary.org/obo/HP_0003646	Bicarbonaturia	http://purl.obolibrary.org/obo/HP_0011279	Abnormality of urine bicarbonate level		Abnormally increased concentration of hydrogencarbonate in the urine.
http://purl.obolibrary.org/obo/HP_0003647	Electron transfer flavoprotein-ubiquinone oxidoreductase defect	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		A deficiency of the electron transfer flavoprotein-ubiquinone oxidoreductase.
http://purl.obolibrary.org/obo/HP_0003648	Lacticaciduria	http://purl.obolibrary.org/obo/HP_0012072	Aciduria		An increased concentration of lactic acid in the urine.
http://purl.obolibrary.org/obo/HP_0003649	Abnormal glycosidase enzyme activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Abnormality of glycosidase enzyme activity. Glycoside hydrolases (GHs), including glycosidases and transglycosidases. These enzymes constitute 113 protein families that are responsible for the hydrolysis and/or transglycosylation of glycosidic bonds.
http://purl.obolibrary.org/obo/HP_0003651	Foam cells	http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis		The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.
http://purl.obolibrary.org/obo/HP_0003652	Recurrent myoglobinuria	http://purl.obolibrary.org/obo/HP_0002913	Myoglobinuria		Recurring episodes of myoglobinuria, i.e., of the presence of myoglobin in the urine. This is usually a consequence of rhabdomyolysis, i.e., of the destruction of muscle tissue.
http://purl.obolibrary.org/obo/HP_0003653	Cellular metachromasia	http://purl.obolibrary.org/obo/HP_0011020	Abnormality of mucopolysaccharide metabolism		Metachromasia (also known as metachromacy) is a characteristic color change which certain aniline dyes exhibit when bound to particular substances or when concentrated in solution. For example, the basic dye toluidine blue becomes distinctly pink when bound to cartilage matrix. In the sense used here, the metachromasia refers to a change in color not observed with normal tissues, anomalous staining with the cationic dyes toluidine blue O and Alcian blue resulting from excessive amounts of the polyanionic glycosaminoglycans.
http://purl.obolibrary.org/obo/HP_0003654	Reduced dihydropyrimidine dehydrogenase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormal reduction in dihydropyrimidine dehydrogenase (NADP+) level.
http://purl.obolibrary.org/obo/HP_0003655	Reduced level of N-acetylglucosaminyltransferase II	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormality of glycoprotein metabolism related to a decreased level of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity.
http://purl.obolibrary.org/obo/HP_0003656	Decreased beta-glucocerebrosidase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced level of the enzyme beta-glucosidase, an enzyme that catalyzes the hydrolysis of glucosylceramide into ceramide and glucose.
http://purl.obolibrary.org/obo/HP_0003657	Vascular granular osmiophilic material deposition	http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology		Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide. Deposition of granular osmiophilic material (GOM) is the vascular pathological hallmark of CADASIL, which is the most prevalent hereditary small vessel disease and is caused by missense mutations in the NOTCH3 gene. GOM have been shown to contain NOTCH3 ectodomain (NOTCH3ECD) and extracellular matrix proteins, and can be visualized ultrastructurally in the tunica media of small arteries and capillaries. These electron dense GOM deposits are located in the basement membrane of mural cells, i.e. vascular smooth muscle cells and pericytes. In both manifest and pre-manifest CADASIL patients, GOM deposits are present not only in brain vessels, but also in vessels of other organs, such as the skin.
http://purl.obolibrary.org/obo/HP_0003658	Hypomethioninemia	http://purl.obolibrary.org/obo/HP_0010901	Abnormal circulating methionine concentration		A decreased concentration of methionine in the blood.
http://purl.obolibrary.org/obo/HP_0003665	Amyotrophy of the musculature of the pelvis	http://purl.obolibrary.org/obo/HP_0008988	Pelvic girdle muscle atrophy		Muscular atrophy affecting the muscles of the pelvis.
http://purl.obolibrary.org/obo/HP_0003676	Progressive	http://purl.obolibrary.org/obo/HP_0003679	Pace of progression		Applies to a disease manifestation that increases in scope or severity over the course of time, i.e., that worsens with age.
http://purl.obolibrary.org/obo/HP_0003678	Rapidly progressive	http://purl.obolibrary.org/obo/HP_0003676	Progressive		Applies to a disease manifestation that quickly increases in scope or severity over the course of time.
http://purl.obolibrary.org/obo/HP_0003680	Nonprogressive	http://purl.obolibrary.org/obo/HP_0003679	Pace of progression		Applies to a disease manifestation that does not increase in scope or severity over the course of time, i.e., that does not worsen with age.
http://purl.obolibrary.org/obo/HP_0003682	Variable progression rate	http://purl.obolibrary.org/obo/HP_0003676	Progressive		Applies to a disease manifestation that quickly increases in scope or severity with a rate that varies. For instance, progression may be slow in one time period and rapid in another.
http://purl.obolibrary.org/obo/HP_0003687	Centrally nucleated skeletal muscle fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		An abnormality in which the nuclei of sarcomeres take on an abnormally central localization (or in which this feature is found in an increased proportion of muscle cells).
http://purl.obolibrary.org/obo/HP_0003688	Cytochrome C oxidase-negative muscle fibers	http://purl.obolibrary.org/obo/HP_0003800	Muscle abnormality related to mitochondrial dysfunction		An abnormally reduced activity of the enzyme cytochrome C oxidase in muscle tissue.
http://purl.obolibrary.org/obo/HP_0003689	Multiple mitochondrial DNA deletions	http://purl.obolibrary.org/obo/HP_0009141	Depletion of mitochondrial DNA in muscle tissue		The presence of multiple deletions of mitochondrial DNA (mtDNA).
http://purl.obolibrary.org/obo/HP_0003690	Limb muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Reduced strength and weakness of the muscles of the arms and legs.
http://purl.obolibrary.org/obo/HP_0003691	Scapular winging	http://purl.obolibrary.org/obo/HP_0001435	Abnormality of the shoulder girdle musculature		Abnormal protrusion of the scapula away from the surface of the back.
http://purl.obolibrary.org/obo/HP_0003693	Distal amyotrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Muscular atrophy affecting muscles in the distal portions of the extremities.
http://purl.obolibrary.org/obo/HP_0003694	Late-onset proximal muscle weakness	http://purl.obolibrary.org/obo/HP_0003701	Proximal muscle weakness		Lack of strength of the proximal musculature occurring late in the clinical course.
http://purl.obolibrary.org/obo/HP_0003696	Absent epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010246	Absent epiphyses of the distal phalanges of the hand		Absence of the epiphysis located at the proximal end of the distal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0003697	Scapuloperoneal amyotrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Muscular atrophy in the distribution of shoulder girdle and peroneal muscles.
http://purl.obolibrary.org/obo/HP_0003700	Generalized amyotrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Generalized (diffuse, unlocalized) amyotrophy (muscle atrophy) affecting multiple muscles.
http://purl.obolibrary.org/obo/HP_0003701	Proximal muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		A lack of strength of the proximal muscles.
http://purl.obolibrary.org/obo/HP_0003707	Calf muscle pseudohypertrophy	http://purl.obolibrary.org/obo/HP_0001430	Abnormal calf musculature morphology		Enlargement of the muscles of the calf due to their replacement by connective tissue or fat.
http://purl.obolibrary.org/obo/HP_0003710	Exercise-induced muscle cramps	http://purl.obolibrary.org/obo/HP_0003394	Muscle spasm		Sudden and involuntary contractions of one or more muscles brought on by physical exertion.
http://purl.obolibrary.org/obo/HP_0003712	Skeletal muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0030236	Abnormality of muscle size		Abnormal increase in muscle size and mass not due to training.
http://purl.obolibrary.org/obo/HP_0003713	Muscle fiber necrosis	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Abnormal cell death involving muscle fibers usually associated with break in, or absence of, muscle surface fiber membrane and resulting in irreversible damage to muscle fibers.
http://purl.obolibrary.org/obo/HP_0003715	Myofibrillar myopathy	http://purl.obolibrary.org/obo/HP_0003198	Myopathy		Myofibrillar structural changes characterized by abnormal intracellular accumulation of the intermediate filament desmin and other proteins.
http://purl.obolibrary.org/obo/HP_0003719	Muscle mounding	http://purl.obolibrary.org/obo/HP_0010548	Percussion myotonia		Percussion-induced, local prolonged contractions (mounding) in muscle persisting for several seconds.
http://purl.obolibrary.org/obo/HP_0003720	Generalized muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0003712	Skeletal muscle hypertrophy		Hypertrophy (increase in size) of muscle tissue in a generalized (not localized) distribution.
http://purl.obolibrary.org/obo/HP_0003722	Neck flexor weakness	http://purl.obolibrary.org/obo/HP_0000467	Neck muscle weakness		Weakness of the muscles involved in neck flexion (sternocleidomastoid, longus capitus, longus colli, and scalenus anterior).
http://purl.obolibrary.org/obo/HP_0003724	Shoulder girdle muscle atrophy	http://purl.obolibrary.org/obo/HP_0003797	Limb-girdle muscle atrophy		Amyotrophy affecting the muscles of the shoulder girdle.
http://purl.obolibrary.org/obo/HP_0003725	Firm muscles	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		A state of increased firmness (i.e., a reduced tendency to yield to pressure) of skeletal muscle tissue. This finding is ascertained by palpation and is to be distinguished from increased muscle tone (abnormal elevation in the resting tension of a muscle, leading to stiffness and resistance to movement).
http://purl.obolibrary.org/obo/HP_0003730	EMG: myotonic runs	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		Spontaneous, repetitive electrical activity demonstrated by electromyography (EMG).
http://purl.obolibrary.org/obo/HP_0003731	Quadriceps muscle weakness	http://purl.obolibrary.org/obo/HP_0008994	Proximal lower limb muscle weakness		Weakness of the quadriceps muscle (that is, of the muscle fasciculus of quadriceps femoris).
http://purl.obolibrary.org/obo/HP_0003733	Thigh hypertrophy	http://purl.obolibrary.org/obo/HP_0008968	Muscle hypertrophy of the lower extremities		Muscle hypertrophy affecting the thighs.
http://purl.obolibrary.org/obo/HP_0003736	Autophagic vacuoles	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		The lysosomal-vacuolar pathway has a role in the controlled intracellular digestion of macromolecules such as protein complexes and organelles. This feature refers to the presence of an abnormally increased number of autophagic vacuoles in muscle tissue.
http://purl.obolibrary.org/obo/HP_0003737	Mitochondrial myopathy	http://purl.obolibrary.org/obo/HP_0003800	Muscle abnormality related to mitochondrial dysfunction		A type of myopathy associated with mitochondrial disease and characterized by findings on biopsy such as ragged red muscle fibers.
http://purl.obolibrary.org/obo/HP_0003738	Exercise-induced myalgia	http://purl.obolibrary.org/obo/HP_0003326	Myalgia		The occurrence of an unusually high amount of muscle pain following exercise.
http://purl.obolibrary.org/obo/HP_0003740	Myotonia with warm-up phenomenon	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		Myotonia that occurs after a period of rest and decreases with continuing exercise.
http://purl.obolibrary.org/obo/HP_0003743	Genetic anticipation	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		A type of autosomal dominant inheritance involving a gene that exhibits anticipation, the increase in severity and/or an earlier age of onset in subsequent generations.
http://purl.obolibrary.org/obo/HP_0003744	Genetic anticipation with paternal anticipation bias	http://purl.obolibrary.org/obo/HP_0003743	Genetic anticipation		A type of genetic anticipation observed predominantly upon transmission from affected males.
http://purl.obolibrary.org/obo/HP_0003745	Sporadic	http://purl.obolibrary.org/obo/HP_0000005	Mode of inheritance		Cases of the disease in question occur without a previous family history, i.e., as isolated cases without being transmitted from a parent and without other siblings being affected.
http://purl.obolibrary.org/obo/HP_0003749	Pelvic girdle muscle weakness	http://purl.obolibrary.org/obo/HP_0003325	Limb-girdle muscle weakness		Weakness of the muscles of the pelvic girdle (also known as the hip girdle), that is, lack of strength of the muscles around the pelvis.
http://purl.obolibrary.org/obo/HP_0003750	Increased muscle fatiguability	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		An abnormal, increased fatiguability of the musculature.
http://purl.obolibrary.org/obo/HP_0003752	Episodic flaccid weakness	http://purl.obolibrary.org/obo/HP_0010547	Muscle flaccidity		Recurrent episodes of muscle flaccidity, a type of paralysis in which a muscle becomes soft and yields to passive stretching.
http://purl.obolibrary.org/obo/HP_0003755	Type 1 fibers relatively smaller than type 2 fibers	http://purl.obolibrary.org/obo/HP_0012084	Abnormality of skeletal muscle fiber size		The presence of abnormal muscle fiber size such that type 1 fibers are smaller than type 2 fibers.
http://purl.obolibrary.org/obo/HP_0003758	Reduced subcutaneous adipose tissue	http://purl.obolibrary.org/obo/HP_0040063	Decreased adipose tissue		A reduced amount of fat tissue in the lowest layer of the integument. This feature can be appreciated by a reduced skinfold thickness.
http://purl.obolibrary.org/obo/HP_0003759	Hypoplasia of lymphatic vessels	http://purl.obolibrary.org/obo/HP_0100766	Abnormal lymphatic vessel morphology		Congenital underdevelopment of lymph vessels.
http://purl.obolibrary.org/obo/HP_0003760	Percussion-induced rapid rolling muscle contractions	http://purl.obolibrary.org/obo/HP_0010548	Percussion myotonia		Mechanical percussion (i.e., striking a muscle with a reflex hammer) leads to spreading waves of muscle contractions that begin proximally and spread laterally across the muscle.
http://purl.obolibrary.org/obo/HP_0003761	Calcinosis	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Formation of calcium deposits in any soft tissue.
http://purl.obolibrary.org/obo/HP_0003762	Uterus didelphys	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		A malformation of the uterus in which the uterus is present as a paired organ as a result of the failure of fusion of the mullerian ducts during embryogenesis.
http://purl.obolibrary.org/obo/HP_0003763	Bruxism	http://purl.obolibrary.org/obo/HP_5200017	Stereotypic movements of face and head		Bruxism is characterized by the grinding of the teeth including the clenching of the jaw and typically occur during sleep.
http://purl.obolibrary.org/obo/HP_0003764	Nevus	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A nevus is a type of hamartoma that is a circumscribed stable malformation of the skin.
http://purl.obolibrary.org/obo/HP_0003765	Psoriasiform dermatitis	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales).
http://purl.obolibrary.org/obo/HP_0003768	Periodic paralysis	http://purl.obolibrary.org/obo/HP_0003470	Paralysis		Episodes of muscle weakness.
http://purl.obolibrary.org/obo/HP_0003771	Pulp calcification	http://purl.obolibrary.org/obo/HP_0006479	Abnormal dental pulp morphology		Pulp calcifications may appear as punctate calcifications, irregular, roughly spherical mineralized masses in any part of the pulp. It may occur isolated or associated to calcifications elsewhere such as the carotid arteries and kidneys. The diagnosis pulp calcifications can be established using radiological studies.
http://purl.obolibrary.org/obo/HP_0003774	Stage 5 chronic kidney disease	http://purl.obolibrary.org/obo/HP_0012622	Chronic kidney disease		A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine.
http://purl.obolibrary.org/obo/HP_0003777	Pili torti	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		Pili (from Latin pilus, hair) torti (from Latin tortus, twisted) refers to short and brittle hairs that appear flattened and twisted when viewed through a microscope.
http://purl.obolibrary.org/obo/HP_0003781	Excessive salivation	http://purl.obolibrary.org/obo/HP_0100755	Abnormality of salivation		Excessive production of saliva.
http://purl.obolibrary.org/obo/HP_0003782	Eunuchoid habitus	http://purl.obolibrary.org/obo/HP_0004325	Decreased body weight		A body habitus that is tall, slim and underweight, with long legs and long arms (i.e., arm span exceeds height by 5 cm or more).
http://purl.obolibrary.org/obo/HP_0003785	Decreased CSF homovanillic acid concentration	http://purl.obolibrary.org/obo/HP_0034200	Abnormal CSF homovanillic acid concentration		Decreased concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine.
http://purl.obolibrary.org/obo/HP_0003787	Type 1 and type 2 muscle fiber minicore regions	http://purl.obolibrary.org/obo/HP_0003789	Minicore myopathy		Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in type 1 and type 2 muscle fibers.
http://purl.obolibrary.org/obo/HP_0003789	Minicore myopathy	http://purl.obolibrary.org/obo/HP_0003198	Myopathy		Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in muscle fibers.
http://purl.obolibrary.org/obo/HP_0003795	Short middle phalanx of toe	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		Developmental hypoplasia (shortening) of middle phalanx of toe.
http://purl.obolibrary.org/obo/HP_0003796	Irregular iliac crest	http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology		Irregularity of the iliac crest, which is the superior border of the wing of the ilium.
http://purl.obolibrary.org/obo/HP_0003797	Limb-girdle muscle atrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Muscular atrophy affecting the muscles of the limb girdle.
http://purl.obolibrary.org/obo/HP_0003798	Nemaline bodies	http://purl.obolibrary.org/obo/HP_0100303	Muscle fiber cytoplasmatic inclusion bodies		Nemaline rods are abnormal bodies that can occur in skeletal muscle fibers. The rods can be observed on histological analysis of muscle biopsy tissue or upon electron microscopy, where they appear either as extensions of sarcomeric Z-lines, in random array without obvious attachment to Z-lines (often in areas devoid of sarcomeres) or in large clusters localized at the sarcolemma or intermyofibrillar spaces.
http://purl.obolibrary.org/obo/HP_0003803	Type 1 muscle fiber predominance	http://purl.obolibrary.org/obo/HP_0033684	Abnormal muscle fiber-type distribution		An abnormal predominance of type I muscle fibers (in general, this feature can only be observed on muscle biopsy).
http://purl.obolibrary.org/obo/HP_0003805	Rimmed vacuoles	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions.
http://purl.obolibrary.org/obo/HP_0003809	Reduced intrathoracic adipose tissue	http://purl.obolibrary.org/obo/HP_0040063	Decreased adipose tissue		An abnormally reduced amount of adipose tissue in the thoracic cavity.
http://purl.obolibrary.org/obo/HP_0003811	Neonatal death	http://purl.obolibrary.org/obo/HP_0011420	Age of death		Death within the first 28 days of life.
http://purl.obolibrary.org/obo/HP_0003812	Phenotypic variability	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		A variability of phenotypic features.
http://purl.obolibrary.org/obo/HP_0003819	Death in childhood	http://purl.obolibrary.org/obo/HP_0011420	Age of death		Death in during childhood, defined here as between the ages of 2 and 10 years.
http://purl.obolibrary.org/obo/HP_0003828	Variable expressivity	http://purl.obolibrary.org/obo/HP_0003812	Phenotypic variability		A variable severity of phenotypic features.
http://purl.obolibrary.org/obo/HP_0003829	Typified by incomplete penetrance	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Description of conditions in which not all individuals with a given genotype exhibit the disease. Penetrance is the proportion that develop disease given a lifespan of 80 years.
http://purl.obolibrary.org/obo/HP_0003831	Typified by age-related disease onset	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Description of conditions in which age of onset is typically later in life and in which penetrance is dependent on the age of the subject.
http://purl.obolibrary.org/obo/HP_0003834	Shoulder dislocation	http://purl.obolibrary.org/obo/HP_0030310	Upper extremity joint dislocation		A displacement or misalignment of the humerus with respect to the other bones of the should joint. Note that a subluxation is a partial dislocation.
http://purl.obolibrary.org/obo/HP_0003835	Shoulder subluxation	http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation		A partial dislocation of the shoulder joint.
http://purl.obolibrary.org/obo/HP_0003837	Soft-tissue ossification around the shoulders	http://purl.obolibrary.org/obo/HP_0011986	Ectopic ossification		Formation of calcified tissue in the soft tissues surrounding the shoulder.
http://purl.obolibrary.org/obo/HP_0003840	Delayed upper limb epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0003839	Abnormal upper limb epiphysis morphology		A delay in the process of formation and maturation of the epiphysis of one or more long bones of the upper limbs.
http://purl.obolibrary.org/obo/HP_0003849	Flared upper limb metaphysis	http://purl.obolibrary.org/obo/HP_0003856	Upper limb metaphyseal widening		The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the arm.
http://purl.obolibrary.org/obo/HP_0003856	Upper limb metaphyseal widening	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		Increased width (breadth) of metaphyses of the arms.
http://purl.obolibrary.org/obo/HP_0003860	Diaphyseal sclerosis of the upper limbs	http://purl.obolibrary.org/obo/HP_0009808	Anomaly of the upper limb diaphyses		An elevation in bone density in one or more diaphyses of the arms. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0003862	Absent humerus	http://purl.obolibrary.org/obo/HP_0006507	Aplasia/hypoplasia of the humerus		Missing humerus bone associated with congenital failure of development.
http://purl.obolibrary.org/obo/HP_0003864	Bifid humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		Clefting affecting the humerus.
http://purl.obolibrary.org/obo/HP_0003865	Bowed humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		A bending or abnormal curvature of the humerus.
http://purl.obolibrary.org/obo/HP_0003872	Humeral exostoses	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		Presence of more than one exostosis originating in one or both humerus bones. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.
http://purl.obolibrary.org/obo/HP_0003875	Humeral lytic defects	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		Destruction of an area of humerus bone due to a disease process, such as cancer.
http://purl.obolibrary.org/obo/HP_0003882	Slender humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		Reduction in diameter of the humerus.
http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		An anomaly of the humeral epiphysis.
http://purl.obolibrary.org/obo/HP_0003892	Absent humeral epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0012791	Abnormal humeral ossification		Lack of formation of bone in the epiphysis of the humerus.
http://purl.obolibrary.org/obo/HP_0003893	Advanced ossification of the humeral epiphysis	http://purl.obolibrary.org/obo/HP_0010656	Abnormal epiphyseal ossification		Ossification of the humeral epiphysis at an earlier age than normal.
http://purl.obolibrary.org/obo/HP_0003894	Delayed humeral epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		A delay in the process of formation and maturation of the humeral epiphysis.
http://purl.obolibrary.org/obo/HP_0003902	Epiphyseal stippling of the humerus	http://purl.obolibrary.org/obo/HP_0010655	Epiphyseal stippling		The presence of abnormal punctate (speckled, dot-like) calcifications in the humeral epiphysis.
http://purl.obolibrary.org/obo/HP_0003903	Broad humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003904	Wide epiphyses of the upper limbs		Increased width of the humeral epiphysis.
http://purl.obolibrary.org/obo/HP_0003906	Broad humeral epiphyseal plate	http://purl.obolibrary.org/obo/HP_0003905	Abnormality of the humeral epiphyseal plate		Increased width of the humeral epiphyseal growth plate.
http://purl.obolibrary.org/obo/HP_0003908	Corner fracture of metaphysis	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Fracture or fragmentation at the lateral portion of the metaphysis of a long bone. The radiographic appearance is that of a small corner of metaphysis separated from the metaphyseal edge by thin linear radiolucency. This feature can be observed in child abuse but fragmented appearance of the metaphysis or facture-like lesions can also be detected in the setting of certain skeletal dysplasias.
http://purl.obolibrary.org/obo/HP_0003911	Flared humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		Flaring (increase of width with a splayed appearance) of the humeral metaphysis.
http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		An anomaly of the humeral diaphysis.
http://purl.obolibrary.org/obo/HP_0003927	Cortical irregularity of humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		An abnormal irregularity of the cortical surface of the diaphysis (shaft) of the humerus.
http://purl.obolibrary.org/obo/HP_0003935	Wide humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		Increased width of the humeral diaphysis.
http://purl.obolibrary.org/obo/HP_0003939	Humeroulnar synostosis	http://purl.obolibrary.org/obo/HP_0100745	Abnormality of the humeroulnar joint		An abnormal osseous union (fusion) between the ulna and the humerus.
http://purl.obolibrary.org/obo/HP_0003947	Delayed elbow epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0003946	Abnormal elbow epiphysis morphology		A delay in the process of formation and maturation of the epiphysis of one or more long bones that are part of the elbow.
http://purl.obolibrary.org/obo/HP_0003951	Distal humeral metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0003949	Abnormal elbow metaphysis morphology		Irregularity of the normally smooth surface of the metaphysis at the distal end of the humerus (at the elbow).
http://purl.obolibrary.org/obo/HP_0003953	Absent forearm bone	http://purl.obolibrary.org/obo/HP_0006503	Aplasia/hypoplasia involving forearm bones		Absence of one or more forearm bones associated with congenital failure of development.
http://purl.obolibrary.org/obo/HP_0003955	Bone-in-a-bone appearance of forearm	http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology		A descriptive term for a forearm bone that appears to have an additional bone within it on radiography.
http://purl.obolibrary.org/obo/HP_0003956	Bowed forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		A bending or abnormal curvature affecting either the radius, the ulna, or both.
http://purl.obolibrary.org/obo/HP_0004259	Abnormal hamate bone morphology	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		A structural anomaly of the hamate bone, which is the ulnar-most bone located within the distal row of carpal bones, neighboured by the capitate bone radially.
http://purl.obolibrary.org/obo/HP_0004262	Abnormal capitate bone morphology	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		A structural anomaly of the capitate bone, which is the largest of the carpal bones in the human hand.
http://purl.obolibrary.org/obo/HP_0004295	Abnormal gastric mucosa morphology	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		An abnormality of the gastric mucous membrane.
http://purl.obolibrary.org/obo/HP_0004297	Abnormality of the biliary system	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the liver		An abnormality of the biliary system.
http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		The presence of any abnormality affecting the abdominal wall.
http://purl.obolibrary.org/obo/HP_0004299	Hernia of the abdominal wall	http://purl.obolibrary.org/obo/HP_0100790	Hernia		The presence of a hernia in the abdominal wall.
http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Any abnormality of the skeletal muscle cell. Muscle fibers are subdivided into two types. Type I fibers are fatigue-resistant and rich in oxidative enzymes (they stain light with the myosin ATPase reaction), and type II fibers are fast-contracting, fatigue-prone, and rich in glycolytic enzymes (these fibers stain darkly). Normal muscle tissue has a random distribution of type I and type II fibers.
http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Involuntary contractions of muscle leading to involuntary movements of extremities, neck, trunk, or face.
http://purl.obolibrary.org/obo/HP_0004306	Abnormal endocardium morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		An abnormality of the endocardium.
http://purl.obolibrary.org/obo/HP_0004307	Abnormal anatomic location of the heart	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Developmental defect characterized by an anomalous anatomic location of the heart.
http://purl.obolibrary.org/obo/HP_0004309	Ventricular preexcitation	http://purl.obolibrary.org/obo/HP_0004308	Ventricular arrhythmia		An abnormality in which the cardiac ventricles depolarize too early as a result of an abnormality of cardiac conduction pathways such as an accessory pathway.
http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology	http://purl.obolibrary.org/obo/HP_0010974	Abnormal myeloid leukocyte morphology		An abnormality of macrophages.
http://purl.obolibrary.org/obo/HP_0004312	Abnormal reticulocyte morphology	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		A reticulocyte abnormality.
http://purl.obolibrary.org/obo/HP_0004320	Vaginal fistula	http://purl.obolibrary.org/obo/HP_0100589	Urogenital fistula		The presence of a fistula of the vagina.
http://purl.obolibrary.org/obo/HP_0004321	Bladder fistula	http://purl.obolibrary.org/obo/HP_0100589	Urogenital fistula		The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin.
http://purl.obolibrary.org/obo/HP_0004323	Abnormality of body weight	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		An abnormal increase or decrease of weight or an abnormal distribution of mass in the body.
http://purl.obolibrary.org/obo/HP_0004324	Increased body weight	http://purl.obolibrary.org/obo/HP_0004323	Abnormality of body weight		Abnormally increased body weight.
http://purl.obolibrary.org/obo/HP_0004325	Decreased body weight	http://purl.obolibrary.org/obo/HP_0004323	Abnormality of body weight		Abnormally low body weight.
http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology	http://purl.obolibrary.org/obo/HP_0004329	Abnormal posterior eye segment morphology		Any structural anomaly of the vitreous body.
http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humor: the cornea, iris, ciliary body, and lens).
http://purl.obolibrary.org/obo/HP_0004330	Increased skull ossification	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		An increase in the magnitude or amount of ossification of the skull.
http://purl.obolibrary.org/obo/HP_0004332	Abnormal lymphocyte morphology	http://purl.obolibrary.org/obo/HP_0001881	Abnormal leukocyte morphology		An abnormality of lymphocytes.
http://purl.obolibrary.org/obo/HP_0004334	Dermal atrophy	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		Partial or complete wasting (atrophy) of the skin.
http://purl.obolibrary.org/obo/HP_0004337	Abnormality of amino acid metabolism	http://purl.obolibrary.org/obo/HP_0032245	Abnormal metabolism		Abnormality of an amino acid metabolic process.
http://purl.obolibrary.org/obo/HP_0004339	Abnormal circulating sulfur-containing amino acid concentration	http://purl.obolibrary.org/obo/HP_0033107	Abnormal circulating proteinogenic amino acid concentration		Any deviation from the normal concentration of sulfur-containing amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004341	Abnormal vitamin B12 concentration	http://purl.obolibrary.org/obo/HP_0004340	Abnormal circulating vitamin B concentration		The concentration of vitamin B12 (or one of its metabolites) in the blood circulation is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0004345	Ganglioside accumulation	http://purl.obolibrary.org/obo/HP_0004343	Abnormal glycosphingolipid metabolism		Defects in the lysosomal glycosidases or specific co-activators, result in accumulation of the substrates, such as glycosphingolipids, including gangliosides in GM1 gangliosidosis (Tay-Sachs disease) and GM2 gangliosidosis (Sandhoff disease).
http://purl.obolibrary.org/obo/HP_0004347	Weakness of muscles of respiration	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Reduced function of the muscles required to generate subatmospheric pressure in the thoracic cavity during breathing: the diaphragm, the external intercostal and the interchondral part of the internal intercostal muscles.
http://purl.obolibrary.org/obo/HP_0004349	Reduced bone mineral density	http://purl.obolibrary.org/obo/HP_0004348	Abnormality of bone mineral density		A reduction of bone mineral density, that is, of the amount of matter per cubic centimeter of bones.
http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration	http://purl.obolibrary.org/obo/HP_0010932	Abnormal circulating nucleobase concentration		Any deviation from the normal concentration of a pyrimidine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		Any deviation from the normal concentration of carboxylic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004357	Abnormal circulating leucine concentration	http://purl.obolibrary.org/obo/HP_0010892	Abnormal circulating branched chain amino acid concentration		Any deviation from the normal concentration of leucine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		Any deviation from the normal concentration of fatty acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH.
http://purl.obolibrary.org/obo/HP_0004361	Abnormal circulating leptin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An abnormal concentration of leptin in the blood.
http://purl.obolibrary.org/obo/HP_0004362	Abnormal enteric ganglion morphology	http://purl.obolibrary.org/obo/HP_0025028	Abnormal enteric nervous system morphology		An abnormality of the enteric nervous system, which comprises two types of ganglia, the myenteric (Auerbach's) and submucosal (Meissner's) plexuses. The enteric nervous system functions to control gut movement, fluid exchange between the gut and its lumen, and local blood flow.
http://purl.obolibrary.org/obo/HP_0004363	Abnormal circulating calcium concentration	http://purl.obolibrary.org/obo/HP_0010927	Abnormal circulating inorganic divalent cation concentration		Any deviation from the normal concentration of calcium in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		Any deviation from the normal concentration of nitrogen compound in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004365	Abnormal circulating tryptophan concentration	http://purl.obolibrary.org/obo/HP_0004338	Abnormal circulating aromatic amino acid concentration		Any deviation from the normal concentration of tryptophan in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004368	Elevated circulating purine concentration	http://purl.obolibrary.org/obo/HP_0004352	Abnormal circulating purines concentration		The concentration of purines in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0004369	Decreased circulating purines concentration	http://purl.obolibrary.org/obo/HP_0004352	Abnormal circulating purines concentration		The concentration of purines in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		An abnormality of temperature homeostasis.
http://purl.obolibrary.org/obo/HP_0004371	Abnormality of glycosaminoglycan metabolism	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		Abnormality of glycosaminoglycan metabolism.
http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		Abnormally diminished level of attention, responsiveness, or wakefulness.
http://purl.obolibrary.org/obo/HP_0004373	Focal dystonia	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		A type of dystonia that is localized to a specific part of the body.
http://purl.obolibrary.org/obo/HP_0004374	Hemiplegia/hemiparesis	http://purl.obolibrary.org/obo/HP_0010549	Weakness due to upper motor neuron dysfunction		Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a severe or complete loss of strength, whereas hemiparesis refers to a relatively mild loss of strength.
http://purl.obolibrary.org/obo/HP_0004376	Neuroblastic tumor	http://purl.obolibrary.org/obo/HP_0100836	Malignant neoplasm of the central nervous system		A family of tumors arising in the embryonal remnants of the sympathetic nervous system, which includes neuroblastoma, ganglioneuroblastoma, and ganglioneuroma.
http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue).
http://purl.obolibrary.org/obo/HP_0004378	Abnormality of the anus	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		Abnormality of the anal canal.
http://purl.obolibrary.org/obo/HP_0004379	Abnormality of alkaline phosphatase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormality of alkaline phosphatase level.
http://purl.obolibrary.org/obo/HP_0004386	Gastrointestinal inflammation	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of the alimentary part of the gastrointestinal system.
http://purl.obolibrary.org/obo/HP_0004397	Ectopic anus	http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology		Abnormal displacement or malposition of the anus.
http://purl.obolibrary.org/obo/HP_0004398	Peptic ulcer	http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer		The term peptic ulcer refers to acid peptic injury of the digestive tract, resulting in mucosal break reaching the submucosa. Peptic ulcers are usually located in the stomach or proximal duodenum, but they can also be found in the esophagus or Meckel's diverticulum. Infection with Helicobacter pylori and the use of non steroidal antiinflammatory drugs (NSAIDs) or aspirin are the main risk factors of both gastric and duodenal peptic ulcers.
http://purl.obolibrary.org/obo/HP_0004400	Abnormality of the pylorus	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		An abnormality of the pylorus.
http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		An abnormality of the nipple.
http://purl.obolibrary.org/obo/HP_0004408	Abnormality of the sense of smell	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An anomaly in the ability to perceive and distinguish scents (odors).
http://purl.obolibrary.org/obo/HP_0004418	Thrombophlebitis	http://purl.obolibrary.org/obo/HP_0004936	Venous thrombosis		Inflammation of a vein associated with venous thrombosis (blood clot formation within the vein).
http://purl.obolibrary.org/obo/HP_0004420	Arterial thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		The formation of a blood clot inside an artery.
http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology	http://purl.obolibrary.org/obo/HP_0000309	Abnormal midface morphology		An abnormality of the cheek- one of two bilateral soft tissue facial structures in the region of the face inferior to the eyes and between the nose and the ear. "Buccal" means relating to the cheek. The cheek is part of the midface
http://purl.obolibrary.org/obo/HP_0004429	Recurrent viral infections	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		Increased susceptibility to viral infections as manifested by recurrent episodes of viral infection.
http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		The presence of abnormally shaped erythrocytes.
http://purl.obolibrary.org/obo/HP_0004586	Biconcave vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward.
http://purl.obolibrary.org/obo/HP_0004673	Decreased facial expression	http://purl.obolibrary.org/obo/HP_0005346	Abnormal facial expression		A reduced degree of voluntary and involuntary facial movements involved in responded to others or expressing emotions.
http://purl.obolibrary.org/obo/HP_0004742	Abnormal renal collecting system morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An abnormality of the renal collecting system.
http://purl.obolibrary.org/obo/HP_0004755	Supraventricular tachycardia	http://purl.obolibrary.org/obo/HP_0005115	Supraventricular arrhythmia		Supraventricular tachycardia (SVT) is an abnormally increased heart rate (over 100 beats per minute at rest) with origin above the level of the ventricles.
http://purl.obolibrary.org/obo/HP_0004890	Elevated pulmonary artery pressure	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		An abnormally elevated blood pressure in the circulation of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004921	Abnormal circulating magnesium concentration	http://purl.obolibrary.org/obo/HP_0010927	Abnormal circulating inorganic divalent cation concentration		Any deviation from the normal concentration of magnesium in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004934	Vascular calcification	http://purl.obolibrary.org/obo/HP_0011915	Cardiovascular calcification		Abnormal calcification of the vasculature.
http://purl.obolibrary.org/obo/HP_0004936	Venous thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow.
http://purl.obolibrary.org/obo/HP_0004947	Arteriovenous fistula	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		An abnormal connection between an artery and vein.
http://purl.obolibrary.org/obo/HP_0005003	Aplasia/Hypoplasia of the capital femoral epiphysis	http://purl.obolibrary.org/obo/HP_0010577	Absent epiphyses		Absence or underdevelopment of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0005054	Metaphyseal spurs	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Bony outgrowths that extend laterally from the margin of the metaphysis.
http://purl.obolibrary.org/obo/HP_0005089	Abnormal metaphyseal trabeculation	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		An abnormality of the pattern of trabecula (small interconnecting rods of bone) in a metaphyseal region of bone.
http://purl.obolibrary.org/obo/HP_0005106	Abnormality of the vertebral endplates	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Any abnormality of the vertebral end plates, which are the top and bottom portions of the vertebral bodies that interface with the vertebral disks.
http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		An abnormality of the sacral bone.
http://purl.obolibrary.org/obo/HP_0005108	Abnormal intervertebral disk morphology	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Any structural abnormality of the intervertebral disk.
http://purl.obolibrary.org/obo/HP_0005109	Abnormal Achilles tendon morphology	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		An abnormality of the Achilles tendon.
http://purl.obolibrary.org/obo/HP_0005116	Arterial tortuosity	http://purl.obolibrary.org/obo/HP_0004948	Vascular tortuosity		Abnormal tortuous (i.e., twisted) form of arteries.
http://purl.obolibrary.org/obo/HP_0005120	Abnormal cardiac atrium morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Any structural abnormality of a cardiac atrium.
http://purl.obolibrary.org/obo/HP_0005132	Pericardial constriction	http://purl.obolibrary.org/obo/HP_0001697	Abnormal pericardium morphology		Compression of the heart caused by rigid, thickened, or fused pericardial membranes.
http://purl.obolibrary.org/obo/HP_0005150	Abnormal atrioventricular conduction	http://purl.obolibrary.org/obo/HP_0031546	Cardiac conduction abnormality		An impairment of the electrical continuity between the atria and ventricles.
http://purl.obolibrary.org/obo/HP_0005214	Intestinal obstruction	http://purl.obolibrary.org/obo/HP_0004796	Gastrointestinal obstruction		Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal.
http://purl.obolibrary.org/obo/HP_0005222	Bowel diverticulosis	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		The presence of multiple diverticula of the intestine.
http://purl.obolibrary.org/obo/HP_0005231	Chronic gastritis	http://purl.obolibrary.org/obo/HP_0005263	Gastritis		A chronic form of gastritis.
http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Abnormality of the nostril.
http://purl.obolibrary.org/obo/HP_0005306	Capillary hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		The presence of a capillary hemangioma, which are hemangiomas with small endothelial spaces.
http://purl.obolibrary.org/obo/HP_0005324	Disturbance of facial expression	http://purl.obolibrary.org/obo/HP_0005346	Abnormal facial expression		An abnormality of the gestures or movements executed with the facial muscles with which emotions such as fear, joy, sadness, surprise, and disgust can be expressed.
http://purl.obolibrary.org/obo/HP_0005372	Abnormal B cell physiology	http://purl.obolibrary.org/obo/HP_0031409	Abnormal lymphocyte physiology		An abnormality of the physiological functioning of B cells.
http://purl.obolibrary.org/obo/HP_0005406	Recurrent bacterial skin infections	http://purl.obolibrary.org/obo/HP_0002718	Recurrent bacterial infections		Increased susceptibility to bacterial infections of the skin, as manifested by recurrent episodes of infectious dermatitis.
http://purl.obolibrary.org/obo/HP_0005420	Recurrent gram-negative bacterial infections	http://purl.obolibrary.org/obo/HP_0002718	Recurrent bacterial infections		Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents.
http://purl.obolibrary.org/obo/HP_0005445	Enlarged posterior fossa	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		Abnormal increased size of the posterior cranial fossa.
http://purl.obolibrary.org/obo/HP_0005453	Absent/hypoplastic paranasal sinuses	http://purl.obolibrary.org/obo/HP_0009120	Aplasia/Hypoplasia involving the sinuses		Aplasia or hypoplasia of the paranasal sinuses.
http://purl.obolibrary.org/obo/HP_0005557	Abnormal zygomatic arch morphology	http://purl.obolibrary.org/obo/HP_0010668	Abnormal zygomatic bone morphology		An abnormality of the zygomatic arch, also known as the cheek bone.
http://purl.obolibrary.org/obo/HP_0005613	Aplasia/hypoplasia of the femur	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		Absence or underdevelopment of the femur.
http://purl.obolibrary.org/obo/HP_0005616	Accelerated skeletal maturation	http://purl.obolibrary.org/obo/HP_0000927	Abnormality of skeletal maturation		An abnormally increased rate of skeletal maturation. Accelerated skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.
http://purl.obolibrary.org/obo/HP_0005619	Thoracolumbar kyphosis	http://purl.obolibrary.org/obo/HP_0100712	Abnormal lumbar spine morphology		Hyperconvexity of the thoracolumbar spine producing a rounded or humped appearance.
http://purl.obolibrary.org/obo/HP_0005656	Positional foot deformity	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		A foot deformity resulting due to an abnormality affecting the muscle and soft tissue. In contrast if the bones of the foot are affected the term structural foot deformity applies.
http://purl.obolibrary.org/obo/HP_0005731	Cortical irregularity	http://purl.obolibrary.org/obo/HP_0003103	Abnormal cortical bone morphology		An abnormal irregularity of cortical bone.
http://purl.obolibrary.org/obo/HP_0005750	Lower-limb joint contracture	http://purl.obolibrary.org/obo/HP_0003121	Limb joint contracture		A limitation in the passive range of motion of a joint of the lower limb resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin.
http://purl.obolibrary.org/obo/HP_0005815	Supernumerary ribs	http://purl.obolibrary.org/obo/HP_0009144	Supernumerary bones of the axial skeleton		The presence of more than 12 rib pairs.
http://purl.obolibrary.org/obo/HP_0005905	Abnormal cervical curvature	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		The presence of an abnormal curvature of the cervical vertebral column.
http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology	http://purl.obolibrary.org/obo/HP_0040070	Abnormal upper limb bone morphology		Any abnormal shape or structure of the metacarpal bones.
http://purl.obolibrary.org/obo/HP_0005917	Supernumerary metacarpal bones	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		The presence of more than the normal number of metacarpal bones.
http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology	http://purl.obolibrary.org/obo/HP_0001155	Abnormality of the hand		Any structural anomaly of the hand.
http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		An anomaly of epiphysis, which is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk.
http://purl.obolibrary.org/obo/HP_0006000	Ureteral obstruction	http://purl.obolibrary.org/obo/HP_0025634	Abnormal ureter physiology		Obstruction of the flow of urine through the ureter.
http://purl.obolibrary.org/obo/HP_0006101	Finger syndactyly	http://purl.obolibrary.org/obo/HP_0001159	Syndactyly		Webbing or fusion of the fingers, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are referred to as "Symphalangism".
http://purl.obolibrary.org/obo/HP_0006109	Absent phalangeal crease	http://purl.obolibrary.org/obo/HP_0006143	Abnormal finger flexion crease		Absence of one or more interphalangeal creases (i.e., of the transverse lines in the skin between the phalanges of the fingers).
http://purl.obolibrary.org/obo/HP_0006119	Proximal tapering of metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Some or all of the metacarpal bones (i.e., metacarpal II to V) have a pointed proximal appearance.
http://purl.obolibrary.org/obo/HP_0006143	Abnormal finger flexion crease	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Anomalous flexion crease (i.e., a transverse line that crosses the skin of a finger).
http://purl.obolibrary.org/obo/HP_0006288	Advanced eruption of teeth	http://purl.obolibrary.org/obo/HP_0006292	Abnormality of dental eruption		Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age.
http://purl.obolibrary.org/obo/HP_0006292	Abnormality of dental eruption	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		An abnormality of tooth eruption.
http://purl.obolibrary.org/obo/HP_0006392	Increased density of long bones	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		An abnormal increase in the bone density of the long bones.
http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		Any abnormality of the alveolar ridges (on the upper or lower jaws). The alveolar ridges contain the sockets (alveoli) of the teeth.
http://purl.obolibrary.org/obo/HP_0006479	Abnormal dental pulp morphology	http://purl.obolibrary.org/obo/HP_0011061	Abnormality of dental structure		An abnormality of the dental pulp.
http://purl.obolibrary.org/obo/HP_0006481	Abnormal primary tooth morphology	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		Any abnormality of the primary tooth.
http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		An abnormality of the morphology of the tooth.
http://purl.obolibrary.org/obo/HP_0006485	Agenesis of incisor	http://purl.obolibrary.org/obo/HP_0011064	Abnormal number of incisors		Agenesis of incisor.
http://purl.obolibrary.org/obo/HP_0006486	Abnormal dental root morphology	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		An abnormality of the dental root.
http://purl.obolibrary.org/obo/HP_0006487	Bowing of the long bones	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		A bending or abnormal curvature of a long bone.
http://purl.obolibrary.org/obo/HP_0006488	Bowing of the arm	http://purl.obolibrary.org/obo/HP_0006487	Bowing of the long bones		A bending or abnormal curvature affecting a long bone of the arm.
http://purl.obolibrary.org/obo/HP_0006489	Abnormal femoral metaphysis morphology	http://purl.obolibrary.org/obo/HP_0006490	Abnormal lower-limb metaphysis morphology		An anomaly of the femoral metaphysis.
http://purl.obolibrary.org/obo/HP_0006492	Aplasia/Hypoplasia of the fibula	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		Absence or underdevelopment of the fibula.
http://purl.obolibrary.org/obo/HP_0006495	Aplasia/Hypoplasia of the ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Absence or underdevelopment of the ulna.
http://purl.obolibrary.org/obo/HP_0006498	Aplasia/Hypoplasia of the patella	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		Absence or underdevelopment of the patella.
http://purl.obolibrary.org/obo/HP_0006501	Aplasia/Hypoplasia of the radius	http://purl.obolibrary.org/obo/HP_0006503	Aplasia/hypoplasia involving forearm bones		A small/hypoplastic or absent/aplastic radius.
http://purl.obolibrary.org/obo/HP_0006502	Aplasia/Hypoplasia involving the carpal bones	http://purl.obolibrary.org/obo/HP_0005927	Aplasia/hypoplasia involving bones of the hand		Absence or underdevelopment of the carpal bones.
http://purl.obolibrary.org/obo/HP_0006505	Abnormal limb epiphysis morphology	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		An anomaly of one or more epiphyses of a limb.
http://purl.obolibrary.org/obo/HP_0006507	Aplasia/hypoplasia of the humerus	http://purl.obolibrary.org/obo/HP_0006496	Aplasia/hypoplasia involving bones of the upper limbs		Absence (due to failure to form) or underdevelopment of the humerus.
http://purl.obolibrary.org/obo/HP_0006685	Endocardial fibrosis	http://purl.obolibrary.org/obo/HP_0004306	Abnormal endocardium morphology		The presence of excessive connective tissue in the endocardium.
http://purl.obolibrary.org/obo/HP_0006695	Atrioventricular canal defect	http://purl.obolibrary.org/obo/HP_0001671	Abnormal cardiac septum morphology		A defect of the atrioventricular septum of the heart.
http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any structural abnormality of the coronary arteries.
http://purl.obolibrary.org/obo/HP_0006705	Abnormal atrioventricular valve morphology	http://purl.obolibrary.org/obo/HP_0001654	Abnormal heart valve morphology		An abnormality of an atrioventricular valve.
http://purl.obolibrary.org/obo/HP_0006707	Abnormality of the hepatic vasculature	http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the vasculature		An abnormality of the hepatic vasculature.
http://purl.obolibrary.org/obo/HP_0006710	Aplasia/Hypoplasia of the clavicles	http://purl.obolibrary.org/obo/HP_0006711	Aplasia/Hypoplasia involving bones of the thorax		Absence or underdevelopment of the clavicles (collar bones).
http://purl.obolibrary.org/obo/HP_0006802	Abnormal anterior horn cell morphology	http://purl.obolibrary.org/obo/HP_0002450	Abnormal motor neuron morphology		Any anomaly of the anterior horn cell.
http://purl.obolibrary.org/obo/HP_0006817	Aplasia/Hypoplasia of the cerebellar vermis	http://purl.obolibrary.org/obo/HP_0007360	Aplasia/Hypoplasia of the cerebellum		Absence or underdevelopment of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0006872	Cerebral hypoplasia	http://purl.obolibrary.org/obo/HP_0007364	Aplasia/Hypoplasia of the cerebrum		Underdevelopment of the cerebrum.
http://purl.obolibrary.org/obo/HP_0006989	Dysplastic corpus callosum	http://purl.obolibrary.org/obo/HP_0001273	Abnormal corpus callosum morphology		Dysplasia and dysgenesis of the corpus callosum are nonspecific descriptions that imply defective development of the corpus callosum. The term dysplasia is applied when the morphology of the corpus callosum is altered as a congenital trait. For instance, the corpus callosum may be hump-shaped, kinked, or a striped corpus callosum that lacks an anatomically distinct genu and splenium.
http://purl.obolibrary.org/obo/HP_0007181	Interosseus muscle atrophy	http://purl.obolibrary.org/obo/HP_0003693	Distal amyotrophy		Atrophy of the interosseus muscles (including the palmar interossei that lie on the anterior aspect of the metacarpals, the dorsal interosseus muscles of the hand, which lie between the intercarpals, the plantar interosseus muscles, which lie underneath the metatarsal bones, and the dorsal interossei, which are located between the metatarsal bones.
http://purl.obolibrary.org/obo/HP_0007256	Abnormal pyramidal sign	http://purl.obolibrary.org/obo/HP_0002493	Upper motor neuron dysfunction		Functional neurological abnormalities related to dysfunction of the pyramidal tract.
http://purl.obolibrary.org/obo/HP_0007291	Posterior fossa cyst	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		A discrete posterior fossa cerebrospinal fluid (CSF) collection that does not communicate directly with the fourth ventricle.
http://purl.obolibrary.org/obo/HP_0007305	CNS demyelination	http://purl.obolibrary.org/obo/HP_0011400	Abnormal CNS myelination		A loss of myelin from nerve fibers in the central nervous system.
http://purl.obolibrary.org/obo/HP_0007359	Focal-onset seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures.
http://purl.obolibrary.org/obo/HP_0007369	Atrophy/Degeneration affecting the cerebrum	http://purl.obolibrary.org/obo/HP_0012444	Brain atrophy		The presence of atrophy (wasting) of the cerebrum, also known as the telencephalon, the largest and most highly developed part of the human brain.
http://purl.obolibrary.org/obo/HP_0007370	Aplasia/Hypoplasia of the corpus callosum	http://purl.obolibrary.org/obo/HP_0033725	Thin corpus callosum		Absence or underdevelopment of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0007373	Motor neuron atrophy	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		Wasting involving the motor neuron.
http://purl.obolibrary.org/obo/HP_0007375	Abnormal septum pellucidum morphology	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		An abnormality of the septum pellucidum, which is a thin, triangular, vertical membrane separating the lateral ventricles of the brain.
http://purl.obolibrary.org/obo/HP_0007376	Abnormal choroid plexus morphology	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		An abnormality of the choroid plexus, which is the area in the cerebral ventricles in which cerebrospinal fluid is produced by modified ependymal cells.
http://purl.obolibrary.org/obo/HP_0007377	Abnormality of somatosensory evoked potentials	http://purl.obolibrary.org/obo/HP_0430106	Abnormal brain-evoked potentials		An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex.
http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract	http://purl.obolibrary.org/obo/HP_0034930	Digestive system neoplasm		A tumor (abnormal growth of tissue) of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0007460	Autoamputation of digits	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		The spontaneous detachment of a digit (finger or toe) from the body due to long standing pathology.
http://purl.obolibrary.org/obo/HP_0007477	Abnormal dermatoglyphics	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		An abnormality of dermatoglyphs (fingerprints), which are present on fingers, palms, toes, and soles.
http://purl.obolibrary.org/obo/HP_0007499	Recurrent staphylococcal infections	http://purl.obolibrary.org/obo/HP_0002718	Recurrent bacterial infections		Increased susceptibility to staphylococcal infections as manifested by recurrent episodes of staphylococcal infections.
http://purl.obolibrary.org/obo/HP_0007556	Plantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		Hyperkeratosis affecting the sole of the foot.
http://purl.obolibrary.org/obo/HP_0007641	Dyschromatopsia	http://purl.obolibrary.org/obo/HP_0000551	Color vision defect		A form of colorblindness in which only two of the three fundamental colors can be distinguished due to a lack of one of the retinal cone pigments.
http://purl.obolibrary.org/obo/HP_0007676	Hypoplasia of the iris	http://purl.obolibrary.org/obo/HP_0008053	Aplasia/Hypoplasia of the iris		Congenital underdevelopment of the iris.
http://purl.obolibrary.org/obo/HP_0007700	Ocular anterior segment dysgenesis	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin.
http://purl.obolibrary.org/obo/HP_0007703	Abnormal retinal pigmentation	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Any deviation from the normal pigmentation of the retina.
http://purl.obolibrary.org/obo/HP_0007730	Iris hypopigmentation	http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation		An abnormal reduction in the amount of pigmentation of the iris.
http://purl.obolibrary.org/obo/HP_0007759	Opacification of the corneal stroma	http://purl.obolibrary.org/obo/HP_0011492	Abnormal corneal stroma morphology		Reduced transparency of the stroma of cornea.
http://purl.obolibrary.org/obo/HP_0007772	Impaired smooth pursuit	http://purl.obolibrary.org/obo/HP_0000617	Abnormality of ocular smooth pursuit		An impairment of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion.
http://purl.obolibrary.org/obo/HP_0007858	Chorioretinal lacunae	http://purl.obolibrary.org/obo/HP_0000532	Abnormal chorioretinal morphology		Punched out lesions in the pigmented layer of the retina.
http://purl.obolibrary.org/obo/HP_0007957	Corneal opacity	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		A reduction of corneal clarity.
http://purl.obolibrary.org/obo/HP_0008011	Peripheral opacification of the cornea	http://purl.obolibrary.org/obo/HP_0007759	Opacification of the corneal stroma		Reduced transparency of the peripheral region of the cornea.
http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		Abnormal pigmentation of the iris.
http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology	http://purl.obolibrary.org/obo/HP_0008047	Abnormality of the vasculature of the eye		A structural abnormality of retinal vasculature.
http://purl.obolibrary.org/obo/HP_0008048	Abnormal line of Schwalbe morphology	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		An abnormality of the line of Schwalbe.
http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		An abnormality of an extraocular muscle.
http://purl.obolibrary.org/obo/HP_0008052	Retinal fold	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		A wrinkle of retinal tissue projecting outward from the surface of the retina and visible as a line on fundoscopy.
http://purl.obolibrary.org/obo/HP_0008053	Aplasia/Hypoplasia of the iris	http://purl.obolibrary.org/obo/HP_0008062	Aplasia/Hypoplasia affecting the anterior segment of the eye		Absence or underdevelopment of the iris.
http://purl.obolibrary.org/obo/HP_0008054	Abnormal morphology of the conjunctival vasculature	http://purl.obolibrary.org/obo/HP_0008047	Abnormality of the vasculature of the eye		Any abnormality of the blood vessels of the conjunctiva.
http://purl.obolibrary.org/obo/HP_0008055	Aplasia/Hypoplasia affecting the uvea	http://purl.obolibrary.org/obo/HP_0008056	Aplasia/Hypoplasia affecting the eye		Absence or underdevelopment of the uvea, the pigmented middle layer of the eye consisting of the iris and ciliary body together with the choroid.
http://purl.obolibrary.org/obo/HP_0008057	Aplasia/Hypoplasia affecting the fundus	http://purl.obolibrary.org/obo/HP_0008056	Aplasia/Hypoplasia affecting the eye		A developmental defect characterized by lack of development or underdevelopment of the fundus/fovea.
http://purl.obolibrary.org/obo/HP_0008066	Abnormal blistering of the skin	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls.
http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the skin.
http://purl.obolibrary.org/obo/HP_0008155	Mucopolysacchariduria	http://purl.obolibrary.org/obo/HP_0003541	Urinary glycosaminoglycan excretion		Excessive amounts of mucopolysaccharide in the urine.
http://purl.obolibrary.org/obo/HP_0008364	Abnormality of the calcaneus	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		An abnormality of the calcaneus, also known as the heel bone, one of the or heel bone, one of the components of the tarsus of the foot which make up the heel.
http://purl.obolibrary.org/obo/HP_0008365	Abnormal talus morphology	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		An abnormality of the talus.
http://purl.obolibrary.org/obo/HP_0008366	Foot joint contracture	http://purl.obolibrary.org/obo/HP_0005750	Lower-limb joint contracture		Contractures of one or more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0008386	Aplasia/Hypoplasia of the nails	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Aplasia or developmental hypoplasia of the nail.
http://purl.obolibrary.org/obo/HP_0008388	Abnormal toenail morphology	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		An anomaly of the toenail.
http://purl.obolibrary.org/obo/HP_0008404	Nail dystrophy	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate.
http://purl.obolibrary.org/obo/HP_0008428	Vertebral clefting	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Schisis (cleft or cleavage) of vertebral bodies.
http://purl.obolibrary.org/obo/HP_0008440	C1-C2 vertebral abnormality	http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine		Any abnormality of the atlas and the axis.
http://purl.obolibrary.org/obo/HP_0008519	Abnormal coccyx morphology	http://purl.obolibrary.org/obo/HP_0002644	Abnormal pelvic girdle bone morphology		Any structural abnormality of the coccyx.
http://purl.obolibrary.org/obo/HP_0008544	Abnormally folded helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Any structural anomaly of the border of the helix, which usually forms a rolled rim but is highly variable in shape.
http://purl.obolibrary.org/obo/HP_0008628	Abnormal stapes morphology	http://purl.obolibrary.org/obo/HP_0004452	Abnormality of the middle ear ossicles		An abnormality of the stapes, a stirrup-shaped ossicle in the middle ear.
http://purl.obolibrary.org/obo/HP_0008629	Pulsatile tinnitus	http://purl.obolibrary.org/obo/HP_0000360	Tinnitus		Pulsatile tinnitus is generally classified a kind of objective tinnitus, meaning that it is not only audible to the patient but also to the examiner on auscultation of the auditory canal and/or of surrounding structures with use of an auscultation tube or stethoscope. Usually, pulsatile tinnitus is heard as a lower pitched thumping or booming, a rougher blowing sound which is coincidental with respiration, or as a clicking, higher pitched rhythmic sensation.
http://purl.obolibrary.org/obo/HP_0008669	Abnormal spermatogenesis	http://purl.obolibrary.org/obo/HP_0000025	Functional abnormality of male internal genitalia		Incomplete maturation or aberrant formation of the male gametes.
http://purl.obolibrary.org/obo/HP_0008678	Renal hypoplasia/aplasia	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Absence or underdevelopment of the kidney.
http://purl.obolibrary.org/obo/HP_0008684	Aplasia/hypoplasia of the uterus	http://purl.obolibrary.org/obo/HP_0000130	Abnormality of the uterus		Absence or developmental hypoplasia of the uterus.
http://purl.obolibrary.org/obo/HP_0008775	Abnormal prostate morphology	http://purl.obolibrary.org/obo/HP_0000022	Abnormal male internal genitalia morphology		An abnormality of the prostate.
http://purl.obolibrary.org/obo/HP_0008776	Abnormal renal artery morphology	http://purl.obolibrary.org/obo/HP_0020317	Abnormal abdominal aorta branch artery morphology		Any structural abnormality of the renal artery.
http://purl.obolibrary.org/obo/HP_0008777	Abnormal vocal cord morphology	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		An abnormality of the vocal cord.
http://purl.obolibrary.org/obo/HP_0008800	Limited hip movement	http://purl.obolibrary.org/obo/HP_0001376	Limitation of joint mobility		A decreased ability to move the femur at the hip joint associated with a decreased range of motion of the hip.
http://purl.obolibrary.org/obo/HP_0008872	Feeding difficulties in infancy	http://purl.obolibrary.org/obo/HP_0011968	Feeding difficulties		Impaired feeding performance of an infant as manifested by difficulties such as weak and ineffective sucking, brief bursts of sucking, and falling asleep during sucking. There may be difficulties with chewing or maintaining attention.
http://purl.obolibrary.org/obo/HP_0008887	Adipose tissue loss	http://purl.obolibrary.org/obo/HP_0040063	Decreased adipose tissue		A reduction in the amount of adipose tissue (fat) compared with the amount previously present in an individual.
http://purl.obolibrary.org/obo/HP_0008897	Postnatal growth retardation	http://purl.obolibrary.org/obo/HP_0001510	Growth delay		Slow or limited growth after birth.
http://purl.obolibrary.org/obo/HP_0008905	Rhizomelia	http://purl.obolibrary.org/obo/HP_0008873	Disproportionate short-limb short stature		Disproportionate shortening of the proximal segment of limbs (i.e. the femur and humerus).
http://purl.obolibrary.org/obo/HP_0008968	Muscle hypertrophy of the lower extremities	http://purl.obolibrary.org/obo/HP_0003712	Skeletal muscle hypertrophy		Muscle hypertrophy primarily affecting the legs.
http://purl.obolibrary.org/obo/HP_0008988	Pelvic girdle muscle atrophy	http://purl.obolibrary.org/obo/HP_0001471	Aplasia/Hypoplasia of the musculature of the pelvis		Muscular atrophy affecting the muscles that attach to the pelvic girdle (the gluteal muscles, the lateral rotators, adductor magnus, adductor brevis, adductor longus, pectineus, and gracilis muscles).
http://purl.obolibrary.org/obo/HP_0008994	Proximal lower limb muscle weakness	http://purl.obolibrary.org/obo/HP_0003701	Proximal muscle weakness		A lack of strength of the proximal muscles of the legs.
http://purl.obolibrary.org/obo/HP_0009104	Aplasia/Hypoplasia of the pubic bone	http://purl.obolibrary.org/obo/HP_0009103	Aplasia/Hypoplasia involving the pelvis		Absence or underdevelopment of the pubic bone.
http://purl.obolibrary.org/obo/HP_0009117	Aplasia/Hypoplasia of the maxilla	http://purl.obolibrary.org/obo/HP_0009116	Aplasia/Hypoplasia involving bones of the skull		Absence or underdevelopment of the maxilla.
http://purl.obolibrary.org/obo/HP_0009118	Aplasia/Hypoplasia of the mandible	http://purl.obolibrary.org/obo/HP_0009116	Aplasia/Hypoplasia involving bones of the skull		Absence or underdevelopment of the mandible.
http://purl.obolibrary.org/obo/HP_0009119	Aplasia/Hypoplasia of the frontal sinuses	http://purl.obolibrary.org/obo/HP_0009120	Aplasia/Hypoplasia involving the sinuses		Absence or underdevelopment of frontal sinus.
http://purl.obolibrary.org/obo/HP_0009121	Abnormal axial skeleton morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum.
http://purl.obolibrary.org/obo/HP_0009124	Abnormal adipose tissue morphology	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		An abnormality of adipose tissue, which is loose connective tissue composed of adipocytes.
http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		A structural anomaly of the appendicular musculature, comprising muscles of the upper limb and pectoral girdle as well as muscles of the lower limb and pelvic girdle.
http://purl.obolibrary.org/obo/HP_0009130	Hand muscle atrophy	http://purl.obolibrary.org/obo/HP_0007149	Distal upper limb amyotrophy		Muscular atrophy involving the muscles of the hand.
http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology	http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology		Any structural anomaly of a cerebral artery. The cerebral arteries comprise three main pairs of arteries and their branches, which supply the cerebrum of the brain. These are the anterior cerebral artery, the middle cerebral artery, and the posterior cerebral artery.
http://purl.obolibrary.org/obo/HP_0009198	Abnormality of the epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		Abnormality of the epiphysis of the distal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009380	Finger aplasia	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		A developmental defect resulting in the presence of fewer than the normal number of fingers (i.e., aplasia of one or more fingers).
http://purl.obolibrary.org/obo/HP_0009382	Absent epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010228	Absent epiphyses of the phalanges of the hand		Absence of one or more epiphyses of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009466	Radial deviation of finger	http://purl.obolibrary.org/obo/HP_0009485	Radial deviation of the hand or of fingers of the hand		Bending or curvature of a finger toward the radial side (i.e., towards the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.
http://purl.obolibrary.org/obo/HP_0009484	Deviation of the hand or of fingers of the hand	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		Displacement of the hand or of fingers of the hand from their normal position.
http://purl.obolibrary.org/obo/HP_0009553	Abnormality of the hairline	http://purl.obolibrary.org/obo/HP_0011361	Congenital abnormal hair pattern		The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair.
http://purl.obolibrary.org/obo/HP_0009603	Deviation of the thumb	http://purl.obolibrary.org/obo/HP_0004097	Deviation of finger		Displacement of the thumb from its normal position.
http://purl.obolibrary.org/obo/HP_0009617	Abnormality of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009602	Abnormality of thumb phalanx		Any anomaly of the distal phalanx of thumb.
http://purl.obolibrary.org/obo/HP_0009700	Finger symphalangism	http://purl.obolibrary.org/obo/HP_0100262	Synostosis involving digits		An abnormal union between bones or parts of bones of the fingers. The synonymous term "symphalangism of the hand" may be translated as fusions of bones of varying digree, that involve at least one phalangeal bone of the hand. If bony fusions are referred to as "Symphalangism" the fusion occurs in a proximo-distal axis. Fusions of bones of the fingers in a radio-ulnar axis are referred to as "bony" Syndactyly.
http://purl.obolibrary.org/obo/HP_0009702	Carpal synostosis	http://purl.obolibrary.org/obo/HP_0100266	Synostosis of carpals/tarsals		Synostosis (bony fusion) involving one or more bones of the carpus (scaphoid, lunate, triquetrum, trapezium, trapezoid, capitate, hamate, pisiform).
http://purl.obolibrary.org/obo/HP_0009714	Abnormal epididymis morphology	http://purl.obolibrary.org/obo/HP_0000022	Abnormal male internal genitalia morphology		An abnormality of the epididymis.
http://purl.obolibrary.org/obo/HP_0009725	Bladder neoplasm	http://purl.obolibrary.org/obo/HP_0010786	Urinary tract neoplasm		The presence of a neoplasm of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0009728	Neoplasm of striated muscle	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A benign or malignant neoplasm (tumor) originating in striated muscle, either skeletal muscle or cardiac muscle.
http://purl.obolibrary.org/obo/HP_0009731	Cerebral hamartoma	http://purl.obolibrary.org/obo/HP_0100835	Benign neoplasm of the central nervous system		The presence of a hamartoma of the cerebrum.
http://purl.obolibrary.org/obo/HP_0009733	Glioma	http://purl.obolibrary.org/obo/HP_0100836	Malignant neoplasm of the central nervous system		The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes).
http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		An abnormality of the antihelix.
http://purl.obolibrary.org/obo/HP_0009798	Euthyroid goiter	http://purl.obolibrary.org/obo/HP_0000853	Goiter		A goiter that is not associated with functional thyroid abnormalities.
http://purl.obolibrary.org/obo/HP_0009799	Supernumerary spleens	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		The presence of two or more accessory spleens.
http://purl.obolibrary.org/obo/HP_0009804	Tooth agenesis	http://purl.obolibrary.org/obo/HP_0006483	Abnormal number of teeth		The absence of one or more teeth from the normal series by a failure to develop
http://purl.obolibrary.org/obo/HP_0009808	Anomaly of the upper limb diaphyses	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		A structural abnormality of a diaphysis of the arm.
http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		An anomaly of one or more metaphyses of the arms.
http://purl.obolibrary.org/obo/HP_0009811	Abnormality of the elbow	http://purl.obolibrary.org/obo/HP_0009810	Abnormality of upper limb joint		An anomaly of the joint that connects the upper and the lower arm.
http://purl.obolibrary.org/obo/HP_0009821	Forearm undergrowth	http://purl.obolibrary.org/obo/HP_0009824	Upper limb undergrowth		Forearm shortening because of underdevelopment of one or more bones of the forearm.
http://purl.obolibrary.org/obo/HP_0009826	Limb undergrowth	http://purl.obolibrary.org/obo/HP_0009815	Aplasia/hypoplasia of the extremities		Limb shortening because of underdevelopment of one or more bones of the extremities.
http://purl.obolibrary.org/obo/HP_0009827	Amelia	http://purl.obolibrary.org/obo/HP_0009815	Aplasia/hypoplasia of the extremities		Congenital absence (aplasia) of one or more limbs.
http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		Peripheral neuropathy is a general term for any disorder of the peripheral nervous system. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course.
http://purl.obolibrary.org/obo/HP_0009832	Abnormal distal phalanx morphology of finger	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Any anomaly of distal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0009887	Abnormality of hair pigmentation	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		An abnormality of hair pigmentation (color).
http://purl.obolibrary.org/obo/HP_0009890	High anterior hairline	http://purl.obolibrary.org/obo/HP_0000599	Abnormality of the frontal hairline		Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD above the mean. Alternatively, an apparently increased distance between the hairline and the glabella.
http://purl.obolibrary.org/obo/HP_0009906	Aplasia/Hypoplasia of the earlobes	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Absence or underdevelopment of the ear lobes.
http://purl.obolibrary.org/obo/HP_0009924	Aplasia/Hypoplasia involving the nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Underdevelopment or absence of the nose or parts thereof.
http://purl.obolibrary.org/obo/HP_0009929	Abnormal columella morphology	http://purl.obolibrary.org/obo/HP_0010938	Abnormal external nose morphology		A structural abnormality of the columella.
http://purl.obolibrary.org/obo/HP_0009997	Duplication of phalanx of hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0010051	Deviation of the hallux	http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes		Displacement of the big toe from its normal position.
http://purl.obolibrary.org/obo/HP_0010185	Aplasia/Hypoplasia of the distal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		Absence or underdevelopment of the distal phalanges of the toes.
http://purl.obolibrary.org/obo/HP_0010286	Abnormal salivary gland morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		Any abnormality of the salivary glands, the exocrine glands that produce saliva.
http://purl.obolibrary.org/obo/HP_0010295	Aplasia/Hypoplasia of the tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Absence or underdevelopment of the tongue.
http://purl.obolibrary.org/obo/HP_0010299	Abnormal dentin morphology	http://purl.obolibrary.org/obo/HP_0011061	Abnormality of dental structure		Any abnormality of dentin.
http://purl.obolibrary.org/obo/HP_0010301	Spinal dysraphism	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		A heterogeneous group of congenital spinal anomalies that result from defective closure of the neural tube early in fetal life.
http://purl.obolibrary.org/obo/HP_0010311	Aplasia/Hypoplasia of the breasts	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		Absence or underdevelopment of the breasts.
http://purl.obolibrary.org/obo/HP_0010322	Abnormal fifth toe morphology	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		An anomaly of the little toe.
http://purl.obolibrary.org/obo/HP_0010438	Abnormal ventricular septum morphology	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		A structural abnormality of the interventricular septum.
http://purl.obolibrary.org/obo/HP_0010442	Polydactyly	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		A congenital anomaly characterized by the presence of supernumerary fingers or toes.
http://purl.obolibrary.org/obo/HP_0010450	Esophageal stenosis	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		An abnormal narrowing of the lumen of the esophagus.
http://purl.obolibrary.org/obo/HP_0010451	Aplasia/Hypoplasia of the spleen	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Absence or underdevelopment of the spleen.
http://purl.obolibrary.org/obo/HP_0010456	Abnormal greater sciatic notch morphology	http://purl.obolibrary.org/obo/HP_0002644	Abnormal pelvic girdle bone morphology		An abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium.
http://purl.obolibrary.org/obo/HP_0010460	Abnormality of the female genitalia	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		Abnormality of the female genital system.
http://purl.obolibrary.org/obo/HP_0010461	Abnormality of the male genitalia	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		Abnormality of the male genital system.
http://purl.obolibrary.org/obo/HP_0010472	Abnormal circulating porphyrin concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		Any deviation from the normal concentration of porphyrins in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		An abnormality of the creases of the skin of palm of hand.
http://purl.obolibrary.org/obo/HP_0010511	Long toe	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Toes that appear disproportionately long compared to the foot.
http://purl.obolibrary.org/obo/HP_0010514	Hyperpituitarism	http://purl.obolibrary.org/obo/HP_0011747	Abnormality of the anterior pituitary		Hypersecretion of one or more pituitary hormones. This can occur in conditions in which deficiency in the target organ leads to decreased hormonal feedback, or as a primary condition most usually in connection with a pituitary adenoma.
http://purl.obolibrary.org/obo/HP_0010515	Aplasia/Hypoplasia of the thymus	http://purl.obolibrary.org/obo/HP_0000777	Abnormal thymus morphology		Absence or underdevelopment of the thymus.
http://purl.obolibrary.org/obo/HP_0010535	Sleep apnea	http://purl.obolibrary.org/obo/HP_5200283	Sleep-related breathing disorders		An intermittent cessation of airflow at the mouth and nose during sleep is known as sleep apnea. Apneas that last at least 10 seconds are considered significant, but individuals with sleep apnea may experience apneas lasting from 20 seconds up to 2 or 3 minutes. Patients may have up to 15 events per hour of sleep.
http://purl.obolibrary.org/obo/HP_0010546	Muscle fibrillation	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Fine, rapid twitching of individual muscle fibers with little or no movement of the muscle as a whole as ascertained by electromyography (EMG). If a motor neuron or its axon is destroyed, the muscle fibers it innervates undergo denervation atrophy. This leads to hypersensitivity of individual muscle fibers to acetyl choline so that they may contract spontaneously. Isolated activity of individual muscle fibers is generally so fine it cannot be seen through the intact skin, although it can be recorded as a short-duration spike in the EMG.
http://purl.obolibrary.org/obo/HP_0010547	Muscle flaccidity	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		A type of paralysis in which a muscle becomes soft and yields to passive stretching, which results from loss of all or practically all peripheral motor nerves that innervated the muscle. Muscle tone is reduced and the affected muscles undergo extreme atrophy within months of the loss of innervation.
http://purl.obolibrary.org/obo/HP_0010548	Percussion myotonia	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		A localized myotonic contraction in a muscle in reaction to percussion (tapping with the examiner's finger, a rubber percussion hammer, or a similar object).
http://purl.obolibrary.org/obo/HP_0010549	Weakness due to upper motor neuron dysfunction	http://purl.obolibrary.org/obo/HP_0002493	Upper motor neuron dysfunction		Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Paralysis due to lesions of the principle motor tracts is related to a lesion in the corticospinal, corticobulbar or brainstem descending (subcorticospinal) neurons.
http://purl.obolibrary.org/obo/HP_0010550	Paraplegia	http://purl.obolibrary.org/obo/HP_0010551	Paraplegia/paraparesis		Severe or complete weakness of both lower extremities with sparing of the upper extremities.
http://purl.obolibrary.org/obo/HP_0010551	Paraplegia/paraparesis	http://purl.obolibrary.org/obo/HP_0010549	Weakness due to upper motor neuron dysfunction		Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength.
http://purl.obolibrary.org/obo/HP_0010566	Hamartoma	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma.
http://purl.obolibrary.org/obo/HP_0010574	Abnormality of the epiphysis of the femoral head	http://purl.obolibrary.org/obo/HP_0006499	Abnormal femoral epiphysis morphology		Any abnormality of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion	http://purl.obolibrary.org/obo/HP_0030724	Central nervous system cyst		A cystic lesion originating within the brain.
http://purl.obolibrary.org/obo/HP_0010580	Enlarged epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Increased size of epiphyses.
http://purl.obolibrary.org/obo/HP_0010582	Irregular epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		An alteration of the normally smooth contour of the epiphysis leading to an irregular appearance.
http://purl.obolibrary.org/obo/HP_0010585	Small epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Reduction in the size or volume of epiphyses.
http://purl.obolibrary.org/obo/HP_0010606	Hordeolum	http://purl.obolibrary.org/obo/HP_0010732	Nodular changes affecting the eyelids		An acute purulent infection of the sebaceous glands of Zeis at the base of the eyelashes, of the apocrine sweat glands of Moll or the meibomian sebacious glands often caused by staphylococcus infections. Hordeola can either occur as Hordeola externa affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll or as Hordeola interna affecting the meibomian sebacious glands. In contrast to chalazia, hordeola are extremely painful and can cause extreme local swelling.
http://purl.obolibrary.org/obo/HP_0010609	Skin tags	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Cutaneous skin tags also known as acrochorda or fibroepithelial polyps are small benign tumors that may either form secondarily over time primarily in areas where the skin forms creases, such as the neck, armpit or groin or may also be present at birth, in which case they usually occur in the periauricular region.
http://purl.obolibrary.org/obo/HP_0010614	Fibroma	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		Benign tumors that are composed of fibrous or connective tissue. They can grow in all organs, arising from mesenchyme tissue. The term "fibroblastic" or "fibromatous" is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors.
http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		A tumor (abnormal growth of tissue) of the skeleton.
http://purl.obolibrary.org/obo/HP_0010624	Aplastic/hypoplastic toenail	http://purl.obolibrary.org/obo/HP_0008388	Abnormal toenail morphology		Absence or underdevelopment of the toenail.
http://purl.obolibrary.org/obo/HP_0010628	Facial palsy	http://purl.obolibrary.org/obo/HP_0010827	Abnormal seventh cranial physiology		Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form.
http://purl.obolibrary.org/obo/HP_0010629	Abnormal morphology of the cortex of the humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		Any abnormality affecting the cortex of the humerus.
http://purl.obolibrary.org/obo/HP_0010647	Abnormal elasticity of skin	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Any abnormal increase or reduction in skin elasticity.
http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		An abnormality of the Meninges, including any abnormality of the Dura mater, the Arachnoid mater, and the Pia mater.
http://purl.obolibrary.org/obo/HP_0010655	Epiphyseal stippling	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses.
http://purl.obolibrary.org/obo/HP_0010656	Abnormal epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification		An abnormality of the formation and mineralization of an epiphysis.
http://purl.obolibrary.org/obo/HP_0010662	Abnormal diencephalon morphology	http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology		An abnormality of the Diencephalon, which together with the cerebrum (telencephalon) makes up the forebrain.
http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		The presence of an abnormal curvature of the vertebral column.
http://purl.obolibrary.org/obo/HP_0010696	Polar cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A type of Congenital cataract in which the opacities occupy the subcapsular cortex at the anterior or posterior pole of the lens.
http://purl.obolibrary.org/obo/HP_0010702	Increased circulating immunoglobulin concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		An increased level of gamma globulin (immunoglobulin) in the blood.
http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		An abnormality of the texture of the hair.
http://purl.obolibrary.org/obo/HP_0010721	Abnormal hair whorl	http://purl.obolibrary.org/obo/HP_0011361	Congenital abnormal hair pattern		An abnormal hair whorl (that is, a patch of hair growing in the opposite direction of the rest of the hair).
http://purl.obolibrary.org/obo/HP_0010760	Absent toe	http://purl.obolibrary.org/obo/HP_0001991	Aplasia/Hypoplasia of toe		Aplasia of a toe. That is, absence of all phalanges of a non-hallux digit of the foot and the associated soft tissues.
http://purl.obolibrary.org/obo/HP_0010762	Chordoma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A chordoma is a tumor that arises from embryonic remnants of the notochord along the length of the neuraxis. Chordomas generally occur in the sacrum, intracranially at the clivus, or along the spinal axis.
http://purl.obolibrary.org/obo/HP_0010765	Palmar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		Abnormal thickening of the skin localized to the palm of the hand.
http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the skeletal system		Deposition of calcium salts in a tissue or location in which calcification does not normally occur.
http://purl.obolibrary.org/obo/HP_0010767	Sacrococcygeal pilonidal abnormality	http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology		The presence of a cyst, fistula, or abscess in the sacrococcygeal region (gluteal crease) characteristically accompanied by hair and skin folds.
http://purl.obolibrary.org/obo/HP_0010781	Skin dimple	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Skin dimples are cutaneous indentations that are the result of tethering of the skin to underlying structures (bone) causing an indentation.
http://purl.obolibrary.org/obo/HP_0010783	Erythema	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.
http://purl.obolibrary.org/obo/HP_0010784	Uterine neoplasm	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		A tumor (abnormal growth of tissue) of the uterus.
http://purl.obolibrary.org/obo/HP_0010788	Testicular neoplasm	http://purl.obolibrary.org/obo/HP_0100848	Neoplasm of the male external genitalia		The presence of a neoplasm of the testis.
http://purl.obolibrary.org/obo/HP_0010831	Impaired proprioception	http://purl.obolibrary.org/obo/HP_0003474	Somatic sensory dysfunction		A loss or impairment of the sensation of the relative position of parts of the body and joint position.
http://purl.obolibrary.org/obo/HP_0010834	Trophic changes related to pain	http://purl.obolibrary.org/obo/HP_0010832	Abnormality of pain sensation		Trophic changes is a term used to describe abnormalities in the area of pain that include primarily wasting away of the skin, tissues, or muscle, thinning of the bones, and changes in how the hair or nails grow, including thickening or thinning of hair or brittle nails.
http://purl.obolibrary.org/obo/HP_0010850	EEG with spike-wave complexes	http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges		Complexes of spikes (<70 ms) and sharp waves (70-200 ms), which are sharp transient waves that have a strong association with epilepsy, in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010864	Severe intellectual disability	http://purl.obolibrary.org/obo/HP_0001249	Intellectual disability		Severe intellectual disability (ID) is defined as a type of ID characterized by severely sub-average adaptive functioning and intellectual functioning, with an intelligence quotient (IQ) the range of 20-34.
http://purl.obolibrary.org/obo/HP_0010866	Abdominal wall defect	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		An incomplete closure of the abdominal wall.
http://purl.obolibrary.org/obo/HP_0010872	T-wave inversion	http://purl.obolibrary.org/obo/HP_0005135	Abnormal T-wave		An inversion of the T-wave (which is normally positive).
http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		An abnormal level of a circulating protein in the blood.
http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord	http://purl.obolibrary.org/obo/HP_0001194	Abnormalities of placenta or umbilical cord		An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta.
http://purl.obolibrary.org/obo/HP_0010893	Abnormal circulating phenylalanine concentration	http://purl.obolibrary.org/obo/HP_0004338	Abnormal circulating aromatic amino acid concentration		Any deviation from the normal concentration of phenylalanine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010895	Abnormal circulating glycine concentration	http://purl.obolibrary.org/obo/HP_0010894	Abnormal circulating serine family amino acid concentration		Any deviation from the normal concentration of glycine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010900	Abnormal circulating threonine concentration	http://purl.obolibrary.org/obo/HP_0010899	Abnormal circulating aspartate family amino acid concentration		Any deviation from the normal concentration of threonine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010901	Abnormal circulating methionine concentration	http://purl.obolibrary.org/obo/HP_0010899	Abnormal circulating aspartate family amino acid concentration		Any deviation from the normal concentration of methionine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010903	Abnormal circulating glutamine concentration	http://purl.obolibrary.org/obo/HP_0010902	Abnormal circulating glutamine family amino acid concentration		Any deviation from the normal concentration of glutamine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010907	Abnormal circulating proline concentration	http://purl.obolibrary.org/obo/HP_0010902	Abnormal circulating glutamine family amino acid concentration		Any deviation from the normal concentration of proline in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010908	Abnormal circulating lysine concentration	http://purl.obolibrary.org/obo/HP_0010899	Abnormal circulating aspartate family amino acid concentration		Any deviation from the normal concentration of lysine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010909	Abnormal circulating arginine concentration	http://purl.obolibrary.org/obo/HP_0010902	Abnormal circulating glutamine family amino acid concentration		Any deviation from the normal concentration of arginine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010916	Abnormal circulating alanine concentration	http://purl.obolibrary.org/obo/HP_0010915	Abnormal circulating pyruvate family amino acid concentration		An abnormality of an alanine metabolic process.
http://purl.obolibrary.org/obo/HP_0010917	Abnormal circulating tyrosine concentration	http://purl.obolibrary.org/obo/HP_0004338	Abnormal circulating aromatic amino acid concentration		Any deviation from the normal concentration of tyrosine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010918	Abnormal circulating cysteine concentration	http://purl.obolibrary.org/obo/HP_0004339	Abnormal circulating sulfur-containing amino acid concentration		An abnormality of a cysteine metabolic process.
http://purl.obolibrary.org/obo/HP_0010919	Abnormal circulating homocysteine concentration	http://purl.obolibrary.org/obo/HP_0004339	Abnormal circulating sulfur-containing amino acid concentration		An abnormality of a homocysteine metabolic process.
http://purl.obolibrary.org/obo/HP_0010931	Abnormal circulating sodium concentration	http://purl.obolibrary.org/obo/HP_0010930	Abnormal circulating monovalent inorganic cation concentration		Any deviation from the normal concentration of sodium in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010932	Abnormal circulating nucleobase concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		An abnormality of a nucleobase metabolic process.
http://purl.obolibrary.org/obo/HP_0010933	Hyperxanthinemia	http://purl.obolibrary.org/obo/HP_0004368	Elevated circulating purine concentration		An increased level of xanthine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010935	Abnormality of the upper urinary tract	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the urinary system		An abnormality of the upper urinary tract.
http://purl.obolibrary.org/obo/HP_0010936	Abnormality of the lower urinary tract	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the urinary system		An abnormality of the lower urinary tract.
http://purl.obolibrary.org/obo/HP_0010938	Abnormal external nose morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		An abnormality of the external nose.
http://purl.obolibrary.org/obo/HP_0010946	Dilatation of the renal pelvis	http://purl.obolibrary.org/obo/HP_0010944	Abnormal renal pelvis morphology		The presence of dilatation of the renal pelvis.
http://purl.obolibrary.org/obo/HP_0010948	Abnormal fetal cardiovascular morphology	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		A structural abnormality of the fetal circulation system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0010950	Abnormal fourth ventricle morphology	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		An abnormality of the fourth ventricle.
http://purl.obolibrary.org/obo/HP_0010955	Dilatation of the bladder	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		The presence of a dilated urinary bladder.
http://purl.obolibrary.org/obo/HP_0010964	Abnormal circulating long-chain fatty-acid concentration	http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration		Any deviation from the normal concentration of a long-chain fatty acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010967	Abnormal circulating carnitine concentration	http://purl.obolibrary.org/obo/HP_0010966	Abnormal circulating fatty acid anion concentration		Any deviation from the normal concentration of carnitine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production	http://purl.obolibrary.org/obo/HP_0001903	Anemia		A kind of anemia characterized by inadequate production of erythrocytes.
http://purl.obolibrary.org/obo/HP_0010974	Abnormal myeloid leukocyte morphology	http://purl.obolibrary.org/obo/HP_0001881	Abnormal leukocyte morphology		An abnormality of myeloid leukocytes.
http://purl.obolibrary.org/obo/HP_0010977	Abnormal phagocytosis	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		An abnormal functioning of phagocytosis. Phagocytosis is an elegant but complex process for the ingestion and elimination of pathogens, but it is also important for the elimination of apoptotic cells and hence fundamental for tissue homeostasis. Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation.
http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the immune system		A functional abnormality of the immune system.
http://purl.obolibrary.org/obo/HP_0010980	Hyperlipoproteinemia	http://purl.obolibrary.org/obo/HP_0010979	Abnormal circulating lipoprotein cholesterol concentration		An abnormal increase in the level of lipoprotein cholesterol in the blood.
http://purl.obolibrary.org/obo/HP_0010981	Hypolipoproteinemia	http://purl.obolibrary.org/obo/HP_0010979	Abnormal circulating lipoprotein cholesterol concentration		An abnormal decrease in the level of lipoprotein cholesterol in the blood.
http://purl.obolibrary.org/obo/HP_0010987	Abnormal cellular immune system morphology	http://purl.obolibrary.org/obo/HP_0032251	Abnormal immune system morphology		An abnormality of the morphology or counts of the cells that make up the immune system.
http://purl.obolibrary.org/obo/HP_0010989	Abnormality of the intrinsic pathway	http://purl.obolibrary.org/obo/HP_0003256	Abnormality of the coagulation cascade		An abnormality of the intrinsic pathway (also known as the contact activation pathway) of the coagulation cascade.
http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway	http://purl.obolibrary.org/obo/HP_0003256	Abnormality of the coagulation cascade		An abnormality of blood coagulation, common pathway.
http://purl.obolibrary.org/obo/HP_0010991	Abnormal morphology of the abdominal musculature	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		An abnormality of the abdominal musculature.
http://purl.obolibrary.org/obo/HP_0010993	Abnormal cerebral subcortex morphology	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		An abnormality of the cerebral subcortex.
http://purl.obolibrary.org/obo/HP_0010994	Abnormal corpus striatum morphology	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		Abnormality of the striatum, which is the largest nucleus of the basal ganglia, comprising the caudate, putamen and ventral striatum, including the nucleus accumbens.
http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		Any deviation from the normal concentration of dicarboxylic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		Any deviation from the normal concentration of monocarboxylic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries.
http://purl.obolibrary.org/obo/HP_0011006	Abnormal morphology of the musculature of the neck	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		An abnormality of the neck musculature.
http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern	http://purl.obolibrary.org/obo/HP_0031797	Clinical course		The speed at which disease manifestations appear and develop.
http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		A deviation from the normal concentration of a carbohydrate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011014	Abnormal glucose homeostasis	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		Abnormality of glucose homeostasis.
http://purl.obolibrary.org/obo/HP_0011015	Abnormal blood glucose concentration	http://purl.obolibrary.org/obo/HP_0020347	Abnormal circulating monosaccharide concentration		An abnormality of the concentration of glucose in the blood.
http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology	http://purl.obolibrary.org/obo/HP_0025354	Abnormal cellular phenotype		An abnormality in a cellular process.
http://purl.obolibrary.org/obo/HP_0011018	Abnormality of the cell cycle	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An abnormality of the cell cycle.
http://purl.obolibrary.org/obo/HP_0011019	Abnormality of chromosome condensation	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An abnormality of chromosome condensation.
http://purl.obolibrary.org/obo/HP_0011020	Abnormality of mucopolysaccharide metabolism	http://purl.obolibrary.org/obo/HP_0004371	Abnormality of glycosaminoglycan metabolism		An abnormality of the metabolism of mucopolysaccharide.
http://purl.obolibrary.org/obo/HP_0011021	Abnormal circulating enzyme concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of an enzyme in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011023	Abnormal circulating prostaglandin concentration	http://purl.obolibrary.org/obo/HP_0030361	Abnormal circulating eicosanoid concentration		Any deviation from the normal concentration of prostaglandin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of the cardiovascular system		Abnormal functionality of the cardiovascular system.
http://purl.obolibrary.org/obo/HP_0011026	Aplasia/Hypoplasia of the vagina	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		Aplasia or developmental hypoplasia of the vagina.
http://purl.obolibrary.org/obo/HP_0011031	Abnormality of iron homeostasis	http://purl.obolibrary.org/obo/HP_0011030	Abnormal circulating transition element cation concentration		An abnormality of the homeostasis (concentration) of iron cation.
http://purl.obolibrary.org/obo/HP_0011032	Abnormality of fluid regulation	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		An abnormality of the regulation of body fluids.
http://purl.obolibrary.org/obo/HP_0011034	Amyloid deposition	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Pathologic deposits of specific fibrillar protein aggregates with distinct microscopic properties, particularly affinity for the dye Congo red with typical birefringence.
http://purl.obolibrary.org/obo/HP_0011035	Abnormal renal cortex morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An abnormality of the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption	http://purl.obolibrary.org/obo/HP_0000124	Renal tubular dysfunction		An abnormality of renal absorption.
http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		An abnormality of the helix. The helix is the outer rim of the ear that extends from the insertion of the ear on the scalp (root) to the termination of the cartilage at the earlobe.
http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		An abnormality of the intrahepatic bile duct.
http://purl.obolibrary.org/obo/HP_0011042	Abnormal circulating potassium concentration	http://purl.obolibrary.org/obo/HP_0010930	Abnormal circulating monovalent inorganic cation concentration		Any deviation from the normal concentration of potassium(1+) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011043	Abnormal circulating adrenocorticotropin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An abnormal concentration of corticotropin in the blood.
http://purl.obolibrary.org/obo/HP_0011061	Abnormality of dental structure	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		An abnormality of the structure or composition of the teeth.
http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		An abnormality of morphology of the incisor tooth.
http://purl.obolibrary.org/obo/HP_0011071	Abnormal permanent molar morphology	http://purl.obolibrary.org/obo/HP_0011070	Abnormal molar morphology		An abnormality of morphology of permanent molar.
http://purl.obolibrary.org/obo/HP_0011073	Abnormality of dental color	http://purl.obolibrary.org/obo/HP_0011061	Abnormality of dental structure		A developmental defect of tooth color.
http://purl.obolibrary.org/obo/HP_0011079	Impacted tooth	http://purl.obolibrary.org/obo/HP_0000706	Eruption failure		A tooth that has not erupted because of local impediments (overcrowding or fibrous gum overgrowth).
http://purl.obolibrary.org/obo/HP_0011081	Incisor macrodontia	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		Increased size of the incisor tooth.
http://purl.obolibrary.org/obo/HP_0011096	Peripheral demyelination	http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination		A loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0011100	Intestinal atresia	http://purl.obolibrary.org/obo/HP_0002589	Gastrointestinal atresia		An abnormal closure, or atresia of the tubular structure of the intestine.
http://purl.obolibrary.org/obo/HP_0011103	Abnormal left ventricular outflow tract morphology	http://purl.obolibrary.org/obo/HP_0001711	Abnormal left ventricle morphology		An abnormality of the outflow tract of the left ventricle.
http://purl.obolibrary.org/obo/HP_0011119	Abnormal nasal dorsum morphology	http://purl.obolibrary.org/obo/HP_0010938	Abnormal external nose morphology		An abnormality of the nasal dorsum, also known as the nasal ridge.
http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology	http://purl.obolibrary.org/obo/HP_0000951	Abnormality of the skin		Any morphological abnormality of the skin.
http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology	http://purl.obolibrary.org/obo/HP_0000951	Abnormality of the skin		Any abnormality of the physiological function of the skin.
http://purl.obolibrary.org/obo/HP_0011125	Abnormal dermal melanosome morphology	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		An abnormality of the melanosomes, i.e., of the cellular organelles in which melanin pigments are synthesized and stored within melanocytes (the cells that produce pigment in the dermis).
http://purl.obolibrary.org/obo/HP_0011138	Abnormal skin adnexa morphology	http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the integument		An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.
http://purl.obolibrary.org/obo/HP_0011145	Symptomatic seizures	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed.
http://purl.obolibrary.org/obo/HP_0011146	Dialeptic seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A dialeptic seizure is a type of seizure characterized predominantly by reduced responsiveness or awareness and with subsequent at least partial amnesia of the event.
http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure	http://purl.obolibrary.org/obo/HP_0020219	Motor seizure		A type of focal-onset seizure characterized by a motor sign as its initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011182	Interictal epileptiform activity		EEG discharges recorded on the entire scalp typically seen in persons with epilepsy.
http://purl.obolibrary.org/obo/HP_0011217	Abnormal shape of the occiput	http://purl.obolibrary.org/obo/HP_0012294	Abnormal occipital bone morphology		An abnormal shape of occiput.
http://purl.obolibrary.org/obo/HP_0011218	Abnormal shape of the frontal region	http://purl.obolibrary.org/obo/HP_0430000	Abnormal frontal bone morphology		An abnormal shape of the frontal part of the head.
http://purl.obolibrary.org/obo/HP_0011279	Abnormality of urine bicarbonate level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		An abnormal amount of hydrogencarbonate in the urine.
http://purl.obolibrary.org/obo/HP_0011280	Abnormality of urine calcium concentration	http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration		An abnormality of calcium concentration in the urine.
http://purl.obolibrary.org/obo/HP_0011283	Abnormal metencephalon morphology	http://purl.obolibrary.org/obo/HP_0011282	Abnormal hindbrain morphology		An abnormality of the metencephalon. The metencephalon is the part of the hindbrain that consists of the pons and the cerebellum.
http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology	http://purl.obolibrary.org/obo/HP_0002813	Abnormal limb bone morphology		A morphological abnormality of a digit, i.e., of a finger or toe.
http://purl.obolibrary.org/obo/HP_0011298	Prominent digit pad	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		A soft tissue prominence of the ventral aspects of the fingertips or toe tips.
http://purl.obolibrary.org/obo/HP_0011304	Broad thumb	http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand		Increased thumb width without increased dorso-ventral dimension.
http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology	http://purl.obolibrary.org/obo/HP_0011844	Abnormal appendicular skeleton morphology		An abnormality of size or shape of the long bones.
http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology	http://purl.obolibrary.org/obo/HP_0000235	Abnormal cranial suture/fontanelle morphology		An abnormality of the fontanelle.
http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures	http://purl.obolibrary.org/obo/HP_0000235	Abnormal cranial suture/fontanelle morphology		Any anomaly of a cranial suture, that is one of the six membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant.
http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		An abnormality of the outline, configuration, or contour of the mouth.
http://purl.obolibrary.org/obo/HP_0011339	Abnormality of upper lip vermillion	http://purl.obolibrary.org/obo/HP_0000177	Abnormal upper lip morphology		An abnormality of the vermilion border, the sharp demarcation between the lip (red colored) and the adjacent normal skin.
http://purl.obolibrary.org/obo/HP_0011347	Abnormality of ocular abduction	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		An abnormality involving the movement of the eye outwards.
http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		An abnormality of the skin that is not localized to any one particular region.
http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		A lesion of the skin that is located in a specific region rather than being generalized.
http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		An abnormality of the skin that is restricted to a particular body region.
http://purl.obolibrary.org/obo/HP_0011358	Generalized hypopigmentation of hair	http://purl.obolibrary.org/obo/HP_0005599	Hypopigmentation of hair		Reduced pigmentation of hair diffusely.
http://purl.obolibrary.org/obo/HP_0011360	Acquired abnormal hair pattern	http://purl.obolibrary.org/obo/HP_0010720	Abnormal hair pattern		An abnormality of the distribution of hair growth that is acquired during the course of life.
http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		An abnormal amount of hair.
http://purl.obolibrary.org/obo/HP_0011363	Abnormality of hair growth rate	http://purl.obolibrary.org/obo/HP_0040170	Abnormality of hair growth		Hair whose growth rate deviates from the norm.
http://purl.obolibrary.org/obo/HP_0011365	Patchy hypopigmentation of hair	http://purl.obolibrary.org/obo/HP_0005599	Hypopigmentation of hair		Reduced pigmentation of hair in patches.
http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening	http://purl.obolibrary.org/obo/HP_0001072	Thickened skin		Thickening of the epidermal layer of the skin.
http://purl.obolibrary.org/obo/HP_0011370	Recurrent cutaneous fungal infections	http://purl.obolibrary.org/obo/HP_0002841	Recurrent fungal infections		Increased susceptibility to cutaneous fungal infections as manifested by recurrent episodes of cutaneous fungal infections.
http://purl.obolibrary.org/obo/HP_0011373	Incomplete partition of the cochlea	http://purl.obolibrary.org/obo/HP_0008554	Cochlear malformation		Incomplete formation of the cochlear partition. The scala vestibuli and scala tympani separated by the cochlear partition, except in the apical turn where the two scalae are in continuity via the helicotrema.
http://purl.obolibrary.org/obo/HP_0011389	Functional abnormality of the inner ear	http://purl.obolibrary.org/obo/HP_0031704	Abnormal ear physiology		An abnormality of the function of the inner ear.
http://purl.obolibrary.org/obo/HP_0011390	Abnormal inner ear morphology	http://purl.obolibrary.org/obo/HP_0000359	Abnormality of the inner ear		A structural anomaly of the internal part of the ear.
http://purl.obolibrary.org/obo/HP_0011400	Abnormal CNS myelination	http://purl.obolibrary.org/obo/HP_0012447	Abnormal myelination		An abnormality of myelination of nerves in the central nervous system.
http://purl.obolibrary.org/obo/HP_0011420	Age of death	http://purl.obolibrary.org/obo/HP_0040006	Mortality/Aging		The age group when the cessation of life happens.
http://purl.obolibrary.org/obo/HP_0011422	Abnormal circulating chloride concentration	http://purl.obolibrary.org/obo/HP_0020330	Abnormal circulating inorganic anion concentration		Any deviation from the normal concentration of chloride in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011425	Fetal ultrasound soft marker	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		An finding upon obstetric ultrasound examination performed at around 16 to 20 weeks of gestation that is abnormal but not clearly identifiable as a fetal anatomic malformation or growth restriction. Such findings are known as soft markers since they are associated with increased risk for fetal aneuploidy or other disorders.
http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An anomaly of the control or production of movement in the central nervous system.
http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		Cognitive, psychiatric, or memory anomaly.
http://purl.obolibrary.org/obo/HP_0011450	Unusual CNS infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infections of the central nervous system, as manifested by recurrent, severe, or invasive infections involving the brain, meninges, or spinal cord. This can include infections caused by opportunistic or atypical pathogens, or common pathogens presenting with unusual severity or in anatomical locations.
http://purl.obolibrary.org/obo/HP_0011452	Functional abnormality of the middle ear	http://purl.obolibrary.org/obo/HP_0000370	Abnormality of the middle ear		An abnormality of the function of the middle ear.
http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom	http://purl.obolibrary.org/obo/HP_0025032	Abnormality of digestive system physiology		A subjective manifestation of disease localized to the abdomen.
http://purl.obolibrary.org/obo/HP_0011474	Childhood onset sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		Sensorineural hearing impairment with childhood onset.
http://purl.obolibrary.org/obo/HP_0011479	Abnormal lacrimal punctum morphology	http://purl.obolibrary.org/obo/HP_0000614	Abnormal nasolacrimal system morphology		An abnormality of the lacrimal punctum, an opening on the eyelid close to the medial canthus that drains tears from the conjunctival sac into the lacrimal duct in the same eyelid.
http://purl.obolibrary.org/obo/HP_0011481	Abnormal lacrimal duct morphology	http://purl.obolibrary.org/obo/HP_0000614	Abnormal nasolacrimal system morphology		An abnormality of the lacrimal duct, a duct that drain tears from the conjunctiva, via the lacrimal puncta, into the lacrimal sac.
http://purl.obolibrary.org/obo/HP_0011493	Central opacification of the cornea	http://purl.obolibrary.org/obo/HP_0007759	Opacification of the corneal stroma		Reduced transparency of the central portion of the corneal stroma.
http://purl.obolibrary.org/obo/HP_0011495	Abnormal corneal epithelium morphology	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		Abnormality of the corneal epithelium, that is of the epithelial tissue that covers the front of the cornea.
http://purl.obolibrary.org/obo/HP_0011514	Abnormality of binocular vision	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		An abnormality of binocular vision, that is of the ability to synthesize the visual inputs from both eyes to a single image with perception of depth.
http://purl.obolibrary.org/obo/HP_0011519	Anomalous trichromacy	http://purl.obolibrary.org/obo/HP_0007641	Dyschromatopsia		Individuals with anomalous trichromacy possess three types of cones, but one of the three types of cones has an abnormal spectral sensitivity compared to normal cones.
http://purl.obolibrary.org/obo/HP_0011526	Abnormality of lens shape	http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology		An abnormal shape of the lens.
http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Abnormality of the spatial relationship of the cardiac segments to other components of the heart.
http://purl.obolibrary.org/obo/HP_0011563	Abnormal ventriculoarterial connection	http://purl.obolibrary.org/obo/HP_0011545	Abnormal connection of the cardiac segments		An abnormality of the circulatory connection between the ventricles and the pulmonary artery and aorta.
http://purl.obolibrary.org/obo/HP_0011603	Congenital malformation of the great arteries	http://purl.obolibrary.org/obo/HP_0030962	Abnormal morphology of the great vessels		Defect or defects of the morphogenesis of the aorta and pulmonary arteries.
http://purl.obolibrary.org/obo/HP_0011620	Abnormality of abdominal situs	http://purl.obolibrary.org/obo/HP_0002012	Abnormality of the abdominal organs		An abnormality of the abdominal situs, i.e., of the sidedness of the abdomen and its organs.
http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia	http://purl.obolibrary.org/obo/HP_0030956	Abnormality of cardiovascular system electrophysiology		Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both.
http://purl.obolibrary.org/obo/HP_0011702	Abnormal electrophysiology of sinoatrial node origin	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		An abnormality of the sinoatrial (SA) node in the right atrium. THe SA node acts as the pacemaker of the heart.
http://purl.obolibrary.org/obo/HP_0011723	Congenital malformation of the right heart	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Defect or defects of the morphogenesis of the right heart identifiable at birth.
http://purl.obolibrary.org/obo/HP_0011729	Abnormality of joint mobility	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		An abnormality in the range and ease of motion of joints across their normal range.
http://purl.obolibrary.org/obo/HP_0011731	Abnormality of circulating cortisol level	http://purl.obolibrary.org/obo/HP_0012111	Abnormality of circulating glucocorticoid level		An abnormality of the concentration of cortisol in the blood.
http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology	http://purl.obolibrary.org/obo/HP_0031071	Abnormal endocrine morphology		Any structural anomaly of the adrenal glands.
http://purl.obolibrary.org/obo/HP_0011733	Abnormality of adrenal physiology	http://purl.obolibrary.org/obo/HP_0000834	Abnormality of the adrenal glands		A functional abnormality of the adrenal glands.
http://purl.obolibrary.org/obo/HP_0011747	Abnormality of the anterior pituitary	http://purl.obolibrary.org/obo/HP_0012503	Abnormal pituitary gland morphology		An abnormality of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland.
http://purl.obolibrary.org/obo/HP_0011750	Neoplasm of the anterior pituitary	http://purl.obolibrary.org/obo/HP_0011747	Abnormality of the anterior pituitary		A tumor (abnormal growth of tissue) of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland.
http://purl.obolibrary.org/obo/HP_0011751	Abnormal posterior pituitary morphogenesis	http://purl.obolibrary.org/obo/HP_0012503	Abnormal pituitary gland morphology		An abnormality of the neurohypophysis, which is also known as the posterior lobe of the hypophysis.
http://purl.obolibrary.org/obo/HP_0011767	Abnormality of the parathyroid physiology	http://purl.obolibrary.org/obo/HP_0000828	Abnormality of the parathyroid gland		A functional abnormality of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0011768	Parathyroid dysgenesis	http://purl.obolibrary.org/obo/HP_0011766	Abnormal parathyroid morphology		Abnormal embryonic development of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology	http://purl.obolibrary.org/obo/HP_0000820	Abnormality of the thyroid gland		A structural abnormality of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology	http://purl.obolibrary.org/obo/HP_0002664	Neoplasm		Neoplasm categorized according to type of histological abnormality.
http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site	http://purl.obolibrary.org/obo/HP_0002664	Neoplasm		Neoplasm categorized according to the anatomical site of origin of the neoplasm.
http://purl.obolibrary.org/obo/HP_0011794	Embryonal renal neoplasm	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		The presence of an embryonal neoplasm of the kidney that primarily affects children.
http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology	http://purl.obolibrary.org/obo/HP_0003011	Abnormality of the musculature		A functional abnormality of a skeletal muscle.
http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology	http://purl.obolibrary.org/obo/HP_0003011	Abnormality of the musculature		A structural abnormality of a skeletal muscle.
http://purl.obolibrary.org/obo/HP_0011813	Increased cerebral lipofuscin	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		Lipofuscin (age pigment) is a brown-yellow, electron-dense, autofluorescent material that accumulates progressively over time in lysosomes of postmitotic cells, such as neurons and cardiac myocytes. This term pertains if there is an increase in the accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient.
http://purl.obolibrary.org/obo/HP_0011815	Cephalocele	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		A congenital defect in the skull, whereby there is a protrusion of part of the cranial contents through a congenital defect in the cranium, usually covered with skin or mucous membrane. The term encephalocele refers to a subclass of these lesions in which brain tissue protrudes through the defect.
http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		An abnormality of one or more of the set of bones that make up the facial skeleton.
http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		Abnormality of the oral mucosa.
http://purl.obolibrary.org/obo/HP_0011839	Abnormal total T cell number	http://purl.obolibrary.org/obo/HP_0002843	Abnormal T cell morphology		Abnormal increase or decrease of absolute number (either count per volume or proportion of total lymphocytes) of T cells or of a subset of T cells, commonly characterized as CD3+ lymphocytes, in the blood, compared to a reference range for a given sex and age-group. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology	http://purl.obolibrary.org/obo/HP_0031409	Abnormal lymphocyte physiology		A functional anomaly of T cells.
http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the skeletal system		An abnormality of the form, structure, or size of the skeletal system.
http://purl.obolibrary.org/obo/HP_0011843	Abnormal musculoskeletal physiology	http://purl.obolibrary.org/obo/HP_0033127	Abnormality of the musculoskeletal system		An abnormality of the function of the skeletal system.
http://purl.obolibrary.org/obo/HP_0011844	Abnormal appendicular skeleton morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles.
http://purl.obolibrary.org/obo/HP_0011849	Abnormal bone ossification	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		Any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
http://purl.obolibrary.org/obo/HP_0011862	Abnormal bone collagen fibril morphology	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		Any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.
http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology	http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology		An anomaly of the ilium ala. This is the large expanded portion of the ilum which bounds the greater pelvis laterally.
http://purl.obolibrary.org/obo/HP_0011869	Abnormal platelet function	http://purl.obolibrary.org/obo/HP_0001872	Abnormality of thrombocytes		Any anomaly in the function of thrombocytes.
http://purl.obolibrary.org/obo/HP_0011873	Abnormal platelet count	http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology		Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood.
http://purl.obolibrary.org/obo/HP_0011877	Increased mean platelet volume	http://purl.obolibrary.org/obo/HP_0011876	Abnormal platelet volume		Average platelet volume above the upper limit of the normal reference interval.
http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression	http://purl.obolibrary.org/obo/HP_0011869	Abnormal platelet function		Presence of reduced amount of a membrane protein on the cell membrane of platelets. This feature is typically measured by flow cytometry.
http://purl.obolibrary.org/obo/HP_0011885	Hemorrhage of the eye	http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage		Bleeding from vessels of the various tissues of the eye.
http://purl.obolibrary.org/obo/HP_0011893	Abnormal leukocyte count	http://purl.obolibrary.org/obo/HP_0001881	Abnormal leukocyte morphology		Number of leukocytes per volume of blood beyond normal limits.
http://purl.obolibrary.org/obo/HP_0011895	Anemia due to reduced life span of red cells	http://purl.obolibrary.org/obo/HP_0001903	Anemia		A type of anemia related to a reduction in the average life span of red blood cells in the peripheral circulation, which is normally around 120 days.
http://purl.obolibrary.org/obo/HP_0011912	Abnormality of the glenoid fossa	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		An anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus.
http://purl.obolibrary.org/obo/HP_0011927	Short digit	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened.
http://purl.obolibrary.org/obo/HP_0011932	Abnormal superior cerebellar peduncle morphology	http://purl.obolibrary.org/obo/HP_0011931	Abnormal cerebellar peduncle morphology		An anomaly of the superior cerebellar peduncle.
http://purl.obolibrary.org/obo/HP_0011947	Respiratory tract infection	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		An infection of the upper or lower respiratory tract.
http://purl.obolibrary.org/obo/HP_0011951	Aspiration pneumonia	http://purl.obolibrary.org/obo/HP_0002090	Pneumonia		Pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract.
http://purl.obolibrary.org/obo/HP_0011965	Abnormal circulating citrulline concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Any deviation from the normal concentration of citrulline in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011976	Elevated urinary catecholamine level	http://purl.obolibrary.org/obo/HP_0011281	Abnormality of urine catecholamine level		The concentration of a catecholamine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0011986	Ectopic ossification	http://purl.obolibrary.org/obo/HP_0011849	Abnormal bone ossification		Formation of abnormal, extraskeletal bony tissue, i.e., the presence of bone in soft tissue where bone normally does not exist.
http://purl.obolibrary.org/obo/HP_0011991	Abnormal total neutrophil count	http://purl.obolibrary.org/obo/HP_0032309	Abnormal granulocyte count		A deviation from the normal range of neutrophil cell counts in the circulation.
http://purl.obolibrary.org/obo/HP_0011993	Impaired neutrophil bactericidal activity	http://purl.obolibrary.org/obo/HP_0011990	Abnormal neutrophil physiology		A reduction in the ability of neutrophils to kill bacteria.
http://purl.obolibrary.org/obo/HP_0011994	Abnormal atrial septum morphology	http://purl.obolibrary.org/obo/HP_0001671	Abnormal cardiac septum morphology		An abnormality of the interatrial septum.
http://purl.obolibrary.org/obo/HP_0012020	Right aortic arch	http://purl.obolibrary.org/obo/HP_0011587	Abnormal branching pattern of the aortic arch		Aorta descends on right instead of on the left.
http://purl.obolibrary.org/obo/HP_0012062	Bone cyst	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		A fluid filled cavity that develops with a bone.
http://purl.obolibrary.org/obo/HP_0012067	Glycopeptiduria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Increased excretion of glycopeptides in the urine. Glycopeptides are peptides with carbohydrate moieties covalently attached to the side chains of the amino acid residues.
http://purl.obolibrary.org/obo/HP_0012072	Aciduria	http://purl.obolibrary.org/obo/HP_0032943	Abnormal urine pH		Excretion of urine with an acid pH, i.e., having an increased hydrogen ion concentration.
http://purl.obolibrary.org/obo/HP_0012084	Abnormality of skeletal muscle fiber size	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Any abnormality of the size of the skeletal muscle cell.
http://purl.obolibrary.org/obo/HP_0012091	Abnormality of pancreas physiology	http://purl.obolibrary.org/obo/HP_0001732	Abnormality of the pancreas		An anomaly of the function of the pancreas.
http://purl.obolibrary.org/obo/HP_0012099	Abnormal circulating catecholamine concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An abnormal catecholamine concentration in the blood.
http://purl.obolibrary.org/obo/HP_0012100	Abnormal circulating creatinine concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		An abnormal concentration of creatinine in the blood.
http://purl.obolibrary.org/obo/HP_0012103	Abnormality of the mitochondrion	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An anomaly of the mitochondrion, the membranous cytoplasmic organelle the interior of which is subdivided by cristae. The mitochondrion is a self replicating organelle that is the site of tissue respiration.
http://purl.obolibrary.org/obo/HP_0012116	Abnormal circulating albumin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of albumin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0012122	Anterior uveitis	http://purl.obolibrary.org/obo/HP_0000554	Uveitis		Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber.
http://purl.obolibrary.org/obo/HP_0012165	Oligodactyly	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		A developmental defect resulting in the presence of fewer than the normal number of digits.
http://purl.obolibrary.org/obo/HP_0012179	Craniofacial dystonia	http://purl.obolibrary.org/obo/HP_0004373	Focal dystonia		A form of focal dystonia affecting the face and especially the jaw that is induced by the act of speaking. It is an involuntary contraction of the masticatory muscles, resulting in dysarthria or dysphagia.
http://purl.obolibrary.org/obo/HP_0012200	Abnormality of prothrombin	http://purl.obolibrary.org/obo/HP_0003256	Abnormality of the coagulation cascade		An anomaly of clotting factor II, which is known as prothrombin, a vitamin K-dependent proenzyme that functions in the blood coagulation cascade.
http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the kidney		Any structural anomaly of the kidney.
http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology	http://purl.obolibrary.org/obo/HP_0011277	Abnormality of the urinary system physiology		An abnormal functionality of the kidney.
http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology	http://purl.obolibrary.org/obo/HP_0000078	Abnormality of the genital system		A structural or developmental anomaly of any of the tissues involved in the genital system.
http://purl.obolibrary.org/obo/HP_0012252	Abnormal respiratory system morphology	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the respiratory system		A structural anomaly of the respiratory system.
http://purl.obolibrary.org/obo/HP_0012285	Abnormal hypothalamus physiology	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An abnormal functionality of the hypothalamus.
http://purl.obolibrary.org/obo/HP_0012286	Abnormal hypothalamus morphology	http://purl.obolibrary.org/obo/HP_0010662	Abnormal diencephalon morphology		Any structural anomaly of the hypothalamus.
http://purl.obolibrary.org/obo/HP_0012332	Abnormal autonomic nervous system physiology	http://purl.obolibrary.org/obo/HP_0002270	Abnormality of the autonomic nervous system		A functional abnormality of the autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation	http://purl.obolibrary.org/obo/HP_0012346	Abnormal protein glycosylation		An anomaly of protein N-linked glycosylation, i.e., an abnormality of the protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a nitrogen atom in an amino acid residue in a protein.
http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the eye		A structural anomaly of the globe of the eye, or bulbus oculi.
http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the eye		A functional anomaly of the eye.
http://purl.obolibrary.org/obo/HP_0012384	Rhinitis	http://purl.obolibrary.org/obo/HP_0000366	Abnormality of the nose		Inflammation of the nasal mucosa with nasal congestion.
http://purl.obolibrary.org/obo/HP_0012385	Camptodactyly	http://purl.obolibrary.org/obo/HP_0030044	Flexion contracture of digit		The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers or toes cannot be extended to 180 degrees by either active or passive extension.
http://purl.obolibrary.org/obo/HP_0012387	Bronchitis	http://purl.obolibrary.org/obo/HP_5210123	Unusual lower respiratory tract infection		Inflammation of the large airways in the lung including any part of the bronchi from the primary bronchi to the tertiary bronchi.
http://purl.obolibrary.org/obo/HP_0012393	Allergy	http://purl.obolibrary.org/obo/HP_0100326	Immunologic hypersensitivity		An allergy is an immune response or reaction to substances that are usually not harmful.
http://purl.obolibrary.org/obo/HP_0012433	Abnormal social behavior	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		An abnormality of actions or reactions of a person exhibited during social interactions with other individuals.
http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology	http://purl.obolibrary.org/obo/HP_0005264	Abnormality of the gallbladder		A structural anomaly of the gallbladder.
http://purl.obolibrary.org/obo/HP_0012438	Abnormal gallbladder physiology	http://purl.obolibrary.org/obo/HP_0005264	Abnormality of the gallbladder		A functional anomaly of the gallbladder.
http://purl.obolibrary.org/obo/HP_0012439	Abnormal biliary tract physiology	http://purl.obolibrary.org/obo/HP_0001080	Biliary tract abnormality		A functional abnormality of the biliary tree.
http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology	http://purl.obolibrary.org/obo/HP_0001080	Biliary tract abnormality		A structural abnormality of the biliary tree.
http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain.
http://purl.obolibrary.org/obo/HP_0012444	Brain atrophy	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		Partial or complete wasting (loss) of brain tissue that was once present.
http://purl.obolibrary.org/obo/HP_0012447	Abnormal myelination	http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology		Any anomaly in the process by which myelin sheaths are formed and maintained around neurons.
http://purl.obolibrary.org/obo/HP_0012448	Delayed myelination	http://purl.obolibrary.org/obo/HP_0012447	Abnormal myelination		Delayed myelination.
http://purl.obolibrary.org/obo/HP_0012468	Chronic acidosis	http://purl.obolibrary.org/obo/HP_0001941	Acidosis		Longstanding abnormal acid accumulation or depletion of base.
http://purl.obolibrary.org/obo/HP_0012471	Thick vermilion border	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Increased width of the skin of vermilion border region of upper lip.
http://purl.obolibrary.org/obo/HP_0012472	Eclabion	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		A turning outward of the lip or lips, that is, eversion of the lips.
http://purl.obolibrary.org/obo/HP_0012475	Impaired specific antibody response	http://purl.obolibrary.org/obo/HP_0005368	Abnormality of humoral immunity		Reduced ability of the immune system to produce targeted, protective antibodies (immunoglobulins) against specific pathogens or vaccines in the setting of normal or near-normal serum levels of total IgG, IgA, and IgM and normal absolute counts of B cells and T cells.
http://purl.obolibrary.org/obo/HP_0012537	Food intolerance	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.
http://purl.obolibrary.org/obo/HP_0012547	Abnormal involuntary eye movements	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Anomalous movements of the eyes that occur without the subject wanting them to happen.
http://purl.obolibrary.org/obo/HP_0012575	Abnormal nephron morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		A structural anomaly of the nephron.
http://purl.obolibrary.org/obo/HP_0012585	Renal atrophy	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Atrophy of the kidney.
http://purl.obolibrary.org/obo/HP_0012590	Abnormal urine output	http://purl.obolibrary.org/obo/HP_0011036	Abnormality of renal excretion		An abnormal amount of urine production.
http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		An abnormality in the concentration of electrolytes in the urine.
http://purl.obolibrary.org/obo/HP_0012598	Abnormal urine potassium concentration	http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration		An abnormal concentration of potassium(1+) in the urine.
http://purl.obolibrary.org/obo/HP_0012599	Abnormal urine phosphate concentration	http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration		An abnormal phosphate concentration in the urine.
http://purl.obolibrary.org/obo/HP_0012600	Abnormal urine chloride concentration	http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration		An abnormal concentration of chloride in the urine.
http://purl.obolibrary.org/obo/HP_0012612	Abnormal urinary sulfate concentration	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Abnormal concentration of sulfate in the urine.
http://purl.obolibrary.org/obo/HP_0012614	Abnormal urine cytology	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		An anomalous finding in the examination of the urine for cells.
http://purl.obolibrary.org/obo/HP_0012622	Chronic kidney disease	http://purl.obolibrary.org/obo/HP_0000083	Renal insufficiency		Functional anomaly of the kidney persisting for at least three months.
http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology	http://purl.obolibrary.org/obo/HP_0000707	Abnormality of the nervous system		A functional anomaly of the nervous system.
http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology	http://purl.obolibrary.org/obo/HP_0000707	Abnormality of the nervous system		A structural anomaly of the nervous system.
http://purl.obolibrary.org/obo/HP_0012640	Abnormality of intracranial pressure	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		A deviation from the norm of the intracranial pressure.
http://purl.obolibrary.org/obo/HP_0012700	Abnormal large intestine physiology	http://purl.obolibrary.org/obo/HP_0025032	Abnormality of digestive system physiology		A functional anomaly of the large intestine.
http://purl.obolibrary.org/obo/HP_0012703	Abnormal subarachnoid space morphology	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		Abnormality in the space in the meninges beneath the arachnoid membrane and above the pia mater that contains the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology	http://purl.obolibrary.org/obo/HP_0025033	Abnormal digestive system morphology		Abnormal structure of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract	http://purl.obolibrary.org/obo/HP_0011024	Abnormality of the gastrointestinal tract		Abnormal functionality of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0012722	Heart block	http://purl.obolibrary.org/obo/HP_0031546	Cardiac conduction abnormality		Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway.
http://purl.obolibrary.org/obo/HP_0012727	Thoracic aortic aneurysm	http://purl.obolibrary.org/obo/HP_0004942	Aortic aneurysm		An abnormal localized widening (dilatation) of the thoracic aorta.
http://purl.obolibrary.org/obo/HP_0012732	Anorectal anomaly	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		An abnormality of the anus or rectum.
http://purl.obolibrary.org/obo/HP_0012733	Macule	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin.
http://purl.obolibrary.org/obo/HP_0100000	Early onset of sexual maturation	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		An early onset of puberty, in this case early does not refer to precocious.
http://purl.obolibrary.org/obo/HP_0100007	Neoplasm of the peripheral nervous system	http://purl.obolibrary.org/obo/HP_0004375	Neoplasm of the nervous system		A benign or malignant neoplasm (tumor) of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		A tumor (abnormal growth of tissue) of the breast.
http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements.
http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries.
http://purl.obolibrary.org/obo/HP_0100031	Neoplasm of the thyroid gland	http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system		A tumor (abnormal growth of tissue) of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0100037	Abnormality of the scalp hair	http://purl.obolibrary.org/obo/HP_0001965	Abnormal scalp morphology		An abnormality of the hair of head.
http://purl.obolibrary.org/obo/HP_0100039	Thickened cortex of bones	http://purl.obolibrary.org/obo/HP_0003103	Abnormal cortical bone morphology		An Abnormality of cortical bone leading to an abnormal thickness of the cortex of affected bones.
http://purl.obolibrary.org/obo/HP_0100133	Abnormality of the pubic hair	http://purl.obolibrary.org/obo/HP_0009888	Abnormality of secondary sexual hair		Abnormality of the growth of the pubic hair. Pubic hair is part of the secondary sexual hair, which normally ensues during puberty.
http://purl.obolibrary.org/obo/HP_0100134	Abnormality of the axillary hair	http://purl.obolibrary.org/obo/HP_0009888	Abnormality of secondary sexual hair		Abnormality of the growth of the axillary hair. Axillary hair is part of the secondary sexual hair, which normally ensues during puberty.
http://purl.obolibrary.org/obo/HP_0100168	Fragmented epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Fragmented appearance of the epiphyses.
http://purl.obolibrary.org/obo/HP_0100235	Toe phalanx synostosis	http://purl.obolibrary.org/obo/HP_0009140	Synostosis involving bones of the feet		Any congenital union involving toe phalanges, whether it is end-to-end (symphalangism) or side-to-side (osseous syndactyly).
http://purl.obolibrary.org/obo/HP_0100238	Synostosis involving bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0100240	Synostosis of joints		An abnormal union between bones or parts of bones of the upper limbs.
http://purl.obolibrary.org/obo/HP_0100240	Synostosis of joints	http://purl.obolibrary.org/obo/HP_0011729	Abnormality of joint mobility		The abnormal fusion of neighboring bones across a joint.
http://purl.obolibrary.org/obo/HP_0100242	Sarcoma	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.
http://purl.obolibrary.org/obo/HP_0100243	Leiomyosarcoma	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		A smooth muscle connective tissue tumor, which is rare type of cancer that is a malignant neoplasm of smooth muscle. When such a neoplasm is benign, it is called a leiomyoma.
http://purl.obolibrary.org/obo/HP_0100257	Ectrodactyly	http://purl.obolibrary.org/obo/HP_0002813	Abnormal limb bone morphology		A condition in which middle parts of the hands and/or feet (digits and meta-carpals and -tarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe/fingers over absent 2nd or 3rd toes/fingers as far as oligo- or monodactyl hands and/or feet.
http://purl.obolibrary.org/obo/HP_0100258	Preaxial polydactyly	http://purl.obolibrary.org/obo/HP_0010442	Polydactyly		A form of polydactyly in which the extra digit or digits are localized on the side of the thumb or great toe.
http://purl.obolibrary.org/obo/HP_0100259	Postaxial polydactyly	http://purl.obolibrary.org/obo/HP_0010442	Polydactyly		A form of polydactyly in which the extra digit or digits are localized on the side of the fifth finger or fifth toe.
http://purl.obolibrary.org/obo/HP_0100267	Lip pit	http://purl.obolibrary.org/obo/HP_0100276	Skin pit		A depression located on a lip.
http://purl.obolibrary.org/obo/HP_0100269	Paramedian lip pit	http://purl.obolibrary.org/obo/HP_0100267	Lip pit		Depression located paramedially on the vermilion of a lip.
http://purl.obolibrary.org/obo/HP_0100303	Muscle fiber cytoplasmatic inclusion bodies	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		The presence of inclusion bodies within the cytoplasm of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins.
http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain.
http://purl.obolibrary.org/obo/HP_0100321	Abnormal dentate nucleus morphology	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		An abnormality of the dentate nucleus.
http://purl.obolibrary.org/obo/HP_0100324	Scleroderma	http://purl.obolibrary.org/obo/HP_0001072	Thickened skin		A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin.
http://purl.obolibrary.org/obo/HP_0100326	Immunologic hypersensitivity	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		Immunological states where the immune system produces harmful responses upon reexposure to sensitizing antigens.
http://purl.obolibrary.org/obo/HP_0100336	Bilateral cleft lip	http://purl.obolibrary.org/obo/HP_0100335	Non-midline cleft of the upper lip		A non-midline cleft of the upper lip on the left and right sides.
http://purl.obolibrary.org/obo/HP_0100337	Bilateral cleft palate	http://purl.obolibrary.org/obo/HP_0100338	Non-midline cleft palate		Nonmidline cleft palate on the left and right sides.
http://purl.obolibrary.org/obo/HP_0100360	Upper-limb joint contracture	http://purl.obolibrary.org/obo/HP_0003121	Limb joint contracture		A limitation in the passive range of motion of a joint of the upper limb resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin.
http://purl.obolibrary.org/obo/HP_0100490	Camptodactyly of finger	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers cannot be extended to 180 degrees by either active or passive extension.
http://purl.obolibrary.org/obo/HP_0100523	Liver abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A localized, circumscribed collection of purulent material (pus) within the liver parenchyma, typically resulting from a bacterial, parasitic, or fungal infection. Unlike hepatitis, which is often diffuse, an abscess is a focal lesion.
http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung	http://purl.obolibrary.org/obo/HP_0100606	Neoplasm of the respiratory system		Tumor of the lung.
http://purl.obolibrary.org/obo/HP_0100529	Abnormal circulating phosphate ion concentration	http://purl.obolibrary.org/obo/HP_0020330	Abnormal circulating inorganic anion concentration		Any deviation from the normal concentration of phosphate ion in the blood circulation.
http://purl.obolibrary.org/obo/HP_0100530	Abnormal circulating calcium-phosphate regulating hormone concentration	http://purl.obolibrary.org/obo/HP_0033331	Acute phase response		Any deviation from the normal concentration in the blood circulation of a hormone that is involved in the regulation of phosphate and calcium.
http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of the eye, parts of the eye or the periorbital region.
http://purl.obolibrary.org/obo/HP_0100538	Abnormality of the supraorbital ridges	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		An anomaly of the supraorbital portion of the frontal bones.
http://purl.obolibrary.org/obo/HP_0100542	Abnormal localization of kidney	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An abnormal site of the kidney.
http://purl.obolibrary.org/obo/HP_0100543	Cognitive impairment	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		Abnormal cognition is characterized by deficits in thinking, reasoning, or remembering.
http://purl.obolibrary.org/obo/HP_0100545	Arterial stenosis	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Narrowing or constriction of the inner surface (lumen) of an artery.
http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle.
http://purl.obolibrary.org/obo/HP_0100548	Exstrophy	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		Eversion of a hollow organ and exposure, inside out, and protruded through the abdominal wall.
http://purl.obolibrary.org/obo/HP_0100555	Asymmetric growth	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		A growth pattern that displays an abnormal difference between the left and the right side.
http://purl.obolibrary.org/obo/HP_0100577	Urinary bladder inflammation	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0100579	Mucosal telangiectasiae	http://purl.obolibrary.org/obo/HP_0001009	Telangiectasia		Telangiectasia of the mucosa, the mucous membranes which are involved in absorption and secretion that line cavities that are exposed to the external environment and internal organs.
http://purl.obolibrary.org/obo/HP_0100584	Endocarditis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		An inflammation of the endocardium, the inner layer of the heart, which usually involves the heart valves.
http://purl.obolibrary.org/obo/HP_0100587	Abnormal preputium morphology	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		An abnormality of the retractable fold of skin that covers the tip of the penis.
http://purl.obolibrary.org/obo/HP_0100590	Rectal fistula	http://purl.obolibrary.org/obo/HP_0100819	Intestinal fistula		The presence of a fistula affecting the rectum.
http://purl.obolibrary.org/obo/HP_0100593	Calcification of cartilage	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		The presence of calcium deposition in cartilage.
http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm	http://purl.obolibrary.org/obo/HP_0010785	Gonadal neoplasm		A tumor (abnormal growth of tissue) of the ovary.
http://purl.obolibrary.org/obo/HP_0100627	Displacement of the urethral meatus	http://purl.obolibrary.org/obo/HP_0032076	Abnormal male urethral meatus morphology		A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina).
http://purl.obolibrary.org/obo/HP_0100634	Neuroendocrine neoplasm	http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system		A tumor that originates from a neuroendocrine cell.
http://purl.obolibrary.org/obo/HP_0100639	Erectile dysfunction	http://purl.obolibrary.org/obo/HP_0040307	Male sexual dysfunction		A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological.
http://purl.obolibrary.org/obo/HP_0100643	Abnormality of nail color	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		An anomaly of the color of the nail.
http://purl.obolibrary.org/obo/HP_0100646	Thyroiditis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0100658	Cellulitis	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		A bacterial infection and inflammation of the skin und subcutaneous tissues.
http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology	http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology		An anomaly of the cerebral blood vessels.
http://purl.obolibrary.org/obo/HP_0100660	Dyskinesia	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		A movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements.
http://purl.obolibrary.org/obo/HP_0100671	Abnormal trabecular bone morphology	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		Abnormal structure or form of trabecular bone.
http://purl.obolibrary.org/obo/HP_0100678	Premature skin wrinkling	http://purl.obolibrary.org/obo/HP_0007495	Prematurely aged appearance		The presence of an increased degree of wrinkling (irregular folds and indentations) of the skin as compared with age-related norms.
http://purl.obolibrary.org/obo/HP_0100685	Abnormal Sharpey fiber morphology	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		An abnormality of Sharpey's fibers (bone fibers, or perforating fibers), which are a matrix of connective tissue consisting of bundles of strong collagenous fibers connecting periosteum to bone.
http://purl.obolibrary.org/obo/HP_0100689	Decreased corneal thickness	http://purl.obolibrary.org/obo/HP_0011486	Abnormal corneal thickness		A decreased anteroposterior thickness of the cornea.
http://purl.obolibrary.org/obo/HP_0100692	Increased corneal curvature	http://purl.obolibrary.org/obo/HP_0100691	Abnormality of the curvature of the cornea		An increase in the degree of curvature of the cornea compared to normal.
http://purl.obolibrary.org/obo/HP_0100705	Abnormal glial cell morphology	http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology		An abnormality of the glia cell.
http://purl.obolibrary.org/obo/HP_0100711	Abnormal thoracic spine morphology	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		An abnormality of the thoracic vertebral column.
http://purl.obolibrary.org/obo/HP_0100716	Self-injurious behavior	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		Self-aggression.
http://purl.obolibrary.org/obo/HP_0100733	Neoplasm of the parathyroid gland	http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system		A tumor (abnormal growth of tissue) of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0100736	Abnormal soft palate morphology	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		An abnormality of the soft palate.
http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior	http://purl.obolibrary.org/obo/HP_0040202	Abnormal consumption behavior		Abnormal eating habits involve excessive or insufficient consumption of food, or any other abnormal pattern of food consumption.
http://purl.obolibrary.org/obo/HP_0100742	Vascular neoplasm	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A benign or malignant neoplasm (tumor) originating in the vascular system.
http://purl.obolibrary.org/obo/HP_0100745	Abnormality of the humeroulnar joint	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		An anomaly of the joint between the trochlear notch of ulna and the trochlea of humerus, which is part of the elbow joint.
http://purl.obolibrary.org/obo/HP_0100763	Abnormality of the lymphatic system	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the immune system		An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively.
http://purl.obolibrary.org/obo/HP_0100766	Abnormal lymphatic vessel morphology	http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology		A structural anomaly of the vessel that contains or conveys lymph fluid.
http://purl.obolibrary.org/obo/HP_0100777	Exostoses	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.
http://purl.obolibrary.org/obo/HP_0100800	Aplasia/Hypoplasia of the pancreas	http://purl.obolibrary.org/obo/HP_0012094	Abnormal pancreas size		A congenital underdevelopment (aplasia or hypoplasia) of the pancreas.
http://purl.obolibrary.org/obo/HP_0100803	Abnormal periungual morphology	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		An abnormality of the region around the nails of the fingers or toes.
http://purl.obolibrary.org/obo/HP_0100807	Long fingers	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		The middle finger is more than 2 SD above the mean for newborns 27 to 41 weeks EGA or above the 97th centile for children from birth to 16 years of age AND the five digits retain their normal length proportions relative to each other (i.e., it is not the case that the middle finger is the only lengthened digit), or, Fingers that appear disproportionately long compared to the palm of the hand.
http://purl.obolibrary.org/obo/HP_0100828	Increased total T cell count	http://purl.obolibrary.org/obo/HP_5210412	Increased total T cell number		Abnormal increase in the absolute number of T cells, commonly characterized as CD3+ lymphocytes, per microliter of blood, compared to a reference range for a given sex and age-group. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_0100836	Malignant neoplasm of the central nervous system	http://purl.obolibrary.org/obo/HP_0100006	Neoplasm of the central nervous system		A tumor that originates in the pineal gland, has moderate cellularity and tends to form rosette patterns.
http://purl.obolibrary.org/obo/HP_0100840	Aplasia/Hypoplasia of the eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		Absence or underdevelopment of the eyebrow.
http://purl.obolibrary.org/obo/HP_0100851	Abnormal emotional state	http://purl.obolibrary.org/obo/HP_0025766	Abnormal affect		A disturbance in the experience or expression of emotion, characterized by alterations in valence, intensity, frequency, or duration. It may also involve emotional responses that are mismatched, exaggerated, or incongruent relative to internal expectations or external contextual stimuli, such as experiencing negative affect in response to neutral or positive events.
http://purl.obolibrary.org/obo/HP_0100852	Abnormal fear-induced behavior	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		An abnormal fear-induced behavior includes observable actions. This behavior is characterized by abnormal responses to fear or abnormal fear levels. Examples of such behavior include avoiding fear-inducing situations.
http://purl.obolibrary.org/obo/HP_0100854	Aplasia of the musculature	http://purl.obolibrary.org/obo/HP_0001460	Aplasia/Hypoplasia involving the skeletal musculature		Absence of the musculature.
http://purl.obolibrary.org/obo/HP_0100871	Abnormal palm morphology	http://purl.obolibrary.org/obo/HP_0001155	Abnormality of the hand		An abnormality of the palm, that is, of the front of the hand.
http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		An abnormality of the plantar part of foot, that is of the soles of the feet.
http://purl.obolibrary.org/obo/HP_0100886	Abnormality of globe location	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		An abnormality in the placement of the ocular globe (eyeball).
http://purl.obolibrary.org/obo/HP_0100887	Abnormality of globe size	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		An abnormality in the size of the ocular globe (eyeball).
http://purl.obolibrary.org/obo/HP_0100957	Abnormal renal medulla morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Any structural abnormality of the medulla of the kidney.
http://purl.obolibrary.org/obo/HP_0200007	Abnormal size of the palpebral fissures	http://purl.obolibrary.org/obo/HP_0008050	Abnormality of the palpebral fissures		An abnormal size of the palpebral fissures for example unusually long or short palpebral fissures.
http://purl.obolibrary.org/obo/HP_0200020	Corneal erosion	http://purl.obolibrary.org/obo/HP_0011495	Abnormal corneal epithelium morphology		An erosion or abrasion of the cornea's outermost layer of epithelial cells.
http://purl.obolibrary.org/obo/HP_0200024	Premature chromatid separation	http://purl.obolibrary.org/obo/HP_0002916	Abnormality of chromosome segregation		The presence of premature sister chromatid segregation.
http://purl.obolibrary.org/obo/HP_0200036	Skin nodule	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat.
http://purl.obolibrary.org/obo/HP_0200042	Skin ulcer	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat.
http://purl.obolibrary.org/obo/HP_0200114	Metabolic alkalosis	http://purl.obolibrary.org/obo/HP_0001948	Alkalosis		Metabolic alkalosis is defined as a disease state where the pH is elevated to greater than 7.45 secondary to some metabolic process.
http://purl.obolibrary.org/obo/UBERON_0000002	uterine cervix	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Lower, narrow portion of the uterus where it joins with the top end of the vagina.
http://purl.obolibrary.org/obo/UBERON_0000004	nose	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity.
http://purl.obolibrary.org/obo/UBERON_0000017	exocrine pancreas	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO].
http://purl.obolibrary.org/obo/UBERON_0000021	cutaneous appendage	http://purl.obolibrary.org/obo/UBERON_0013703	integumentary projection		Anatomical projection that protrudes from the skin. Examples: hair, nail, feather, claw, hoof, horn, wattle, spur, beak, antler, bristle and some scales.
http://purl.obolibrary.org/obo/UBERON_0000033	head	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		The head is the anterior-most division of the body [GO].
http://purl.obolibrary.org/obo/UBERON_0000057	urethra	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening.
http://purl.obolibrary.org/obo/UBERON_0000079	male reproductive system	http://purl.obolibrary.org/obo/UBERON_0000990	reproductive system		The organs associated with producing offspring in the gender that produces spermatozoa.
http://purl.obolibrary.org/obo/UBERON_0000304	tendon sheath	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath.
http://purl.obolibrary.org/obo/UBERON_0000382	apocrine sweat gland	http://purl.obolibrary.org/obo/UBERON_0012177	skin apocrine gland		Apocrine sweat glands are sweat glands composed of a coiled secretory portion located at the junction of the dermis and subcutaneous fat, from which a straight portion inserts and secretes into the infundibular portion of the hair follicle. The ducts of apocrine glands open into the canals of hair follicles. The stimulus for the secretion of apocrine sweat glands is adrenaline, which is a hormone carried in the blood[WP].
http://purl.obolibrary.org/obo/UBERON_0000388	epiglottis	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		A part of the pharynx that consists of a flap of elastic cartilage tissue plus a mucous membrane covering, attached to the entrance of the larynx. The epiglottis is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink[MP,modified].
http://purl.obolibrary.org/obo/UBERON_0000391	leptomeninx	http://purl.obolibrary.org/obo/UBERON_0002360	meninx		Pia mater or arachnoid mater.
http://purl.obolibrary.org/obo/UBERON_0000402	nasal vestibule	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The nasal vestibule is the most anterior part of the nasal cavity. It's enclosed by the cartilages of nose and lined by the same epithelium of the skin. The other part of the nasal cavity, which is lined by the respiratory epithelium, is called nasal cavity proper. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0000403	scalp	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendonous galea aponeurotica; Loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).
http://purl.obolibrary.org/obo/UBERON_0000423	eccrine sweat gland	http://purl.obolibrary.org/obo/UBERON_0010243	merocrine gland		A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion.
http://purl.obolibrary.org/obo/UBERON_0000458	endocervix	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The region of the opening of the uterine cervix into the uterine cavity.
http://purl.obolibrary.org/obo/UBERON_0000473	testis	http://purl.obolibrary.org/obo/UBERON_0003135	male reproductive organ		A gonad of a male animal. A gonad produces and releases sperm.
http://purl.obolibrary.org/obo/UBERON_0000474	female reproductive system	http://purl.obolibrary.org/obo/UBERON_0000990	reproductive system		The organs and associated structures associated with bearing offspring in a female animal.
http://purl.obolibrary.org/obo/UBERON_0000915	thoracic segment of trunk	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		Subdivision of trunk that lies between the head and the abdomen.
http://purl.obolibrary.org/obo/UBERON_0000946	cardiac valve	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		A membranous fold of the heart that prevents reflux of fluid.
http://purl.obolibrary.org/obo/UBERON_0000947	aorta	http://purl.obolibrary.org/obo/UBERON_0013768	great vessel of heart		The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation.
http://purl.obolibrary.org/obo/UBERON_0000959	optic chiasma	http://purl.obolibrary.org/obo/UBERON_0007425	decussation of diencephalon		A decussation of the diencephalon where the fibers of the optic nerve cross.
http://purl.obolibrary.org/obo/UBERON_0000974	neck	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column.
http://purl.obolibrary.org/obo/UBERON_0000975	sternum	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		A midventral endochondral skeletal element which represents the origin site of the pectoral muscles[PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0000991	gonad	http://purl.obolibrary.org/obo/UBERON_0003133	reproductive organ		Reproductive organ that produces and releases eggs (ovary) or sperm (testis).
http://purl.obolibrary.org/obo/UBERON_0001003	skin epidermis	http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure		The outer epithelial layer of the skin that is superficial to the dermis.
http://purl.obolibrary.org/obo/UBERON_0001007	digestive system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.
http://purl.obolibrary.org/obo/UBERON_0001008	renal system	http://purl.obolibrary.org/obo/UBERON_8450002	excretory system		The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.
http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair	http://purl.obolibrary.org/obo/UBERON_0000021	cutaneous appendage		A filament, mostly protein, that grows from follicles found in the dermis[WP].
http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0002385	muscle tissue		Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO].
http://purl.obolibrary.org/obo/UBERON_0001161	body of stomach	http://purl.obolibrary.org/obo/UBERON_0009870	zone of stomach		The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO].
http://purl.obolibrary.org/obo/UBERON_0001173	biliary tree	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder.
http://purl.obolibrary.org/obo/UBERON_0001174	common bile duct	http://purl.obolibrary.org/obo/UBERON_0003703	extrahepatic bile duct		The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct.
http://purl.obolibrary.org/obo/UBERON_0001182	superior mesenteric artery	http://purl.obolibrary.org/obo/UBERON_0005616	mesenteric artery		Mesenteric artery that supplies the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0001224	renal pelvis	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP].
http://purl.obolibrary.org/obo/UBERON_0001232	collecting duct of renal tubule	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient.
http://purl.obolibrary.org/obo/UBERON_0001235	adrenal cortex	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone.
http://purl.obolibrary.org/obo/UBERON_0001236	adrenal medulla	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine.
http://purl.obolibrary.org/obo/UBERON_0001264	pancreas	http://purl.obolibrary.org/obo/UBERON_0002075	viscus		An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO].
http://purl.obolibrary.org/obo/UBERON_0001267	femoral nerve	http://purl.obolibrary.org/obo/UBERON_0003431	leg nerve		The femoral nerve, the largest branch of the lumbar plexus, arises from the ventral divisions of the second, third, and fourth lumbar nerves. It descends through the fibers of the Psoas major, emerging from the muscle at the lower part of its lateral border, and passes down between it and the Iliacus, behind the iliac fascia; it then runs beneath the inguinal ligament, into the thigh, and splits into an anterior and a posterior division. Under the inguinal ligament, it is separated from the femoral artery by a portion of the Psoas major. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001456	face	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc).
http://purl.obolibrary.org/obo/UBERON_0001557	upper respiratory tract	http://purl.obolibrary.org/obo/UBERON_0000072	proximo-distal subdivision of respiratory tract		The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea.
http://purl.obolibrary.org/obo/UBERON_0001585	anterior vena cava	http://purl.obolibrary.org/obo/UBERON_0004087	vena cava		A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart.
http://purl.obolibrary.org/obo/UBERON_0001601	extra-ocular muscle	http://purl.obolibrary.org/obo/UBERON_0010959	craniocervical muscle		Skeletal muscle derived from cranial mesoderm and controls eye movements.
http://purl.obolibrary.org/obo/UBERON_0001621	coronary artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		An artery that supplies the myocardium.
http://purl.obolibrary.org/obo/UBERON_0001633	basilar artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain.
http://purl.obolibrary.org/obo/UBERON_0001638	vein	http://purl.obolibrary.org/obo/UBERON_0003920	venous blood vessel		Any of the tubular branching vessels that carry blood from the capillaries toward the heart.
http://purl.obolibrary.org/obo/UBERON_0001643	oculomotor nerve	http://purl.obolibrary.org/obo/UBERON_0001785	cranial nerve		Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles.
http://purl.obolibrary.org/obo/UBERON_0001645	trigeminal nerve	http://purl.obolibrary.org/obo/UBERON_0001785	cranial nerve		Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).
http://purl.obolibrary.org/obo/UBERON_0001647	facial nerve	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches).
http://purl.obolibrary.org/obo/UBERON_0001649	glossopharyngeal nerve	http://purl.obolibrary.org/obo/UBERON_0001785	cranial nerve		Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult).
http://purl.obolibrary.org/obo/UBERON_0001679	ethmoid bone	http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone		A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP].
http://purl.obolibrary.org/obo/UBERON_0001684	mandible	http://purl.obolibrary.org/obo/UBERON_0004742	dentary		A dentary bone that is the only bone in one of the lateral halves of the lower jaw skeleton.
http://purl.obolibrary.org/obo/UBERON_0001691	external ear	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Part of the ear external to the tympanum (eardrum). It typically consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO].
http://purl.obolibrary.org/obo/UBERON_0001728	nasopharynx	http://purl.obolibrary.org/obo/UBERON_0000072	proximo-distal subdivision of respiratory tract		The section of the pharynx that lies above the soft palate.
http://purl.obolibrary.org/obo/UBERON_0001732	pharyngeal tonsil	http://purl.obolibrary.org/obo/UBERON_0012330	nasal-associated lymphoid tissue		The lymph tissue in the roof and posterior wall of the nasopharynx.
http://purl.obolibrary.org/obo/UBERON_0001733	soft palate	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		The muscular, non-bony arch-shaped posterior portion of the palate extending from the posterior edge of the hard palate.
http://purl.obolibrary.org/obo/UBERON_0001734	palatine uvula	http://purl.obolibrary.org/obo/UBERON_0004529	anatomical projection		Conic projection from the posterior edge of the middle of the soft palate, composed of connective tissue containing a number of racemose glands, and some muscular fibers.
http://purl.obolibrary.org/obo/UBERON_0001735	tonsillar ring	http://purl.obolibrary.org/obo/UBERON_0001962	gut-associated lymphoid tissue		The circular lymphoid tissue formed by the lingual, pharyngeal, and faucial tonsils.
http://purl.obolibrary.org/obo/UBERON_0001754	dental pulp	http://purl.obolibrary.org/obo/UBERON_0011825	loose connective tissue		The part in the center of a tooth made up of living soft tissue and cells called odontoblasts[WP].
http://purl.obolibrary.org/obo/UBERON_0001757	pinna	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		The part of the ear that projects from the head, connecting to the external acoustic meatus.
http://purl.obolibrary.org/obo/UBERON_0001768	uvea	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited].
http://purl.obolibrary.org/obo/UBERON_0001769	iris	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye.
http://purl.obolibrary.org/obo/UBERON_0001771	pupil	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The central circular aperture of the iris through which light rays enter the eye.
http://purl.obolibrary.org/obo/UBERON_0001775	ciliary body	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes.
http://purl.obolibrary.org/obo/UBERON_0001785	cranial nerve	http://purl.obolibrary.org/obo/UBERON_0034713	cranial neuron projection bundle		Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord.
http://purl.obolibrary.org/obo/UBERON_0001797	vitreous humor	http://purl.obolibrary.org/obo/UBERON_0006312	ocular refractive media		A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina.
http://purl.obolibrary.org/obo/UBERON_0001814	brachial nerve plexus	http://purl.obolibrary.org/obo/UBERON_0001813	spinal nerve plexus		An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001817	lacrimal gland	http://purl.obolibrary.org/obo/UBERON_0015154	lateral gland of orbital region		The lacrimal glands are paired almond-shaped glands, located in or near the orbital region, that secrete the aqueous layer of the tear film.[WP].
http://purl.obolibrary.org/obo/UBERON_0001821	sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0019319	exocrine gland of integumental system		A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP].
http://purl.obolibrary.org/obo/UBERON_0001828	gingiva	http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa		The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001].
http://purl.obolibrary.org/obo/UBERON_0001832	sublingual gland	http://purl.obolibrary.org/obo/UBERON_0001829	major salivary gland		The small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland.
http://purl.obolibrary.org/obo/UBERON_0001834	upper lip	http://purl.obolibrary.org/obo/UBERON_0001833	lip		Lip that covers the upper portion of the mouth.[TAO].
http://purl.obolibrary.org/obo/UBERON_0001835	lower lip	http://purl.obolibrary.org/obo/UBERON_0001833	lip		Lip that covers the lower portion of the mouth.[TAO].
http://purl.obolibrary.org/obo/UBERON_0001846	internal ear	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation.
http://purl.obolibrary.org/obo/UBERON_0001869	cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA].
http://purl.obolibrary.org/obo/UBERON_0001871	temporal lobe	http://purl.obolibrary.org/obo/UBERON_0016526	lobe of cerebral hemisphere		Lower lateral part of the cerebral hemisphere. (MSH).
http://purl.obolibrary.org/obo/UBERON_0001886	choroid plexus	http://purl.obolibrary.org/obo/UBERON_0036303	vasculature of central nervous system		A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces.
http://purl.obolibrary.org/obo/UBERON_0001893	telencephalon	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.
http://purl.obolibrary.org/obo/UBERON_0001894	diencephalon	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		The division of the forebrain that develops from the foremost primary cerebral vesicle.
http://purl.obolibrary.org/obo/UBERON_0001905	pineal body	http://purl.obolibrary.org/obo/UBERON_0010134	secretory circumventricular organ		A midline, cone like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures. The stalk contains nerve fibers, blood vessels, connective tissue and parenchymal cells (Paxinos, The Rat Central Nervous System, 2nd ed, pg 399).
http://purl.obolibrary.org/obo/UBERON_0001908	optic tract	http://purl.obolibrary.org/obo/UBERON_0011591	tract of diencephalon		Diencephalic white matter (tract) which is comprised of retinal ganglion cell axons after which they have passed through the optic chiasm[ZFA]. Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM)[NIF].
http://purl.obolibrary.org/obo/UBERON_0001987	placenta	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell.
http://purl.obolibrary.org/obo/UBERON_0002016	pulmonary vein	http://purl.obolibrary.org/obo/UBERON_0013768	great vessel of heart		Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO].
http://purl.obolibrary.org/obo/UBERON_0002019	accessory XI nerve	http://purl.obolibrary.org/obo/UBERON_0035642	laryngeal nerve		A cranial nerve that originates from neurons in the medulla and in the cervical spinal cord.
http://purl.obolibrary.org/obo/UBERON_0002030	nipple	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Projection of skin containing the outlets for 15-20 lactiferous ducts arranged cylindrically around the tip.
http://purl.obolibrary.org/obo/UBERON_0002037	cerebellum	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA].
http://purl.obolibrary.org/obo/UBERON_0002067	dermis	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].
http://purl.obolibrary.org/obo/UBERON_0002135	mitral valve	http://purl.obolibrary.org/obo/UBERON_0002133	atrioventricular valve		An atrioventricular valve that is part of the outflow part of the left atrium.
http://purl.obolibrary.org/obo/UBERON_0002137	aortic valve	http://purl.obolibrary.org/obo/UBERON_0005623	semi-lunar valve		Cardiac valve which has as its parts the anterior, right posterior and left posterior cusps, attached to the fibrous ring of aortic valve.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002146	pulmonary valve	http://purl.obolibrary.org/obo/UBERON_0005623	semi-lunar valve		The semilunar valve of the heart that lies between the right ventricle and the pulmonary artery.
http://purl.obolibrary.org/obo/UBERON_0002198	neurohypophysis	http://purl.obolibrary.org/obo/UBERON_0010134	secretory circumventricular organ		The posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormon.
http://purl.obolibrary.org/obo/UBERON_0002285	telencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0004086	brain ventricle		A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002286	third ventricle	http://purl.obolibrary.org/obo/UBERON_0004086	brain ventricle		Part of the ventricular system of the brain, forming a single large cavity in the midline of the diencephalon; it is continuous with the lateral ventricles through the interventricular foramen and the fourth ventricle through the cerebral aqueduct. (Maryann Martone).
http://purl.obolibrary.org/obo/UBERON_0002348	epicardium	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart.
http://purl.obolibrary.org/obo/UBERON_0002349	myocardium	http://purl.obolibrary.org/obo/UBERON_0018260	layer of muscle tissue		The middle layer of the heart, comprised mainly of striated cardiac muscle fibers.
http://purl.obolibrary.org/obo/UBERON_0002364	tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0000094	membrane organ		A thin membrane that separates the external ear from the middle ear, consisting of two epithelia (one part of the the external accoustic meatus epithelium, the other part of the tympanic cavity epithelium) with a fibrous layer between them. Its function is to transmit sound from the air to the ossicles inside the middle ear. The malleus bone bridges the gap between the eardrum and the other ossicles. Rupture or perforation of the eardrum can lead to conductive hearing loss. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002369	adrenal gland	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO].
http://purl.obolibrary.org/obo/UBERON_0002371	bone marrow	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		The soft tissue that fills the cavities of bones.
http://purl.obolibrary.org/obo/UBERON_0002385	muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].
http://purl.obolibrary.org/obo/UBERON_0002386	forelimb zeugopod	http://purl.obolibrary.org/obo/UBERON_0008785	upper limb segment		The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants.
http://purl.obolibrary.org/obo/UBERON_0002390	hematopoietic system	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		Anatomical system that is involved in the production of hematopoietic cells.
http://purl.obolibrary.org/obo/UBERON_0002411	clitoris	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The small, erectile body located at the anterior end of the vulva.
http://purl.obolibrary.org/obo/UBERON_0002420	basal ganglion	http://purl.obolibrary.org/obo/UBERON_0007245	nuclear complex of neuraxis		An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified].
http://purl.obolibrary.org/obo/UBERON_0002486	glottis	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		The vocal apparatus of the larynx, which includes the vocal cords and the opening between them.
http://purl.obolibrary.org/obo/UBERON_0003074	mesonephric duct	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA].
http://purl.obolibrary.org/obo/UBERON_0003129	skull	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP].
http://purl.obolibrary.org/obo/UBERON_0003216	hard palate	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Anterior portion of the palate consisting of bone and mucous membranes [GO]. The hard palate is formed from bony processes of the maxilla, premaxilla and palatine bone [Kardong].
http://purl.obolibrary.org/obo/UBERON_0003292	meninx of spinal cord	http://purl.obolibrary.org/obo/UBERON_0005174	dorsal region element		A meninx that is part of a spinal cord [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003679	mouth floor	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		The ventral area of the mouth. In organisms with a tongue, this is the area under the ventral surface of the tongue[ncit, modified].
http://purl.obolibrary.org/obo/UBERON_0003687	foramen magnum	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0003704	intrahepatic bile duct	http://purl.obolibrary.org/obo/UBERON_0002394	bile duct		Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
http://purl.obolibrary.org/obo/UBERON_0003712	cavernous sinus	http://purl.obolibrary.org/obo/UBERON_0005486	venous dural sinus		The cavernous sinus (or lateral sellar compartment), within the human head, is a large collection of thin-walled veins creating a cavity bordered by the temporal bone of the skull and the sphenoid bone, lateral to the sella turcica.
http://purl.obolibrary.org/obo/UBERON_0004086	brain ventricle	http://purl.obolibrary.org/obo/UBERON_0005358	ventricle of nervous system		One of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid.
http://purl.obolibrary.org/obo/UBERON_0004108	clivus of occipital bone	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		Part of the cranium, the clivus is a shallow depression behind the dorsum sellC& that slopes obliquely backward. It forms a gradual sloping process at the anterior most portion of the basilar occipital bone at its junction with the sphenoid bone. On axial planes, it sits just posterior to the sphenoid sinuses. Just lateral to the clivus bilaterally is the foramen lacerum which contains the internal carotid artery, proximal to its anastamosis with the Circle of Willis. Posterior to the clivus is the basilar artery. The clivus supports the upper part of the pons.
http://purl.obolibrary.org/obo/UBERON_0004363	pharyngeal arch artery	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].
http://purl.obolibrary.org/obo/UBERON_0004681	vestibular system	http://purl.obolibrary.org/obo/UBERON_0001032	sensory system		The sensory system for the sense of balance.
http://purl.obolibrary.org/obo/UBERON_0004720	cerebellar vermis	http://purl.obolibrary.org/obo/UBERON_0002749	regional part of cerebellar cortex		A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally).
http://purl.obolibrary.org/obo/UBERON_0005396	carotid artery segment	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		One of: the common carotid artery, or its branches, the external and internal carotid arteries.
http://purl.obolibrary.org/obo/UBERON_0005456	jugular foramen	http://purl.obolibrary.org/obo/UBERON_0018321	foramen for glossopharyngeal nerve		The jugular foramen is a large aperture in the base of the skull. It is located behind the carotid canal and is formed in front by the petrous portion of the temporal, and behind by the occipital; it is generally larger on the right than on the left side.
http://purl.obolibrary.org/obo/UBERON_0006052	digit 5	http://purl.obolibrary.org/obo/UBERON_0019221	digit 1 or 5		A digit that is part of a digit 5 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0006059	falx cerebri	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The falx cerebri, also known as the cerebral falx, so named from its sickle-like form, is a strong, arched fold of dura mater which descends vertically in the longitudinal fissure between the cerebral hemispheres. It is narrow in front, where it is attached to the crista galli of the ethmoid; and broad behind, where it is connected with the upper surface of the tentorium cerebelli. Its upper margin is convex, and attached to the inner surface of the skull in the middle line, as far back as the internal occipital protuberance; it contains the superior sagittal sinus. Its lower margin is free and concave, and contains the inferior sagittal sinus. The falx cerebri is known to calcify with age.
http://purl.obolibrary.org/obo/UBERON_0006956	buccal mucosa	http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa		The inner lining of the cheeks and lips.
http://purl.obolibrary.org/obo/UBERON_0007329	pancreatic duct	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		A duct that collects and carries secretions of the exocrine pancreas to the intestine.
http://purl.obolibrary.org/obo/UBERON_0007616	layer of synovial tissue	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO].
http://purl.obolibrary.org/obo/UBERON_0007798	vascular system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Anatomical system that consists of all blood and lymph vessels.
http://purl.obolibrary.org/obo/UBERON_0008788	posterior cranial fossa	http://purl.obolibrary.org/obo/UBERON_0008789	cranial fossa		The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE.
http://purl.obolibrary.org/obo/UBERON_0008883	osteoid	http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue		Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue.
http://purl.obolibrary.org/obo/UBERON_0008974	apocrine gland	http://purl.obolibrary.org/obo/UBERON_0002365	exocrine gland		Any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk.
http://purl.obolibrary.org/obo/UBERON_0010743	meningeal cluster	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		The collection of all meningeal layers that line a central nervous system.
http://purl.obolibrary.org/obo/UBERON_0010996	articular cartilage of joint	http://purl.obolibrary.org/obo/UBERON_0001994	hyaline cartilage tissue		A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints.
http://purl.obolibrary.org/obo/UBERON_0014385	aryepiglottic fold	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The entrance of the larynx is a triangular opening, narrow in front, wide behind, and sloping obliquely downward and backward. It is bounded, in front, by the epiglottis; behind, by the apices of the arytenoid cartilages, the corniculate cartilages, and the interarytenoid notch; and on either side, by a fold of mucous membrane, enclosing ligamentous and muscular fibers, stretched between the side of the epiglottis and the apex of the arytenoid cartilage; this is the aryepiglottic fold, on the posterior part of the margin of which the cuneiform cartilage forms a more or less distinct whitish prominence, the cuneiform tubercle. These folds form the upper borders of the quadrangular membrane.
http://purl.obolibrary.org/obo/UBERON_0016490	auditory system	http://purl.obolibrary.org/obo/UBERON_0007037	mechanosensory system		Is the sensory system for the sense of hearing.
http://purl.obolibrary.org/obo/UBERON_0018707	bladder organ	http://purl.obolibrary.org/obo/UBERON_0009856	sac		A membranous sac in animals that serves as the receptacle of a liquid or contains gas.
http://purl.obolibrary.org/obo/PATO_0000047	biological sex	http://purl.obolibrary.org/obo/PATO_0001995	organismal quality		An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved.
http://purl.obolibrary.org/obo/PATO_0000122	length	http://purl.obolibrary.org/obo/PATO_0001708	1-D extent		A 1-D extent quality which is equal to the distance between two points.
http://purl.obolibrary.org/obo/PATO_0000125	mass	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.
http://purl.obolibrary.org/obo/PATO_0000186	behavioral quality	http://purl.obolibrary.org/obo/PATO_0001995	organismal quality		An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation.
http://purl.obolibrary.org/obo/PATO_0000918	volume	http://purl.obolibrary.org/obo/PATO_0001710	3-D extent		A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies.
http://purl.obolibrary.org/obo/PATO_0001025	pressure	http://purl.obolibrary.org/obo/PATO_0001018	physical quality		A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts.
http://purl.obolibrary.org/obo/PATO_0001167	damaged	http://purl.obolibrary.org/obo/PATO_0001020	damage		A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired.
http://purl.obolibrary.org/obo/PATO_0001374	ploidy	http://purl.obolibrary.org/obo/PATO_0001396	cellular quality		A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism.
http://purl.obolibrary.org/obo/PATO_0001375	haploid	http://purl.obolibrary.org/obo/PATO_0001393	euploid		A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes.
http://purl.obolibrary.org/obo/PATO_0001377	polyploid	http://purl.obolibrary.org/obo/PATO_0001393	euploid		A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes.
http://purl.obolibrary.org/obo/PATO_0001394	diploid	http://purl.obolibrary.org/obo/PATO_0001393	euploid		A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father.
http://purl.obolibrary.org/obo/PATO_0001396	cellular quality	http://purl.obolibrary.org/obo/PATO_0070044	anatomical structure quality		A monadic quality of continuant that exists at the cellular level of organisation.
http://purl.obolibrary.org/obo/PATO_0001546	quality of a solid	http://purl.obolibrary.org/obo/PATO_0002198	quality of a substance		A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable.
http://purl.obolibrary.org/obo/PATO_0001547	quality of a gas	http://purl.obolibrary.org/obo/PATO_0002198	quality of a substance		A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape.
http://purl.obolibrary.org/obo/PATO_0001548	quality of a liquid	http://purl.obolibrary.org/obo/PATO_0002198	quality of a substance		A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape.
http://purl.obolibrary.org/obo/PATO_0001793	right side of	http://purl.obolibrary.org/obo/PATO_0000140	position		A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity.
http://purl.obolibrary.org/obo/PATO_0001995	organismal quality	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		A quality that inheres in an entire organism or part of an organism.
http://purl.obolibrary.org/obo/PR_000000001	protein	http://purl.obolibrary.org/obo/PR_000018263	amino acid chain		An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
http://purl.obolibrary.org/obo/PR_000001004	CD4 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence.
http://purl.obolibrary.org/obo/PR_000001018	CD3 subunit with immunoglobulin domain	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response.
http://purl.obolibrary.org/obo/PR_000025402	T cell receptor co-receptor CD8	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A protein-containing complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction.
http://purl.obolibrary.org/obo/HP_3000071	Abnormality of levator labii superioris	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a levator labii superioris.
http://purl.obolibrary.org/obo/GO_0140014	mitotic nuclear division	http://purl.obolibrary.org/obo/GO_1903047	mitotic cell cycle process		A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
http://purl.obolibrary.org/obo/CL_0001061	abnormal cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models.
http://purl.obolibrary.org/obo/CL_0001063	neoplastic cell	http://purl.obolibrary.org/obo/CL_0001061	abnormal cell		An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism.
http://purl.obolibrary.org/obo/CL_0001064	malignant cell	http://purl.obolibrary.org/obo/CL_0001063	neoplastic cell		A neoplastic cell that is capable of entering a surrounding tissue
http://purl.obolibrary.org/obo/CL_0001067	group 1 innate lymphoid cell	http://purl.obolibrary.org/obo/CL_0001065	innate lymphoid cell		An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.
http://purl.obolibrary.org/obo/GO_0120036	plasma membrane bounded cell projection organization	http://purl.obolibrary.org/obo/GO_0030030	cell projection organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.
http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the spleen		Any anomaly of the structure of the spleen.
http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology	http://purl.obolibrary.org/obo/HP_0001600	Abnormality of the larynx		Any anomaly of the structure of the larynx.
http://purl.obolibrary.org/obo/HP_0025424	Abnormal larynx physiology	http://purl.obolibrary.org/obo/HP_0001600	Abnormality of the larynx		Any anomaly of the function of the larynx.
http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology	http://purl.obolibrary.org/obo/HP_0005607	Abnormal tracheobronchial morphology		Any structural anomaly of the bronchi, i.e., of the airways leading from the trachea to the lungs.
http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		Any deviation from the normal range of concentration of a metabolite in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology	http://purl.obolibrary.org/obo/HP_0000014	Abnormality of the bladder		Any structural anomaly of the bladder.
http://purl.obolibrary.org/obo/HP_0025523	Abnormal morphology of the chordae tendinae of the mitral valve	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		A structural anomaly of the chordae tendinae of the mitral valve, whose main function is to transmit the contraction and relaxation of the papillary muscles during the cardiac cycle, thus ensuring the closing of the leaflets of the mitral valve.
http://purl.obolibrary.org/obo/HP_0030962	Abnormal morphology of the great vessels	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		A structural anomaly affecting a blood vessel involved in the circulation of the heart, i.e., the superior or inferior vena cava, the pulmonary arteries, the pulmonary veins, and the aorta.
http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology	http://purl.obolibrary.org/obo/HP_0004414	Abnormality of the pulmonary artery		An abnormality of the structure of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0030967	Abnormal pulmonary artery physiology	http://purl.obolibrary.org/obo/HP_0004414	Abnormality of the pulmonary artery		An abnormality of the function of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0030968	Abnormal pulmonary vein morphology	http://purl.obolibrary.org/obo/HP_0011718	Abnormality of the pulmonary veins		An abnormality of the structure of the pulmonary veins.
http://purl.obolibrary.org/obo/HP_0031013	Ankylosis	http://purl.obolibrary.org/obo/HP_0001376	Limitation of joint mobility		A reduction of joint mobility resulting from changes involving the articular surfaces.
http://purl.obolibrary.org/obo/HP_0031047	Paraproteinemia	http://purl.obolibrary.org/obo/HP_0010702	Increased circulating immunoglobulin concentration		An abnormal immunoglobulin or part of an Ig (light chain) in the circulation. Paraproteins are typically produced by a clonal population of B-cell derived plasma cells.
http://purl.obolibrary.org/obo/HP_0031051	Tarsal sclerosis	http://purl.obolibrary.org/obo/HP_0100925	Sclerosis of foot bone		An elevation in bone density in one or more tarsal bones of the foot. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0031055	Abnormal branching pattern of left aortic arch	http://purl.obolibrary.org/obo/HP_0011587	Abnormal branching pattern of the aortic arch		A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries, whereby the aortic arch descends on the left as normal (as opposed to right aortic arch).
http://purl.obolibrary.org/obo/HP_0031066	Abnormal ovarian physiology	http://purl.obolibrary.org/obo/HP_0030012	Abnormal female reproductive system physiology		Any anomaly of ovarian function.
http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology	http://purl.obolibrary.org/obo/HP_0040070	Abnormal upper limb bone morphology		Any structural anomaly of the structure of the humerus (i.e., upper arm bone).
http://purl.obolibrary.org/obo/HP_0031137	Storage in hepatocytes	http://purl.obolibrary.org/obo/HP_0034644	Abnormal liver metabolite concentration		Hepatocytes (liver parenchymal cells) exhibit a bloated appearance because of expansion of the cytoplasm by accumulated material.
http://purl.obolibrary.org/obo/HP_0410030	Cleft lip	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		A gap in the lip or lips.
http://purl.obolibrary.org/obo/HP_0500030	Abnormal hepatic glycogen storage	http://purl.obolibrary.org/obo/HP_0031137	Storage in hepatocytes		Change in normal glycogen storage content.
http://purl.obolibrary.org/obo/HP_0410035	Abnormal T cell activation	http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology		Any abnormality in the activation of T cells, i.e. the change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
http://purl.obolibrary.org/obo/PATO_0045057	normal perimeter	http://purl.obolibrary.org/obo/PATO_0045054	normal length		A perimeter which is relatively normal or average
http://purl.obolibrary.org/obo/GO_0062013	positive regulation of small molecule metabolic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.
http://purl.obolibrary.org/obo/GO_0062014	negative regulation of small molecule metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.
http://purl.obolibrary.org/obo/GO_0140238	presynaptic endocytosis	http://purl.obolibrary.org/obo/GO_0099003	vesicle-mediated transport in synapse		A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
http://purl.obolibrary.org/obo/HP_0032012	Heterotropia	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		Manifest deviation of the visual axes not controlled by fusion.
http://purl.obolibrary.org/obo/HP_0034159	Pagetic bone lesion	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		Paget's disease of bone (PDB) is a chronic progressive metabolic bone disease characterized by abnormal activation of osteoclasts that results in abnormal bone resorption and compensatory osteogenic sclerosis. DB can affect one (monostotic form) or more (polyostotic form) regions of the skeleton, with multiple constitutive symptoms, including bone pain, bone deformity, pathological fracture, tinnitus, hearing loss, vision loss, and osteoarthritis.
http://purl.obolibrary.org/obo/HP_0034160	Abnormal circulating interleukin 9 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 9 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034161	Reduced circulating interleukin 9 concentration	http://purl.obolibrary.org/obo/HP_0034160	Abnormal circulating interleukin 9 concentration		An abnormally decreased concentration of interleukin 9 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034162	Abnormal circulating interleukin 10 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 10 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034163	Reduced circulating interleukin 10 concentration	http://purl.obolibrary.org/obo/HP_0034162	Abnormal circulating interleukin 10 concentration		An abnormally decreased concentration of interleukin 10 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034164	Abnormal circulating interleukin 21 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 21 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034165	Reduced circulating interleukin 21 concentration	http://purl.obolibrary.org/obo/HP_0034164	Abnormal circulating interleukin 21 concentration		An abnormally decreased concentration of interleukin 21 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034166	Increased circulating interleukin 21 concentration	http://purl.obolibrary.org/obo/HP_0034164	Abnormal circulating interleukin 21 concentration		An abnormally increased concentration of interleukin 21 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034167	Abnormal circulating interleukin 22 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 22 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034168	Reduced circulating interleukin 22 concentration	http://purl.obolibrary.org/obo/HP_0034167	Abnormal circulating interleukin 22 concentration		An abnormally decreased concentration of interleukin 22 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034169	Increased circulating interleukin 22 concentration	http://purl.obolibrary.org/obo/HP_0034167	Abnormal circulating interleukin 22 concentration		An abnormally increased concentration of interleukin 22 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034170	Abnormal circulating interleukin 23 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 23 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034171	Reduced circulating interleukin 23 concentration	http://purl.obolibrary.org/obo/HP_0034170	Abnormal circulating interleukin 23 concentration		An abnormally decreased concentration of interleukin 23 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034172	Increased circulating interleukin 23 concentration	http://purl.obolibrary.org/obo/HP_0034170	Abnormal circulating interleukin 23 concentration		An abnormally increased concentration of interleukin 23 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034173	Abnormal circulating interleukin 27 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 27 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034174	Reduced circulating interleukin 27 concentration	http://purl.obolibrary.org/obo/HP_0034173	Abnormal circulating interleukin 27 concentration		An abnormally decreased concentration of interleukin 27 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034175	Increased circulating interleukin 27 concentration	http://purl.obolibrary.org/obo/HP_0034173	Abnormal circulating interleukin 27 concentration		An abnormally increased concentration of interleukin 27 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034176	Abnormal circulating interleukin 17A concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 17A in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034177	Reduced circulating interleukin 17A concentration	http://purl.obolibrary.org/obo/HP_0034176	Abnormal circulating interleukin 17A concentration		An abnormally decreased concentration of interleukin 17A in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034178	Increased circulating interleukin 17A concentration	http://purl.obolibrary.org/obo/HP_0034176	Abnormal circulating interleukin 17A concentration		An abnormally increased concentration of interleukin 17A in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034179	Vertebral artery aneurysm	http://purl.obolibrary.org/obo/HP_0030321	Abnormal vertebral artery morphology		Abnormal outpouching or sac-like dilatation in the wall of the vertebral artery .
http://purl.obolibrary.org/obo/HP_0034180	Fusion of the caudate and putamen	http://purl.obolibrary.org/obo/HP_0002339	Abnormal caudate nucleus morphology		Abnormal joined appearance of the caudate and putamen with an absence of the anterior limb of the internal capsule.
http://purl.obolibrary.org/obo/HP_0034181	Aplasia/Hypoplasia of the liver	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Absence or underdevelopment of the liver.
http://purl.obolibrary.org/obo/HP_0034182	Segmental hypoplasia of liver	http://purl.obolibrary.org/obo/HP_0034181	Aplasia/Hypoplasia of the liver		Anatomically the liver is divided into right and left lobes based on the attachment of its peritoneal ligaments. This term refers to a developmental anomaly characterzied by the underdevelopment of one of the lobes of the liver. This is a rare and usually asymptomatic anomaly that can be detected incidentally on cross sectional imaging with computed tomography or magnetic resonance imaging.
http://purl.obolibrary.org/obo/HP_0034183	Spastic triplegia	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Spastic weakness found in both lower extremities and one upper extremity.
http://purl.obolibrary.org/obo/HP_0034184	Elevated circulating insulin-like growth factor-binding protein acid labile subunit concentration	http://purl.obolibrary.org/obo/HP_0031034	Abnormal circulating insulin-like growth factor-binding protein acid labile subunit concentration		The concentration of insulin-like growth factor-binding protein acid labile subunit in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034185	Median pseudocleft lip	http://purl.obolibrary.org/obo/HP_0000161	Median cleft upper lip		A type of mild median cleft lip in which the central tubercle of the upper lip is replaced by a mucosal cleft in the midline.
http://purl.obolibrary.org/obo/HP_0034186	Patella alta	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		Patella alta is a patella that rides abnormally high in relation to the femur, the femoral trochlea, or the tibia, with decreased bony stability requiring increased knee flexion angles to engage the trochlea.
http://purl.obolibrary.org/obo/HP_0034187	Clavicular pseudarthrosis	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		A developmental defect in a the clavicule leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or false joint).
http://purl.obolibrary.org/obo/HP_0034188	Midline liver	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Position of the liver across the middle of the body instead of being in its normal position to the right of the stomach.
http://purl.obolibrary.org/obo/HP_0034189	Anti-thyroid-stimulating hormone receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0430050	Anti-thyroid antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid-stimulating hormone.
http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		Abnormal functionality of the fetal cardiovascular system.
http://purl.obolibrary.org/obo/HP_0034191	Elevated fetal middle cerebral artery peak systolic velocity	http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology		Increased peak systolic velocity of the fetal middle cerebral artery (MCA) as evaluated by Doppler ultrasound.
http://purl.obolibrary.org/obo/HP_0034192	Pulmonary thromboembolism	http://purl.obolibrary.org/obo/HP_0001907	Thromboembolism		Pulmonary embolism is caused by emboli, which have originated from venous thrombi, traveling to and occluding the arteries of the lung.
http://purl.obolibrary.org/obo/HP_0034193	Stratum basale cleavage	http://purl.obolibrary.org/obo/HP_0033802	Intra-epidermal blistering		Cleavage within the epidermal keratinocytes, which is the innermost layer of the epidermis and consists of proliferating cells that give rise to the outer layers of the epidermis.
http://purl.obolibrary.org/obo/HP_0034194	Suprabasal cleavage	http://purl.obolibrary.org/obo/HP_0033802	Intra-epidermal blistering		Cleavage within the suprabasal cell layer of the epidermis, which lies directly above the basal layer and is composed of five to ten layers of cells.
http://purl.obolibrary.org/obo/HP_0034195	Triggered by muscle relaxant	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to a muscle relaxant such as suxamethonium and mivacurium.
http://purl.obolibrary.org/obo/HP_0034196	Ductus venosus agenesis	http://purl.obolibrary.org/obo/HP_0010948	Abnormal fetal cardiovascular morphology		A developmental defect characterized by lack of formation of the ductus venosus (a shunt that allows oxygenated blood in the umbilical vein to bypass the liver in the fetal circulation).
http://purl.obolibrary.org/obo/HP_0034197	Third trimester onset	http://purl.obolibrary.org/obo/HP_0011461	Fetal onset		This term refers to a phenotypic feature that was first observed prior to birth during the third trimester, which is defined as 28 weeks and zero days (28+0) of gestation and beyond.
http://purl.obolibrary.org/obo/HP_0034198	Second trimester onset	http://purl.obolibrary.org/obo/HP_0011461	Fetal onset		This term refers to a phenotypic feature that was first observed prior to birth during the second trimester, which comprises the range of gestational ages from 14 0/7 weeks to 27 6/7 (inclusive).
http://purl.obolibrary.org/obo/HP_0034199	Late first trimester onset	http://purl.obolibrary.org/obo/HP_0011461	Fetal onset		This term refers to a phenotypic feature that was first observed prior to birth in the first trimester during the early fetal period, which is defined as 11 0/7 to 13 6/7 weeks of gestation (inclusive).
http://purl.obolibrary.org/obo/HP_0034201	Increased CSF homovanillic acid concentration	http://purl.obolibrary.org/obo/HP_0034200	Abnormal CSF homovanillic acid concentration		Elevated concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine.
http://purl.obolibrary.org/obo/HP_0034203	Decreased iduronate sulfatase level	http://purl.obolibrary.org/obo/HP_0034202	Abnormal iduronate sulfatase concentration		An decreased level of iduronate-2-sulfatase activity in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034204	Decreased circulating C1-esterase inhibitor concentration	http://purl.obolibrary.org/obo/HP_0005339	Abnormality of complement system		Decreased concentration of C1-esterase inhibitor (C1INH) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034205	Iniencephaly	http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect		Iniencephaly is a rare neural tube defect involving dysmorphic spine and abnormal fusion of the portion of the occipital skull with the back. It results in extreme fixed head retroflexion.
http://purl.obolibrary.org/obo/HP_0034206	Abnormal fetal central nervous system morphology	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		An anomalous structural finding of the fetal central nervous system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0034208	Fetal intracranial hemorrhage	http://purl.obolibrary.org/obo/HP_0034206	Abnormal fetal central nervous system morphology		Abnormal bleeding inside the skull (cranium) of a fetus.
http://purl.obolibrary.org/obo/HP_0034209	Fetal subependymal hemorrhage	http://purl.obolibrary.org/obo/HP_0034210	Fetal intraventricular hemorrhage		A type of fetal intracranial hemorrhage located in the subependymal germinal matrix below the frontal horns of the lateral ventricles in the caudothalamic notch.
http://purl.obolibrary.org/obo/HP_0034210	Fetal intraventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0034208	Fetal intracranial hemorrhage		A type of fetal intracranial hemorrhage with bleeding into the ventricular system of the brain.
http://purl.obolibrary.org/obo/HP_0034211	Fetal cerebral parenchymal hemorrhage	http://purl.obolibrary.org/obo/HP_0034208	Fetal intracranial hemorrhage		A type of fetal intracranial hemorrhage with bleeding into the parenchyma (tissue) of the brain.
http://purl.obolibrary.org/obo/HP_0034212	Fetal extra-axial hemorrhage	http://purl.obolibrary.org/obo/HP_0034208	Fetal intracranial hemorrhage		A type of fetal intracranial hemorrhage with bleeding that occurs within the skull but outside of the brain tissue itself (into the epidural, subdural, or arachnoid space).
http://purl.obolibrary.org/obo/HP_0034213	Fetal posterior fossa hemorrhage	http://purl.obolibrary.org/obo/HP_0034208	Fetal intracranial hemorrhage		A type of fetal intracranial hemorrhage that occurs in the posterior cranial fossa, which is the part of the cranial cavity that is located between the foramen magnum and tentorium cerebelli and contains the brainstem and cerebellum.
http://purl.obolibrary.org/obo/HP_0034214	Fetal intraventricular hemorrhage without ventriculomegaly	http://purl.obolibrary.org/obo/HP_0034210	Fetal intraventricular hemorrhage		A type of fetal intraventricular hemorrhage characterized by clear hemorrhage spillover to the ventricles filling less than 50% of the lateral ventricle and without ventriculomegaly of greater than 15 mm in the transverse diameter of the lateral ventricular atrium.
http://purl.obolibrary.org/obo/HP_0034215	Fetal cerebellar hemisphere hemorrhage	http://purl.obolibrary.org/obo/HP_0034213	Fetal posterior fossa hemorrhage		A type of fetal intracranial hemorrhage that occurs in the hemisphere of the cerebellum.
http://purl.obolibrary.org/obo/HP_0034216	Fetal cerebellar vermis hemorrhage	http://purl.obolibrary.org/obo/HP_0034213	Fetal posterior fossa hemorrhage		A type of fetal intracranial hemorrhage that occurs in the vermis of the cerebellum.
http://purl.obolibrary.org/obo/HP_0034217	Sonographic non-visualized fetal bladder	http://purl.obolibrary.org/obo/HP_0034242	Abnormal fetal genitourinary system morphology		Inability to visualize the fetal bladder on targeted prenatal sonography examination. The fetal bladder can be visualized with sonography as a midline, fluid-filled structure in the pelvis as early as 10-12 weeks of gestation. The normal fetus voids at least once an hour but never completely empties the urinary bladder. The fetal bladdder should be consistently imaged after 13 weeks of gestation.
http://purl.obolibrary.org/obo/HP_0034218	Fetal intraventricular hemorrhage with ventriculomegaly	http://purl.obolibrary.org/obo/HP_0034210	Fetal intraventricular hemorrhage		A type of fetal intraventricular hemorrhage (IVH) characterized by spillover to ventricles with flooding of 50% or more of one or both lateral ventricles accrued accompanying ventriculomegaly, but with no apparent brain parenchymal injury. This type of IVH may be defined as a diameter exceeding 15 mm in the transverse diameter of the lateral ventricular atrium as visualiuzed by prenatal sonography.
http://purl.obolibrary.org/obo/HP_0034219	Fetal intraventricular hemorrhage with periventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0034210	Fetal intraventricular hemorrhage		A type of fetal intraventricular hemorrhage that additionally includes hemorrhage in a large part of the periventricular parenchyma.
http://purl.obolibrary.org/obo/HP_0034220	Temporal lobe megalencephaly	http://purl.obolibrary.org/obo/HP_0034221	Abnormal temporal lobe morphology		Expansion of the temporal lobes of the brain along all axes, including rostrocaudal, superoinferior, and mediolateral, resulting in a globular appearance of the brain.
http://purl.obolibrary.org/obo/HP_0034221	Abnormal temporal lobe morphology	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		An abnormal structural of the zone (lobe) of the cerebral cortex that is located inferior to the lateral fissure on other cerebral hemispheres.
http://purl.obolibrary.org/obo/HP_0034222	Temporal lobe dysplasia	http://purl.obolibrary.org/obo/HP_0034221	Abnormal temporal lobe morphology		A developmental defect of the temporal lobe of the cerebral cortex that is characterized by prominent sulcations and radially directed gyrations.
http://purl.obolibrary.org/obo/HP_0034223	Elevated umbilical artery pulsatility	http://purl.obolibrary.org/obo/HP_0025715	Abnormal umbilical artery doppler waveform during pregnancy		Human umbilical artery (UA) blood flow pulsatility measured by Doppler ultrasound is a widely used biomarker for the detection of elevated placental vascular resistance. Elevated UA pulsatility, which in the most extreme cases manifests as absent or even reversed end-diastolic velocity, is associated with intrauterine growth restriction (IUGR) and still-birth.
http://purl.obolibrary.org/obo/HP_0034224	Absent end-diastolic umbilical artery flow	http://purl.obolibrary.org/obo/HP_0025715	Abnormal umbilical artery doppler waveform during pregnancy		An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an absence of flow in the umbilical artery at the end of diastole.
http://purl.obolibrary.org/obo/HP_0034225	Reversed end-diastolic umbilical artery flow	http://purl.obolibrary.org/obo/HP_0025715	Abnormal umbilical artery doppler waveform during pregnancy		An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an reversal of flow in the umbilical artery at the end of diastole (i.e., backwards flow).
http://purl.obolibrary.org/obo/HP_0034226	Champagne cork sign	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		Characteristic appearance of the chest and abdomen in the sagittal view on prenatal ultrasound when the chest is small and the abdomen protruding.
http://purl.obolibrary.org/obo/HP_0034227	Aortic isthmus hypoplasia	http://purl.obolibrary.org/obo/HP_0012304	Hypoplastic aortic arch		A type of aortic arch hypoplasia whereby the isthmus (arch between the left subclavian and insertion of the patent ductus arteriosus/ligamentum arteriosum) has a diameter of less than 40% of the diameter of the ascending aorta.
http://purl.obolibrary.org/obo/HP_0034228	Proximal aortic arch hypoplasia	http://purl.obolibrary.org/obo/HP_0012304	Hypoplastic aortic arch		A type of aortic arch hypoplasia whereby the proximal aortic arch (arch proximal to the origin of the left subclavian artery) has a diameter of less than 60% of the diameter of the ascending aorta.
http://purl.obolibrary.org/obo/HP_0034229	Distal aortic arch hypoplasia	http://purl.obolibrary.org/obo/HP_0012304	Hypoplastic aortic arch		A type of aortic arch hypoplasia whereby the distal aortic arch (arch distal to the ductus arteriosus) has a diameter of less than 60% of the diameter of the ascending aorta.
http://purl.obolibrary.org/obo/HP_0034230	Inferior crossed fused renal ectopia	http://purl.obolibrary.org/obo/HP_0004736	Crossed fused renal ectopia		A type of cross fused renal ectopia characterized by fusion between the upper pole of the cross-fused ectopic kidney (located more inferiorly relative to the other kidney) and the lower pole of the other orthotopic kidney (located in a more superior position).
http://purl.obolibrary.org/obo/HP_0034231	Sigmoid kidney	http://purl.obolibrary.org/obo/HP_0004736	Crossed fused renal ectopia		A type of cross fused renal ectopia where the normal side kidney is present superiorly and the direction of pelvic is medial, the kidney which crosses positioned inferiorly with direction of pelvic toward the lateral side. As kidneys fuse after complete rotation on the vertical axis, both renal pelves lie in correct orientation.
http://purl.obolibrary.org/obo/HP_0034232	Unilateral lump kidney	http://purl.obolibrary.org/obo/HP_0004736	Crossed fused renal ectopia		A type of cross fused renal ectopia where fusion occurs over a wide margin, both renal pelves anteriorly directed and placed more inferiorly.
http://purl.obolibrary.org/obo/HP_0034233	Disc kidney	http://purl.obolibrary.org/obo/HP_0004736	Crossed fused renal ectopia		A type of cross fused renal ectopia in which kidneys fuse along their medial borders.
http://purl.obolibrary.org/obo/HP_0034234	L-shaped kidney	http://purl.obolibrary.org/obo/HP_0004736	Crossed fused renal ectopia		A type of cross fused renal ectopia in which the crossed kidney lies inferiorly and transversely, fused with the lower pole of the normal kidney.
http://purl.obolibrary.org/obo/HP_0034235	Superior crossed-fused renal ectopia	http://purl.obolibrary.org/obo/HP_0004736	Crossed fused renal ectopia		A type of cross fused renal ectopia in which the ectopic kidney lies superiorly and its lower pole fuses with the upper pole of the normal kidney. The renal pelvis of both kidneys lies anteriorly.
http://purl.obolibrary.org/obo/HP_0034236	Apnea of prematurity	http://purl.obolibrary.org/obo/HP_0002104	Apnea		Recurrent episodes of apnea occurring in infants born less than 37 weeks of gestation, defined specifically as a pause of breathing for more than 15-20 s, or accompanied by oxygen desaturation (SpO2 not more than 80% for at least 4 s) and bradycardia (heart rate less than 2/3 of baseline for at least 4 s), in infants born less than 37 weeks of gestation.
http://purl.obolibrary.org/obo/HP_0034239	Renal vein thrombosis	http://purl.obolibrary.org/obo/HP_0033835	Abnormal renal vascular morphology		The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output.
http://purl.obolibrary.org/obo/HP_0034240	Fetal neck mass	http://purl.obolibrary.org/obo/HP_0025667	Fetal neck anomaly		An abnormal growth (lump) of tissue in the neck region of a fetus. Masses may be simple cystic,, cystic with a few simple septations (fewer than three septations and less than 3-mm thick), cystic with multiple or thick septations (greater than three septations or septations 3-mm-thick or more), a mass that is than is less than 50% solid, and a mass that is 50% solid or more.
http://purl.obolibrary.org/obo/HP_0034242	Abnormal fetal genitourinary system morphology	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		An anomalous structural finding of the fetal genitourinary system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0034243	Abnormal fetal pulmonary morphology	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		An anomalous structural finding of the fetal lungs. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0034244	Gastric pseudomass	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		At US examination from the second trimester onward, the fetal stomach appears as a uniformly anechoic, sharply circumscribed round structure in the left upper quadrant. However, debris is commonly visualized in the stomach, forming a pseudomass.
http://purl.obolibrary.org/obo/HP_0034246	Fetal scalp mass	http://purl.obolibrary.org/obo/HP_0034245	Fetal head anomaly		An abnormal growth (lump) of tissue that projects from the fetal scalp.
http://purl.obolibrary.org/obo/HP_0034247	Fetal lower urinary tract obstruction	http://purl.obolibrary.org/obo/HP_0034242	Abnormal fetal genitourinary system morphology		An obstruction in the ureter leading to bladder outlet obstruction. Special criteria are used for lower urinary tract obstruction (LUTO) in the fetus. Prenatal LUTO has classically been suspected on the basis of three ultrasonographic findings: megacystis, dilated posterior urethra (known as the keyhole sign) and hydronephrosis.
http://purl.obolibrary.org/obo/HP_0034248	Increased fetal lens echogenicity	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		Increased echogenicity (increased brightness in the gray-scale sonography image) of the lens of a fetus.
http://purl.obolibrary.org/obo/HP_0034249	Severe influenza infection	http://purl.obolibrary.org/obo/HP_5210320	Unusual influenza infection		An unusually severe infection by an influenza virus.
http://purl.obolibrary.org/obo/HP_0034250	Fetal nuchal edema	http://purl.obolibrary.org/obo/HP_0025667	Fetal neck anomaly		Nuchal edema is considered present in a fetus at gestational week 14 or more if in the midsagittal plane of the neck, there is subcutaneous edema that produces a characteristic tremor on ballotment of the fetal head. This constitutes the severe end of the spectrum of increased nuchal fold thickness, which is defined as soft-tissue thickening of 6 mm or more, seen in the suboccipitobregmatic view of the fetal head. Nuchal edema may be confined to the neck or it may be generalized, as part of hydrops fetalis.
http://purl.obolibrary.org/obo/UBERON_7500102	preorbital bone region	http://purl.obolibrary.org/obo/UBERON_0001062	anatomical entity		Part of the orbital plate formed by the jugal (part of the zygomatic), lacrimal (which is sometimes fused), sometimes nasal (typically in species with elongated rostra), and maxilla bones anterior to the orbit.
http://purl.obolibrary.org/obo/UBERON_7500103	preorbital fossa	http://purl.obolibrary.org/obo/UBERON_0004704	bone fossa		A hollow (fossa) in the preorbital region, typically lying on the maxillary bone, although sometimes can touch nasal bones (e.g., modern Equus).
http://purl.obolibrary.org/obo/CL_4030022	renal medullary fibroblast	http://purl.obolibrary.org/obo/CL_1000692	kidney interstitial fibroblast		A fibroblast that is located in the renal medulla interstitium.
http://purl.obolibrary.org/obo/CL_0017002	prostate neuroendocrine cell	http://purl.obolibrary.org/obo/CL_0000165	neuroendocrine cell		A neuroendocrine cell that is part of the prostate epithelium.
http://purl.obolibrary.org/obo/CL_4023161	unipolar brush cell	http://purl.obolibrary.org/obo/CL_0000679	glutamatergic neuron		An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles.
http://purl.obolibrary.org/obo/CL_4030025	renal cortical fibroblast	http://purl.obolibrary.org/obo/CL_1000692	kidney interstitial fibroblast		A fibroblast that is located in the renal cortical interstitium.
http://purl.obolibrary.org/obo/HsapDv_0000266	young adult stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		A prime adult stage that refers to an adult who is under 40 years old.
http://purl.obolibrary.org/obo/CL_4030031	interstitial cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. "Interstitial cell" is a morphological term and refers to a variety of cells with differing origins and phenotypes.
http://purl.obolibrary.org/obo/CL_4030032	valve interstitial cell	http://purl.obolibrary.org/obo/CL_1000147	cardiac valve cell		An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes.
http://purl.obolibrary.org/obo/CL_4030033	valve endothelial cell	http://purl.obolibrary.org/obo/CL_1000147	cardiac valve cell		An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes.
http://purl.obolibrary.org/obo/HP_0034517	Pretibial plaque	http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin		Pretibial plaques occur in a specific pattern with hyperpigmentation, atrophy or induration and scarring of the lower limbs typically over the pretibial area. Hyperpigmentation appears to develop gradually from mild, brownish hyperpigmented patches clinically in keeping with haemosiderin deposition, to indurated or atrophic plaques and can progress to cover the entire circumference of the calf. Plaques are often associated with skin fragility, whether atrophic or indurated. They are thought to be a result of extensive bruising and confluent atrophic scars because of the increased fragility of dermis and small blood vessels.
http://purl.obolibrary.org/obo/HP_0034518	Gingival fragility	http://purl.obolibrary.org/obo/HP_0000168	Abnormality of the gingiva		Gums that are easily damaged.
http://purl.obolibrary.org/obo/HP_0034519	Muscle fiber fuchsinophilic inclusion bodies	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		The presence of inclusion bodies within the cytoplasm of muscle cells that react positively with acid fuchsin.
http://purl.obolibrary.org/obo/HP_0034520	Esophageal myenteric plexus degeneration	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Deterioration of the cells of the myenteric plexus (also known as the Auerbach plexus) located between the layers of the muscular propria of the esophagus.
http://purl.obolibrary.org/obo/HP_4000093	Ectopic tooth eruption	http://purl.obolibrary.org/obo/HP_0006292	Abnormality of dental eruption		A condition in which the permanent teeth, because of deficiency of growth in the jaw or segment of jaw, assume a path of eruption that intercepts a primary tooth, causes its premature loss and produces a consequent malposition of the permanent tooth.
http://purl.obolibrary.org/obo/HP_4000094	Corpus cavernosum hypoplasia	http://purl.obolibrary.org/obo/HP_0100623	Abnormal corpus cavernosum morphology		A developmental anomaly characterized by undergrowth of the corpus cavernosum.
http://purl.obolibrary.org/obo/HP_4000095	Elevated circulating thymine concentration	http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration		Concentration of the nucleobase thymine in the blood circulation above the normal range.
http://purl.obolibrary.org/obo/HP_4000100	Positive lactose hydrogen breath test	http://purl.obolibrary.org/obo/HP_6000259	Positive hydrogen breath test		Elevated hydrogen gas level in exhaled breath following oral administration of lactose. In individuals with lactose intolerance, undigested lactose in the colon will be metabolized by colonic bacteria, releasing hydrogen gas.
http://purl.obolibrary.org/obo/HP_4000102	Triggered by allopurinol	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to allopurinol.
http://purl.obolibrary.org/obo/HP_4000103	Ameliorated by oral zinc supplementation	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by oral zinc supplementation.
http://purl.obolibrary.org/obo/HP_4000104	Curved dental root	http://purl.obolibrary.org/obo/HP_0006486	Abnormal dental root morphology		A root of a tooth that is more rounded than normal.
http://purl.obolibrary.org/obo/HP_4000105	Abnormal four chamber view of the fetal heart	http://purl.obolibrary.org/obo/HP_0010948	Abnormal fetal cardiovascular morphology		The four-chamber (4Ch) view of the fetal heart is the most widely used screening examination for the detection of structural cardiac abnormalities during routine fetal ultrasonography. In the healthy normal fetus, the apical 4Ch view demonstrates four well-developed chambers, a concordant atrioventricular (AV) connection, unobstructed AV valves (mitral and tricuspid valves), the foramen ovale flap opening into left atrium (LA), and an intact interventricular septum. Additionally, the pulmonary venous opening can be visualized at the LA wall. Any structural deviations from normal anatomy may lead to congenital heart disease that can be determined by the 4Ch view of the fetal heart's ultrasound imaging.
http://purl.obolibrary.org/obo/HP_4000106	Spleen hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A hamartomatous lesion (benign focal lesions composed of disorganized tissue elements) localized in the spleen.
http://purl.obolibrary.org/obo/HP_4000107	Positive lupus band test	http://purl.obolibrary.org/obo/HP_0031538	Abnormal dermoepidermal junction morphology		Deposits of immunoglobulins and complement components along the dermoepidermal junction.
http://purl.obolibrary.org/obo/HP_4000108	Bone marrow erythroid vacuolization	http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology		Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of erythroid precursors in the bone marrow.
http://purl.obolibrary.org/obo/HP_4000109	Triggered by electromagnetic field	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure to an electromagnetic field.
http://purl.obolibrary.org/obo/HP_4000110	Exposure history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Information about current and past exposure to metals, dust, fibers, fumes, chemicals, biologic hazards, radiation, noise, and/or vibration at work or home.
http://purl.obolibrary.org/obo/HP_4000111	Asbestos exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of exposure to asbestos, a fibrous mineral with physical and chemical properties that make it resistant to heat and degradation.
http://purl.obolibrary.org/obo/HP_4000112	Medication history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Information about current or past medications taken by an individual.
http://purl.obolibrary.org/obo/HP_4000113	Aminoglycoside exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken aminoglycoside antibiotics.
http://purl.obolibrary.org/obo/HP_4000114	Statin exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken statins, also known as HMG-CoA reductase inhibitors.
http://purl.obolibrary.org/obo/HP_4000115	Potassium-sparing diuretic exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken a potassium-sparing diuretic exposure such as amiloride, eplerenone, spironolactone, and triamterene.
http://purl.obolibrary.org/obo/HP_4000116	Carbamazepine exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken carbamazepine.
http://purl.obolibrary.org/obo/HP_4000117	Valproate exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken valproate (valproic acid).
http://purl.obolibrary.org/obo/HP_4000118	Hydralazine exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken hydralazine.
http://purl.obolibrary.org/obo/HP_4000119	Calcium channel blocker exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having taken a calcium channel blocker such as amlodipine, nicardipine, nifedipine, verapamil, or diltiazem.
http://purl.obolibrary.org/obo/HP_4000121	Triggered by poison ivy, poson oak, or sumac	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure (cutaneous contact) to poison ivy, poison oak, and poison sumac. These three plants each contain urushiol. Contact with these plants is the most common causes of clinically diagnosed allergic contact dermatitis.
http://purl.obolibrary.org/obo/HP_4000122	History of exclusive breast feeding	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A past medical history of having been fed exclusively by breast feeding.
http://purl.obolibrary.org/obo/HP_4000123	Nutrition history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A part of the past medical history consisting of information about the typical food intake of an individual.
http://purl.obolibrary.org/obo/HP_4000124	High dietary oxalate intake	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A history of ingestion of a relatively high amount of foods containing high levels of oxalate, such as green-leaf vegetables, tea, nuts, chocolate and rhubarb.
http://purl.obolibrary.org/obo/HP_4000125	Recent honey ingestion	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A history of ingestion of honey in recent weeks.
http://purl.obolibrary.org/obo/HP_4000126	Raw egg-white ingestion	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A history of eating raw egg whites.
http://purl.obolibrary.org/obo/HP_4000127	Exacerbated by sodium channel blocking agent exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by administration of sodium channel blocking agents such as phenytoin, carbamazepine, oxcarbazepine, lamotrigine, topiramate, and zonisamide.
http://purl.obolibrary.org/obo/HP_4000128	Addictive nitrous oxide use	http://purl.obolibrary.org/obo/HP_0033511	Addictive substance use		Addiction to inhaled nitrous oxide gas (N2O) is a growing concern.
http://purl.obolibrary.org/obo/HP_4000129	Recent blood transfusion	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A past medical history of a recent blood transfusion.
http://purl.obolibrary.org/obo/HP_4000130	Ameliorated by colchicine	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by administration of colchizine.
http://purl.obolibrary.org/obo/HP_4000131	Ameliorated by vitamin D	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by administration of vitamin D.
http://purl.obolibrary.org/obo/HP_4000132	Exacerbated by phenytoin exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by administration of phenytoin.
http://purl.obolibrary.org/obo/HP_4000133	Triggered by angiotensin-converting enzyme inhibitor	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to anngiotensin-converting enzyme inhibitor such as benazepril, captopril, enalapril, fosinopril, and lisinopril.
http://purl.obolibrary.org/obo/HP_4000134	Prostaglandin E1 exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treateed with prostaglandin E1.
http://purl.obolibrary.org/obo/HP_4000135	5-fluorouracil exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with 5-fluorouracil.
http://purl.obolibrary.org/obo/HP_4000136	6-mercaptopurine exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treateed with 6-mercaptopurine.
http://purl.obolibrary.org/obo/HP_4000137	Isoniazid exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treateed with isoniazid.
http://purl.obolibrary.org/obo/HP_4000138	Absent cavum septum pellucidum	http://purl.obolibrary.org/obo/HP_0034206	Abnormal fetal central nervous system morphology		The cavum septum pellucidum (CSP) is an important fetal midline forebrain landmark that is normally visible by prenatal sonography. This term refers to the lack of visibility of the CSP on prenatal sonography. The CSP normally can be visualized between 18 and 37 weeks of gestation. Lack of visualization of the CSP in this time period generally requires follow up and may indicate the presence of underlying malformations such as malformations of the corpus callosum. The lack of CSP before 18 weeks or after 37 weeks of gestation (or postnatally) is considered a normal finding.
http://purl.obolibrary.org/obo/HP_4000139	Fetal abdominal cyst	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Fetal abdominal cysts are usually detected during the second trimester anomaly scan or discovered incidentally at later gestations. However, a definitive diagnosis is often not made until postnatal life. The most common etiologies of fetal abdominal cysts are: ovarian, gastrointestinal cystic duplication, liver and choledochal, meconium pseudocysts, mesenteric and adrenal. Following identification of a cyst, careful morphological assessment allows the prediction of their natural history and importantly, the likelihood of surgical intervention being required postnatally.
http://purl.obolibrary.org/obo/HP_4000140	Fetal bowel dilatation	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Fetal bowel dilatation is characterized by fluid-filled intestinal loops which measure at least fifteen millimeters long or seven millimeters in diameter. Ultrasonographic image of dilated fetal bowel is a sign of intestinal mechanical or functional obstruction and its prevalence will depend on the underlying condition: bowel atresia or stenosis, malrotation with volvulus, meconium ileus, total colonic aganglionosis, and meconium plug syndrome. The etiology of fetal bowel dilatation is a difficult prenatal diagnosis since ultrasound has limited accuracy for bowel evaluation.
http://purl.obolibrary.org/obo/HP_4000141	Left ventricular dilatation	http://purl.obolibrary.org/obo/HP_0001711	Abnormal left ventricle morphology		Enlargement of the chamber of the left heart ventricle.
http://purl.obolibrary.org/obo/HP_4000142	Fetal trigonocephaly	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		A fetal ultrasound finding defined by flattening of the occiput with pointing of the frontal bones and brachycephaly with an increased cephalic index. It is characterized by keel shaped deformity of forehead with midline ridge, bilateral fronto temporal constriction with compensatory biparietal expansion, supra orbital and lateral orbital retrusion and hypotelorism. This finding is said to resemble a strawberry.
http://purl.obolibrary.org/obo/HP_4000143	Abnormal fetal heart outflow tract	http://purl.obolibrary.org/obo/HP_0010948	Abnormal fetal cardiovascular morphology		A prenatal anomaly of the outflow tract. Fetal ultrasound may not always be able to easily and accurately describe the outflow anomaly, but can detect abnormal anatomy. Often, follow up with a fetal echo is recommended, but fetal ultrasound is limited.
http://purl.obolibrary.org/obo/HP_4000145	History of recent viral illness	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of a viral illness in recent weeks.
http://purl.obolibrary.org/obo/HP_4000146	History of recent dental procedure	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of a dental procedure in recent weeks.
http://purl.obolibrary.org/obo/HP_4000147	Abnormal hepatic artery morphology	http://purl.obolibrary.org/obo/HP_0006707	Abnormality of the hepatic vasculature		Any structural anomaly of the hepatic artery or its branches.
http://purl.obolibrary.org/obo/HP_4000148	Hepatic artery hyperplasia	http://purl.obolibrary.org/obo/HP_4000147	Abnormal hepatic artery morphology		Abnormal increase in size of the hepatic arteries.
http://purl.obolibrary.org/obo/HP_4000149	Lymph node necrosis	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		Areas of necrotic tissue within a lymph node.
http://purl.obolibrary.org/obo/HP_4000150	Multinucleated neuron	http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology		Neurons that contain more than one nucleus.
http://purl.obolibrary.org/obo/HP_4000151	History of recent contralateral injury	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A history of an injury that occurred several hours, days, or weeks before the current presenting complaint and is located on the other side of the body relative to the current presenting complaint.
http://purl.obolibrary.org/obo/HP_4000152	Alternating laterality	http://purl.obolibrary.org/obo/HP_0012831	Laterality		Occurring on the left and right in succession. This term can refer to alternating sides of the body (e.g., Alternating hemiplegia) or alternative sides of the visual field (e.g., some migraine auras).
http://purl.obolibrary.org/obo/HP_4000153	Cervical squamous cell papilloma	http://purl.obolibrary.org/obo/HP_0032241	Cervical neoplasm		A benign tumor arising from the epithelial surface of the cervix and usually caused by Human Papillomavirus infection.
http://purl.obolibrary.org/obo/HP_4000154	Liver leiomyoma	http://purl.obolibrary.org/obo/HP_0002896	Neoplasm of the liver		A benign smooth muscle neoplasm that arises in the liver.
http://purl.obolibrary.org/obo/HP_4000158	Typified by high penetrance	http://purl.obolibrary.org/obo/HP_0003829	Typified by incomplete penetrance		Description of conditions in which only an incomplete but relatively high proportion of individuals with a given genotype exhibit the disease regardless of age assuming a full lifespan of 80 years. There is no commonly accepted definition for incomplete, but high penetrance, but we suggest that this term be applied if at least 80 percent but less than 100 percent of individuals with the given genotype would manifest the disease with a full lifespan.
http://purl.obolibrary.org/obo/HP_4000159	Typified by moderate penetrance	http://purl.obolibrary.org/obo/HP_0003829	Typified by incomplete penetrance		Description of conditions in which only a moderate proportion of individuals with a given genotype exhibit the disease regardless of age assuming a full lifespan of 80 years. There is no commonly accepted definition for moderate penetrance, but we suggest that this term be applied if at least 20 percent but less than 80 percent of individuals with the given genotype would manifest the disease with a full lifespan.
http://purl.obolibrary.org/obo/HP_4000160	Typified by low penetrance	http://purl.obolibrary.org/obo/HP_0003829	Typified by incomplete penetrance		Description of conditions in which only a low proportion of individuals with a given genotype exhibit the disease regardless of age assuming a full lifespan of 80 years. There is no commonly accepted definition for low penetrance, but we suggest that this term be applied if at least some but less than 20 percent of carriers would manifest the disease with a full lifespan.
http://purl.obolibrary.org/obo/UBERON_8490001	right upper second secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018576	upper second secondary molar tooth		A upper second secondary molar tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490002	right upper first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018575	upper first secondary molar tooth		A upper first secondary molar tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490005	right upper secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018561	upper secondary canine tooth		A upper secondary canine tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490006	right upper lateral secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016455	upper lateral secondary incisor tooth		A upper lateral secondary incisor tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490007	right upper central secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016454	upper central secondary incisor tooth		A upper central secondary incisor tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490009	right lower second secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018579	lower second secondary molar tooth		A lower second secondary molar tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490010	right lower first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018578	lower first secondary molar tooth		A lower first secondary molar tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490013	right lower secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018562	lower secondary canine tooth		A lower secondary canine tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490014	right lower lateral secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018570	lower lateral secondary incisor tooth		A lower lateral secondary incisor tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490015	right lower central secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018568	lower central secondary incisor tooth		A lower central secondary incisor tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490016	right upper second primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018599	upper second primary molar tooth		A upper second primary molar tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490017	right upper first primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018588	upper first primary molar tooth		A upper first primary molar tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490018	right upper primary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018597	upper primary canine tooth		A upper primary canine tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490019	right upper lateral primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018594	upper lateral primary incisor tooth		A upper lateral primary incisor tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490020	right upper central primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018593	upper central primary incisor tooth		A upper central primary incisor tooth that is in the right side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490021	right lower second primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018600	lower second primary molar tooth		A lower second primary molar tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490022	right lower first primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018589	lower first primary molar tooth		A lower first primary molar tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490023	right lower primary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018598	lower primary canine tooth		A lower primary canine tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490024	right lower lateral primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018596	lower lateral primary incisor tooth		A lower lateral primary incisor tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490025	right lower central primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018595	lower central primary incisor tooth		A lower central primary incisor tooth that is in the right side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490027	left upper second secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018576	upper second secondary molar tooth		A upper second secondary molar tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490028	left upper first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018575	upper first secondary molar tooth		A upper first secondary molar tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490031	left upper secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018561	upper secondary canine tooth		A upper secondary canine tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490032	left upper lateral secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016455	upper lateral secondary incisor tooth		A upper lateral secondary incisor tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490033	left upper central secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016454	upper central secondary incisor tooth		A upper central secondary incisor tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490035	left lower second secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018579	lower second secondary molar tooth		A lower second secondary molar tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490036	left lower first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018578	lower first secondary molar tooth		A lower first secondary molar tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490039	left lower secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018562	lower secondary canine tooth		A lower secondary canine tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490040	left lower lateral secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018570	lower lateral secondary incisor tooth		A lower lateral secondary incisor tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490041	left lower central secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018568	lower central secondary incisor tooth		A lower central secondary incisor tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490042	left upper second primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018599	upper second primary molar tooth		A upper second primary molar tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490043	left upper first primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018588	upper first primary molar tooth		A upper first primary molar tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490044	left upper primary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018597	upper primary canine tooth		A upper primary canine tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490045	left upper lateral primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018594	upper lateral primary incisor tooth		A upper lateral primary incisor tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490046	left upper central primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018593	upper central primary incisor tooth		A upper central primary incisor tooth that is in the left side of the upper jaw region.
http://purl.obolibrary.org/obo/UBERON_8490047	left lower second primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018600	lower second primary molar tooth		A lower second primary molar tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490048	left lower first primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018589	lower first primary molar tooth		A lower first primary molar tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490049	left lower primary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018598	lower primary canine tooth		A lower primary canine tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490050	left lower lateral primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018596	lower lateral primary incisor tooth		A lower lateral primary incisor tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_8490051	left lower central primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018595	lower central primary incisor tooth		A lower central primary incisor tooth that is in the left side of the lower jaw region.
http://purl.obolibrary.org/obo/CL_4033020	mucus secreting cell of trachea gland	http://purl.obolibrary.org/obo/CL_4033037	mucus secreting cell of tracheobronchial tree submucosal gland		A mucus secreting cell that is part of a submucosal gland of the trachea.
http://purl.obolibrary.org/obo/CL_4033022	mucus secreting cell of bronchus submucosal gland	http://purl.obolibrary.org/obo/CL_4033037	mucus secreting cell of tracheobronchial tree submucosal gland		A mucus secreting cell of a submucosal gland of the bronchus.
http://purl.obolibrary.org/obo/HP_0034693	Reduced hepatic methionine adenosyltransferase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of methionine adenosyltransferase in the liver below the lower limit of normal. Note that there are multiple methionine adenosyltransferase isoezymes.
http://purl.obolibrary.org/obo/HP_0034694	Substantia nigra dopaminergic neuron loss	http://purl.obolibrary.org/obo/HP_0045007	Abnormal substantia nigra morphology		Degeneration and loss of neurons in the substantia nigra of the brain.
http://purl.obolibrary.org/obo/HP_0034696	Intramuscular lipoma	http://purl.obolibrary.org/obo/HP_0012032	Lipoma		A lipoma that is located within a muscle.
http://purl.obolibrary.org/obo/HP_0034697	Cutaneous telangiectasia	http://purl.obolibrary.org/obo/HP_0001009	Telangiectasia		Dilated blood vessels on the skin.
http://purl.obolibrary.org/obo/HP_0034698	Abnormal aromatase activity	http://purl.obolibrary.org/obo/HP_0034684	Abnormal enzyme concentration or activity		Aromatase activity outside of the normal range.
http://purl.obolibrary.org/obo/HP_0034699	Elevated aromatase activity	http://purl.obolibrary.org/obo/HP_0034698	Abnormal aromatase activity		Enzyme activity of aromatase above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034700	Reduced aromatase activity	http://purl.obolibrary.org/obo/HP_0034698	Abnormal aromatase activity		Enzyme activity of aromatase below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034701	Corneal amyloidosis	http://purl.obolibrary.org/obo/HP_0020015	Amyloid deposition by anatomical site		A form of amyloidosis that is located in the cornea.
http://purl.obolibrary.org/obo/HP_0034702	Abnormal keratinocyte morphology	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Any structural anomaly of the keratinocyte. The keratinocyte is the major cell type of the epidermis and is responsible for generating the protective barrier.
http://purl.obolibrary.org/obo/HP_0034703	Keratinocyte vacuolization	http://purl.obolibrary.org/obo/HP_0034702	Abnormal keratinocyte morphology		Increased number of vacuoles (membrane-bound organelles that areempty of cytoplasm, lined with a membrane, and filled with fluid) in keratinocytes.
http://purl.obolibrary.org/obo/HP_0034704	Parotid gland adenocarcinoma	http://purl.obolibrary.org/obo/HP_0012288	Neoplasm of head and neck		An adenocarcinoma that arises from the parotid gland.
http://purl.obolibrary.org/obo/HP_0034705	Pulmonary vasculitis	http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site		Cellular inflammation, vessel destruction, and tissue necrosis of the blood vessels of the lung.
http://purl.obolibrary.org/obo/HP_0034706	Reduced hepatic D-glycerate kinase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of D-glycerate kinase in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034707	Lymph-node hemophagocytosis	http://purl.obolibrary.org/obo/HP_0012156	Hemophagocytosis		Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages in a lymph node.
http://purl.obolibrary.org/obo/HP_0034708	Superior pubic ramus hypoplasia	http://purl.obolibrary.org/obo/HP_0008830	Hypoplastic pubic ramus		Underdevelopment of the upper branch of the pubis bone (inferior pubic ramus).
http://purl.obolibrary.org/obo/HP_0034709	Uterine adenofibroma	http://purl.obolibrary.org/obo/HP_0010784	Uterine neoplasm		A rare benign mullerian mixed tumor of the uterus composed of benign epithelial and mesenchymal components.
http://purl.obolibrary.org/obo/HP_0034710	Pulmonary hamartoma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		A benign malformation of the lung that includes an abnormal mixture of tissue components such as cartilage, epithelium, fat, or muscle which are common to the lung but without preservation of the organ architecture.
http://purl.obolibrary.org/obo/HP_0034711	Peripheral axonal distension	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		An abnormal histological finding characterized by an increase in the cross-section area of peripheral nerve axons (up to 20-25 micrometers in diameter).
http://purl.obolibrary.org/obo/HP_0034712	Decreased circulating alpha-mannosidase activity	http://purl.obolibrary.org/obo/HP_4000201	Abnormal circulating alpha mannosidase activity		Concentration or activity of alpha mannosidase below the lower limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034713	Abnormal hepatocyte morphology	http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology		A structural anomaly of the hepatocyte, which is the main cell type that makes up the liver perncyhma. Hepatocytes are usually binucleated and appear as sheets in the liver tissue.
http://purl.obolibrary.org/obo/HP_0034714	Hepatic melanin-like lysosomal pigmentation	http://purl.obolibrary.org/obo/HP_0034713	Abnormal hepatocyte morphology		Accumulation of dark, coarsely granular pigment localized in lysosomes of centrilobular hepatocytes.
http://purl.obolibrary.org/obo/HP_0034715	Reduced uroporphyrinogen decarboxylase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme uroporphyrinogen decarboxylase (UROD; EC 4.1.1.37) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034716	Reduced heme oxygenase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme heme oxygenase below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034717	Swollen achromatic neurons in the cerebral cortex	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		The presence of enlarged and swollen neurons that lack Nissl bodies (the rough endoplasmic reticulum-achromasia refers to neurons that lack Nissl bodies) in the cortex of the brain.
http://purl.obolibrary.org/obo/HP_0034718	Vacuolated hepatocytes	http://purl.obolibrary.org/obo/HP_0034713	Abnormal hepatocyte morphology		Presence of vacuoles (membrane-bound organelles that areempty of cytoplasm, lined with a membrane, and filled with fluid) in hepatocytes, which normally rarely contain vacuoles.
http://purl.obolibrary.org/obo/HP_0034719	Lack of oocyte pronucleus formation	http://purl.obolibrary.org/obo/HP_0033338	Abnormal female meiosis		An abnormality of oocyte maturation characterized by the inability of oocytes to form pronuclei after in vitro fertilization procedures. Oocytes normally show two pronuclei 17 to 20 hours after in vitro insemination.
http://purl.obolibrary.org/obo/HP_0034720	Self-healing squamous epithelioma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		A type of skin tumor that initially presents as a reddish macule and subsequently becomes papular, enlarged, ulcerated and ultimately heals leaving pitted scars.
http://purl.obolibrary.org/obo/HP_0034721	Elevated circulating pristanic acid concentration	http://purl.obolibrary.org/obo/HP_0010964	Abnormal circulating long-chain fatty-acid concentration		Concentration of pristanic acid in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034722	Sarcoplasmic bodies	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		Rounded or oval structures that appeared brown on hematoxylin and eosin and red on the modified Gomori trichrome stain.
http://purl.obolibrary.org/obo/HP_0034724	Reduced CSF cystine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Concentration of cystine in the cerebrospinal fluid below the lower limit of normal. Cystine is sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond.
http://purl.obolibrary.org/obo/HP_0034725	Abnormal circulating beta-mannosidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme beta-mannosidase outside normal limits. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides.
http://purl.obolibrary.org/obo/HP_0034726	Elevated circulating beta-mannosidase activity	http://purl.obolibrary.org/obo/HP_0034725	Abnormal circulating beta-mannosidase activity		Activity of the enzyme beta-mannosidase above the upper limit of normal. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides.
http://purl.obolibrary.org/obo/HP_0034727	Reduced circulating alpha-L-fucosidase activity	http://purl.obolibrary.org/obo/HP_0034728	Abnormal circulating alpha-L-fucosidase activity		Activity of the enzyme alpha-L-fucosidase below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034728	Abnormal circulating alpha-L-fucosidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme alpha-L-fucosidase in the blood circulation outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0034729	Elevated circulating alpha-L-fucosidase activity	http://purl.obolibrary.org/obo/HP_0034728	Abnormal circulating alpha-L-fucosidase activity		Activity of the enzyme alpha-L-fucosidase above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034730	Elevated circulating S-adenosyl-L-homocysteine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Increased concentration of S-adenosyl-L-homocysteine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034731	Elevated circulating S-adenosyl-L-methionine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Concentration S-adenosyl-L-methionine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034732	Exercise-triggered malignant hyperthermia	http://purl.obolibrary.org/obo/HP_0002047	Malignant hyperthermia		Malignant hyperthermia that is characterized by exercise-induced life-threatening hyperthermia with a body temperature over 40 degrees C and signs of encephalopathy ranging from confusion to convulsions or coma. Incidence increases with rising ambient temperature and relative humidity. Manifestations may include rhabdomyolysis (presenting with myalgia, muscle weakness, and myoglobinuria), tachycardia, and in severe cases multiorgan failure.
http://purl.obolibrary.org/obo/HP_0034733	Anesthesic-triggered malignant hyperthermia	http://purl.obolibrary.org/obo/HP_0002047	Malignant hyperthermia		Malignant hyperthermia that is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine.
http://purl.obolibrary.org/obo/HP_0034734	Elevated CSF argininosuccinic acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Concentration of argininosuccinic acid in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034735	Elevated CSF aspartylglucosamine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Concentration of aspartylglucosamine in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034736	Elevated circulating alpha-oxoadipic acid concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		Concentration of alpha-oxoadipic acid in the blood above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034737	Abnormal erythrocyte metabolite concentration	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		A deviation from the normal range of a metabolite in red blood cells.
http://purl.obolibrary.org/obo/HP_0034738	Reduced erythrocyte glutathione concentration	http://purl.obolibrary.org/obo/HP_0034737	Abnormal erythrocyte metabolite concentration		Concentration of glutathione in red blood cells below the lower limit of normal. Glutathione (GSH) is an important redox active biomolecule critical in the maintenance and regulation of cellular and organismal health.
http://purl.obolibrary.org/obo/HP_0034739	Elevated CSF sarcosine concentration	http://purl.obolibrary.org/obo/HP_0500225	Abnormal CSF serine family amino acid concentration		Concentration of sarcosine in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034740	Reduced CSF methionine concentration	http://purl.obolibrary.org/obo/HP_0500209	Abnormal CSF methionine concentration		Concentration of methionine in the cerebrospinal fluid below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034741	Elevated circulating homoarginine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Concentration of homoarginine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034742	Elevated urinary formiminoglutamic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of formiminoglutamic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034743	Elevated CSF proline concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Concentration of proline in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034744	Elevated urinary S-sulfocysteine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		Level of S-sulfocysteine high in urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034745	Elevated circulating S-sulfocysteine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Concentration of S-sulfocysteine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034746	Sertoli cell hyperplasia	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Abnormal increase in the number of Sertoli cells in the testis.
http://purl.obolibrary.org/obo/HP_0034747	CSF infectious agent	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		The presence of an infectious agent in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0034748	CSF mycobacteria	http://purl.obolibrary.org/obo/HP_0034429	Bacteria in cerebrospinal fluid		Mycobacterium present in the cerebrospinal fluid (CSF). This feature can be ascertained by CSF microscopy.
http://purl.obolibrary.org/obo/HP_0034749	Fungemia	http://purl.obolibrary.org/obo/HP_0031863	Bloodstream infectious agent		Detection of a fungal organism (such as candida or coccidioides) in the blood stream.
http://purl.obolibrary.org/obo/HP_0034750	Supraclavicular lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Enlarged lymph node located just above the clavicle (collarbone).
http://purl.obolibrary.org/obo/HP_0034751	Inguinal lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Enlarged lymph node located in the inguinal region (groin).
http://purl.obolibrary.org/obo/HP_0034752	Axillary lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Enlarged lymph node located in the axillary region (armpit).
http://purl.obolibrary.org/obo/HP_0034753	Positive Murphy sign	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Murphy's sign is elicited in patients with acute cholecystitis by asking the patient to take in and hold a deep breath while palpating the subcostal region. In practice, Murphy's sign is performed by palpating the subcostal region during inspiration. If pain is elicited and the patient suddenly stops their inspiratory effort, a positive Murphy's sign has been elicited.
http://purl.obolibrary.org/obo/HP_0034754	Bilious emesis	http://purl.obolibrary.org/obo/HP_0002013	Vomiting		Vomiting whereby the vomit has the color of bile, yellowish-green.
http://purl.obolibrary.org/obo/HP_0034755	Ameliorated by NSAID	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with a nonsteroidal anti-inflammatory drug (NSAID).
http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of exposure during pregnancy of the mother of a fetus or child to a medication or other substance.
http://purl.obolibrary.org/obo/HP_0034757	Fetal barbiturate exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to barbiturate medications such as phenobarbital. Barbiturates are used medically as anxiolytics, hypnotics, and anticonvulsants.
http://purl.obolibrary.org/obo/HP_0034758	Fetal narcotic exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy of the mother of a fetus or child to narcotic medications such as morphine or codeine. Narcotics are used medically to treat moderate or severe pain.
http://purl.obolibrary.org/obo/HP_0034759	Ameliorated by ethosuximide	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by administration of ethosuximide. Ethosuximide is most often used to treat absence seizures.
http://purl.obolibrary.org/obo/HP_0034760	Reduced epidermal extracellular matrix protein 1 protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		Lower than normal amount of extracellular matrix protein 1 (ECM1) in the epidermis.
http://purl.obolibrary.org/obo/HP_0034762	Tongue neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized in the tongue.
http://purl.obolibrary.org/obo/HP_0034763	Cardiac neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized in the heart.
http://purl.obolibrary.org/obo/HP_0034764	Gastric neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized in the stomach.
http://purl.obolibrary.org/obo/HP_0034765	Renal neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized in the kidney.
http://purl.obolibrary.org/obo/HP_0034766	Muscle fiber polyglucosan inclusion bodies	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in muscle fibers.
http://purl.obolibrary.org/obo/HP_0034767	Abnormal rete ridge morphology	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Abnormal structure of the rete ridges (also known as rete pegs), which are downward projections of epithelium surrounding the connective tissue papillae in between the dermal papillae.
http://purl.obolibrary.org/obo/HP_0034768	Rete ridge elongation	http://purl.obolibrary.org/obo/HP_0034767	Abnormal rete ridge morphology		Increased length of the rete rdiges of the epidermis.
http://purl.obolibrary.org/obo/HP_0034769	Pulmonary Langerhans cell histiocytosis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Accumulation of monoclonal CD1a-positive Langerhans cells in the bronchioles and alveolar interstitium that can cause damage to the lungs.
http://purl.obolibrary.org/obo/HP_0034770	Lumbar hypolordosis	http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column		Flattening of a curve in the spine in the lumbar (lower back) region.
http://purl.obolibrary.org/obo/HP_0034771	Battle sign	http://purl.obolibrary.org/obo/HP_0031364	Ecchymosis		Battle sign is bruising over the mastoid process that is typically the result of head trauma. It is retroauricular or mastoid ecchymosis that is typically the result of head trauma. Battle sign typically requires significant head trauma and may indicate significant internal injury to the brain and not just the posterior cranial vault or mastoid.
http://purl.obolibrary.org/obo/HP_0034772	Decreased skull base length	http://purl.obolibrary.org/obo/HP_0002693	Abnormal skull base morphology		Reduced anterioposterior dimension of the skull base.
http://purl.obolibrary.org/obo/HP_0034773	Oscillopsia	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		A visual disturbance in which objects in the visual field appear to oscillate (jump, jiggle, vibrate).
http://purl.obolibrary.org/obo/HP_0034774	Decreased blink rate	http://purl.obolibrary.org/obo/HP_0034775	Abnormal blink rate		The frequency with which the eye is blinked is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034775	Abnormal blink rate	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		A deviation from the normal frequency of blinking the eye.
http://purl.obolibrary.org/obo/HP_0034776	Elevated blink rate	http://purl.obolibrary.org/obo/HP_0034775	Abnormal blink rate		The frequecy with which the eye is blinked is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034777	Purulent sputum	http://purl.obolibrary.org/obo/HP_0032016	Abnormal sputum		Sputum contains pus.
http://purl.obolibrary.org/obo/HP_0034778	Maternal hyperthyroidism	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		The mother of a fetus or index patient has a history of hyperthyroidism during the corresponding pregnancy.
http://purl.obolibrary.org/obo/HP_0034779	Perineal	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that affects the perineum (the region of skin between the genitals and the anus).
http://purl.obolibrary.org/obo/HP_0034780	Gadolinium exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of exposure to gadolinium, a contrast medium often used for magnetic resonance imaging.
http://purl.obolibrary.org/obo/HP_0034781	Purulent parotid gland drainage	http://purl.obolibrary.org/obo/HP_0000197	Abnormal parotid gland morphology		Excretion of pus (purulent discharge) from the opening of the parotid duct.
http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site	http://purl.obolibrary.org/obo/HP_0002633	Vasculitis		Vasculitis categorized according to the anatomical site where the finding is localized.
http://purl.obolibrary.org/obo/HP_0034785	Vasculitis by histology	http://purl.obolibrary.org/obo/HP_0002633	Vasculitis		Vasculitis categorized according to type of histological abnormality.
http://purl.obolibrary.org/obo/HP_4000189	Elevated circulating neuron-specific enolase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Concentration of neuron-specific enolase above the upper limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_4000190	Reduced leukocyte alpha-mannosidase activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of an alpha-mannosidase as measured in leukocytes is below the limits of normal.
http://purl.obolibrary.org/obo/HP_4000191	Increased circulating alpha-mannosidase activity	http://purl.obolibrary.org/obo/HP_4000201	Abnormal circulating alpha mannosidase activity		Concentration or activity of alpha mannosidase above the upper limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_4000192	Reduced leukocyte cathepsin D activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of cathepsin D as measured in leukocytes is below the limits of normal. The reduction in cathepsin D activity can also be measured in fibroblasts.
http://purl.obolibrary.org/obo/HP_4000193	Reduced leukocyte N-sulfoglucosamine sulfohydrolase activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of N-sulfoglucosamine sulfohydrolase as measured in leukocytes is below the limits of normal.
http://purl.obolibrary.org/obo/HP_4000194	Pseudohyperkalemia	http://purl.obolibrary.org/obo/HP_0011042	Abnormal circulating potassium concentration		Pseudohyperkalemia describes a falsely elevated potassium level upon measurement of the serum electrolyte concentration due to disruption of cells during the collection or processing of the sample.
http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of an enzyme is above or below the limits of normal in cultured fibroblasts. Fibroblasts are easy to grow in culture and are the main cell type involved in producing extracellular matrix. They are used as a convenient model system for measuring enzyme activity for enzymes that are not expressed in blood cells. Usually, the test is done in fibroblasts for convenience rather than for the investigation of a pathophysiology specific to fibroblasts.
http://purl.obolibrary.org/obo/HP_4000196	Reduced heparan-alpha-glucosaminide N-acetyltransferase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of N-sulfoglucosamine sulfohydrolase as measured in cultured fibroblasts is below the limits of normal.
http://purl.obolibrary.org/obo/HP_4000197	Reduced N-acetylgalactosamine-6-sulfatase in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of N-acetylgalactosamine-6-sulfatase as measured in cultured fibroblasts is below the limits of normal.
http://purl.obolibrary.org/obo/HP_4000198	Reduced acetylglucosamine-6-sulfatase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) as measured in cultured fibroblasts is below the limits of normal. N-acetylglucosamine-6-sulfatase hydrolyzes heparan sulfate and keratan sulfate.
http://purl.obolibrary.org/obo/HP_4000199	Reduced erythrocyte porphobilinogen deaminase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of in the level of porphobilinogen deaminase (EC 4.3.1.8) in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_4000200	Reduced holocarboxylase synthetase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of holocarboxylase synthetase (EC 6.3.4.10) as measured in cultured fibroblasts is below the limits of normal.
http://purl.obolibrary.org/obo/HP_4000202	Reduced tissue alpha-N-acetylgalactosaminidase activity	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of alpha-N-acetylgalactosaminidase (EC 3.2.1.49) is below the limits of normal. The activity can be measured in multiple tissues including cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_4000203	Reduced erythrocyte arginase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of arginase (EC 3.5.3.1) in red blood cells below the lower limit of normal. Arginase catalyzes the last step of the urea cycle.
http://purl.obolibrary.org/obo/HP_4000204	Reduced mitochondrial acetyl-CoA acetyltransferase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of mitochondrial acetyl-CoA acetyltransferase (EC 2.3.1.9) as measured in cultured fibroblasts is below the limits of normal.
http://purl.obolibrary.org/obo/HP_4000205	Reduced tissue beta-mannosidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of beta-mannosidase (EC 3.2.1.25) below the lower limit of normal. Beta-mannosidas enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_4000206	Reduced 3-methylcrotonyl CoA carboxylase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of 3-methylcrotonyl-CoA carboxylase (EC 6.4.1.4) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_4000207	Reduced branched-chain alpha-keto acid dehydrogenase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of branched-chain alpha-keto acid dehydrogenase complex (EC 1.2.4.4) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_4000208	Reduced erythrocyte galactose-1-phosphate uridylyltransferase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of in the level of galactose-1-phosphate uridylyltransferase (GALT; EC 2.7.7.12) in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_4000210	Reduced isovaleryl CoA dehydrogenase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of isovaleryl-CoA dehydrogenase (EC 1.3.99.10) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_4000211	Reduced glycerol kinase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of glycerol kinase (EC 2.7.1.30) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_4000212	Increased circulating vitamin A concentration	http://purl.obolibrary.org/obo/HP_0008372	Abnormal circulating vitamin A concentration		Concentration of vitamin A above the upper limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_4000213	Elevated circulating hyaluronic acid concentration	http://purl.obolibrary.org/obo/HP_0031210	Abnormal circulating hyaluronic acid concentration		Concentration of hyaluronic acid in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_5200200	Olfactory hallucination	http://purl.obolibrary.org/obo/HP_0000738	Hallucinations		Perception of smell without olfactory stimulus.
http://purl.obolibrary.org/obo/HP_5200201	Gustatory hallucination	http://purl.obolibrary.org/obo/HP_0000738	Hallucinations		Perception of taste without gustatory stimulus.
http://purl.obolibrary.org/obo/HP_5200202	Abnormal interpretation of external stimuli	http://purl.obolibrary.org/obo/HP_5200423	Abnormal experience of reality		Abnormal perception of reality is characterized by an abnormal or inaccurate experience of external stimuli.
http://purl.obolibrary.org/obo/HP_5200203	Proprioceptive hallucination	http://purl.obolibrary.org/obo/HP_5200214	Somatic hallucination		A type of hallucination that involves the perception of distorted or abnormal sensations related to one's body position or movement.
http://purl.obolibrary.org/obo/HP_5200205	Illusions	http://purl.obolibrary.org/obo/HP_5200204	Disturbed perception with a stimulus		Perceptual experiences that involve misinterpretations or distortions of sensory stimuli.
http://purl.obolibrary.org/obo/HP_5200207	Inattentiveness illusion	http://purl.obolibrary.org/obo/HP_5200205	Illusions		Instances in which individuals fail to perceive or notice salient or significant stimuli in their visual field due to a lack of attention.
http://purl.obolibrary.org/obo/HP_5200208	Illusions due to affect	http://purl.obolibrary.org/obo/HP_5200205	Illusions		Perceptual distortions or misinterpretations of sensory information arise as a result of the individual's emotional or affective state.
http://purl.obolibrary.org/obo/HP_5200209	Pareidolia	http://purl.obolibrary.org/obo/HP_5200205	Illusions		Apophenia is a psychological phenomenon in which individuals perceive familiar patterns or meaningful images in random or ambiguous stimuli, such as clouds, shadows, or inanimate objects.
http://purl.obolibrary.org/obo/HP_5200210	Autoscopy	http://purl.obolibrary.org/obo/HP_5200216	Abnormal perceptual state		A phenomenon in which an individual perceives themselves from an external perspective, as if they are observing their own body or self from a location outside of their physical body.
http://purl.obolibrary.org/obo/HP_5200211	Subjective eidetic images	http://purl.obolibrary.org/obo/HP_5200423	Abnormal experience of reality		A mental phenomenon is when an individual can vividly visualize or recall visual information from memory with exceptional detail and accuracy. These images are experienced subjectively by the individual, meaning they are not physically present or visible to others.
http://purl.obolibrary.org/obo/HP_5200212	Amplification of social interactions	http://purl.obolibrary.org/obo/HP_5200243	Abnormal change in social behavior		A increase in the tendency of a person to seek or maintain social connections or interactions with others compared to previous norms for an individual.
http://purl.obolibrary.org/obo/HP_5200213	Diminishment of emotional responsiveness	http://purl.obolibrary.org/obo/HP_5200310	Diminishment of social interactions		A reduction in the tendency of a person to display emotional responsiveness or empathy towards others during interpersonal interactions as compared to that person's previous norm.
http://purl.obolibrary.org/obo/HP_5200215	Visceral hallucination	http://purl.obolibrary.org/obo/HP_5200214	Somatic hallucination		A type of hallucination that involves the perception of internal bodily sensations or processes that do not actually exist.
http://purl.obolibrary.org/obo/HP_5200217	Depersonalization	http://purl.obolibrary.org/obo/HP_5200216	Abnormal perceptual state		A psychological experience or symptom characterized by a sense of detachment or estrangement from oneself or one's surroundings.
http://purl.obolibrary.org/obo/HP_5200218	Derealization	http://purl.obolibrary.org/obo/HP_5200216	Abnormal perceptual state		A subjective experience in which an individual feels a sense of detachment or estrangement from their surroundings, leading to a distorted perception of the external world. It is characterized by a feeling of unreality or unfamiliarity with one's environment, as if things are dreamlike, artificial, or lacking in significance.
http://purl.obolibrary.org/obo/HP_5200220	Decreased facial expression mirroring	http://purl.obolibrary.org/obo/HP_4000075	Reduced frequency of facial expressions		Diminished mirroring or reflection of facial expressions in another person during social interactions.
http://purl.obolibrary.org/obo/HP_5200221	Diminishment of comfort with casual physical contact	http://purl.obolibrary.org/obo/HP_5200310	Diminishment of social interactions		A reduction in the tendency of a person to accept casual physical contact with others as compared to that person's previous norm.
http://purl.obolibrary.org/obo/HP_5200227	Thought blocking	http://purl.obolibrary.org/obo/HP_5200419	Disorder of thought control		The experience of sudden cessation of the thought/thinking process, the person often describes the mind going blank and there is frequently a period of silence that is accompanied by a perplexed state, not understanding what transpired. Some may describe the experience as an abrupt emptying of the mind or the belief that an external force removed their thoughts from their head.
http://purl.obolibrary.org/obo/HP_5200231	Hypervigilance	http://purl.obolibrary.org/obo/HP_0100852	Abnormal fear-induced behavior		A heightened alertness is characterized by a broad awareness and/or excessive scanning of environmental stimuli.
http://purl.obolibrary.org/obo/HP_5200233	Anticipatory anxiety	http://purl.obolibrary.org/obo/HP_0000739	Anxiety		A state characterized by future-oriented worry, accompanied by negative affect and autonomic arousal.
http://purl.obolibrary.org/obo/HP_5200234	Flight of ideas	http://purl.obolibrary.org/obo/HP_0025781	Abnormally rapid thought process		Successive thoughts and speech are easily diverted by external stimuli or internal superficial associations. Unable to maintain a constant train of thought and lose themselves in side issues, losing the thread and are unable to recover it. Superficial connections appear to drive the subject matter.
http://purl.obolibrary.org/obo/HP_5200243	Abnormal change in social behavior	http://purl.obolibrary.org/obo/HP_0012433	Abnormal social behavior		An alternation in the habits and emotional tendencies of an individual with a change in behavior that is typically noticed by family members or peers.
http://purl.obolibrary.org/obo/HP_5200265	Pressured speech	http://purl.obolibrary.org/obo/HP_0031434	Abnormal prosody		Speech pattern that is excessive and intense that often imparts a sense of urgency, the individual appears to be driven to communicate with many words that are spoken very quickly and may run into each other. The person is frequently difficult to interrupt and appears to not respond to social cues for the conversational partner(s) to take their turn in speaking.
http://purl.obolibrary.org/obo/HP_5200267	Leaden paralysis	http://purl.obolibrary.org/obo/HP_5200214	Somatic hallucination		The sensation of having heavy arms and legs, or feeling a heaviness in the limbs.
http://purl.obolibrary.org/obo/HP_5200270	Grandiosity	http://purl.obolibrary.org/obo/HP_5200242	Cognitive distortion		Persistently exaggerated feelings and thoughts of an inflated sense of self-importance, superiority, uniqueness, or invulnerability. The affected individual may project arrogance with a dismissive behavioral pattern towards others the individual deems inferior.
http://purl.obolibrary.org/obo/HP_5200271	Hopelessness	http://purl.obolibrary.org/obo/HP_5200242	Cognitive distortion		Persistent and excessive feelings of despair with an overwhelming lack of hope. While hopelessness is primarily a personal experience, the sense of hopelessness becomes pervasive and affects most aspects of the personal experience in relation to the world. For example the person may communicate a sense of hopelessness for family and friends (who themselves do not experience hopelessness), as well as the world in general.
http://purl.obolibrary.org/obo/HP_5200273	Pathological sadness	http://purl.obolibrary.org/obo/HP_0031467	Dysregulated negative emotional state		A negative emotional state characterized by sadness, unhappiness, or sorrow that is excessive in intensity, duration, or resistance to self-regulation compared with culturally appropriate norms or the individual's usual emotional range. It may arise spontaneously or in response to significant life events, but when reactive, it is disproportionate to or persists beyond what is typically expected for the context. Pathological sadness can be associated with feelings of hopelessness, helplessness, anhedonia, and a pessimistic outlook, but these features are not invariably present. It may also be accompanied by increased tearfulness, low energy, cognitive difficulties such as impaired concentration, and somatic changes including disrupted sleep or appetite.
http://purl.obolibrary.org/obo/HP_5200276	Decreased need for sleep	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		There has been a noticeable decrease in the need for sleep, where individuals feel refreshed even with minimal or no sleep.
http://purl.obolibrary.org/obo/HP_5200287	Recurrent distressing nightmares	http://purl.obolibrary.org/obo/HP_0025184	Arousal parasomnia		Repeated occurrence of nightmares that cause clinically significant distress or impairment in social, occupational or other important areas of functioning, which are not attributable to the physiological effects of a substance (e.g. drug abuse or medication) and which cannot be adequately explained by coexisting mental and medical disorders.
http://purl.obolibrary.org/obo/HP_5200288	Sleep-related eating behavior	http://purl.obolibrary.org/obo/HP_0025184	Arousal parasomnia		Eating during sleep with limited to no recall of involuntary eating while asleep.
http://purl.obolibrary.org/obo/HP_5200289	Microsleep	http://purl.obolibrary.org/obo/HP_0025288	Excessive sleep		Sudden onset of extreme drowsiness or falling asleep during the day for a short period of time.
http://purl.obolibrary.org/obo/HP_5200290	Exploding head syndrome	http://purl.obolibrary.org/obo/HP_4000063	Sleep related hallucination		Sleep disorder in which one hears a loud noise or explosive crashing sound in one's head. The sound is not real or heard by anyone else. The episode typically happens suddenly, either when beginning to fall asleep or when waking up during the night.
http://purl.obolibrary.org/obo/HP_5200291	REM sleep behavior disorder	http://purl.obolibrary.org/obo/HP_5200300	Abnormal movement during sleep		REM Sleep Behavior Disorder (RBD) is a chronic sleep condition characterized by dream enactment and loss of REM atonia.
http://purl.obolibrary.org/obo/HP_5200292	Non-restorative sleep	http://purl.obolibrary.org/obo/HP_4000064	Poor sleep		Sleep that is subjectively reported as unrefreshing even though the duration is adequate.
http://purl.obolibrary.org/obo/HP_5200294	Sexsomnia	http://purl.obolibrary.org/obo/HP_0025235	NREM parasomnia		Unintentional sexual behavior during sleep, such as masturbation, initiation of sex, or making sexual noises, is known as sexsomnia. Sexsomnia predominantly occurs during NREM sleep.
http://purl.obolibrary.org/obo/HP_5200295	Periodic limb movements of sleep	http://purl.obolibrary.org/obo/HP_5200300	Abnormal movement during sleep		Repetitive, stereotyped limb movements occurring during sleep, typically involving brief flexion of the toes, ankles, knees, or hips. These movements recur at regular intervals, often every 20-40 seconds, and may cause sleep fragmentation or daytime fatigue. PLMS commonly co-occurs with restless legs syndrome but may also occur independently.
http://purl.obolibrary.org/obo/HP_5200298	Abnormal sleep architecture	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		Interruptions during the various stages of sleep.
http://purl.obolibrary.org/obo/HP_5200299	REM parasomnia	http://purl.obolibrary.org/obo/HP_0025234	Parasomnia		Parasomnia occurs during REM sleep.
http://purl.obolibrary.org/obo/HP_5200304	Short N1 sleep	http://purl.obolibrary.org/obo/HP_5200362	Short NREM sleep		Decreased duration of phase N1 of nonrapid eye movement (NREM) sleep.
http://purl.obolibrary.org/obo/HP_5200305	Paradoxical insomnia	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		Paradoxical insomnia is a condition in which individuals with a normal or near-normal sleep macrostructure tend to severely underestimate the quantity and quality of their sleep.
http://purl.obolibrary.org/obo/HP_5200307	Short N2 sleep	http://purl.obolibrary.org/obo/HP_5200362	Short NREM sleep		Decreased duration of phase N2 of nonrapid eye movement (NREM) sleep.
http://purl.obolibrary.org/obo/HP_5200309	Short N3 sleep	http://purl.obolibrary.org/obo/HP_5200362	Short NREM sleep		Decreased duration of phase N3 of nonrapid eye movement (NREM) sleep.
http://purl.obolibrary.org/obo/HP_5200310	Diminishment of social interactions	http://purl.obolibrary.org/obo/HP_5200243	Abnormal change in social behavior		A reduction in the tendency of a person to seek or maintain social connections or interactions with others compared to previous norms for an individual.
http://purl.obolibrary.org/obo/HP_5200311	Amplification of interpersonal communication	http://purl.obolibrary.org/obo/HP_5200212	Amplification of social interactions		An increase in the tendency of a person to share information or emotions compared to that person's previous norms.
http://purl.obolibrary.org/obo/HP_5200315	Amplification of relationship seeking	http://purl.obolibrary.org/obo/HP_5200212	Amplification of social interactions		Increased frequency or duration in social outings and interactions as part of relationship-seeking or maintenance compared to the previous norms of an individual. May be considered to be overfamiliar and have a tendency to engage strangers in a presumptive manner.
http://purl.obolibrary.org/obo/HP_5200316	Diminishment of interpersonal communication	http://purl.obolibrary.org/obo/HP_5200310	Diminishment of social interactions		A reduction in the tendency of a person to share information or emotions compared to that person's previous norms.
http://purl.obolibrary.org/obo/HP_5200320	Diminishment of relationship seeking	http://purl.obolibrary.org/obo/HP_5200310	Diminishment of social interactions		A reduction in the tendency of a person to seek new interpersonal relationships or maintain existing relationships.
http://purl.obolibrary.org/obo/HP_5200321	Amplification of sexual behavior	http://purl.obolibrary.org/obo/HP_0025793	Abnormal change in sexual drive		An abnormal increase of libido (sexual desire), typically accompanied by a higher frequency of sexual activity compared to from a person's previous norm.
http://purl.obolibrary.org/obo/HP_5200322	Amplification of emotional expression	http://purl.obolibrary.org/obo/HP_5200212	Amplification of social interactions		An increase in the tendency of a person to express emotions compared to that person's previous norm.
http://purl.obolibrary.org/obo/HP_5200323	Amplification of emotional responsiveness	http://purl.obolibrary.org/obo/HP_5200212	Amplification of social interactions		An increase in the tendency of a person to display emotional responsiveness or emotional empathy towards others during interpersonal interactions as compared to that person's previous norm. May be considered to be overreactive or over-engaged with interpersonal situations that may take on a persistent preoccupation and would appear to be relatively unrelated to the person, and beyond the expression of normal empathy.
http://purl.obolibrary.org/obo/HP_5200325	Amplification of comfort with casual physical contact	http://purl.obolibrary.org/obo/HP_5200212	Amplification of social interactions		An increase in the tendency of a person to be comfortable with physical contact with others compared to that person's previous norm. Often considered to be intrusive and encroaching on personal space of others less known to the person, frequently causing discomfort and may result in argument or altercation.
http://purl.obolibrary.org/obo/HP_5200327	Diminishment of sexual behavior	http://purl.obolibrary.org/obo/HP_0025793	Abnormal change in sexual drive		A reduction of libido (sexual desire), typically accompanied by a reduction in the frequency of sexual activity , and/or activity compared to the affected individual's previous state.
http://purl.obolibrary.org/obo/HP_5200328	Diminishment of emotional expression	http://purl.obolibrary.org/obo/HP_5200310	Diminishment of social interactions		A reduction in the tendency of a person to express emotions that is typically noticed as a change in behavior by family members or peers.
http://purl.obolibrary.org/obo/HP_5200330	Suicide behaviors	http://purl.obolibrary.org/obo/HP_0100716	Self-injurious behavior		Suicide attempts or preparations
http://purl.obolibrary.org/obo/HP_5200332	Addictive non-substance behaviors	http://purl.obolibrary.org/obo/HP_0030858	Addictive behavior		Uncontrolled use or problematic behaviors of dependency without the use of drugs or substances can be detrimental.
http://purl.obolibrary.org/obo/HP_5200333	Addictive spending behavior	http://purl.obolibrary.org/obo/HP_5200332	Addictive non-substance behaviors		An uncontrollable urge to shop and spend money can lead to distress or impairment.
http://purl.obolibrary.org/obo/HP_5200334	Addictive gambling behavior	http://purl.obolibrary.org/obo/HP_5200332	Addictive non-substance behaviors		The act of taking chances or engaging in behaviors without restraint, typically involving the wagering of something valuable, in pursuit of acquiring something of higher value.
http://purl.obolibrary.org/obo/HP_5200335	Addictive sex behavior	http://purl.obolibrary.org/obo/HP_5200332	Addictive non-substance behaviors		Inability to control or manage sexual urges, fantasies, or behaviors that impair one's ability to function.
http://purl.obolibrary.org/obo/HP_5200336	Addictive video game use	http://purl.obolibrary.org/obo/HP_5200332	Addictive non-substance behaviors		The inability to regulate persistent gaming behavior is characterized by a heightened prioritization of gaming activities over regular daily tasks and responsibilities.
http://purl.obolibrary.org/obo/HP_5200337	Compulsive stealing	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		Irresistible impulses to take easily affordable items.
http://purl.obolibrary.org/obo/HP_5200338	Excessive fire setting	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		The inability to control urges of deliberately setting fires for pleasure and gratification, without any criminal intent.
http://purl.obolibrary.org/obo/HP_5200339	Self-cutting	http://purl.obolibrary.org/obo/HP_0000742	Self-mutilation		Deliberate harm to one's body, in the form of cutting that results in tissue damage, without a conscious intent to die.
http://purl.obolibrary.org/obo/HP_5200341	Addictive cannabis use	http://purl.obolibrary.org/obo/HP_0033511	Addictive substance use		A persistent and compulsive need to use cannabis, despite negative consequences.
http://purl.obolibrary.org/obo/HP_5200342	Autophagia	http://purl.obolibrary.org/obo/HP_0012169	Self-biting		The habitual action of inflicting pain upon oneself by biting and/or devouring portions of one's body.
http://purl.obolibrary.org/obo/HP_5200352	Hypnagogic sleep paralysis	http://purl.obolibrary.org/obo/HP_0025233	Sleep paralysis		Sleep paralysis that occurs when falling asleep.
http://purl.obolibrary.org/obo/HP_5200353	Hypnopompic sleep paralysis	http://purl.obolibrary.org/obo/HP_5200297	Abnormal transition from wakefulness to sleep		Sleep paralysis that occurs when waking up from sleep.
http://purl.obolibrary.org/obo/HP_5200356	Sleep onset rapid eye movement period	http://purl.obolibrary.org/obo/HP_5200296	Abnormal transition from sleep to wakefulness		Entering REM sleep immediately upon falling asleep.
http://purl.obolibrary.org/obo/HP_5200357	Prolonged N1 sleep	http://purl.obolibrary.org/obo/HP_5200363	Prolonged NREM sleep		Increased duration of phase N1 of nonrapid eye movement (NREM) sleep.
http://purl.obolibrary.org/obo/HP_5200358	Prolonged N2 sleep	http://purl.obolibrary.org/obo/HP_5200363	Prolonged NREM sleep		Increased duration of phase N2 of nonrapid eye movement (NREM) sleep.
http://purl.obolibrary.org/obo/HP_5200359	Prolonged N3 sleep	http://purl.obolibrary.org/obo/HP_5200363	Prolonged NREM sleep		Increased duration of phase N3 of nonrapid eye movement (NREM) sleep.
http://purl.obolibrary.org/obo/HP_5200402	Overvalued idea	http://purl.obolibrary.org/obo/HP_0025785	Abnormal preoccupation		A solitary belief that may be held by others in the society that is maintained by the person to an abnormal and morbid degree and overtly drives behaviors that are considered unhealthy, intrusive, or illegal. This includes fads and cults that the person may adhere to and practice to a morbid degree. The content may vary and ranges from religion, health, romance, or politics.
http://purl.obolibrary.org/obo/HP_5200403	Time agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The inability to perceive the passage of time is usually due to a disorder involving the temporal area of the brain.
http://purl.obolibrary.org/obo/HP_5200405	Olfactory agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The inability to recognize certain smells or types of odors that you previously recognized.
http://purl.obolibrary.org/obo/HP_5200407	Topographical agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The inability to rely on visual cues to guide one's direction is due to the inability to recognize objects.
http://purl.obolibrary.org/obo/HP_5200409	Delusional memory	http://purl.obolibrary.org/obo/HP_0000746	Delusion		Delusional memory is a memory that is false or fantastically distorted, but held with firm and irrefutable conviction despite evidence to the contrary. It is often seen in psychiatric conditions such as delusional disorders, schizophrenia, and sometimes in severe mood disorders. These memories can be completely fabricated or have a basis in an actual event that has been grossly misinterpreted or altered by the individual's mind.
http://purl.obolibrary.org/obo/HP_5200410	Auditory agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The condition is characterized by the inability to recognize spoken languages and/or nonverbal environmental sounds and music, despite having adequate hearing. However, spontaneous speech, reading, and writing abilities remain intact.
http://purl.obolibrary.org/obo/HP_5200411	Gustatory agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		People cannot identify tastes, even though they can experience them.
http://purl.obolibrary.org/obo/HP_5200412	Allesthesia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		Referral of a sensory stimulus from one side of the body to the other.
http://purl.obolibrary.org/obo/HP_5200413	Autotopagnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The loss of the ability to localize, recognize, or identify specific parts of one's body.
http://purl.obolibrary.org/obo/HP_5200415	Persecutory delusion	http://purl.obolibrary.org/obo/HP_0000746	Delusion		False beliefs (or judgements) that are held with extraordinary conviction and subjective certainty that are impervious to other experiences or counterarguments and the content is generally considered impossible for the context and circumstance. Delusional beliefs may arise meaningfully from personal or social experiences, yet are impossible, held with conviction, and irrefutable; more commonly they may be psychologically irreducible, appearing with no logical or meaningful connection to the individual experience.
http://purl.obolibrary.org/obo/HP_5200416	Morbid jealousy	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A disorder of delusional content wherein the affected individual believes they are a victim of their partner's infidelity. It is often based on delusional evidence of an erotic or romantic nature. There may be an affective (mood related) component or may be associated with substance use disorders. It may also occur on its own. There may be associated behaviors to monitor or gather evidence of the perceived infidelity.
http://purl.obolibrary.org/obo/HP_5200417	Grandiose delusion	http://purl.obolibrary.org/obo/HP_0000746	Delusion		Delusional beliefs of a fantastical, expansive, or supernatural quality related to power, ability, wealth, or station. They are often related to origin (aristocratic lineage, royal birth, being raised as a foster child), possessions (owning vast estates, castles, etc., which are withheld through intrigue), abilities (being great inventors, discoverers, artists, possessors of special wisdom, gifted with inspiration), and status (adviser to prominent diplomats, the true director of political destinies). Grandiose delusions may be related to affective states, substance use, or may occur independently.
http://purl.obolibrary.org/obo/HP_5200418	Folie à deux	http://purl.obolibrary.org/obo/HP_0000746	Delusion		Delusional beliefs are transmitted from one individual to another.
http://purl.obolibrary.org/obo/HP_5200419	Disorder of thought control	http://purl.obolibrary.org/obo/HP_0025769	Disordered formal thought process		A false belief that another person, group of people, or external force controls one's general thoughts, feelings, impulses, or behaviors.
http://purl.obolibrary.org/obo/HP_5200420	Delusion of love	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A delusional belief that the person is secretly loved by another individual who is often of recognized fame or authoratative significance. There is typically no overt evidence and the delusional belief may be driven by falsely perceived indicators. Often there is a blend of erotic delusions and morbid infatuation.
http://purl.obolibrary.org/obo/HP_5200421	Nihilistic delusion	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A delusion that elements of the self, body, or world no longer exist. The person typically recognizes that the entity did in fact exist at one time, but has ceased to exist. The cause of which may be related to disease, decay, or may have been removed or taken by unknown forces.
http://purl.obolibrary.org/obo/HP_5200422	Cotard delusion	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A false belief that you or your body parts are dead, dying, or do not exist.
http://purl.obolibrary.org/obo/HP_5200424	Delusional perception	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A true perception, to which a patient attributes a false and usually bizarre meaning or interpretation. It is often a revelatory experience that is sudden and is a profound realization of the delusional belief. It often occurs in the context of delusional mood or atmosphere wherein vague and mysterious hunches or concerns with nebulous meaning evolve into clear, delusional observations, and expresses delusions of reference.
http://purl.obolibrary.org/obo/HP_5200425	Hypochondriac delusion	http://purl.obolibrary.org/obo/HP_0000746	Delusion		Delusion quality to belief that one is suffering from an illness despite reassurances based on medical examination and testing. The person may (or not) express pain or discomfort that they attribute to the disease. They are frequently treatment seeking, but do not induce illness features (which is termed Munchhausen syndrome).
http://purl.obolibrary.org/obo/HP_5200426	Delusions of infestation	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A persistent belief that a person is infested with living or non-living pathogens, such as parasites, insects, or bugs, when no such infestation is present.
http://purl.obolibrary.org/obo/HP_5200427	Delusional atmosphere	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A persistent sense or a hunch that something is different in an imperceptible manner. Typically the perception is one of a sinister, portentous , uncanny, mysterious, or peculiar sense of foreboding in an indefinable way. There is an innate sense of inexplicable self-relevance to the person. There is often a feeling of anticipation, sometimes even excitement, that soon the mystery may be revealed and all the separate parts of their experience will fit together to reveal something immensely significant. The duration of this experience may vary, lasting from hours to days. It may be intermittent over an extended period of time (months to years).
http://purl.obolibrary.org/obo/HP_5200428	Delusional misidentification	http://purl.obolibrary.org/obo/HP_0000746	Delusion		A group of complex, monothematic delusional phenomena in which subjects hold a belief that the identity of a familiar person, object, location, or self has been altered or replaced. The majority of misidentifications are spouses or first degree relatives, i.e. someone well-known to the person.
http://purl.obolibrary.org/obo/HP_5200429	Religious delusion	http://purl.obolibrary.org/obo/HP_0000746	Delusion		Delusions with a religious content that are considered delusional in nature based on how the belief is held and the evidence offered to support it, which is generally considered impossible or fantastical in the cultural setting of the person. It differs from unusual beliefs that are held with tenacity or conviction and are typically associated with other phenomena consistent with mental illness.
http://purl.obolibrary.org/obo/UBERON_8480069	temporofacial region	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		The region at each side of the face comprising the temple and the cheek.
http://purl.obolibrary.org/obo/HP_0040402	Nipple localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to a sign or symptom that is distributed around the nipples or located in the nipples.
http://purl.obolibrary.org/obo/HP_0040403	Breast microcalcification	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		The term breast microcalcification is used to define calcium deposits in the breast with a diameter of less than 1 mm.
http://purl.obolibrary.org/obo/HP_0040404	Architectural distortion of breast	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		Architectural distortion is defined as an architectural disruption of the normal breast that does not have obvious mass opacities, which may be early signs of breast carcinoma.
http://purl.obolibrary.org/obo/HP_0040405	Asymmetric thickening of the nipple-areolar complex	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		Thickening of the skin around the nipple with a distribution that is not equal on all sides.
http://purl.obolibrary.org/obo/HP_0040406	Perimenopausal	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Perimenopause, or the menopausal transition, encompasses that period of time during which physiologic changes mark progression toward a woman's final menstrual period. This phase begins with the onset of menstrual irregularities and continues until a woman reaches menopause, or one year after amenorrhea has occurred. Perimenopause can last for a variable amount of time, the median of which is four years.
http://purl.obolibrary.org/obo/HP_0040407	Mastitis	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		Mastitis is defined as an inflammation of the breast and may or may not be accompanied by infection.
http://purl.obolibrary.org/obo/HP_0040408	Ameliorated by menopause	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by menopause.
http://purl.obolibrary.org/obo/HP_0040409	Fluctuance on palpation	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		Yielding to alternate pressure by palpating fingers so as to suggest that the area being felt contains fluid.
http://purl.obolibrary.org/obo/HP_0040410	History of vasectomy	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		A medical history of having undergone a vasectomy prior to the current presentation.
http://purl.obolibrary.org/obo/HP_0040411	Pain in penis	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the penis.
http://purl.obolibrary.org/obo/HP_0040412	Left ventricular thrombus	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		A blood clot (thrombus) localized in the left ventricle. Left ventricular thrombus is a serious complication of acute myocardial infarction and also of non-ischemic cardiomyopathies.
http://purl.obolibrary.org/obo/HP_0040414	Gelatinous ascites	http://purl.obolibrary.org/obo/HP_0001541	Ascites		A type of ascites characterized by copious amounts of mucinous ascites and mucinous peritoneal implants, leading to progressive obliteration of the peritoneal cavity and intestinal obstruction.
http://purl.obolibrary.org/obo/HP_0040415	Diffuse breast nodularity	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		Breast tissue with a lumpy or ropelike texture.
http://purl.obolibrary.org/obo/HP_0040416	Abnormal urinary nitrogen compound level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The amount of a nitrogen compound in the urine, normalized for urine concentration, is outside of normal limits.
http://purl.obolibrary.org/obo/HP_0040417	Decreased urinary biopterin level	http://purl.obolibrary.org/obo/HP_0040416	Abnormal urinary nitrogen compound level		The amount of biopterin in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0040418	Abnormal urine guanidinoacetic acid level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		The concentration of guanidinoacetic acid in the urine, normalized for urine concentration, is outside normal limits.
http://purl.obolibrary.org/obo/HP_0040419	Elevated urine guanidinoacetic acid level	http://purl.obolibrary.org/obo/HP_0040418	Abnormal urine guanidinoacetic acid level		The concentration of guanidinoacetic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0040420	Decreased urinary neopterin level	http://purl.obolibrary.org/obo/HP_0040416	Abnormal urinary nitrogen compound level		The amount of neopterin in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0040421	Abnormal urinary inosine level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		The amount of inosine in the urine, normalized for urine concentration, is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0040422	Elevated urinary inosine level	http://purl.obolibrary.org/obo/HP_0040421	Abnormal urinary inosine level		The amount of inosine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0040423	Abnormal urinary guanosine level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		The amount of guanosine in the urine, normalized for urine concentration, is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0040424	Elevated urinary guanosine level	http://purl.obolibrary.org/obo/HP_0040423	Abnormal urinary guanosine level		The amount of guanosine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0040426	Decreased urinary hypoxanthine level	http://purl.obolibrary.org/obo/HP_0040425	Abnormal urinary hypoxanthine level		The concentration of hypoxanthine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Any kind of test for an infectious agent in a specimen positive.
http://purl.obolibrary.org/obo/HP_0430031	Aqueous humor viral DNA positivity	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		The presence of viral DNA (e.g., cytomegalovirus, herpes simplex virus, or varicella zoster virus) in the aqueous humor of the eye.
http://purl.obolibrary.org/obo/HP_0430032	Electronic cigarette exposure history	http://purl.obolibrary.org/obo/HP_0430133	Tobacco use history		History of use of electronic cigarettes (vaping).
http://purl.obolibrary.org/obo/HP_0430033	Gottron sign	http://purl.obolibrary.org/obo/HP_0012733	Macule		Erythematous macules or patches over extensor surfaces of elbows, knuckles, knees, and ankles.
http://purl.obolibrary.org/obo/HP_0430034	Hypertension resistant to conventional therapy	http://purl.obolibrary.org/obo/HP_0000822	Hypertension		Resistant hypertension is defined as above-goal elevated blood pressure in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and a diuretic.
http://purl.obolibrary.org/obo/HP_0430035	Tibiofibular interosseous membrane calcification	http://purl.obolibrary.org/obo/HP_0100491	Abnormality of lower limb joint		Deposition of excess calcium in the interosseous membrane of the leg, which extends between the interosseous crests of the tibia and fibula and separates the anterior and posterior muscles of the lower leg.
http://purl.obolibrary.org/obo/HP_0430036	Supracondylar elbow fracture	http://purl.obolibrary.org/obo/HP_0041219	Elbow fracture		A type of elbow fracture that involves the distal humerus just above the elbow.
http://purl.obolibrary.org/obo/HP_0430037	Abnormal alcohol consumption	http://purl.obolibrary.org/obo/HP_0030858	Addictive behavior		Alcohol abuse or dependence.
http://purl.obolibrary.org/obo/HP_0430043	Thoracic lordosis	http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column		Thoracic lordosis refers to an abnormal curvature of the thoracic spine in which the thoracic spine displays lordosis (inward curve) instead of the normal kyphosis (outward curve).
http://purl.obolibrary.org/obo/HP_0430044	Radiation into left arm	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Refers to pain or discomfort that is perceived to travel from the chest into the left arm.
http://purl.obolibrary.org/obo/HP_0430045	Radiation into right arm	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Refers to pain or discomfort that is perceived to travel from the chest into the right arm.
http://purl.obolibrary.org/obo/HP_0430047	Large joint hypermobility	http://purl.obolibrary.org/obo/HP_0001382	Joint hypermobility		The capability that a large joint (or a group of joints) has to move, passively and/or actively, beyond normal limits along physiological axes. Large joints include shoulders, elbows, hips, knees, and ankles.
http://purl.obolibrary.org/obo/HP_6000786	Absent superficial temporal artery pulse	http://purl.obolibrary.org/obo/HP_0032552	Abnormal pulse		The pulsation of the superficial temporal artery cannot be detected on physical examination.
http://purl.obolibrary.org/obo/HP_6000787	Basilar artery fenestration	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		A fenestration affecting the basilar artery. Basilar fenestration typically occurs at the lower end of the basilar artery just as the vertebral arteries join Fenestrations of intracranial arteries are segmental duplications of the lumen into two distinct endothelium-lined channels, which may or may not share their adventitial layer. They can range from a small focus of divided tissue to long-segment duplication. Fenestrations are the result of partial failure of fusion of paired primitive embryologic vessels or incomplete obliteration of different anastomosis in a primitive vascular network. The association of fenestrations with aneurysms has been suggested in many small case series, though the exact relationship is not well defined.
http://purl.obolibrary.org/obo/HP_6000788	Displacement of the extensor tendon in metacarpophalangeal joint	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Dislocation of the extensor tendons from their central position on the metacarpal heads can be traumatic, congenital, spontaneous, or degenerative.
http://purl.obolibrary.org/obo/HP_6000789	Heloma	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A corn, also known as a clavus, heloma, or focal intractable plantar hyperkeratosis, is a type of callosity. Corns are uncomfortable, thickened skin lesions that result from repeated mechanical trauma due to friction or pressure forces.
http://purl.obolibrary.org/obo/HP_6000790	Exacerbated by pronation	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is aggravated by (or made more painful by) pronation. Pronation of the hand involves the rotation of the forearm and wrist so that the palm of the hand faces downwards or towards the back (posteriorly).
http://purl.obolibrary.org/obo/HP_6000791	Distortion of the anterior part of the interhemispheric fissure	http://purl.obolibrary.org/obo/HP_0012703	Abnormal subarachnoid space morphology		Change in the normal shape (displacement, asymmetry) of the anterior part of the interhemispheric fissure. This finding can be identified prenatally by sonography or magnetic resonance imaging.
http://purl.obolibrary.org/obo/HP_6000792	Positive lacrimal tract actinomyces culture	http://purl.obolibrary.org/obo/HP_0430151	Positive respiratory tract infectious agent test		Growth of Actinomyces israelii (anaerobic filamentous gram positive) culture of lacrimal discharge or concretions.
http://purl.obolibrary.org/obo/HP_6000793	Eschar	http://purl.obolibrary.org/obo/HP_0033126	Cutaneous necrosis		A type of wound characterized by dry, black, hard necrotic tissue.
http://purl.obolibrary.org/obo/HP_6000794	History of wearing tightly fitted clothing	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		History of wearing tight clothing such as compression shorts, sports bras, bike shorts, wet suits, spandex, veils, and tight hats.
http://purl.obolibrary.org/obo/HP_6000795	Anti-folate receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against the folate receptor in the blood circulation.
http://purl.obolibrary.org/obo/HP_6000796	Positive bloodstream VDRL test	http://purl.obolibrary.org/obo/HP_0031863	Bloodstream infectious agent		An abnormal (positive) result of the Venereal Disease Research Laboratory (VDRL) test performed in peripheral blood, suggesting past or present syphilis.
http://purl.obolibrary.org/obo/HP_6000797	Positive bloodstream rapid plasma reagin test	http://purl.obolibrary.org/obo/HP_0031863	Bloodstream infectious agent		Positive result of the the rapid plasma reagin test (RPR test. This is a rapid diagnostic test that looks for non-specific antibodies in the blood of the patient that may indicate an infection by syphilis or related non-venereal treponematoses.
http://purl.obolibrary.org/obo/HP_6000798	Positive bloodstream HIV p24 antigen test	http://purl.obolibrary.org/obo/HP_0430109	Positive bloodstream infectious agent antigen test		Demonstration of the p24 antigen of human immunodeficiency virus in the bloodstream.
http://purl.obolibrary.org/obo/HP_6000799	Positive Quantiferon tuberculosis test	http://purl.obolibrary.org/obo/HP_0430109	Positive bloodstream infectious agent antigen test		A positive Quantiferon test result indicating Mycobacterium tuberculosis. The Quantiferon assay is designed to stimulate IFN-gamma release from CD4+ T cells in a single tuberculosis antigen tube using long peptides from three M. tuberculosis antigens.
http://purl.obolibrary.org/obo/HP_6000800	Tzanck smear with multinucleated giant cells	http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test		Tzanck smear demonstrates multinucleated giant cells, a sign that is suggestive for herpetic infections. Such smears are taken from skin lesions and display multinucleated cells with ground glass nuclei, nuclear moulding, and margination of nuclear chromatin typical of herpes simplex and varicella infection.
http://purl.obolibrary.org/obo/HP_6000801	Positive Mazzotti test	http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test		Locally applied 1.6 percent diethylcarbamazine citrate in Nivea lotion can be used as a diagnostic test for onchocerciasis. Papular reactions are considered as positive test results.
http://purl.obolibrary.org/obo/HP_6000802	Positive bloodstream Tropheryma whipplei nucleic acid test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of Tropheryma whipplei in the blood circulation by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000803	Elevated urinary 2,8-dihydroxyadenine level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		The amount of 2,8-dihydroxyadenine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000804	Elevated urine fructose level	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		Amount of fructose in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000805	Elevated urinary uroporphyrin level	http://purl.obolibrary.org/obo/HP_6000535	Elevated urinary porphyrin level		The amount of uroporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000806	Elevated urinary phosphohydroxylysine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of phosphohydroxylysine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000807	Cervical C6/C7 vertebrae fusion	http://purl.obolibrary.org/obo/HP_0002949	Fused cervical vertebrae		Fusion of cervical vertebrae at C6 and C7, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development, leading to a short neck with a low hairline at the back of the head, and restricted mobility of the upper spine.
http://purl.obolibrary.org/obo/HP_6000808	Periumbilical depression	http://purl.obolibrary.org/obo/HP_0001551	Abnormal umbilicus morphology		The tissue that immediately surrounds the umbilicus is located below the normal plane of the abdomen.
http://purl.obolibrary.org/obo/HP_6000809	Thickened tibial cortex	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		Abnormally increased thicknes of the cortical layer of the tibia.
http://purl.obolibrary.org/obo/HP_6000810	Thickened femoral cortex	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		Abnormally increased thicknes of the cortical layer of the femur.
http://purl.obolibrary.org/obo/HP_6000811	Thickened cortex of the radius	http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius		Abnormally increased thickness of the cortical layer of the radius.
http://purl.obolibrary.org/obo/HP_6000812	Thickened cortex of the ulna	http://purl.obolibrary.org/obo/HP_0003957	Cortical thickening of the forearm bones		Abnormally increased thickness of the cortical layer of the ulna.
http://purl.obolibrary.org/obo/HP_6000813	Elevated circulating aspartate aminotransferase to alanine aminotransferase ratio	http://purl.obolibrary.org/obo/HP_0430135	Abnormal circulating hepatic transaminase concentration		Aspartate aminotransferase to alanine aminotransferase ratio increased greater than 1.5.
http://purl.obolibrary.org/obo/HP_6000814	Temporomandibular joint dislocation	http://purl.obolibrary.org/obo/HP_0010754	Abnormality of the temporomandibular joint		The lower jawbone (mandible) pulls away from the temporomandibular joints (TMJ). It is characterized by pain, clicking and functional restriction.
http://purl.obolibrary.org/obo/HP_6000815	Amyloid goiter	http://purl.obolibrary.org/obo/HP_0000853	Goiter		Amyloidosis is defined as the accumulation of amorphous, proteinaceous material in different parts of the body. Amyloid can be deposited in the thyroid gland in such quantities to cause a clinically apparent enlargement of the gland known as Amyloid goiter.
http://purl.obolibrary.org/obo/HP_6000816	Prominent lesser trochanter	http://purl.obolibrary.org/obo/HP_0003366	Abnormal femoral neck/head morphology		Abnormally large lesser trochanter.
http://purl.obolibrary.org/obo/HP_6000817	Melorheostosis	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		Regions of sclerosing hyperostosis in the cortex of long bones, which might have a radiologic appearance of dripping candle wax.
http://purl.obolibrary.org/obo/HP_6000818	Transverse terminal limb defect	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		A congenital anomaly that appears as an amputation at different levels of the extremity. The limb is missing the terminal (distal) segment(s), with preservation of all the segment(s) proximal to the missing segment.
http://purl.obolibrary.org/obo/HP_6000819	Elevated circulating beta-glucuronidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of beta-glucuronidase (EC 3.2.1.31) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000820	Elevated osmolality gap	http://purl.obolibrary.org/obo/HP_6000679	Abnormal serum osmolality		Plasma osmolality is determined mainly by Sodium, its counter ions, and uncharged species such as Glucose and Urea. Knowledge of the plasma concentration of these species allows calculation of the plasma osmolality quite accurately. If the difference between the measured osmolality (MO) and calculated osmolality (CO) is known as the osmolar gap (OG) is large (greater than 15) osmolar gap can help identify the presence in plasma of substances such as ethanol, methanol, isopropanol, ethylene glycol, propylene glycol..
http://purl.obolibrary.org/obo/HP_6000821	Elevated circulating bile alcohol concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		The concentration of bile alcohols in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000822	Elevated CSF tetrahydrobiopterin level	http://purl.obolibrary.org/obo/HP_0040207	Abnormal CSF pterin concentration		Concentration of tetrahydrobiopterin in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000823	Elevated CSF 5-hydroxyindoleacetic acid concentration	http://purl.obolibrary.org/obo/HP_0020019	Abnormal CSF 5-hydroxyindoleacetic acid concentration		The concentration of 5-hydroxyindoleacetic acid in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000824	Cerebrospinal fluid eosinophilia	http://purl.obolibrary.org/obo/HP_0012229	CSF pleocytosis		Presence of at least 10% eosinophils in the total cerebrospinal fluid (CSF) leukocyte count.
http://purl.obolibrary.org/obo/HP_6000825	Reduced C27 3beta-HSD activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of 3beta-hydroxy-delta5-C27-steroid oxidoreductase (C27 3beta-HSD) as measured in cultured fibroblasts is below the limits of normal.
http://purl.obolibrary.org/obo/HP_6000826	Reduced procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1; also known as Lysyl hydroxylase; EC 1.14.11.4) as measured in cultured fibroblasts is below the limits of normal. PLOD1 catalyzes the formation of hydroxylysine in collagens and other proteins with collagen-like amino acid sequences, by the hydroxylation of lysine residues in X-lys-gly sequences.
http://purl.obolibrary.org/obo/HP_6000827	Diminished tissue fumarylacetoacetate hydrolase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of fumarylacetoacetate hydrolase (FAH; EC 3.7.1.2) below the lower limit of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000828	Reduced tissue peptidase D activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of Peptidase D (EC 3.4.13.9; also known as prolidase, imidodipeptidase, proline dipeptidase, and aminoacyl-L-proline hydrolase) below the lower limit of normal. The activity of this enzyme can be measured in erythrocytes, leukocytes, or fibroblasts.
http://purl.obolibrary.org/obo/HP_6000829	Reduced tissue glycine cleavage enzyme activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of the glycine cleavage enzyme below the lower limit of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000830	Diminished alpha-ketoglutarate dehydrogenase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of the alpha-ketoglutarate dehydrogenase complex as measured in cultured fibroblasts is below the limits of normal. This enzyme is a multienzyme complex consisting of 3 protein subunits, oxoglutarate dehydrogenase, also known as alpha-ketoglutarate dehydrogenase or E1k (EC 1.2.4.2.), dihydrolipoyl succinyltransferase (DLST, or E2k; 126063), and dihydrolipoyl dehydrogenase (DLD, or E3; 238331). The complex catalyzes a key reaction in the Krebs tricarboxylic acid cycle.
http://purl.obolibrary.org/obo/HP_6000831	Increased circulating dihydroxycholestanoic acid concentration	http://purl.obolibrary.org/obo/HP_0012202	Increased serum bile acid concentration		The concentration of dihydroxycholestanoic acid (DHCA) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000832	Reduced tissue phosphorylase kinase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of phosphorylase kinase below the lower limit of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000833	Hyperkalemia while symptomatic	http://purl.obolibrary.org/obo/HP_0011042	Abnormal circulating potassium concentration		Increased concentration of potassium in the blood circulation specifically measured during a disease flareup, attack, or exacerbation.
http://purl.obolibrary.org/obo/HP_6000834	Elevated urinary gamma-glutamylcysteine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of gamma-glutamylcysteine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000835	Positive CSF mycobacterial culture	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		Growth of mycobacteria in a culture derived from cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_6000836	Positive respiratory tract nucleic acid pathogen test	http://purl.obolibrary.org/obo/HP_0430151	Positive respiratory tract infectious agent test		Positive (abnormal) result of a sputum or pharyngeal sample test such as polymerase chain reaction that is targeted against a nucleic acid sequence specific for a pathogen.
http://purl.obolibrary.org/obo/HP_6000837	Positive respiratory tract SARS-CoV-2 coronavirus nucleic acid test	http://purl.obolibrary.org/obo/HP_6000836	Positive respiratory tract nucleic acid pathogen test		Detection of SARS-CoV-2 coronavirus nucleic acid in the sputum or pharyngeal sample by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000838	Positive fecal cryptosporidium antigen test	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Cryptosporidium antigen present in stool. Tests include direct fluorescent-antibody (DFA), which detects intact organisms, and enzyme immunoassays (EIAs), which detect soluble stool antigens.
http://purl.obolibrary.org/obo/HP_6000839	Horizontal position of testicle	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		The Bell Clapper deformity is one of the causes for the testicular torsion. In this condition, testis lacks a normal attachment to tunica vaginalis and hangs freely, causing it to sit horizontally rather than vertically in the scrotum.
http://purl.obolibrary.org/obo/HP_6000840	Localized soft-tissue swelling on extremity	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		Abnormal enlargement (swelling) that is restricted to a specific part of a limb.
http://purl.obolibrary.org/obo/HP_6000841	Abnormal scleral thickness	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		Any deviation from the normal height of the sclera, the white part of the eye that forms the tough, fibrous outer layer of the exterior of the eyeball.
http://purl.obolibrary.org/obo/HP_6000842	Multiple eyelid beaded papules	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Multiple beaded papules along the eyelid margins and inner canthus.
http://purl.obolibrary.org/obo/HP_6000843	Nonexudative conjunctivitis	http://purl.obolibrary.org/obo/HP_0000509	Conjunctivitis		A type of conjunctivitis that is not characterized by appreciable exudate, i.e., fluid, cells, or other substances that have escaped from blood vessels and have been deposited around the eyelids.
http://purl.obolibrary.org/obo/HP_6000844	Nematode in retina	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Demonstration of a nematode (roundworm) in the retina, generally by an imaging procedure such as fundoscopy.
http://purl.obolibrary.org/obo/HP_6000845	Vascular compression of the eighth cranial nerve	http://purl.obolibrary.org/obo/HP_0009591	Abnormal vestibulocochlear nerve morphology		A condition in which blood vessels adjacent to the eighth cranial nerve (vestibulocochlear nerve) such as the anterior inferior cerebellar artery abnormally contact or compress the vestibulocochlear nerve as it exits the brainstem or travels within the cerebellopontine angle.
http://purl.obolibrary.org/obo/HP_6000846	Beaded bile ducts	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Multifocal intra- and extra-hepatic bile duct strictures alternating with normal caliber or slightly dilated segments, resembling beads on a string.
http://purl.obolibrary.org/obo/HP_6000847	Cardiac mass	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		An abnormal enlargement or swelling localized in the heart. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000848	Superior olive hypertrophy	http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology		Abnormal increase in size of the superior olive, also known as the superior olivary complex. The superior olive is a collection of brainstem nuclei that is located in pons, functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.
http://purl.obolibrary.org/obo/HP_6000849	Spinal extradural arachnoid cyst	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		Spinal extradural arachnoid cyst is a cyst in the spinal canal that protrudes into the epidural space from a defect in the dura mater.
http://purl.obolibrary.org/obo/HP_6000850	Temporal cortex localization	http://purl.obolibrary.org/obo/HP_0430127	Brain localization		Localization to or predominance in the temporal cortex of the brain.
http://purl.obolibrary.org/obo/HP_6000851	Basilar meningeal enhancement	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		Abnormal enhancement of CT or MIR contrast medium in the basilar meninges, that is, those located in the basal cisterns or spaces at the base of the brain, due to increased permeability of blood vessels in these areas.
http://purl.obolibrary.org/obo/HP_6000853	Thyroid cyst	http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology		A fluid-filled sac or cavity that develops due to fluid accumulation within the thyroid tissue.
http://purl.obolibrary.org/obo/HP_6000854	Decreased circulating sulfate concentration	http://purl.obolibrary.org/obo/HP_0020330	Abnormal circulating inorganic anion concentration		The concentration of sulfate in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000855	Cold intolerance	http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation		The inability to maintain a comfortable body temperature in a cold environment or cold temperatures.
http://purl.obolibrary.org/obo/HP_6000856	Head and neck distribution	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in (or predominant in) the head and neck region.
http://purl.obolibrary.org/obo/HP_6000857	Symmetric distribution	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that is highly similar on the left and right sides of the body.
http://purl.obolibrary.org/obo/HP_6000858	Muscle extensor surface location	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in extensor surface of an extremity.
http://purl.obolibrary.org/obo/HP_6000859	Dermal foam cells	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Presence of lipid-laden macrophages (foam cells) in the inner layer of the skin (dermis).
http://purl.obolibrary.org/obo/HP_6000860	Diminished tissue very long-chain acyl-CoA dehydrogenase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Diminished activity of Very long-chain acyl-CoA dehydrogenase (VLCAD), an enzyme that catalyzes the initial step of mitochondrial beta-oxidation of long-chain fatty acids with a chain length of 14 to 20 carbons. VLCAD activity can be measured with biochemical testing using cultured fibroblasts or lymphocytes.
http://purl.obolibrary.org/obo/HP_6000861	Diminished tissue glycogen branching enzyme activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of glycogen branching enzyme in tissues below the lower limit of normal. The activity can be measured in multiple tissues including culutured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000862	Parotid adenoma	http://purl.obolibrary.org/obo/HP_0100684	Salivary gland neoplasm		A benign tumor of the parotid salivary gland.
http://purl.obolibrary.org/obo/HP_6000863	Elevated serum-ascites albumin gradient (SAAG)	http://purl.obolibrary.org/obo/HP_0025032	Abnormality of digestive system physiology		An elevation of the serum ascites albumin gradient (SAAG), which is based on the difference between the albumin level of serum and of ascitic fluid, may be used to assess the extent of ascites. The SAAG is thought to reflect the colloid osmotic pressure gradient and the degree of portal hypertension. It has been shown that SAAG is a better discriminator of portal hypertension than ascites. A SAAG of 1.1 gm/dL or higher is considered as high, indicating the presence of portal hypertension, while SAAG less than 1.1 gm/dL is low, indicating the absence of portal hypertension.
http://purl.obolibrary.org/obo/HP_6000864	Transverse smile	http://purl.obolibrary.org/obo/HP_0030319	Weakness of facial musculature		Inability to raise the corners of the mouth during the act of smiling due to facial muscle weakness. The act of smiling is accompanied by a horizontal movement of the mouth.
http://purl.obolibrary.org/obo/HP_6000865	Hyperphalangy of the 4th finger	http://purl.obolibrary.org/obo/HP_0030367	Finger hyperphalangy		An accessory phalanx of the fourth (ring) finger that is arranged linearly with the other phalanges. Hyperphalangy results from an accessory ossification center at the metacarpophalangeal joint.
http://purl.obolibrary.org/obo/HP_6000866	Delayed distal femoral epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0010590	Abnormality of the distal femoral epiphysis		Developmental delay of ossification of the distal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_6000867	Delayed tibial epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0006508	Abnormality of tibial epiphyses		Developmental delay of ossification of an epiphysis of the tibia.
http://purl.obolibrary.org/obo/HP_6000868	Toe hyperphalangy	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		Hyperphalangy is a digit morphology in which increased numbers of phalanges are arranged linearly within a toe. That is, there is an accessory phalanx that is arranged linearly with the other phalanges.
http://purl.obolibrary.org/obo/HP_6000869	Sclerotic ilium	http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology		An elevation in bone density in the ilium. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_6000870	Metaphyseal chevron deformity	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		The chevron sign refers to an inverted V-shape metaphyses. It is most commonly seen in the distal femur and tends to disappear with age.
http://purl.obolibrary.org/obo/HP_6000871	Popcorn calcification	http://purl.obolibrary.org/obo/HP_0010655	Epiphyseal stippling		Popcorn calcifications are areas of amorphous calcifications often with rings and arcs that resemble popped corn kernels in the metaphysis and epiphysis around the growth plate.
http://purl.obolibrary.org/obo/HP_6000872	Aplasia/Hypoplasia of the calvaria	http://purl.obolibrary.org/obo/HP_0009116	Aplasia/Hypoplasia involving bones of the skull		A developmental defect characterized by absence or underdevelopment of the calvaria.
http://purl.obolibrary.org/obo/HP_6000873	Bowdler spurs	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		Transverse long bone midshaft spurs or osteochondral projections typically occuring in the fibulae and less commonly in the forearms.
http://purl.obolibrary.org/obo/HP_6000874	Delayed ossification of the clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		Delayed maturation and calcification of the clavicle.
http://purl.obolibrary.org/obo/HP_6000875	Wide sacroiliac joint	http://purl.obolibrary.org/obo/HP_0100781	Abnormal sacroiliac joint morphology		Distance between the sacrum and the ilium bones of the pelvis at the sacroiliac joint is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000876	Anti-Glutamate Receptor delta2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against glutamate receptor delta2.
http://purl.obolibrary.org/obo/HP_6000877	Anti-dachshund family transcription factor 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against dachshund-homolog 1 (DACH1) autoantigen.
http://purl.obolibrary.org/obo/HP_6000878	Anti-potassium channel tetramerization domain containing 16 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against potassium channel tetramerization domain containing 16 (KCTD16).
http://purl.obolibrary.org/obo/HP_6000879	Anti-regulator of G protein signaling 8 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against regulator of G-protein signaling 8 (RGS8).
http://purl.obolibrary.org/obo/HP_6000880	Anti-neurochondrin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against neurochondrin .
http://purl.obolibrary.org/obo/HP_6000881	Anti-DCC netrin 1 receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against Netrin-1 receptors DCC (deleted in colorectal carcinoma).
http://purl.obolibrary.org/obo/HP_6000882	Anti-recoverin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against recoverin. Recoverins are calcium-binding proteins primarily expressed in retinal rod photoreceptors and primarily involved in phototransduction.
http://purl.obolibrary.org/obo/HP_6000883	Recent history of sedation by propofol infusion	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A history of exposure to anesthesia by propofanol infusion recently before the presenting complaint.
http://purl.obolibrary.org/obo/HP_6000884	Enlarged humeral head	http://purl.obolibrary.org/obo/HP_0003887	Abnormal humeral head morphology		Size (volume) of the head of the humerus above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000885	Enlarged radial head	http://purl.obolibrary.org/obo/HP_0003995	Abnormality of the radial head		Size (volume) of the head of the radius above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000886	Enlarged distal tibial epiphysis	http://purl.obolibrary.org/obo/HP_0010592	Abnormality of the distal tibial epiphysis		Size (volume) of the distal epiphysis of the tiba above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000887	Elevated blood bismuth concentration	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		The concentration of bismuth in the blood is above the upper limit of a guidance value for total blood bismuth concentrations that implies possible injurious effects.
http://purl.obolibrary.org/obo/HP_6000888	Elevated urine bismuth level	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of a level of bismuth in the urine high enough to raise the suspicion of bismuth toxicity, usually greater than 20microgram per deciliter.
http://purl.obolibrary.org/obo/HP_6000889	Distal radioulnar joint dislocation	http://purl.obolibrary.org/obo/HP_0006439	Radioulnar dislocation		Distal radioulnar joint dislocation is more commonly displaced dorsally (i.e. the distal ulna is dorsally dislocated with respect to the distal radius), but can be volarly displaced.
http://purl.obolibrary.org/obo/HP_6000890	Proximal radioulnar joint dislocation	http://purl.obolibrary.org/obo/HP_0006439	Radioulnar dislocation		he proximal radioulnar translocation means that both the radius and ulna are dislocated from the humerus.
http://purl.obolibrary.org/obo/HP_6000891	Absent toe phalanx flexion crease	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Absence of one or more interphalangeal creases of a toe (i.e., of the transverse lines in the skin between the phalanges of the toes).
http://purl.obolibrary.org/obo/HP_6000892	White matter globoid cells	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		Multinucleated phagocytes in the cerebral white matter, typically are 10-15 micrometers in diameter, that contain fatty filamentous inclusions that stain positive for periodic acid-Schiff (PAS), which may be phagocytized myelin, as these cells are often found in proximity to sites where demyelination is prominent. Globoid cells have been to thought to originate from CNS resident microglia and/or infiltrating peripheral macrophages.
http://purl.obolibrary.org/obo/HP_6000893	Gaucher cells	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		Glucosylceramide forms fibrillar aggregates that accumulate in macrophages and result in the cell cytoplasm presenting a characteristic crumpled tissue paper appearance. These cells, known as Gaucher cells, infiltrate various organs (e.g., bone marrow, spleen, and liver) and are responsible for the major signs of Gaucher disease.
http://purl.obolibrary.org/obo/HP_6000894	Breast adenoma	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		A benign, well circumscribed neoplasm that arises from the breast.
http://purl.obolibrary.org/obo/HP_6000895	Breast apocrine adenoma	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		A type of breast adenoma composed of benign apocrine cells.
http://purl.obolibrary.org/obo/HP_6000896	Fibrocystic breast lesion	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		A type of benign cyst or cysts in breast tissue that are typically mobile within the glandular breast tissue, chest wall, and skin and are rubber-like in texture. The main histological features are an extracellular matrix of collagen, peri canalicular patterns of stromal cells with the presence of florid epithelial hyperplasia.
http://purl.obolibrary.org/obo/HP_6000897	Pancreatic VIPoma	http://purl.obolibrary.org/obo/HP_0002894	Neoplasm of the pancreas		A type of neuroendocrine tumor that originates in the pancreas and secretes excessive amounts of vasoactive intestinal peptide (VIP).
http://purl.obolibrary.org/obo/HP_6000898	Gastric carcinoid tumor	http://purl.obolibrary.org/obo/HP_0100570	Carcinoid tumor		Originating from enterochromaffin-like cells, gastric carcinoid tumors are rare tumors that develop within the gastric mucosa. They can present as an isolated lesion or there can be multiple lesions. The tumor can invade locally into deeper structures of the gastrointestinal tract wall. Solitary gastric carcinoids have a greater chance for the development of malignancy and metastasis as compared to multiple gastric carcinoids due to hypergastrinemia.
http://purl.obolibrary.org/obo/HP_6000946	Transverse terminal lower limb defect	http://purl.obolibrary.org/obo/HP_6000818	Transverse terminal limb defect		A congenital anomaly that appears as an amputation at different levels of the leg, e.g. femur, foreleg, ankle or toe. The limb is missing the terminal (distal) segment(s), with preservation of all the segment(s) proximal to the missing segment.
http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology	http://purl.obolibrary.org/obo/HP_0003019	Abnormality of the wrist		Any structural anomaly of the wrist.
http://purl.obolibrary.org/obo/CHEBI_746933	globular protein	http://purl.obolibrary.org/obo/CHEBI_36080	protein		Protein characterized by a compact, spherical shape and generally soluble in water
http://purl.obolibrary.org/obo/CHEBI_747325	additive	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		a role for a chemical additive to a mixture
http://purl.obolibrary.org/obo/UBERON_8500005	facial tubercle	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		The facial tuberosity (tuber faciale) is a prominence located on the facial surface of the maxilla; it finishes the facial crest and varies much according to the species.
http://purl.obolibrary.org/obo/UBERON_8850001	epithelium of anorectum	http://purl.obolibrary.org/obo/UBERON_0001278	epithelium of large intestine		The epithelium that lines the anorectum.
http://purl.obolibrary.org/obo/CHEBI_15551	prostaglandin E2	http://purl.obolibrary.org/obo/CHEBI_26338	prostaglandins E		Prostaglandin F<small><sub>2α</sub></small> in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E<small><sub>2</sub></small> is the most common and most biologically potent of mammalian prostaglandins.
http://purl.obolibrary.org/obo/CHEBI_15611	sarcosine	http://purl.obolibrary.org/obo/CHEBI_66933	N-alkylglycine		A <em>N</em>-alkylglycine that is the <em>N</em>-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine.
http://purl.obolibrary.org/obo/CHEBI_15681	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide	http://purl.obolibrary.org/obo/CHEBI_79209	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide		A sialodiosylceramide consisting of the trisaccharide α-Neu5Ac-(2→3)-β-<small>D</small>-Gal-(1→4)-β-<small>D</small>-Glc attached to the primary hydroxy function of ceramide.
http://purl.obolibrary.org/obo/CHEBI_15801	(R)-2-hydroxyglutarate(2-)	http://purl.obolibrary.org/obo/CHEBI_11596	2-hydroxyglutarate(2-)		A 2-hydroxyglutarate(2−) that has (2<i>R</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_16004	(R)-lactate	http://purl.obolibrary.org/obo/CHEBI_24996	lactate		An optically active form of lactate having (<i>R</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_16651	(S)-lactate	http://purl.obolibrary.org/obo/CHEBI_24996	lactate		An optically active form of lactate having (<i>S</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_16782	(S)-2-hydroxyglutarate(2-)	http://purl.obolibrary.org/obo/CHEBI_11596	2-hydroxyglutarate(2-)		A 2-hydroxyglutarate(2−) that has (2<i>S</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_16831	3-hydroxy-3-methylglutaric acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in <em>Crotalaria dura</em>.
http://purl.obolibrary.org/obo/CHEBI_17126	carnitine	http://purl.obolibrary.org/obo/CHEBI_22860	amino-acid betaine		An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4.
http://purl.obolibrary.org/obo/CHEBI_17375	(2S)-2-hydroxy monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_49302	2-hydroxy monocarboxylic acid		A 2-hydroxy monocarboxylic acid in which the carbon at position 2 has (<i>S</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_17893	(2R)-2-hydroxy monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_49302	2-hydroxy monocarboxylic acid		A 2-hydroxy monocarboxylic acid having (2<i>R</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_17968	butyrate	http://purl.obolibrary.org/obo/CHEBI_78115	fatty acid anion 4:0		A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_18089	N-benzoylglycine	http://purl.obolibrary.org/obo/CHEBI_16180	N-acylglycine		An <em>N</em>-acylglycine in which the acyl group is specified as benzoyl.
http://purl.obolibrary.org/obo/CHEBI_18243	dopamine	http://purl.obolibrary.org/obo/CHEBI_33567	catecholamine		Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
http://purl.obolibrary.org/obo/CHEBI_25830	p-quinones	http://purl.obolibrary.org/obo/CHEBI_36141	quinone		A quinone in which the two oxo groups of the quinone are located <em>para</em> to each other on the 6-membered quinonoid ring.
http://purl.obolibrary.org/obo/CHEBI_26912	oxolanes	http://purl.obolibrary.org/obo/CHEBI_38104	oxacycle		Any oxacycle having an oxolane (tetrahydrofuran) skeleton.
http://purl.obolibrary.org/obo/CHEBI_27300	vitamin D	http://purl.obolibrary.org/obo/CHEBI_36853	hydroxy seco-steroid		Any member of a group of fat-soluble hydroxy seco-steroids that exhibit biological activity against vitamin D deficiency. Vitamin D  can be obtained from sun exposure, food and supplements and is biologically inactive and converted into the biologically active calcitriol via double hydroxylation in the body.
http://purl.obolibrary.org/obo/CHEBI_31011	valerate	http://purl.obolibrary.org/obo/CHEBI_58954	straight-chain saturated fatty acid anion		A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals.
http://purl.obolibrary.org/obo/CHEBI_33566	catechols	http://purl.obolibrary.org/obo/CHEBI_33570	benzenediols		Any compound containing an <em>o</em>-diphenol component.
http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated.
http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		Any monocarboxylic acid anion carrying at least one hydroxy substituent.
http://purl.obolibrary.org/obo/CHEBI_36699	corticosteroid hormone	http://purl.obolibrary.org/obo/CHEBI_50858	corticosteroid		Any of a class of steroid hormones that are produced in the adrenal cortex.
http://purl.obolibrary.org/obo/CHEBI_36834	3-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_35350	hydroxy steroid		Any hydroxy steroid carrying a hydroxy group at position 3.
http://purl.obolibrary.org/obo/CHEBI_37054	3-hydroxybutyrate	http://purl.obolibrary.org/obo/CHEBI_84196	3-hydroxy fatty acid anion		A hydroxy fatty acid anion that is the conjugate base of 3-hydroxybutyric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_50113	androgen	http://purl.obolibrary.org/obo/CHEBI_50112	sex hormone		A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.
http://purl.obolibrary.org/obo/CHEBI_50114	estrogen	http://purl.obolibrary.org/obo/CHEBI_50112	sex hormone		A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
http://purl.obolibrary.org/obo/CHEBI_50523	butenolide	http://purl.obolibrary.org/obo/CHEBI_37581	gamma-lactone		A γ-lactone that consists of a 2-furanone skeleton and its substituted derivatives.
http://purl.obolibrary.org/obo/CHEBI_50646	bone density conservation agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
http://purl.obolibrary.org/obo/CHEBI_58314	(2R)-2-hydroxy monocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		A hydroxy monocarboxylic acid anion where the hydroxy group is placed at position 2 (α to the carboxy group) and has (<i>R</i>)-stereochemistry; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58945	organophosphate oxoanion	http://purl.obolibrary.org/obo/CHEBI_26079	phosphoric acid derivative		An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated.
http://purl.obolibrary.org/obo/CHEBI_59554	medium-chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid with a chain length of between C<small><sub>6</sub></small> and C<small><sub>12</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_62761	tyrosine derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of tyrosine at the amino group or the carboxy group, any substitution of phenyl hydrogens, or from the replacement of any hydrogen of tyrosine by a heteroatom. The definition normally excludes peptides containing tyrosine residues.
http://purl.obolibrary.org/obo/CHEBI_64708	one-carbon compound	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		An organic molecular entity containing a single carbon atom (C<small><sub>1</sub></small>).
http://purl.obolibrary.org/obo/CHEBI_71666	gamma-amino acid anion	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		An amino-acid anion in which the amino group is situated γ- to the carboxylate group.
http://purl.obolibrary.org/obo/HP_0040299	Decreased circulating free fatty acid level	http://purl.obolibrary.org/obo/HP_0040300	Abnormal circulating free fatty acid concentration		
http://purl.obolibrary.org/obo/HP_0003070	Elbow ankylosis	http://purl.obolibrary.org/obo/HP_0031013	Ankylosis		
http://purl.obolibrary.org/obo/HP_0003938	Synostosis involving the elbow	http://purl.obolibrary.org/obo/HP_0100238	Synostosis involving bones of the upper limbs		
http://purl.obolibrary.org/obo/HP_0003940	Osteoarthritis of the elbow	http://purl.obolibrary.org/obo/HP_0002758	Osteoarthritis		
http://purl.obolibrary.org/obo/HP_0003941	Stippled calcification of the elbow	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		
http://purl.obolibrary.org/obo/HP_0003942	Synovial chondromatosis of the elbow	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		
http://purl.obolibrary.org/obo/HP_0003943	Abnormality of the joint spaces of the elbow	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		
http://purl.obolibrary.org/obo/HP_0003945	Irregular articular surfaces of the elbow joints	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		
http://purl.obolibrary.org/obo/HP_0003946	Abnormal elbow epiphysis morphology	http://purl.obolibrary.org/obo/HP_0003839	Abnormal upper limb epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003949	Abnormal elbow metaphysis morphology	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0100744	Abnormality of the humeroradial joint	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		
http://purl.obolibrary.org/obo/HP_0002996	Limited elbow movement	http://purl.obolibrary.org/obo/HP_0001376	Limitation of joint mobility		
http://purl.obolibrary.org/obo/CHEBI_38795	pteroic acids	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_26373	pteridines	http://purl.obolibrary.org/obo/CHEBI_33833	heteroarene		
http://purl.obolibrary.org/obo/CHEBI_22728	benzopyrrole	http://purl.obolibrary.org/obo/CHEBI_38180	polycyclic heteroarene		
http://purl.obolibrary.org/obo/CHEBI_35350	hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		
http://purl.obolibrary.org/obo/CHEBI_35789	oxo steroid	http://purl.obolibrary.org/obo/CHEBI_17087	ketone		
http://purl.obolibrary.org/obo/CHEBI_35788	seco-steroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		
http://purl.obolibrary.org/obo/CHEBI_35508	steroid fundamental parent	http://purl.obolibrary.org/obo/CHEBI_35507	natural product fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_188923	C29-steroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		
http://purl.obolibrary.org/obo/CHEBI_38304	diazolidine	http://purl.obolibrary.org/obo/CHEBI_25693	organic heteromonocyclic compound		
http://purl.obolibrary.org/obo/CHEBI_46775	N-alkylpyrrolidine	http://purl.obolibrary.org/obo/CHEBI_50996	tertiary amino compound		
http://purl.obolibrary.org/obo/CHEBI_38275	pyrrolidinone	http://purl.obolibrary.org/obo/CHEBI_38260	pyrrolidines		
http://purl.obolibrary.org/obo/CHEBI_46773	hydroxypyrrolidine	http://purl.obolibrary.org/obo/CHEBI_38260	pyrrolidines		
http://purl.obolibrary.org/obo/CHEBI_33670	heteromonocyclic compound	http://purl.obolibrary.org/obo/CHEBI_33661	monocyclic compound		
http://purl.obolibrary.org/obo/CHEBI_26375	pterins	http://purl.obolibrary.org/obo/CHEBI_26373	pteridines		
http://purl.obolibrary.org/obo/CHEBI_26288	propanediol	http://purl.obolibrary.org/obo/CHEBI_13643	glycol		
http://purl.obolibrary.org/obo/CHEBI_32879	propane	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		
http://purl.obolibrary.org/obo/CHEBI_23622	deoxygalactose	http://purl.obolibrary.org/obo/CHEBI_23628	deoxyhexose		
http://purl.obolibrary.org/obo/CHEBI_33892	iron coordination entity	http://purl.obolibrary.org/obo/CHEBI_33861	transition element coordination entity		
http://purl.obolibrary.org/obo/CHEBI_35115	elemental manganese	http://purl.obolibrary.org/obo/CHEBI_25154	manganese molecular entity		
http://purl.obolibrary.org/obo/CHEBI_35219	plant growth retardant	http://purl.obolibrary.org/obo/CHEBI_26155	plant growth regulator		
http://purl.obolibrary.org/obo/CHEBI_33721	carbohydrate acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_232876	N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose(1-)	http://purl.obolibrary.org/obo/CHEBI_33721	carbohydrate acid anion		
http://purl.obolibrary.org/obo/CHEBI_24734	hydroxyphenylalanine	http://purl.obolibrary.org/obo/CHEBI_25985	phenylalanine derivative		
http://purl.obolibrary.org/obo/CHEBI_24163	galactoside	http://purl.obolibrary.org/obo/CHEBI_35313	hexoside		
http://purl.obolibrary.org/obo/CHEBI_20664	5beta-cholane	http://purl.obolibrary.org/obo/CHEBI_35519	cholane		
http://purl.obolibrary.org/obo/CHEBI_36300	tricarboxylic acid dianion	http://purl.obolibrary.org/obo/CHEBI_35753	tricarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_49302	2-hydroxy monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35868	hydroxy monocarboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_27171	organic heterobicyclic compound	http://purl.obolibrary.org/obo/CHEBI_33672	heterobicyclic compound		
http://purl.obolibrary.org/obo/CHEBI_22727	benzopyran	http://purl.obolibrary.org/obo/CHEBI_38104	oxacycle		
http://purl.obolibrary.org/obo/CHEBI_36278	cholanic acids	http://purl.obolibrary.org/obo/CHEBI_36078	cholanoid		
http://purl.obolibrary.org/obo/CHEBI_21619	N-acetylneuraminates	http://purl.obolibrary.org/obo/CHEBI_21663	N-acylneuraminates		
http://purl.obolibrary.org/obo/CHEBI_22984	calcium atom	http://purl.obolibrary.org/obo/CHEBI_22313	alkaline earth metal atom		
http://purl.obolibrary.org/obo/CHEBI_25107	magnesium atom	http://purl.obolibrary.org/obo/CHEBI_22313	alkaline earth metal atom		
http://purl.obolibrary.org/obo/CHEBI_26216	potassium atom	http://purl.obolibrary.org/obo/CHEBI_22314	alkali metal atom		
http://purl.obolibrary.org/obo/CHEBI_26708	sodium atom	http://purl.obolibrary.org/obo/CHEBI_22314	alkali metal atom		
http://purl.obolibrary.org/obo/CHEBI_30356	isobutyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_45557	sec-butyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_20899	D-alloisoleucine	http://purl.obolibrary.org/obo/CHEBI_16733	D-alpha-amino acid		
http://purl.obolibrary.org/obo/CHEBI_23905	monoatomic anion	http://purl.obolibrary.org/obo/CHEBI_24867	monoatomic ion		
http://purl.obolibrary.org/obo/CHEBI_24834	inorganic anion	http://purl.obolibrary.org/obo/CHEBI_36914	inorganic ion		
http://purl.obolibrary.org/obo/CHEBI_38443	1-benzopyran	http://purl.obolibrary.org/obo/CHEBI_22727	benzopyran		
http://purl.obolibrary.org/obo/CHEBI_35735	dicarboxylic acid monoamide	http://purl.obolibrary.org/obo/CHEBI_23690	dicarboxylic acid amide		
http://purl.obolibrary.org/obo/CHEBI_25213	metal cation	http://purl.obolibrary.org/obo/CHEBI_36915	inorganic cation		
http://purl.obolibrary.org/obo/CHEBI_36526	acidic glycosphingolipid	http://purl.obolibrary.org/obo/CHEBI_24402	glycosphingolipid		
http://purl.obolibrary.org/obo/CHEBI_33280	molecular messenger	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		
http://purl.obolibrary.org/obo/CHEBI_52208	biophysical role	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		
http://purl.obolibrary.org/obo/CHEBI_24860	iodine molecular entity	http://purl.obolibrary.org/obo/CHEBI_24471	halogen molecular entity		
http://purl.obolibrary.org/obo/CHEBI_23116	chlorine atom	http://purl.obolibrary.org/obo/CHEBI_24473	halogen		
http://purl.obolibrary.org/obo/CHEBI_38166	organic heteropolycyclic compound	http://purl.obolibrary.org/obo/CHEBI_33671	heteropolycyclic compound		
http://purl.obolibrary.org/obo/CHEBI_25693	organic heteromonocyclic compound	http://purl.obolibrary.org/obo/CHEBI_33670	heteromonocyclic compound		
http://purl.obolibrary.org/obo/CHEBI_36914	inorganic ion	http://purl.obolibrary.org/obo/CHEBI_24870	ion		
http://purl.obolibrary.org/obo/CHEBI_49637	hydrogen atom	http://purl.obolibrary.org/obo/CHEBI_33559	s-block element atom		
http://purl.obolibrary.org/obo/CHEBI_23906	monoatomic cation	http://purl.obolibrary.org/obo/CHEBI_36916	cation		
http://purl.obolibrary.org/obo/CHEBI_24867	monoatomic ion	http://purl.obolibrary.org/obo/CHEBI_33238	monoatomic entity		
http://purl.obolibrary.org/obo/CHEBI_25699	organic ion	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33515	transition element cation	http://purl.obolibrary.org/obo/CHEBI_25213	metal cation		
http://purl.obolibrary.org/obo/CHEBI_39124	calcium ion	http://purl.obolibrary.org/obo/CHEBI_35155	elemental calcium		
http://purl.obolibrary.org/obo/CHEBI_21663	N-acylneuraminates	http://purl.obolibrary.org/obo/CHEBI_25506	neuraminates		
http://purl.obolibrary.org/obo/CHEBI_36520	oligoglycosylceramide	http://purl.obolibrary.org/obo/CHEBI_17761	ceramide		
http://purl.obolibrary.org/obo/CHEBI_24473	halogen	http://purl.obolibrary.org/obo/CHEBI_33560	p-block element atom		
http://purl.obolibrary.org/obo/CHEBI_25555	nitrogen atom	http://purl.obolibrary.org/obo/CHEBI_33300	pnictogen		
http://purl.obolibrary.org/obo/CHEBI_25805	oxygen atom	http://purl.obolibrary.org/obo/CHEBI_33303	chalcogen		
http://purl.obolibrary.org/obo/CHEBI_27594	carbon atom	http://purl.obolibrary.org/obo/CHEBI_33306	carbon group element atom		
http://purl.obolibrary.org/obo/CHEBI_28659	phosphorus atom	http://purl.obolibrary.org/obo/CHEBI_33300	pnictogen		
http://purl.obolibrary.org/obo/CHEBI_36360	phosphorus oxoacids and derivatives	http://purl.obolibrary.org/obo/CHEBI_26082	phosphorus molecular entity		
http://purl.obolibrary.org/obo/CHEBI_25216	metalloporphyrin	http://purl.obolibrary.org/obo/CHEBI_33909	metallotetrapyrrole		
http://purl.obolibrary.org/obo/CHEBI_25046	linear tetrapyrrole	http://purl.obolibrary.org/obo/CHEBI_26932	tetrapyrrole		
http://purl.obolibrary.org/obo/CHEBI_36309	cyclic tetrapyrrole	http://purl.obolibrary.org/obo/CHEBI_47882	cyclic polypyrrole		
http://purl.obolibrary.org/obo/CHEBI_25508	neuraminic acids	http://purl.obolibrary.org/obo/CHEBI_63394	ketoaldonic acid derivative		
http://purl.obolibrary.org/obo/CHEBI_23443	cyclic amide	http://purl.obolibrary.org/obo/CHEBI_32988	amide		
http://purl.obolibrary.org/obo/CHEBI_25585	nonmetal atom	http://purl.obolibrary.org/obo/CHEBI_33250	atom		
http://purl.obolibrary.org/obo/CHEBI_33559	s-block element atom	http://purl.obolibrary.org/obo/CHEBI_33250	atom		
http://purl.obolibrary.org/obo/CHEBI_26217	potassium molecular entity	http://purl.obolibrary.org/obo/CHEBI_33296	alkali metal molecular entity		
http://purl.obolibrary.org/obo/CHEBI_26712	sodium molecular entity	http://purl.obolibrary.org/obo/CHEBI_33296	alkali metal molecular entity		
http://purl.obolibrary.org/obo/CHEBI_22985	calcium molecular entity	http://purl.obolibrary.org/obo/CHEBI_33299	alkaline earth molecular entity		
http://purl.obolibrary.org/obo/CHEBI_25108	magnesium molecular entity	http://purl.obolibrary.org/obo/CHEBI_33299	alkaline earth molecular entity		
http://purl.obolibrary.org/obo/CHEBI_26082	phosphorus molecular entity	http://purl.obolibrary.org/obo/CHEBI_33302	pnictogen molecular entity		
http://purl.obolibrary.org/obo/CHEBI_51143	nitrogen molecular entity	http://purl.obolibrary.org/obo/CHEBI_33302	pnictogen molecular entity		
http://purl.obolibrary.org/obo/CHEBI_25806	oxygen molecular entity	http://purl.obolibrary.org/obo/CHEBI_33304	chalcogen molecular entity		
http://purl.obolibrary.org/obo/CHEBI_22313	alkaline earth metal atom	http://purl.obolibrary.org/obo/CHEBI_33559	s-block element atom		
http://purl.obolibrary.org/obo/CHEBI_22314	alkali metal atom	http://purl.obolibrary.org/obo/CHEBI_33559	s-block element atom		
http://purl.obolibrary.org/obo/CHEBI_22744	benzyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_23378	copper cation	http://purl.obolibrary.org/obo/CHEBI_37404	elemental copper		
http://purl.obolibrary.org/obo/CHEBI_24875	iron cation	http://purl.obolibrary.org/obo/CHEBI_82663	elemental iron		
http://purl.obolibrary.org/obo/CHEBI_25155	manganese cation	http://purl.obolibrary.org/obo/CHEBI_35115	elemental manganese		
http://purl.obolibrary.org/obo/CHEBI_33306	carbon group element atom	http://purl.obolibrary.org/obo/CHEBI_33560	p-block element atom		
http://purl.obolibrary.org/obo/CHEBI_24471	halogen molecular entity	http://purl.obolibrary.org/obo/CHEBI_33675	p-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33582	carbon group molecular entity	http://purl.obolibrary.org/obo/CHEBI_33675	p-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_25154	manganese molecular entity	http://purl.obolibrary.org/obo/CHEBI_33743	manganese group molecular entity		
http://purl.obolibrary.org/obo/CHEBI_24873	iron molecular entity	http://purl.obolibrary.org/obo/CHEBI_33744	iron group molecular entity		
http://purl.obolibrary.org/obo/CHEBI_23390	cobalt-corrinoid hexaamide	http://purl.obolibrary.org/obo/CHEBI_33906	cobalt corrinoid		
http://purl.obolibrary.org/obo/CHEBI_33906	cobalt corrinoid	http://purl.obolibrary.org/obo/CHEBI_33890	cobalt coordination entity		
http://purl.obolibrary.org/obo/CHEBI_26124	phytosteroid	http://purl.obolibrary.org/obo/CHEBI_35350	hydroxy steroid		
http://purl.obolibrary.org/obo/CHEBI_26773	stigmastane	http://purl.obolibrary.org/obo/CHEBI_35508	steroid fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_35509	androstane	http://purl.obolibrary.org/obo/CHEBI_35508	steroid fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_35516	cholestane	http://purl.obolibrary.org/obo/CHEBI_35508	steroid fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_35519	cholane	http://purl.obolibrary.org/obo/CHEBI_35508	steroid fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_8386	pregnane	http://purl.obolibrary.org/obo/CHEBI_35508	steroid fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_23966	estrane	http://purl.obolibrary.org/obo/CHEBI_35508	steroid fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_35902	oxo monocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_36238	5beta-cholanic acid	http://purl.obolibrary.org/obo/CHEBI_36237	cholanic acid		
http://purl.obolibrary.org/obo/CHEBI_33909	metallotetrapyrrole	http://purl.obolibrary.org/obo/CHEBI_36309	cyclic tetrapyrrole		
http://purl.obolibrary.org/obo/CHEBI_36359	phosphorus oxoacid derivative	http://purl.obolibrary.org/obo/CHEBI_33241	oxoacid derivative		
http://purl.obolibrary.org/obo/CHEBI_36508	glycotriaosylceramide	http://purl.obolibrary.org/obo/CHEBI_36520	oligoglycosylceramide		
http://purl.obolibrary.org/obo/CHEBI_36915	inorganic cation	http://purl.obolibrary.org/obo/CHEBI_36916	cation		
http://purl.obolibrary.org/obo/CHEBI_50312	onium compound	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		
http://purl.obolibrary.org/obo/CHEBI_38497	respiratory-chain inhibitor	http://purl.obolibrary.org/obo/CHEBI_38496	electron-transport chain inhibitor		
http://purl.obolibrary.org/obo/CHEBI_24863	iodophenol	http://purl.obolibrary.org/obo/CHEBI_37142	organoiodine compound		
http://purl.obolibrary.org/obo/CHEBI_41402	carboxymethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50330	2-amino-2-oxoethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50339	4-aminobutyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_23019	carbonyl group	http://purl.obolibrary.org/obo/CHEBI_51422	organodiyl group		
http://purl.obolibrary.org/obo/CHEBI_22297	alditol phosphate	http://purl.obolibrary.org/obo/CHEBI_26816	carbohydrate phosphate		
http://purl.obolibrary.org/obo/CHEBI_25506	neuraminates	http://purl.obolibrary.org/obo/CHEBI_63561	ketoaldonate derivative		
http://purl.obolibrary.org/obo/CHEBI_38261	imidazolidines	http://purl.obolibrary.org/obo/CHEBI_38304	diazolidine		
http://purl.obolibrary.org/obo/CHEBI_38794	pteroic acid	http://purl.obolibrary.org/obo/CHEBI_38795	pteroic acids		
http://purl.obolibrary.org/obo/CHEBI_38496	electron-transport chain inhibitor	http://purl.obolibrary.org/obo/CHEBI_76932	pathway inhibitor		
http://purl.obolibrary.org/obo/HP_0040298	Hyperplasia of the endometrium	http://purl.obolibrary.org/obo/HP_0030126	Abnormal endometrium morphology		
http://purl.obolibrary.org/obo/HP_0006304	Widely-spaced incisors	http://purl.obolibrary.org/obo/HP_0000699	Diastema		
http://purl.obolibrary.org/obo/UBERON_0035006	preputial swelling of female	http://purl.obolibrary.org/obo/UBERON_0035004	preputial swelling		
http://purl.obolibrary.org/obo/HP_0020124	Echopraxia	http://purl.obolibrary.org/obo/HP_6000768	Echophenomenon		
http://purl.obolibrary.org/obo/PATO_0002142	bracket	http://purl.obolibrary.org/obo/PATO_0000052	shape		
http://purl.obolibrary.org/obo/PATO_0002062	physical quality of a process	http://purl.obolibrary.org/obo/PATO_0001236	process quality		
http://purl.obolibrary.org/obo/PATO_0002143	sloped downward	http://purl.obolibrary.org/obo/PATO_0001481	sloped		
http://purl.obolibrary.org/obo/HP_0031412	Abnormal telomere morphology	http://purl.obolibrary.org/obo/HP_0031411	Abnormal chromosome morphology		
http://purl.obolibrary.org/obo/HP_0031495	Mucinous neoplasm	http://purl.obolibrary.org/obo/HP_0031493	Glandular cell neoplasm		
http://purl.obolibrary.org/obo/HP_0006706	Cystic liver disease	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		
http://purl.obolibrary.org/obo/HP_0008736	Hypoplasia of penis	http://purl.obolibrary.org/obo/HP_0000050	Hypoplastic male external genitalia		
http://purl.obolibrary.org/obo/HP_0002050	Macroorchidism, postpubertal	http://purl.obolibrary.org/obo/HP_0000053	Macroorchidism		
http://purl.obolibrary.org/obo/HP_0000065	Labial hypertrophy	http://purl.obolibrary.org/obo/HP_0000058	Abnormal labia morphology		
http://purl.obolibrary.org/obo/HP_0000066	Labial hypoplasia	http://purl.obolibrary.org/obo/HP_0012815	Hypoplastic female external genitalia		
http://purl.obolibrary.org/obo/HP_0003248	Gonadal tissue inappropriate for external genitalia or chromosomal sex	http://purl.obolibrary.org/obo/HP_0000062	Ambiguous genitalia		
http://purl.obolibrary.org/obo/HP_0000064	Hypoplastic labia minora	http://purl.obolibrary.org/obo/HP_0012880	Abnormal labia minora morphology		
http://purl.obolibrary.org/obo/HP_0011277	Abnormality of the urinary system physiology	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the urinary system		
http://purl.obolibrary.org/obo/HP_0000144	Decreased fertility	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of reproductive system physiology		
http://purl.obolibrary.org/obo/HP_0003517	Birth length greater than 97th percentile	http://purl.obolibrary.org/obo/HP_0000098	Tall stature		
http://purl.obolibrary.org/obo/HP_0000800	Cystic renal dysplasia	http://purl.obolibrary.org/obo/HP_0000107	Renal cyst		
http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		
http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		
http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		
http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology	http://purl.obolibrary.org/obo/HP_0000137	Abnormality of the ovary		
http://purl.obolibrary.org/obo/HP_0000147	Polycystic ovaries	http://purl.obolibrary.org/obo/HP_0000138	Ovarian cyst		
http://purl.obolibrary.org/obo/HP_0000786	Primary amenorrhea	http://purl.obolibrary.org/obo/HP_0000141	Amenorrhea		
http://purl.obolibrary.org/obo/HP_0000869	Secondary amenorrhea	http://purl.obolibrary.org/obo/HP_0000141	Amenorrhea		
http://purl.obolibrary.org/obo/HP_0040413	Atrophic vaginal mucosa	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		
http://purl.obolibrary.org/obo/HP_0000789	Infertility	http://purl.obolibrary.org/obo/HP_0000144	Decreased fertility		
http://purl.obolibrary.org/obo/HP_0000868	Decreased fertility in females	http://purl.obolibrary.org/obo/HP_0000144	Decreased fertility		
http://purl.obolibrary.org/obo/HP_0011337	Abnormality of mouth size	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		
http://purl.obolibrary.org/obo/HP_0100737	Abnormal hard palate morphology	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		
http://purl.obolibrary.org/obo/HP_0040295	Duplication of the upper lip	http://purl.obolibrary.org/obo/HP_0000177	Abnormal upper lip morphology		
http://purl.obolibrary.org/obo/HP_0002055	Curved linear dimple below the lower lip	http://purl.obolibrary.org/obo/HP_0000178	Abnormal lower lip morphology		
http://purl.obolibrary.org/obo/HP_0000216	Broad secondary alveolar ridge	http://purl.obolibrary.org/obo/HP_0000187	Broad alveolar ridges		
http://purl.obolibrary.org/obo/HP_0000198	Absence of Stensen duct	http://purl.obolibrary.org/obo/HP_0000197	Abnormal parotid gland morphology		
http://purl.obolibrary.org/obo/HP_0040309	Increased size of the mandible	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		
http://purl.obolibrary.org/obo/HP_0010753	Midline defect of mandible	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		
http://purl.obolibrary.org/obo/HP_0002003	Large forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		
http://purl.obolibrary.org/obo/HP_0002010	Narrow maxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		
http://purl.obolibrary.org/obo/HP_0002054	Heavy supraorbital ridges	http://purl.obolibrary.org/obo/HP_0000336	Prominent supraorbital ridges		
http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology	http://purl.obolibrary.org/obo/HP_0000366	Abnormality of the nose		
http://purl.obolibrary.org/obo/HP_0002265	Large fleshy ears	http://purl.obolibrary.org/obo/HP_0000400	Macrotia		
http://purl.obolibrary.org/obo/HP_0000454	Flared nostrils	http://purl.obolibrary.org/obo/HP_0000429	Abnormal morphology of the nasal alae		
http://purl.obolibrary.org/obo/HP_0000451	Triangular nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		
http://purl.obolibrary.org/obo/HP_0100691	Abnormality of the curvature of the cornea	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		
http://purl.obolibrary.org/obo/HP_0040051	Abnormality of upper eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		
http://purl.obolibrary.org/obo/HP_0040052	Abnormality of lower eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		
http://purl.obolibrary.org/obo/HP_0200102	Sparse or absent eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		
http://purl.obolibrary.org/obo/HP_0001123	Visual field defect	http://purl.obolibrary.org/obo/HP_0000505	Visual impairment		
http://purl.obolibrary.org/obo/HP_0001135	Chorioretinal dystrophy	http://purl.obolibrary.org/obo/HP_0000556	Retinal dystrophy		
http://purl.obolibrary.org/obo/HP_0000661	Palpebral fissure narrowing on adduction	http://purl.obolibrary.org/obo/HP_0000581	Blepharophimosis		
http://purl.obolibrary.org/obo/HP_0001138	Optic neuropathy	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		
http://purl.obolibrary.org/obo/HP_0008058	Aplasia/Hypoplasia of the optic nerve	http://purl.obolibrary.org/obo/HP_0008057	Aplasia/Hypoplasia affecting the fundus		
http://purl.obolibrary.org/obo/HP_0000607	Periorbital wrinkles	http://purl.obolibrary.org/obo/HP_0100678	Premature skin wrinkling		
http://purl.obolibrary.org/obo/HP_0000727	Frontal lobe dementia	http://purl.obolibrary.org/obo/HP_0000726	Dementia		
http://purl.obolibrary.org/obo/HP_0002439	Frontolimbic dementia	http://purl.obolibrary.org/obo/HP_0000726	Dementia		
http://purl.obolibrary.org/obo/HP_0000753	Autism with high cognitive abilities	http://purl.obolibrary.org/obo/HP_0000729	Autistic behavior		
http://purl.obolibrary.org/obo/HP_0000749	Paroxysmal bursts of laughter	http://purl.obolibrary.org/obo/HP_0000748	Inappropriate laughter		
http://purl.obolibrary.org/obo/HP_0003009	Enhanced neurotoxicity of vincristine	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		
http://purl.obolibrary.org/obo/HP_0003382	Hypertrophic nerve changes	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		
http://purl.obolibrary.org/obo/HP_0003405	Diffuse axonal swelling	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		
http://purl.obolibrary.org/obo/HP_0003406	Peripheral nerve compression	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		
http://purl.obolibrary.org/obo/HP_0003434	Sensory ataxic neuropathy	http://purl.obolibrary.org/obo/HP_0000763	Sensory neuropathy		
http://purl.obolibrary.org/obo/HP_0005257	Thoracic hypoplasia	http://purl.obolibrary.org/obo/HP_0000765	Abnormal thorax morphology		
http://purl.obolibrary.org/obo/HP_0000884	Prominent sternum	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		
http://purl.obolibrary.org/obo/HP_0006714	Aplasia/Hypoplasia of the sternum	http://purl.obolibrary.org/obo/HP_0006711	Aplasia/Hypoplasia involving bones of the thorax		
http://purl.obolibrary.org/obo/HP_0040059	Calcification of ribs	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		
http://purl.obolibrary.org/obo/HP_0006712	Aplasia/Hypoplasia of the ribs	http://purl.obolibrary.org/obo/HP_0006711	Aplasia/Hypoplasia involving bones of the thorax		
http://purl.obolibrary.org/obo/HP_0006713	Aplasia/Hypoplasia of the scapulae	http://purl.obolibrary.org/obo/HP_0006711	Aplasia/Hypoplasia involving bones of the thorax		
http://purl.obolibrary.org/obo/HP_0003251	Male infertility	http://purl.obolibrary.org/obo/HP_0012041	Decreased fertility in males		
http://purl.obolibrary.org/obo/HP_0003247	Overgrowth of external genitalia	http://purl.obolibrary.org/obo/HP_0000811	Abnormal external genitalia morphology		
http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		
http://purl.obolibrary.org/obo/HP_0000875	Episodic hypertension	http://purl.obolibrary.org/obo/HP_0000822	Hypertension		
http://purl.obolibrary.org/obo/HP_0040086	Abnormal prolactin level	http://purl.obolibrary.org/obo/HP_0000830	Anterior hypopituitarism		
http://purl.obolibrary.org/obo/HP_0000857	Neonatal insulin-dependent diabetes mellitus	http://purl.obolibrary.org/obo/HP_0000831	Insulin-resistant diabetes mellitus		
http://purl.obolibrary.org/obo/HP_0000877	Insulin-resistant diabetes mellitus at puberty	http://purl.obolibrary.org/obo/HP_0000831	Insulin-resistant diabetes mellitus		
http://purl.obolibrary.org/obo/HP_0001580	Pigmented micronodular adrenocortical disease	http://purl.obolibrary.org/obo/HP_0000849	Adrenocortical abnormality		
http://purl.obolibrary.org/obo/HP_0000910	Wide-cupped costochondral junctions	http://purl.obolibrary.org/obo/HP_0000919	Abnormality of the costochondral junction		
http://purl.obolibrary.org/obo/HP_0008518	Aplasia/Hypoplasia involving the vertebral column	http://purl.obolibrary.org/obo/HP_0009122	Aplasia/hypoplasia affecting bones of the axial skeleton		
http://purl.obolibrary.org/obo/HP_0040010	Small posterior fossa	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		
http://purl.obolibrary.org/obo/HP_0040011	Flat posterior fossa	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		
http://purl.obolibrary.org/obo/HP_0000931	Thinning and bulging of the posterior fossa bones	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		
http://purl.obolibrary.org/obo/HP_0003868	Humeral cortical thickening	http://purl.obolibrary.org/obo/HP_0010629	Abnormal morphology of the cortex of the humerus		
http://purl.obolibrary.org/obo/HP_0040160	Generalized osteoporosis	http://purl.obolibrary.org/obo/HP_0000939	Osteoporosis		
http://purl.obolibrary.org/obo/HP_0040161	Localized osteoporosis	http://purl.obolibrary.org/obo/HP_0000939	Osteoporosis		
http://purl.obolibrary.org/obo/HP_0000941	Short diaphyses	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0002810	Dumbbell-shaped metaphyses	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003562	Abnormal metaphyseal vascular invasion	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation	http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0001039	Atheroeruptive xanthoma	http://purl.obolibrary.org/obo/HP_0000991	Xanthomatosis		
http://purl.obolibrary.org/obo/HP_0001038	Warfarin-induced skin necrosis	http://purl.obolibrary.org/obo/HP_0001005	Dermatological manifestations of systemic disorders		
http://purl.obolibrary.org/obo/HP_0001050	Plethora	http://purl.obolibrary.org/obo/HP_0001005	Dermatological manifestations of systemic disorders		
http://purl.obolibrary.org/obo/HP_0001053	Hypopigmented skin patches	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		
http://purl.obolibrary.org/obo/HP_0007513	Generalized hypopigmentation	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0001043	Prominent scalp veins	http://purl.obolibrary.org/obo/HP_3000036	Abnormal head blood vessel morphology		
http://purl.obolibrary.org/obo/HP_0001042	High axial triradius	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0001076	Glabellar hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		
http://purl.obolibrary.org/obo/HP_0001040	Multiple pterygia	http://purl.obolibrary.org/obo/HP_0001059	Pterygium		
http://purl.obolibrary.org/obo/HP_0008059	Aplasia/Hypoplasia of the macula	http://purl.obolibrary.org/obo/HP_0008061	Aplasia/Hypoplasia of the retina		
http://purl.obolibrary.org/obo/HP_0001129	Large central visual field defect	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		
http://purl.obolibrary.org/obo/HP_0000145	Transverse vaginal septum	http://purl.obolibrary.org/obo/HP_0001153	Septate vagina		
http://purl.obolibrary.org/obo/HP_0001421	Abnormality of the musculature of the hand	http://purl.obolibrary.org/obo/HP_0001446	Abnormality of the musculature of the upper limbs		
http://purl.obolibrary.org/obo/HP_0006257	Abnormality of carpal bone ossification	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		
http://purl.obolibrary.org/obo/HP_0040039	Onycholysis of fingernails	http://purl.obolibrary.org/obo/HP_0001806	Onycholysis		
http://purl.obolibrary.org/obo/HP_0002073	Progressive cerebellar ataxia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		
http://purl.obolibrary.org/obo/HP_0002470	Nonprogressive cerebellar ataxia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		
http://purl.obolibrary.org/obo/HP_0002497	Spastic ataxia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		
http://purl.obolibrary.org/obo/HP_0002501	Spasticity of pharyngeal muscles	http://purl.obolibrary.org/obo/HP_0001257	Spasticity		
http://purl.obolibrary.org/obo/HP_0002141	Gait imbalance	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		
http://purl.obolibrary.org/obo/HP_0002317	Unsteady gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		
http://purl.obolibrary.org/obo/HP_0002527	Falls	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		
http://purl.obolibrary.org/obo/HP_0003397	Generalized hypotonia due to defect at the neuromuscular junction	http://purl.obolibrary.org/obo/HP_0003398	Abnormal synaptic transmission at the neuromuscular junction		
http://purl.obolibrary.org/obo/HP_0001293	Cranial nerve compression	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		
http://purl.obolibrary.org/obo/HP_0002326	Transient ischemic attack	http://purl.obolibrary.org/obo/HP_0002637	Cerebral ischemia		
http://purl.obolibrary.org/obo/HP_0002448	Progressive encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		
http://purl.obolibrary.org/obo/HP_0002350	Cerebellar cyst	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		
http://purl.obolibrary.org/obo/HP_0007352	Cerebellar calcifications	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		
http://purl.obolibrary.org/obo/HP_0007360	Aplasia/Hypoplasia of the cerebellum	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		
http://purl.obolibrary.org/obo/HP_0003739	Myoclonic spasms	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		
http://purl.obolibrary.org/obo/HP_0001386	Joint swelling	http://purl.obolibrary.org/obo/HP_0000969	Edema		
http://purl.obolibrary.org/obo/HP_0003040	Arthropathy	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		
http://purl.obolibrary.org/obo/HP_0009810	Abnormality of upper limb joint	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		
http://purl.obolibrary.org/obo/HP_0100491	Abnormality of lower limb joint	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		
http://purl.obolibrary.org/obo/HP_0002828	Multiple joint contractures	http://purl.obolibrary.org/obo/HP_0001371	Flexion contracture		
http://purl.obolibrary.org/obo/HP_0045087	Hip joint hypermobility	http://purl.obolibrary.org/obo/HP_0430047	Large joint hypermobility		
http://purl.obolibrary.org/obo/HP_0001374	Congenital hip dislocation	http://purl.obolibrary.org/obo/HP_0002827	Hip dislocation		
http://purl.obolibrary.org/obo/HP_0002611	Cholestatic liver disease	http://purl.obolibrary.org/obo/HP_0001396	Cholestasis		
http://purl.obolibrary.org/obo/HP_0001399	Hepatic failure	http://purl.obolibrary.org/obo/HP_0001410	Decreased liver function		
http://purl.obolibrary.org/obo/HP_0001465	Amyotrophy involving the shoulder musculature	http://purl.obolibrary.org/obo/HP_0001435	Abnormality of the shoulder girdle musculature		
http://purl.obolibrary.org/obo/HP_0001430	Abnormal calf musculature morphology	http://purl.obolibrary.org/obo/HP_0001437	Abnormality of the musculature of the lower limbs		
http://purl.obolibrary.org/obo/HP_0001441	Abnormality thigh musculature morphology	http://purl.obolibrary.org/obo/HP_0001437	Abnormality of the musculature of the lower limbs		
http://purl.obolibrary.org/obo/HP_0001457	Abnormality of the musculature of the upper arm	http://purl.obolibrary.org/obo/HP_0001454	Abnormality of the upper arm		
http://purl.obolibrary.org/obo/HP_0009128	Aplasia/Hypoplasia involving the musculature of the extremities	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		
http://purl.obolibrary.org/obo/HP_0001443	Abnormality of the gluteal musculature	http://purl.obolibrary.org/obo/HP_0001469	Abnormal morphology of the pelvis musculature		
http://purl.obolibrary.org/obo/HP_0001445	Abnormality of the hip-girdle musculature	http://purl.obolibrary.org/obo/HP_0001469	Abnormal morphology of the pelvis musculature		
http://purl.obolibrary.org/obo/HP_0001471	Aplasia/Hypoplasia of the musculature of the pelvis	http://purl.obolibrary.org/obo/HP_0001469	Abnormal morphology of the pelvis musculature		
http://purl.obolibrary.org/obo/HP_0033795	Growth without growth hormone	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		
http://purl.obolibrary.org/obo/HP_0100625	Enlarged thorax	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		
http://purl.obolibrary.org/obo/HP_0040170	Abnormality of hair growth	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		
http://purl.obolibrary.org/obo/HP_0001686	Loss of voice	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		
http://purl.obolibrary.org/obo/HP_0003338	Focal necrosis of right ventricular muscle cells	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		
http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology	http://purl.obolibrary.org/obo/HP_0001732	Abnormality of the pancreas		
http://purl.obolibrary.org/obo/HP_0006494	Aplasia/Hypoplasia involving bones of the feet	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		
http://purl.obolibrary.org/obo/HP_0009134	Osteolysis involving bones of the feet	http://purl.obolibrary.org/obo/HP_0009139	Osteolysis involving bones of the lower limbs		
http://purl.obolibrary.org/obo/HP_0009136	Duplication involving bones of the feet	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		
http://purl.obolibrary.org/obo/HP_0009140	Synostosis involving bones of the feet	http://purl.obolibrary.org/obo/HP_0009138	Synostosis involving bones of the lower limbs		
http://purl.obolibrary.org/obo/HP_0040034	Abnormality of the second metatarsal bone	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		
http://purl.obolibrary.org/obo/HP_0001440	Metatarsal synostosis	http://purl.obolibrary.org/obo/HP_0100265	Synostosis of metacarpals/metatarsals		
http://purl.obolibrary.org/obo/HP_0001449	Duplication of metatarsal bones	http://purl.obolibrary.org/obo/HP_0009136	Duplication involving bones of the feet		
http://purl.obolibrary.org/obo/HP_0001870	Acroosteolysis of distal phalanges (feet)	http://purl.obolibrary.org/obo/HP_0010189	Osteolytic defects of the distal phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0002601	Paresis of extensor muscles of the big toe	http://purl.obolibrary.org/obo/HP_0002460	Distal muscle weakness		
http://purl.obolibrary.org/obo/HP_0001930	Nonspherocytic hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		
http://purl.obolibrary.org/obo/HP_0001937	Microangiopathic hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		
http://purl.obolibrary.org/obo/HP_0001934	Persistent bleeding after trauma	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		
http://purl.obolibrary.org/obo/HP_0001891	Iron deficiency anemia	http://purl.obolibrary.org/obo/HP_0001931	Hypochromic anemia		
http://purl.obolibrary.org/obo/HP_0001958	Nonketotic hypoglycemia	http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia		
http://purl.obolibrary.org/obo/HP_0001998	Neonatal hypoglycemia	http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia		
http://purl.obolibrary.org/obo/HP_0002173	Hypoglycemic seizures	http://purl.obolibrary.org/obo/HP_0011145	Symptomatic seizures		
http://purl.obolibrary.org/obo/HP_0003162	Fasting hypoglycemia	http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia		
http://purl.obolibrary.org/obo/HP_0001949	Hypokalemic alkalosis	http://purl.obolibrary.org/obo/HP_0001948	Alkalosis		
http://purl.obolibrary.org/obo/HP_0001960	Hypokalemic metabolic alkalosis	http://purl.obolibrary.org/obo/HP_0200114	Metabolic alkalosis		
http://purl.obolibrary.org/obo/HP_0001951	Episodic ammonia intoxication	http://purl.obolibrary.org/obo/HP_0001987	Hyperammonemia		
http://purl.obolibrary.org/obo/HP_0000320	Bird-like facies	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		
http://purl.obolibrary.org/obo/HP_0011334	Facial shape deformation	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		
http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		
http://purl.obolibrary.org/obo/HP_0002041	Intractable diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		
http://purl.obolibrary.org/obo/HP_0007364	Aplasia/Hypoplasia of the cerebrum	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		
http://purl.obolibrary.org/obo/HP_0002097	Emphysema	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		
http://purl.obolibrary.org/obo/HP_0002390	Spinal arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		
http://purl.obolibrary.org/obo/HP_0100561	Spinal cord lesion	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		
http://purl.obolibrary.org/obo/HP_0002371	Loss of speech	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		
http://purl.obolibrary.org/obo/HP_0002465	Poor speech	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		
http://purl.obolibrary.org/obo/HP_0002546	Incomprehensible speech	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		
http://purl.obolibrary.org/obo/HP_0000658	Eyelid apraxia	http://purl.obolibrary.org/obo/HP_0031879	Abnormal eyelid physiology		
http://purl.obolibrary.org/obo/HP_0002478	Progressive spastic quadriplegia	http://purl.obolibrary.org/obo/HP_0002191	Progressive spasticity		
http://purl.obolibrary.org/obo/HP_0001549	Abnormal ileum morphology	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		
http://purl.obolibrary.org/obo/HP_0002256	Small bowel diverticula	http://purl.obolibrary.org/obo/HP_0005222	Bowel diverticulosis		
http://purl.obolibrary.org/obo/HP_0040292	Left hemiplegia	http://purl.obolibrary.org/obo/HP_0002301	Hemiplegia		
http://purl.obolibrary.org/obo/HP_0040293	Right hemiplegia	http://purl.obolibrary.org/obo/HP_0002301	Hemiplegia		
http://purl.obolibrary.org/obo/HP_0007374	Atrophy/Degeneration involving the caudate nucleus	http://purl.obolibrary.org/obo/HP_0007369	Atrophy/Degeneration affecting the cerebrum		
http://purl.obolibrary.org/obo/HP_0002512	Brain stem compression	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		
http://purl.obolibrary.org/obo/HP_0007362	Aplasia/Hypoplasia of the brainstem	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		
http://purl.obolibrary.org/obo/HP_0003269	Sudanophilic leukodystrophy	http://purl.obolibrary.org/obo/HP_0002415	Leukodystrophy		
http://purl.obolibrary.org/obo/HP_0003392	First dorsal interossei muscle weakness	http://purl.obolibrary.org/obo/HP_0002460	Distal muscle weakness		
http://purl.obolibrary.org/obo/HP_0003810	Late-onset distal muscle weakness	http://purl.obolibrary.org/obo/HP_0002460	Distal muscle weakness		
http://purl.obolibrary.org/obo/HP_0007372	Atrophy/Degeneration involving the corticospinal tracts	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		
http://purl.obolibrary.org/obo/HP_5200360	Short REM sleep	http://purl.obolibrary.org/obo/HP_5200298	Abnormal sleep architecture		
http://purl.obolibrary.org/obo/HP_5200361	Prolonged REM sleep	http://purl.obolibrary.org/obo/HP_5200298	Abnormal sleep architecture		
http://purl.obolibrary.org/obo/HP_0007109	Periventricular cysts	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		
http://purl.obolibrary.org/obo/HP_0200101	Decreased/absent ankle reflexes	http://purl.obolibrary.org/obo/HP_0002522	Areflexia of lower limbs		
http://purl.obolibrary.org/obo/HP_0002590	Paralytic ileus	http://purl.obolibrary.org/obo/HP_0002595	Ileus		
http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		
http://purl.obolibrary.org/obo/HP_0001404	Hepatocellular necrosis	http://purl.obolibrary.org/obo/HP_0002605	Hepatic necrosis		
http://purl.obolibrary.org/obo/HP_0002642	Arteriovenous fistulas of celiac and mesenteric vessels	http://purl.obolibrary.org/obo/HP_0004947	Arteriovenous fistula		
http://purl.obolibrary.org/obo/HP_0005293	Venous insufficiency	http://purl.obolibrary.org/obo/HP_0002624	Abnormal venous morphology		
http://purl.obolibrary.org/obo/HP_0002654	Multiple epiphyseal dysplasia	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		
http://purl.obolibrary.org/obo/HP_0002656	Epiphyseal dysplasia	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0002657	Spondylometaphyseal dysplasia	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		
http://purl.obolibrary.org/obo/HP_0002864	Paraganglioma of head and neck	http://purl.obolibrary.org/obo/HP_0002668	Paraganglioma		
http://purl.obolibrary.org/obo/HP_0040304	Duplication of the sella turcica	http://purl.obolibrary.org/obo/HP_0002679	Abnormal sella turcica morphology		
http://purl.obolibrary.org/obo/HP_0002681	Deformed sella turcica	http://purl.obolibrary.org/obo/HP_0002679	Abnormal sella turcica morphology		
http://purl.obolibrary.org/obo/HP_0002678	Skull asymmetry	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		
http://purl.obolibrary.org/obo/HP_0000930	Elevated imprint of the transverse sinuses	http://purl.obolibrary.org/obo/HP_0002693	Abnormal skull base morphology		
http://purl.obolibrary.org/obo/HP_0002737	Thick skull base	http://purl.obolibrary.org/obo/HP_0002693	Abnormal skull base morphology		
http://purl.obolibrary.org/obo/HP_0003729	Enteroviral dermatomyositis syndrome	http://purl.obolibrary.org/obo/HP_0002743	Recurrent enteroviral infections		
http://purl.obolibrary.org/obo/HP_0003799	Marked delay in bone age	http://purl.obolibrary.org/obo/HP_0002750	Delayed skeletal maturation		
http://purl.obolibrary.org/obo/HP_0003423	Thoracolumbar kyphoscoliosis	http://purl.obolibrary.org/obo/HP_0005619	Thoracolumbar kyphosis		
http://purl.obolibrary.org/obo/HP_0003869	Humeral cortical thinning	http://purl.obolibrary.org/obo/HP_0010629	Abnormal morphology of the cortex of the humerus		
http://purl.obolibrary.org/obo/HP_0003088	Premature osteoarthritis	http://purl.obolibrary.org/obo/HP_0002758	Osteoarthritis		
http://purl.obolibrary.org/obo/HP_0002777	Tracheal stenosis	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		
http://purl.obolibrary.org/obo/HP_0002779	Tracheomalacia	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		
http://purl.obolibrary.org/obo/HP_0005957	Breathing dysregulation	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		
http://purl.obolibrary.org/obo/HP_0045060	Aplasia/hypoplasia involving bones of the extremities	http://purl.obolibrary.org/obo/HP_0009815	Aplasia/hypoplasia of the extremities		
http://purl.obolibrary.org/obo/HP_0001437	Abnormality of the musculature of the lower limbs	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		
http://purl.obolibrary.org/obo/HP_0001446	Abnormality of the musculature of the upper limbs	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		
http://purl.obolibrary.org/obo/HP_0001454	Abnormality of the upper arm	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		
http://purl.obolibrary.org/obo/HP_0003839	Abnormal upper limb epiphysis morphology	http://purl.obolibrary.org/obo/HP_0006505	Abnormal limb epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003068	Madelung-like forearm deformities	http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius		
http://purl.obolibrary.org/obo/HP_0003995	Abnormality of the radial head	http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius		
http://purl.obolibrary.org/obo/HP_0003366	Abnormal femoral neck/head morphology	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		
http://purl.obolibrary.org/obo/HP_0003001	Glomus jugular tumor	http://purl.obolibrary.org/obo/HP_0002864	Paraganglioma of head and neck		
http://purl.obolibrary.org/obo/HP_0002908	Conjugated hyperbilirubinemia	http://purl.obolibrary.org/obo/HP_0002904	Hyperbilirubinemia		
http://purl.obolibrary.org/obo/HP_0034822	Abnormal CSF ion concentration	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		
http://purl.obolibrary.org/obo/HP_0003059	Abnormality of the radioulnar joints	http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology		
http://purl.obolibrary.org/obo/HP_0003832	Abnormality of the tibial plateaux	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		
http://purl.obolibrary.org/obo/HP_0003848	Cupped metaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003850	Upper-limb metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0002821	Neuropathic arthropathy	http://purl.obolibrary.org/obo/HP_0003040	Arthropathy		
http://purl.obolibrary.org/obo/HP_0003836	Stippled calcification of the shoulder	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		
http://purl.obolibrary.org/obo/HP_0003910	Enlarged humeral metaphyses	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003895	Flattened humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003462	Elevated 8-dehydrocholesterol	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		
http://purl.obolibrary.org/obo/HP_0003465	Elevated 8(9)-cholestenol	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		
http://purl.obolibrary.org/obo/HP_0003456	Low urinary cyclic AMP response to PTH administration	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		
http://purl.obolibrary.org/obo/HP_0045014	Hypolipidemia	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		
http://purl.obolibrary.org/obo/HP_0003182	Shallow acetabular fossae	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		
http://purl.obolibrary.org/obo/HP_0003756	Skeletal myopathy	http://purl.obolibrary.org/obo/HP_0003198	Myopathy		
http://purl.obolibrary.org/obo/HP_0003079	Defective DNA repair after ultraviolet radiation damage	http://purl.obolibrary.org/obo/HP_0003254	Abnormality of DNA repair		
http://purl.obolibrary.org/obo/HP_0003213	Deficient excision of UV-induced pyrimidine dimers in DNA	http://purl.obolibrary.org/obo/HP_0003254	Abnormality of DNA repair		
http://purl.obolibrary.org/obo/HP_0002928	Decreased activity of the pyruvate dehydrogenase complex	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		
http://purl.obolibrary.org/obo/HP_0003232	Mitochondrial malic enzyme reduced	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		
http://purl.obolibrary.org/obo/HP_0003288	Mitochondrial propionyl-CoA carboxylase defect	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		
http://purl.obolibrary.org/obo/HP_0003514	Deficiency or absence of cytochrome b(-245)	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		
http://purl.obolibrary.org/obo/HP_0003309	Ovoid thoracolumbar vertebrae	http://purl.obolibrary.org/obo/HP_0003300	Ovoid vertebral bodies		
http://purl.obolibrary.org/obo/HP_0008479	Hypoplastic vertebral bodies	http://purl.obolibrary.org/obo/HP_0008417	Vertebral hypoplasia		
http://purl.obolibrary.org/obo/HP_0003318	Cervical spine hypermobility	http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine		
http://purl.obolibrary.org/obo/HP_0003329	Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		
http://purl.obolibrary.org/obo/HP_0002822	Hyperplasia of the femoral trochanters	http://purl.obolibrary.org/obo/HP_0003366	Abnormal femoral neck/head morphology		
http://purl.obolibrary.org/obo/HP_0003435	Cold-induced hand cramps	http://purl.obolibrary.org/obo/HP_0003449	Cold-induced muscle cramps		
http://purl.obolibrary.org/obo/HP_0002953	Vertebral compression fracture	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		
http://purl.obolibrary.org/obo/HP_0100790	Hernia	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		
http://purl.obolibrary.org/obo/HP_0003717	Minimal subcutaneous fat	http://purl.obolibrary.org/obo/HP_0003758	Reduced subcutaneous adipose tissue		
http://purl.obolibrary.org/obo/HP_0001054	Numerous nevi	http://purl.obolibrary.org/obo/HP_0003764	Nevus		
http://purl.obolibrary.org/obo/HP_0001074	Atypical nevi in non-sun exposed areas	http://purl.obolibrary.org/obo/HP_0003764	Nevus		
http://purl.obolibrary.org/obo/HP_0009141	Depletion of mitochondrial DNA in muscle tissue	http://purl.obolibrary.org/obo/HP_0030059	Mitochondrial depletion		
http://purl.obolibrary.org/obo/HP_0003833	Laterally deficient tibial plateaux	http://purl.obolibrary.org/obo/HP_0003832	Abnormality of the tibial plateaux		
http://purl.obolibrary.org/obo/HP_0003841	Fragmented upper limb epiphysis	http://purl.obolibrary.org/obo/HP_0100168	Fragmented epiphyses		
http://purl.obolibrary.org/obo/HP_0003842	Irregular epiphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0010582	Irregular epiphyses		
http://purl.obolibrary.org/obo/HP_0003843	Round epiphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0003839	Abnormal upper limb epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003844	Small epiphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0010585	Small epiphyses		
http://purl.obolibrary.org/obo/HP_0003846	Wide epiphyseal plates of the upper limbs	http://purl.obolibrary.org/obo/HP_0003839	Abnormal upper limb epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003904	Wide epiphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0010580	Enlarged epiphyses		
http://purl.obolibrary.org/obo/HP_0003896	Irregular humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003948	Irregular epiphyses of the elbow	http://purl.obolibrary.org/obo/HP_0003946	Abnormal elbow epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003899	Round humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003900	Small humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003950	Flared elbow metaphyses	http://purl.obolibrary.org/obo/HP_0003949	Abnormal elbow metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003913	Humeral metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003915	Lytic defects of the humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003916	Normal-density transverse humeral bands	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003853	Sclerosis with transverse striations in metaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0003854	Sclerosis of metaphyses of the upper limbs		
http://purl.obolibrary.org/obo/HP_0003952	Sclerotic foci of metaphyses of the elbow	http://purl.obolibrary.org/obo/HP_0003949	Abnormal elbow metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003928	Cortical thickening of humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003933	Sclerosis of humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003880	Sclerotic foci of the humerus	http://purl.obolibrary.org/obo/HP_0003881	Humeral sclerosis		
http://purl.obolibrary.org/obo/HP_0003888	Flattened humeral heads	http://purl.obolibrary.org/obo/HP_0003887	Abnormal humeral head morphology		
http://purl.obolibrary.org/obo/HP_0003890	Prominent deltoid tuberosities	http://purl.obolibrary.org/obo/HP_0003889	Abnormal deltoid tuberosity morphology		
http://purl.obolibrary.org/obo/HP_0003897	Irregular ossification of the humeral epiphyses	http://purl.obolibrary.org/obo/HP_0012791	Abnormal humeral ossification		
http://purl.obolibrary.org/obo/HP_0003898	Large humeral epiphyses	http://purl.obolibrary.org/obo/HP_0010580	Enlarged epiphyses		
http://purl.obolibrary.org/obo/HP_0003901	Stippled calcification of the humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003905	Abnormality of the humeral epiphyseal plate	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0003909	Cortical subperiosteal resorption of humeral metaphyses	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003912	Frayed humeral metaphyses	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003914	Irregular ossification of humeral metaphyses	http://purl.obolibrary.org/obo/HP_0012791	Abnormal humeral ossification		
http://purl.obolibrary.org/obo/HP_0003917	Pointed humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003918	Sclerotic humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003920	Sloping humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003922	Spurred humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003923	Square humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003924	Stippled calcification of humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003919	Sclerotic humeral metaphysis with longitudinal striations	http://purl.obolibrary.org/obo/HP_0003918	Sclerotic humeral metaphysis		
http://purl.obolibrary.org/obo/HP_0003921	Laterally sloping humeral metaphysis	http://purl.obolibrary.org/obo/HP_0003920	Sloping humeral metaphysis		
http://purl.obolibrary.org/obo/HP_0003889	Abnormal deltoid tuberosity morphology	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003929	Ground glass opacity of humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003930	Lytic defects of humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003931	Periosteal new bone of humeral diaphysis	http://purl.obolibrary.org/obo/HP_0030314	Periostosis		
http://purl.obolibrary.org/obo/HP_0003932	Sclerotic foci of humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003934	Slender humeral diaphysis	http://purl.obolibrary.org/obo/HP_0003926	Abnormal humeral diaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003944	Narrow joint spaces of the elbow	http://purl.obolibrary.org/obo/HP_0003943	Abnormality of the joint spaces of the elbow		
http://purl.obolibrary.org/obo/HP_0001241	Capitate-hamate fusion	http://purl.obolibrary.org/obo/HP_0009702	Carpal synostosis		
http://purl.obolibrary.org/obo/HP_0002359	Frequent falls	http://purl.obolibrary.org/obo/HP_0004302	Functional motor deficit		
http://purl.obolibrary.org/obo/HP_0003698	Difficulty standing	http://purl.obolibrary.org/obo/HP_0004302	Functional motor deficit		
http://purl.obolibrary.org/obo/HP_0003791	Deposits immunoreactive to beta-amyloid protein	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		
http://purl.obolibrary.org/obo/HP_0100295	Muscle fiber atrophy	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		
http://purl.obolibrary.org/obo/HP_0002747	Respiratory insufficiency due to muscle weakness	http://purl.obolibrary.org/obo/HP_0002093	Respiratory insufficiency		
http://purl.obolibrary.org/obo/HP_0003148	Elevated serum acid phosphatase	http://purl.obolibrary.org/obo/HP_0004356	Abnormality of lysosomal metabolism		
http://purl.obolibrary.org/obo/HP_0003264	Deficiency of N-acetylglucosamine-1-phosphotransferase	http://purl.obolibrary.org/obo/HP_0004356	Abnormality of lysosomal metabolism		
http://purl.obolibrary.org/obo/HP_0003206	Decreased activity of NADPH oxidase	http://purl.obolibrary.org/obo/HP_0004358	Abnormality of superoxide metabolism		
http://purl.obolibrary.org/obo/HP_0040157	Abnormal intermamillary distance	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		
http://purl.obolibrary.org/obo/HP_0006709	Aplasia/Hypoplasia of the nipples	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		
http://purl.obolibrary.org/obo/HP_0000383	Abnormal periauricular region morphology	http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology		
http://purl.obolibrary.org/obo/HP_0003321	Biconcave flattened vertebrae	http://purl.obolibrary.org/obo/HP_0000926	Platyspondyly		
http://purl.obolibrary.org/obo/HP_0003855	Spurred metaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003332	Absent primary metaphyseal spongiosa	http://purl.obolibrary.org/obo/HP_0005089	Abnormal metaphyseal trabeculation		
http://purl.obolibrary.org/obo/HP_0000417	Slender nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		
http://purl.obolibrary.org/obo/HP_0000433	Abnormal nasal mucosa morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		
http://purl.obolibrary.org/obo/HP_0000447	Pear-shaped nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		
http://purl.obolibrary.org/obo/HP_0003440	Horizontal sacrum	http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology		
http://purl.obolibrary.org/obo/HP_0000273	Facial grimacing	http://purl.obolibrary.org/obo/HP_0005324	Disturbance of facial expression		
http://purl.obolibrary.org/obo/HP_0002842	Recurrent Burkholderia cepacia infection	http://purl.obolibrary.org/obo/HP_5210079	Unusual Burkholderia cepacia infection		
http://purl.obolibrary.org/obo/HP_0002805	Accelerated bone age after puberty	http://purl.obolibrary.org/obo/HP_0005616	Accelerated skeletal maturation		
http://purl.obolibrary.org/obo/HP_0003867	Humeral cortical irregularity	http://purl.obolibrary.org/obo/HP_0010629	Abnormal morphology of the cortex of the humerus		
http://purl.obolibrary.org/obo/HP_0003089	Hamstring contractures	http://purl.obolibrary.org/obo/HP_0005750	Lower-limb joint contracture		
http://purl.obolibrary.org/obo/HP_0000891	Cervical ribs	http://purl.obolibrary.org/obo/HP_0005815	Supernumerary ribs		
http://purl.obolibrary.org/obo/HP_0001504	Metacarpal osteolysis	http://purl.obolibrary.org/obo/HP_0045039	Osteolysis involving bones of the upper limbs		
http://purl.obolibrary.org/obo/HP_0001501	6 metacarpals	http://purl.obolibrary.org/obo/HP_0005917	Supernumerary metacarpal bones		
http://purl.obolibrary.org/obo/HP_0001176	Large hands	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		
http://purl.obolibrary.org/obo/HP_0002663	Delayed epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0010656	Abnormal epiphyseal ossification		
http://purl.obolibrary.org/obo/HP_0003053	Epiphyseal deformities of tubular bones	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0002790	Neonatal breathing dysregulation	http://purl.obolibrary.org/obo/HP_0005957	Breathing dysregulation		
http://purl.obolibrary.org/obo/HP_0000466	Limited neck range of motion	http://purl.obolibrary.org/obo/HP_0005986	Limitation of neck motion		
http://purl.obolibrary.org/obo/HP_0001049	Absent dorsal skin creases over affected joints	http://purl.obolibrary.org/obo/HP_0006143	Abnormal finger flexion crease		
http://purl.obolibrary.org/obo/HP_0003881	Humeral sclerosis	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0000187	Broad alveolar ridges	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		
http://purl.obolibrary.org/obo/HP_0200161	Agenesis of mandibular incisor	http://purl.obolibrary.org/obo/HP_0006485	Agenesis of incisor		
http://purl.obolibrary.org/obo/HP_0040220	Abnormal size of the dental root	http://purl.obolibrary.org/obo/HP_0006486	Abnormal dental root morphology		
http://purl.obolibrary.org/obo/HP_0002834	Flared femoral metaphysis	http://purl.obolibrary.org/obo/HP_0030307	Flared lower limb metaphysis		
http://purl.obolibrary.org/obo/HP_0002089	Pulmonary hypoplasia	http://purl.obolibrary.org/obo/HP_0006703	Aplasia/Hypoplasia of the lungs		
http://purl.obolibrary.org/obo/HP_0001407	Hepatic cysts	http://purl.obolibrary.org/obo/HP_0006706	Cystic liver disease		
http://purl.obolibrary.org/obo/HP_0002672	Gastrointestinal carcinoma	http://purl.obolibrary.org/obo/HP_0006749	Malignant gastrointestinal tract tumors		
http://purl.obolibrary.org/obo/HP_0002398	Degeneration of anterior horn cells	http://purl.obolibrary.org/obo/HP_0007373	Motor neuron atrophy		
http://purl.obolibrary.org/obo/HP_0000933	Posterior fossa cyst at the fourth ventricle	http://purl.obolibrary.org/obo/HP_0007291	Posterior fossa cyst		
http://purl.obolibrary.org/obo/HP_0003426	First dorsal interossei muscle atrophy	http://purl.obolibrary.org/obo/HP_0007181	Interosseus muscle atrophy		
http://purl.obolibrary.org/obo/HP_0002529	Neuronal loss in central nervous system	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		
http://purl.obolibrary.org/obo/HP_0002340	Caudate atrophy	http://purl.obolibrary.org/obo/HP_0007374	Atrophy/Degeneration involving the caudate nucleus		
http://purl.obolibrary.org/obo/HP_0006749	Malignant gastrointestinal tract tumors	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		
http://purl.obolibrary.org/obo/HP_0000531	Corneal crystals	http://purl.obolibrary.org/obo/HP_0007759	Opacification of the corneal stroma		
http://purl.obolibrary.org/obo/HP_0000559	Corneal scarring	http://purl.obolibrary.org/obo/HP_0100699	Scarring		
http://purl.obolibrary.org/obo/HP_0001775	Tarsal osteovalgus	http://purl.obolibrary.org/obo/HP_5210430	Hindfoot deformity		
http://purl.obolibrary.org/obo/HP_0002929	Leydig cell insensitivity to gonadotropin	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		
http://purl.obolibrary.org/obo/HP_0002766	Relatively short spine	http://purl.obolibrary.org/obo/HP_0008518	Aplasia/Hypoplasia involving the vertebral column		
http://purl.obolibrary.org/obo/HP_0040016	Prominent coccyx	http://purl.obolibrary.org/obo/HP_0008519	Abnormal coccyx morphology		
http://purl.obolibrary.org/obo/HP_0040017	Protruding coccyx	http://purl.obolibrary.org/obo/HP_0008519	Abnormal coccyx morphology		
http://purl.obolibrary.org/obo/HP_0002831	Long coccyx	http://purl.obolibrary.org/obo/HP_0008519	Abnormal coccyx morphology		
http://purl.obolibrary.org/obo/HP_0009144	Supernumerary bones of the axial skeleton	http://purl.obolibrary.org/obo/HP_0009121	Abnormal axial skeleton morphology		
http://purl.obolibrary.org/obo/HP_0000291	Abnormality of facial adipose tissue	http://purl.obolibrary.org/obo/HP_0011799	Abnormality of facial soft tissue		
http://purl.obolibrary.org/obo/HP_0001001	Abnormality of subcutaneous fat tissue	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		
http://purl.obolibrary.org/obo/HP_0001469	Abnormal morphology of the pelvis musculature	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		
http://purl.obolibrary.org/obo/HP_0002509	Limb hypertonia	http://purl.obolibrary.org/obo/HP_0001276	Hypertonia		
http://purl.obolibrary.org/obo/HP_0010177	Osteolytic defects of the phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0001853	Bifid distal phalanx of toe	http://purl.obolibrary.org/obo/HP_0009136	Duplication involving bones of the feet		
http://purl.obolibrary.org/obo/HP_0002946	Supernumerary vertebrae	http://purl.obolibrary.org/obo/HP_0030304	Abnormal number of vertebrae		
http://purl.obolibrary.org/obo/HP_0001193	Ulnar deviation of the hand or of fingers of the hand	http://purl.obolibrary.org/obo/HP_0009484	Deviation of the hand or of fingers of the hand		
http://purl.obolibrary.org/obo/HP_0002859	Rhabdomyosarcoma	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		
http://purl.obolibrary.org/obo/HP_0000866	Euthyroid multinodular goiter	http://purl.obolibrary.org/obo/HP_0009798	Euthyroid goiter		
http://purl.obolibrary.org/obo/HP_0003858	Cortical diaphyseal irregularity of the upper limbs	http://purl.obolibrary.org/obo/HP_0009808	Anomaly of the upper limb diaphyses		
http://purl.obolibrary.org/obo/HP_0003859	Cortical diaphyseal thickening of the upper limbs	http://purl.obolibrary.org/obo/HP_0009808	Anomaly of the upper limb diaphyses		
http://purl.obolibrary.org/obo/HP_0003861	Broad diaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0009808	Anomaly of the upper limb diaphyses		
http://purl.obolibrary.org/obo/HP_0003851	Lytic defects in metaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003852	Normal density transverse bands in metaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003854	Sclerosis of metaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003907	Abnormal humeral metaphysis morphology	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0001301	Chronic sensorineural polyneuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0003489	Acute episodes of neuropathic symptoms	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0002220	Melanin pigment aggregation in hair shafts	http://purl.obolibrary.org/obo/HP_0009887	Abnormality of hair pigmentation		
http://purl.obolibrary.org/obo/HP_0002297	Red hair	http://purl.obolibrary.org/obo/HP_0009887	Abnormality of hair pigmentation		
http://purl.obolibrary.org/obo/HP_0005599	Hypopigmentation of hair	http://purl.obolibrary.org/obo/HP_0009887	Abnormality of hair pigmentation		
http://purl.obolibrary.org/obo/HP_0001842	Foot acroosteolysis	http://purl.obolibrary.org/obo/HP_0010177	Osteolytic defects of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010189	Osteolytic defects of the distal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0008067	Abnormally lax or hyperextensible skin	http://purl.obolibrary.org/obo/HP_0010647	Abnormal elasticity of skin		
http://purl.obolibrary.org/obo/HP_0100679	Lack of skin elasticity	http://purl.obolibrary.org/obo/HP_0010647	Abnormal elasticity of skin		
http://purl.obolibrary.org/obo/HP_0002212	Curly hair	http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture		
http://purl.obolibrary.org/obo/HP_0003779	Antegonial notching of mandible	http://purl.obolibrary.org/obo/HP_0010753	Midline defect of mandible		
http://purl.obolibrary.org/obo/HP_0001024	Skin dimple over apex of long bone angulation	http://purl.obolibrary.org/obo/HP_0010781	Skin dimple		
http://purl.obolibrary.org/obo/HP_0003140	T-wave inversion in the right precordial leads	http://purl.obolibrary.org/obo/HP_0010872	T-wave inversion		
http://purl.obolibrary.org/obo/HP_0011403	Abnormal umbilical cord blood vessel morphology	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		
http://purl.obolibrary.org/obo/HP_0001895	Normochromic anemia	http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production		
http://purl.obolibrary.org/obo/HP_0003224	Increased cellular sensitivity to UV light	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		
http://purl.obolibrary.org/obo/HP_0004356	Abnormality of lysosomal metabolism	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		
http://purl.obolibrary.org/obo/HP_0003214	Prolonged G2 phase of cell cycle	http://purl.obolibrary.org/obo/HP_0011018	Abnormality of the cell cycle		
http://purl.obolibrary.org/obo/HP_0001401	Intrahepatic biliary dysgenesis	http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology		
http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		
http://purl.obolibrary.org/obo/HP_0001008	Accumulation of melanosomes in melanocytes	http://purl.obolibrary.org/obo/HP_0011125	Abnormal dermal melanosome morphology		
http://purl.obolibrary.org/obo/HP_0002199	Hypocalcemic seizures	http://purl.obolibrary.org/obo/HP_0011145	Symptomatic seizures		
http://purl.obolibrary.org/obo/HP_0007394	Prominent superficial blood vessels	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		
http://purl.obolibrary.org/obo/HP_0002150	Hypercalciuria	http://purl.obolibrary.org/obo/HP_0011280	Abnormality of urine calcium concentration		
http://purl.obolibrary.org/obo/HP_0000497	Globe retraction and deviation on abduction	http://purl.obolibrary.org/obo/HP_0011347	Abnormality of ocular abduction		
http://purl.obolibrary.org/obo/HP_0001005	Dermatological manifestations of systemic disorders	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		
http://purl.obolibrary.org/obo/HP_0007495	Prematurely aged appearance	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		
http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		
http://purl.obolibrary.org/obo/HP_0002298	Absent hair	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		
http://purl.obolibrary.org/obo/HP_0011443	Abnormality of coordination	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		
http://purl.obolibrary.org/obo/HP_0002038	Protein avoidance	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		
http://purl.obolibrary.org/obo/HP_0003466	Paradoxical increased cortisol secretion on dexamethasone suppression test	http://purl.obolibrary.org/obo/HP_0011731	Abnormality of circulating cortisol level		
http://purl.obolibrary.org/obo/HP_0000849	Adrenocortical abnormality	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		
http://purl.obolibrary.org/obo/HP_0002717	Adrenal overactivity	http://purl.obolibrary.org/obo/HP_0011733	Abnormality of adrenal physiology		
http://purl.obolibrary.org/obo/HP_0002898	Embryonal neoplasm	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		
http://purl.obolibrary.org/obo/HP_0000282	Facial edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		
http://purl.obolibrary.org/obo/HP_0003559	Muscle hyperirritability	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		
http://purl.obolibrary.org/obo/HP_0003800	Muscle abnormality related to mitochondrial dysfunction	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		
http://purl.obolibrary.org/obo/HP_0003808	Abnormal muscle tone	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		
http://purl.obolibrary.org/obo/HP_0004302	Functional motor deficit	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		
http://purl.obolibrary.org/obo/HP_0040291	Skeletal muscle steatosis	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		
http://purl.obolibrary.org/obo/HP_0003199	Decreased muscle mass	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		
http://purl.obolibrary.org/obo/HP_0003716	Generalized muscular appearance from birth	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		
http://purl.obolibrary.org/obo/HP_0000943	Dysostosis multiplex	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		
http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology	http://purl.obolibrary.org/obo/HP_0011843	Abnormal musculoskeletal physiology		
http://purl.obolibrary.org/obo/HP_0003784	Type 1 collagen overmodification	http://purl.obolibrary.org/obo/HP_0011862	Abnormal bone collagen fibril morphology		
http://purl.obolibrary.org/obo/HP_0003277	Constricted iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		
http://purl.obolibrary.org/obo/HP_0003249	Genital ulcers	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		
http://purl.obolibrary.org/obo/HP_0003252	Anteriorly displaced genitalia	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		
http://purl.obolibrary.org/obo/HP_0005607	Abnormal tracheobronchial morphology	http://purl.obolibrary.org/obo/HP_0012252	Abnormal respiratory system morphology		
http://purl.obolibrary.org/obo/HP_0004329	Abnormal posterior eye segment morphology	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		
http://purl.obolibrary.org/obo/HP_0008056	Aplasia/Hypoplasia affecting the eye	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		
http://purl.obolibrary.org/obo/HP_0001984	Intolerance to protein	http://purl.obolibrary.org/obo/HP_0012537	Food intolerance		
http://purl.obolibrary.org/obo/HP_0000223	Abnormality of taste sensation	http://purl.obolibrary.org/obo/HP_0030810	Abnormal tongue physiology		
http://purl.obolibrary.org/obo/HP_0002483	Bulbar signs	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		
http://purl.obolibrary.org/obo/HP_0002589	Gastrointestinal atresia	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		
http://purl.obolibrary.org/obo/HP_0004296	Abnormal gastrointestinal vascular morphology	http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology		
http://purl.obolibrary.org/obo/HP_0002374	Diminished movement	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		
http://purl.obolibrary.org/obo/HP_0002457	Abnormal head movements	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		
http://purl.obolibrary.org/obo/HP_0002293	Alopecia of scalp	http://purl.obolibrary.org/obo/HP_0001596	Alopecia		
http://purl.obolibrary.org/obo/HP_0010179	Toe symphalangism	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0100265	Synostosis of metacarpals/metatarsals	http://purl.obolibrary.org/obo/HP_0100240	Synostosis of joints		
http://purl.obolibrary.org/obo/HP_0002310	Orofacial dyskinesia	http://purl.obolibrary.org/obo/HP_0100660	Dyskinesia		
http://purl.obolibrary.org/obo/HP_0002752	Sparse bone trabeculae	http://purl.obolibrary.org/obo/HP_0100671	Abnormal trabecular bone morphology		
http://purl.obolibrary.org/obo/HP_0002943	Thoracic scoliosis	http://purl.obolibrary.org/obo/HP_0002650	Scoliosis		
http://purl.obolibrary.org/obo/HP_0100823	Genital hernia	http://purl.obolibrary.org/obo/HP_0100790	Hernia		
http://purl.obolibrary.org/obo/HP_0000584	Punctate corneal epithelial erosions	http://purl.obolibrary.org/obo/HP_0200020	Corneal erosion		
http://purl.obolibrary.org/obo/HP_0003616	Premature separation of centromeric heterochromatin	http://purl.obolibrary.org/obo/HP_0200024	Premature chromatid separation		
http://purl.obolibrary.org/obo/HP_0001026	Penetrating foot ulcers	http://purl.obolibrary.org/obo/HP_0200042	Skin ulcer		
http://purl.obolibrary.org/obo/UBERON_0036267	vulval vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		
http://purl.obolibrary.org/obo/UBERON_0035546	uveal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		
http://purl.obolibrary.org/obo/UBERON_0035662	parotid vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		
http://purl.obolibrary.org/obo/UBERON_0035237	branch of internal carotid artery	http://purl.obolibrary.org/obo/UBERON_0005396	carotid artery segment		
http://purl.obolibrary.org/obo/HP_0001607	Subglottic stenosis	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		
http://purl.obolibrary.org/obo/HP_0034723	Elevated CSF hydroxyproline concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		
http://purl.obolibrary.org/obo/HP_0003863	Angulated humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003866	Coarse humeral trabeculae	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003870	Crumpled humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003871	Deformed humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003874	Humerus varus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003876	Osteoporotic humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003877	Oval transradiancy of humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003878	Periosteal new bone of humerus	http://purl.obolibrary.org/obo/HP_0030314	Periostosis		
http://purl.obolibrary.org/obo/HP_0003879	Humeral pseudarthrosis	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003883	Tapered humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003884	Triangular humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003885	Undermodeled humerus	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0003886	Wide humerus	http://purl.obolibrary.org/obo/HP_0005622	Broad long bones		
http://purl.obolibrary.org/obo/HP_0003887	Abnormal humeral head morphology	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_5200238	Vowel expressive impediment	http://purl.obolibrary.org/obo/HP_5200237	Pronunciation difficulties		
http://purl.obolibrary.org/obo/HP_5200239	Consonant expressive impediment	http://purl.obolibrary.org/obo/HP_5200237	Pronunciation difficulties		
http://purl.obolibrary.org/obo/HP_5200362	Short NREM sleep	http://purl.obolibrary.org/obo/HP_5200298	Abnormal sleep architecture		
http://purl.obolibrary.org/obo/HP_5200363	Prolonged NREM sleep	http://purl.obolibrary.org/obo/HP_5200298	Abnormal sleep architecture		
http://purl.obolibrary.org/obo/HP_0001225	Wrist swelling	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		
http://purl.obolibrary.org/obo/HP_0003020	Enlargement of the wrists	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		
http://purl.obolibrary.org/obo/HP_0003049	Ulnar deviation of the wrist	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		
http://purl.obolibrary.org/obo/CHEBI_18274	2'-deoxyribonucleoside	http://purl.obolibrary.org/obo/CHEBI_47018	monohydroxytetrahydrofuran		
http://purl.obolibrary.org/obo/CHEBI_81568	Luteinizing hormone	http://purl.obolibrary.org/obo/CHEBI_17089	glycoprotein		
http://purl.obolibrary.org/obo/CHEBI_37624	L-glucose	http://purl.obolibrary.org/obo/CHEBI_17234	glucose		
http://purl.obolibrary.org/obo/CHEBI_37661	glucopyranose	http://purl.obolibrary.org/obo/CHEBI_17234	glucose		
http://purl.obolibrary.org/obo/CHEBI_38856	halophenol	http://purl.obolibrary.org/obo/CHEBI_33853	phenols		
http://purl.obolibrary.org/obo/CHEBI_24500	heparan	http://purl.obolibrary.org/obo/CHEBI_18085	glycosaminoglycan		
http://purl.obolibrary.org/obo/CHEBI_37404	elemental copper	http://purl.obolibrary.org/obo/CHEBI_23377	copper molecular entity		
http://purl.obolibrary.org/obo/CHEBI_35724	carbohydrate sulfate	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		
http://purl.obolibrary.org/obo/CHEBI_46883	carboxy group	http://purl.obolibrary.org/obo/CHEBI_33249	organyl group		
http://purl.obolibrary.org/obo/CHEBI_36164	amino dicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_32613	isoleucinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_32661	asparaginium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_23636	deoxyribonucleoside	http://purl.obolibrary.org/obo/CHEBI_33838	nucleoside		
http://purl.obolibrary.org/obo/CHEBI_18361	diphosphate(4-)	http://purl.obolibrary.org/obo/CHEBI_35782	diphosphate ion		
http://purl.obolibrary.org/obo/CHEBI_138152	serum amyloid A	http://purl.obolibrary.org/obo/CHEBI_36080	protein		
http://purl.obolibrary.org/obo/CHEBI_49095	beta-amino-acid anion	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_27150	trisaccharide	http://purl.obolibrary.org/obo/CHEBI_50699	oligosaccharide		
http://purl.obolibrary.org/obo/CHEBI_22483	amino oligosaccharide	http://purl.obolibrary.org/obo/CHEBI_63563	oligosaccharide derivative		
http://purl.obolibrary.org/obo/CHEBI_43176	hydroxy group	http://purl.obolibrary.org/obo/CHEBI_33246	inorganic group		
http://purl.obolibrary.org/obo/CHEBI_29108	calcium(2+)	http://purl.obolibrary.org/obo/CHEBI_60240	divalent metal cation		
http://purl.obolibrary.org/obo/HP_0000315	Abnormality of the orbital region	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		
http://purl.obolibrary.org/obo/HP_0011799	Abnormality of facial soft tissue	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		
http://purl.obolibrary.org/obo/HP_0003778	Short mandibular rami	http://purl.obolibrary.org/obo/HP_3000003	Abnormal mandibular ramus morphology		
http://purl.obolibrary.org/obo/HP_0001488	Bilateral ptosis	http://purl.obolibrary.org/obo/HP_0000508	Ptosis		
http://purl.obolibrary.org/obo/HP_0000548	Cone/cone-rod dystrophy	http://purl.obolibrary.org/obo/HP_0000556	Retinal dystrophy		
http://purl.obolibrary.org/obo/HP_0001045	Vitiligo	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0003323	Progressive muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		
http://purl.obolibrary.org/obo/HP_0003704	Scapuloperoneal weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		
http://purl.obolibrary.org/obo/HP_0040312	Temporomandibular arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		
http://purl.obolibrary.org/obo/HP_0003095	Septic arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		
http://purl.obolibrary.org/obo/HP_0001525	Severe failure to thrive	http://purl.obolibrary.org/obo/HP_0001508	Failure to thrive		
http://purl.obolibrary.org/obo/HP_0001531	Failure to thrive in infancy	http://purl.obolibrary.org/obo/HP_0001508	Failure to thrive		
http://purl.obolibrary.org/obo/HP_0001615	Hoarse cry	http://purl.obolibrary.org/obo/HP_0001609	Hoarse voice		
http://purl.obolibrary.org/obo/HP_0001986	Hypertonic dehydration	http://purl.obolibrary.org/obo/HP_0001944	Dehydration		
http://purl.obolibrary.org/obo/HP_0002641	Peripheral thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		
http://purl.obolibrary.org/obo/HP_0002068	Neuromuscular dysphagia	http://purl.obolibrary.org/obo/HP_0002015	Dysphagia		
http://purl.obolibrary.org/obo/HP_0002207	Diffuse reticular or finely nodular infiltrations	http://purl.obolibrary.org/obo/HP_0002113	Pulmonary infiltrates		
http://purl.obolibrary.org/obo/HP_0002632	Low-to-normal blood pressure	http://purl.obolibrary.org/obo/HP_0002615	Hypotension		
http://purl.obolibrary.org/obo/HP_0002944	Thoracolumbar scoliosis	http://purl.obolibrary.org/obo/HP_0002650	Scoliosis		
http://purl.obolibrary.org/obo/HP_0003561	Birth length less than 3rd percentile	http://purl.obolibrary.org/obo/HP_0004322	Short stature		
http://purl.obolibrary.org/obo/UBERON_0035350	branch of middle cerebral artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0035548	colic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/CHEBI_28115	methylcobalamin	http://purl.obolibrary.org/obo/CHEBI_23334	cobalamins		
http://purl.obolibrary.org/obo/HP_0031911	Abnormal fifth cranial nerve physiology	http://purl.obolibrary.org/obo/HP_0031910	Abnormal cranial nerve physiology		
http://purl.obolibrary.org/obo/HP_0006824	Cranial nerve paralysis	http://purl.obolibrary.org/obo/HP_0031910	Abnormal cranial nerve physiology		
http://purl.obolibrary.org/obo/CHEBI_46701	pyrrolidinemonocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_46767	pyrrolidinecarboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_36757	farnesane sesquiterpenoid	http://purl.obolibrary.org/obo/CHEBI_26658	sesquiterpenoid		
http://purl.obolibrary.org/obo/CHEBI_32964	ornithinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_32612	isoleucinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_38180	polycyclic heteroarene	http://purl.obolibrary.org/obo/CHEBI_33833	heteroarene		
http://purl.obolibrary.org/obo/CHEBI_33570	benzenediols	http://purl.obolibrary.org/obo/CHEBI_33853	phenols		
http://purl.obolibrary.org/obo/CHEBI_23690	dicarboxylic acid amide	http://purl.obolibrary.org/obo/CHEBI_37622	carboxamide		
http://purl.obolibrary.org/obo/CHEBI_80332	C-peptide	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		
http://purl.obolibrary.org/obo/CHEBI_24606	homoarginine	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		
http://purl.obolibrary.org/obo/CHEBI_25810	oxopurine	http://purl.obolibrary.org/obo/CHEBI_26401	purines		
http://purl.obolibrary.org/obo/CHEBI_33743	manganese group molecular entity	http://purl.obolibrary.org/obo/CHEBI_33676	d-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33744	iron group molecular entity	http://purl.obolibrary.org/obo/CHEBI_33676	d-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33745	copper group molecular entity	http://purl.obolibrary.org/obo/CHEBI_33676	d-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_24384	glycogens	http://purl.obolibrary.org/obo/CHEBI_37163	glucan		
http://purl.obolibrary.org/obo/CHEBI_21672	N-amidino-amino acid	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		
http://purl.obolibrary.org/obo/CHEBI_30839	orotate	http://purl.obolibrary.org/obo/CHEBI_38316	pyrimidinecarboxylate anion		
http://purl.obolibrary.org/obo/CHEBI_33552	sulfonic acid derivative	http://purl.obolibrary.org/obo/CHEBI_33424	sulfur oxoacid derivative		
http://purl.obolibrary.org/obo/CHEBI_33340	zinc group element atom	http://purl.obolibrary.org/obo/CHEBI_33561	d-block element atom		
http://purl.obolibrary.org/obo/CHEBI_33608	hydrogen molecular entity	http://purl.obolibrary.org/obo/CHEBI_33674	s-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33673	zinc group molecular entity	http://purl.obolibrary.org/obo/CHEBI_33676	d-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33778	galactonates	http://purl.obolibrary.org/obo/CHEBI_33760	hexonate		
http://purl.obolibrary.org/obo/CHEBI_39128	magnesium ion	http://purl.obolibrary.org/obo/CHEBI_33973	elemental magnesium		
http://purl.obolibrary.org/obo/HP_0004344	Abnormality of cerebrosidase metabolism	http://purl.obolibrary.org/obo/HP_0004343	Abnormal glycosphingolipid metabolism		
http://purl.obolibrary.org/obo/HP_0012145	Abnormality of multiple cell lineages in the bone marrow	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		
http://purl.obolibrary.org/obo/HP_0030462	Abnormal amplitude of flash visual evoked potentials	http://purl.obolibrary.org/obo/HP_0007928	Abnormal flash visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0200006	Slanting of the palpebral fissure	http://purl.obolibrary.org/obo/HP_0008050	Abnormality of the palpebral fissures		
http://purl.obolibrary.org/obo/HP_5200237	Pronunciation difficulties	http://purl.obolibrary.org/obo/HP_0009088	Speech articulation difficulties		
http://purl.obolibrary.org/obo/HP_0040022	Clinodactyly of the 2nd finger	http://purl.obolibrary.org/obo/HP_0040019	Finger clinodactyly		
http://purl.obolibrary.org/obo/HP_0010246	Absent epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010604	Cyst of the eyelid	http://purl.obolibrary.org/obo/HP_0200040	Epidermoid cyst		
http://purl.obolibrary.org/obo/HP_0100728	Germ cell neoplasia	http://purl.obolibrary.org/obo/HP_0010785	Gonadal neoplasm		
http://purl.obolibrary.org/obo/HP_5200240	Delayed spoken language comprehension	http://purl.obolibrary.org/obo/HP_0010863	Receptive language delay		
http://purl.obolibrary.org/obo/HP_0040159	Abnormal spaced incisors	http://purl.obolibrary.org/obo/HP_0011062	Misalignment of incisors		
http://purl.obolibrary.org/obo/HP_0003142	Excessive purine production	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		
http://purl.obolibrary.org/obo/HP_0003258	Glyoxalase deficiency	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		
http://purl.obolibrary.org/obo/HP_0004358	Abnormality of superoxide metabolism	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		
http://purl.obolibrary.org/obo/HP_0040277	Neoplasm of the pituitary gland	http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system		
http://purl.obolibrary.org/obo/HP_0100835	Benign neoplasm of the central nervous system	http://purl.obolibrary.org/obo/HP_0100006	Neoplasm of the central nervous system		
http://purl.obolibrary.org/obo/HP_0100263	Distal symphalangism	http://purl.obolibrary.org/obo/HP_0100262	Synostosis involving digits		
http://purl.obolibrary.org/obo/HP_0000650	Abnormal amplitude of pattern reversal visual evoked potentials	http://purl.obolibrary.org/obo/HP_0100289	Abnormality of pattern reversal visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030437	Anal canal neoplasm	http://purl.obolibrary.org/obo/HP_0032186	Anal neoplasm		
http://purl.obolibrary.org/obo/HP_0100273	Neoplasm of the colon	http://purl.obolibrary.org/obo/HP_0100834	Neoplasm of the large intestine		
http://purl.obolibrary.org/obo/HP_0012031	Lipomatous tumor	http://purl.obolibrary.org/obo/HP_0200013	Neoplasm of fatty tissue		
http://purl.obolibrary.org/obo/UBERON_0035313	posterior wall of laryngopharynx	http://purl.obolibrary.org/obo/UBERON_0000328	gut wall		
http://purl.obolibrary.org/obo/UBERON_0035383	lateral wall of nasopharynx	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0035401	posterior wall of nasopharynx	http://purl.obolibrary.org/obo/UBERON_0000328	gut wall		
http://purl.obolibrary.org/obo/UBERON_0035322	right common iliac artery	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0035529	left common iliac artery	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0002495	long bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		
http://purl.obolibrary.org/obo/UBERON_0035004	preputial swelling	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0036186	fibroelastic connective tissue	http://purl.obolibrary.org/obo/UBERON_0011824	fibrous connective tissue		
http://purl.obolibrary.org/obo/UBERON_0035020	left vagus X nerve trunk	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0035021	right vagus X nerve trunk	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0035104	raphe of penis	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		
http://purl.obolibrary.org/obo/UBERON_0036290	myocardium of anterior wall of left ventricle	http://purl.obolibrary.org/obo/UBERON_0006566	left ventricle myocardium		
http://purl.obolibrary.org/obo/UBERON_0036291	myocardium of anterior wall of right ventricle	http://purl.obolibrary.org/obo/UBERON_0006567	right ventricle myocardium		
http://purl.obolibrary.org/obo/UBERON_0035927	sulcus of parietal lobe	http://purl.obolibrary.org/obo/UBERON_0013118	sulcus of brain		
http://purl.obolibrary.org/obo/HP_0000025	Functional abnormality of male internal genitalia	http://purl.obolibrary.org/obo/HP_0012874	Abnormal male reproductive system physiology		
http://purl.obolibrary.org/obo/HP_0001341	Olfactory lobe agenesis	http://purl.obolibrary.org/obo/HP_0025057	Abnormal olfactory lobe morphology		
http://purl.obolibrary.org/obo/HP_0033708	Anti-3-hydroxy- 3-methylglutaryl-coA reductase antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		
http://purl.obolibrary.org/obo/HP_0003427	Thenar muscle weakness	http://purl.obolibrary.org/obo/HP_0030237	Hand muscle weakness		
http://purl.obolibrary.org/obo/HP_0040294	Duplicated tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		
http://purl.obolibrary.org/obo/HP_0000199	Tongue nodules	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		
http://purl.obolibrary.org/obo/HP_0000182	Movement abnormality of the tongue	http://purl.obolibrary.org/obo/HP_0030810	Abnormal tongue physiology		
http://purl.obolibrary.org/obo/HP_0003954	Angulated forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/UBERON_0035471	posterior surface of kidney	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		
http://purl.obolibrary.org/obo/HP_0040006	Mortality/Aging	http://purl.obolibrary.org/obo/HP_0031797	Clinical course		
http://purl.obolibrary.org/obo/HP_0003679	Pace of progression	http://purl.obolibrary.org/obo/HP_0031797	Clinical course		
http://purl.obolibrary.org/obo/CHEBI_35313	hexoside	http://purl.obolibrary.org/obo/CHEBI_24400	glycoside		
http://purl.obolibrary.org/obo/CHEBI_28694	copper atom	http://purl.obolibrary.org/obo/CHEBI_88184	metal allergen		
http://purl.obolibrary.org/obo/CHEBI_7044	myoglobin	http://purl.obolibrary.org/obo/CHEBI_5386	globin		
http://purl.obolibrary.org/obo/HP_0001033	Facial flushing after alcohol intake	http://purl.obolibrary.org/obo/HP_0031284	Flushing		
http://purl.obolibrary.org/obo/HP_0100755	Abnormality of salivation	http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology		
http://purl.obolibrary.org/obo/HP_0031212	Abnormal circulating progesterone level	http://purl.obolibrary.org/obo/HP_0033799	Abnormal circulating sex hormone concentration		
http://purl.obolibrary.org/obo/HP_0000721	Lack of spontaneous play	http://purl.obolibrary.org/obo/HP_5200104	Abnormal play		
http://purl.obolibrary.org/obo/HP_4000120	Triggered by nickel	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		
http://purl.obolibrary.org/obo/HP_0040171	Decreased serum testosterone concentration	http://purl.obolibrary.org/obo/HP_0030349	Decreased circulating androgen concentration		
http://purl.obolibrary.org/obo/HP_0030478	Abnormal amplitude of dark-adapted bright flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030470	Abnormal dark-adapted bright flash electroretinogram		
http://purl.obolibrary.org/obo/HP_0040253	Increased size of the clitoris	http://purl.obolibrary.org/obo/HP_0040252	Abnormal size of the clitoris		
http://purl.obolibrary.org/obo/HP_0045085	Atrophy of masseter muscle	http://purl.obolibrary.org/obo/HP_3000005	Abnormality of masseter muscle		
http://purl.obolibrary.org/obo/NBO_0000120	physical aggression behavior	http://purl.obolibrary.org/obo/NBO_0000741	aggressive behavior by means		
http://purl.obolibrary.org/obo/HP_0005986	Limitation of neck motion	http://purl.obolibrary.org/obo/HP_0025669	Abnormal neck physiology		
http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		
http://purl.obolibrary.org/obo/HP_0031939	Conus terminalis arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0031938	Abnormal conus terminalis morphology		
http://purl.obolibrary.org/obo/UBERON_0036288	anterior wall of left ventricle	http://purl.obolibrary.org/obo/UBERON_0036285	wall of left ventricle		
http://purl.obolibrary.org/obo/HP_4000060	Abnormal pulmonary alveolar system development	http://purl.obolibrary.org/obo/HP_0033137	Abnormal pulmonary alveolar system morphology		
http://purl.obolibrary.org/obo/HP_0006703	Aplasia/Hypoplasia of the lungs	http://purl.obolibrary.org/obo/HP_4000059	Abnormal lung development		
http://purl.obolibrary.org/obo/HP_0040287	Axial muscle atrophy	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		
http://purl.obolibrary.org/obo/HP_0031214	Decreased circulating dehydroepiandrosterone concentration	http://purl.obolibrary.org/obo/HP_0500022	Abnormal circulating dehydroepiandrosterone concentration		
http://purl.obolibrary.org/obo/HP_0040008	Aplasia of facial bones	http://purl.obolibrary.org/obo/HP_0034261	Aplasia/Hypoplasia of facial bones		
http://purl.obolibrary.org/obo/HP_0002692	Hypoplastic facial bones	http://purl.obolibrary.org/obo/HP_0034261	Aplasia/Hypoplasia of facial bones		
http://purl.obolibrary.org/obo/HP_0001612	Weak cry	http://purl.obolibrary.org/obo/HP_0025429	Abnormal cry		
http://purl.obolibrary.org/obo/HP_4000012	Necrotizing ileitis	http://purl.obolibrary.org/obo/HP_0032564	Ileitis		
http://purl.obolibrary.org/obo/HP_0020066	Pathological inclusion body by subcellular location	http://purl.obolibrary.org/obo/HP_6001025	Pathological inclusion body		
http://purl.obolibrary.org/obo/HP_0020067	Pathological inclusion body by anatomical location	http://purl.obolibrary.org/obo/HP_6001025	Pathological inclusion body		
http://purl.obolibrary.org/obo/HP_0045036	Abnormal urinary copper concentration	http://purl.obolibrary.org/obo/HP_0025640	Abnormal urinary mineral level		
http://purl.obolibrary.org/obo/HP_0034245	Fetal head anomaly	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		
http://purl.obolibrary.org/obo/HP_0034990	Shoulder abduction contracture	http://purl.obolibrary.org/obo/HP_0034665	Shoulder contracture		
http://purl.obolibrary.org/obo/HP_0001785	Ankle swelling	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		
http://purl.obolibrary.org/obo/HP_0003029	Enlargement of the ankles	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		
http://purl.obolibrary.org/obo/CHEBI_75772	Saccharomyces cerevisiae metabolite	http://purl.obolibrary.org/obo/CHEBI_76946	fungal metabolite		Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (<em>Saccharomyces cerevisiae </em>).
http://purl.obolibrary.org/obo/CHEBI_76871	EC 2.1.1.* (methyltransferases) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76655	EC 2.1.* (C1-transferase) inhibitor		An EC 2.1.* (C<small><sub>1</sub></small>-transferase) inhibitor that interferes with the action of any methyltransferase (EC 2.1.1.*).
http://purl.obolibrary.org/obo/CHEBI_85234	human blood serum metabolite	http://purl.obolibrary.org/obo/CHEBI_77746	human metabolite		Any metabolite (endogenous or exogenous) found in human blood serum samples.
http://purl.obolibrary.org/obo/CHEBI_11955	4-amino-3-hydroxybutanoate	http://purl.obolibrary.org/obo/CHEBI_71666	gamma-amino acid anion		The conjugate base of γ-amino-β-hydroxybutyric acid arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_15901	5,6-dihydrouracil	http://purl.obolibrary.org/obo/CHEBI_38337	pyrimidone		A pyrimidine obtained by formal addition of hydrogen across the 5,6-position of uracil.
http://purl.obolibrary.org/obo/CHEBI_16010	5-oxoproline	http://purl.obolibrary.org/obo/CHEBI_25801	oxoproline		An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.
http://purl.obolibrary.org/obo/CHEBI_16080	gamma-amino-beta-hydroxybutyric acid	http://purl.obolibrary.org/obo/CHEBI_35969	3-hydroxy monocarboxylic acid		A γ-amino acid comprising 4-aminobutyric acid having a 2-hydroxy substituent.
http://purl.obolibrary.org/obo/CHEBI_16135	isobutyric acid	http://purl.obolibrary.org/obo/CHEBI_140601	fatty acid 4:0		A branched fatty acid comprising propanoic acid carrying a methyl branch at C-2.
http://purl.obolibrary.org/obo/CHEBI_16924	5-oxo-D-proline	http://purl.obolibrary.org/obo/CHEBI_84185	D-proline derivative		The <small>D</small>-enantiomer of 5-oxoproline.
http://purl.obolibrary.org/obo/CHEBI_17168	5alpha-cholest-7-en-3beta-ol	http://purl.obolibrary.org/obo/CHEBI_138130	Delta(7)-sterol		A cholestanoid that is (5α)-cholest-7-ene substituted by a β-hydroxy group at position 3.
http://purl.obolibrary.org/obo/CHEBI_17549	5-aminolevulinic acid	http://purl.obolibrary.org/obo/CHEBI_35931	delta-amino acid		The simplest δ-amino acid in which the hydrogens at the γ position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
http://purl.obolibrary.org/obo/CHEBI_17865	4-methyl-2-oxopentanoate	http://purl.obolibrary.org/obo/CHEBI_191201	branched-chain keto acid anion		A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
http://purl.obolibrary.org/obo/CHEBI_18101	4-hydroxyphenylacetic acid	http://purl.obolibrary.org/obo/CHEBI_33853	phenols		A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.
http://purl.obolibrary.org/obo/CHEBI_18183	5-oxo-L-proline	http://purl.obolibrary.org/obo/CHEBI_84186	L-proline derivative		An optically active form of 5-oxoproline having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_18240	4-hydroxy-L-proline	http://purl.obolibrary.org/obo/CHEBI_84186	L-proline derivative		The <small>L</small>-stereoisomer of 4-hydroxyproline.
http://purl.obolibrary.org/obo/CHEBI_22260	adenosines	http://purl.obolibrary.org/obo/CHEBI_26399	purine ribonucleoside		Any purine ribonucleoside that is a derivative of adenosine.
http://purl.obolibrary.org/obo/CHEBI_22478	amino alcohol	http://purl.obolibrary.org/obo/CHEBI_30879	alcohol		An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_30566	gamma-aminobutyrate	http://purl.obolibrary.org/obo/CHEBI_71666	gamma-amino acid anion		An γ-amino acid anion resulting from the deprotonation of the carboxy group of γ-aminobutyric acid.
http://purl.obolibrary.org/obo/CHEBI_38867	anaesthetic	http://purl.obolibrary.org/obo/CHEBI_23888	drug		Substance which produces loss of feeling or sensation.
http://purl.obolibrary.org/obo/CHEBI_39150	4-oxopentanoate	http://purl.obolibrary.org/obo/CHEBI_25798	oxopentanoates		A member of the class of oxopentanoates that is the conjugate base of 4-oxopentanoic acid.
http://purl.obolibrary.org/obo/CHEBI_50047	organic amino compound	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.
http://purl.obolibrary.org/obo/CHEBI_57630	gamma-amino-beta-hydroxybutyric acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of γ-amino-β-hydroxybutyric acid having an anionic carboxy group and a protonated amino group.
http://purl.obolibrary.org/obo/CHEBI_59558	medium-chain fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		A fatty acid anion resulting from the deprotonation of the carboxylic acid moiety of a medium-chain fatty acid.
http://purl.obolibrary.org/obo/CHEBI_67016	tetrahydrofolate	http://purl.obolibrary.org/obo/CHEBI_67011	folates		A folate obtained by deprotonation of any tetrahydrofolic acid.
http://purl.obolibrary.org/obo/CHEBI_76206	xenobiotic metabolite	http://purl.obolibrary.org/obo/CHEBI_25212	metabolite		Any metabolite produced by metabolism of a xenobiotic compound.
http://purl.obolibrary.org/obo/CHEBI_132939	ethylmalonate(2-)	http://purl.obolibrary.org/obo/CHEBI_132938	ethylmalonate		A dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxylic acid groups of ethylmalonic acid.
http://purl.obolibrary.org/obo/CHEBI_132952	oxalate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of oxalic acid.
http://purl.obolibrary.org/obo/CHEBI_132953	suberate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of suberic acid.
http://purl.obolibrary.org/obo/CHEBI_132954	sebacate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of sebacic acid.
http://purl.obolibrary.org/obo/CHEBI_132961	methylsuccinate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 3-methylsuccinic acid.
http://purl.obolibrary.org/obo/CHEBI_132966	hippurates	http://purl.obolibrary.org/obo/CHEBI_57670	N-acylglycinate		An <em>N</em>-acylglycinate obtained by deprotonation of the carboxy group of hippuric acid (<em>N</em>-benzoylglycine) and its derivatives.
http://purl.obolibrary.org/obo/CHEBI_132970	5-ammoniolevulinic acid	http://purl.obolibrary.org/obo/CHEBI_65296	primary ammonium ion		A primary ammonium ion obtained by protonation of the amino group of 5-aminolevulinic acid.
http://purl.obolibrary.org/obo/CHEBI_133291	saturated dicarboxylic acid dianion(2-)	http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion		A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid that contains no carbon-carbon double bonds.
http://purl.obolibrary.org/obo/CHEBI_133294	oxo dicarboxylic acid dianion	http://purl.obolibrary.org/obo/CHEBI_35903	oxo carboxylic acid anion		A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of any oxo dicarboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_133580	N-hexanoylglycinate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion that is the conjugate base of <em>N</em>-hexanoylglycine, obtained by deprotonation of the carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_133608	1-methylhistidine zwitterion	http://purl.obolibrary.org/obo/CHEBI_78608	alpha-amino-acid zwitterion		An α-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of 1-methylhistidine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_133609	3-methylhistidine zwitterion	http://purl.obolibrary.org/obo/CHEBI_78608	alpha-amino-acid zwitterion		An α-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of 3-methylhistidine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_133610	N-isobutyrylglycinate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion that is the conjugate base of <em>N</em>-isobutyrylglycine, obtained by deprotonation of the carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_133744	homovanillate	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		A  hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
http://purl.obolibrary.org/obo/CHEBI_134179	volatile organic compound	http://purl.obolibrary.org/obo/CHEBI_72695	organic molecule		Any organic compound having an initial boiling point less than or equal to 250 °C (482 °F) measured at a standard atmospheric pressure of 101.3 kPa.
http://purl.obolibrary.org/obo/CHEBI_134249	alkanesulfonate oxoanion	http://purl.obolibrary.org/obo/CHEBI_33554	organosulfonate oxoanion		An alkanesulfonate in which the carbon at position 1 is attached to R, which can represent hydrogens, a carbon chain, or other groups.
http://purl.obolibrary.org/obo/CHEBI_134251	guaiacols	http://purl.obolibrary.org/obo/CHEBI_33853	phenols		Any phenol carrying an additional methoxy substituent at the <em>ortho</em>-position.
http://purl.obolibrary.org/obo/CHEBI_13850	apoprotein	http://purl.obolibrary.org/obo/CHEBI_38560	simple protein		An apoprotein is a protein devoid of its characteristic prosthetic group or metal.
http://purl.obolibrary.org/obo/CHEBI_14321	glutamate(1-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group
http://purl.obolibrary.org/obo/CHEBI_15138	sulfide(2-)	http://purl.obolibrary.org/obo/CHEBI_79388	divalent inorganic anion		A divalent inorganic anion obtained by removal of both protons from hydrogen sulfide.
http://purl.obolibrary.org/obo/CHEBI_15318	xanthine	http://purl.obolibrary.org/obo/CHEBI_26386	purine nucleobase		A purine nucleobase found in humans and other organisms.
http://purl.obolibrary.org/obo/CHEBI_15339	acceptor	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity.
http://purl.obolibrary.org/obo/CHEBI_15356	cysteine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.
http://purl.obolibrary.org/obo/CHEBI_15676	allantoin	http://purl.obolibrary.org/obo/CHEBI_47857	ureas		An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.
http://purl.obolibrary.org/obo/CHEBI_15693	aldose	http://purl.obolibrary.org/obo/CHEBI_35381	monosaccharide		Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H, <em>n</em> ≥ 2) and their intramolecular hemiacetals.
http://purl.obolibrary.org/obo/CHEBI_15727	carnosine	http://purl.obolibrary.org/obo/CHEBI_46761	dipeptide		A dipeptide that is the <em>N</em>-(β-alanyl) derivative of <small>L</small>-histidine.
http://purl.obolibrary.org/obo/CHEBI_15740	formate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects.
http://purl.obolibrary.org/obo/CHEBI_15792	malonate(2-)	http://purl.obolibrary.org/obo/CHEBI_133291	saturated dicarboxylic acid dianion(2-)		A dicarboxylic acid dianion obtained by the deprotonation of the carboxy groups of malonic acid.
http://purl.obolibrary.org/obo/CHEBI_15963	ribitol	http://purl.obolibrary.org/obo/CHEBI_25899	pentitol		A pentitol (five-carbon sugar alcohol) having <i>meso</i>-configuration, being derived from ribose by reduction of the carbonyl group. It occurs naturally in the plant <em>Adonis vernalis</em>.
http://purl.obolibrary.org/obo/CHEBI_16042	halide anion	http://purl.obolibrary.org/obo/CHEBI_79389	monovalent inorganic anion		A monoatomic monoanion resulting from the addition of an electron to any halogen atom.
http://purl.obolibrary.org/obo/CHEBI_16134	ammonia	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms.
http://purl.obolibrary.org/obo/CHEBI_16136	hydrogen sulfide	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.
http://purl.obolibrary.org/obo/CHEBI_16137	chondroitin D-glucuronate	http://purl.obolibrary.org/obo/CHEBI_37395	mucopolysaccharide		A mucopolysaccharide composed of repeating β-<small>D</small>-glucopyranuronosyl-(1→3)-β-D-<em>N</em>-acetylgalactosaminyl units.
http://purl.obolibrary.org/obo/CHEBI_16189	sulfate	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.
http://purl.obolibrary.org/obo/CHEBI_16199	urea	http://purl.obolibrary.org/obo/CHEBI_29347	monocarboxylic acid amide		A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O).
http://purl.obolibrary.org/obo/CHEBI_16235	guanine	http://purl.obolibrary.org/obo/CHEBI_20702	2-aminopurines		A 2-aminopurine carrying a 6-oxo substituent.
http://purl.obolibrary.org/obo/CHEBI_16247	phospholipid	http://purl.obolibrary.org/obo/CHEBI_37734	phosphoric ester		A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides.
http://purl.obolibrary.org/obo/CHEBI_16285	phytanic acid	http://purl.obolibrary.org/obo/CHEBI_62499	methyl-branched fatty acid		A branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15.
http://purl.obolibrary.org/obo/CHEBI_16646	carbohydrate	http://purl.obolibrary.org/obo/CHEBI_78616	carbohydrates and carbohydrate derivatives		Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.
http://purl.obolibrary.org/obo/CHEBI_16716	benzene	http://purl.obolibrary.org/obo/CHEBI_33842	aromatic annulene		A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised π system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
http://purl.obolibrary.org/obo/CHEBI_16737	creatinine	http://purl.obolibrary.org/obo/CHEBI_55370	imidazolidinone		A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.
http://purl.obolibrary.org/obo/CHEBI_16750	guanosine	http://purl.obolibrary.org/obo/CHEBI_142355	purines D-ribonucleoside		A purine nucleoside in which guanine is attached to ribofuranose via a β-<em>N</em><small><sup>9</small></sup>-glycosidic bond.
http://purl.obolibrary.org/obo/CHEBI_16811	methionine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.
http://purl.obolibrary.org/obo/CHEBI_16813	galactitol	http://purl.obolibrary.org/obo/CHEBI_24583	hexitol		An optically inactive hexitol having <i>meso</i>-configuration.
http://purl.obolibrary.org/obo/CHEBI_16827	corticosterone	http://purl.obolibrary.org/obo/CHEBI_139590	primary alpha-hydroxy ketone		A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
http://purl.obolibrary.org/obo/CHEBI_16865	gamma-aminobutyric acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		A γ-amino acid that is butanoic acid with the amino substituent located at C-4.
http://purl.obolibrary.org/obo/CHEBI_16919	creatine	http://purl.obolibrary.org/obo/CHEBI_24436	guanidines		A glycine derivative having methyl and amidino groups attached to the nitrogen.
http://purl.obolibrary.org/obo/CHEBI_16990	bilirubin IXalpha	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		A member of the class of  biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.
http://purl.obolibrary.org/obo/CHEBI_16995	oxalic acid	http://purl.obolibrary.org/obo/CHEBI_28383	alpha,omega-dicarboxylic acid		An α,ω-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.
http://purl.obolibrary.org/obo/CHEBI_16997	propane-1,2-diol	http://purl.obolibrary.org/obo/CHEBI_26284	propane-1,2-diols		The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (−59°C) and high-boiling (188°C) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.
http://purl.obolibrary.org/obo/CHEBI_17026	progesterone	http://purl.obolibrary.org/obo/CHEBI_64600	C21-steroid hormone		A C<small><sub>21</sub></small>-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
http://purl.obolibrary.org/obo/CHEBI_17033	biliverdin	http://purl.obolibrary.org/obo/CHEBI_22869	bilins		A linear tetrapyrrole produced in the reticuloendothelial system by the first step of heme degradation, catalysed by heme oxygenase.
http://purl.obolibrary.org/obo/CHEBI_17089	glycoprotein	http://purl.obolibrary.org/obo/CHEBI_33837	conjugated protein		A compound in which a carbohydrate component is covalently bound to a protein component.
http://purl.obolibrary.org/obo/CHEBI_17113	erythritol	http://purl.obolibrary.org/obo/CHEBI_48299	butane-1,2,3,4-tetrol		The <i>meso</i>-diastereomer of butane-1,2,3,4-tetrol.
http://purl.obolibrary.org/obo/CHEBI_17128	adipate(2-)	http://purl.obolibrary.org/obo/CHEBI_133291	saturated dicarboxylic acid dianion(2-)		A dicarboxylic acid dianion obtained by the deprotonation of both the carboxy groups of adipic acid.
http://purl.obolibrary.org/obo/CHEBI_17230	homocysteine	http://purl.obolibrary.org/obo/CHEBI_24610	homocysteines		A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
http://purl.obolibrary.org/obo/CHEBI_17234	glucose	http://purl.obolibrary.org/obo/CHEBI_33917	aldohexose		An aldohexose used as a source of energy and metabolic intermediate.
http://purl.obolibrary.org/obo/CHEBI_17258	7H-purine	http://purl.obolibrary.org/obo/CHEBI_35584	purine		The 7<em>H</em>-tautomer of purine.
http://purl.obolibrary.org/obo/CHEBI_17359	sulfite	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H<small><sub>2</sub></small>SO<small><sub>3</sub></small>).
http://purl.obolibrary.org/obo/CHEBI_17368	hypoxanthine	http://purl.obolibrary.org/obo/CHEBI_67142	nucleobase analogue		A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
http://purl.obolibrary.org/obo/CHEBI_17376	cystine	http://purl.obolibrary.org/obo/CHEBI_35489	organic disulfide		A sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond.
http://purl.obolibrary.org/obo/CHEBI_17381	porphobilinogen	http://purl.obolibrary.org/obo/CHEBI_64365	aralkylamino compound		A dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively.
http://purl.obolibrary.org/obo/CHEBI_17453	methylmalonate(2-)	http://purl.obolibrary.org/obo/CHEBI_61336	C4-dicarboxylate		A C<small><sub>4</sub></small>-dicarboxylate resulting from the removal of a proton from both carboxylic acid groups of methylmalonic acid.
http://purl.obolibrary.org/obo/CHEBI_17485	homocystine	http://purl.obolibrary.org/obo/CHEBI_24612	homocystines		An organic disulfide obtained by oxidative dimerisation of homocysteine.
http://purl.obolibrary.org/obo/CHEBI_17544	hydrogencarbonate	http://purl.obolibrary.org/obo/CHEBI_35604	carbon oxoanion		The carbon oxoanion resulting from the removal of a proton from carbonic acid.
http://purl.obolibrary.org/obo/CHEBI_17578	toluene	http://purl.obolibrary.org/obo/CHEBI_38975	methylbenzene		The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent.
http://purl.obolibrary.org/obo/CHEBI_17650	cortisol	http://purl.obolibrary.org/obo/CHEBI_139592	tertiary alpha-hydroxy ketone		A 17α-hydroxy-C<small><sub>21</sub></small>-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses.
http://purl.obolibrary.org/obo/CHEBI_17755	cystathionine	http://purl.obolibrary.org/obo/CHEBI_16385	organic sulfide		A modified amino acid generated by enzymic means from homocysteine and serine.
http://purl.obolibrary.org/obo/CHEBI_17790	methanol	http://purl.obolibrary.org/obo/CHEBI_15734	primary alcohol		The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.
http://purl.obolibrary.org/obo/CHEBI_17792	organohalogen compound	http://purl.obolibrary.org/obo/CHEBI_37578	halide		A compound containing at least one carbon-halogen bond (where X is a halogen atom).
http://purl.obolibrary.org/obo/CHEBI_17822	serine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that is alanine substituted at position 3 by a hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_17823	calcitriol	http://purl.obolibrary.org/obo/CHEBI_73558	D3 vitamins		A hydroxycalciol that is calcidiol in which the <em>pro</em>-<i>S</i> hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D<small><sub>3</sub></small>, produced fom calciol <em>via</em> hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
http://purl.obolibrary.org/obo/CHEBI_17883	hydrogen chloride	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.
http://purl.obolibrary.org/obo/CHEBI_17891	donor	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity.
http://purl.obolibrary.org/obo/CHEBI_17933	calcidiol	http://purl.obolibrary.org/obo/CHEBI_73558	D3 vitamins		A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D<small><sub>3</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_18085	glycosaminoglycan	http://purl.obolibrary.org/obo/CHEBI_22506	aminoglycan		Any polysaccharide containing a substantial proportion of aminomonosaccharide residues.
http://purl.obolibrary.org/obo/CHEBI_18139	trimethylamine	http://purl.obolibrary.org/obo/CHEBI_25274	methylamines		A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group.
http://purl.obolibrary.org/obo/CHEBI_18154	polysaccharide	http://purl.obolibrary.org/obo/CHEBI_167559	glycan		A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues.
http://purl.obolibrary.org/obo/CHEBI_18186	tyrosine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.
http://purl.obolibrary.org/obo/CHEBI_18211	citrulline	http://purl.obolibrary.org/obo/CHEBI_23324	citrullines		The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the <em>N</em><small><sup>5</small></sup>-position.
http://purl.obolibrary.org/obo/CHEBI_18237	glutamic acid	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that is glutaric acid bearing a single amino substituent at position 2.
http://purl.obolibrary.org/obo/CHEBI_18248	iron atom	http://purl.obolibrary.org/obo/CHEBI_33356	iron group element atom		An iron group element atom that has atomic number 26.
http://purl.obolibrary.org/obo/CHEBI_18257	ornithine	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		An α-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.
http://purl.obolibrary.org/obo/CHEBI_18282	nucleobase	http://purl.obolibrary.org/obo/CHEBI_38101	organonitrogen heterocyclic compound		That part of DNA or RNA that may be involved in pairing.
http://purl.obolibrary.org/obo/CHEBI_18367	phosphate(3-)	http://purl.obolibrary.org/obo/CHEBI_35780	phosphate ion		A phosphate ion that is the conjugate base of hydrogenphosphate.
http://purl.obolibrary.org/obo/CHEBI_18376	dermatan sulfate	http://purl.obolibrary.org/obo/CHEBI_35722	sulfated glycosaminoglycan		Any of a group of glycosaminoglycans with repeating units consisting of variously sulfated β1→4-linked <small>L</small>-iduronyl-(α1→3)-<em>N</em>-acetyl-<small>D</small>-galactosamine units.
http://purl.obolibrary.org/obo/CHEBI_18401	phenylacetate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion that is the conjugate base of phenylacetic acid.
http://purl.obolibrary.org/obo/CHEBI_18408	cobamamide	http://purl.obolibrary.org/obo/CHEBI_23334	cobalamins		A member of the class of cobalamins that is vitamin B<small><sub>12</sub></small> in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B<small><sub>12</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_21760	N-methyl-amino acid	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative in which at least one of the hydrogens of the amino group has been replaced by a methyl group.
http://purl.obolibrary.org/obo/CHEBI_21766	N-methylglycines	http://purl.obolibrary.org/obo/CHEBI_66933	N-alkylglycine		An <em>N</em>-alkylglycine that is sarcosine and derivatives of sarcosine arising by replacement of the hydrogen attached to the nitrogen by a hydrocarbyl group.
http://purl.obolibrary.org/obo/CHEBI_22331	alkylamines	http://purl.obolibrary.org/obo/CHEBI_32952	amine		Any amine formally derived from ammonia by replacing one, two or three hydrogen atoms by alkyl groups.
http://purl.obolibrary.org/obo/CHEBI_22660	aspartic acid	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that consists of succinic acid bearing a single α-amino substituent
http://purl.obolibrary.org/obo/CHEBI_22718	benzoates	http://purl.obolibrary.org/obo/CHEBI_91007	aromatic carboxylate		A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid.
http://purl.obolibrary.org/obo/CHEBI_23044	carotenoid	http://purl.obolibrary.org/obo/CHEBI_26935	tetraterpenoid		One of a class of tetraterpenoids (C<small><sub>40</sub></small>), formally derived from the acyclic parent, ψ,ψ-carotene by hydrogenation, dehydrogenation, cyclization, oxidation, or combination of these processes. This class includes carotenes, xanthophylls and certain compounds that arise from rearrangement of the skeleton of ψ,ψ-carotene or by loss of part of this structure. Retinoids are excluded.
http://purl.obolibrary.org/obo/CHEBI_23509	cysteine derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues.
http://purl.obolibrary.org/obo/CHEBI_23888	drug	http://purl.obolibrary.org/obo/CHEBI_52217	pharmaceutical		Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
http://purl.obolibrary.org/obo/CHEBI_23924	enzyme inhibitor	http://purl.obolibrary.org/obo/CHEBI_52206	biochemical role		A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
http://purl.obolibrary.org/obo/CHEBI_24403	glycosyl group	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		An organic group obtained by removing the hydroxy group from the hemiacetal function of a monosaccharide or monosaccharide derivative and, by extension, of a lower oligosaccharide or oligosaccharide derivative.
http://purl.obolibrary.org/obo/CHEBI_24433	group	http://purl.obolibrary.org/obo/CHEBI_24431	chemical entity		A defined linked collection of atoms or a single atom within a molecular entity.
http://purl.obolibrary.org/obo/CHEBI_24621	hormone	http://purl.obolibrary.org/obo/CHEBI_33280	molecular messenger		Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
http://purl.obolibrary.org/obo/CHEBI_24662	hydroxy-amino acid	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		A non-proteinogenic α-amino acid bearing one or more hydroxy groups at unspecified positions.
http://purl.obolibrary.org/obo/CHEBI_24913	isoprenoid	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives.
http://purl.obolibrary.org/obo/CHEBI_25017	leucine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the α-carbon is substituted by an isobutyl group.
http://purl.obolibrary.org/obo/CHEBI_25362	elemental molecule	http://purl.obolibrary.org/obo/CHEBI_33259	elemental molecular entity		A molecule all atoms of which have the same atomic number.
http://purl.obolibrary.org/obo/CHEBI_25676	oligopeptide	http://purl.obolibrary.org/obo/CHEBI_16670	peptide		A peptide containing a relatively small number of amino acids.
http://purl.obolibrary.org/obo/CHEBI_25704	organic sulfate	http://purl.obolibrary.org/obo/CHEBI_37826	sulfuric acid derivative		Compounds of the general formula SO3HOR where R is an organyl group
http://purl.obolibrary.org/obo/CHEBI_25728	osmolyte	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A solute used by a cell under water stress to maintain cell volume.
http://purl.obolibrary.org/obo/CHEBI_25905	peptide hormone	http://purl.obolibrary.org/obo/CHEBI_16670	peptide		Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine.
http://purl.obolibrary.org/obo/CHEBI_26333	prostaglandin	http://purl.obolibrary.org/obo/CHEBI_26347	prostanoid		Naturally occurring compounds derived from the parent C<small><sub>20</sub></small> acid, prostanoic acid.
http://purl.obolibrary.org/obo/CHEBI_26348	prosthetic group	http://purl.obolibrary.org/obo/CHEBI_23357	cofactor		A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity.
http://purl.obolibrary.org/obo/CHEBI_26386	purine nucleobase	http://purl.obolibrary.org/obo/CHEBI_26401	purines		A nucleobase whose skeleton is derived from purine.
http://purl.obolibrary.org/obo/CHEBI_26463	pyruvate family amino acid	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		An <small>L</small>-α-amino acid which is biosynthesised from pyruvate (i.e. alanine, valine, and leucine). A closed class.
http://purl.obolibrary.org/obo/CHEBI_26649	serine derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of serine by a heteroatom. The definition normally excludes peptides containing serine residues.
http://purl.obolibrary.org/obo/CHEBI_26650	serine family amino acid	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid which is biosynthesised from 3-phosphoglycerate (i.e. serine, glycine, cysteine and homocysteine). A closed class.
http://purl.obolibrary.org/obo/CHEBI_26666	short-chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		An aliphatic monocarboxylic acid with a chain length of less than C<small><sub>6</sub></small>. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.
http://purl.obolibrary.org/obo/CHEBI_26819	sulfuric ester	http://purl.obolibrary.org/obo/CHEBI_37826	sulfuric acid derivative		An ester of an alcohol and sulfuric acid.
http://purl.obolibrary.org/obo/CHEBI_26907	tetrahydrofolic acid	http://purl.obolibrary.org/obo/CHEBI_37445	folic acids		A group of heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more <small>L</small>-glutamic acid units.
http://purl.obolibrary.org/obo/CHEBI_27027	micronutrient	http://purl.obolibrary.org/obo/CHEBI_33284	nutrient		Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
http://purl.obolibrary.org/obo/CHEBI_27207	univalent carboacyl group	http://purl.obolibrary.org/obo/CHEBI_37838	carboacyl group		A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_27208	unsaturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid containing at least one C=C or C≡C bond.
http://purl.obolibrary.org/obo/CHEBI_27622	vanillylmandelate	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		A hydroxy monocarboxylic acid anion that is the conjugate base of vanillylmandelic acid.
http://purl.obolibrary.org/obo/CHEBI_28358	rac-lactic acid	http://purl.obolibrary.org/obo/CHEBI_60911	racemate		A racemate comprising equimolar amounts of (<i>R</i>)- and (<i>S</i>)-lactic acid.
http://purl.obolibrary.org/obo/CHEBI_28616	carbamic acid	http://purl.obolibrary.org/obo/CHEBI_35605	carbon oxoacid		A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised.
http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid.
http://purl.obolibrary.org/obo/CHEBI_29987	glutamate(2-)	http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion		A dicarboxylic acid dianion that is the conjugate base of glutamate(1−).
http://purl.obolibrary.org/obo/CHEBI_30768	propionic acid	http://purl.obolibrary.org/obo/CHEBI_26666	short-chain fatty acid		A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.
http://purl.obolibrary.org/obo/CHEBI_30769	citric acid	http://purl.obolibrary.org/obo/CHEBI_27093	tricarboxylic acid		A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
http://purl.obolibrary.org/obo/CHEBI_30794	malonic acid	http://purl.obolibrary.org/obo/CHEBI_28383	alpha,omega-dicarboxylic acid		An α,ω-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.
http://purl.obolibrary.org/obo/CHEBI_30879	alcohol	http://purl.obolibrary.org/obo/CHEBI_33822	organic hydroxy compound		A compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom.
http://purl.obolibrary.org/obo/CHEBI_3098	bile acid	http://purl.obolibrary.org/obo/CHEBI_138366	bile acids		Any member of a group of hydroxy-5β-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration.
http://purl.obolibrary.org/obo/CHEBI_32456	cysteinate(1-)	http://purl.obolibrary.org/obo/CHEBI_63470	sulfur-containing amino-acid anion		A sulfur-containing amino-acid anion that is the conjugate base of cysteine, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32507	glycinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of glycine, arising from protonation of the amino.
http://purl.obolibrary.org/obo/CHEBI_32508	glycinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of glycine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32926	octadecane	http://purl.obolibrary.org/obo/CHEBI_83563	long-chain alkane		A straight-chain alkane carrying 18 carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_33249	organyl group	http://purl.obolibrary.org/obo/CHEBI_51447	organic univalent group		Any organic substituent group, regardless of functional type, having one free valence at a carbon atom.
http://purl.obolibrary.org/obo/CHEBI_33252	atomic nucleus	http://purl.obolibrary.org/obo/CHEBI_36347	nuclear particle		A nucleus is the positively charged central portion of an atom, excluding the orbital electrons.
http://purl.obolibrary.org/obo/CHEBI_33284	nutrient	http://purl.obolibrary.org/obo/CHEBI_78295	food component		A nutrient is a food component that an organism uses to survive and grow.
http://purl.obolibrary.org/obo/CHEBI_33709	amino acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		A carboxylic acid containing one or more amino groups.
http://purl.obolibrary.org/obo/CHEBI_33838	nucleoside	http://purl.obolibrary.org/obo/CHEBI_21731	N-glycosyl compound		An <em>N</em>-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents.
http://purl.obolibrary.org/obo/CHEBI_35107	azane	http://purl.obolibrary.org/obo/CHEBI_35106	nitrogen hydride		Saturated acyclic nitrogen hydrides having the general formula N<small><sub><em>n</em></sub></small>H<small><sub><em>n</em>+2</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_35190	diterpene	http://purl.obolibrary.org/obo/CHEBI_35186	terpene		A C<small><sub>20</sub></small> terpene.
http://purl.obolibrary.org/obo/CHEBI_35267	quaternary ammonium ion	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.
http://purl.obolibrary.org/obo/CHEBI_35342	17alpha-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_36838	17-hydroxy steroid		The α-stereoisomer of 17-hydroxy steroid.
http://purl.obolibrary.org/obo/CHEBI_35346	11beta-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_36841	11-hydroxy steroid		Any 11-hydroxy steroid in which the hydroxy group at position 11 has β- configuration.
http://purl.obolibrary.org/obo/CHEBI_35522	beta-adrenergic agonist	http://purl.obolibrary.org/obo/CHEBI_48540	beta-adrenergic drug		An agent that selectively binds to and activates β-adrenergic receptors.
http://purl.obolibrary.org/obo/CHEBI_35524	sympathomimetic agent	http://purl.obolibrary.org/obo/CHEBI_37962	adrenergic agent		A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
http://purl.obolibrary.org/obo/CHEBI_35554	cardiovascular drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		Any dicarboxylic acid anion that is a monoanion obtained by the deprotonation of only one of the carboxy groups of the dicarboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_35819	branched-chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids.
http://purl.obolibrary.org/obo/CHEBI_35987	diamino acid	http://purl.obolibrary.org/obo/CHEBI_33709	amino acid		Any amino acid carrying two amino groups.
http://purl.obolibrary.org/obo/CHEBI_36063	oxytocic	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (abortifacients).
http://purl.obolibrary.org/obo/CHEBI_36080	protein	http://purl.obolibrary.org/obo/CHEBI_33695	information biomacromolecule		A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome.
http://purl.obolibrary.org/obo/CHEBI_36145	oxo dicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_25754	oxo carboxylic acid		Any dicarboxylic acid carrying one or more oxo groups.
http://purl.obolibrary.org/obo/CHEBI_36544	sialodiosylceramide	http://purl.obolibrary.org/obo/CHEBI_28892	ganglioside		A ganglioside in which the number of residues in the oligosaccharide chain is two.
http://purl.obolibrary.org/obo/CHEBI_36735	biladienes	http://purl.obolibrary.org/obo/CHEBI_25046	linear tetrapyrrole		Compounds based on a biladiene skeleton.
http://purl.obolibrary.org/obo/CHEBI_36885	20-oxo steroid	http://purl.obolibrary.org/obo/CHEBI_35789	oxo steroid		An oxo steroid carrying an oxo group at position 20.
http://purl.obolibrary.org/obo/CHEBI_37257	phytanate	http://purl.obolibrary.org/obo/CHEBI_57560	long-chain fatty acid anion		A branched-chain saturated fatty acid anion that is the conjugate base of phytanic acid, arising from deprotonation of the carboxylic acid group.
http://purl.obolibrary.org/obo/CHEBI_37527	acid	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		An acid is a molecular entity capable of donating a hydron (Brønsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).
http://purl.obolibrary.org/obo/CHEBI_37684	mannose	http://purl.obolibrary.org/obo/CHEBI_33917	aldohexose		An aldohexose that is the C-2 epimer of glucose.
http://purl.obolibrary.org/obo/CHEBI_41865	sebacic acid	http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid		An α,ω-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane.
http://purl.obolibrary.org/obo/CHEBI_41941	(3,4-dihydroxyphenyl)acetic acid	http://purl.obolibrary.org/obo/CHEBI_33566	catechols		A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
http://purl.obolibrary.org/obo/CHEBI_42111	(R)-lactic acid	http://purl.obolibrary.org/obo/CHEBI_78320	2-hydroxypropanoic acid		An optically active form of lactic acid having (<i>R</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_46842	sarcosinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of sarcosine, arising from protonation of the amino group.
http://purl.obolibrary.org/obo/CHEBI_46904	oxalate(1-)	http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion		A dicarboxylic acid monoanion that is the conjugate base of oxalic acid.
http://purl.obolibrary.org/obo/CHEBI_46915	sarcosinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of sarcosine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_47778	glyceride	http://purl.obolibrary.org/obo/CHEBI_35741	glycerolipid		Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.
http://purl.obolibrary.org/obo/CHEBI_47909	3-oxo-Delta(4) steroid	http://purl.obolibrary.org/obo/CHEBI_51689	enone		A 3-oxo steroid conjugated to a C=C double bond at the α,β position.
http://purl.obolibrary.org/obo/CHEBI_48360	amphiprotic solvent	http://purl.obolibrary.org/obo/CHEBI_48359	protophilic solvent		Self-ionizing solvent possessing both characteristics of Brønsted acids and bases.
http://purl.obolibrary.org/obo/CHEBI_49110	peripheral nervous system drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
http://purl.obolibrary.org/obo/CHEBI_50126	tetrasaccharide	http://purl.obolibrary.org/obo/CHEBI_50699	oligosaccharide		An oligosaccharide comprising four monomeric monosaccharide units.
http://purl.obolibrary.org/obo/CHEBI_50247	antidote	http://purl.obolibrary.org/obo/CHEBI_50267	protective agent		Any protective agent counteracting or neutralizing the action of poisons.
http://purl.obolibrary.org/obo/CHEBI_50699	oligosaccharide	http://purl.obolibrary.org/obo/CHEBI_167559	glycan		A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues.
http://purl.obolibrary.org/obo/CHEBI_50910	neurotoxin	http://purl.obolibrary.org/obo/CHEBI_52209	aetiopathogenetic role		A poison that interferes with the functions of the nervous system.
http://purl.obolibrary.org/obo/CHEBI_51086	chemical role	http://purl.obolibrary.org/obo/CHEBI_50906	role		A role played by the molecular entity or part thereof within a chemical context.
http://purl.obolibrary.org/obo/CHEBI_53487	all-cis-docosa-7,10,13,16-tetraenoic acid	http://purl.obolibrary.org/obo/CHEBI_36009	omega-6 fatty acid		The <i>all</i>-<i>cis</i>-isomer of a C<small><sub>22</sub></small> polyunsaturated fatty acid having four double bonds in the 7-, 10-, 13- and 16-positions. One of the most abundant fatty acids in the early human brain.
http://purl.obolibrary.org/obo/CHEBI_57305	glycine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of glycine.
http://purl.obolibrary.org/obo/CHEBI_57433	sarcosine zwitterion	http://purl.obolibrary.org/obo/CHEBI_66884	N-alkylglycine zwitterion		An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of sarcosine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57485	carnosine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of carnosine.
http://purl.obolibrary.org/obo/CHEBI_57925	glutathionate(1-)	http://purl.obolibrary.org/obo/CHEBI_60334	peptide anion		A peptide anion obtained by deprotonation of both carboxy groups and protonation of the glutamyl amino group of glutathione; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58942	cationic amino-acid residue	http://purl.obolibrary.org/obo/CHEBI_64769	organic cationic group		An amino-acid residue protonated on nitrogen.
http://purl.obolibrary.org/obo/CHEBI_58951	short-chain fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C<small><sub>6</sub></small>).
http://purl.obolibrary.org/obo/CHEBI_58956	branched-chain saturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_58955	branched-chain fatty acid anion		Any saturated fatty acid anion with a carbon side-chain or isopropyl termination.
http://purl.obolibrary.org/obo/CHEBI_58958	organosulfate oxoanion	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		An organic anion of general formula RS(=O)2O(−) where R is an organyl group.
http://purl.obolibrary.org/obo/CHEBI_59174	hapten	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		Any substance capable of eliciting an immune response only when attached to a large carrier such as a protein. Examples include dinitrophenols; oligosaccharides; peptides; and heavy metals.
http://purl.obolibrary.org/obo/CHEBI_59202	straight-chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid whose skeletal carbon atoms form an unbranched open chain.
http://purl.obolibrary.org/obo/CHEBI_59203	straight-chain fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid.
http://purl.obolibrary.org/obo/CHEBI_59252	linear tetrapyrrole anion	http://purl.obolibrary.org/obo/CHEBI_25696	organic anion		An organic anion arising from deprotonation of a acyclic tetrapyrrole compound.
http://purl.obolibrary.org/obo/CHEBI_59740	nucleophilic reagent	http://purl.obolibrary.org/obo/CHEBI_39144	Lewis base		A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
http://purl.obolibrary.org/obo/CHEBI_59789	S-adenosyl-L-methionine zwitterion	http://purl.obolibrary.org/obo/CHEBI_25697	organic cation		A zwitterionic tautomer of <em>S</em>-adenosyl-<small>L</small>-methionine arising from shift of the proton from the carboxy group to the amino group.
http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		Conjugate base of an <small>L</small>-α-amino acid arising from deprotonation of the C-1 carboxy group.
http://purl.obolibrary.org/obo/CHEBI_59869	L-alpha-amino acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_78608	alpha-amino-acid zwitterion		Zwitterionic form of an <small>L</small>-α-amino acid having an anionic carboxy group and a protonated amino group.
http://purl.obolibrary.org/obo/CHEBI_60065	alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine(1-)	http://purl.obolibrary.org/obo/CHEBI_88071	monosialodiglycosylceramide(1-)		A carbohydrate acid derivative anion that is the conjugate base of α-<em>N</em>-acetylneuraminosyl-(2→3)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucosylceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_60242	monovalent inorganic cation	http://purl.obolibrary.org/obo/CHEBI_36915	inorganic cation		An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one.
http://purl.obolibrary.org/obo/CHEBI_60466	peptide zwitterion	http://purl.obolibrary.org/obo/CHEBI_27369	zwitterion		Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged.
http://purl.obolibrary.org/obo/CHEBI_606564	prostaglandin E2(1-)	http://purl.obolibrary.org/obo/CHEBI_59326	prostaglandin carboxylic acid anion		The conjugate base of prostaglandin E<small><sub>2</sub></small>; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_61313	C21-steroid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		A steroid that has a structure based on a 21-carbon (pregnane) skeleton. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure.
http://purl.obolibrary.org/obo/CHEBI_61336	C4-dicarboxylate	http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion		A dicarboxylate that contains four carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_62081	1,1-diunsubstituted alkanesulfonate	http://purl.obolibrary.org/obo/CHEBI_134249	alkanesulfonate oxoanion		An alkanesulfonate in which the carbon at position 1 is attached to at least two hydrogens.
http://purl.obolibrary.org/obo/CHEBI_62943	prostanoid anion	http://purl.obolibrary.org/obo/CHEBI_62937	icosanoid anion		An icosanoid anion that is the conjugate base of a prostanoid.
http://purl.obolibrary.org/obo/CHEBI_63248	oxidising agent	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A substance that removes electrons from another reactant in a redox reaction.
http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative	http://purl.obolibrary.org/obo/CHEBI_78616	carbohydrates and carbohydrate derivatives		Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.
http://purl.obolibrary.org/obo/CHEBI_63563	oligosaccharide derivative	http://purl.obolibrary.org/obo/CHEBI_167559	glycan		A carbohydrate derivative that is formally obtained from an oligosaccharide.
http://purl.obolibrary.org/obo/CHEBI_64390	N-hexanoylglycine	http://purl.obolibrary.org/obo/CHEBI_16180	N-acylglycine		An <em>N</em>-acylglycine in which the acyl group is specified as hexanoyl.
http://purl.obolibrary.org/obo/CHEBI_64570	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76874	EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor		An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of glycine hydroxymethyltransferase (EC 2.1.2.1).
http://purl.obolibrary.org/obo/CHEBI_64584	uremic toxin	http://purl.obolibrary.org/obo/CHEBI_27026	toxin		A toxin that accumulates in patients with chronic kidney disease.
http://purl.obolibrary.org/obo/CHEBI_64588	glycine transporter 1 inhibitor	http://purl.obolibrary.org/obo/CHEBI_85425	glycine transporter inhibitor		Any glycine transporter inhibitor that interferes with the action of glycine 1 transporters.
http://purl.obolibrary.org/obo/CHEBI_64589	glycine receptor agonist	http://purl.obolibrary.org/obo/CHEBI_48705	agonist		An agonist that binds to and activates glycine receptors
http://purl.obolibrary.org/obo/CHEBI_64769	organic cationic group	http://purl.obolibrary.org/obo/CHEBI_64766	cationic group		A cationic group that contains carbon.
http://purl.obolibrary.org/obo/CHEBI_66873	C4-dicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		Any dicarboxylic acid that contains four carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_66874	carnosinate	http://purl.obolibrary.org/obo/CHEBI_59874	N-acyl-L-alpha-amino acid anion		An <em>N</em>-acyl-<small>L</small>-α-amino acid anion that is the conjugate base of carnosine, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_66933	N-alkylglycine	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		Any glycine derivative in which glycine is substituted at position 2 by an alkyl group.
http://purl.obolibrary.org/obo/CHEBI_67013	methyl-branched fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_58955	branched-chain fatty acid anion		Any branched-chain fatty acid anion containing methyl branches only.
http://purl.obolibrary.org/obo/CHEBI_67040	S-adenosyl-L-methioninate	http://purl.obolibrary.org/obo/CHEBI_35282	sulfonium betaine		A sulfonium betaine that is a conjugate base of <i>S</i>-adenosyl-<small>L</small>-methionine obtained by the deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_70958	1-methylhistidine	http://purl.obolibrary.org/obo/CHEBI_137682	methylhistidine		A methylhistidine in which the methyl group is located at N-1.
http://purl.obolibrary.org/obo/CHEBI_70959	3-methylhistidine	http://purl.obolibrary.org/obo/CHEBI_137682	methylhistidine		A methylhistidine in which the methyl group is located at N-3.
http://purl.obolibrary.org/obo/CHEBI_70979	N-isobutyrylglycine	http://purl.obolibrary.org/obo/CHEBI_16180	N-acylglycine		An <em>N</em>-acylglycine in which the acyl group is specified as isobutryl.
http://purl.obolibrary.org/obo/CHEBI_72695	organic molecule	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
http://purl.obolibrary.org/obo/CHEBI_73336	vulnerary	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug used in treating and healing of wounds.
http://purl.obolibrary.org/obo/CHEBI_74345	1-(5-hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)urea	http://purl.obolibrary.org/obo/CHEBI_55370	imidazolidinone		An imidazolidinone that is imidazolin-2-one substituted at positions 4 and 5 by hydroxy and ureido groups respectively.
http://purl.obolibrary.org/obo/CHEBI_76413	greenhouse gas	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A gas in an atmosphere that absorbs and emits radiation within the thermal infrared range, so contributing to the 'greenhouse effect'.
http://purl.obolibrary.org/obo/CHEBI_76807	EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76764	EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor		An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).
http://purl.obolibrary.org/obo/CHEBI_77941	EC 3.5.1.4 (amidase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76807	EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor		An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
http://purl.obolibrary.org/obo/CHEBI_77974	food packaging gas	http://purl.obolibrary.org/obo/CHEBI_64047	food additive		A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.
http://purl.obolibrary.org/obo/CHEBI_78049	octadecenoate	http://purl.obolibrary.org/obo/CHEBI_82680	monounsaturated fatty acid anion		A fatty acid anion containing 18 carbons and one double bond. Formed by deprotonation of the carboxylic acid group. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78675	fundamental metabolite	http://purl.obolibrary.org/obo/CHEBI_25212	metabolite		Any metabolite produced by all living cells.
http://purl.obolibrary.org/obo/CHEBI_78803	nematode metabolite	http://purl.obolibrary.org/obo/CHEBI_75767	animal metabolite		An animal metabolite produced by any member of the phylum Nematoda.
http://purl.obolibrary.org/obo/CHEBI_7896	hexadecanoate	http://purl.obolibrary.org/obo/CHEBI_83955	2-saturated fatty acid anion		A long-chain fatty acid anion that is the conjugate base of hexadecanoic acid (palmitic acid); major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_79209	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide	http://purl.obolibrary.org/obo/CHEBI_36544	sialodiosylceramide		A sialodiaosylceramide consisting of the trisaccharide α-<em>N</em>-acetylneuraminyl-(2→3)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucose attached to the primary hydroxy function of a ceramide with undefined sphingoid base.
http://purl.obolibrary.org/obo/CHEBI_79388	divalent inorganic anion	http://purl.obolibrary.org/obo/CHEBI_24834	inorganic anion		Any inorganic anion with a valency of two.
http://purl.obolibrary.org/obo/CHEBI_83812	non-proteinogenic amino acid derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_83982	L-glutamic acid derivative	http://purl.obolibrary.org/obo/CHEBI_24315	glutamic acid derivative		A proteinogenic amino acid derivative resulting from reaction of <small>L</small>-glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of <small>L</small>-glutamic acid by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_84196	3-hydroxy fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_59835	hydroxy fatty acid anion		A hydroxy fatty acid anion obtained by deprotonation of the carboxy group of any 3-hydroxy fatty acid.
http://purl.obolibrary.org/obo/CHEBI_87691	tetradecanoate ester	http://purl.obolibrary.org/obo/CHEBI_35748	fatty acid ester		A fatty acid ester obtained by condensation of the carboxy group of tetradecanoic acid (also known as myristic acid) with a hydroxy group of an alcohol or phenol.
http://purl.obolibrary.org/obo/CHEBI_90799	dipeptide zwitterion	http://purl.obolibrary.org/obo/CHEBI_60466	peptide zwitterion		Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_91315	2-methylbutanedioic acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group.
http://purl.obolibrary.org/obo/CHEBI_9300	suberic acid	http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid		An α,ω-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.
http://purl.obolibrary.org/obo/CHEBI_29340	hydridonitrate(2-)	http://purl.obolibrary.org/obo/CHEBI_35106	nitrogen hydride		A divalent inorganic anion resulting from the removal of two protons from ammonia.
http://purl.obolibrary.org/obo/CHEBI_29888	diphosphoric acid	http://purl.obolibrary.org/obo/CHEBI_33457	phosphorus oxoacid		An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid.
http://purl.obolibrary.org/obo/CHEBI_29994	D-aspartate(2-)	http://purl.obolibrary.org/obo/CHEBI_29995	aspartate(2-)		An aspartate(2−) that is the conjugate base of <small>D</small>-aspartate(1−).
http://purl.obolibrary.org/obo/CHEBI_29995	aspartate(2-)	http://purl.obolibrary.org/obo/CHEBI_61336	C4-dicarboxylate		A C4-dicarboxylate that is the dianion obtained by the deprotonation of both the carboxy groups of aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_30807	tetradecanoate	http://purl.obolibrary.org/obo/CHEBI_83955	2-saturated fatty acid anion		A long-chain fatty acid anion that is the conjugate base of myristic acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_31014	tetracosanoate	http://purl.obolibrary.org/obo/CHEBI_83955	2-saturated fatty acid anion		A straight-chain saturated fatty acid anion that is the conjugate base of tetracosanoic acid (lignoceric acid), formed by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_33017	diphosphate(1-)	http://purl.obolibrary.org/obo/CHEBI_79389	monovalent inorganic anion		A monovalent inorganic anion obtained by deprotonation of one of the phosphate OH groups in diphosphoric acid.
http://purl.obolibrary.org/obo/CHEBI_33246	inorganic group	http://purl.obolibrary.org/obo/CHEBI_24433	group		Any substituent group which does not contain carbon.
http://purl.obolibrary.org/obo/CHEBI_33543	sulfonate	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		The sulfur oxoanion formed by deprotonation of sulfonic acid.
http://purl.obolibrary.org/obo/CHEBI_33568	adrenaline	http://purl.obolibrary.org/obo/CHEBI_60911	racemate		A racemate comprising equimolar amounts of (<i>R</i>)-adrenaline and (<i>S</i>)-adrenaline.
http://purl.obolibrary.org/obo/CHEBI_33658	arene	http://purl.obolibrary.org/obo/CHEBI_33663	cyclic hydrocarbon		Any monocyclic or polycyclic aromatic hydrocarbon.
http://purl.obolibrary.org/obo/CHEBI_33702	polyatomic cation	http://purl.obolibrary.org/obo/CHEBI_36916	cation		A cation consisting of more than one atom.
http://purl.obolibrary.org/obo/CHEBI_350546	serotonin(1+)	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_35621	alpha-aminobutyric acid	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		An α-amino acid that is butyric acid bearing a single amino substituent located at position 2.
http://purl.obolibrary.org/obo/CHEBI_37886	adrenergic agonist	http://purl.obolibrary.org/obo/CHEBI_37962	adrenergic agent		An agent that selectively binds to and activates adrenergic receptors.
http://purl.obolibrary.org/obo/CHEBI_38716	carboxylic acid dianion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		Any dianion containing at least one carboxy group.
http://purl.obolibrary.org/obo/CHEBI_40751	(S)-adrenaline	http://purl.obolibrary.org/obo/CHEBI_194548	4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol		The <i>S</i>-enantiomer of adrenaline.
http://purl.obolibrary.org/obo/CHEBI_50313	onium cation	http://purl.obolibrary.org/obo/CHEBI_50312	onium compound		Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families.
http://purl.obolibrary.org/obo/CHEBI_50745	progestogen	http://purl.obolibrary.org/obo/CHEBI_50112	sex hormone		A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone.
http://purl.obolibrary.org/obo/CHEBI_51060	hormone agonist	http://purl.obolibrary.org/obo/CHEBI_51061	hormone receptor modulator		A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
http://purl.obolibrary.org/obo/CHEBI_61660	organic sulfamate oxoanion	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		An anion resulting from the removal of a proton from an organic sulfamic acid group.
http://purl.obolibrary.org/obo/CHEBI_62031	polar amino acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group.
http://purl.obolibrary.org/obo/CHEBI_63056	zinc cation	http://purl.obolibrary.org/obo/CHEBI_27365	zinc ion		Any zinc ion that is positively charged.
http://purl.obolibrary.org/obo/CHEBI_64857	cosmetic	http://purl.obolibrary.org/obo/CHEBI_33232	application		The role played by a substance in enhancing the appearance or odour of the human body; a name given to the substance itself or to a component of it.
http://purl.obolibrary.org/obo/CHEBI_68830	O-decanoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine compound having decanoyl as the acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_71406	(R)-adrenaline(1+)	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		An organic cation that is the conjugate acid of (<i>R</i>)-adrenaline, obtained by protonation of the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_42090	L-threitol	http://purl.obolibrary.org/obo/CHEBI_26981	threitol		The <small>L</small>-enantiomer of threitol.
http://purl.obolibrary.org/obo/CHEBI_43799	butan-1-amine	http://purl.obolibrary.org/obo/CHEBI_17062	primary aliphatic amine		A primary aliphatic amine that is butane substituted by an amino group at position 1.
http://purl.obolibrary.org/obo/CHEBI_48300	D-threitol	http://purl.obolibrary.org/obo/CHEBI_26981	threitol		The <small>D</small>-enantiomer of threitol.
http://purl.obolibrary.org/obo/CHEBI_60059	dermatan anion	http://purl.obolibrary.org/obo/CHEBI_63551	carbohydrate acid derivative anion		A carbohydrate acid derivative anion obtained from dermatan by deprotonation of the carboxylic acid groups of the repeating units; the major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_85338	L-alloisoleucine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion resulting from a transfer of a proton from the carboxy group to the amino group of <small>L</small>-alloisoleucine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_87657	octanoate ester	http://purl.obolibrary.org/obo/CHEBI_35748	fatty acid ester		Any fatty acid ester in which the carboxylic acid component is octanoic acid (caprylic acid).
http://purl.obolibrary.org/obo/CHEBI_59226	N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose	http://purl.obolibrary.org/obo/CHEBI_151472	N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose		An amino trisaccharide that is the carbohydrate portion of ganglioside GM3. It comprises a linear sequence of α-<em>N</em>-acetylneuraminyl, β-<small>D</small>-galactosyl and β-<small>D</small>-glucose residues linked (2→3) and (1→4).
http://purl.obolibrary.org/obo/CHEBI_5931	insulin (human)	http://purl.obolibrary.org/obo/CHEBI_145810	insulin		An insulin that is produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two peptide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into <em>E. coli</em>, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes.
http://purl.obolibrary.org/obo/CHEBI_64641	divalent inorganic cation	http://purl.obolibrary.org/obo/CHEBI_36915	inorganic cation		An inorganic cation with a valency of two.
http://purl.obolibrary.org/obo/CHEBI_75600	EC 6.3.* (C-N bond-forming ligase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_75603	EC 6.* (ligase) inhibitor		A ligase inhibitor that interferes with the action of a <em>C</em>‒<em>N</em> bond-forming ligase (EC 6.3.*.*).
http://purl.obolibrary.org/obo/CHEBI_76759	EC 3.* (hydrolase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_23924	enzyme inhibitor		Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
http://purl.obolibrary.org/obo/CHEBI_79346	anionic ganglioside	http://purl.obolibrary.org/obo/CHEBI_63551	carbohydrate acid derivative anion		Any carbohydrate acid derivative anion obtained by deprotonation of at least one of the neuraminosyl carboxy groups of a ganglioside.
http://purl.obolibrary.org/obo/CHEBI_88071	monosialodiglycosylceramide(1-)	http://purl.obolibrary.org/obo/CHEBI_79346	anionic ganglioside		An anionic ganglioside in which the oligosaccharide portion is composed of a disaccharide, to which one sialic acid residue is attached.
http://purl.obolibrary.org/obo/CHEBI_68485	alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp	http://purl.obolibrary.org/obo/CHEBI_60948	alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc		α-<small>D</small>-Gal<em>p</em>-(1→4)-β-<small>D</small>-Gal<em>p</em>-(1→4)-<small>D</small>-Glc<em>p</em> with β-configuration at the reducing end anomeric centre.
http://purl.obolibrary.org/obo/CHEBI_68566	3-methylglutaric acid	http://purl.obolibrary.org/obo/CHEBI_28383	alpha,omega-dicarboxylic acid		An α,ω-dicarboxylic acid that is glutaric acid substituted at position 3 by a methyl group.
http://purl.obolibrary.org/obo/CHEBI_68641	(-)-cotinine	http://purl.obolibrary.org/obo/CHEBI_26456	pyrrolidine alkaloid		An <em>N</em>-alkylpyrrolidine that consists of <em>N</em>-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5<i>S</i>-enantiomer). It is an alkaloid commonly found in <em>Nicotiana tabacum</em>.
http://purl.obolibrary.org/obo/CHEBI_77268	pristanate	http://purl.obolibrary.org/obo/CHEBI_57560	long-chain fatty acid anion		A methyl-branched fatty acid anion that is the conjugate base of pristanic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_77968	humectant	http://purl.obolibrary.org/obo/CHEBI_33232	application		A compound that is used to keep a substance moist.
http://purl.obolibrary.org/obo/CHEBI_78123	fatty acid anion 16:0	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion containing 16 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_83976	2-methyl fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_67013	methyl-branched fatty acid anion		A methyl-branched fatty acid anion obtained by deprotonation of the carboxy group of any 2-methyl fatty acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CL_0000000	cell	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
http://purl.obolibrary.org/obo/CL_0000005	neural crest derived fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		Any fibroblast that is derived from the neural crest.
http://purl.obolibrary.org/obo/CL_0000006	neuronal receptor cell	http://purl.obolibrary.org/obo/CL_0000197	sensory receptor cell		Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception.
http://purl.obolibrary.org/obo/CL_0000007	early embryonic cell (metazoa)	http://purl.obolibrary.org/obo/CL_0002321	embryonic cell (metazoa)		A cell found in the embryo before the formation of all the germ layers is complete.
http://purl.obolibrary.org/obo/CL_0000008	migratory cranial neural crest cell	http://purl.obolibrary.org/obo/CL_0000333	migratory neural crest cell		Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.
http://purl.obolibrary.org/obo/CL_0000011	migratory trunk neural crest cell	http://purl.obolibrary.org/obo/CL_0000333	migratory neural crest cell		Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.
http://purl.obolibrary.org/obo/CL_0000014	germ line stem cell	http://purl.obolibrary.org/obo/CL_0000039	germ line cell		A stem cell that is the precursor of gametes.
http://purl.obolibrary.org/obo/CL_0000015	male germ cell	http://purl.obolibrary.org/obo/CL_0000586	germ cell		A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis.
http://purl.obolibrary.org/obo/CL_0000017	spermatocyte	http://purl.obolibrary.org/obo/CL_0000015	male germ cell		A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids.
http://purl.obolibrary.org/obo/CL_0000018	spermatid	http://purl.obolibrary.org/obo/CL_0000413	haploid cell		A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa.
http://purl.obolibrary.org/obo/CL_0000019	sperm	http://purl.obolibrary.org/obo/CL_0000408	male gamete		A mature male germ cell that develops from a spermatid.
http://purl.obolibrary.org/obo/CL_0000020	spermatogonium	http://purl.obolibrary.org/obo/CL_0000015	male germ cell		An euploid male germ cell of an early stage of spermatogenesis.
http://purl.obolibrary.org/obo/CL_0000021	female germ cell	http://purl.obolibrary.org/obo/CL_0000586	germ cell		Female germ cell is a germ cell that supports female gamete production.
http://purl.obolibrary.org/obo/CL_0000022	female germ line stem cell	http://purl.obolibrary.org/obo/CL_0000021	female germ cell		A stem cell that is the precursor of female gametes.
http://purl.obolibrary.org/obo/CL_0000023	oocyte	http://purl.obolibrary.org/obo/CL_0000021	female germ cell		A female germ cell that has entered meiosis.
http://purl.obolibrary.org/obo/CL_0000024	oogonial cell	http://purl.obolibrary.org/obo/CL_0000021	female germ cell		An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.
http://purl.obolibrary.org/obo/CL_0000027	smooth muscle cell neural crest derived	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell derived from the neural crest.
http://purl.obolibrary.org/obo/CL_0000029	neural crest derived neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		Any neuron that develops from some migratory neural crest cell.
http://purl.obolibrary.org/obo/CL_0000030	glioblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A non-terminally differentiated cell that develops from the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes.
http://purl.obolibrary.org/obo/CL_0000031	neuroblast (sensu Vertebrata)	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A cell that will develop into a neuron often after a migration phase.
http://purl.obolibrary.org/obo/CL_0000034	stem cell	http://purl.obolibrary.org/obo/CL_0011115	precursor cell		A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
http://purl.obolibrary.org/obo/CL_0000035	single fate stem cell	http://purl.obolibrary.org/obo/CL_0000723	somatic stem cell		A stem cell that self-renews as well as give rise to a single mature cell type.
http://purl.obolibrary.org/obo/CL_0000036	epithelial fate stem cell	http://purl.obolibrary.org/obo/CL_0000723	somatic stem cell		A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues.
http://purl.obolibrary.org/obo/CL_0000037	hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.
http://purl.obolibrary.org/obo/CL_0000038	erythroid progenitor cell	http://purl.obolibrary.org/obo/CL_0000839	myeloid lineage restricted progenitor cell		A progenitor cell committed to the erythroid lineage.
http://purl.obolibrary.org/obo/CL_0000039	germ line cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.
http://purl.obolibrary.org/obo/CL_0000040	monoblast	http://purl.obolibrary.org/obo/CL_0002194	monopoietic cell		A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.
http://purl.obolibrary.org/obo/CL_0000047	neural stem cell	http://purl.obolibrary.org/obo/CL_0002319	neural cell		An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types.
http://purl.obolibrary.org/obo/CL_0000048	multi fate stem cell	http://purl.obolibrary.org/obo/CL_0000034	stem cell		A stem cell that can give rise to multiple lineages of cells.
http://purl.obolibrary.org/obo/CL_0000049	common myeloid progenitor	http://purl.obolibrary.org/obo/CL_0002032	hematopoietic oligopotent progenitor cell		A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.
http://purl.obolibrary.org/obo/CL_0000050	megakaryocyte-erythroid progenitor cell	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A progenitor cell committed to the megakaryocyte and erythroid lineages.
http://purl.obolibrary.org/obo/CL_0000051	common lymphoid progenitor	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A oligopotent progenitor cell committed to the lymphoid lineage.
http://purl.obolibrary.org/obo/CL_0000052	totipotent stem cell	http://purl.obolibrary.org/obo/CL_0000723	somatic stem cell		A stem cell from which all cells of the body can form.
http://purl.obolibrary.org/obo/CL_0000056	myoblast	http://purl.obolibrary.org/obo/CL_0000680	muscle precursor cell		A cell that is committed to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair.
http://purl.obolibrary.org/obo/CL_0000057	fibroblast	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
http://purl.obolibrary.org/obo/CL_0000058	chondroblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.
http://purl.obolibrary.org/obo/CL_0000059	ameloblast	http://purl.obolibrary.org/obo/CL_0002077	ecto-epithelial cell		Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell.
http://purl.obolibrary.org/obo/CL_0000060	odontoblast	http://purl.obolibrary.org/obo/CL_0002148	dental pulp cell		Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell.
http://purl.obolibrary.org/obo/CL_0000064	ciliated cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell that has a filiform extrusion of the cell surface.
http://purl.obolibrary.org/obo/CL_0000066	epithelial cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
http://purl.obolibrary.org/obo/CL_0000067	ciliated epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that has a cilia.
http://purl.obolibrary.org/obo/CL_0000068	duct epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that is part of a duct.
http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell	http://purl.obolibrary.org/obo/CL_0002139	endothelial cell of vascular tree		An endothelial cell that lines the vasculature.
http://purl.obolibrary.org/obo/CL_0000075	columnar/cuboidal epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
http://purl.obolibrary.org/obo/CL_0000076	squamous epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that has a flattened morphology.
http://purl.obolibrary.org/obo/CL_0000077	mesothelial cell	http://purl.obolibrary.org/obo/CL_0002078	meso-epithelial cell		A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement.
http://purl.obolibrary.org/obo/CL_0000078	peridermal cell	http://purl.obolibrary.org/obo/CL_0000362	epidermal cell		Any squamous epithelial cell that is part of some periderm.
http://purl.obolibrary.org/obo/CL_0000079	stratified epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane.
http://purl.obolibrary.org/obo/CL_0000080	circulating cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell which moves among different tissues of the body, via blood, lymph, or other medium.
http://purl.obolibrary.org/obo/CL_0000081	blood cell	http://purl.obolibrary.org/obo/CL_0000988	hematopoietic cell		A cell found predominately in the blood.
http://purl.obolibrary.org/obo/CL_0000082	epithelial cell of lung	http://purl.obolibrary.org/obo/CL_0002632	epithelial cell of lower respiratory tract		An epithelial cell of the lung.
http://purl.obolibrary.org/obo/CL_0000083	epithelial cell of pancreas	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An epithelial cell of the pancreas.
http://purl.obolibrary.org/obo/CL_0000084	T cell	http://purl.obolibrary.org/obo/CL_0000542	lymphocyte		A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
http://purl.obolibrary.org/obo/CL_0000094	granulocyte	http://purl.obolibrary.org/obo/CL_0000766	myeloid leukocyte		A leukocyte with abundant granules in the cytoplasm.
http://purl.obolibrary.org/obo/CL_0000097	mast cell	http://purl.obolibrary.org/obo/CL_0002274	histamine secreting cell		A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
http://purl.obolibrary.org/obo/CL_0000098	sensory epithelial cell	http://purl.obolibrary.org/obo/CL_0000197	sensory receptor cell		A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.
http://purl.obolibrary.org/obo/CL_0000099	interneuron	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.
http://purl.obolibrary.org/obo/CL_0000100	motor neuron	http://purl.obolibrary.org/obo/CL_0000527	efferent neuron		An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.
http://purl.obolibrary.org/obo/CL_0000101	sensory neuron	http://purl.obolibrary.org/obo/CL_0000526	afferent neuron		Any neuron having a sensory function; an afferent neuron conveying sensory impulses.
http://purl.obolibrary.org/obo/CL_0000107	autonomic neuron	http://purl.obolibrary.org/obo/CL_2000032	peripheral nervous system neuron		A neuron whose cell body is within an autonomic ganglion.
http://purl.obolibrary.org/obo/CL_0000108	cholinergic neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		A neuron that uses acetylcholine as a vesicular neurotransmitter.
http://purl.obolibrary.org/obo/CL_0000113	mononuclear phagocyte	http://purl.obolibrary.org/obo/CL_0000842	mononuclear leukocyte		A vertebrate phagocyte with a single nucleus.
http://purl.obolibrary.org/obo/CL_0000114	surface ectodermal cell	http://purl.obolibrary.org/obo/CL_0000221	ectodermal cell		An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024).
http://purl.obolibrary.org/obo/CL_0000115	endothelial cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.
http://purl.obolibrary.org/obo/CL_0000118	basket cell	http://purl.obolibrary.org/obo/CL_0011005	GABAergic interneuron		Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells.
http://purl.obolibrary.org/obo/CL_0000119	cerebellar Golgi cell	http://purl.obolibrary.org/obo/CL_4023057	cerebellar inhibitory GABAergic interneuron		Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004.
http://purl.obolibrary.org/obo/CL_0000120	granule cell	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb.
http://purl.obolibrary.org/obo/CL_0000121	Purkinje cell	http://purl.obolibrary.org/obo/CL_1001611	cerebellar neuron		An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as "simple spikes," and climbing fibres, which modulate infrequent calcium spike activity known as "complex spikes". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress.
http://purl.obolibrary.org/obo/CL_0000122	stellate neuron	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A neuron that has dendritic processes radiating from the cell body forming a star-like shape.
http://purl.obolibrary.org/obo/CL_0000125	glial cell	http://purl.obolibrary.org/obo/CL_0000095	neuron associated cell		A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
http://purl.obolibrary.org/obo/CL_0000126	macroglial cell	http://purl.obolibrary.org/obo/CL_0000125	glial cell		A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.
http://purl.obolibrary.org/obo/CL_0000127	astrocyte	http://purl.obolibrary.org/obo/CL_0000126	macroglial cell		A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.
http://purl.obolibrary.org/obo/CL_0000128	oligodendrocyte	http://purl.obolibrary.org/obo/CL_4023154	myelinating glial cell		A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.
http://purl.obolibrary.org/obo/CL_0000129	microglial cell	http://purl.obolibrary.org/obo/CL_0000878	central nervous system macrophage		A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.
http://purl.obolibrary.org/obo/CL_0000131	gut endothelial cell	http://purl.obolibrary.org/obo/CL_0000115	endothelial cell		An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream.
http://purl.obolibrary.org/obo/CL_0000133	neurectodermal cell	http://purl.obolibrary.org/obo/CL_0000221	ectodermal cell		Ectoderm destined to be nervous tissue.
http://purl.obolibrary.org/obo/CL_0000134	mesenchymal stem cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.
http://purl.obolibrary.org/obo/CL_0000136	adipocyte	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.
http://purl.obolibrary.org/obo/CL_0000138	chondrocyte	http://purl.obolibrary.org/obo/CL_0007001	skeletogenic cell		A skeletogenic cell that secretes a specialized, avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.
http://purl.obolibrary.org/obo/CL_0000145	professional antigen presenting cell	http://purl.obolibrary.org/obo/CL_0000738	leukocyte		A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.
http://purl.obolibrary.org/obo/CL_0000147	pigment cell	http://purl.obolibrary.org/obo/CL_0000325	stuff accumulating cell		A pigment cell is a cell that contains pigment granules.
http://purl.obolibrary.org/obo/CL_0000148	melanocyte	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.
http://purl.obolibrary.org/obo/CL_0000150	glandular secretory epithelial cell	http://purl.obolibrary.org/obo/CL_1100001	secretory epithelial cell		An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous.
http://purl.obolibrary.org/obo/CL_0000151	secretory cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that specializes in controlled release of one or more substances.
http://purl.obolibrary.org/obo/CL_0000152	exocrine cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.
http://purl.obolibrary.org/obo/CL_0000153	glycosaminoglycan secreting cell	http://purl.obolibrary.org/obo/CL_0000447	carbohydrate secreting cell		A cell that secretes glycosaminoglycans.
http://purl.obolibrary.org/obo/CL_0000154	protein secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		Any secretory cell that is capable of some protein secretion.
http://purl.obolibrary.org/obo/CL_0000157	surfactant secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		A cell that specializes in secretion of surfactant in the alveoli of the lung.
http://purl.obolibrary.org/obo/CL_0000158	club cell	http://purl.obolibrary.org/obo/CL_0008055	respiratory tract secretory epithelial cell		A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium.
http://purl.obolibrary.org/obo/CL_0000160	goblet cell	http://purl.obolibrary.org/obo/CL_0000319	mucus secreting cell		A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules.  Short microvilli project from the apical plasma membrane.
http://purl.obolibrary.org/obo/CL_0000163	endocrine cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
http://purl.obolibrary.org/obo/CL_0000164	enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0000163	endocrine cell		An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.
http://purl.obolibrary.org/obo/CL_0000165	neuroendocrine cell	http://purl.obolibrary.org/obo/CL_0000710	neurecto-epithelial cell		A neuron that is capable of some hormone secretion in response to neuronal signals.
http://purl.obolibrary.org/obo/CL_0000166	chromaffin cell	http://purl.obolibrary.org/obo/CL_0000568	amine precursor uptake and decarboxylation cell		A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system.
http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		Any secretory cell that is capable of some peptide hormone secretion.
http://purl.obolibrary.org/obo/CL_0000168	insulin secreting cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any secretory cell that is capable of some insulin secretion.
http://purl.obolibrary.org/obo/CL_0000169	type B pancreatic cell	http://purl.obolibrary.org/obo/CL_0008024	pancreatic endocrine cell		A cell that secretes insulin and is located towards the center of the islets of Langerhans.
http://purl.obolibrary.org/obo/CL_0000170	glucagon secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A cell that secretes glucagon.
http://purl.obolibrary.org/obo/CL_0000171	pancreatic A cell	http://purl.obolibrary.org/obo/CL_0008024	pancreatic endocrine cell		A type A enteroendocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.
http://purl.obolibrary.org/obo/CL_0000172	somatostatin secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		Any secretory cell that is capable of some somatostatin secretion.
http://purl.obolibrary.org/obo/CL_0000173	pancreatic D cell	http://purl.obolibrary.org/obo/CL_0008024	pancreatic endocrine cell		A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.
http://purl.obolibrary.org/obo/CL_0000174	steroid hormone secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		Any secretory cell that is capable of some steroid hormone secretion.
http://purl.obolibrary.org/obo/CL_0000177	testosterone secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		Any secretory cell that is capable of some testosterone secretion.
http://purl.obolibrary.org/obo/CL_0000178	Leydig cell	http://purl.obolibrary.org/obo/CL_0000177	testosterone secreting cell		A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.
http://purl.obolibrary.org/obo/CL_0000182	hepatocyte	http://purl.obolibrary.org/obo/CL_0000417	endopolyploid cell		The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.
http://purl.obolibrary.org/obo/CL_0000183	contractile cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell whose primary function is to shorten.
http://purl.obolibrary.org/obo/CL_0000187	muscle cell	http://purl.obolibrary.org/obo/CL_0000393	electrically responsive cell		A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
http://purl.obolibrary.org/obo/CL_0000188	cell of skeletal muscle	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A somatic cell located in skeletal muscle.
http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell	http://purl.obolibrary.org/obo/CL_0008007	visceral muscle cell		A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).
http://purl.obolibrary.org/obo/CL_0000197	sensory receptor cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell that is capable of detection of a stimulus involved in sensory perception.
http://purl.obolibrary.org/obo/CL_0000199	mechanoreceptor cell	http://purl.obolibrary.org/obo/CL_0000101	sensory neuron		A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system.
http://purl.obolibrary.org/obo/CL_0000200	touch receptor cell	http://purl.obolibrary.org/obo/CL_0000199	mechanoreceptor cell		Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception of touch.
http://purl.obolibrary.org/obo/CL_0000203	gravity sensitive cell	http://purl.obolibrary.org/obo/CL_0000199	mechanoreceptor cell		Any neuronal receptor cell that is capable of some detection of mechanical stimulus involved in sensory perception.
http://purl.obolibrary.org/obo/CL_0000206	chemoreceptor cell	http://purl.obolibrary.org/obo/CL_0000197	sensory receptor cell		A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.
http://purl.obolibrary.org/obo/CL_0000207	olfactory receptor cell	http://purl.obolibrary.org/obo/CL_0000206	chemoreceptor cell		Any neuron that is capable of some detection of chemical stimulus involved in sensory perception of smell.
http://purl.obolibrary.org/obo/CL_0000209	taste receptor cell	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		A specialized cell involved in gustatory sensory perception.
http://purl.obolibrary.org/obo/CL_0000210	photoreceptor cell	http://purl.obolibrary.org/obo/CL_0000101	sensory neuron		A cell specialized in detecting light stimuli that are involved in visual perception.
http://purl.obolibrary.org/obo/CL_0000211	electrically active cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell whose function is determined by the generation or the reception of an electric signal.
http://purl.obolibrary.org/obo/CL_0000214	synovial cell	http://purl.obolibrary.org/obo/CL_0002078	meso-epithelial cell		A cell located in the synovial joint.
http://purl.obolibrary.org/obo/CL_0000216	Sertoli cell	http://purl.obolibrary.org/obo/CL_0002625	seminiferous tubule epithelial cell		A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier.
http://purl.obolibrary.org/obo/CL_0000219	motile cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that moves by its own activities.
http://purl.obolibrary.org/obo/CL_0000221	ectodermal cell	http://purl.obolibrary.org/obo/CL_0002321	embryonic cell (metazoa)		A cell of the outer of the three germ layers of the embryo.
http://purl.obolibrary.org/obo/CL_0000222	mesodermal cell	http://purl.obolibrary.org/obo/CL_0002321	embryonic cell (metazoa)		A cell of the middle germ layer of the embryo.
http://purl.obolibrary.org/obo/CL_0000223	endodermal cell	http://purl.obolibrary.org/obo/CL_0002321	embryonic cell (metazoa)		A cell of the inner of the three germ layers of the embryo.
http://purl.obolibrary.org/obo/CL_0000225	anucleate cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that lacks a nucleus.
http://purl.obolibrary.org/obo/CL_0000226	single nucleate cell	http://purl.obolibrary.org/obo/CL_0002242	nucleate cell		A cell with a single nucleus.
http://purl.obolibrary.org/obo/CL_0000228	multinucleate cell	http://purl.obolibrary.org/obo/CL_0002242	nucleate cell		A cell with more than one nucleus.
http://purl.obolibrary.org/obo/CL_0000232	erythrocyte	http://purl.obolibrary.org/obo/CL_0000764	erythroid lineage cell		A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.
http://purl.obolibrary.org/obo/CL_0000233	platelet	http://purl.obolibrary.org/obo/CL_0000763	myeloid cell		A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
http://purl.obolibrary.org/obo/CL_0000234	phagocyte	http://purl.obolibrary.org/obo/CL_0000325	stuff accumulating cell		Any cell capable of ingesting particulate matter via phagocytosis.
http://purl.obolibrary.org/obo/CL_0000235	macrophage	http://purl.obolibrary.org/obo/CL_0000766	myeloid leukocyte		A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
http://purl.obolibrary.org/obo/CL_0000236	B cell	http://purl.obolibrary.org/obo/CL_0000945	lymphocyte of B lineage		A lymphocyte of B lineage that is capable of B cell mediated immunity.
http://purl.obolibrary.org/obo/CL_0000240	stratified squamous epithelial cell	http://purl.obolibrary.org/obo/CL_0000079	stratified epithelial cell		A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus.
http://purl.obolibrary.org/obo/CL_0000241	stratified cuboidal epithelial cell	http://purl.obolibrary.org/obo/CL_0000079	stratified epithelial cell		A stratified epithelial cell that is part of cuboidal epithelium, characterized by multiple layers of cuboidal cells forming the apical layer. This provides a protective lining for ducts in large glands, such as sweat glands.
http://purl.obolibrary.org/obo/CL_0000242	Merkel cell	http://purl.obolibrary.org/obo/CL_0000710	neurecto-epithelial cell		A specialized epithelial cell located in the skin epidermis and certain mucosal epithelia. It functions as a mechanoreceptor for light touch by forming synapse-like contacts with somatosensory afferent nerve endings, contributing to slowly adapting type I (SAI) tactile responses. Characterized by dense-core neuroendocrine granules, the Merkel cell exhibits both sensory and neuroendocrine properties, including regulated neurotransmitter release via SNARE complex-dependent mechanisms. Its development in mice depends on the transcription factor Atoh1.
http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell	http://purl.obolibrary.org/obo/CL_0000000	cell		Any cell that in taxon some Eukaryota.
http://purl.obolibrary.org/obo/CL_0000287	eye photoreceptor cell	http://purl.obolibrary.org/obo/CL_0000210	photoreceptor cell		Any photoreceptor cell that is part of some eye.
http://purl.obolibrary.org/obo/CL_0000295	somatotropin secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A peptide hormone secreting cell that produces growth hormone, somatotropin.
http://purl.obolibrary.org/obo/CL_0000300	gamete	http://purl.obolibrary.org/obo/CL_0000586	germ cell		A mature sexual reproductive cell having a single set of unpaired chromosomes.
http://purl.obolibrary.org/obo/CL_0000307	tracheal epithelial cell	http://purl.obolibrary.org/obo/CL_0002202	epithelial cell of tracheobronchial tree		An epithelial cell found in the trachea.
http://purl.obolibrary.org/obo/CL_0000312	keratinocyte	http://purl.obolibrary.org/obo/CL_0000237	keratinizing barrier epithelial cell		An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense.
http://purl.obolibrary.org/obo/CL_0000313	serous secreting cell	http://purl.obolibrary.org/obo/CL_0000159	seromucus secreting cell		Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.
http://purl.obolibrary.org/obo/CL_0000317	sebocyte	http://purl.obolibrary.org/obo/CL_2000021	sebaceous gland cell		An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents.
http://purl.obolibrary.org/obo/CL_0000319	mucus secreting cell	http://purl.obolibrary.org/obo/CL_0000159	seromucus secreting cell		Any cell that is capable of some mucus secretion.
http://purl.obolibrary.org/obo/CL_0000322	pulmonary alveolar epithelial cell	http://purl.obolibrary.org/obo/CL_0000082	epithelial cell of lung		An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.
http://purl.obolibrary.org/obo/CL_0000325	stuff accumulating cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that is specialised to accumulate a particular substance(s).
http://purl.obolibrary.org/obo/CL_0000329	oxygen accumulating cell	http://purl.obolibrary.org/obo/CL_0000000	cell		Any cell that is capable of some oxygen transport.
http://purl.obolibrary.org/obo/CL_0000333	migratory neural crest cell	http://purl.obolibrary.org/obo/CL_0011012	neural crest cell		A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.
http://purl.obolibrary.org/obo/CL_0000335	mesenchyme condensation cell	http://purl.obolibrary.org/obo/CL_0008019	mesenchymal cell		A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.
http://purl.obolibrary.org/obo/CL_0000336	adrenal medulla chromaffin cell	http://purl.obolibrary.org/obo/CL_1000426	chromaffin cell of adrenal gland		A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation.
http://purl.obolibrary.org/obo/CL_0000339	glioblast (sensu Vertebrata)	http://purl.obolibrary.org/obo/CL_0000123	neuron associated cell (sensu Vertebrata)		An early neural cell developing from the early ependymal cell of the neural tube.
http://purl.obolibrary.org/obo/CL_0000347	scleral cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell of the sclera of the eye.
http://purl.obolibrary.org/obo/CL_0000348	choroidal cell of the eye	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell that is part of optic choroid.
http://purl.obolibrary.org/obo/CL_0000349	extraembryonic cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any cell that is part of some extraembryonic structure.
http://purl.obolibrary.org/obo/CL_0000351	trophoblast cell	http://purl.obolibrary.org/obo/CL_0000349	extraembryonic cell		An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development.
http://purl.obolibrary.org/obo/CL_0000352	epiblast cell	http://purl.obolibrary.org/obo/CL_0000052	totipotent stem cell		A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.
http://purl.obolibrary.org/obo/CL_0000353	blastoderm cell	http://purl.obolibrary.org/obo/CL_0000007	early embryonic cell (metazoa)		An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).
http://purl.obolibrary.org/obo/CL_0000355	multi-potent skeletal muscle stem cell	http://purl.obolibrary.org/obo/CL_0000188	cell of skeletal muscle		A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.
http://purl.obolibrary.org/obo/CL_0000358	sphincter associated smooth muscle cell	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.
http://purl.obolibrary.org/obo/CL_0000359	vascular associated smooth muscle cell	http://purl.obolibrary.org/obo/CL_4033054	perivascular cell		A smooth muscle cell associated with the vasculature.
http://purl.obolibrary.org/obo/CL_0000362	epidermal cell	http://purl.obolibrary.org/obo/CL_0002159	general ecto-epithelial cell		An epithelial cell of the integument (the outer layer of an organism).
http://purl.obolibrary.org/obo/CL_0000365	animal zygote	http://purl.obolibrary.org/obo/CL_0010017	zygote		Diploid cell produced by the fusion of sperm cell nucleus and egg cell.
http://purl.obolibrary.org/obo/CL_0000393	electrically responsive cell	http://purl.obolibrary.org/obo/CL_0000211	electrically active cell		A cell whose function is determined by its response to an electric signal.
http://purl.obolibrary.org/obo/CL_0000397	ganglion interneuron	http://purl.obolibrary.org/obo/CL_0000099	interneuron		Any interneuron that has its soma located in some ganglion.
http://purl.obolibrary.org/obo/CL_0000404	electrically signaling cell	http://purl.obolibrary.org/obo/CL_0000211	electrically active cell		A cell that initiates an electrical signal and passes that signal to another cell.
http://purl.obolibrary.org/obo/CL_0000408	male gamete	http://purl.obolibrary.org/obo/CL_0000300	gamete		Any male germ cell that has characteristic some haploid and is capable of some fertilization.
http://purl.obolibrary.org/obo/CL_0000412	polyploid cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that contains more than two haploid sets of chromosomes.
http://purl.obolibrary.org/obo/CL_0000413	haploid cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell whose nucleus contains a single haploid genome.
http://purl.obolibrary.org/obo/CL_0000432	reticular cell	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain.
http://purl.obolibrary.org/obo/CL_0000438	luteinizing hormone secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		A peptide hormone secreting cell pituitary that produces luteinizing hormone.
http://purl.obolibrary.org/obo/CL_0000439	prolactin secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A peptide hormone cell that secretes prolactin.
http://purl.obolibrary.org/obo/CL_0000440	melanocyte stimulating hormone secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A cell of the intermediate pituitary that produces melanocyte stimulating hormone.
http://purl.obolibrary.org/obo/CL_0000443	calcitonin secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		Any secretory cell that is capable of some calcitonin secretion.
http://purl.obolibrary.org/obo/CL_0000446	chief cell of parathyroid gland	http://purl.obolibrary.org/obo/CL_1001593	parathyroid glandular cell		An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone.
http://purl.obolibrary.org/obo/CL_0000451	dendritic cell	http://purl.obolibrary.org/obo/CL_0000145	professional antigen presenting cell		A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).
http://purl.obolibrary.org/obo/CL_0000453	Langerhans cell	http://purl.obolibrary.org/obo/CL_0000990	conventional dendritic cell		Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.
http://purl.obolibrary.org/obo/CL_0000454	epinephrine secreting cell	http://purl.obolibrary.org/obo/CL_0000457	biogenic amine secreting cell		A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types.
http://purl.obolibrary.org/obo/CL_0000456	mineralocorticoid secreting cell	http://purl.obolibrary.org/obo/CL_0000174	steroid hormone secreting cell		Any secretory cell that is capable of some mineralocorticoid secretion.
http://purl.obolibrary.org/obo/CL_0000458	serotonin secreting cell	http://purl.obolibrary.org/obo/CL_0000457	biogenic amine secreting cell		A cell type that secretes 5-Hydroxytryptamine (serotonin).
http://purl.obolibrary.org/obo/CL_0000459	noradrenergic cell	http://purl.obolibrary.org/obo/CL_0000457	biogenic amine secreting cell		A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.
http://purl.obolibrary.org/obo/CL_0000467	adrenocorticotropic hormone secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin.
http://purl.obolibrary.org/obo/CL_0000484	connective tissue type mast cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent.
http://purl.obolibrary.org/obo/CL_0000488	visible light photoreceptor cell	http://purl.obolibrary.org/obo/CL_0000210	photoreceptor cell		A photoreceptor cell that detects visible light.
http://purl.obolibrary.org/obo/CL_0000492	CD4-positive helper T cell	http://purl.obolibrary.org/obo/CL_0000624	CD4-positive, alpha-beta T cell		A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions.
http://purl.obolibrary.org/obo/CL_0000498	inhibitory interneuron	http://purl.obolibrary.org/obo/CL_0000099	interneuron		An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS).
http://purl.obolibrary.org/obo/CL_0000499	stromal cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A connective tissue cell of an organ found in the loose connective tissue.
http://purl.obolibrary.org/obo/CL_0000502	type D enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0000172	somatostatin secreting cell		A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.
http://purl.obolibrary.org/obo/CL_0000506	enkephalin secreting cell	http://purl.obolibrary.org/obo/CL_0000507	endorphin secreting cell		An endorphine cell that secretes enkephalin.
http://purl.obolibrary.org/obo/CL_0000507	endorphin secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A peptide hormone secreting cell that secretes endorphin.
http://purl.obolibrary.org/obo/CL_0000508	type G enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0000509	gastrin secreting cell		An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.
http://purl.obolibrary.org/obo/CL_0000509	gastrin secreting cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A peptide hormone secreting cell that secretes gastrin.
http://purl.obolibrary.org/obo/CL_0000511	androgen binding protein secreting cell	http://purl.obolibrary.org/obo/CL_0000154	protein secreting cell		A peptide hormone secreting cell that secretes androgen binding protein.
http://purl.obolibrary.org/obo/CL_0000513	cardiac muscle myoblast	http://purl.obolibrary.org/obo/CL_0010021	cardiac myoblast		A precursor cell destined to differentiate into cardiac muscle cell.
http://purl.obolibrary.org/obo/CL_0000514	smooth muscle myoblast	http://purl.obolibrary.org/obo/CL_0000056	myoblast		A precursor cell destined to differentiate into smooth muscle myocytes.
http://purl.obolibrary.org/obo/CL_0000515	skeletal muscle myoblast	http://purl.obolibrary.org/obo/CL_0000056	myoblast		A myoblast that differentiates into skeletal muscle fibers.
http://purl.obolibrary.org/obo/CL_0000518	phagocyte (sensu Vertebrata)	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A phagocyte in vertebrates that is able to phagocytosis.
http://purl.obolibrary.org/obo/CL_0000525	syncytiotrophoblast cell	http://purl.obolibrary.org/obo/CL_0000351	trophoblast cell		A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.
http://purl.obolibrary.org/obo/CL_0000526	afferent neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		A neuron which conveys sensory information centrally from the periphery.
http://purl.obolibrary.org/obo/CL_0000527	efferent neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		A neuron which sends impulses peripherally to activate muscles or secretory cells.
http://purl.obolibrary.org/obo/CL_0000540	neuron	http://purl.obolibrary.org/obo/CL_0002319	neural cell		The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
http://purl.obolibrary.org/obo/CL_0000541	melanoblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A cell that originates from the neural crest and differentiates into a pigment cell.
http://purl.obolibrary.org/obo/CL_0000542	lymphocyte	http://purl.obolibrary.org/obo/CL_0000842	mononuclear leukocyte		A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
http://purl.obolibrary.org/obo/CL_0000547	proerythroblast	http://purl.obolibrary.org/obo/CL_0002242	nucleate cell		An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.
http://purl.obolibrary.org/obo/CL_0000549	basophilic erythroblast	http://purl.obolibrary.org/obo/CL_0000765	erythroblast		A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.
http://purl.obolibrary.org/obo/CL_0000550	polychromatophilic erythroblast	http://purl.obolibrary.org/obo/CL_0000765	erythroblast		A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.
http://purl.obolibrary.org/obo/CL_0000552	orthochromatic erythroblast	http://purl.obolibrary.org/obo/CL_0000765	erythroblast		The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.
http://purl.obolibrary.org/obo/CL_0000553	megakaryocyte progenitor cell	http://purl.obolibrary.org/obo/CL_0000839	myeloid lineage restricted progenitor cell		The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).
http://purl.obolibrary.org/obo/CL_0000556	megakaryocyte	http://purl.obolibrary.org/obo/CL_0000763	myeloid cell		A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.
http://purl.obolibrary.org/obo/CL_0000557	granulocyte monocyte progenitor cell	http://purl.obolibrary.org/obo/CL_1001610	bone marrow hematopoietic cell		A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.
http://purl.obolibrary.org/obo/CL_0000558	reticulocyte	http://purl.obolibrary.org/obo/CL_0000764	erythroid lineage cell		An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.
http://purl.obolibrary.org/obo/CL_0000559	promonocyte	http://purl.obolibrary.org/obo/CL_0002194	monopoietic cell		A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.
http://purl.obolibrary.org/obo/CL_0000561	amacrine cell	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons.
http://purl.obolibrary.org/obo/CL_0000562	nucleate erythrocyte	http://purl.obolibrary.org/obo/CL_0002242	nucleate cell		An erythrocyte having a nucleus.
http://purl.obolibrary.org/obo/CL_0000566	angioblastic mesenchymal cell	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A mesenchymal stem cell capable of developing into blood vessel endothelium.
http://purl.obolibrary.org/obo/CL_0000568	amine precursor uptake and decarboxylation cell	http://purl.obolibrary.org/obo/CL_0000165	neuroendocrine cell		A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell.
http://purl.obolibrary.org/obo/CL_0000569	cardiac mesenchymal cell	http://purl.obolibrary.org/obo/CL_2000073	migratory cardiac neural crest cell		A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.
http://purl.obolibrary.org/obo/CL_0000570	parafollicular cell	http://purl.obolibrary.org/obo/CL_0002257	epithelial cell of thyroid gland		A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. This cell expresses a form of the neural cell adhesion molecule (N-CAM) on its surface and secretes calcitonin and serotonin (5-hydroxytryptamine).
http://purl.obolibrary.org/obo/CL_0000573	retinal cone cell	http://purl.obolibrary.org/obo/CL_0010009	camera-type eye photoreceptor cell		One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.
http://purl.obolibrary.org/obo/CL_0000575	corneal epithelial cell	http://purl.obolibrary.org/obo/CL_0002159	general ecto-epithelial cell		An epithelial cell of the cornea.
http://purl.obolibrary.org/obo/CL_0000576	monocyte	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
http://purl.obolibrary.org/obo/CL_0000586	germ cell	http://purl.obolibrary.org/obo/CL_0000039	germ line cell		The reproductive cell in multicellular organisms.
http://purl.obolibrary.org/obo/CL_0000593	androgen secreting cell	http://purl.obolibrary.org/obo/CL_0000174	steroid hormone secreting cell		A steroid hormone secreting cell that secretes androgen.
http://purl.obolibrary.org/obo/CL_0000595	enucleate erythrocyte	http://purl.obolibrary.org/obo/CL_0000232	erythrocyte		An erythrocyte lacking a nucleus.
http://purl.obolibrary.org/obo/CL_0000604	retinal rod cell	http://purl.obolibrary.org/obo/CL_0010009	camera-type eye photoreceptor cell		One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.
http://purl.obolibrary.org/obo/CL_0000613	basophil progenitor cell	http://purl.obolibrary.org/obo/CL_0002191	granulocytopoietic cell		A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa.
http://purl.obolibrary.org/obo/CL_0000617	GABAergic neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		A neuron that uses GABA as a vesicular neurotransmitter
http://purl.obolibrary.org/obo/CL_0000622	acinar cell	http://purl.obolibrary.org/obo/CL_0000154	protein secreting cell		A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).
http://purl.obolibrary.org/obo/CL_0000623	natural killer cell	http://purl.obolibrary.org/obo/CL_0001067	group 1 innate lymphoid cell		A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
http://purl.obolibrary.org/obo/CL_0000624	CD4-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000791	mature alpha-beta T cell		A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor.
http://purl.obolibrary.org/obo/CL_0000625	CD8-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000791	mature alpha-beta T cell		A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor.
http://purl.obolibrary.org/obo/CL_0000626	olfactory granule cell	http://purl.obolibrary.org/obo/CL_1001434	olfactory bulb interneuron		A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors.
http://purl.obolibrary.org/obo/CL_0000630	supporting cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell whose primary function is to support other cell types.
http://purl.obolibrary.org/obo/CL_0000632	hepatic stellate cell	http://purl.obolibrary.org/obo/CL_0000327	extracellular matrix secreting cell		A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver.
http://purl.obolibrary.org/obo/CL_0000636	Mueller cell	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer.
http://purl.obolibrary.org/obo/CL_0000637	chromophil cell of anterior pituitary gland	http://purl.obolibrary.org/obo/CL_2000004	pituitary gland cell		A cell that stains readily in the anterior pituitary gland.
http://purl.obolibrary.org/obo/CL_0000638	acidophil cell of pars distalis of adenohypophysis	http://purl.obolibrary.org/obo/CL_0000637	chromophil cell of anterior pituitary gland		An acidophilic chromophil cell that of the anterior pituitary gland.
http://purl.obolibrary.org/obo/CL_0000642	folliculostellate cell	http://purl.obolibrary.org/obo/CL_2000004	pituitary gland cell		An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions.
http://purl.obolibrary.org/obo/CL_0000646	basal cell	http://purl.obolibrary.org/obo/CL_0000036	epithelial fate stem cell		Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament.
http://purl.obolibrary.org/obo/CL_0000649	spinous cell of epidermis	http://purl.obolibrary.org/obo/CL_4052061	epidermal keratinocyte		A keratinocyte found within the stratum spinosum (prickle cell layer) of the epidermis, distinguished by numerous intercellular desmosomes, which give it a “prickly” or spiny appearance. Positioned above the mitotically active basal layer and beneath the granular layer, it contributes to the skin’s mechanical strength and barrier function, preventing water loss and pathogen entry. This cell expresses differentiation-specific keratins K1 and K10 in mice, unlike basal cells that express K5 and K14, and lacks the keratohyalin granules found in granular cells, marking its intermediate stage of epidermal differentiation.
http://purl.obolibrary.org/obo/CL_0000650	mesangial cell	http://purl.obolibrary.org/obo/CL_1001318	renal interstitial pericyte		A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries.
http://purl.obolibrary.org/obo/CL_0000652	pinealocyte	http://purl.obolibrary.org/obo/CL_0002319	neural cell		This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation.
http://purl.obolibrary.org/obo/CL_0000654	primary oocyte	http://purl.obolibrary.org/obo/CL_0000023	oocyte		A primary oocyte is an oocyte that has not completed female meosis I.
http://purl.obolibrary.org/obo/CL_0000655	secondary oocyte	http://purl.obolibrary.org/obo/CL_0000023	oocyte		A secondary oocyte is an oocyte that has not completed meiosis II.
http://purl.obolibrary.org/obo/CL_0000656	primary spermatocyte	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes.
http://purl.obolibrary.org/obo/CL_0000657	secondary spermatocyte	http://purl.obolibrary.org/obo/CL_0000413	haploid cell		One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids.
http://purl.obolibrary.org/obo/CL_0000666	fenestrated endothelial cell	http://purl.obolibrary.org/obo/CL_0000115	endothelial cell		An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues.
http://purl.obolibrary.org/obo/CL_0000667	collagen secreting cell	http://purl.obolibrary.org/obo/CL_0000327	extracellular matrix secreting cell		An extracellular matrix secreting cell that secretes collagen.
http://purl.obolibrary.org/obo/CL_0000669	pericyte	http://purl.obolibrary.org/obo/CL_0008034	mural cell		An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.
http://purl.obolibrary.org/obo/CL_0000670	primordial germ cell	http://purl.obolibrary.org/obo/CL_0000219	motile cell		A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.
http://purl.obolibrary.org/obo/CL_0000679	glutamatergic neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		A neuron that is capable of some neurotansmission by glutamate secretion.
http://purl.obolibrary.org/obo/CL_0000680	muscle precursor cell	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A non-terminally differentiated cell that is capable of developing into a muscle cell.
http://purl.obolibrary.org/obo/CL_0000681	radial glial cell	http://purl.obolibrary.org/obo/CL_0000125	glial cell		A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration.
http://purl.obolibrary.org/obo/CL_0000691	stellate interneuron	http://purl.obolibrary.org/obo/CL_0000122	stellate neuron		Any interneuron that has characteristic some stellate morphology.
http://purl.obolibrary.org/obo/CL_0000696	PP cell	http://purl.obolibrary.org/obo/CL_0000167	peptide hormone secreting cell		A cell that stores and secretes pancreatic polypeptide hormone.
http://purl.obolibrary.org/obo/CL_0000710	neurecto-epithelial cell	http://purl.obolibrary.org/obo/CL_0002077	ecto-epithelial cell		Epithelial cells derived from neural plate and neural crest.
http://purl.obolibrary.org/obo/CL_0000712	stratum granulosum cell	http://purl.obolibrary.org/obo/CL_0000362	epidermal cell		Any epidermal cell that is part of some stratum granulosum of epidermis.
http://purl.obolibrary.org/obo/CL_0000723	somatic stem cell	http://purl.obolibrary.org/obo/CL_0000034	stem cell		A stem cell that can give rise to cell types of the body other than those of the germ-line.
http://purl.obolibrary.org/obo/CL_0000737	striated muscle cell	http://purl.obolibrary.org/obo/CL_0000187	muscle cell		Muscle cell which has as its direct parts myofilaments organized into sarcomeres.
http://purl.obolibrary.org/obo/CL_0000738	leukocyte	http://purl.obolibrary.org/obo/CL_0002242	nucleate cell		An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
http://purl.obolibrary.org/obo/CL_0000740	retinal ganglion cell	http://purl.obolibrary.org/obo/CL_0000540	neuron		The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.
http://purl.obolibrary.org/obo/CL_0000745	retina horizontal cell	http://purl.obolibrary.org/obo/CL_0000099	interneuron		A neuron that laterally connects other neurons in the inner nuclear layer of the retina.
http://purl.obolibrary.org/obo/CL_0000746	cardiac muscle cell	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.
http://purl.obolibrary.org/obo/CL_0000748	retinal bipolar neuron	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.
http://purl.obolibrary.org/obo/CL_0000752	cone retinal bipolar cell	http://purl.obolibrary.org/obo/CL_0000748	retinal bipolar neuron		A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer.
http://purl.obolibrary.org/obo/CL_0000762	nucleated thrombocyte	http://purl.obolibrary.org/obo/CL_0000763	myeloid cell		A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates.
http://purl.obolibrary.org/obo/CL_0000763	myeloid cell	http://purl.obolibrary.org/obo/CL_0000988	hematopoietic cell		A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
http://purl.obolibrary.org/obo/CL_0000764	erythroid lineage cell	http://purl.obolibrary.org/obo/CL_0000763	myeloid cell		A immature or mature cell in the lineage leading to and including erythrocytes.
http://purl.obolibrary.org/obo/CL_0000765	erythroblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.
http://purl.obolibrary.org/obo/CL_0000766	myeloid leukocyte	http://purl.obolibrary.org/obo/CL_0000763	myeloid cell		A cell of the monocyte, granulocyte, or mast cell lineage.
http://purl.obolibrary.org/obo/CL_0000767	basophil	http://purl.obolibrary.org/obo/CL_0000094	granulocyte		Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.
http://purl.obolibrary.org/obo/CL_0000771	eosinophil	http://purl.obolibrary.org/obo/CL_0000094	granulocyte		Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.
http://purl.obolibrary.org/obo/CL_0000775	neutrophil	http://purl.obolibrary.org/obo/CL_0000094	granulocyte		Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
http://purl.obolibrary.org/obo/CL_0000782	myeloid dendritic cell	http://purl.obolibrary.org/obo/CL_0000990	conventional dendritic cell		A dendritic cell of the myeloid lineage.
http://purl.obolibrary.org/obo/CL_0000783	multinucleated phagocyte	http://purl.obolibrary.org/obo/CL_0000518	phagocyte (sensu Vertebrata)		A phagocyte formed by the fusion of mononuclear phagocytes.
http://purl.obolibrary.org/obo/CL_0000785	mature B cell	http://purl.obolibrary.org/obo/CL_0001201	B cell, CD19-positive		A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen.
http://purl.obolibrary.org/obo/CL_0000787	memory B cell	http://purl.obolibrary.org/obo/CL_0000785	mature B cell		A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative.
http://purl.obolibrary.org/obo/CL_0000788	naive B cell	http://purl.obolibrary.org/obo/CL_0000785	mature B cell		A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery.
http://purl.obolibrary.org/obo/CL_0000789	alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000084	T cell		A T cell that expresses an alpha-beta T cell receptor complex.
http://purl.obolibrary.org/obo/CL_0000790	immature alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0002420	immature T cell		An alpha-beta T cell that has an immature phenotype and has not completed T cell selection.
http://purl.obolibrary.org/obo/CL_0000791	mature alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0002419	mature T cell		A alpha-beta T cell that has a mature phenotype.
http://purl.obolibrary.org/obo/CL_0000792	CD4-positive, CD25-positive, alpha-beta regulatory T cell	http://purl.obolibrary.org/obo/CL_0000815	regulatory T cell		A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.
http://purl.obolibrary.org/obo/CL_0000795	CD8-positive, alpha-beta regulatory T cell	http://purl.obolibrary.org/obo/CL_0000815	regulatory T cell		A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.
http://purl.obolibrary.org/obo/CL_0000798	gamma-delta T cell	http://purl.obolibrary.org/obo/CL_0000084	T cell		A T cell that expresses a gamma-delta T cell receptor complex.
http://purl.obolibrary.org/obo/CL_0000799	immature gamma-delta T cell	http://purl.obolibrary.org/obo/CL_0002420	immature T cell		A gamma-delta T cell that has an immature phenotype.
http://purl.obolibrary.org/obo/CL_0000800	mature gamma-delta T cell	http://purl.obolibrary.org/obo/CL_0002419	mature T cell		A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location.
http://purl.obolibrary.org/obo/CL_0000805	immature single positive thymocyte	http://purl.obolibrary.org/obo/CL_0000893	thymocyte		A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive.
http://purl.obolibrary.org/obo/CL_0000806	DN2 thymocyte	http://purl.obolibrary.org/obo/CL_0002489	double negative thymocyte		A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive.
http://purl.obolibrary.org/obo/CL_0000807	DN3 thymocyte	http://purl.obolibrary.org/obo/CL_0002489	double negative thymocyte		A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain.
http://purl.obolibrary.org/obo/CL_0000808	DN4 thymocyte	http://purl.obolibrary.org/obo/CL_0002489	double negative thymocyte		A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.
http://purl.obolibrary.org/obo/CL_0000809	double-positive, alpha-beta thymocyte	http://purl.obolibrary.org/obo/CL_0000893	thymocyte		A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors.
http://purl.obolibrary.org/obo/CL_0000810	CD4-positive, alpha-beta thymocyte	http://purl.obolibrary.org/obo/CL_0000893	thymocyte		An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative.
http://purl.obolibrary.org/obo/CL_0000811	CD8-positive, alpha-beta thymocyte	http://purl.obolibrary.org/obo/CL_0000893	thymocyte		An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative.
http://purl.obolibrary.org/obo/CL_0000813	memory T cell	http://purl.obolibrary.org/obo/CL_0002419	mature T cell		A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure.
http://purl.obolibrary.org/obo/CL_0000815	regulatory T cell	http://purl.obolibrary.org/obo/CL_0002419	mature T cell		A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.
http://purl.obolibrary.org/obo/CL_0000816	immature B cell	http://purl.obolibrary.org/obo/CL_0001201	B cell, CD19-positive		An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation.
http://purl.obolibrary.org/obo/CL_0000817	precursor B cell	http://purl.obolibrary.org/obo/CL_0001201	B cell, CD19-positive		A precursor B cell is a B cell with the phenotype CD10-positive.
http://purl.obolibrary.org/obo/CL_0000818	transitional stage B cell	http://purl.obolibrary.org/obo/CL_0001201	B cell, CD19-positive		An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen.
http://purl.obolibrary.org/obo/CL_0000819	B-1 B cell	http://purl.obolibrary.org/obo/CL_0000785	mature B cell		A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive.
http://purl.obolibrary.org/obo/CL_0000820	B-1a B cell	http://purl.obolibrary.org/obo/CL_0000819	B-1 B cell		A B-1 B cell that has the phenotype CD5-positive.
http://purl.obolibrary.org/obo/CL_0000821	B-1b B cell	http://purl.obolibrary.org/obo/CL_0000819	B-1 B cell		A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell.
http://purl.obolibrary.org/obo/CL_0000822	B-2 B cell	http://purl.obolibrary.org/obo/CL_0000785	mature B cell		A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative.
http://purl.obolibrary.org/obo/CL_0000823	immature natural killer cell	http://purl.obolibrary.org/obo/CL_0001082	immature innate lymphoid cell		A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR).
http://purl.obolibrary.org/obo/CL_0000824	mature natural killer cell	http://purl.obolibrary.org/obo/CL_0000623	natural killer cell		A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules.
http://purl.obolibrary.org/obo/CL_0000825	pro-NK cell	http://purl.obolibrary.org/obo/CL_0000838	lymphoid lineage restricted progenitor cell		A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative.
http://purl.obolibrary.org/obo/CL_0000826	pro-B cell	http://purl.obolibrary.org/obo/CL_0000838	lymphoid lineage restricted progenitor cell		A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
http://purl.obolibrary.org/obo/CL_0000827	pro-T cell	http://purl.obolibrary.org/obo/CL_0000838	lymphoid lineage restricted progenitor cell		A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.
http://purl.obolibrary.org/obo/CL_0000828	thromboblast	http://purl.obolibrary.org/obo/CL_0000839	myeloid lineage restricted progenitor cell		A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates.
http://purl.obolibrary.org/obo/CL_0000829	basophilic myeloblast	http://purl.obolibrary.org/obo/CL_0000835	myeloblast		A myeloblast committed to the basophil lineage.
http://purl.obolibrary.org/obo/CL_0000831	mast cell progenitor	http://purl.obolibrary.org/obo/CL_0000839	myeloid lineage restricted progenitor cell		A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative.
http://purl.obolibrary.org/obo/CL_0000835	myeloblast	http://purl.obolibrary.org/obo/CL_0002191	granulocytopoietic cell		The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow.
http://purl.obolibrary.org/obo/CL_0000837	hematopoietic multipotent progenitor cell	http://purl.obolibrary.org/obo/CL_0008001	hematopoietic precursor cell		A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.
http://purl.obolibrary.org/obo/CL_0000838	lymphoid lineage restricted progenitor cell	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A progenitor cell restricted to the lymphoid lineage.
http://purl.obolibrary.org/obo/CL_0000839	myeloid lineage restricted progenitor cell	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A progenitor cell restricted to the myeloid lineage.
http://purl.obolibrary.org/obo/CL_0000842	mononuclear leukocyte	http://purl.obolibrary.org/obo/CL_0000738	leukocyte		A leukocyte with a single non-segmented nucleus in the mature form.
http://purl.obolibrary.org/obo/CL_0000843	follicular B cell	http://purl.obolibrary.org/obo/CL_0000822	B-2 B cell		A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative.
http://purl.obolibrary.org/obo/CL_0000844	germinal center B cell	http://purl.obolibrary.org/obo/CL_0000785	mature B cell		A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation.
http://purl.obolibrary.org/obo/CL_0000845	marginal zone B cell of spleen	http://purl.obolibrary.org/obo/CL_2000074	splenocyte		A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high.
http://purl.obolibrary.org/obo/CL_0000847	ciliated olfactory receptor neuron	http://purl.obolibrary.org/obo/CL_0000207	olfactory receptor cell		An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob.
http://purl.obolibrary.org/obo/CL_0000860	classical monocyte	http://purl.obolibrary.org/obo/CL_0000576	monocyte		A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.
http://purl.obolibrary.org/obo/CL_0000861	elicited macrophage	http://purl.obolibrary.org/obo/CL_0000235	macrophage		A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.
http://purl.obolibrary.org/obo/CL_0000862	suppressor macrophage	http://purl.obolibrary.org/obo/CL_0000861	elicited macrophage		A macrophage that suppresses immune responses.
http://purl.obolibrary.org/obo/CL_0000864	tissue-resident macrophage	http://purl.obolibrary.org/obo/CL_0000235	macrophage		A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
http://purl.obolibrary.org/obo/CL_0000878	central nervous system macrophage	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A tissue-resident macrophage found in the central nervous system.
http://purl.obolibrary.org/obo/CL_0000881	perivascular macrophage	http://purl.obolibrary.org/obo/CL_4042003	border associated macrophage		A border associated macrophage that is adjacent to a small blood vessel of a brain. A perivascular macrophage expresses the markers CD14, CD16 and CD163. In homeostatic conditions, this central nervous system macrophage has a non-motile cell body with extending and retracting projections through the blood vessel wall.
http://purl.obolibrary.org/obo/CL_0000889	myeloid suppressor cell	http://purl.obolibrary.org/obo/CL_0000766	myeloid leukocyte		An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive.
http://purl.obolibrary.org/obo/CL_0000891	foam cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.
http://purl.obolibrary.org/obo/CL_0000893	thymocyte	http://purl.obolibrary.org/obo/CL_0002420	immature T cell		An immature T cell located in the thymus.
http://purl.obolibrary.org/obo/CL_0000894	DN1 thymic pro-T cell	http://purl.obolibrary.org/obo/CL_0000827	pro-T cell		A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative.
http://purl.obolibrary.org/obo/CL_0000895	naive thymus-derived CD4-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000898	naive T cell		An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low.
http://purl.obolibrary.org/obo/CL_0000896	activated CD4-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000624	CD4-positive, alpha-beta T cell		A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive.
http://purl.obolibrary.org/obo/CL_0000897	CD4-positive, alpha-beta memory T cell	http://purl.obolibrary.org/obo/CL_0000813	memory T cell		A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell.
http://purl.obolibrary.org/obo/CL_0000898	naive T cell	http://purl.obolibrary.org/obo/CL_0002419	mature T cell		Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.
http://purl.obolibrary.org/obo/CL_0000900	naive thymus-derived CD8-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000898	naive T cell		A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.
http://purl.obolibrary.org/obo/CL_0000906	activated CD8-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000625	CD8-positive, alpha-beta T cell		A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative.
http://purl.obolibrary.org/obo/CL_0000907	central memory CD8-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0001203	CD8-positive, alpha-beta memory T cell, CD45RO-positive		CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/CL_0000908	CD8-positive, alpha-beta cytokine secreting effector T cell	http://purl.obolibrary.org/obo/CL_0000625	CD8-positive, alpha-beta T cell		A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines.
http://purl.obolibrary.org/obo/CL_0000909	CD8-positive, alpha-beta memory T cell	http://purl.obolibrary.org/obo/CL_0000813	memory T cell		A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell.
http://purl.obolibrary.org/obo/CL_0000911	effector T cell	http://purl.obolibrary.org/obo/CL_0002419	mature T cell		A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response.
http://purl.obolibrary.org/obo/CL_0000912	helper T cell	http://purl.obolibrary.org/obo/CL_0000911	effector T cell		A effector T cell that provides help in the form of secreted cytokines to other immune cells.
http://purl.obolibrary.org/obo/CL_0000913	effector memory CD8-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0001203	CD8-positive, alpha-beta memory T cell, CD45RO-positive		CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/CL_0000916	dendritic epidermal T cell	http://purl.obolibrary.org/obo/CL_0000800	mature gamma-delta T cell		A mature gamma-delta T cell located in the epidermis that regulates wound healing.
http://purl.obolibrary.org/obo/CL_0000936	early lymphoid progenitor	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative.
http://purl.obolibrary.org/obo/CL_0000937	pre-natural killer cell	http://purl.obolibrary.org/obo/CL_0000623	natural killer cell		Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins.
http://purl.obolibrary.org/obo/CL_0000945	lymphocyte of B lineage	http://purl.obolibrary.org/obo/CL_0000542	lymphocyte		A lymphocyte of B lineage with the commitment to express an immunoglobulin complex.
http://purl.obolibrary.org/obo/CL_0000946	antibody secreting cell	http://purl.obolibrary.org/obo/CL_0000945	lymphocyte of B lineage		A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin.
http://purl.obolibrary.org/obo/CL_0000948	IgE memory B cell	http://purl.obolibrary.org/obo/CL_4052108	IgD-negative class switched memory B cell		A class switched memory B cell that expresses IgE on the cell surface.
http://purl.obolibrary.org/obo/CL_0000949	IgD plasmablast	http://purl.obolibrary.org/obo/CL_0000980	plasmablast		A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult.
http://purl.obolibrary.org/obo/CL_0000950	IgE plasmablast	http://purl.obolibrary.org/obo/CL_0000980	plasmablast		A plasmablast that secretes IgE.
http://purl.obolibrary.org/obo/CL_0000954	small pre-B-II cell	http://purl.obolibrary.org/obo/CL_0000955	pre-B-II cell		A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes.
http://purl.obolibrary.org/obo/CL_0000955	pre-B-II cell	http://purl.obolibrary.org/obo/CL_0000817	precursor B cell		A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain.
http://purl.obolibrary.org/obo/CL_0000957	large pre-B-II cell	http://purl.obolibrary.org/obo/CL_0000955	pre-B-II cell		A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative.
http://purl.obolibrary.org/obo/CL_0000958	T1 B cell	http://purl.obolibrary.org/obo/CL_0000818	transitional stage B cell		A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative.
http://purl.obolibrary.org/obo/CL_0000959	T2 B cell	http://purl.obolibrary.org/obo/CL_0000818	transitional stage B cell		A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive.
http://purl.obolibrary.org/obo/CL_0000961	Bm1 B cell	http://purl.obolibrary.org/obo/CL_0000843	follicular B cell		A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells.
http://purl.obolibrary.org/obo/CL_0000962	Bm2 B cell	http://purl.obolibrary.org/obo/CL_0000843	follicular B cell		A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells.
http://purl.obolibrary.org/obo/CL_0000963	Bm3-delta B cell	http://purl.obolibrary.org/obo/CL_0000844	germinal center B cell		A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive.
http://purl.obolibrary.org/obo/CL_0000964	Bm2' B cell	http://purl.obolibrary.org/obo/CL_0000844	germinal center B cell		A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative.
http://purl.obolibrary.org/obo/CL_0000965	Bm3 B cell	http://purl.obolibrary.org/obo/CL_0000844	germinal center B cell		A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type.
http://purl.obolibrary.org/obo/CL_0000970	unswitched memory B cell	http://purl.obolibrary.org/obo/CL_0000787	memory B cell		An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative.
http://purl.obolibrary.org/obo/CL_0000971	IgM memory B cell	http://purl.obolibrary.org/obo/CL_0001053	IgD-negative memory B cell		An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative.
http://purl.obolibrary.org/obo/CL_0000972	class switched memory B cell	http://purl.obolibrary.org/obo/CL_0000787	memory B cell		A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface.
http://purl.obolibrary.org/obo/CL_0000973	IgA memory B cell	http://purl.obolibrary.org/obo/CL_4052108	IgD-negative class switched memory B cell		A class switched memory B cell that expresses IgA.
http://purl.obolibrary.org/obo/CL_0000979	IgG memory B cell	http://purl.obolibrary.org/obo/CL_0000972	class switched memory B cell		An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface.
http://purl.obolibrary.org/obo/CL_0000980	plasmablast	http://purl.obolibrary.org/obo/CL_0000946	antibody secreting cell		An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative.
http://purl.obolibrary.org/obo/CL_0000981	double negative memory B cell	http://purl.obolibrary.org/obo/CL_0001053	IgD-negative memory B cell		A memory B cell with the phenotype IgD-negative and CD27-negative.
http://purl.obolibrary.org/obo/CL_0000982	IgG plasmablast	http://purl.obolibrary.org/obo/CL_0000980	plasmablast		A plasmablast that secretes IgG.
http://purl.obolibrary.org/obo/CL_0000983	IgM plasmablast	http://purl.obolibrary.org/obo/CL_0000980	plasmablast		A plasmablast that secretes IgM.
http://purl.obolibrary.org/obo/CL_0000984	IgA plasmablast	http://purl.obolibrary.org/obo/CL_0000980	plasmablast		A plasmablast that secretes IgA.
http://purl.obolibrary.org/obo/CL_0000988	hematopoietic cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell of a hematopoietic lineage.
http://purl.obolibrary.org/obo/CL_0000990	conventional dendritic cell	http://purl.obolibrary.org/obo/CL_0000451	dendritic cell		Conventional dendritic cell is a dendritic cell that is CD11c-high.
http://purl.obolibrary.org/obo/CL_0001008	Kit and Sca1-positive hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0000037	hematopoietic stem cell		A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative.
http://purl.obolibrary.org/obo/CL_0001021	CD34-positive, CD38-positive common lymphoid progenitor	http://purl.obolibrary.org/obo/CL_0000995	CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor		A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.
http://purl.obolibrary.org/obo/CL_0001022	CD115-positive monocyte	http://purl.obolibrary.org/obo/CL_0001019	CD115-positive monocyte OR common dendritic progenitor		CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive.
http://purl.obolibrary.org/obo/CL_0001023	Kit-positive, CD34-positive common myeloid progenitor	http://purl.obolibrary.org/obo/CL_0001059	common myeloid progenitor, CD34-positive		A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low.
http://purl.obolibrary.org/obo/CL_0001024	CD34-positive, CD38-negative hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0000037	hematopoietic stem cell		CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.
http://purl.obolibrary.org/obo/CL_0001025	Kit-positive, Sca1-positive common lymphoid progenitor	http://purl.obolibrary.org/obo/CL_0001030	CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor		A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low.
http://purl.obolibrary.org/obo/CL_0001026	CD34-positive, CD38-positive common myeloid progenitor	http://purl.obolibrary.org/obo/CL_0001059	common myeloid progenitor, CD34-positive		A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.
http://purl.obolibrary.org/obo/CL_0001027	CD7-negative lymphoid progenitor cell	http://purl.obolibrary.org/obo/CL_0001012	CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor		CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.
http://purl.obolibrary.org/obo/CL_0001028	CD7-positive lymphoid progenitor cell	http://purl.obolibrary.org/obo/CL_0000051	common lymphoid progenitor		CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative.
http://purl.obolibrary.org/obo/CL_0001029	common dendritic progenitor	http://purl.obolibrary.org/obo/CL_0001019	CD115-positive monocyte OR common dendritic progenitor		Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers.
http://purl.obolibrary.org/obo/CL_0001031	cerebellar granule cell	http://purl.obolibrary.org/obo/CL_2000028	cerebellum glutamatergic neuron		An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers.
http://purl.obolibrary.org/obo/CL_0001032	cortical granule cell	http://purl.obolibrary.org/obo/CL_0010012	cerebral cortex neuron		Granule cell that is part of the cerebral cortex.
http://purl.obolibrary.org/obo/CL_0001033	hippocampal granule cell	http://purl.obolibrary.org/obo/CL_0002608	hippocampal neuron		Granule cell with a soma found in the hippocampus.
http://purl.obolibrary.org/obo/CL_0001035	bone cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A connective tissue cell found in bone.
http://purl.obolibrary.org/obo/CL_0001044	effector CD4-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000911	effector T cell		A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive.
http://purl.obolibrary.org/obo/CL_0001050	effector CD8-positive, alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000911	effector T cell		A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive.
http://purl.obolibrary.org/obo/CL_0001053	IgD-negative memory B cell	http://purl.obolibrary.org/obo/CL_0000787	memory B cell		A memory B cell that lacks expression of surface IgD.
http://purl.obolibrary.org/obo/CL_0001054	CD14-positive monocyte	http://purl.obolibrary.org/obo/CL_0000576	monocyte		A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20.
http://purl.obolibrary.org/obo/CL_0001055	CD14-positive, CD16-low monocyte	http://purl.obolibrary.org/obo/CL_0002397	CD14-positive, CD16-positive monocyte		An intermediate monocyte that is CD14-positive and with low amounts of CD16.
http://purl.obolibrary.org/obo/CL_0001059	common myeloid progenitor, CD34-positive	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.
http://purl.obolibrary.org/obo/CL_0001060	hematopoietic oligopotent progenitor cell, lineage-negative	http://purl.obolibrary.org/obo/CL_0002032	hematopoietic oligopotent progenitor cell		A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.
http://purl.obolibrary.org/obo/CL_0001062	effector memory CD8-positive, alpha-beta T cell, terminally differentiated	http://purl.obolibrary.org/obo/CL_4030002	effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated		A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.
http://purl.obolibrary.org/obo/CL_0002000	Kit-positive erythroid progenitor cell	http://purl.obolibrary.org/obo/CL_0001066	erythroid progenitor cell, mammalian		An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative.
http://purl.obolibrary.org/obo/CL_0002001	CD34-positive, CD38-positive granulocyte monocyte progenitor	http://purl.obolibrary.org/obo/CL_0000557	granulocyte monocyte progenitor cell		A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative.
http://purl.obolibrary.org/obo/CL_0002003	CD34-positive, GlyA-negative erythroid progenitor cell	http://purl.obolibrary.org/obo/CL_0001066	erythroid progenitor cell, mammalian		An erythroid progenitor cell that is CD34-positive and is GlyA-negative.
http://purl.obolibrary.org/obo/CL_0002004	CD34-negative, GlyA-negative proerythroblast	http://purl.obolibrary.org/obo/CL_0000547	proerythroblast		A proerythoblast that is CD34-negative and GlyA-negative.
http://purl.obolibrary.org/obo/CL_0002005	CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell	http://purl.obolibrary.org/obo/CL_0000050	megakaryocyte-erythroid progenitor cell		A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative.
http://purl.obolibrary.org/obo/CL_0002006	Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell	http://purl.obolibrary.org/obo/CL_0000050	megakaryocyte-erythroid progenitor cell		A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low.
http://purl.obolibrary.org/obo/CL_0002009	macrophage dendritic cell progenitor	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.
http://purl.obolibrary.org/obo/CL_0002010	pre-conventional dendritic cell	http://purl.obolibrary.org/obo/CL_0002031	hematopoietic lineage restricted progenitor cell		A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha.
http://purl.obolibrary.org/obo/CL_0002012	Kit-low proerythroblast	http://purl.obolibrary.org/obo/CL_0000547	proerythroblast		A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive.
http://purl.obolibrary.org/obo/CL_0002013	GlyA-positive basophilic erythroblast	http://purl.obolibrary.org/obo/CL_0000549	basophilic erythroblast		A basophilic erythroblast that is GlyA-positive.
http://purl.obolibrary.org/obo/CL_0002014	Kit-negative, Ly-76 high basophilic erythroblast	http://purl.obolibrary.org/obo/CL_0000549	basophilic erythroblast		A basophilic erythroblast that is Lyg 76-high and is Kit-negative.
http://purl.obolibrary.org/obo/CL_0002015	Kit-negative, Ly-76 high polychromatophilic erythroblast	http://purl.obolibrary.org/obo/CL_0000550	polychromatophilic erythroblast		A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative.
http://purl.obolibrary.org/obo/CL_0002016	CD71-low, GlyA-positive polychromatic erythroblast	http://purl.obolibrary.org/obo/CL_0000550	polychromatophilic erythroblast		A polychromatiic erythroblast that is Gly-A-positive and CD71-low.
http://purl.obolibrary.org/obo/CL_0002017	Kit-negative, Ly-76 high orthochromatophilic erythroblasts	http://purl.obolibrary.org/obo/CL_0000552	orthochromatic erythroblast		An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative.
http://purl.obolibrary.org/obo/CL_0002018	CD71-negative, GlyA-positive orthochromatic erythroblast	http://purl.obolibrary.org/obo/CL_0000552	orthochromatic erythroblast		An erythroblast that is GlyA-positive and CD71-negative.
http://purl.obolibrary.org/obo/CL_0002019	Ly-76 high reticulocyte	http://purl.obolibrary.org/obo/CL_0002422	enucleated reticulocyte		A reticulocyte that is Ly76-high and is Kit-negative.
http://purl.obolibrary.org/obo/CL_0002020	GlyA-positive reticulocytes	http://purl.obolibrary.org/obo/CL_0002422	enucleated reticulocyte		A reticulocyte that is GlyA-positive.
http://purl.obolibrary.org/obo/CL_0002021	GlyA-positive erythrocyte	http://purl.obolibrary.org/obo/CL_0000595	enucleate erythrocyte		An enucleate erythrocyte that is GlyA-positive.
http://purl.obolibrary.org/obo/CL_0002022	Ly-76 high positive erythrocyte	http://purl.obolibrary.org/obo/CL_0000595	enucleate erythrocyte		An enucleate erythrocyte that is Lyg-76-high.
http://purl.obolibrary.org/obo/CL_0002024	Kit-positive megakaryocyte progenitor cell	http://purl.obolibrary.org/obo/CL_0000553	megakaryocyte progenitor cell		A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low.
http://purl.obolibrary.org/obo/CL_0002027	CD9-positive, CD41-positive megakaryocyte cell	http://purl.obolibrary.org/obo/CL_0000556	megakaryocyte		A megakaryocyte cell with is CD9-positive and CD41-positive.
http://purl.obolibrary.org/obo/CL_0002028	basophil mast progenitor cell	http://purl.obolibrary.org/obo/CL_0002191	granulocytopoietic cell		A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa
http://purl.obolibrary.org/obo/CL_0002029	Fc-epsilon RIalpha-low mast cell progenitor	http://purl.obolibrary.org/obo/CL_0000831	mast cell progenitor		A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low.
http://purl.obolibrary.org/obo/CL_0002030	Fc-epsilon RIalpha-high basophil progenitor cell	http://purl.obolibrary.org/obo/CL_0000613	basophil progenitor cell		A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high.
http://purl.obolibrary.org/obo/CL_0002031	hematopoietic lineage restricted progenitor cell	http://purl.obolibrary.org/obo/CL_0008001	hematopoietic precursor cell		A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.
http://purl.obolibrary.org/obo/CL_0002032	hematopoietic oligopotent progenitor cell	http://purl.obolibrary.org/obo/CL_0008001	hematopoietic precursor cell		A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.
http://purl.obolibrary.org/obo/CL_0002033	short term hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0001008	Kit and Sca1-positive hematopoietic stem cell		A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative.
http://purl.obolibrary.org/obo/CL_0002034	long term hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0001008	Kit and Sca1-positive hematopoietic stem cell		A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative.
http://purl.obolibrary.org/obo/CL_0002035	Slamf1-negative multipotent progenitor cell	http://purl.obolibrary.org/obo/CL_0000837	hematopoietic multipotent progenitor cell		A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative.
http://purl.obolibrary.org/obo/CL_0002036	Slamf1-positive multipotent progenitor cell	http://purl.obolibrary.org/obo/CL_0000837	hematopoietic multipotent progenitor cell		A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive.
http://purl.obolibrary.org/obo/CL_0002043	CD34-positive, CD38-negative multipotent progenitor cell	http://purl.obolibrary.org/obo/CL_0000837	hematopoietic multipotent progenitor cell		A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.
http://purl.obolibrary.org/obo/CL_0002044	Kit-positive, integrin beta7-high basophil mast progenitor cell	http://purl.obolibrary.org/obo/CL_0002028	basophil mast progenitor cell		A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative.
http://purl.obolibrary.org/obo/CL_0002059	CD8-alpha-positive thymic conventional dendritic cell	http://purl.obolibrary.org/obo/CL_0000941	thymic conventional dendritic cell		A conventional thymic dendritic cell that is CD8-alpha-positive.
http://purl.obolibrary.org/obo/CL_0002062	pulmonary alveolar type 1 cell	http://purl.obolibrary.org/obo/CL_0000322	pulmonary alveolar epithelial cell		A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.
http://purl.obolibrary.org/obo/CL_0002063	pulmonary alveolar type 2 cell	http://purl.obolibrary.org/obo/CL_0020029	cuboidal epithelial cell		A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants via specialized organelles called alveolar lamellar bodies. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, has a rounded apical surface that projects above the level of the surrounding epithelium, and its free surface is covered by short microvilli.
http://purl.obolibrary.org/obo/CL_0002064	pancreatic acinar cell	http://purl.obolibrary.org/obo/CL_1001599	pancreas exocrine glandular cell		A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.
http://purl.obolibrary.org/obo/CL_0002067	type A enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0000170	glucagon secreting cell		An enteroendocrine cell that produces glucagon.
http://purl.obolibrary.org/obo/CL_0002068	Purkinje myocyte	http://purl.obolibrary.org/obo/CL_0002086	specialized cardiac myocyte		Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.
http://purl.obolibrary.org/obo/CL_0002072	nodal myocyte	http://purl.obolibrary.org/obo/CL_0002086	specialized cardiac myocyte		A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.
http://purl.obolibrary.org/obo/CL_0002073	transitional myocyte	http://purl.obolibrary.org/obo/CL_0002086	specialized cardiac myocyte		Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.
http://purl.obolibrary.org/obo/CL_0002074	myocardial endocrine cell	http://purl.obolibrary.org/obo/CL_0002086	specialized cardiac myocyte		The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).
http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell derived from endoderm.
http://purl.obolibrary.org/obo/CL_0002077	ecto-epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell derived from ectoderm.
http://purl.obolibrary.org/obo/CL_0002078	meso-epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		Epithelial cell derived from mesoderm or mesenchyme.
http://purl.obolibrary.org/obo/CL_0002079	pancreatic ductal cell	http://purl.obolibrary.org/obo/CL_1001433	epithelial cell of exocrine pancreas		Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH.
http://purl.obolibrary.org/obo/CL_0002080	pancreatic centro-acinar cell	http://purl.obolibrary.org/obo/CL_1001433	epithelial cell of exocrine pancreas		A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types.
http://purl.obolibrary.org/obo/CL_0002082	type II cell of adrenal medulla	http://purl.obolibrary.org/obo/CL_0000454	epinephrine secreting cell		A chromaffin cell of the adrenal medulla that produces epinephrine.
http://purl.obolibrary.org/obo/CL_0002083	type I cell of adrenal medulla	http://purl.obolibrary.org/obo/CL_0000459	noradrenergic cell		A chromaffin cell of the adrenal medulla that produces norepinephrine.
http://purl.obolibrary.org/obo/CL_0002086	specialized cardiac myocyte	http://purl.obolibrary.org/obo/CL_0000746	cardiac muscle cell		A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.
http://purl.obolibrary.org/obo/CL_0002087	nongranular leukocyte	http://purl.obolibrary.org/obo/CL_0000738	leukocyte		A leukocyte that lacks granules.
http://purl.obolibrary.org/obo/CL_0002092	bone marrow cell	http://purl.obolibrary.org/obo/CL_0001035	bone cell		A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.
http://purl.obolibrary.org/obo/CL_0002095	hilus cell of ovary	http://purl.obolibrary.org/obo/CL_0002132	stromal cell of ovary		A cell in the hilum of the ovary that produces androgens.
http://purl.obolibrary.org/obo/CL_0002097	cortical cell of adrenal gland	http://purl.obolibrary.org/obo/CL_1001601	adrenal gland glandular cell		A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol.
http://purl.obolibrary.org/obo/CL_0002101	CD38-positive naive B cell	http://purl.obolibrary.org/obo/CL_0000788	naive B cell		A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery.
http://purl.obolibrary.org/obo/CL_0002102	CD38-negative naive B cell	http://purl.obolibrary.org/obo/CL_0000788	naive B cell		A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery.
http://purl.obolibrary.org/obo/CL_0002103	IgG-positive double negative memory B cell	http://purl.obolibrary.org/obo/CL_0000981	double negative memory B cell		An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative.
http://purl.obolibrary.org/obo/CL_0002104	IgG-negative double negative memory B cell	http://purl.obolibrary.org/obo/CL_0000981	double negative memory B cell		An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative.
http://purl.obolibrary.org/obo/CL_0002105	CD38-positive IgG memory B cell	http://purl.obolibrary.org/obo/CL_0000979	IgG memory B cell		A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive.
http://purl.obolibrary.org/obo/CL_0002106	IgD-positive CD38-positive IgG memory B cell	http://purl.obolibrary.org/obo/CL_0002105	CD38-positive IgG memory B cell		An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive.
http://purl.obolibrary.org/obo/CL_0002107	IgD-negative CD38-positive IgG memory B cell	http://purl.obolibrary.org/obo/CL_4052108	IgD-negative class switched memory B cell		An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive.
http://purl.obolibrary.org/obo/CL_0002108	CD38-negative IgG memory B cell	http://purl.obolibrary.org/obo/CL_4052108	IgD-negative class switched memory B cell		A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive.
http://purl.obolibrary.org/obo/CL_0002109	B220-positive CD38-positive naive B cell	http://purl.obolibrary.org/obo/CL_0002101	CD38-positive naive B cell		A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery.
http://purl.obolibrary.org/obo/CL_0002110	B220-low CD38-positive naive B cell	http://purl.obolibrary.org/obo/CL_0002109	B220-positive CD38-positive naive B cell		A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery.
http://purl.obolibrary.org/obo/CL_0002111	CD38-negative unswitched memory B cell	http://purl.obolibrary.org/obo/CL_0000970	unswitched memory B cell		An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002112	B220-positive CD38-negative unswitched memory B cell	http://purl.obolibrary.org/obo/CL_0002111	CD38-negative unswitched memory B cell		A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002113	B220-low CD38-negative unswitched memory B cell	http://purl.obolibrary.org/obo/CL_0002112	B220-positive CD38-negative unswitched memory B cell		A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002114	CD38-positive unswitched memory B cell	http://purl.obolibrary.org/obo/CL_0000970	unswitched memory B cell		A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002115	B220-positive CD38-positive unswitched memory B cell	http://purl.obolibrary.org/obo/CL_0002114	CD38-positive unswitched memory B cell		A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002116	B220-low CD38-positive unswitched memory B cell	http://purl.obolibrary.org/obo/CL_0002115	B220-positive CD38-positive unswitched memory B cell		A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002117	IgG-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_4052108	IgD-negative class switched memory B cell		A class switched memory B cell that lacks IgG on the cell surface.
http://purl.obolibrary.org/obo/CL_0002118	CD38-negative IgG-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_0002117	IgG-negative class switched memory B cell		A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002119	CD38-positive IgG-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_0002117	IgG-negative class switched memory B cell		A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002120	CD24-positive CD38-negative IgG-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_0002118	CD38-negative IgG-negative class switched memory B cell		An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002121	CD24-negative CD38-negative IgG-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_0002118	CD38-negative IgG-negative class switched memory B cell		A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002122	B220-positive CD38-positive IgG-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_0002119	CD38-positive IgG-negative class switched memory B cell		A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative.
http://purl.obolibrary.org/obo/CL_0002123	B220-low CD38-positive IgG-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_0002122	B220-positive CD38-positive IgG-negative class switched memory B cell		A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive.
http://purl.obolibrary.org/obo/CL_0002124	CD27-positive gamma-delta T cell	http://purl.obolibrary.org/obo/CL_0000800	mature gamma-delta T cell		A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma.
http://purl.obolibrary.org/obo/CL_0002126	CD25-positive, CD27-positive immature gamma-delta T cell	http://purl.obolibrary.org/obo/CL_0000893	thymocyte		A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low).
http://purl.obolibrary.org/obo/CL_0002127	innate effector T cell	http://purl.obolibrary.org/obo/CL_0000911	effector T cell		A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation.
http://purl.obolibrary.org/obo/CL_0002132	stromal cell of ovary	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A stomal cell of the ovary
http://purl.obolibrary.org/obo/CL_0002134	stromal cell of ovarian medulla	http://purl.obolibrary.org/obo/CL_0002132	stromal cell of ovary		A stromal cell of the ovarian medulla.
http://purl.obolibrary.org/obo/CL_0002138	endothelial cell of lymphatic vessel	http://purl.obolibrary.org/obo/CL_0002139	endothelial cell of vascular tree		A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions.
http://purl.obolibrary.org/obo/CL_0002139	endothelial cell of vascular tree	http://purl.obolibrary.org/obo/CL_0000115	endothelial cell		An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.
http://purl.obolibrary.org/obo/CL_0002140	skin sebocyte	http://purl.obolibrary.org/obo/CL_0000622	acinar cell		An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles.
http://purl.obolibrary.org/obo/CL_0002144	capillary endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		An endothelial cell found in capillaries.
http://purl.obolibrary.org/obo/CL_0002145	multiciliated columnar cell of tracheobronchial tree	http://purl.obolibrary.org/obo/CL_4030034	respiratory tract multiciliated cell		A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx.
http://purl.obolibrary.org/obo/CL_0002148	dental pulp cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A cell found within the dental pulp.
http://purl.obolibrary.org/obo/CL_0002149	epithelial cell of uterus	http://purl.obolibrary.org/obo/CL_0002078	meso-epithelial cell		An epithelial cell of the uterus. This cell has a mesodermal origin.
http://purl.obolibrary.org/obo/CL_0002152	columnar cell of endocervix	http://purl.obolibrary.org/obo/CL_0002535	epithelial cell of cervix		A simple columnar epithelial cell located in the endocervix.
http://purl.obolibrary.org/obo/CL_0002153	corneocyte	http://purl.obolibrary.org/obo/CL_0000311	keratin accumulating cell		The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus.
http://purl.obolibrary.org/obo/CL_0002159	general ecto-epithelial cell	http://purl.obolibrary.org/obo/CL_0002077	ecto-epithelial cell		Epithelial cells derived from general body ectoderm and ectoderm placodes.
http://purl.obolibrary.org/obo/CL_0002166	epithelial cell of Malassez	http://purl.obolibrary.org/obo/CL_0002159	general ecto-epithelial cell		An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth.
http://purl.obolibrary.org/obo/CL_0002170	keratinized cell of the oral mucosa	http://purl.obolibrary.org/obo/CL_0002336	buccal mucosa cell		A keratinized cell located in the hard palate or gingiva.
http://purl.obolibrary.org/obo/CL_0002177	folliculostellate cell of pars distalis of adenohypophysis	http://purl.obolibrary.org/obo/CL_0000710	neurecto-epithelial cell		A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature.
http://purl.obolibrary.org/obo/CL_0002178	epithelial cell of stomach	http://purl.obolibrary.org/obo/CL_0002251	epithelial cell of alimentary canal		An epithelial cell found in the lining of the stomach.
http://purl.obolibrary.org/obo/CL_0002180	mucous cell of stomach	http://purl.obolibrary.org/obo/CL_0002178	epithelial cell of stomach		An epithelial cell of the stomach. This cell produces mucous.
http://purl.obolibrary.org/obo/CL_0002183	stem cell of gastric gland	http://purl.obolibrary.org/obo/CL_0002178	epithelial cell of stomach		A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.
http://purl.obolibrary.org/obo/CL_0002187	basal cell of epidermis	http://purl.obolibrary.org/obo/CL_4052061	epidermal keratinocyte		A mitotically active, columnar-shaped keratinocyte located in the stratum basale of the epidermis and attached to the basement membrane. This cell exhibits heterogeneity, encompassing stem and progenitor subpopulations with distinct molecular and proliferative characteristics (Haensel et al., 2020), and serves as the primary source of new keratinocytes for epidermal renewal, homeostasis, and regeneration.
http://purl.obolibrary.org/obo/CL_0002188	glomerular endothelial cell	http://purl.obolibrary.org/obo/CL_0002681	kidney cortical cell		An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate.
http://purl.obolibrary.org/obo/CL_0002191	granulocytopoietic cell	http://purl.obolibrary.org/obo/CL_0000839	myeloid lineage restricted progenitor cell		A cell involved in the formation of a granulocyte.
http://purl.obolibrary.org/obo/CL_0002194	monopoietic cell	http://purl.obolibrary.org/obo/CL_0000839	myeloid lineage restricted progenitor cell		A cell involved in the formation of a monocyte (monopoiesis).
http://purl.obolibrary.org/obo/CL_0002195	hepatic stem cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes).
http://purl.obolibrary.org/obo/CL_0002198	oncocyte	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands.
http://purl.obolibrary.org/obo/CL_0002199	oxyphil cell of parathyroid gland	http://purl.obolibrary.org/obo/CL_0002260	epithelial cell of parathyroid gland		An oncocyte located in the parathyroid gland.
http://purl.obolibrary.org/obo/CL_0002200	oxyphil cell of thyroid	http://purl.obolibrary.org/obo/CL_0002257	epithelial cell of thyroid gland		An oncocyte located in the thyroid.
http://purl.obolibrary.org/obo/CL_0002202	epithelial cell of tracheobronchial tree	http://purl.obolibrary.org/obo/CL_0002632	epithelial cell of lower respiratory tract		An epithelial cell of the tracheobronchial tree.
http://purl.obolibrary.org/obo/CL_0002209	intermediate epitheliocyte	http://purl.obolibrary.org/obo/CL_0002202	epithelial cell of tracheobronchial tree		An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.
http://purl.obolibrary.org/obo/CL_0002218	immature dendritic epithelial T cell precursor	http://purl.obolibrary.org/obo/CL_0002404	fetal thymocyte		A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18.
http://purl.obolibrary.org/obo/CL_0002220	interstitial cell of pineal gland	http://purl.obolibrary.org/obo/CL_0000710	neurecto-epithelial cell		A cell located between the pinealocytes.
http://purl.obolibrary.org/obo/CL_0002222	vertebrate lens cell	http://purl.obolibrary.org/obo/CL_0000306	crystallin accumulating cell		A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.
http://purl.obolibrary.org/obo/CL_0002224	lens epithelial cell	http://purl.obolibrary.org/obo/CL_0002222	vertebrate lens cell		A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.
http://purl.obolibrary.org/obo/CL_0002231	epithelial cell of prostate	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An epithelial cell of the prostate.
http://purl.obolibrary.org/obo/CL_0002232	epithelial cell of prostatic duct	http://purl.obolibrary.org/obo/CL_0002231	epithelial cell of prostate		An epithelial cell of prostatic duct.
http://purl.obolibrary.org/obo/CL_0002236	basal epithelial cell of prostatic duct	http://purl.obolibrary.org/obo/CL_0002341	basal cell of prostate epithelium		A cell that constitutes the basal layer of epithelium in the prostatic duct.
http://purl.obolibrary.org/obo/CL_0002240	marrow fibroblast	http://purl.obolibrary.org/obo/CL_0010001	stromal cell of bone marrow		A fibroblast in the bone marrow.
http://purl.obolibrary.org/obo/CL_0002241	pulmonary interstitial fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.
http://purl.obolibrary.org/obo/CL_0002242	nucleate cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell containing at least one nucleus.
http://purl.obolibrary.org/obo/CL_0002243	smooth muscle cell of sphincter of pupil	http://purl.obolibrary.org/obo/CL_0000358	sphincter associated smooth muscle cell		A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells.
http://purl.obolibrary.org/obo/CL_0002244	squamous cell of ectocervix	http://purl.obolibrary.org/obo/CL_1001575	uterine cervix squamous cell		A stratified squamous epithelial cell located in the ectocervix.
http://purl.obolibrary.org/obo/CL_0002246	peripheral blood stem cell	http://purl.obolibrary.org/obo/CL_0000080	circulating cell		A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).
http://purl.obolibrary.org/obo/CL_0002250	intestinal crypt stem cell	http://purl.obolibrary.org/obo/CL_0002563	intestinal epithelial cell		A stem cell located in epithelium the based of the crypt of Lieberkuhn. Division of these cells serve both to maintain the stem cell population and produce the transit amplifying cells that are all precursors of all cell types that populate the intestinal epithelium.
http://purl.obolibrary.org/obo/CL_0002251	epithelial cell of alimentary canal	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.
http://purl.obolibrary.org/obo/CL_0002252	epithelial cell of esophagus	http://purl.obolibrary.org/obo/CL_0002251	epithelial cell of alimentary canal		An epithelial cell of the lining of the esophagus.
http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine	http://purl.obolibrary.org/obo/CL_0002563	intestinal epithelial cell		An epithelial cell of the lining of the large intestine.
http://purl.obolibrary.org/obo/CL_0002254	epithelial cell of small intestine	http://purl.obolibrary.org/obo/CL_0002563	intestinal epithelial cell		An epithelial cell of the lining of the small intestine.
http://purl.obolibrary.org/obo/CL_0002255	stromal cell of endometrium	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone.
http://purl.obolibrary.org/obo/CL_0002257	epithelial cell of thyroid gland	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An epithelial cell of thyroid gland.
http://purl.obolibrary.org/obo/CL_0002258	thyroid follicular cell	http://purl.obolibrary.org/obo/CL_0002257	epithelial cell of thyroid gland		An epithelial cell that is part of the thyroid follicle epithelium, with a shape that ranges from squamous when inactive to cuboidal or columnar when active, reflecting its hormonal activity. Its apical surface is lined with microvilli projecting into the colloid-filled lumen, where it synthesizes, stores, and secretes the thyroid hormones thyroxine (T4) and triiodothyronine (T3), releasing them into the bloodstream in response to thyroid-stimulating hormone (TSH).
http://purl.obolibrary.org/obo/CL_0002260	epithelial cell of parathyroid gland	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An epithelial cell of the parathyroid gland.
http://purl.obolibrary.org/obo/CL_0002261	endothelial cell of viscerocranial mucosa	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An endothelial cell found in the mucosa associated with the facial skeleton.
http://purl.obolibrary.org/obo/CL_0002262	endothelial cell of sinusoid	http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell		An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.
http://purl.obolibrary.org/obo/CL_0002264	type A cell of stomach	http://purl.obolibrary.org/obo/CL_1001517	stomach enteroendocrine cell		A type of enteroendocrine cell found in the stomach that secretes glucagon.
http://purl.obolibrary.org/obo/CL_0002265	type D cell of colon	http://purl.obolibrary.org/obo/CL_0009042	enteroendocrine cell of colon		A D cell located in the colon.
http://purl.obolibrary.org/obo/CL_0002266	type D cell of small intestine	http://purl.obolibrary.org/obo/CL_0009006	enteroendocrine cell of small intestine		A type D cell of the small intestine.
http://purl.obolibrary.org/obo/CL_0002267	type D cell of stomach	http://purl.obolibrary.org/obo/CL_1000222	stomach neuroendocrine cell		A type D cell found in the stomach.
http://purl.obolibrary.org/obo/CL_0002274	histamine secreting cell	http://purl.obolibrary.org/obo/CL_0000457	biogenic amine secreting cell		A cell type that secretes histamine.
http://purl.obolibrary.org/obo/CL_0002275	pancreatic PP cell	http://purl.obolibrary.org/obo/CL_0008024	pancreatic endocrine cell		A PP cell located in the islets of the pancreas.
http://purl.obolibrary.org/obo/CL_0002293	epithelial cell of thymus	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies.
http://purl.obolibrary.org/obo/CL_0002294	type-1 epithelial cell of thymus	http://purl.obolibrary.org/obo/CL_0002364	cortical thymic epithelial cell		An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule.
http://purl.obolibrary.org/obo/CL_0002308	epithelial cell of skin gland	http://purl.obolibrary.org/obo/CL_0002159	general ecto-epithelial cell		An epithelial cell of a skin gland.
http://purl.obolibrary.org/obo/CL_0002312	somatotroph	http://purl.obolibrary.org/obo/CL_0000638	acidophil cell of pars distalis of adenohypophysis		An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.
http://purl.obolibrary.org/obo/CL_0002313	endocrine-paracrine cell of prostate gland	http://purl.obolibrary.org/obo/CL_0002159	general ecto-epithelial cell		An ecto-epithelial cell of the prostate gland that secretes hormones.
http://purl.obolibrary.org/obo/CL_0002319	neural cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell that is part of the nervous system.
http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest.
http://purl.obolibrary.org/obo/CL_0002321	embryonic cell (metazoa)	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell of the embryo.
http://purl.obolibrary.org/obo/CL_0002325	lactocyte	http://purl.obolibrary.org/obo/CL_1001586	mammary gland glandular cell		A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland.
http://purl.obolibrary.org/obo/CL_0002326	luminal epithelial cell of mammary gland	http://purl.obolibrary.org/obo/CL_0002327	mammary gland epithelial cell		A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast.
http://purl.obolibrary.org/obo/CL_0002327	mammary gland epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell of the mammary gland.
http://purl.obolibrary.org/obo/CL_0002328	bronchial epithelial cell	http://purl.obolibrary.org/obo/CL_0002202	epithelial cell of tracheobronchial tree		An epithelial cell of the bronchus.
http://purl.obolibrary.org/obo/CL_0002329	basal epithelial cell of tracheobronchial tree	http://purl.obolibrary.org/obo/CL_0002202	epithelial cell of tracheobronchial tree		An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury.
http://purl.obolibrary.org/obo/CL_0002332	multiciliated epithelial cell of the bronchus	http://purl.obolibrary.org/obo/CL_0002328	bronchial epithelial cell		A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface.
http://purl.obolibrary.org/obo/CL_0002333	neural crest derived adipocyte	http://purl.obolibrary.org/obo/CL_0000136	adipocyte		An adipocyte derived from a neural crest cell.
http://purl.obolibrary.org/obo/CL_0002336	buccal mucosa cell	http://purl.obolibrary.org/obo/CL_0002261	endothelial cell of viscerocranial mucosa		An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek.
http://purl.obolibrary.org/obo/CL_0002339	prostate stem cell	http://purl.obolibrary.org/obo/CL_0002341	basal cell of prostate epithelium		A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium.
http://purl.obolibrary.org/obo/CL_0002341	basal cell of prostate epithelium	http://purl.obolibrary.org/obo/CL_0002231	epithelial cell of prostate		An undifferentiated cell of the prostate epithelium that lacks secretory activity.
http://purl.obolibrary.org/obo/CL_0002350	endocardial cell	http://purl.obolibrary.org/obo/CL_0010008	cardiac endothelial cell		An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.
http://purl.obolibrary.org/obo/CL_0002351	progenitor cell of endocrine pancreas	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.
http://purl.obolibrary.org/obo/CL_0002352	gestational hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0000037	hematopoietic stem cell		A hematopoietic stem cell that exists during embryogenesis.
http://purl.obolibrary.org/obo/CL_0002353	fetal liver hematopoietic progenitor cell	http://purl.obolibrary.org/obo/CL_0002352	gestational hematopoietic stem cell		A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative.
http://purl.obolibrary.org/obo/CL_0002354	yolk sac hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0002352	gestational hematopoietic stem cell		A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive.
http://purl.obolibrary.org/obo/CL_0002359	placental hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0002352	gestational hematopoietic stem cell		A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells.
http://purl.obolibrary.org/obo/CL_0002362	cerebellar granule cell precursor	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive.
http://purl.obolibrary.org/obo/CL_0002363	keratocyte	http://purl.obolibrary.org/obo/CL_0000005	neural crest derived fibroblast		A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.
http://purl.obolibrary.org/obo/CL_0002364	cortical thymic epithelial cell	http://purl.obolibrary.org/obo/CL_0002293	epithelial cell of thymus		An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells.
http://purl.obolibrary.org/obo/CL_0002365	medullary thymic epithelial cell	http://purl.obolibrary.org/obo/CL_0002293	epithelial cell of thymus		An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.
http://purl.obolibrary.org/obo/CL_0002367	trabecular meshwork cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		An ocular connective tissue cell that is part of the eye's trabecular meshwork and is directly responsible for regulating the outflow of aqueous humor from the anterior chamber of the eye, thereby maintaining proper intraocular pressure.
http://purl.obolibrary.org/obo/CL_0002368	respiratory tract epithelial cell	http://purl.obolibrary.org/obo/CL_0002076	endo-epithelial cell		An epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin.
http://purl.obolibrary.org/obo/CL_0002370	respiratory tract goblet cell	http://purl.obolibrary.org/obo/CL_0008055	respiratory tract secretory epithelial cell		A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.
http://purl.obolibrary.org/obo/CL_0002372	myotube	http://purl.obolibrary.org/obo/CL_0000737	striated muscle cell		A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development.
http://purl.obolibrary.org/obo/CL_0002393	intermediate monocyte	http://purl.obolibrary.org/obo/CL_0000576	monocyte		A monocyte that has characteristics of both patrolling and inflammatory monocytes.
http://purl.obolibrary.org/obo/CL_0002397	CD14-positive, CD16-positive monocyte	http://purl.obolibrary.org/obo/CL_0001054	CD14-positive monocyte		A CD14-positive monocyte that is also CD16-positive and CCR2-negative.
http://purl.obolibrary.org/obo/CL_0002401	mature dendritic epithelial T cell precursor	http://purl.obolibrary.org/obo/CL_0002404	fetal thymocyte		A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18.
http://purl.obolibrary.org/obo/CL_0002404	fetal thymocyte	http://purl.obolibrary.org/obo/CL_0000893	thymocyte		A thymocyte found in the fetal thymus.
http://purl.obolibrary.org/obo/CL_0002405	gamma-delta thymocyte	http://purl.obolibrary.org/obo/CL_0002489	double negative thymocyte		A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative).
http://purl.obolibrary.org/obo/CL_0002419	mature T cell	http://purl.obolibrary.org/obo/CL_0000084	T cell		A T cell that expresses a T cell receptor complex and has completed T cell selection.
http://purl.obolibrary.org/obo/CL_0002420	immature T cell	http://purl.obolibrary.org/obo/CL_0000084	T cell		A T cell that has not completed T cell selection.
http://purl.obolibrary.org/obo/CL_0002421	nucleated reticulocyte	http://purl.obolibrary.org/obo/CL_0002242	nucleate cell		A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.
http://purl.obolibrary.org/obo/CL_0002422	enucleated reticulocyte	http://purl.obolibrary.org/obo/CL_0000558	reticulocyte		A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes.
http://purl.obolibrary.org/obo/CL_0002423	DN2a thymocyte	http://purl.obolibrary.org/obo/CL_0000806	DN2 thymocyte		A DN2 thymocyte that is Kit-hi.
http://purl.obolibrary.org/obo/CL_0002424	DN2b thymocyte	http://purl.obolibrary.org/obo/CL_0000806	DN2 thymocyte		A DN2 thymocyte that is Kit-low.
http://purl.obolibrary.org/obo/CL_0002425	early T lineage precursor	http://purl.obolibrary.org/obo/CL_0000827	pro-T cell		A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive.
http://purl.obolibrary.org/obo/CL_0002427	resting double-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000809	double-positive, alpha-beta thymocyte		A double-positive, alpha-beta thymocyte that is small and not proliferating.
http://purl.obolibrary.org/obo/CL_0002428	double-positive blast	http://purl.obolibrary.org/obo/CL_0000809	double-positive, alpha-beta thymocyte		A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating.
http://purl.obolibrary.org/obo/CL_0002429	CD69-positive double-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000809	double-positive, alpha-beta thymocyte		A double-positive thymocyte that is CD69-positive and has begun positive selection.
http://purl.obolibrary.org/obo/CL_0002430	CD4-intermediate, CD8-positive double-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000809	double-positive, alpha-beta thymocyte		A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor.
http://purl.obolibrary.org/obo/CL_0002431	CD4-positive, CD8-intermediate double-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000809	double-positive, alpha-beta thymocyte		A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor.
http://purl.obolibrary.org/obo/CL_0002432	CD24-positive, CD4 single-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000810	CD4-positive, alpha-beta thymocyte		A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor.
http://purl.obolibrary.org/obo/CL_0002433	CD69-positive, CD4-positive single-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000810	CD4-positive, alpha-beta thymocyte		A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive.
http://purl.obolibrary.org/obo/CL_0002434	CD24-positive, CD8 single-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000811	CD8-positive, alpha-beta thymocyte		A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor.
http://purl.obolibrary.org/obo/CL_0002435	CD69-positive, CD8-positive single-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000811	CD8-positive, alpha-beta thymocyte		A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive.
http://purl.obolibrary.org/obo/CL_0002436	mature CD4 single-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000624	CD4-positive, alpha-beta T cell		A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor.
http://purl.obolibrary.org/obo/CL_0002437	mature CD8 single-positive thymocyte	http://purl.obolibrary.org/obo/CL_0000625	CD8-positive, alpha-beta T cell		A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor.
http://purl.obolibrary.org/obo/CL_0002453	oligodendrocyte precursor cell	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2.
http://purl.obolibrary.org/obo/CL_0002454	CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell	http://purl.obolibrary.org/obo/CL_0002465	CD11b-positive dendritic cell		CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive.
http://purl.obolibrary.org/obo/CL_0002457	epidermal Langerhans cell	http://purl.obolibrary.org/obo/CL_0002465	CD11b-positive dendritic cell		A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive.
http://purl.obolibrary.org/obo/CL_0002460	CD8-alpha-negative thymic conventional dendritic cell	http://purl.obolibrary.org/obo/CL_0000941	thymic conventional dendritic cell		A conventional thymic dendritic cell that is CD8-alpha-negative.
http://purl.obolibrary.org/obo/CL_0002462	adipose dendritic cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A F4/80-negative dendritic cell located in adipose tissue.
http://purl.obolibrary.org/obo/CL_0002463	SIRPa-positive adipose dendritic cell	http://purl.obolibrary.org/obo/CL_0002462	adipose dendritic cell		An adipose dendritic cell that is SIRPa-positive.
http://purl.obolibrary.org/obo/CL_0002464	SIRPa-negative adipose dendritic cell	http://purl.obolibrary.org/obo/CL_0002462	adipose dendritic cell		An adipose dendritic cell that is SIRPa-negative.
http://purl.obolibrary.org/obo/CL_0002465	CD11b-positive dendritic cell	http://purl.obolibrary.org/obo/CL_0000990	conventional dendritic cell		A conventional dendritic cell that expresses CD11b (ITGAM).
http://purl.obolibrary.org/obo/CL_0002467	Gr1-high myeloid suppressor cell	http://purl.obolibrary.org/obo/CL_0000889	myeloid suppressor cell		A myeloid suppressor cell that is Gr1-high and CD11c-negative.
http://purl.obolibrary.org/obo/CL_0002468	Gr1-low myeloid suppressor cell	http://purl.obolibrary.org/obo/CL_0000889	myeloid suppressor cell		A myeloid suppressor cell that is Gr1-low and CD11c-positive.
http://purl.obolibrary.org/obo/CL_0002476	bone marrow macrophage	http://purl.obolibrary.org/obo/CL_0010004	mononuclear cell of bone marrow		A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive.
http://purl.obolibrary.org/obo/CL_0002477	adipose macrophage	http://purl.obolibrary.org/obo/CL_0000864	tissue-resident macrophage		A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive.
http://purl.obolibrary.org/obo/CL_0002478	F4/80-negative adipose macrophage	http://purl.obolibrary.org/obo/CL_0002477	adipose macrophage		An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions.
http://purl.obolibrary.org/obo/CL_0002479	F4/80-positive adipose macrophage	http://purl.obolibrary.org/obo/CL_0002477	adipose macrophage		An adipose macrophage that does not express MHC-II but is F4/80-positive.
http://purl.obolibrary.org/obo/CL_0002480	nasal mucosa goblet cell	http://purl.obolibrary.org/obo/CL_0002631	epithelial cell of upper respiratory tract		A goblet cell located in the nasal epithelium.
http://purl.obolibrary.org/obo/CL_0002482	dermal melanocyte	http://purl.obolibrary.org/obo/CL_1000458	melanocyte of skin		A melanocyte that produces pigment in the dermis.
http://purl.obolibrary.org/obo/CL_0002483	hair follicle melanocyte	http://purl.obolibrary.org/obo/CL_2000000	epidermal melanocyte		A melanocyte that produces pigment within the hair follicle.
http://purl.obolibrary.org/obo/CL_0002484	epithelial melanocyte	http://purl.obolibrary.org/obo/CL_0000148	melanocyte		A melanocyte that produces pigment in the epithelium.
http://purl.obolibrary.org/obo/CL_0002485	retinal melanocyte	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium.
http://purl.obolibrary.org/obo/CL_0002489	double negative thymocyte	http://purl.obolibrary.org/obo/CL_0000893	thymocyte		A thymocyte that lacks expression of CD4 and CD8.
http://purl.obolibrary.org/obo/CL_0002491	auditory epithelial cell	http://purl.obolibrary.org/obo/CL_0000098	sensory epithelial cell		A specialized cell involved in auditory sensory perception.
http://purl.obolibrary.org/obo/CL_0002494	cardiocyte	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell located in the heart, including both muscle and non muscle cells.
http://purl.obolibrary.org/obo/CL_0002503	adventitial cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc
http://purl.obolibrary.org/obo/CL_0002504	enteric smooth muscle cell	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell of the intestine.
http://purl.obolibrary.org/obo/CL_0002507	langerin-positive lymph node dendritic cell	http://purl.obolibrary.org/obo/CL_0000990	conventional dendritic cell		A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative.
http://purl.obolibrary.org/obo/CL_0002518	kidney epithelial cell	http://purl.obolibrary.org/obo/CL_1000497	kidney cell		An epithelial cell of the kidney.
http://purl.obolibrary.org/obo/CL_0002521	subcutaneous adipocyte	http://purl.obolibrary.org/obo/CL_0000136	adipocyte		An adipocyte that is part of subcutaneous adipose tissue.
http://purl.obolibrary.org/obo/CL_0002535	epithelial cell of cervix	http://purl.obolibrary.org/obo/CL_0002149	epithelial cell of uterus		An epithelial cell of the cervix.
http://purl.obolibrary.org/obo/CL_0002536	epithelial cell of amnion	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that is part of the amnion.
http://purl.obolibrary.org/obo/CL_0002537	amnion mesenchymal stem cell	http://purl.obolibrary.org/obo/CL_0000134	mesenchymal stem cell		A mesenchymal stem cell of the amnion membrane.
http://purl.obolibrary.org/obo/CL_0002538	intrahepatic cholangiocyte	http://purl.obolibrary.org/obo/CL_1000488	cholangiocyte		An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes.
http://purl.obolibrary.org/obo/CL_0002539	aortic smooth muscle cell	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		A smooth muscle cell of the aorta.
http://purl.obolibrary.org/obo/CL_0002540	mesenchymal stem cell of the bone marrow	http://purl.obolibrary.org/obo/CL_0002092	bone marrow cell		A mesenchymal stem cell that is part of the bone marrow.
http://purl.obolibrary.org/obo/CL_0002541	chorionic membrane mesenchymal stem cell	http://purl.obolibrary.org/obo/CL_0000134	mesenchymal stem cell		A mesenchymal stem cell of the chorionic membrane.
http://purl.obolibrary.org/obo/CL_0002543	vein endothelial cell	http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell		An endothelial cell that is part of the vein.
http://purl.obolibrary.org/obo/CL_0002547	fibroblast of the aortic adventitia	http://purl.obolibrary.org/obo/CL_1000306	fibroblast of tunica adventitia of artery		A fibroblast of the aortic adventitia.
http://purl.obolibrary.org/obo/CL_0002548	fibroblast of cardiac tissue	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		A fibroblast that is part of the heart.
http://purl.obolibrary.org/obo/CL_0002549	fibroblast of choroid plexus	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A fibroblast that is part of the choroid plexus.
http://purl.obolibrary.org/obo/CL_0002550	fibroblast of the conjunctiva	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast that is part of the conjuctiva of the eye.
http://purl.obolibrary.org/obo/CL_0002551	fibroblast of dermis	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		Any skin fibroblast that is part of some dermis.
http://purl.obolibrary.org/obo/CL_0002552	fibroblast of gingiva	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		Any fibroblast that is part of some gingiva.
http://purl.obolibrary.org/obo/CL_0002553	fibroblast of lung	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast that is part of lung.
http://purl.obolibrary.org/obo/CL_0002554	fibroblast of lymphatic vessel	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast of the lymphatic system.
http://purl.obolibrary.org/obo/CL_0002555	fibroblast of mammary gland	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast that is part of the mammary gland.
http://purl.obolibrary.org/obo/CL_0002556	fibroblast of periodontium	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast of the periodontium.
http://purl.obolibrary.org/obo/CL_0002557	fibroblast of pulmonary artery	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast of pulmonary artery.
http://purl.obolibrary.org/obo/CL_0002559	hair follicle cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		An animal cell that is part of a hair follicle.
http://purl.obolibrary.org/obo/CL_0002563	intestinal epithelial cell	http://purl.obolibrary.org/obo/CL_0002251	epithelial cell of alimentary canal		An epithelial cell of the lining of the intestine.
http://purl.obolibrary.org/obo/CL_0002564	nucleus pulposus cell of intervertebral disc	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A connective tissue cell of the nucleus pulposus cell of intervertebral disc.
http://purl.obolibrary.org/obo/CL_0002569	mesenchymal stem cell of umbilical cord	http://purl.obolibrary.org/obo/CL_0000349	extraembryonic cell		A mesenchymal stem cell of the umbilical cord.
http://purl.obolibrary.org/obo/CL_0002570	mesenchymal stem cell of adipose tissue	http://purl.obolibrary.org/obo/CL_0000134	mesenchymal stem cell		A mesenchymal stem cell of adipose tissue.
http://purl.obolibrary.org/obo/CL_0002571	hepatic mesenchymal stem cell	http://purl.obolibrary.org/obo/CL_0002195	hepatic stem cell		A mesenchymal stem cell of liver.
http://purl.obolibrary.org/obo/CL_0002572	vertebral mesenchymal stem cell	http://purl.obolibrary.org/obo/CL_0001035	bone cell		A mesenchymal stem cell of the vertebrae.
http://purl.obolibrary.org/obo/CL_0002574	stromal cell of pancreas	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A stromal cell of the pancreas.
http://purl.obolibrary.org/obo/CL_0002575	central nervous system pericyte	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A pericyte of the central nervous system.
http://purl.obolibrary.org/obo/CL_0002577	placental epithelial cell	http://purl.obolibrary.org/obo/CL_0000349	extraembryonic cell		An epithelial cell of the placenta.
http://purl.obolibrary.org/obo/CL_0002584	renal cortical epithelial cell	http://purl.obolibrary.org/obo/CL_0002681	kidney cortical cell		An epithelial cell of the kidney cortex.
http://purl.obolibrary.org/obo/CL_0002585	retinal blood vessel endothelial cell	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		A blood vessel endothelial cell that is part of the retina.
http://purl.obolibrary.org/obo/CL_0002586	retinal pigment epithelial cell	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		An epithelial cell of the retinal pigmented epithelium.
http://purl.obolibrary.org/obo/CL_0002589	smooth muscle cell of the brachiocephalic vasculature	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		A smooth muscle cell of the bachiocephalic vasculature.
http://purl.obolibrary.org/obo/CL_0002590	smooth muscle cell of the brain vasculature	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A vascular associated smooth muscle cell of the brain vasculature.
http://purl.obolibrary.org/obo/CL_0002591	smooth muscle cell of the pulmonary artery	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		A smooth muscle of the pulmonary artery.
http://purl.obolibrary.org/obo/CL_0002592	smooth muscle cell of the coronary artery	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		A smooth muscle cell of the coronary artery.
http://purl.obolibrary.org/obo/CL_0002593	smooth muscle cell of the internal thoracic artery	http://purl.obolibrary.org/obo/CL_0002595	smooth muscle cell of the subclavian artery		A smooth muscle of the internal thoracic artery.
http://purl.obolibrary.org/obo/CL_0002594	smooth muscle cell of the umbilical artery	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		A smooth muscle cell of the umbilical artery.
http://purl.obolibrary.org/obo/CL_0002595	smooth muscle cell of the subclavian artery	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		A smooth muscle cell of the subclavian artery.
http://purl.obolibrary.org/obo/CL_0002596	smooth muscle cell of the carotid artery	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		Smooth muscle cell of the carotid artery.
http://purl.obolibrary.org/obo/CL_0002597	smooth muscle cell of bladder	http://purl.obolibrary.org/obo/CL_1001319	bladder cell		A smooth muscle cell of the bladder.
http://purl.obolibrary.org/obo/CL_0002598	bronchial smooth muscle cell	http://purl.obolibrary.org/obo/CL_0019019	tracheobronchial smooth muscle cell		Any smooth muscle cell that is part of some bronchus.
http://purl.obolibrary.org/obo/CL_0002599	smooth muscle cell of the esophagus	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell of the esophagus.
http://purl.obolibrary.org/obo/CL_0002600	smooth muscle cell of trachea	http://purl.obolibrary.org/obo/CL_0019019	tracheobronchial smooth muscle cell		A smooth muscle cell of the trachea.
http://purl.obolibrary.org/obo/CL_0002601	uterine smooth muscle cell	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell of the uterus.
http://purl.obolibrary.org/obo/CL_0002602	annulus pulposus cell	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		Any connective tissue cell that is part of some annulus fibrosus disci intervertebralis.
http://purl.obolibrary.org/obo/CL_0002603	astrocyte of the cerebellum	http://purl.obolibrary.org/obo/CL_2000005	brain macroglial cell		An astrocyte of the cerebellum.
http://purl.obolibrary.org/obo/CL_0002604	hippocampal astrocyte	http://purl.obolibrary.org/obo/CL_1001580	hippocampal glial cell		An astrocyte that is part of the hippocampus.
http://purl.obolibrary.org/obo/CL_0002605	astrocyte of the cerebral cortex	http://purl.obolibrary.org/obo/CL_1001579	cerebral cortex glial cell		A transcriptomically distinct astrocyte that is found in the cerebral cortex.
http://purl.obolibrary.org/obo/CL_0002606	astrocyte of the spinal cord	http://purl.obolibrary.org/obo/CL_0000127	astrocyte		An astrocyte of the spinal cord.
http://purl.obolibrary.org/obo/CL_0002607	migratory enteric neural crest cell	http://purl.obolibrary.org/obo/CL_0000333	migratory neural crest cell		A neural crest cell that gives rise to cells of the enteric nervous system.
http://purl.obolibrary.org/obo/CL_0002608	hippocampal neuron	http://purl.obolibrary.org/obo/CL_0010012	cerebral cortex neuron		A neuron with a soma found in the hippocampus.
http://purl.obolibrary.org/obo/CL_0002610	raphe nuclei neuron	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A neuron of the raphe nuclei.
http://purl.obolibrary.org/obo/CL_0002612	neuron of the ventral spinal cord	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A neuron of the ventral spinal cord.
http://purl.obolibrary.org/obo/CL_0002613	striatum neuron	http://purl.obolibrary.org/obo/CL_0012001	neuron of the forebrain		A neuron of the striatum.
http://purl.obolibrary.org/obo/CL_0002614	neuron of the substantia nigra	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A neuron of the substantia nigra.
http://purl.obolibrary.org/obo/CL_0002617	adipocyte of breast	http://purl.obolibrary.org/obo/CL_0000136	adipocyte		An adipocyte that is part of the breast.
http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast of skin.
http://purl.obolibrary.org/obo/CL_0002621	gingival epithelial cell	http://purl.obolibrary.org/obo/CL_1001576	oral mucosa squamous cell		Any stratified squamous epithelial cell that is part of some gingival epithelium.
http://purl.obolibrary.org/obo/CL_0002622	prostate stromal cell	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A stromal cell of the prostate.
http://purl.obolibrary.org/obo/CL_0002623	acinar cell of salivary gland	http://purl.obolibrary.org/obo/CL_1001596	salivary gland glandular cell		An acinar cell that is part of the salivary gland epithelium, responsible for synthesizing and secreting the primary saliva essential for oral digestion, antimicrobial defense, and mucosal immunity. It features apical-basal polarity with apical secretory granules, and tight junctions that maintain polarity and regulate calcium-dependent saliva exocytosis triggered by parasympathetic and sympathetic signals (Ambudkar, 2015). This cell functions in coordination with contractile myoepithelial cells, which aid saliva flow through the ducts into the oral cavity (Khan et al., 2022). In mice and humans, acinar cell development relies on the transcription factor SOX2 (Emmerson et al., 2017), with self-renewal achieved primarily through acinar cell self-duplication and supported by progenitor populations during injury and regeneration (Aure et al., 2016).
http://purl.obolibrary.org/obo/CL_0002625	seminiferous tubule epithelial cell	http://purl.obolibrary.org/obo/CL_0000077	mesothelial cell		A cell of the seminiferous tubule epithelium.
http://purl.obolibrary.org/obo/CL_0002631	epithelial cell of upper respiratory tract	http://purl.obolibrary.org/obo/CL_0002368	respiratory tract epithelial cell		Any epithelial cell that is part of some upper respiratory tract epithelium.
http://purl.obolibrary.org/obo/CL_0002632	epithelial cell of lower respiratory tract	http://purl.obolibrary.org/obo/CL_0002368	respiratory tract epithelial cell		Any epithelial cell that is part of some lower respiratory tract epithelium.
http://purl.obolibrary.org/obo/CL_0002633	respiratory basal cell	http://purl.obolibrary.org/obo/CL_0000646	basal cell		A basal cell in the respiratory tract.
http://purl.obolibrary.org/obo/CL_0002634	epithelial cell of anal column	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		An epithelial cell of the anal column.
http://purl.obolibrary.org/obo/CL_0002637	keratinized epithelial cell of the anal canal	http://purl.obolibrary.org/obo/CL_0002634	epithelial cell of anal column		An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal.
http://purl.obolibrary.org/obo/CL_0002653	squamous endothelial cell	http://purl.obolibrary.org/obo/CL_0000115	endothelial cell		A squamous shaped endothelial cell.
http://purl.obolibrary.org/obo/CL_0002656	glandular endometrial unciliated epithelial cell	http://purl.obolibrary.org/obo/CL_0009084	glandular epithelial cell of endometrium		A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs.
http://purl.obolibrary.org/obo/CL_0002657	glandular cell of esophagus	http://purl.obolibrary.org/obo/CL_0002252	epithelial cell of esophagus		A glandular epithelial cell of the esophagus.
http://purl.obolibrary.org/obo/CL_0002658	glandular cell of the large intestine	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		A glandular epithelial cell of the large intestine.
http://purl.obolibrary.org/obo/CL_0002659	glandular epithelial cell of stomach	http://purl.obolibrary.org/obo/CL_0002178	epithelial cell of stomach		A glandular epithelial cell that is part of the stomach.
http://purl.obolibrary.org/obo/CL_0002663	myocardial endocrine cell of atrium	http://purl.obolibrary.org/obo/CL_0002074	myocardial endocrine cell		A myocardial endocrine cell that is part of the atrium.
http://purl.obolibrary.org/obo/CL_0002672	retinal progenitor cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.
http://purl.obolibrary.org/obo/CL_0002673	tongue muscle cell	http://purl.obolibrary.org/obo/CL_0008002	skeletal muscle fiber		A skeletal muscle cell that is part of the tongue.
http://purl.obolibrary.org/obo/CL_0002676	neural crest derived neuroblast	http://purl.obolibrary.org/obo/CL_0000031	neuroblast (sensu Vertebrata)		A neuroblast derived from a neural crest cell.
http://purl.obolibrary.org/obo/CL_0002678	memory regulatory T cell	http://purl.obolibrary.org/obo/CL_0000897	CD4-positive, alpha-beta memory T cell		A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen.
http://purl.obolibrary.org/obo/CL_0002679	natural helper lymphocyte	http://purl.obolibrary.org/obo/CL_0000542	lymphocyte		A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13
http://purl.obolibrary.org/obo/CL_0002680	PP cell of intestine	http://purl.obolibrary.org/obo/CL_1001516	intestinal enteroendocrine cell		A PP cell found in intestine.
http://purl.obolibrary.org/obo/CL_0002681	kidney cortical cell	http://purl.obolibrary.org/obo/CL_1000497	kidney cell		A cell that is part of a cortex of kidney.
http://purl.obolibrary.org/obo/CL_0005000	spinal cord interneuron	http://purl.obolibrary.org/obo/CL_0000099	interneuron		A CNS interneuron located in the spinal cord.
http://purl.obolibrary.org/obo/CL_0005009	renal principal cell	http://purl.obolibrary.org/obo/CL_0002518	kidney epithelial cell		A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system.
http://purl.obolibrary.org/obo/CL_0005012	multiciliated epithelial cell	http://purl.obolibrary.org/obo/CL_0000075	columnar/cuboidal epithelial cell		A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface.
http://purl.obolibrary.org/obo/CL_0005020	lymphangioblast	http://purl.obolibrary.org/obo/CL_4033054	perivascular cell		Lymphatic progenitor cells.
http://purl.obolibrary.org/obo/CL_0005022	vascular lymphangioblast	http://purl.obolibrary.org/obo/CL_0005020	lymphangioblast		Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells.
http://purl.obolibrary.org/obo/CL_0005024	somatomotor neuron	http://purl.obolibrary.org/obo/CL_0000108	cholinergic neuron		A motor neuron that innervates a skeletal muscle.  These motor neurons are all excitatory and cholinergic.
http://purl.obolibrary.org/obo/CL_0005026	hepatoblast	http://purl.obolibrary.org/obo/CL_0000048	multi fate stem cell		Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.
http://purl.obolibrary.org/obo/CL_0007000	preameloblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins.
http://purl.obolibrary.org/obo/CL_0007001	skeletogenic cell	http://purl.obolibrary.org/obo/CL_0000000	cell		Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).
http://purl.obolibrary.org/obo/CL_0007002	precementoblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		Skeletogenic cell that has the potential to develop into a cementoblast.
http://purl.obolibrary.org/obo/CL_0007003	preodontoblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell.
http://purl.obolibrary.org/obo/CL_0007004	premigratory neural crest cell	http://purl.obolibrary.org/obo/CL_0011012	neural crest cell		Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.
http://purl.obolibrary.org/obo/CL_0007009	prechondroblast	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.
http://purl.obolibrary.org/obo/CL_0007011	enteric neuron	http://purl.obolibrary.org/obo/CL_0000107	autonomic neuron		Neuron that is part of the enteric nervous system.
http://purl.obolibrary.org/obo/CL_0008000	non-striated muscle cell	http://purl.obolibrary.org/obo/CL_0000187	muscle cell		Any muscle cell in which the fibers are not organised into sarcomeres.
http://purl.obolibrary.org/obo/CL_0008001	hematopoietic precursor cell	http://purl.obolibrary.org/obo/CL_0000988	hematopoietic cell		Any hematopoietic cell that is a precursor of some other hematopoietic cell type.
http://purl.obolibrary.org/obo/CL_0008002	skeletal muscle fiber	http://purl.obolibrary.org/obo/CL_0002372	myotube		A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
http://purl.obolibrary.org/obo/CL_0008007	visceral muscle cell	http://purl.obolibrary.org/obo/CL_0000187	muscle cell		A muscle cell that is part of some visceral muscle.
http://purl.obolibrary.org/obo/CL_0008008	striated visceral muscle cell	http://purl.obolibrary.org/obo/CL_0008007	visceral muscle cell		A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods.
http://purl.obolibrary.org/obo/CL_0008009	transversely striated visceral muscle cell	http://purl.obolibrary.org/obo/CL_0008008	striated visceral muscle cell		A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods.
http://purl.obolibrary.org/obo/CL_0009000	sensory neuron of spinal nerve	http://purl.obolibrary.org/obo/CL_3000004	peripheral sensory neuron		A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.
http://purl.obolibrary.org/obo/CL_0009004	retinal cell	http://purl.obolibrary.org/obo/CL_0002319	neural cell		Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
http://purl.obolibrary.org/obo/CL_0009005	salivary gland cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any cell in a salivary gland.
http://purl.obolibrary.org/obo/CL_0010001	stromal cell of bone marrow	http://purl.obolibrary.org/obo/CL_0002092	bone marrow cell		A stromal cell that is part_of a bone marrow.
http://purl.obolibrary.org/obo/CL_0010002	epithelial cell of umbilical artery	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that is part_of a umbilical artery.
http://purl.obolibrary.org/obo/CL_0010004	mononuclear cell of bone marrow	http://purl.obolibrary.org/obo/CL_1001610	bone marrow hematopoietic cell		A mononuclear cell that is part_of a bone marrow.
http://purl.obolibrary.org/obo/CL_0010006	cardiac blood vessel endothelial cell	http://purl.obolibrary.org/obo/CL_0010008	cardiac endothelial cell		Any blood vessel endothelial cell that is part of some heart.
http://purl.obolibrary.org/obo/CL_0010008	cardiac endothelial cell	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		Any endothelial cell that is part of some heart.
http://purl.obolibrary.org/obo/CL_0010009	camera-type eye photoreceptor cell	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		Any photoreceptor cell that is part of some camera-type eye.
http://purl.obolibrary.org/obo/CL_0010010	cerebellar stellate cell	http://purl.obolibrary.org/obo/CL_0000691	stellate interneuron		A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling.
http://purl.obolibrary.org/obo/CL_0010011	cerebral cortex GABAergic interneuron	http://purl.obolibrary.org/obo/CL_0011005	GABAergic interneuron		A GABAergic interneuron whose soma is located in the cerebral cortex.
http://purl.obolibrary.org/obo/CL_0010012	cerebral cortex neuron	http://purl.obolibrary.org/obo/CL_0012001	neuron of the forebrain		A CNS neuron of the cerebral cortex.
http://purl.obolibrary.org/obo/CL_0010020	cardiac glial cell	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		Any glial cell that is part of some heart.
http://purl.obolibrary.org/obo/CL_0010021	cardiac myoblast	http://purl.obolibrary.org/obo/CL_0000056	myoblast		Any myoblast that develops into some cardiac muscle cell.
http://purl.obolibrary.org/obo/CL_0010022	cardiac neuron	http://purl.obolibrary.org/obo/CL_2000032	peripheral nervous system neuron		A neuron that has its soma in the heart.
http://purl.obolibrary.org/obo/CL_0011001	spinal cord motor neuron	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.
http://purl.obolibrary.org/obo/CL_0011005	GABAergic interneuron	http://purl.obolibrary.org/obo/CL_0000617	GABAergic neuron		An interneuron that uses GABA as a vesicular neurotransmitter.  These interneurons are inhibitory
http://purl.obolibrary.org/obo/CL_0011101	chorionic trophoblast cell	http://purl.obolibrary.org/obo/CL_0000351	trophoblast cell		Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.
http://purl.obolibrary.org/obo/CL_0011108	colon epithelial cell	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		Epithelial cell that is part of the colon epithelium.
http://purl.obolibrary.org/obo/CL_0011113	spiral ganglion neuron	http://purl.obolibrary.org/obo/CL_2000032	peripheral nervous system neuron		Neuron found in the spiral ganglion.
http://purl.obolibrary.org/obo/CL_0012000	astrocyte of the forebrain	http://purl.obolibrary.org/obo/CL_2000005	brain macroglial cell		An astrocyte of the forebrain.
http://purl.obolibrary.org/obo/CL_0012001	neuron of the forebrain	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A CNS neuron of the forebrain.
http://purl.obolibrary.org/obo/CL_0013000	forebrain radial glial cell	http://purl.obolibrary.org/obo/CL_0000681	radial glial cell		Any radial glial cell that is part of some forebrain.
http://purl.obolibrary.org/obo/CL_1000042	forebrain neuroblast	http://purl.obolibrary.org/obo/CL_0002319	neural cell		Any neuroblast (sensu Vertebrata) that is part of some forebrain.
http://purl.obolibrary.org/obo/CL_1000073	spinal cord radial glial cell	http://purl.obolibrary.org/obo/CL_0000681	radial glial cell		Any radial glial cell that is part of some spinal cord.
http://purl.obolibrary.org/obo/CL_1000090	pronephric nephron tubule epithelial cell	http://purl.obolibrary.org/obo/CL_1000507	kidney tubule cell		Any epithelial cell that is part of some pronephric nephron tubule.
http://purl.obolibrary.org/obo/CL_1000123	metanephric nephron tubule epithelial cell	http://purl.obolibrary.org/obo/CL_1000507	kidney tubule cell		Any epithelial cell that is part of some metanephric nephron tubule.
http://purl.obolibrary.org/obo/CL_1000143	lung goblet cell	http://purl.obolibrary.org/obo/CL_1000272	lung secretory cell		Any goblet cell that is part of some lung epithelium.
http://purl.obolibrary.org/obo/CL_1000147	cardiac valve cell	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		A cell that is part of a cardiac valve.
http://purl.obolibrary.org/obo/CL_1000222	stomach neuroendocrine cell	http://purl.obolibrary.org/obo/CL_1001517	stomach enteroendocrine cell		A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles.
http://purl.obolibrary.org/obo/CL_1000223	pulmonary neuroendocrine cell	http://purl.obolibrary.org/obo/CL_1000272	lung secretory cell		A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.
http://purl.obolibrary.org/obo/CL_1000271	lung multiciliated epithelial cell	http://purl.obolibrary.org/obo/CL_4030034	respiratory tract multiciliated cell		An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface.
http://purl.obolibrary.org/obo/CL_1000272	lung secretory cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any secretory cell that is part of some lung.
http://purl.obolibrary.org/obo/CL_1000274	trophectodermal cell	http://purl.obolibrary.org/obo/CL_0000349	extraembryonic cell		An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange.
http://purl.obolibrary.org/obo/CL_1000275	smooth muscle cell of small intestine	http://purl.obolibrary.org/obo/CL_0002504	enteric smooth muscle cell		A smooth muscle cell that is part of the small intestine.
http://purl.obolibrary.org/obo/CL_1000276	smooth muscle fiber of duodenum	http://purl.obolibrary.org/obo/CL_1000275	smooth muscle cell of small intestine		A smooth muscle cell that is part of the duodenum.
http://purl.obolibrary.org/obo/CL_1000277	smooth muscle fiber of jejunum	http://purl.obolibrary.org/obo/CL_1000275	smooth muscle cell of small intestine		A smooth muscle cell that is part of the jejunum.
http://purl.obolibrary.org/obo/CL_1000278	smooth muscle fiber of ileum	http://purl.obolibrary.org/obo/CL_1000275	smooth muscle cell of small intestine		A smooth muscle cell that is part of the ileum.
http://purl.obolibrary.org/obo/CL_1000279	smooth muscle cell of large intestine	http://purl.obolibrary.org/obo/CL_0002504	enteric smooth muscle cell		A smooth muscle cell that is part of the large intestine.
http://purl.obolibrary.org/obo/CL_1000280	smooth muscle cell of colon	http://purl.obolibrary.org/obo/CL_1000279	smooth muscle cell of large intestine		A smooth muscle cell that is part of the colon.
http://purl.obolibrary.org/obo/CL_1000284	smooth muscle fiber of descending colon	http://purl.obolibrary.org/obo/CL_1000280	smooth muscle cell of colon		A smooth muscle cell that is part of the descending colon.
http://purl.obolibrary.org/obo/CL_1000285	smooth muscle cell of sigmoid colon	http://purl.obolibrary.org/obo/CL_1000280	smooth muscle cell of colon		A smooth muscle cell that is part of the sigmoid colon.
http://purl.obolibrary.org/obo/CL_1000286	smooth muscle cell of rectum	http://purl.obolibrary.org/obo/CL_1000279	smooth muscle cell of large intestine		A smooth muscle cell that is part of the rectum.
http://purl.obolibrary.org/obo/CL_1000296	epithelial cell of urethra	http://purl.obolibrary.org/obo/CL_1001320	urethra cell		An epithelial cell that is part of the urethra.
http://purl.obolibrary.org/obo/CL_1000298	mesothelial cell of dura mater	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A mesothelial cell that is part of the dura mater.
http://purl.obolibrary.org/obo/CL_1000303	fibroblast of areolar connective tissue	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast that is part of the areolar connective tissue.
http://purl.obolibrary.org/obo/CL_1000306	fibroblast of tunica adventitia of artery	http://purl.obolibrary.org/obo/CL_4052030	adventitial fibroblast		A fibroblast that is part of the tunica adventitia of artery.
http://purl.obolibrary.org/obo/CL_1000307	fibroblast of dense regular elastic tissue	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast that is part of the dense regular elastic tissue.
http://purl.obolibrary.org/obo/CL_1000309	epicardial adipocyte	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		An adipocyte that is part of the epicardial fat.
http://purl.obolibrary.org/obo/CL_1000310	adipocyte of epicardial fat of right ventricle	http://purl.obolibrary.org/obo/CL_1000309	epicardial adipocyte		An adipocyte that is part of the epicardial fat of right ventricle.
http://purl.obolibrary.org/obo/CL_1000311	adipocyte of epicardial fat of left ventricle	http://purl.obolibrary.org/obo/CL_1000309	epicardial adipocyte		An adipocyte that is part of the epicardial fat of left ventricle.
http://purl.obolibrary.org/obo/CL_1000312	bronchial goblet cell	http://purl.obolibrary.org/obo/CL_0019003	tracheobronchial goblet cell		A goblet cell that is part of the epithelium of bronchus.
http://purl.obolibrary.org/obo/CL_1000313	gastric goblet cell	http://purl.obolibrary.org/obo/CL_0002180	mucous cell of stomach		A goblet cell that is part of the epithelium of stomach.
http://purl.obolibrary.org/obo/CL_1000317	intestinal villus goblet cell	http://purl.obolibrary.org/obo/CL_1000495	small intestine goblet cell		A goblet cell that is part of the epithelium of intestinal villus.
http://purl.obolibrary.org/obo/CL_1000320	large intestine goblet cell	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		A goblet cell that is part of the epithelium of large intestine.
http://purl.obolibrary.org/obo/CL_1000321	large intestine crypt goblet cell	http://purl.obolibrary.org/obo/CL_1000320	large intestine goblet cell		A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine.
http://purl.obolibrary.org/obo/CL_1000322	pancreatic goblet cell	http://purl.obolibrary.org/obo/CL_1001599	pancreas exocrine glandular cell		A goblet cell that is part of the epithelium of pancreatic duct.
http://purl.obolibrary.org/obo/CL_1000323	pyloric gastric gland goblet cell	http://purl.obolibrary.org/obo/CL_1000313	gastric goblet cell		A goblet cell that is part of the epithelium of pyloric gland.
http://purl.obolibrary.org/obo/CL_1000324	duodenal goblet cell	http://purl.obolibrary.org/obo/CL_1001589	duodenum secretory cell		A goblet cell that is part of the epithelium proper of duodenum.
http://purl.obolibrary.org/obo/CL_1000325	jejunal goblet cell	http://purl.obolibrary.org/obo/CL_1000317	intestinal villus goblet cell		A goblet cell that is part of the epithelium proper of jejunum.
http://purl.obolibrary.org/obo/CL_1000326	ileal goblet cell	http://purl.obolibrary.org/obo/CL_1000317	intestinal villus goblet cell		A goblet cell that is part of the epithelium proper of ileum.
http://purl.obolibrary.org/obo/CL_1000329	tracheal goblet cell	http://purl.obolibrary.org/obo/CL_0019003	tracheobronchial goblet cell		A goblet cell that is part of the epithelium of trachea.
http://purl.obolibrary.org/obo/CL_1000330	serous cell of epithelium of trachea	http://purl.obolibrary.org/obo/CL_0019001	tracheobronchial serous cell		A serous secreting cell that is part of the epithelium of trachea.
http://purl.obolibrary.org/obo/CL_1000331	serous cell of epithelium of bronchus	http://purl.obolibrary.org/obo/CL_0019001	tracheobronchial serous cell		A serous secreting cell that is part of the epithelium of bronchus.
http://purl.obolibrary.org/obo/CL_1000332	serous cell of epithelium of terminal bronchiole	http://purl.obolibrary.org/obo/CL_0019001	tracheobronchial serous cell		A serous secreting cell that is part of the epithelium of terminal bronchiole.
http://purl.obolibrary.org/obo/CL_1000348	basal cell of epithelium of trachea	http://purl.obolibrary.org/obo/CL_0002633	respiratory basal cell		A basal cell that is part of the epithelium of trachea.
http://purl.obolibrary.org/obo/CL_1000349	basal cell of epithelium of bronchus	http://purl.obolibrary.org/obo/CL_0002633	respiratory basal cell		A basal cell found in the bronchus epithelium.
http://purl.obolibrary.org/obo/CL_1000350	basal cell of epithelium of terminal bronchiole	http://purl.obolibrary.org/obo/CL_0002633	respiratory basal cell		A basal cell that is part of the epithelium of terminal bronchiole.
http://purl.obolibrary.org/obo/CL_1000351	basal cell of epithelium of respiratory bronchiole	http://purl.obolibrary.org/obo/CL_0002633	respiratory basal cell		A basal cell that is part of the epithelium of respiratory bronchiole.
http://purl.obolibrary.org/obo/CL_1000361	transitional myocyte of interatrial septum	http://purl.obolibrary.org/obo/CL_2000022	cardiac septum cell		A transitional myocyte that is part of the interatrial septum.
http://purl.obolibrary.org/obo/CL_1000362	transitional myocyte of interventricular septum	http://purl.obolibrary.org/obo/CL_2000022	cardiac septum cell		A transitional myocyte that is part of the interventricular septum.
http://purl.obolibrary.org/obo/CL_1000376	Purkinje myocyte of interventricular septum	http://purl.obolibrary.org/obo/CL_2000022	cardiac septum cell		A Purkinje myocyte that is part of the interventricular septum.
http://purl.obolibrary.org/obo/CL_1000391	melanocyte of eyelid	http://purl.obolibrary.org/obo/CL_0000148	melanocyte		A melanocyte that is part of the eyelid.
http://purl.obolibrary.org/obo/CL_1000398	endothelial cell of hepatic sinusoid	http://purl.obolibrary.org/obo/CL_0002262	endothelial cell of sinusoid		An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.
http://purl.obolibrary.org/obo/CL_1000409	myocyte of sinoatrial node	http://purl.obolibrary.org/obo/CL_0008009	transversely striated visceral muscle cell		A muscle cell that is part of the sinoatrial node.
http://purl.obolibrary.org/obo/CL_1000410	myocyte of atrioventricular node	http://purl.obolibrary.org/obo/CL_2000022	cardiac septum cell		A muscle cell that is part of the atrioventricular node.
http://purl.obolibrary.org/obo/CL_1000412	endothelial cell of arteriole	http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell		An endothelial cell that is part of the arteriole.
http://purl.obolibrary.org/obo/CL_1000413	endothelial cell of artery	http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell		A blood vessel endothelial cell that is part of an arterial endothelium.
http://purl.obolibrary.org/obo/CL_1000414	endothelial cell of venule	http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell		An endothelial cell that is part of the venule.
http://purl.obolibrary.org/obo/CL_1000415	epithelial cell of gallbladder	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that is part of the gallbladder.
http://purl.obolibrary.org/obo/CL_1000426	chromaffin cell of adrenal gland	http://purl.obolibrary.org/obo/CL_0000166	chromaffin cell		A chromaffin cell that is part of the adrenal gland.
http://purl.obolibrary.org/obo/CL_1000427	adrenal cortex chromaffin cell	http://purl.obolibrary.org/obo/CL_1001601	adrenal gland glandular cell		A chromaffin cell that is part of the adrenal cortex.
http://purl.obolibrary.org/obo/CL_1000428	stem cell of epidermis	http://purl.obolibrary.org/obo/CL_0000723	somatic stem cell		A somatic stem cell that is part of the epidermis.
http://purl.obolibrary.org/obo/CL_1000432	conjunctival epithelial cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that is part of the conjunctiva.
http://purl.obolibrary.org/obo/CL_1000434	epithelial cell of external acoustic meatus	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that is part of the external acoustic meatus.
http://purl.obolibrary.org/obo/CL_1000435	epithelial cell of lacrimal drainage system	http://purl.obolibrary.org/obo/CL_0000072	non-branched duct epithelial cell		An epithelial cell that is part of the lacrimal drainage system.
http://purl.obolibrary.org/obo/CL_1000436	epithelial cell of lacrimal sac	http://purl.obolibrary.org/obo/CL_1000437	epithelial cell of nasolacrimal duct		An epithelial cell that is part of the lacrimal sac.
http://purl.obolibrary.org/obo/CL_1000437	epithelial cell of nasolacrimal duct	http://purl.obolibrary.org/obo/CL_1000435	epithelial cell of lacrimal drainage system		An epithelial cell that is part of the nasolacrimal duct.
http://purl.obolibrary.org/obo/CL_1000443	ciliary muscle cell	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell that is part of the ciliary body.
http://purl.obolibrary.org/obo/CL_1000444	mesothelial cell of anterior chamber of eye	http://purl.obolibrary.org/obo/CL_0000077	mesothelial cell		A mesothelial cell that is part of the anterior chamber of eyeball.
http://purl.obolibrary.org/obo/CL_1000447	epithelial cell of stratum germinativum of esophagus	http://purl.obolibrary.org/obo/CL_0000646	basal cell		A basal cell that is part of the epithelium of esophagus.
http://purl.obolibrary.org/obo/CL_1000448	epithelial cell of sweat gland	http://purl.obolibrary.org/obo/CL_0002308	epithelial cell of skin gland		An epithelial cell that is part of the sweat gland.
http://purl.obolibrary.org/obo/CL_1000449	epithelial cell of nephron	http://purl.obolibrary.org/obo/CL_0002518	kidney epithelial cell		An epithelial cell that is part of the nephron.
http://purl.obolibrary.org/obo/CL_1000450	epithelial cell of glomerular capsule	http://purl.obolibrary.org/obo/CL_1000510	kidney glomerular epithelial cell		An epithelial cell that is part of the glomerular capsule.
http://purl.obolibrary.org/obo/CL_1000454	kidney collecting duct epithelial cell	http://purl.obolibrary.org/obo/CL_1001225	kidney collecting duct cell		An epithelial cell that is part of the collecting duct of renal tubule.
http://purl.obolibrary.org/obo/CL_1000456	mesothelial cell of parietal peritoneum	http://purl.obolibrary.org/obo/CL_1000490	mesothelial cell of peritoneum		A mesothelial cell that is part of the parietal peritoneum.
http://purl.obolibrary.org/obo/CL_1000457	mesothelial cell of visceral peritoneum	http://purl.obolibrary.org/obo/CL_1000490	mesothelial cell of peritoneum		A mesothelial cell that is part of the visceral peritoneum.
http://purl.obolibrary.org/obo/CL_1000458	melanocyte of skin	http://purl.obolibrary.org/obo/CL_0000148	melanocyte		A melanocyte that is part of the skin of body.
http://purl.obolibrary.org/obo/CL_1000465	chromaffin cell of ovary	http://purl.obolibrary.org/obo/CL_0000166	chromaffin cell		A chromaffin cell that is part of the ovary.
http://purl.obolibrary.org/obo/CL_1000466	chromaffin cell of right ovary	http://purl.obolibrary.org/obo/CL_1000465	chromaffin cell of ovary		A chromaffin cell that is part of the right ovary.
http://purl.obolibrary.org/obo/CL_1000467	chromaffin cell of left ovary	http://purl.obolibrary.org/obo/CL_1000465	chromaffin cell of ovary		A chromaffin cell that is part of the left ovary.
http://purl.obolibrary.org/obo/CL_1000478	transitional myocyte of sinoatrial node	http://purl.obolibrary.org/obo/CL_1000409	myocyte of sinoatrial node		A transitional myocyte that is part of the sinoatrial node.
http://purl.obolibrary.org/obo/CL_1000479	Purkinje myocyte of atrioventricular node	http://purl.obolibrary.org/obo/CL_1000410	myocyte of atrioventricular node		A Purkinje myocyte that is part of the atrioventricular node.
http://purl.obolibrary.org/obo/CL_1000482	myocardial endocrine cell of interventricular septum	http://purl.obolibrary.org/obo/CL_2000022	cardiac septum cell		A myocardial endocrine cell that is part of the interventricular septum.
http://purl.obolibrary.org/obo/CL_1000487	smooth muscle cell of prostate	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell that is part of the prostate gland.
http://purl.obolibrary.org/obo/CL_1000488	cholangiocyte	http://purl.obolibrary.org/obo/CL_0000069	branched duct epithelial cell		An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.
http://purl.obolibrary.org/obo/CL_1000490	mesothelial cell of peritoneum	http://purl.obolibrary.org/obo/CL_0000077	mesothelial cell		A mesothelial cell that is part of the peritoneum.
http://purl.obolibrary.org/obo/CL_1000491	mesothelial cell of pleura	http://purl.obolibrary.org/obo/CL_0000077	mesothelial cell		A mesothelial cell that is part of the pleura.
http://purl.obolibrary.org/obo/CL_1000492	mesothelial cell of parietal pleura	http://purl.obolibrary.org/obo/CL_1000491	mesothelial cell of pleura		A mesothelial cell that is part of the parietal pleura.
http://purl.obolibrary.org/obo/CL_1000493	mesothelial cell of visceral pleura	http://purl.obolibrary.org/obo/CL_1000491	mesothelial cell of pleura		A mesothelial cell that is part of the visceral pleura.
http://purl.obolibrary.org/obo/CL_1000494	nephron tubule epithelial cell	http://purl.obolibrary.org/obo/CL_1000507	kidney tubule cell		An epithelial cell that is part of a nephron tubule.
http://purl.obolibrary.org/obo/CL_1000495	small intestine goblet cell	http://purl.obolibrary.org/obo/CL_1001598	small intestine secretory cell		A goblet cell that is part of the small intestine.
http://purl.obolibrary.org/obo/CL_1000497	kidney cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		A cell that is part of a kidney.
http://purl.obolibrary.org/obo/CL_1000500	kidney interstitial cell	http://purl.obolibrary.org/obo/CL_1000497	kidney cell		A cell that is part of kidney interstitium.
http://purl.obolibrary.org/obo/CL_1000504	kidney medulla cell	http://purl.obolibrary.org/obo/CL_1000497	kidney cell		A cell that is part of a renal medulla.
http://purl.obolibrary.org/obo/CL_1000505	kidney pelvis cell	http://purl.obolibrary.org/obo/CL_1000497	kidney cell		A cell that is part of a renal pelvis.
http://purl.obolibrary.org/obo/CL_1000507	kidney tubule cell	http://purl.obolibrary.org/obo/CL_1000497	kidney cell		A cell that is part of a nephron tubule.
http://purl.obolibrary.org/obo/CL_1000510	kidney glomerular epithelial cell	http://purl.obolibrary.org/obo/CL_1000746	glomerular cell		Any kidney epithelial cell that is part of some glomerular epithelium.
http://purl.obolibrary.org/obo/CL_1000546	kidney medulla collecting duct epithelial cell	http://purl.obolibrary.org/obo/CL_1000504	kidney medulla cell		An epithelial cell that is part of a renal medulla collecting duct.
http://purl.obolibrary.org/obo/CL_1000547	kidney inner medulla collecting duct epithelial cell	http://purl.obolibrary.org/obo/CL_1000617	kidney inner medulla cell		An epithelial cell that is part of some inner medullary collecting duct.
http://purl.obolibrary.org/obo/CL_1000549	kidney cortex collecting duct epithelial cell	http://purl.obolibrary.org/obo/CL_1000454	kidney collecting duct epithelial cell		An epithelial cell that is part of a cortical collecting duct.
http://purl.obolibrary.org/obo/CL_1000600	lower urinary tract cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any cell that is part of some lower urinary tract.
http://purl.obolibrary.org/obo/CL_1000601	ureteral cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any cell that is part of some ureter.
http://purl.obolibrary.org/obo/CL_1000606	kidney nerve cell	http://purl.obolibrary.org/obo/CL_2000032	peripheral nervous system neuron		Any neuron that has its soma located in some kidney.
http://purl.obolibrary.org/obo/CL_1000612	kidney corpuscule cell	http://purl.obolibrary.org/obo/CL_1000449	epithelial cell of nephron		Any renal cortical epithelial cell that is part of some renal corpuscle.
http://purl.obolibrary.org/obo/CL_1000617	kidney inner medulla cell	http://purl.obolibrary.org/obo/CL_1000504	kidney medulla cell		Any kidney medulla cell that is part of some inner medulla of kidney.
http://purl.obolibrary.org/obo/CL_1000681	kidney cortex interstitial cell	http://purl.obolibrary.org/obo/CL_1000500	kidney interstitial cell		A cell that is part of an interstitial compartment of a renal cortex.
http://purl.obolibrary.org/obo/CL_1000682	kidney medulla interstitial cell	http://purl.obolibrary.org/obo/CL_1000504	kidney medulla cell		A cell that is part of an interstitum of a renal medulla.
http://purl.obolibrary.org/obo/CL_1000692	kidney interstitial fibroblast	http://purl.obolibrary.org/obo/CL_1000500	kidney interstitial cell		A fibroblast that is part of an interstitial compartment of a kidney.
http://purl.obolibrary.org/obo/CL_1000702	kidney pelvis smooth muscle cell	http://purl.obolibrary.org/obo/CL_1000505	kidney pelvis cell		Any smooth muscle cell that is part of some kidney pelvis smooth muscle.
http://purl.obolibrary.org/obo/CL_1000708	ureter adventitial cell	http://purl.obolibrary.org/obo/CL_1000601	ureteral cell		Any ureteral cell that is part of some adventitia of ureter.
http://purl.obolibrary.org/obo/CL_1000714	kidney cortex collecting duct principal cell	http://purl.obolibrary.org/obo/CL_1001431	kidney collecting duct principal cell		Any renal principal cell that is part of some cortical collecting duct.
http://purl.obolibrary.org/obo/CL_1000718	kidney inner medulla collecting duct principal cell	http://purl.obolibrary.org/obo/CL_1001431	kidney collecting duct principal cell		Any renal principal cell that is part of some inner medullary collecting duct.
http://purl.obolibrary.org/obo/CL_1000746	glomerular cell	http://purl.obolibrary.org/obo/CL_1000612	kidney corpuscule cell		Any kidney corpuscule cell that is part of some renal glomerulus.
http://purl.obolibrary.org/obo/CL_1000803	kidney inner medulla interstitial cell	http://purl.obolibrary.org/obo/CL_1000682	kidney medulla interstitial cell		A cell that is part of an interstitial compartment of an inner renal medulla.
http://purl.obolibrary.org/obo/CL_1000854	kidney blood vessel cell	http://purl.obolibrary.org/obo/CL_1000504	kidney medulla cell		A blood vessel cell that is part of a kidney.
http://purl.obolibrary.org/obo/CL_1000891	kidney arterial blood vessel cell	http://purl.obolibrary.org/obo/CL_1000854	kidney blood vessel cell		Any kidney blood vessel cell that is part of some kidney arterial blood vessel.
http://purl.obolibrary.org/obo/CL_1000892	kidney capillary endothelial cell	http://purl.obolibrary.org/obo/CL_1000854	kidney blood vessel cell		An endothelial cell that is part of the capillary of the kidney.
http://purl.obolibrary.org/obo/CL_1000893	kidney venous blood vessel cell	http://purl.obolibrary.org/obo/CL_1000854	kidney blood vessel cell		Any kidney blood vessel cell that is part of some renal vein.
http://purl.obolibrary.org/obo/CL_1000979	ureter smooth muscle cell	http://purl.obolibrary.org/obo/CL_1000601	ureteral cell		Any smooth muscle cell that is part of some muscular coat of ureter.
http://purl.obolibrary.org/obo/CL_1001005	glomerular capillary endothelial cell	http://purl.obolibrary.org/obo/CL_1000892	kidney capillary endothelial cell		An endothelial cell that is part of the glomerular capillary of the kidney.
http://purl.obolibrary.org/obo/CL_1001006	kidney afferent arteriole cell	http://purl.obolibrary.org/obo/CL_1000891	kidney arterial blood vessel cell		An endothelial cell which is part of the afferent arteriole in the kidney. This cell is  responsible for maintaining renal blood flow and glomerular filtration rate.
http://purl.obolibrary.org/obo/CL_1001045	kidney cortex artery cell	http://purl.obolibrary.org/obo/CL_1000891	kidney arterial blood vessel cell		Any kidney arterial blood vessel cell that is part of some renal cortex artery.
http://purl.obolibrary.org/obo/CL_1001052	kidney cortex vein cell	http://purl.obolibrary.org/obo/CL_1000893	kidney venous blood vessel cell		Any kidney venous blood vessel cell that is part of some renal cortex vein.
http://purl.obolibrary.org/obo/CL_1001096	kidney afferent arteriole endothelial cell	http://purl.obolibrary.org/obo/CL_1001006	kidney afferent arteriole cell		An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration.
http://purl.obolibrary.org/obo/CL_1001097	kidney afferent arteriole smooth muscle cell	http://purl.obolibrary.org/obo/CL_0008035	microcirculation associated smooth muscle cell		A smooth muscle cell found in the wall of the afferent arteriole. This cell contracts and relaxes in response to changes in blood pressure, a process known as a myogenic response, to alter artery diameter and regulate blood flow into the glomeruli.
http://purl.obolibrary.org/obo/CL_1001135	arcuate artery cell	http://purl.obolibrary.org/obo/CL_1001045	kidney cortex artery cell		Any kidney cortex artery cell that is part of some kidney arcuate artery.
http://purl.obolibrary.org/obo/CL_1001138	interlobular artery cell	http://purl.obolibrary.org/obo/CL_1001045	kidney cortex artery cell		Any kidney cortex artery cell that is part of some interlobular artery.
http://purl.obolibrary.org/obo/CL_1001213	arcuate artery endothelial cell	http://purl.obolibrary.org/obo/CL_1001135	arcuate artery cell		Any endothelial cell that is part of some kidney arcuate artery.
http://purl.obolibrary.org/obo/CL_1001214	arcuate artery smooth muscle cell	http://purl.obolibrary.org/obo/CL_1001135	arcuate artery cell		Any smooth muscle cell that is part of some kidney arcuate artery.
http://purl.obolibrary.org/obo/CL_1001216	interlobulary artery endothelial cell	http://purl.obolibrary.org/obo/CL_1001138	interlobular artery cell		Any endothelial cell that is part of some interlobular artery.
http://purl.obolibrary.org/obo/CL_1001217	interlobulary artery smooth muscle cell	http://purl.obolibrary.org/obo/CL_1001138	interlobular artery cell		Any smooth muscle cell that is part of some interlobular artery.
http://purl.obolibrary.org/obo/CL_1001225	kidney collecting duct cell	http://purl.obolibrary.org/obo/CL_1000497	kidney cell		A cell that is part of a collecting duct of renal tubule.
http://purl.obolibrary.org/obo/CL_1001318	renal interstitial pericyte	http://purl.obolibrary.org/obo/CL_1000500	kidney interstitial cell		A pericyte cell located in the kidney interstitium.
http://purl.obolibrary.org/obo/CL_1001319	bladder cell	http://purl.obolibrary.org/obo/CL_1000600	lower urinary tract cell		Any cell that is part of some urinary bladder.
http://purl.obolibrary.org/obo/CL_1001320	urethra cell	http://purl.obolibrary.org/obo/CL_1000600	lower urinary tract cell		Any cell that is part of some urethra.
http://purl.obolibrary.org/obo/CL_1001431	kidney collecting duct principal cell	http://purl.obolibrary.org/obo/CL_1000454	kidney collecting duct epithelial cell		Any renal principal cell that is part of some collecting duct of renal tubule.
http://purl.obolibrary.org/obo/CL_1001433	epithelial cell of exocrine pancreas	http://purl.obolibrary.org/obo/CL_0000083	epithelial cell of pancreas		An epithelial cell of the exocrine pancreas.
http://purl.obolibrary.org/obo/CL_1001434	olfactory bulb interneuron	http://purl.obolibrary.org/obo/CL_0000101	sensory neuron		A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons
http://purl.obolibrary.org/obo/CL_1001502	mitral cell	http://purl.obolibrary.org/obo/CL_1001434	olfactory bulb interneuron		The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex.
http://purl.obolibrary.org/obo/CL_1001503	olfactory bulb tufted cell	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala.
http://purl.obolibrary.org/obo/CL_1001516	intestinal enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0002563	intestinal epithelial cell		The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.
http://purl.obolibrary.org/obo/CL_1001517	stomach enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0002178	epithelial cell of stomach		The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach.
http://purl.obolibrary.org/obo/CL_1001567	lung endothelial cell	http://purl.obolibrary.org/obo/CL_0002139	endothelial cell of vascular tree		Any endothelial cell of vascular tree that is part of some lung.
http://purl.obolibrary.org/obo/CL_1001568	pulmonary artery endothelial cell	http://purl.obolibrary.org/obo/CL_1000413	endothelial cell of artery		Any endothelial cell of vascular tree that is part of some pulmonary artery.
http://purl.obolibrary.org/obo/CL_1001569	hippocampal interneuron	http://purl.obolibrary.org/obo/CL_0002608	hippocampal neuron		An interneuron with a soma found in the hippocampus.
http://purl.obolibrary.org/obo/CL_1001572	colon endothelial cell	http://purl.obolibrary.org/obo/CL_0000131	gut endothelial cell		A vascular endothelial cell found in colon blood vessels.
http://purl.obolibrary.org/obo/CL_1001573	nasopharyngeal epithelial cell	http://purl.obolibrary.org/obo/CL_0002631	epithelial cell of upper respiratory tract		Cell of the nasopharyngeal epithelium.
http://purl.obolibrary.org/obo/CL_1001575	uterine cervix squamous cell	http://purl.obolibrary.org/obo/CL_0002535	epithelial cell of cervix		Squamous cell of uterine cervix epithelium.
http://purl.obolibrary.org/obo/CL_1001576	oral mucosa squamous cell	http://purl.obolibrary.org/obo/CL_0002251	epithelial cell of alimentary canal		Squamous cell of oral epithelium.
http://purl.obolibrary.org/obo/CL_1001577	tonsil squamous cell	http://purl.obolibrary.org/obo/CL_0002251	epithelial cell of alimentary canal		Squamous cell of tonsil epithelium.
http://purl.obolibrary.org/obo/CL_1001578	vagina squamous cell	http://purl.obolibrary.org/obo/CL_0000240	stratified squamous epithelial cell		Squamous cell of vaginal epithelium.
http://purl.obolibrary.org/obo/CL_1001579	cerebral cortex glial cell	http://purl.obolibrary.org/obo/CL_0000125	glial cell		Glial cell of cerebral cortex.
http://purl.obolibrary.org/obo/CL_1001580	hippocampal glial cell	http://purl.obolibrary.org/obo/CL_1001579	cerebral cortex glial cell		A glial cell that is part of the hippocampus.
http://purl.obolibrary.org/obo/CL_1001581	lateral ventricle glial cell	http://purl.obolibrary.org/obo/CL_0000125	glial cell		Glial cell of lateral ventricle.
http://purl.obolibrary.org/obo/CL_1001582	lateral ventricle neuron	http://purl.obolibrary.org/obo/CL_0012001	neuron of the forebrain		Neuron of lateral ventricle.
http://purl.obolibrary.org/obo/CL_1001586	mammary gland glandular cell	http://purl.obolibrary.org/obo/CL_0002327	mammary gland epithelial cell		Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts.
http://purl.obolibrary.org/obo/CL_1001587	uterine cervix secretory cell	http://purl.obolibrary.org/obo/CL_1001591	oviduct secretory cell		Glandular cell of uterine cervix epithelium.
http://purl.obolibrary.org/obo/CL_1001588	colon glandular cell	http://purl.obolibrary.org/obo/CL_0011108	colon epithelial cell		Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.
http://purl.obolibrary.org/obo/CL_1001589	duodenum secretory cell	http://purl.obolibrary.org/obo/CL_1001598	small intestine secretory cell		Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell.
http://purl.obolibrary.org/obo/CL_1001590	epididymis secretory cell	http://purl.obolibrary.org/obo/CL_0000068	duct epithelial cell		Glandular cell of epididymal epithelium.
http://purl.obolibrary.org/obo/CL_1001591	oviduct secretory cell	http://purl.obolibrary.org/obo/CL_1100001	secretory epithelial cell		Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells.
http://purl.obolibrary.org/obo/CL_1001592	gallbladder glandular cell	http://purl.obolibrary.org/obo/CL_1000415	epithelial cell of gallbladder		Glandular cell of gallbladder epithelium.
http://purl.obolibrary.org/obo/CL_1001593	parathyroid glandular cell	http://purl.obolibrary.org/obo/CL_0002260	epithelial cell of parathyroid gland		Glandular (secretory) cell of parathyroid epithelium.
http://purl.obolibrary.org/obo/CL_1001595	rectum glandular cell	http://purl.obolibrary.org/obo/CL_0002658	glandular cell of the large intestine		Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells.
http://purl.obolibrary.org/obo/CL_1001596	salivary gland glandular cell	http://purl.obolibrary.org/obo/CL_0009005	salivary gland cell		Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts.
http://purl.obolibrary.org/obo/CL_1001597	seminal vesicle glandular cell	http://purl.obolibrary.org/obo/CL_0000150	glandular secretory epithelial cell		Glandular cell of seminal vesicle epithelium.
http://purl.obolibrary.org/obo/CL_1001598	small intestine secretory cell	http://purl.obolibrary.org/obo/CL_0002254	epithelial cell of small intestine		A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) .
http://purl.obolibrary.org/obo/CL_1001599	pancreas exocrine glandular cell	http://purl.obolibrary.org/obo/CL_1001433	epithelial cell of exocrine pancreas		Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts.
http://purl.obolibrary.org/obo/CL_1001601	adrenal gland glandular cell	http://purl.obolibrary.org/obo/CL_0000150	glandular secretory epithelial cell		Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens.
http://purl.obolibrary.org/obo/CL_1001602	cerebral cortex endothelial cell	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex.
http://purl.obolibrary.org/obo/CL_1001603	lung macrophage	http://purl.obolibrary.org/obo/CL_0000235	macrophage		Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.
http://purl.obolibrary.org/obo/CL_1001606	foreskin keratinocyte	http://purl.obolibrary.org/obo/CL_0000312	keratinocyte		Keratinocyte from foreskin.
http://purl.obolibrary.org/obo/CL_1001607	articular chondrocyte	http://purl.obolibrary.org/obo/CL_0000138	chondrocyte		Chondrocyte forming the hyaline cartilage found in joints.
http://purl.obolibrary.org/obo/CL_1001608	foreskin fibroblast	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		Fibroblast from foreskin.
http://purl.obolibrary.org/obo/CL_1001609	muscle fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		Fibroblast from muscle organ.
http://purl.obolibrary.org/obo/CL_1001610	bone marrow hematopoietic cell	http://purl.obolibrary.org/obo/CL_0002092	bone marrow cell		Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.
http://purl.obolibrary.org/obo/CL_1001611	cerebellar neuron	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		Neuron of the cerebellum.
http://purl.obolibrary.org/obo/CL_2000000	epidermal melanocyte	http://purl.obolibrary.org/obo/CL_1000458	melanocyte of skin		Any melanocyte that is part of a epidermis.
http://purl.obolibrary.org/obo/CL_2000001	peripheral blood mononuclear cell	http://purl.obolibrary.org/obo/CL_0000842	mononuclear leukocyte		A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.
http://purl.obolibrary.org/obo/CL_2000002	decidual cell	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization.
http://purl.obolibrary.org/obo/CL_2000004	pituitary gland cell	http://purl.obolibrary.org/obo/CL_0002319	neural cell		Any cell that is part of a pituitary gland.
http://purl.obolibrary.org/obo/CL_2000005	brain macroglial cell	http://purl.obolibrary.org/obo/CL_0000126	macroglial cell		Any macroglial cell that is part of a brain.
http://purl.obolibrary.org/obo/CL_2000006	tonsil germinal center B cell	http://purl.obolibrary.org/obo/CL_0000844	germinal center B cell		Any germinal center B cell that is part of a tonsil.
http://purl.obolibrary.org/obo/HP_0000023	Inguinal hernia	http://purl.obolibrary.org/obo/HP_0004299	Hernia of the abdominal wall		Protrusion of the contents of the abdominal cavity through the inguinal canal.
http://purl.obolibrary.org/obo/HP_0000031	Epididymitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		The presence of inflammation of the epididymis.
http://purl.obolibrary.org/obo/HP_0000083	Renal insufficiency	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism.
http://purl.obolibrary.org/obo/HP_0000090	Nephronophthisis	http://purl.obolibrary.org/obo/HP_0100957	Abnormal renal medulla morphology		Presence of cysts at the corticomedullary junction of the kidney in combination with tubulointerstitial fibrosis.
http://purl.obolibrary.org/obo/HP_0000093	Proteinuria	http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level		Increased levels of protein in the urine.
http://purl.obolibrary.org/obo/HP_0000132	Menorrhagia	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.
http://purl.obolibrary.org/obo/HP_0000238	Hydrocephalus	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		Hydrocephalus is an active distension of the ventricular system of the brain resulting from inadequate passage of CSF from its point of production within the cerebral ventricles to its point of absorption into the systemic circulation.
http://purl.obolibrary.org/obo/HP_0000252	Microcephaly	http://purl.obolibrary.org/obo/HP_0040195	Decreased head circumference		Head circumference below 2 standard deviations below the mean for age and gender.
http://purl.obolibrary.org/obo/HP_0000265	Mastoiditis	http://purl.obolibrary.org/obo/HP_0000264	Abnormal mastoid morphology		Infection of the mastoid air cells, arising as a complication of otitis media or occurring in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face	http://purl.obolibrary.org/obo/HP_0000234	Abnormality of the head		An abnormality of the face.
http://purl.obolibrary.org/obo/HP_0000272	Malar flattening	http://purl.obolibrary.org/obo/HP_0010668	Abnormal zygomatic bone morphology		Underdevelopment of the malar prominence of the jugal bone (zygomatic bone in mammals), appreciated in profile, frontal view, and/or by palpation.
http://purl.obolibrary.org/obo/HP_0000275	Narrow face	http://purl.obolibrary.org/obo/HP_0000274	Small face		Bizygomatic (upper face) and bigonial (lower face) width are both more than 2 standard deviations below the mean (objective); or, an apparent reduction in the width of the upper and lower face (subjective).
http://purl.obolibrary.org/obo/HP_0000278	Retrognathia	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		An abnormality in which the mandible is mislocalised posteriorly.
http://purl.obolibrary.org/obo/HP_0000347	Micrognathia	http://purl.obolibrary.org/obo/HP_0009118	Aplasia/Hypoplasia of the mandible		Developmental hypoplasia of the mandible.
http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment	http://purl.obolibrary.org/obo/HP_0000364	Hearing abnormality		A decreased magnitude of the sensory perception of sound.
http://purl.obolibrary.org/obo/HP_0000405	Conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		An abnormality of vibrational conductance of sound to the inner ear leading to impairment of sensory perception of sound.
http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlear nerve.
http://purl.obolibrary.org/obo/HP_0000421	Epistaxis	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.
http://purl.obolibrary.org/obo/HP_0000491	Keratitis	http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye		Inflammation of the cornea.
http://purl.obolibrary.org/obo/HP_0000508	Ptosis	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective).
http://purl.obolibrary.org/obo/HP_0000509	Conjunctivitis	http://purl.obolibrary.org/obo/HP_0025337	Red eye		Inflammation of the conjunctiva.
http://purl.obolibrary.org/obo/HP_0000526	Aniridia	http://purl.obolibrary.org/obo/HP_0008053	Aplasia/Hypoplasia of the iris		Abnormality of the iris characterized by, typically bilateral, complete or partial iris hypoplasia. The phenotype ranges from mild defects of anterior iris stroma only to almost complete absence of the iris.
http://purl.obolibrary.org/obo/HP_0000554	Uveitis	http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye		Inflammation of one or all portions of the uveal tract.
http://purl.obolibrary.org/obo/HP_0000556	Retinal dystrophy	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Retinal dystrophy is an abnormality of the retina associated with a hereditary process. Retinal dystrophies are defined by their predominantly monogenic inheritance and they are frequently associated with loss or dysfunction of photoreceptor cells as a primary or secondary event.
http://purl.obolibrary.org/obo/HP_0000572	Visual loss	http://purl.obolibrary.org/obo/HP_0000505	Visual impairment		Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise the term reduced visual acuity should be used (or a subclass of that).
http://purl.obolibrary.org/obo/HP_0000608	Macular degeneration	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells of the macula lutea.
http://purl.obolibrary.org/obo/HP_0000613	Photophobia	http://purl.obolibrary.org/obo/HP_5200058	Sensory hypersensitivity		Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
http://purl.obolibrary.org/obo/HP_0000618	Blindness	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		Blindness is the condition of lacking visual perception defined as a profound reduction in visual perception. On the 6m visual acuity scale, blindness is defined as less than 3/60. On the 20ft visual acuity scale, blindness is defined as less than 20/400. On the decimal visual acuity scale, blindness is defined as less than 0.05. Blindness is typically characterized by a visual field of no greater than 10 degrees in radius around central fixation.
http://purl.obolibrary.org/obo/HP_0000622	Blurred vision	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Lack of sharpness of vision resulting in the inability to see fine detail.
http://purl.obolibrary.org/obo/HP_0000648	Optic atrophy	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy.
http://purl.obolibrary.org/obo/HP_0000651	Diplopia	http://purl.obolibrary.org/obo/HP_0011514	Abnormality of binocular vision		Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.
http://purl.obolibrary.org/obo/HP_0000668	Hypodontia	http://purl.obolibrary.org/obo/HP_0009804	Tooth agenesis		The absence of five or less teeth from the normal series by a failure to develop.
http://purl.obolibrary.org/obo/HP_0000707	Abnormality of the nervous system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An abnormality of the nervous system.
http://purl.obolibrary.org/obo/HP_0000713	Agitation	http://purl.obolibrary.org/obo/HP_5200263	Abnormally increased volition		A state of excessive motor activity that is associated with mental distress or a feeling of substantial unease or inner tension. Distinguished from restlessness by the increased level of emotional distress and negative intensity of the experience. Agitation has a significant level of physical activity that is typically threatening to the self or others.
http://purl.obolibrary.org/obo/HP_0000737	Irritability	http://purl.obolibrary.org/obo/HP_0031467	Dysregulated negative emotional state		An emotional state characterized by negative feelings of heightened frustration, annoyance, or feeling upset, often triggered by internal factors (e.g., fatigue, hunger, unfulfilled desires) or external factors (e.g., social or environmental challenges). Irritability may be unpredictable, and is accompanied by a lowered threshold for emotional reactivity and observable features (speech, facial expressions, or psychomotor activity).
http://purl.obolibrary.org/obo/HP_0000739	Anxiety	http://purl.obolibrary.org/obo/HP_5200230	Maladaptive fear-related cognitions		Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses. There is worry about the negative effects of past unpleasant experiences and future negative possibilities. Individuals may feel fearful, apprehensive, or threatened by uncertainty, and they may also have fears of falling apart or losing control.
http://purl.obolibrary.org/obo/HP_0000741	Apathy	http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition		Apathy is a quantitative reduction of interest, motivation and the initiation and persistence of goal-directed behavior, where often the accompanying emotions, thoughts, and social interactions are also diminished. The individual is typically non-reactive to provocations, positive or negative, and appears to not care. Distinguished from lethargy which involves lack of physical or mental energy.
http://purl.obolibrary.org/obo/HP_0000750	Delayed speech and language development	http://purl.obolibrary.org/obo/HP_0012758	Neurodevelopmental delay		A degree of language development that is significantly below the norm for a child of a specified age.
http://purl.obolibrary.org/obo/HP_0000768	Pectus carinatum	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		A deformity of the chest caused by overgrowth of the ribs and characterized by protrusion of the sternum.
http://purl.obolibrary.org/obo/HP_0000774	Narrow chest	http://purl.obolibrary.org/obo/HP_0005257	Thoracic hypoplasia		Reduced width of the chest from side to side, associated with a reduced distance from the sternal notch to the tip of the shoulder.
http://purl.obolibrary.org/obo/HP_0000777	Abnormal thymus morphology	http://purl.obolibrary.org/obo/HP_0100763	Abnormality of the lymphatic system		Abnormality of the thymus, an organ located in the upper anterior portion of the chest cavity just behind the sternum and whose main function is to provide an environment for T lymphocyte maturation.
http://purl.obolibrary.org/obo/HP_0000790	Hematuria	http://purl.obolibrary.org/obo/HP_0012614	Abnormal urine cytology		The presence of blood in the urine. Hematuria may be gross hematuria (visible to the naked eye) or microscopic hematuria (detected by dipstick or microscopic examination of the urine).
http://purl.obolibrary.org/obo/HP_0000802	Impotence	http://purl.obolibrary.org/obo/HP_0100639	Erectile dysfunction		Inability to develop or maintain an erection of the penis.
http://purl.obolibrary.org/obo/HP_0000819	Diabetes mellitus	http://purl.obolibrary.org/obo/HP_0001952	Glucose intolerance		A group of abnormalities characterized by hyperglycemia and glucose intolerance.
http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the skeletal system	http://purl.obolibrary.org/obo/HP_0033127	Abnormality of the musculoskeletal system		An abnormality of the skeletal system.
http://purl.obolibrary.org/obo/HP_0000926	Platyspondyly	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		A flattened vertebral body shape with reduced distance between the vertebral endplates.
http://purl.obolibrary.org/obo/HP_0000952	Jaundice	http://purl.obolibrary.org/obo/HP_0001396	Cholestasis		Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.
http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		Hyperkeratosis is a histopathological term defining a thickened stratum corneum and may be present in many different skin conditions, with many possible overlaps. Hyperkeratosis refers to the increased thickness of the stratum corneum, the outer layer of the skin. Hyperkeratosis is subclassified as orthokeratotic or parakeratotic. Orthokeratotic hyperkeratosis refers to the thickening of the keratin layer with preserved keratinocyte maturation, while parakeratotic hyperkeratosis shows retained nuclei as a sign of delayed maturation of keratinocytes.
http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces.
http://purl.obolibrary.org/obo/HP_0000967	Petechiae	http://purl.obolibrary.org/obo/HP_0031365	Macular purpura		Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae.
http://purl.obolibrary.org/obo/HP_0000969	Edema	http://purl.obolibrary.org/obo/HP_0011032	Abnormality of fluid regulation		An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0010765	Palmar hyperkeratosis		Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot.
http://purl.obolibrary.org/obo/HP_0000975	Hyperhidrosis	http://purl.obolibrary.org/obo/HP_0007550	Hypohidrosis or hyperhidrosis		Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.
http://purl.obolibrary.org/obo/HP_0000978	Bruising susceptibility	http://purl.obolibrary.org/obo/HP_0001933	Subcutaneous hemorrhage		An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.
http://purl.obolibrary.org/obo/HP_0000988	Skin rash	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		A red eruption of the skin.
http://purl.obolibrary.org/obo/HP_0000989	Pruritus	http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology		Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.
http://purl.obolibrary.org/obo/HP_0000999	Pyoderma	http://purl.obolibrary.org/obo/HP_0005406	Recurrent bacterial skin infections		Any manifestation of a skin disease associated with the production of pus.
http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		An abnormality of the pigmentation of the skin.
http://purl.obolibrary.org/obo/HP_0001004	Lymphedema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Localized fluid retention and tissue swelling caused by a compromised lymphatic system.
http://purl.obolibrary.org/obo/HP_0001022	Albinism	http://purl.obolibrary.org/obo/HP_0007513	Generalized hypopigmentation		An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina).
http://purl.obolibrary.org/obo/HP_0001025	Urticaria	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.
http://purl.obolibrary.org/obo/HP_0001159	Syndactyly	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		Webbing or fusion of the fingers or toes, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers or toes in a proximo-distal axis are referred to as "symphalangism".
http://purl.obolibrary.org/obo/HP_0001249	Intellectual disability	http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental abnormality		The term intellectual disability or intellectual developmental disorder is used to describe significantly sub-average intellectual and adaptive functioning based on clinical assessment and as measured by individually administered, appropriately normed, standardized and validated tests of intellectual functioning and adaptive behavior, with onset during the developmental period from infancy through adolescence.
http://purl.obolibrary.org/obo/HP_0001250	Seizure	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.
http://purl.obolibrary.org/obo/HP_0001252	Hypotonia	http://purl.obolibrary.org/obo/HP_0003808	Abnormal muscle tone		Hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle). Even when relaxed, muscles have a continuous and passive partial contraction which provides some resistance to passive stretching. Hypotonia thus manifests as diminished resistance to passive stretching. Hypotonia is not the same as muscle weakness, although the two conditions can co-exist.
http://purl.obolibrary.org/obo/HP_0001254	Lethargy	http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition		A state of fatigue, either physical or mental slowness and sluggishness, with difficulties in initiating or performing simple tasks. Distinguished from apathy which implies indifference and a lack of desire or interest in the task. A person with lethargy may have the desire, but not the energy to engage in personal or socially relevant tasks.
http://purl.obolibrary.org/obo/HP_0001259	Coma	http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness		The complete absence of wakefulness and consciousness, which is evident through a lack of response to any form of external stimuli.
http://purl.obolibrary.org/obo/HP_0001260	Dysarthria	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.
http://purl.obolibrary.org/obo/HP_0001262	Excessive daytime somnolence	http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness		A state of abnormally strong desire for sleep during the daytime.
http://purl.obolibrary.org/obo/HP_0001269	Hemiparesis	http://purl.obolibrary.org/obo/HP_0004374	Hemiplegia/hemiparesis		Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength.
http://purl.obolibrary.org/obo/HP_0001276	Hypertonia	http://purl.obolibrary.org/obo/HP_0003808	Abnormal muscle tone		A condition in which there is increased muscle tone so that arms or legs, for example, are stiff and difficult to move.
http://purl.obolibrary.org/obo/HP_0001287	Meningitis	http://purl.obolibrary.org/obo/HP_0011450	Unusual CNS infection		Inflammation of the meninges.
http://purl.obolibrary.org/obo/HP_0001289	Confusion	http://purl.obolibrary.org/obo/HP_0100543	Cognitive impairment		Lack of clarity and coherence of thought, perception, understanding, or action.
http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		Reduced strength of muscles.
http://purl.obolibrary.org/obo/HP_0001363	Craniosynostosis	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		Craniosynostosis refers to the premature closure of the cranial sutures. Primary craniosynostosis refers to the closure of one or more sutures due to abnormalities in skull development, and secondary craniosynostosis results from failure of brain growth.
http://purl.obolibrary.org/obo/HP_0001369	Arthritis	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		Inflammation of a joint.
http://purl.obolibrary.org/obo/HP_0001370	Rheumatoid arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures.
http://purl.obolibrary.org/obo/HP_0001373	Joint dislocation	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		Displacement or malalignment of joints.
http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness	http://purl.obolibrary.org/obo/HP_0001376	Limitation of joint mobility		Joint stiffness is a perceived sensation of tightness in a joint or joints when attempting to move them after a period of inactivity. Joint stiffness typically subsides over time.
http://purl.obolibrary.org/obo/HP_0001433	Hepatosplenomegaly	http://purl.obolibrary.org/obo/HP_0001744	Splenomegaly		Simultaneous enlargement of the liver and spleen.
http://purl.obolibrary.org/obo/HP_0001480	Freckling	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		The presence of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin.
http://purl.obolibrary.org/obo/HP_0001482	Subcutaneous nodule	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		Slightly elevated lesions on or in the skin with a diameter of over 5 mm.
http://purl.obolibrary.org/obo/HP_0001508	Failure to thrive	http://purl.obolibrary.org/obo/HP_0004325	Decreased body weight		Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.
http://purl.obolibrary.org/obo/HP_0001510	Growth delay	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		A deficiency or slowing down of growth pre- and postnatally.
http://purl.obolibrary.org/obo/HP_0001513	Obesity	http://purl.obolibrary.org/obo/HP_0004324	Increased body weight		Accumulation of substantial excess body fat.
http://purl.obolibrary.org/obo/HP_0001548	Overgrowth	http://purl.obolibrary.org/obo/HP_0000098	Tall stature		Excessive postnatal growth which may comprise increased weight, increased length, and/or increased head circumference.
http://purl.obolibrary.org/obo/HP_0001596	Alopecia	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		A noncongenital process of hair loss, which may progress to partial or complete baldness.
http://purl.obolibrary.org/obo/HP_0001609	Hoarse voice	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.
http://purl.obolibrary.org/obo/HP_0001618	Dysphonia	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		Difficulty in speaking due to a physical disorder of the mouth, tongue, throat, or vocal cords. Associated with a known physical or neurological cause.
http://purl.obolibrary.org/obo/HP_0001649	Tachycardia	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		A rapid heartrate that exceeds the range of the normal resting heartrate for age.
http://purl.obolibrary.org/obo/HP_0001650	Aortic valve stenosis	http://purl.obolibrary.org/obo/HP_0031652	Abnormal aortic valve physiology		The presence of a stenosis (narrowing) of the aortic valve.
http://purl.obolibrary.org/obo/HP_0001733	Pancreatitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		The presence of inflammation in the pancreas.
http://purl.obolibrary.org/obo/HP_0001744	Splenomegaly	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Abnormal increased size of the spleen.
http://purl.obolibrary.org/obo/HP_0001762	Talipes equinovarus	http://purl.obolibrary.org/obo/HP_0001883	Talipes		Talipes equinovarus (also called clubfoot) typically has four main components: inversion and adduction of the forefoot; inversion of the heel and hindfoot; equinus (limitation of extension) of the ankle and subtalar joint; and internal rotation of the leg.
http://purl.obolibrary.org/obo/HP_0001789	Hydrops fetalis	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema.
http://purl.obolibrary.org/obo/HP_0001824	Weight loss	http://purl.obolibrary.org/obo/HP_0004325	Decreased body weight		Reduction of total body weight.
http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia	http://purl.obolibrary.org/obo/HP_0011873	Abnormal platelet count		A reduction in the number of circulating thrombocytes.
http://purl.obolibrary.org/obo/HP_0001876	Pancytopenia	http://purl.obolibrary.org/obo/HP_0012145	Abnormality of multiple cell lineages in the bone marrow		An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets).
http://purl.obolibrary.org/obo/HP_0001880	Increased total eosinophil count	http://purl.obolibrary.org/obo/HP_0020064	Abnormal total eosinophil count		Increased count of eosinophils in the blood.
http://purl.obolibrary.org/obo/HP_0001882	Decreased total leukocyte count	http://purl.obolibrary.org/obo/HP_0011893	Abnormal leukocyte count		An abnormal decreased number of leukocytes in the blood.
http://purl.obolibrary.org/obo/HP_0001888	Decreased total lymphocyte count	http://purl.obolibrary.org/obo/HP_0040088	Abnormal lymphocyte count		A reduced number of lymphocytes in the blood.
http://purl.obolibrary.org/obo/HP_0001889	Megaloblastic anemia	http://purl.obolibrary.org/obo/HP_0001972	Macrocytic anemia		Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts).
http://purl.obolibrary.org/obo/HP_0001903	Anemia	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		A reduction in erythrocytes volume or hemoglobin concentration.
http://purl.obolibrary.org/obo/HP_0001924	Sideroblastic anemia	http://purl.obolibrary.org/obo/HP_0010972	Anemia of inadequate production		Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining).
http://purl.obolibrary.org/obo/HP_0001974	Increased total leukocyte count	http://purl.obolibrary.org/obo/HP_0011893	Abnormal leukocyte count		An abnormal increase in the number of leukocytes in the blood.
http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).
http://purl.obolibrary.org/obo/HP_0001997	Gout	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		Recurrent attacks of acute inflammatory arthritis of a joint or set of joints caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues.
http://purl.obolibrary.org/obo/HP_0002015	Dysphagia	http://purl.obolibrary.org/obo/HP_0025270	Abnormal esophagus physiology		Difficulty in swallowing.
http://purl.obolibrary.org/obo/HP_0002035	Rectal prolapse	http://purl.obolibrary.org/obo/HP_0002034	Abnormal rectum morphology		Protrusion of the rectal mucous membrane through the anus.
http://purl.obolibrary.org/obo/HP_0002063	Rigidity	http://purl.obolibrary.org/obo/HP_0001276	Hypertonia		Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity.
http://purl.obolibrary.org/obo/HP_0002066	Gait ataxia	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		A type of ataxia characterized by the impairment of the ability to coordinate the movements required for normal walking. Gait ataxia is characteirzed by a wide-based staggering gait with a tendency to fall.
http://purl.obolibrary.org/obo/HP_0002069	Bilateral tonic-clonic seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A bilateral tonic-clonic seizure is a seizure defined by a tonic (bilateral increased tone, lasting seconds to minutes) and then a clonic (bilateral sustained rhythmic jerking) phase.
http://purl.obolibrary.org/obo/HP_0002090	Pneumonia	http://purl.obolibrary.org/obo/HP_5210123	Unusual lower respiratory tract infection		Inflammation of any part of the lung parenchyma.
http://purl.obolibrary.org/obo/HP_0002094	Dyspnea	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.
http://purl.obolibrary.org/obo/HP_0002098	Respiratory distress	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.
http://purl.obolibrary.org/obo/HP_0002099	Asthma	http://purl.obolibrary.org/obo/HP_0100326	Immunologic hypersensitivity		Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
http://purl.obolibrary.org/obo/HP_0002102	Pleuritis	http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology		Inflammation of the pleura.
http://purl.obolibrary.org/obo/HP_0002105	Hemoptysis	http://purl.obolibrary.org/obo/HP_0032016	Abnormal sputum		Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.
http://purl.obolibrary.org/obo/HP_0002149	Hyperuricemia	http://purl.obolibrary.org/obo/HP_0010932	Abnormal circulating nucleobase concentration		The concentration of uric acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0002156	Homocystinuria	http://purl.obolibrary.org/obo/HP_0033095	Increased sulfur amino acid level in urine		An increased concentration of homocystine in the urine.
http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		The presence of developmental dysplasia of the nail.
http://purl.obolibrary.org/obo/HP_0002202	Pleural effusion	http://purl.obolibrary.org/obo/HP_0000969	Edema		The presence of an excessive amount of fluid in the pleural cavity.
http://purl.obolibrary.org/obo/HP_0002204	Pulmonary embolism	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0002239	Gastrointestinal hemorrhage	http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage		Hemorrhage affecting the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0002248	Hematemesis	http://purl.obolibrary.org/obo/HP_0002239	Gastrointestinal hemorrhage		The vomiting of blood.
http://purl.obolibrary.org/obo/HP_0002249	Melena	http://purl.obolibrary.org/obo/HP_0025085	Bloody diarrhea		The passage of blackish, tarry feces associated with gastrointestinal hemorrhage. Melena occurs if the blood remains in the colon long enough for it to be broken down by colonic bacteria. One degradation product, hematin, imbues the stool with a blackish color. Thus, melena generally occurs with bleeding from the upper gastrointestinal tract (e.g., stomach ulcers or duodenal ulcers), since the blood usually remains in the gut for a longer period of time than with lower gastrointestinal bleeding.
http://purl.obolibrary.org/obo/HP_0002329	Drowsiness	http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness		Abnormal feeling of sleepiness or difficulty staying awake.
http://purl.obolibrary.org/obo/HP_0002354	Memory impairment	http://purl.obolibrary.org/obo/HP_0100543	Cognitive impairment		An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness.
http://purl.obolibrary.org/obo/HP_0002373	Febrile seizure (within the age range of 3 months to 6 years)	http://purl.obolibrary.org/obo/HP_0032894	Seizure precipitated by febrile infection		A febrile seizure is any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in children between the ages of 3 months and 6 years.
http://purl.obolibrary.org/obo/HP_0002573	Hematochezia	http://purl.obolibrary.org/obo/HP_0025085	Bloody diarrhea		The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus.
http://purl.obolibrary.org/obo/HP_0002584	Intestinal bleeding	http://purl.obolibrary.org/obo/HP_0002239	Gastrointestinal hemorrhage		Bleeding from the intestines.
http://purl.obolibrary.org/obo/HP_0002607	Bowel incontinence	http://purl.obolibrary.org/obo/HP_0031064	Impaired continence		Involuntary fecal soiling in adults and children who have usually already been toilet trained.
http://purl.obolibrary.org/obo/HP_0002615	Hypotension	http://purl.obolibrary.org/obo/HP_0030972	Abnormal systemic blood pressure		Low Blood Pressure, vascular hypotension.
http://purl.obolibrary.org/obo/HP_0002633	Vasculitis	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		Inflammation of blood vessel.
http://purl.obolibrary.org/obo/HP_0002650	Scoliosis	http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column		The presence of an abnormal lateral curvature of the spine.
http://purl.obolibrary.org/obo/HP_0002653	Bone pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		Enlargement (swelling) of a lymph node.
http://purl.obolibrary.org/obo/HP_0002721	Immunodeficiency	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.
http://purl.obolibrary.org/obo/HP_0002725	Systemic lupus erythematosus	http://purl.obolibrary.org/obo/HP_0002960	Autoimmunity		A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes.
http://purl.obolibrary.org/obo/HP_0002754	Osteomyelitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism.
http://purl.obolibrary.org/obo/HP_0002789	Tachypnea	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Very rapid breathing.
http://purl.obolibrary.org/obo/HP_0002812	Coxa vara	http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology		Coxa vara includes all forms of decrease of the femoral neck shaft angle (the angle between the neck and the shaft of the femur) to less than 120 degrees.
http://purl.obolibrary.org/obo/HP_0002829	Arthralgia	http://purl.obolibrary.org/obo/HP_0012531	Pain		Joint pain.
http://purl.obolibrary.org/obo/HP_0002840	Lymphadenitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of a lymph node.
http://purl.obolibrary.org/obo/HP_0002912	Methylmalonic acidemia	http://purl.obolibrary.org/obo/HP_0040145	Dicarboxylic acidemia		The concentration of methylmalonic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0002960	Autoimmunity	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		The occurrence of an immune reaction against the organism's own cells or tissues.
http://purl.obolibrary.org/obo/HP_0002970	Genu varum	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		A positional abnormality marked by outward bowing of the legs in which the knees stay wide apart when a person stands with the feet and ankles together.
http://purl.obolibrary.org/obo/HP_0002983	Micromelia	http://purl.obolibrary.org/obo/HP_0009826	Limb undergrowth		The presence of abnormally small extremities.
http://purl.obolibrary.org/obo/HP_0003027	Mesomelia	http://purl.obolibrary.org/obo/HP_0009826	Limb undergrowth		Shortening of the middle parts of the limbs (forearm and lower leg) in relation to the upper and terminal segments.
http://purl.obolibrary.org/obo/HP_0003125	Reduced factor VIII activity	http://purl.obolibrary.org/obo/HP_0030976	Abnormal factor VIII activity		Reduced activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X.
http://purl.obolibrary.org/obo/HP_0003187	Breast hypoplasia	http://purl.obolibrary.org/obo/HP_0010311	Aplasia/Hypoplasia of the breasts		Underdevelopment of the breast.
http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		The presence of skeletal muscular atrophy (which is also known as amyotrophy).
http://purl.obolibrary.org/obo/HP_0003231	Hypertyrosinemia	http://purl.obolibrary.org/obo/HP_0010917	Abnormal circulating tyrosine concentration		An increased concentration of tyrosine in the blood.
http://purl.obolibrary.org/obo/HP_0003307	Hyperlordosis	http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column		Abnormally increased curvature (anterior concavity) of the lumbar or cervical spine.
http://purl.obolibrary.org/obo/HP_0003355	Aminoaciduria	http://purl.obolibrary.org/obo/HP_0025745	Abnormal urine amino acid level		An increased concentration of an amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0003401	Paresthesia	http://purl.obolibrary.org/obo/HP_0033747	Abnormal exteroceptive sensation		Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause.
http://purl.obolibrary.org/obo/HP_0003418	Back pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.
http://purl.obolibrary.org/obo/HP_0003470	Paralysis	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement.
http://purl.obolibrary.org/obo/HP_0003474	Somatic sensory dysfunction	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing.
http://purl.obolibrary.org/obo/HP_0003510	Severe short stature	http://purl.obolibrary.org/obo/HP_0003508	Proportionate short stature		A severe degree of short stature, more than -4 SD from the mean corrected for age and sex.
http://purl.obolibrary.org/obo/HP_0003521	Disproportionate short-trunk short stature	http://purl.obolibrary.org/obo/HP_0009121	Abnormal axial skeleton morphology		A type of disproportionate short stature characterized by a short trunk but a average-sized limbs.
http://purl.obolibrary.org/obo/HP_0003560	Muscular dystrophy	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		The term dystrophy means abnormal growth. However, muscular dystrophy is used to describe primary myopathies with a genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber degeneration (necrosis) and regeneration. If possible, it is preferred to use other HPO terms to describe the precise phenotypic abnormalities.
http://purl.obolibrary.org/obo/HP_0003674	Onset	http://purl.obolibrary.org/obo/HP_0031797	Clinical course		The age group in which disease manifestations appear.
http://purl.obolibrary.org/obo/HP_0003677	Slowly progressive	http://purl.obolibrary.org/obo/HP_0003676	Progressive		Applies to a disease manifestation that only slowly increases in scope or severity over the course of time.
http://purl.obolibrary.org/obo/HP_0003826	Stillbirth	http://purl.obolibrary.org/obo/HP_0034241	Prenatal death		Death of the fetus in utero after at least 22 weeks of gestation.
http://purl.obolibrary.org/obo/HP_0004207	Abnormal 5th finger morphology	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		An abnormality affecting one or both 5th fingers.
http://purl.obolibrary.org/obo/HP_0004313	Decreased circulating immunoglobulin concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		An abnormally decreased level of immunoglobulin in blood.
http://purl.obolibrary.org/obo/HP_0004322	Short stature	http://purl.obolibrary.org/obo/HP_0001510	Growth delay		A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).
http://purl.obolibrary.org/obo/HP_0004430	Severe combined immunodeficiency	http://purl.obolibrary.org/obo/HP_0005387	Combined immunodeficiency		A type of primary immune deficiency that is characterized by a more severe defect in both the T- and B-lymphocyte systems.
http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration	http://purl.obolibrary.org/obo/HP_0005339	Abnormality of complement system		An immunodeficiency defined by the absent or suboptimal functioning of one of the complement system proteins.
http://purl.obolibrary.org/obo/HP_0004566	Pear-shaped vertebrae	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Bulbous appearance of the anterior vertebral bodies, such that the vertebral bodies have the greatest vertical height anteriorly as well as bulbous anterior superior-inferior contours.
http://purl.obolibrary.org/obo/HP_0004789	Lactose intolerance	http://purl.obolibrary.org/obo/HP_0002024	Malabsorption		An inability to digest lactose.
http://purl.obolibrary.org/obo/HP_0005541	Congenital agranulocytosis	http://purl.obolibrary.org/obo/HP_0012234	Absence of circulating granulocytes		Persistent absence of detectable circulating granulocytes in the blood with no detected secondary cause. Usually a value of less than 50 granulocytes per microliter is considered to be an absence.
http://purl.obolibrary.org/obo/HP_0005832	Dysharmonic delayed bone age	http://purl.obolibrary.org/obo/HP_0200000	Dysharmonic skeletal maturation		A type of dysharmonic skeletal maturation in which there is a delay in skeletal maturation whose degree differs markedly in different bones.
http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis.
http://purl.obolibrary.org/obo/HP_0006562	Viral hepatitis	http://purl.obolibrary.org/obo/HP_5210139	Infectious hepatitis		Inflammation of the liver due to infection with a virus.
http://purl.obolibrary.org/obo/HP_0008070	Sparse hair	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		Reduced density of hairs.
http://purl.obolibrary.org/obo/HP_0008734	Decreased testicular size	http://purl.obolibrary.org/obo/HP_0010468	Aplasia/Hypoplasia of the testes		Reduced volume of the testicle (the male gonad).
http://purl.obolibrary.org/obo/HP_0008873	Disproportionate short-limb short stature	http://purl.obolibrary.org/obo/HP_0003498	Disproportionate short stature		A type of disproportionate short stature characterized by a short limbs but an average-sized trunk.
http://purl.obolibrary.org/obo/HP_0009125	Lipodystrophy	http://purl.obolibrary.org/obo/HP_0009124	Abnormal adipose tissue morphology		Degenerative changes of the fat tissue.
http://purl.obolibrary.org/obo/HP_0009473	Joint contracture of the hand	http://purl.obolibrary.org/obo/HP_0100360	Upper-limb joint contracture		Contractures of one ore more joints of the hands meaning chronic loss of joint motion due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009763	Limb pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		Chronic pain in the limbs with no clear focal etiology.
http://purl.obolibrary.org/obo/HP_0009797	Cholesteatoma	http://purl.obolibrary.org/obo/HP_0100799	Neoplasm of the middle ear		Cholesteatoma is a benign but potentially destructive growth consisting of keratinizing epithelium located in the middle ear and/or mastoid process. In cholesteatoma, a skin cyst grows into the middle ear and mastoid. The cyst is not cancerous but can erode tissue and cause destruction of the ear.
http://purl.obolibrary.org/obo/HP_0010884	Acromelia	http://purl.obolibrary.org/obo/HP_0009815	Aplasia/hypoplasia of the extremities		Shortening of the extremities affecting primarily the distal parts of the limbs (hands and feet) in relation to the other segments of the limbs.
http://purl.obolibrary.org/obo/HP_0010885	Avascular necrosis	http://purl.obolibrary.org/obo/HP_0011843	Abnormal musculoskeletal physiology		A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density	http://purl.obolibrary.org/obo/HP_0004348	Abnormality of bone mineral density		An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often referred to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones.
http://purl.obolibrary.org/obo/HP_0011002	Osteopetrosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Abnormally increased formation of dense trabecular bone tissue. Despite the increased density of bone tissue, osteopetrotic bones tend to be more fracture-prone than normal.
http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage	http://purl.obolibrary.org/obo/HP_0011028	Abnormality of blood circulation		The presence of hemorrhage within the body.
http://purl.obolibrary.org/obo/HP_0011110	Recurrent tonsillitis	http://purl.obolibrary.org/obo/HP_0100765	Abnormality of the tonsils		Inflammation of the tonsils that has occurred repeatedly. The definition of recurrent may vary somewhat, but the criteria used recently as a measure of severity were five or more episodes of true tonsillitis per year, symptoms recurring for at least a year, and episodes that are disabling and that prevent normal functioning. In some cases recurrent tonsillitis may be related to immunosusceptibility. Evidence exists for a genetic predisposition for recurrent tonsillitis.
http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes.
http://purl.obolibrary.org/obo/HP_0011147	Typical absence seizure	http://purl.obolibrary.org/obo/HP_0002121	Generalized non-motor (absence) seizure		A typical absence seizure is a type of generalized non-motor (absence) seizure characterized by its sudden onset, interruption of ongoing activities, a blank stare, possibly a brief upward deviation of the eyes. Usually the patient will be unresponsive when spoken to. Duration is a few seconds to half a minute with very rapid recovery. Although not always available, an EEG would usually show 3 Hz generalized epileptiform discharges during the event.
http://purl.obolibrary.org/obo/HP_0011220	Prominent forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		Forward prominence of the entire forehead, due to protrusion of the frontal bone.
http://purl.obolibrary.org/obo/HP_0100021	Cerebral palsy	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Cerebral palsy describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to nonprogressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behavior, by epilepsy, and by secondary musculoskeletal problems.
http://purl.obolibrary.org/obo/HP_0100034	Motor tics	http://purl.obolibrary.org/obo/HP_0100033	Tics		Movement-based tics affecting discrete muscle groups.
http://purl.obolibrary.org/obo/HP_0100035	Phonic tics	http://purl.obolibrary.org/obo/HP_4000074	Involuntary vocalization		Tics are defined as movements or sounds that resemble physiological motor behaviors, but are typically inopportune to social context and appear sudden, repetitive, and often exaggerated. Tic vocalizations commonly termed vocal or phonic tics may include any possible sound (eg, sniffing, coughing, throat clearing, whistling, or grunting), word, or sentence and are most commonly encountered within the spectrum of primary tic disorders, as Tourette syndrome.
http://purl.obolibrary.org/obo/HP_0100255	Metaphyseal dysplasia	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		The presence of dysplastic regions in metaphyseal regions.
http://purl.obolibrary.org/obo/HP_0100502	Decreased circulating vitamin B12 concentration	http://purl.obolibrary.org/obo/HP_0004341	Abnormal vitamin B12 concentration		The concentration of vitamin B12 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100512	Decreased circulating vitamin D concentration	http://purl.obolibrary.org/obo/HP_0100511	Abnormal circulating vitamin D concentration		The concentration of vitamin D in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100598	Pulmonary edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Fluid accumulation in the lungs.
http://purl.obolibrary.org/obo/HP_0100614	Myositis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		A general term for inflammation of the muscles without respect to the underlying cause.
http://purl.obolibrary.org/obo/HP_0100699	Scarring	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		A scar refers to a lesion in which wound, burn, or sore has not healed completely and fibrous connective tissue has developed.
http://purl.obolibrary.org/obo/HP_0100774	Hyperostosis	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Excessive growth or abnormal thickening of bone tissue.
http://purl.obolibrary.org/obo/HP_0100785	Insomnia	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		Persistent difficulty in starting or maintaining sleep, or waking up earlier than desired, despite having adequate opportunities and conditions for sleep.
http://purl.obolibrary.org/obo/HP_0100806	Sepsis	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.
http://purl.obolibrary.org/obo/HP_0100845	Anaphylactic shock	http://purl.obolibrary.org/obo/HP_0100326	Immunologic hypersensitivity		An acute hypersensitivity reaction due to exposure to a previously encountered antigen.
http://purl.obolibrary.org/obo/HP_0100963	Hyperesthesia	http://purl.obolibrary.org/obo/HP_0033747	Abnormal exteroceptive sensation		Increased sensitivity to stimulation, excluding the special senses, which may refer to various modes of cutaneous sensibility including touch and thermal sensation without pain, as well as to pain.
http://purl.obolibrary.org/obo/UBERON_0000007	pituitary gland	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN].
http://purl.obolibrary.org/obo/UBERON_0000010	peripheral nervous system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.
http://purl.obolibrary.org/obo/UBERON_0000016	endocrine pancreas	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin.
http://purl.obolibrary.org/obo/UBERON_0000020	sense organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		An organ that is capable of transducing sensory stimulus to the nervous system.
http://purl.obolibrary.org/obo/UBERON_0000029	lymph node	http://purl.obolibrary.org/obo/UBERON_0005057	immune organ		Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph.
http://purl.obolibrary.org/obo/UBERON_0000056	ureter	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs.
http://purl.obolibrary.org/obo/UBERON_0000059	large intestine	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong].
http://purl.obolibrary.org/obo/UBERON_0000065	respiratory tract	http://purl.obolibrary.org/obo/UBERON_0001005	respiratory airway		Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts.
http://purl.obolibrary.org/obo/UBERON_0000159	anal canal	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus.
http://purl.obolibrary.org/obo/UBERON_0000160	intestine	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.
http://purl.obolibrary.org/obo/UBERON_0000165	mouth	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).
http://purl.obolibrary.org/obo/UBERON_0000167	oral cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present).
http://purl.obolibrary.org/obo/UBERON_0000178	blood	http://purl.obolibrary.org/obo/UBERON_0000179	haemolymphatic fluid		A fluid that is composed of blood plasma and erythrocytes.
http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.
http://purl.obolibrary.org/obo/UBERON_0000945	stomach	http://purl.obolibrary.org/obo/UBERON_0010039	food storage organ		An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.
http://purl.obolibrary.org/obo/UBERON_0000948	heart	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.
http://purl.obolibrary.org/obo/UBERON_0000949	endocrine system	http://purl.obolibrary.org/obo/UBERON_0015204	glandular system		Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.
http://purl.obolibrary.org/obo/UBERON_0000955	brain	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
http://purl.obolibrary.org/obo/UBERON_0000964	cornea	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.
http://purl.obolibrary.org/obo/UBERON_0000965	lens of camera-type eye	http://purl.obolibrary.org/obo/UBERON_0005389	transparent eye structure		A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina.
http://purl.obolibrary.org/obo/UBERON_0000966	retina	http://purl.obolibrary.org/obo/UBERON_0005388	photoreceptor array		The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
http://purl.obolibrary.org/obo/UBERON_0000970	eye	http://purl.obolibrary.org/obo/UBERON_0000020	sense organ		An organ that detects light.
http://purl.obolibrary.org/obo/UBERON_0000977	pleura	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).
http://purl.obolibrary.org/obo/UBERON_0000989	penis	http://purl.obolibrary.org/obo/UBERON_0008811	intromittent organ		An intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination.
http://purl.obolibrary.org/obo/UBERON_0000990	reproductive system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Anatomical system that has as its parts the organs concerned with reproduction.
http://purl.obolibrary.org/obo/UBERON_0000992	ovary	http://purl.obolibrary.org/obo/UBERON_0003134	female reproductive organ		The gonad of a female organism which contains germ cells.
http://purl.obolibrary.org/obo/UBERON_0000995	uterus	http://purl.obolibrary.org/obo/UBERON_0013515	subdivision of oviduct		The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth.
http://purl.obolibrary.org/obo/UBERON_0000996	vagina	http://purl.obolibrary.org/obo/UBERON_0013515	subdivision of oviduct		A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP].
http://purl.obolibrary.org/obo/UBERON_0000997	mammalian vulva	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		External genital organs of the female mammal[WP].
http://purl.obolibrary.org/obo/UBERON_0000998	seminal vesicle	http://purl.obolibrary.org/obo/UBERON_0006868	seminal fluid secreting gland		Either of a pair of glandular pouches that lie one on either side of the male reproductive tract posterolateral to the urinary bladder and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct.
http://purl.obolibrary.org/obo/UBERON_0001004	respiratory system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Functional system which consists of structures involved in respiration.
http://purl.obolibrary.org/obo/UBERON_0001016	nervous system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].
http://purl.obolibrary.org/obo/UBERON_0001017	central nervous system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
http://purl.obolibrary.org/obo/UBERON_0001032	sensory system	http://purl.obolibrary.org/obo/UBERON_0015203	non-connected functional system		Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information.
http://purl.obolibrary.org/obo/UBERON_0001043	esophagus	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).
http://purl.obolibrary.org/obo/UBERON_0001044	saliva-secreting gland	http://purl.obolibrary.org/obo/UBERON_0010047	oral gland		Saliva-secreting exocrine glands of the oral cavity[GO].
http://purl.obolibrary.org/obo/UBERON_0001052	rectum	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The terminal portion of the intestinal tube, terminating with the anus.
http://purl.obolibrary.org/obo/UBERON_0001091	calcareous tooth	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food.
http://purl.obolibrary.org/obo/UBERON_0001103	diaphragm	http://purl.obolibrary.org/obo/UBERON_0003831	respiratory system muscle		A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control.
http://purl.obolibrary.org/obo/UBERON_0001130	vertebral column	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO].
http://purl.obolibrary.org/obo/UBERON_0001132	parathyroid gland	http://purl.obolibrary.org/obo/UBERON_0002368	endocrine gland		The parathyroid gland is an endocrine gland for secretion of parathyroid hormone, usually found as a pair, embedded in the connective tissue capsule on the posterior surface of the thyroid gland. Parathyroid regulates calcium and phosphorous metabolism.
http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue	http://purl.obolibrary.org/obo/UBERON_0002036	striated muscle tissue		Muscle tissue that consists primarily of skeletal muscle fibers.
http://purl.obolibrary.org/obo/UBERON_0001155	colon	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal.
http://purl.obolibrary.org/obo/UBERON_0001158	descending colon	http://purl.obolibrary.org/obo/UBERON_0000168	proximal-distal subdivision of colon		The portion of the colon between the left colic flexure and the sigmoid colon at the pelvic brim; the portion of the descending colon lying in the left iliac fossa is sometimes called the iliac colon.
http://purl.obolibrary.org/obo/UBERON_0001159	sigmoid colon	http://purl.obolibrary.org/obo/UBERON_0000168	proximal-distal subdivision of colon		The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity.
http://purl.obolibrary.org/obo/UBERON_0001165	pyloric antrum	http://purl.obolibrary.org/obo/UBERON_0009870	zone of stomach		The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells.
http://purl.obolibrary.org/obo/UBERON_0001166	pylorus	http://purl.obolibrary.org/obo/UBERON_0009870	zone of stomach		The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum.
http://purl.obolibrary.org/obo/UBERON_0001184	renal artery	http://purl.obolibrary.org/obo/UBERON_0012254	abdominal aorta artery		One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates.
http://purl.obolibrary.org/obo/UBERON_0001245	anus	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts.
http://purl.obolibrary.org/obo/UBERON_0001255	urinary bladder	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].
http://purl.obolibrary.org/obo/UBERON_0001258	neck of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0001560	neck of organ		The constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra[MP].
http://purl.obolibrary.org/obo/UBERON_0001295	endometrium	http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa		The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy.
http://purl.obolibrary.org/obo/UBERON_0001299	glans penis	http://purl.obolibrary.org/obo/UBERON_0035651	glans		The conic expansion of the corpus spongiosum that forms the head of the penis.
http://purl.obolibrary.org/obo/UBERON_0001300	scrotum	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		The external sac of skin that encloses the testes. It is an extension of the abdomen, and in placentals is located between the penis and anus.
http://purl.obolibrary.org/obo/UBERON_0001301	epididymis	http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system		The elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens.
http://purl.obolibrary.org/obo/UBERON_0001322	sciatic nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A large nerve that supplies nearly the whole of the skin of the leg, the muscles of the back of the thigh, and those of the leg and foot. It begins in the lower back and runs through the buttock and down the lower limb.
http://purl.obolibrary.org/obo/UBERON_0001323	tibial nerve	http://purl.obolibrary.org/obo/UBERON_0003431	leg nerve		The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001361	femoral vein	http://purl.obolibrary.org/obo/UBERON_0003516	hindlimb blood vessel		In the human body, the femoral vein is a blood vessel that accompanies the femoral artery in the femoral sheath. It begins at the adductor canal (also known as Hunter's canal) and is a continuation of the popliteal vein. It ends at the inferior margin of the inguinal ligament, where it becomes the external iliac vein. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001535	vertebral artery	http://purl.obolibrary.org/obo/UBERON_0002458	spinal artery		The first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck.
http://purl.obolibrary.org/obo/UBERON_0001558	lower respiratory tract	http://purl.obolibrary.org/obo/UBERON_0000072	proximo-distal subdivision of respiratory tract		The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001637	artery	http://purl.obolibrary.org/obo/UBERON_0003509	arterial blood vessel		An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].
http://purl.obolibrary.org/obo/UBERON_0001644	trochlear nerve	http://purl.obolibrary.org/obo/UBERON_0001785	cranial nerve		A cranial nerve that runs to the eye muscles.
http://purl.obolibrary.org/obo/UBERON_0001646	abducens nerve	http://purl.obolibrary.org/obo/UBERON_0001785	cranial nerve		Cranial nerve that runs to the eye muscles.
http://purl.obolibrary.org/obo/UBERON_0001648	vestibulocochlear nerve	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain.
http://purl.obolibrary.org/obo/UBERON_0001650	hypoglossal nerve	http://purl.obolibrary.org/obo/UBERON_0001785	cranial nerve		Cranial nerve that innervates the muscles of the tongue.
http://purl.obolibrary.org/obo/UBERON_0001677	sphenoid bone	http://purl.obolibrary.org/obo/UBERON_0015060	sphenoid endochondral element		An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended.
http://purl.obolibrary.org/obo/UBERON_0001705	nail	http://purl.obolibrary.org/obo/UBERON_0009564	distal limb integumentary appendage		A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP].
http://purl.obolibrary.org/obo/UBERON_0001707	nasal cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		An anatomical cavity that is part of the olfactory apparatus. This includes the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present.
http://purl.obolibrary.org/obo/UBERON_0001708	jaw skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Subdivision of skeleton which includes upper and lower jaw skeletons.
http://purl.obolibrary.org/obo/UBERON_0001711	eyelid	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A fold of skin that covers and protects part of the eyeball. Examples: upper eyelid, lower eyelid, nictitating membrane.
http://purl.obolibrary.org/obo/UBERON_0001723	tongue	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A muscular organ in the floor of the mouth.
http://purl.obolibrary.org/obo/UBERON_0001724	sphenoidal sinus	http://purl.obolibrary.org/obo/UBERON_0001825	paranasal sinus		One of the paired paranasal sinuses, located in the body of the sphenoid bone and communicating with the highest meatus of the nasal cavity on the same side[MESH]. The sphenoidal sinuses (or sphenoid) contained within the body of the sphenoid vary in size and shape; owing to the lateral displacement of the intervening septum they are rarely symmetrical. The following are their average measurements: vertical height, 2.2 cm. ; transverse breadth, 2 cm. ; antero-posterior depth, 2.2 cm. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001736	submandibular gland	http://purl.obolibrary.org/obo/UBERON_0001829	major salivary gland		Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible.
http://purl.obolibrary.org/obo/UBERON_0001737	larynx	http://purl.obolibrary.org/obo/UBERON_0000072	proximo-distal subdivision of respiratory tract		A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.
http://purl.obolibrary.org/obo/UBERON_0001739	laryngeal cartilage	http://purl.obolibrary.org/obo/UBERON_0011004	pharyngeal arch cartilage		The cartilaginous structures that support the larynx.
http://purl.obolibrary.org/obo/UBERON_0001750	lacrimal apparatus	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		A network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta.
http://purl.obolibrary.org/obo/UBERON_0001756	middle ear	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)[GO].
http://purl.obolibrary.org/obo/UBERON_0001759	vagus nerve	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart).
http://purl.obolibrary.org/obo/UBERON_0001760	frontal sinus	http://purl.obolibrary.org/obo/UBERON_0001825	paranasal sinus		The frontal sinus occupies the dorsal part of the skull medial to the orbit. It overlaps cranial and nasal cavities and is often referred to as the conchofrontal sinus.
http://purl.obolibrary.org/obo/UBERON_0001764	maxillary sinus	http://purl.obolibrary.org/obo/UBERON_0001825	paranasal sinus		One of the paired paranasal sinuses, located in the body of the maxilla, communicating with the middle meatus of the nasal cavity.
http://purl.obolibrary.org/obo/UBERON_0001776	optic choroid	http://purl.obolibrary.org/obo/UBERON_0002203	vasculature of eye		Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].
http://purl.obolibrary.org/obo/UBERON_0001811	conjunctiva	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball.
http://purl.obolibrary.org/obo/UBERON_0001820	sweat gland	http://purl.obolibrary.org/obo/UBERON_0019319	exocrine gland of integumental system		Any of the coil glands of the skin that secrete sweat.
http://purl.obolibrary.org/obo/UBERON_0001825	paranasal sinus	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity.
http://purl.obolibrary.org/obo/UBERON_0001831	parotid gland	http://purl.obolibrary.org/obo/UBERON_0012102	buccal salivary gland		The parotid gland is the largest of the salivary glands. It is found wrapped around the mandibular ramus, and it secretes saliva through Stensen's duct into the oral cavity, to facilitate mastication and swallowing. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001833	lip	http://purl.obolibrary.org/obo/UBERON_0003102	surface structure		One of the two fleshy folds which surround the opening of the mouth.
http://purl.obolibrary.org/obo/UBERON_0001872	parietal lobe	http://purl.obolibrary.org/obo/UBERON_0016526	lobe of cerebral hemisphere		Upper central part of the cerebral hemisphere. (MSH).
http://purl.obolibrary.org/obo/UBERON_0001961	mucosa-associated lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0012069	epithelium-associated lymphoid tissue		Diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO].
http://purl.obolibrary.org/obo/UBERON_0001982	capillary	http://purl.obolibrary.org/obo/UBERON_8410081	blood microvessel		Any of the smallest blood vessels connecting arterioles with venules.
http://purl.obolibrary.org/obo/UBERON_0002012	pulmonary artery	http://purl.obolibrary.org/obo/UBERON_0013768	great vessel of heart		An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood..
http://purl.obolibrary.org/obo/UBERON_0002046	thyroid gland	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO].
http://purl.obolibrary.org/obo/UBERON_0002048	lung	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Respiration organ that develops as an outpocketing of the esophagus.
http://purl.obolibrary.org/obo/UBERON_0002068	urachus	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		A fibrous remnant of the allantoic stalk, a narrow fetal canal connecting the apex of the urinary bladder with the umbilicus located in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly. its lumen is normally obliterated during development, transforming the urachus into a solid cord, a functionless remnant that persists throughout life as the median umbilical ligament; failure of complete lumen obliteration may result in distinct congenital urachal remnant anomalies[MP].
http://purl.obolibrary.org/obo/UBERON_0002101	limb	http://purl.obolibrary.org/obo/UBERON_0004708	paired limb/fin		A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts.
http://purl.obolibrary.org/obo/UBERON_0002106	spleen	http://purl.obolibrary.org/obo/UBERON_0017672	abdominal viscera		The organ that functions to filter blood and to store red corpuscles and platelets.
http://purl.obolibrary.org/obo/UBERON_0002107	liver	http://purl.obolibrary.org/obo/UBERON_0006925	digestive system gland		An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].
http://purl.obolibrary.org/obo/UBERON_0002108	small intestine	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong].
http://purl.obolibrary.org/obo/UBERON_0002110	gallbladder	http://purl.obolibrary.org/obo/UBERON_0017672	abdominal viscera		An organ that aids digestion and stores bile produced by the liver[WP].
http://purl.obolibrary.org/obo/UBERON_0002113	kidney	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A paired organ of the urinary tract that produces urine and maintains bodily fluid homeostasis, blood pressure, pH levels, red blood cell production and skeleton mineralization.
http://purl.obolibrary.org/obo/UBERON_0002114	duodenum	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).
http://purl.obolibrary.org/obo/UBERON_0002115	jejunum	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The portion of the small intestine that extends from the duodenum to the ileum.
http://purl.obolibrary.org/obo/UBERON_0002116	ileum	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The portion of the small intestine that extends from the jejunum to the colon.
http://purl.obolibrary.org/obo/UBERON_0002134	tricuspid valve	http://purl.obolibrary.org/obo/UBERON_0005208	right atrium valve		An atrioventricular valve that is part of the outflow part of the right atrium.
http://purl.obolibrary.org/obo/UBERON_0002165	endocardium	http://purl.obolibrary.org/obo/UBERON_0005983	heart layer		The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO].
http://purl.obolibrary.org/obo/UBERON_0002185	bronchus	http://purl.obolibrary.org/obo/UBERON_0000117	respiratory tube		The upper conducting airways of the lung; these airways arise from the terminus of the trachea.
http://purl.obolibrary.org/obo/UBERON_0002204	musculoskeletal system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Anatomical system that consists of the muscular and skeletal systems.
http://purl.obolibrary.org/obo/UBERON_0002240	spinal cord	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).
http://purl.obolibrary.org/obo/UBERON_0002279	vestibular aqueduct	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		At the hinder part of the medial wall of the vestibule is the orifice of the vestibular aqueduct, which extends to the posterior surface of the petrous portion of the temporal bone. It transmits a small vein, and contains a tubular prolongation of the membranous labyrinth, the ductus endolymphaticus, which ends in a cul-de-sac between the layers of the dura mater within the cranial cavity. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002293	costochondral joint	http://purl.obolibrary.org/obo/UBERON_0002215	synchondrosis		A bars of hyaline cartilage located between the distal part of a rib and a costal cartilage, connecting the ribs to the sternum .
http://purl.obolibrary.org/obo/UBERON_0002298	brainstem	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].
http://purl.obolibrary.org/obo/UBERON_0002330	exocrine system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia].
http://purl.obolibrary.org/obo/UBERON_0002336	corpus callosum	http://purl.obolibrary.org/obo/UBERON_0005340	dorsal telencephalic commissure		White matter structure containing massive numbers of commissural fibers connecting cortical areas in the two cerebral hemispheres. It is subdivided into a genu, a rostrum, a body, and a splenium. (MM).
http://purl.obolibrary.org/obo/UBERON_0002351	sinoatrial node	http://purl.obolibrary.org/obo/UBERON_0010131	conducting tissue of heart		The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA].
http://purl.obolibrary.org/obo/UBERON_0002358	peritoneum	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		A serous membrane that lines the peritoneal cavity[VHOG,modified].
http://purl.obolibrary.org/obo/UBERON_0002367	prostate gland	http://purl.obolibrary.org/obo/UBERON_0010147	male accessory sex gland		The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
http://purl.obolibrary.org/obo/UBERON_0002368	endocrine gland	http://purl.obolibrary.org/obo/UBERON_0002530	gland		Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].
http://purl.obolibrary.org/obo/UBERON_0002370	thymus	http://purl.obolibrary.org/obo/UBERON_0005058	hemolymphoid system gland		Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop.
http://purl.obolibrary.org/obo/UBERON_0002372	tonsil	http://purl.obolibrary.org/obo/UBERON_0001962	gut-associated lymphoid tissue		Either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx.
http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.
http://purl.obolibrary.org/obo/UBERON_0002387	pes	http://purl.obolibrary.org/obo/UBERON_0008784	lower limb segment		Distal portion of the hind limb, including tarsal region, metatarsal region and digits.
http://purl.obolibrary.org/obo/UBERON_0002389	manual digit	http://purl.obolibrary.org/obo/UBERON_0002544	digit		A digit that is part of a manus (hand).
http://purl.obolibrary.org/obo/UBERON_0002391	lymph	http://purl.obolibrary.org/obo/UBERON_0000179	haemolymphatic fluid		Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP].
http://purl.obolibrary.org/obo/UBERON_0002394	bile duct	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine.
http://purl.obolibrary.org/obo/UBERON_0002398	manus	http://purl.obolibrary.org/obo/UBERON_0008785	upper limb segment		Distal segment of the fore limb, including carpal region, metacarpal region and digits.
http://purl.obolibrary.org/obo/UBERON_0002405	immune system	http://purl.obolibrary.org/obo/UBERON_0015203	non-connected functional system		Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.
http://purl.obolibrary.org/obo/UBERON_0002407	pericardium	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium.
http://purl.obolibrary.org/obo/UBERON_0002410	autonomic nervous system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO].
http://purl.obolibrary.org/obo/UBERON_0002416	integumental system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.
http://purl.obolibrary.org/obo/UBERON_0002446	patella	http://purl.obolibrary.org/obo/UBERON_0011141	appendicular ossicle		A large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods. The patella is the attachment site for proximal hindlimb tendons.[PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0002453	ethmoid sinus	http://purl.obolibrary.org/obo/UBERON_0001825	paranasal sinus		The evaginations of the mucous membrane of the nasal cavity into the ethmoidal bony labyrinth, forming multiple small paranasal sinuses.
http://purl.obolibrary.org/obo/UBERON_0003126	trachea	http://purl.obolibrary.org/obo/UBERON_0000117	respiratory tube		The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph].
http://purl.obolibrary.org/obo/UBERON_0003133	reproductive organ	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An organ involved in reproduction.
http://purl.obolibrary.org/obo/UBERON_0003134	female reproductive organ	http://purl.obolibrary.org/obo/UBERON_0003133	reproductive organ		A female organ involved in reproduction.
http://purl.obolibrary.org/obo/UBERON_0003135	male reproductive organ	http://purl.obolibrary.org/obo/UBERON_0003133	reproductive organ		A male organ involved in reproduction.
http://purl.obolibrary.org/obo/UBERON_0003221	phalanx	http://purl.obolibrary.org/obo/UBERON_0015023	phalanx endochondral element		Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits.
http://purl.obolibrary.org/obo/UBERON_0003690	fused sacrum	http://purl.obolibrary.org/obo/UBERON_0008001	irregular bone		A collection of sacral vertebrae in the sacral region that are fused and part of the bony pelvis.
http://purl.obolibrary.org/obo/UBERON_0003691	epidural space	http://purl.obolibrary.org/obo/UBERON_0010276	space in vertebral column		The outermost part of the spinal canal. It is the space within the canal (formed by the surrounding vertebrae) lying outside the dura mater.
http://purl.obolibrary.org/obo/UBERON_0003693	retroperitoneal space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		Anatomical space in the abdominal cavity behind (retro) the peritoneum. It has no specific delineating anatomical structures. Organs are retroperitoneal if they only have peritoneum on their anterior side.
http://purl.obolibrary.org/obo/UBERON_0003703	extrahepatic bile duct	http://purl.obolibrary.org/obo/UBERON_0002394	bile duct		Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct.
http://purl.obolibrary.org/obo/UBERON_0003728	mediastinum	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The central part of the thoracic cavity enclosed by the left and right pleurae.
http://purl.obolibrary.org/obo/UBERON_0003889	fallopian tube	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Initial section of the oviduct through which the ova pass from the ovary to the uterus.
http://purl.obolibrary.org/obo/UBERON_0003959	rete testis	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An anastomosing network of delicate tubules located in the hilum of the testicle (mediastinum testis) that carries sperm from the seminiferous tubules to the vasa efferentia[WP].
http://purl.obolibrary.org/obo/UBERON_0004014	labium minora	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		One of the folds of skin which form the inner lips on both sides of the vaginal opening.
http://purl.obolibrary.org/obo/UBERON_0004085	labium majora	http://purl.obolibrary.org/obo/UBERON_0004084	genital labium		One of the folds of skin which form the outer lips on both sides of the vaginal opening.
http://purl.obolibrary.org/obo/UBERON_0004117	pharyngeal pouch	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches.
http://purl.obolibrary.org/obo/UBERON_0004535	cardiovascular system	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		Anatomical system that has as its parts the heart and blood vessels.
http://purl.obolibrary.org/obo/UBERON_0004913	hepatopancreatic ampulla	http://purl.obolibrary.org/obo/UBERON_0002394	bile duct		A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct.
http://purl.obolibrary.org/obo/UBERON_0005057	immune organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		An organ that is part of a immune system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005352	spermatic cord	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		The cord-like structure in males comprising the vas deferens and associated tissue that runs from the abdomen down to each testis[MP].
http://purl.obolibrary.org/obo/UBERON_0005409	alimentary part of gastrointestinal system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		The part of the digestive system that excludes the hepatobiliary system.
http://purl.obolibrary.org/obo/UBERON_0005610	iliac vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		Any of the three veins including the common, external and internal iliac veins.
http://purl.obolibrary.org/obo/UBERON_0006558	lymphatic part of lymphoid system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		An organ system subdivision that is a network of vessels capable of removing accumulating protein and fluid from the interstitial space and returning it to the vascular space. In some species, this network is connected to the immune system via lymph nodes and lymphocyte-producing organs, with the whole being the lymphoid system.
http://purl.obolibrary.org/obo/UBERON_0006562	pharynx	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The pharynx is the part of the digestive system immediately posterior to the mouth[GO].
http://purl.obolibrary.org/obo/UBERON_0006589	round ligament of uterus	http://purl.obolibrary.org/obo/UBERON_0008845	nonskeletal ligament		The round ligament of the uterus originates at the uterine horns, in the parametrium. It leaves the pelvis via the deep inguinal ring, passes through the inguinal canal and continues on to the labia majora where its fibers spread and mix with the tissue of the mons pubis[WP]. A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus[MESH].
http://purl.obolibrary.org/obo/UBERON_0006810	olecranon	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		The olecranon is a large, thick, curved bony eminence of the forearm that projects behind the elbow. It is situated at the upper (proximal) end of the ulna, one of the two bones in the forearm. When the hand faces forward the olecranon faces towards the back (posteriorly). It is bent forward at the summit so as to present a prominent lip which is received into the olecranon fossa of the humerus in extension of the forearm. Its base is contracted where it joins the body and the narrowest part of the upper end of the ulna. Its posterior surface, directed backward, is triangular, smooth, subcutaneous, and covered by a bursa. Its superior surface is of quadrilateral form, marked behind by a rough impression for the insertion of the Triceps brachii; and in front, near the margin, by a slight transverse groove for the attachment of part of the posterior ligament of the elbow-joint. Its anterior surface is smooth, concave, and forms the upper part of the semilunar notch. Its borders present continuations of the groove on the margin of the superior surface; they serve for the attachment of ligaments, viz. , the back part of the ulnar collateral ligament medially, and the posterior ligament laterally. From the medial border a part of the Flexor carpi ulnaris arises; while to the lateral border the anconeus muscle is attached.
http://purl.obolibrary.org/obo/UBERON_0008230	tibialis	http://purl.obolibrary.org/obo/UBERON_0004256	hindlimb zeugopod muscle		Either of two muscles of the calf of the leg.
http://purl.obolibrary.org/obo/UBERON_0010011	collection of basal ganglia	http://purl.obolibrary.org/obo/UBERON_0010009	aggregate regional part of brain		Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum.
http://purl.obolibrary.org/obo/UBERON_0011374	prepuce	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		A retractable double-layered fold of skin and mucous membrane that covers the glans penis or clitoris. Glands may also be present.
http://purl.obolibrary.org/obo/UBERON_0011818	superficial fascia	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Superficial fascia is found in the subcutis in most regions of the body, blending with the reticular layer of the dermis. It is present on the face, over the upper portion of the sternocleidomastoid, at the nape of the neck, and overlying the sternum. It is comprised mainly of loose areolar connective tissue and adipose and is the layer that primarily determines the shape of a body. In addition to its subcutaneous presence, this type of fascia surrounds organs and glands, neurovascular bundles, and is found at many other locations where it fills otherwise unoccupied space. It serves as a storage medium of fat and water; as a passageway for lymph, nerve and blood vessels; and as a protective padding to cushion and insulate. Superficial fascia is present, but does not contain fat, in the eyelids, ear, scrotum, penis and clitoris.
http://purl.obolibrary.org/obo/UBERON_0012332	broad ligament of uterus	http://purl.obolibrary.org/obo/UBERON_0000211	ligament		A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis.
http://purl.obolibrary.org/obo/UBERON_0016410	male breast	http://purl.obolibrary.org/obo/UBERON_0000310	breast		A breast that is part of a male organism.
http://purl.obolibrary.org/obo/UBERON_0016435	chest wall	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		Subdivision of thorax which includes all structures from the skin to the costal pleura. Examples: There is only one chest wall.
http://purl.obolibrary.org/obo/UBERON_0016525	frontal lobe	http://purl.obolibrary.org/obo/UBERON_0016526	lobe of cerebral hemisphere		Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border.
http://purl.obolibrary.org/obo/UBERON_0034940	venous sinus cavity	http://purl.obolibrary.org/obo/UBERON_0010161	lumen of blood vessel		An enlarged chamber in the blood sinus capable of accumulating a large volume of blood.
http://purl.obolibrary.org/obo/UBERON_0034953	embryonic lymph sac	http://purl.obolibrary.org/obo/UBERON_0007499	epithelial sac		A population of lymphatic endothelial cell precursors that will form the lymph vessels.
http://purl.obolibrary.org/obo/UBERON_0035032	abdominal oblique muscle	http://purl.obolibrary.org/obo/UBERON_0002461	anterior abdominal wall muscle		Either the external or internal abdominal oblique muscles.
http://purl.obolibrary.org/obo/UBERON_0035045	parotid gland intralobular duct	http://purl.obolibrary.org/obo/UBERON_0014719	intralobular duct		Any of the tubular canals of the parotid gland located within the parenchymal (secretory) tissue i.e. within lobules; both intercalated and striated (secretory) ducts are intralobular ducts.
http://purl.obolibrary.org/obo/UBERON_0035048	parotid gland excretory duct	http://purl.obolibrary.org/obo/UBERON_0035049	excretory duct of salivary gland		Any of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product.
http://purl.obolibrary.org/obo/UBERON_0035078	parotid gland interlobular duct	http://purl.obolibrary.org/obo/UBERON_0035053	interlobular duct of salivary gland		Any of the excretory ducts of the parotid gland which are found in the connective tissue septa i.e. between lobules.
http://purl.obolibrary.org/obo/UBERON_0035083	transverse process-bearing vertebra	http://purl.obolibrary.org/obo/UBERON_0002412	vertebra		A vertebra that has a transverse process.
http://purl.obolibrary.org/obo/UBERON_0035102	transverse process of caudal vertebra	http://purl.obolibrary.org/obo/UBERON_0001077	transverse process of vertebra		A transverse process that is part of a caudal vertebra.
http://purl.obolibrary.org/obo/UBERON_0035106	raphe of perineum	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		The perineal raphe extends from the anus, through the mid-line of the scrotum (scrotal raphe) and upwards through the posterior mid-line aspect of the penis (penile raphe).
http://purl.obolibrary.org/obo/UBERON_0035112	intrinsic muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Any of the muscles that are entirely within the body part or segment moved by them.
http://purl.obolibrary.org/obo/UBERON_0035115	diastema between central incisors	http://purl.obolibrary.org/obo/UBERON_0035119	diastema between incisors		A space or gap between the left and right central incisors, on either the upper or lower jaw.
http://purl.obolibrary.org/obo/UBERON_0035117	diastema between lower central incisors	http://purl.obolibrary.org/obo/UBERON_0035115	diastema between central incisors		A space or gap between the left and right central incisors on the lower jaw.
http://purl.obolibrary.org/obo/UBERON_0035127	suture of hard palate	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		Any of the sutures of the hard palate.
http://purl.obolibrary.org/obo/UBERON_0035198	superficial lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		The tubules that carry lymph throughout the body that are just beneath the surface of the skin.
http://purl.obolibrary.org/obo/UBERON_0035545	deep lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		The tubules that carry lymph throughout the body that are in the interior of the body or limbs.
http://purl.obolibrary.org/obo/UBERON_0035549	vasculature of integument	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin.
http://purl.obolibrary.org/obo/UBERON_0035551	deep vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin.
http://purl.obolibrary.org/obo/UBERON_0035552	deep vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery.
http://purl.obolibrary.org/obo/UBERON_0035597	profundal placode	http://purl.obolibrary.org/obo/UBERON_0009955	neurogenic placode		An embryonic structure positioned halfway between the prospective eye and ear, adjacent to the future midbrain-hindbrain boundary. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24.
http://purl.obolibrary.org/obo/UBERON_0035642	laryngeal nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		Any nerve that innervates the larynx.
http://purl.obolibrary.org/obo/UBERON_0035648	nerve innervating pinna	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		Any nerve that innervates the pinna.
http://purl.obolibrary.org/obo/UBERON_0035652	fibular nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		Any nerve that innervates the fibularis. Includes the common fibular nerve, and its branches.
http://purl.obolibrary.org/obo/UBERON_0035776	accessory ciliary ganglion	http://purl.obolibrary.org/obo/UBERON_0035783	ganglion of ciliary nerve		A parasympathetic ganglion located on the short ciliary nerve differentiated from the main ciliary ganglion by virtue of the fact that it had no root derived directly from the inferior trunk of the oculomotor nerve and it never attaches to this nerve.
http://purl.obolibrary.org/obo/UBERON_0035783	ganglion of ciliary nerve	http://purl.obolibrary.org/obo/UBERON_0001808	parasympathetic ganglion		Any parasympathetic ganglion that extends fibers into the short ciliary nerve. Includes both the main and acccessory ciliary ganglia.
http://purl.obolibrary.org/obo/HP_0020041	Double elevator palsy	http://purl.obolibrary.org/obo/HP_0025068	Incomitant strabismus		A type of incomitant strabismus in which both elevator muscles (i.e., the inferior oblique and superior rectus muscles) of the same eye are weak leading to restricted elevation and hypotropia.
http://purl.obolibrary.org/obo/HP_0020042	Double depressor palsy	http://purl.obolibrary.org/obo/HP_0025068	Incomitant strabismus		An ocular movement abnormality characterized by simultaneous weakness of the inferior rectus muscle and superior oblique muscle of the same eye.
http://purl.obolibrary.org/obo/HP_0020043	Vertical incomitant strabismus	http://purl.obolibrary.org/obo/HP_0025068	Incomitant strabismus		A type of incomitant strabismus in which the angle of deviation varies as the patient's gaze shifts upwards and/or downwards.
http://purl.obolibrary.org/obo/HP_0020046	Accommodative esotropia	http://purl.obolibrary.org/obo/HP_0000565	Esotropia		A form of esotropia (convergent deviation of the eyes) associated with activation of the accommodative reflex.
http://purl.obolibrary.org/obo/HP_0020047	Abnormal myeloid cell morphology	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		Any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
http://purl.obolibrary.org/obo/HP_0020048	Reduced bone-marrow pro-B cell count	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		A reduction in the numbers of pro-B cells (defined by coexpression of CD34 and CD19). Earlier B-cell precursors are defined by expressing surface CD34 and cytoplasmic TdT in the absence of CD19.
http://purl.obolibrary.org/obo/HP_0020050	Anti-granulocyte-macrophage colony stimulating factor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against granulocyte-macrophage colony stimulating factor.
http://purl.obolibrary.org/obo/HP_0025559	Coronary cataract	http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract		A type of cataract characterized by club-shaped and dot opacities distributed radially in the deep cortex. These lens opacities surround the nucleus in an appearance that is though to resemble a crown.
http://purl.obolibrary.org/obo/HP_0025560	Anterior chamber cells	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		Tiny deposits corresponding to cells floating in the anterior chamber of the eye. This appearance is typically associated with intraocular inflammation leading to breakdown of the blood-aqueous barrier and resulting in an increase in the number of cells and in the aqueous humor. Grading (SUN Working Group) is performed by estimating the number of cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.
http://purl.obolibrary.org/obo/HP_0025561	Anterior chamber cells grade 1+	http://purl.obolibrary.org/obo/HP_0025560	Anterior chamber cells		Anterior chamber cells with 6-15 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.
http://purl.obolibrary.org/obo/HP_0025563	Anterior chamber cells grade 0	http://purl.obolibrary.org/obo/HP_0025560	Anterior chamber cells		Anterior chamber cells with less than one cell in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.
http://purl.obolibrary.org/obo/HP_0025564	Anterior chamber cells grade 2+	http://purl.obolibrary.org/obo/HP_0025560	Anterior chamber cells		Anterior chamber cells with 16-25 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.
http://purl.obolibrary.org/obo/HP_0025565	Anterior chamber cells grade 3+	http://purl.obolibrary.org/obo/HP_0025560	Anterior chamber cells		Anterior chamber cells with 26-50 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.
http://purl.obolibrary.org/obo/HP_0025566	Anterior chamber cells grade 4+	http://purl.obolibrary.org/obo/HP_0025560	Anterior chamber cells		Anterior chamber cells with more than 50 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.
http://purl.obolibrary.org/obo/HP_0025567	Central serous chorioretinopathy	http://purl.obolibrary.org/obo/HP_0000532	Abnormal chorioretinal morphology		An anomaly of the retina with serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE), and associated with blurred vision, usually in one eye only and perceived typically by the patient as a dark spot in the center of the visual field with associated micropsia and metamorphopsia. Normal vision often recurs spontaneously within a few months.
http://purl.obolibrary.org/obo/HP_0025569	Polypoidal choroidal vasculopathy	http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology		The presence of aneurysmal 'polypoidal' lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization.
http://purl.obolibrary.org/obo/HP_0025570	Choroidal vascular hyperpermeability	http://purl.obolibrary.org/obo/HP_0030605	Abnormal indocyanine green angiography		Increased tendency of choiroidal blood vessels to allow fluids to leak characterized by multifocal choroidal hyperfluorescence on indocyanine green angiography (ICGA).
http://purl.obolibrary.org/obo/HP_0025573	Mild myopia	http://purl.obolibrary.org/obo/HP_0000545	Myopia		A mild form of myopia with up to -3.00 diopters.
http://purl.obolibrary.org/obo/HP_0025574	Macular hemorrhage	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		Bleeding occurring within the macula lutea of the retina.
http://purl.obolibrary.org/obo/HP_0025578	Aortic valve prolapse	http://purl.obolibrary.org/obo/HP_0001646	Abnormal aortic valve morphology		Aortic valve prolapse can be diagnosed when either or both of the right or non-coronary aortic valve cusps (seen in the cross sectional echocardiographic long axis view) show backward bowing towards the left ventricle beyond a line joining the points of attachment of the aortic valve leaflets to the annulus.
http://purl.obolibrary.org/obo/HP_0025580	Abnormal right atrium morphology	http://purl.obolibrary.org/obo/HP_0005120	Abnormal cardiac atrium morphology		Any structural abnormality of the right atrium.
http://purl.obolibrary.org/obo/HP_0025581	Foveal hemorrhage	http://purl.obolibrary.org/obo/HP_0025574	Macular hemorrhage		Bleeding occurring within the fovea.
http://purl.obolibrary.org/obo/HP_0025582	Submacular hemorrhage	http://purl.obolibrary.org/obo/HP_0025243	Subretinal hemorrhage		Bleeding between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation.
http://purl.obolibrary.org/obo/HP_0025583	Tapetal-like fundal reflex	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Golden, scintillating, particulate reflection noted on fundus examination (typically in the macula and sparing the fovea). The term tapetal is used to describe this 'metallic' sheen appearance as it is thought to be similar to the 'tapetal' reflex seen in the eyes of certain animals.
http://purl.obolibrary.org/obo/HP_0025584	Hypotropia	http://purl.obolibrary.org/obo/HP_0025588	Hypodeviation		A form of manifest strabismus (heterotropia) in which one eye is deviated downwards when both eyes are open.
http://purl.obolibrary.org/obo/HP_0025585	Hyperphoria	http://purl.obolibrary.org/obo/HP_0025587	Hyperdeviation		Tendency for the visual axis of one eye to be higher than that of the other.
http://purl.obolibrary.org/obo/HP_0025586	Hypertropia	http://purl.obolibrary.org/obo/HP_0025587	Hyperdeviation		A type of strabismus characterized by permanent upward deviation of the visual axis of one eye.
http://purl.obolibrary.org/obo/HP_0025588	Hypodeviation	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		A type of strabismus in which the visual axis of one eye is lower than that of the other.
http://purl.obolibrary.org/obo/HP_0025589	Cyclodeviation	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		Cyclodeviation is defined as the rotation of an eyeball along the anteroposterior axis and cyclotropia as a misalignment of cyclodeviation between the two eyes.
http://purl.obolibrary.org/obo/HP_0025590	Abnormal extraocular muscle physiology	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		A functional anomaly of the muscles of the eye.
http://purl.obolibrary.org/obo/HP_0025591	Abnormal superior oblique muscle physiology	http://purl.obolibrary.org/obo/HP_0031739	Abnormal oblique muscle physiology		A functional anomaly of the superior oblique muscle, a fusiform muscle that originates in the upper, medial side of the orbit. The superior oblique muscle abducts, depresses and internally rotates the eye, and is the only extraocular muscle innervated by the fourth cranial nerve.
http://purl.obolibrary.org/obo/HP_0025592	Superior oblique muscle weakness	http://purl.obolibrary.org/obo/HP_0025591	Abnormal superior oblique muscle physiology		Decreased strength of the superior oblique muscle.
http://purl.obolibrary.org/obo/HP_0025593	Superior oblique muscle restriction	http://purl.obolibrary.org/obo/HP_0025592	Superior oblique muscle weakness		Mechanical limitation of the range of movement of the superior oblique muscle.
http://purl.obolibrary.org/obo/HP_0025594	Superior oblique muscle overaction	http://purl.obolibrary.org/obo/HP_0025591	Abnormal superior oblique muscle physiology		An ocular motility abnormality characterized by an overacting superior oblique muscle resulting to vertical incomitance of the eyes in lateral gaze. On examination, this is commonly seen as a downshoot of the adducting eye occurring when gaze is directed into the field of action of the inferior oblique muscle, producing a greater downward excursion of the adducted eye than of the abducted eye.
http://purl.obolibrary.org/obo/HP_0025595	Superior oblique muscle underaction	http://purl.obolibrary.org/obo/HP_0025592	Superior oblique muscle weakness		Reduced ocular movement of the superior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy.
http://purl.obolibrary.org/obo/HP_0025596	Abnormal inferior oblique muscle physiology	http://purl.obolibrary.org/obo/HP_0031739	Abnormal oblique muscle physiology		A functional anomaly of the inferior oblique muscle, an extraocular muscle that has its origin on the maxillary bone just posterior to the inferior medial orbital rim and lateral to the nasolacrimal canal and that is innervated by the inferior branch of the oculomotor nerve.
http://purl.obolibrary.org/obo/HP_0025597	Inferior oblique muscle restriction	http://purl.obolibrary.org/obo/HP_0025598	Inferior oblique muscle weakness		Mechanical limitation of the range of movement of the inferior oblique muscle.
http://purl.obolibrary.org/obo/HP_0025598	Inferior oblique muscle weakness	http://purl.obolibrary.org/obo/HP_0025596	Abnormal inferior oblique muscle physiology		Decreased strength of the inferior oblique muscle.
http://purl.obolibrary.org/obo/HP_0025599	Inferior oblique muscle overaction	http://purl.obolibrary.org/obo/HP_0025596	Abnormal inferior oblique muscle physiology		A common ocular motility disorder characterized by vertical incomitance of the eyes in lateral gaze. In primary inferior oblique muscle overaction, an upshoot of the adducting eye occurs when gaze is directed into the field of action of the inferior oblique muscle, producing a greater upward excursion of the adducted eye than of the abducted eye.
http://purl.obolibrary.org/obo/HP_0025600	Abnormal inferior rectus muscle physiology	http://purl.obolibrary.org/obo/HP_0031748	Abnormal vertical rectus muscle physiology		A functional anomaly of the inferior rectus muscle, which is innervated by the inferior division of oculomotor nerve and functions in the depression, adduction, and lateral rotation (extortion) of the eye.
http://purl.obolibrary.org/obo/HP_0025601	Inferior rectus muscle weakness	http://purl.obolibrary.org/obo/HP_0025600	Abnormal inferior rectus muscle physiology		Decreased strength of the inferior rectus muscle.
http://purl.obolibrary.org/obo/HP_0025602	Inferior rectus muscle restriction	http://purl.obolibrary.org/obo/HP_0025601	Inferior rectus muscle weakness		Mechanical limitation of the range of movement of the inferior rectus muscle.
http://purl.obolibrary.org/obo/HP_0025603	Abnormal superior rectus muscle physiology	http://purl.obolibrary.org/obo/HP_0031748	Abnormal vertical rectus muscle physiology		A functional anomaly of the superior rectus muscle, an extraocular muscle that is innervated by the superior division of the oculomotor nerve, and whose primary function is the elevation of the globe.
http://purl.obolibrary.org/obo/HP_0025604	Orbital schwannoma	http://purl.obolibrary.org/obo/HP_0100012	Neoplasm of the eye		A schwannoma (benign, usually encapsulated slow growing tumor composed of Schwann cells) located in the orbit.
http://purl.obolibrary.org/obo/HP_0025605	Lid lag on downgaze	http://purl.obolibrary.org/obo/HP_0031785	Abnormal eyelid movement		Delayed descent of the upper eyelid on downgaze. Also described by some authors as von Graefe sign.
http://purl.obolibrary.org/obo/HP_0025606	Abnormal medial rectus muscle physiology	http://purl.obolibrary.org/obo/HP_0031740	Abnormal horizontal rectus muscle physiology		A functional anomaly of the medial rectus muscle, an extraocular muscle that is innervated by the inferior division of the oculomotor nerve and whose sole action is the adduction of the eyeball.
http://purl.obolibrary.org/obo/HP_0025607	Upper eyelid entropion	http://purl.obolibrary.org/obo/HP_0000621	Entropion		An inward turning (inversion) of the margin of the upper eyelid.
http://purl.obolibrary.org/obo/HP_0025608	Cicatricial ectropion	http://purl.obolibrary.org/obo/HP_0000656	Ectropion		An outward turning (eversion) or rotation of the eyelid margin (i.e., ectropion) caused by shortening or contraction of the anterior or middle lamellae related to scarring.
http://purl.obolibrary.org/obo/HP_0025609	Anterior blepharitis	http://purl.obolibrary.org/obo/HP_0000498	Blepharitis		A type of blepharitis that affects the eyelid skin, base of the eyelashes, and the eyelash follicles.
http://purl.obolibrary.org/obo/HP_0025610	Posterior blepharitis	http://purl.obolibrary.org/obo/HP_0000498	Blepharitis		A type of blepharitis that affects the meibomian glands and meibomian gland orifices. This abnormality can be associated with a spectrum of appearances ranging from meibomian seborrhoea (foaming meibomian gland secretions) and meibomianitis (inflamed meibomian glands), to chalazia.
http://purl.obolibrary.org/obo/HP_0025611	Epicanthus superciliaris	http://purl.obolibrary.org/obo/HP_0000286	Epicanthus		A type of epicanthus in which more extensive epicanthal folds with their origins in the eyebrow cover, pass in front of and lateral to the medial canthus (middle corner of the eye).
http://purl.obolibrary.org/obo/HP_0025612	Corneal astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		A type of refractive error related abnormal curvatures on the anterior or posterior surface of the cornea.
http://purl.obolibrary.org/obo/HP_0031611	Sub-inner limiting membrane hemorrhage	http://purl.obolibrary.org/obo/HP_0000573	Retinal hemorrhage		A type of intraretinal hemorrhage that is located in the superficial retina between the inner limiting membrane and the retinal nerve fiber layer.
http://purl.obolibrary.org/obo/HP_0031613	Inferior chorioretinal coloboma	http://purl.obolibrary.org/obo/HP_0000567	Chorioretinal coloboma		Absence of a region of the retina, retinal pigment epithelium, and choroid at the lower part of the fundus.
http://purl.obolibrary.org/obo/HP_0031614	Inferior retinal coloboma	http://purl.obolibrary.org/obo/HP_0000480	Retinal coloboma		A notch or cleft of the lower part of the retina.
http://purl.obolibrary.org/obo/HP_0031615	Hypopyon	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		Presence of pus (appears as a white fluid) producing a fluid level in the inferior part of the anterior chamber.
http://purl.obolibrary.org/obo/HP_0031616	Anterior chamber flare	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		An abnormal appearance of the beam of light traveling through the anterior chamber of the eye in a slit lamp examination. The flare is produced by an increased concentration of proteins in the aqueous humor in the anterior chamber.
http://purl.obolibrary.org/obo/HP_0031618	Anterior chamber flare grade 1+	http://purl.obolibrary.org/obo/HP_0031616	Anterior chamber flare		Faint anterior chamber flare.
http://purl.obolibrary.org/obo/HP_0031619	Anterior chamber flare grade 2+	http://purl.obolibrary.org/obo/HP_0031616	Anterior chamber flare		Moderate anterior chamber flare (iris and lens details clear).
http://purl.obolibrary.org/obo/HP_0031620	Anterior chamber flare grade 3+	http://purl.obolibrary.org/obo/HP_0031616	Anterior chamber flare		Marked anterior chamber flare (iris and lens details hazy).
http://purl.obolibrary.org/obo/HP_0031621	Anterior chamber flare grade 4+	http://purl.obolibrary.org/obo/HP_0031616	Anterior chamber flare		Intense anterior chamber flare (fibrin/plastic aqueous).
http://purl.obolibrary.org/obo/HP_0031622	Brown anomaly	http://purl.obolibrary.org/obo/HP_0025068	Incomitant strabismus		An ocular motility defect where the affected eye(s) does not elevate in adduction but has full depression in adduction. It can be congenital or acquired from injury to or defect of the superior oblique tendon or trochlea and has a positive forced duction test result.
http://purl.obolibrary.org/obo/HP_0031623	Brow ptosis	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		Drooping of the upper eyebrow below the superior orbital rim.
http://purl.obolibrary.org/obo/HP_0031624	Moderate myopia	http://purl.obolibrary.org/obo/HP_0000545	Myopia		A moderate form of myopia with refractive error of between -3.00 and -6.00 diopters.
http://purl.obolibrary.org/obo/HP_0031625	Pseudoaneurysm	http://purl.obolibrary.org/obo/HP_0002617	Vascular dilatation		A contained rupture of an artery with a disruption in all 3 layers of the arterial wall.
http://purl.obolibrary.org/obo/HP_0031626	Coronary ostial atresia	http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin		Absence of the normal opening of a coronary ostium. There are normally two coronary ostia, which are site of origin of the main left or right main coronary artery and are located in the ascending aorta just above the aortic valve.
http://purl.obolibrary.org/obo/HP_0031627	Globus pallidus calcification	http://purl.obolibrary.org/obo/HP_0002453	Abnormal globus pallidus morphology		Pathological deposition of calcium salts in the globus pallidus.
http://purl.obolibrary.org/obo/HP_0031628	Aborted sudden cardiac death	http://purl.obolibrary.org/obo/HP_0001695	Cardiac arrest		Cardiac arrest that would have led to rapid and unexpected death had an intervention not taken place to prevent it.
http://purl.obolibrary.org/obo/HP_0031629	Impaired tandem gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Reduced ability to walk in a straight line while placing the feet heel to toe.
http://purl.obolibrary.org/obo/HP_0031630	Abnormal subpleural morphology	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		Any structural anomaly located between the pleura and the chest wall.
http://purl.obolibrary.org/obo/HP_0031631	Subpleural honeycombing	http://purl.obolibrary.org/obo/HP_0031630	Abnormal subpleural morphology		So-called honeycombs (variably sized cysts in a background of densely scarred tissue) located in the subpleural space.
http://purl.obolibrary.org/obo/HP_0031632	Aberrant right subclavian artery	http://purl.obolibrary.org/obo/HP_0031251	Abnormal subclavian artery morphology		Abnormal origin of the right subclavian artery from the descending aorta. The right subclavian artery normally arises from the brachiocephalic trunk, which divides into the right common carotid artery and right subclavian artery.
http://purl.obolibrary.org/obo/HP_0031633	Isolation of the left subclavian artery	http://purl.obolibrary.org/obo/HP_0031251	Abnormal subclavian artery morphology		The loss of continuity between the left subclavian artery and the aorta, with persistent connection to the homolateral pulmonary artery through the patent (PDA) or nonpatent ductus arteriosus.
http://purl.obolibrary.org/obo/HP_0031634	Anomalous origin of the left common carotid artery from the main pulmonary artery	http://purl.obolibrary.org/obo/HP_0430021	Abnormal common carotid artery morphology		The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the main pulmonary artery.
http://purl.obolibrary.org/obo/HP_0031635	Anomalous origin of the left common carotid artery from the brachiocephalic artery	http://purl.obolibrary.org/obo/HP_0430021	Abnormal common carotid artery morphology		The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the brachiocephalic artery.
http://purl.obolibrary.org/obo/HP_0031636	Anomalous origin of the right common carotid artery from the aorta	http://purl.obolibrary.org/obo/HP_0430021	Abnormal common carotid artery morphology		The right common carotid artery normally originates from the brachiocephalic artery. This term refers to an origin of this artery directly from the aorta.
http://purl.obolibrary.org/obo/HP_0031637	Right coronary artery ostial atresia	http://purl.obolibrary.org/obo/HP_0031626	Coronary ostial atresia		Absence of the normal opening of the coronary ostium from which the right main coronary artery originates.
http://purl.obolibrary.org/obo/HP_0031638	Anomalous origin of the left anterior descending artery from the pulmonary artery	http://purl.obolibrary.org/obo/HP_0011637	Anomalous origin of coronary artery from the pulmonary artery		The left anterior descending artery (LAD) branches off from the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0031639	Absent left main coronary artery	http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin		The left main coronary artery (LMCA) is absent and the left anterior descending (LAD) and left circumflex (LCX) arteries arise from separate but adjacent ostia in the left sinus of Valsava.
http://purl.obolibrary.org/obo/HP_0031640	Abnormal radial artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any structural anomaly of the radial artery.
http://purl.obolibrary.org/obo/HP_0031643	Fusiform ascending tubular aorta aneurysm	http://purl.obolibrary.org/obo/HP_0004970	Ascending tubular aorta aneurysm		A concentric abnormal localized widening (dilatation) of the ascending tubular aorta that involves the full circumference of the vessel wall.
http://purl.obolibrary.org/obo/HP_0031644	Fusiform abdominal aortic aneurysm	http://purl.obolibrary.org/obo/HP_0005112	Abdominal aortic aneurysm		A concentric abnormal localized widening (dilatation) of the abdominal aorta that involves the full circumference of the vessel wall
http://purl.obolibrary.org/obo/HP_0031645	Saccular abdominal aortic aneurysm	http://purl.obolibrary.org/obo/HP_0005112	Abdominal aortic aneurysm		An eccentric abnormal localized widening (dilatation) of the abdominal aorta that involves only a portion of the circumference of the vessel wall.
http://purl.obolibrary.org/obo/HP_0031646	Fusiform aortic arch aneurysm	http://purl.obolibrary.org/obo/HP_0005113	Aortic arch aneurysm		A concentric abnormal localized widening (dilatation) of the aortic arch that involves the full circumference of the vessel wall.
http://purl.obolibrary.org/obo/HP_0031647	Saccular aortic arch aneurysm	http://purl.obolibrary.org/obo/HP_0005113	Aortic arch aneurysm		An eccentric abnormal localized widening (dilatation) of the aortic arch that involves only a portion of the circumference of the vessel wall.
http://purl.obolibrary.org/obo/HP_0031648	Penetrating aortic ulcer	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		A focal defect in the elastic lamina of the aortic wall that leads to localized medial disruption and potential rupture.
http://purl.obolibrary.org/obo/HP_0031649	Aortic rupture	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Tearing of the aortic wall generally associated with profuse internal bleeding.
http://purl.obolibrary.org/obo/HP_0031650	Abnormal atrioventricular valve physiology	http://purl.obolibrary.org/obo/HP_0031653	Abnormal heart valve physiology		Any functional defect of the mitral or tricuspid valve.
http://purl.obolibrary.org/obo/HP_0031653	Abnormal heart valve physiology	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Any functional abnormality of a cardiac valve.
http://purl.obolibrary.org/obo/HP_0031655	Quadricuspid aortic valve	http://purl.obolibrary.org/obo/HP_0031567	Abnormal aortic valve cusp morphology		The presence of an aortic valve with four instead of the normal three cusps (flaps).
http://purl.obolibrary.org/obo/HP_0031656	Systolic anterior motion of the mitral valve	http://purl.obolibrary.org/obo/HP_0031481	Abnormal mitral valve physiology		Systolic anterior motion of the mitral valve (SAM) is a paradoxical motion of the anterior, and occasionally posterior, mitral valve leaflet towards the left ventricular outflow tract (LVOT) during systole.
http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Any abnormal noise generated by the beating heart.
http://purl.obolibrary.org/obo/HP_0031658	Third heart sound	http://purl.obolibrary.org/obo/HP_0033113	Gallop rhythm		The third heart sound (S3) is related to rapid filling in diastole. S3 can be a normal finding in children and adolescents but suggests heart failure in older patients.
http://purl.obolibrary.org/obo/HP_0031659	Fourth heart sound	http://purl.obolibrary.org/obo/HP_0033113	Gallop rhythm		The fourth heart sound (S4) is a low-pitched sound that occurs just before the first heart sound (S1) when the atria contract to force blood into the left ventricle, that is, coincident with late diastolic filling of the ventricle due to atrial contraction.
http://purl.obolibrary.org/obo/HP_0031660	Loud first heart sound	http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound		Abnormally increased volume of the first heart sound.
http://purl.obolibrary.org/obo/HP_0031661	Abnormal second heart sound	http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound		Any anomaly of the second heart sound (S2), which is produced by aortic (A2) and pulmonic (P2) valve closure. The A2-P2 interval normally increases with inspiration and narrows with expiration.
http://purl.obolibrary.org/obo/HP_0031662	Fixed splitting of the second heart sound	http://purl.obolibrary.org/obo/HP_0031661	Abnormal second heart sound		Lack of variation in the splitting between the two components of the second heart sound with respiration. Normally, the aortic valve closure (A2) is followed by the pulmonic valve closure (P2) but the A2-P2 interval increases with inspiration and decreases with expiration.
http://purl.obolibrary.org/obo/HP_0031663	Paradoxical splitting of the second heart sound	http://purl.obolibrary.org/obo/HP_0031661	Abnormal second heart sound		Normally, the aortic valve closure (A2) is followed by the pulmonic valve closure (P2) but the A2-P2 interval increases with inspiration and decreases with expiration. With paradoxical splitting, there is a delay in the closure of the aortic valve, so that A2 can follow P2; the individual components can be appreciated at the end of expiration and the interval narrows with inspiration (which is the opposite of the normal pattern).
http://purl.obolibrary.org/obo/HP_0031664	Systolic heart murmur	http://purl.obolibrary.org/obo/HP_0030148	Heart murmur		A heart murmur limited to systole, i.e., between the first and second heart sounds S1 and S2.
http://purl.obolibrary.org/obo/HP_0031665	Midsystolic murmur	http://purl.obolibrary.org/obo/HP_0031664	Systolic heart murmur		A systolic murmur that begins after S1 and ends before S2, typically with a crescendo-decrescendo pattern.
http://purl.obolibrary.org/obo/HP_0031666	Late systolic murmur	http://purl.obolibrary.org/obo/HP_0031664	Systolic heart murmur		A murmur that occurs in the latter phase of systole.
http://purl.obolibrary.org/obo/HP_0031667	Holosystolic murmur	http://purl.obolibrary.org/obo/HP_0031664	Systolic heart murmur		A heart murmur that occurs during the entire systolic phase from S1 to S2.
http://purl.obolibrary.org/obo/HP_0031668	Diastolic heart murmur	http://purl.obolibrary.org/obo/HP_0030148	Heart murmur		A heart murmur that occurs during diastole, i.e., in the time between S2 and the subsequent S1.
http://purl.obolibrary.org/obo/HP_0031669	Middiastolic murmur	http://purl.obolibrary.org/obo/HP_0031668	Diastolic heart murmur		A murmur that occurs in the middle of the diastolic phase.
http://purl.obolibrary.org/obo/HP_0031670	Continuous heart murmur	http://purl.obolibrary.org/obo/HP_0030148	Heart murmur		A murmur that occurs in both systole and diastole.
http://purl.obolibrary.org/obo/HP_0031671	Typical atrial flutter	http://purl.obolibrary.org/obo/HP_0004749	Atrial flutter		Typical atrial flutter is an organized atrial tachycardia. It can also be defined as a macroreentrant tachycardia confined to the right atrium. This arrhythmia has a 200-260 ms cycle length, although it may fluctuate depending on patient's previous treatment or ablation, congenital heart disease, etc. Ventricular rate response will be limited by the atrioventricular node conductions, usually presenting a 2:1 or 3:1 response, during atrial flutter. Typical (counter clockwise) flutter is associated with the common flutter pattern: a regular continuous undulation with dominant negative deflections in inferior leads II, III and aVF, often described also as a saw tooth pattern, and flat atrial deflections in leads I and aVL. Atrial deflections in V1 can be positive, biphasic or negative.
http://purl.obolibrary.org/obo/HP_0031672	Reverse typical atrial flutter	http://purl.obolibrary.org/obo/HP_0004749	Atrial flutter		A type of atrial flutter associated with rounded or bimodal positive deflections in inferior leads II, III and aVF, and a very characteristic bimodal negative wave in the shape of a W is seen in lead V1.
http://purl.obolibrary.org/obo/HP_0031673	Orthodromic atrioventricular reentrant tachycardia	http://purl.obolibrary.org/obo/HP_0011717	Atrioventricular reentrant tachycardia		A type of atrioventricular reentrant tachycardia (AVRT) where the atrioventricular node is used for anterograde conduction and the accessory pathway for retrograde conduction.
http://purl.obolibrary.org/obo/HP_0031674	Antidromic atrioventricular reentrant tachycardia	http://purl.obolibrary.org/obo/HP_0011717	Atrioventricular reentrant tachycardia		A type of atrioventricular reentrant tachycardia (AVRT) where the accessory pathway is used for anterograde conduction and the atrioventricular node for retrograde conduction.
http://purl.obolibrary.org/obo/HP_0031675	Fascicular left ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004756	Ventricular tachycardia		A ventricular tachycardia (VT) characterized by right bundle branch block (RBBB) and left axis deviation (LAD) on electrocardiogram (ECG).
http://purl.obolibrary.org/obo/HP_0031676	Monomorphic ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004756	Ventricular tachycardia		A type of ventricular tachycardia that is characterized by uniform QRS complexes within each lead (i.e., each QRS is identical or nearly so).
http://purl.obolibrary.org/obo/HP_0031677	Polymorphic ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004756	Ventricular tachycardia		A type of ventricular tachycardia that is characterized by variable QRS complexes within each lead (i.e., QRS complexes may be different from beat to beat).
http://purl.obolibrary.org/obo/HP_0031679	Type I atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0031678	Atherosclerotic lesion		Type I lesions represent the very initial changes and are recognized as an increase in the number of intimal macrophages and the appearance of macrophages filled with lipid droplets (foam cells).
http://purl.obolibrary.org/obo/HP_0031680	Type II atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0031678	Atherosclerotic lesion		Type II atherosclerotic lesions include the fatty streak lesion, the first grossly visible lesion, and are characterized by layers of macrophage foam cells and lipid droplets within intimal smooth muscle cells and minimal coarse-grained particles and heterogeneous droplets of extracellular lipid.
http://purl.obolibrary.org/obo/HP_0031681	Type III atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0031678	Atherosclerotic lesion		Type III (intermediate) atherosclerotic lesions are the morphological and chemical bridge between type II and advanced lesions. Type III lesions appear in some adaptive intimal thickenings (progression-prone locations) in young adults and are characterized by pools of extracellular lipid in addition to all the components of type II lesions.
http://purl.obolibrary.org/obo/HP_0031682	Type V atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0031678	Atherosclerotic lesion		Type V lesions are defined as lesions in which prominent new fibrous connective tissue has formed. When the new tissue is part of a lesion with a lipid core (type IV), this type of morphology may be referred to as fibroatheroma or type Va lesion. A type V lesion in which the lipid core and other parts of the lesion are calcified may be referred to as type Vb. A type V lesion in which a lipid core is absent and lipid in general is minimal may be referred to as type Vc. With these lesions, arteries are variously narrowed, generally more than with type IV. Importantly, as with type IV lesions, type V lesions may develop fissures, hematoma, and/or thrombus (type VI lesion), and for this reason too they are clinically relevant.
http://purl.obolibrary.org/obo/HP_0031683	Type VI atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0031678	Atherosclerotic lesion		Type VI atherosclerotic lesions generally have the underlying morphology of type IV or V lesions, surface disruptions, hematoma, and thrombosis may be (although less often) superimposed on any other type of lesion and even on intima without an apparent lesion. Complicating features may arise because of individual differences in risk factors and tissue reactions. These may include differences in composition of the blood, the relative quantities and distributions in the components of the underlying lesion or intima, as well as modifications of shear and tensile forces to which the lesion or intima is exposed. Clinical imaging of lesions may be expected to contribute greatly to the understanding of type VI lesions and the associated clinical syndromes.
http://purl.obolibrary.org/obo/HP_0031684	Renal artery atherosclerosis	http://purl.obolibrary.org/obo/HP_0008776	Abnormal renal artery morphology		An atherosclerotic lesion located in the renal artery.
http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition	http://purl.obolibrary.org/obo/HP_0025033	Abnormal digestive system morphology		Abnormal level of metabolite or other abnormal analyte result in a stool test.
http://purl.obolibrary.org/obo/HP_0031686	Increased stool alpha1-antitrypsin concentration	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		An abnormally elevated amount of alpha1-antitrypsin in the feces.
http://purl.obolibrary.org/obo/HP_0031688	Erythroid dysplasia	http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology		Dysplasia in the erythroid lineage, which presents with a variety of morphological changes in the bone marrow, including nuclear budding or irregular nuclear contour in erythroblasts.
http://purl.obolibrary.org/obo/HP_0031689	Megakaryocyte dysplasia	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		The presence of micro-megakaryocytes, hypo-lobed, or non-lobed nuclei in megakaryocytes of all sizes and multiple, widely-separated nuclei.
http://purl.obolibrary.org/obo/HP_0031691	Severe viral infection	http://purl.obolibrary.org/obo/HP_0032169	Severe infection		An unusually severe viral infection.
http://purl.obolibrary.org/obo/HP_0031692	Severe cytomegalovirus infection	http://purl.obolibrary.org/obo/HP_5210146	Unusual cytomegalovirus infection		An unusually severe infection by cytomegalovirus.
http://purl.obolibrary.org/obo/HP_0031693	Severe Epstein Barr virus infection	http://purl.obolibrary.org/obo/HP_5210286	Unusual EBV infection		An unusually severe Epstein Barr virus (EBV) infection.
http://purl.obolibrary.org/obo/HP_0031694	Severe adenovirus infection	http://purl.obolibrary.org/obo/HP_5210101	Unusual adenovirus infection		An unusually severe adenovirus infection.
http://purl.obolibrary.org/obo/HP_0031695	Severe parainfluenza infection	http://purl.obolibrary.org/obo/HP_5210323	Unusual parainfluenza infection		Increased susceptibility to parainfluenza virus infections as manifested by a severe or invasive infection with parainfluenza virus.
http://purl.obolibrary.org/obo/HP_0031696	Disseminated viral infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		A viral infection that fails to be contained by the immune system and spreads throughout the body.
http://purl.obolibrary.org/obo/HP_0031697	Disseminated infection with live vaccine virus	http://purl.obolibrary.org/obo/HP_0031696	Disseminated viral infection		A dissemination viral infection caused by a live attenuated vaccine virus.
http://purl.obolibrary.org/obo/HP_0031699	Disseminated cryptosporidium infection	http://purl.obolibrary.org/obo/HP_0031690	Opportunistic infection		Disseminated infection with Cryptosporidium species, involving organs beyond the gastrointestinal tract such as the biliary tree, respiratory tract, or pancreas.
http://purl.obolibrary.org/obo/HP_0031700	Invasive parasitic infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		A parasitic infection whereby the parasite invades (migrates through) tissues of the infected host.
http://purl.obolibrary.org/obo/HP_0031701	Anterior chamber inflammatory cells	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		The presence of inflammatory cells in the aqueous humor of the anterior chamber of the eye.
http://purl.obolibrary.org/obo/HP_0031702	Anterior chamber red blood cells	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		The presence of erythrocyte in the aqueous humor of the anterior chamber of the eye.
http://purl.obolibrary.org/obo/HP_0031706	Compensatory chin depression	http://purl.obolibrary.org/obo/HP_0031705	Compensatory head posture		A tendency to hold the chin depressed (lowered) to compensate for a limitation of eye movement.
http://purl.obolibrary.org/obo/HP_0031707	Compensatory face turn to the right	http://purl.obolibrary.org/obo/HP_0031705	Compensatory head posture		A tendency to turn the face to the right to compensate for a limitation of eye movement.
http://purl.obolibrary.org/obo/HP_0031708	Compensatory face turn to the left	http://purl.obolibrary.org/obo/HP_0031705	Compensatory head posture		A tendency to turn the face to the left to compensate for a limitation of eye movement.
http://purl.obolibrary.org/obo/HP_0031709	Compensatory head tilt to the right shoulder	http://purl.obolibrary.org/obo/HP_0031705	Compensatory head posture		A tendency to tilt the head towards the right shoulder to compensate for a limitation of eye movement.
http://purl.obolibrary.org/obo/HP_0031710	Compensatory head tilt to the left shoulder	http://purl.obolibrary.org/obo/HP_0031705	Compensatory head posture		A tendency to tilt the head towards the left shoulder to compensate for a limitation of eye movement.
http://purl.obolibrary.org/obo/HP_0031713	Constant exotropia	http://purl.obolibrary.org/obo/HP_0000577	Exotropia		A form of divergent strabismus (exotropia) in which the eye turns outward at all distances and at all times.
http://purl.obolibrary.org/obo/HP_0031714	Distance exotropia	http://purl.obolibrary.org/obo/HP_0000577	Exotropia		A type of divergent strabismus (exotropia) in which an eye tends to turn outwards (i.e., the eye squints) mainly when looking at distant objects. The eyes tend to remain straight when they look at near objects. Distance exotropia may be constant or intermittent.
http://purl.obolibrary.org/obo/HP_0031715	Near exotropia	http://purl.obolibrary.org/obo/HP_0000577	Exotropia		An intermittent exotropia where there is binocular single vision on distance fixation and exotropia at near (intermittent or constant).
http://purl.obolibrary.org/obo/HP_0031716	Cyclic exotropia	http://purl.obolibrary.org/obo/HP_0000577	Exotropia		A type of exotropia (divergent strabismus) in which binocular single vision alternates with large angle exotropia in rhythmic cycle.
http://purl.obolibrary.org/obo/HP_0031717	Alternating exotropia	http://purl.obolibrary.org/obo/HP_0000577	Exotropia		A type of exotropia in which either eye may be used for fixation.
http://purl.obolibrary.org/obo/HP_0031718	Consecutive exotropia	http://purl.obolibrary.org/obo/HP_0000577	Exotropia		Exotropia in an individual who has previously had esotropia or esophoria.
http://purl.obolibrary.org/obo/HP_0031719	True distance exotropia	http://purl.obolibrary.org/obo/HP_0031714	Distance exotropia		Exotropia (intermittent or constant) on distance fixation with binocular single vision on near fixation under all testing conditions. The accommodative convergence/accommodation (AC:A) ratio is within normal limits.
http://purl.obolibrary.org/obo/HP_0031720	Simulated distance exotropia	http://purl.obolibrary.org/obo/HP_0031714	Distance exotropia		Exotropia (intermittent or constant) worse for distance fixation in which the near angle of deviation increases (or near exophoria becomes exotropia) with: (1) prolonged disruption of fusion and/or (2) elimination of accommodation.
http://purl.obolibrary.org/obo/HP_0031721	Sensory exotropia	http://purl.obolibrary.org/obo/HP_0000577	Exotropia		A type of divergent strabismus (exotropia) that develops in a poorly seeing eye.
http://purl.obolibrary.org/obo/HP_0031722	Near esotropia	http://purl.obolibrary.org/obo/HP_0031760	Non-accomodative esotropia		An intermittent esotropia where there is binocular single vision on distance fixation and esotropia at near even when the accommodation is relieved.
http://purl.obolibrary.org/obo/HP_0031723	Secondary esotropia	http://purl.obolibrary.org/obo/HP_0000565	Esotropia		Convergent squint which follows loss or impairment of vision.
http://purl.obolibrary.org/obo/HP_0031724	Microtropia	http://purl.obolibrary.org/obo/HP_0032012	Heterotropia		A small angle heterotropia (usually of 10 diopters or less) in which a form of binocular single vision occurs.
http://purl.obolibrary.org/obo/HP_0031725	Hypophoria	http://purl.obolibrary.org/obo/HP_0025588	Hypodeviation		A form of latent strabismus (heterophoria) in which, on dissociation, the occluded eye deviates downwards.
http://purl.obolibrary.org/obo/HP_0031726	Incyclotropia	http://purl.obolibrary.org/obo/HP_0031776	Cyclotropia		A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated inward (medially) to each other.
http://purl.obolibrary.org/obo/HP_0031728	Mild hypermetropia	http://purl.obolibrary.org/obo/HP_0000540	Hypermetropia		A form of hypermetropia with not more than +2.00 diopters.
http://purl.obolibrary.org/obo/HP_0031729	Moderate hypermetropia	http://purl.obolibrary.org/obo/HP_0000540	Hypermetropia		A form of hypermetropia with more than +2.00 diopters but not more than +5.00 diopters.
http://purl.obolibrary.org/obo/HP_0031730	Axial myopia	http://purl.obolibrary.org/obo/HP_0000545	Myopia		A form of myopia related to an axial length above the norm and too long for the refractive power of the whole optical system of the eye.
http://purl.obolibrary.org/obo/HP_0031731	Increased tear production	http://purl.obolibrary.org/obo/HP_0009926	Epiphora		Increased lacrimation owing to overproduction of tears.
http://purl.obolibrary.org/obo/HP_0031732	Increased basal tear production	http://purl.obolibrary.org/obo/HP_0031731	Increased tear production		A form of watery eye associated with overproduction of tears due to an increased parasympathetic drive to the secretory component of the lacrimal system (lacrimal gland); this could be due to pro-secretory drug use (e.g. pilocarpine) or autonomic disturbance.
http://purl.obolibrary.org/obo/HP_0031733	Reflex tearing	http://purl.obolibrary.org/obo/HP_0031731	Increased tear production		A form of watery eye associated with overproduction of tears due to reflex tearing in response to a local irritant (e.g. trichiasis or foreign body), chronic ocular surface disease (e.g. blepharitis) or systemic disease (e.g. thyroid eye disease).
http://purl.obolibrary.org/obo/HP_0031734	Lacrimal pump failure	http://purl.obolibrary.org/obo/HP_0009926	Epiphora		A form of watery eye associated with abnormal lid tone and/or lid position. The former is due to lid laxity (common involutional change in the elderly) or a weak orbicularis muscle (e.g. due to VII cranial nerve palsy). The latter is typically associated with ectropion causing punctal eversion.
http://purl.obolibrary.org/obo/HP_0031736	Involutional entropion	http://purl.obolibrary.org/obo/HP_0000621	Entropion		An abnormal inversion of the eyelid towards the globe resulting from inferior retractor muscle dysfunction with tissue laxity and, possibly, overriding of the preseptal orbicularis muscle over the pretarsal orbicularis muscle.
http://purl.obolibrary.org/obo/HP_0031737	Cicatricial entropion	http://purl.obolibrary.org/obo/HP_0000621	Entropion		Abnormal inversion (turning inward) of the eyelid towards the globe associated with scarring that vertically shortens the posterior lamella of the eyelid.
http://purl.obolibrary.org/obo/HP_0031738	Mechanical entropion	http://purl.obolibrary.org/obo/HP_0000621	Entropion		A type of entropion (abnormal inversion of the eyelid towards the globe) that is related to a mass effect of a lesion (e.g., a tumor) that pulls the eyelid margin away from the globe.
http://purl.obolibrary.org/obo/HP_0031739	Abnormal oblique muscle physiology	http://purl.obolibrary.org/obo/HP_0025590	Abnormal extraocular muscle physiology		A functional anomaly of the inferior or superior oblique muscle.
http://purl.obolibrary.org/obo/HP_0031740	Abnormal horizontal rectus muscle physiology	http://purl.obolibrary.org/obo/HP_0031755	Abnormal rectus muscle physiology		A functional anomaly of the medial rectus muscle or lateral rectus muscle.
http://purl.obolibrary.org/obo/HP_0031741	Inferior oblique muscle underaction	http://purl.obolibrary.org/obo/HP_0025598	Inferior oblique muscle weakness		Reduced ocular movement by the inferior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy.
http://purl.obolibrary.org/obo/HP_0031742	Inferior rectus muscle underaction	http://purl.obolibrary.org/obo/HP_0025601	Inferior rectus muscle weakness		Reduced movement by the inferior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.
http://purl.obolibrary.org/obo/HP_0031743	Inferior rectus muscle overaction	http://purl.obolibrary.org/obo/HP_0025600	Abnormal inferior rectus muscle physiology		Excessive action of the inferior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.
http://purl.obolibrary.org/obo/HP_0031744	Superior rectus muscle weakness	http://purl.obolibrary.org/obo/HP_0025603	Abnormal superior rectus muscle physiology		Decreased strength of the superior rectus muscle.
http://purl.obolibrary.org/obo/HP_0031745	Superior rectus muscle overaction	http://purl.obolibrary.org/obo/HP_0025603	Abnormal superior rectus muscle physiology		Excessive action of the superior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.
http://purl.obolibrary.org/obo/HP_0031746	Superior rectus muscle restriction	http://purl.obolibrary.org/obo/HP_0031744	Superior rectus muscle weakness		Mechanical limitation of the range of movement of the superior rectus muscle.
http://purl.obolibrary.org/obo/HP_0031747	Superior rectus muscle underaction	http://purl.obolibrary.org/obo/HP_0031744	Superior rectus muscle weakness		Reduced movement of the superior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.
http://purl.obolibrary.org/obo/HP_0031748	Abnormal vertical rectus muscle physiology	http://purl.obolibrary.org/obo/HP_0031755	Abnormal rectus muscle physiology		A functional anomaly of the superior or inferior rectus muscle.
http://purl.obolibrary.org/obo/HP_0031749	Abnormal lateral rectus muscle physiology	http://purl.obolibrary.org/obo/HP_0031740	Abnormal horizontal rectus muscle physiology		A functional anomaly of the lateral rectus muscle.
http://purl.obolibrary.org/obo/HP_0031750	Lateral rectus muscle weakness	http://purl.obolibrary.org/obo/HP_0031749	Abnormal lateral rectus muscle physiology		Decreased strength (ability to move) of the lateral rectus muscle.
http://purl.obolibrary.org/obo/HP_0031751	Lateral rectus muscle underaction	http://purl.obolibrary.org/obo/HP_0031750	Lateral rectus muscle weakness		Reduced movement of the lateral rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.
http://purl.obolibrary.org/obo/HP_0031752	Lateral rectus muscle overaction	http://purl.obolibrary.org/obo/HP_0031749	Abnormal lateral rectus muscle physiology		Excessive action of the lateral rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.
http://purl.obolibrary.org/obo/HP_0031753	Medial rectus muscle weakness	http://purl.obolibrary.org/obo/HP_0025606	Abnormal medial rectus muscle physiology		Decreased strength of the medial rectus muscle.
http://purl.obolibrary.org/obo/HP_0031754	Medial rectus muscle overaction	http://purl.obolibrary.org/obo/HP_0025606	Abnormal medial rectus muscle physiology		Excessive action of the medial rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.
http://purl.obolibrary.org/obo/HP_0031755	Abnormal rectus muscle physiology	http://purl.obolibrary.org/obo/HP_0025590	Abnormal extraocular muscle physiology		A functional anomaly of a vertical or horizontal rectus muscle.
http://purl.obolibrary.org/obo/HP_0031756	Medial rectus muscle underaction	http://purl.obolibrary.org/obo/HP_0031753	Medial rectus muscle weakness		Reduced movement of the medial rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.
http://purl.obolibrary.org/obo/HP_0031757	Medial rectus muscle restriction	http://purl.obolibrary.org/obo/HP_0031753	Medial rectus muscle weakness		Mechanical limitation of the range of movement of the medial rectus muscle.
http://purl.obolibrary.org/obo/HP_0031758	Lateral rectus muscle restriction	http://purl.obolibrary.org/obo/HP_0031750	Lateral rectus muscle weakness		Mechanical limitation of the range of movement of the lateral rectus muscle.
http://purl.obolibrary.org/obo/HP_0031759	Basic constant esotropia	http://purl.obolibrary.org/obo/HP_0031760	Non-accomodative esotropia		A form of convergent strabismus (esotropia) in which the deviation is present under all conditions (ie at all distances and at all times).
http://purl.obolibrary.org/obo/HP_0031760	Non-accomodative esotropia	http://purl.obolibrary.org/obo/HP_0000565	Esotropia		A form of esotropia in which the angle of deviation is not affected by accommodative effort.
http://purl.obolibrary.org/obo/HP_0031761	Infantile constant esotropia	http://purl.obolibrary.org/obo/HP_0031760	Non-accomodative esotropia		Constant esotropia occurring before 6 months of age. It is typically associated with a large angle of deviation, alternating fixation (therefore low risk of amblyopia) and poor potential for binocular single vision. Other features that might be present in individuals with infantile (constant) esotropia include latent nystagmus or manifest latent nystagmus, dissociated vertical divergence, cyclotropia, abnormal head posture, limited abduction.
http://purl.obolibrary.org/obo/HP_0031762	Distance esotropia	http://purl.obolibrary.org/obo/HP_0031760	Non-accomodative esotropia		An intermittent esotropia where binocular single vision is present on near fixation and an esotropia on distance fixation. Often associated with myopia and aging.
http://purl.obolibrary.org/obo/HP_0031763	Cyclic esotropia	http://purl.obolibrary.org/obo/HP_0031760	Non-accomodative esotropia		Convergent strabismus in which normal binocular single vision is alternating with large angle esotropia in rhythmic cycle.
http://purl.obolibrary.org/obo/HP_0031764	Fully accomodative esotropia	http://purl.obolibrary.org/obo/HP_0020046	Accommodative esotropia		Esotropia in which normal binocular single vision is present for all distances when the hypermetropic refractive error is corrected. Esotropia is present for near and distance on accommodation without correction.
http://purl.obolibrary.org/obo/HP_0031765	Partially accomodative esotropia	http://purl.obolibrary.org/obo/HP_0020046	Accommodative esotropia		A form of constant esotropia in which the angle of deviation is partially affected by accommodative effort. Typically there is esotropia at near and distance with hypermetropic correction and the angle of deviation increases without glasses.
http://purl.obolibrary.org/obo/HP_0031766	Convergence excess esotropia	http://purl.obolibrary.org/obo/HP_0020046	Accommodative esotropia		An intermittent esotropia with binocular single vision present at distance fixation but esotropia on accommodation for near fixation. Usually associated with hypermetropia but patients can be emmetropic and rarely myopic. Associated with a high accommodative convergence/accommodation (AC/A) ratio.
http://purl.obolibrary.org/obo/HP_0031767	Consecutive esotropia	http://purl.obolibrary.org/obo/HP_0000565	Esotropia		Esotropia in a patient who has previously had exotropia or exophoria; may be constant or intermittent and usually follows surgical overcorrection.
http://purl.obolibrary.org/obo/HP_0031768	Parafoveal fixation	http://purl.obolibrary.org/obo/HP_0025549	Eccentric visual fixation		Fixation of an object in the area adjacent to the fovea.
http://purl.obolibrary.org/obo/HP_0031769	Peripheral fixation	http://purl.obolibrary.org/obo/HP_0025549	Eccentric visual fixation		Fixation of an object in a peripheral area of the retina.
http://purl.obolibrary.org/obo/HP_0031770	Epicanthus palpebralis	http://purl.obolibrary.org/obo/HP_0000286	Epicanthus		A type of epicanthus in which a medial vertical fold is present between upper and lower lids.
http://purl.obolibrary.org/obo/HP_0031771	Epicanthus tarsalis	http://purl.obolibrary.org/obo/HP_0000286	Epicanthus		A type of epicanthus in which a primarily upper lid fold is present.
http://purl.obolibrary.org/obo/HP_0040328	Focal hyperintensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0030890	Hyperintensity of cerebral white matter on MRI		An abnormal area of increased brightness (hyperintensity) that is limited to one particular area.
http://purl.obolibrary.org/obo/HP_0040329	Multifocal hyperintensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0030890	Hyperintensity of cerebral white matter on MRI		An abnormal area of increased brightness (hyperintensity) that occurs in several distinct areas.
http://purl.obolibrary.org/obo/HP_0040330	Confluent hyperintensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0030890	Hyperintensity of cerebral white matter on MRI		Areas of brighter than expected MRI signal in the white matter of the brain whereby individual patches run together.
http://purl.obolibrary.org/obo/HP_0500033	Abnormal natural killer subset distribution	http://purl.obolibrary.org/obo/HP_0012176	Abnormal natural killer cell morphology		Any abnormality in the proportion natural killer subsets relative to the total number of natural killer cells.
http://purl.obolibrary.org/obo/HP_0031784	Abnormal ascending aorta morphology	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise.
http://purl.obolibrary.org/obo/GO_0110110	positive regulation of animal organ morphogenesis	http://purl.obolibrary.org/obo/GO_2000027	regulation of animal organ morphogenesis		Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.
http://purl.obolibrary.org/obo/GO_0110111	negative regulation of animal organ morphogenesis	http://purl.obolibrary.org/obo/GO_2000027	regulation of animal organ morphogenesis		Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis.
http://purl.obolibrary.org/obo/HP_0031910	Abnormal cranial nerve physiology	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		A functional abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.
http://purl.obolibrary.org/obo/HP_0031917	Digital ulcer	http://purl.obolibrary.org/obo/HP_0200042	Skin ulcer		An open sore on the surface of the skin of a finger or toe.
http://purl.obolibrary.org/obo/HP_0031941	Abnormal portal venous system morphology	http://purl.obolibrary.org/obo/HP_0006707	Abnormality of the hepatic vasculature		Any structural anomaly of the portal venous system, which comprises all of the veins draining the abdominal part of the digestive tract, including the lower esophagus but excluding the lower anal canal. The portal vein conveys blood from viscera and ramifies like an artery at the liver, ending at the sinusoids. Tributaries of the portal vein, which make up the portal venous system, are the splenic, superior mesenteric, left gastric, right gastric, paraumbilical, and cystic veins.
http://purl.obolibrary.org/obo/CHEBI_25978	phenylacetic acids	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		Any monocarboxylic acid that is phenylacetic acid or its substituted derivatives.
http://purl.obolibrary.org/obo/CHEBI_142767	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-yl group	http://purl.obolibrary.org/obo/CHEBI_30697	beta-D-glucosyl group		A β-<small>D</small>-glucosyl group derived from the trisaccharide <em>N</em>-acetyl-α-neuraminyl-(2→3)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucose.  Implied reactive epitope within ganglioside GM3.
http://purl.obolibrary.org/obo/CHEBI_149498	(7Z,10Z,13Z,16Z)-docosatetraenoyl derivative	http://purl.obolibrary.org/obo/CHEBI_61697	fatty acid derivative		An entity derived from (7<i>Z</i>,10<i>Z</i>,13<i>Z</i>,16<i>Z</i>)-docosatetraenoic acid where the R is not defined.
http://purl.obolibrary.org/obo/HP_0033062	Abnormal factor IX activity	http://purl.obolibrary.org/obo/HP_0010989	Abnormality of the intrinsic pathway		Abnormal activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.
http://purl.obolibrary.org/obo/HP_0033072	Abnormal macroscopic urine appearance	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		Anomalous physical appearance (color, cloudiness, clarity) or odor of urine.
http://purl.obolibrary.org/obo/HP_0033079	Aplasia/Hypoplasia of the thyroid gland	http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology		Absence or underdevelopment of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0033259	Non-motor seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A seizure with clinical manifestation but without motor signs (other than possible behavior arrest) as its initial clinical manifestation. The electrographic onset may be generalized, focal, or unknown.
http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Any abnormal sttructure of the glomerular basement membrane.
http://purl.obolibrary.org/obo/HP_0033331	Acute phase response	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Presence of one or more manifestations of the acute phase response. Acute phase proteins (APP) are blood proteins primarily synthesized by hepatocytes as part of the acute phase response (APR). The APR is part of the early-defense or innate immune system, which is triggered by different stimuli including trauma, infection, stress, neoplasia, and inflammation. The APR results in a complex systemic reaction with the goal of reestablishing homeostasis and promoting healing.
http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology	http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology		Any structural anomaly of a blood vessel (artery, arteriole, capillary, venule, or vein).
http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		Any deviation from the normal amount of a metabolite in urine.
http://purl.obolibrary.org/obo/HP_0033358	Abnormal urine osmolality	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		A deviation from the normal range of concentration of particles in urine.
http://purl.obolibrary.org/obo/CHEBI_173085	ferroptosis inducer	http://purl.obolibrary.org/obo/CHEBI_52206	biochemical role		Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
http://purl.obolibrary.org/obo/GO_0120305	regulation of pigmentation	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.
http://purl.obolibrary.org/obo/HP_0033859	Abnormal peritubular capillary morphology	http://purl.obolibrary.org/obo/HP_0033835	Abnormal renal vascular morphology		Anomalous structure of the capillaries that are derived from the efferent arteriole, forming a capillary network that surrounds the distal portions of the nephron tubule,
http://purl.obolibrary.org/obo/HP_0033860	Abnormal cortical peritubular capillary morphology	http://purl.obolibrary.org/obo/HP_0033859	Abnormal peritubular capillary morphology		Anomalous structure of the peritubular capillaries located in the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0033861	Multilamellation of cortical peritubular capillary basement membranes	http://purl.obolibrary.org/obo/HP_0033860	Abnormal cortical peritubular capillary morphology		Duplicated basement membranes of the peritubular capillaries located in the cortex of the kidney and arranged in multiple concentric layers.
http://purl.obolibrary.org/obo/HP_0033862	Cortical peritubular capillaritis	http://purl.obolibrary.org/obo/HP_0033860	Abnormal cortical peritubular capillary morphology		Inflammation of the peritubular capillaries in the cortex of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells.
http://purl.obolibrary.org/obo/HP_0033863	Abnormal cortical peritubular capillary lumen morphology	http://purl.obolibrary.org/obo/HP_0033860	Abnormal cortical peritubular capillary morphology		Abnormal structural characteristics of the interior space of the peritubular capillary in the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0033864	Abnormal medullary peritubular capillary morphology	http://purl.obolibrary.org/obo/HP_0033859	Abnormal peritubular capillary morphology		Anomalous structure of the peritubular capillaries located in the medulla of the kidney.
http://purl.obolibrary.org/obo/HP_0033865	Medullary peritubular capillaritis	http://purl.obolibrary.org/obo/HP_0033864	Abnormal medullary peritubular capillary morphology		Inflammation of the peritubular capillaries in the medulla of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells.
http://purl.obolibrary.org/obo/HP_0033866	Medullary peritubular capillary erythrocyte congestion	http://purl.obolibrary.org/obo/HP_0033864	Abnormal medullary peritubular capillary morphology		Substantially increased numbers of red blood cells within capillaries surrounding tubules in the medulla of the kidney. This feature is assessed in histological images as the presence of numerous erythrocytes in a segment of the capillary such that the vessel appears to be congested (not open).
http://purl.obolibrary.org/obo/HP_0033867	Multilamellation of medullary peritubular capillary basement membranes	http://purl.obolibrary.org/obo/HP_0033864	Abnormal medullary peritubular capillary morphology		Duplicated basement membranes of the peritubular capillaries located in the medulla of the kidney and arranged in multiple concentric layers.
http://purl.obolibrary.org/obo/HP_0033868	Abnormal medullary peritubular capillary lumen morphology	http://purl.obolibrary.org/obo/HP_0033864	Abnormal medullary peritubular capillary morphology		Abnormal structural characteristics of the interior space of the peritubular capillary in the medulla of the kidney.
http://purl.obolibrary.org/obo/HP_0033869	Medullary peritubular capillary lumen cholesterol emboli	http://purl.obolibrary.org/obo/HP_0033868	Abnormal medullary peritubular capillary lumen morphology		Needle-like or slit-like clefts within the interior space of peritubular capillaries located in the medulla of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.
http://purl.obolibrary.org/obo/HP_0033870	Medullary peritubular capillary intraluminal thrombi	http://purl.obolibrary.org/obo/HP_0033868	Abnormal medullary peritubular capillary lumen morphology		Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the peritubular capillaries located in the medulla of the kidney.
http://purl.obolibrary.org/obo/HP_0033871	Medullary peritubular capillary lumen organized thrombi	http://purl.obolibrary.org/obo/HP_0033868	Abnormal medullary peritubular capillary lumen morphology		Thrombi containing fibrous tissue and capillary-like vascular channels located within the lumen of the peritubular capillaries of the medulla of the kidney.
http://purl.obolibrary.org/obo/HP_0033872	Cortical peritubular capillary lumen cholesterol emboli	http://purl.obolibrary.org/obo/HP_0033863	Abnormal cortical peritubular capillary lumen morphology		Needle-like or slit-like clefts within the interior space of peritubular capillaries located in the cortex of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.
http://purl.obolibrary.org/obo/HP_0033873	Cortical peritubular capillary intraluminal thrombi	http://purl.obolibrary.org/obo/HP_0033863	Abnormal cortical peritubular capillary lumen morphology		Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the peritubular capillaries located in the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0033874	Cortical peritubular capillary lumen organized thrombi	http://purl.obolibrary.org/obo/HP_0033863	Abnormal cortical peritubular capillary lumen morphology		Thrombi containing fibrous tissue and capillary-like vascular channels located within the lumen of the peritubular capillaries of the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0033875	Abnormal arcuate vein lumen morphology	http://purl.obolibrary.org/obo/HP_0033853	Abnormal arcuate vein morphology		Abnormal structural characteristics of the interior space (lumen) of the arcuate vein of the kidney.
http://purl.obolibrary.org/obo/HP_0033876	Arcuate vein lumen cholesterol emboli	http://purl.obolibrary.org/obo/HP_0033875	Abnormal arcuate vein lumen morphology		Needle-like or slit-like clefts within the interior space of arcuate veins of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.
http://purl.obolibrary.org/obo/HP_0033877	Arcuate vein intraluminal thrombi	http://purl.obolibrary.org/obo/HP_0033875	Abnormal arcuate vein lumen morphology		Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033878	Arcuate vein lumen organized thrombi	http://purl.obolibrary.org/obo/HP_0033875	Abnormal arcuate vein lumen morphology		Thrombi containing fibrous tissue and capillary-like vascular channels located within the lumen of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology	http://purl.obolibrary.org/obo/HP_0033853	Abnormal arcuate vein morphology		Any structural anomaly located in the inner or middle layer of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033880	Arcuate vein intimal mucoid edema	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Accumulation of edematous extracellular matrix in the inner layer (intima) of arcuate veins of the kidney. The material resembles mucus and appears pale blue on hematoxylin and eosin staining.
http://purl.obolibrary.org/obo/HP_0033881	Arcuate vein intimal/medial myxomatous degeneration	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Accumulation of myxoid material (mucus-like material) within the inner or middle layer of the arcuate vein of the kidney.
http://purl.obolibrary.org/obo/HP_0033882	Arcuate vein intima/medial amyloidosis	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Amorphous extracellular substance in the inner or middle layer of the arcuate veins of the kidney. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy.
http://purl.obolibrary.org/obo/HP_0033883	Abnormal cortical radial artery morphology	http://purl.obolibrary.org/obo/HP_0033836	Abnormal intrarenal artery morphology		Any structural anomaly of the radial arteries that branch off at right angles from the arcuate artery and carry blood toward the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0033884	Abnormal cortical radial artery lumen morphology	http://purl.obolibrary.org/obo/HP_0033883	Abnormal cortical radial artery morphology		Abnormal structural characteristics of the interior space of the cortical radial arteries of the kidney.
http://purl.obolibrary.org/obo/HP_0033885	Cortical radial artery lumen cholesterol emboli	http://purl.obolibrary.org/obo/HP_0033884	Abnormal cortical radial artery lumen morphology		Needle-like or slit-like clefts within the interior space of cortical radial arteries (interlobular arteries) of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.
http://purl.obolibrary.org/obo/HP_0033886	Abnormal arcuate artery intima/media morphology	http://purl.obolibrary.org/obo/HP_0033837	Abnormal arcuate artery morphology		Anomalous structure of the inner or middle layer of the arc-shaped arteries located at the border of the renal cortex and renal medulla.
http://purl.obolibrary.org/obo/HP_0033887	Cortical radial artery intimal/medial amyloidosis	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular arteries of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy
http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology	http://purl.obolibrary.org/obo/HP_0033883	Abnormal cortical radial artery morphology		Any structural anomaly of the inner or middle layer of the cortical radial arteries (also known as interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033889	Abnormal renal arteriole morphology	http://purl.obolibrary.org/obo/HP_0033835	Abnormal renal vascular morphology		Any structural anomaly of the glomerular arterioles. The interlobar arteries of the kidney branch into arcuate arteries, cortical radiate arteries, and then into afferent arterioles. After passing through the renal corpuscle, the capillaries form the efferent arteriole. The afferent and efferent arterioles are difficult to distinguish histologically and are thus both included in this term and its descendents.
http://purl.obolibrary.org/obo/HP_0033890	Abnormal renal arteriole lumen morphology	http://purl.obolibrary.org/obo/HP_0033889	Abnormal renal arteriole morphology		Abnormal structural characteristics of the interior space (lumen) of renal arterioles.
http://purl.obolibrary.org/obo/HP_0033891	Renal arteriolar lumen cholesterol emboli	http://purl.obolibrary.org/obo/HP_0033890	Abnormal renal arteriole lumen morphology		Needle-like or slit-like clefts within the interior space of arterioles of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.
http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology	http://purl.obolibrary.org/obo/HP_0033889	Abnormal renal arteriole morphology		Any structural anomaly located in the inner or middle layer of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033893	Renal arteriolar lumen organized thrombi	http://purl.obolibrary.org/obo/HP_0033890	Abnormal renal arteriole lumen morphology		Thrombi containing fibrous tissue and capillary-like vascular channels located within the lumen of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033894	Renal arteriolar intraluminal thrombi	http://purl.obolibrary.org/obo/HP_0033890	Abnormal renal arteriole lumen morphology		Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033895	Abnormal renal arteriole endothelium morphology	http://purl.obolibrary.org/obo/HP_0033889	Abnormal renal arteriole morphology		Any structural anomaly of the lining (endothelium) of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033896	Abnormal arcuate artery lumen morphology	http://purl.obolibrary.org/obo/HP_0033837	Abnormal arcuate artery morphology		Abnormal structural characteristics of the interior space (lumen) of the arcuate artery of the kidney.
http://purl.obolibrary.org/obo/HP_0033897	Arcuate artery lumen cholesterol emboli	http://purl.obolibrary.org/obo/HP_0033896	Abnormal arcuate artery lumen morphology		Needle-like or slit-like clefts within the interior space of arcuate arteries of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.
http://purl.obolibrary.org/obo/HP_0033898	Arcuate artery intraluminal thrombi	http://purl.obolibrary.org/obo/HP_0033896	Abnormal arcuate artery lumen morphology		Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arcuate arteries of the kidney.
http://purl.obolibrary.org/obo/HP_0033899	Arcuate artery lumen organized thrombi	http://purl.obolibrary.org/obo/HP_0033896	Abnormal arcuate artery lumen morphology		Thrombi containing fibrous tissue and capillary-like vascular channels located within the lumen of the arcuate arteries of the kidney.
http://purl.obolibrary.org/obo/HP_0033900	Renal arteriole intima/media amyloidosis	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Amorphous extracellular substance in the inner or middle layer of renal arterioles. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy.
http://purl.obolibrary.org/obo/HP_0033901	Abnormal arcuate artery endothelium morphology	http://purl.obolibrary.org/obo/HP_0033837	Abnormal arcuate artery morphology		Any structural anomaly of the lining (endothelium) of the arcuate arteries of the kidney.
http://purl.obolibrary.org/obo/HP_0033902	Arcuate artery endotheliosis	http://purl.obolibrary.org/obo/HP_0033901	Abnormal arcuate artery endothelium morphology		Enlargement of endothelial cells of the arcuate arteries of the kidney because of cytoplasmic swelling.
http://purl.obolibrary.org/obo/HP_0033903	Arcuate artery endoarterial hypercellularity	http://purl.obolibrary.org/obo/HP_0033901	Abnormal arcuate artery endothelium morphology		Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the arcuate arteries of the kidney.
http://purl.obolibrary.org/obo/HP_0033904	Renal arteriole intima/media hyalinosis	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material (hyalinosis) in the inner or middle layer of the renal arterioles. This feature may be accompanied by hypertrophy of the media and intima fibrosis.
http://purl.obolibrary.org/obo/HP_0033905	Arcuate artery intima/media arteriosclerosis	http://purl.obolibrary.org/obo/HP_0033886	Abnormal arcuate artery intima/media morphology		Thickening of the intima of the arcuate arteries of the kidney with fibrosis and/or duplication of the elastic lamina.
http://purl.obolibrary.org/obo/HP_0033906	Renal intimal/medial arteriolitis	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Inflammation of an arteriole of the kidney, which may involve only the intma or can be transmural.
http://purl.obolibrary.org/obo/HP_0033907	Renal arteriole intima/media arteriolosclerosis	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Thickening of the intima of renal arterioles with fibrosis and/or duplication of the elastic lamina.
http://purl.obolibrary.org/obo/HP_0033908	Renal arteriole medial atrophy	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Atrophy (wasting, decreased thickness) of of the middle layer of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033909	Arcuate vein medial hypertrophy	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Increased thickness of middle layer of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033910	Arcuate vein medial atrophy	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Atrophy (wasting, decreased thickness) of the middle layer of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033911	Cortical radial artery medial hypertrophy	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Increased thickness of the middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033912	Cortical radial artery medial atrophy	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Atrophy (wasting, decreased thickness) of the middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033913	Cortical radial artery medial/intimal arteriitis	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Inflammation of a the intima or the entire wall of cortical radial arteries (also known as the interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033914	Arcuate artery intima/media amyloidosis	http://purl.obolibrary.org/obo/HP_0033886	Abnormal arcuate artery intima/media morphology		Amorphous extracellular substance in the inner or middle layer of the arcuate arteries of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy.
http://purl.obolibrary.org/obo/HP_0033915	Arcuate artery intimal mucoid edema	http://purl.obolibrary.org/obo/HP_0033886	Abnormal arcuate artery intima/media morphology		Accumulation of edematous extracellular matrix in intima resembling mucus. This feature appears pale blue on hematoxylin and eosin staining.
http://purl.obolibrary.org/obo/HP_0033916	Medial/intimal arcuate venosclerosis	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Thickening of the intima with fibrosis and/or duplication of the elastic lamina in arcuate veins.
http://purl.obolibrary.org/obo/HP_0033917	Arcuate intimal/medial venulitis	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Inflammation of the inner or middle layer of arcuate venules. This feature may involve only the intima or it can be transmural.
http://purl.obolibrary.org/obo/HP_0033918	Renal arteriole medial hypertrophy	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Increased thickness of middle layer of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033920	Renal arteriole intima/media storage material accumulation	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Deposition of storage material other than amyloid (glycogen, glycosphingolipid in Fabry's disease, sphingomyelin in Nieman Pick disease, glucosylceramide in Gaucher's disease, gangliosides, mucopolysaccahrides, phytanic acid in Refsum disease) in the inner or middle layer of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033921	Renal arteriole endoarterial hypercellularity	http://purl.obolibrary.org/obo/HP_0033895	Abnormal renal arteriole endothelium morphology		Abnormal and excessive number of cells (hypercellularity) in the lining (endothelium) of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033922	Renal arteriole leukocytic endoarterial hypercellularity	http://purl.obolibrary.org/obo/HP_0033921	Renal arteriole endoarterial hypercellularity		A type of renal arteriole endoarterial hypercellularity due to increased number of white blood cells (leukocytes).
http://purl.obolibrary.org/obo/HP_0033923	Renal arteriole foam cell endoarterial hypercellularity	http://purl.obolibrary.org/obo/HP_0033922	Renal arteriole leukocytic endoarterial hypercellularity		A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen.
http://purl.obolibrary.org/obo/HP_0033924	Renal arteriole neutrophil endoarterial hypercellularity	http://purl.obolibrary.org/obo/HP_0033922	Renal arteriole leukocytic endoarterial hypercellularity		A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of increased numbers of neutrophils within the arteriolar lumen.
http://purl.obolibrary.org/obo/HP_0033925	Renal arteriole lymphocyte endoarterial hypercellularity	http://purl.obolibrary.org/obo/HP_0033922	Renal arteriole leukocytic endoarterial hypercellularity		A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of increased number of lymphocytes in the arteriolar lumen.
http://purl.obolibrary.org/obo/HP_0033926	Renal arteriole intimal/medial multilamellation	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Myointimal hyperplasia arranged in multiple concentric layers in the inner or middle layer of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033927	Arcuate artery endoarterial leukocyte hypercellularity	http://purl.obolibrary.org/obo/HP_0033903	Arcuate artery endoarterial hypercellularity		Arcuate artery endoarterial hypercellularity due to increased numbers of white blood cells (leukocytes).
http://purl.obolibrary.org/obo/HP_0033928	Arcuate artery endoarterial foam cell hypercellularity	http://purl.obolibrary.org/obo/HP_0033927	Arcuate artery endoarterial leukocyte hypercellularity		A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen.
http://purl.obolibrary.org/obo/HP_0033929	Arcuate artery endoarterial neutrophil hypercellularity	http://purl.obolibrary.org/obo/HP_0033927	Arcuate artery endoarterial leukocyte hypercellularity		A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased numbers of neutrophils withinin the lumen of arcuate artery.
http://purl.obolibrary.org/obo/HP_0033930	Arcuate artery endoarterial lymphocyte hypercellularity	http://purl.obolibrary.org/obo/HP_0033927	Arcuate artery endoarterial leukocyte hypercellularity		A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of arcuate artery.
http://purl.obolibrary.org/obo/HP_0033931	Arcuate artery intima/media necrosis	http://purl.obolibrary.org/obo/HP_0033886	Abnormal arcuate artery intima/media morphology		Death of tissue in the inner or middle layer of the arcuate artery of the kidney.
http://purl.obolibrary.org/obo/HP_0033932	Arcuate artery intima/media coagulative necrosis	http://purl.obolibrary.org/obo/HP_0033931	Arcuate artery intima/media necrosis		A type of arcuate artery intima/media necrosis in which the necrotic tissue retains the outlines of the dead (necrotic) structures.
http://purl.obolibrary.org/obo/HP_0033933	Arcuate artery intima/media liquefactive necrosis	http://purl.obolibrary.org/obo/HP_0033931	Arcuate artery intima/media necrosis		A type of arcuate artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.
http://purl.obolibrary.org/obo/HP_0033934	Arcuate vein intimal/medial storage material accumulation	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Accumulation of material other than amyloid (glycogen, glycosphingolipid in Fabry's disease, sphingomyelin in Nieman Pick disease, glucosylceramide in Gaucher's disease, gangliosides, mucopolysaccahrides, phytanic acid in Refsum disease) in the inner or middle layer of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033935	Cortical radial artery intima/media necrosis	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Cell death (necrosis) in the inner or middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033936	Cortical radial artery intima/media liquefactive necrosis	http://purl.obolibrary.org/obo/HP_0033935	Cortical radial artery intima/media necrosis		A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.
http://purl.obolibrary.org/obo/HP_0033937	Cortical radial artery intima/media coagulative necrosis	http://purl.obolibrary.org/obo/HP_0033935	Cortical radial artery intima/media necrosis		A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.
http://purl.obolibrary.org/obo/HP_0033938	Renal arteriole intima/media necrosis	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Cell death (necrosis) in the inner or middle layer of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033939	Renal arteriole intima/media liquefactive necrosis	http://purl.obolibrary.org/obo/HP_0033938	Renal arteriole intima/media necrosis		A type of renal arteriole intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.
http://purl.obolibrary.org/obo/HP_0033940	Renal arteriole intima/media coagulative necrosis	http://purl.obolibrary.org/obo/HP_0033938	Renal arteriole intima/media necrosis		A type of renal arteriole intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.
http://purl.obolibrary.org/obo/HP_0033941	Granulomatous arteriolitis of the arteriolar intima/media	http://purl.obolibrary.org/obo/HP_0033906	Renal intimal/medial arteriolitis		A type of renal intimal/medial arteriolitis characteriezed by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries.
http://purl.obolibrary.org/obo/HP_0033942	Arcuate vein medial/intimal necrosis	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Cell death (necrosis) of the inner or middle layer of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033943	Arcuate vein medial/intimal coagulative necrosis	http://purl.obolibrary.org/obo/HP_0033942	Arcuate vein medial/intimal necrosis		A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.
http://purl.obolibrary.org/obo/HP_0033944	Arcuate vein medial/intimal liquefactive necrosis	http://purl.obolibrary.org/obo/HP_0033942	Arcuate vein medial/intimal necrosis		A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.
http://purl.obolibrary.org/obo/HP_0033945	Arcuate intimal/medial granulomatous venulitis	http://purl.obolibrary.org/obo/HP_0033917	Arcuate intimal/medial venulitis		A type of arcuate intimal/medial venulitis characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins.
http://purl.obolibrary.org/obo/HP_0033946	Arcuate vein intima/media crystal accumulation	http://purl.obolibrary.org/obo/HP_0033879	Abnormal arcuate vein intima/media morphology		Deposition of crystals such as uric acid, oxalate, or cystine in the inner or middle layer of the arcuate veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033947	Renal arteriole intima/media crystal accumulation	http://purl.obolibrary.org/obo/HP_0033892	Abnormal renal arteriole intima/media morphology		Deposition of crystals such as uric acid, oxalate, or cystine in the inner or middle layer of the arterioles of the kidney.
http://purl.obolibrary.org/obo/HP_0033948	Arcuate artery intima/media arteriitis	http://purl.obolibrary.org/obo/HP_0033886	Abnormal arcuate artery intima/media morphology		Inflammation of the inner or middle layer of the arcuate arteries of the kidney.
http://purl.obolibrary.org/obo/HP_0033949	Arcuate artery intima/media granulomatous arteriitis	http://purl.obolibrary.org/obo/HP_0033948	Arcuate artery intima/media arteriitis		A type of arcuate artery intima/media granulomatous arteriitis characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries.
http://purl.obolibrary.org/obo/HP_0033950	Cortical radial artery intraluminal thrombi	http://purl.obolibrary.org/obo/HP_0033884	Abnormal cortical radial artery lumen morphology		Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen within the interior space of cortical radial arteries (interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033951	Cortical radial artery intraluminal organized thrombi	http://purl.obolibrary.org/obo/HP_0033950	Cortical radial artery intraluminal thrombi		Thrombi containing fibrous tissue and capillary-like vascular channels within the interior space of cortical radial arteries (interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033952	Abnormal cortical radial artery endothelium morphology	http://purl.obolibrary.org/obo/HP_0033883	Abnormal cortical radial artery morphology		Abnormal structural characteristics of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033953	Cortical radial artery endotheliosis	http://purl.obolibrary.org/obo/HP_0033952	Abnormal cortical radial artery endothelium morphology		Enlargement of endothelial cells of the cortical radial arteries (also known as the interlobular arteries) of the kidney because of cytoplasmic swelling.
http://purl.obolibrary.org/obo/HP_0033954	Cortical radial artery hypercellularity	http://purl.obolibrary.org/obo/HP_0033952	Abnormal cortical radial artery endothelium morphology		Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney.
http://purl.obolibrary.org/obo/HP_0033955	Cortical radial artery leukocyte hypercellularity	http://purl.obolibrary.org/obo/HP_0033954	Cortical radial artery hypercellularity		A type of cortical radial artery endoarterial hypercellularity due to increased numbers of white blood cells (leukocytes).
http://purl.obolibrary.org/obo/HP_0033956	Cortical radial artery lymphocyte hypercellularity	http://purl.obolibrary.org/obo/HP_0033955	Cortical radial artery leukocyte hypercellularity		A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of cortical radial arteries.
http://purl.obolibrary.org/obo/HP_0033957	Cortical radial artery neutrophil hypercellularity	http://purl.obolibrary.org/obo/HP_0033955	Cortical radial artery leukocyte hypercellularity		A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of increased numbers of neutrophils in the lumen of cortical radial arteries.
http://purl.obolibrary.org/obo/HP_0033958	Cortical radial artery foam cell hypercellularity	http://purl.obolibrary.org/obo/HP_0033955	Cortical radial artery leukocyte hypercellularity		A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often macrophages, with a vacuolated appearance in the lumen of cortical radial artery (also known as the interlobular artery) of the kidney.
http://purl.obolibrary.org/obo/HP_0033959	Cortical radial artery intima/media arteriosclerosis	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Thickening of the intima of the cortical radial artery (also known as the interlobular artery) of the kidney characterized by fibrosis and/or duplication of the elastic lamina.
http://purl.obolibrary.org/obo/HP_0033960	Cortical radial artery intimal mucoid edema	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Accumulation of edematous extracellular matrix in the intima of the cortical radial artery (also known as the interlobular artery) of the kidney. This material resembles mucus and stains pale blue on hematoxylin and eosin staining.
http://purl.obolibrary.org/obo/HP_0033961	Cortical radial artery intima/media multilamellation	http://purl.obolibrary.org/obo/HP_0033888	Abnormal cortical radial artery intima/media morphology		Myointimal hyperplasia of the inner and middle layer of the cortical radial artery (also known as the interlobular artery) of the kidney, arranged in multiple concentric layers.
http://purl.obolibrary.org/obo/HP_0033962	Cortical radial artery medial/intimal granulomatous arteriitis	http://purl.obolibrary.org/obo/HP_0033913	Cortical radial artery medial/intimal arteriitis		A type of cortical radial artery medial/intimal arteriitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries.
http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology	http://purl.obolibrary.org/obo/HP_0033854	Abnormal interlobular vein morphology		Any structural anomaly of the inner or middle layer of the interlobular veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033964	Interlobular intima/media venosclerosis	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Thickening of the intima with fibrosis and/or duplication of the elastic lamina in interlobular veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033965	Interlobular vein intimal mucoid edema	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Accumulation of edematous extracellular matrix in the intima of the interlobular vein of the kidney. This material resembles mucus and stains pale blue on hematoxylin and eosin staining.
http://purl.obolibrary.org/obo/HP_0033966	Interlobular vein intima/media amyloidosis	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular veins of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy
http://purl.obolibrary.org/obo/HP_0033967	Interlobular vein intima/media venulitis	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Inflammation of the interlobular veins of the kidney which may affect only the intima or may be transmural.
http://purl.obolibrary.org/obo/HP_0033968	Interlobular vein intima/media granulomatous venulitis	http://purl.obolibrary.org/obo/HP_0033967	Interlobular vein intima/media venulitis		A type of interlobular vein intima/media venulitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins.
http://purl.obolibrary.org/obo/HP_0033969	Interlobular vein intima/media necrosis	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Cell death (necrosis) in the inner or middle layer of the interlobular vein of the kidney.
http://purl.obolibrary.org/obo/HP_0033970	Interlobular vein intima/media liquefactive necrosis	http://purl.obolibrary.org/obo/HP_0033969	Interlobular vein intima/media necrosis		A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.
http://purl.obolibrary.org/obo/HP_0033971	Interlobular vein intima/media coagulative necrosis	http://purl.obolibrary.org/obo/HP_0033969	Interlobular vein intima/media necrosis		A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.
http://purl.obolibrary.org/obo/HP_0033972	Interlobular vein medial atrophy	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Atrophy (wasting, decreased thickness) of the medial layer pf the interlobular veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033973	Interlobular vein medial hypertrophy	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Increased thickness of middle layer of the interlobular veins of the kidney.
http://purl.obolibrary.org/obo/HP_0033974	Interlobular vein intima/media multilamellation	http://purl.obolibrary.org/obo/HP_0033963	Abnormal interlobular vein intima/media morphology		Myointimal hyperplasia of the inner and middle layer of the interlobular veins of the kidney, arranged in multiple concentric layers.
http://purl.obolibrary.org/obo/HP_0033975	Absent second fingernail	http://purl.obolibrary.org/obo/HP_0001817	Absent fingernail		Absence of the fingernail of the index (second) finger.
http://purl.obolibrary.org/obo/HP_0033976	Volar fingernail	http://purl.obolibrary.org/obo/HP_0001231	Abnormal fingernail morphology		The presence of an extra nail on the palmar (volar, ventral) surface of the finger.
http://purl.obolibrary.org/obo/HP_0033977	Talar aplasia	http://purl.obolibrary.org/obo/HP_0008365	Abnormal talus morphology		Absent talus owing to a congenital defect.
http://purl.obolibrary.org/obo/HP_0033978	Reduced beta-hexosaminidase B activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Diminished activity of the enzyme beta-hexosaminidase in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033979	Excessive dynamic airway collapse	http://purl.obolibrary.org/obo/HP_0002786	Tracheobronchomalacia		Excessive anterior displacement of the tracheal and/or bronchial membranous wall.
http://purl.obolibrary.org/obo/HP_0033980	Paroxysmal tonic upgaze	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Recurrent episodes of sustained upward deviation of the eyes and incomplete downward saccades, and normal horizontal eye movements without impairment of consciousness.
http://purl.obolibrary.org/obo/HP_0033981	Vertebral artery tortuosity	http://purl.obolibrary.org/obo/HP_0030321	Abnormal vertebral artery morphology		Abnormal tortuous (i.e., twisted) form of the vertebral arteries.
http://purl.obolibrary.org/obo/HP_0033982	Celiac artery dissection	http://purl.obolibrary.org/obo/HP_0012326	Abnormal celiac artery morphology		A separation (dissection) of the layers of the celiac artery wall.
http://purl.obolibrary.org/obo/HP_0033983	Decreased circulating apolipoprotein C-II concentration	http://purl.obolibrary.org/obo/HP_0033459	Decreased circulating apolipoprotein concentration		The concentration of apolipoprotein C-II in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033984	Increased urinary 8-oxo-7,8-dihydroguanosine level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		An elevated amount of 8-oxo-7,8-dihydroguanosine in the urine.
http://purl.obolibrary.org/obo/HP_0033985	Elongated femoral neck	http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology		Increased length of the neck of the femur.
http://purl.obolibrary.org/obo/HP_0033986	Tortuous lymphatic vessels	http://purl.obolibrary.org/obo/HP_0100766	Abnormal lymphatic vessel morphology		The presence of an increased number of twists and turns of lymphatic vessels.
http://purl.obolibrary.org/obo/HP_0033987	Phosphaturic mesenchymal tumor	http://purl.obolibrary.org/obo/HP_0031459	Soft tissue neoplasm		A rare, endocrine active tumor that causes severe renal phosphate wasting, which in turn can lead to critical osteomalacia. Phosphaturic mesenchymal tumors (PMTs) are typically small and mostly benign tumors producing fibroblast growth factor 23 (FGF-23). FGF-23 lowers the expression of sodium/phosphate cotransporters, which are the primary transport proteins responsible for phosphate reabsorption in the kidneys. The paraneoplastic overproduction of FGF-23 lowers reabsorption of phosphate and causes severe paraneoplastic renal phosphate wasting and hypophosphatemia. FGF-23 also affects vitamin D levels by lowering 25-hydroxyvitamin D 1-alpha-hydroxylase in the proximal renal tubules and by increasing the expression of vitamin D 24-hydroxylase, a mitochondrial enzyme responsible for inactivating vitamin D metabolites.
http://purl.obolibrary.org/obo/HP_4000061	Pancreatic alpha-cell hyperplasia	http://purl.obolibrary.org/obo/HP_0004510	Pancreatic islet-cell hyperplasia		A diffuse and specific increase in the number of alpha-cells.
http://purl.obolibrary.org/obo/HP_5000000	Anti-AK5 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-adenylate kinase 5 (AK5).
http://purl.obolibrary.org/obo/HP_5000001	Anti-AMPAR antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR).
http://purl.obolibrary.org/obo/HP_5000002	Anti-Amphiphysin antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Amphiphysin.
http://purl.obolibrary.org/obo/HP_5000003	Anti-ARHGAP26 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Rho GTPase-activating protein 26 (ARHGAP26).
http://purl.obolibrary.org/obo/HP_5000004	Anti-CARP VIII antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Carbonic anhydrase-related protein VIII (CARPVIII).
http://purl.obolibrary.org/obo/HP_5000005	Anti-CASPR2	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against contactin-associated protein-like 2 (CASPR2).
http://purl.obolibrary.org/obo/HP_5000006	Anti-CV2/CRMP5 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CV2/CRMP5. Anti-CV2/CRMP5 autoantibody is the most commonly detected anti-neuronal autoantibody. Patients with typical paraneoplastic chorea show fully developed chorea in the course of weeks to months with acute inflammation in the striatum.
http://purl.obolibrary.org/obo/HP_5000007	Anti-DPPX antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dipeptidyl-peptidase-like protein 6 (DPPX).
http://purl.obolibrary.org/obo/HP_5000008	Anti-FGFR3 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against FGFR3.
http://purl.obolibrary.org/obo/HP_5000009	Anti-GABA(A)R antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid A receptor, i.e., GABA(A)R.
http://purl.obolibrary.org/obo/HP_5000010	Anti-GABA(B)R antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid B receptor, i.e., GABA(B)R.
http://purl.obolibrary.org/obo/HP_5000011	Anti-GAD65 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamic acid decarboxylase 65 (GAD65).
http://purl.obolibrary.org/obo/HP_5000012	Anti-Gephyrin antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Gephyrin.
http://purl.obolibrary.org/obo/HP_5000013	Anti-GFAP antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glial fibrillary acidic protein (GFAP).
http://purl.obolibrary.org/obo/HP_5000014	Anti-GlyR antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Glycine receptor (GlyR).
http://purl.obolibrary.org/obo/HP_5000015	Anti-Homer-3 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Homer-3.
http://purl.obolibrary.org/obo/HP_5000016	Anti-Hu antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Hu.
http://purl.obolibrary.org/obo/HP_5000017	Anti-Iglon5 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against immunoglobulin-like cell adhesion molecule 5 (IgLON5).
http://purl.obolibrary.org/obo/HP_5000018	Anti-ITPR1 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against inositol 1,4,5-trisphosphate receptor 1 (ITPR1).
http://purl.obolibrary.org/obo/HP_5000019	Anti-Kelch like protein 11 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against kelch-like protein 11 (KLHL11).
http://purl.obolibrary.org/obo/HP_5000020	Anti-LGI1 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against leucine-rich glioma-inactivated 1 (LGI1).
http://purl.obolibrary.org/obo/HP_5000021	Anti-Ma antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma.
http://purl.obolibrary.org/obo/HP_5000022	Anti-Ma2 antibody positivity	http://purl.obolibrary.org/obo/HP_5000021	Anti-Ma antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma2.
http://purl.obolibrary.org/obo/HP_5000023	Anti-Ma1 antibody positivity	http://purl.obolibrary.org/obo/HP_5000021	Anti-Ma antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma1.
http://purl.obolibrary.org/obo/HP_5000024	Anti-mGluR1 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 1 (mGluR1).
http://purl.obolibrary.org/obo/HP_5000025	Anti-mGluR5 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 5 (mGluR5).
http://purl.obolibrary.org/obo/HP_5000026	Anti-neurexin-3alpha antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neurexin-3alpha.
http://purl.obolibrary.org/obo/HP_5000027	Anti-P/Q-type VGCC antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against P/Q-type voltage-gated calcium channels (VGCCs).
http://purl.obolibrary.org/obo/HP_5000028	Anti-MAP1B antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against microtubule-associated protein 1B (MAP1B).
http://purl.obolibrary.org/obo/HP_5000029	Anti-PKCgamma antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against protein kinase Cgamma.
http://purl.obolibrary.org/obo/HP_5000030	Anti-Ri antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ri, an antineuronal antibody.
http://purl.obolibrary.org/obo/HP_5000031	Anti-Septin-5 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Septin-5.
http://purl.obolibrary.org/obo/HP_5000032	Anti-SEZ6L2 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against seizure-related 6 homolog like 2 (SEZ6L2).
http://purl.obolibrary.org/obo/HP_5000033	Anti-SOX1 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SOX1. Anti-SOX1 antibodies, also known as antiglial nuclear antibody (AGNA), are specifically found in paraneoplastic neurological disorders. Since SOX1 is expressed in neuronal precursor cells in the developing central nervous system, it has been used as an early marker of neural stem cells.
http://purl.obolibrary.org/obo/HP_5000034	Anti-Tr/DNER antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Tr/DNER. Anti-Tr antibodies are directed against cerebellar Purkinje cells (termed anti-Tr or PCA-Tr). Anti-Tr autoantibodies are frequently associated with Hodgkin lymphoma (HL). Anti-Tr antibodies are defined by a specific staining pattern in cerebellar tissue that is characterized by punctate immunoreactivity in both the dendritic tree and soma of Purkinje cells but not in their axons. This characteristic pattern is indicative of the presence of anti-Tr antibodies. The Delta/Notch-like epidermal growth factor-related receptor (DNER) was identified as the target antigen of anti-Tr.
http://purl.obolibrary.org/obo/HP_5000035	Anti-TRIM46 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the axon initial segment protein tripartite motif 46 (TRIM46).
http://purl.obolibrary.org/obo/HP_5000036	Anti-TRIM9/TRIM67 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against TRIM9/TRIM67.
http://purl.obolibrary.org/obo/HP_5000037	Anti-Yo antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Yo.
http://purl.obolibrary.org/obo/HP_5000038	Anti-titin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against titin.
http://purl.obolibrary.org/obo/HP_5000039	Anti-Zic4 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Zic family member 4 (ZIC4).
http://purl.obolibrary.org/obo/HP_5000042	Anti-Sj/ITPR1 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Sj/inositol 1,4,5-trisphosphate receptor.
http://purl.obolibrary.org/obo/HP_5000043	Anti-D2 R antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dopamine-2 receptor.
http://purl.obolibrary.org/obo/HP_5000044	Anti-GluK2 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamate kainate receptor subunit 2 (GluK2).
http://purl.obolibrary.org/obo/HP_5000046	Anti-Lrp4 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against low-density lipoprotein receptor (Lrp4).
http://purl.obolibrary.org/obo/HP_5000047	Anti-ryanodine receptor antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ryanodine receptor.
http://purl.obolibrary.org/obo/HP_5000048	Anti-Kv1.4 antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the voltage-gated potassium channel Kv1.4.
http://purl.obolibrary.org/obo/CHEBI_156068	alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose(1-)	http://purl.obolibrary.org/obo/CHEBI_33721	carbohydrate acid anion		The conjugate base of α-<em>N</em>-acetylneuraminosyl-(2→3)-β-<small>D</small>-galactosyl-(1→4)-<small>D</small>-glucose arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/HP_0034033	Peripheral cyanosis	http://purl.obolibrary.org/obo/HP_0000961	Cyanosis		Bluish discoloration of the distal extremities in the absence of cold temperature or stress. Peripheral cyanosis can involve hands, fingertips, or toes, and sometimes circumoral and periorbital areas. Mucous membranes are generally not involved.
http://purl.obolibrary.org/obo/HP_0033993	Viral encephalitis	http://purl.obolibrary.org/obo/HP_0032169	Severe infection		An inflammation of brain parenchyma due to infection with a virus. Viral encephalitis can occur as a rare complication of common infections (eg, herpes virus infections) or can occur as a characteristic presentation of rare viruses (eg, rabies virus infection). Encephalitis may be the only neurologic manifestation of infection, or may occur in association with meningitis, myelitis, radiculitis, or neuritis. Viral encephalitis is associated with neurological dysfunction.
http://purl.obolibrary.org/obo/HP_0033988	Amygdala microinfarct	http://purl.obolibrary.org/obo/HP_0033668	Abnormal amygdala morphology		An infarct located in the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe that can only be observed microscopically.
http://purl.obolibrary.org/obo/HP_0033989	Hippocampal microinfarct	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		An infarct located in the structure of the cerebrum involved with memory storage and spatial navigation that can only be observed microscopically.
http://purl.obolibrary.org/obo/HP_0033990	Cartilaginous tracheobronchomalacia	http://purl.obolibrary.org/obo/HP_0002786	Tracheobronchomalacia		Softening of the tracheal and/or bronchial cartilage resulting in segmental tracheal and/or bronchial weakness.
http://purl.obolibrary.org/obo/HP_0033991	Vasa previa	http://purl.obolibrary.org/obo/HP_0011418	Abnormal insertion of umbilical cord		Vasa previa occurs when the membranes that contain the umbilical cord traverse the membranes overlying the internal os of the cervix. There is a high risk of fetal mortality if not identified perinatally.
http://purl.obolibrary.org/obo/HP_0033992	Chronotropic incompetence	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Inability of the heart to increase its rate commensurate with increased activity or demand.
http://purl.obolibrary.org/obo/HP_0033994	Dependency on parenteral nutrition	http://purl.obolibrary.org/obo/HP_0011968	Feeding difficulties		Inability to ingest sufficient quantities of nutrition by mouth or by tube-feeding with the corresponding requirement for intravenous administration of nutrition.
http://purl.obolibrary.org/obo/HP_0033995	Microvillus inclusions	http://purl.obolibrary.org/obo/HP_0011472	Abnormal small intestinal villus morphology		The presence of vacuoles bearing centripetal microvilli in small gut villus enterocytes.
http://purl.obolibrary.org/obo/HP_0033996	Microvillar PAS-positive secretory granules	http://purl.obolibrary.org/obo/HP_0011472	Abnormal small intestinal villus morphology		The presenceaccumulationof periodic acid-Schiff (PAS) granules in the subapical region of small intenstinal microvilli, appearing as different kinds of vesicular/tubular structures.
http://purl.obolibrary.org/obo/HP_0033997	Perinuclear cardiomyocyte vacuolization	http://purl.obolibrary.org/obo/HP_0031331	Abnormal cardiomyocyte morphology		Formation of vacuoles, i.e., membrane-bound organelles, in the portion of the cytoplasm near the nucleus within myocytes of the heart.
http://purl.obolibrary.org/obo/HP_0033998	Single-lobed right lung	http://purl.obolibrary.org/obo/HP_0002101	Abnormal lung lobation		A developmental defect of pulmonary lobation characterized by the presence of only one lobe of the right lung, which normally has three lobes.
http://purl.obolibrary.org/obo/HP_0033999	Bronchial hemorrhage	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Bronchial hemorrhage is a focal bleeding located in the bronchial system. It can be diagnosed by tracheobronchoscopy.
http://purl.obolibrary.org/obo/HP_0034000	Tracheal hemorrhage	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		Tracheal hemorrhage is a focal bleeding within the trachea. It be diagnosed by tracheobronchoscopy.
http://purl.obolibrary.org/obo/HP_0034001	Anti-Complement factor H antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against complement factor H.
http://purl.obolibrary.org/obo/HP_0034002	Anti-phospholipase A2 receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the phospholipase A2 receptor.
http://purl.obolibrary.org/obo/HP_0034003	Broad medial eyebrow	http://purl.obolibrary.org/obo/HP_0011229	Broad eyebrow		Regional increase in the width (height) of the middle portion of the eyebrow.
http://purl.obolibrary.org/obo/HP_0034004	Parosmia	http://purl.obolibrary.org/obo/HP_0004408	Abnormality of the sense of smell		Misperception of existing odor, that is, distorted or altered olfactory perception in the presence of known stimuli.
http://purl.obolibrary.org/obo/HP_0034005	Decreased dendritic spine number	http://purl.obolibrary.org/obo/HP_0500032	Abnormal neuron branching		An abnormal reduction in the amount of spines on a given dendrite.
http://purl.obolibrary.org/obo/HP_0034006	Decreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		A decreased amount of the urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) as compared to hydroxylysyl-pyridinoline (HP, or pyridinoline PYD). Both are established biochemical markers of osteoclastic bone resorption and collagen degradation.
http://purl.obolibrary.org/obo/HP_0034007	Posterior atrophy of corpus callosum	http://purl.obolibrary.org/obo/HP_0033725	Thin corpus callosum		The presence of atrophy (wasting) of the posterior portion of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0034008	Opto-chiasmatic atrophy	http://purl.obolibrary.org/obo/HP_0025163	Abnormal optic chiasm morphology		Wasting (atrophy) of the optic chiasm.
http://purl.obolibrary.org/obo/HP_0034009	Pelvic lipomatosis	http://purl.obolibrary.org/obo/HP_0001012	Multiple lipomas		Overgrowth of fat in the perivesical and perirectal area.
http://purl.obolibrary.org/obo/HP_0034010	Increased megakaryocyte colony forming unit count	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		Increased numbers of megakryocyte precursors (megakaryocyte colony forming units) in the bone marrow.
http://purl.obolibrary.org/obo/HP_0034011	Reduced progressive sperm motility	http://purl.obolibrary.org/obo/HP_0012206	Abnormal sperm motility		A reduced proportion of sperm that move in a straight line or large circles; alternatively, an increased proportion of sperm that move in tight circles or in some other non-linear fashion.
http://purl.obolibrary.org/obo/HP_0034012	Palmoplantar hypohidrosis	http://purl.obolibrary.org/obo/HP_0000966	Hypohidrosis		Decreased sweating on the palms and soles.
http://purl.obolibrary.org/obo/HP_0034013	Curvilinear pericallosal lipoma	http://purl.obolibrary.org/obo/HP_0006931	Pericallosal lipoma		A type of pericallosal lipoma that is thin and curves around the posterior end of the splenium of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0034014	Tubulonodular pericallosal lipoma	http://purl.obolibrary.org/obo/HP_0006931	Pericallosal lipoma		A type of pericallosal lipoma with a rounded or lobular appearance and a diameter that is usually above 2 cm. They are anteriorly situated and are associated with extensive callosal and often fronto-facial anomalies. A tubulonodular pericallosal lipoma can extend into the choroid plexus or lateral ventricles.
http://purl.obolibrary.org/obo/HP_0034015	Cavitating pulmonary nodule	http://purl.obolibrary.org/obo/HP_0033655	Pulmonary cavity		Thick-walled abnormal gas-filled interstitial nodule within a lung.
http://purl.obolibrary.org/obo/HP_0034016	Anti-HLA antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen (HLA).
http://purl.obolibrary.org/obo/HP_0034017	Anti-class I HLA antibody positivity	http://purl.obolibrary.org/obo/HP_0034016	Anti-HLA antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a class I human leukocyte antigen (HLA). Class I HLA corresponds to MHC class I (A, B, and C).
http://purl.obolibrary.org/obo/HP_0034018	Anti-class II HLA antibody positivity	http://purl.obolibrary.org/obo/HP_0034016	Anti-HLA antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a class II human leukocyte antigen (HLA). Class I HLA corresponds to MHC class II (DP, DM, DO, DQ, and DR).
http://purl.obolibrary.org/obo/HP_0034019	Anti-HLA-A antibody positivity	http://purl.obolibrary.org/obo/HP_0034017	Anti-class I HLA antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen-A (HLA-A).
http://purl.obolibrary.org/obo/HP_0034020	Anti-HLA-A IgG1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034019	Anti-HLA-A antibody positivity		The presence of IgG1 autoantibodies in the blood circulation that react against a human leukocyte antigen-A (HLA-A).
http://purl.obolibrary.org/obo/HP_0034021	Anti-HLA-A IgG3 antibody positivity	http://purl.obolibrary.org/obo/HP_0034019	Anti-HLA-A antibody positivity		The presence of IgG3 autoantibodies in the blood circulation that react against a human leukocyte antigen-A (HLA-A).
http://purl.obolibrary.org/obo/HP_0034022	Anti-HLA-B antibody positivity	http://purl.obolibrary.org/obo/HP_0034017	Anti-class I HLA antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen-B (HLA-B).
http://purl.obolibrary.org/obo/HP_0034023	Anti-HLA-B IgG1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034022	Anti-HLA-B antibody positivity		The presence of IgG1 autoantibodies in the blood circulation that react against a human leukocyte antigen-B (HLA-B).
http://purl.obolibrary.org/obo/HP_0034024	Anti-HLA-B IgG3 antibody positivity	http://purl.obolibrary.org/obo/HP_0034022	Anti-HLA-B antibody positivity		The presence of IgG3 autoantibodies in the blood circulation that react against a human leukocyte antigen-B (HLA-B).
http://purl.obolibrary.org/obo/HP_0034025	Abnormal circulating GABA concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Any deviation from the normal concentration of gamma-aminobutyric acid (GABA) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034026	Elevated circulating saccharopine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An increased concentration of saccharopine in the blood circulation. L-saccharopine is the N(6)-(1,3-dicarboxypropan-1-yl) derivative of L-lysine.
http://purl.obolibrary.org/obo/HP_0034029	Hepatic foam cells	http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology		The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, in the liver.
http://purl.obolibrary.org/obo/HP_0034030	Lip cyanosis	http://purl.obolibrary.org/obo/HP_0034031	Facial cyanosis		Bluish discoloration of the lips.
http://purl.obolibrary.org/obo/HP_0034031	Facial cyanosis	http://purl.obolibrary.org/obo/HP_0034033	Peripheral cyanosis		Bluish discoloration of one or more regions of the face.
http://purl.obolibrary.org/obo/HP_0034032	Central cyanosis	http://purl.obolibrary.org/obo/HP_0000961	Cyanosis		Generalized bluish discoloration of the body and the visible mucous membranes, which occurs due to inadequate oxygenation secondary to conditions that lead to an increase in deoxygenated hemoglobin or presence of abnormal hemoglobin.
http://purl.obolibrary.org/obo/HP_0034034	Differential cyanosis	http://purl.obolibrary.org/obo/HP_0000961	Cyanosis		Differential degree of bluish discoloration between the upper and lower extremities.
http://purl.obolibrary.org/obo/HP_0034035	Pharyngeal exudate	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		Fluid exuded from the posterior wall of the pharynx.
http://purl.obolibrary.org/obo/HP_0034036	Pseudo-chilblains on toes	http://purl.obolibrary.org/obo/HP_0033696	Pseudo-chilblain		Inflammatory chilblain-like nodules on the feet and/or toes.
http://purl.obolibrary.org/obo/HP_0034037	Pseudo-chilblains on fingers	http://purl.obolibrary.org/obo/HP_0033696	Pseudo-chilblain		Inflammatory chilblain-like nodules on the hands and/or fingers.
http://purl.obolibrary.org/obo/HP_0034038	Silent hypoxemia	http://purl.obolibrary.org/obo/HP_0012418	Hypoxemia		Abnormally low blood oxygen level without the presence of dyspnea.
http://purl.obolibrary.org/obo/HP_0034039	Ventricular couplet	http://purl.obolibrary.org/obo/HP_0006682	Premature ventricular contraction		Two consecutive premature ventricular contractions (PVCs) with no intervening normal beats.
http://purl.obolibrary.org/obo/HP_0034040	Bidirectional ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004756	Ventricular tachycardia		Bidirectional ventricular tachycardia (BDVT) is a regular ventricular tachyarrhythmia (VT) with two different QRS morphologies alternating at a rate typically between 140 and 180 bpm.
http://purl.obolibrary.org/obo/HP_0034042	Dorsal hirsutism	http://purl.obolibrary.org/obo/HP_0009889	Localized hirsutism		Abnormally increased hair growth in the lskin of the back.
http://purl.obolibrary.org/obo/HP_0041094	Complete tracheal ring	http://purl.obolibrary.org/obo/HP_0004468	Anomalous tracheal cartilage		Continuous or nearly continuous configuration of the cartilaginous tracheal ring.
http://purl.obolibrary.org/obo/HP_4000062	3-4 metacarpal synostosis	http://purl.obolibrary.org/obo/HP_0009707	Synostosis involving the 4th metacarpal		A congenital hand malformation characterized by the coalescence of the coalescence of third and fourth metacarpals (i.e., those corresponding to the middle and ring fingers).
http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier	http://purl.obolibrary.org/obo/HP_0000005	Mode of inheritance		The terms in this hierarchy can be used to specify the context in which inheritance of a disease is typically observed.
http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance	http://purl.obolibrary.org/obo/HP_0000005	Mode of inheritance		A mode of inheritance of diseases whose pathophysiology can be traced back to deleterious variants in a single gene. The inheritance patterns of these single-gene (monogenic) diseases are often referred to as Mendelian in honor of Gregor Mendel.
http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity	http://purl.obolibrary.org/obo/HP_0001257	Spasticity		A type of spasticity that affects one or more limbs (arms or legs).
http://purl.obolibrary.org/obo/HP_0034376	Atrioventricular valve regurgitation	http://purl.obolibrary.org/obo/HP_0031650	Abnormal atrioventricular valve physiology		Regurgitation of a heart valve that controls blood flow from a an atrium to a ventricle, including mitral, tricuspid, or, rarely, single atrioventicular valve.
http://purl.obolibrary.org/obo/HP_0034392	Joint contracture	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		A limitation in the passive range of motion of a joint resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin. A contracture prevents movement of the associated body part.
http://purl.obolibrary.org/obo/CL_4033017	bronchiolar smooth muscle cell	http://purl.obolibrary.org/obo/CL_0019019	tracheobronchial smooth muscle cell		A smooth muscle cell that is part of a bronchiole.
http://purl.obolibrary.org/obo/HP_5200059	Sensory hyposensitivity unexplained by sensory deficit	http://purl.obolibrary.org/obo/HP_5200046	Sensory behavioral abnormality		Increased tolerance to sensory stimuli due to diminished sensory ability.
http://purl.obolibrary.org/obo/HP_5200061	Tactile hypersensitivity	http://purl.obolibrary.org/obo/HP_5200058	Sensory hypersensitivity		A decreased tolerance to physical touch.
http://purl.obolibrary.org/obo/HP_5200062	Auditory sensory seeking	http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking		Pursuit of specific sounds or noises that is abnormal in intensity and/or frequency.
http://purl.obolibrary.org/obo/HP_5200063	Gustatory sensory seeking	http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking		Pursuit of a particular taste that is abnormal in intensity and/or frequency.
http://purl.obolibrary.org/obo/HP_5200064	Olfactory sensory seeking	http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking		Pursuit of specific scents, smells, or fragrances that is abnormal in intensity and/or frequency.
http://purl.obolibrary.org/obo/HP_5200066	Vestibular sensory seeking	http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking		Pursuit of vestibular stimulation that is abnormal in intensity and/or frequency.
http://purl.obolibrary.org/obo/HP_5200067	Visual sensory seeking	http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking		Pursuit visual stimulation by looking at specific sights, images, and/or colors that is abnormal in intensity and/or frequency.
http://purl.obolibrary.org/obo/HP_5200068	Socially inappropriate questioning	http://purl.obolibrary.org/obo/HP_5200029	Social disinhibition		A tendency to ask questions that are overly personal or otherwise inappropriate in the social situation in which they are asked.
http://purl.obolibrary.org/obo/HP_5200069	Spinning	http://purl.obolibrary.org/obo/HP_5200019	Stereotypic whole-body movements		An excessive frequency of spinning one's body.
http://purl.obolibrary.org/obo/HP_5200071	Delayed Echolalia	http://purl.obolibrary.org/obo/HP_0010529	Echolalia		Repetition of borrowed words or phrases outside of the context in which they were originally heard. E.g., scripting from TV shows or movies.
http://purl.obolibrary.org/obo/HP_5200072	Immediate Echolalia	http://purl.obolibrary.org/obo/HP_0010529	Echolalia		Immediate repetition of another person's speech.
http://purl.obolibrary.org/obo/HP_5200073	Excessive cleaning	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		Excessive cleaning of surfaces, living space, or environment that is excessive for the situational context.
http://purl.obolibrary.org/obo/HP_5201000	Incomplete unilateral cleft lip	http://purl.obolibrary.org/obo/HP_0100333	Unilateral cleft lip		Unilateral cleft lip cleft that starts from the bottom of the upper lip but does not reach the nasal cavity.
http://purl.obolibrary.org/obo/HP_5201001	Complete unilateral cleft lip	http://purl.obolibrary.org/obo/HP_5201009	Complete cleft of the upper lip		Unilateral cleft lip cleft that starts from the bottom of the upper lip and reaches the nasal cavity.
http://purl.obolibrary.org/obo/HP_5201002	Microform unilateral cleft lip	http://purl.obolibrary.org/obo/HP_5201010	Microform cleft of the upper lip		Notch, groove, or scar of the upper lip without noticeable rupture of the lip. Microforms are sometimes associated with disruption of the continuity of the orbicularis oris muscle.
http://purl.obolibrary.org/obo/HP_5201003	Complete cleft hard palate	http://purl.obolibrary.org/obo/HP_0410005	Cleft hard palate		Cleft hard palate in which the cleft goes through the entire length of the hard palate, ie. from the incisor foramen to the anterior border of the soft palate.
http://purl.obolibrary.org/obo/HP_5201004	Incomplete cleft hard palate	http://purl.obolibrary.org/obo/HP_0410005	Cleft hard palate		Cleft hard palate in which the cleft does not go through the entire length of the hard palate, ie. the cleft does not go from the incisor foramen to the anterior border of the soft palate.
http://purl.obolibrary.org/obo/HP_5201005	Complete cleft soft palate	http://purl.obolibrary.org/obo/HP_0000185	Cleft soft palate		Cleft soft palate in which the cleft goes through the entire length of the soft palate, i.e. from the posterior border of the hard palate until the uvula.
http://purl.obolibrary.org/obo/HP_5201006	Incomplete cleft soft palate	http://purl.obolibrary.org/obo/HP_0000185	Cleft soft palate		Cleft soft palate in which the cleft does not go through the entire length of the soft palate, i.e. the cleft does not go from the posterior border of the hard palate until the uvula.
http://purl.obolibrary.org/obo/HP_5201007	Incomplete cleft maxillary alveolar ridge	http://purl.obolibrary.org/obo/HP_0010289	Cleft maxillary alveolar ridge		Cleft maxillary alveolar ridge in which the cleft does not go through the entire length of the maxillary alveolar ridge.
http://purl.obolibrary.org/obo/HP_5201008	Complete cleft maxillary alveolar ridge	http://purl.obolibrary.org/obo/HP_0010289	Cleft maxillary alveolar ridge		Cleft maxillary alveolar ridge in which the cleft goes through the entire length of the maxillary alveolar ridge.
http://purl.obolibrary.org/obo/HP_0034902	Abnormal circulating calcitonin concentration	http://purl.obolibrary.org/obo/HP_0100530	Abnormal circulating calcium-phosphate regulating hormone concentration		Concentration of calcitonin, a 32-amino acid polypeptide hormone that is produced primarily by the parafollicular cells of the thyroid, in the blood circulation outside of normal limits.
http://purl.obolibrary.org/obo/HP_0034980	Synkinesis	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Unintentional movement in one area of the body produced during intentional movement of another area of the body.
http://purl.obolibrary.org/obo/UBERON_8600034	jejunum lamina propria	http://purl.obolibrary.org/obo/UBERON_0001238	lamina propria of small intestine		A lamina propria that is part of a jejunum.
http://purl.obolibrary.org/obo/UBERON_8600035	ileum lamina propria	http://purl.obolibrary.org/obo/UBERON_0001238	lamina propria of small intestine		A lamina propria that is part of an ileum.
http://purl.obolibrary.org/obo/UBERON_8600042	endometrial lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A lymphatic vessel that is part of an endometrium.
http://purl.obolibrary.org/obo/CHEBI_131604	Mycoplasma genitalium metabolite	http://purl.obolibrary.org/obo/CHEBI_76969	bacterial metabolite		Any bacterial metabolite produced during a metabolic reaction in <em>Mycoplasma genitalium</em>.
http://purl.obolibrary.org/obo/CHEBI_15705	L-alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		Any α-amino acid having <small>L</small>-configuration at the α-carbon.
http://purl.obolibrary.org/obo/CHEBI_16670	peptide	http://purl.obolibrary.org/obo/CHEBI_37622	carboxamide		Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from α-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
http://purl.obolibrary.org/obo/CHEBI_16708	adenine	http://purl.obolibrary.org/obo/CHEBI_20706	6-aminopurines		The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.
http://purl.obolibrary.org/obo/CHEBI_17087	ketone	http://purl.obolibrary.org/obo/CHEBI_36586	carbonyl compound		A compound in which a carbonyl group is bonded to two carbon atoms: R<small><sub>2</sub></small>C=O (neither R may be H).
http://purl.obolibrary.org/obo/CHEBI_17120	hexanoate	http://purl.obolibrary.org/obo/CHEBI_78116	fatty acid anion 6:0		A short-chain fatty acid anion that is the conjugate base of hexanoic acid (also known as caproic acid).
http://purl.obolibrary.org/obo/CHEBI_17151	xylitol	http://purl.obolibrary.org/obo/CHEBI_25899	pentitol		A pentitol (five-carbon sugar alcohol) having <i>meso</i>-configuration, being derived from xylose by reduction of the carbonyl group.
http://purl.obolibrary.org/obo/CHEBI_17568	uracil	http://purl.obolibrary.org/obo/CHEBI_38337	pyrimidone		A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription.
http://purl.obolibrary.org/obo/CHEBI_17859	glutaric acid	http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid		An α,ω-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_20706	6-aminopurines	http://purl.obolibrary.org/obo/CHEBI_22527	aminopurine		Any compound having 6-aminopurine (adenine) as part of its structure.
http://purl.obolibrary.org/obo/CHEBI_21644	N-acyl-L-amino acid	http://purl.obolibrary.org/obo/CHEBI_51569	N-acyl-amino acid		Any <em>N</em>-acylamino acid having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_21731	N-glycosyl compound	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond.
http://purl.obolibrary.org/obo/CHEBI_22160	acetamides	http://purl.obolibrary.org/obo/CHEBI_37622	carboxamide		Compounds with the general formula RNHC(=O)CH<small><sub>3</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_22315	alkaloid	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is  exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
http://purl.obolibrary.org/obo/CHEBI_22586	antioxidant	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
http://purl.obolibrary.org/obo/CHEBI_22587	antiviral agent	http://purl.obolibrary.org/obo/CHEBI_33281	antimicrobial agent		A substance that destroys or inhibits replication of viruses.
http://purl.obolibrary.org/obo/CHEBI_22712	benzenes	http://purl.obolibrary.org/obo/CHEBI_33836	benzenoid aromatic compound		Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
http://purl.obolibrary.org/obo/CHEBI_22723	benzoic acids	http://purl.obolibrary.org/obo/CHEBI_33859	aromatic carboxylic acid		Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group.
http://purl.obolibrary.org/obo/CHEBI_24373	glycine derivative	http://purl.obolibrary.org/obo/CHEBI_83811	proteinogenic amino acid derivative		A proteinogenic amino acid derivative resulting from reaction of glycine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_24780	imidazoles	http://purl.obolibrary.org/obo/CHEBI_23677	diazole		A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.
http://purl.obolibrary.org/obo/CHEBI_24828	indoles	http://purl.obolibrary.org/obo/CHEBI_22728	benzopyrrole		Any compound containing an indole skeleton.
http://purl.obolibrary.org/obo/CHEBI_24995	lactam	http://purl.obolibrary.org/obo/CHEBI_37622	carboxamide		Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
http://purl.obolibrary.org/obo/CHEBI_25212	metabolite	http://purl.obolibrary.org/obo/CHEBI_52206	biochemical role		Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
http://purl.obolibrary.org/obo/CHEBI_25235	monomethoxybenzene	http://purl.obolibrary.org/obo/CHEBI_51683	methoxybenzenes		Compounds containing a benzene skeleton substituted with one methoxy group.
http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		An oxoacid containing a single carboxy group.
http://purl.obolibrary.org/obo/CHEBI_25697	organic cation	http://purl.obolibrary.org/obo/CHEBI_36916	cation		Any organic ion with a net positive charge.
http://purl.obolibrary.org/obo/CHEBI_25985	phenylalanine derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine  by a heteroatom. The definition normally excludes peptides containing phenylalanine  residues.
http://purl.obolibrary.org/obo/CHEBI_26273	proline derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of proline by a heteroatom. The definition normally excludes peptides containing proline residues.
http://purl.obolibrary.org/obo/CHEBI_26421	pyridines	http://purl.obolibrary.org/obo/CHEBI_25693	organic heteromonocyclic compound		Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
http://purl.obolibrary.org/obo/CHEBI_26658	sesquiterpenoid	http://purl.obolibrary.org/obo/CHEBI_26873	terpenoid		Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
http://purl.obolibrary.org/obo/CHEBI_26878	tertiary alcohol	http://purl.obolibrary.org/obo/CHEBI_30879	alcohol		A tertiary alcohol is a compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
http://purl.obolibrary.org/obo/CHEBI_27093	tricarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		An oxoacid containing three carboxy groups.
http://purl.obolibrary.org/obo/CHEBI_27162	tryptamines	http://purl.obolibrary.org/obo/CHEBI_24828	indoles		Tryptamine and its substitution derivatives.
http://purl.obolibrary.org/obo/CHEBI_28384	vitamin K	http://purl.obolibrary.org/obo/CHEBI_132142	1,4-naphthoquinones		Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.
http://purl.obolibrary.org/obo/CHEBI_28425	alpha-carotene	http://purl.obolibrary.org/obo/CHEBI_139120	carotenoid beta-end derivative		A cyclic carotene with a β- and an ε-ring at opposite ends respectively.
http://purl.obolibrary.org/obo/CHEBI_28940	calciol	http://purl.obolibrary.org/obo/CHEBI_36853	hydroxy seco-steroid		A hydroxy seco-steroid that is (5<i>Z</i>,7<i>E</i>)-9,10-secocholesta-5,7,10(19)-triene in which the <em>pro</em>-<i>S</i> hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D<small><sub>3</sub></small>, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D<small><sub>3</sub></small>), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D<small><sub>3</sub></small>), the active hormone.
http://purl.obolibrary.org/obo/CHEBI_29347	monocarboxylic acid amide	http://purl.obolibrary.org/obo/CHEBI_37622	carboxamide		A carboxamide derived from a monocarboxylic acid.
http://purl.obolibrary.org/obo/CHEBI_32877	primary amine	http://purl.obolibrary.org/obo/CHEBI_50994	primary amino compound		A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group.
http://purl.obolibrary.org/obo/CHEBI_33229	vitamin (role)	http://purl.obolibrary.org/obo/CHEBI_27027	micronutrient		A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term "vitamines" (from <em>vita</em> + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines.
http://purl.obolibrary.org/obo/CHEBI_33281	antimicrobial agent	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
http://purl.obolibrary.org/obo/CHEBI_33282	antibacterial agent	http://purl.obolibrary.org/obo/CHEBI_33281	antimicrobial agent		A substance (or active part thereof) that kills or slows the growth of bacteria.
http://purl.obolibrary.org/obo/CHEBI_33308	carboxylic ester	http://purl.obolibrary.org/obo/CHEBI_35701	ester		An ester of a carboxylic acid, R<small><sup>1</small></sup>C(=O)OR<small><sup>2</small></sup>, where R<small><sup>1</small></sup> = H or organyl and R<small><sup>2</small></sup> = organyl.
http://purl.obolibrary.org/obo/CHEBI_33551	organosulfonic acid	http://purl.obolibrary.org/obo/CHEBI_64709	organic acid		An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon.
http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		An amino-acid anion obtained by deprotonation of any α-amino acid.
http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35605	carbon oxoacid		A carbon oxoacid acid carrying at least one ‒C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_33709	amino acid		An amino acid in which the amino group is located on the carbon atom at the position α to the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_33706	beta-amino acid	http://purl.obolibrary.org/obo/CHEBI_83820	non-proteinogenic amino acid		A non-proteinogenic amino acid in which the amino group is located on the carbon atom at the position β to the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_33833	heteroarene	http://purl.obolibrary.org/obo/CHEBI_33659	organic aromatic compound		A heterocyclic compound formally derived from an arene by replacement of one or more methine (‒C=) and/or vinylene (‒CH=CH‒) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous π-electron system characteristic of aromatic systems and a number of out-of-plane π-electrons corresponding to the Hückel rule (4<em>n</em>+2).
http://purl.obolibrary.org/obo/CHEBI_33853	phenols	http://purl.obolibrary.org/obo/CHEBI_33659	organic aromatic compound		Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
http://purl.obolibrary.org/obo/CHEBI_33859	aromatic carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.
http://purl.obolibrary.org/obo/CHEBI_35189	sesquiterpene	http://purl.obolibrary.org/obo/CHEBI_35186	terpene		A C<small><sub>15</sub></small> terpene.
http://purl.obolibrary.org/obo/CHEBI_35221	antimetabolite	http://purl.obolibrary.org/obo/CHEBI_52206	biochemical role		A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative	http://purl.obolibrary.org/obo/CHEBI_33702	polyatomic cation		A derivative of ammonium, NH<small><sub>4</sub></small><small><sup>+</small></sup>, in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).
http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound	http://purl.obolibrary.org/obo/CHEBI_51143	nitrogen molecular entity		Any heteroorganic entity containing at least one carbon-nitrogen bond.
http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids.
http://purl.obolibrary.org/obo/CHEBI_35441	antiinfective agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A substance used in the prophylaxis or therapy of infectious diseases.
http://purl.obolibrary.org/obo/CHEBI_35470	central nervous system drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
http://purl.obolibrary.org/obo/CHEBI_35471	psychotropic drug	http://purl.obolibrary.org/obo/CHEBI_35470	central nervous system drug		A loosely defined grouping of drugs that have effects on psychological function.
http://purl.obolibrary.org/obo/CHEBI_35472	anti-inflammatory drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A substance that reduces or suppresses inflammation.
http://purl.obolibrary.org/obo/CHEBI_35480	analgesic	http://purl.obolibrary.org/obo/CHEBI_52210	pharmacological role		An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.
http://purl.obolibrary.org/obo/CHEBI_35488	central nervous system depressant	http://purl.obolibrary.org/obo/CHEBI_35470	central nervous system drug		A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
http://purl.obolibrary.org/obo/CHEBI_35489	organic disulfide	http://purl.obolibrary.org/obo/CHEBI_48343	disulfide		Compounds of structure RSSR in which R and R' are organic groups.
http://purl.obolibrary.org/obo/CHEBI_35610	antineoplastic agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A substance that inhibits or prevents the proliferation of neoplasms.
http://purl.obolibrary.org/obo/CHEBI_35618	aromatic ether	http://purl.obolibrary.org/obo/CHEBI_33659	organic aromatic compound		Any ether in which the oxygen is attached to at least one aryl substituent.
http://purl.obolibrary.org/obo/CHEBI_35620	vasodilator agent	http://purl.obolibrary.org/obo/CHEBI_35554	cardiovascular drug		A drug used to cause dilation of the blood vessels.
http://purl.obolibrary.org/obo/CHEBI_35623	anticonvulsant	http://purl.obolibrary.org/obo/CHEBI_35488	central nervous system depressant		A drug used to prevent seizures or reduce their severity.
http://purl.obolibrary.org/obo/CHEBI_35681	secondary alcohol	http://purl.obolibrary.org/obo/CHEBI_30879	alcohol		A secondary alcohol is a compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
http://purl.obolibrary.org/obo/CHEBI_35703	xenobiotic	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A xenobiotic (Greek, <em>xenos</em> "foreign"; <em>bios</em> "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
http://purl.obolibrary.org/obo/CHEBI_35718	antifungal agent	http://purl.obolibrary.org/obo/CHEBI_33281	antimicrobial agent		An  antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
http://purl.obolibrary.org/obo/CHEBI_35748	fatty acid ester	http://purl.obolibrary.org/obo/CHEBI_33308	carboxylic ester		A carboxylic ester in which the carboxylic acid component can be any fatty acid.
http://purl.obolibrary.org/obo/CHEBI_35871	oxo monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_25754	oxo carboxylic acid		Any monocarboxylic acid having at least one additional oxo functional group.
http://purl.obolibrary.org/obo/CHEBI_36044	antiviral drug	http://purl.obolibrary.org/obo/CHEBI_36043	antimicrobial drug		A substance used in the prophylaxis or therapy of virus diseases.
http://purl.obolibrary.org/obo/CHEBI_36586	carbonyl compound	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound	http://purl.obolibrary.org/obo/CHEBI_36962	organochalcogen compound		An organochalcogen compound containing at least one carbon-oxygen bond.
http://purl.obolibrary.org/obo/CHEBI_37581	gamma-lactone	http://purl.obolibrary.org/obo/CHEBI_25000	lactone		A lactone having a five-membered lactone ring.
http://purl.obolibrary.org/obo/CHEBI_37622	carboxamide	http://purl.obolibrary.org/obo/CHEBI_33256	primary amide		An amide of a carboxylic acid, having the structure RC(=O)NR<small><sub>2</sub></small>. The term is used as a suffix in systematic name formation to denote the ‒C(=O)NH<small><sub>2</sub></small> group including its carbon atom.
http://purl.obolibrary.org/obo/CHEBI_38104	oxacycle	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		Any organic heterocyclic compound containing at least one ring oxygen atom.
http://purl.obolibrary.org/obo/CHEBI_38958	indole alkaloid	http://purl.obolibrary.org/obo/CHEBI_22315	alkaloid		An alkaloid containing an indole skeleton.
http://purl.obolibrary.org/obo/CHEBI_38976	alkylbenzene	http://purl.obolibrary.org/obo/CHEBI_33847	monocyclic arene		A  monocyclic arene that is benzene substituted with one or more alkyl groups.
http://purl.obolibrary.org/obo/CHEBI_39447	pyrimidines	http://purl.obolibrary.org/obo/CHEBI_38313	diazines		Any compound having a pyrimidine as part of its structure.
http://purl.obolibrary.org/obo/CHEBI_46761	dipeptide	http://purl.obolibrary.org/obo/CHEBI_25676	oligopeptide		Any molecule that contains two amino-acid residues connected by peptide linkages.
http://purl.obolibrary.org/obo/CHEBI_49167	anti-asthmatic drug	http://purl.obolibrary.org/obo/CHEBI_65023	anti-asthmatic agent		A drug used to treat asthma.
http://purl.obolibrary.org/obo/CHEBI_50176	keratolytic drug	http://purl.obolibrary.org/obo/CHEBI_50177	dermatologic drug		A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
http://purl.obolibrary.org/obo/CHEBI_50249	anticoagulant	http://purl.obolibrary.org/obo/CHEBI_50248	hematologic agent		An agent that prevents blood clotting.
http://purl.obolibrary.org/obo/CHEBI_50267	protective agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
http://purl.obolibrary.org/obo/CHEBI_50514	vasoconstrictor agent	http://purl.obolibrary.org/obo/CHEBI_35554	cardiovascular drug		Drug used to cause constriction of the blood vessels.
http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity	http://purl.obolibrary.org/obo/CHEBI_33582	carbon group molecular entity		Any molecular entity that contains carbon.
http://purl.obolibrary.org/obo/CHEBI_50903	carcinogenic agent	http://purl.obolibrary.org/obo/CHEBI_52209	aetiopathogenetic role		A role played by a chemical compound which is known to  induce a process of carcinogenesis  by corrupting  normal cellular pathways, leading to the acquistion of tumoral capabilities.
http://purl.obolibrary.org/obo/CHEBI_50921	fumarate salt	http://purl.obolibrary.org/obo/CHEBI_24868	organic salt		An organic salt derived from fumaric acid.
http://purl.obolibrary.org/obo/CHEBI_50996	tertiary amino compound	http://purl.obolibrary.org/obo/CHEBI_50047	organic amino compound		A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
http://purl.obolibrary.org/obo/CHEBI_51569	N-acyl-amino acid	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		A carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid.
http://purl.obolibrary.org/obo/CHEBI_51683	methoxybenzenes	http://purl.obolibrary.org/obo/CHEBI_35618	aromatic ether		Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups.
http://purl.obolibrary.org/obo/CHEBI_51689	enone	http://purl.obolibrary.org/obo/CHEBI_51721	alpha,beta-unsaturated ketone		An α,β-unsaturated ketone of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)R<small><sup>4</small></sup> (R<small><sup>4</small></sup> ≠ H) in which the C=O function is conjugated to a C=C double bond at the α,β position.
http://purl.obolibrary.org/obo/CHEBI_52214	ligand	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		Any molecule or ion capable of binding to a central metal atom to form coordination complexes.
http://purl.obolibrary.org/obo/CHEBI_55370	imidazolidinone	http://purl.obolibrary.org/obo/CHEBI_38261	imidazolidines		An imidazolidine containing one or more oxo groups.
http://purl.obolibrary.org/obo/CHEBI_60027	polymer	http://purl.obolibrary.org/obo/CHEBI_60004	mixture		A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc..
http://purl.obolibrary.org/obo/CHEBI_60911	racemate	http://purl.obolibrary.org/obo/CHEBI_60004	mixture		A racemate is an equimolar mixture of a pair of enantiomers.
http://purl.obolibrary.org/obo/CHEBI_62868	hepatoprotective agent	http://purl.obolibrary.org/obo/CHEBI_50267	protective agent		Any compound that is able to prevent damage to the liver.
http://purl.obolibrary.org/obo/CHEBI_63367	monosaccharide derivative	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		A carbohydrate derivative that is formally obtained from a monosaccharide.
http://purl.obolibrary.org/obo/CHEBI_63726	neuroprotective agent	http://purl.obolibrary.org/obo/CHEBI_50267	protective agent		Any compound that can be used for the treatment of neurodegenerative disorders.
http://purl.obolibrary.org/obo/CHEBI_65023	anti-asthmatic agent	http://purl.obolibrary.org/obo/CHEBI_33232	application		Any compound that has anti-asthmatic effects.
http://purl.obolibrary.org/obo/CHEBI_67142	nucleobase analogue	http://purl.obolibrary.org/obo/CHEBI_33832	organic cyclic compound		A molecule that can substitute for a normal nucleobase in nucleic acids.
http://purl.obolibrary.org/obo/CHEBI_75767	animal metabolite	http://purl.obolibrary.org/obo/CHEBI_75763	eukaryotic metabolite		Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
http://purl.obolibrary.org/obo/CHEBI_75771	mouse metabolite	http://purl.obolibrary.org/obo/CHEBI_75768	mammalian metabolite		Any mammalian metabolite produced during a metabolic reaction in a mouse (<em>Mus musculus</em>).
http://purl.obolibrary.org/obo/CHEBI_76924	plant metabolite	http://purl.obolibrary.org/obo/CHEBI_75763	eukaryotic metabolite		Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
http://purl.obolibrary.org/obo/CHEBI_76946	fungal metabolite	http://purl.obolibrary.org/obo/CHEBI_75763	eukaryotic metabolite		Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
http://purl.obolibrary.org/obo/CHEBI_76971	Escherichia coli metabolite	http://purl.obolibrary.org/obo/CHEBI_76969	bacterial metabolite		Any bacterial metabolite produced during a metabolic reaction in <em>Escherichia coli</em>.
http://purl.obolibrary.org/obo/CHEBI_78298	environmental contaminant	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		Any minor or unwanted substance introduced into the environment that can have undesired effects.
http://purl.obolibrary.org/obo/CHEBI_78840	olefinic compound	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		Any organic molecular entity that contains at least one C=C bond.
http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		Any  α-amino acid which is not a member of the group of 23 proteinogenic amino acids.
http://purl.obolibrary.org/obo/CHEBI_88188	drug allergen	http://purl.obolibrary.org/obo/CHEBI_23888	drug		Any drug which causes the onset of an allergic reaction.
http://purl.obolibrary.org/obo/CHEBI_16070	1,5-anhydro-D-glucitol	http://purl.obolibrary.org/obo/CHEBI_22558	anhydro sugar		An anhydro sugar of <small>D</small>-glucitol.
http://purl.obolibrary.org/obo/CHEBI_17261	N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine	http://purl.obolibrary.org/obo/CHEBI_21836	N(4)-glycosyl-L-asparagine		An <em>N</em><small><sup>4</small></sup>-glycosyl-<small>L</small>-asparagine having (β-<em>N</em>-acetyl-<small>D</small>-glucosaminyl as the glycosyl component.
http://purl.obolibrary.org/obo/CHEBI_17418	valeric acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A straight-chain saturated fatty acid containing five carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_23354	coenzyme	http://purl.obolibrary.org/obo/CHEBI_23357	cofactor		A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons.
http://purl.obolibrary.org/obo/CHEBI_26401	purines	http://purl.obolibrary.org/obo/CHEBI_35875	imidazopyrimidine		A class of imidazopyrimidines that consists of purine and its substituted derivatives.
http://purl.obolibrary.org/obo/CHEBI_27136	triol	http://purl.obolibrary.org/obo/CHEBI_26191	polyol		A chemical compound containing three hydroxy groups.
http://purl.obolibrary.org/obo/CHEBI_27314	water-soluble vitamin (role)	http://purl.obolibrary.org/obo/CHEBI_33229	vitamin (role)		Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
http://purl.obolibrary.org/obo/CHEBI_30772	butyric acid	http://purl.obolibrary.org/obo/CHEBI_140601	fatty acid 4:0		A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.
http://purl.obolibrary.org/obo/CHEBI_33655	aromatic compound	http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound		A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekulé structure) is said to possess aromatic character.
http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		Any carboxylic acid containing two carboxy groups.
http://purl.obolibrary.org/obo/CHEBI_37808	butane	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		A straight chain alkane composed of 4 carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_50994	primary amino compound	http://purl.obolibrary.org/obo/CHEBI_50047	organic amino compound		A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
http://purl.obolibrary.org/obo/CHEBI_59266	amino trisaccharide	http://purl.obolibrary.org/obo/CHEBI_22483	amino oligosaccharide		An amino oligosaccharide that is a trisaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.
http://purl.obolibrary.org/obo/CHEBI_59835	hydroxy fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		The conjugate base of any hydroxy fatty acid, formed by deprotonation of the carboxylic acid moiety.
http://purl.obolibrary.org/obo/CHEBI_64577	flour treatment agent	http://purl.obolibrary.org/obo/CHEBI_64047	food additive		A food additive which is added to flour or dough to improve baking quality and/or colour.
http://purl.obolibrary.org/obo/CHEBI_65256	antimicrobial food preservative	http://purl.obolibrary.org/obo/CHEBI_33281	antimicrobial agent		A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299).
http://purl.obolibrary.org/obo/CHEBI_75763	eukaryotic metabolite	http://purl.obolibrary.org/obo/CHEBI_25212	metabolite		Any  metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
http://purl.obolibrary.org/obo/CHEBI_76969	bacterial metabolite	http://purl.obolibrary.org/obo/CHEBI_75787	prokaryotic metabolite		Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
http://purl.obolibrary.org/obo/CHEBI_79020	alpha,beta-unsaturated monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		A monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C≡C bond.
http://purl.obolibrary.org/obo/CHEBI_84735	algal metabolite	http://purl.obolibrary.org/obo/CHEBI_75763	eukaryotic metabolite		Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae.
http://purl.obolibrary.org/obo/CHEBI_87658	decanoate ester	http://purl.obolibrary.org/obo/CHEBI_35748	fatty acid ester		A fatty acid ester resulting from the formal condensation of the carboxy group of decanoic acid (capric acid) with the hydroxy group of an alcohol or phenol.
http://purl.obolibrary.org/obo/CHEBI_15778	N-acyl-D-amino acid	http://purl.obolibrary.org/obo/CHEBI_51569	N-acyl-amino acid		Any <em>N</em>-acyl-amino acid in which the amino acid moiety has <small>D</small> configuration.
http://purl.obolibrary.org/obo/CHEBI_16498	N-acylneuraminic acid	http://purl.obolibrary.org/obo/CHEBI_26667	sialic acid		Any neuraminic acid carrying an <em>N</em>-acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_16856	glutathione	http://purl.obolibrary.org/obo/CHEBI_47923	tripeptide		A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
http://purl.obolibrary.org/obo/CHEBI_17724	N,N-dimethylglycine	http://purl.obolibrary.org/obo/CHEBI_21766	N-methylglycines		An <em>N</em>-methylglycine that is glycine carrying two <em>N</em>-methyl substituents.
http://purl.obolibrary.org/obo/CHEBI_17761	ceramide	http://purl.obolibrary.org/obo/CHEBI_26739	sphingolipid		Ceramides (<em>N</em>-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R<small><sup>1</small></sup> = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H.
http://purl.obolibrary.org/obo/CHEBI_18259	N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide	http://purl.obolibrary.org/obo/CHEBI_88167	N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide		A glycotetraosylceramide having <em>N</em>-acetyl-β-<small>D</small>-galactosaminyl-(1→3)-α-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucose as the tetrasaccharide component.
http://purl.obolibrary.org/obo/CHEBI_33497	transition element molecular entity	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		A molecular entity containing one or more atoms of a transition element.
http://purl.obolibrary.org/obo/CHEBI_35418	N-acetylneuraminate	http://purl.obolibrary.org/obo/CHEBI_21619	N-acetylneuraminates		A ketoaldonate that is the conjugate base of <em>N</em>-acetylneuraminic acid, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_53000	epitope	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
http://purl.obolibrary.org/obo/CHEBI_62499	methyl-branched fatty acid	http://purl.obolibrary.org/obo/CHEBI_35819	branched-chain fatty acid		Any branched-chain fatty acid containing methyl branches only.
http://purl.obolibrary.org/obo/CHEBI_12777	vitamin A	http://purl.obolibrary.org/obo/CHEBI_26537	retinoid		Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.
http://purl.obolibrary.org/obo/CHEBI_16680	S-adenosyl-L-homocysteine	http://purl.obolibrary.org/obo/CHEBI_16385	organic sulfide		An organic sulfide that is the <em>S</em>-adenosyl derivative of <small>L</small>-homocysteine.
http://purl.obolibrary.org/obo/CHEBI_16953	N-acetyl-L-aspartate(2-)	http://purl.obolibrary.org/obo/CHEBI_233443	N-acetyl-L-alpha-amino acid anion		A doubly-charged <em>N</em>-acyl-<small>L</small>-α-amino acid anion resulting from deprotonation of both carboxy groups of <em>N</em>-acetyl-<small>L</small>-aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine	http://purl.obolibrary.org/obo/CHEBI_33308	carboxylic ester		Any carboxylic ester obtained by the <em>O</em>-acylation of carnitine.
http://purl.obolibrary.org/obo/CHEBI_17522	alditol	http://purl.obolibrary.org/obo/CHEBI_16646	carbohydrate		A carbohydrate that is an acyclic polyol having the general formula HOCH<small><sub>2</sub></small>[CH(OH)]<small><sub><em>n</em></sub></small>CH<small><sub>2</sub></small>OH (formally derivable from an aldose by reduction of the carbonyl group).
http://purl.obolibrary.org/obo/CHEBI_18133	hexose	http://purl.obolibrary.org/obo/CHEBI_35381	monosaccharide		Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose).
http://purl.obolibrary.org/obo/CHEBI_24020	fat-soluble vitamin (role)	http://purl.obolibrary.org/obo/CHEBI_33229	vitamin (role)		Any vitamin that dissolves in fats and are stored in body tissues. Unlike the water-soluble vitamins, they are stored in the body for long periods of time and generally pose a greater risk for toxicity when consumed in excess.
http://purl.obolibrary.org/obo/CHEBI_26537	retinoid	http://purl.obolibrary.org/obo/CHEBI_23849	diterpenoid		Oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.
http://purl.obolibrary.org/obo/CHEBI_27689	decanoate	http://purl.obolibrary.org/obo/CHEBI_194240	omega-methyl-medium-chain fatty acid anion		A fatty acid anion 10:0 that is the conjugate base of decanoic acid.
http://purl.obolibrary.org/obo/CHEBI_28790	serotonin	http://purl.obolibrary.org/obo/CHEBI_25375	monoamine molecular messenger		A primary amino compound that is the 5-hydroxy derivative of tryptamine.
http://purl.obolibrary.org/obo/CHEBI_30751	formic acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.
http://purl.obolibrary.org/obo/CHEBI_30915	2-oxoglutaric acid	http://purl.obolibrary.org/obo/CHEBI_36145	oxo dicarboxylic acid		An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.
http://purl.obolibrary.org/obo/CHEBI_32816	pyruvic acid	http://purl.obolibrary.org/obo/CHEBI_35910	2-oxo monocarboxylic acid		A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.
http://purl.obolibrary.org/obo/CHEBI_35381	monosaccharide	http://purl.obolibrary.org/obo/CHEBI_16646	carbohydrate		Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]<small><sub><em>n</em></sub></small>C(=O)H or polyhydroxy ketones H‒[CHOH]<small><sub><em>n</em></sub></small>‒C(=O)[CHOH]<small><sub><em>m</em></sub></small>‒H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.
http://purl.obolibrary.org/obo/CHEBI_35523	bronchodilator agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
http://purl.obolibrary.org/obo/CHEBI_57560	long-chain fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		A fatty acid anion with a chain length of C<small><sub>13</sub></small> to C<small><sub>22</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_61115	EC 3.5.1.98 (histone deacetylase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76807	EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor		An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
http://purl.obolibrary.org/obo/CHEBI_15966	D-glutamic acid	http://purl.obolibrary.org/obo/CHEBI_16733	D-alpha-amino acid		An optically active form of glutamic acid having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_16015	L-glutamic acid	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		An optically active form of glutamic acid having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_16541	protein polypeptide chain	http://purl.obolibrary.org/obo/CHEBI_15841	polypeptide		A naturally occurring polypeptide synthesized at the ribosome.
http://purl.obolibrary.org/obo/CHEBI_16742	orotic acid	http://purl.obolibrary.org/obo/CHEBI_26447	pyrimidinemonocarboxylic acid		A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
http://purl.obolibrary.org/obo/CHEBI_17012	N-acetylneuraminic acid	http://purl.obolibrary.org/obo/CHEBI_21622	N-acetylneuraminic acids		An <em>N</em>-acylneuraminic acid where the <em>N</em>-acyl group is specified as acetyl.
http://purl.obolibrary.org/obo/CHEBI_17053	L-aspartic acid	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		The <small>L</small>-enantiomer of aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_17364	D-aspartic acid	http://purl.obolibrary.org/obo/CHEBI_16733	D-alpha-amino acid		The <small>D</small>-enantiomer of aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_17497	glycolic acid	http://purl.obolibrary.org/obo/CHEBI_15734	primary alcohol		A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.
http://purl.obolibrary.org/obo/CHEBI_20067	3-hydroxybutyric acid	http://purl.obolibrary.org/obo/CHEBI_78954	(omega-1)-hydroxy fatty acid		A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
http://purl.obolibrary.org/obo/CHEBI_20392	4-hydroxyproline	http://purl.obolibrary.org/obo/CHEBI_86499	monohydroxyproline		A monohydroxyproline where the hydroxy group is located at the 4-position. It is found in  fibrillar collagen.
http://purl.obolibrary.org/obo/CHEBI_20702	2-aminopurines	http://purl.obolibrary.org/obo/CHEBI_22527	aminopurine		Any aminopurine having the amino substituent at the 2-position.
http://purl.obolibrary.org/obo/CHEBI_21501	N-acetyl-D-amino acid	http://purl.obolibrary.org/obo/CHEBI_21575	N-acetyl-amino acid		An <em>N</em>-acetyl-amino acid having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_21547	N-acetyl-L-aspartic acid	http://purl.obolibrary.org/obo/CHEBI_21647	N-acyl-L-aspartic acid		An <em>N</em>-acyl-<small>L</small>-aspartic acid in which the acyl group is specified as acetyl.
http://purl.obolibrary.org/obo/CHEBI_21575	N-acetyl-amino acid	http://purl.obolibrary.org/obo/CHEBI_22195	acetyl-amino acid		An <em>N</em>-acyl-amino acid that has acetyl as the acyl group.
http://purl.obolibrary.org/obo/CHEBI_21654	N-acyl-aspartic acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		An aspartic acid derivative that is aspartic acid in which one of the hydrogens attached to the amino group is replaced by an acyl group.
http://purl.obolibrary.org/obo/CHEBI_22195	acetyl-amino acid	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		Any amino acid derivative that is the <em>N</em>-acetyl or <em>O</em>-acetyl derivative of an amino acid.
http://purl.obolibrary.org/obo/CHEBI_22558	anhydro sugar	http://purl.obolibrary.org/obo/CHEBI_35381	monosaccharide		Intramolecular ethers formally arising by elimination of water from two hydroxy groups of a single molecule of a monosaccharide (aldose or ketose) or monosaccharide derivative.
http://purl.obolibrary.org/obo/CHEBI_22658	aspartate family amino acid	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		An <small>L</small>-α-amino acid which is <small>L</small>-aspartic acid or any of the essential amino acids biosynthesised from it (asparagine, lysine, methionine, threonine and isoleucine). A closed class.
http://purl.obolibrary.org/obo/CHEBI_22676	auxin	http://purl.obolibrary.org/obo/CHEBI_37848	plant hormone		Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek αυξανω, "to grow").
http://purl.obolibrary.org/obo/CHEBI_23240	chromophore	http://purl.obolibrary.org/obo/CHEBI_52215	photochemical role		The part (atom or group of atoms) of a molecular entity in which the electronic transition responsible for a given spectral band is approximately localized.
http://purl.obolibrary.org/obo/CHEBI_23965	estradiol	http://purl.obolibrary.org/obo/CHEBI_177917	phenolic steroid		A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17.
http://purl.obolibrary.org/obo/CHEBI_24149	galactonic acid	http://purl.obolibrary.org/obo/CHEBI_33752	hexonic acid		A hexonic acid that has been found to increase in red blood cells of galactosemic patients.
http://purl.obolibrary.org/obo/CHEBI_24261	glucocorticoid	http://purl.obolibrary.org/obo/CHEBI_36699	corticosteroid hormone		Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.
http://purl.obolibrary.org/obo/CHEBI_24273	glucosaminylamine	http://purl.obolibrary.org/obo/CHEBI_24271	glucosamines		A member of the class of  glucosamines that is 2-amino-2-deoxyglucose  in which the anomeric hydroxy group has been replaced by an additional amino group.
http://purl.obolibrary.org/obo/CHEBI_24318	glutamine family amino acid	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		An <small>L</small>-α-amino acid which is <small>L</small>-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.
http://purl.obolibrary.org/obo/CHEBI_24396	glycopeptide	http://purl.obolibrary.org/obo/CHEBI_16670	peptide		Any carbohydrate derivative that consists of glycan moieties covalently attached to the side chains of the amino acid residues that constitute the peptide.
http://purl.obolibrary.org/obo/CHEBI_24458	guanosines	http://purl.obolibrary.org/obo/CHEBI_26399	purine ribonucleoside		Any purine ribonucleoside that is a derivative of guanosine.
http://purl.obolibrary.org/obo/CHEBI_24669	hydroxy carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		Any carboxylic acid with at least one hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_24996	lactate	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		A hydroxy monocarboxylic acid anion that is the conjugate base of lactic acid, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_25094	lysine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.
http://purl.obolibrary.org/obo/CHEBI_25354	mineralocorticoid	http://purl.obolibrary.org/obo/CHEBI_36699	corticosteroid hormone		Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism.
http://purl.obolibrary.org/obo/CHEBI_25375	monoamine molecular messenger	http://purl.obolibrary.org/obo/CHEBI_63534	monoamine		A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (‒CH<small><sub>2</sub></small>‒CH<small><sub>2</sub></small>‒). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.
http://purl.obolibrary.org/obo/CHEBI_25608	nucleoside phosphate	http://purl.obolibrary.org/obo/CHEBI_37734	phosphoric ester		A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates.
http://purl.obolibrary.org/obo/CHEBI_25798	oxopentanoates	http://purl.obolibrary.org/obo/CHEBI_59836	oxo fatty acid anion		The conjugate base of any oxopentanoic acid.
http://purl.obolibrary.org/obo/CHEBI_25801	oxoproline	http://purl.obolibrary.org/obo/CHEBI_26273	proline derivative		A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent.
http://purl.obolibrary.org/obo/CHEBI_25899	pentitol	http://purl.obolibrary.org/obo/CHEBI_17522	alditol		An alditol obtained by reduction of any pentose.
http://purl.obolibrary.org/obo/CHEBI_26078	phosphoric acid	http://purl.obolibrary.org/obo/CHEBI_59698	phosphoric acids		A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.
http://purl.obolibrary.org/obo/CHEBI_26130	biological pigment	http://purl.obolibrary.org/obo/CHEBI_52208	biophysical role		An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light.
http://purl.obolibrary.org/obo/CHEBI_26199	polyprenol	http://purl.obolibrary.org/obo/CHEBI_26244	prenols		Any member of the class of  prenols possessing the general formula H-[CH2C(Me)=CHCH2]nOH in which the carbon skeleton is composed of more than one isoprene units.
http://purl.obolibrary.org/obo/CHEBI_26244	prenols	http://purl.obolibrary.org/obo/CHEBI_30879	alcohol		Any alcohol possessing the general formula H-[CH<small><sub>2</sub></small>C(Me)=CHCH<small><sub>2</sub></small>]<small><sub><em>n</em></sub></small>OH in which the carbon skeleton is composed of one or more isoprene units (biogenetic precursors of the isoprenoids).
http://purl.obolibrary.org/obo/CHEBI_26271	proline	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.
http://purl.obolibrary.org/obo/CHEBI_26667	sialic acid	http://purl.obolibrary.org/obo/CHEBI_25508	neuraminic acids		Any of the <em>N</em>-acylneuraminic acids and their esters and other derivatives of the alcoholic hydroxy groups.
http://purl.obolibrary.org/obo/CHEBI_26822	sulfide	http://purl.obolibrary.org/obo/CHEBI_26835	sulfur molecular entity		Any sulfur molecular entity that involves either covalently bonded or anionic sulfur.
http://purl.obolibrary.org/obo/CHEBI_26986	threonine	http://purl.obolibrary.org/obo/CHEBI_38263	2-amino-3-hydroxybutanoic acid		An α-amino acid in which one of the hydrogens attached to the α-carbon of glycine is substituted by a 1-hydroxyethyl group.
http://purl.obolibrary.org/obo/CHEBI_27266	valine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the α-carbon is substituted by an isopropyl group.
http://purl.obolibrary.org/obo/CHEBI_27389	3-aminoisobutyric acid	http://purl.obolibrary.org/obo/CHEBI_33706	beta-amino acid		A β-amino-acid that is isobutyric acid in which one of the methyl hydrogens is substituted by an amino group.
http://purl.obolibrary.org/obo/CHEBI_27570	histidine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1<em>H</em>-imidazol-4-yl group at position 3.
http://purl.obolibrary.org/obo/CHEBI_27897	tryptophan	http://purl.obolibrary.org/obo/CHEBI_38631	aminoalkylindole		An α-amino acid that is alanine bearing an indol-3-yl substituent at position 3.
http://purl.obolibrary.org/obo/CHEBI_28044	phenylalanine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.
http://purl.obolibrary.org/obo/CHEBI_28300	glutamine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.
http://purl.obolibrary.org/obo/CHEBI_28600	farnesol	http://purl.obolibrary.org/obo/CHEBI_15734	primary alcohol		A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.
http://purl.obolibrary.org/obo/CHEBI_28938	ammonium	http://purl.obolibrary.org/obo/CHEBI_50313	onium cation		An onium cation obtained by protonation of ammonia.
http://purl.obolibrary.org/obo/CHEBI_29016	arginine	http://purl.obolibrary.org/obo/CHEBI_24436	guanidines		An α-amino acid that is glycine in which the α-is substituted by a 3-guanidinopropyl group.
http://purl.obolibrary.org/obo/CHEBI_29988	L-glutamate(2-)	http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion		An <small>L</small>-α-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of <small>L</small>-glutamic acid.
http://purl.obolibrary.org/obo/CHEBI_29993	L-aspartate(2-)	http://purl.obolibrary.org/obo/CHEBI_29995	aspartate(2-)		An aspartate(2−) that is the conjugate base of  <small>L</small>-aspartate(1−).
http://purl.obolibrary.org/obo/CHEBI_30411	cobalamin	http://purl.obolibrary.org/obo/CHEBI_23334	cobalamins		A cobalt-corrinoid hexaamide that is cobalamin with the oxidation state of the central cobalt atom unspecified.
http://purl.obolibrary.org/obo/CHEBI_30832	adipic acid	http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid		An α,ω-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.
http://purl.obolibrary.org/obo/CHEBI_30833	adipate(1-)	http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion		A dicarboxylic acid monoanion that is the conjugate base of adipic acid.
http://purl.obolibrary.org/obo/CHEBI_30860	methylmalonic acid	http://purl.obolibrary.org/obo/CHEBI_66873	C4-dicarboxylic acid		A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
http://purl.obolibrary.org/obo/CHEBI_30916	2-oxoglutarate(1-)	http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion		A dicarboxylic acid monoanion resulting from selective deprotonation of the 1-carboxy group of 2-oxoglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_30920	3-hydroxy-3-methylglutarate(1-)	http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion		A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of 3-hydroxy-3-methylglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_32439	alaninate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of alanine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32440	alaninium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of alanine.
http://purl.obolibrary.org/obo/CHEBI_32449	D-cysteinate(1-)	http://purl.obolibrary.org/obo/CHEBI_32456	cysteinate(1-)		The <small>D</small>-enantiomer of cysteinate(1−).
http://purl.obolibrary.org/obo/CHEBI_32451	D-cysteinium	http://purl.obolibrary.org/obo/CHEBI_32458	cysteinium		The <small>D</small>-enantiomer of cysteinium.
http://purl.obolibrary.org/obo/CHEBI_32631	L-methioninate	http://purl.obolibrary.org/obo/CHEBI_32644	methioninate		The <small>L</small>-enantiomer of  methioninate.
http://purl.obolibrary.org/obo/CHEBI_32632	L-methioninium	http://purl.obolibrary.org/obo/CHEBI_32646	methioninium		The <small>L</small>-enantiomer of methioninium.
http://purl.obolibrary.org/obo/CHEBI_32637	D-methioninate	http://purl.obolibrary.org/obo/CHEBI_32644	methioninate		The <small>D</small>-enantiomer of methioninate.
http://purl.obolibrary.org/obo/CHEBI_32638	D-methioninium	http://purl.obolibrary.org/obo/CHEBI_32646	methioninium		The <small>D</small>-enantiomer of methioninium.
http://purl.obolibrary.org/obo/CHEBI_32644	methioninate	http://purl.obolibrary.org/obo/CHEBI_63470	sulfur-containing amino-acid anion		A sulfur-containing amino-acid anion that is the conjugate base of methionine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32646	methioninium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		A sulfur-containing amino-acid cation that is the conjugate acid of methionine, arising from protonation of the amino group.
http://purl.obolibrary.org/obo/CHEBI_32867	D-prolinate	http://purl.obolibrary.org/obo/CHEBI_32871	prolinate		An optically active form of prolinate having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_32868	D-prolinium	http://purl.obolibrary.org/obo/CHEBI_32872	prolinium		An optically active form of prolinium having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_32970	2-aminoethanesulfonate	http://purl.obolibrary.org/obo/CHEBI_62081	1,1-diunsubstituted alkanesulfonate		A 1,1-diunsubstituted alkanesulfonate that is ethanesulfonate substituted by an amino group at position 2.
http://purl.obolibrary.org/obo/CHEBI_33256	primary amide	http://purl.obolibrary.org/obo/CHEBI_32988	amide		A derivative of an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
http://purl.obolibrary.org/obo/CHEBI_33287	fertilizer	http://purl.obolibrary.org/obo/CHEBI_33286	agrochemical		A fertilizer is any substance that is added to soil or water to assist the growth of plants.
http://purl.obolibrary.org/obo/CHEBI_33295	diagnostic agent	http://purl.obolibrary.org/obo/CHEBI_52217	pharmaceutical		A substance administered to aid diagnosis of a disease.
http://purl.obolibrary.org/obo/CHEBI_33405	hydracid	http://purl.obolibrary.org/obo/CHEBI_33608	hydrogen molecular entity		A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
http://purl.obolibrary.org/obo/CHEBI_33457	phosphorus oxoacid	http://purl.obolibrary.org/obo/CHEBI_33408	pnictogen oxoacid		A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons.
http://purl.obolibrary.org/obo/CHEBI_33576	sulfur-containing carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		Any carboxylic acid having a sulfur substituent.
http://purl.obolibrary.org/obo/CHEBI_33837	conjugated protein	http://purl.obolibrary.org/obo/CHEBI_36080	protein		Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion.
http://purl.obolibrary.org/obo/CHEBI_33839	macromolecule	http://purl.obolibrary.org/obo/CHEBI_36357	polyatomic entity		A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/CHEBI_33942	ribose	http://purl.obolibrary.org/obo/CHEBI_33916	aldopentose		Any aldopentose where the open-chain form has all the hydroxy groups on the same side in the Fischer projection. Occurrs in two enantiomeric forms, <small>D</small>- and <small>L</small>-ribose, of which only the former is found in nature.
http://purl.obolibrary.org/obo/CHEBI_3424	carnitinium	http://purl.obolibrary.org/obo/CHEBI_35267	quaternary ammonium ion		A quaternary ammonium ion that is the the conjugate acid of carnitine.
http://purl.obolibrary.org/obo/CHEBI_35282	sulfonium betaine	http://purl.obolibrary.org/obo/CHEBI_35281	onium betaine		Neutral molecules having charge-separated forms with an sulfonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
http://purl.obolibrary.org/obo/CHEBI_35589	9H-purine	http://purl.obolibrary.org/obo/CHEBI_35584	purine		The 9<em>H</em>-tautomer of purine.
http://purl.obolibrary.org/obo/CHEBI_35664	EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76835	EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor		Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD<small><sup>+</small></sup> or NADP<small><sup>+</small></sup> acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
http://purl.obolibrary.org/obo/CHEBI_35679	antilipemic drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A substance used to treat hyperlipidemia (an excess of lipids in the blood).
http://purl.obolibrary.org/obo/CHEBI_35701	ester	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		A compound formally derived from an oxoacid R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.
http://purl.obolibrary.org/obo/CHEBI_35808	citrate(2-)	http://purl.obolibrary.org/obo/CHEBI_36300	tricarboxylic acid dianion		A tricarboxylic acid dianion obtained by deprotonation of two of the three carboxy groups of citric acid.
http://purl.obolibrary.org/obo/CHEBI_35821	anticholesteremic drug	http://purl.obolibrary.org/obo/CHEBI_35679	antilipemic drug		A substance used to lower plasma cholesterol levels.
http://purl.obolibrary.org/obo/CHEBI_35825	mandelic acid	http://purl.obolibrary.org/obo/CHEBI_22712	benzenes		A 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups.
http://purl.obolibrary.org/obo/CHEBI_36009	omega-6 fatty acid	http://purl.obolibrary.org/obo/CHEBI_26208	polyunsaturated fatty acid		A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the n-6 position, i.e., the sixth bond from the methyl end of the fatty acid.
http://purl.obolibrary.org/obo/CHEBI_36043	antimicrobial drug	http://purl.obolibrary.org/obo/CHEBI_35441	antiinfective agent		A drug used to treat or prevent microbial infections.
http://purl.obolibrary.org/obo/CHEBI_37395	mucopolysaccharide	http://purl.obolibrary.org/obo/CHEBI_18085	glycosaminoglycan		Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid.
http://purl.obolibrary.org/obo/CHEBI_37631	beta-L-glucose	http://purl.obolibrary.org/obo/CHEBI_37627	L-glucopyranose		A <small>L</small>-glucopyranose with a β-configuration at the anomeric position.
http://purl.obolibrary.org/obo/CHEBI_37848	plant hormone	http://purl.obolibrary.org/obo/CHEBI_24621	hormone		A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds.
http://purl.obolibrary.org/obo/CHEBI_37962	adrenergic agent	http://purl.obolibrary.org/obo/CHEBI_35942	neurotransmitter agent		Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_59202	straight-chain fatty acid		Any saturated fatty acid lacking a side-chain.
http://purl.obolibrary.org/obo/CHEBI_4167	D-glucopyranose	http://purl.obolibrary.org/obo/CHEBI_17634	D-glucose		A glucopyranose having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_422	(S)-lactic acid	http://purl.obolibrary.org/obo/CHEBI_78320	2-hydroxypropanoic acid		An optically active form of lactic acid having (<i>S</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_46787	solvent	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A liquid that can dissolve other substances (solutes) without any change in their chemical composition.
http://purl.obolibrary.org/obo/CHEBI_46997	L-ribose	http://purl.obolibrary.org/obo/CHEBI_33942	ribose		A ribose in which the chiral carbon atom furthest away from the aldehyde group (C4') has the same configuration as in <small>L</small>-glyceraldehyde.
http://purl.obolibrary.org/obo/CHEBI_47923	tripeptide	http://purl.obolibrary.org/obo/CHEBI_25676	oligopeptide		Any oligopeptide that consists of three amino-acid residues connected by peptide linkages.
http://purl.obolibrary.org/obo/CHEBI_48299	butane-1,2,3,4-tetrol	http://purl.obolibrary.org/obo/CHEBI_33729	tetritol		A tetritol that is butane substituted by hydroxy groups at positions 1, 2, 3 and 4.
http://purl.obolibrary.org/obo/CHEBI_48354	polar solvent	http://purl.obolibrary.org/obo/CHEBI_46787	solvent		A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.
http://purl.obolibrary.org/obo/CHEBI_48560	dopaminergic agent	http://purl.obolibrary.org/obo/CHEBI_35942	neurotransmitter agent		A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
http://purl.obolibrary.org/obo/CHEBI_49033	methionine S-oxide	http://purl.obolibrary.org/obo/CHEBI_25230	methionine derivative		The <em>S</em>-oxide derivative of methionine. It is a biomarker of oxidative stress.
http://purl.obolibrary.org/obo/CHEBI_49168	dopa	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
http://purl.obolibrary.org/obo/CHEBI_49323	contraceptive drug	http://purl.obolibrary.org/obo/CHEBI_50689	reproductive control drug		A chemical substance that prevents or reduces the probability of conception.
http://purl.obolibrary.org/obo/CHEBI_50248	hematologic agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		Drug that acts on blood and blood-forming organs and those that affect the hemostatic system.
http://purl.obolibrary.org/obo/CHEBI_50505	sweetening agent	http://purl.obolibrary.org/obo/CHEBI_35617	flavouring agent		Substance that sweeten food, beverages, medications, etc.
http://purl.obolibrary.org/obo/CHEBI_50513	mydriatic agent	http://purl.obolibrary.org/obo/CHEBI_23888	drug		Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma.
http://purl.obolibrary.org/obo/CHEBI_50584	alkyl alcohol	http://purl.obolibrary.org/obo/CHEBI_2571	aliphatic alcohol		An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position.
http://purl.obolibrary.org/obo/CHEBI_507393	taurine zwitterion	http://purl.obolibrary.org/obo/CHEBI_27369	zwitterion		The zwitterion formed from taurine by transfer of a proton from the sulfonyl to the amino group.  It is the major species existing at physiological pH.
http://purl.obolibrary.org/obo/CHEBI_52425	EC 3.2.1.18 (exo-alpha-sialidase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_36044	antiviral drug		An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.
http://purl.obolibrary.org/obo/CHEBI_57499	2-oxoadipate(2-)	http://purl.obolibrary.org/obo/CHEBI_133294	oxo dicarboxylic acid dianion		Dianion of 2-oxoadipic acid arising from deprotonation of both carboxylic acid groups.
http://purl.obolibrary.org/obo/CHEBI_57606	5-oxoprolinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		The conjugate base of 5-oxoproline.
http://purl.obolibrary.org/obo/CHEBI_57652	chondroitin D-glucuronate anion	http://purl.obolibrary.org/obo/CHEBI_61469	polyanionic polymer		Anionic form of chondroitin <small>D</small>-glucuronate arising from deprotonation of the carboxylic acid groups of the repeating units; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57726	D-proline zwitterion	http://purl.obolibrary.org/obo/CHEBI_59871	D-alpha-amino acid zwitterion		A <small>D</small>-α-amino acid zwitterion that is <small>D</small>-proline in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57742	guanidinoacetic acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_27369	zwitterion		Zwitterionic form of guanidinoacetic acid having an anionic carboxy group and a protonated guanidino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57844	L-methionine zwitterion	http://purl.obolibrary.org/obo/CHEBI_64558	methionine zwitterion		Zwitterionic form of L-methionine having a anionic carboxy group and a cationic amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57856	S-adenosyl-L-homocysteine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of <em>S</em>-adenosyl-<small>L</small>-homocysteine arising from migration of a proton from the carboxy group to the α-amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57887	tryptaminium	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		An  ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57932	D-methionine zwitterion	http://purl.obolibrary.org/obo/CHEBI_64558	methionine zwitterion		Zwitterionic form of <small>D</small>-methionine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57947	creatine zwitterion	http://purl.obolibrary.org/obo/CHEBI_27369	zwitterion		Zwitterionic form of creatine arising from transfer of a proton from the carboxy to the guanidino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57948	5-oxo-D-prolinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		The conjugate base of 5-oxo-<small>D</small>-proline; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57966	beta-alanine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of β-alanine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57977	bilirubin(2-)	http://purl.obolibrary.org/obo/CHEBI_59252	linear tetrapyrrole anion		A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_57991	biliverdin(2-)	http://purl.obolibrary.org/obo/CHEBI_59252	linear tetrapyrrole anion		Dicarboxylate anion of biliverdin; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58001	primary aliphatic ammonium ion	http://purl.obolibrary.org/obo/CHEBI_65296	primary ammonium ion		The conjugate acid of a primary aliphatic amine.
http://purl.obolibrary.org/obo/CHEBI_58954	straight-chain saturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion lacking a carbon side-chain.
http://purl.obolibrary.org/obo/CHEBI_59826	progestin	http://purl.obolibrary.org/obo/CHEBI_50745	progestogen		A synthetic progestogen.
http://purl.obolibrary.org/obo/CHEBI_59871	D-alpha-amino acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of a <small>D</small>-α-amino acid having an anionic carboxy group and a protonated amino group.
http://purl.obolibrary.org/obo/CHEBI_59876	N-acyl-D-alpha-amino acid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		The conjugate base of an <em>N</em>-acyl-<small>D</small>-α-amino acid arising from deprotonation of the C-1 carboxy group.
http://purl.obolibrary.org/obo/CHEBI_59888	gamma-aminobutyric acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of γ-aminobutyric acid having an anionic carboxy group and a protonated amino group.
http://purl.obolibrary.org/obo/CHEBI_60073	N-acylneuraminate	http://purl.obolibrary.org/obo/CHEBI_62944	sialic acid anion		A sialic acid anion arising from deprotonation of the carboxy group of an <em>N</em>-acylneuraminic acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_60084	D-glucitol 6-phosphate(2-)	http://purl.obolibrary.org/obo/CHEBI_58945	organophosphate oxoanion		Dianion of <small>D</small>-glucitol 1-phosphate arising from deprotonation of the phosphate OH groups; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_60240	divalent metal cation	http://purl.obolibrary.org/obo/CHEBI_64641	divalent inorganic cation		A metal cation with a valence of two.
http://purl.obolibrary.org/obo/CHEBI_60895	D-alpha-amino acid anion	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		Any α-amino acid anion in which the parent amino acid has <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_63070	beta-alaninate	http://purl.obolibrary.org/obo/CHEBI_49095	beta-amino-acid anion		A β-amino-acid anion that is the conjugate base of β-alanine.
http://purl.obolibrary.org/obo/CHEBI_64365	aralkylamino compound	http://purl.obolibrary.org/obo/CHEBI_50047	organic amino compound		An organic amino compound in which an aminoalkyl group is linked to an arene.
http://purl.obolibrary.org/obo/CHEBI_64558	methionine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of methionine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_64600	C21-steroid hormone	http://purl.obolibrary.org/obo/CHEBI_61313	C21-steroid		A steroid compound with a structure based on a 21-carbon (pregnane) skeleton that acts as a hormone.
http://purl.obolibrary.org/obo/CHEBI_65064	EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76871	EC 2.1.1.* (methyltransferases) inhibitor		An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of cyclopropane fatty acid synthase (EC 2.1.1.79).
http://purl.obolibrary.org/obo/CHEBI_65065	EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor	http://purl.obolibrary.org/obo/CHEBI_76871	EC 2.1.1.* (methyltransferases) inhibitor		An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of site-specific DNA-methyltransferase (adenine-specific), EC 2.1.1.72.
http://purl.obolibrary.org/obo/CHEBI_66916	alanine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of alanine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_66924	creatinate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion that is the conjugate base of creatine, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_67009	S-adenosyl-L-homocysteinate	http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion		A <small>L</small>-α-amino acid anion obtained by deprotonation of <i>S</i>-adenosyl-<small>L</small>-homocysteine.
http://purl.obolibrary.org/obo/CHEBI_70709	progesterone receptor agonist	http://purl.obolibrary.org/obo/CHEBI_51060	hormone agonist		A hormone agonist that binds to and activates progesterone receptors.
http://purl.obolibrary.org/obo/CHEBI_71598	3-oxo Delta(7)-steroid	http://purl.obolibrary.org/obo/CHEBI_47788	3-oxo steroid		Any 3-oxo steroid which also contains a double bond between positions 7 and 8.
http://purl.obolibrary.org/obo/CHEBI_72813	exopolysaccharide	http://purl.obolibrary.org/obo/CHEBI_33694	biomacromolecule		A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment.
http://purl.obolibrary.org/obo/CHEBI_74529	antidote to paracetamol poisoning	http://purl.obolibrary.org/obo/CHEBI_50247	antidote		A role borne by a molecule that acts to counteract or neutralize the deleterious effects of paracetamol (acetaminophen).
http://purl.obolibrary.org/obo/CHEBI_77119	EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76835	EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor		An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD<small><sup>+</small></sup> or NADP<small><sup>+</small></sup> acceptor) inhibitor that interferes with the action of prostaglandin-E<small><sub>2</sub></small> 9-reductase (EC 1.1.1.189).
http://purl.obolibrary.org/obo/CHEBI_77182	food colouring	http://purl.obolibrary.org/obo/CHEBI_64047	food additive		A food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199).
http://purl.obolibrary.org/obo/CHEBI_77969	food humectant	http://purl.obolibrary.org/obo/CHEBI_64047	food additive		A humectant that is used as a food additive to prevent foodstuffs from drying out.
http://purl.obolibrary.org/obo/CHEBI_78017	food propellant	http://purl.obolibrary.org/obo/CHEBI_76414	propellant		A propellant that is used to expel foods from an aerosol container.
http://purl.obolibrary.org/obo/CHEBI_78116	fatty acid anion 6:0	http://purl.obolibrary.org/obo/CHEBI_59558	medium-chain fatty acid anion		Any saturated fatty acid anion containing 6 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78295	food component	http://purl.obolibrary.org/obo/CHEBI_52211	physiological role		A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
http://purl.obolibrary.org/obo/CHEBI_78320	2-hydroxypropanoic acid	http://purl.obolibrary.org/obo/CHEBI_49302	2-hydroxy monocarboxylic acid		A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the α-hydrogens is replaced by a hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_78433	refrigerant	http://purl.obolibrary.org/obo/CHEBI_33232	application		A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
http://purl.obolibrary.org/obo/CHEBI_78444	EC 3.1.1.1 (carboxylesterase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76773	EC 3.1.1.* (carboxylic ester hydrolase) inhibitor		Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 ).
http://purl.obolibrary.org/obo/CHEBI_78616	carbohydrates and carbohydrate derivatives	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula C<small><sub><em>m</em></sub></small>(H<small><sub>2</sub></small>O)<small><sub><em>n</em></sub></small>; carbohydrate derivatives may contain other elements by substitution or condensation.
http://purl.obolibrary.org/obo/CHEBI_79387	trivalent inorganic anion	http://purl.obolibrary.org/obo/CHEBI_24834	inorganic anion		Any inorganic anion with a valency of three.
http://purl.obolibrary.org/obo/CHEBI_79389	monovalent inorganic anion	http://purl.obolibrary.org/obo/CHEBI_24834	inorganic anion		Any inorganic anion with a valency of one.
http://purl.obolibrary.org/obo/CHEBI_83038	Daphnia galeata metabolite	http://purl.obolibrary.org/obo/CHEBI_83057	Daphnia metabolite		A <em>Daphnia</em> metabolite produced by the species <em>Daphnia galeata</em>.
http://purl.obolibrary.org/obo/CHEBI_83563	long-chain alkane	http://purl.obolibrary.org/obo/CHEBI_18310	alkane		Any alkane having a chain length of at least 13 carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid	http://purl.obolibrary.org/obo/CHEBI_33709	amino acid		Any of the 23 α-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and <em>N</em>-formylmethionine. Apart from glycine, which is non-chiral, all have <small>L</small> configuration.
http://purl.obolibrary.org/obo/CHEBI_84185	D-proline derivative	http://purl.obolibrary.org/obo/CHEBI_26273	proline derivative		A non-proteinogenic amino acid derivative resulting from reaction of <small>D</small>-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of <small>D</small>-proline by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_85046	skin lightening agent	http://purl.obolibrary.org/obo/CHEBI_64857	cosmetic		Any cosmetic used to lighten the colour of skin by reducing the concentration of melanin.
http://purl.obolibrary.org/obo/CHEBI_1722	3beta-hydroxy-Delta(5)-steroid	http://purl.obolibrary.org/obo/CHEBI_36836	3beta-hydroxy steroid		Any 3β-hydroxy-steroid that contains a double bond between positions 5 and 6.
http://purl.obolibrary.org/obo/CHEBI_17964	pipecolic acid	http://purl.obolibrary.org/obo/CHEBI_26148	piperidinemonocarboxylic acid		A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.
http://purl.obolibrary.org/obo/CHEBI_20612	5-methyltetrahydrofolate	http://purl.obolibrary.org/obo/CHEBI_25345	methyltetrahydrofolate		A group of heterocyclic compounds based on the 5-methyl-5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more <small>L</small>-glutamic acid or <small>L</small>-glutamate units.
http://purl.obolibrary.org/obo/CHEBI_22605	arabinitol	http://purl.obolibrary.org/obo/CHEBI_25899	pentitol		A pentitol that is the sugar alcohol produced by the reduction of arabinose or lyxose. It is found in serum or urine of human infected with <em>Candida albicans</em>.
http://purl.obolibrary.org/obo/CHEBI_22653	asparagine	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid in which one of the hydrogens attached to the α-carbon of glycine is substituted by a 2-amino-2-oxoethyl group.
http://purl.obolibrary.org/obo/CHEBI_22695	base	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Brønsted base) or with the vacant orbital of some other molecular entity (Lewis base).
http://purl.obolibrary.org/obo/CHEBI_22959	butenoic acid	http://purl.obolibrary.org/obo/CHEBI_59202	straight-chain fatty acid		Any C<small><sub>4</sub></small>, straight-chain fatty acid containing one double bond.
http://purl.obolibrary.org/obo/CHEBI_23117	chlorine molecular entity	http://purl.obolibrary.org/obo/CHEBI_24471	halogen molecular entity		A halogen molecular entity containing one or more atoms of chlorine.
http://purl.obolibrary.org/obo/CHEBI_24281	glucosyl group	http://purl.obolibrary.org/obo/CHEBI_24403	glycosyl group		A glycosyl group obtained by removing the hydroxy group from the hemiacetal function of a glucose and, by extension, of a lower oligosaccharide having glucose at the reducing end.
http://purl.obolibrary.org/obo/CHEBI_24329	glutarate	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of glutaric acid.
http://purl.obolibrary.org/obo/CHEBI_24612	homocystines	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		A non-proteinogenic α-amino acid obtained by oxidative dimerisation of homocysteine and its derivatives.
http://purl.obolibrary.org/obo/CHEBI_24632	hydrocarbon	http://purl.obolibrary.org/obo/CHEBI_33245	organic fundamental parent		A compound consisting of carbon and hydrogen only.
http://purl.obolibrary.org/obo/CHEBI_24864	iodothyronine	http://purl.obolibrary.org/obo/CHEBI_33853	phenols		An  iodoamino acid in which the amino acid specified is  thyronine.
http://purl.obolibrary.org/obo/CHEBI_24898	isoleucine	http://purl.obolibrary.org/obo/CHEBI_38264	2-amino-3-methylpentanoic acid		A 2-amino-3-methylpentanoic acid having either (2<i>R</i>,3<i>R</i>)- or (2<i>S</i>,3<i>S</i>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_26399	purine ribonucleoside	http://purl.obolibrary.org/obo/CHEBI_18254	ribonucleoside		A ribonucleoside that has a purine moiety as the nucleobase (the R group in the illustration).
http://purl.obolibrary.org/obo/CHEBI_26739	sphingolipid	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.
http://purl.obolibrary.org/obo/CHEBI_27226	uric acid	http://purl.obolibrary.org/obo/CHEBI_25810	oxopurine		An oxopurine that is the final oxidation product of purine metabolism.
http://purl.obolibrary.org/obo/CHEBI_27247	urocanate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		An monocarboxylic acid anion that is the conjugate base of urocanic acid.
http://purl.obolibrary.org/obo/CHEBI_28159	D-asparagine	http://purl.obolibrary.org/obo/CHEBI_22653	asparagine		An optically active form of asparagine having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_28789	L-glucitol	http://purl.obolibrary.org/obo/CHEBI_30911	glucitol		The <small>L</small>-enantiomer of glucitol.
http://purl.obolibrary.org/obo/CHEBI_30660	thyroxine	http://purl.obolibrary.org/obo/CHEBI_24864	iodothyronine		An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.
http://purl.obolibrary.org/obo/CHEBI_30861	methylmalonate(1-)	http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion		A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of methylmalonic acid.
http://purl.obolibrary.org/obo/CHEBI_32442	L-cysteinate(1-)	http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion		The <small>L</small>-enantiomer of cysteinate(1−).
http://purl.obolibrary.org/obo/CHEBI_32445	L-cysteinium	http://purl.obolibrary.org/obo/CHEBI_32458	cysteinium		The <small>L</small>-enantiomer of cysteinium.
http://purl.obolibrary.org/obo/CHEBI_32650	L-asparaginate	http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion		An optically active form of asparaginate having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_32784	tyrosinate(1-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of tyrosine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32786	tyrosinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of tyrosine, arising from protonation of the amino group.
http://purl.obolibrary.org/obo/CHEBI_32796	(R)-2-hydroxyglutaric acid	http://purl.obolibrary.org/obo/CHEBI_17084	2-hydroxyglutaric acid		The (<i>R</i>)-enantiomer of 2-hydroxyglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_32845	serinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of serine.
http://purl.obolibrary.org/obo/CHEBI_32846	serinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of serine.
http://purl.obolibrary.org/obo/CHEBI_32862	L-prolinate	http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion		An optically active form of prolinate having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_32864	L-prolinium	http://purl.obolibrary.org/obo/CHEBI_32872	prolinium		An optically active form of prolinium having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_33019	diphosphate(3-)	http://purl.obolibrary.org/obo/CHEBI_79387	trivalent inorganic anion		A trivalent inorganic anion obtained by removal of all three protons from diphosphoric acid.
http://purl.obolibrary.org/obo/CHEBI_33292	fuel	http://purl.obolibrary.org/obo/CHEBI_33232	application		An energy-rich substance that can be transformed with release of usable energy.
http://purl.obolibrary.org/obo/CHEBI_33569	noradrenaline	http://purl.obolibrary.org/obo/CHEBI_33567	catecholamine		A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted.
http://purl.obolibrary.org/obo/CHEBI_33653	aliphatic compound	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds.
http://purl.obolibrary.org/obo/CHEBI_33694	biomacromolecule	http://purl.obolibrary.org/obo/CHEBI_33839	macromolecule		A macromolecule formed by a living organism.
http://purl.obolibrary.org/obo/CHEBI_33917	aldohexose	http://purl.obolibrary.org/obo/CHEBI_18133	hexose		A hexose with a (potential) aldehyde group at one end.
http://purl.obolibrary.org/obo/CHEBI_33984	fucose	http://purl.obolibrary.org/obo/CHEBI_18133	hexose		Any deoxygalactose that is deoxygenated at the 6-position.
http://purl.obolibrary.org/obo/CHEBI_35243	serine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of serine.
http://purl.obolibrary.org/obo/CHEBI_35492	cystine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion that is the tautomer of cystine.
http://purl.obolibrary.org/obo/CHEBI_35569	alpha-adrenergic agonist	http://purl.obolibrary.org/obo/CHEBI_48539	alpha-adrenergic drug		An agent that selectively binds to and activates α-adrenergic receptors.
http://purl.obolibrary.org/obo/CHEBI_35584	purine	http://purl.obolibrary.org/obo/CHEBI_35570	mancude organic heterobicyclic parent		A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines.
http://purl.obolibrary.org/obo/CHEBI_35586	1H-purine	http://purl.obolibrary.org/obo/CHEBI_35584	purine		The 1<em>H</em>-tautomer of purine.
http://purl.obolibrary.org/obo/CHEBI_35588	3H-purine	http://purl.obolibrary.org/obo/CHEBI_35584	purine		The 3<em>H</em>-tautomer of purine.
http://purl.obolibrary.org/obo/CHEBI_35604	carbon oxoanion	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula C<small><sub><em>x</em></sub></small>O<small><sub><em>y</em></sub></small><small><sup><em>n</em>−</small></sup> for some integers <em>x</em>, <em>y</em> and <em>n</em>.
http://purl.obolibrary.org/obo/CHEBI_356416	5-ammoniolevulinate	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		The zwitterion formed from 5-aminolevulinic acid by transfer of a proton from the carboxy group to the amino group.  It is the major species present at physiological pH.
http://purl.obolibrary.org/obo/CHEBI_35741	glycerolipid	http://purl.obolibrary.org/obo/CHEBI_18059	lipid		Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.
http://purl.obolibrary.org/obo/CHEBI_35780	phosphate ion	http://purl.obolibrary.org/obo/CHEBI_33461	phosphorus oxoanion		A phosphorus oxoanion that is the conjugate base of phosphoric acid.
http://purl.obolibrary.org/obo/CHEBI_27612	hydantoin	http://purl.obolibrary.org/obo/CHEBI_24628	imidazolidine-2,4-dione		
http://purl.obolibrary.org/obo/CHEBI_22881	biopterins	http://purl.obolibrary.org/obo/CHEBI_26375	pterins		
http://purl.obolibrary.org/obo/CHEBI_25500	neopterins	http://purl.obolibrary.org/obo/CHEBI_26375	pterins		
http://purl.obolibrary.org/obo/CHEBI_35570	mancude organic heterobicyclic parent	http://purl.obolibrary.org/obo/CHEBI_35571	mancude organic heterocyclic parent		
http://purl.obolibrary.org/obo/CHEBI_47880	steroid ester	http://purl.obolibrary.org/obo/CHEBI_35701	ester		
http://purl.obolibrary.org/obo/CHEBI_36078	cholanoid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		
http://purl.obolibrary.org/obo/CHEBI_26151	piperidines	http://purl.obolibrary.org/obo/CHEBI_25693	organic heteromonocyclic compound		
http://purl.obolibrary.org/obo/CHEBI_46767	pyrrolidinecarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_26456	pyrrolidine alkaloid	http://purl.obolibrary.org/obo/CHEBI_22315	alkaloid		
http://purl.obolibrary.org/obo/CHEBI_23230	chromanes	http://purl.obolibrary.org/obo/CHEBI_38443	1-benzopyran		
http://purl.obolibrary.org/obo/CHEBI_32797	(S)-2-hydroxyglutaric acid	http://purl.obolibrary.org/obo/CHEBI_17084	2-hydroxyglutaric acid		
http://purl.obolibrary.org/obo/CHEBI_36147	oxo dicarboxylate	http://purl.obolibrary.org/obo/CHEBI_28965	dicarboxylic acid dianion		
http://purl.obolibrary.org/obo/CHEBI_76283	sebacate(2-)	http://purl.obolibrary.org/obo/CHEBI_132954	sebacate		
http://purl.obolibrary.org/obo/CHEBI_35740	liposaccharide	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		
http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		
http://purl.obolibrary.org/obo/CHEBI_24961	ketoaldonate	http://purl.obolibrary.org/obo/CHEBI_33721	carbohydrate acid anion		
http://purl.obolibrary.org/obo/CHEBI_35237	cysteine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		
http://purl.obolibrary.org/obo/CHEBI_132943	aspartate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_27092	tricarboxylic acid trianion	http://purl.obolibrary.org/obo/CHEBI_38717	carboxylic acid trianion		
http://purl.obolibrary.org/obo/CHEBI_36818	seco-cholestane	http://purl.obolibrary.org/obo/CHEBI_35788	seco-steroid		
http://purl.obolibrary.org/obo/CHEBI_35974	4-oxo monocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_35902	oxo monocarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_21836	N(4)-glycosyl-L-asparagine	http://purl.obolibrary.org/obo/CHEBI_83822	non-proteinogenic L-alpha-amino acid		
http://purl.obolibrary.org/obo/CHEBI_22506	aminoglycan	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		
http://purl.obolibrary.org/obo/CHEBI_47910	S-substituted L-cysteine	http://purl.obolibrary.org/obo/CHEBI_26834	sulfur-containing amino acid		
http://purl.obolibrary.org/obo/CHEBI_24439	guanidinoacetic acids	http://purl.obolibrary.org/obo/CHEBI_24373	glycine derivative		
http://purl.obolibrary.org/obo/CHEBI_24582	hexitol phosphate	http://purl.obolibrary.org/obo/CHEBI_63430	hexitol derivative		
http://purl.obolibrary.org/obo/CHEBI_35375	alditol 6-phosphate	http://purl.obolibrary.org/obo/CHEBI_22297	alditol phosphate		
http://purl.obolibrary.org/obo/CHEBI_22485	glucosamine oligosaccharide	http://purl.obolibrary.org/obo/CHEBI_22483	amino oligosaccharide		
http://purl.obolibrary.org/obo/CHEBI_22484	galactosamine oligosaccharide	http://purl.obolibrary.org/obo/CHEBI_22483	amino oligosaccharide		
http://purl.obolibrary.org/obo/CHEBI_35155	elemental calcium	http://purl.obolibrary.org/obo/CHEBI_22985	calcium molecular entity		
http://purl.obolibrary.org/obo/CHEBI_35163	cyclic carotene	http://purl.obolibrary.org/obo/CHEBI_23042	carotene		
http://purl.obolibrary.org/obo/CHEBI_23341	cobamides	http://purl.obolibrary.org/obo/CHEBI_23390	cobalt-corrinoid hexaamide		
http://purl.obolibrary.org/obo/CHEBI_33429	monoatomic monoanion	http://purl.obolibrary.org/obo/CHEBI_36830	monoanion		
http://purl.obolibrary.org/obo/CHEBI_25414	monoatomic monocation	http://purl.obolibrary.org/obo/CHEBI_23906	monoatomic cation		
http://purl.obolibrary.org/obo/CHEBI_30412	monoatomic dication	http://purl.obolibrary.org/obo/CHEBI_23906	monoatomic cation		
http://purl.obolibrary.org/obo/CHEBI_35721	heparan sulfates	http://purl.obolibrary.org/obo/CHEBI_35722	sulfated glycosaminoglycan		
http://purl.obolibrary.org/obo/CHEBI_33461	phosphorus oxoanion	http://purl.obolibrary.org/obo/CHEBI_33459	pnictogen oxoanion		
http://purl.obolibrary.org/obo/CHEBI_24836	inorganic oxide	http://purl.obolibrary.org/obo/CHEBI_25741	oxide		
http://purl.obolibrary.org/obo/CHEBI_24868	organic salt	http://purl.obolibrary.org/obo/CHEBI_24866	salt		
http://purl.obolibrary.org/obo/CHEBI_35479	alkali metal salt	http://purl.obolibrary.org/obo/CHEBI_33296	alkali metal molecular entity		
http://purl.obolibrary.org/obo/CHEBI_22869	bilins	http://purl.obolibrary.org/obo/CHEBI_25046	linear tetrapyrrole		
http://purl.obolibrary.org/obo/CHEBI_33504	alkali metal cation	http://purl.obolibrary.org/obo/CHEBI_25213	metal cation		
http://purl.obolibrary.org/obo/CHEBI_23014	carbon oxide	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		
http://purl.obolibrary.org/obo/CHEBI_25703	organic phosphate	http://purl.obolibrary.org/obo/CHEBI_26079	phosphoric acid derivative		
http://purl.obolibrary.org/obo/CHEBI_26361	protoporphyrins	http://purl.obolibrary.org/obo/CHEBI_26214	porphyrins		
http://purl.obolibrary.org/obo/CHEBI_37247	elemental potassium	http://purl.obolibrary.org/obo/CHEBI_26217	potassium molecular entity		
http://purl.obolibrary.org/obo/CHEBI_26284	propane-1,2-diols	http://purl.obolibrary.org/obo/CHEBI_26288	propanediol		
http://purl.obolibrary.org/obo/CHEBI_37246	elemental sodium	http://purl.obolibrary.org/obo/CHEBI_26712	sodium molecular entity		
http://purl.obolibrary.org/obo/CHEBI_38700	organic sodium salt	http://purl.obolibrary.org/obo/CHEBI_24868	organic salt		
http://purl.obolibrary.org/obo/CHEBI_23045	carotenol	http://purl.obolibrary.org/obo/CHEBI_27325	xanthophyll		
http://purl.obolibrary.org/obo/CHEBI_32651	L-asparaginium	http://purl.obolibrary.org/obo/CHEBI_32661	asparaginium		
http://purl.obolibrary.org/obo/CHEBI_36902	chalcogen hydride	http://purl.obolibrary.org/obo/CHEBI_33242	inorganic hydride		
http://purl.obolibrary.org/obo/CHEBI_26835	sulfur molecular entity	http://purl.obolibrary.org/obo/CHEBI_33304	chalcogen molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33836	benzenoid aromatic compound	http://purl.obolibrary.org/obo/CHEBI_33659	organic aromatic compound		
http://purl.obolibrary.org/obo/CHEBI_23377	copper molecular entity	http://purl.obolibrary.org/obo/CHEBI_33745	copper group molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33659	organic aromatic compound	http://purl.obolibrary.org/obo/CHEBI_33655	aromatic compound		
http://purl.obolibrary.org/obo/CHEBI_35344	21-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_35350	hydroxy steroid		
http://purl.obolibrary.org/obo/CHEBI_35722	sulfated glycosaminoglycan	http://purl.obolibrary.org/obo/CHEBI_18085	glycosaminoglycan		
http://purl.obolibrary.org/obo/CHEBI_26079	phosphoric acid derivative	http://purl.obolibrary.org/obo/CHEBI_36359	phosphorus oxoacid derivative		
http://purl.obolibrary.org/obo/CHEBI_36961	chalcocarbonic acid	http://purl.obolibrary.org/obo/CHEBI_36962	organochalcogen compound		
http://purl.obolibrary.org/obo/CHEBI_25355	mitochondrial respiratory-chain inhibitor	http://purl.obolibrary.org/obo/CHEBI_38497	respiratory-chain inhibitor		
http://purl.obolibrary.org/obo/CHEBI_50326	sulfanylmethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50340	3-carbamimidamidopropyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_24712	hydroxymethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_35106	nitrogen hydride	http://purl.obolibrary.org/obo/CHEBI_35881	pnictogen hydride		
http://purl.obolibrary.org/obo/CHEBI_39123	calcium cation	http://purl.obolibrary.org/obo/CHEBI_33513	alkaline earth cation		
http://purl.obolibrary.org/obo/HP_0002113	Pulmonary infiltrates	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		
http://purl.obolibrary.org/obo/HP_0002344	Progressive neurologic deterioration	http://purl.obolibrary.org/obo/HP_0001268	Mental deterioration		
http://purl.obolibrary.org/obo/HP_0002651	Spondyloepimetaphyseal dysplasia	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		
http://purl.obolibrary.org/obo/HP_0002093	Respiratory insufficiency	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		
http://purl.obolibrary.org/obo/HP_0002503	Spinocerebellar tract degeneration	http://purl.obolibrary.org/obo/HP_0003133	Abnormal spinocerebellar tract morphology		
http://purl.obolibrary.org/obo/HP_0007313	Cerebral degeneration	http://purl.obolibrary.org/obo/HP_0007369	Atrophy/Degeneration affecting the cerebrum		
http://purl.obolibrary.org/obo/HP_0001944	Dehydration	http://purl.obolibrary.org/obo/HP_0011032	Abnormality of fluid regulation		
http://purl.obolibrary.org/obo/HP_0004308	Ventricular arrhythmia	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		
http://purl.obolibrary.org/obo/HP_0035013	Abnormal extrahepatic bile duct morphology	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		
http://purl.obolibrary.org/obo/HP_0003003	Colon cancer	http://purl.obolibrary.org/obo/HP_0100273	Neoplasm of the colon		
http://purl.obolibrary.org/obo/CHEBI_19255	pyrimidine 2'-deoxyribonucleoside	http://purl.obolibrary.org/obo/CHEBI_68472	pyrimidine deoxyribonucleoside		
http://purl.obolibrary.org/obo/CHEBI_12109	5-aminolevulinate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_36109	piperidinecarboxylate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_25147	mandelate	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_48376	carbamimidic acid	http://purl.obolibrary.org/obo/CHEBI_48379	isourea		
http://purl.obolibrary.org/obo/CHEBI_23981	ethanolamines	http://purl.obolibrary.org/obo/CHEBI_22478	amino alcohol		
http://purl.obolibrary.org/obo/CHEBI_33720	carbohydrate acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_29057	keratan	http://purl.obolibrary.org/obo/CHEBI_18085	glycosaminoglycan		
http://purl.obolibrary.org/obo/CHEBI_25274	methylamines	http://purl.obolibrary.org/obo/CHEBI_22331	alkylamines		
http://purl.obolibrary.org/obo/CHEBI_22494	aminobenzoate	http://purl.obolibrary.org/obo/CHEBI_22718	benzoates		
http://purl.obolibrary.org/obo/CHEBI_48154	sulfur oxide	http://purl.obolibrary.org/obo/CHEBI_26835	sulfur molecular entity		
http://purl.obolibrary.org/obo/CHEBI_23366	compatible osmolytes	http://purl.obolibrary.org/obo/CHEBI_25728	osmolyte		
http://purl.obolibrary.org/obo/CHEBI_26338	prostaglandins E	http://purl.obolibrary.org/obo/CHEBI_3992	cyclic ketone		
http://purl.obolibrary.org/obo/CHEBI_30488	sulfonium	http://purl.obolibrary.org/obo/CHEBI_33535	sulfur hydride		
http://purl.obolibrary.org/obo/CHEBI_29989	D-glutamate(2-)	http://purl.obolibrary.org/obo/CHEBI_29987	glutamate(2-)		
http://purl.obolibrary.org/obo/CHEBI_35782	diphosphate ion	http://purl.obolibrary.org/obo/CHEBI_33461	phosphorus oxoanion		
http://purl.obolibrary.org/obo/CHEBI_29793	hydridodioxygen(1+)	http://purl.obolibrary.org/obo/CHEBI_33693	oxygen hydride		
http://purl.obolibrary.org/obo/CHEBI_26834	sulfur-containing amino acid	http://purl.obolibrary.org/obo/CHEBI_33576	sulfur-containing carboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_35258	glyco-amino acid	http://purl.obolibrary.org/obo/CHEBI_63299	carbohydrate derivative		
http://purl.obolibrary.org/obo/CHEBI_32458	cysteinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_32696	argininium(1+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_26394	purine nucleoside	http://purl.obolibrary.org/obo/CHEBI_26401	purines		
http://purl.obolibrary.org/obo/CHEBI_26440	pyrimidine nucleoside	http://purl.obolibrary.org/obo/CHEBI_39447	pyrimidines		
http://purl.obolibrary.org/obo/CHEBI_48937	phytane	http://purl.obolibrary.org/obo/CHEBI_35190	diterpene		
http://purl.obolibrary.org/obo/CHEBI_35236	D-cysteine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35237	cysteine zwitterion		
http://purl.obolibrary.org/obo/CHEBI_35235	L-cysteine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35237	cysteine zwitterion		
http://purl.obolibrary.org/obo/CHEBI_30795	malonate(1-)	http://purl.obolibrary.org/obo/CHEBI_35695	dicarboxylic acid monoanion		
http://purl.obolibrary.org/obo/CHEBI_38560	simple protein	http://purl.obolibrary.org/obo/CHEBI_36080	protein		
http://purl.obolibrary.org/obo/CHEBI_13941	carbamate	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_26816	carbohydrate phosphate	http://purl.obolibrary.org/obo/CHEBI_37734	phosphoric ester		
http://purl.obolibrary.org/obo/CHEBI_29922	sulfo group	http://purl.obolibrary.org/obo/CHEBI_33246	inorganic group		
http://purl.obolibrary.org/obo/CHEBI_46629	oxo group	http://purl.obolibrary.org/obo/CHEBI_33246	inorganic group		
http://purl.obolibrary.org/obo/CHEBI_29337	azanide	http://purl.obolibrary.org/obo/CHEBI_79389	monovalent inorganic anion		
http://purl.obolibrary.org/obo/CHEBI_33693	oxygen hydride	http://purl.obolibrary.org/obo/CHEBI_36902	chalcogen hydride		
http://purl.obolibrary.org/obo/CHEBI_33535	sulfur hydride	http://purl.obolibrary.org/obo/CHEBI_26835	sulfur molecular entity		
http://purl.obolibrary.org/obo/CHEBI_28976	carbonic acid	http://purl.obolibrary.org/obo/CHEBI_35605	carbon oxoacid		
http://purl.obolibrary.org/obo/CHEBI_29105	zinc(2+)	http://purl.obolibrary.org/obo/CHEBI_60240	divalent metal cation		
http://purl.obolibrary.org/obo/CL_0000357	stratified epithelial stem cell	http://purl.obolibrary.org/obo/CL_0000036	epithelial fate stem cell		
http://purl.obolibrary.org/obo/CL_0000354	blastemal cell	http://purl.obolibrary.org/obo/CL_0000048	multi fate stem cell		
http://purl.obolibrary.org/obo/CL_0000069	branched duct epithelial cell	http://purl.obolibrary.org/obo/CL_0000068	duct epithelial cell		
http://purl.obolibrary.org/obo/CL_0000072	non-branched duct epithelial cell	http://purl.obolibrary.org/obo/CL_0002078	meso-epithelial cell		
http://purl.obolibrary.org/obo/CL_0000377	tracheoblast	http://purl.obolibrary.org/obo/CL_0000069	branched duct epithelial cell		
http://purl.obolibrary.org/obo/CL_0000146	simple columnar epithelial cell	http://purl.obolibrary.org/obo/CL_0000075	columnar/cuboidal epithelial cell		
http://purl.obolibrary.org/obo/CL_0000237	keratinizing barrier epithelial cell	http://purl.obolibrary.org/obo/CL_0002077	ecto-epithelial cell		
http://purl.obolibrary.org/obo/CL_0000123	neuron associated cell (sensu Vertebrata)	http://purl.obolibrary.org/obo/CL_0000095	neuron associated cell		
http://purl.obolibrary.org/obo/CL_0000149	visual pigment cell	http://purl.obolibrary.org/obo/CL_0000147	pigment cell		
http://purl.obolibrary.org/obo/CL_0000159	seromucus secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		
http://purl.obolibrary.org/obo/CL_0000314	milk secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		
http://purl.obolibrary.org/obo/CL_0000447	carbohydrate secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		
http://purl.obolibrary.org/obo/CL_0000457	biogenic amine secreting cell	http://purl.obolibrary.org/obo/CL_0000151	secretory cell		
http://purl.obolibrary.org/obo/CL_0000306	crystallin accumulating cell	http://purl.obolibrary.org/obo/CL_0000325	stuff accumulating cell		
http://purl.obolibrary.org/obo/CL_0000311	keratin accumulating cell	http://purl.obolibrary.org/obo/CL_0000325	stuff accumulating cell		
http://purl.obolibrary.org/obo/CL_0000417	endopolyploid cell	http://purl.obolibrary.org/obo/CL_0000412	polyploid cell		
http://purl.obolibrary.org/obo/CL_0000327	extracellular matrix secreting cell	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		
http://purl.obolibrary.org/obo/CL_0001019	CD115-positive monocyte OR common dendritic progenitor	http://purl.obolibrary.org/obo/CL_0002031	hematopoietic lineage restricted progenitor cell		
http://purl.obolibrary.org/obo/CL_0000995	CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		
http://purl.obolibrary.org/obo/CL_0001012	CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		
http://purl.obolibrary.org/obo/CL_0001030	CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		
http://purl.obolibrary.org/obo/CL_0000095	neuron associated cell	http://purl.obolibrary.org/obo/CL_0002319	neural cell		
http://purl.obolibrary.org/obo/CL_1001064	kidney artery smooth muscle cell	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		
http://purl.obolibrary.org/obo/CL_1001066	kidney arteriole smooth muscle cell	http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell		
http://purl.obolibrary.org/obo/UBERON_0035307	branch of vertebral artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0035398	branch of external carotid artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0035489	branch of basilar artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0035131	auditory ossicle cartilage element	http://purl.obolibrary.org/obo/UBERON_0011004	pharyngeal arch cartilage		
http://purl.obolibrary.org/obo/UBERON_0035132	auditory ossicle pre-cartilage element	http://purl.obolibrary.org/obo/UBERON_0035130	auditory ossicle endochondral element		
http://purl.obolibrary.org/obo/HP_0031687	Abnormally loud pulmonic component of the second heart sound	http://purl.obolibrary.org/obo/HP_0031661	Abnormal second heart sound		
http://purl.obolibrary.org/obo/CHEBI_23449	cyclic peptide	http://purl.obolibrary.org/obo/CHEBI_16670	peptide		
http://purl.obolibrary.org/obo/CHEBI_3992	cyclic ketone	http://purl.obolibrary.org/obo/CHEBI_17087	ketone		
http://purl.obolibrary.org/obo/CHEBI_35269	N-glycosyl amino acid	http://purl.obolibrary.org/obo/CHEBI_35258	glyco-amino acid		
http://purl.obolibrary.org/obo/CHEBI_21622	N-acetylneuraminic acids	http://purl.obolibrary.org/obo/CHEBI_16498	N-acylneuraminic acid		
http://purl.obolibrary.org/obo/CHEBI_27547	zeaxanthin	http://purl.obolibrary.org/obo/CHEBI_23045	carotenol		
http://purl.obolibrary.org/obo/CHEBI_38631	aminoalkylindole	http://purl.obolibrary.org/obo/CHEBI_24828	indoles		
http://purl.obolibrary.org/obo/CHEBI_26447	pyrimidinemonocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_78574	pyrimidinecarboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_35147	(6'R)-beta,epsilon-carotene	http://purl.obolibrary.org/obo/CHEBI_28425	alpha-carotene		
http://purl.obolibrary.org/obo/CHEBI_17062	primary aliphatic amine	http://purl.obolibrary.org/obo/CHEBI_32877	primary amine		
http://purl.obolibrary.org/obo/CHEBI_32695	argininate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_38179	monocyclic heteroarene	http://purl.obolibrary.org/obo/CHEBI_33833	heteroarene		
http://purl.obolibrary.org/obo/CHEBI_88539	Pyridinoline	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		
http://purl.obolibrary.org/obo/CHEBI_35950	4-oxo monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35871	oxo monocarboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_16733	D-alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		
http://purl.obolibrary.org/obo/CHEBI_24610	homocysteines	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		
http://purl.obolibrary.org/obo/CHEBI_23324	citrullines	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		
http://purl.obolibrary.org/obo/CHEBI_28383	alpha,omega-dicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		
http://purl.obolibrary.org/obo/CHEBI_24583	hexitol	http://purl.obolibrary.org/obo/CHEBI_17522	alditol		
http://purl.obolibrary.org/obo/CHEBI_140785	R-cob(III)alamin	http://purl.obolibrary.org/obo/CHEBI_23333	cob(III)alamins		
http://purl.obolibrary.org/obo/CHEBI_23334	cobalamins	http://purl.obolibrary.org/obo/CHEBI_176843	vitamin B12		
http://purl.obolibrary.org/obo/CHEBI_26725	glucitol phosphate	http://purl.obolibrary.org/obo/CHEBI_24582	hexitol phosphate		
http://purl.obolibrary.org/obo/CHEBI_30911	glucitol	http://purl.obolibrary.org/obo/CHEBI_24583	hexitol		
http://purl.obolibrary.org/obo/CHEBI_23505	cystathionines	http://purl.obolibrary.org/obo/CHEBI_24610	homocysteines		
http://purl.obolibrary.org/obo/CHEBI_23641	deoxyuridine phosphate	http://purl.obolibrary.org/obo/CHEBI_25608	nucleoside phosphate		
http://purl.obolibrary.org/obo/CHEBI_21968	O-phosphoamino acid	http://purl.obolibrary.org/obo/CHEBI_26051	phosphoamino acid		
http://purl.obolibrary.org/obo/CHEBI_36711	phosphoethanolamine	http://purl.obolibrary.org/obo/CHEBI_37734	phosphoric ester		
http://purl.obolibrary.org/obo/CHEBI_37734	phosphoric ester	http://purl.obolibrary.org/obo/CHEBI_35701	ester		
http://purl.obolibrary.org/obo/CHEBI_18420	magnesium(2+)	http://purl.obolibrary.org/obo/CHEBI_39127	magnesium cation		
http://purl.obolibrary.org/obo/CHEBI_47857	ureas	http://purl.obolibrary.org/obo/CHEBI_33256	primary amide		
http://purl.obolibrary.org/obo/CHEBI_29214	sulfonic acid	http://purl.obolibrary.org/obo/CHEBI_33402	sulfur oxoacid		
http://purl.obolibrary.org/obo/CHEBI_33540	thiosulfuric acid	http://purl.obolibrary.org/obo/CHEBI_33402	sulfur oxoacid		
http://purl.obolibrary.org/obo/CHEBI_48854	sulfurous acid	http://purl.obolibrary.org/obo/CHEBI_33402	sulfur oxoacid		
http://purl.obolibrary.org/obo/CHEBI_18140	hydrogen halide	http://purl.obolibrary.org/obo/CHEBI_33405	hydracid		
http://purl.obolibrary.org/obo/CHEBI_17137	hydrogensulfite	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		
http://purl.obolibrary.org/obo/CHEBI_33541	thiosulfate(1-)	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		
http://purl.obolibrary.org/obo/CHEBI_45696	hydrogensulfate	http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion		
http://purl.obolibrary.org/obo/CHEBI_29919	hydrosulfide	http://purl.obolibrary.org/obo/CHEBI_33535	sulfur hydride		
http://purl.obolibrary.org/obo/CHEBI_48355	non-polar solvent	http://purl.obolibrary.org/obo/CHEBI_46787	solvent		
http://purl.obolibrary.org/obo/CHEBI_23333	cob(III)alamins	http://purl.obolibrary.org/obo/CHEBI_23334	cobalamins		
http://purl.obolibrary.org/obo/CHEBI_26830	sulfonium compound	http://purl.obolibrary.org/obo/CHEBI_26835	sulfur molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33402	sulfur oxoacid	http://purl.obolibrary.org/obo/CHEBI_33484	chalcogen oxoacid		
http://purl.obolibrary.org/obo/CHEBI_33482	sulfur oxoanion	http://purl.obolibrary.org/obo/CHEBI_33485	chalcogen oxoanion		
http://purl.obolibrary.org/obo/CHEBI_18291	manganese atom	http://purl.obolibrary.org/obo/CHEBI_33352	manganese group element atom		
http://purl.obolibrary.org/obo/CHEBI_33695	information biomacromolecule	http://purl.obolibrary.org/obo/CHEBI_33694	biomacromolecule		
http://purl.obolibrary.org/obo/CHEBI_26051	phosphoamino acid	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		
http://purl.obolibrary.org/obo/CHEBI_33263	diatomic oxygen	http://purl.obolibrary.org/obo/CHEBI_33262	elemental oxygen		
http://purl.obolibrary.org/obo/CHEBI_33432	monoatomic chlorine	http://purl.obolibrary.org/obo/CHEBI_33433	monoatomic halogen		
http://purl.obolibrary.org/obo/CHEBI_33352	manganese group element atom	http://purl.obolibrary.org/obo/CHEBI_27081	transition element atom		
http://purl.obolibrary.org/obo/CHEBI_33356	iron group element atom	http://purl.obolibrary.org/obo/CHEBI_27081	transition element atom		
http://purl.obolibrary.org/obo/CHEBI_33842	aromatic annulene	http://purl.obolibrary.org/obo/CHEBI_33847	monocyclic arene		
http://purl.obolibrary.org/obo/CHEBI_37176	mononuclear parent hydride	http://purl.obolibrary.org/obo/CHEBI_33692	hydrides		
http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation	http://purl.obolibrary.org/obo/CHEBI_33703	amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_33700	proteinogenic amino-acid residue	http://purl.obolibrary.org/obo/CHEBI_33710	alpha-amino-acid residue		
http://purl.obolibrary.org/obo/CHEBI_33890	cobalt coordination entity	http://purl.obolibrary.org/obo/CHEBI_33888	cobalt molecular entity		
http://purl.obolibrary.org/obo/HP_0040331	Focal hypointensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0007103	Hypointensity of cerebral white matter on MRI		
http://purl.obolibrary.org/obo/HP_0040332	Multifocal hypointensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0007103	Hypointensity of cerebral white matter on MRI		
http://purl.obolibrary.org/obo/HP_0040333	Confluent hypointensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0007204	Diffuse white matter abnormalities		
http://purl.obolibrary.org/obo/UBERON_0035651	glans	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		
http://purl.obolibrary.org/obo/UBERON_0036301	vasculature of spleen	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		
http://purl.obolibrary.org/obo/UBERON_0035096	fascia of tail	http://purl.obolibrary.org/obo/UBERON_0008982	fascia		
http://purl.obolibrary.org/obo/UBERON_0034994	hindbrain cortical intermediate zone	http://purl.obolibrary.org/obo/UBERON_0004040	cortical intermediate zone		
http://purl.obolibrary.org/obo/UBERON_0035130	auditory ossicle endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		
http://purl.obolibrary.org/obo/CHEBI_30848	urate(1-)	http://purl.obolibrary.org/obo/CHEBI_46818	urate anion		
http://purl.obolibrary.org/obo/CHEBI_37786	acyclic phosphorus acid anhydride	http://purl.obolibrary.org/obo/CHEBI_36608	acyclic acid anhydride		
http://purl.obolibrary.org/obo/HP_0020044	Horizontal incomitant strabismus	http://purl.obolibrary.org/obo/HP_0025068	Incomitant strabismus		
http://purl.obolibrary.org/obo/MPATH_1000	pathological phenotype observation				Phenotypic observation of the presence or absence of a pathological entity.
http://purl.obolibrary.org/obo/HP_6000523	obsolete Increased urinary bile acid level				The amount of bile acids in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/CHEBI_24431	chemical entity				A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
http://purl.obolibrary.org/obo/CHEBI_50906	role				A role is particular behaviour which a material entity may exhibit.
http://purl.obolibrary.org/obo/PATO_0000001	quality				A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities
http://purl.obolibrary.org/obo/HP_0031533	obsolete Multifocal sub-RPE deposits				Deposits accumulating between the retinal pigment epithelium and Bruch's membrane and that are distributed in multiple foci.
http://purl.obolibrary.org/obo/HP_0031698	obsolete Disseminated Bacillus Calmette-Guerin infection				Failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.
http://purl.obolibrary.org/obo/HP_0040316	obsolete Aplasia of the penis				
http://purl.obolibrary.org/obo/HP_6000543	obsolete Positive mycobacterium CSF culture				
http://purl.obolibrary.org/obo/HP_0030332	obsolete Abnormal T cell morphology				
http://purl.obolibrary.org/obo/HP_0040048	obsolete Aplasia of the left hemidiaphragm				
http://purl.obolibrary.org/obo/HP_0031988	obsolete Muscle spasm				
http://purl.obolibrary.org/obo/HP_0031362	obsolete Sex-limited autosomal recessive inheritance				
http://purl.obolibrary.org/obo/HP_0031297	obsolete Coronary sinus atrial septal defect				
http://purl.obolibrary.org/obo/HP_0031349	obsolete Levotransposition of the great arteries				
http://purl.obolibrary.org/obo/HP_0031529	obsolete Focal subretinal deposits				
http://purl.obolibrary.org/obo/HP_0031530	obsolete Multifocal subretinal deposits				
http://purl.obolibrary.org/obo/HP_0031532	obsolete Focal sub-RPE deposits				
http://purl.obolibrary.org/obo/HP_0033455	obsolete Elevated urinary dicarboxylic acid level				
http://purl.obolibrary.org/obo/HP_0033798	obsolete Impaired leukocyte adhesion				
http://purl.obolibrary.org/obo/HP_0034826	obsolete Triggered by medication exposure				
http://purl.obolibrary.org/obo/HP_0034933	obsolete Increased circulating ribitol concentration				
http://purl.obolibrary.org/obo/HP_0034994	obsolete Elevated circulating saccharopine concentration				
http://purl.obolibrary.org/obo/HP_6000117	obsolete Elevated urinary AICA-riboside level				
http://purl.obolibrary.org/obo/HP_6000159	obsolete Hepatic lipid-laden macrophage infiltration				
http://purl.obolibrary.org/obo/HP_0000001	All				
http://purl.obolibrary.org/obo/HP_0000057	obsolete Clitoromegaly				
http://purl.obolibrary.org/obo/HP_0000284	obsolete Abnormality of the ocular region				
http://purl.obolibrary.org/obo/HP_0000361	obsolete Pulsatile tinnitus (tympanic paraganglioma)				
http://purl.obolibrary.org/obo/HP_0000368	obsolete Low-set, posteriorly rotated ears				
http://purl.obolibrary.org/obo/HP_0000487	obsolete Congenital strabismus				
http://purl.obolibrary.org/obo/HP_0000535	obsolete Sparse and thin eyebrow				
http://purl.obolibrary.org/obo/HP_0000547	obsolete Tapetoretinal degeneration				
http://purl.obolibrary.org/obo/HP_0000611	obsolete Choroid coloboma				
http://purl.obolibrary.org/obo/HP_0000655	obsolete Vitreoretinal degeneration				
http://purl.obolibrary.org/obo/HP_0000720	obsolete Mood swings				
http://purl.obolibrary.org/obo/HP_0000735	obsolete Impaired social interactions				
http://purl.obolibrary.org/obo/HP_0000833	obsolete Glucose intolerance				
http://purl.obolibrary.org/obo/HP_0000923	obsolete Beaded ribs				
http://purl.obolibrary.org/obo/HP_0000976	obsolete Eczematoid dermatitis				
http://purl.obolibrary.org/obo/HP_0001002	obsolete Decreased subcutaneous fat				
http://purl.obolibrary.org/obo/HP_0001006	obsolete Hypotrichosis				
http://purl.obolibrary.org/obo/HP_0001011	obsolete Diaphoresis (with pheochromocytoma)				
http://purl.obolibrary.org/obo/HP_0001122	obsolete Aplasia/Hypoplasia of the choroid				
http://purl.obolibrary.org/obo/HP_0001145	obsolete Chorioretinopathy				
http://purl.obolibrary.org/obo/HP_0001146	obsolete Pigmentary retinal degeneration				
http://purl.obolibrary.org/obo/HP_0001150	obsolete Choroidal sclerosis				
http://purl.obolibrary.org/obo/HP_0001163	obsolete Abnormality of the metacarpal bones				
http://purl.obolibrary.org/obo/HP_0001180	obsolete Hand oligodactyly				
http://purl.obolibrary.org/obo/HP_0001226	obsolete Acral ulceration and osteomyelitis leading to autoamputation of digits				
http://purl.obolibrary.org/obo/HP_0001322	obsolete Brain very small				
http://purl.obolibrary.org/obo/HP_0001379	obsolete Degenerative joint disease				
http://purl.obolibrary.org/obo/HP_0001380	obsolete Ligamentous laxity				
http://purl.obolibrary.org/obo/HP_0001388	obsolete Joint laxity				
http://purl.obolibrary.org/obo/HP_0001400	obsolete Hepatic abscesses due to immunodeficiency				
http://purl.obolibrary.org/obo/HP_0001425	obsolete Heterogeneous				
http://purl.obolibrary.org/obo/HP_0001428	obsolete Somatic mutation				
http://purl.obolibrary.org/obo/HP_0001444	obsolete Autosomal dominant somatic cell mutation				
http://purl.obolibrary.org/obo/HP_0001452	obsolete Autosomal dominant contiguous gene syndrome				
http://purl.obolibrary.org/obo/HP_0001472	obsolete Familial predisposition				
http://purl.obolibrary.org/obo/HP_0001487	obsolete Hypopigmented fundi				
http://purl.obolibrary.org/obo/HP_0001575	obsolete Mood changes				
http://purl.obolibrary.org/obo/HP_0001587	obsolete Primary ovarian failure				
http://purl.obolibrary.org/obo/HP_0001606	obsolete Vocal cord paralysis (caused by tumor impingement)				
http://purl.obolibrary.org/obo/HP_0001613	obsolete Hoarse voice (caused by tumor impingement)				
http://purl.obolibrary.org/obo/HP_0001673	obsolete Tachycardia (with pheochromocytoma)				
http://purl.obolibrary.org/obo/HP_0001675	obsolete Rhythm disturbances associated with pheochromocytoma				
http://purl.obolibrary.org/obo/HP_0001676	obsolete Palpitations (with pheochromocytoma)				
http://purl.obolibrary.org/obo/HP_0001724	obsolete Aortic dilatation				
http://purl.obolibrary.org/obo/HP_0001726	obsolete Increased prevalence of valvular disease				
http://purl.obolibrary.org/obo/HP_0001862	obsolete Acral ulceration and osteomyelitis leading to autoamputation of the digits (feet)				
http://purl.obolibrary.org/obo/HP_0002109	obsolete Abnormality of the bronchi				
http://purl.obolibrary.org/obo/HP_0002111	obsolete Restrictive deficit on pulmonary function testing				
http://purl.obolibrary.org/obo/HP_0002189	obsolete Excessive daytime sleepiness				
http://purl.obolibrary.org/obo/HP_0002229	obsolete Alopecia areata				
http://purl.obolibrary.org/obo/HP_0002271	obsolete Autonomic dysregulation				
http://purl.obolibrary.org/obo/HP_0002275	obsolete Poor motor coordination				
http://purl.obolibrary.org/obo/HP_0002281	obsolete Gray matter heterotopias				
http://purl.obolibrary.org/obo/HP_0002355	obsolete Difficulty walking				
http://purl.obolibrary.org/obo/HP_0002357	obsolete Dysphasia				
http://purl.obolibrary.org/obo/HP_0002370	obsolete Poor coordination				
http://purl.obolibrary.org/obo/HP_0002377	obsolete Paraganglioma-related cranial nerve palsy				
http://purl.obolibrary.org/obo/HP_0002438	obsolete Cerebellar malformation				
http://purl.obolibrary.org/obo/HP_0002459	obsolete Dysautonomia				
http://purl.obolibrary.org/obo/HP_0002564	obsolete Malformation of the heart and great vessels				
http://purl.obolibrary.org/obo/HP_0002622	obsolete Dissecting aortic dilatation				
http://purl.obolibrary.org/obo/HP_0002631	obsolete Dilatation of ascending aorta				
http://purl.obolibrary.org/obo/HP_0002648	obsolete Abnormality of calvarial morphology				
http://purl.obolibrary.org/obo/HP_0002695	obsolete Symmetrical, oval parietal bone defects				
http://purl.obolibrary.org/obo/HP_0002744	obsolete Bilateral cleft lip and palate				
http://purl.obolibrary.org/obo/HP_0002755	obsolete Osteomyelitis due to immunodeficiency				
http://purl.obolibrary.org/obo/HP_0002773	obsolete Small vertebral bodies				
http://purl.obolibrary.org/obo/HP_0002845	obsolete Increased proportion of peripheral CD3+ T cells				
http://purl.obolibrary.org/obo/HP_0002880	obsolete Respiratory difficulties				
http://purl.obolibrary.org/obo/HP_0002924	obsolete Decreased circulating aldosterone level				
http://purl.obolibrary.org/obo/HP_0002961	obsolete Dysgammaglobulinemia				
http://purl.obolibrary.org/obo/HP_0002997	obsolete Abnormality of the ulna				
http://purl.obolibrary.org/obo/HP_0003063	obsolete Abnormality of the humerus				
http://purl.obolibrary.org/obo/HP_0003116	obsolete Abnormal echocardiogram				
http://purl.obolibrary.org/obo/HP_0003152	obsolete Increased serum 1,25-dihydroxyvitamin D3				
http://purl.obolibrary.org/obo/HP_0003295	obsolete Impaired FSH and LH secretion				
http://purl.obolibrary.org/obo/HP_0003335	obsolete Low gonadotropins (secondary hypogonadism)				
http://purl.obolibrary.org/obo/HP_0003347	obsolete Impaired lymphocyte transformation with phytohemagglutinin				
http://purl.obolibrary.org/obo/HP_0003421	obsolete Platyspondyly (childhood)				
http://purl.obolibrary.org/obo/HP_0003464	obsolete Abnormal cholesterol homeostasis				
http://purl.obolibrary.org/obo/HP_0003490	obsolete Defective dehydrogenation of isovaleryl CoA and butyryl CoA				
http://purl.obolibrary.org/obo/HP_0003553	obsolete Cellulitis due to immunodeficiency				
http://purl.obolibrary.org/obo/HP_0003683	obsolete Large beaked nose				
http://purl.obolibrary.org/obo/HP_0003741	obsolete Congenital muscular dystrophy				
http://purl.obolibrary.org/obo/HP_0003783	obsolete Externally rotated/abducted legs				
http://purl.obolibrary.org/obo/HP_0004355	obsolete Abnormality of proteoglycan metabolism				
http://purl.obolibrary.org/obo/HP_0004366	obsolete Abnormality of glycolysis				
http://purl.obolibrary.org/obo/HP_0004367	obsolete Abnormality of glycoprotein metabolism				
http://purl.obolibrary.org/obo/HP_0005111	obsolete Dilatation of the ascending aorta				
http://purl.obolibrary.org/obo/HP_0006919	obsolete Abnormal aggressive, impulsive or violent behavior				
http://purl.obolibrary.org/obo/HP_0008051	obsolete Abnormality of the retinal pigment epithelium				
http://purl.obolibrary.org/obo/HP_0009773	obsolete Symphalangism affecting the phalanges of the hand				
http://purl.obolibrary.org/obo/HP_0010905	obsolete Abnormality of histidine metabolism				
http://purl.obolibrary.org/obo/HP_0010928	obsolete Increased urinary orotic acid concentration				
http://purl.obolibrary.org/obo/HP_0010985	obsolete Gonosomal inheritance				
http://purl.obolibrary.org/obo/HP_0011016	obsolete Abnormality of urine glucose concentration				
http://purl.obolibrary.org/obo/HP_0012140	obsolete Abnormality of cells of the lymphoid lineage				
http://purl.obolibrary.org/obo/HP_0012369	obsolete Abnormal malar bone morphology				
http://purl.obolibrary.org/obo/HP_0012374	obsolete Abnormal globe morphology				
http://purl.obolibrary.org/obo/HP_0100492	obsolete Joint contractures involving the joints of the feet				
http://purl.obolibrary.org/obo/HP_0030960	obsolete Abnormal pupillary morphology				
http://purl.obolibrary.org/obo/HP_0030963	obsolete Abnormal aortic morphology				
http://purl.obolibrary.org/obo/HP_0030971	obsolete Abnormal vena cava morphology				
http://purl.obolibrary.org/obo/HP_5200235	obsolete Disordered formal thought process				
http://purl.obolibrary.org/obo/HP_5200284	obsolete Bruxism during sleep				
http://purl.obolibrary.org/obo/HP_0100786	obsolete Hypersomnia				
http://purl.obolibrary.org/obo/HP_0033919	obsolete Medial/intimal arcuate venulitis				
http://purl.obolibrary.org/obo/HP_5000041	obsolete Anti-CRMP5 antibody positivity				
http://purl.obolibrary.org/obo/HP_5000045	obsolete Anti-MuSK antibody positivity				
http://purl.obolibrary.org/obo/HP_0034027	obsolete Abnormal urinary non-proteinogenic amino acid level				
http://purl.obolibrary.org/obo/HP_0034028	obsolete Saccharopinuria				
http://purl.obolibrary.org/obo/HP_0034041	obsolete Ventricular ectopy				
http://purl.obolibrary.org/obo/CHEBI_35907	glutarate(1-)	http://purl.obolibrary.org/obo/CHEBI_24329	glutarate		A dicarboxylic acid monoanion that is the conjugate base of glutaric acid.
http://purl.obolibrary.org/obo/CHEBI_36110	pipecolate	http://purl.obolibrary.org/obo/CHEBI_36109	piperidinecarboxylate		A piperidinecarboxylate that is the  conjugate base of pipecolic acid.
http://purl.obolibrary.org/obo/CHEBI_37163	glucan	http://purl.obolibrary.org/obo/CHEBI_37164	homopolysaccharide		A polysaccharide composed of glucose residues.
http://purl.obolibrary.org/obo/CHEBI_37397	chondroitin sulfate	http://purl.obolibrary.org/obo/CHEBI_35722	sulfated glycosaminoglycan		Any of a class of 10—60 kDa glycosaminoglycan sulfates, widely distributed in cartilage and other mammalian connective tissues.
http://purl.obolibrary.org/obo/CHEBI_37578	halide	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements.
http://purl.obolibrary.org/obo/CHEBI_38147	cardiotonic drug	http://purl.obolibrary.org/obo/CHEBI_35554	cardiovascular drug		A drug that has a strengthening effect on the heart or that can increase cardiac output.
http://purl.obolibrary.org/obo/CHEBI_38807	calcium channel agonist	http://purl.obolibrary.org/obo/CHEBI_38808	calcium channel modulator		Agents that increase calcium influx into calcium channels of excitable tissues.
http://purl.obolibrary.org/obo/CHEBI_38808	calcium channel modulator	http://purl.obolibrary.org/obo/CHEBI_38632	membrane transport modulator		A membrane transport modulator that is able to regulate intracellular calcium levels.
http://purl.obolibrary.org/obo/CHEBI_39127	magnesium cation	http://purl.obolibrary.org/obo/CHEBI_33513	alkaline earth cation		Any magnesium ion that is positively charged.
http://purl.obolibrary.org/obo/CHEBI_4194	D-hexose	http://purl.obolibrary.org/obo/CHEBI_18133	hexose		A hexose that has <small>D</small>-configuration at position 5.
http://purl.obolibrary.org/obo/CHEBI_43474	hydrogenphosphate	http://purl.obolibrary.org/obo/CHEBI_35780	phosphate ion		A phosphate ion that is the conjugate base of dihydrogenphosphate.
http://purl.obolibrary.org/obo/CHEBI_4439	dermatan	http://purl.obolibrary.org/obo/CHEBI_37395	mucopolysaccharide		A mucopolysaccharide consisting of repeating β-(1→4)-linked <small>L</small>-iduronyl-(α1→3)-<em>N</em>-acetyl-<small>D</small>-galactosamine units.
http://purl.obolibrary.org/obo/CHEBI_45630	4-oxopentanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		An oxopentanoic acid with the oxo group in the 4-position.
http://purl.obolibrary.org/obo/CHEBI_46998	ribofuranose	http://purl.obolibrary.org/obo/CHEBI_33942	ribose		A cyclic ribose having a 5-membered tetrahydrofuran ring; the predominant (C3'-endo) form of the two cyclic structures (the other is the "C2'-endo" form, having a 6-membered ring) adopted by ribose in aqueous solution.
http://purl.obolibrary.org/obo/CHEBI_47013	D-ribofuranose	http://purl.obolibrary.org/obo/CHEBI_16988	D-ribose		A ribofuranose having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_47867	indicator	http://purl.obolibrary.org/obo/CHEBI_33232	application		Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc.
http://purl.obolibrary.org/obo/CHEBI_48430	4-methyl-2-oxopentanoic acid	http://purl.obolibrary.org/obo/CHEBI_191197	branched-chain keto acid		A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
http://purl.obolibrary.org/obo/CHEBI_48873	cholinergic antagonist	http://purl.obolibrary.org/obo/CHEBI_38323	cholinergic drug		Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
http://purl.obolibrary.org/obo/CHEBI_48999	4-hydroxyphenylacetate	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion that is obtained by removal of a proton from the carboxylic acid group of 4-hydroxyphenylacetic acid.
http://purl.obolibrary.org/obo/CHEBI_49096	3-aminoisobutyrate	http://purl.obolibrary.org/obo/CHEBI_49095	beta-amino-acid anion		A β-amino acid anion that is the conjugate base of 3-aminoisobutyric acid, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_50748	antipsoriatic	http://purl.obolibrary.org/obo/CHEBI_50177	dermatologic drug		A drug used to treat psoriasis.
http://purl.obolibrary.org/obo/CHEBI_50846	immunomodulator	http://purl.obolibrary.org/obo/CHEBI_23888	drug		Biologically active substance whose activity affects or plays a role in the functioning of the immune system.
http://purl.obolibrary.org/obo/CHEBI_52090	methoxide	http://purl.obolibrary.org/obo/CHEBI_25696	organic anion		An organic anion that is the conjugate base of methanol.
http://purl.obolibrary.org/obo/CHEBI_533015	3,3',5-triiodo-L-thyronine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		The amino acid zwitterion formed from 3,3',5-triiodo-<small>L</small>-thyronine by tranfer of a proton from the carboxy group to the amino group. It is the major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58048	L-asparagine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of <small>L</small>-asparagine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58065	homocysteine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion of homocysteine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58080	N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of <em>N</em><small><sup>4</small></sup>-(β-<em>N</em>-acetyl-<small>D</small>-glucosaminyl)-<small>L</small>-asparagine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58126	porphobilinogen(1-)	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		Conjugate base of porphobilinogen arising from deprotonation of the two carboxy groups and protonation of the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58163	homocystine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Dizwitterionic form of homocystine arising from transfer of two protons from the carboxy to the amino groups; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58251	N,N-dimethylglycine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion resulting from transfer of a proton from the carboxy to the amino group of <em>N</em>,<em>N</em>-dimethylglycine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58375	trans-4-hydroxy-L-proline zwitterion	http://purl.obolibrary.org/obo/CHEBI_59869	L-alpha-amino acid zwitterion		An <small>L</small>-α-amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of <i>trans</i>-4-hydroxy-<small>L</small>-proline; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58389	trimethylammonium	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		An ammonium ion that is the conjugate acid of trimethylamine, obtained via protonation of the nitrogen; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58402	5-oxo-L-prolinate	http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion		Conjugate base of 5-oxo-<small>L</small>-proline.
http://purl.obolibrary.org/obo/CHEBI_58419	4-hydroxy-L-proline zwitterion	http://purl.obolibrary.org/obo/CHEBI_63137	4-hydroxyproline zwitterion		The amino acid zwitterion formed from 4-hydroxy-<small>L</small>-proline. It is the major microspecies present at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_58465	dermatan sulfate polyanion	http://purl.obolibrary.org/obo/CHEBI_58958	organosulfate oxoanion		The conjugate base of dermatan sulfate, obtained by deprotonation of carboxy and sulfate groups.
http://purl.obolibrary.org/obo/CHEBI_59905	dopaminium(1+)	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		An ammonium ion that is the conjugate acid of dopamine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_60039	L-proline zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		The zwitterion formed from <small>L</small>-proline by proton transfer from the carboxy group to the ring nitrogen. It is the predominant species at physiological pH.
http://purl.obolibrary.org/obo/CHEBI_60308	3,3',5-triiodo-L-thyroninate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		The anion resulting from the removal of the proton from the carboxylic acid group of 3,3',5-triiodo-<small>L</small>-thyronine.
http://purl.obolibrary.org/obo/CHEBI_606565	N-benzoylglycinate	http://purl.obolibrary.org/obo/CHEBI_132966	hippurates		An α-amino-acid anion that is the conjugate base of <em>N</em>-benzoylglycine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_60924	keratan sulfate	http://purl.obolibrary.org/obo/CHEBI_35722	sulfated glycosaminoglycan		A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide  [3)-β-Gal-(1→4)-β-GlcNAc-(1→] and containing sulfo groups located at random positions.
http://purl.obolibrary.org/obo/CHEBI_62803	fuel additive	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		Any additive that enhances the efficiency of fuel.
http://purl.obolibrary.org/obo/CHEBI_62981	4-hydroxy-L-prolinate	http://purl.obolibrary.org/obo/CHEBI_59814	L-alpha-amino acid anion		The <small>L</small>-α-amino acid anion that is the conjugate base of 4-hydroxy-<small>L</small>-proline, formed by proton loss from the carboxy group. It is the major microspecies present at pH > 10.6.
http://purl.obolibrary.org/obo/CHEBI_63624	telbivudine	http://purl.obolibrary.org/obo/CHEBI_19255	pyrimidine 2'-deoxyribonucleoside		A pyrimidine 2'-deoxyribonucleoside that is the <small>L</small>-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase.
http://purl.obolibrary.org/obo/CHEBI_66922	citrullinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino acid anion that is the conjugate base of citrulline, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_66952	homocysteinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino acid anion that is the conjugate base of homocysteine, obtained by deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_68472	pyrimidine deoxyribonucleoside	http://purl.obolibrary.org/obo/CHEBI_26440	pyrimidine nucleoside		A deoxyribonucleoside containing a pyrimidine base.
http://purl.obolibrary.org/obo/CHEBI_73039	O-octanoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine having octanoyl as the acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_73558	D3 vitamins	http://purl.obolibrary.org/obo/CHEBI_27300	vitamin D		A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D<small><sub>3</sub></small>) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D<small><sub>3</sub></small>), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D<small><sub>3</sub></small>), the active hormone.
http://purl.obolibrary.org/obo/CHEBI_75325	cathartic	http://purl.obolibrary.org/obo/CHEBI_52208	biophysical role		Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic.
http://purl.obolibrary.org/obo/CHEBI_77703	EC 4.3.1.3 (histidine ammonia-lyase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76832	EC 4.3.1.* (ammonia-lyase) inhibitor		An EC 4.3.1.* (ammonia-lyase) inhibitor that interferes with the action of histidine ammonia-lyase (EC 4.3.1.3).
http://purl.obolibrary.org/obo/CHEBI_78113	fatty acid anion 3:0	http://purl.obolibrary.org/obo/CHEBI_58951	short-chain fatty acid anion		Any saturated fatty acid anion containing 3 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78115	fatty acid anion 4:0	http://purl.obolibrary.org/obo/CHEBI_58951	short-chain fatty acid anion		Any saturated fatty acid anion containing 4 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues.
http://purl.obolibrary.org/obo/CHEBI_88167	N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide	http://purl.obolibrary.org/obo/CHEBI_61360	globoside		A glycotetraosylceramide having <em>N</em>-acetyl-β-<small>D</small>-galactosaminyl-(1→3)-α-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucosyl  component attached to the primary hydroxy function of a ceramide with undefined sphingoid base.
http://purl.obolibrary.org/obo/CHEBI_305790	thyroxine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		The amino acid zwitterion formed from thyroxine by transfer of a proton from the carboxy group to the amino group.  Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_30697	beta-D-glucosyl group	http://purl.obolibrary.org/obo/CHEBI_24280	D-glucosyl group		A <small>D</small>-glucosyl group obtained by removing the hydroxy group from the hemiacetal function of β-<small>D</small>-glucose and, by extension, of a lower oligosaccharide having β-<small>D</small>-glucose at the reducing end. The unsubstituted parent of the class of β-<small>D</small>-glucosyl groups.
http://purl.obolibrary.org/obo/CHEBI_31013	cerotate	http://purl.obolibrary.org/obo/CHEBI_76619	omega-methyl fatty acid anion		The conjugate base of cerotic acid.
http://purl.obolibrary.org/obo/CHEBI_35804	citrate(1-)	http://purl.obolibrary.org/obo/CHEBI_36299	tricarboxylic acid monoanion		A tricarboxylic acid monoanion that is the conjugate base of citric acid, obtained by deprotonation of one of the three carboxy groups.
http://purl.obolibrary.org/obo/CHEBI_48539	alpha-adrenergic drug	http://purl.obolibrary.org/obo/CHEBI_37962	adrenergic agent		Any drug that acts on an α-adrenergic receptor.
http://purl.obolibrary.org/obo/CHEBI_50103	excitatory amino acid agonist	http://purl.obolibrary.org/obo/CHEBI_35942	neurotransmitter agent		An agent that binds to and activates excitatory amino acid receptors.
http://purl.obolibrary.org/obo/CHEBI_78121	fatty acid anion 14:0	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion containing 14 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78128	fatty acid anion 24:0	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion containing 24 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78129	fatty acid anion 26:0	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion containing 26 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_90318	EC 6.4.1.1 (pyruvate carboxylase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76824	EC 6.4.1.* (carboxylase) inhibitor		An EC 6.4.1.* (carboxylase) inhibitor that interferes with the action of pyruvate carboxylase (EC 6.4.1.1).
http://purl.obolibrary.org/obo/CHEBI_32443	L-cysteinate(2-)	http://purl.obolibrary.org/obo/CHEBI_32457	cysteinate(2-)		The <small>L</small>-enantiomer of cysteinate(2−).
http://purl.obolibrary.org/obo/CHEBI_32450	D-cysteinate(2-)	http://purl.obolibrary.org/obo/CHEBI_32457	cysteinate(2-)		The <small>D</small>-enantiomer of cysteinate(2−).
http://purl.obolibrary.org/obo/CHEBI_32565	lysinium(2+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation obtained by protonation of both amino groups of lysine.
http://purl.obolibrary.org/obo/CHEBI_33224	chromane	http://purl.obolibrary.org/obo/CHEBI_23230	chromanes		A benzopyran consisting of a pyran ring having a benzene ring <em>ortho</em>-fused across positions 2 and 3.
http://purl.obolibrary.org/obo/CHEBI_33233	fundamental particle	http://purl.obolibrary.org/obo/CHEBI_36342	subatomic particle		A particle not known to have substructure.
http://purl.obolibrary.org/obo/CHEBI_33273	polyatomic anion	http://purl.obolibrary.org/obo/CHEBI_36358	polyatomic ion		An anion consisting of more than one atom.
http://purl.obolibrary.org/obo/CHEBI_33290	food	http://purl.obolibrary.org/obo/CHEBI_52211	physiological role		A physiological role played by any substance of either plant, animal or artificial origin which contains essential body nutrients that can be ingested by an organism to provide energy, promote growth, and maintain the processes of life.
http://purl.obolibrary.org/obo/CHEBI_33579	main group molecular entity	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound	http://purl.obolibrary.org/obo/CHEBI_25367	molecule		Any molecule that consists of a series of atoms joined together to form a ring.
http://purl.obolibrary.org/obo/CHEBI_33597	homocyclic compound	http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound		A cyclic compound having as ring members atoms of the same element only.
http://purl.obolibrary.org/obo/CHEBI_33636	bicyclic compound	http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound		A molecule that features two fused rings.
http://purl.obolibrary.org/obo/CHEBI_33662	annulene	http://purl.obolibrary.org/obo/CHEBI_33664	monocyclic hydrocarbon		A mancude monocyclic hydrocarbon without side chains of the general formula C<small><sub><em>n</em></sub></small>H<small><sub><em>n</em></sub></small> (<em>n</em> is an even number) or C<small><sub><em>n</em></sub></small>H<small><sub><em>n</em>+1</sub></small> (<em>n</em> is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [<em>n</em>]annulene, where <em>n</em> is the number of carbon atoms.
http://purl.obolibrary.org/obo/CHEBI_33671	heteropolycyclic compound	http://purl.obolibrary.org/obo/CHEBI_33635	polycyclic compound		A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.
http://purl.obolibrary.org/obo/CHEBI_33674	s-block molecular entity	http://purl.obolibrary.org/obo/CHEBI_33579	main group molecular entity		An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
http://purl.obolibrary.org/obo/CHEBI_33676	d-block molecular entity	http://purl.obolibrary.org/obo/CHEBI_33497	transition element molecular entity		A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element.
http://purl.obolibrary.org/obo/CHEBI_33692	hydrides	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		Hydrides are chemical compounds of hydrogen with other chemical elements.
http://purl.obolibrary.org/obo/CHEBI_33710	alpha-amino-acid residue	http://purl.obolibrary.org/obo/CHEBI_33708	amino-acid residue		An amino-acid residue derived from an α-amino acid.
http://purl.obolibrary.org/obo/CHEBI_33847	monocyclic arene	http://purl.obolibrary.org/obo/CHEBI_33658	arene		A monocyclic aromatic hydrocarbon.
http://purl.obolibrary.org/obo/CHEBI_36003	decenoic acid	http://purl.obolibrary.org/obo/CHEBI_59202	straight-chain fatty acid		Any C<small><sub>10</sub></small> monounsaturated fatty acid having a double bond in the carbon backbone.
http://purl.obolibrary.org/obo/CHEBI_36339	baryon	http://purl.obolibrary.org/obo/CHEBI_36344	hadron		Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek βαρυσ (heavy).
http://purl.obolibrary.org/obo/CHEBI_36347	nuclear particle	http://purl.obolibrary.org/obo/CHEBI_36342	subatomic particle		A nucleus or any of its constituents in any of their energy states.
http://purl.obolibrary.org/obo/CHEBI_45212	diphosphate(2-)	http://purl.obolibrary.org/obo/CHEBI_79388	divalent inorganic anion		A divalent inorganic anion obtained by removal of both protons from diphosphoric acid.
http://purl.obolibrary.org/obo/CHEBI_52211	physiological role	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A biological role relating to the normal mechanisms and their interactions within a living system.
http://purl.obolibrary.org/obo/CHEBI_64709	organic acid	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		Any organic molecular entity that is acidic and contains carbon in covalent linkage.
http://purl.obolibrary.org/obo/CHEBI_76042	aromatic amino-acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid.
http://purl.obolibrary.org/obo/CHEBI_78631	chroman-6-ol	http://purl.obolibrary.org/obo/CHEBI_33853	phenols		A chromanol that is chromane in which the hydrogen at position 6 is replaced by a hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_91007	aromatic carboxylate	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_46819	urate salt	http://purl.obolibrary.org/obo/CHEBI_24868	organic salt		An organic salt of uric acid.
http://purl.obolibrary.org/obo/CHEBI_48359	protophilic solvent	http://purl.obolibrary.org/obo/CHEBI_48354	polar solvent		Solvent that is capable of acting as a hydron (proton) acceptor.
http://purl.obolibrary.org/obo/CHEBI_48377	imidic acid	http://purl.obolibrary.org/obo/CHEBI_33241	oxoacid derivative		Compounds derived from oxoacids R<small><sub><em>k</em></sub></small>E(=O)<small><sub><em>l</em></sub></small>(OH)<small><sub><em>m</em></sub></small> (<em>l</em> ≠ 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH).
http://purl.obolibrary.org/obo/CHEBI_48379	isourea	http://purl.obolibrary.org/obo/CHEBI_48378	carboximidic acid		A carboximidic acid that is the imidic acid tautomer of urea, H<small><sub>2</sub></small>NC(=NH)OH, and its hydrocarbyl derivatives.
http://purl.obolibrary.org/obo/CHEBI_50404	lipoprotein cholesterol	http://purl.obolibrary.org/obo/CHEBI_50401	cholestanoid		Cholesterol esters and free cholesterol which are contained in or bound to lipoproteins.
http://purl.obolibrary.org/obo/CHEBI_58717	S-substituted L-cysteine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		The zwitterionic form of an <em>S</em>-substituted <small>L</small>-cysteine.
http://purl.obolibrary.org/obo/CHEBI_59999	chemical substance	http://purl.obolibrary.org/obo/CHEBI_24431	chemical entity		A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
http://purl.obolibrary.org/obo/CHEBI_51340	pristanic acid	http://purl.obolibrary.org/obo/CHEBI_62499	methyl-branched fatty acid		A branched, long-chain saturated fatty acid composed of pentadecanoic acid having methyl substituents at the 2-, 6-, 10- and 14-positions.
http://purl.obolibrary.org/obo/CHEBI_51721	alpha,beta-unsaturated ketone	http://purl.obolibrary.org/obo/CHEBI_17087	ketone		A ketone of general formula R<small><sup>1</small></sup>R<small><sup>2</small></sup>C=CR<small><sup>3</small></sup>‒C(=O)R<small><sup>4</small></sup> (R<small><sup>4</small></sup> ≠ H) or R<small><sup>1</small></sup>C≡C‒C(=O)R<small><sup>2</small></sup> (R<small><sup>2</small></sup> ≠ H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the α,β position.
http://purl.obolibrary.org/obo/CHEBI_52254	apatite	http://purl.obolibrary.org/obo/CHEBI_46723	phosphate mineral		A phosphate mineral with the general formula Ca<small><sub>5</sub></small>(PO<small><sub>4</sub></small>)<small><sub>3</sub></small>X where X = OH, F or Cl.
http://purl.obolibrary.org/obo/CHEBI_52255	hydroxylapatite	http://purl.obolibrary.org/obo/CHEBI_52254	apatite		A phosphate mineral with the formula Ca<small><sub>5</sub></small>(PO<small><sub>4</sub></small>)<small><sub>3</sub></small>(OH).
http://purl.obolibrary.org/obo/CHEBI_52845	cyclic organic group	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		An organic group that consists of a closed ring. It may be a substituent or a skeleton.
http://purl.obolibrary.org/obo/CHEBI_53309	polyanionic macromolecule	http://purl.obolibrary.org/obo/CHEBI_53368	ionic macromolecule		A polymer carrying multiple negative charges.
http://purl.obolibrary.org/obo/CHEBI_53368	ionic macromolecule	http://purl.obolibrary.org/obo/CHEBI_33839	macromolecule		A macromolecule containing ionic groups.
http://purl.obolibrary.org/obo/CHEBI_76761	EC 3.2.* (glycosylase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76759	EC 3.* (hydrolase) inhibitor		A hydrolase inhibitor that interferes with the action of any glycosylase (EC 3.2.*.*).
http://purl.obolibrary.org/obo/CHEBI_86052	O-octenoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		An <em>O</em>-acylcarnitine in which the acyl group specified is octenoyl.
http://purl.obolibrary.org/obo/GO_0004556	alpha-amylase activity	http://purl.obolibrary.org/obo/GO_0016160	amylase activity		Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.
http://purl.obolibrary.org/obo/GO_0004565	beta-galactosidase activity	http://purl.obolibrary.org/obo/GO_0015925	galactosidase activity		Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.
http://purl.obolibrary.org/obo/GO_0004658	propionyl-CoA carboxylase activity	http://purl.obolibrary.org/obo/GO_0016421	CoA carboxylase activity		Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.
http://purl.obolibrary.org/obo/GO_0004736	pyruvate carboxylase activity	http://purl.obolibrary.org/obo/GO_0016885	ligase activity, forming carbon-carbon bonds		Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H+ + oxaloacetate + phosphate.
http://purl.obolibrary.org/obo/GO_0005215	transporter activity	http://purl.obolibrary.org/obo/GO_0003674	molecular_function		Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.
http://purl.obolibrary.org/obo/GO_0005576	extracellular region	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
http://purl.obolibrary.org/obo/GO_0005577	fibrinogen complex	http://purl.obolibrary.org/obo/GO_0140392	extracellular protein-containing complex		A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.
http://purl.obolibrary.org/obo/GO_0005581	collagen trimer	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
http://purl.obolibrary.org/obo/GO_0005583	fibrillar collagen trimer	http://purl.obolibrary.org/obo/GO_0140392	extracellular protein-containing complex		Any triple helical collagen trimer that forms fibrils.
http://purl.obolibrary.org/obo/GO_0005584	collagen type I trimer	http://purl.obolibrary.org/obo/GO_0005583	fibrillar collagen trimer		A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.
http://purl.obolibrary.org/obo/GO_0005585	collagen type II trimer	http://purl.obolibrary.org/obo/GO_0005583	fibrillar collagen trimer		A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.
http://purl.obolibrary.org/obo/GO_0005587	collagen type IV trimer	http://purl.obolibrary.org/obo/GO_0098642	network-forming collagen trimer		A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.
http://purl.obolibrary.org/obo/GO_0005604	basement membrane	http://purl.obolibrary.org/obo/GO_0031012	extracellular matrix		A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
http://purl.obolibrary.org/obo/GO_0005614	interstitial matrix	http://purl.obolibrary.org/obo/GO_0031012	extracellular matrix		A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.
http://purl.obolibrary.org/obo/GO_0005635	nuclear envelope	http://purl.obolibrary.org/obo/GO_0031967	organelle envelope		The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport.
http://purl.obolibrary.org/obo/GO_0005730	nucleolus	http://purl.obolibrary.org/obo/GO_0043232	intracellular membraneless organelle		A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
http://purl.obolibrary.org/obo/GO_0005740	mitochondrial envelope	http://purl.obolibrary.org/obo/GO_0031967	organelle envelope		The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.
http://purl.obolibrary.org/obo/GO_0005759	mitochondrial matrix	http://purl.obolibrary.org/obo/GO_0070013	intracellular organelle lumen		The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
http://purl.obolibrary.org/obo/GO_0005761	mitochondrial ribosome	http://purl.obolibrary.org/obo/GO_0000313	organellar ribosome		A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.
http://purl.obolibrary.org/obo/GO_0005766	primary lysosome	http://purl.obolibrary.org/obo/GO_0005764	lysosome		A lysosome before it has fused with a vesicle or vacuole.
http://purl.obolibrary.org/obo/GO_0005856	cytoskeleton	http://purl.obolibrary.org/obo/GO_0043232	intracellular membraneless organelle		A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
http://purl.obolibrary.org/obo/GO_0005882	intermediate filament	http://purl.obolibrary.org/obo/GO_0099513	polymeric cytoskeletal fiber		A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
http://purl.obolibrary.org/obo/GO_0005884	actin filament	http://purl.obolibrary.org/obo/GO_0099513	polymeric cytoskeletal fiber		A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
http://purl.obolibrary.org/obo/GO_0005902	microvillus	http://purl.obolibrary.org/obo/GO_0098858	actin-based cell projection		Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
http://purl.obolibrary.org/obo/GO_0005911	cell-cell junction	http://purl.obolibrary.org/obo/GO_0070161	anchoring junction		A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
http://purl.obolibrary.org/obo/GO_0005929	cilium	http://purl.obolibrary.org/obo/GO_0043227	membrane-bounded organelle		A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
http://purl.obolibrary.org/obo/GO_0005938	cell cortex	http://purl.obolibrary.org/obo/GO_0005737	cytoplasm		The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
http://purl.obolibrary.org/obo/GO_0005975	carbohydrate metabolic process	http://purl.obolibrary.org/obo/GO_0044238	primary metabolic process		The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
http://purl.obolibrary.org/obo/GO_0005978	glycogen biosynthetic process	http://purl.obolibrary.org/obo/GO_0005977	glycogen metabolic process		The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
http://purl.obolibrary.org/obo/GO_0005979	regulation of glycogen biosynthetic process	http://purl.obolibrary.org/obo/GO_0070873	regulation of glycogen metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
http://purl.obolibrary.org/obo/GO_0005980	glycogen catabolic process	http://purl.obolibrary.org/obo/GO_0005977	glycogen metabolic process		The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
http://purl.obolibrary.org/obo/GO_0005981	regulation of glycogen catabolic process	http://purl.obolibrary.org/obo/GO_0070873	regulation of glycogen metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.
http://purl.obolibrary.org/obo/GO_0005982	starch metabolic process	http://purl.obolibrary.org/obo/GO_0044042	glucan metabolic process		The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.
http://purl.obolibrary.org/obo/GO_0005983	starch catabolic process	http://purl.obolibrary.org/obo/GO_0009251	glucan catabolic process		The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants.
http://purl.obolibrary.org/obo/GO_0005996	monosaccharide metabolic process	http://purl.obolibrary.org/obo/GO_0044281	small molecule metabolic process		The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
http://purl.obolibrary.org/obo/GO_0006000	fructose metabolic process	http://purl.obolibrary.org/obo/GO_0019318	hexose metabolic process		The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.
http://purl.obolibrary.org/obo/GO_0006006	glucose metabolic process	http://purl.obolibrary.org/obo/GO_0019318	hexose metabolic process		The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
http://purl.obolibrary.org/obo/GO_0006012	galactose metabolic process	http://purl.obolibrary.org/obo/GO_0019318	hexose metabolic process		The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.
http://purl.obolibrary.org/obo/GO_0006022	aminoglycan metabolic process	http://purl.obolibrary.org/obo/GO_1901135	carbohydrate derivative metabolic process		The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.
http://purl.obolibrary.org/obo/GO_0006029	proteoglycan metabolic process	http://purl.obolibrary.org/obo/GO_0009100	glycoprotein metabolic process		The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.
http://purl.obolibrary.org/obo/GO_0006081	aldehyde metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
http://purl.obolibrary.org/obo/GO_0006091	generation of precursor metabolites and energy	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
http://purl.obolibrary.org/obo/GO_0006094	gluconeogenesis	http://purl.obolibrary.org/obo/GO_0019319	hexose biosynthetic process		The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
http://purl.obolibrary.org/obo/GO_0006109	regulation of carbohydrate metabolic process	http://purl.obolibrary.org/obo/GO_0080090	regulation of primary metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.
http://purl.obolibrary.org/obo/GO_0006111	regulation of gluconeogenesis	http://purl.obolibrary.org/obo/GO_0043255	regulation of carbohydrate biosynthetic process		Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
http://purl.obolibrary.org/obo/GO_0006112	energy reserve metabolic process	http://purl.obolibrary.org/obo/GO_0015980	energy derivation by oxidation of organic compounds		The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
http://purl.obolibrary.org/obo/GO_0006139	nucleobase-containing compound metabolic process	http://purl.obolibrary.org/obo/GO_0044238	primary metabolic process		Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
http://purl.obolibrary.org/obo/GO_0006282	regulation of DNA repair	http://purl.obolibrary.org/obo/GO_0080135	regulation of cellular response to stress		Any process that modulates the frequency, rate or extent of DNA repair.
http://purl.obolibrary.org/obo/GO_0006399	tRNA metabolic process	http://purl.obolibrary.org/obo/GO_0016070	RNA metabolic process		The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.
http://purl.obolibrary.org/obo/GO_0006417	regulation of translation	http://purl.obolibrary.org/obo/GO_0051246	regulation of protein metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
http://purl.obolibrary.org/obo/GO_0006446	regulation of translational initiation	http://purl.obolibrary.org/obo/GO_0006417	regulation of translation		Any process that modulates the frequency, rate or extent of translational initiation.
http://purl.obolibrary.org/obo/GO_0006448	regulation of translational elongation	http://purl.obolibrary.org/obo/GO_0006417	regulation of translation		Any process that modulates the frequency, rate, extent or accuracy of translational elongation.
http://purl.obolibrary.org/obo/GO_0006449	regulation of translational termination	http://purl.obolibrary.org/obo/GO_0043244	regulation of protein-containing complex disassembly		Any process that modulates the frequency, rate or extent of translational termination.
http://purl.obolibrary.org/obo/GO_0006487	protein N-linked glycosylation	http://purl.obolibrary.org/obo/GO_0009101	glycoprotein biosynthetic process		A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of an asparagine residue.
http://purl.obolibrary.org/obo/GO_0006493	protein O-linked glycosylation	http://purl.obolibrary.org/obo/GO_0009101	glycoprotein biosynthetic process		A glycoprotein biosynthetic process starting with the covalent linkage of carbohydrate or carbohydrate derivative unit via a glycosidic bond to the oxygen atom of a serine, threonine, hydroxylysine, hydroxyproline or tyrosine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan.
http://purl.obolibrary.org/obo/GO_0006555	L-methionine metabolic process	http://purl.obolibrary.org/obo/GO_0170033	L-amino acid metabolic process		The chemical reactions and pathways involving L-methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
http://purl.obolibrary.org/obo/GO_0006582	melanin metabolic process	http://purl.obolibrary.org/obo/GO_0042440	pigment metabolic process		The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.
http://purl.obolibrary.org/obo/GO_0006590	thyroid hormone generation	http://purl.obolibrary.org/obo/GO_0042403	thyroid hormone metabolic process		The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
http://purl.obolibrary.org/obo/GO_0006624	vacuolar protein processing	http://purl.obolibrary.org/obo/GO_0016485	protein processing		Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.
http://purl.obolibrary.org/obo/GO_0006629	lipid metabolic process	http://purl.obolibrary.org/obo/GO_0044238	primary metabolic process		The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
http://purl.obolibrary.org/obo/GO_0006664	glycolipid metabolic process	http://purl.obolibrary.org/obo/GO_1903509	liposaccharide metabolic process		The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.
http://purl.obolibrary.org/obo/GO_0006665	sphingolipid metabolic process	http://purl.obolibrary.org/obo/GO_0006629	lipid metabolic process		The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
http://purl.obolibrary.org/obo/GO_0006694	steroid biosynthetic process	http://purl.obolibrary.org/obo/GO_0008610	lipid biosynthetic process		The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
http://purl.obolibrary.org/obo/GO_0006699	bile acid biosynthetic process	http://purl.obolibrary.org/obo/GO_0072330	monocarboxylic acid biosynthetic process		The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
http://purl.obolibrary.org/obo/GO_0006704	glucocorticoid biosynthetic process	http://purl.obolibrary.org/obo/GO_0008211	glucocorticoid metabolic process		The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
http://purl.obolibrary.org/obo/GO_0006705	mineralocorticoid biosynthetic process	http://purl.obolibrary.org/obo/GO_0042446	hormone biosynthetic process		The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
http://purl.obolibrary.org/obo/GO_0006720	isoprenoid metabolic process	http://purl.obolibrary.org/obo/GO_0006629	lipid metabolic process		The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
http://purl.obolibrary.org/obo/GO_0006721	terpenoid metabolic process	http://purl.obolibrary.org/obo/GO_0006720	isoprenoid metabolic process		The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups.
http://purl.obolibrary.org/obo/GO_0006766	vitamin metabolic process	http://purl.obolibrary.org/obo/GO_0044281	small molecule metabolic process		The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.
http://purl.obolibrary.org/obo/GO_0006776	vitamin A metabolic process	http://purl.obolibrary.org/obo/GO_0001523	retinoid metabolic process		The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.
http://purl.obolibrary.org/obo/GO_0006796	phosphate-containing compound metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
http://purl.obolibrary.org/obo/GO_0006801	superoxide metabolic process	http://purl.obolibrary.org/obo/GO_0072593	reactive oxygen species metabolic process		The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
http://purl.obolibrary.org/obo/GO_0006810	transport	http://purl.obolibrary.org/obo/GO_0051234	establishment of localization		The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.
http://purl.obolibrary.org/obo/GO_0006811	monoatomic ion transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
http://purl.obolibrary.org/obo/GO_0006835	dicarboxylic acid transport	http://purl.obolibrary.org/obo/GO_0046942	carboxylic acid transport		The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0006858	extracellular transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The transport of substances that occurs outside cells.
http://purl.obolibrary.org/obo/GO_0006860	extracellular amino acid transport	http://purl.obolibrary.org/obo/GO_0006865	amino acid transport		The directed extracellular movement of amino acids.
http://purl.obolibrary.org/obo/GO_0006873	intracellular monoatomic ion homeostasis	http://purl.obolibrary.org/obo/GO_0055082	intracellular chemical homeostasis		A homeostatic process involved in the maintenance of a steady state level of monoatomic ions within a cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
http://purl.obolibrary.org/obo/GO_0006874	intracellular calcium ion homeostasis	http://purl.obolibrary.org/obo/GO_0055074	calcium ion homeostasis		A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.
http://purl.obolibrary.org/obo/GO_0006887	exocytosis	http://purl.obolibrary.org/obo/GO_0032940	secretion by cell		A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
http://purl.obolibrary.org/obo/GO_0006892	post-Golgi vesicle-mediated transport	http://purl.obolibrary.org/obo/GO_0048193	Golgi vesicle transport		The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
http://purl.obolibrary.org/obo/GO_0006893	Golgi to plasma membrane transport	http://purl.obolibrary.org/obo/GO_0098876	vesicle-mediated transport to the plasma membrane		The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. Golgi to plasma membrane transport precedes exocytosis.
http://purl.obolibrary.org/obo/GO_0006897	endocytosis	http://purl.obolibrary.org/obo/GO_0098657	import into cell		A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.
http://purl.obolibrary.org/obo/GO_0006900	vesicle budding from membrane	http://purl.obolibrary.org/obo/GO_0016050	vesicle organization		The evagination of a membrane, resulting in formation of a vesicle.
http://purl.obolibrary.org/obo/GO_0006906	vesicle fusion	http://purl.obolibrary.org/obo/GO_0090174	organelle membrane fusion		Fusion of the membrane of a transport vesicle with its target membrane.
http://purl.obolibrary.org/obo/GO_0006921	cellular component disassembly involved in execution phase of apoptosis	http://purl.obolibrary.org/obo/GO_0022411	cellular component disassembly		The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.
http://purl.obolibrary.org/obo/GO_0006935	chemotaxis	http://purl.obolibrary.org/obo/GO_0042330	taxis		The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
http://purl.obolibrary.org/obo/GO_0006936	muscle contraction	http://purl.obolibrary.org/obo/GO_0003012	muscle system process		A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
http://purl.obolibrary.org/obo/GO_0006937	regulation of muscle contraction	http://purl.obolibrary.org/obo/GO_0090257	regulation of muscle system process		Any process that modulates the frequency, rate or extent of muscle contraction.
http://purl.obolibrary.org/obo/GO_0006939	smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006936	muscle contraction		A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
http://purl.obolibrary.org/obo/GO_0006942	regulation of striated muscle contraction	http://purl.obolibrary.org/obo/GO_0006937	regulation of muscle contraction		Any process that modulates the frequency, rate or extent of striated muscle contraction.
http://purl.obolibrary.org/obo/GO_0006996	organelle organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
http://purl.obolibrary.org/obo/GO_0007006	mitochondrial membrane organization	http://purl.obolibrary.org/obo/GO_0007005	mitochondrion organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
http://purl.obolibrary.org/obo/GO_0007036	vacuolar calcium ion homeostasis	http://purl.obolibrary.org/obo/GO_0006874	intracellular calcium ion homeostasis		Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings.
http://purl.obolibrary.org/obo/GO_0007059	chromosome segregation	http://purl.obolibrary.org/obo/GO_0022402	cell cycle process		The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
http://purl.obolibrary.org/obo/GO_0007076	mitotic chromosome condensation	http://purl.obolibrary.org/obo/GO_1903047	mitotic cell cycle process		The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
http://purl.obolibrary.org/obo/GO_0007088	regulation of mitotic nuclear division	http://purl.obolibrary.org/obo/GO_0051783	regulation of nuclear division		Any process that modulates the frequency, rate or extent of mitosis.
http://purl.obolibrary.org/obo/GO_0007113	endomitotic cell cycle	http://purl.obolibrary.org/obo/GO_0000278	mitotic cell cycle		A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.
http://purl.obolibrary.org/obo/GO_0007135	meiosis II	http://purl.obolibrary.org/obo/GO_0061983	meiosis II cell cycle process		The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II.
http://purl.obolibrary.org/obo/GO_0007140	male meiotic nuclear division	http://purl.obolibrary.org/obo/GO_0140013	meiotic nuclear division		A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
http://purl.obolibrary.org/obo/GO_0007142	male meiosis II	http://purl.obolibrary.org/obo/GO_0007140	male meiotic nuclear division		A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline.
http://purl.obolibrary.org/obo/GO_0007143	female meiotic nuclear division	http://purl.obolibrary.org/obo/GO_0140013	meiotic nuclear division		A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.
http://purl.obolibrary.org/obo/GO_0007147	female meiosis II	http://purl.obolibrary.org/obo/GO_0007143	female meiotic nuclear division		The cell cycle process in which the second meiotic division occurs in the female germline.
http://purl.obolibrary.org/obo/GO_0007159	leukocyte cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0098609	cell-cell adhesion		The attachment of a leukocyte to another cell via adhesion molecules.
http://purl.obolibrary.org/obo/GO_0007162	negative regulation of cell adhesion	http://purl.obolibrary.org/obo/GO_0030155	regulation of cell adhesion		Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
http://purl.obolibrary.org/obo/GO_0007268	chemical synaptic transmission	http://purl.obolibrary.org/obo/GO_0098916	anterograde trans-synaptic signaling		The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
http://purl.obolibrary.org/obo/GO_0007272	ensheathment of neurons	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.
http://purl.obolibrary.org/obo/GO_0007274	neuromuscular synaptic transmission	http://purl.obolibrary.org/obo/GO_0007268	chemical synaptic transmission		The process of synaptic transmission from a neuron to a muscle, across a synapse.
http://purl.obolibrary.org/obo/GO_0007276	gamete generation	http://purl.obolibrary.org/obo/GO_0048609	multicellular organismal reproductive process		The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.
http://purl.obolibrary.org/obo/GO_0007281	germ cell development	http://purl.obolibrary.org/obo/GO_0048468	cell development		The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
http://purl.obolibrary.org/obo/GO_0007283	spermatogenesis	http://purl.obolibrary.org/obo/GO_0003006	developmental process involved in reproduction		The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
http://purl.obolibrary.org/obo/GO_0007288	sperm axoneme assembly	http://purl.obolibrary.org/obo/GO_0003006	developmental process involved in reproduction		The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
http://purl.obolibrary.org/obo/GO_0007289	spermatid nucleus differentiation	http://purl.obolibrary.org/obo/GO_0006997	nucleus organization		The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.
http://purl.obolibrary.org/obo/GO_0007292	female gamete generation	http://purl.obolibrary.org/obo/GO_0007276	gamete generation		Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
http://purl.obolibrary.org/obo/GO_0007320	insemination	http://purl.obolibrary.org/obo/GO_0044703	multi-organism reproductive process		The introduction of semen or sperm into the genital tract of a female.
http://purl.obolibrary.org/obo/GO_0007338	single fertilization	http://purl.obolibrary.org/obo/GO_0009566	fertilization		The union of male and female gametes to form a zygote.
http://purl.obolibrary.org/obo/GO_0007346	regulation of mitotic cell cycle	http://purl.obolibrary.org/obo/GO_0051726	regulation of cell cycle		Any process that modulates the rate or extent of progress through the mitotic cell cycle.
http://purl.obolibrary.org/obo/GO_0007399	nervous system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
http://purl.obolibrary.org/obo/GO_0007417	central nervous system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
http://purl.obolibrary.org/obo/GO_0007422	peripheral nervous system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
http://purl.obolibrary.org/obo/GO_0007498	mesoderm development	http://purl.obolibrary.org/obo/GO_0009888	tissue development		The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
http://purl.obolibrary.org/obo/GO_0007548	sex differentiation	http://purl.obolibrary.org/obo/GO_0003006	developmental process involved in reproduction		The establishment of the sex of an organism by physical differentiation.
http://purl.obolibrary.org/obo/GO_0007565	female pregnancy	http://purl.obolibrary.org/obo/GO_0044703	multi-organism reproductive process		The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
http://purl.obolibrary.org/obo/GO_0007567	parturition	http://purl.obolibrary.org/obo/GO_0044703	multi-organism reproductive process		The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.
http://purl.obolibrary.org/obo/GO_0007586	digestion	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
http://purl.obolibrary.org/obo/GO_0007588	excretion	http://purl.obolibrary.org/obo/GO_0003008	system process		The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
http://purl.obolibrary.org/obo/GO_0007589	body fluid secretion	http://purl.obolibrary.org/obo/GO_0050878	regulation of body fluid levels		The controlled release of a fluid by a cell or tissue in an animal.
http://purl.obolibrary.org/obo/GO_0007595	lactation	http://purl.obolibrary.org/obo/GO_0007589	body fluid secretion		The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
http://purl.obolibrary.org/obo/GO_0007596	blood coagulation	http://purl.obolibrary.org/obo/GO_0050817	coagulation		The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
http://purl.obolibrary.org/obo/GO_0007597	blood coagulation, intrinsic pathway	http://purl.obolibrary.org/obo/GO_0072376	protein activation cascade		A protein activation cascade that initiates blood coagulation, triggered when Factor XII, prekallikrein (PK) and high-molecular-weight kininogen  (HK) assemble on a suitable surface or polymer. This results in the reciprocal activation of factor XII to Factor XIIa by kallikrein, and PK to kallikrein by Factor XIIa. The resulting generation of Factor XIIa activates Factor XI to Factor XIa, which then converts Factor IX to Factor IXa. Factor IXa converts Factor X to Xa. Factor Xa then initiates the common pathway.
http://purl.obolibrary.org/obo/GO_0007598	blood coagulation, extrinsic pathway	http://purl.obolibrary.org/obo/GO_0072376	protein activation cascade		A protein activation cascade that initiates blood coagulation, starting with a signal from tissue factor (TF), a cell-surface, integral-membrane protein, which converts Factor IX to IXa, and Factor IXa converts Factor X to Xa. Factor Xa then initiates the common pathway.
http://purl.obolibrary.org/obo/GO_0007599	hemostasis	http://purl.obolibrary.org/obo/GO_0050878	regulation of body fluid levels		The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
http://purl.obolibrary.org/obo/GO_0007600	sensory perception	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
http://purl.obolibrary.org/obo/GO_0007601	visual perception	http://purl.obolibrary.org/obo/GO_0050953	sensory perception of light stimulus		The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
http://purl.obolibrary.org/obo/GO_0007605	sensory perception of sound	http://purl.obolibrary.org/obo/GO_0050954	sensory perception of mechanical stimulus		The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
http://purl.obolibrary.org/obo/GO_0007606	sensory perception of chemical stimulus	http://purl.obolibrary.org/obo/GO_0007600	sensory perception		The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
http://purl.obolibrary.org/obo/GO_0007608	sensory perception of smell	http://purl.obolibrary.org/obo/GO_0007606	sensory perception of chemical stimulus		The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
http://purl.obolibrary.org/obo/GO_0007611	learning or memory	http://purl.obolibrary.org/obo/GO_0007610	behavior		The acquisition and processing of information and/or the storage and retrieval of this information over time.
http://purl.obolibrary.org/obo/GO_0007613	memory	http://purl.obolibrary.org/obo/GO_0007611	learning or memory		The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
http://purl.obolibrary.org/obo/GO_0007617	mating behavior	http://purl.obolibrary.org/obo/GO_0019098	reproductive behavior		The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.
http://purl.obolibrary.org/obo/GO_0007620	copulation	http://purl.obolibrary.org/obo/GO_0007617	mating behavior		The act of sexual union between male and female, involving the transfer of sperm.
http://purl.obolibrary.org/obo/GO_0007622	rhythmic behavior	http://purl.obolibrary.org/obo/GO_0007610	behavior		The specific behavior of an organism that recur with measured regularity.
http://purl.obolibrary.org/obo/GO_0007626	locomotory behavior	http://purl.obolibrary.org/obo/GO_0007610	behavior		The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
http://purl.obolibrary.org/obo/GO_0008015	blood circulation	http://purl.obolibrary.org/obo/GO_0003013	circulatory system process		The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
http://purl.obolibrary.org/obo/GO_0008104	intracellular protein localization	http://purl.obolibrary.org/obo/GO_0033036	macromolecule localization		Any process in which a protein is transported to, or maintained in, a specific location.
http://purl.obolibrary.org/obo/GO_0008152	metabolic process	http://purl.obolibrary.org/obo/GO_0009987	cellular process		A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well  macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
http://purl.obolibrary.org/obo/GO_0008202	steroid metabolic process	http://purl.obolibrary.org/obo/GO_0006629	lipid metabolic process		The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
http://purl.obolibrary.org/obo/GO_0008211	glucocorticoid metabolic process	http://purl.obolibrary.org/obo/GO_0008202	steroid metabolic process		The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
http://purl.obolibrary.org/obo/GO_0008212	mineralocorticoid metabolic process	http://purl.obolibrary.org/obo/GO_0042445	hormone metabolic process		The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance.
http://purl.obolibrary.org/obo/GO_0008610	lipid biosynthetic process	http://purl.obolibrary.org/obo/GO_0009058	biosynthetic process		The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
http://purl.obolibrary.org/obo/GO_0009100	glycoprotein metabolic process	http://purl.obolibrary.org/obo/GO_1901135	carbohydrate derivative metabolic process		The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
http://purl.obolibrary.org/obo/GO_0009101	glycoprotein biosynthetic process	http://purl.obolibrary.org/obo/GO_0009059	macromolecule biosynthetic process		The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
http://purl.obolibrary.org/obo/GO_0009250	glucan biosynthetic process	http://purl.obolibrary.org/obo/GO_0000271	polysaccharide biosynthetic process		The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.
http://purl.obolibrary.org/obo/GO_0009251	glucan catabolic process	http://purl.obolibrary.org/obo/GO_0000272	polysaccharide catabolic process		The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.
http://purl.obolibrary.org/obo/GO_0009416	response to light stimulus	http://purl.obolibrary.org/obo/GO_0009314	response to radiation		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
http://purl.obolibrary.org/obo/GO_0009566	fertilization	http://purl.obolibrary.org/obo/GO_0022414	reproductive process		The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
http://purl.obolibrary.org/obo/GO_0009583	detection of light stimulus	http://purl.obolibrary.org/obo/GO_0009582	detection of abiotic stimulus		The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0009584	detection of visible light	http://purl.obolibrary.org/obo/GO_0009583	detection of light stimulus		The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
http://purl.obolibrary.org/obo/GO_0009612	response to mechanical stimulus	http://purl.obolibrary.org/obo/GO_0009605	response to external stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
http://purl.obolibrary.org/obo/GO_0009628	response to abiotic stimulus	http://purl.obolibrary.org/obo/GO_0050896	response to stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.
http://purl.obolibrary.org/obo/GO_0010256	endomembrane system organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
http://purl.obolibrary.org/obo/GO_0010324	membrane invagination	http://purl.obolibrary.org/obo/GO_0061024	membrane organization		The infolding of a membrane.
http://purl.obolibrary.org/obo/GO_0010469	regulation of signaling receptor activity	http://purl.obolibrary.org/obo/GO_0065009	regulation of molecular function		Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.
http://purl.obolibrary.org/obo/GO_0010564	regulation of cell cycle process	http://purl.obolibrary.org/obo/GO_0051726	regulation of cell cycle		Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
http://purl.obolibrary.org/obo/GO_0010565	regulation of ketone metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
http://purl.obolibrary.org/obo/GO_0010608	post-transcriptional regulation of gene expression	http://purl.obolibrary.org/obo/GO_0010468	regulation of gene expression		Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
http://purl.obolibrary.org/obo/GO_0010629	negative regulation of gene expression	http://purl.obolibrary.org/obo/GO_0010558	negative regulation of macromolecule biosynthetic process		Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
http://purl.obolibrary.org/obo/GO_0010876	lipid localization	http://purl.obolibrary.org/obo/GO_0033036	macromolecule localization		Any process in which a lipid is transported to, or maintained in, a specific location.
http://purl.obolibrary.org/obo/GO_0010906	regulation of glucose metabolic process	http://purl.obolibrary.org/obo/GO_0062012	regulation of small molecule metabolic process		Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
http://purl.obolibrary.org/obo/GO_0010962	regulation of glucan biosynthetic process	http://purl.obolibrary.org/obo/GO_0032885	regulation of polysaccharide biosynthetic process		Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.
http://purl.obolibrary.org/obo/GO_0010970	transport along microtubule	http://purl.obolibrary.org/obo/GO_0099111	microtubule-based transport		The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.
http://purl.obolibrary.org/obo/GO_0012505	endomembrane system	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
http://purl.obolibrary.org/obo/GO_0015031	protein transport	http://purl.obolibrary.org/obo/GO_0045184	establishment of protein localization		The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015671	oxygen transport	http://purl.obolibrary.org/obo/GO_0015669	gas transport		The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015718	monocarboxylic acid transport	http://purl.obolibrary.org/obo/GO_0046942	carboxylic acid transport		The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015837	amine transport	http://purl.obolibrary.org/obo/GO_0071705	nitrogen compound transport		The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015850	organic hydroxy compound transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.
http://purl.obolibrary.org/obo/GO_0015925	galactosidase activity	http://purl.obolibrary.org/obo/GO_0004553	hydrolase activity, hydrolyzing O-glycosyl compounds		Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative.
http://purl.obolibrary.org/obo/GO_0015980	energy derivation by oxidation of organic compounds	http://purl.obolibrary.org/obo/GO_0006091	generation of precursor metabolites and energy		The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.
http://purl.obolibrary.org/obo/GO_0016020	membrane	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
http://purl.obolibrary.org/obo/GO_0016043	cellular component organization	http://purl.obolibrary.org/obo/GO_0071840	cellular component organization or biogenesis		A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
http://purl.obolibrary.org/obo/GO_0016160	amylase activity	http://purl.obolibrary.org/obo/GO_0004553	hydrolase activity, hydrolyzing O-glycosyl compounds		Catalysis of the hydrolysis of amylose or an amylose derivative.
http://purl.obolibrary.org/obo/GO_0016192	vesicle-mediated transport	http://purl.obolibrary.org/obo/GO_0009987	cellular process		A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
http://purl.obolibrary.org/obo/GO_0016311	dephosphorylation	http://purl.obolibrary.org/obo/GO_0006796	phosphate-containing compound metabolic process		The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
http://purl.obolibrary.org/obo/GO_0016788	hydrolase activity, acting on ester bonds	http://purl.obolibrary.org/obo/GO_0016787	hydrolase activity		Catalysis of the hydrolysis of any ester bond.
http://purl.obolibrary.org/obo/GO_0016798	hydrolase activity, acting on glycosyl bonds	http://purl.obolibrary.org/obo/GO_0016787	hydrolase activity		Catalysis of the hydrolysis of any glycosyl bond.
http://purl.obolibrary.org/obo/GO_0016885	ligase activity, forming carbon-carbon bonds	http://purl.obolibrary.org/obo/GO_0016874	ligase activity		Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
http://purl.obolibrary.org/obo/GO_0017148	negative regulation of translation	http://purl.obolibrary.org/obo/GO_0051248	negative regulation of protein metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
http://purl.obolibrary.org/obo/GO_0018958	phenol-containing compound metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.
http://purl.obolibrary.org/obo/GO_0019098	reproductive behavior	http://purl.obolibrary.org/obo/GO_0007610	behavior		The specific behavior of an organism that is associated with reproduction.
http://purl.obolibrary.org/obo/GO_0019218	regulation of steroid metabolic process	http://purl.obolibrary.org/obo/GO_0019216	regulation of lipid metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.
http://purl.obolibrary.org/obo/GO_0019219	regulation of nucleobase-containing compound metabolic process	http://purl.obolibrary.org/obo/GO_0080090	regulation of primary metabolic process		Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
http://purl.obolibrary.org/obo/GO_0019318	hexose metabolic process	http://purl.obolibrary.org/obo/GO_0005996	monosaccharide metabolic process		The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
http://purl.obolibrary.org/obo/GO_0019319	hexose biosynthetic process	http://purl.obolibrary.org/obo/GO_0046364	monosaccharide biosynthetic process		The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.
http://purl.obolibrary.org/obo/GO_0019538	protein metabolic process	http://purl.obolibrary.org/obo/GO_0044238	primary metabolic process		The chemical reactions and pathways involving a protein. Includes protein modification.
http://purl.obolibrary.org/obo/GO_0019725	cellular homeostasis	http://purl.obolibrary.org/obo/GO_0042592	homeostatic process		Any process involved in the maintenance of an internal steady state at the level of the cell.
http://purl.obolibrary.org/obo/GO_0019747	regulation of isoprenoid metabolic process	http://purl.obolibrary.org/obo/GO_0019216	regulation of lipid metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.
http://purl.obolibrary.org/obo/GO_0019748	secondary metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.
http://purl.obolibrary.org/obo/GO_0019752	carboxylic acid metabolic process	http://purl.obolibrary.org/obo/GO_0043436	oxoacid metabolic process		The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
http://purl.obolibrary.org/obo/GO_0021700	developmental maturation	http://purl.obolibrary.org/obo/GO_0032502	developmental process		A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.
http://purl.obolibrary.org/obo/GO_0022411	cellular component disassembly	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		A cellular process that results in the breakdown of a cellular component.
http://purl.obolibrary.org/obo/GO_0022857	transmembrane transporter activity	http://purl.obolibrary.org/obo/GO_0005215	transporter activity		Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0030003	intracellular monoatomic cation homeostasis	http://purl.obolibrary.org/obo/GO_0055080	monoatomic cation homeostasis		A homeostatic process involved in the maintenance of a steady state level of monoatomic cations within a cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.
http://purl.obolibrary.org/obo/GO_0030017	sarcomere	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
http://purl.obolibrary.org/obo/GO_0030031	cell projection assembly	http://purl.obolibrary.org/obo/GO_0030030	cell projection organization		Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
http://purl.obolibrary.org/obo/GO_0030054	cell junction	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
http://purl.obolibrary.org/obo/GO_0030262	apoptotic nuclear changes	http://purl.obolibrary.org/obo/GO_0006921	cellular component disassembly involved in execution phase of apoptosis		Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.
http://purl.obolibrary.org/obo/GO_0030312	external encapsulating structure	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
http://purl.obolibrary.org/obo/GO_0030317	flagellated sperm motility	http://purl.obolibrary.org/obo/GO_0060294	cilium movement involved in cell motility		The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
http://purl.obolibrary.org/obo/GO_0030936	transmembrane collagen trimer	http://purl.obolibrary.org/obo/GO_0098797	plasma membrane protein complex		Any collagen trimer that passes through a lipid bilayer membrane.
http://purl.obolibrary.org/obo/GO_0030990	intraciliary transport particle	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
http://purl.obolibrary.org/obo/GO_0031012	extracellular matrix	http://purl.obolibrary.org/obo/GO_0030312	external encapsulating structure		A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
http://purl.obolibrary.org/obo/GO_0031345	negative regulation of cell projection organization	http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization		Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
http://purl.obolibrary.org/obo/GO_0031965	nuclear membrane	http://purl.obolibrary.org/obo/GO_0031090	organelle membrane		Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
http://purl.obolibrary.org/obo/GO_0031966	mitochondrial membrane	http://purl.obolibrary.org/obo/GO_0031090	organelle membrane		Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
http://purl.obolibrary.org/obo/GO_0031967	organelle envelope	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.
http://purl.obolibrary.org/obo/GO_0031974	membrane-enclosed lumen	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
http://purl.obolibrary.org/obo/GO_0032042	mitochondrial DNA metabolic process	http://purl.obolibrary.org/obo/GO_0006259	DNA metabolic process		The chemical reactions and pathways involving mitochondrial DNA.
http://purl.obolibrary.org/obo/GO_0032350	regulation of hormone metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone.
http://purl.obolibrary.org/obo/GO_0032368	regulation of lipid transport	http://purl.obolibrary.org/obo/GO_1905952	regulation of lipid localization		Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0032787	monocarboxylic acid metabolic process	http://purl.obolibrary.org/obo/GO_0019752	carboxylic acid metabolic process		The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
http://purl.obolibrary.org/obo/GO_0033036	macromolecule localization	http://purl.obolibrary.org/obo/GO_0051179	localization		Any process in which a macromolecule is transported to, or maintained in, a specific location.
http://purl.obolibrary.org/obo/GO_0033045	regulation of sister chromatid segregation	http://purl.obolibrary.org/obo/GO_0051983	regulation of chromosome segregation		Any process that modulates the frequency, rate or extent of sister chromatid segregation.
http://purl.obolibrary.org/obo/GO_0034702	monoatomic ion channel complex	http://purl.obolibrary.org/obo/GO_1902495	transmembrane transporter complex		A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective monoatomic ion transport down its electrochemical gradient.
http://purl.obolibrary.org/obo/GO_0034765	regulation of monoatomic ion transmembrane transport	http://purl.obolibrary.org/obo/GO_0043269	regulation of monoatomic ion transport		Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0034982	mitochondrial protein processing	http://purl.obolibrary.org/obo/GO_0016485	protein processing		The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.
http://purl.obolibrary.org/obo/GO_0035082	axoneme assembly	http://purl.obolibrary.org/obo/GO_0022607	cellular component assembly		The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
http://purl.obolibrary.org/obo/GO_0035239	tube morphogenesis	http://purl.obolibrary.org/obo/GO_0009653	anatomical structure morphogenesis		The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
http://purl.obolibrary.org/obo/GO_0035265	organ growth	http://purl.obolibrary.org/obo/GO_0048589	developmental growth		The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.
http://purl.obolibrary.org/obo/GO_0035295	tube development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
http://purl.obolibrary.org/obo/GO_0042044	fluid transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0042180	ketone metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
http://purl.obolibrary.org/obo/GO_0042182	ketone catabolic process	http://purl.obolibrary.org/obo/GO_0044282	small molecule catabolic process		The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
http://purl.obolibrary.org/obo/GO_0042303	molting cycle	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc.
http://purl.obolibrary.org/obo/GO_0042403	thyroid hormone metabolic process	http://purl.obolibrary.org/obo/GO_0042445	hormone metabolic process		The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
http://purl.obolibrary.org/obo/GO_0042430	indole-containing compound metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.
http://purl.obolibrary.org/obo/GO_0042440	pigment metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.
http://purl.obolibrary.org/obo/GO_0042446	hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0042445	hormone metabolic process		The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
http://purl.obolibrary.org/obo/GO_0042578	phosphoric ester hydrolase activity	http://purl.obolibrary.org/obo/GO_0016788	hydrolase activity, acting on ester bonds		Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.
http://purl.obolibrary.org/obo/GO_0043005	neuron projection	http://purl.obolibrary.org/obo/GO_0120025	plasma membrane bounded cell projection		A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
http://purl.obolibrary.org/obo/GO_0043039	tRNA aminoacylation	http://purl.obolibrary.org/obo/GO_0043038	amino acid activation		The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.
http://purl.obolibrary.org/obo/GO_0043066	negative regulation of apoptotic process	http://purl.obolibrary.org/obo/GO_0043069	negative regulation of programmed cell death		Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
http://purl.obolibrary.org/obo/GO_0043085	positive regulation of catalytic activity	http://purl.obolibrary.org/obo/GO_0050790	regulation of catalytic activity		Any process that activates or increases the activity of an enzyme.
http://purl.obolibrary.org/obo/GO_0043086	negative regulation of catalytic activity	http://purl.obolibrary.org/obo/GO_0050790	regulation of catalytic activity		Any process that stops or reduces the activity of an enzyme.
http://purl.obolibrary.org/obo/GO_0043170	macromolecule metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0043231	intracellular membrane-bounded organelle	http://purl.obolibrary.org/obo/GO_0043229	intracellular organelle		Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
http://purl.obolibrary.org/obo/GO_0043244	regulation of protein-containing complex disassembly	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
http://purl.obolibrary.org/obo/GO_0043255	regulation of carbohydrate biosynthetic process	http://purl.obolibrary.org/obo/GO_0009889	regulation of biosynthetic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.
http://purl.obolibrary.org/obo/GO_0043292	contractile muscle fiber	http://purl.obolibrary.org/obo/GO_0099512	supramolecular fiber		Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.
http://purl.obolibrary.org/obo/GO_0043455	regulation of secondary metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.
http://purl.obolibrary.org/obo/GO_0043470	regulation of carbohydrate catabolic process	http://purl.obolibrary.org/obo/GO_0009894	regulation of catabolic process		Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.
http://purl.obolibrary.org/obo/GO_0044042	glucan metabolic process	http://purl.obolibrary.org/obo/GO_0005976	polysaccharide metabolic process		The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues.
http://purl.obolibrary.org/obo/GO_0044060	regulation of endocrine process	http://purl.obolibrary.org/obo/GO_0044057	regulation of system process		Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.
http://purl.obolibrary.org/obo/GO_0044087	regulation of cellular component biogenesis	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
http://purl.obolibrary.org/obo/GO_0044238	primary metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
http://purl.obolibrary.org/obo/GO_0044281	small molecule metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
http://purl.obolibrary.org/obo/GO_0044706	multi-multicellular organism process	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		A multicellular organism process which involves another multicellular organism of the same or different species.
http://purl.obolibrary.org/obo/GO_0045111	intermediate filament cytoskeleton	http://purl.obolibrary.org/obo/GO_0005856	cytoskeleton		Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
http://purl.obolibrary.org/obo/GO_0045132	meiotic chromosome segregation	http://purl.obolibrary.org/obo/GO_1903046	meiotic cell cycle process		The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.
http://purl.obolibrary.org/obo/GO_0045259	proton-transporting ATP synthase complex	http://purl.obolibrary.org/obo/GO_0034703	cation channel complex		A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.
http://purl.obolibrary.org/obo/GO_0045596	negative regulation of cell differentiation	http://purl.obolibrary.org/obo/GO_0045595	regulation of cell differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.
http://purl.obolibrary.org/obo/GO_0045930	negative regulation of mitotic cell cycle	http://purl.obolibrary.org/obo/GO_0045786	negative regulation of cell cycle		Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
http://purl.obolibrary.org/obo/GO_0046883	regulation of hormone secretion	http://purl.obolibrary.org/obo/GO_1903530	regulation of secretion by cell		Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
http://purl.obolibrary.org/obo/GO_0046885	regulation of hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0009889	regulation of biosynthetic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
http://purl.obolibrary.org/obo/GO_0046890	regulation of lipid biosynthetic process	http://purl.obolibrary.org/obo/GO_0009889	regulation of biosynthetic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
http://purl.obolibrary.org/obo/GO_0046907	intracellular transport	http://purl.obolibrary.org/obo/GO_0051641	cellular localization		The directed movement of substances within a cell.
http://purl.obolibrary.org/obo/GO_0046930	pore complex	http://purl.obolibrary.org/obo/GO_0098796	membrane protein complex		A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids.
http://purl.obolibrary.org/obo/GO_0046942	carboxylic acid transport	http://purl.obolibrary.org/obo/GO_0015849	organic acid transport		The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).
http://purl.obolibrary.org/obo/GO_0048193	Golgi vesicle transport	http://purl.obolibrary.org/obo/GO_0016192	vesicle-mediated transport		The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
http://purl.obolibrary.org/obo/GO_0048232	male gamete generation	http://purl.obolibrary.org/obo/GO_0007276	gamete generation		Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.
http://purl.obolibrary.org/obo/GO_0048477	oogenesis	http://purl.obolibrary.org/obo/GO_0007292	female gamete generation		The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
http://purl.obolibrary.org/obo/GO_0048511	rhythmic process	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.
http://purl.obolibrary.org/obo/GO_0048512	circadian behavior	http://purl.obolibrary.org/obo/GO_0007623	circadian rhythm		The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
http://purl.obolibrary.org/obo/GO_0048515	spermatid differentiation	http://purl.obolibrary.org/obo/GO_0030154	cell differentiation		The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
http://purl.obolibrary.org/obo/GO_0048523	negative regulation of cellular process	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
http://purl.obolibrary.org/obo/GO_0048580	regulation of post-embryonic development	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.
http://purl.obolibrary.org/obo/GO_0048609	multicellular organismal reproductive process	http://purl.obolibrary.org/obo/GO_0022414	reproductive process		The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.
http://purl.obolibrary.org/obo/GO_0048873	homeostasis of number of cells within a tissue	http://purl.obolibrary.org/obo/GO_0048872	homeostasis of number of cells		Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
http://purl.obolibrary.org/obo/GO_0050768	negative regulation of neurogenesis	http://purl.obolibrary.org/obo/GO_0050767	regulation of neurogenesis		Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
http://purl.obolibrary.org/obo/GO_0050801	monoatomic ion homeostasis	http://purl.obolibrary.org/obo/GO_0048878	chemical homeostasis		Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
http://purl.obolibrary.org/obo/GO_0050817	coagulation	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The process in which a fluid solution, or part of it, changes into a solid or semisolid mass.
http://purl.obolibrary.org/obo/GO_0050890	cognition	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
http://purl.obolibrary.org/obo/GO_0050896	response to stimulus	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
http://purl.obolibrary.org/obo/GO_0050911	detection of chemical stimulus involved in sensory perception of smell	http://purl.obolibrary.org/obo/GO_0050907	detection of chemical stimulus involved in sensory perception		The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0050953	sensory perception of light stimulus	http://purl.obolibrary.org/obo/GO_0007600	sensory perception		The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
http://purl.obolibrary.org/obo/GO_0050954	sensory perception of mechanical stimulus	http://purl.obolibrary.org/obo/GO_0007600	sensory perception		The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
http://purl.obolibrary.org/obo/GO_0051053	negative regulation of DNA metabolic process	http://purl.obolibrary.org/obo/GO_0045934	negative regulation of nucleobase-containing compound metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.
http://purl.obolibrary.org/obo/GO_0051234	establishment of localization	http://purl.obolibrary.org/obo/GO_0051179	localization		Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
http://purl.obolibrary.org/obo/GO_0051604	protein maturation	http://purl.obolibrary.org/obo/GO_0019538	protein metabolic process		Any process leading to the attainment of the full functional capacity of a protein.
http://purl.obolibrary.org/obo/GO_0051649	establishment of localization in cell	http://purl.obolibrary.org/obo/GO_0051234	establishment of localization		Any process, occurring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
http://purl.obolibrary.org/obo/GO_0051716	cellular response to stimulus	http://purl.obolibrary.org/obo/GO_0009987	cellular process		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
http://purl.obolibrary.org/obo/GO_0051783	regulation of nuclear division	http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization		Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
http://purl.obolibrary.org/obo/GO_0055074	calcium ion homeostasis	http://purl.obolibrary.org/obo/GO_0098771	inorganic ion homeostasis		Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
http://purl.obolibrary.org/obo/GO_0055085	transmembrane transport	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0060004	reflex	http://purl.obolibrary.org/obo/GO_0009605	response to external stimulus		An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness.
http://purl.obolibrary.org/obo/GO_0060047	heart contraction	http://purl.obolibrary.org/obo/GO_0003015	heart process		The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.
http://purl.obolibrary.org/obo/GO_0060079	excitatory postsynaptic potential	http://purl.obolibrary.org/obo/GO_0060078	regulation of postsynaptic membrane potential		A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
http://purl.obolibrary.org/obo/GO_0060089	molecular transducer activity	http://purl.obolibrary.org/obo/GO_0003674	molecular_function		A compound molecular function in which an effector function is controlled by one or more regulatory components.
http://purl.obolibrary.org/obo/GO_0060156	milk ejection reflex	http://purl.obolibrary.org/obo/GO_0032941	secretion by tissue		A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness.
http://purl.obolibrary.org/obo/GO_0060326	cell chemotaxis	http://purl.obolibrary.org/obo/GO_0016477	cell migration		The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
http://purl.obolibrary.org/obo/GO_0060541	respiratory system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.
http://purl.obolibrary.org/obo/GO_0061024	membrane organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
http://purl.obolibrary.org/obo/GO_0061333	renal tubule morphogenesis	http://purl.obolibrary.org/obo/GO_0060562	epithelial tube morphogenesis		The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
http://purl.obolibrary.org/obo/GO_0065003	protein-containing complex assembly	http://purl.obolibrary.org/obo/GO_0043933	protein-containing complex organization		The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
http://purl.obolibrary.org/obo/GO_0070013	intracellular organelle lumen	http://purl.obolibrary.org/obo/GO_0043233	organelle lumen		An organelle lumen that is part of an intracellular organelle.
http://purl.obolibrary.org/obo/GO_0070161	anchoring junction	http://purl.obolibrary.org/obo/GO_0030054	cell junction		A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
http://purl.obolibrary.org/obo/GO_0070192	chromosome organization involved in meiotic cell cycle	http://purl.obolibrary.org/obo/GO_1903046	meiotic cell cycle process		A process of chromosome organization that is involved in a meiotic cell cycle.
http://purl.obolibrary.org/obo/GO_0070288	ferritin complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A protein complex that binds iron and acts as a major iron storage system. There are three major subclasses of ferritins: the classical ferritins (Ftn), the heme-containing bacterioferritins (Bfr) and the DNA-binding proteins from starved cells (Dps). Ftn and Bfr are made of 24 subunits, whereas Dps are smaller with 12 subunits. Ftn is found in most kindoms, while Bfr and Dps are restricted to prokaryotes.
http://purl.obolibrary.org/obo/GO_0070873	regulation of glycogen metabolic process	http://purl.obolibrary.org/obo/GO_0032881	regulation of polysaccharide metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.
http://purl.obolibrary.org/obo/GO_0071705	nitrogen compound transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0071944	cell periphery	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.
http://purl.obolibrary.org/obo/GO_0072359	circulatory system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
http://purl.obolibrary.org/obo/GO_0072378	blood coagulation, fibrin clot formation	http://purl.obolibrary.org/obo/GO_0072376	protein activation cascade		A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.
http://purl.obolibrary.org/obo/GO_0080090	regulation of primary metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
http://purl.obolibrary.org/obo/GO_0090030	regulation of steroid hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0050810	regulation of steroid biosynthetic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.
http://purl.obolibrary.org/obo/GO_0090257	regulation of muscle system process	http://purl.obolibrary.org/obo/GO_0044057	regulation of system process		Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.
http://purl.obolibrary.org/obo/GO_0090304	nucleic acid metabolic process	http://purl.obolibrary.org/obo/GO_0043170	macromolecule metabolic process		Any cellular metabolic process involving nucleic acids.
http://purl.obolibrary.org/obo/GO_0097014	ciliary plasm	http://purl.obolibrary.org/obo/GO_0005737	cytoplasm		All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
http://purl.obolibrary.org/obo/GO_0097194	execution phase of apoptosis	http://purl.obolibrary.org/obo/GO_0009987	cellular process		A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
http://purl.obolibrary.org/obo/GO_0098534	centriole assembly	http://purl.obolibrary.org/obo/GO_0140694	membraneless organelle assembly		A cellular process that results in the assembly of one or more centrioles.
http://purl.obolibrary.org/obo/GO_0098642	network-forming collagen trimer	http://purl.obolibrary.org/obo/GO_0140392	extracellular protein-containing complex		A collagen trimer that forms networks.
http://purl.obolibrary.org/obo/GO_0098643	fibrillar collagen complex	http://purl.obolibrary.org/obo/GO_0098644	complex of collagen trimers		A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands).
http://purl.obolibrary.org/obo/GO_0098645	complex of network-forming collagens	http://purl.obolibrary.org/obo/GO_0098644	complex of collagen trimers		A supramolecular complex that consists of collagen triple helices associated to form a network.
http://purl.obolibrary.org/obo/GO_0098793	presynapse	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The part of a synapse that is part of the presynaptic cell.
http://purl.obolibrary.org/obo/GO_0098798	mitochondrial protein-containing complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A protein complex that is part of a mitochondrion.
http://purl.obolibrary.org/obo/GO_0098802	plasma membrane signaling receptor complex	http://purl.obolibrary.org/obo/GO_0098797	plasma membrane protein complex		Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.
http://purl.obolibrary.org/obo/GO_0098858	actin-based cell projection	http://purl.obolibrary.org/obo/GO_0120025	plasma membrane bounded cell projection		A cell projection supported by an assembly of actin filaments, and which lacks microtubules.
http://purl.obolibrary.org/obo/GO_0098876	vesicle-mediated transport to the plasma membrane	http://purl.obolibrary.org/obo/GO_0051668	localization within membrane		The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.
http://purl.obolibrary.org/obo/GO_0098916	anterograde trans-synaptic signaling	http://purl.obolibrary.org/obo/GO_0099537	trans-synaptic signaling		Cell-cell signaling from pre to post-synapse, across the synaptic cleft.
http://purl.obolibrary.org/obo/GO_0099080	supramolecular complex	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.
http://purl.obolibrary.org/obo/GO_0099500	vesicle fusion to plasma membrane	http://purl.obolibrary.org/obo/GO_0140029	exocytic process		Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.
http://purl.obolibrary.org/obo/GO_0099643	signal release from synapse	http://purl.obolibrary.org/obo/GO_0023061	signal release		Any signal release from a synapse.
http://purl.obolibrary.org/obo/GO_1901135	carbohydrate derivative metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving carbohydrate derivative.
http://purl.obolibrary.org/obo/GO_1901137	carbohydrate derivative biosynthetic process	http://purl.obolibrary.org/obo/GO_0009058	biosynthetic process		The chemical reactions and pathways resulting in the formation of carbohydrate derivative.
http://purl.obolibrary.org/obo/GO_1901568	fatty acid derivative metabolic process	http://purl.obolibrary.org/obo/GO_0006629	lipid metabolic process		The chemical reactions and pathways involving fatty acid derivative.
http://purl.obolibrary.org/obo/GO_1902850	microtubule cytoskeleton organization involved in mitosis	http://purl.obolibrary.org/obo/GO_1903047	mitotic cell cycle process		Any microtubule cytoskeleton organization that is involved in mitosis.
http://purl.obolibrary.org/obo/GO_1903429	regulation of cell maturation	http://purl.obolibrary.org/obo/GO_0060284	regulation of cell development		Any process that modulates the frequency, rate or extent of cell maturation.
http://purl.obolibrary.org/obo/GO_1903509	liposaccharide metabolic process	http://purl.obolibrary.org/obo/GO_1901135	carbohydrate derivative metabolic process		The chemical reactions and pathways involving liposaccharide.
http://purl.obolibrary.org/obo/GO_1903522	regulation of blood circulation	http://purl.obolibrary.org/obo/GO_0044057	regulation of system process		Any process that modulates the frequency, rate or extent of blood circulation.
http://purl.obolibrary.org/obo/GO_1904115	axon cytoplasm	http://purl.obolibrary.org/obo/GO_0120111	neuron projection cytoplasm		Any cytoplasm that is part of a axon.
http://purl.obolibrary.org/obo/GO_2000272	negative regulation of signaling receptor activity	http://purl.obolibrary.org/obo/GO_0044092	negative regulation of molecular function		Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.
http://purl.obolibrary.org/obo/GO_2000831	regulation of steroid hormone secretion	http://purl.obolibrary.org/obo/GO_0046883	regulation of hormone secretion		Any process that modulates the frequency, rate or extent of steroid hormone secretion.
http://purl.obolibrary.org/obo/GO_0045806	negative regulation of endocytosis	http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization		Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
http://purl.obolibrary.org/obo/GO_0045807	positive regulation of endocytosis	http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization		Any process that activates or increases the frequency, rate or extent of endocytosis.
http://purl.obolibrary.org/obo/GO_0045818	negative regulation of glycogen catabolic process	http://purl.obolibrary.org/obo/GO_0009895	negative regulation of catabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.
http://purl.obolibrary.org/obo/GO_0045819	positive regulation of glycogen catabolic process	http://purl.obolibrary.org/obo/GO_0009896	positive regulation of catabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.
http://purl.obolibrary.org/obo/GO_0045829	negative regulation of isotype switching	http://purl.obolibrary.org/obo/GO_0045191	regulation of isotype switching		Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.
http://purl.obolibrary.org/obo/GO_0045830	positive regulation of isotype switching	http://purl.obolibrary.org/obo/GO_0045191	regulation of isotype switching		Any process that activates or increases the frequency, rate or extent of isotype switching.
http://purl.obolibrary.org/obo/GO_0045833	negative regulation of lipid metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.
http://purl.obolibrary.org/obo/GO_0045834	positive regulation of lipid metabolic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.
http://purl.obolibrary.org/obo/GO_0045900	negative regulation of translational elongation	http://purl.obolibrary.org/obo/GO_0017148	negative regulation of translation		Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.
http://purl.obolibrary.org/obo/GO_0045901	positive regulation of translational elongation	http://purl.obolibrary.org/obo/GO_0045727	positive regulation of translation		Any process that activates or increases the frequency, rate or extent of translational elongation.
http://purl.obolibrary.org/obo/GO_0045904	negative regulation of translational termination	http://purl.obolibrary.org/obo/GO_0043242	negative regulation of protein-containing complex disassembly		Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.
http://purl.obolibrary.org/obo/GO_0045905	positive regulation of translational termination	http://purl.obolibrary.org/obo/GO_0045727	positive regulation of translation		Any process that activates or increases the frequency, rate or extent of translational termination.
http://purl.obolibrary.org/obo/GO_0045931	positive regulation of mitotic cell cycle	http://purl.obolibrary.org/obo/GO_0045787	positive regulation of cell cycle		Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
http://purl.obolibrary.org/obo/GO_0045932	negative regulation of muscle contraction	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.
http://purl.obolibrary.org/obo/GO_0045933	positive regulation of muscle contraction	http://purl.obolibrary.org/obo/GO_0051240	positive regulation of multicellular organismal process		Any process that activates or increases the frequency, rate or extent of muscle contraction.
http://purl.obolibrary.org/obo/GO_0045938	positive regulation of circadian sleep/wake cycle, sleep	http://purl.obolibrary.org/obo/GO_0048520	positive regulation of behavior		Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
http://purl.obolibrary.org/obo/GO_0045955	negative regulation of calcium ion-dependent exocytosis	http://purl.obolibrary.org/obo/GO_0017158	regulation of calcium ion-dependent exocytosis		Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis.
http://purl.obolibrary.org/obo/GO_0045956	positive regulation of calcium ion-dependent exocytosis	http://purl.obolibrary.org/obo/GO_0017158	regulation of calcium ion-dependent exocytosis		Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
http://purl.obolibrary.org/obo/GO_0045986	negative regulation of smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006940	regulation of smooth muscle contraction		Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_0045987	positive regulation of smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006940	regulation of smooth muscle contraction		Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_0045992	negative regulation of embryonic development	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.
http://purl.obolibrary.org/obo/GO_0046005	positive regulation of circadian sleep/wake cycle, REM sleep	http://purl.obolibrary.org/obo/GO_0042320	regulation of circadian sleep/wake cycle, REM sleep		Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.
http://purl.obolibrary.org/obo/GO_0046136	positive regulation of vitamin metabolic process	http://purl.obolibrary.org/obo/GO_0030656	regulation of vitamin metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
http://purl.obolibrary.org/obo/GO_0046541	saliva secretion	http://purl.obolibrary.org/obo/GO_0032941	secretion by tissue		The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin.
http://purl.obolibrary.org/obo/GO_0046544	development of animal secondary male sexual characteristics	http://purl.obolibrary.org/obo/GO_0045136	development of animal secondary sexual characteristics		The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male mammals, examples include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.
http://purl.obolibrary.org/obo/GO_0046676	negative regulation of insulin secretion	http://purl.obolibrary.org/obo/GO_0050796	regulation of insulin secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
http://purl.obolibrary.org/obo/GO_0046697	decidualization	http://purl.obolibrary.org/obo/GO_0009888	tissue development		The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
http://purl.obolibrary.org/obo/GO_0046877	regulation of saliva secretion	http://purl.obolibrary.org/obo/GO_0044058	regulation of digestive system process		Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0046878	positive regulation of saliva secretion	http://purl.obolibrary.org/obo/GO_0051047	positive regulation of secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of saliva.
http://purl.obolibrary.org/obo/GO_0048137	spermatocyte division	http://purl.obolibrary.org/obo/GO_0051301	cell division		The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids.
http://purl.obolibrary.org/obo/GO_0048240	sperm capacitation	http://purl.obolibrary.org/obo/GO_0048469	cell maturation		A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
http://purl.obolibrary.org/obo/GO_0048713	regulation of oligodendrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045685	regulation of glial cell differentiation		Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation.
http://purl.obolibrary.org/obo/GO_0048714	positive regulation of oligodendrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045687	positive regulation of glial cell differentiation		Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.
http://purl.obolibrary.org/obo/GO_0048715	negative regulation of oligodendrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045686	negative regulation of glial cell differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.
http://purl.obolibrary.org/obo/GO_0050708	regulation of protein secretion	http://purl.obolibrary.org/obo/GO_0051223	regulation of protein transport		Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.
http://purl.obolibrary.org/obo/GO_0050709	negative regulation of protein secretion	http://purl.obolibrary.org/obo/GO_0051224	negative regulation of protein transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
http://purl.obolibrary.org/obo/GO_0050764	regulation of phagocytosis	http://purl.obolibrary.org/obo/GO_0030100	regulation of endocytosis		Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
http://purl.obolibrary.org/obo/GO_0050765	negative regulation of phagocytosis	http://purl.obolibrary.org/obo/GO_0050764	regulation of phagocytosis		Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
http://purl.obolibrary.org/obo/GO_0050766	positive regulation of phagocytosis	http://purl.obolibrary.org/obo/GO_0050764	regulation of phagocytosis		Any process that activates or increases the frequency, rate or extent of phagocytosis.
http://purl.obolibrary.org/obo/GO_0050882	voluntary musculoskeletal movement	http://purl.obolibrary.org/obo/GO_0050881	musculoskeletal movement		The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will.
http://purl.obolibrary.org/obo/GO_0050885	neuromuscular process controlling balance	http://purl.obolibrary.org/obo/GO_0050905	neuromuscular process		Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.
http://purl.obolibrary.org/obo/GO_0050906	detection of stimulus involved in sensory perception	http://purl.obolibrary.org/obo/GO_0051606	detection of stimulus		The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0050907	detection of chemical stimulus involved in sensory perception	http://purl.obolibrary.org/obo/GO_0009593	detection of chemical stimulus		The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception.
http://purl.obolibrary.org/obo/GO_0050908	detection of light stimulus involved in visual perception	http://purl.obolibrary.org/obo/GO_0050962	detection of light stimulus involved in sensory perception		The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0050909	sensory perception of taste	http://purl.obolibrary.org/obo/GO_0007606	sensory perception of chemical stimulus		The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.
http://purl.obolibrary.org/obo/GO_0050957	equilibrioception	http://purl.obolibrary.org/obo/GO_0007600	sensory perception		The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.
http://purl.obolibrary.org/obo/GO_0050962	detection of light stimulus involved in sensory perception	http://purl.obolibrary.org/obo/GO_0050906	detection of stimulus involved in sensory perception		The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.
http://purl.obolibrary.org/obo/GO_0050966	detection of mechanical stimulus involved in sensory perception of pain	http://purl.obolibrary.org/obo/GO_0050974	detection of mechanical stimulus involved in sensory perception		The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0050968	detection of chemical stimulus involved in sensory perception of pain	http://purl.obolibrary.org/obo/GO_0050907	detection of chemical stimulus involved in sensory perception		The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0050973	detection of mechanical stimulus involved in equilibrioception	http://purl.obolibrary.org/obo/GO_0050974	detection of mechanical stimulus involved in sensory perception		The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears.
http://purl.obolibrary.org/obo/GO_0050974	detection of mechanical stimulus involved in sensory perception	http://purl.obolibrary.org/obo/GO_0050982	detection of mechanical stimulus		The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception.
http://purl.obolibrary.org/obo/GO_0050975	sensory perception of touch	http://purl.obolibrary.org/obo/GO_0050954	sensory perception of mechanical stimulus		The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach).
http://purl.obolibrary.org/obo/GO_0050976	detection of mechanical stimulus involved in sensory perception of touch	http://purl.obolibrary.org/obo/GO_0050974	detection of mechanical stimulus involved in sensory perception		The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0051325	interphase	http://purl.obolibrary.org/obo/GO_0022403	cell cycle phase		The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.
http://purl.obolibrary.org/obo/GO_0051355	proprioception involved in equilibrioception	http://purl.obolibrary.org/obo/GO_0019230	proprioception		The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity.
http://purl.obolibrary.org/obo/GO_0051458	corticotropin secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus.
http://purl.obolibrary.org/obo/GO_0051459	regulation of corticotropin secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.
http://purl.obolibrary.org/obo/GO_0051460	negative regulation of corticotropin secretion	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell.
http://purl.obolibrary.org/obo/GO_0051461	positive regulation of corticotropin secretion	http://purl.obolibrary.org/obo/GO_0090277	positive regulation of peptide hormone secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell.
http://purl.obolibrary.org/obo/GO_0051560	mitochondrial calcium ion homeostasis	http://purl.obolibrary.org/obo/GO_0006874	intracellular calcium ion homeostasis		Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
http://purl.obolibrary.org/obo/GO_0051588	regulation of neurotransmitter transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051589	negative regulation of neurotransmitter transport	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051595	response to methylglyoxal	http://purl.obolibrary.org/obo/GO_1901654	response to ketone		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.
http://purl.obolibrary.org/obo/GO_0051596	methylglyoxal catabolic process	http://purl.obolibrary.org/obo/GO_0140041	cellular detoxification of methylglyoxal		The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
http://purl.obolibrary.org/obo/GO_0051641	cellular localization	http://purl.obolibrary.org/obo/GO_0051179	localization		A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.
http://purl.obolibrary.org/obo/GO_0051709	regulation of killing of cells of another organism	http://purl.obolibrary.org/obo/GO_0035821	modulation of process of another organism		Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism.
http://purl.obolibrary.org/obo/GO_0051711	negative regulation of killing of cells of another organism	http://purl.obolibrary.org/obo/GO_0031342	negative regulation of cell killing		Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism.
http://purl.obolibrary.org/obo/GO_0051712	positive regulation of killing of cells of another organism	http://purl.obolibrary.org/obo/GO_0043068	positive regulation of programmed cell death		Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism.
http://purl.obolibrary.org/obo/GO_0051784	negative regulation of nuclear division	http://purl.obolibrary.org/obo/GO_0010639	negative regulation of organelle organization		Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
http://purl.obolibrary.org/obo/GO_0051785	positive regulation of nuclear division	http://purl.obolibrary.org/obo/GO_0010638	positive regulation of organelle organization		Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.
http://purl.obolibrary.org/obo/GO_0051917	regulation of fibrinolysis	http://purl.obolibrary.org/obo/GO_0030193	regulation of blood coagulation		Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
http://purl.obolibrary.org/obo/GO_0051918	negative regulation of fibrinolysis	http://purl.obolibrary.org/obo/GO_0048519	negative regulation of biological process		Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
http://purl.obolibrary.org/obo/GO_0051919	positive regulation of fibrinolysis	http://purl.obolibrary.org/obo/GO_0030195	negative regulation of blood coagulation		Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
http://purl.obolibrary.org/obo/GO_0051931	regulation of sensory perception	http://purl.obolibrary.org/obo/GO_0031644	regulation of nervous system process		Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.
http://purl.obolibrary.org/obo/GO_0051984	positive regulation of chromosome segregation	http://purl.obolibrary.org/obo/GO_0090068	positive regulation of cell cycle process		Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
http://purl.obolibrary.org/obo/GO_0060456	positive regulation of digestive system process	http://purl.obolibrary.org/obo/GO_0044058	regulation of digestive system process		Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
http://purl.obolibrary.org/obo/GO_0061138	morphogenesis of a branching epithelium	http://purl.obolibrary.org/obo/GO_0002009	morphogenesis of an epithelium		The process in which the anatomical structures of a branched epithelium are generated and organized.
http://purl.obolibrary.org/obo/GO_0065007	biological regulation	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process that modulates a measurable attribute of any biological process, quality or function.
http://purl.obolibrary.org/obo/GO_0070201	regulation of establishment of protein localization	http://purl.obolibrary.org/obo/GO_0032880	regulation of protein localization		Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
http://purl.obolibrary.org/obo/GO_0090278	negative regulation of peptide hormone secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
http://purl.obolibrary.org/obo/GO_0099569	presynaptic cytoskeleton	http://purl.obolibrary.org/obo/GO_0005856	cytoskeleton		The portion of the cytoskeleton contained within the presynapse.
http://purl.obolibrary.org/obo/GO_1901570	fatty acid derivative biosynthetic process	http://purl.obolibrary.org/obo/GO_1901568	fatty acid derivative metabolic process		The chemical reactions and pathways resulting in the formation of fatty acid derivative.
http://purl.obolibrary.org/obo/GO_1903034	regulation of response to wounding	http://purl.obolibrary.org/obo/GO_0080134	regulation of response to stress		Any process that modulates the frequency, rate or extent of response to wounding.
http://purl.obolibrary.org/obo/GO_1903035	negative regulation of response to wounding	http://purl.obolibrary.org/obo/GO_0048585	negative regulation of response to stimulus		Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding.
http://purl.obolibrary.org/obo/GO_1903036	positive regulation of response to wounding	http://purl.obolibrary.org/obo/GO_0048584	positive regulation of response to stimulus		Any process that activates or increases the frequency, rate or extent of response to wounding.
http://purl.obolibrary.org/obo/GO_1903037	regulation of leukocyte cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0022407	regulation of cell-cell adhesion		Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion.
http://purl.obolibrary.org/obo/GO_1903038	negative regulation of leukocyte cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0022408	negative regulation of cell-cell adhesion		Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.
http://purl.obolibrary.org/obo/GO_1903039	positive regulation of leukocyte cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0022409	positive regulation of cell-cell adhesion		Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.
http://purl.obolibrary.org/obo/GO_1903523	negative regulation of blood circulation	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.
http://purl.obolibrary.org/obo/GO_1903524	positive regulation of blood circulation	http://purl.obolibrary.org/obo/GO_0051240	positive regulation of multicellular organismal process		Any process that activates or increases the frequency, rate or extent of blood circulation.
http://purl.obolibrary.org/obo/GO_1904950	negative regulation of establishment of protein localization	http://purl.obolibrary.org/obo/GO_0048519	negative regulation of biological process		Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.
http://purl.obolibrary.org/obo/GO_1904951	positive regulation of establishment of protein localization	http://purl.obolibrary.org/obo/GO_0048518	positive regulation of biological process		Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
http://purl.obolibrary.org/obo/GO_2000832	negative regulation of steroid hormone secretion	http://purl.obolibrary.org/obo/GO_0046888	negative regulation of hormone secretion		Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion.
http://purl.obolibrary.org/obo/GO_2000833	positive regulation of steroid hormone secretion	http://purl.obolibrary.org/obo/GO_0046887	positive regulation of hormone secretion		Any process that activates or increases the frequency, rate or extent of steroid hormone secretion.
http://purl.obolibrary.org/obo/GO_1903770	negative regulation of beta-galactosidase activity	http://purl.obolibrary.org/obo/GO_0051346	negative regulation of hydrolase activity		Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity.
http://purl.obolibrary.org/obo/GO_1903771	positive regulation of beta-galactosidase activity	http://purl.obolibrary.org/obo/GO_0051345	positive regulation of hydrolase activity		Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity.
http://purl.obolibrary.org/obo/GO_1903941	negative regulation of respiratory gaseous exchange	http://purl.obolibrary.org/obo/GO_0043576	regulation of respiratory gaseous exchange		Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange.
http://purl.obolibrary.org/obo/GO_1903942	positive regulation of respiratory gaseous exchange	http://purl.obolibrary.org/obo/GO_0043576	regulation of respiratory gaseous exchange		Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange.
http://purl.obolibrary.org/obo/GO_1903999	negative regulation of eating behavior	http://purl.obolibrary.org/obo/GO_1903998	regulation of eating behavior		Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior.
http://purl.obolibrary.org/obo/GO_1904000	positive regulation of eating behavior	http://purl.obolibrary.org/obo/GO_1903998	regulation of eating behavior		Any process that activates or increases the frequency, rate or extent of eating behavior.
http://purl.obolibrary.org/obo/GO_1904057	negative regulation of sensory perception of pain	http://purl.obolibrary.org/obo/GO_0051930	regulation of sensory perception of pain		Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain.
http://purl.obolibrary.org/obo/GO_1904058	positive regulation of sensory perception of pain	http://purl.obolibrary.org/obo/GO_0051930	regulation of sensory perception of pain		Any process that activates or increases the frequency, rate or extent of sensory perception of pain.
http://purl.obolibrary.org/obo/GO_1904098	regulation of protein O-linked glycosylation	http://purl.obolibrary.org/obo/GO_0010559	regulation of glycoprotein biosynthetic process		Any process that modulates the frequency, rate or extent of protein O-linked glycosylation.
http://purl.obolibrary.org/obo/GO_1904099	negative regulation of protein O-linked glycosylation	http://purl.obolibrary.org/obo/GO_0010561	negative regulation of glycoprotein biosynthetic process		Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation.
http://purl.obolibrary.org/obo/GO_1904100	positive regulation of protein O-linked glycosylation	http://purl.obolibrary.org/obo/GO_0010560	positive regulation of glycoprotein biosynthetic process		Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.
http://purl.obolibrary.org/obo/GO_1904170	regulation of bleb assembly	http://purl.obolibrary.org/obo/GO_0120032	regulation of plasma membrane bounded cell projection assembly		Any process that modulates the frequency, rate or extent of bleb assembly.
http://purl.obolibrary.org/obo/GO_1904171	negative regulation of bleb assembly	http://purl.obolibrary.org/obo/GO_0120033	negative regulation of plasma membrane bounded cell projection assembly		Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly.
http://purl.obolibrary.org/obo/GO_1904172	positive regulation of bleb assembly	http://purl.obolibrary.org/obo/GO_0120034	positive regulation of plasma membrane bounded cell projection assembly		Any process that activates or increases the frequency, rate or extent of bleb assembly.
http://purl.obolibrary.org/obo/GO_1904304	regulation of gastro-intestinal system smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006940	regulation of smooth muscle contraction		Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_1904305	negative regulation of gastro-intestinal system smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904304	regulation of gastro-intestinal system smooth muscle contraction		Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_1904306	positive regulation of gastro-intestinal system smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904304	regulation of gastro-intestinal system smooth muscle contraction		Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_1904347	regulation of small intestine smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904304	regulation of gastro-intestinal system smooth muscle contraction		Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_1904348	negative regulation of small intestine smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904347	regulation of small intestine smooth muscle contraction		Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_1904349	positive regulation of small intestine smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904347	regulation of small intestine smooth muscle contraction		Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_1904362	regulation of calcitonin secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that modulates the frequency, rate or extent of calcitonin secretion.
http://purl.obolibrary.org/obo/GO_1904363	negative regulation of calcitonin secretion	http://purl.obolibrary.org/obo/GO_1904362	regulation of calcitonin secretion		Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion.
http://purl.obolibrary.org/obo/GO_1904364	positive regulation of calcitonin secretion	http://purl.obolibrary.org/obo/GO_0090277	positive regulation of peptide hormone secretion		Any process that activates or increases the frequency, rate or extent of calcitonin secretion.
http://purl.obolibrary.org/obo/GO_1904409	regulation of secretory granule organization	http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization		Any process that modulates the frequency, rate or extent of secretory granule organization.
http://purl.obolibrary.org/obo/GO_1904410	negative regulation of secretory granule organization	http://purl.obolibrary.org/obo/GO_0010639	negative regulation of organelle organization		Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization.
http://purl.obolibrary.org/obo/GO_1904411	positive regulation of secretory granule organization	http://purl.obolibrary.org/obo/GO_0010638	positive regulation of organelle organization		Any process that activates or increases the frequency, rate or extent of secretory granule organization.
http://purl.obolibrary.org/obo/GO_1904478	regulation of intestinal absorption	http://purl.obolibrary.org/obo/GO_0044058	regulation of digestive system process		Any process that modulates the frequency, rate or extent of intestinal absorption.
http://purl.obolibrary.org/obo/GO_1904479	negative regulation of intestinal absorption	http://purl.obolibrary.org/obo/GO_0060457	negative regulation of digestive system process		Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption.
http://purl.obolibrary.org/obo/GO_1904480	positive regulation of intestinal absorption	http://purl.obolibrary.org/obo/GO_1904478	regulation of intestinal absorption		Any process that activates or increases the frequency, rate or extent of intestinal absorption.
http://purl.obolibrary.org/obo/GO_1904675	regulation of somatic stem cell division	http://purl.obolibrary.org/obo/GO_2000035	regulation of stem cell division		Any process that modulates the frequency, rate or extent of somatic stem cell division.
http://purl.obolibrary.org/obo/GO_1904676	negative regulation of somatic stem cell division	http://purl.obolibrary.org/obo/GO_0051782	negative regulation of cell division		Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division.
http://purl.obolibrary.org/obo/GO_1904677	positive regulation of somatic stem cell division	http://purl.obolibrary.org/obo/GO_0051781	positive regulation of cell division		Any process that activates or increases the frequency, rate or extent of somatic stem cell division.
http://purl.obolibrary.org/obo/GO_1905082	regulation of mitochondrial translational elongation	http://purl.obolibrary.org/obo/GO_0006448	regulation of translational elongation		Any process that modulates the frequency, rate or extent of mitochondrial translational elongation.
http://purl.obolibrary.org/obo/GO_1905083	negative regulation of mitochondrial translational elongation	http://purl.obolibrary.org/obo/GO_0070130	negative regulation of mitochondrial translation		Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation.
http://purl.obolibrary.org/obo/GO_1905084	positive regulation of mitochondrial translational elongation	http://purl.obolibrary.org/obo/GO_1905082	regulation of mitochondrial translational elongation		Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation.
http://purl.obolibrary.org/obo/GO_1905213	negative regulation of mitotic chromosome condensation	http://purl.obolibrary.org/obo/GO_0010948	negative regulation of cell cycle process		Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation.
http://purl.obolibrary.org/obo/GO_1905277	negative regulation of epithelial tube formation	http://purl.obolibrary.org/obo/GO_1905276	regulation of epithelial tube formation		Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation.
http://purl.obolibrary.org/obo/GO_1905503	regulation of motile cilium assembly	http://purl.obolibrary.org/obo/GO_1902017	regulation of cilium assembly		Any process that modulates the frequency, rate or extent of motile cilium assembly.
http://purl.obolibrary.org/obo/GO_1905504	negative regulation of motile cilium assembly	http://purl.obolibrary.org/obo/GO_1902018	negative regulation of cilium assembly		Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly.
http://purl.obolibrary.org/obo/GO_1905505	positive regulation of motile cilium assembly	http://purl.obolibrary.org/obo/GO_0045724	positive regulation of cilium assembly		Any process that activates or increases the frequency, rate or extent of motile cilium assembly.
http://purl.obolibrary.org/obo/GO_1905553	regulation of blood vessel branching	http://purl.obolibrary.org/obo/GO_0060688	regulation of morphogenesis of a branching structure		Any process that modulates the frequency, rate or extent of blood vessel branching.
http://purl.obolibrary.org/obo/GO_1905554	negative regulation of blood vessel branching	http://purl.obolibrary.org/obo/GO_0016525	negative regulation of angiogenesis		Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching.
http://purl.obolibrary.org/obo/GO_1905555	positive regulation of blood vessel branching	http://purl.obolibrary.org/obo/GO_0045766	positive regulation of angiogenesis		Any process that activates or increases the frequency, rate or extent of blood vessel branching.
http://purl.obolibrary.org/obo/GO_1990770	small intestine smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006939	smooth muscle contraction		A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.
http://purl.obolibrary.org/obo/GO_2000035	regulation of stem cell division	http://purl.obolibrary.org/obo/GO_0051302	regulation of cell division		Any process that modulates the frequency, rate or extent of stem cell division.
http://purl.obolibrary.org/obo/GO_2000252	negative regulation of feeding behavior	http://purl.obolibrary.org/obo/GO_0060259	regulation of feeding behavior		Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.
http://purl.obolibrary.org/obo/GO_2000253	positive regulation of feeding behavior	http://purl.obolibrary.org/obo/GO_0060259	regulation of feeding behavior		Any process that activates or increases the frequency, rate or extent of feeding behavior.
http://purl.obolibrary.org/obo/GO_2001222	regulation of neuron migration	http://purl.obolibrary.org/obo/GO_0030334	regulation of cell migration		Any process that modulates the frequency, rate or extent of neuron migration.
http://purl.obolibrary.org/obo/GO_2001223	negative regulation of neuron migration	http://purl.obolibrary.org/obo/GO_0030336	negative regulation of cell migration		Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
http://purl.obolibrary.org/obo/GO_2001224	positive regulation of neuron migration	http://purl.obolibrary.org/obo/GO_0030335	positive regulation of cell migration		Any process that activates or increases the frequency, rate or extent of neuron migration.
http://purl.obolibrary.org/obo/HP_0003961	Fractured forearm bone	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		Bone fracture in the radius, ulna, or wrist.
http://purl.obolibrary.org/obo/HP_0003971	Broad forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		Abnormally wide bone of the skeleton of forearm.
http://purl.obolibrary.org/obo/HP_0003974	Absent radius	http://purl.obolibrary.org/obo/HP_0006501	Aplasia/Hypoplasia of the radius		Missing radius bone associated with congenital failure of development.
http://purl.obolibrary.org/obo/HP_0003981	Broad radius	http://purl.obolibrary.org/obo/HP_0005622	Broad long bones		Increased width of the radius.
http://purl.obolibrary.org/obo/HP_0003982	Aplasia of the ulna	http://purl.obolibrary.org/obo/HP_0006495	Aplasia/Hypoplasia of the ulna		Missing ulna bone associated with congenital failure of development.
http://purl.obolibrary.org/obo/HP_0003988	Long ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Increased length of the ulna.
http://purl.obolibrary.org/obo/HP_0003991	Osteosclerosis of the ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Osteosclerosis (increased density related to increased bone mass) of the ulna.
http://purl.obolibrary.org/obo/HP_0003992	Slender ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Reduction in diameter of the ulna.
http://purl.obolibrary.org/obo/HP_0003993	Broad ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Increased width of the ulna.
http://purl.obolibrary.org/obo/HP_0003994	Dislocated wrist	http://purl.obolibrary.org/obo/HP_0025799	Abnormal wrist physiology		An injury of the wrist with displacement of any of the eight carpal bones.
http://purl.obolibrary.org/obo/HP_0004000	Cone-shaped distal radial epiphysis	http://purl.obolibrary.org/obo/HP_0010579	Cone-shaped epiphysis		The distal epiphysis (rounded portion of bone at the far end of the radius distal to the growth plate) has an abnormal cone-shaped appearance.
http://purl.obolibrary.org/obo/HP_0004012	Premature fusion of the radial epiphyseal plates	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		A premature fusion of the epiphyseal plates of the radius. Epiphyseal plates are located at the distal and proximal ends of the long bones, in this case of the radius and premature fusion will have an effect on the growh of the radial bone, inhibiting or at least disturbing the normal growth and development of the bone.
http://purl.obolibrary.org/obo/HP_0004014	Broad radial epiphyseal plate	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		Abnormal increase in width of the epiphyseal growth plate of the radius.
http://purl.obolibrary.org/obo/HP_0004018	Flared radial metaphysis	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		The presence of a splayed (i.e.,flared) metaphyseal segment of the radius.
http://purl.obolibrary.org/obo/HP_0004019	Radial metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		Irregularity of the normally smooth surface of the metaphysis of the radius.
http://purl.obolibrary.org/obo/HP_0004026	Broad radial metaphysis	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		Increase in width (breadth) of the radial metaphysis.
http://purl.obolibrary.org/obo/HP_0004027	Abnormality of radial diaphysis	http://purl.obolibrary.org/obo/HP_0009808	Anomaly of the upper limb diaphyses		An anomaly of the radial diaphysis.
http://purl.obolibrary.org/obo/HP_0004031	Broad radial diaphysis	http://purl.obolibrary.org/obo/HP_0004027	Abnormality of radial diaphysis		Increase in width of the diaphysis of radius.
http://purl.obolibrary.org/obo/HP_0004032	Abnormal olecranon morphology	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Any structural abnormality of the olecranon, a bony eminence of the proximal ulna.
http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Any structural abnormality of the portion of the ulna between the epiphysis and the diaphysis.
http://purl.obolibrary.org/obo/HP_0004042	Ulnar metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology		Irregularity of the normally smooth surface of the metaphysis of the ulna.
http://purl.obolibrary.org/obo/HP_0004045	Sloping ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology		A sloped configuration of the metaphysis (shaft) of the ulna.
http://purl.obolibrary.org/obo/HP_0004047	Wide ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology		Increase in width (breadth) of the ulnar metaphysis.
http://purl.obolibrary.org/obo/HP_0004050	Absent hand	http://purl.obolibrary.org/obo/HP_6000918	Transverse terminal upper limb defect		The total absence of the hand, with no bony elements distal to the radius or ulna.
http://purl.obolibrary.org/obo/HP_0004051	Advanced ossification of the hand bones	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		Ossification of hand bones at an earlier age than normal.
http://purl.obolibrary.org/obo/HP_0004052	Delayed ossification of the hand bones	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		Ossification of hand bones is less advanced than would be expected according to age-adjusted norms.
http://purl.obolibrary.org/obo/HP_0004053	Dysharmonic maturation of the hand bones	http://purl.obolibrary.org/obo/HP_0200000	Dysharmonic skeletal maturation		Pattern of hand-wrist development does not fit the normal sequence of ossification of the individual bones of the hand.
http://purl.obolibrary.org/obo/HP_0004054	Sclerosis of hand bone	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Osteosclerosis affecting one or more bones of the hand.
http://purl.obolibrary.org/obo/HP_0004057	Mitten deformity	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		Fusion of the hands and feet by a thin membrane of skin (scarring) seen in forms of dystrophic epidermolysis bullosa and leading to a "mitten" hand deformity.
http://purl.obolibrary.org/obo/HP_0004060	Trident hand	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		A hand in which the fingers are of nearly equal length and deflected at the first interphalangeal joint, so as to give a forklike shape consisting of separation of the first and second as well as the third and fourth digits.
http://purl.obolibrary.org/obo/HP_0004097	Deviation of finger	http://purl.obolibrary.org/obo/HP_0009484	Deviation of the hand or of fingers of the hand		Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges.
http://purl.obolibrary.org/obo/HP_0004099	Macrodactyly	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		Significant increase in the length and girth of most or all of a digit compared to its contralateral digit (if unaffected) or compared to what would be expected for age/body build. The increased girth is accompanied by an increase in the dorso-ventral dimension AND the lateral dimension of the digit.
http://purl.obolibrary.org/obo/HP_0004100	Abnormal 2nd finger morphology	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		An anomaly of the second finger, also known as the index finger.
http://purl.obolibrary.org/obo/HP_0004112	Midline nasal groove	http://purl.obolibrary.org/obo/HP_0004122	Midline defect of the nose		An abnormal groove on the midline of the nose that may extend to the nasal tip.
http://purl.obolibrary.org/obo/HP_0004122	Midline defect of the nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		This term groups together three conditions that presumably represent different degrees of severity of a midline defect of the nose or nasal tip.
http://purl.obolibrary.org/obo/HP_0004132	Dimple on nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		An abnormal indentation of the skin in the region of the nasal tip.
http://purl.obolibrary.org/obo/HP_0004150	Abnormal 3rd finger morphology	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		An anomaly of the third finger.
http://purl.obolibrary.org/obo/HP_0004180	Short distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009882	Short distal phalanx of finger		Hypoplasia (congenital reduction in size) of the distal phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0004195	Osteolytic defects of the phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009771	Osteolytic defects of the phalanges of the hand		Osteolytic defects of the phalanges of the 4th (ring) finger.
http://purl.obolibrary.org/obo/HP_0004197	Fourth finger symphalangism	http://purl.obolibrary.org/obo/HP_0009172	Abnormal 4th finger phalanx morphology		Congenital bony fusion of two adjacent phalanges of the fourth finger.
http://purl.obolibrary.org/obo/HP_0004209	Clinodactyly of the 5th finger	http://purl.obolibrary.org/obo/HP_0040019	Finger clinodactyly		Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger).
http://purl.obolibrary.org/obo/HP_0004213	Abnormal 5th finger phalanx morphology	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Abnormality of the phalanges of the 5th (little) finger.
http://purl.obolibrary.org/obo/HP_0004214	Curved phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009770	Curved phalanges of the hand		Curved phalanges of the 5th (little) finger.
http://purl.obolibrary.org/obo/HP_0004216	Osteolytic defects of the phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009771	Osteolytic defects of the phalanges of the hand		Dissolution or degeneration of bone tissue of the phalanges of the 5th finger.
http://purl.obolibrary.org/obo/HP_0004218	Fifth finger symphalangism	http://purl.obolibrary.org/obo/HP_0004213	Abnormal 5th finger phalanx morphology		Congenital bony fusion of two adjacent phalanges of the fifth finger.
http://purl.obolibrary.org/obo/HP_0004220	Short middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009370	Type A brachydactyly		Hypoplastic/small middle phalanx of the fifth finger.
http://purl.obolibrary.org/obo/HP_0004222	Cone-shaped epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010248	Cone-shaped epiphyses of the distal phalanges of the hand		A cone-shaped appearance of the epiphysis of the distal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0004223	Ivory epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010252	Ivory epiphyses of the distal phalanges of the hand		Sclerosis of the epiphysis of the distal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0004224	Abnormality of the epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		Abnormality of the epiphysis of the middle phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0004225	Abnormality of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0004213	Abnormal 5th finger phalanx morphology		Abnormality of the distal phalanx of the 5th (little) finger.
http://purl.obolibrary.org/obo/HP_0004226	Curved distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009838	Curved distal phalanges of the hand		Curved appearance of the distal phalanx of the 5th (little) finger.
http://purl.obolibrary.org/obo/HP_0004227	Short distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009882	Short distal phalanx of finger		Hypoplastic/small distal phalanx of the fifth finger.
http://purl.obolibrary.org/obo/HP_0004230	Subluxation of the proximal interphalangeal joint of the little finger	http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation		A partial dislocation of the proximal interphalangeal joint of the little finger.
http://purl.obolibrary.org/obo/HP_0004231	Carpal bone aplasia	http://purl.obolibrary.org/obo/HP_0006502	Aplasia/Hypoplasia involving the carpal bones		Congenital absence of a carpal bone.
http://purl.obolibrary.org/obo/HP_0004232	Accessory carpal bones	http://purl.obolibrary.org/obo/HP_0004275	Duplication of hand bones		The presence of more than the normal number of carpal bones.
http://purl.obolibrary.org/obo/HP_0004233	Advanced ossification of carpal bones	http://purl.obolibrary.org/obo/HP_0006257	Abnormality of carpal bone ossification		Ossification of carpal bones at an abnormally early age.
http://purl.obolibrary.org/obo/HP_0004234	Bone-in-a-bone appearance of carpal bones	http://purl.obolibrary.org/obo/HP_0009164	Abnormal calcification of the carpal bones		The bone-in-bone sign is a radiographic finding produced by increased sclerosis (abnormally dense bone) occurring intermittently with zones of relatively normal bone density. This term should be used to describe such a finding in the carpal bones.
http://purl.obolibrary.org/obo/HP_0004236	Irregular carpal bones	http://purl.obolibrary.org/obo/HP_0006014	Abnormally shaped carpal bones		Carpal bones with irregular or fragmented margins.
http://purl.obolibrary.org/obo/HP_0004237	Large carpal bones	http://purl.obolibrary.org/obo/HP_0006014	Abnormally shaped carpal bones		Increased size of carpal bones.
http://purl.obolibrary.org/obo/HP_0004241	Stippled calcification in carpal bones	http://purl.obolibrary.org/obo/HP_0009164	Abnormal calcification of the carpal bones		Point-shaped (punctate) calcifications affecting the carpal bones.
http://purl.obolibrary.org/obo/HP_0004243	Abnormal scaphoid morphology	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		Any structural anomaly of the scaphoid. The scaphoid is the largest bone of the proximal row of carpal bones. It is located on the same side as the thumb.
http://purl.obolibrary.org/obo/HP_0004244	Accessory scaphoid	http://purl.obolibrary.org/obo/HP_0004243	Abnormal scaphoid morphology		Variations in the development of carpal bones are uncommon, with the scaphoid bone typically forming from the fusion of the os centrale carpi and the radial chondrification center during embryogenesis. A bipartite scaphoid is a rare congenital disorder that occurs when these ossification centers fail to fuse.
http://purl.obolibrary.org/obo/HP_0004246	Delayed ossification of the scaphoid	http://purl.obolibrary.org/obo/HP_0045003	Abnormal ossification of the scaphoid		Formation of bone tissue of scaphoid is less than expected for age.
http://purl.obolibrary.org/obo/HP_0004247	Small scaphoid	http://purl.obolibrary.org/obo/HP_0004243	Abnormal scaphoid morphology		Underdevelopment of the scaphoid.
http://purl.obolibrary.org/obo/HP_0004248	Abnormal lunate bone morphology	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		Any structural anomaly of the lunate bone, which is located in the proximal row of carpal bones.
http://purl.obolibrary.org/obo/HP_0004251	Lunate-triquetral fusion	http://purl.obolibrary.org/obo/HP_0004248	Abnormal lunate bone morphology		Osseous fusion of the lunate and triquetrum.
http://purl.obolibrary.org/obo/HP_0004252	Abnormal trapezium morphology	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		An anomaly of the trapezium, which is the carpal bone located at the base of the thumb.
http://purl.obolibrary.org/obo/HP_0004254	Delayed ossification of the trapezium	http://purl.obolibrary.org/obo/HP_0045001	Abnormal ossification of the trapezium		Formation of bone tissue of trapezium is less than expected for age.
http://purl.obolibrary.org/obo/HP_0004255	Small trapezium	http://purl.obolibrary.org/obo/HP_0004252	Abnormal trapezium morphology		Underdevelopment of the trapezium.
http://purl.obolibrary.org/obo/HP_0004256	Abnormal trapezoid bone morphology	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		A structural anomaly of the trapezoid bone, which is the smallest bone in the distal row of carpal bones.
http://purl.obolibrary.org/obo/HP_0004257	Delayed ossification of the trapezoid bone	http://purl.obolibrary.org/obo/HP_0045004	Abnormal ossification of the trapezoid bone		Formation of bone tissue of trapezoid is less than expected for age.
http://purl.obolibrary.org/obo/HP_0004258	Small trapezoid bone	http://purl.obolibrary.org/obo/HP_0004256	Abnormal trapezoid bone morphology		Underdevelopment of the trapezoid.
http://purl.obolibrary.org/obo/HP_0004269	Subluxation of the small joints of the hand	http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation		A partial dislocation of some or all of the small joints of the hand.
http://purl.obolibrary.org/obo/HP_0004276	Exostoses of hand bones	http://purl.obolibrary.org/obo/HP_0100777	Exostoses		Abnormal formation of new bone on the surface of a bone of the hand.
http://purl.obolibrary.org/obo/HP_0004278	Synostosis involving bones of the hand	http://purl.obolibrary.org/obo/HP_0100238	Synostosis involving bones of the upper limbs		An abnormal union between bones or parts of bones of the hand.
http://purl.obolibrary.org/obo/HP_0004279	Short palm	http://purl.obolibrary.org/obo/HP_0005927	Aplasia/hypoplasia involving bones of the hand		Short palm.
http://purl.obolibrary.org/obo/HP_0004283	Narrow palm	http://purl.obolibrary.org/obo/HP_0100871	Abnormal palm morphology		For children from birth to 4 years of age, the palm width is more than 2 SD below the mean; for children from 4 to 16 years of age the palm width is below the 5th centile; or, the width of the palm appears disproportionately narrow for its length.
http://purl.obolibrary.org/obo/HP_0004293	Synostosis of second metacarpal-trapezoid	http://purl.obolibrary.org/obo/HP_0100328	Carpometacarpal synostosis		Fusion of the second metacarpal-trapezoid.
http://purl.obolibrary.org/obo/HP_0004294	Subluxation of metacarpal phalangeal joints	http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation		A partial dislocation affecting some or all of the metacarpophalangeal joints.
http://purl.obolibrary.org/obo/HP_0004315	Decreased circulating IgG concentration	http://purl.obolibrary.org/obo/HP_0410242	Abnormal circulating IgG concentration		An abnormally decreased level of immunoglobulin G (IgG) in blood.
http://purl.obolibrary.org/obo/HP_0004319	Decreased circulating aldosterone concentration	http://purl.obolibrary.org/obo/HP_0040085	Abnormal circulating aldosterone concentration		Abnormally reduced levels of aldosterone.
http://purl.obolibrary.org/obo/HP_0004326	Cachexia	http://purl.obolibrary.org/obo/HP_0001824	Weight loss		Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease.
http://purl.obolibrary.org/obo/HP_0004331	Decreased skull ossification	http://purl.obolibrary.org/obo/HP_0011849	Abnormal bone ossification		A reduction in the magnitude or amount of ossification of the skull.
http://purl.obolibrary.org/obo/HP_0004333	Bone-marrow foam cells	http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology		The presence of foam cells in the bone marrow, generally demonstrated by bone-marrow aspiration or biopsy. Foam cells have a vacuolated appearance due to the presence of complex lipid deposits, giving them a foamy or soap-suds appearance.
http://purl.obolibrary.org/obo/HP_0004336	Myelin outfoldings	http://purl.obolibrary.org/obo/HP_0030173	Peripheral hypermyelination		The presence of excessive redundant myelin in the peripheral nerve sheath.
http://purl.obolibrary.org/obo/HP_0004338	Abnormal circulating aromatic amino acid concentration	http://purl.obolibrary.org/obo/HP_0033107	Abnormal circulating proteinogenic amino acid concentration		Any deviation from the normal concentration of aromatic amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004340	Abnormal circulating vitamin B concentration	http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration		The concentration of one or more B vitamins is outside the reference range.
http://purl.obolibrary.org/obo/HP_0004342	Abnormal galactosidase enyzme activity	http://purl.obolibrary.org/obo/HP_0003649	Abnormal glycosidase enzyme activity		Abnormality of galactoside metabolism. A galactoside is a glycoside (a sugar moiety bound to some other moiety) containing galactose.
http://purl.obolibrary.org/obo/HP_0004343	Abnormal glycosphingolipid metabolism	http://purl.obolibrary.org/obo/HP_0010969	Abnormality of glycolipid metabolism		An abnormality of glycosphingolipid metabolism.
http://purl.obolibrary.org/obo/HP_0004348	Abnormality of bone mineral density	http://purl.obolibrary.org/obo/HP_0011849	Abnormal bone ossification		This term applies to all changes in bone mineral density which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone. Changes may affect all bones of the organism, just certain bones or only parts of bones and include decreased mineralisation as may be seen in osteoporosis or increased mineralisation and or ossification as in osteopetrosis, exostoses or any kind of atopic calicfications of different origin and distribution. The overall amount of mineralization of the bone-organ can be measured as the amount of matter per cubic centimeter of bones, usually measured by densitometry of the lumbar spine or hip. The measurements are usually reported as g/cm3 or as a Z-score (the number of standard deviations above or below the mean for the patient's age and sex). Note that measurement with this method does not reflect local changes in other bones, and as such might not be correct with regard the hole bone-organ.
http://purl.obolibrary.org/obo/HP_0004352	Abnormal circulating purines concentration	http://purl.obolibrary.org/obo/HP_0010932	Abnormal circulating nucleobase concentration		Any deviation from the normal concentration of purines in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004375	Neoplasm of the nervous system	http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology		A tumor (abnormal growth of tissue) of the nervous system.
http://purl.obolibrary.org/obo/HP_0004380	Aortic valve calcification	http://purl.obolibrary.org/obo/HP_0005146	Cardiac valve calcification		Deposition of calcium salts in the aortic valve.
http://purl.obolibrary.org/obo/HP_0004381	Supravalvular aortic stenosis	http://purl.obolibrary.org/obo/HP_0031652	Abnormal aortic valve physiology		A pathological narrowing in the region above the aortic valve associated with restricted left ventricular outflow.
http://purl.obolibrary.org/obo/HP_0004382	Mitral valve calcification	http://purl.obolibrary.org/obo/HP_0005146	Cardiac valve calcification		Abnormal calcification of the mitral valve.
http://purl.obolibrary.org/obo/HP_0004383	Hypoplastic left ventricle	http://purl.obolibrary.org/obo/HP_0045017	Congenital malformation of the left heart		A severe congenital heart defect characterized by underdevelopment of the left ventricle.
http://purl.obolibrary.org/obo/HP_0004384	Type I truncus arteriosus	http://purl.obolibrary.org/obo/HP_0001660	Truncus arteriosus		Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with a short pulmonary trunk arises from the truncus arteriosus, giving rise to both pulmonary arteries.
http://purl.obolibrary.org/obo/HP_0004387	Enterocolitis	http://purl.obolibrary.org/obo/HP_0002583	Colitis		An inflammation of the colon and small intestine. However, most conditions are either categorized as Enteritis (inflammation of the small intestine) or Colitis (inflammation of the large intestine).
http://purl.obolibrary.org/obo/HP_0004388	Microcolon	http://purl.obolibrary.org/obo/HP_0100811	Aplasia/Hypoplasia of the colon		A colon of abnormally small caliber.
http://purl.obolibrary.org/obo/HP_0004389	Intestinal pseudo-obstruction	http://purl.obolibrary.org/obo/HP_0002579	Gastrointestinal dysmotility		A functional rather than mechanical obstruction of the intestines, associated with manifestations that resemble those caused by an intestinal obstruction, including distension, abdominal pain, nausea, vomiting, constipation or diarrhea, in an individual in whom a mechanical blockage has been excluded.
http://purl.obolibrary.org/obo/HP_0004390	Hamartomatous polyposis	http://purl.obolibrary.org/obo/HP_0005266	Intestinal polyp		Polyp-like protrusions which are histologically hamartomas. These can occur throughout the gastrointestinal tract. Hamartomatous polyps are composed of the normal cellular elements of the gastrointestinal tract, but have a markedly distorted architecture.
http://purl.obolibrary.org/obo/HP_0004392	Prune belly	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		A kind of congenital defect of the anterior abdominal wall in which the intestines are evident through the thin, lax, and protruding abdominal wall in affected infants.
http://purl.obolibrary.org/obo/HP_0004395	Malnutrition	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		A deficiency in the intake of energy and nutrients.
http://purl.obolibrary.org/obo/HP_0004396	Poor appetite	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		A reduced desire to eat.
http://purl.obolibrary.org/obo/HP_0004399	Congenital pyloric atresia	http://purl.obolibrary.org/obo/HP_0004400	Abnormality of the pylorus		Congenital atresia of the pylorus.
http://purl.obolibrary.org/obo/HP_0004401	Meconium ileus	http://purl.obolibrary.org/obo/HP_0010676	Mechanical ileus		Obstruction of the intestine due to abnormally thick meconium.
http://purl.obolibrary.org/obo/HP_0004409	Hyposmia	http://purl.obolibrary.org/obo/HP_0004408	Abnormality of the sense of smell		A decreased sensitivity to odorants (that is, a decreased ability to perceive odors).
http://purl.obolibrary.org/obo/HP_0004411	Deviated nasal septum	http://purl.obolibrary.org/obo/HP_0000419	Abnormal nasal septum morphology		Positioning of the nasal septum to the right or left in contrast to the normal midline position of the nasal septum.
http://purl.obolibrary.org/obo/HP_0004414	Abnormality of the pulmonary artery	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		An abnormality of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004415	Pulmonary artery stenosis	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		An abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0004417	Intermittent claudication	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Intermittent claudication is a symptom of peripheral arterial occlusive disease. After having walked over a distance which is individually characteristic, the patients experience pain or cramps in the calves, feet or thighs which typically subsides on standing still.
http://purl.obolibrary.org/obo/HP_0004419	Recurrent thrombophlebitis	http://purl.obolibrary.org/obo/HP_0004418	Thrombophlebitis		Repeated episodes of inflammation of a vein associated with venous thrombosis (blood clot formation within the vein).
http://purl.obolibrary.org/obo/HP_0004421	Elevated systolic blood pressure	http://purl.obolibrary.org/obo/HP_0032263	Increased blood pressure		Abnormal increase in systolic blood pressure.
http://purl.obolibrary.org/obo/HP_0004422	Biparietal narrowing	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		A narrowing of the biparietal diameter (i.e., of the transverse distance between the protuberances of the two parietal bones of the skull).
http://purl.obolibrary.org/obo/HP_0004423	Cranium bifidum occultum	http://purl.obolibrary.org/obo/HP_0002084	Encephalocele		Cranium bifidum occultum, also known as Catlin mark, is a congenital midline skull defect presenting as an enlarged posterior fontanelle in the upper posterior angle of the parietal bone close to the intersection of the sagittal and lambdoid sutures. Cranium bifidum occultum occurs due to a defect in intramembranous ossification, a process through which skull bones (frontal, parietal, squamous temporal and occipital bones superior to the mendosal suture) ossify under a vascularized membrane toward the midline to cover the brain. Unlike cranium bifidum cysticum, cranium bifidum occultum does not have herniation of intracranial contents. As the skull grows, the midline cranium bifidum occultum defect is separated into bilateral enlarged parietal foramina (EPF) by a midline osseous bridge.
http://purl.obolibrary.org/obo/HP_0004425	Flat forehead	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		A forehead with abnormal flatness.
http://purl.obolibrary.org/obo/HP_0004428	Elfin facies	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		This is a description previously used to describe a facial form characterized by a short, upturned nose, wide mouth, widely spaced eyes, and full cheeks. Because of the imprecision in this definition it is preferable to describe these features precisely. This term is retained because it was often used in the past, but it should not be used for new annotations.
http://purl.obolibrary.org/obo/HP_0004432	Agammaglobulinemia	http://purl.obolibrary.org/obo/HP_0004313	Decreased circulating immunoglobulin concentration		A lasting absence of total IgG and total IgA and total IgM in the blood circulation, whereby at most trace quantities can be measured.
http://purl.obolibrary.org/obo/HP_0004433	Decreased secretory IgA concentration	http://purl.obolibrary.org/obo/HP_0041078	Decreased immunoglobulin level in body fluid		Deficiency of secretory IgA (polymers of 2-4 IgA monomers are linked by two additional chains) and is the primary antibody response at the mucosal level, where it forms immune complexes with pathogens and allergens.
http://purl.obolibrary.org/obo/HP_0004434	Decreased circulating complement C8 concentration	http://purl.obolibrary.org/obo/HP_0033057	Decreased circulating terminal complement component concentration		Concentration of the complement component C8 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0004437	Cranial hyperostosis	http://purl.obolibrary.org/obo/HP_0100774	Hyperostosis		Excessive growth of the bones of cranium, i.e., of the skull.
http://purl.obolibrary.org/obo/HP_0004438	Hyperostosis frontalis interna	http://purl.obolibrary.org/obo/HP_0004437	Cranial hyperostosis		Bony overgrowth of the internal (endosteal) surface of the frontal bone.
http://purl.obolibrary.org/obo/HP_0004439	Craniofacial dysostosis	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		A characteristic appearance resulting from defective ossification of craniofacial bones.
http://purl.obolibrary.org/obo/HP_0004440	Coronal craniosynostosis	http://purl.obolibrary.org/obo/HP_0001363	Craniosynostosis		Premature closure of the coronal suture of skull.
http://purl.obolibrary.org/obo/HP_0004442	Sagittal craniosynostosis	http://purl.obolibrary.org/obo/HP_0001363	Craniosynostosis		A kind of craniosynostosis affecting the sagittal suture.
http://purl.obolibrary.org/obo/HP_0004443	Lambdoidal craniosynostosis	http://purl.obolibrary.org/obo/HP_0001363	Craniosynostosis		A kind of craniosynostosis affecting the lambdoidal suture.
http://purl.obolibrary.org/obo/HP_0004444	Spherocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		The presence of erythrocytes that are sphere-shaped.
http://purl.obolibrary.org/obo/HP_0004445	Elliptocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		The presence of elliptical, cigar-shaped erythrocytes on peripheral blood smear.
http://purl.obolibrary.org/obo/HP_0004446	Stomatocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		The presence of erythrocytes with a mouth-shaped (stoma) area of central pallor on peripheral blood smear.
http://purl.obolibrary.org/obo/HP_0004448	Fulminant hepatic failure	http://purl.obolibrary.org/obo/HP_0006554	Acute hepatic failure		Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as fulminant if there is onset of encephalopathy within 4 weeks of the onset of symptoms in a patient with a previously healthy liver.
http://purl.obolibrary.org/obo/HP_0004450	Preauricular skin furrow	http://purl.obolibrary.org/obo/HP_0000383	Abnormal periauricular region morphology		A groove of the skin immediately in front of the ear.
http://purl.obolibrary.org/obo/HP_0004451	Postauricular skin tag	http://purl.obolibrary.org/obo/HP_0000383	Abnormal periauricular region morphology		A rudimentary tag of ear tissue often containing a core of cartilage and located just in back of the auricle (outer part of the ear).
http://purl.obolibrary.org/obo/HP_0004452	Abnormality of the middle ear ossicles	http://purl.obolibrary.org/obo/HP_0008609	Abnormal middle ear morphology		An abnormality of the middle-ear ossicles (three small bones called malleus, incus, and stapes) that are contained within the middle ear and serve to transmit sounds from the air to the fluid-filled labyrinth (cochlea).
http://purl.obolibrary.org/obo/HP_0004453	Overfolding of the superior helices	http://purl.obolibrary.org/obo/HP_0000396	Overfolded helix		A condition in which the superior portion of the helix is folded over to a greater degree than normal.
http://purl.obolibrary.org/obo/HP_0004458	Dilatated internal auditory canal	http://purl.obolibrary.org/obo/HP_0011384	Abnormality of the internal auditory canal		The presence of a dilated inner part of external acoustic meatus.
http://purl.obolibrary.org/obo/HP_0004459	Exostosis of the external auditory canal	http://purl.obolibrary.org/obo/HP_0040095	Neoplasm of the outer ear		A benign bony growth projecting outward from a bone surface within the external auditory canal.
http://purl.obolibrary.org/obo/HP_0004461	Congenital earlobe sinuses	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Pits in the earlobes at the location where ears are typically pierced for earrings.
http://purl.obolibrary.org/obo/HP_0004463	Absent brainstem auditory responses	http://purl.obolibrary.org/obo/HP_0006958	Abnormal auditory evoked potentials		Lack of measurable response to stimulation of auditory evoked potentials.
http://purl.obolibrary.org/obo/HP_0004464	Postauricular pit	http://purl.obolibrary.org/obo/HP_0100277	Periauricular skin pits		Benign congenital lesion of the postauricular soft tissue consisting of a blind-ending narrow tube or pit.
http://purl.obolibrary.org/obo/HP_0004466	Delayed brainstem auditory evoked response conduction time	http://purl.obolibrary.org/obo/HP_0006958	Abnormal auditory evoked potentials		An abnormal increase (delay) in the conduction time of the brainstem auditory-evoked response.
http://purl.obolibrary.org/obo/HP_0004467	Preauricular pit	http://purl.obolibrary.org/obo/HP_0100277	Periauricular skin pits		Small indentation anterior to the insertion of the ear.
http://purl.obolibrary.org/obo/HP_0004468	Anomalous tracheal cartilage	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		An abnormality of the C-shaped rings of hyaline cartilage, normally 16 to 20 in number, that occupy the anterior two-thirds of the circumference of the trachea (the posterior portion of the ring is completed by fibrous and smooth muscle tissue).
http://purl.obolibrary.org/obo/HP_0004469	Chronic bronchitis	http://purl.obolibrary.org/obo/HP_0012387	Bronchitis		Chronic inflammation of the bronchi.
http://purl.obolibrary.org/obo/HP_0004470	Atretic occipital cephalocele	http://purl.obolibrary.org/obo/HP_0011815	Cephalocele		A congenital defect in the occipital region of the skull, covered by skin of the scalp and containing meninges or remnants of glial or neural tissues.
http://purl.obolibrary.org/obo/HP_0004471	Aplasia cutis congenita over the scalp vertex	http://purl.obolibrary.org/obo/HP_0007385	Aplasia cutis congenita of scalp		A developmental defect resulting in the congenital absence of skin on the scalp vertex, often just lateral to the midline.
http://purl.obolibrary.org/obo/HP_0004472	Mandibular hyperostosis	http://purl.obolibrary.org/obo/HP_0005465	Facial hyperostosis		Hyperostosis (bony overgrowth) of the mandible.
http://purl.obolibrary.org/obo/HP_0004474	Persistent open anterior fontanelle	http://purl.obolibrary.org/obo/HP_0001476	Delayed closure of the anterior fontanelle		The anterior fontanelle generally ossifies by around the 18th month of life. A persistent open anterior fontanelle is diagnosed if closure is delayed beyond this age.
http://purl.obolibrary.org/obo/HP_0004476	Aplasia cutis congenita over parietal area	http://purl.obolibrary.org/obo/HP_0007385	Aplasia cutis congenita of scalp		A developmental defect resulting in the congenital absence of skin on the scalp in the parietal area.
http://purl.obolibrary.org/obo/HP_0004481	Progressive macrocephaly	http://purl.obolibrary.org/obo/HP_0000256	Macrocephaly		The progressive development of an abnormally large skull.
http://purl.obolibrary.org/obo/HP_0004482	Relative macrocephaly	http://purl.obolibrary.org/obo/HP_0000256	Macrocephaly		A relatively mild degree of macrocephaly in which the head circumference is not above two standard deviations from the mean, but appears dysproportionately large when other factors such as body stature are taken into account.
http://purl.obolibrary.org/obo/HP_0004484	Craniofacial asymmetry	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		Asymmetry of the bones of the skull and the face.
http://purl.obolibrary.org/obo/HP_0004485	Cessation of head growth	http://purl.obolibrary.org/obo/HP_0005484	Secondary microcephaly		Stagnation of head growth seen as flattening of the head circumference curve.
http://purl.obolibrary.org/obo/HP_0004487	Acrobrachycephaly	http://purl.obolibrary.org/obo/HP_0000248	Brachycephaly		An abnormality of head shape characterized by the presence of a short, wide head as well as a pointy or conical form of the top of the head owing to premature closure of the coronal and lambdoid sutures.
http://purl.obolibrary.org/obo/HP_0004488	Macrocephaly at birth	http://purl.obolibrary.org/obo/HP_0000256	Macrocephaly		The presence of an abnormally large skull with onset at birth.
http://purl.obolibrary.org/obo/HP_0004490	Calvarial hyperostosis	http://purl.obolibrary.org/obo/HP_0004437	Cranial hyperostosis		Excessive growth of the calvaria.
http://purl.obolibrary.org/obo/HP_0004491	Large posterior fontanelle	http://purl.obolibrary.org/obo/HP_0000239	Large fontanelles		An enlargement of the posterior fontanelle relative to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0004492	Widely patent fontanelles and sutures	http://purl.obolibrary.org/obo/HP_0010537	Wide cranial sutures		An abnormally increased width of the cranial fontanelles and sutures.
http://purl.obolibrary.org/obo/HP_0004493	Craniofacial hyperostosis	http://purl.obolibrary.org/obo/HP_0004437	Cranial hyperostosis		Excessive growth of the craniofacial bones.
http://purl.obolibrary.org/obo/HP_0004502	Bilateral choanal atresia	http://purl.obolibrary.org/obo/HP_0000453	Choanal atresia		Bilateral absence (atresia) of the posterior nasal aperture (choana).
http://purl.obolibrary.org/obo/HP_0004510	Pancreatic islet-cell hyperplasia	http://purl.obolibrary.org/obo/HP_0006476	Abnormality of the pancreatic islet cells		Hyperplasia of the islets of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells.
http://purl.obolibrary.org/obo/HP_0004523	Long eyebrows	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		Increased length of the hairs of the eyebrows.
http://purl.obolibrary.org/obo/HP_0004524	Temporal hypotrichosis	http://purl.obolibrary.org/obo/HP_0011361	Congenital abnormal hair pattern		Reduced or lacking hair growth in the temporal region (i.e., around the temples on the side of the skull).
http://purl.obolibrary.org/obo/HP_0004528	Generalized hypotrichosis	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Reduced or lacking hair growth in a generalized distribution.
http://purl.obolibrary.org/obo/HP_0004532	Sacral hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		Excessive, increased hair growth located in the sacral region.
http://purl.obolibrary.org/obo/HP_0004535	Anterior cervical hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		Anterior cervical hypertrichosis (ACH) or 'hairy throat' refers to the presence of a tuft of terminal hair on the anterior neck, just above the laryngeal prominence.
http://purl.obolibrary.org/obo/HP_0004540	Congenital, generalized hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		A confluent, generalized overgrowth of silvery blonde to gray lanugo hair at birth.
http://purl.obolibrary.org/obo/HP_0004554	Generalized hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		Generalized excessive, abnormal hairiness.
http://purl.obolibrary.org/obo/HP_0004558	Cervical platyspondyly	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		A flattened vertebral body shape with reduced distance between the vertebral endplates affecting the cervical spine.
http://purl.obolibrary.org/obo/HP_0004563	Increased spinal bone density	http://purl.obolibrary.org/obo/HP_0004330	Increased skull ossification		Increased bone density affecting the bones of the spine (vertebral column).
http://purl.obolibrary.org/obo/HP_0004568	Beaking of vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Anterior tongue-like protrusions of the vertebral bodies.
http://purl.obolibrary.org/obo/HP_0004570	Increased vertebral height	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Increased top to bottom height of vertebral bodies.
http://purl.obolibrary.org/obo/HP_0004573	Anterior wedging of T11	http://purl.obolibrary.org/obo/HP_0008422	Vertebral wedging		An abnormality of the shape of the thoracic vertebra T11 such that it is wedge-shaped (narrow towards the front).
http://purl.obolibrary.org/obo/HP_0004576	Sclerotic vertebral endplates	http://purl.obolibrary.org/obo/HP_0005106	Abnormality of the vertebral endplates		Sclerosis (increased density) affecting vertebral end plates.
http://purl.obolibrary.org/obo/HP_0004580	Anterior scalloping of vertebral bodies	http://purl.obolibrary.org/obo/HP_0004586	Biconcave vertebral bodies		An excessive concavity of the anterior surface of one or more vertebral bodies.
http://purl.obolibrary.org/obo/HP_0004590	Hypoplastic sacrum	http://purl.obolibrary.org/obo/HP_0008517	Aplasia/Hypoplasia of the sacrum		A developmental defect characterized by undergrowth of the sacrum, which is a large, triangular bone at the base of the spine that forms by the fusing of the sacral vertebrae (S1-S5).
http://purl.obolibrary.org/obo/HP_0004592	Thoracic platyspondyly	http://purl.obolibrary.org/obo/HP_0000926	Platyspondyly		A flattened vertebral body shape with reduced distance between the vertebral endplates affecting the thoracic spine.
http://purl.obolibrary.org/obo/HP_0004598	Supernumerary vertebral ossification centers	http://purl.obolibrary.org/obo/HP_0100569	Abnormally ossified vertebrae		Three ossification sites are present in typical vertebral bodies (C3-L5): a single ossification center in the vertebral body, and one each in the two neural arches. This term applies if there are additional vertebral ossification centers present during the development and maturation of the spine.
http://purl.obolibrary.org/obo/HP_0004601	Spina bifida occulta at L5	http://purl.obolibrary.org/obo/HP_0003298	Spina bifida occulta		The closed form of spina bifida with incomplete closure of the vertebra L5 with intact overlying skin.
http://purl.obolibrary.org/obo/HP_0004602	Cervical C2/C3 vertebral fusion	http://purl.obolibrary.org/obo/HP_0002949	Fused cervical vertebrae		Fusion of cervical vertebrae at C2 and C3, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development, leading to a short neck with a low hairline at the back of the head, and restricted mobility of the upper spine.
http://purl.obolibrary.org/obo/HP_0004605	Absent vertebral body mineralization	http://purl.obolibrary.org/obo/HP_0004599	Absent or minimally ossified vertebral bodies		A lack of bone mineralization of the vertebral bodies.
http://purl.obolibrary.org/obo/HP_0004606	Unossified vertebral bodies	http://purl.obolibrary.org/obo/HP_0004599	Absent or minimally ossified vertebral bodies		A lack of ossification of the vertebral bodies.
http://purl.obolibrary.org/obo/HP_0004607	Anterior beaking of lower thoracic vertebrae	http://purl.obolibrary.org/obo/HP_0004568	Beaking of vertebral bodies		Anterior tongue-like protrusions of the lower thoracic vertebral bodies.
http://purl.obolibrary.org/obo/HP_0004608	Anteriorly placed odontoid process	http://purl.obolibrary.org/obo/HP_0003310	Abnormal odontoid process morphology		Anterior mislocalization of the dens of the axis.
http://purl.obolibrary.org/obo/HP_0004610	Lumbar spinal canal stenosis	http://purl.obolibrary.org/obo/HP_0003416	Spinal canal stenosis		An abnormal narrowing of the lumbar spinal canal.
http://purl.obolibrary.org/obo/HP_0004614	Spina bifida occulta at S1	http://purl.obolibrary.org/obo/HP_0003298	Spina bifida occulta		The closed form of spina bifida with incomplete closure of S1 with intact overlying skin.
http://purl.obolibrary.org/obo/HP_0004616	Cleft vertebral arch	http://purl.obolibrary.org/obo/HP_0008438	Vertebral arch anomaly		A discontinuity of the vertebral arch, i.e., of the posterior part of a vertebra.
http://purl.obolibrary.org/obo/HP_0004617	Butterfly vertebral arch	http://purl.obolibrary.org/obo/HP_0008438	Vertebral arch anomaly		Butterfly vertebrae have a cleft through the body of the vertebrae and a funnel shape at the ends.
http://purl.obolibrary.org/obo/HP_0004621	Enlarged vertebral pedicles	http://purl.obolibrary.org/obo/HP_0030277	Abnormal vertebral pedicle morphology		Increased size of the vertebral pedicle.
http://purl.obolibrary.org/obo/HP_0004622	Progressive intervertebral space narrowing	http://purl.obolibrary.org/obo/HP_0002945	Intervertebral space narrowing		A progressive form of decreased height of the intervertebral disk.
http://purl.obolibrary.org/obo/HP_0004625	Biconvex vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		Presence of abnormal convexity of the upper and lower end plates of the vertebrae, i.e., an exaggerated bulging out of the upper and lower vertebral end plates.
http://purl.obolibrary.org/obo/HP_0004629	Small cervical vertebral bodies	http://purl.obolibrary.org/obo/HP_0008479	Hypoplastic vertebral bodies		Reduced size of cervical vertebrae.
http://purl.obolibrary.org/obo/HP_0004630	Anterior beaking of thoracic vertebrae	http://purl.obolibrary.org/obo/HP_0004568	Beaking of vertebral bodies		Anterior tongue-like protrusions of thoracic vertebral bodies.
http://purl.obolibrary.org/obo/HP_0004632	Cervical segmentation defect	http://purl.obolibrary.org/obo/HP_0003422	Vertebral segmentation defect		An abnormality related to a defect of vertebral separation of cervical vertebrae during development.
http://purl.obolibrary.org/obo/HP_0004633	Lower thoracic kyphosis	http://purl.obolibrary.org/obo/HP_0002942	Thoracic kyphosis		Over curvature of the lower thoracic region, leading to a round back or if sever to a hump.
http://purl.obolibrary.org/obo/HP_0004635	Cervical C5/C6 vertebrae fusion	http://purl.obolibrary.org/obo/HP_0002949	Fused cervical vertebrae		Fusion of the C5 and C6 cervical vertebrae.
http://purl.obolibrary.org/obo/HP_0004639	Elevated amniotic fluid alpha-fetoprotein concentration	http://purl.obolibrary.org/obo/HP_0034899	Abnormal amniotic fluid protein concentration		An elevation of alpha-feto protein measured in the amniotic fluid.
http://purl.obolibrary.org/obo/HP_0004646	Hypoplasia of the nasal bone	http://purl.obolibrary.org/obo/HP_0010940	Aplasia/Hypoplasia of the nasal bone		Underdevelopment of the nasal bone.
http://purl.obolibrary.org/obo/HP_0004660	Hypoplasia of facial musculature	http://purl.obolibrary.org/obo/HP_0000301	Abnormality of facial musculature		Underdevelopment of one or more muscles innervated by the facial nerve (the seventh cranial nerve).
http://purl.obolibrary.org/obo/HP_0004661	Frontalis muscle weakness	http://purl.obolibrary.org/obo/HP_3000004	Abnormal frontalis muscle physiology		Reduced strength of the frontalis muscle (which is located on the forehead).
http://purl.obolibrary.org/obo/HP_0004664	Facial midline hemangioma	http://purl.obolibrary.org/obo/HP_0000329	Facial hemangioma		Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the midline region of the face.
http://purl.obolibrary.org/obo/HP_0004681	Deep longitudinal plantar crease	http://purl.obolibrary.org/obo/HP_0001869	Deep plantar creases		Narrow, paramedian longitudinal depressions in the plantar skin of the forefoot.
http://purl.obolibrary.org/obo/HP_0004684	Talipes valgus	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Outward turning of the heel, resulting in clubfoot with the person walking on the inner part of the foot.
http://purl.obolibrary.org/obo/HP_0004686	Short third metatarsal	http://purl.obolibrary.org/obo/HP_0010743	Short metatarsal		Underdevelopment of the Third metatarsal bone leading to a short (hypoplastic) third metatarsal bone.
http://purl.obolibrary.org/obo/HP_0004689	Short fourth metatarsal	http://purl.obolibrary.org/obo/HP_0040035	Abnormality of the fourth metatarsal bone		Short fourth metatarsal bone.
http://purl.obolibrary.org/obo/HP_0004690	Thickened Achilles tendon	http://purl.obolibrary.org/obo/HP_0032523	Tendon thickening		An abnormal thickening of the Achilles tendon.
http://purl.obolibrary.org/obo/HP_0004691	2-3 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes two and three.
http://purl.obolibrary.org/obo/HP_0004692	4-5 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes four and five.
http://purl.obolibrary.org/obo/HP_0004695	Calcaneal epiphyseal stippling	http://purl.obolibrary.org/obo/HP_0010655	Epiphyseal stippling		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the calcaneus.
http://purl.obolibrary.org/obo/HP_0004699	Osteoporotic metatarsal	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		Decrease in mass and density of the metatarsal bones.
http://purl.obolibrary.org/obo/HP_0004704	Short fifth metatarsal	http://purl.obolibrary.org/obo/HP_0010743	Short metatarsal		Short (hypoplastic) fifth metatarsal bone.
http://purl.obolibrary.org/obo/HP_0004712	Renal malrotation	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An abnormality of the normal developmental rotation of the kidney leading to an abnormal orientation of the kidney.
http://purl.obolibrary.org/obo/HP_0004713	Reversible renal failure	http://purl.obolibrary.org/obo/HP_0000083	Renal insufficiency		Acute renal failure with resolution of manifestations.
http://purl.obolibrary.org/obo/HP_0004717	Axial malrotation of the kidney	http://purl.obolibrary.org/obo/HP_0004712	Renal malrotation		An abnormality of the normal developmental rotation of the kidney leading to an abnormal axial orientation of the kidney.
http://purl.obolibrary.org/obo/HP_0004719	Hyperechogenic kidneys	http://purl.obolibrary.org/obo/HP_0033130	Abnormal renal echogenicity		An increase in amplitude of waves returned in ultrasonography of the kidney, which is generally displayed as increased brightness of the signal.
http://purl.obolibrary.org/obo/HP_0004722	Thickened glomerular basement membrane	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Prominent glomerular basement membrane (GBM), reflecting an increase in thickness (subjective estimate) of the basal lamina of the glomerulus of the kidney.
http://purl.obolibrary.org/obo/HP_0004724	Calcium nephrolithiasis	http://purl.obolibrary.org/obo/HP_0000787	Kidney stone		The presence of calcium-containing calculi (stones) in the kidneys.
http://purl.obolibrary.org/obo/HP_0004727	Impaired renal concentrating ability	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		A defect in the ability to concentrate the urine.
http://purl.obolibrary.org/obo/HP_0004729	Acute tubulointerstitial nephritis	http://purl.obolibrary.org/obo/HP_0001970	Tubulointerstitial nephritis		Acute inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.
http://purl.obolibrary.org/obo/HP_0004732	Impaired renal uric acid clearance	http://purl.obolibrary.org/obo/HP_0011036	Abnormality of renal excretion		A reduction in the ability of the kidneys to remove uric acid from the serum.
http://purl.obolibrary.org/obo/HP_0004734	Renal cortical microcysts	http://purl.obolibrary.org/obo/HP_0000803	Renal cortical cysts		Cysts of microscopic size confined to the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0004736	Crossed fused renal ectopia	http://purl.obolibrary.org/obo/HP_0000086	Ectopic kidney		A developmental anomaly in which the kidneys are fused and localized on the same side of the midline. This anomaly is thought to result from disruption of the normal embryologic migration of the kidneys.
http://purl.obolibrary.org/obo/HP_0004737	Global glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0000096	Glomerular sclerosis		Obliteration of the glomerular capillary lumen by increased collagenous matrix, with or without hyalinosis or foam cells. Sclerosis involves 100% of the glomerular tuft. Relative to other patent glomeruli in the sample, glomerular size is preserved, or increased/decreased by no more than 50%.
http://purl.obolibrary.org/obo/HP_0004743	Chronic tubulointerstitial nephritis	http://purl.obolibrary.org/obo/HP_0001970	Tubulointerstitial nephritis		Chronic inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.
http://purl.obolibrary.org/obo/HP_0004746	Glomerular subendothelial electron-dense deposits	http://purl.obolibrary.org/obo/HP_0030949	Glomerular deposits		Electron dense deposits at the glomerular basement membrane,
http://purl.obolibrary.org/obo/HP_0004749	Atrial flutter	http://purl.obolibrary.org/obo/HP_0001692	Atrial arrhythmia		A type of atrial arrhythmia characterized by atrial rates of between 240 and 400 beats per minute and some degree of atrioventricular node conduction block. Typically, the ventricular rate is half the atrial rate. In the EKG; atrial flutter waves are observed as sawtooth-like atrial activity. Pathophysiologically, atrial flutter is a form of atrial reentry in which there is a premature electrical impulse creates a self-propagating circuit.
http://purl.obolibrary.org/obo/HP_0004751	Paroxysmal ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004756	Ventricular tachycardia		Episodes of ventricular tachycardia that have a sudden onset and ending.
http://purl.obolibrary.org/obo/HP_0004752	Congenital atrioventricular dissociation	http://purl.obolibrary.org/obo/HP_0011709	Atrioventricular dissociation		A form of atrioventricular (AV) dissociation (i.e., the atria and the ventricles are under the control of two separate pacemakers) with congenital onset.
http://purl.obolibrary.org/obo/HP_0004754	Permanent atrial fibrillation	http://purl.obolibrary.org/obo/HP_0005110	Atrial fibrillation		Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent.
http://purl.obolibrary.org/obo/HP_0004756	Ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0001649	Tachycardia		A tachycardia originating in the ventricles characterized by rapid heart rate (over 100 beats per minute) and broad QRS complexes (over 120 ms).
http://purl.obolibrary.org/obo/HP_0004757	Paroxysmal atrial fibrillation	http://purl.obolibrary.org/obo/HP_0005110	Atrial fibrillation		Episodes of atrial fibrillation that typically last for several hours up to one day and terminate spontaneously.
http://purl.obolibrary.org/obo/HP_0004758	Effort-induced polymorphic ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004756	Ventricular tachycardia		Polymorphic ventricular arrhythmias of varying morphologythat do not exist under resting conditions but appear only upon physical exercise or catecholamine administration.
http://purl.obolibrary.org/obo/HP_0004762	Hypoplasia of right ventricle	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		Underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells.
http://purl.obolibrary.org/obo/HP_0004763	Paroxysmal supraventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004755	Supraventricular tachycardia		An episodic form of supraventricular tachycardia with abrupt onset and termination.
http://purl.obolibrary.org/obo/HP_0004764	Myxomatous mitral valve degeneration	http://purl.obolibrary.org/obo/HP_0001634	Mitral valve prolapse		Myxomatous mitral valve is defined as the presence of excess leaflet tissue and leaflet thickening greater than 5 mm, resulting in a prolapse greater than 2 mm into the left atrium on parasternal long axis view.
http://purl.obolibrary.org/obo/HP_0004768	Sparse anterior scalp hair	http://purl.obolibrary.org/obo/HP_0002209	Sparse scalp hair		Decreased number of head hairs per unit area on the anterior region of the scalp.
http://purl.obolibrary.org/obo/HP_0004779	Brittle scalp hair	http://purl.obolibrary.org/obo/HP_0002299	Brittle hair		Fragile, easily breakable scalp hair.
http://purl.obolibrary.org/obo/HP_0004780	Elbow hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		Excessive, increased hair growth located in the elbow region.
http://purl.obolibrary.org/obo/HP_0004783	Duodenal polyposis	http://purl.obolibrary.org/obo/HP_0030256	Small intestinal polyposis		Presence of multiple polyps in the duodenum.
http://purl.obolibrary.org/obo/HP_0004784	Juvenile gastrointestinal polyposis	http://purl.obolibrary.org/obo/HP_0004390	Hamartomatous polyposis		The presence of multiple juvenile polyps in the stomach and intestine. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands. Juvenile polyps are a specific type of hamartomatous polyps.
http://purl.obolibrary.org/obo/HP_0004785	Malrotation of colon	http://purl.obolibrary.org/obo/HP_0002566	Intestinal malrotation		An anatomical anomaly that results from an abnormal rotation of the gut as it returns to the abdominal cavity during embryogenesis.
http://purl.obolibrary.org/obo/HP_0004787	Fulminant hepatitis	http://purl.obolibrary.org/obo/HP_0012115	Hepatitis		Acute hepatitis complicated by acute liver failure with hepatic encephalopathy occurring less than 8 weeks after the onset of jaundice.
http://purl.obolibrary.org/obo/HP_0004788	Intestinal lymphedema	http://purl.obolibrary.org/obo/HP_0005225	Intestinal edema		Fluid retention and edema in the intestine caused by a compromised lymphatic system.
http://purl.obolibrary.org/obo/HP_0004790	Hypoplasia of the small intestine	http://purl.obolibrary.org/obo/HP_0005245	Intestinal hypoplasia		Underdevelopment of the small intestine.
http://purl.obolibrary.org/obo/HP_0004791	Esophageal ulceration	http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer		Defect in the epithelium of the esophagus, essentially an open sore in the lining of the esophagus.
http://purl.obolibrary.org/obo/HP_0004792	Rectoperineal fistula	http://purl.obolibrary.org/obo/HP_0004871	Perineal fistula		The presence of a fistula between the perineum and the rectum.
http://purl.obolibrary.org/obo/HP_0004794	Malrotation of small bowel	http://purl.obolibrary.org/obo/HP_0002566	Intestinal malrotation		A deviation from the normal rotation of the midgut during embryologic development with mislocalization of the small bowel.
http://purl.obolibrary.org/obo/HP_0004795	Hamartomatous stomach polyps	http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach		Polyp-like protrusions which are histologically hamartomas located in the stomach.
http://purl.obolibrary.org/obo/HP_0004797	Multiple small bowel atresias	http://purl.obolibrary.org/obo/HP_0011100	Intestinal atresia		The presence of multiple areas of atresia affecting the small intestine.
http://purl.obolibrary.org/obo/HP_0004798	Recurrent infection of the gastrointestinal tract	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		Recurrent infection of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0004802	Episodic hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		A form of hemolytic anemia that occurs in repeated episodes.
http://purl.obolibrary.org/obo/HP_0004804	Congenital hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		A form of hemolytic anemia with congenital onset.
http://purl.obolibrary.org/obo/HP_0004808	Acute myeloid leukemia	http://purl.obolibrary.org/obo/HP_0002488	Acute leukemia		A form of leukemia characterized by overproduction of an early myeloid cell.
http://purl.obolibrary.org/obo/HP_0004809	Neonatal alloimmune thrombocytopenia	http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia		Low platelet count associated with maternal platelet-specific alloantibodies.
http://purl.obolibrary.org/obo/HP_0004810	Congenital hypoplastic anemia	http://purl.obolibrary.org/obo/HP_0001908	Hypoplastic anemia		A type of hypoplastic anemia with congenital onset.
http://purl.obolibrary.org/obo/HP_0004812	B Acute Lymphoblastic Leukemia	http://purl.obolibrary.org/obo/HP_0006721	Acute lymphoblastic leukemia		A type of ALL characterized by elevated levels of B-cell lymphoblasts in the bone marrow and the blood.
http://purl.obolibrary.org/obo/HP_0004813	Post-transfusion thrombocytopenia	http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia		Sudden onset of thrombocytopenia (reduced platelet count) within 5-10 days of the transfusion of blood products. The clinical presentation is post-transfusion purpura (PTP), wigth severe thrmbocytopenia, epistaxis, and hemorrhages.
http://purl.obolibrary.org/obo/HP_0004814	Fava bean-induced hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		A kind of hemolytic anemia that is induced by the ingestion of fava beans.
http://purl.obolibrary.org/obo/HP_0004817	Drug-sensitive hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		A form of hemolytic anemia that is triggered by ingestion of certain drugs.
http://purl.obolibrary.org/obo/HP_0004819	Normocytic hypoplastic anemia	http://purl.obolibrary.org/obo/HP_0001908	Hypoplastic anemia		A type of hypoplastic anemia in which the erythrocytes have a normal cell volume (the mean corpuscular volume is within normal limits).
http://purl.obolibrary.org/obo/HP_0004820	Acute myelomonocytic leukemia	http://purl.obolibrary.org/obo/HP_0012324	Myeloid leukemia		An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors.
http://purl.obolibrary.org/obo/HP_0004821	Hypersegmentation of neutrophil nuclei	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		An excessive division of the lobes of the nucleus of a neutrophil.
http://purl.obolibrary.org/obo/HP_0004823	Anisopoikilocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		A type of poikilocytosis characterized by the presence in the blood of erythrocytes of varying sizes and abnormal shapes.
http://purl.obolibrary.org/obo/HP_0004825	Increased hemoglobin oxygen affinity	http://purl.obolibrary.org/obo/HP_0020054	Abnormal erythrocyte physiology		An abnormal increase in the binding affinity of hemoglobin for oxygen.
http://purl.obolibrary.org/obo/HP_0004826	Folate-unresponsive megaloblastic anemia	http://purl.obolibrary.org/obo/HP_0001889	Megaloblastic anemia		A type of megaloblastic anemia that does not improve upon administration of folate. Since vitamin B12 acts by promoting recycling of folate, administration of vitamin B12 also does not improve this type of anemia.
http://purl.obolibrary.org/obo/HP_0004828	Refractory anemia with ringed sideroblasts	http://purl.obolibrary.org/obo/HP_0012150	Single lineage myelodysplasia		A type of myelodysplastic syndrome characterized by less than 5% myeloblasts in the bone marrow, but with 15% or greater red cell precursors in the marrow being abnormal iron-stuffed cells called ringed sideroblasts.
http://purl.obolibrary.org/obo/HP_0004831	Recurrent thromboembolism	http://purl.obolibrary.org/obo/HP_0001907	Thromboembolism		Repeated episodes of obstruction of blood flow due to an embolus, i.e., blood clot that has traveled from its point of origin within the blood stream.
http://purl.obolibrary.org/obo/HP_0004835	Microspherocytosis	http://purl.obolibrary.org/obo/HP_0004444	Spherocytosis		The presence of erythrocytes that are sphere-shaped and reduced in size.
http://purl.obolibrary.org/obo/HP_0004836	Acute promyelocytic leukemia	http://purl.obolibrary.org/obo/HP_0002488	Acute leukemia		A type of acute myeloid leukemia in which abnormal promyelocytes predominate.
http://purl.obolibrary.org/obo/HP_0004839	Pyropoikilocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		A form of severe hemolytic anemia characterized by erythrocyte morphology reminiscent of that seen in patients after a thermal burn.
http://purl.obolibrary.org/obo/HP_0004840	Hypochromic microcytic anemia	http://purl.obolibrary.org/obo/HP_0001935	Microcytic anemia		A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes.
http://purl.obolibrary.org/obo/HP_0004841	Reduced factor XII activity	http://purl.obolibrary.org/obo/HP_0010989	Abnormality of the intrinsic pathway		Decreased activity of coagulation factor XII. Factor XII (fXII) is part of the intrinsic coagulation pathway and binds to exposed collagen at site of vessel wall injury, activated by high-MW kininogen and kallikrein, thereby initiating the coagulation cascade.
http://purl.obolibrary.org/obo/HP_0004844	Coombs-positive hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		A type of hemolytic anemia in which the Coombs test is positive.
http://purl.obolibrary.org/obo/HP_0004845	Acute monocytic leukemia	http://purl.obolibrary.org/obo/HP_0002488	Acute leukemia		The accumulation of transformed primitive hematopoietic blast cells, which lose their ability of normal differentiation and proliferation.
http://purl.obolibrary.org/obo/HP_0004846	Prolonged bleeding after surgery	http://purl.obolibrary.org/obo/HP_0011890	Prolonged bleeding following procedure		Bleeding that persists longer than the normal time following a surgical procedure.
http://purl.obolibrary.org/obo/HP_0004848	Ph-positive acute lymphoblastic leukemia	http://purl.obolibrary.org/obo/HP_0006721	Acute lymphoblastic leukemia		A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity.
http://purl.obolibrary.org/obo/HP_0004850	Recurrent deep vein thrombosis	http://purl.obolibrary.org/obo/HP_0002625	Deep venous thrombosis		Repeated episodes of the formation of a blot clot in a deep vein.
http://purl.obolibrary.org/obo/HP_0004851	Folate-responsive megaloblastic anemia	http://purl.obolibrary.org/obo/HP_0001889	Megaloblastic anemia		A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of folate.
http://purl.obolibrary.org/obo/HP_0004852	Reduced leukocyte alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity		Decreased alkaline phosphatase measured within leukocytes.
http://purl.obolibrary.org/obo/HP_0004854	Intermittent thrombocytopenia	http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia		Reduced platelet count that occurs sporadically, i.e., it comes and goes.
http://purl.obolibrary.org/obo/HP_0004855	Reduced protein S activity	http://purl.obolibrary.org/obo/HP_0030780	Abnormality of the protein C anticoagulant pathway		An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein S. Protein S is a cofactor of protein C.
http://purl.obolibrary.org/obo/HP_0004856	Normochromic microcytic anemia	http://purl.obolibrary.org/obo/HP_0001935	Microcytic anemia		A type of anemia characterized by an normal concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes.
http://purl.obolibrary.org/obo/HP_0004857	Hyperchromic macrocytic anemia	http://purl.obolibrary.org/obo/HP_0001972	Macrocytic anemia		A type of anemia characterized by abnormally large erythrocytes with abnormally high amounts of hemoglobin.
http://purl.obolibrary.org/obo/HP_0004859	Amegakaryocytic thrombocytopenia	http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia		Thrombocytopenia related to lack of or severe reduction in the count of megakaryocytes.
http://purl.obolibrary.org/obo/HP_0004860	Thiamine-responsive megaloblastic anemia	http://purl.obolibrary.org/obo/HP_0001889	Megaloblastic anemia		A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of thiamine.
http://purl.obolibrary.org/obo/HP_0004864	Elevated bone marrow ring sideroblast count	http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology		Count of ring sideroblasts in the bone marrow above the upper limit of normal. Ring sideroblasts are nucleated erythroblasts with a pathologic accumulation of iron granules in the mitochondrial matrix. They can be detected by Prussian blue staining as blue perinuclear aggregates in bone marrow aspirate erythroblasts.
http://purl.obolibrary.org/obo/HP_0004866	Impaired ADP-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal platelet response to ADP as manifested by reduced or lacking aggregation of platelets upon addition of ADP.
http://purl.obolibrary.org/obo/HP_0004870	Chronic hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		An chronic form of hemolytic anemia.
http://purl.obolibrary.org/obo/HP_0004871	Perineal fistula	http://purl.obolibrary.org/obo/HP_0100589	Urogenital fistula		The presence of a fistula between the bowel and the perineum.
http://purl.obolibrary.org/obo/HP_0004872	Incisional hernia	http://purl.obolibrary.org/obo/HP_0004299	Hernia of the abdominal wall		An abdominal hernia that occurs at a site of weakness in the abdominal wall resulting from an incompletely-healed surgical wound.
http://purl.obolibrary.org/obo/HP_0004876	Spontaneous neonatal pneumothorax	http://purl.obolibrary.org/obo/HP_0002108	Spontaneous pneumothorax		Pneumothorax occurring neonatally without traumatic injury to the chest or lung.
http://purl.obolibrary.org/obo/HP_0004878	Intercostal muscle weakness	http://purl.obolibrary.org/obo/HP_0002093	Respiratory insufficiency		Lack of strength of the intercostal muscles, i.e., of the muscle groups running along the ribs that create and move the chest wall.
http://purl.obolibrary.org/obo/HP_0004879	Intermittent hyperventilation	http://purl.obolibrary.org/obo/HP_0002883	Hyperventilation		Episodic hyperventilation.
http://purl.obolibrary.org/obo/HP_0004880	Respiratory infections in early life	http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections		Increased susceptibility to respiratory infections in early life, as manifested by recurrent episodes of respiratory infections.
http://purl.obolibrary.org/obo/HP_0004887	Respiratory failure requiring assisted ventilation	http://purl.obolibrary.org/obo/HP_0002093	Respiratory insufficiency		A state of respiratory distress that requires a life saving intervention in the form of gaining airway access and instituting positive pressure ventilation.
http://purl.obolibrary.org/obo/HP_0004891	Recurrent infections due to aspiration	http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections		Increased susceptibility to infections due to aspiration, as manifested by recurrent episodes of infections due to aspiration.
http://purl.obolibrary.org/obo/HP_0004897	Stress/infection-induced lactic acidosis	http://purl.obolibrary.org/obo/HP_0003128	Lactic acidosis		A form of lactic acidemia that occurs in relation to stress or infection.
http://purl.obolibrary.org/obo/HP_0004898	Persistent lactic acidosis	http://purl.obolibrary.org/obo/HP_0003128	Lactic acidosis		A continuous form of lactic acidemia.
http://purl.obolibrary.org/obo/HP_0004900	Severe lactic acidosis	http://purl.obolibrary.org/obo/HP_0003128	Lactic acidosis		A severe form of lactic acidemia.
http://purl.obolibrary.org/obo/HP_0004901	Exercise-induced lactic acidemia	http://purl.obolibrary.org/obo/HP_0003128	Lactic acidosis		A form of lactic acidemia that occurs following exercise or exertion.
http://purl.obolibrary.org/obo/HP_0004902	Congenital lactic acidosis	http://purl.obolibrary.org/obo/HP_0003128	Lactic acidosis		A form of lactic acidemia with congenital onset.
http://purl.obolibrary.org/obo/HP_0004904	Maturity-onset diabetes of the young	http://purl.obolibrary.org/obo/HP_0000819	Diabetes mellitus		The term Maturity-onset diabetes of the young (MODY) was initially used for patients diagnosed with fasting hyperglycemia that could be treated without insulin for more than two years, where the initial diagnosis was made at a young age (under 25 years). Thus, MODY combines characteristics of type 1 diabetes (young age at diagnosis) and type 2 diabetes (less insulin dependence than type 1 diabetes). The term MODY is now most often used to refer to a group of monogenic diseases with these characteristics. Here, the term is used to describe hyperglycemia diagnosed at a young age with no or minor insulin dependency, no evidence of insulin resistance, and lack of evidence of autoimmune destruction of the beta cells.
http://purl.obolibrary.org/obo/HP_0004905	Reduced circulating vitamin A concentration	http://purl.obolibrary.org/obo/HP_0008372	Abnormal circulating vitamin A concentration		Concentration of vitamin A below the lower limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004911	Episodic metabolic acidosis	http://purl.obolibrary.org/obo/HP_0001942	Metabolic acidosis		Repeated transient episodes of metabolic acidosis, that is, of the buildup of acid or depletion of base due to accumulation of metabolic acids.
http://purl.obolibrary.org/obo/HP_0004913	Intermittent lactic acidemia	http://purl.obolibrary.org/obo/HP_0003128	Lactic acidosis		An intermittent (discontinuous) form of lactic acidemia.
http://purl.obolibrary.org/obo/HP_0004914	Recurrent infantile hypoglycemia	http://purl.obolibrary.org/obo/HP_0001988	Recurrent hypoglycemia		Recurrent episodes of decreased concentration of glucose in the blood occurring during the infantile period.
http://purl.obolibrary.org/obo/HP_0004915	Impairment of galactose metabolism	http://purl.obolibrary.org/obo/HP_0032245	Abnormal metabolism		An impairment of galactose metabolism.
http://purl.obolibrary.org/obo/HP_0004918	Hyperchloremic metabolic acidosis	http://purl.obolibrary.org/obo/HP_0001995	Hyperchloremic acidosis		A form of metabolic acidosis with increased serum chloride levels.
http://purl.obolibrary.org/obo/HP_0004923	Hyperphenylalaninemia	http://purl.obolibrary.org/obo/HP_0010893	Abnormal circulating phenylalanine concentration		The concentration of L-phenylalanine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0004924	Abnormal oral glucose tolerance	http://purl.obolibrary.org/obo/HP_0040270	Impaired glucose tolerance		An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral administration of glucose.
http://purl.obolibrary.org/obo/HP_0004925	Chronic lactic acidosis	http://purl.obolibrary.org/obo/HP_0012468	Chronic acidosis		A chronic form of lactic acidemia.
http://purl.obolibrary.org/obo/HP_0004927	Pulmonary artery dilatation	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		An abnormal widening of the diameter of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004931	Arteriosclerosis of small cerebral arteries	http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology		Arteriosclerosis (increased thickness, increased stiffness, loss of elasticity) of the small arteries of the brain.
http://purl.obolibrary.org/obo/HP_0004933	Ascending aortic dissection	http://purl.obolibrary.org/obo/HP_0031784	Abnormal ascending aorta morphology		A separation of the layers within the wall of the ascending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space.
http://purl.obolibrary.org/obo/HP_0004935	Pulmonary artery atresia	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		A congenital anomaly with a narrowing or complete absence of the opening between the right ventricle and the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004937	Pulmonary artery aneurysm	http://purl.obolibrary.org/obo/HP_0004927	Pulmonary artery dilatation		An aneurysm (severe localized balloon-like outward bulging) in the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004938	Tortuous cerebral arteries	http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology		Excessive bending, twisting, and winding of a cerebral artery.
http://purl.obolibrary.org/obo/HP_0004940	Generalized arterial calcification	http://purl.obolibrary.org/obo/HP_0003207	Arterial calcification		Calcification, that is, pathological deposition of calcium salts, affecting arteries distributed throughout the body.
http://purl.obolibrary.org/obo/HP_0004941	Extrahepatic portal hypertension	http://purl.obolibrary.org/obo/HP_0001409	Portal hypertension		Increased pressure in the pre-hepatic portal vein.
http://purl.obolibrary.org/obo/HP_0004942	Aortic aneurysm	http://purl.obolibrary.org/obo/HP_0002617	Vascular dilatation		Aortic dilatation refers to a dimension that is greater than the 95th percentile for the normal person age, sex and body size. In contrast, an aneurysm is defined as a localized dilation of the aorta that is more than 150 percent of predicted (ratio of observed to expected diameter 1.5 or more). Aneurysm should be distinguished from ectasia, which represents a diffuse dilation of the aorta less than 50 percent of normal aorta diameter.
http://purl.obolibrary.org/obo/HP_0004943	Accelerated atherosclerosis	http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis		Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors.
http://purl.obolibrary.org/obo/HP_0004944	Dilatation of the cerebral artery	http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology		The presence of a localized dilatation or ballooning of a cerebral artery.
http://purl.obolibrary.org/obo/HP_0004945	Extracranial internal carotid artery dissection	http://purl.obolibrary.org/obo/HP_0012159	Internal carotid artery dissection		A separation (dissection) of the layers of the extracranial portion of the internal carotid artery wall.
http://purl.obolibrary.org/obo/HP_0004948	Vascular tortuosity	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		Abnormal twisting of arteries or veins.
http://purl.obolibrary.org/obo/HP_0004950	Peripheral arterial stenosis	http://purl.obolibrary.org/obo/HP_0100545	Arterial stenosis		Narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quantified as an ankle-brachial index of less than 0.9, and may be manifested clinically as claudication.
http://purl.obolibrary.org/obo/HP_0004952	Pulmonary arteriovenous fistulas	http://purl.obolibrary.org/obo/HP_0004947	Arteriovenous fistula		A rare vascular anomaly with a direct communication between pulmonary artery and pulmonary vein without an intervening capillary bed.
http://purl.obolibrary.org/obo/HP_0004955	Generalized arterial tortuosity	http://purl.obolibrary.org/obo/HP_0005116	Arterial tortuosity		Abnormal tortuous (i.e., twisted) form of arteries affecting most or all arteries.
http://purl.obolibrary.org/obo/HP_0004959	Descending thoracic aorta aneurysm	http://purl.obolibrary.org/obo/HP_0012727	Thoracic aortic aneurysm		An abnormal localized widening (dilatation) of the descending thoracic aorta.
http://purl.obolibrary.org/obo/HP_0004960	Absent pulmonary artery	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		A congenital defect with aplasia (absence) of one of the right or left pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004961	Pulmonary artery sling	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		An anomalous origin of the left pulmonary artery, such that it arises from the posterior aspect of the right pulmonary artery and passes between the trachea and esophagus to reach the left hilum.
http://purl.obolibrary.org/obo/HP_0004962	Thoracic aorta calcification	http://purl.obolibrary.org/obo/HP_0004963	Calcification of the aorta		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the thoracic aorta.
http://purl.obolibrary.org/obo/HP_0004963	Calcification of the aorta	http://purl.obolibrary.org/obo/HP_0003207	Arterial calcification		Calcification, that is, pathological deposition of calcium salts in the aorta.
http://purl.obolibrary.org/obo/HP_0004964	Pulmonary arterial medial hypertrophy	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Increase in mass of the tunica media of the arteries in the pulmonary circulation.
http://purl.obolibrary.org/obo/HP_0004966	Medial calcification of large arteries	http://purl.obolibrary.org/obo/HP_0012456	Medial arterial calcification		Calcification, that is, pathological deposition of calcium salts in the tunica media of large (conduit) arteries.
http://purl.obolibrary.org/obo/HP_0004968	Recurrent cerebral hemorrhage	http://purl.obolibrary.org/obo/HP_0001342	Cerebral hemorrhage		Recurrent bleeding into the parenchyma of the brain.
http://purl.obolibrary.org/obo/HP_0004969	Peripheral pulmonary artery stenosis	http://purl.obolibrary.org/obo/HP_0004415	Pulmonary artery stenosis		Stenosis of a peripheral branch of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004970	Ascending tubular aorta aneurysm	http://purl.obolibrary.org/obo/HP_0012727	Thoracic aortic aneurysm		An abnormal localized widening (dilatation) of the tubular part of the ascending aorta.
http://purl.obolibrary.org/obo/HP_0004971	Pulmonary artery hypoplasia	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Underdevelopment of the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0004972	Elevated mean arterial pressure	http://purl.obolibrary.org/obo/HP_0032263	Increased blood pressure		An abnormal increase in the average blood pressure in an individual during a single cardiac cycle.
http://purl.obolibrary.org/obo/HP_0004974	Coarctation of abdominal aorta	http://purl.obolibrary.org/obo/HP_0001680	Coarctation of aorta		Coarctation of the aorta is a narrowing or constriction of a segment of the abdominal aorta.
http://purl.obolibrary.org/obo/HP_0004975	Erlenmeyer flask deformity of the femurs	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		Flaring of distal femur.
http://purl.obolibrary.org/obo/HP_0004977	Bilateral radial aplasia	http://purl.obolibrary.org/obo/HP_0003974	Absent radius		Missing radius bone on both sides associated with congenital failure of development.
http://purl.obolibrary.org/obo/HP_0004979	Metaphyseal sclerosis	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Abnormally increased density of metaphyseal bone.
http://purl.obolibrary.org/obo/HP_0004980	Metaphyseal rarefaction	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Reduction in density of metaphyseal bony tissue.
http://purl.obolibrary.org/obo/HP_0004987	Mesomelic leg shortening	http://purl.obolibrary.org/obo/HP_0003027	Mesomelia		Shortening of the middle parts of the leg in relation to the upper and terminal segments.
http://purl.obolibrary.org/obo/HP_0004991	Rhizomelic arm shortening	http://purl.obolibrary.org/obo/HP_0008905	Rhizomelia		Disproportionate shortening of the proximal segment of the arm (i.e. the humerus).
http://purl.obolibrary.org/obo/HP_0004993	Slender long bones with narrow diaphyses	http://purl.obolibrary.org/obo/HP_0003100	Slender long bone		Reduced diameter of a long bone with a more pronounced reduction of the diameter of the diaphysis of the long bones.
http://purl.obolibrary.org/obo/HP_0005001	Recurrent patellar dislocation	http://purl.obolibrary.org/obo/HP_0031869	Recurrent joint dislocation		Patellar dislocation occurring repeated times.
http://purl.obolibrary.org/obo/HP_0005004	Flattened proximal radial epiphyses	http://purl.obolibrary.org/obo/HP_0010597	Abnormality of the distal radial epiphysis		An abnormally flat form of the proximal epiphysis of the radius.
http://purl.obolibrary.org/obo/HP_0005005	Femoral bowing present at birth, straightening with time	http://purl.obolibrary.org/obo/HP_0002980	Femoral bowing		Congenital onset bending or abnormal curvature of the femur that normalizes with age.
http://purl.obolibrary.org/obo/HP_0005009	Dumbbell-shaped humerus	http://purl.obolibrary.org/obo/HP_0000947	Dumbbell-shaped long bone		The humerus is shortened and displays flaring (widening) of the metaphyses.
http://purl.obolibrary.org/obo/HP_0005011	Mesomelic arm shortening	http://purl.obolibrary.org/obo/HP_0003027	Mesomelia		Shortening of the middle parts of the arm in relation to the upper and terminal segments.
http://purl.obolibrary.org/obo/HP_0005013	Dysplastic distal radial epiphyses	http://purl.obolibrary.org/obo/HP_0010597	Abnormality of the distal radial epiphysis		Abnormally developed (dysplastic) distal epiphysis of the radius.
http://purl.obolibrary.org/obo/HP_0005019	Diaphyseal undertubulation	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		Tubulation refers to the size and shape of tubular bones. In children and adolescents, the modeling process regulates normal bone growth. Final shaft (tube) diameter depends on appositional bone growth and the equilibrium between periosteal and endosteal bone resorption and formation. Undertubulation refers to a broad, widened form of the shafts (diaphyses) of long bones.
http://purl.obolibrary.org/obo/HP_0005025	Hypoplastic distal humeri	http://purl.obolibrary.org/obo/HP_0006507	Aplasia/hypoplasia of the humerus		Underdevelopment of the distal portion of the humerus.
http://purl.obolibrary.org/obo/HP_0005033	Distal ulnar hypoplasia	http://purl.obolibrary.org/obo/HP_0003022	Hypoplasia of the ulna		Underdevelopment of the distal portion of the ulna.
http://purl.obolibrary.org/obo/HP_0005035	Shortening of all phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		Developmental hypoplasia (shortening) of all phalanges of the foot.
http://purl.obolibrary.org/obo/HP_0005036	Unilateral ulnar hypoplasia	http://purl.obolibrary.org/obo/HP_0003022	Hypoplasia of the ulna		Underdevelopment of the ulna on only one side.
http://purl.obolibrary.org/obo/HP_0005037	Proximal radio-ulnar synostosis	http://purl.obolibrary.org/obo/HP_0002974	Radioulnar synostosis		An abnormal osseous union (fusion) between the proximal portions of the radius and the ulna.
http://purl.obolibrary.org/obo/HP_0005039	Multiple long-bone exostoses	http://purl.obolibrary.org/obo/HP_0002762	Multiple exostoses		Multiple exostoses originating in long bones.
http://purl.obolibrary.org/obo/HP_0005041	Irregular capital femoral epiphysis	http://purl.obolibrary.org/obo/HP_0006361	Irregular femoral epiphysis		Irregular surface of the normally relatively smooth capital femoral epiphysis.
http://purl.obolibrary.org/obo/HP_0005043	Proximal humeral metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0003913	Humeral metaphyseal irregularity		Irregularity of the normally smooth surface of the metaphysis at the proximal end of the humerus (at the shoulder).
http://purl.obolibrary.org/obo/HP_0005045	Diaphyseal cortical sclerosis	http://purl.obolibrary.org/obo/HP_0003034	Diaphyseal sclerosis		An elevation in bone density of the cortex of one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0005050	Anterolateral radial head dislocation	http://purl.obolibrary.org/obo/HP_0003083	Dislocated radial head		A dislocation of the head of the radius from its socket in the elbow joint in an anterolateral direction.
http://purl.obolibrary.org/obo/HP_0005067	Proximal fibular overgrowth	http://purl.obolibrary.org/obo/HP_0003099	Fibular overgrowth		Overgrowth of the proximal part of the fibula.
http://purl.obolibrary.org/obo/HP_0005070	Proximal radial head dislocation	http://purl.obolibrary.org/obo/HP_0003083	Dislocated radial head		A dislocation of the head of the radius from its socket in the elbow joint in an proximal direction.
http://purl.obolibrary.org/obo/HP_0005072	Wrist hypermobility	http://purl.obolibrary.org/obo/HP_0430046	Small joint hypermobility		The ability of the wrist joints to move beyond their normal range of motion.
http://purl.obolibrary.org/obo/HP_0005084	Anterior radial head dislocation	http://purl.obolibrary.org/obo/HP_0003083	Dislocated radial head		A dislocation of the head of the radius from its socket in the elbow joint in an anterior direction.
http://purl.obolibrary.org/obo/HP_0005085	Limited knee flexion/extension	http://purl.obolibrary.org/obo/HP_0010501	Limitation of knee mobility		A limited ability of the knee joint to perform extension and flexion.
http://purl.obolibrary.org/obo/HP_0005090	Lateral femoral bowing	http://purl.obolibrary.org/obo/HP_0002980	Femoral bowing		A lateral bending or abnormal curvature of the femur.
http://purl.obolibrary.org/obo/HP_0005092	Streaky metaphyseal sclerosis	http://purl.obolibrary.org/obo/HP_0004979	Metaphyseal sclerosis		The presence of streaks (bands) of abnormally increased density of metaphyseal bone.
http://purl.obolibrary.org/obo/HP_0005093	Absent proximal radial epiphyses	http://purl.obolibrary.org/obo/HP_0010596	Abnormal proximal radial epiphysis morphology		Absence of the proximal radial epiphysis.
http://purl.obolibrary.org/obo/HP_0005096	Distal femoral bowing	http://purl.obolibrary.org/obo/HP_0002980	Femoral bowing		A bending or abnormal curvature of the distal portion of the femur.
http://purl.obolibrary.org/obo/HP_0005101	High-frequency hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A type of hearing impairment affecting primarily the higher frequencies of sound (3,000 to 6,000 Hz).
http://purl.obolibrary.org/obo/HP_0005102	Cochlear degeneration	http://purl.obolibrary.org/obo/HP_0000375	Abnormal cochlea morphology		Deterioration or loss of the tissues of the cochlea.
http://purl.obolibrary.org/obo/HP_0005103	Calcification of the auricular cartilage	http://purl.obolibrary.org/obo/HP_0100593	Calcification of cartilage		Ossification affecting the external ear cartilage.
http://purl.obolibrary.org/obo/HP_0005104	Hypoplastic nasal septum	http://purl.obolibrary.org/obo/HP_0009935	Aplasia/Hypoplasia of the nasal septum		Underdevelopment of the nasal septum.
http://purl.obolibrary.org/obo/HP_0005110	Atrial fibrillation	http://purl.obolibrary.org/obo/HP_0001692	Atrial arrhythmia		An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute.
http://purl.obolibrary.org/obo/HP_0005112	Abdominal aortic aneurysm	http://purl.obolibrary.org/obo/HP_0004942	Aortic aneurysm		An abnormal localized widening (dilatation) of the abdominal aorta.
http://purl.obolibrary.org/obo/HP_0005113	Aortic arch aneurysm	http://purl.obolibrary.org/obo/HP_0012727	Thoracic aortic aneurysm		An abnormal localized widening (dilatation) of the aortic arch.
http://purl.obolibrary.org/obo/HP_0005115	Supraventricular arrhythmia	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm.
http://purl.obolibrary.org/obo/HP_0005117	Elevated diastolic blood pressure	http://purl.obolibrary.org/obo/HP_0032263	Increased blood pressure		Abnormal increase in diastolic blood pressure.
http://purl.obolibrary.org/obo/HP_0005121	Posterior scalloping of vertebral bodies	http://purl.obolibrary.org/obo/HP_0004586	Biconcave vertebral bodies		An excessive concavity of the posterior surface of one or more vertebral bodies.
http://purl.obolibrary.org/obo/HP_0005133	Right ventricular dilatation	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		Enlargement of the chamber of the right ventricle, which can be defined echocardiographically as a right ventricular to left ventricular ratio greater than 1:1.
http://purl.obolibrary.org/obo/HP_0005134	Absence of the pulmonary valve	http://purl.obolibrary.org/obo/HP_0001641	Abnormal pulmonary valve morphology		Refers to the specific combination of defects with a severely dysplastic pulmonary valve and massively dilated branch pulmonary arteries.
http://purl.obolibrary.org/obo/HP_0005135	Abnormal T-wave	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		An abnormality of the T wave on the electrocardiogram, which mainly represents the repolarization of the ventricles.
http://purl.obolibrary.org/obo/HP_0005136	Mitral annular calcification	http://purl.obolibrary.org/obo/HP_0004382	Mitral valve calcification		Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus.
http://purl.obolibrary.org/obo/HP_0005143	Anomalous origin of right pulmonary artery from ascending aorta	http://purl.obolibrary.org/obo/HP_0011660	Anomalous origin of one pulmonary artery from ascending aorta		The right pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery.
http://purl.obolibrary.org/obo/HP_0005144	Ventricular septal hypertrophy	http://purl.obolibrary.org/obo/HP_0010438	Abnormal ventricular septum morphology		The dividing wall between left and right sides of the heart, thickens and bulges into the left ventricle.
http://purl.obolibrary.org/obo/HP_0005145	Coronary artery stenosis	http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology		Abnormal narrowing of the coronary artery.
http://purl.obolibrary.org/obo/HP_0005146	Cardiac valve calcification	http://purl.obolibrary.org/obo/HP_0011915	Cardiovascular calcification		Abnormal calcification of a cardiac valve.
http://purl.obolibrary.org/obo/HP_0005148	Pulmonary valve defects	http://purl.obolibrary.org/obo/HP_0001641	Abnormal pulmonary valve morphology		Any defect in the valve connecting the heart and the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0005151	Preductal coarctation of the aorta	http://purl.obolibrary.org/obo/HP_0012305	Coarctation of the descending aortic arch		Narrowing or constriction of the aorta localized proximal to the ductus arteriosus, i.e., to the preductal region of aortic arch.
http://purl.obolibrary.org/obo/HP_0005152	Histiocytoid cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy		A type of cardiomyopathy characterized pathologically by hamartomatous lesions of cardiac Purkinje cells.
http://purl.obolibrary.org/obo/HP_0005155	Ventricular escape rhythm	http://purl.obolibrary.org/obo/HP_0004308	Ventricular arrhythmia		A ventricular escape rhythm occurs whenever higher-lever pacemakers in AV junction or sinus node fail to control ventricular activation. Escape rate is usually 20-40 bpm, often associated with broad QRS complexes (at least 120 ms).
http://purl.obolibrary.org/obo/HP_0005156	Hypoplastic left atrium	http://purl.obolibrary.org/obo/HP_0025579	Abnormal left atrium morphology		Underdeveloped, small left heart atrium
http://purl.obolibrary.org/obo/HP_0005157	Concentric hypertrophic cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001639	Hypertrophic cardiomyopathy		Hypertrophic cardiomyopathy with an symmetrical and concentric pattern of hypertrophy.
http://purl.obolibrary.org/obo/HP_0005160	Total anomalous pulmonary venous return	http://purl.obolibrary.org/obo/HP_0010772	Anomalous pulmonary venous return		Total anomalous pulmonary venous return refers to a congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium.
http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function	http://purl.obolibrary.org/obo/HP_0030872	Abnormal cardiac ventricular function		Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole.
http://purl.obolibrary.org/obo/HP_0005164	Dysplastic pulmonary valve	http://purl.obolibrary.org/obo/HP_0001641	Abnormal pulmonary valve morphology		A congenital malformation of the pulmonary valve characterized by leaflet deformation.
http://purl.obolibrary.org/obo/HP_0005165	Shortened PR interval	http://purl.obolibrary.org/obo/HP_0031593	Abnormal PR interval		Reduced time for the PR interval (beginning of the P wave to the beginning of the QRS complex). In adults, normal values are 120 to 200 ms long.
http://purl.obolibrary.org/obo/HP_0005168	Elevated right atrial pressure	http://purl.obolibrary.org/obo/HP_0025443	Abnormal cardiac atrial physiology		An abnormal increase in magnitude of the pressure in the right atrium.
http://purl.obolibrary.org/obo/HP_0005170	Complete heart block with broad QRS complexes	http://purl.obolibrary.org/obo/HP_0001709	Third degree atrioventricular block		A type of third degree heart block in which the escape rhythm arises at a relatively low part of the conduction system (below the atrioventricular node), which produces a wide QRS complex.
http://purl.obolibrary.org/obo/HP_0005172	Left posterior fascicular block	http://purl.obolibrary.org/obo/HP_0011713	Left bundle branch block		Conduction block in the posterior division of the left bundle branch of the bundle of His.
http://purl.obolibrary.org/obo/HP_0005174	Membranous subvalvular aortic stenosis	http://purl.obolibrary.org/obo/HP_0001682	Subvalvular aortic stenosis		Subvalvular stenosis is caused by a diaphragm-like membrane. The stenosis is clinically manifested like any other form of aortic stenosis but is often associated with some aortic insufficiency.
http://purl.obolibrary.org/obo/HP_0005176	Dysplastic aortic valve	http://purl.obolibrary.org/obo/HP_0001646	Abnormal aortic valve morphology		A congenital malformation of the aortic valve characterized by leaflet deformation.
http://purl.obolibrary.org/obo/HP_0005177	Premature arteriosclerosis	http://purl.obolibrary.org/obo/HP_0002634	Arteriosclerosis		Arteriosclerosis occurring at an age that is younger than usual.
http://purl.obolibrary.org/obo/HP_0005178	Complete heart block with narrow QRS complexes	http://purl.obolibrary.org/obo/HP_0001709	Third degree atrioventricular block		A type of third degree heart block in which the escape rhythm arises at the atrioventricular node, which produces a narrow QRS complex.
http://purl.obolibrary.org/obo/HP_0005180	Tricuspid regurgitation	http://purl.obolibrary.org/obo/HP_0031651	Abnormal tricuspid valve physiology		Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium.
http://purl.obolibrary.org/obo/HP_0005181	Premature coronary artery atherosclerosis	http://purl.obolibrary.org/obo/HP_0001677	Coronary artery atherosclerosis		Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries before age of 45.
http://purl.obolibrary.org/obo/HP_0005182	Bicuspid pulmonary valve	http://purl.obolibrary.org/obo/HP_0031566	Abnormal pulmonary valve cusp morphology		The presence of a bicuspid pulmonary valve.
http://purl.obolibrary.org/obo/HP_0005183	Pericardial lymphangiectasia	http://purl.obolibrary.org/obo/HP_0031842	Lymphangiectasis		An abnormal dilatation of lymph vessels in the pericardium.
http://purl.obolibrary.org/obo/HP_0005184	Prolonged QTc interval	http://purl.obolibrary.org/obo/HP_0001657	Prolonged QT interval		A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.
http://purl.obolibrary.org/obo/HP_0005185	Global systolic dysfunction	http://purl.obolibrary.org/obo/HP_0006673	Reduced systolic function		A reduced ejection fraction and an enlarged left ventricle chamber, the latter by an increased resistance to filling with increased filling pressures. Systolic dysfunction is clinically associated with left ventricular failure in the presence of marked cardiomegaly.
http://purl.obolibrary.org/obo/HP_0005186	Synovial lining hyperplasia	http://purl.obolibrary.org/obo/HP_0005262	Abnormal synovial membrane morphology		Synovial hyperplasia involves proliferation of mesenchymal stromal/stem cells and leads to synovial thickening, which can be observed radiographically.
http://purl.obolibrary.org/obo/HP_0005194	Flattened metatarsal heads	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		Abnormally flat shape of the heads of the metatarsal bones.
http://purl.obolibrary.org/obo/HP_0005197	Generalized morning stiffness	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of stiffness in the joints that occurs following waking up in the morning.
http://purl.obolibrary.org/obo/HP_0005198	Stiff interphalangeal joints	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		Interphalangeal joint stiffness is a perceived sensation of tightness in the interphalangeal joints when attempting to move them after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0005199	Aplasia of the abdominal wall musculature	http://purl.obolibrary.org/obo/HP_0010318	Aplasia/Hypoplasia of the abdominal wall musculature		Absence of the abdominal musculature.
http://purl.obolibrary.org/obo/HP_0005202	Helicobacter pylori infection	http://purl.obolibrary.org/obo/HP_0004798	Recurrent infection of the gastrointestinal tract		A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach.
http://purl.obolibrary.org/obo/HP_0005203	Spontaneous esophageal perforation	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		The occurrence of the full-thickness tear (perforation) of the wall of the esophagus.
http://purl.obolibrary.org/obo/HP_0005206	Pancreatic pseudocyst	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Cyst-like space not lined by epithelium and contained within the pancreas. Pancreatic pseudocysts are often associated with pancreatitis.
http://purl.obolibrary.org/obo/HP_0005207	Gastric hypertrophy	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		Hypertrophy of the stomach.
http://purl.obolibrary.org/obo/HP_0005208	Secretory diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption.
http://purl.obolibrary.org/obo/HP_0005209	Intrahepatic bile duct cysts	http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology		The presence of cyst of the intrahepatic bile duct.
http://purl.obolibrary.org/obo/HP_0005210	Hypoplastic colon	http://purl.obolibrary.org/obo/HP_0100811	Aplasia/Hypoplasia of the colon		Underdevelopment of the colon.
http://purl.obolibrary.org/obo/HP_0005212	Anal mucosal leukoplakia	http://purl.obolibrary.org/obo/HP_0032186	Anal neoplasm		Leukoplakia is a precancerous dermatosis of mucous membranes analogous Leukoplakia is basically a chronic inflammatory hypertrophy in which anaplasia and malignant dyskeratosis may develop and subsequently advance to an invasive squamous cell cancer. The clinical diagnosis of primary anal leukoplakia is indicated by single or multiple slightly raised,irregular, marginated, grayish-white keratinized' patches in the anal canal. Tissue biopsy is necessary for confirmation.
http://purl.obolibrary.org/obo/HP_0005213	Pancreatic calcification	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		The presence of abnormal calcium deposition lesions in the pancreas.
http://purl.obolibrary.org/obo/HP_0005215	Frequent Giardia lamblia infestation	http://purl.obolibrary.org/obo/HP_0004798	Recurrent infection of the gastrointestinal tract		Increased susceptibility to Giardia lamblia infection of the intestine, as manifested by a medical history of multiple episodes of Giardia lamblia intestinal infection.
http://purl.obolibrary.org/obo/HP_0005216	Impaired mastication	http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology		An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing.
http://purl.obolibrary.org/obo/HP_0005217	Abdominal organ duplication	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		A congenital malformation characterized by the development of an additional organ or organ-like structure, i.e., an extra copy of the organ normally located in the abdomen.
http://purl.obolibrary.org/obo/HP_0005218	Anoperineal fistula	http://purl.obolibrary.org/obo/HP_0010447	Anal fistula		The presence of a fistula (abnormal tunnel) between the anal canal and the perineum.
http://purl.obolibrary.org/obo/HP_0005219	Absence of intrinsic factor	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		Absence of gastric intrinsic factor, which is normally produced by the parietal cells of the stomach, and is required for the absorption of vitamin B12.
http://purl.obolibrary.org/obo/HP_0005224	Rectal abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A collection of pus in the area of the rectum.
http://purl.obolibrary.org/obo/HP_0005225	Intestinal edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Accumulation of cell free, noninflammatony fluid within the wall of the intestinal tract producing uniform thickening of the mucosal folds.
http://purl.obolibrary.org/obo/HP_0005227	Adenomatous colonic polyposis	http://purl.obolibrary.org/obo/HP_0100273	Neoplasm of the colon		Presence of multiple adenomatous polyps in the colon.
http://purl.obolibrary.org/obo/HP_0005230	Biliary tract obstruction	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Obstruction affecting the biliary tree.
http://purl.obolibrary.org/obo/HP_0005232	Pancreatic dysplasia	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		The presence of developmental dysplasia of the pancreas.
http://purl.obolibrary.org/obo/HP_0005233	Hypoplasia of the gallbladder	http://purl.obolibrary.org/obo/HP_0011466	Aplasia/Hypoplasia of the gallbladder		The presence of a hypoplastic gallbladder.
http://purl.obolibrary.org/obo/HP_0005235	Jejunal atresia	http://purl.obolibrary.org/obo/HP_0005265	Abnormal jejunum morphology		A developmental defect resulting in abnormal closure, or atresia of the tubular structure of the jejunum.
http://purl.obolibrary.org/obo/HP_0005236	Chronic calcifying pancreatitis	http://purl.obolibrary.org/obo/HP_0001733	Pancreatitis		A form of chronic pancreatitis that is characterized by calcification.
http://purl.obolibrary.org/obo/HP_0005237	Degenerative liver disease	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		The presence of degenerative changes of the liver.
http://purl.obolibrary.org/obo/HP_0005241	Total intestinal aganglionosis	http://purl.obolibrary.org/obo/HP_0004362	Abnormal enteric ganglion morphology		A congenital defect characterized by the lack of ganglion cells in the entire intestine, i.e., the aganglionic segment comprises the entire large and small bowel.
http://purl.obolibrary.org/obo/HP_0005242	Extrahepatic biliary duct atresia	http://purl.obolibrary.org/obo/HP_0005912	Biliary atresia		Atresia in the extrahepatic bile duct.
http://purl.obolibrary.org/obo/HP_0005243	Partial abdominal muscle agenesis	http://purl.obolibrary.org/obo/HP_0010318	Aplasia/Hypoplasia of the abdominal wall musculature		Failure to form of portions of the abdominal musculature.
http://purl.obolibrary.org/obo/HP_0005245	Intestinal hypoplasia	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		Developmental hypoplasia of the intestine.
http://purl.obolibrary.org/obo/HP_0005246	Giant hypertrophic gastritis	http://purl.obolibrary.org/obo/HP_0005263	Gastritis		A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds.
http://purl.obolibrary.org/obo/HP_0005247	Hypoplasia of the abdominal wall musculature	http://purl.obolibrary.org/obo/HP_0010318	Aplasia/Hypoplasia of the abdominal wall musculature		Underdevelopment of the abdominal musculature.
http://purl.obolibrary.org/obo/HP_0005248	Intrahepatic biliary atresia	http://purl.obolibrary.org/obo/HP_0005912	Biliary atresia		Atresia in the intrahepatic bile duct.
http://purl.obolibrary.org/obo/HP_0005255	Absence of pectoralis minor muscle	http://purl.obolibrary.org/obo/HP_0011957	Abnormal pectoral muscle morphology		Aplasia (congenital absence) of the pectoralis minor.
http://purl.obolibrary.org/obo/HP_0005256	Unilateral absence of pectoralis major muscle	http://purl.obolibrary.org/obo/HP_0011957	Abnormal pectoral muscle morphology		Aplasia (congenital absence) of the pectoralis minor on only one side of the chest.
http://purl.obolibrary.org/obo/HP_0005259	Abnormal facility in opposing the shoulders	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		Increased range of shoulder movement related to aplasia or hypoplasia of the clavicles that results in the ability to approximate the shoulders in front of the chest.
http://purl.obolibrary.org/obo/HP_0005261	Joint hemorrhage	http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage		Hemorrhage occurring within a joint.
http://purl.obolibrary.org/obo/HP_0005262	Abnormal synovial membrane morphology	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		Any structural anomaly of the synovium, which is a membrane that lines the cavity of synovial joints and consists of a lining layer of macrophage-like synoviocytes and fibroblast-like synoviocytes, as well as a sublining of connective tissue. Synovial cells are thought to contribute to joint homeostasis by secreting various factors such as hyaluronic acid and lubricin important for joint lubrication and function, as well as disposing of the waste products.
http://purl.obolibrary.org/obo/HP_0005263	Gastritis	http://purl.obolibrary.org/obo/HP_0004295	Abnormal gastric mucosa morphology		The presence of inflammation of the gastric mucous membrane.
http://purl.obolibrary.org/obo/HP_0005264	Abnormality of the gallbladder	http://purl.obolibrary.org/obo/HP_0004297	Abnormality of the biliary system		An abnormality of the gallbladder.
http://purl.obolibrary.org/obo/HP_0005265	Abnormal jejunum morphology	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		An abnormality of the jejunum, i.e., of the middle section of the small intestine.
http://purl.obolibrary.org/obo/HP_0005266	Intestinal polyp	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A discrete abnormal tissue mass that protrudes into the lumen of the intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base.
http://purl.obolibrary.org/obo/HP_0005268	Miscarriage	http://purl.obolibrary.org/obo/HP_0034241	Prenatal death		A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 22th week of pregnancy.
http://purl.obolibrary.org/obo/HP_0005272	Prominent nasolabial fold	http://purl.obolibrary.org/obo/HP_0005289	Abnormal nasolabial region morphology		Exaggerated bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion, or commissure).
http://purl.obolibrary.org/obo/HP_0005273	Absent nasal septal cartilage	http://purl.obolibrary.org/obo/HP_0009935	Aplasia/Hypoplasia of the nasal septum		Lack of the cartilage of the nasal septum.
http://purl.obolibrary.org/obo/HP_0005280	Depressed nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		Posterior positioning of the nasal root in relation to the overall facial profile for age.
http://purl.obolibrary.org/obo/HP_0005294	Arterial dissection	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		A separation (dissection) of the layers of an artery.
http://purl.obolibrary.org/obo/HP_0005295	Pseudocoarctation of the aorta	http://purl.obolibrary.org/obo/HP_0012303	Abnormal aortic arch morphology		Pseudocoarctation is a congenital anomaly of kinking, or buckling, of the aorta without a pressure gradient across the lesion. It is characterized by elongation and kinking of the aorta at the level of the ligamentum arteriosum.
http://purl.obolibrary.org/obo/HP_0005297	Premature occlusive vascular stenosis	http://purl.obolibrary.org/obo/HP_0004950	Peripheral arterial stenosis		Peripheral arterial stenosis with onset before the age of 50 years.
http://purl.obolibrary.org/obo/HP_0005301	Persistent left superior vena cava	http://purl.obolibrary.org/obo/HP_0025575	Abnormal superior vena cava morphology		A rare congenital vascular anomaly that results when the left superior cardinal vein caudal to the innominate vein fails to regress.
http://purl.obolibrary.org/obo/HP_0005302	Carotid artery tortuosity	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		Abnormal tortuous (i.e., twisted) form of the carotid arteries.
http://purl.obolibrary.org/obo/HP_0005303	Aortic arch calcification	http://purl.obolibrary.org/obo/HP_0004962	Thoracic aorta calcification		Calcification, that is, pathological deposition of calcium salts in the arch of aorta.
http://purl.obolibrary.org/obo/HP_0005305	Cerebral venous thrombosis	http://purl.obolibrary.org/obo/HP_0004936	Venous thrombosis		Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow.
http://purl.obolibrary.org/obo/HP_0005310	Large vessel vasculitis	http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site		A type of vasculitis (inflammation of blood vessel walls) affecting large arteries such as the aorta and branches of the aorta.
http://purl.obolibrary.org/obo/HP_0005311	Agenesis of pulmonary vessels	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		A developmental defect characterized by the lack of formation of the pulmonary blood vessels.
http://purl.obolibrary.org/obo/HP_0005312	Pulmonary aterial intimal fibrosis	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries in the pulmonary circulation.
http://purl.obolibrary.org/obo/HP_0005313	Arterial fibromuscular dysplasia	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		An arterial lesion that is characterized by either intimal fibroplasia, with neointimal lesions of cells and matrix deposition, or medial fibroplasia, in which there is loss of smooth muscle cells and increased deposition of collagen and proteoglycans in the medial layer.
http://purl.obolibrary.org/obo/HP_0005317	Increased pulmonary vascular resistance	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		Pulmonary vascular resistance (PVR) more than 3 wood units, as defined by the current definition of pulmonary hypertension. 95% of individuals have a PVR of less than 2.4 wood units.
http://purl.obolibrary.org/obo/HP_0005318	Cerebral vasculitis	http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site		Inflammation of the blood vessels within the brain.
http://purl.obolibrary.org/obo/HP_0005321	Mandibulofacial dysostosis	http://purl.obolibrary.org/obo/HP_0004439	Craniofacial dysostosis		A type of craniofacial dysostosis associated with abnormalities of the external ears, mirognathia, macrostomia, coloboma of the lower eyelid, and cleft palate. This is a bundled term that is left in the HPO now for convenience with legacy annotations but should not be used for new annotations.
http://purl.obolibrary.org/obo/HP_0005323	Hemifacial hypertrophy	http://purl.obolibrary.org/obo/HP_0000324	Facial asymmetry		Unilateral overgrowth of facial tissues, including muscles, bones and skin.
http://purl.obolibrary.org/obo/HP_0005325	Extension of hair growth on temples to lateral eyebrow	http://purl.obolibrary.org/obo/HP_0000599	Abnormality of the frontal hairline		A pattern of hair growth in which there is hair extending from the temples to the lateral eyebrows.
http://purl.obolibrary.org/obo/HP_0005326	Hypoplastic philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Underdevelopment of the philtrum.
http://purl.obolibrary.org/obo/HP_0005328	Progeroid facial appearance	http://purl.obolibrary.org/obo/HP_0007495	Prematurely aged appearance		A degree of wrinkling of the facial skin that is more than expected for the age of the individual, leading to a prematurely aged appearance.
http://purl.obolibrary.org/obo/HP_0005332	Recurrent mandibular subluxations	http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation		Recurrent partial dislocations of the mandible.
http://purl.obolibrary.org/obo/HP_0005338	Sparse lateral eyebrow	http://purl.obolibrary.org/obo/HP_0045075	Sparse eyebrow		Decreased density/number and/or decreased diameter of lateral eyebrow hairs.
http://purl.obolibrary.org/obo/HP_0005339	Abnormality of complement system	http://purl.obolibrary.org/obo/HP_0005368	Abnormality of humoral immunity		An abnormality of the complement system.
http://purl.obolibrary.org/obo/HP_0005341	Autonomic bladder dysfunction	http://purl.obolibrary.org/obo/HP_0012332	Abnormal autonomic nervous system physiology		Abnormal bladder function (increased urge or frequency of urination or urge incontinence) resulting from abnormal functioning of the autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0005343	Hypoplasia of the bladder	http://purl.obolibrary.org/obo/HP_0010476	Aplasia/Hypoplasia of the bladder		Underdevelopment of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any structural abnormality of the carotid arteries, including the common carotid artery and its' arterial branches.
http://purl.obolibrary.org/obo/HP_0005345	Abnormal vena cava morphology	http://purl.obolibrary.org/obo/HP_0030962	Abnormal morphology of the great vessels		An abnormality of the structure of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava.
http://purl.obolibrary.org/obo/HP_0005347	Tracheal cartilaginous sleeve	http://purl.obolibrary.org/obo/HP_0004468	Anomalous tracheal cartilage		Tracheal cartilaginous sleeve (TCS) is a rare congenital airway malformation in which distinct tracheal rings are replaced by a continuous cartilaginous segment. Vertically fused C- or O-shaped cartilaginous rings can extend from the subglottis to the carina or bronchus with little to no pars membranacea posteriorly. Comment:Tracheal cartilaginous sleeve has been associated with various craniosynostosis syndromes.
http://purl.obolibrary.org/obo/HP_0005348	Inspiratory stridor	http://purl.obolibrary.org/obo/HP_0010307	Stridor		Inspiratory stridor is a high pitched sound upon inspiration that is generally related to laryngeal abnormalities.
http://purl.obolibrary.org/obo/HP_0005349	Hypoplasia of the epiglottis	http://purl.obolibrary.org/obo/HP_0010565	Aplasia/Hypoplasia of the Epiglottis		Hypoplasia of the epiglottis.
http://purl.obolibrary.org/obo/HP_0005352	Severe T-cell immunodeficiency	http://purl.obolibrary.org/obo/HP_0005374	Cellular immunodeficiency		A primary immune deficiency that is characterized by defects or deficiencies of T-lymphocytes that causes specific susceptibility to intracellular micro-organisms.
http://purl.obolibrary.org/obo/HP_0005353	Recurrent herpes	http://purl.obolibrary.org/obo/HP_0034318	Unusual virus reactivation		Increased susceptibility to herpesvirus, as manifested by recurrent episodes of herpesvirus.
http://purl.obolibrary.org/obo/HP_0005356	Decreased circulating complement factor I concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		Concentration of the complement component factor I in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0005357	Defective B cell differentiation	http://purl.obolibrary.org/obo/HP_0005384	Defective B cell activation		Reduced functionality of the process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
http://purl.obolibrary.org/obo/HP_0005359	Aplasia of the thymus	http://purl.obolibrary.org/obo/HP_0010515	Aplasia/Hypoplasia of the thymus		Absence of the thymus. This feature may be appreciated by the lack of a thymic shadow upon radiographic examination.
http://purl.obolibrary.org/obo/HP_0005360	Susceptibility to chickenpox	http://purl.obolibrary.org/obo/HP_0004429	Recurrent viral infections		Increased susceptibility to chicken pox, as manifested by recurrent episodes of chicken pox.
http://purl.obolibrary.org/obo/HP_0005363	Humoral immunodeficiency	http://purl.obolibrary.org/obo/HP_0002721	Immunodeficiency		A general term referring to a defect in immunity resulting from impaired antibody production.
http://purl.obolibrary.org/obo/HP_0005366	Recurrent streptococcus pneumoniae infections	http://purl.obolibrary.org/obo/HP_0020096	Recurrent streptococcal infections		Increased susceptibility to streptococcus pneumoniae infections as manifested by a history of recurrent infections by streptococcus pneumoniae.
http://purl.obolibrary.org/obo/HP_0005368	Abnormality of humoral immunity	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system.
http://purl.obolibrary.org/obo/HP_0005369	Decreased circulating complement factor H concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		Concentration of the complement component factor H in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0005374	Cellular immunodeficiency	http://purl.obolibrary.org/obo/HP_0002721	Immunodeficiency		An immunodeficiency characterized by defective cell-mediated immunity or humoral immunity.
http://purl.obolibrary.org/obo/HP_0005376	Recurrent Haemophilus influenzae infection	http://purl.obolibrary.org/obo/HP_5210070	Unusual Haemophilus influenzae infection		Increased susceptibility to Haemophilus influenzae infections as manifested by recurrent episodes of Haemophilus influenzae infection.
http://purl.obolibrary.org/obo/HP_0005381	Recurrent Neisseria meningitidis infection	http://purl.obolibrary.org/obo/HP_5210067	Unusual Neisseria meningitidis infection		Increased susceptibility to Neisseria meningitidis infections as manifested by recurrent episodes of Neisseria meningitidis infection.
http://purl.obolibrary.org/obo/HP_0005384	Defective B cell activation	http://purl.obolibrary.org/obo/HP_0005372	Abnormal B cell physiology		A reduced ability of a B cell to become activated, i.e., the change in morphology and behavior of
http://purl.obolibrary.org/obo/HP_0005386	Recurrent protozoan infections	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		Increased susceptibility to protozoan infections as manifested by recurrent episodes of protozoan infection.
http://purl.obolibrary.org/obo/HP_0005387	Combined immunodeficiency	http://purl.obolibrary.org/obo/HP_0002721	Immunodeficiency		A group of phenotypically heterogeneous genetic disorders characterized by profound deficiencies of T- and B-cell function, which predispose the patients to both infectious and noninfectious complications.
http://purl.obolibrary.org/obo/HP_0005389	Depletion of components of the alternative complement pathway	http://purl.obolibrary.org/obo/HP_0005482	Abnormality of the alternative complement pathway		An abnormal reduction in the components of the alternative complement pathway, such as the C3 protein or its cleavage products.
http://purl.obolibrary.org/obo/HP_0005390	Recurrent opportunistic infections	http://purl.obolibrary.org/obo/HP_0031690	Opportunistic infection		Increased susceptibility to opportunistic infections as manifested by recurrent episodes of infection by opportunistic agents, i.e., by microorganisms that do not usually cause disease in a healthy host, but are able to infect a host with a compromised immune system.
http://purl.obolibrary.org/obo/HP_0005396	Susceptibility to coronavirus 229e	http://purl.obolibrary.org/obo/HP_0004429	Recurrent viral infections		Increased susceptibility to coronavirus 229e, as manifested by recurrent episodes of coronavirus 229e.
http://purl.obolibrary.org/obo/HP_0005400	Reduction of neutrophil motility	http://purl.obolibrary.org/obo/HP_0011990	Abnormal neutrophil physiology		An abnormal reduction of the cell motility of neutrophils.
http://purl.obolibrary.org/obo/HP_0005401	Recurrent Candida infection	http://purl.obolibrary.org/obo/HP_5210102	Unusual Candida infection		Increased susceptibility to Candida infections as manifested by recurrent episodes of Candida infection.
http://purl.obolibrary.org/obo/HP_0005403	Decreased total T cell count	http://purl.obolibrary.org/obo/HP_5210411	Decreased total T cell number		Abnormal decrease in the absolute number of T cells, commonly characterized as CD3+ lymphocytes, per microliter of blood, compared to a reference range for a given sex and age-group. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_0005404	Increased total B cell count	http://purl.obolibrary.org/obo/HP_0010975	Abnormal total B cell count		The absolute number of B cells in the blood, per microlitre is above the upper limit of normal of the reference range for the appropriate sex and age-group.
http://purl.obolibrary.org/obo/HP_0005411	Chronic intestinal candidiasis	http://purl.obolibrary.org/obo/HP_0002728	Recurrent mucocutaneous candidiasis		Persistent overgrowth of Candida albicans in the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0005413	Elevated circulating alpha-globulin concentration	http://purl.obolibrary.org/obo/HP_0032311	Elevated circulating globulin concentration		The concentration of alpha-globulin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0005415	Decreased total CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_5210425	Decreased total CD8+ T cell number		Abnormal decrease of cytotoxic CD3+CD8+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0005416	Decreased circulating complement factor B concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		Concentration of the complement component factor B in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0005419	Decreased T cell activation	http://purl.obolibrary.org/obo/HP_0410035	Abnormal T cell activation		Decreased or impaired activation of T cells in response to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
http://purl.obolibrary.org/obo/HP_0005421	Decreased circulating complement C3 concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		Concentration of the complement component C3 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0005422	Absence of CD8+ T cells	http://purl.obolibrary.org/obo/HP_0005415	Decreased total CD8+ T cell proportion		Lack of detectible CD8-positive T cells
http://purl.obolibrary.org/obo/HP_0005423	Dysfunctional alternative complement pathway	http://purl.obolibrary.org/obo/HP_0005482	Abnormality of the alternative complement pathway		An abnormality of the functioning of any aspect of the alternative complement pathway.
http://purl.obolibrary.org/obo/HP_0005424	Absent specific antibody response	http://purl.obolibrary.org/obo/HP_0012475	Impaired specific antibody response		Inability of the immune system to produce targeted, protective antibodies (immunoglobulins) against specific pathogens or vaccines in the setting of normal or near-normal serum levels of total IgG, IgA, and IgM and normal absolute counts of B cells and T cells.
http://purl.obolibrary.org/obo/HP_0005425	Recurrent sinopulmonary infections	http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections		An increased susceptibility to infections involving both the paranasal sinuses and the lungs, as manifested by a history of recurrent sinopulmonary infections.
http://purl.obolibrary.org/obo/HP_0005429	Recurrent systemic pyogenic infections	http://purl.obolibrary.org/obo/HP_0002718	Recurrent bacterial infections		Increased susceptibility to systemic pyogenic infections as manifested by recurrent episodes of systemic pyogenic infections.
http://purl.obolibrary.org/obo/HP_0005430	Recurrent Neisserial infections	http://purl.obolibrary.org/obo/HP_0005420	Recurrent gram-negative bacterial infections		Recurrent infections by bacteria of the genus Neisseria, including N. meningitidis (one of the most common causes of bacterial meningitis).
http://purl.obolibrary.org/obo/HP_0005432	Transient hypogammaglobulinemia of infancy	http://purl.obolibrary.org/obo/HP_0004313	Decreased circulating immunoglobulin concentration		At birth, newborns are endowed with maternal antibodies. IgG production normally begins at the age of two months. A delay in recovery from this physiological hypogammaglobulinemia between the 3rd and the 6th month of life, and of recovery period between 18 and 36 months defines transient hypogammaglobulinemia of infancy.
http://purl.obolibrary.org/obo/HP_0005437	Recurrent infections in infancy and early childhood	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		Recurrent infections at an early age with improvement in later childhood.
http://purl.obolibrary.org/obo/HP_0005439	Maxillozygomatic hypoplasia	http://purl.obolibrary.org/obo/HP_0010669	Hypoplasia of the zygomatic bone		Hypoplasia of the maxillozygomatic complex.
http://purl.obolibrary.org/obo/HP_0005441	Sclerotic cranial sutures	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		An increased density in the cranial sutures following obliteration.
http://purl.obolibrary.org/obo/HP_0005442	Widely patent coronal suture	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		The presence of a coronal suture (the cranial suture that separates the frontal and parietal bones) that is not ossified but rather wide open at an age when it is normally closed.
http://purl.obolibrary.org/obo/HP_0005446	Obtuse angle of mandible	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		Abnormally flat (obtuse) angle of the mandible. The angle of the mandibular, located at the junction between the body and the ramus of the mandible, is normally close to being a right angle. This terms describes an abnormal increase of this angle such that the mandible appears flatter than normal.
http://purl.obolibrary.org/obo/HP_0005450	Calvarial osteosclerosis	http://purl.obolibrary.org/obo/HP_0005464	Craniofacial osteosclerosis		An increase in bone density affecting the calvaria (roof of the skull).
http://purl.obolibrary.org/obo/HP_0005456	Absent ethmoidal sinuses	http://purl.obolibrary.org/obo/HP_0002689	Absent paranasal sinuses		Lack (aplasia) of the ethmoidal sinus.
http://purl.obolibrary.org/obo/HP_0005458	Premature closure of fontanelles	http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology		Normally, the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior fontanelle closes by about the middle of the second year. This term refers to the situation in which the fontanelles close at an inappropriately early time point.
http://purl.obolibrary.org/obo/HP_0005462	Calcification of falx cerebri	http://purl.obolibrary.org/obo/HP_0010653	Abnormality of the falx cerebri		The presence of calcium deposition in the falx cerebri.
http://purl.obolibrary.org/obo/HP_0005464	Craniofacial osteosclerosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Abnormally increased density of craniofacial bone tissue.
http://purl.obolibrary.org/obo/HP_0005465	Facial hyperostosis	http://purl.obolibrary.org/obo/HP_0004493	Craniofacial hyperostosis		Excessive growth (overgrowth) of the facial bones, that is of the facial skeleton.
http://purl.obolibrary.org/obo/HP_0005466	Hypoplasia of the frontal bone	http://purl.obolibrary.org/obo/HP_0011218	Abnormal shape of the frontal region		Underdevelopment of the frontal bone.
http://purl.obolibrary.org/obo/HP_0005469	Flat occiput	http://purl.obolibrary.org/obo/HP_0011217	Abnormal shape of the occiput		Reduced convexity of the occiput (posterior part of skull).
http://purl.obolibrary.org/obo/HP_0005473	Fusion of middle ear ossicles	http://purl.obolibrary.org/obo/HP_0004452	Abnormality of the middle ear ossicles		Bony fusion of malleus, incus, and stapes.
http://purl.obolibrary.org/obo/HP_0005474	Decreased calvarial ossification	http://purl.obolibrary.org/obo/HP_0004331	Decreased skull ossification		Abnormal reduction in ossification of the calvaria (roof of the skull consisting of the frontal bone, parietal bones, temporal bones, and occipital bone).
http://purl.obolibrary.org/obo/HP_0005476	Widely patent sagittal suture	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		The presence of a sagittal suture (the cranial suture that separates the left and right parietal bones) that is not ossified but rather wide open at an age when it is normally closed.
http://purl.obolibrary.org/obo/HP_0005477	Progressive sclerosis of skull base	http://purl.obolibrary.org/obo/HP_0002694	Sclerosis of skull base		Progressively increasing bone density of the skull base without significant changes in bony contour.
http://purl.obolibrary.org/obo/HP_0005479	Decreased circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0410241	Abnormal circulating IgE concentration		An abnormally decreased level of immunoglobulin E (IgE) in blood.
http://purl.obolibrary.org/obo/HP_0005482	Abnormality of the alternative complement pathway	http://purl.obolibrary.org/obo/HP_0005339	Abnormality of complement system		A deviation in any aspect of the alternative complement pathway.
http://purl.obolibrary.org/obo/HP_0005483	Abnormal epiglottis morphology	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		An abnormality of the epiglottis.
http://purl.obolibrary.org/obo/HP_0005484	Secondary microcephaly	http://purl.obolibrary.org/obo/HP_0000252	Microcephaly		Head circumference which falls below 2 standard deviations below the mean for age and gender because of insufficient head growth after birth.
http://purl.obolibrary.org/obo/HP_0005486	Small fontanelle	http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology		A fontanelle that is small for age.
http://purl.obolibrary.org/obo/HP_0005487	Prominent metopic ridge	http://purl.obolibrary.org/obo/HP_0005556	Abnormality of the metopic suture		Vertical bony ridge positioned in the midline of the forehead.
http://purl.obolibrary.org/obo/HP_0005490	Postnatal macrocephaly	http://purl.obolibrary.org/obo/HP_0000256	Macrocephaly		The postnatal development of an abnormally large skull (macrocephaly).
http://purl.obolibrary.org/obo/HP_0005495	Metopic suture patent to nasal root	http://purl.obolibrary.org/obo/HP_0005556	Abnormality of the metopic suture		The frontal suture divides the two halves of the frontal bone in infants and usually fuses by the age of six years. The suture runs from the bregma (the point on the skull at which the coronal suture is intersected perpendicularly by the sagittal suture) to the nasion or nasal root. This term applies if the suture is widely patent from bregma to nasal root.
http://purl.obolibrary.org/obo/HP_0005506	Chronic myelogenous leukemia	http://purl.obolibrary.org/obo/HP_0005558	Chronic leukemia		A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate.
http://purl.obolibrary.org/obo/HP_0005507	Hemoglobin Barts	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Normal adult hemoglobin is composed of two chains each of alpha and beta globin. Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues.
http://purl.obolibrary.org/obo/HP_0005508	Monoclonal elevation of circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0005523	Lymphoproliferative disorder		Presence of a monoclonal immunoglobulin M protein in the serum.
http://purl.obolibrary.org/obo/HP_0005510	Transient erythroblastopenia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		A transient reduction in the number of erythroblasts in the circulation.
http://purl.obolibrary.org/obo/HP_0005511	Heinz body anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		Anemia characterized by abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells.
http://purl.obolibrary.org/obo/HP_0005513	Increased megakaryocyte count	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow.
http://purl.obolibrary.org/obo/HP_0005517	T-cell lymphoma/leukemia	http://purl.obolibrary.org/obo/HP_0012190	T-cell lymphoma		A type of T-cell lymphoma in which cancerous T-cells may present in the blood (leukemia), lymph nodes (lymphoma), skin or in multiple areas.
http://purl.obolibrary.org/obo/HP_0005518	Increased mean corpuscular volume	http://purl.obolibrary.org/obo/HP_0025065	Abnormal mean corpuscular volume		Larger than normal size of erythrocytes.
http://purl.obolibrary.org/obo/HP_0005520	Chronic disseminated intravascular coagulation	http://purl.obolibrary.org/obo/HP_0005521	Disseminated intravascular coagulation		A chronic form of disseminated intravascular coagulation in which a persistent weak or intermittent activating stimulus is present and destruction and production of coagulation factors and platelets are balanced.
http://purl.obolibrary.org/obo/HP_0005521	Disseminated intravascular coagulation	http://purl.obolibrary.org/obo/HP_0001977	Abnormal thrombosis		Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels.
http://purl.obolibrary.org/obo/HP_0005522	Pyridoxine-responsive sideroblastic anemia	http://purl.obolibrary.org/obo/HP_0001924	Sideroblastic anemia		A type of sideroblastic anemia that is alleviated by pyridoxine (vitamin B-6) treatment.
http://purl.obolibrary.org/obo/HP_0005526	Lymphoid leukemia	http://purl.obolibrary.org/obo/HP_0001909	Leukemia		A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias.
http://purl.obolibrary.org/obo/HP_0005527	Reduced kininogen activity	http://purl.obolibrary.org/obo/HP_0005559	Abnormal kinin-kallikrein system component activity		Amount or activity of kininogen is below the lower limit of normal. Kininogen functions as a cofactor in the contact phase of the intrinsic blood coagulation cascade.
http://purl.obolibrary.org/obo/HP_0005528	Bone marrow hypocellularity	http://purl.obolibrary.org/obo/HP_0012145	Abnormality of multiple cell lineages in the bone marrow		A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.
http://purl.obolibrary.org/obo/HP_0005531	Biphenotypic acute leukemia	http://purl.obolibrary.org/obo/HP_0002488	Acute leukemia		A type of actue leukemia with features characteristic of both the myeloid and lymphoid lineages. These leukemias are for this reason are designated mixed-lineage, hybrid or biphenotypic acute leukemias.
http://purl.obolibrary.org/obo/HP_0005534	Transient myeloproliferative syndrome	http://purl.obolibrary.org/obo/HP_0005547	Myeloproliferative disorder		A unique clonal neoplastic disorder that is linked to trisomy 21, is restricted to neonatal period, and spontaneously regresses. It often has characteristics of megakaryocytic lineage and is associated with GATA1 mutations in myeloblasts.
http://purl.obolibrary.org/obo/HP_0005535	Exercise-induced hemolysis	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		A form of hemolytic anemia that can be triggered by exertion.
http://purl.obolibrary.org/obo/HP_0005537	Decreased mean platelet volume	http://purl.obolibrary.org/obo/HP_0011876	Abnormal platelet volume		Average platelet volume below the lower limit of the normal reference interval.
http://purl.obolibrary.org/obo/HP_0005539	T cell chronic lymphocytic lymphoma/leukemia	http://purl.obolibrary.org/obo/HP_0005526	Lymphoid leukemia		A form of lymphoid leukemia or lymphoma in which too many T-cell lymphoblasts are found in the blood, bone marrow, and tissues. Leukemia or lymphoma classification depends on which feature is more prominent.
http://purl.obolibrary.org/obo/HP_0005542	Prolonged whole-blood clotting time	http://purl.obolibrary.org/obo/HP_0001928	Abnormality of coagulation		An abnormal prolongation (delay) in the time required by whole blood to produce a visible clot.
http://purl.obolibrary.org/obo/HP_0005543	Reduced protein C activity	http://purl.obolibrary.org/obo/HP_0030780	Abnormality of the protein C anticoagulant pathway		An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein C. Protein C is activated to protein Ca by thrombin bound to thrombomodulin. Activated protein C degrades factors VIIIa and Va.
http://purl.obolibrary.org/obo/HP_0005547	Myeloproliferative disorder	http://purl.obolibrary.org/obo/HP_0001909	Leukemia		Proliferation (excess production) of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential.
http://purl.obolibrary.org/obo/HP_0005548	Megakaryocytopenia	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		A reduced count of megakaryocytes.
http://purl.obolibrary.org/obo/HP_0005550	Chronic lymphatic leukemia	http://purl.obolibrary.org/obo/HP_0005558	Chronic leukemia		A chronic lymphocytic/lymphatic/lymphoblastic leukemia (CLL) is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid organs) of morphologically mature but immunologically dysfunctional lymphocytes. A CLL is always a B-cell lymphocytic leukemia as there are no reports of cases of T-cell lymphocytic leukemias.
http://purl.obolibrary.org/obo/HP_0005556	Abnormality of the metopic suture	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		The frontal suture divides the two halves of the frontal bone of the skull in infants and children and generally undergoes fusion by the age of six. A persistent frontal suture is referred to as a "metopic suture".
http://purl.obolibrary.org/obo/HP_0005558	Chronic leukemia	http://purl.obolibrary.org/obo/HP_0001909	Leukemia		A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia.
http://purl.obolibrary.org/obo/HP_0005559	Abnormal kinin-kallikrein system component activity	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The activity or concentration of a component of the kinin-kallikrein system is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0005560	Imbalanced hemoglobin synthesis	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia.
http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		An anomaly of the form or number of cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0005562	Multiple renal cysts	http://purl.obolibrary.org/obo/HP_0000107	Renal cyst		The presence of many cysts in the kidney.
http://purl.obolibrary.org/obo/HP_0005563	Decreased numbers of nephrons	http://purl.obolibrary.org/obo/HP_0012575	Abnormal nephron morphology		A reduction in the count of nephrons per kidney.
http://purl.obolibrary.org/obo/HP_0005564	Absence of renal corticomedullary differentiation	http://purl.obolibrary.org/obo/HP_0005932	Abnormal renal corticomedullary differentiation		A lack of differentiation between renal cortex and medulla on diagnostic imaging.
http://purl.obolibrary.org/obo/HP_0005565	Reduced renal corticomedullary differentiation	http://purl.obolibrary.org/obo/HP_0005932	Abnormal renal corticomedullary differentiation		Reduced differentiation between renal cortex and medulla on diagnostic imaging.
http://purl.obolibrary.org/obo/HP_0005567	Renal magnesium wasting	http://purl.obolibrary.org/obo/HP_0012607	Abnormal urine magnesium concentration		High urine magnesium in the presence of hypomagnesemia.
http://purl.obolibrary.org/obo/HP_0005574	Non-acidotic proximal tubulopathy	http://purl.obolibrary.org/obo/HP_0000114	Proximal tubulopathy		A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption without bicarbonate loss.
http://purl.obolibrary.org/obo/HP_0005575	Hemolytic-uremic syndrome	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		A thrombotic microangiopathy with presence of non-immune, intravascular hemolytic anemia, thrombocytopenia and acute kidney injury. A vicious cycle of complement activation, endothelial cell damage, platelet activation, and thrombosis is the hallmark of the disease.
http://purl.obolibrary.org/obo/HP_0005576	Tubulointerstitial fibrosis	http://purl.obolibrary.org/obo/HP_0001969	Abnormal tubulointerstitial morphology		A progressive detrimental connective tissue deposition (fibrosis) on the kidney parenchyma involving the tubules and interstitial tissue of the kidney. Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IF/TA) as the final common pathway. However, IF and TA are separable, as shown by the profound TA in renal artery stenosis, which characteristically has little or no fibrosis (or inflammation). For new annotations it is preferable to annotate to the specific HPO terms for Renal interstitial fibrosis and/or Renal tubular atrophy.
http://purl.obolibrary.org/obo/HP_0005579	Impaired renal tubular reabsorption of chloride	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Any impairment of reabsorption of chloride by the kidney.
http://purl.obolibrary.org/obo/HP_0005580	Duplication of renal pelvis	http://purl.obolibrary.org/obo/HP_0010944	Abnormal renal pelvis morphology		A duplication of the renal pelvis.
http://purl.obolibrary.org/obo/HP_0005583	Tubular basement membrane disintegration	http://purl.obolibrary.org/obo/HP_0020131	Abnormal tubular basement membrane morphology		DIsruption and breaking up of the basement membrane of the tubules of the kidney.
http://purl.obolibrary.org/obo/HP_0005584	Renal cell carcinoma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule.
http://purl.obolibrary.org/obo/HP_0005588	Patchy palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		A focal type of palmoplantar keratoderma in which only certain areas of the palms and soles are affected.
http://purl.obolibrary.org/obo/HP_0005592	Giant melanosomes in melanocytes	http://purl.obolibrary.org/obo/HP_0011125	Abnormal dermal melanosome morphology		The presence of large spherical melanosomes (1 to 6 micrometer in diameter) in the cytoplasm of melanocytes.
http://purl.obolibrary.org/obo/HP_0005597	Congenital alopecia totalis	http://purl.obolibrary.org/obo/HP_0007418	Alopecia totalis		Loss of all scalp hair with congenital onset.
http://purl.obolibrary.org/obo/HP_0005598	Facial telangiectasia in butterfly midface distribution	http://purl.obolibrary.org/obo/HP_0007380	Facial telangiectasia		Telangiectases (small dilated blood vessels) located near the surface of the skin in a butterfly midface distribution.
http://purl.obolibrary.org/obo/HP_0005600	Congenital giant melanocytic nevus	http://purl.obolibrary.org/obo/HP_0000995	Melanocytic nevus		The giant congenital nevus is greater than 8 cm in size, pigmented and often hairy. A giant congenital nevus is smaller in infants and children, but it usually continues to grow with the child.
http://purl.obolibrary.org/obo/HP_0005605	Large cafe-au-lait macules with irregular margins	http://purl.obolibrary.org/obo/HP_0001034	Hypermelanotic macule		Large hypermelanotic macules with jagged borders.
http://purl.obolibrary.org/obo/HP_0005608	Bilobate gallbladder	http://purl.obolibrary.org/obo/HP_0034504	Septate gallbladder		The presence of a bilobed gallbladder, related to a duplication of the gallbladder primordium.
http://purl.obolibrary.org/obo/HP_0005620	Hypermobility of interphalangeal joints	http://purl.obolibrary.org/obo/HP_0430046	Small joint hypermobility		The ability of the interphalangeal joints to move beyond their normal range of motion.
http://purl.obolibrary.org/obo/HP_0005621	Trapezoidal vertebral body	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		An anomalous trapezoidal appearance of a vertebral body. A trapezoid is a four-sided shape that has two sides that are parallel and two sides that are not parallel. In this case, the two lateral sides of the vertebra are parallel, and the top and the bottom are slanted with respect to each other such that the vertebra is shorter in the front or back than on the other side.
http://purl.obolibrary.org/obo/HP_0005622	Broad long bones	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		Increased cross-section (diameter) of the long bones. Note that widening may primarily affect specific regions of long bones (e.g., diaphysis or metaphysis), but this should be coded separately.
http://purl.obolibrary.org/obo/HP_0005623	Absent ossification of calvaria	http://purl.obolibrary.org/obo/HP_0005474	Decreased calvarial ossification		Acalvaria is an extremely rare congenital malformation characterized by an absence of flat bones of skull, dura mater, and associated muscles in the presence of normal cranial contents and facial bones.
http://purl.obolibrary.org/obo/HP_0005625	Osteoporosis of vertebrae	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		Osteoporosis affecting predominantly the vertebrae.
http://purl.obolibrary.org/obo/HP_0005626	Posterior fusion of lumbosacral vertebrae	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		Bony fusion of the posterior part of the L5 vertebral body with the sacrum.
http://purl.obolibrary.org/obo/HP_0005627	Type D brachydactyly	http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly		This type of brachydactyly is characterized by short and broad terminal phalanges of the thumbs and big toes.
http://purl.obolibrary.org/obo/HP_0005639	Hyperextensible hand joints	http://purl.obolibrary.org/obo/HP_0430046	Small joint hypermobility		The ability of the joints of the hand to move beyond their normal range of motion.
http://purl.obolibrary.org/obo/HP_0005643	Short 3rd toe	http://purl.obolibrary.org/obo/HP_0001831	Short toe		Underdevelopment (hypoplasia) of the third toe.
http://purl.obolibrary.org/obo/HP_0005645	Intervertebral disk calcification	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		The presence of abnormal calcium deposition of the intervertebral disk.
http://purl.obolibrary.org/obo/HP_0005648	Bilateral ulnar hypoplasia	http://purl.obolibrary.org/obo/HP_0003022	Hypoplasia of the ulna		Underdevelopment of the ulna on both sides.
http://purl.obolibrary.org/obo/HP_0005650	2-5 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the second to the fifth fingers that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0005652	Cortical sclerosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Sclerosis (abnormal hardening) of cortical bone, characterized by increased radiodensity.
http://purl.obolibrary.org/obo/HP_0005653	Moderate generalized osteoporosis	http://purl.obolibrary.org/obo/HP_0040160	Generalized osteoporosis		Moderate osteoporosis.
http://purl.obolibrary.org/obo/HP_0005655	Multiple digital exostoses	http://purl.obolibrary.org/obo/HP_0002762	Multiple exostoses		Multiple exostoses originating in the fingers and toes.
http://purl.obolibrary.org/obo/HP_0005661	Salmonella osteomyelitis	http://purl.obolibrary.org/obo/HP_0002754	Osteomyelitis		Osteomyelitis caused by infection with the bacteria, salmonella.
http://purl.obolibrary.org/obo/HP_0005665	Massively thickened long bone cortices	http://purl.obolibrary.org/obo/HP_0000935	Thickened cortex of long bones		Extreme thickening of the cortex of long bones.
http://purl.obolibrary.org/obo/HP_0005667	Os odontoideum	http://purl.obolibrary.org/obo/HP_0003310	Abnormal odontoid process morphology		Separation of the odontoid process from the body of the axis.
http://purl.obolibrary.org/obo/HP_0005671	Bilateral intracerebral calcifications	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		Deposition of calcium salts on both sides of the cerebrum.
http://purl.obolibrary.org/obo/HP_0005679	Dupuytren contracture	http://purl.obolibrary.org/obo/HP_0009473	Joint contracture of the hand		An abnormality of the hand resulting from contracture of the palmar fascia with a fixed flexion deformity of the metacarpophalangeal (MCP) joints and the proximal interphalangeal (PIP) joints.
http://purl.obolibrary.org/obo/HP_0005680	Tongue-like lumbar vertebral deformities	http://purl.obolibrary.org/obo/HP_0008430	Anterior beaking of lumbar vertebrae		A tongue-like protusion from the anterior aspect of lumbar vertebral bodies.
http://purl.obolibrary.org/obo/HP_0005684	Distal arthrogryposis	http://purl.obolibrary.org/obo/HP_0002803	Congenital contracture		An inherited primary limb malformation disorder characterized by congenital contractures of two or more different body areas and without primary neurologic and/or muscle disease that affects limb function.
http://purl.obolibrary.org/obo/HP_0005686	Patchy osteosclerosis	http://purl.obolibrary.org/obo/HP_0010658	Patchy changes of bone mineral density		Patchy (irregular) increase in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0005696	Postaxial polydactyly type A	http://purl.obolibrary.org/obo/HP_0001162	Postaxial hand polydactyly		Supernumerary digits located at the ulnar side of the hand with a complete extra finger and extra metacarpal.
http://purl.obolibrary.org/obo/HP_0005707	Bilateral triphalangeal thumbs	http://purl.obolibrary.org/obo/HP_0001199	Triphalangeal thumb		A bilateral form of triphalangeal thumb.
http://purl.obolibrary.org/obo/HP_0005720	Shortening of all metacarpals	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		Abnormal reduction in length of all metacarpal bones.
http://purl.obolibrary.org/obo/HP_0005722	Hyperextensible thumb	http://purl.obolibrary.org/obo/HP_0005639	Hyperextensible hand joints		The ability of the thumb joints to move beyond their normal range of motion.
http://purl.obolibrary.org/obo/HP_0005725	Nonopposable triphalangeal thumb	http://purl.obolibrary.org/obo/HP_0001199	Triphalangeal thumb		A form of triphalangeal thumb that cannot be placed opposite the fingers of the same hand.
http://purl.obolibrary.org/obo/HP_0005733	Spinal stenosis with reduced interpedicular distance	http://purl.obolibrary.org/obo/HP_0003416	Spinal canal stenosis		An abnormal narrowing of the spinal canal related to a reduction in the interpedicular distance (i.e., the distance measured between the pedicles on frontal [coronal] imaging).
http://purl.obolibrary.org/obo/HP_0005736	Short tibia	http://purl.obolibrary.org/obo/HP_0005772	Aplasia/Hypoplasia of the tibia		Underdevelopment (reduced size) of the tibia.
http://purl.obolibrary.org/obo/HP_0005739	Posterior subluxation of radial head	http://purl.obolibrary.org/obo/HP_0003048	Radial head subluxation		Partial dislocation of the head of the radius in the posterior direction.
http://purl.obolibrary.org/obo/HP_0005743	Avascular necrosis of the capital femoral epiphysis	http://purl.obolibrary.org/obo/HP_0100323	Juvenile aseptic necrosis		Avascular necrosis of the proximal epiphysis of the femur occurring in growing children and caused by an interruption of the blood supply to the head of the femur close to the hip joint. The necrosis is characteristically associated with flattening of the femoral head, for which reason the term coxa plana has been used to refer to this feature in the medical literature.
http://purl.obolibrary.org/obo/HP_0005746	Osteosclerosis of the base of the skull	http://purl.obolibrary.org/obo/HP_0005464	Craniofacial osteosclerosis		An increase in bone density affecting the basicranium (base of the skull).
http://purl.obolibrary.org/obo/HP_0005756	Neonatal epiphyseal stippling	http://purl.obolibrary.org/obo/HP_0010655	Epiphyseal stippling		The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses during the neonatal period.
http://purl.obolibrary.org/obo/HP_0005758	Basilar impression	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		Abnormal elevation of the floor of the posterior fossa including occipital condyles and foramen magnum.
http://purl.obolibrary.org/obo/HP_0005759	Small flat posterior fossa	http://purl.obolibrary.org/obo/HP_0040011	Flat posterior fossa		An abnormally small and flat configuration of the posterior cranial fossa.
http://purl.obolibrary.org/obo/HP_0005768	2-4 toe cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010621	Cutaneous syndactyly of toes		A soft tissue continuity in the anteroposterior axis between the toes 2, 3, and 4.
http://purl.obolibrary.org/obo/HP_0005769	Fifth finger distal phalanx clinodactyly	http://purl.obolibrary.org/obo/HP_0004225	Abnormality of the distal phalanx of the 5th finger		Bending or curvature of the distal phalanx of little finger in the radial direction (i.e., towards the 4th finger).
http://purl.obolibrary.org/obo/HP_0005772	Aplasia/Hypoplasia of the tibia	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		Absence or underdevelopment of the tibia.
http://purl.obolibrary.org/obo/HP_0005773	Short forearm	http://purl.obolibrary.org/obo/HP_0009821	Forearm undergrowth		Underdevelopment of both forearm bones, the ulna and the radius, resulting in a shortened forearm.
http://purl.obolibrary.org/obo/HP_0005780	Absent fourth finger distal interphalangeal crease	http://purl.obolibrary.org/obo/HP_0001032	Absent distal interphalangeal creases		Absence of the distal interphalangeal flexion creases of the fourth finger.
http://purl.obolibrary.org/obo/HP_0005787	Lumbar platyspondyly	http://purl.obolibrary.org/obo/HP_0000926	Platyspondyly		A flattened vertebral body shape with reduced distance between the vertebral endplates affecting the lumbar spine.
http://purl.obolibrary.org/obo/HP_0005789	Generalized osteosclerosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		An abnormal increase of bone mineral density with generalized involvement of the skeleton.
http://purl.obolibrary.org/obo/HP_0005791	Cortical thickening of long bone diaphyses	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		Abnormal thickening of the cortex of the diaphyseal region of long bones.
http://purl.obolibrary.org/obo/HP_0005792	Short humerus	http://purl.obolibrary.org/obo/HP_0006507	Aplasia/hypoplasia of the humerus		Underdevelopment of the humerus.
http://purl.obolibrary.org/obo/HP_0005793	Shortening of all distal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0001857	Short distal phalanx of toe		Abnormally short distal phalanx of toe of all toes.
http://purl.obolibrary.org/obo/HP_0005798	Posterior radial head dislocation	http://purl.obolibrary.org/obo/HP_0003083	Dislocated radial head		A dislocation of the head of the radius from its socket in the elbow joint in an posterior direction.
http://purl.obolibrary.org/obo/HP_0005817	Postaxial polysyndactyly of foot	http://purl.obolibrary.org/obo/HP_0001830	Postaxial foot polydactyly		Combined syndactyly and polydactyly of the foot on the lateral side (i.e., on the side of the little toe).
http://purl.obolibrary.org/obo/HP_0005819	Short middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0009843	Aplasia/Hypoplasia of the middle phalanges of the hand		Short (hypoplastic) middle phalanx of finger, affecting one or more fingers.
http://purl.obolibrary.org/obo/HP_0005824	Clinodactyly of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010326	Deviation of the 2nd toe		Bending or curvature of a second toe in the tibial direction (i.e., towards the big toe).
http://purl.obolibrary.org/obo/HP_0005830	Flexion contracture of toe	http://purl.obolibrary.org/obo/HP_0034675	Toe joint contracture		One or more bent (flexed) toe joints that cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0005844	Rounded middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		An abnormally round shape of the middle phalanx of the finger.
http://purl.obolibrary.org/obo/HP_0005849	Diffuse cerebral calcification	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		Generalized deposition of calcium salts within the cerebrum.
http://purl.obolibrary.org/obo/HP_0005855	Multiple prenatal fractures	http://purl.obolibrary.org/obo/HP_0002659	Increased susceptibility to fractures		The presence of bone fractures in the prenatal period that are diagnosed at birth or before.
http://purl.obolibrary.org/obo/HP_0005856	Ulnar radial head dislocation	http://purl.obolibrary.org/obo/HP_0003083	Dislocated radial head		A dislocation of the head of the radius from its socket in the elbow joint in an ulnar direction.
http://purl.obolibrary.org/obo/HP_0005863	Type E brachydactyly	http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly		In type E brachydactyly, shortening of the fingers is mainly in the metacarpals and metatarsals.
http://purl.obolibrary.org/obo/HP_0005864	Pseudoarthrosis	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		A pathologic entity characterized by a developmental defect in a long bone leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or "false joint").
http://purl.obolibrary.org/obo/HP_0005866	Opposable triphalangeal thumb	http://purl.obolibrary.org/obo/HP_0001199	Triphalangeal thumb		A form of triphalangeal thumb that can be placed opposite the fingers of the same hand.
http://purl.obolibrary.org/obo/HP_0005868	Metaphyseal enchondromatosis	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		An enchondroma is a benign growth of cartilage that develops within the medullary cavity of bone. Enchondromatosis refers to the presence of multiple enchondromas, and this term refers to the presence of multiple enchondromas within the medulla of metaphyseal bone. Radiographically an enchondroma presents a an oval, linear, or pyramidal osteolytic (radiolucent) lesion with well defined margins.
http://purl.obolibrary.org/obo/HP_0005871	Metaphyseal chondrodysplasia	http://purl.obolibrary.org/obo/HP_0100255	Metaphyseal dysplasia		An abnormality of skeletal development characterized by a disturbance of the metaphysis and its histological structure with relatively normal epiphyses and vertebrae.
http://purl.obolibrary.org/obo/HP_0005872	Brachytelomesophalangy	http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly		Disproportionately short middle and distal phalanges compared to the hand/foot.
http://purl.obolibrary.org/obo/HP_0005873	Polysyndactyly of hallux	http://purl.obolibrary.org/obo/HP_0001841	Preaxial foot polydactyly		Combined syndactyly and polydactyly of the great toe.
http://purl.obolibrary.org/obo/HP_0005876	Progressive flexion contractures	http://purl.obolibrary.org/obo/HP_0001371	Flexion contracture		Progressively worsening joint contractures.
http://purl.obolibrary.org/obo/HP_0005879	Congenital finger flexion contractures	http://purl.obolibrary.org/obo/HP_0100490	Camptodactyly of finger		Multiple bent (flexed) finger joints that cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0005880	Metacarpophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0011911	Abnormal metacarpophalangeal joint morphology		Fusion of a metacarpal bone with the proximal phalanx of the finger distal to it across the corresponding metacarpophalangeal joint.
http://purl.obolibrary.org/obo/HP_0005885	Absent ossification of cervical vertebral bodies	http://purl.obolibrary.org/obo/HP_0004599	Absent or minimally ossified vertebral bodies		A lack of bone mineralization of one or more body of cervical vertebra.
http://purl.obolibrary.org/obo/HP_0005886	Aphalangy of the hands	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		Absence of a digit or of one or more phalanges of a finger.
http://purl.obolibrary.org/obo/HP_0005890	Hyperostosis cranialis interna	http://purl.obolibrary.org/obo/HP_0004437	Cranial hyperostosis		Bony overgrowth of the internal (endosteal) surface of the calvaria and the base of skull.
http://purl.obolibrary.org/obo/HP_0005891	Progressive forearm bowing	http://purl.obolibrary.org/obo/HP_0006383	Progressive bowing of long bones		Progressive bending or abnormal curvature of the forearm skeleton.
http://purl.obolibrary.org/obo/HP_0005892	Proximal tibial and fibular fusion	http://purl.obolibrary.org/obo/HP_0005929	Synostosis involving the tibia		A developmental defect characterized by the abnormal fusion of the proximal tibia and fibula.
http://purl.obolibrary.org/obo/HP_0005894	Double first metacarpals	http://purl.obolibrary.org/obo/HP_0005917	Supernumerary metacarpal bones		Duplication of the metacarpal I bones.
http://purl.obolibrary.org/obo/HP_0005897	Severe generalized osteoporosis	http://purl.obolibrary.org/obo/HP_0040160	Generalized osteoporosis		Severe degree of osteoporosis.
http://purl.obolibrary.org/obo/HP_0005900	Fifth metacarpal with ulnar notch	http://purl.obolibrary.org/obo/HP_0010013	Abnormal 5th metacarpal morphology		Presence of an angular or V -shaped indentation on the ulnar side of the fifth metacarpal bone (i.e., on the sides towards the fifth finger).
http://purl.obolibrary.org/obo/HP_0005906	Delayed pneumatization of the mastoid process	http://purl.obolibrary.org/obo/HP_0000264	Abnormal mastoid morphology		An abnormally reduced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0005910	Rhomboid or triangular shaped 5th finger middle phalanx	http://purl.obolibrary.org/obo/HP_0009182	Triangular shaped middle phalanx of the 5th finger		Rhomboid or triangular shaped 5th (little) finger middle phalanx.
http://purl.obolibrary.org/obo/HP_0005912	Biliary atresia	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Atresia of the biliary tree.
http://purl.obolibrary.org/obo/HP_0005914	Aplasia/Hypoplasia involving the metacarpal bones	http://purl.obolibrary.org/obo/HP_0005927	Aplasia/hypoplasia involving bones of the hand		Aplasia or Hypoplasia affecting the metacarpal bones.
http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Abnormalities affecting the phalanx of finger.
http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005924	Abnormal hand epiphysis morphology		Abnormality of one or all of the epiphyses of the phalanges of the hand. Note that this includes the epiphysis of the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits).
http://purl.obolibrary.org/obo/HP_0005924	Abnormal hand epiphysis morphology	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		Any abnormality of the epiphyses of the phalanges or metacarpal bones.
http://purl.obolibrary.org/obo/HP_0005926	Abnormal hand cortical bone morphology	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		An anomaly of the outer shell (cortex) of a hand bone.
http://purl.obolibrary.org/obo/HP_0005927	Aplasia/hypoplasia involving bones of the hand	http://purl.obolibrary.org/obo/HP_0006496	Aplasia/hypoplasia involving bones of the upper limbs		Absence (due to failure to form) or underdevelopment of the bones of the hand.
http://purl.obolibrary.org/obo/HP_0005932	Abnormal renal corticomedullary differentiation	http://purl.obolibrary.org/obo/HP_0100957	Abnormal renal medulla morphology		An abnormality of corticomedullary differentiation (CMD) on diagnostic imaging such as magnetic resonance imaging, computer tomography, or sonography. CMD is a difference in the visualization of cortex and medulla.
http://purl.obolibrary.org/obo/HP_0005938	Abnormal respiratory motile cilium morphology	http://purl.obolibrary.org/obo/HP_0012253	Abnormal respiratory epithelium morphology		Abnormal arrangement of the structures of the motile cilium.
http://purl.obolibrary.org/obo/HP_0005942	Desquamative interstitial pneumonitis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Diffuse filling of the distal airspaces of the lungs, the alveoli, with macrophages. Desquamative interstitial pneumonitis (DIP) is characterized additionally by thickened alveolar septa and by a sparse inflammatory infiltrate that often includes plasma cells and occasional eosinophils. The alveoli are lined by plump cuboidal pneumocytes. Lymphoid aggregates may be present.
http://purl.obolibrary.org/obo/HP_0005944	Bilateral lung agenesis	http://purl.obolibrary.org/obo/HP_0006703	Aplasia/Hypoplasia of the lungs		Bilateral lack of development of the lungs.
http://purl.obolibrary.org/obo/HP_0005945	Laryngeal obstruction	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Blockage of the upper airway at the level of the larynx often accompanied by respiratory distress.
http://purl.obolibrary.org/obo/HP_0005947	Decreased sensitivity to hypoxemia	http://purl.obolibrary.org/obo/HP_0005957	Breathing dysregulation		Reduced tendency to respond to a reduced concentration of oxygen in the blood by increasing respiration.
http://purl.obolibrary.org/obo/HP_0005948	Multiple pulmonary cysts	http://purl.obolibrary.org/obo/HP_0032445	Pulmonary cyst		The presence of multiple lung cysts.
http://purl.obolibrary.org/obo/HP_0005949	Apneic episodes in infancy	http://purl.obolibrary.org/obo/HP_0002104	Apnea		Recurrent episodes of apnea occurring during infancy.
http://purl.obolibrary.org/obo/HP_0005950	Laryngeal web	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		A membrane-like structure that extends across the laryngeal lumen close to the level of the vocal cords.
http://purl.obolibrary.org/obo/HP_0005956	Anteroposteriorly shortened larynx	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Abnormal shortening of the larynx in the anteroposterior (front to back) axis.
http://purl.obolibrary.org/obo/HP_0005959	Impaired gluconeogenesis	http://purl.obolibrary.org/obo/HP_0011014	Abnormal glucose homeostasis		An impairment of gluconeogenesis.
http://purl.obolibrary.org/obo/HP_0005961	Hypoargininemia	http://purl.obolibrary.org/obo/HP_0010909	Abnormal circulating arginine concentration		The concentration of arginine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0005964	Intermittent hypothermia	http://purl.obolibrary.org/obo/HP_0002045	Hypothermia		Episodes of reduced body temperature.
http://purl.obolibrary.org/obo/HP_0005968	Temperature instability	http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation		Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature.
http://purl.obolibrary.org/obo/HP_0005972	Respiratory acidosis	http://purl.obolibrary.org/obo/HP_0001941	Acidosis		Acidosis because of respiratory retention of carbon dioxide.
http://purl.obolibrary.org/obo/HP_0005973	Fructose intolerance	http://purl.obolibrary.org/obo/HP_0011033	Impairment of fructose metabolism		Reduced intestinal absorption of fructose. Breath testing after ingestion of fructose has been widely adopted as a standard method of identifying fructose malabsorption and intolerance. A dose of 25 g of fructose dissolved in a 10% solution is generally accepted as the appropriate dose of fructose for clinical use of H2 and CH4 breath testing. High levels of hydrogen in exhaled breath subsequent hours indicate fructose intolerance. Presence of malabsorption and reproduction of symptoms during a breath test provides the best objective evidence and symptom correlation for fructose intolerance.
http://purl.obolibrary.org/obo/HP_0005974	Episodic ketoacidosis	http://purl.obolibrary.org/obo/HP_0001993	Ketoacidosis		Intermittent episodes of ketoacidosis.
http://purl.obolibrary.org/obo/HP_0005978	Type II diabetes mellitus	http://purl.obolibrary.org/obo/HP_0000819	Diabetes mellitus		A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia.
http://purl.obolibrary.org/obo/HP_0005979	Metabolic ketoacidosis	http://purl.obolibrary.org/obo/HP_0001993	Ketoacidosis		A metabolic acidosis due to accumulation of ketone bodies generally observed in the setting of poor nutritional intake.
http://purl.obolibrary.org/obo/HP_0005982	Reduced phenylalanine hydroxylase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		A reduction in phenylalanine 4-monooxygenase level.
http://purl.obolibrary.org/obo/HP_0005987	Multinodular goiter	http://purl.obolibrary.org/obo/HP_0005994	Nodular goiter		Enlargement of the thyroid gland related to multiple nodules in the thyroid gland.
http://purl.obolibrary.org/obo/HP_0005988	Congenital muscular torticollis	http://purl.obolibrary.org/obo/HP_0011006	Abnormal morphology of the musculature of the neck		A congenital form of torticollis resulting from shortening of the sternocleidomastoid muscle and leading to a limited range of motion in both rotation and lateral bending.
http://purl.obolibrary.org/obo/HP_0005989	Redundant neck skin	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Excess skin around the neck, often lying in horizontal folds.
http://purl.obolibrary.org/obo/HP_0005990	Thyroid hypoplasia	http://purl.obolibrary.org/obo/HP_0033079	Aplasia/Hypoplasia of the thyroid gland		Developmental hypoplasia of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0005991	Limited neck flexion	http://purl.obolibrary.org/obo/HP_0005986	Limitation of neck motion		Reduced ability to lower the chin towards the chest by bending the neck.
http://purl.obolibrary.org/obo/HP_0005994	Nodular goiter	http://purl.obolibrary.org/obo/HP_0000853	Goiter		Enlargement of the thyroid gland related to one or more nodules in the thyroid gland.
http://purl.obolibrary.org/obo/HP_0005995	Decreased adipose tissue around neck	http://purl.obolibrary.org/obo/HP_0003758	Reduced subcutaneous adipose tissue		Reduced amount of adipose tissue in the region of the neck.
http://purl.obolibrary.org/obo/HP_0005999	Ureteral atresia	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		A developmental defect defined by the failure of the formation of the lumen (tube) of the ureter.
http://purl.obolibrary.org/obo/HP_0006009	Broad phalanx	http://purl.obolibrary.org/obo/HP_0005622	Broad long bones		Increased side-to-side width of one or more phalanges of the fingers or toes.
http://purl.obolibrary.org/obo/HP_0006011	Cuboidal metacarpal	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		Severely shortened metacarpal with a cuboidal appearance.
http://purl.obolibrary.org/obo/HP_0006016	Delayed phalangeal epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0002663	Delayed epiphyseal ossification		Delay in the process of formation and maturation of the epiphysis of one or more phalanx.
http://purl.obolibrary.org/obo/HP_0006028	Metaphyseal cupping of metacarpals	http://purl.obolibrary.org/obo/HP_0003021	Metaphyseal cupping		Metaphyseal cupping affecting the metacarpal bones.
http://purl.obolibrary.org/obo/HP_0006042	Y-shaped metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Y-shaped metacarpals are the result of a partial fusion of two metacarpal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metacarpals may be seen in combination with polydactyly.
http://purl.obolibrary.org/obo/HP_0006048	Distal widening of metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Abnormal increase in width of the distal region of the metacarpal bones.
http://purl.obolibrary.org/obo/HP_0006059	Cone-shaped metacarpal epiphyses	http://purl.obolibrary.org/obo/HP_0010579	Cone-shaped epiphysis		A cone-shaped appearance of the epiphyses of the metacarpal bones, producing a 'ball-in-a-socket' appearance. This epiphyses are located at the distal ends of the metacarpal bones.
http://purl.obolibrary.org/obo/HP_0006067	Multiple carpal ossification centers	http://purl.obolibrary.org/obo/HP_0006257	Abnormality of carpal bone ossification		A delay in the process of formation and maturation of the epiphysis of one or more long bones.
http://purl.obolibrary.org/obo/HP_0006070	Metacarpophalangeal joint contracture	http://purl.obolibrary.org/obo/HP_0011911	Abnormal metacarpophalangeal joint morphology		A chronic loss of joint motion in metacarpophalangeal joints due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.
http://purl.obolibrary.org/obo/HP_0006077	Absent proximal finger flexion creases	http://purl.obolibrary.org/obo/HP_0006109	Absent phalangeal crease		Absence of the proximal interphalangeal flexion creases of the fingers.
http://purl.obolibrary.org/obo/HP_0006092	Malaligned carpal bone	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		Malalignement of carpal bone angles either with respect to each other, to the corresponding metacarpals or with respect to the wrist (radius and ulna).
http://purl.obolibrary.org/obo/HP_0006097	3-4 finger osseus syndactyly	http://purl.obolibrary.org/obo/HP_0010492	Osseous finger syndactyly		Fusion of the third (middle) and fourth (ring) finger, involving soft parts and including fusion of individual finger bones.
http://purl.obolibrary.org/obo/HP_0006099	Metacarpophalangeal joint hyperextensibility	http://purl.obolibrary.org/obo/HP_0011911	Abnormal metacarpophalangeal joint morphology		Increased mobility of one ore more metacarpophalangeal joint.
http://purl.obolibrary.org/obo/HP_0006107	Fingerpad telangiectases	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		Telangiectasia (small dilated blood vessels) located in the fingerpads at the tips of the fingers.
http://purl.obolibrary.org/obo/HP_0006108	Tapered metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Metacarpal that becomes thinner toward the distal end.
http://purl.obolibrary.org/obo/HP_0006110	Shortening of all middle phalanges of the fingers	http://purl.obolibrary.org/obo/HP_0005819	Short middle phalanx of finger		Short, hypoplastic middle phalanx of finger, affecting all fingers.
http://purl.obolibrary.org/obo/HP_0006114	Multiple palmar creases	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		The presence of multiple creases on the palm of the hand (more than the normal three major creases (distal transverse crease, proximal transverse crease, and thenar crease).
http://purl.obolibrary.org/obo/HP_0006118	Shortening of all distal phalanges of the fingers	http://purl.obolibrary.org/obo/HP_0009882	Short distal phalanx of finger		Hypoplasia of all of the distal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0006121	Acral ulceration	http://purl.obolibrary.org/obo/HP_0031917	Digital ulcer		A type of digital ulcer that manifests as an open sore on the surface of the skin at the tip of a finger or toe.
http://purl.obolibrary.org/obo/HP_0006127	Long proximal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		Increased length of the proximal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0006129	Drumstick terminal phalanges	http://purl.obolibrary.org/obo/HP_0009832	Abnormal distal phalanx morphology of finger		Rounding and broadening of the tufts of the distal phalanges.
http://purl.obolibrary.org/obo/HP_0006134	Enlarged metacarpal epiphyses	http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology		Abnormally large size of one or more growth plates (epiphyses) of the metacarpal bones (i.e., the tubular bones of the hand between the carpus and the phalanges).
http://purl.obolibrary.org/obo/HP_0006140	Premature fusion of phalangeal epiphyses	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Fusion of the epiphysis and metaphysis of one or more phalanges prior to the normal age or stage of growth.
http://purl.obolibrary.org/obo/HP_0006144	Shortening of all proximal phalanges of the fingers	http://purl.obolibrary.org/obo/HP_0010241	Short proximal phalanx of finger		Congenital hypoplasia of proximal phalanx of finger or all fingers.
http://purl.obolibrary.org/obo/HP_0006145	Central Y-shaped metacarpal	http://purl.obolibrary.org/obo/HP_0006042	Y-shaped metacarpals		A central Y-shaped metacarpal is the result of a partial fusion of two central metacarpals (i.e., metacarpals 2-4) of the hand, with the two arms of the Y pointing in the distal direction. Central Y-shaped metacarpals may be seen as a result of a central polydactyly with partial fusion of the duplicated metacarpal.
http://purl.obolibrary.org/obo/HP_0006146	Broad metacarpal epiphyses	http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology		Increased side-to-side width of the metacarpal epiphyses.
http://purl.obolibrary.org/obo/HP_0006150	Swan neck-like deformities of the fingers	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		A swan neck deformity describes a finger with a hyperextended PIP joint and a flexed DIP joint. The most common cause for a swan neck-like deformity is a disruption of the end of the extensor tendon. Conditions that loosen the PIP joint and allow it to hyperextend, for example conditions that weaken the volar plate, can produce a swan neck deformity of the finger. One example is rheumatoid arthritis. Another cause are conditions that tighten up the small (intrinsic) muscles of the hand and fingers, for example hand trauma or nerve disorders, such as cerebral palsy, Parkinson's disease, or stroke.
http://purl.obolibrary.org/obo/HP_0006152	Proximal finger symphalangism	http://purl.obolibrary.org/obo/HP_0100264	Proximal symphalangism		The term proximal symphalangism refers to a bony fusion of the middle and proximal phalanges of the digits of the hand, in other words the proximal interphalangeal joint (PIJ) is missing which can be seen either on x-rays or as an absence of the proximal interphalangeal finger creases.
http://purl.obolibrary.org/obo/HP_0006155	Long phalanx of finger	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Increased length of multiple or a single phalanx of finger.
http://purl.obolibrary.org/obo/HP_0006156	Ulnar deviation of thumb	http://purl.obolibrary.org/obo/HP_0009465	Ulnar deviation of finger		Bending or curvature of a thumb towards the ulnar side (towards the ring finger).
http://purl.obolibrary.org/obo/HP_0006159	Mesoaxial hand polydactyly	http://purl.obolibrary.org/obo/HP_0100260	Mesoaxial polydactyly		The presence of a supernumerary finger (not a thumb) involving the third or fourth metacarpal with associated osseous syndactyly.
http://purl.obolibrary.org/obo/HP_0006160	Irregular metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Irregular morphology of one or more metacarpal bones.
http://purl.obolibrary.org/obo/HP_0006170	Chess-pawn distal phalanges	http://purl.obolibrary.org/obo/HP_0009832	Abnormal distal phalanx morphology of finger		A morphological abnormality of distal phalanges such that they have the appearance of chess pawns.
http://purl.obolibrary.org/obo/HP_0006174	Metacarpal diaphyseal endosteal sclerosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Increase in bone density in the diaphyseal (shaft) region of a metacarpal bone.
http://purl.obolibrary.org/obo/HP_0006184	Decreased palmar creases	http://purl.obolibrary.org/obo/HP_0010488	Aplasia/Hypoplasia of the palmar creases		Poorly defined or shallow palmar creases.
http://purl.obolibrary.org/obo/HP_0006191	Deep palmar crease	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		Excessively deep creases of the palm.
http://purl.obolibrary.org/obo/HP_0006192	Tapered phalanx of finger	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Phalanges of the fingers becoming thinner toward the distal end.
http://purl.obolibrary.org/obo/HP_0006193	Thimble-shaped middle phalanges of hand	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		The middle phalanx of finger resembles a thimble, a small metal cap to protect the finger while sewing that has a broad (proximal) base and narrower top, whereby both base and top are flat.
http://purl.obolibrary.org/obo/HP_0006205	Irregular phalanges	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Alteration of the normally smooth radiographic contour of phalanges producing an irregular appearance.
http://purl.obolibrary.org/obo/HP_0006206	Hypersegmentation of proximal phalanx of second finger	http://purl.obolibrary.org/obo/HP_0009544	Abnormality of the proximal phalanx of the 2nd finger		Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0006208	Metaphyseal cupping of proximal phalanges	http://purl.obolibrary.org/obo/HP_0003021	Metaphyseal cupping		Metaphyseal cupping affecting the proximal phalanges.
http://purl.obolibrary.org/obo/HP_0006216	Single interphalangeal crease of fifth finger	http://purl.obolibrary.org/obo/HP_0006109	Absent phalangeal crease		Presence of only one (instead of two, as normal) interphalangeal crease of the fifth finger.
http://purl.obolibrary.org/obo/HP_0006224	Tapering pointed ends of distal finger phalanges	http://purl.obolibrary.org/obo/HP_0009884	Tapered distal phalanges of finger		A reduction in diameter of the distal phalanx of finger towards the distal end such that the tip of the phalanx comes to a point (this feature can be observed on radiograms).
http://purl.obolibrary.org/obo/HP_0006234	Osteolysis involving tarsal bones	http://purl.obolibrary.org/obo/HP_0009134	Osteolysis involving bones of the feet		An increased resorption of bone matrix by osteoclasts leading to bony defects involving the tarsal bones.
http://purl.obolibrary.org/obo/HP_0006236	Slender metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Decreased width of the metacarpal bones (that is, reduced diameter).
http://purl.obolibrary.org/obo/HP_0006239	Shortening of all middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0003795	Short middle phalanx of toe		Abnormal shortening of all middle phalanges of toes.
http://purl.obolibrary.org/obo/HP_0006248	Limited wrist movement	http://purl.obolibrary.org/obo/HP_0025799	Abnormal wrist physiology		An abnormal limitation of the mobility of the wrist.
http://purl.obolibrary.org/obo/HP_0006254	Elevated circulating alpha-fetoprotein concentration	http://purl.obolibrary.org/obo/HP_0045056	Abnormal circulating alpha-fetoprotein concentration		The concentration of alpha-fetoprotein in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0006262	Aplasia/Hypoplasia of the 5th finger	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		A small/hypoplastic or absent/aplastic 5th finger.
http://purl.obolibrary.org/obo/HP_0006263	Abnormality of the epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0006264	Aplasia/Hypoplasia of the 2nd finger	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		A small/hypoplastic or absent/aplastic 2nd finger.
http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers	http://purl.obolibrary.org/obo/HP_0005927	Aplasia/hypoplasia involving bones of the hand		Small/hypoplastic or absent/aplastic fingers.
http://purl.obolibrary.org/obo/HP_0006266	Small placenta	http://purl.obolibrary.org/obo/HP_0012767	Abnormal placental size		Reduced size of the placenta.
http://purl.obolibrary.org/obo/HP_0006267	Large placenta	http://purl.obolibrary.org/obo/HP_0012767	Abnormal placental size		Increased size of the placenta.
http://purl.obolibrary.org/obo/HP_0006268	Fluctuating splenomegaly	http://purl.obolibrary.org/obo/HP_0001744	Splenomegaly		Intermittently increased size of the spleen.
http://purl.obolibrary.org/obo/HP_0006270	Hypoplastic spleen	http://purl.obolibrary.org/obo/HP_0010451	Aplasia/Hypoplasia of the spleen		Underdevelopment of the spleen.
http://purl.obolibrary.org/obo/HP_0006273	Pancreatic lymphangiectasis	http://purl.obolibrary.org/obo/HP_0031842	Lymphangiectasis		The presence of lymphangiectasis in the pancreas.
http://purl.obolibrary.org/obo/HP_0006274	Reduced pancreatic beta cells	http://purl.obolibrary.org/obo/HP_0006476	Abnormality of the pancreatic islet cells		Reduced number of beta cells in the pancreatic islets of Langerhans.
http://purl.obolibrary.org/obo/HP_0006277	Pancreatic hyperplasia	http://purl.obolibrary.org/obo/HP_0012094	Abnormal pancreas size		Hyperplasia of the pancreas.
http://purl.obolibrary.org/obo/HP_0006278	Ectopic pancreatic tissue	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		The presence of pancreatic tissue outside the normal pancreas, in many cases along the foregut and proximal midgut.
http://purl.obolibrary.org/obo/HP_0006280	Chronic pancreatitis	http://purl.obolibrary.org/obo/HP_0001733	Pancreatitis		A chronic form of pancreatitis.
http://purl.obolibrary.org/obo/HP_0006282	Generalized hypoplasia of dental enamel	http://purl.obolibrary.org/obo/HP_0006297	Enamel hypoplasia		A generalized form of developmental hypoplasia of the dental enamel.
http://purl.obolibrary.org/obo/HP_0006283	Multiple unerupted teeth	http://purl.obolibrary.org/obo/HP_0000706	Eruption failure		The presence of multiple embedded tooth germs which have failed to erupt.
http://purl.obolibrary.org/obo/HP_0006285	Enamel hypomineralization	http://purl.obolibrary.org/obo/HP_0000682	Abnormal dental enamel morphology		A decreased amount of enamel mineralization. Hypomineralized enamel has a brown discoloration and brittle aspect.
http://purl.obolibrary.org/obo/HP_0006289	Agenesis of central incisor	http://purl.obolibrary.org/obo/HP_0006485	Agenesis of incisor		Agenesis of one or more central incisors, i.e., of lower secondary incisor, lower primary incisor, upper secondary incisor, or of upper central primary incisor.
http://purl.obolibrary.org/obo/HP_0006290	Discolored lateral incisors	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		The presence of discolored lateral incisors.
http://purl.obolibrary.org/obo/HP_0006293	Agenesis of maxillary central incisor	http://purl.obolibrary.org/obo/HP_0200160	Agenesis of maxillary incisor		Agenesis of upper secondary incisor or of upper central primary incisor.
http://purl.obolibrary.org/obo/HP_0006297	Enamel hypoplasia	http://purl.obolibrary.org/obo/HP_0000685	Hypoplasia of teeth		Developmental hypoplasia of the dental enamel.
http://purl.obolibrary.org/obo/HP_0006298	Prolonged bleeding after dental extraction	http://purl.obolibrary.org/obo/HP_0011890	Prolonged bleeding following procedure		Prolonged bleeding post dental extraction sufficient to require medical intervention.
http://purl.obolibrary.org/obo/HP_0006302	Dagger-shaped pulp calcifications	http://purl.obolibrary.org/obo/HP_0003771	Pulp calcification		Dagger-shaped calcifications in the dental pulp.
http://purl.obolibrary.org/obo/HP_0006311	Generalized microdontia	http://purl.obolibrary.org/obo/HP_0000691	Microdontia		A generalized form of microdontia.
http://purl.obolibrary.org/obo/HP_0006313	Widely spaced primary teeth	http://purl.obolibrary.org/obo/HP_0006481	Abnormal primary tooth morphology		Increased space between the primary teeth. Note this phenotype should be distinguished from increased space due purely to microdontia.
http://purl.obolibrary.org/obo/HP_0006315	Solitary median maxillary central incisor	http://purl.obolibrary.org/obo/HP_0011064	Abnormal number of incisors		A single maxillary central incisor positioned in the midline with morphological symmetry of the crown and bordered by lateral incisors.
http://purl.obolibrary.org/obo/HP_0006316	Irregularly spaced teeth	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Irregular distribution of the teeth along the dental arch, i.e., and irregular spatial pattern of teeth.
http://purl.obolibrary.org/obo/HP_0006323	Premature loss of primary teeth	http://purl.obolibrary.org/obo/HP_0006480	Premature loss of teeth		Loss of the primary (also known as deciduous) teeth before the usual age.
http://purl.obolibrary.org/obo/HP_0006329	Alveolar process hypoplasia	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		Underdevelopment of the alveolar process (also known as alveolar bone).
http://purl.obolibrary.org/obo/HP_0006332	Supernumerary maxillary incisor	http://purl.obolibrary.org/obo/HP_0011069	Supernumerary tooth		The presence of a supernumerary, i.e., extra, maxillary incisor, either the primary maxillary incisor or the permanent maxillary incisor.
http://purl.obolibrary.org/obo/HP_0006333	Crowded maxillary incisors	http://purl.obolibrary.org/obo/HP_0011062	Misalignment of incisors		A type of dental misalignment with crowded central incisors, i.e., of maxillary secondary incisor, or of maxillary central primary incisor.
http://purl.obolibrary.org/obo/HP_0006335	Persistence of primary teeth	http://purl.obolibrary.org/obo/HP_0006481	Abnormal primary tooth morphology		Persistence of the primary teeth beyond the age by which they normally are shed and replaced by the permanent teeth.
http://purl.obolibrary.org/obo/HP_0006336	Short dental root	http://purl.obolibrary.org/obo/HP_0040220	Abnormal size of the dental root		Tooth root length more than 2 SD below mean, or subjectively apparently decreased tooth root length.
http://purl.obolibrary.org/obo/HP_0006337	Premature eruption of permanent teeth	http://purl.obolibrary.org/obo/HP_0006288	Advanced eruption of teeth		Premature tooth eruption of the permanent dentition.
http://purl.obolibrary.org/obo/HP_0006338	Malformation of mandibular premolar	http://purl.obolibrary.org/obo/HP_0011080	Abnormal premolar morphology		An abnormality of the morphology of secondary premolar tooth.
http://purl.obolibrary.org/obo/HP_0006339	Conical mandibular incisor	http://purl.obolibrary.org/obo/HP_0011065	Conical incisor		An abnormal conical morphology of the primary or permanent mandibular incisors.
http://purl.obolibrary.org/obo/HP_0006342	Peg-shaped maxillary lateral incisors	http://purl.obolibrary.org/obo/HP_0011065	Conical incisor		A tooth crown with its mesial and distal sides converging or tapering toward the incisal edge causing severe reduction of mesiodistal diameter
http://purl.obolibrary.org/obo/HP_0006344	Abnormal primary molar morphology	http://purl.obolibrary.org/obo/HP_0011070	Abnormal molar morphology		An abnormality of morphology of primary molar.
http://purl.obolibrary.org/obo/HP_0006346	Screwdriver-shaped incisors	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		An abnormality of morphology of the incisor tooth in which the tooth is shaped like a screwdriver blade, i.e., having a rhomboid shape.
http://purl.obolibrary.org/obo/HP_0006347	Microdontia of primary teeth	http://purl.obolibrary.org/obo/HP_0006481	Abnormal primary tooth morphology		Decreased size of the primary teeth.
http://purl.obolibrary.org/obo/HP_0006349	Agenesis of permanent teeth	http://purl.obolibrary.org/obo/HP_0011044	Abnormal number of permanent teeth		A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth.
http://purl.obolibrary.org/obo/HP_0006350	Pulp obliteration	http://purl.obolibrary.org/obo/HP_0006479	Abnormal dental pulp morphology		Mineralized substance filling the entire dental pulp space.
http://purl.obolibrary.org/obo/HP_0006352	Failure of eruption of permanent teeth	http://purl.obolibrary.org/obo/HP_0000706	Eruption failure		Lack of tooth eruption of the secondary dentition.
http://purl.obolibrary.org/obo/HP_0006353	Hypoplasia of the tooth germ	http://purl.obolibrary.org/obo/HP_0000685	Hypoplasia of teeth		Developmental hypoplasia of the tooth germ, i.e., of the structure that forms in odontogenesis that will develop into a tooth.
http://purl.obolibrary.org/obo/HP_0006355	Agenesis of mandibular central incisor	http://purl.obolibrary.org/obo/HP_0006289	Agenesis of central incisor		Agenesis of lower secondary incisor or lower primary incisor.
http://purl.obolibrary.org/obo/HP_0006357	Premature loss of permanent teeth	http://purl.obolibrary.org/obo/HP_0006480	Premature loss of teeth		Premature loss of the permanent teeth.
http://purl.obolibrary.org/obo/HP_0006358	Shovel-shaped maxillary central incisors	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		A tooth with a crown with marked lingual or palatal marginal ridges causing scooped lingual or palatal surfaces.
http://purl.obolibrary.org/obo/HP_0006367	Crumpled long bones	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		An crumpled radiographic appearance of the long bones, as if the long bone had been crushed together producing irregularities. This feature is the result of multiple fractures and repeated rounds of ineffective healing, as can be seen for instance in severe forms of osteogenesis imperfecta.
http://purl.obolibrary.org/obo/HP_0006369	Irregular patellae	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		An alteration of the normally relatively smooth margins of the kneecap in radiographic images leading to an irregular contour.
http://purl.obolibrary.org/obo/HP_0006370	Distal ulnar epiphyseal stippling	http://purl.obolibrary.org/obo/HP_0010600	Abnormal distal ulnar epiphysis morphology		The presence of abnormal punctate (speckled, dot-like) calcifications in the distal epiphysis of the ulna.
http://purl.obolibrary.org/obo/HP_0006371	Broad long bone diaphyses	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		Increased width of the diaphysis of long bones.
http://purl.obolibrary.org/obo/HP_0006375	Dumbbell-shaped femur	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		The femur is shortened and displays flaring (widening) of the metaphyses.
http://purl.obolibrary.org/obo/HP_0006380	Knee flexion contracture	http://purl.obolibrary.org/obo/HP_0034671	Knee contracture		A type of knee joint contracture in which the knee is in a fixed bent (flexed) configuration such that it cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0006381	Rudimentary fibula	http://purl.obolibrary.org/obo/HP_0003038	Fibular hypoplasia		Absent or nearly absent fibula. (Does not include aplastic)
http://purl.obolibrary.org/obo/HP_0006383	Progressive bowing of long bones	http://purl.obolibrary.org/obo/HP_0006487	Bowing of the long bones		Progressive bending or abnormal curvature of a long bone.
http://purl.obolibrary.org/obo/HP_0006384	Club-shaped distal femur	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		An abnormal conformation of the femur that becomes gradually enlarged towards the distal end. This feature affects the distal femoral metaphysis and epiphysis.
http://purl.obolibrary.org/obo/HP_0006385	Short lower limbs	http://purl.obolibrary.org/obo/HP_0009816	Lower limb undergrowth		Shortening of the legs related to developmental hypoplasia of the bones of the leg.
http://purl.obolibrary.org/obo/HP_0006386	Hypoplastic distal radial epiphyses	http://purl.obolibrary.org/obo/HP_0010597	Abnormality of the distal radial epiphysis		Underdevelopment of the distal epiphysis of the radius.
http://purl.obolibrary.org/obo/HP_0006387	Wide distal femoral metaphysis	http://purl.obolibrary.org/obo/HP_0006417	Wide femoral metaphysis		Increased width of the distal part of the shaft (metaphysis) of the femur.
http://purl.obolibrary.org/obo/HP_0006389	Limited knee flexion	http://purl.obolibrary.org/obo/HP_0010501	Limitation of knee mobility		Reduced ability to flex (bend) the knee joint.
http://purl.obolibrary.org/obo/HP_0006390	Anterior tibial bowing	http://purl.obolibrary.org/obo/HP_0002982	Tibial bowing		An abnormal anterior bending or curvature of the tibia.
http://purl.obolibrary.org/obo/HP_0006391	Overtubulated long bones	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		Overconstriction, or narrowness of the diaphysis and metaphysis of long bones.
http://purl.obolibrary.org/obo/HP_0006394	Limited pronation/supination of forearm	http://purl.obolibrary.org/obo/HP_0002996	Limited elbow movement		A limitation of the ability to place the forearm in a position such that the palm faces anteriorly (supination) and to place the forearm in a position such that the palm faces posteriorly (pronation).
http://purl.obolibrary.org/obo/HP_0006398	Flat distal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0030289	Flattened femoral epiphysis		An abnormal flattening of the distal epiphysis of femur.
http://purl.obolibrary.org/obo/HP_0006406	Club-shaped proximal femur	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		An abnormal conformation of the femur that becomes gradually enlarged towards the proximal end. This feature affects the proximal femoral metaphysis and epiphysis.
http://purl.obolibrary.org/obo/HP_0006407	Irregular distal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0010590	Abnormality of the distal femoral epiphysis		Anomaly of the contour of the Distal epiphysis of femur such that its normally smooth appearance is irregular.
http://purl.obolibrary.org/obo/HP_0006409	Progressive leg bowing	http://purl.obolibrary.org/obo/HP_0006383	Progressive bowing of long bones		Progressive bending or abnormal curvature of the leg.
http://purl.obolibrary.org/obo/HP_0006414	Distal tibial bowing	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		A bending or abnormal curvature of the distal portion of the tibia.
http://purl.obolibrary.org/obo/HP_0006415	Cortically dense long tubular bones	http://purl.obolibrary.org/obo/HP_0000935	Thickened cortex of long bones		Increased density of the compact bone of long bone.
http://purl.obolibrary.org/obo/HP_0006424	Elongated radius	http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius		Increased length of the radius.
http://purl.obolibrary.org/obo/HP_0006429	Broad femoral neck	http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology		An abnormally wide femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).
http://purl.obolibrary.org/obo/HP_0006431	Abnormal proximal femoral metaphysis morphology	http://purl.obolibrary.org/obo/HP_0006489	Abnormal femoral metaphysis morphology		An anomaly of the metaphysis of the proximal femur (close to the hip).
http://purl.obolibrary.org/obo/HP_0006433	Radial ray deficiency	http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius		Radial dysplasia, also known as radial longitudinal deficiency, includes radial clubhand and is a disfiguring, and potentially disabling, congenital limb anomaly. The entire upper limb may be involved, although the defect is most evident in the forearm and hand. Affected children suffer a variable degree of hypoplasia or absence of the preaxial skeleton and soft tissues, in particular the thumb, radius, and dorsoradial soft tissues. The hand is usually radially deviated and subluxated off the distal aspect of the ulna, the ulna may be shortened and have a bow-shaped deformity, and there is no true wrist (radiocarpal) joint in Bayne2 type-III and IV radial dysplasia.
http://purl.obolibrary.org/obo/HP_0006434	Hypoplasia of proximal radius	http://purl.obolibrary.org/obo/HP_0002984	Hypoplasia of the radius		Proximal radial shortening owing to a congenital defect of development.
http://purl.obolibrary.org/obo/HP_0006438	Enlargement of the distal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0010590	Abnormality of the distal femoral epiphysis		An abnormal enlargement of the distal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0006439	Radioulnar dislocation	http://purl.obolibrary.org/obo/HP_0003059	Abnormality of the radioulnar joints		A dislocation is a separation of the radius and ulna bones where they normally meet. The radioulnar joints are two locations, proximal and distal, in which the radius and ulna articulate in the forearm. Both can dislocate.
http://purl.obolibrary.org/obo/HP_0006442	Hypoplasia of proximal fibula	http://purl.obolibrary.org/obo/HP_0003038	Fibular hypoplasia		Underdevelopment or shortening of the end of the fibula (calf bone) nearest the knee.
http://purl.obolibrary.org/obo/HP_0006443	Patellar aplasia	http://purl.obolibrary.org/obo/HP_0006498	Aplasia/Hypoplasia of the patella		Absence of the patella.
http://purl.obolibrary.org/obo/HP_0006453	Lateral displacement of the femoral head	http://purl.obolibrary.org/obo/HP_0003368	Abnormal femoral head morphology		A developmental anomaly with lateral displacement of the femoral head.
http://purl.obolibrary.org/obo/HP_0006454	Delayed patellar ossification	http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification		Formation of bone in the patella later than normal.
http://purl.obolibrary.org/obo/HP_0006456	Irregular proximal tibial epiphyses	http://purl.obolibrary.org/obo/HP_0010591	Abnormality of the proximal tibial epiphysis		Anomaly of the contour of the proximal epiphysis of the tibia such that its normally smooth appearance is irregular.
http://purl.obolibrary.org/obo/HP_0006459	Dorsal subluxation of ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Partial dislocation of the ulna in the dorsal direction.
http://purl.obolibrary.org/obo/HP_0006460	Ankle hypermobility	http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology		The ankle joint can move, passively and/or actively, beyond normal limits along its physiological axes.
http://purl.obolibrary.org/obo/HP_0006461	Proximal femoral epiphysiolysis	http://purl.obolibrary.org/obo/HP_0010574	Abnormality of the epiphysis of the femoral head		Slipped capital femoral epiphysis is defined as a posterior and inferior slippage of the proximal epiphysis of the femur onto the metaphysis (femoral neck), occurring through the physeal plate during the early adolescent growth spurt.
http://purl.obolibrary.org/obo/HP_0006462	Generalized bone demineralization	http://purl.obolibrary.org/obo/HP_0004349	Reduced bone mineral density		A generalized decrease in bone mineral density.
http://purl.obolibrary.org/obo/HP_0006465	Periosteal thickening of long tubular bones	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		Thickening of the periosteum of long bone.
http://purl.obolibrary.org/obo/HP_0006467	Limited shoulder movement	http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology		A limitation of the range of movement of the shoulder joint.
http://purl.obolibrary.org/obo/HP_0006470	Thin long bone diaphyses	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		Decreased width of the diaphysis of long bones.
http://purl.obolibrary.org/obo/HP_0006473	Anterior bowing of long bones	http://purl.obolibrary.org/obo/HP_0006487	Bowing of the long bones		An abnormal anterior curvature of a long bone.
http://purl.obolibrary.org/obo/HP_0006476	Abnormality of the pancreatic islet cells	http://purl.obolibrary.org/obo/HP_0012093	Abnormality of endocrine pancreas physiology		An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin.
http://purl.obolibrary.org/obo/HP_0006480	Premature loss of teeth	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		Exfoliation of a tooth more than 2 SD earlier than the normal age for the deciduous teeth and not related to traume or neglect. Exfoliation of a permanent tooth is per se abnormal.
http://purl.obolibrary.org/obo/HP_0006483	Abnormal number of teeth	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		The presence of an altered number of of teeth.
http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		Absence (due to failure to form) or underdevelopment of the bones of the lower limbs.
http://purl.obolibrary.org/obo/HP_0006496	Aplasia/hypoplasia involving bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		Absence (due to failure to form) or underdevelopment of the bones of the upper limbs.
http://purl.obolibrary.org/obo/HP_0006499	Abnormal femoral epiphysis morphology	http://purl.obolibrary.org/obo/HP_0006500	Abnormal lower limb epiphysis morphology		An anomaly of a growth plate of a femur.
http://purl.obolibrary.org/obo/HP_0006500	Abnormal lower limb epiphysis morphology	http://purl.obolibrary.org/obo/HP_0006505	Abnormal limb epiphysis morphology		An anomaly of one or more epiphyses of one or both legs.
http://purl.obolibrary.org/obo/HP_0006503	Aplasia/hypoplasia involving forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		Absence (due to failure to form) or underdevelopment of one or more forearm bones.
http://purl.obolibrary.org/obo/HP_0006509	Diverticulosis of trachea	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		Tracheal diverticula are blind-ended outpouchings arising from the trachea. They are usually an incidental finding. Occasionally they can mimic pneumomediastinum. Tracheal diverticula are either congenital or acquired, in the latter case the most common causes are prolonged increased intraluminal pressure, e.g. chronic cough, COPD, tracheomalacia, and iatrogenic (e.g. post-surgical).
http://purl.obolibrary.org/obo/HP_0006510	Chronic pulmonary obstruction	http://purl.obolibrary.org/obo/HP_0006536	Airway obstruction		An anomaly that is characterized progressive airflow obstruction that is only partly reversible, inflammation in the airways, and systemic effects or comorbities.
http://purl.obolibrary.org/obo/HP_0006511	Laryngeal stridor	http://purl.obolibrary.org/obo/HP_0025424	Abnormal larynx physiology		An abnormal high-pitched noisy sound, occurring during inhalation or exhalation caused by the incomplete obstruction in the throat.
http://purl.obolibrary.org/obo/HP_0006516	Hypersensitivity pneumonitis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Hypersensitivity pneumonitis involves inhalation of an antigen. This leads to an exaggerated immune response and a following inflammation of the alveoli within the lungs. The main feature of chronic hypersensitivity pneumonitis on lung biopsies is expansion of the interstitium by lymphocytes accompanied by an occasional multinucleated giant cell or loose granuloma. After exposure to the provoking antigen, following symptoms can be seen: fever, chills, malaise, cough, hemoptysis, chest tightness, dyspnea, rash, swelling and headache and can be completely reversible, based on the duration of the illness, categorized as acute (HP:0011009), subacute (HP:0011011), and chronic (HP:0011010).
http://purl.obolibrary.org/obo/HP_0006517	Intraalveolar phospholipid accumulation	http://purl.obolibrary.org/obo/HP_0032973	Abnormal bronchoalveolar lavage fluid morphology		Accumulation of amorphous PAS-positive material in the space between alveolar macrophages, sometimes as condensed form (oval bodies) are typically found in alveolar proteinosis.
http://purl.obolibrary.org/obo/HP_0006518	Pulmonary venous occlusion	http://purl.obolibrary.org/obo/HP_0030968	Abnormal pulmonary vein morphology		Substantial narrowing or blockage of small pulmonary veins as a result of disorganized smooth muscle hypertrophy and collagen matrix deposition.
http://purl.obolibrary.org/obo/HP_0006519	Alveolar cell carcinoma	http://purl.obolibrary.org/obo/HP_0100552	Neoplasm of the tracheobronchial system		Adenocarcinoma of the Bronchus.
http://purl.obolibrary.org/obo/HP_0006521	Pulmonary lymphangiectasia	http://purl.obolibrary.org/obo/HP_0031842	Lymphangiectasis		Abnormal dilatation of the pulmonary lymphatic vessels. Lymphatic fluid in the lung is derived from normal leakage of fluid out of the blood capillaries in the lung. In pulmonary lymphangiectasia, the pulmonary lymphatics are not properly connected and become dilated with fluid.
http://purl.obolibrary.org/obo/HP_0006527	Lymphocytic interstitial pneumonia	http://purl.obolibrary.org/obo/HP_0033582	Pulmonary interstitial lymphocyte infiltration		Lymphocytic interstitial pneumonitis is a benign lymphoproliferative disorder of the lung that is characterized by the presence of a dense, predominantly lymphocytic interstitial infiltrate (lymphocytes, plasma cells, other elements of the lymphoreticular system) that expands the alveolar septa.
http://purl.obolibrary.org/obo/HP_0006528	Chronic lung disease	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		According to the definitions of the American and British Thoracic Societies, including pulmonary functional tests, X-rays, and CT scans for items such as fibrosis, bronchiectasis, bullae, emphysema, nodular or lymphomatous abnormalities.
http://purl.obolibrary.org/obo/HP_0006529	Abnormal pulmonary lymphatics	http://purl.obolibrary.org/obo/HP_0100763	Abnormality of the lymphatic system		An abnormality of the pulmonary lymphatic chain.
http://purl.obolibrary.org/obo/HP_0006532	Recurrent pneumonia	http://purl.obolibrary.org/obo/HP_0002090	Pneumonia		An increased susceptibility to pneumonia as manifested by a history of recurrent episodes of pneumonia.
http://purl.obolibrary.org/obo/HP_0006535	Recurrent intrapulmonary hemorrhage	http://purl.obolibrary.org/obo/HP_0040223	Pulmonary hemorrhage		A recurrent hemorrhage occurring within the lung.
http://purl.obolibrary.org/obo/HP_0006536	Airway obstruction	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Obstruction of conducting airways of the lung.
http://purl.obolibrary.org/obo/HP_0006538	Recurrent bronchopulmonary infections	http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections		An increased susceptibility to bronchopulmonary infections as manifested by a history of recurrent bronchopulmonary infections.
http://purl.obolibrary.org/obo/HP_0006544	Extrapulmonary lobar sequestration	http://purl.obolibrary.org/obo/HP_0100632	Pulmonary sequestration		A type of pulmonary sequestration that is completely enclosed in its own pleural sac, occurring above, within, or below the diaphragm, and without communication with the tracheobronchial tree.
http://purl.obolibrary.org/obo/HP_0006548	Pulmonary arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		Pulmonary arteriovenous malformation, a condition most commonly associated with hereditary hemorrhagic telangiectasia, is an abnormal communication between the pulmonary artery and pulmonary vein without an intervening capillary communication. HRCT images usually show a coarse spidery appearance of the peripheral vascular markings in the lungs. More specific findings are obtained in the pulmonary angiogram where the normally invisible capillary phase is replaced by irregular vascular channels bridging the peripheral branches of pulmonary arteries and veins.
http://purl.obolibrary.org/obo/HP_0006554	Acute hepatic failure	http://purl.obolibrary.org/obo/HP_0001399	Hepatic failure		Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver.
http://purl.obolibrary.org/obo/HP_0006555	Diffuse hepatic steatosis	http://purl.obolibrary.org/obo/HP_0001397	Hepatic steatosis		A diffuse form of hepatic steatosis.
http://purl.obolibrary.org/obo/HP_0006558	Decreased mitochondrial complex III activity in liver tissue	http://purl.obolibrary.org/obo/HP_0025155	Abnormal hepatobiliary system physiology		Decreased activity of complex III of the mitochondrion in the liver.
http://purl.obolibrary.org/obo/HP_0006559	Hepatic calcification	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		The presence of abnormal calcium deposition in the liver.
http://purl.obolibrary.org/obo/HP_0006560	Biliary hyperplasia	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Hyperplasia of the biliary tree, as manifested by increased size of bile ducts, dilated lumen, and histologically by an increased number of epithelial cells or hyperplasia.
http://purl.obolibrary.org/obo/HP_0006564	Fluctuating hepatomegaly	http://purl.obolibrary.org/obo/HP_0002240	Hepatomegaly		Intermittently increased size of the liver.
http://purl.obolibrary.org/obo/HP_0006565	Increased hepatocellular lipid droplets	http://purl.obolibrary.org/obo/HP_0006561	Lipid accumulation in hepatocytes		An abnormal increase in the amount of intracellular lipid droplets in hepatocytes.
http://purl.obolibrary.org/obo/HP_0006568	Increased hepatic glycogen content	http://purl.obolibrary.org/obo/HP_0500030	Abnormal hepatic glycogen storage		An increase in the amount of glycogen stored in hepatocytes compared to normal.
http://purl.obolibrary.org/obo/HP_0006571	Reduced number of intrahepatic bile ducts	http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology		The presence of reduced numbers of intrahepatic bile duct than normal.
http://purl.obolibrary.org/obo/HP_0006573	Acute hepatic steatosis	http://purl.obolibrary.org/obo/HP_0001397	Hepatic steatosis		An acute form of hepatic steatosis.
http://purl.obolibrary.org/obo/HP_0006577	Macronodular cirrhosis	http://purl.obolibrary.org/obo/HP_0001394	Cirrhosis		A type of cirrhosis characterized by the presence of large regenerative nodules.
http://purl.obolibrary.org/obo/HP_0006579	Prolonged neonatal jaundice	http://purl.obolibrary.org/obo/HP_0000952	Jaundice		Neonatal jaundice refers to a yellowing of the skin and other tissues of a newborn infant as a result of increased concentrations of bilirubin in the blood. Neonatal jaundice affects over half of all newborns to some extent in the first week of life. Prolonged neonatal jaundice is said to be present if the jaundice persists for longer than 14 days in term infants and 21 days in preterm infants.
http://purl.obolibrary.org/obo/HP_0006580	Portal fibrosis	http://purl.obolibrary.org/obo/HP_0004297	Abnormality of the biliary system		Fibroblast proliferation and fiber expansion from the portal areas to the lobule.
http://purl.obolibrary.org/obo/HP_0006581	Depletion of mitochondrial DNA in liver	http://purl.obolibrary.org/obo/HP_0030059	Mitochondrial depletion		An abnormal reduction in the number of mitochondria in hepatocytes.
http://purl.obolibrary.org/obo/HP_0006582	Reye syndrome-like episodes	http://purl.obolibrary.org/obo/HP_0025155	Abnormal hepatobiliary system physiology		Repeated occurrences of acute noninflammatory encephalopathy and fatty degenerative liver failure.
http://purl.obolibrary.org/obo/HP_0006585	Congenital pseudoarthrosis of the clavicle	http://purl.obolibrary.org/obo/HP_0005864	Pseudoarthrosis		The two portions of the clavicle (corresponding to the two primary ossification centers of the clavicle) are connected by a fibrous bridge that is contiguous with the periosteum, and a synovial membrane develops, resulting in a clavicle with a bipartite appearance radiographically. Congenital pseudarthrosis of the clavicle generally presents as a painless mass or swelling over the clavicle.
http://purl.obolibrary.org/obo/HP_0006587	Straight clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		An abnormally straight configuration of the clavicle, a tubular bone which normally is doubly curved .
http://purl.obolibrary.org/obo/HP_0006590	Premature sternal synostosis	http://purl.obolibrary.org/obo/HP_0006714	Aplasia/Hypoplasia of the sternum		Prematurely closed sternal sutures.
http://purl.obolibrary.org/obo/HP_0006591	Absent glenoid fossa	http://purl.obolibrary.org/obo/HP_0011912	Abnormality of the glenoid fossa		Lack of development of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus.
http://purl.obolibrary.org/obo/HP_0006595	Scapulohumeral synostosis	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		Bony fusion between the humerus and scapula, leading to an impairment in mobility of the affected shoulder joint.
http://purl.obolibrary.org/obo/HP_0006597	Diaphragmatic paralysis	http://purl.obolibrary.org/obo/HP_0009113	Diaphragmatic weakness		The presence of a paralyzed diaphragm.
http://purl.obolibrary.org/obo/HP_0006606	Irregular chondrocostal junctions	http://purl.obolibrary.org/obo/HP_0000919	Abnormality of the costochondral junction		Irregular surface of the normally relatively smooth border between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum.
http://purl.obolibrary.org/obo/HP_0006607	Precocious costochondral ossification	http://purl.obolibrary.org/obo/HP_0012306	Abnormal rib ossification		Early ossification of the costochondral junction, which is the joint between the ribs and costal cartilage in the front of the rib cage.
http://purl.obolibrary.org/obo/HP_0006608	Midclavicular hypoplasia	http://purl.obolibrary.org/obo/HP_0000894	Short clavicles		Underdevelopment of the middle portion of the clavicle.
http://purl.obolibrary.org/obo/HP_0006610	Wide intermamillary distance	http://purl.obolibrary.org/obo/HP_0040157	Abnormal intermamillary distance		A larger than usual distance between the left and right nipple.
http://purl.obolibrary.org/obo/HP_0006611	Decreased number of sternal ossification centers	http://purl.obolibrary.org/obo/HP_0011863	Abnormal sternal ossification		A less than normal number of sternal ossification centers. The sternum is initially formed from bilateral sternal plates that chondrify and begin to fuse with ribs at 10 weeks gestational age. Ossification starts in the manubrium and upper part of the sternal body at the 6th month, in the middle of the sternal body at the 7th month, in the lower part of the body during the 1st postnatal year and in the xiphoid process between years 5 and 18. The number of ossification centers vary up to six, and it is the ossification centers that are visualized by prenatal ultrasound. This term describes a reduction in the number of ossification centers compared with age-related norms.
http://purl.obolibrary.org/obo/HP_0006615	Absent in utero rib ossification	http://purl.obolibrary.org/obo/HP_0012306	Abnormal rib ossification		Lack of formation and mineralization of the ribs in utero.
http://purl.obolibrary.org/obo/HP_0006619	Anterior rib punctate calcifications	http://purl.obolibrary.org/obo/HP_0012306	Abnormal rib ossification		Deposition of calcium salts in point-like foci within the anterior portion of one or more ribs.
http://purl.obolibrary.org/obo/HP_0006623	Costochondral joint sclerosis	http://purl.obolibrary.org/obo/HP_0000919	Abnormality of the costochondral junction		Abnormal increase in density of the tissue at the costochondral junctions.
http://purl.obolibrary.org/obo/HP_0006625	Multifocal breast carcinoma	http://purl.obolibrary.org/obo/HP_0003002	Breast carcinoma		Breast carcinoma that is bilateral or otherwise multifocal.
http://purl.obolibrary.org/obo/HP_0006628	Absent sternal ossification	http://purl.obolibrary.org/obo/HP_0011863	Abnormal sternal ossification		Lack of formation of mineralized bony tissue of the sternum.
http://purl.obolibrary.org/obo/HP_0006633	Glenoid fossa hypoplasia	http://purl.obolibrary.org/obo/HP_0011912	Abnormality of the glenoid fossa		Underdevelopment of the glenoid fossa, which is the cavity in the lateral part of the scapula which articulates with the head of the humerus.
http://purl.obolibrary.org/obo/HP_0006634	Osteosclerosis of ribs	http://purl.obolibrary.org/obo/HP_0012306	Abnormal rib ossification		Osteosclerosis of ribs (increased density related to increased bone mass).
http://purl.obolibrary.org/obo/HP_0006638	Midclavicular aplasia	http://purl.obolibrary.org/obo/HP_0006710	Aplasia/Hypoplasia of the clavicles		Developmental defect resulting in congenital absence of the middle portion of the clavicle.
http://purl.obolibrary.org/obo/HP_0006640	Multiple rib fractures	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		More than one fracture of the ribs. Callus formation around multiple rib fractures can produce a row of multiple rounded expansions (beadlike prominences) giving the appearance of beaded ribs. Note that rachitic rosary would have one bead per rib (a swelling at the costochondral junction), while beaded ribs in the context of multiple rib fractures have multiple beads (fractures) along the same rib.
http://purl.obolibrary.org/obo/HP_0006645	Thin clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		Abnormally reduced diameter (cross section) of the clavicles.
http://purl.obolibrary.org/obo/HP_0006646	Costal cartilage calcification	http://purl.obolibrary.org/obo/HP_0012306	Abnormal rib ossification		Calcification of the costal cartilages, which are bars of hyaline cartilage found at the anterior ends of the ribs which serve to prolong the ribs forward and contribute to the elasticity of the walls of the thorax.
http://purl.obolibrary.org/obo/HP_0006649	Costochondral pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		Chest wall pain in the area of the costochondral junctions.
http://purl.obolibrary.org/obo/HP_0006660	Aplastic clavicle	http://purl.obolibrary.org/obo/HP_0006710	Aplasia/Hypoplasia of the clavicles		Absence of the clavicles as a developmental defect.
http://purl.obolibrary.org/obo/HP_0006665	Coat hanger sign of ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		An abnormal morphology of the ribs consisting of shorted, abnormally curved ribs. On posteroanterior chest radiography, the ribs show a curvature resembling that of a coat hanger (clothes hanger).
http://purl.obolibrary.org/obo/HP_0006677	Prolonged QRS complex	http://purl.obolibrary.org/obo/HP_0025074	Abnormal QRS complex		Increased time for the complex comprised of the Q wave, R wave, and S wave as measured by the electrocardiogram (EKG).. In adults, normal values are 0.06 - 0.10 sec.
http://purl.obolibrary.org/obo/HP_0006679	Granulomatous coronary arteritis	http://purl.obolibrary.org/obo/HP_0012089	Arteritis		Inflammation of the coronary arteries involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells.
http://purl.obolibrary.org/obo/HP_0006682	Premature ventricular contraction	http://purl.obolibrary.org/obo/HP_0004308	Ventricular arrhythmia		Premature ventricular contractions (PVC) or ventricular extrasystoles are premature contractions of the heart that arise in response to an impulse in the ventricles rather than the normal impulse from the sinoatrial (SA) node.
http://purl.obolibrary.org/obo/HP_0006683	Abnormal ventricular filling	http://purl.obolibrary.org/obo/HP_0030872	Abnormal cardiac ventricular function		An abnormality of filling of a ventricle with blood during diastole.
http://purl.obolibrary.org/obo/HP_0006684	Ventricular preexcitation with multiple accessory pathways	http://purl.obolibrary.org/obo/HP_0004309	Ventricular preexcitation		A form of ventricular preexcitation due to the presence of multiple accessory pathways for cardiac conduction.
http://purl.obolibrary.org/obo/HP_0006687	Aortic tortuosity	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Abnormal tortuous (i.e., twisted) form of the aorta.
http://purl.obolibrary.org/obo/HP_0006689	Bacterial endocarditis	http://purl.obolibrary.org/obo/HP_0100584	Endocarditis		A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves.
http://purl.obolibrary.org/obo/HP_0006690	Myocardial calcification	http://purl.obolibrary.org/obo/HP_0011915	Cardiovascular calcification		Calcium deposition in the myocardium.
http://purl.obolibrary.org/obo/HP_0006691	Pulmonic valve myxoma	http://purl.obolibrary.org/obo/HP_0001641	Abnormal pulmonary valve morphology		A benign tumor of connective tissue containing mucous or gelatinous material (myxoma) localized in the pumonic valve.
http://purl.obolibrary.org/obo/HP_0006692	Short chordae tendineae of the tricuspid valve	http://purl.obolibrary.org/obo/HP_0031442	Abnormal tricuspid chordae tendinae morphology		Abnormally short chordae tendineae of the tricuspid valve.
http://purl.obolibrary.org/obo/HP_0006693	Myocardial steatosis	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		Steatosis in the myocardium.
http://purl.obolibrary.org/obo/HP_0006698	Dilatation of the ventricular cavity	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		A localized outpouching of ventricular cavity that is generally associated with dyskinesia and paradoxical expansion during systole.
http://purl.obolibrary.org/obo/HP_0006699	Premature atrial contractions	http://purl.obolibrary.org/obo/HP_0005115	Supraventricular arrhythmia		A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites.
http://purl.obolibrary.org/obo/HP_0006702	Coronary artery dissection	http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology		Acute occurrence of a dissection (tear within the tunica intima and entry of blood into the tunica media) of a coronary artery.
http://purl.obolibrary.org/obo/HP_0006721	Acute lymphoblastic leukemia	http://purl.obolibrary.org/obo/HP_0002488	Acute leukemia		A form of acute leukemia characterized by excess lympoblasts.
http://purl.obolibrary.org/obo/HP_0006725	Pancreatic adenocarcinoma	http://purl.obolibrary.org/obo/HP_0002894	Neoplasm of the pancreas		The presence of an adenocarcinoma of the pancreas.
http://purl.obolibrary.org/obo/HP_0006727	T-cell acute lymphoblastic leukemias	http://purl.obolibrary.org/obo/HP_0006721	Acute lymphoblastic leukemia		Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females.
http://purl.obolibrary.org/obo/HP_0006729	Retroperitoneal paraganglioma	http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system		A paraganglioma (previously referred to as chemodectoma) located in the retroperitoneal space. Paragangliomas (also known as extra-adrenal pheochromocytomas) are rare tumors that arise from extra-adrenal chromaffin cells. Paragangliomas are characterized by secretions of excessive catecholamines, including epinephrine, norepinephrine and dopamine, which may lead to clinical symptoms, including episodic hypertension, tachycardia and diaphoresis. However, between 40 and 50% of paragangliomas are non-functional.
http://purl.obolibrary.org/obo/HP_0006731	Follicular thyroid carcinoma	http://purl.obolibrary.org/obo/HP_0002890	Thyroid carcinoma		The presence of an follicular adenocarcinoma of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0006732	Papillary renal cell carcinoma type 2	http://purl.obolibrary.org/obo/HP_0006766	Papillary renal cell carcinoma		A type of papillary renal cell carcinoma in which the papillae are covered by large eosinophilic cells with pleomorphic nuclei, prominent nucleoli, and nuclear pseudostratification.
http://purl.obolibrary.org/obo/HP_0006733	Acute megakaryocytic leukemia	http://purl.obolibrary.org/obo/HP_0002488	Acute leukemia		A rare subtype of acute myeloid leukemia evolving from primitive megakaryoblasts.
http://purl.obolibrary.org/obo/HP_0006735	Renal cortical adenoma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		The presence of an adenoma in the cortex of the kidney.
http://purl.obolibrary.org/obo/HP_0006737	Extraadrenal pheochromocytoma	http://purl.obolibrary.org/obo/HP_0002666	Pheochromocytoma		Pheochromocytoma not originating from the adrenal medulla but from another source such as from chromaffin cells in or about sympathetic ganglia.
http://purl.obolibrary.org/obo/HP_0006739	Squamous cell carcinoma of the skin	http://purl.obolibrary.org/obo/HP_0002860	Squamous cell carcinoma		Squamous cell carcinoma of the skin is a malignant tumor of squamous epithelium.
http://purl.obolibrary.org/obo/HP_0006740	Transitional cell carcinoma of the bladder	http://purl.obolibrary.org/obo/HP_0002862	Bladder carcinoma		The presence of a carcinoma of the urinary bladder with origin in a transitional epithelial cell.
http://purl.obolibrary.org/obo/HP_0006744	Adrenocortical carcinoma	http://purl.obolibrary.org/obo/HP_0100641	Neoplasm of the adrenal cortex		A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone.
http://purl.obolibrary.org/obo/HP_0006748	Adrenal pheochromocytoma	http://purl.obolibrary.org/obo/HP_0100642	Neoplasm of the adrenal medulla		Pheochromocytoma originating from the adrenal medulla.
http://purl.obolibrary.org/obo/HP_0006751	Paraspinal neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized adjacent to the spine.
http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A tumor (abnormal growth of tissue) of the stomach.
http://purl.obolibrary.org/obo/HP_0006755	Cutaneous leiomyosarcoma	http://purl.obolibrary.org/obo/HP_0100243	Leiomyosarcoma		The presence of leiomyosarcoma of the skin.
http://purl.obolibrary.org/obo/HP_0006758	Malignant genitourinary tract tumor	http://purl.obolibrary.org/obo/HP_0007379	Neoplasm of the genitourinary tract		The presence of a malignant neoplasm of the genital system.
http://purl.obolibrary.org/obo/HP_0006762	Renal pelvic carcinoma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		The presence of a carcinoma in the renal pelvis.
http://purl.obolibrary.org/obo/HP_0006765	Chondrosarcoma	http://purl.obolibrary.org/obo/HP_0100242	Sarcoma		A slowly growing malignant neoplasm derived from cartilage cells.
http://purl.obolibrary.org/obo/HP_0006766	Papillary renal cell carcinoma	http://purl.obolibrary.org/obo/HP_0005584	Renal cell carcinoma		The presence of renal cell carcinoma in the renal papilla.
http://purl.obolibrary.org/obo/HP_0006767	Pituitary prolactin cell adenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women.
http://purl.obolibrary.org/obo/HP_0006770	Clear cell renal cell carcinoma	http://purl.obolibrary.org/obo/HP_0005584	Renal cell carcinoma		A subtype of renal cell carcinoma thought to originate from mature renal tubular cells in the proximal tubule of the nehpron.
http://purl.obolibrary.org/obo/HP_0006771	Duodenal adenocarcinoma	http://purl.obolibrary.org/obo/HP_0040274	Adenocarcinoma of the small intestine		A malignant epithelial tumor with a glandular organization that originates in the duodenum.
http://purl.obolibrary.org/obo/HP_0006772	Renal angiomyolipoma	http://purl.obolibrary.org/obo/HP_0008696	Renal hamartoma		A benign renal neoplasm composed of fat, vascular, and smooth muscle elements.
http://purl.obolibrary.org/obo/HP_0006774	Ovarian papillary adenocarcinoma	http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm		The presence of a papillary adenocarcinoma of the ovary.
http://purl.obolibrary.org/obo/HP_0006775	Multiple myeloma	http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm		A malignant plasma cell tumor growing within soft tissue or within the skeleton.
http://purl.obolibrary.org/obo/HP_0006778	Benign genitourinary tract neoplasm	http://purl.obolibrary.org/obo/HP_0007379	Neoplasm of the genitourinary tract		A non-malignant neoplasm of the genitourinary system.
http://purl.obolibrary.org/obo/HP_0006780	Parathyroid carcinoma	http://purl.obolibrary.org/obo/HP_0100733	Neoplasm of the parathyroid gland		A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism.
http://purl.obolibrary.org/obo/HP_0006781	Hurthle cell thyroid adenoma	http://purl.obolibrary.org/obo/HP_0000854	Thyroid adenoma		A kind of thyroid adenoma characterized by the presence of oxyphil cells.
http://purl.obolibrary.org/obo/HP_0006784	Paranasal sinus hypoplasia	http://purl.obolibrary.org/obo/HP_0005453	Absent/hypoplastic paranasal sinuses		Underdevelopment of the paranasal sinuses.
http://purl.obolibrary.org/obo/HP_0006785	Limb-girdle muscular dystrophy	http://purl.obolibrary.org/obo/HP_0003560	Muscular dystrophy		Muscular dystrophy affecting the muscles of the limb girdle (the hips and shoulders).
http://purl.obolibrary.org/obo/HP_0006803	Vivid hallucination	http://purl.obolibrary.org/obo/HP_0002367	Visual hallucination		Perceptual experiences that are vivid, intense, and sensory in nature occur in the absence of corresponding stimuli from the external environment.
http://purl.obolibrary.org/obo/HP_0006808	Cerebral hypomyelination	http://purl.obolibrary.org/obo/HP_0003429	CNS hypomyelination		Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the white matter of the central nervous system.
http://purl.obolibrary.org/obo/HP_0006812	Abnormal posterior periventricular white matter morphology	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		An anomaly of the white matter of the brain localized in the region posterior to the cerebral ventricles.
http://purl.obolibrary.org/obo/HP_0006813	Focal hemiclonic seizure	http://purl.obolibrary.org/obo/HP_0002266	Focal clonic seizure		A type of focal clonic seizure characterized by sustained rhythmic jerking rapidly involves one side of the body at seizure onset.
http://purl.obolibrary.org/obo/HP_0006818	4-layered lissencephaly	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		A form of lissencephaly in which the cortex is thickened and has four more or less disorganized layers rather than six normal layers resulting from incomplete neuronal migration during brain development. At neuropathological examination, a 4-layered cortex consists of an upper molecular layer, a second thin cellular layer containing pyramidal neurons usually observed in layer V, a third pale poorly cellular layer and a fourth thick deep layer made up of neurons which had failed to migrate. Radiologocally would manifest as agyria or pachygyria with cortical thickness greater than 10 mm.
http://purl.obolibrary.org/obo/HP_0006821	Frontal polymicrogyria	http://purl.obolibrary.org/obo/HP_0002126	Polymicrogyria		A type of polymicrogyria with a gradient of severity (anterior more severe than posterior) extending from frontal poles posteriorly to precentral gyrus and inferiorly to frontal operculum.
http://purl.obolibrary.org/obo/HP_0006825	Pallor of dorsal columns of the spinal cord	http://purl.obolibrary.org/obo/HP_0011397	Abnormal spinal cord dorsal column morphology		An abnormally pale appearance of the dorsal portion of the gray substance of the spinal cord. This finding can be observed by histological examination.
http://purl.obolibrary.org/obo/HP_0006829	Severe muscular hypotonia	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		A severe degree of muscular hypotonia characterized by markedly reduced muscle tone.
http://purl.obolibrary.org/obo/HP_0006834	Developmental stagnation at onset of seizures	http://purl.obolibrary.org/obo/HP_0007281	Developmental stagnation		A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills, following the onset of epilepsy.
http://purl.obolibrary.org/obo/HP_0006837	Congenital Horner syndrome	http://purl.obolibrary.org/obo/HP_0002277	Horner syndrome		A type of Horner syndrome with congenital onset.
http://purl.obolibrary.org/obo/HP_0006844	Absent patellar reflexes	http://purl.obolibrary.org/obo/HP_0002522	Areflexia of lower limbs		Absence of the knee jerk reflex, which can normally be elicited by tapping the patellar tendon with a reflex hammer just below the patella.
http://purl.obolibrary.org/obo/HP_0006849	Hypodysplasia of the corpus callosum	http://purl.obolibrary.org/obo/HP_0002079	Hypoplasia of the corpus callosum		Developmental defect characterized by a small and malformed corpus callosum.
http://purl.obolibrary.org/obo/HP_0006850	Hypoplasia of the ventral pons	http://purl.obolibrary.org/obo/HP_0012110	Hypoplasia of the pons		Underdevelopment of the ventral portion of the pons.
http://purl.obolibrary.org/obo/HP_0006851	Symmetric spinal nerve root neurofibromas	http://purl.obolibrary.org/obo/HP_0009735	Spinal neurofibroma		Multiple neurofibromas of the spinal nerve roots with a symmetric distribution.
http://purl.obolibrary.org/obo/HP_0006852	Episodic generalized hypotonia	http://purl.obolibrary.org/obo/HP_0001290	Generalized hypotonia		The occurrence of repeated episodes of generalized muscular hypotonia.
http://purl.obolibrary.org/obo/HP_0006855	Cerebellar vermis atrophy	http://purl.obolibrary.org/obo/HP_0002334	Abnormal cerebellar vermis morphology		Wasting (atrophy) of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0006858	Impaired distal proprioception	http://purl.obolibrary.org/obo/HP_0010831	Impaired proprioception		A loss or impairment of the sensation of the relative position of parts of the body and joint position occurring at distal joints.
http://purl.obolibrary.org/obo/HP_0006863	Severe expressive language delay	http://purl.obolibrary.org/obo/HP_0002474	Expressive language delay		A severe delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.
http://purl.obolibrary.org/obo/HP_0006870	Lobar holoprosencephaly	http://purl.obolibrary.org/obo/HP_0001360	Holoprosencephaly		A type of holoprosencephaly in which most of the right and left cerebral hemispheres and lateral ventricles are separated but the most rostral aspect of the telencephalon, the frontal lobes, are fused, especially ventrally.
http://purl.obolibrary.org/obo/HP_0006873	Symmetrical progressive peripheral demyelination	http://purl.obolibrary.org/obo/HP_0007262	Symmetric peripheral demyelination		A symmetric and progressive loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0006879	Pontocerebellar atrophy	http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology		Atrophy affecting the pons and the cerebellum.
http://purl.obolibrary.org/obo/HP_0006880	Cerebellar hemangioblastoma	http://purl.obolibrary.org/obo/HP_0010797	Hemangioblastoma		A hemangioblastoma of the cerebellum.
http://purl.obolibrary.org/obo/HP_0006881	Diffuse peripheral demyelination	http://purl.obolibrary.org/obo/HP_0011096	Peripheral demyelination		A diffuse loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0006886	Impaired distal vibration sensation	http://purl.obolibrary.org/obo/HP_0002495	Impaired vibratory sensation		A decrease in the ability to perceive vibration in the distal portions of the limbs.
http://purl.obolibrary.org/obo/HP_0006889	Borderline intellectual disability	http://purl.obolibrary.org/obo/HP_0001249	Intellectual disability		Borderline intellectual disability is defined as an intelligence quotient (IQ) in the range of 70-85.
http://purl.obolibrary.org/obo/HP_0006892	Frontotemporal cerebral atrophy	http://purl.obolibrary.org/obo/HP_0002059	Cerebral atrophy		Atrophy (wasting, decrease in size of cells or tissue) affecting the frontotemporal cerebrum.
http://purl.obolibrary.org/obo/HP_0006896	Hypnopompic hallucination	http://purl.obolibrary.org/obo/HP_4000063	Sleep related hallucination		Hallucinations occurring during the transition from sleep to wakefulness.
http://purl.obolibrary.org/obo/HP_0006897	Abducens palsy	http://purl.obolibrary.org/obo/HP_0006824	Cranial nerve paralysis		Malfunction of the abducens nerve as manifested by impairment of the ability of the affected eye to be moved outward. Patients who develop abducens nerve palsy often present with binocular horizontal diplopia, which is a double vision when looking at objects side by side. There will be a notable weakness of the ipsilateral lateral rectus muscle leading to a deficit in of eye abduction on the affected side. Some patients may present with a constant head turning movement to maintain binocular fusion and to lessen the degree of diplopia.
http://purl.obolibrary.org/obo/HP_0006906	Congenital intracerebral calcification	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		The presence of calcium deposition within brain structures that is present already at the time of birth.
http://purl.obolibrary.org/obo/HP_0006913	Frontal cortical atrophy	http://purl.obolibrary.org/obo/HP_0002120	Cerebral cortical atrophy		Atrophy of the frontal cortex.
http://purl.obolibrary.org/obo/HP_0006916	Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material	http://purl.obolibrary.org/obo/HP_0003205	Curvilinear intracellular accumulation of autofluorescent lipopigment storage material		Curvilinear intracellular accumulation of autofluorescent lipopigment storage material within axons.
http://purl.obolibrary.org/obo/HP_0006921	Axial muscle stiffness	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		Stiffness (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) of the axial musculature.
http://purl.obolibrary.org/obo/HP_0006927	Unilateral polymicrogyria	http://purl.obolibrary.org/obo/HP_0002126	Polymicrogyria		Excessive number of small gyri (convolutions) on the surface of one side of the brain.
http://purl.obolibrary.org/obo/HP_0006929	Hypoglycemic encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		Brain damage related to a lowering of blood glucose below a critical level (around 30 mg/dl), which may lead to confusion, lethargy and delirium followed by seizures and coma. Prolonged hypoglycemia may lead to irreversible brain damage.
http://purl.obolibrary.org/obo/HP_0006930	Frontoparietal cortical dysplasia	http://purl.obolibrary.org/obo/HP_0002539	Cortical dysplasia		The presence of developmental dysplasia of the cortex of frontal lobe and the cortex of parietal lobe.
http://purl.obolibrary.org/obo/HP_0006931	Pericallosal lipoma	http://purl.obolibrary.org/obo/HP_0006866	Midline central nervous system lipomas		Pericallosal lipomas are congenital soft masses of adipose cells encapsulated by a thin layer of fibrous tissue, appearing adjacent to the corpus callosum of the brain.
http://purl.obolibrary.org/obo/HP_0006932	Transient psychotic episodes	http://purl.obolibrary.org/obo/HP_5200430	Abnormal psychotic pattern		Relatively short-lived periods of psychosis are characterized by the sudden onset of severe disturbances in perception, thinking, and behavior. These episodes typically last for a brief duration, generally ranging from a few days to a few weeks, and are often triggered by a significant stressor or traumatic event.
http://purl.obolibrary.org/obo/HP_0006934	Congenital nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		Nystagmus dating from or present at birth.
http://purl.obolibrary.org/obo/HP_0006937	Impaired distal tactile sensation	http://purl.obolibrary.org/obo/HP_0010830	Impaired tactile sensation		A reduced sense of touch (tactile sensation) on the skin of the distal limbs. This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus.
http://purl.obolibrary.org/obo/HP_0006938	Impaired vibration sensation at ankles	http://purl.obolibrary.org/obo/HP_0006886	Impaired distal vibration sensation		A decrease in the ability to perceive vibration at the ankles. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to the malleoli of the ankles.
http://purl.obolibrary.org/obo/HP_0006944	Abolished vibration sense	http://purl.obolibrary.org/obo/HP_0002495	Impaired vibratory sensation		A complete loss of the ability to perceive vibration.
http://purl.obolibrary.org/obo/HP_0006946	Recurrent meningitis	http://purl.obolibrary.org/obo/HP_0011450	Unusual CNS infection		An increased susceptibility to meningitis as manifested by a medical history of recurrent episodes of meningitis.
http://purl.obolibrary.org/obo/HP_0006955	Olivopontocerebellar hypoplasia	http://purl.obolibrary.org/obo/HP_0012110	Hypoplasia of the pons		Hypoplasia of the cerebellum, pontine nuclei, and inferior olivary nucleus.
http://purl.obolibrary.org/obo/HP_0006958	Abnormal auditory evoked potentials	http://purl.obolibrary.org/obo/HP_0430106	Abnormal brain-evoked potentials		An abnormality of the auditory evoked potentials, which are used to trace the signal generated by a sound, from the cochlear nerve, through the lateral lemniscus, to the medial geniculate nucleus, and to the cortex.
http://purl.obolibrary.org/obo/HP_0006959	Proximal spinal muscular atrophy	http://purl.obolibrary.org/obo/HP_0007269	Spinal muscular atrophy		Proximal spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.
http://purl.obolibrary.org/obo/HP_0006960	Choroid plexus calcification	http://purl.obolibrary.org/obo/HP_0430048	Intracranial calcification		The presence of calcium deposition in the choroid plexus.
http://purl.obolibrary.org/obo/HP_0006970	Periventricular leukomalacia	http://purl.obolibrary.org/obo/HP_0002518	Abnormal periventricular white matter morphology		Periventricular leukomalacia is characterized by diffuse injury of deep cerebral white matter, accompanied in its most severe form by focal necrosis. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia.
http://purl.obolibrary.org/obo/HP_0006976	Necrotizing encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		A type of encephalopathy (brain disease, damage, or malfunction accompanied by an altered mental state) that is characterized by evidence of necrosis of brain tissue.
http://purl.obolibrary.org/obo/HP_0006977	Deficit in grammar	http://purl.obolibrary.org/obo/HP_0002463	Language impairment		Deficit in grammar, including syntax and morphology.
http://purl.obolibrary.org/obo/HP_0006979	Sleep-wake cycle disturbance	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		Any abnormality of an individual's circadian rhythm that affects the timing of sleeping and being awake is referred to as a sleep-wake disorder.
http://purl.obolibrary.org/obo/HP_0006980	Progressive leukoencephalopathy	http://purl.obolibrary.org/obo/HP_0002352	Leukoencephalopathy		Leukoencephalopathy that gets more severe with time.
http://purl.obolibrary.org/obo/HP_0006988	Alobar holoprosencephaly	http://purl.obolibrary.org/obo/HP_0001360	Holoprosencephaly		A type of holoprosencephaly characterized by the presence of a single ventricle and no separation of the cerebral hemisphere. The single midline ventricle is often greatly enlarged.
http://purl.obolibrary.org/obo/HP_0006990	Myelin-dependent gliosis	http://purl.obolibrary.org/obo/HP_0002171	Gliosis		A type of gliosis that occurs in the vicinity of injured neurons.
http://purl.obolibrary.org/obo/HP_0006999	Basal ganglia gliosis	http://purl.obolibrary.org/obo/HP_0002171	Gliosis		Focal proliferation of glial cells in the basal ganglia.
http://purl.obolibrary.org/obo/HP_0007002	Motor axonal neuropathy	http://purl.obolibrary.org/obo/HP_0003477	Peripheral axonal neuropathy		Progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg.
http://purl.obolibrary.org/obo/HP_0007007	Cavitation of the basal ganglia	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		The formation of small cavities in the tissue of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0007010	Poor fine motor coordination	http://purl.obolibrary.org/obo/HP_0002311	Incoordination		An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.
http://purl.obolibrary.org/obo/HP_0007011	Fourth cranial nerve palsy	http://purl.obolibrary.org/obo/HP_0006824	Cranial nerve paralysis		Paralysis of the fourth cranial (trochlear) nerve manifested as weakness of the superior oblique muscle which causes vertical diplopia that is maximal when the affected eye is adducted and directed inferiorly.
http://purl.obolibrary.org/obo/HP_0007015	Poor gross motor coordination	http://purl.obolibrary.org/obo/HP_0002311	Incoordination		An abnormality of the ability (skills) to perform a precise movement of large muscles with the intent to perform a specific act. Gross motor skills are required to mediate movements of the arms, legs, and other large body parts.
http://purl.obolibrary.org/obo/HP_0007018	Attention deficit hyperactivity disorder	http://purl.obolibrary.org/obo/HP_0000752	Hyperactivity		Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient.
http://purl.obolibrary.org/obo/HP_0007021	Pain insensitivity	http://purl.obolibrary.org/obo/HP_0007328	Impaired pain sensation		Inability to perceive painful stimuli.
http://purl.obolibrary.org/obo/HP_0007023	Antenatal intracerebral hemorrhage	http://purl.obolibrary.org/obo/HP_0001342	Cerebral hemorrhage		Cerebral hemorrhage that occurs before birth.
http://purl.obolibrary.org/obo/HP_0007024	Pseudobulbar paralysis	http://purl.obolibrary.org/obo/HP_0003470	Paralysis		Bilateral impairment of the function of the cranial nerves 9-12, which control musculature involved in eating, swallowing, and speech. Pseudobulbar paralysis is characterized clinically by dysarthria, dysphonia, and dysphagia with bifacial paralysis, and may be accompanied by Pseudobulbar behavioral symptoms such as enforced crying and laughing.
http://purl.obolibrary.org/obo/HP_0007027	Poorly formed metencephalon	http://purl.obolibrary.org/obo/HP_0011283	Abnormal metencephalon morphology		A morphological abnormality of the metencephalon.
http://purl.obolibrary.org/obo/HP_0007029	Cerebral berry aneurysm	http://purl.obolibrary.org/obo/HP_0004944	Dilatation of the cerebral artery		A small, sac-like aneurysm (outpouching) of a cerebral blood vessel.
http://purl.obolibrary.org/obo/HP_0007033	Cerebellar dysplasia	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		Cerebellar dysplasia (abnormal growth or development) is defined by abnormal cerebellar foliation, white matter arborization, and gray-white matter junction. Cerebellar dysplasia is a neuroimaging finding that describes abnormalities of both the cerebellar cortex and white matter and is associated with variable neurodevelopmental outcome. Dysplasia may globally involve the cerebellum or affect only one cerebellar hemisphere. In addition, cerebellar dysplasia may be associated with cortical/subcortical cysts.
http://purl.obolibrary.org/obo/HP_0007035	Anterior encephalocele	http://purl.obolibrary.org/obo/HP_0002084	Encephalocele		A type of congenital malformation in which brain tissue protrudes through a defect in the anterior (front) part of the skull.
http://purl.obolibrary.org/obo/HP_0007039	Symmetric T2-signal increase with T1-signal decrease in the putamen	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		A symmetric magnetic resonance imaing (MRI) abnormality of the basal ganglia characterized by an increase of signal intensity in T2-weighted images and a corresponding signal decrease on T1-weighted images.
http://purl.obolibrary.org/obo/HP_0007041	Chronic lymphocytic meningitis	http://purl.obolibrary.org/obo/HP_0001287	Meningitis		Meningitis that persists for more than 4 weeks, and lymphocytes are present in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0007047	Atrophy of the dentate nucleus	http://purl.obolibrary.org/obo/HP_0100321	Abnormal dentate nucleus morphology		Partial or complete wasting (loss) of dentate nucleus.
http://purl.obolibrary.org/obo/HP_0007048	Large basal ganglia	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		Increased size of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0007054	Proximal hyperreflexia	http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia		Hyperactive stretch reflexes of muscles that move proximal joints (elbow, knee).
http://purl.obolibrary.org/obo/HP_0007058	Generalized cerebral atrophy/hypoplasia	http://purl.obolibrary.org/obo/HP_0002059	Cerebral atrophy		Generalized atrophy or hypoplasia of the cerebrum.
http://purl.obolibrary.org/obo/HP_0007064	Progressive language deterioration	http://purl.obolibrary.org/obo/HP_0002344	Progressive neurologic deterioration		Progressive loss of previously present language abilities.
http://purl.obolibrary.org/obo/HP_0007066	Proximal limb muscle stiffness	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in the proximal limb muscle.
http://purl.obolibrary.org/obo/HP_0007067	Distal peripheral sensory neuropathy	http://purl.obolibrary.org/obo/HP_0000763	Sensory neuropathy		Peripheral sensory neuropathy affecting primarily distal sensation.
http://purl.obolibrary.org/obo/HP_0007068	Inferior cerebellar vermis hypoplasia	http://purl.obolibrary.org/obo/HP_0001320	Cerebellar vermis hypoplasia		Underdevelopment of the inferior portion of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0007074	Thick corpus callosum	http://purl.obolibrary.org/obo/HP_0001273	Abnormal corpus callosum morphology		Increased vertical dimension of the corpus callosum. This feature can be visualized by sagittal sections on magnetic resonance tomography imaging of the brain.
http://purl.obolibrary.org/obo/HP_0007076	Extrapyramidal muscular rigidity	http://purl.obolibrary.org/obo/HP_0002063	Rigidity		Muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).
http://purl.obolibrary.org/obo/HP_0007078	Decreased amplitude of sensory action potentials	http://purl.obolibrary.org/obo/HP_0030179	Abnormal peripheral action potential amplitude		A reduction in the amplitude of sensory nerve action potential. This feature is measured by nerve conduction studies.
http://purl.obolibrary.org/obo/HP_0007082	Dilated third ventricle	http://purl.obolibrary.org/obo/HP_0010951	Abnormal third ventricle morphology		An increase in size of the third ventricle.
http://purl.obolibrary.org/obo/HP_0007089	Facial-lingual fasciculations	http://purl.obolibrary.org/obo/HP_0010546	Muscle fibrillation		Fasciculations affecting the tongue muscle and the musculature of the face.
http://purl.obolibrary.org/obo/HP_0007098	Paroxysmal choreoathetosis	http://purl.obolibrary.org/obo/HP_0001266	Choreoathetosis		Episodes of choreoathetosis that can occur following triggers such as quick voluntary movements.
http://purl.obolibrary.org/obo/HP_0007099	Chiari type I malformation	http://purl.obolibrary.org/obo/HP_0002308	Chiari malformation		Arnold-Chiari type I malformation refers to a relatively mild degree of herniation of the posteroinferior region of the cerebellum (the cerebellar tonsils) into the cervical canal with little or no displacement of the fourth ventricle. It is characterized by one or both pointed (not rounded) cerebellar tonsils that project 5 mm below the foramen magnum, measured by a line drawn from the basion to the opisthion (McRae Line)
http://purl.obolibrary.org/obo/HP_0007103	Hypointensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		A darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter.
http://purl.obolibrary.org/obo/HP_0007105	Infantile encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		Encephalopathy with onset in the infantile period.
http://purl.obolibrary.org/obo/HP_0007107	Segmental peripheral demyelination	http://purl.obolibrary.org/obo/HP_0011096	Peripheral demyelination		A loss of myelin from the internode regions along myelinated nerve fibers from segments of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0007108	Demyelinating peripheral neuropathy	http://purl.obolibrary.org/obo/HP_0012447	Abnormal myelination		Demyelinating neuropathy is characterized by slow nerve conduction velocities with reduced amplitudes of sensory/motor nerve conduction and prolonged distal latencies.
http://purl.obolibrary.org/obo/HP_0007112	Temporal cortical atrophy	http://purl.obolibrary.org/obo/HP_0002120	Cerebral cortical atrophy		Atrophy of the temporal cortex.
http://purl.obolibrary.org/obo/HP_0007115	Naso-orbital encephalocele	http://purl.obolibrary.org/obo/HP_0007330	Frontoethmoidal encephalocele		A type of encephalocele that occurs along the medial orbit wall at the level of the frontal process of the maxilla and the ethmoid-lacrimal bone junction.
http://purl.obolibrary.org/obo/HP_0007123	Subcortical dementia	http://purl.obolibrary.org/obo/HP_0000726	Dementia		A particular type of dementia characterized by a pattern of mental defects consisting prominently of forgetfulness, slowness of thought processes, and personality or mood change.
http://purl.obolibrary.org/obo/HP_0007126	Proximal amyotrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Amyotrophy (muscular atrophy) affecting the proximal musculature.
http://purl.obolibrary.org/obo/HP_0007131	Acute demyelinating polyneuropathy	http://purl.obolibrary.org/obo/HP_0007108	Demyelinating peripheral neuropathy		Acute progressive areflexic weakness and mild sensory changes resulting from myelin breakdown and axonal degeneration.
http://purl.obolibrary.org/obo/HP_0007132	Pallidal degeneration	http://purl.obolibrary.org/obo/HP_0012157	Subcortical cerebral atrophy		Neurodegeneration involving the globus pallidus,a part of the basal ganglia that is involved in the regulation of voluntary movement.
http://purl.obolibrary.org/obo/HP_0007149	Distal upper limb amyotrophy	http://purl.obolibrary.org/obo/HP_0009129	Upper limb amyotrophy		Muscular atrophy of distal arm muscles.
http://purl.obolibrary.org/obo/HP_0007156	Asymmetric limb muscle stiffness	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in an asymmetric pattern.
http://purl.obolibrary.org/obo/HP_0007158	Progressive extrapyramidal muscular rigidity	http://purl.obolibrary.org/obo/HP_0007076	Extrapyramidal muscular rigidity		A progressive degree of muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).
http://purl.obolibrary.org/obo/HP_0007159	Fluctuations in consciousness	http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness		Changes in one's level of awareness and responsiveness to their environment.
http://purl.obolibrary.org/obo/HP_0007162	Diffuse demyelination of the cerebral white matter	http://purl.obolibrary.org/obo/HP_0007305	CNS demyelination		A diffuse loss of myelin from nerve fibers in the central nervous system.
http://purl.obolibrary.org/obo/HP_0007165	Periventricular heterotopia	http://purl.obolibrary.org/obo/HP_0002282	Gray matter heterotopia		A form of gray matter heterotopia were the mislocalized gray matter is typically located periventricularly, also sometimes called subependymal heterotopia. Periventricular means beside the ventricles. This is by far the most common location for heterotopia. Subependymal heterotopia present in a wide array of variations. There can be a small single node or a large number of nodes, can exist on either or both sides of the brain at any point along the higher ventricle margins, can be small or large, single or multiple, and can form a small node or a large wavy or curved mass.
http://purl.obolibrary.org/obo/HP_0007166	Paroxysmal dyskinesia	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		Episodic bouts of involuntary movements with dystonic, choreic, ballistic movements, or a combination thereof. There is no loss of consciousness during the attacks.
http://purl.obolibrary.org/obo/HP_0007179	Absent smooth pursuit	http://purl.obolibrary.org/obo/HP_0007772	Impaired smooth pursuit		A complete lack of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion.
http://purl.obolibrary.org/obo/HP_0007182	Peripheral hypomyelination	http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination		Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0007183	Focal T2 hyperintense basal ganglia lesion	http://purl.obolibrary.org/obo/HP_0012751	Abnormal basal ganglia MRI signal intensity		A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hyperintensity affecting a particular region of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0007185	Loss of consciousness	http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness		Loss of awareness of oneself or one's surroundings, involving (i) a loss of normal motor control is evident as flaccidity or stiffness, either of which can be accompanied by jerking movements, and postural control is lost so that patients fall if they are in an upright position; (ii) normal responsiveness is lost; and (iii) the patient experiences amnesia for the event. Loss of consciousness my be transitory (e.g., syncope) or prolonged.
http://purl.obolibrary.org/obo/HP_0007187	Focal lissencephaly	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		A congenital absence of the convolutions of the cerebral cortex and a poorly formed sylvian fissure that affects a particular part of the cortex.
http://purl.obolibrary.org/obo/HP_0007188	Congenital facial diplegia	http://purl.obolibrary.org/obo/HP_0001349	Facial diplegia		Facial diplegia (that is, bilateral facial palsy) with congenital onset.
http://purl.obolibrary.org/obo/HP_0007193	Bilateral tonic-clonic seizure on awakening	http://purl.obolibrary.org/obo/HP_0002069	Bilateral tonic-clonic seizure		Bilateral tonic-clonic seizure of either generalized or focal onset occurring on or soon after wakening (typically within 90 minutes of waking, regardless of the time of day).
http://purl.obolibrary.org/obo/HP_0007200	Episodic hypersomnia	http://purl.obolibrary.org/obo/HP_0001262	Excessive daytime somnolence		Recurrent episodes of hypersomnia (sleeping 16 or more hours a day) over a period of days or weeks.
http://purl.obolibrary.org/obo/HP_0007201	Cerebral artery atherosclerosis	http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology		The formation of the formation of fibrofatty lesions in the wall of an artery located in the brain.
http://purl.obolibrary.org/obo/HP_0007206	Hemimegalencephaly	http://purl.obolibrary.org/obo/HP_0001355	Megalencephaly		Enlargement of all or parts of one cerebral hemisphere.
http://purl.obolibrary.org/obo/HP_0007207	Photosensitive tonic-clonic seizure	http://purl.obolibrary.org/obo/HP_0025190	Bilateral tonic-clonic seizure with generalized onset		Generalized-onset tonic-clonic seizures that are provoked by flashing or flickering light.
http://purl.obolibrary.org/obo/HP_0007208	Irregular myelin loops	http://purl.obolibrary.org/obo/HP_0030173	Peripheral hypermyelination		Presence of irregular redundant loops of focally folded myelin in a peripheral nerve.
http://purl.obolibrary.org/obo/HP_0007209	Facial paralysis	http://purl.obolibrary.org/obo/HP_0003470	Paralysis		Complete loss of ability to move facial muscles innervated by the facial nerve (i.e., the seventh cranial nerve).
http://purl.obolibrary.org/obo/HP_0007210	Lower limb amyotrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Muscular atrophy affecting the lower limb.
http://purl.obolibrary.org/obo/HP_0007215	Periodic hyperkalemic paralysis	http://purl.obolibrary.org/obo/HP_0003768	Periodic paralysis		Episodes of muscle weakness associated with elevated levels of potassium in the blood.
http://purl.obolibrary.org/obo/HP_0007220	Demyelinating motor neuropathy	http://purl.obolibrary.org/obo/HP_0007178	Motor polyneuropathy		Demyelination of peripheral motor nerves.
http://purl.obolibrary.org/obo/HP_0007229	Intracerebral periventricular calcifications	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		The presence of calcium deposition in the cerebral white matter surrounding the cerebral ventricles.
http://purl.obolibrary.org/obo/HP_0007230	Decreased distal sensory nerve action potential	http://purl.obolibrary.org/obo/HP_0007078	Decreased amplitude of sensory action potentials		A reduction in the amplitude of sensory nerve action potential in distal nerve segments. This feature is measured by nerve conduction studies.
http://purl.obolibrary.org/obo/HP_0007233	Clusters of axonal regeneration	http://purl.obolibrary.org/obo/HP_0003450	Axonal regeneration		Groups of small caliber axons in peripheral nerve biospies indicative of axonal regeneration.
http://purl.obolibrary.org/obo/HP_0007240	Progressive gait ataxia	http://purl.obolibrary.org/obo/HP_0002066	Gait ataxia		A type of gait ataxia displaying progression of clinical severity.
http://purl.obolibrary.org/obo/HP_0007250	Recurrent external ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000544	External ophthalmoplegia		Alternating and recurrent weakness of the external ocular muscles.
http://purl.obolibrary.org/obo/HP_0007258	Severe demyelination of the white matter	http://purl.obolibrary.org/obo/HP_0007305	CNS demyelination		A severe loss of myelin from nerve fibers in the central nervous system.
http://purl.obolibrary.org/obo/HP_0007260	Type II lissencephaly	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		A form of lissencephaly characterized by an uneven cortical surface with a so called 'cobblestone' appearace. There are no distinguishable cortical layers.
http://purl.obolibrary.org/obo/HP_0007262	Symmetric peripheral demyelination	http://purl.obolibrary.org/obo/HP_0011096	Peripheral demyelination		A symmetric loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0007263	Spinocerebellar atrophy	http://purl.obolibrary.org/obo/HP_0001272	Cerebellar atrophy		Atrophy affecting the cerebellum and the spinocerebellar tracts of the spinal cord.
http://purl.obolibrary.org/obo/HP_0007265	Absent mesencephalon	http://purl.obolibrary.org/obo/HP_0034258	Aplasia/Hypoplasia of the midbrain		Agenesis of the midbrain.
http://purl.obolibrary.org/obo/HP_0007266	Cerebral dysmyelination	http://purl.obolibrary.org/obo/HP_0011400	Abnormal CNS myelination		Defective structure and function of myelin sheaths of the white matter of the brain.
http://purl.obolibrary.org/obo/HP_0007267	Chronic axonal neuropathy	http://purl.obolibrary.org/obo/HP_0003477	Peripheral axonal neuropathy		An abnormality characterized by chronic impairment of the normal functioning of the axons.
http://purl.obolibrary.org/obo/HP_0007269	Spinal muscular atrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.
http://purl.obolibrary.org/obo/HP_0007270	Atypical absence seizure	http://purl.obolibrary.org/obo/HP_0002121	Generalized non-motor (absence) seizure		An atypical absence seizure is a type of generalized non-motor (absence) seizure characterized by interruption of ongoing activities and reduced responsiveness. In comparison to a typical absence seizure, changes in tone may be more pronounced, onset and/or cessation may be less abrupt, and the duration of the ictus and post-ictal recovery may be longer. Although not always available, an EEG often demonstrates slow (<3 Hz), irregular, generalized spike-wave activity.
http://purl.obolibrary.org/obo/HP_0007274	Recurrent bacterial meningitis	http://purl.obolibrary.org/obo/HP_5210217	Bacterial meningitis		An increased susceptibility to bacterial meningitis as manifested by a medical history of recurrent episodes of bacterial meningitis.
http://purl.obolibrary.org/obo/HP_0007281	Developmental stagnation	http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental abnormality		A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills.
http://purl.obolibrary.org/obo/HP_0007285	Facial palsy secondary to cranial hyperostosis	http://purl.obolibrary.org/obo/HP_0005465	Facial hyperostosis		Paralysis of the facial nerves on the basis of overgrowth of the cranial bones causing impingement upon the seventh cranial nerve.
http://purl.obolibrary.org/obo/HP_0007286	Horizontal jerk nystagmus	http://purl.obolibrary.org/obo/HP_0000666	Horizontal nystagmus		Nystagmus consisting of horizontal to-and-fro eye movements, in which the movement in one direction is faster than in the other.
http://purl.obolibrary.org/obo/HP_0007289	Limb fasciculations	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		Fasciculations affecting the musculature of the arms and legs.
http://purl.obolibrary.org/obo/HP_0007301	Oromotor apraxia	http://purl.obolibrary.org/obo/HP_0002186	Apraxia		Oral-motor apraxia is the inability to volitionally sequence oral movements of the speech structure for nonspeech tasks in the absence of neuromuscular deficits such as paralysis or muscle weakness. Oral-motor apraxia is diagnosed when, despite intact sensory motor function an individual is unable to use these effector systems under voluntary control.
http://purl.obolibrary.org/obo/HP_0007302	Bipolar affective disorder	http://purl.obolibrary.org/obo/HP_0025783	Diagnostic behavioral phenotype		Bipolar disorder is an illness of mood characterized by alternating episodes of elevated and depressed moods, which are interspersed with euthymic periods.
http://purl.obolibrary.org/obo/HP_0007307	Rapid neurologic deterioration	http://purl.obolibrary.org/obo/HP_0002344	Progressive neurologic deterioration		Loss of neurological function in a time frame that is considered relatively quick, for instance, loss of a develomental milestone or substantial exacerbation of neurological complications such as seizures or feeding difficulties within a few months.
http://purl.obolibrary.org/obo/HP_0007321	Deep white matter hypodensities	http://purl.obolibrary.org/obo/HP_0007103	Hypointensity of cerebral white matter on MRI		Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the deep cerebral white matter.
http://purl.obolibrary.org/obo/HP_0007325	Generalized dystonia	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		A type of dystonia that affects all or most of the body.
http://purl.obolibrary.org/obo/HP_0007328	Impaired pain sensation	http://purl.obolibrary.org/obo/HP_0010832	Abnormality of pain sensation		Reduced ability to perceive painful stimuli.
http://purl.obolibrary.org/obo/HP_0007330	Frontoethmoidal encephalocele	http://purl.obolibrary.org/obo/HP_0007035	Anterior encephalocele		A type of anterior encephalocele in which there is a protrusion of the contents of the skull through a breach at the point where the frontal and ethmoidal bones meet. Frontoethmoidal encephalocele can be divided further into three distinct categories: nasofrontal, nasoethmoidal, and nasoorbital.
http://purl.obolibrary.org/obo/HP_0007332	Focal hemifacial clonic seizure	http://purl.obolibrary.org/obo/HP_0002266	Focal clonic seizure		Focal seizure characterized at onset by clonic movements affecting half of the face.
http://purl.obolibrary.org/obo/HP_0007333	Hypoplasia of the frontal lobes	http://purl.obolibrary.org/obo/HP_0006872	Cerebral hypoplasia		Underdevelopment of the frontal lobe of the cerebrum.
http://purl.obolibrary.org/obo/HP_0007334	Bilateral tonic-clonic seizure with focal onset	http://purl.obolibrary.org/obo/HP_0002069	Bilateral tonic-clonic seizure		A bilateral tonic-clonic seizure with focal onset is a focal-onset seizure which progresses into a bilateral tonic-clonic phase.
http://purl.obolibrary.org/obo/HP_0007335	Recurrent encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		Recurrent episodes of brain dysfunction that may be triggered by factors such as metabolic disturbances or infections.
http://purl.obolibrary.org/obo/HP_0007338	Hypermetric saccades	http://purl.obolibrary.org/obo/HP_0000570	Abnormal saccadic eye movements		A saccade that overshoots the target with the dynamic saccade.
http://purl.obolibrary.org/obo/HP_0007340	Lower limb muscle weakness	http://purl.obolibrary.org/obo/HP_0003690	Limb muscle weakness		Weakness of the muscles of the legs.
http://purl.obolibrary.org/obo/HP_0007343	Abnormal morphology of the limbic system	http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology		Any structural anomaly of the limbic system, a set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex].
http://purl.obolibrary.org/obo/HP_0007350	Upper limb hyperreflexia	http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia		Increased intensity of the a reflex in the arm.
http://purl.obolibrary.org/obo/HP_0007351	Upper limb postural tremor	http://purl.obolibrary.org/obo/HP_0200085	Limb tremor		A type of tremors that is triggered by holding an arm in a fixed position.
http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology	http://purl.obolibrary.org/obo/HP_0011283	Abnormal metencephalon morphology		A structural abnormality of the pons.
http://purl.obolibrary.org/obo/HP_0007371	Corpus callosum atrophy	http://purl.obolibrary.org/obo/HP_0033725	Thin corpus callosum		The presence of atrophy (wasting) of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0007379	Neoplasm of the genitourinary tract	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the genitourinary system.
http://purl.obolibrary.org/obo/HP_0007380	Facial telangiectasia	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		Telangiectases (small dilated blood vessels) located near the surface of the skin of the face.
http://purl.obolibrary.org/obo/HP_0007385	Aplasia cutis congenita of scalp	http://purl.obolibrary.org/obo/HP_0001057	Aplasia cutis congenita		A developmental defect resulting in the congenital absence of skin on the scalp.
http://purl.obolibrary.org/obo/HP_0007387	Hypoplastic sweat glands	http://purl.obolibrary.org/obo/HP_0011135	Aplasia/Hypoplasia of the sweat glands		Underdevelopment of the sweat glands.
http://purl.obolibrary.org/obo/HP_0007395	Postnatal-onset ichthyosiform erythroderma	http://purl.obolibrary.org/obo/HP_0008064	Ichthyosis		A type of ichthyosiform erythroderma with postnatal onset.
http://purl.obolibrary.org/obo/HP_0007396	Early cutaneous photosensitivity	http://purl.obolibrary.org/obo/HP_0000992	Cutaneous photosensitivity		Photosensitivity of the skin occurring early in life.
http://purl.obolibrary.org/obo/HP_0007397	Axillary apocrine gland hypoplasia	http://purl.obolibrary.org/obo/HP_0011135	Aplasia/Hypoplasia of the sweat glands		Developmental hypoplasia of the apocrine sweat glands in the region of the axilla.
http://purl.obolibrary.org/obo/HP_0007401	Macular atrophy	http://purl.obolibrary.org/obo/HP_0000608	Macular degeneration		A nonspecific term denoting wasting, especially as a result of degeneration, of the retinal pigment epithelium (RPE) and neurosensory retinal cells in the macula.
http://purl.obolibrary.org/obo/HP_0007404	Nonepidermolytic palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		Abnormal thickening of the skin on the palms and soles charactersized by hyperkeratosis of the stratum corneum with no evidence of epidermolysis characteristic of epidermolytic hyperkeratosis.
http://purl.obolibrary.org/obo/HP_0007408	Tegumentary leishmaniasis susceptibility	http://purl.obolibrary.org/obo/HP_0005386	Recurrent protozoan infections		Increased susceptibility to infection by the protozan parasite of the genus Leishmania.
http://purl.obolibrary.org/obo/HP_0007410	Palmoplantar hyperhidrosis	http://purl.obolibrary.org/obo/HP_0006089	Palmar hyperhidrosis		An abnormally increased perspiration on palms and soles.
http://purl.obolibrary.org/obo/HP_0007413	Nevus flammeus of the forehead	http://purl.obolibrary.org/obo/HP_0001052	Nevus flammeus		Naevus flammeus localized in the skin of the forehead.
http://purl.obolibrary.org/obo/HP_0007417	Discoid lupus rash	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		Cutaneous lesion that develops as a dry, scaly, red patch that evolves to an indurated and hyperpigmented plaque with adherent scale. Scarring may result in central white patches (loss of pigmentation) and skin atrophy.
http://purl.obolibrary.org/obo/HP_0007418	Alopecia totalis	http://purl.obolibrary.org/obo/HP_0001596	Alopecia		Loss of all scalp hair.
http://purl.obolibrary.org/obo/HP_0007420	Spontaneous hematomas	http://purl.obolibrary.org/obo/HP_0001933	Subcutaneous hemorrhage		Spontaneous development of hematomas (hematoma) or bruises without significant trauma.
http://purl.obolibrary.org/obo/HP_0007421	Telangiectases of the cheeks	http://purl.obolibrary.org/obo/HP_0007380	Facial telangiectasia		Telangiectases (small dilated blood vessels) located near the surface of the skin of the cheeks.
http://purl.obolibrary.org/obo/HP_0007428	Telangiectasia of the oral mucosa	http://purl.obolibrary.org/obo/HP_0000228	Oral cavity telangiectasia		Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the oral mucosa.
http://purl.obolibrary.org/obo/HP_0007429	Few cafe-au-lait spots	http://purl.obolibrary.org/obo/HP_0000957	Cafe-au-lait spot		The presence of two to five cafe-au-lait macules.
http://purl.obolibrary.org/obo/HP_0007430	Generalized edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
http://purl.obolibrary.org/obo/HP_0007431	Congenital ichthyosiform erythroderma	http://purl.obolibrary.org/obo/HP_0008064	Ichthyosis		An ichthyosiform abnormality of the skin with congenital onset.
http://purl.obolibrary.org/obo/HP_0007434	Plaque-like facial hemangioma	http://purl.obolibrary.org/obo/HP_0000329	Facial hemangioma		Hemangioma is a benign tumor of the vascular endothelial cells. This term refers to facial hemangiomas that have a plaque-like morphology.
http://purl.obolibrary.org/obo/HP_0007437	Multiple cutaneous leiomyomas	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		The presence of multiple leiomyomas of the skin.
http://purl.obolibrary.org/obo/HP_0007443	Partial albinism	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin		Absence of melanin pigment in various areas, which is found at birth and is permanent. The lesions are known as leucoderma and are often found on the face, trunk, or limbs.
http://purl.obolibrary.org/obo/HP_0007446	Palmoplantar blistering	http://purl.obolibrary.org/obo/HP_0033800	Blistering by anatomical location		A type of blistering that affects the skin of the palms of the hands and the soles of the feet.
http://purl.obolibrary.org/obo/HP_0007447	Diffuse palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		Diffuse abnormal thickening of the skin on the palms and soles.
http://purl.obolibrary.org/obo/HP_0007451	Ipsilateral lack of facial sweating	http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology		Inability to sweat on the same side of the face that is affected by ptosis and miosis. This is a feature of Horner syndrome.
http://purl.obolibrary.org/obo/HP_0007453	Flexural lichenification	http://purl.obolibrary.org/obo/HP_0100725	Lichenification		Lichenification affecting primarily flexural areas of the skin.
http://purl.obolibrary.org/obo/HP_0007457	Prominent veins on trunk	http://purl.obolibrary.org/obo/HP_0001015	Prominent superficial veins		Prominent thoracic and abdominal veins.
http://purl.obolibrary.org/obo/HP_0007462	Bitot spots of the conjunctiva	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Keratinization of the bulbar conjunctiva near the limbus (corneoscleral junction), resulting in a raised spot.
http://purl.obolibrary.org/obo/HP_0007464	Sparse facial hair	http://purl.obolibrary.org/obo/HP_0008070	Sparse hair		Reduced number or density of facial hair.
http://purl.obolibrary.org/obo/HP_0007465	Honeycomb palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		Abnormal thickening of the skin on the palms and soles with an honeycomb pattern.
http://purl.obolibrary.org/obo/HP_0007468	Perifollicular hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		Increased amount of keratin (visible as white scales) surrounding hair follicles.
http://purl.obolibrary.org/obo/HP_0007469	Palmoplantar cutis gyrata	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		Cutis gyrata of palms and soles.
http://purl.obolibrary.org/obo/HP_0007470	Periarticular subcutaneous nodules	http://purl.obolibrary.org/obo/HP_0001482	Subcutaneous nodule		Subcutaneous nodules that are located in the vicinity of joints.
http://purl.obolibrary.org/obo/HP_0007475	Congenital bullous ichthyosiform erythroderma	http://purl.obolibrary.org/obo/HP_0007431	Congenital ichthyosiform erythroderma		An ichthyosiform abnormality of the skin that presents at birth or shortly thereafter with generalized erythema, blistering, erosions, and peeling. In the subsequent months, erythema and blistering improves but patients go on to develop hyperkeratotic scaling that is especially prominent along the joint flexures, neck, hands and feet.
http://purl.obolibrary.org/obo/HP_0007479	Congenital nonbullous ichthyosiform erythroderma	http://purl.obolibrary.org/obo/HP_0007431	Congenital ichthyosiform erythroderma		The term collodion baby applies to newborns who appear to have an extra layer of skin (known as a collodion membrane) that has a collodion-like quality. It is a descriptive term, not a specific diagnosis or disorder (as such, it is a syndrome). Affected babies are born in a collodion membrane, a shiny waxy outer layer to the skin. This is shed 10-14 days after birth, revealing the main symptom of the disease, extensive scaling of the skin caused by hyperkeratosis. With increasing age, the scaling tends to be concentrated around joints in areas such as the groin, the armpits, the inside of the elbow and the neck. The scales often tile the skin and may resemble fish scales.
http://purl.obolibrary.org/obo/HP_0007485	Absence of subcutaneous fat	http://purl.obolibrary.org/obo/HP_0008887	Adipose tissue loss		Lack of subcutaneous adipose tissue.
http://purl.obolibrary.org/obo/HP_0007489	Diffuse telangiectasia	http://purl.obolibrary.org/obo/HP_0001009	Telangiectasia		Telangiectases (small dilated blood vessels) with a diffuse localization.
http://purl.obolibrary.org/obo/HP_0007497	Focal friction-related palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		Hyperkeratosis affecting the palm of the hand and the sole of the foot in areas exposed to friction.
http://purl.obolibrary.org/obo/HP_0007500	Decreased number of sweat glands	http://purl.obolibrary.org/obo/HP_0000971	Abnormal sweat gland morphology		The presence of fewer than normal sweat glands.
http://purl.obolibrary.org/obo/HP_0007502	Follicular hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		A skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules resulting from closure of hair follicles with a white plug of sebum.
http://purl.obolibrary.org/obo/HP_0007508	Punctate palmar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0010765	Palmar hyperkeratosis		Tiny bumps of thickened skin (hyperkeratosis) on the palms of the hands.
http://purl.obolibrary.org/obo/HP_0007514	Edema of the dorsum of hands	http://purl.obolibrary.org/obo/HP_0000969	Edema		An abnormal accumulation of fluid beneath the skin on the back of the hands.
http://purl.obolibrary.org/obo/HP_0007516	Redundant skin on fingers	http://purl.obolibrary.org/obo/HP_0001582	Redundant skin		Loose and sagging skin of the fingers.
http://purl.obolibrary.org/obo/HP_0007517	Palmoplantar cutis laxa	http://purl.obolibrary.org/obo/HP_0007605	Excessive wrinkling of palmar skin		Loose, wrinkled skin of hands and feet.
http://purl.obolibrary.org/obo/HP_0007534	Congenital posterior occipital alopecia	http://purl.obolibrary.org/obo/HP_0011361	Congenital abnormal hair pattern		Loss of hair in the occipital region of the scalp with congenital onset.
http://purl.obolibrary.org/obo/HP_0007537	Severe photosensitivity	http://purl.obolibrary.org/obo/HP_0000992	Cutaneous photosensitivity		A severe degree of photosensitivity of the skin.
http://purl.obolibrary.org/obo/HP_0007541	Frontal cutaneous lipoma	http://purl.obolibrary.org/obo/HP_0012032	Lipoma		Presence of a cutaneous lipoma on the forehead.
http://purl.obolibrary.org/obo/HP_0007542	Absent pigmentation of the ventral chest	http://purl.obolibrary.org/obo/HP_0040007	Absent pigmentation of chest		Lack of skin pigmentation (coloring) of the anterior chest.
http://purl.obolibrary.org/obo/HP_0007544	Piebald skin depigmentation	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin		Congenital large depigmented (white) macule of irergular rhomboid shape. Piebald skin depigmentation generally presents with multiple such macules in the affected individual. There may be smaller (5-15mm), discrete, skin-colored and hyperpigmented macules interspersed within the depigmented macules.
http://purl.obolibrary.org/obo/HP_0007545	Congenital palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		Abnormal thickening of the skin on the palms and soles that is present at birth.
http://purl.obolibrary.org/obo/HP_0007565	Multiple cafe-au-lait spots	http://purl.obolibrary.org/obo/HP_0000957	Cafe-au-lait spot		The presence of six or more cafe-au-lait spots.
http://purl.obolibrary.org/obo/HP_0007569	Generalized seborrheic dermatitis	http://purl.obolibrary.org/obo/HP_0001051	Seborrheic dermatitis		Seborrheic dermatitis that is not localized to any one particular region.
http://purl.obolibrary.org/obo/HP_0007570	Hyperkeratosis lenticularis perstans	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		Hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease, is a keratinization abnormality characterized by small, asymptomatic erythematous papules that leave characteristic punctate bleeding when they become detached. The lesions generally occur symmetrically along the top of the foot and on the legs, appearing more rarely on the arms, forearms, palms, and soles, and even on the oral mucosa.
http://purl.obolibrary.org/obo/HP_0007573	Late onset atopic dermatitis	http://purl.obolibrary.org/obo/HP_0001047	Atopic dermatitis		A form of atopic dermatitis with onset in adulthood characterized by atopic red face, chronic lichenified eczema on the trunk, subacute or psoriasiform dermatitis.
http://purl.obolibrary.org/obo/HP_0007576	Palmar neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized in the palm of the hand.
http://purl.obolibrary.org/obo/HP_0007588	Reticular hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		Increased pigmentation of the skin with a netlike (reticular) pattern.
http://purl.obolibrary.org/obo/HP_0007589	Aplasia cutis congenita on trunk or limbs	http://purl.obolibrary.org/obo/HP_0001057	Aplasia cutis congenita		A developmental defect resulting in the congenital absence of skin on the trunk or the limbs.
http://purl.obolibrary.org/obo/HP_0007592	Aplasia/Hypoplasia of the eccrine sweat glands	http://purl.obolibrary.org/obo/HP_0011135	Aplasia/Hypoplasia of the sweat glands		Absence or developmental hypoplasia of the eccrine sweat glands.
http://purl.obolibrary.org/obo/HP_0007596	Painful subcutaneous lipomas	http://purl.obolibrary.org/obo/HP_0001031	Subcutaneous lipoma		The presence of multiple subcutaneous lipoma that cause pain.
http://purl.obolibrary.org/obo/HP_0007598	Bilateral single transverse palmar creases	http://purl.obolibrary.org/obo/HP_0000954	Single transverse palmar crease		The distal and proximal transverse palmar creases are merged into a single transverse palmar crease on both hands.
http://purl.obolibrary.org/obo/HP_0007609	Hypoproteinemic edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body because of decreased osmotic pressure of plasma (hypoproteinemia).
http://purl.obolibrary.org/obo/HP_0007616	Nevus flammeus nuchae	http://purl.obolibrary.org/obo/HP_0001052	Nevus flammeus		Naevus flammeus localized in the skin of the neck. This is one of the most common birthmarks and present in approximately 25% of all newborns.
http://purl.obolibrary.org/obo/HP_0007618	Subcutaneous calcification	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		Deposition of calcium salts in subcutaneous tissue (i.e., the the lowermost layer of the integument).
http://purl.obolibrary.org/obo/HP_0007620	Cutaneous leiomyoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		The presence of leiomyoma of the skin.
http://purl.obolibrary.org/obo/HP_0007626	Mandibular osteomyelitis	http://purl.obolibrary.org/obo/HP_0002754	Osteomyelitis		Osteomyelitis of the lower jaw.
http://purl.obolibrary.org/obo/HP_0007633	Bilateral microphthalmos	http://purl.obolibrary.org/obo/HP_0000568	Microphthalmia		A developmental anomaly characterized by abnormal smallness of both eyes.
http://purl.obolibrary.org/obo/HP_0007634	Nonarteritic anterior ischemic optic neuropathy	http://purl.obolibrary.org/obo/HP_0001138	Optic neuropathy		An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disk or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates.
http://purl.obolibrary.org/obo/HP_0007642	Early-onset non-progressive night blindness	http://purl.obolibrary.org/obo/HP_0000662	Nyctalopia		A usually nonprogressive (i.e., stationary) form of night blindness with early (presumed to be congenital) onset.
http://purl.obolibrary.org/obo/HP_0007643	Peripheral tractional retinal detachment	http://purl.obolibrary.org/obo/HP_0007917	Tractional retinal detachment		Tractional retinal detachment at the periphery of the retina.
http://purl.obolibrary.org/obo/HP_0007646	Absent lower eyelashes	http://purl.obolibrary.org/obo/HP_0000561	Absent eyelashes		Lack of eyelashes on the lower lid.
http://purl.obolibrary.org/obo/HP_0007647	Congenital extraocular muscle anomaly	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		Congenital abnormality of the extraocular muscles.
http://purl.obolibrary.org/obo/HP_0007648	Punctate cataract	http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract		A type of cataract with punctate opacities of the lens.
http://purl.obolibrary.org/obo/HP_0007649	Congenital hypertrophy of retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0011512	Fundus hyperpigmentation		Sharply demarcated, congenital hyperpigmentation of the retinal pigment epithelium. It can be solitary, clustered or multifocal, uni- or bilateral.
http://purl.obolibrary.org/obo/HP_0007656	Lacrimal gland aplasia	http://purl.obolibrary.org/obo/HP_0008038	Aplastic/hypoplastic lacrimal glands		A congenital defect of development characterized by absence of the lacrimal gland.
http://purl.obolibrary.org/obo/HP_0007657	Diffuse nuclear cataract	http://purl.obolibrary.org/obo/HP_0100018	Nuclear cataract		Opacity of the entire lens nucleus.
http://purl.obolibrary.org/obo/HP_0007665	Curly eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		Abnormally curly or curved eyelashes.
http://purl.obolibrary.org/obo/HP_0007667	Peripheral cystoid retinal degeneration	http://purl.obolibrary.org/obo/HP_0007769	Peripheral retinal degeneration		Degenerative changes of the peripheral retina consisting of close-packed tiny cystic spaces at the outer plexiform/inner nuclear retinal level. The degeneration is common in adult eyes and starts adjacent to the ora serrata and extends circumferentially and posteriorly.
http://purl.obolibrary.org/obo/HP_0007670	Abnormal vestibulo-ocular reflex	http://purl.obolibrary.org/obo/HP_0001751	Abnormal vestibular function		An abnormality of the vestibulo-ocular reflex (VOR). The VOR attempts to keep the image stable on the retina. Ideally passive or active head movements in one direction are compensated for by eye movements of equal magnitude.
http://purl.obolibrary.org/obo/HP_0007677	Vitelliform macular lesion	http://purl.obolibrary.org/obo/HP_0030500	Yellow/white macular lesion		Egg yolk-like (vitelliform) maculopathy is a lesion caused by the accumulation of material, often lipofuscin, in the subretinal space underlying the macula. Lesions may be singular or multiple, and may be either sharply or poorly demarcated.
http://purl.obolibrary.org/obo/HP_0007678	Lacrimal duct stenosis	http://purl.obolibrary.org/obo/HP_0000579	Nasolacrimal duct obstruction		Narrowing of a tear duct (lacrimal duct).
http://purl.obolibrary.org/obo/HP_0007685	Avascular peripheral retina	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		Incomplete peripheral vascular development.
http://purl.obolibrary.org/obo/HP_0007686	Abnormal pupillary function	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		A functional abnormality of the pupil.
http://purl.obolibrary.org/obo/HP_0007687	Unilateral ptosis	http://purl.obolibrary.org/obo/HP_0000508	Ptosis		A unilateral form of ptosis.
http://purl.obolibrary.org/obo/HP_0007688	Undetectable light- and dark-adapted electroretinogram	http://purl.obolibrary.org/obo/HP_0008323	Abnormal light- and dark-adapted electroretinogram		Absence of the combined rod-and-cone response on electroretinogram.
http://purl.obolibrary.org/obo/HP_0007695	Abnormal pupillary light reflex	http://purl.obolibrary.org/obo/HP_0007686	Abnormal pupillary function		An abnormality of the reflex that controls the diameter of the pupil, in response to the intensity of light that falls on the retina of the eye.
http://purl.obolibrary.org/obo/HP_0007697	Hypoplasia of the lower eyelids	http://purl.obolibrary.org/obo/HP_0430009	Hypoplasia of eyelid		Underdevelopment of the lower eyelid.
http://purl.obolibrary.org/obo/HP_0007704	Paroxysmal involuntary eye movements	http://purl.obolibrary.org/obo/HP_0012547	Abnormal involuntary eye movements		Sudden-onset episode of abnormal, involuntary eye movements.
http://purl.obolibrary.org/obo/HP_0007707	Congenital aphakia	http://purl.obolibrary.org/obo/HP_6001302	Aphakia		Absence of the crystalline lens of the eye as a result of a developmental defect.
http://purl.obolibrary.org/obo/HP_0007709	Band-shaped corneal dystrophy	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		A type of genetically determined disease of the cornea with corneal lesions with a band-like shape.
http://purl.obolibrary.org/obo/HP_0007716	Uveal melanoma	http://purl.obolibrary.org/obo/HP_0100012	Neoplasm of the eye		A malignant melanoma originating within the eye. The tumor originates from the melanocytes in the uvea (which comprises the iris, ciliary body, and choroid).
http://purl.obolibrary.org/obo/HP_0007717	Chronic irritative conjunctivitis	http://purl.obolibrary.org/obo/HP_0000509	Conjunctivitis		A chronic irritative conjunctivitis, which commonly presents with general irritation and redness of the eyes, with a burning, dry, or foreign-body sensation of the eyes.
http://purl.obolibrary.org/obo/HP_0007720	Flat cornea	http://purl.obolibrary.org/obo/HP_0100691	Abnormality of the curvature of the cornea		Cornea plana is an abnormally flat shape of the cornea such that the normal protrusion of the cornea from the sclera is missing. The reduced corneal curvature can lead to hyperopia, and a hazy corneal limbus and arcus lipoides may develop at an early age.
http://purl.obolibrary.org/obo/HP_0007721	Saccular conjunctival dilatations	http://purl.obolibrary.org/obo/HP_0008054	Abnormal morphology of the conjunctival vasculature		Presence of multiple dilatations (sac-like outpouchings) in the blood vessels of the conjunctiva.
http://purl.obolibrary.org/obo/HP_0007722	Retinal pigment epithelial atrophy	http://purl.obolibrary.org/obo/HP_0001105	Retinal atrophy		A nonspecific term denoting wasting, especially as a result of degeneration, of the retinal pigment epithelium (RPE).
http://purl.obolibrary.org/obo/HP_0007727	Opacification of the corneal epithelium	http://purl.obolibrary.org/obo/HP_0007957	Corneal opacity		Lack of transparency of the corneal epithelium.
http://purl.obolibrary.org/obo/HP_0007728	Congenital miosis	http://purl.obolibrary.org/obo/HP_0000616	Miosis		Abnormal (non-physiological) constriction of the pupil of congenital onset.
http://purl.obolibrary.org/obo/HP_0007731	Chorioretinal dysplasia	http://purl.obolibrary.org/obo/HP_0000532	Abnormal chorioretinal morphology		Abnormal development of the choroid and retina.
http://purl.obolibrary.org/obo/HP_0007732	Lacrimal gland hypoplasia	http://purl.obolibrary.org/obo/HP_0008038	Aplastic/hypoplastic lacrimal glands		Underdevelopment of the lacrimal gland.
http://purl.obolibrary.org/obo/HP_0007734	Enlarged lacrimal glands	http://purl.obolibrary.org/obo/HP_0011482	Abnormal lacrimal gland morphology		Abnormally big lacrimal glands.
http://purl.obolibrary.org/obo/HP_0007737	Spicular pigmentation of the retina	http://purl.obolibrary.org/obo/HP_0000580	Pigmentary retinopathy		Pigment migration into the retina in a bone-spicule configuration (resembling the nucleated cells within the lacuna of bone).
http://purl.obolibrary.org/obo/HP_0007750	Hypoplasia of the fovea	http://purl.obolibrary.org/obo/HP_0008060	Aplasia/Hypoplasia of the fovea		Underdevelopment of the fovea centralis.
http://purl.obolibrary.org/obo/HP_0007754	Macular dystrophy	http://purl.obolibrary.org/obo/HP_0000556	Retinal dystrophy		Macular dystrophy is a nonspecific term for retinal degeneration, generally confined to the macula, usually presumed of genetic origin.
http://purl.obolibrary.org/obo/HP_0007761	Pericentral scotoma	http://purl.obolibrary.org/obo/HP_0000575	Scotoma		A scotoma (area of diminished vision within the visual field) that surrounds the central fixation point.
http://purl.obolibrary.org/obo/HP_0007763	Retinal telangiectasia	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		Localized, irregular dilatation of small tortuous intraretinal blood vessels.
http://purl.obolibrary.org/obo/HP_0007765	Deep anterior chamber	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		Increased depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is increased.
http://purl.obolibrary.org/obo/HP_0007766	Optic disc hypoplasia	http://purl.obolibrary.org/obo/HP_0008058	Aplasia/Hypoplasia of the optic nerve		Underdevelopment of the optic disc, that is of the optic nerve head, where ganglion cell axons exit the eye to form the optic nerve.
http://purl.obolibrary.org/obo/HP_0007768	Central retinal vessel vascular tortuosity	http://purl.obolibrary.org/obo/HP_0000631	Retinal arterial tortuosity		The presence of an increased number of twists and turns of retinal blood vessels (arteries, arterioles, veins, venules).
http://purl.obolibrary.org/obo/HP_0007769	Peripheral retinal degeneration	http://purl.obolibrary.org/obo/HP_0000546	Retinal degeneration		Progressive loss of peripheral retinal pigment epithelium (RPE) and/or neurosensory retinal cells.
http://purl.obolibrary.org/obo/HP_0007773	Vitreoretinopathy	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Ocular abnormality characterized by premature degeneration of the vitreous and the retina that may be associated with increased risk of retinal detachment.
http://purl.obolibrary.org/obo/HP_0007774	Hypoplasia of the ciliary body	http://purl.obolibrary.org/obo/HP_0008055	Aplasia/Hypoplasia affecting the uvea		Underdevelopment of the ciliary body.
http://purl.obolibrary.org/obo/HP_0007777	Chorioretinal scar	http://purl.obolibrary.org/obo/HP_0100699	Scarring		Fibrous connective tissue resulting from incomplete healing of a wound (i.e., a scar) located in the choroid and retina or the eye.
http://purl.obolibrary.org/obo/HP_0007778	Posterior retinal neovascularization	http://purl.obolibrary.org/obo/HP_0030666	Retinal neovascularization		A type of retinal neovascularization that affects the posterior pole of the retina.
http://purl.obolibrary.org/obo/HP_0007780	Cortical pulverulent cataract	http://purl.obolibrary.org/obo/HP_0010693	Pulverulent cataract		A type of cataract characterized by punctate, dust-like opacities within the cortical region of the lens.
http://purl.obolibrary.org/obo/HP_0007787	Posterior subcapsular cataract	http://purl.obolibrary.org/obo/HP_0000523	Subcapsular cataract		A type of cataract affecting the posterior pole of lens immediately adjacent to ('beneath') the Lens capsule.
http://purl.obolibrary.org/obo/HP_0007791	Patchy atrophy of the retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0007722	Retinal pigment epithelial atrophy		A nonspecific term denoting wasting, especially as a result of degeneration, of the retinal pigment epithelium (RPE) that occurs in small, isolated areas.
http://purl.obolibrary.org/obo/HP_0007793	Granular macular appearance	http://purl.obolibrary.org/obo/HP_0008002	Abnormal macular pigmentation		Mottled (spotted or blotched with different shades) pigmentary abnormality of the macula.
http://purl.obolibrary.org/obo/HP_0007795	Anterior cortical cataract	http://purl.obolibrary.org/obo/HP_0100019	Cortical cataract		A cataract that affects the anterior part of the cortex of the lens.
http://purl.obolibrary.org/obo/HP_0007797	Developmental retinal vascular malformation	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		A group of development abnormalities of retinal blood vessels.
http://purl.obolibrary.org/obo/HP_0007799	Conjunctival whitish salt-like deposits	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		The presence of whitish deposits in the conjunctiva resembling salt. May be related to calcinosis.
http://purl.obolibrary.org/obo/HP_0007800	Increased axial length of the globe	http://purl.obolibrary.org/obo/HP_0001090	Abnormally large globe		Abnormal largeness of the eye with an axial length > 2.5 standard deviations from population mean.
http://purl.obolibrary.org/obo/HP_0007802	Granular corneal dystrophy	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		The presence of central, fine, whitish granular lesions in the stroma of the cornea. This type of corneal dystrophy is usually asymptomatic and begins in childhood and shows a slow progression. Later in the course, the corneal epithelium and Bowman's layer may be affected. Histologically, the cornea shows a uniform deposition of hyaline material.
http://purl.obolibrary.org/obo/HP_0007803	Monochromacy	http://purl.obolibrary.org/obo/HP_0000551	Color vision defect		Complete color blindness, a complete inability to distinguish colors. Affected persons cannot perceive colors, but only shades of gray.
http://purl.obolibrary.org/obo/HP_0007811	Horizontal pendular nystagmus	http://purl.obolibrary.org/obo/HP_0012043	Pendular nystagmus		Nystagmus consisting of horizontal to-and-fro eye movements of equal velocity.
http://purl.obolibrary.org/obo/HP_0007812	Herpetiform corneal ulceration	http://purl.obolibrary.org/obo/HP_0012804	Corneal ulceration		The presence of one or more dendritic corneal epithelial ulcers characterized by a treelike branching linear pattern with feathery edges and terminal bulbs. Herpetiform corneal ulcers can be identified by fluorescein staining.
http://purl.obolibrary.org/obo/HP_0007813	Nongranulomatous uveitis	http://purl.obolibrary.org/obo/HP_0000554	Uveitis		A form of uveitis that is not associated with the formation of granulomas.
http://purl.obolibrary.org/obo/HP_0007814	Retinal pigment epithelial mottling	http://purl.obolibrary.org/obo/HP_0007703	Abnormal retinal pigmentation		Mottling (spots or blotches of different shades) of the retinal pigment epithelium, i.e., localized or generalized fundus pigment granularity associated with processes at the level of the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0007817	Horizontal supranuclear gaze palsy	http://purl.obolibrary.org/obo/HP_0000605	Supranuclear gaze palsy		A supranuclear gaze palsy is an inability to look in a horizontal direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal.
http://purl.obolibrary.org/obo/HP_0007818	Central heterochromia	http://purl.obolibrary.org/obo/HP_0001100	Heterochromia iridis		The presence of distinct colors in the central (pupillary) zone of the iris than in the mid-peripheral (ciliary) zone.
http://purl.obolibrary.org/obo/HP_0007819	Presenile cataracts	http://purl.obolibrary.org/obo/HP_0000518	Cataract		Presenile cataract is a kind of cataract that occurs in early adulthood, that is, at an age that is younger than usual.
http://purl.obolibrary.org/obo/HP_0007820	Lacrimal punctal atresia	http://purl.obolibrary.org/obo/HP_0011479	Abnormal lacrimal punctum morphology		Congenital absence or closure of the opening of the lacrimal punctum.
http://purl.obolibrary.org/obo/HP_0007824	Total ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000602	Ophthalmoplegia		Paralysis of both the extrinsic and intrinsic ocular muscles.
http://purl.obolibrary.org/obo/HP_0007830	Adult-onset night blindness	http://purl.obolibrary.org/obo/HP_0000662	Nyctalopia		Inability to see well at night or in poor light with onset in adulthood.
http://purl.obolibrary.org/obo/HP_0007831	Nonprogressive restrictive external ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000544	External ophthalmoplegia		Nonprogressive restriction of movement of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited.
http://purl.obolibrary.org/obo/HP_0007834	Progressive cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A kind of cataract that progresses with age.
http://purl.obolibrary.org/obo/HP_0007838	Progressive ptosis	http://purl.obolibrary.org/obo/HP_0000508	Ptosis		A progressive form of ptosis.
http://purl.obolibrary.org/obo/HP_0007840	Long upper eyelashes	http://purl.obolibrary.org/obo/HP_0000527	Long eyelashes		Increased length of the upper eyelashes.
http://purl.obolibrary.org/obo/HP_0007841	Amyloid deposition in the vitreous humor	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Deposition of hyaline extracellular material (amyloid) into the vitreous humor, which can manifest as vitreous opacities and reduced visual acuity.
http://purl.obolibrary.org/obo/HP_0007843	Attenuation of retinal blood vessels	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		Narrowing of the retinal blood vessels, both arterioles and venules.
http://purl.obolibrary.org/obo/HP_0007856	Punctate opacification of the cornea	http://purl.obolibrary.org/obo/HP_0007759	Opacification of the corneal stroma		Punctate opacification (reduced transparency) of the corneal stroma.
http://purl.obolibrary.org/obo/HP_0007859	Congenital horizontal nystagmus	http://purl.obolibrary.org/obo/HP_0006934	Congenital nystagmus		Horizontal nystagmus dating from or present at birth.
http://purl.obolibrary.org/obo/HP_0007862	Retinal calcification	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Deposition of calcium salts in the retina.
http://purl.obolibrary.org/obo/HP_0007867	Restrictive partial external ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0007936	Restrictive external ophthalmoplegia		Fibrosis of only some of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position.
http://purl.obolibrary.org/obo/HP_0007872	Choroidal hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		Benign choroidal tumour, seen in the fundus as a reddish or orange choroidal lesion and usually associated with cystoid edema, and less commonly with Subretinal fluid.
http://purl.obolibrary.org/obo/HP_0007874	Almond-shaped palpebral fissure	http://purl.obolibrary.org/obo/HP_0200005	Abnormal shape of the palpebral fissure		A shape created by an acute downward arching of the upper eyelid and upward arching of the lower eyelid, toward the medial canthus, which gives the outline of the palpebral fissures the configuration of an almond. Thus, the maximum distance between the fissures is offset from, and medial to, the center point.
http://purl.obolibrary.org/obo/HP_0007875	Congenital blindness	http://purl.obolibrary.org/obo/HP_0000618	Blindness		Blindness with onset at birth.
http://purl.obolibrary.org/obo/HP_0007879	Allergic conjunctivitis	http://purl.obolibrary.org/obo/HP_0000509	Conjunctivitis		Allergic Conjunctivitis is an allergic inflammation of the conjunctiva.
http://purl.obolibrary.org/obo/HP_0007885	Slowed horizontal saccades	http://purl.obolibrary.org/obo/HP_0000514	Slow saccadic eye movements		An abnormally slow velocity of horizontal saccadic eye movements.
http://purl.obolibrary.org/obo/HP_0007886	Absent extraocular muscles	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		Congenital absence of the extraocular muscles.
http://purl.obolibrary.org/obo/HP_0007889	Iridescent posterior subcapsular cataract	http://purl.obolibrary.org/obo/HP_0007787	Posterior subcapsular cataract		A type of posterior subcapsular cataract characterized by an iridescent color.
http://purl.obolibrary.org/obo/HP_0007892	Hypoplasia of the lacrimal punctum	http://purl.obolibrary.org/obo/HP_0011479	Abnormal lacrimal punctum morphology		Underdevelopment of the lacrimal puncta.
http://purl.obolibrary.org/obo/HP_0007894	Fundus hypopigmentation	http://purl.obolibrary.org/obo/HP_0031605	Abnormal fundus pigmentation		Generalized or focal reduced pigmentation of the fundus, evaluated in the context of skin and hair color. Fundoscopy may reveal a low level pigment.
http://purl.obolibrary.org/obo/HP_0007899	Retinal nonattachment	http://purl.obolibrary.org/obo/HP_0000541	Retinal detachment		Retinal nonattachment is a developmental (congenital) condition in which persistent fetal blood vessels appear to proliferate more dramatically during infancy, causing complete perinatal detachment of the retina. This may occur during or shortly after neurogenesis, since the pathology is apparent at birth, and it may have a tractional basis, involving fibrovascular strands between the retina, posterior lens and hyaloid vessels.
http://purl.obolibrary.org/obo/HP_0007902	Vitreous hemorrhage	http://purl.obolibrary.org/obo/HP_0011885	Hemorrhage of the eye		Bleeding within the vitreous compartment of the eye.
http://purl.obolibrary.org/obo/HP_0007903	Paravenous chorioretinal atrophy	http://purl.obolibrary.org/obo/HP_0000533	Chorioretinal atrophy		Chorioretinal atrophy along the retinal veins.
http://purl.obolibrary.org/obo/HP_0007906	Ocular hypertension	http://purl.obolibrary.org/obo/HP_0012633	Asymmetry of intraocular pressure		Intraocular pressure that is 2 standard deviations above the population mean.
http://purl.obolibrary.org/obo/HP_0007913	Reticular retinal dystrophy	http://purl.obolibrary.org/obo/HP_0007963	Pattern dystrophy of the retina		A type of of patterned retinal dystrophy that shows a reticular pattern of pigmentation.
http://purl.obolibrary.org/obo/HP_0007915	Polymorphous posterior corneal dystrophy	http://purl.obolibrary.org/obo/HP_0011491	Reduced number of corneal endothelial cells		This corneal dystrophy affects the posterior limiting membrane of the cornea and is characterized by polymorphous plaques of calcium deposits in the deep stromal layers of the cornea, and occasionally by vesicular lesions of the endothelium and edema of the deep corneal stroma.
http://purl.obolibrary.org/obo/HP_0007917	Tractional retinal detachment	http://purl.obolibrary.org/obo/HP_0000541	Retinal detachment		A type of retinal detachment arising due to a combination of contracting retinal membranes, abnormal vitreoretinal adhesions, and vitreous changes, in the absence of a full-thickness retinal defect.
http://purl.obolibrary.org/obo/HP_0007922	Hypermyelinated retinal nerve fibers	http://purl.obolibrary.org/obo/HP_0032028	Macular dots		Myelinated retinal nerve fiber (MRNF) layer is a rare and mostly benign congenital anomaly in which the retinal nerve fibers anterior to the lamina cribrosa have a myelin sheath.
http://purl.obolibrary.org/obo/HP_0007925	Lacrimal duct aplasia	http://purl.obolibrary.org/obo/HP_0011481	Abnormal lacrimal duct morphology		A congenital defect resulting in absence of the lacrimal duct.
http://purl.obolibrary.org/obo/HP_0007928	Abnormal flash visual evoked potentials	http://purl.obolibrary.org/obo/HP_0000649	Abnormality of visual evoked potentials		Anomaly of the visual evoked potentials elicited by a flash stimulus, generally a flash of light subtending an angle of at least 20 degrees of the visual field and presented in a dimly lit room.
http://purl.obolibrary.org/obo/HP_0007929	Peripheral retinal detachment	http://purl.obolibrary.org/obo/HP_0000541	Retinal detachment		Separation of the inner layers of the retina (neural retina) from the pigment epithelium occurring near the outer limit (periphery) of the retina.
http://purl.obolibrary.org/obo/HP_0007932	Bilateral congenital mydriasis	http://purl.obolibrary.org/obo/HP_0011499	Mydriasis		Congenital abnormal dilation of the pupil on both sides.
http://purl.obolibrary.org/obo/HP_0007933	Broad lateral eyebrow	http://purl.obolibrary.org/obo/HP_0011229	Broad eyebrow		Regional increase in the width (height) of the lateral eyebrow.
http://purl.obolibrary.org/obo/HP_0007936	Restrictive external ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000544	External ophthalmoplegia		Fibrosis of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited.
http://purl.obolibrary.org/obo/HP_0007937	Reticular pigmentary degeneration	http://purl.obolibrary.org/obo/HP_0011512	Fundus hyperpigmentation		A pattern of peripheral netlike retinal pigmentation that forms a polygonal arrangement of hyperpigmented lines forming geometric patterns in the fundus.
http://purl.obolibrary.org/obo/HP_0007939	Blue cone monochromacy	http://purl.obolibrary.org/obo/HP_0011517	Cone monochromacy		A form of monochromacy in which vision is derived from the remaining preserved blue (S) cones and rod photoreceptors.
http://purl.obolibrary.org/obo/HP_0007941	Limited extraocular movements	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Limited mobility of the eye within its socket.
http://purl.obolibrary.org/obo/HP_0007942	Internal ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000602	Ophthalmoplegia		Paralysis of the iris and ciliary apparatus.
http://purl.obolibrary.org/obo/HP_0007943	Congenital stapes ankylosis	http://purl.obolibrary.org/obo/HP_0000381	Stapes ankylosis		A form of stapes ankylosis with congenital onset.
http://purl.obolibrary.org/obo/HP_0007946	Unilateral narrow palpebral fissure	http://purl.obolibrary.org/obo/HP_0000581	Blepharophimosis		A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures on one side only.
http://purl.obolibrary.org/obo/HP_0007947	Pericentral retinitis pigmentosa	http://purl.obolibrary.org/obo/HP_0000510	Rod-cone dystrophy		A subtype of retinitis pigmentosa in which, instead of the pathology starting in the mid-periphery like typical retinitis pigmentosa, the disease starts in the near periphery closer to the vascular arcades and tends to spare the far periphery.
http://purl.obolibrary.org/obo/HP_0007948	Dense posterior cortical cataract	http://purl.obolibrary.org/obo/HP_0010924	Posterior cortical cataract		A type of posterior cortical cataract characterized by dense lenticular opacities.
http://purl.obolibrary.org/obo/HP_0007950	Peripapillary chorioretinal atrophy	http://purl.obolibrary.org/obo/HP_0000533	Chorioretinal atrophy		Chorioretinal atrophy concentrated around the optic papilla (i.e., the optic nerve head).
http://purl.obolibrary.org/obo/HP_0007963	Pattern dystrophy of the retina	http://purl.obolibrary.org/obo/HP_0007754	Macular dystrophy		A spectrum of fundoscopic appearances characterized by the development of a variety of patterns of deposits predominantly in the macular area. The deposits are typically bilateral, relatively symmetrical, yellow/white and associated with changes at the level of the retinal pigment epithelium. With time, retinal atrophy may occur. A number of pattern dystrophy subtypes have been described including butterfly-shaped dystrophy, reticular dystrophy (net-like pattern) and fundus pulverulentus (granular, mottled pigmentation).
http://purl.obolibrary.org/obo/HP_0007968	Remnants of the hyaloid vascular system	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disc to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth. This features results from a failure of regression of the hyaloid vessel, which supplies the primary vitreous during embryogenesis and normally regresses in the third trimester of pregnancy, leading to a particular form of posterior cataract.
http://purl.obolibrary.org/obo/HP_0007971	Lamellar cataract	http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract		A congenital cataract in which opacity is limited to layers of the lens external to the nucleus (i.e., the perinuclear region), i.e., between the nuclear and cortical layers of the lens.
http://purl.obolibrary.org/obo/HP_0007973	Retinal dysplasia	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Abnormal growth and differentiation, structure and appearance of the retina present from birth.
http://purl.obolibrary.org/obo/HP_0007975	Hypometric horizontal saccades	http://purl.obolibrary.org/obo/HP_0000571	Hypometric saccades		Saccadic undershoot of horizontal saccadic eye movements, i.e., a horizontal saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.
http://purl.obolibrary.org/obo/HP_0007976	Cerulean cataract	http://purl.obolibrary.org/obo/HP_0007648	Punctate cataract		Cerulean cataracts are a kind of congenital cataract having peripheral bluish and white opacifications in concentric layers with occasional central lesions arranged radially. Although the opacities may be observed during fetal development and childhood, usually visual acuity is only mildly reduced until adulthood, when lens extraction is generally necessary.
http://purl.obolibrary.org/obo/HP_0007979	Gaze-evoked horizontal nystagmus	http://purl.obolibrary.org/obo/HP_0000666	Horizontal nystagmus		Horizontal nystagmus made apparent by looking to the right or to the left.
http://purl.obolibrary.org/obo/HP_0007980	Absent retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0007894	Fundus hypopigmentation		Discrete areas of pallor in which the pigment epithelium, choriocapillaris and choroidal pigment are absent.
http://purl.obolibrary.org/obo/HP_0007984	ERG: Reduced dark-adapted b-wave amplitude	http://purl.obolibrary.org/obo/HP_0030478	Abnormal amplitude of dark-adapted bright flash electroretinogram		A dark-adapted bright flash electroretinogram in which the b-wave that is of markedly lower amplitude than the associated a-wave.
http://purl.obolibrary.org/obo/HP_0007985	Retinal arteriolar occlusion	http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology		Blockage of retinal arteriole, generally associated with interruption of blood flow and oxygen delivery to affected regions of the retina. This can affect the inner or mid-retinal structures.
http://purl.obolibrary.org/obo/HP_0007988	Macular hypopigmentation	http://purl.obolibrary.org/obo/HP_0008002	Abnormal macular pigmentation		Decreased amount of pigmentation in the macula.
http://purl.obolibrary.org/obo/HP_0007989	Intraretinal exudate	http://purl.obolibrary.org/obo/HP_0001147	Retinal exudate		Retinal exudate within the retinal tissue itself.
http://purl.obolibrary.org/obo/HP_0007990	Hypoplastic iris stroma	http://purl.obolibrary.org/obo/HP_0007676	Hypoplasia of the iris		Underdevelopment of the stroma of iris.
http://purl.obolibrary.org/obo/HP_0007992	Lattice retinal degeneration	http://purl.obolibrary.org/obo/HP_0007769	Peripheral retinal degeneration		A pattern of white lines and dots in the far periphery of the retina.
http://purl.obolibrary.org/obo/HP_0007993	Malformed lacrimal duct	http://purl.obolibrary.org/obo/HP_0011481	Abnormal lacrimal duct morphology		Congenital malformation of the lacrimal duct associated with incomplete development of the bony nasolacrimal canal or craniofacial anomalies.
http://purl.obolibrary.org/obo/HP_0007994	Peripheral visual field loss	http://purl.obolibrary.org/obo/HP_0001133	Constriction of peripheral visual field		Loss of peripheral vision with retention of central vision, resulting in a constricted circular tunnel-like field of vision.
http://purl.obolibrary.org/obo/HP_0008000	Decreased corneal reflex	http://purl.obolibrary.org/obo/HP_0034251	Abnormal corneal reflex		An abnormally reduced response to stimulation of the cornea (by touch, foreign body, blowing air). The corneal reflex (also known as the blink reflex, normally results in an involuntary blinking of the eyelids.
http://purl.obolibrary.org/obo/HP_0008001	Foveal hyperpigmentation	http://purl.obolibrary.org/obo/HP_0030493	Abnormal foveal pigmentation		Increased amount of pigmentation in the fovea.
http://purl.obolibrary.org/obo/HP_0008002	Abnormal macular pigmentation	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		Any deviation from the normal, uniform distribution or appearance of pigment within the macular region of the retina.
http://purl.obolibrary.org/obo/HP_0008019	Superior lens subluxation	http://purl.obolibrary.org/obo/HP_0001132	Lens subluxation		Partial dislocation of the lens in a superior direction.
http://purl.obolibrary.org/obo/HP_0008020	Cone dystrophy	http://purl.obolibrary.org/obo/HP_0000556	Retinal dystrophy		Inherited progressive cone degeneration.
http://purl.obolibrary.org/obo/HP_0008028	Cystoid macular degeneration	http://purl.obolibrary.org/obo/HP_0000608	Macular degeneration		A form of macular degeneration characterized by the presence of multiple cystoid spaces in the macula.
http://purl.obolibrary.org/obo/HP_0008031	Posterior Y-sutural cataract	http://purl.obolibrary.org/obo/HP_0010695	Sutural cataract		A type of sutural cataract in which the opacity follows the posterior Y suture.
http://purl.obolibrary.org/obo/HP_0008037	Absent anterior chamber of the eye	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		Absence of the anterior chamber of the eye owing to a developmental defect.
http://purl.obolibrary.org/obo/HP_0008038	Aplastic/hypoplastic lacrimal glands	http://purl.obolibrary.org/obo/HP_0011482	Abnormal lacrimal gland morphology		Absence or underdevelopment of the lacrimal gland.
http://purl.obolibrary.org/obo/HP_0008043	Focal retinal arteriolar constriction	http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology		Focal decreased retinal arteriolar diameters, which may decrease blood flow and slow oxygen delivery to regions of the retina.
http://purl.obolibrary.org/obo/HP_0008050	Abnormality of the palpebral fissures	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		An anomaly of the space between the medial and lateral canthi of the two open eyelids.
http://purl.obolibrary.org/obo/HP_0008060	Aplasia/Hypoplasia of the fovea	http://purl.obolibrary.org/obo/HP_0000493	Abnormal foveal morphology		Congenital absence or underdevelopment of the fovea.
http://purl.obolibrary.org/obo/HP_0008062	Aplasia/Hypoplasia affecting the anterior segment of the eye	http://purl.obolibrary.org/obo/HP_0008056	Aplasia/Hypoplasia affecting the eye		Absence or underdevelopment of the anterior segment of the eye.
http://purl.obolibrary.org/obo/HP_0008063	Aplasia/Hypoplasia of the lens	http://purl.obolibrary.org/obo/HP_0008062	Aplasia/Hypoplasia affecting the anterior segment of the eye		Absence or underdevelopment of the lens.
http://purl.obolibrary.org/obo/HP_0008064	Ichthyosis	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization.
http://purl.obolibrary.org/obo/HP_0008071	Maternal hypertension	http://purl.obolibrary.org/obo/HP_0100603	Toxemia of pregnancy		Increased blood pressure during a pregnancy.
http://purl.obolibrary.org/obo/HP_0008072	Maternal virilization in pregnancy	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum.
http://purl.obolibrary.org/obo/HP_0008073	Low maternal circulating estriol concentration	http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening		An abnormally low concentration of serum conjugated estriol as compared to normal values for gestational-age.
http://purl.obolibrary.org/obo/HP_0008076	Osteoporotic tarsals	http://purl.obolibrary.org/obo/HP_0009132	Abnormal tarsal bone mineral density		Reduction in bone mineral density affecting any or all of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.
http://purl.obolibrary.org/obo/HP_0008079	Absent fifth metatarsal	http://purl.obolibrary.org/obo/HP_0010744	Absent metatarsal bone		A developmental abnormality characterized by the absence of the fifth metatarsal bone.
http://purl.obolibrary.org/obo/HP_0008080	Hallux varus	http://purl.obolibrary.org/obo/HP_0010051	Deviation of the hallux		Medial deviation of the great toe owing to a deformity of the great toe joint causing the hallux to deviate medially.
http://purl.obolibrary.org/obo/HP_0008081	Pes valgus	http://purl.obolibrary.org/obo/HP_5210430	Hindfoot deformity		An outward (valgus) deviation of the calcaneus relative to the longitudinal axis of the lower leg at the talocalcaneal (subtalar) joint, such that the heel is everted.
http://purl.obolibrary.org/obo/HP_0008087	Nonossified fifth metatarsal	http://purl.obolibrary.org/obo/HP_0008371	Abnormal metatarsal ossification		The presence of a fifth metatarsal bone that has not undergone ossification at an age when ossification is usually visible.
http://purl.obolibrary.org/obo/HP_0008089	Abnormality of the fifth metatarsal bone	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		An anomaly of the fifth metatarsal bone.
http://purl.obolibrary.org/obo/HP_0008093	Short 4th toe	http://purl.obolibrary.org/obo/HP_0001831	Short toe		Underdevelopment (hypoplasia) of the fourth toe.
http://purl.obolibrary.org/obo/HP_0008094	Widely spaced toes	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		An overall widening of the spaces between the digits.
http://purl.obolibrary.org/obo/HP_0008095	Osteolysis of talus	http://purl.obolibrary.org/obo/HP_0009134	Osteolysis involving bones of the feet		Osteolysis affecting the talus.
http://purl.obolibrary.org/obo/HP_0008096	Medially deviated second toe	http://purl.obolibrary.org/obo/HP_0010326	Deviation of the 2nd toe		Medial deviation of the second toe.
http://purl.obolibrary.org/obo/HP_0008103	Delayed tarsal ossification	http://purl.obolibrary.org/obo/HP_0008369	Abnormal tarsal ossification		Delayed maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.
http://purl.obolibrary.org/obo/HP_0008107	Plantar crease between first and second toes	http://purl.obolibrary.org/obo/HP_0001869	Deep plantar creases		The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot located between the first and second toe.
http://purl.obolibrary.org/obo/HP_0008108	Advanced tarsal ossification	http://purl.obolibrary.org/obo/HP_0008369	Abnormal tarsal ossification		Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.
http://purl.obolibrary.org/obo/HP_0008112	Plantar flexion contracture	http://purl.obolibrary.org/obo/HP_0034677	Ankle contracture		A type of contracture in which the plantar flexion muscles are contracted.
http://purl.obolibrary.org/obo/HP_0008114	Metatarsal diaphyseal endosteal sclerosis	http://purl.obolibrary.org/obo/HP_0100925	Sclerosis of foot bone		Osteosclerosis of the endosteal surface of the diaphyses (shafts) of the metatarsal bones.
http://purl.obolibrary.org/obo/HP_0008115	Clinodactyly of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010332	Deviation of the 3rd toe		Bending or curvature of a third toe in the tibial direction (i.e., towards the big toe).
http://purl.obolibrary.org/obo/HP_0008116	Flexion limitation of toes	http://purl.obolibrary.org/obo/HP_0001436	Abnormality of the foot musculature		Limitation of the ability to bend the toes.
http://purl.obolibrary.org/obo/HP_0008122	Calcaneonavicular fusion	http://purl.obolibrary.org/obo/HP_0008368	Tarsal synostosis		Synostosis of the calcaneus with the navicular bone.
http://purl.obolibrary.org/obo/HP_0008124	Talipes calcaneovarus	http://purl.obolibrary.org/obo/HP_0001883	Talipes		A congenital deformity characterized by a dorsiflexed, inverted, and adducted foot, i.e., a combination of talipes calcaneus and talipes varus.
http://purl.obolibrary.org/obo/HP_0008127	Bipartite calcaneus	http://purl.obolibrary.org/obo/HP_0008364	Abnormality of the calcaneus		A two-part calcaneus, a finding that probably results from delayed coalescence of two primary calcaneal centers of ossification.
http://purl.obolibrary.org/obo/HP_0008131	Tarsal stippling	http://purl.obolibrary.org/obo/HP_0008369	Abnormal tarsal ossification		The presence of abnormal punctate (speckled, dot-like) calcifications in one or more tarsal bones.
http://purl.obolibrary.org/obo/HP_0008132	Medial rotation of the medial malleolus	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		Hindfoot valgus (posterior part of the foot turns outward) in combination with forefoot abduction (front part of the foot (the forefoot) is angled outwards away from the midline of the body, relative to the hindfoot) and lowering of the midfoot.
http://purl.obolibrary.org/obo/HP_0008134	Irregular tarsal ossification	http://purl.obolibrary.org/obo/HP_0008369	Abnormal tarsal ossification		Defective ossification in an irregular pattern of the seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.
http://purl.obolibrary.org/obo/HP_0008138	Equinus calcaneus	http://purl.obolibrary.org/obo/HP_5210430	Hindfoot deformity		Abnormal plantar flexion of the calcaneus relative to the longitudinal axis of the tibia. This results in the angle between the long axis of the tibia and the long axis of the heel bone (calcaneus) being greater than 90 degrees.
http://purl.obolibrary.org/obo/HP_0008142	Delayed calcaneal ossification	http://purl.obolibrary.org/obo/HP_0008103	Delayed tarsal ossification		Delayed maturation and calcification of the calcaneus.
http://purl.obolibrary.org/obo/HP_0008148	Impaired epinephrine-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to epinephrine as manifested by reduced or lacking aggregation of platelets upon addition of epinephrine.
http://purl.obolibrary.org/obo/HP_0008150	Elevated serum transaminases during infections	http://purl.obolibrary.org/obo/HP_0002910	Elevated circulating hepatic transaminase concentration		Elevations of the levels of SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) that occur during infections.
http://purl.obolibrary.org/obo/HP_0008151	Prolonged prothrombin time	http://purl.obolibrary.org/obo/HP_0032199	Abnormal prothrombin time		Increased time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.
http://purl.obolibrary.org/obo/HP_0008153	Periodic hypokalemic paresis	http://purl.obolibrary.org/obo/HP_0003768	Periodic paralysis		Episodes of muscle weakness associated with reduced levels of potassium in the blood.
http://purl.obolibrary.org/obo/HP_0008158	Hyperapobetalipoproteinemia	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein.
http://purl.obolibrary.org/obo/HP_0008160	3-hydroxydicarboxylic aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of 2-hydroxydicarboxylic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0008161	Absent leukocyte alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0004852	Reduced leukocyte alkaline phosphatase		Alkaline phosphatase levels measured within leukocytes is below detectable levels.
http://purl.obolibrary.org/obo/HP_0008162	Asymptomatic hyperammonemia	http://purl.obolibrary.org/obo/HP_0001987	Hyperammonemia		An increased concentration of ammonia in the blood not associated with symptoms such as encephalopathy.
http://purl.obolibrary.org/obo/HP_0008163	Decreased circulating cortisol level	http://purl.obolibrary.org/obo/HP_0011731	Abnormality of circulating cortisol level		Abnormally reduced concentration of cortisol in the blood.
http://purl.obolibrary.org/obo/HP_0008166	Decreased beta-galactosidase activity	http://purl.obolibrary.org/obo/HP_0004342	Abnormal galactosidase enyzme activity		Abnormally decreased rate of beta-galactosidase activity. Beta-galactosidase activity can be measured in leukocyte, fibroblast, or plasma.
http://purl.obolibrary.org/obo/HP_0008169	Reduced factor VII activity	http://purl.obolibrary.org/obo/HP_0010988	Abnormality of the extrinsic pathway		Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X.
http://purl.obolibrary.org/obo/HP_0008179	Decreased Arden ratio of electrooculogram	http://purl.obolibrary.org/obo/HP_0030454	Abnormal electrooculogram		An abnormal reduction in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record.
http://purl.obolibrary.org/obo/HP_0008181	Abetalipoproteinemia	http://purl.obolibrary.org/obo/HP_0003563	Decreased circulating LDL-C concentration		An absence of low-density lipoprotein cholesterol in the blood.
http://purl.obolibrary.org/obo/HP_0008185	Precocious puberty in males	http://purl.obolibrary.org/obo/HP_0000826	Precocious puberty		The onset of puberty before the age of 9 years in boys.
http://purl.obolibrary.org/obo/HP_0008186	Adrenocortical cytomegaly	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		The presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex.
http://purl.obolibrary.org/obo/HP_0008187	Absence of secondary sex characteristics	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		No secondary sexual characteristics are present at puberty.
http://purl.obolibrary.org/obo/HP_0008188	Thyroid dysgenesis	http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology		Thyroid dysgenesis is a descriptive term that should be avoided if more precise information is available. However, the HPO keeps retains this term because it is commonly used in the medical literature. In humans, the process of thyroid morphogenesis occurs from the 3rd to 16th week of gestation. Alterations occurring during this period may result in a thyroid gland that is absent (thyroid agenesis or athyreosis), hypoplastic (thyroid hypoplasia), or located in an unusual position (thyroid ectopy). All these entities are grouped under the term thyroid dysgenesis.
http://purl.obolibrary.org/obo/HP_0008189	Insulin insensitivity	http://purl.obolibrary.org/obo/HP_0011014	Abnormal glucose homeostasis		Decreased sensitivity toward insulin.
http://purl.obolibrary.org/obo/HP_0008191	Thyroid agenesis	http://purl.obolibrary.org/obo/HP_0033079	Aplasia/Hypoplasia of the thyroid gland		The congenital absence of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0008194	Multiple pancreatic beta-cell adenomas	http://purl.obolibrary.org/obo/HP_0008261	Pancreatic islet cell adenoma		The presence of multiple pancreatic islet cell adenomas.
http://purl.obolibrary.org/obo/HP_0008198	Congenital hypoparathyroidism	http://purl.obolibrary.org/obo/HP_0000829	Hypoparathyroidism		Deficiency of parathyroid hormone with congenital onset.
http://purl.obolibrary.org/obo/HP_0008200	Primary hyperparathyroidism	http://purl.obolibrary.org/obo/HP_0000843	Hyperparathyroidism		A type of hyperparathyroidism caused by a primary abnormality of the parathyroid glands (e.g., adenoma, carcinoma, hyperplasia). Primary hyperparathyroidism is associated with hyercalcemia.
http://purl.obolibrary.org/obo/HP_0008202	Reduced circulating prolactin concentration	http://purl.obolibrary.org/obo/HP_0040086	Abnormal prolactin level		A reduced level of prolactin in the blood circulation. Prolactin is a protein hormone that is secreted by lactotrophs in the anterior pituitary and that stimulates mammary gland development and milk production.
http://purl.obolibrary.org/obo/HP_0008205	Insulin-dependent but ketosis-resistant diabetes	http://purl.obolibrary.org/obo/HP_0005978	Type II diabetes mellitus		Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin.
http://purl.obolibrary.org/obo/HP_0008207	Primary adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0000846	Adrenal insufficiency		Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves.
http://purl.obolibrary.org/obo/HP_0008208	Parathyroid hyperplasia	http://purl.obolibrary.org/obo/HP_0011766	Abnormal parathyroid morphology		Hyperplasia of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0008209	Premature ovarian insufficiency	http://purl.obolibrary.org/obo/HP_0031066	Abnormal ovarian physiology		Amenorrhea due to loss of ovarian function before the age of 40. Primary ovarian insuficiency (POI) is a state of female hypergonadotropic hypogonadism. It can manifest as primary amenorrhea with onset before menarche or secondary amenorrhea.
http://purl.obolibrary.org/obo/HP_0008211	Parathyroid agenesis	http://purl.obolibrary.org/obo/HP_0011768	Parathyroid dysgenesis		Aplasia of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0008213	Gonadotropin deficiency	http://purl.obolibrary.org/obo/HP_0000830	Anterior hypopituitarism		A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH).
http://purl.obolibrary.org/obo/HP_0008214	Decreased serum estradiol	http://purl.obolibrary.org/obo/HP_0025133	Abnormal serum estradiol		A reduction below normal concentration of estradiol in the circulation.
http://purl.obolibrary.org/obo/HP_0008216	Adrenal gland dysgenesis	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Abnormal development of the adrenal gland.
http://purl.obolibrary.org/obo/HP_0008221	Adrenal hyperplasia	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Enlargement of the adrenal gland.
http://purl.obolibrary.org/obo/HP_0008223	Compensated hypothyroidism	http://purl.obolibrary.org/obo/HP_0000821	Hypothyroidism		Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4).
http://purl.obolibrary.org/obo/HP_0008226	Androgen insufficiency	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		Insufficient amount of androgenic activity.
http://purl.obolibrary.org/obo/HP_0008227	Pituitary resistance to thyroid hormone	http://purl.obolibrary.org/obo/HP_0011747	Abnormality of the anterior pituitary		A condition in which the pituitary gland is partially resistant to thyroid hormone, so that it continues to secrete thyroid-stimulating hormone (TSH) until the blood level of thyroid hormone rises higher than normal.
http://purl.obolibrary.org/obo/HP_0008229	Thyroid lymphangiectasia	http://purl.obolibrary.org/obo/HP_0031842	Lymphangiectasis		The presence of lymphangiectasis of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0008232	Elevated circulating follicle stimulating hormone level	http://purl.obolibrary.org/obo/HP_0030346	Abnormal circulating follicle-stimulating hormone concentration		An elevated concentration of follicle-stimulating hormone in the blood.
http://purl.obolibrary.org/obo/HP_0008233	Decreased circulating progesterone	http://purl.obolibrary.org/obo/HP_0031212	Abnormal circulating progesterone level		An reduced concentration of progesterone in the blood.
http://purl.obolibrary.org/obo/HP_0008237	Hypothalamic hypothyroidism	http://purl.obolibrary.org/obo/HP_0011787	Central hypothyroidism		A type of hypothyroidism that results from a defect in thyrotropin-releasing hormone activity.
http://purl.obolibrary.org/obo/HP_0008239	Adrenal medullary hypoplasia	http://purl.obolibrary.org/obo/HP_0000835	Adrenal hypoplasia		Developmental hypoplasia of the adrenal medulla.
http://purl.obolibrary.org/obo/HP_0008242	Pseudohypoaldosteronism	http://purl.obolibrary.org/obo/HP_0011733	Abnormality of adrenal physiology		A state of renal tubular unresponsiveness or resistance to the action of aldosterone.
http://purl.obolibrary.org/obo/HP_0008244	Congenital adrenal hypoplasia	http://purl.obolibrary.org/obo/HP_0000835	Adrenal hypoplasia		A type of adrenal hypoplasia with congenital onset.
http://purl.obolibrary.org/obo/HP_0008245	Pituitary hypothyroidism	http://purl.obolibrary.org/obo/HP_0011787	Central hypothyroidism		A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion.
http://purl.obolibrary.org/obo/HP_0008247	Euthyroid hyperthyroxinemia	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		Increased levels of thyroxine without evidence of clinical thyroid disease.
http://purl.obolibrary.org/obo/HP_0008249	Thyroid hyperplasia	http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology		Hyperplasia of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0008251	Congenital goiter	http://purl.obolibrary.org/obo/HP_0000853	Goiter		An enlargement of the thyroid gland with congenital onset.
http://purl.obolibrary.org/obo/HP_0008256	Adrenocortical adenoma	http://purl.obolibrary.org/obo/HP_0100641	Neoplasm of the adrenal cortex		Adrenocortical adenomas are benign tumors of the adrenal cortex.
http://purl.obolibrary.org/obo/HP_0008258	Congenital adrenal hyperplasia	http://purl.obolibrary.org/obo/HP_0008221	Adrenal hyperplasia		A type of adrenal hyperplasia with congenital onset.
http://purl.obolibrary.org/obo/HP_0008259	Adrenocorticotropin receptor defect	http://purl.obolibrary.org/obo/HP_0011734	Central adrenal insufficiency		Adrenal insufficiency secondary to a defect in the ACTH receptor.
http://purl.obolibrary.org/obo/HP_0008261	Pancreatic islet cell adenoma	http://purl.obolibrary.org/obo/HP_0006476	Abnormality of the pancreatic islet cells		The presence of an adenoma of the pancreas with origin in a pancreatic B cell.
http://purl.obolibrary.org/obo/HP_0008264	Neutrophil inclusion bodies	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neutrophils. Cytoplasmic neutrophil inclusions (oval, basophilic) are also known as Doehle bodies.
http://purl.obolibrary.org/obo/HP_0008271	Abnormal cartilage collagen	http://purl.obolibrary.org/obo/HP_0002763	Abnormal cartilage morphology		Abnormal morphology of collagen fibers in cartilage. In cartilage, collagen II, actually a collagen II:IX:XI heterofibril, is by far the most important type of collagen. A number of abnormalities may be appreciated by electron micrography or biochemical investigations, including sparse collagen fibers in the cartilage matrix.
http://purl.obolibrary.org/obo/HP_0008277	Abnormal circulating zinc concentration	http://purl.obolibrary.org/obo/HP_0011030	Abnormal circulating transition element cation concentration		Any deviation from the normal concentration of zinc in the blood circulation.
http://purl.obolibrary.org/obo/HP_0008278	Cerebellar cortical atrophy	http://purl.obolibrary.org/obo/HP_0001272	Cerebellar atrophy		Atrophy (wasting) of the cerebellar cortex.
http://purl.obolibrary.org/obo/HP_0008281	Acute hyperammonemia	http://purl.obolibrary.org/obo/HP_0001987	Hyperammonemia		An increased concentration of ammonia in the blood with sudden onset.
http://purl.obolibrary.org/obo/HP_0008282	Unconjugated hyperbilirubinemia	http://purl.obolibrary.org/obo/HP_0002904	Hyperbilirubinemia		An increased amount of unconjugated (indirect) bilurubin in the blood.
http://purl.obolibrary.org/obo/HP_0008283	Fasting hyperinsulinemia	http://purl.obolibrary.org/obo/HP_0000842	Hyperinsulinemia		An increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake.
http://purl.obolibrary.org/obo/HP_0008290	Partial complement factor H deficiency	http://purl.obolibrary.org/obo/HP_0005369	Decreased circulating complement factor H concentration		A partial reduction in level of the complement component Factor H in circulation.
http://purl.obolibrary.org/obo/HP_0008291	Pituitary corticotropic cell adenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A type of pituitary adenoma that produces adrenocorticotropic hormone (ACTH).
http://purl.obolibrary.org/obo/HP_0008293	Long-chain dicarboxylic aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		An increase in the level of long-chain dicarboxylic acid in the urine.
http://purl.obolibrary.org/obo/HP_0008297	Transient hyperphenylalaninemia	http://purl.obolibrary.org/obo/HP_0010893	Abnormal circulating phenylalanine concentration		A condition of not having consistently high levels of phenylalanine in the blood but of experiencing temporary hyperphenylalaninemia following ingestion of large quantities of phenylalanine (for instance, following an oral loading test with phenylalanine).
http://purl.obolibrary.org/obo/HP_0008301	Dermatan sulfate excretion in urine	http://purl.obolibrary.org/obo/HP_0008155	Mucopolysacchariduria		An increased concentration of dermatan sulfate in the urine.
http://purl.obolibrary.org/obo/HP_0008303	Olivary degeneration	http://purl.obolibrary.org/obo/HP_0011441	Abnormal medulla oblongata morphology		Degeneration of the olivary bodies, prominent oval structures in the medulla oblongata.
http://purl.obolibrary.org/obo/HP_0008305	Exercise-induced myoglobinuria	http://purl.obolibrary.org/obo/HP_0002913	Myoglobinuria		Presence of myoglobin in the urine following exercise.
http://purl.obolibrary.org/obo/HP_0008309	Medium chain dicarboxylic aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		An increase in the level of medium chain dicarboxylic acid in the urine.
http://purl.obolibrary.org/obo/HP_0008311	Spinal cord dorsal column hypomyelination	http://purl.obolibrary.org/obo/HP_0011397	Abnormal spinal cord dorsal column morphology		Lower than normal amount of myelin in the dorsal (posterior) tract of the spinal cord white matter.
http://purl.obolibrary.org/obo/HP_0008314	Decreased activity of mitochondrial complex II	http://purl.obolibrary.org/obo/HP_0008972	Decreased activity of mitochondrial respiratory chain		A reduction in the activity of the mitochondrial respiratory chain complex II, which is part of the electron transport chain in mitochondria.
http://purl.obolibrary.org/obo/HP_0008315	Decreased plasma free carnitine	http://purl.obolibrary.org/obo/HP_0003234	Decreased circulating carnitine concentration		A decreased concentration of free (unbound) carnitine in the blood.
http://purl.obolibrary.org/obo/HP_0008316	Abnormal mitochondria in muscle tissue	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		An abnormality of the mitochondria in muscle tissue.
http://purl.obolibrary.org/obo/HP_0008318	Elevated leukocyte alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003155	Elevated circulating alkaline phosphatase concentration		Increased alkaline phosphatase measured within leukocytes.
http://purl.obolibrary.org/obo/HP_0008320	Impaired collagen-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics.
http://purl.obolibrary.org/obo/HP_0008321	Reduced factor X activity	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa).
http://purl.obolibrary.org/obo/HP_0008322	Abnormal mitochondrial morphology	http://purl.obolibrary.org/obo/HP_0012103	Abnormality of the mitochondrion		Any structural anomaly of the mitochondria.
http://purl.obolibrary.org/obo/HP_0008323	Abnormal light- and dark-adapted electroretinogram	http://purl.obolibrary.org/obo/HP_0030466	Abnormal full-field electroretinogram		An abnormality of the combined rod-and-cone response on electroretinogram.
http://purl.obolibrary.org/obo/HP_0008326	Reduced circulating vitamin B6 circulating	http://purl.obolibrary.org/obo/HP_0032476	Abnormal circulating vitamin B6 concentration		An abnormally decreased concentration of vitamin B6 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0008327	Microscopic nephrocalcinosis	http://purl.obolibrary.org/obo/HP_0000121	Nephrocalcinosis		The presence of microscopic crystalline calcium precipitates in the form of oxalate and/or phosphate in the renal parenchyma.
http://purl.obolibrary.org/obo/HP_0008330	Reduced von Willebrand factor activity	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Decreased activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces.
http://purl.obolibrary.org/obo/HP_0008338	Partial functional complement factor D deficiency	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		A partial reduction in level of the complement component Factor D in circulation.
http://purl.obolibrary.org/obo/HP_0008339	Diaminoaciduria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An increased urine level of any amino acid carrying two amino groups (Asparagine, glutamine and lysine, cystine, ornithine).
http://purl.obolibrary.org/obo/HP_0008341	Distal renal tubular acidosis	http://purl.obolibrary.org/obo/HP_0001947	Renal tubular acidosis		A type of renal tubular acidosis characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of the distal nephron. The urine cannot be acidified below a pH of 5.3, associated with acidemia and hypokalemia.
http://purl.obolibrary.org/obo/HP_0008344	Elevated circulating branched chain amino acid concentration	http://purl.obolibrary.org/obo/HP_0010892	Abnormal circulating branched chain amino acid concentration		Concentration of a branched chain amino acid in the blood above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0008345	Hypoplasia of the iris dilator muscle	http://purl.obolibrary.org/obo/HP_0007676	Hypoplasia of the iris		Underdevelopment of the dilatator pupillae.
http://purl.obolibrary.org/obo/HP_0008347	Decreased activity of mitochondrial complex IV	http://purl.obolibrary.org/obo/HP_0008972	Decreased activity of mitochondrial respiratory chain		A reduction in the activity of the mitochondrial respiratory chain complex IV, which is part of the electron transport chain in mitochondria.
http://purl.obolibrary.org/obo/HP_0008348	Decreased circulating IgG2 concentration	http://purl.obolibrary.org/obo/HP_0032135	Decreased circulating IgG subclass concentration		A reduction in immunoglobulin levels of the IgG2 subclass in the blood circulation.
http://purl.obolibrary.org/obo/HP_0008352	Impaired platelet adhesion	http://purl.obolibrary.org/obo/HP_0011869	Abnormal platelet function		An abnormality of adhesion of thrombocytes. Normally, platelets adhere to collagen in the vascular subendothelium within seconds of injury via a receptor made up of glycoprotein Ia and IIa and GPVI and to vWF via receptor GPIb/IX/V. The adherent platelets then release granules that lead to platelet activation and aggregation.
http://purl.obolibrary.org/obo/HP_0008353	Neutral hyperaminoaciduria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		The presence of an abnormally increased concentration of neutral amino acids in the urine. The neutral amino acids are tryptophan, alanine, asparagine, glutamine, histidine, isoleucine, leucine, phenylalanine, serine, threonine, tyrosine and valine.
http://purl.obolibrary.org/obo/HP_0008354	Factor X activation deficiency	http://purl.obolibrary.org/obo/HP_0008321	Reduced factor X activity		Reduced ability to transform factor X into its activated form factor Xa.
http://purl.obolibrary.org/obo/HP_0008357	Reduced factor XIII activity	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Decreased activity of coagulation factor XIII (also known as fibrin stabilizing factor). Activated Factor XIII cross-links fibrin polymers solidifying the clot.
http://purl.obolibrary.org/obo/HP_0008358	Hyperprolinemia	http://purl.obolibrary.org/obo/HP_0010907	Abnormal circulating proline concentration		The concentration of proline in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0008360	Neonatal hypoproteinemia	http://purl.obolibrary.org/obo/HP_0003075	Hypoproteinemia		A neonatal decreased concentration of proteins in the blood.
http://purl.obolibrary.org/obo/HP_0008362	Aplasia/Hypoplasia of the hallux	http://purl.obolibrary.org/obo/HP_0010760	Absent toe		Absence or underdevelopment of the big toe.
http://purl.obolibrary.org/obo/HP_0008363	Aplasia/Hypoplasia of the tarsal bones	http://purl.obolibrary.org/obo/HP_0006494	Aplasia/Hypoplasia involving bones of the feet		Absence or underdevelopment of the tarsal bones.
http://purl.obolibrary.org/obo/HP_0008368	Tarsal synostosis	http://purl.obolibrary.org/obo/HP_0100266	Synostosis of carpals/tarsals		Synostosis (bony fusion) involving one or more bones of the tarsus (calcaneus, talus, cuboid, navicular, cuneiiform bones).
http://purl.obolibrary.org/obo/HP_0008369	Abnormal tarsal ossification	http://purl.obolibrary.org/obo/HP_0010675	Abnormal foot bone ossification		An abnormality of the formation and mineralization of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.
http://purl.obolibrary.org/obo/HP_0008371	Abnormal metatarsal ossification	http://purl.obolibrary.org/obo/HP_0010675	Abnormal foot bone ossification		Any abnormal process of ossification of the metatarsal bones, which normally are each ossified from two centers: one for the body, and one for the head (metatarsal II,III,IV, and V) and one for the body and one for the base (metatarsal I). The ossification process begins in the center of the body about the ninth week, and extends toward either extremity. The center for the base of the first metatarsal appears about the third year, and the centers for the heads of the other bones between the fifth and eighth years. They join the bodies between the eighteenth and twentieth years.
http://purl.obolibrary.org/obo/HP_0008372	Abnormal circulating vitamin A concentration	http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration		Concentration of vitamin A in the blood circulation outside limits of normal.
http://purl.obolibrary.org/obo/HP_0008383	Slow-growing nails	http://purl.obolibrary.org/obo/HP_0030807	Abnormal nail growth		Nails whose growth is slower than normal.
http://purl.obolibrary.org/obo/HP_0008390	Recurrent loss of toenails and fingernails	http://purl.obolibrary.org/obo/HP_0001806	Onycholysis		Repeated loss, or shedding, of the nails of the fingers and toes.
http://purl.obolibrary.org/obo/HP_0008391	Dystrophic fingernails	http://purl.obolibrary.org/obo/HP_0008404	Nail dystrophy		The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate.
http://purl.obolibrary.org/obo/HP_0008392	Subungual hyperkeratosis	http://purl.obolibrary.org/obo/HP_0009723	Abnormal subungual morphology		A thickening of the stratum corneum in the region beneath the nails.
http://purl.obolibrary.org/obo/HP_0008396	Chronic monilial nail infection	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Chronic infection of the nails by Candida species.
http://purl.obolibrary.org/obo/HP_0008398	Hypoplastic fifth fingernail	http://purl.obolibrary.org/obo/HP_0001804	Hypoplastic fingernail		A nail of the fifth finger that is diminished in length and width, i.e., underdeveloped nail of little finger.
http://purl.obolibrary.org/obo/HP_0008399	Circumungual hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		A thickening of the stratum corneum, the outer layer of the skin, in the region surrounding the nails.
http://purl.obolibrary.org/obo/HP_0008400	Onycholysis of distal fingernails	http://purl.obolibrary.org/obo/HP_0040039	Onycholysis of fingernails		Detachment of the distal fingernails from the nail bed.
http://purl.obolibrary.org/obo/HP_0008401	Onychogryphosis of toenails	http://purl.obolibrary.org/obo/HP_0001805	Onychogryphosis		Thickened toenails.
http://purl.obolibrary.org/obo/HP_0008402	Ridged fingernail	http://purl.obolibrary.org/obo/HP_0001807	Ridged nail		Longitudinal, linear prominences in the fingernail plate.
http://purl.obolibrary.org/obo/HP_0008417	Vertebral hypoplasia	http://purl.obolibrary.org/obo/HP_0008515	Aplasia/Hypoplasia of the vertebrae		Small, underdeveloped vertebral bodies.
http://purl.obolibrary.org/obo/HP_0008419	Intervertebral disk degeneration	http://purl.obolibrary.org/obo/HP_0005108	Abnormal intervertebral disk morphology		The presence of degenerative changes of intervertebral disk.
http://purl.obolibrary.org/obo/HP_0008420	Punctate vertebral calcifications	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		The presence of punctiform calcification of the bone of the vertebral bodies.
http://purl.obolibrary.org/obo/HP_0008422	Vertebral wedging	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		An abnormal shape of the vertebral bodies whereby the vertebral bodies are thick on one side and taper to a thin edge at the other.
http://purl.obolibrary.org/obo/HP_0008423	Spinal dysplasia	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		The presence of developmental dysplasia of the vertebral column.
http://purl.obolibrary.org/obo/HP_0008430	Anterior beaking of lumbar vertebrae	http://purl.obolibrary.org/obo/HP_0004568	Beaking of vertebral bodies		Anterior tongue-like protrusions of the vertebral bodies of the lumbar spine.
http://purl.obolibrary.org/obo/HP_0008432	Anterior wedging of L1	http://purl.obolibrary.org/obo/HP_0008422	Vertebral wedging		An abnormality of the shape of the lumbar vertebra L1 such that it is wedge-shaped (narrow towards the front).
http://purl.obolibrary.org/obo/HP_0008438	Vertebral arch anomaly	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		A morphological abnormality of the vertebral arch, i.e., of the posterior part of a vertebra.
http://purl.obolibrary.org/obo/HP_0008439	Lumbar hemivertebrae	http://purl.obolibrary.org/obo/HP_0002937	Hemivertebrae		Absence of one half of the vertebral body in the lumbar spine.
http://purl.obolibrary.org/obo/HP_0008441	Herniation of intervertebral nuclei	http://purl.obolibrary.org/obo/HP_0005108	Abnormal intervertebral disk morphology		The presence of one or more herniated nucleus pulposus of intervertebral disk.
http://purl.obolibrary.org/obo/HP_0008442	Vertebral hyperostosis	http://purl.obolibrary.org/obo/HP_0100774	Hyperostosis		Excessive growth of the bones of the vertebral bodies.
http://purl.obolibrary.org/obo/HP_0008443	Neuropathic spinal arthropathy	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		A progressive disorder of vertebral joint degeneration that occurs in the setting of any condition characterized by decreased afferent innervation, involving loss of deep pain and proprioceptive sensation in the vertebral column. Patients most commonly present with symptoms of lower back pain, sitting imbalance, progressive spinal deformity (usually kyphosis), and an audible clicking sound on changing postures.
http://purl.obolibrary.org/obo/HP_0008444	Posterior wedging of vertebral bodies	http://purl.obolibrary.org/obo/HP_0008422	Vertebral wedging		An abnormality of the shape of vertebrae, such that they are wedge-shaped (narrow towards the back).
http://purl.obolibrary.org/obo/HP_0008445	Cervical spinal canal stenosis	http://purl.obolibrary.org/obo/HP_0003416	Spinal canal stenosis		An abnormal narrowing of the cervical spinal canal.
http://purl.obolibrary.org/obo/HP_0008450	Narrow vertebral interpedicular distance	http://purl.obolibrary.org/obo/HP_0008438	Vertebral arch anomaly		A reduction of the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces.
http://purl.obolibrary.org/obo/HP_0008454	Lumbar kyphosis	http://purl.obolibrary.org/obo/HP_0100712	Abnormal lumbar spine morphology		Over curvature of the lumbar region.
http://purl.obolibrary.org/obo/HP_0008455	Dysplastic sacrum	http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology		A developmental defect of the sacrum characterized by partial or disordered development of the sacrum in which portions of the sacrum, which normally is formed by fusion of five sacral vertebrae S1-S5, fail to form or fail to form normally.
http://purl.obolibrary.org/obo/HP_0008456	C2-C3 subluxation	http://purl.obolibrary.org/obo/HP_0003308	Cervical subluxation		A partial dislocation of the intervertebral joint between the second and third cervical vertebrae.
http://purl.obolibrary.org/obo/HP_0008457	Caudal interpedicular narrowing	http://purl.obolibrary.org/obo/HP_0008450	Narrow vertebral interpedicular distance		Narrowing (becoming gradually narrower) of the distance between vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column. Note that normally, the interpedicular distances get progressively wider as one proceeds down the spine.
http://purl.obolibrary.org/obo/HP_0008458	Progressive congenital scoliosis	http://purl.obolibrary.org/obo/HP_0002650	Scoliosis		A progressive form of scoliosis with congenital onset.
http://purl.obolibrary.org/obo/HP_0008459	Cervical vertebral agenesis	http://purl.obolibrary.org/obo/HP_0011041	Aplasia/Hypoplasia of the cervical spine		Agenesis of one or more vertebrae of the cervical vertebral column.
http://purl.obolibrary.org/obo/HP_0008465	Absent vertebra	http://purl.obolibrary.org/obo/HP_0008515	Aplasia/Hypoplasia of the vertebrae		A developmental defect characterized by agenesis of one or more vertebral bodies.
http://purl.obolibrary.org/obo/HP_0008467	Thoracic hemivertebrae	http://purl.obolibrary.org/obo/HP_0002937	Hemivertebrae		Absence of one half of the vertebral body in the thoracic spine.
http://purl.obolibrary.org/obo/HP_0008468	Abnormal sacral segmentation	http://purl.obolibrary.org/obo/HP_0008490	Sacral segmentation defect		An abnormality related to a defect of vertebral separation of sacral vertebrae during development.
http://purl.obolibrary.org/obo/HP_0008469	Cervical vertebral dysplasia	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		Dysplasia of the cervical vertebral column.
http://purl.obolibrary.org/obo/HP_0008470	Lower thoracic interpediculate narrowness	http://purl.obolibrary.org/obo/HP_0008450	Narrow vertebral interpedicular distance		A reduction of the distance between the lower thoracic vertebral pedicles.
http://purl.obolibrary.org/obo/HP_0008473	Narrow anterio-posterior vertebral body diameter	http://purl.obolibrary.org/obo/HP_0008479	Hypoplastic vertebral bodies		An abnormal reduction of the anterioposterior diameter of the vertebral body.
http://purl.obolibrary.org/obo/HP_0008477	Poorly ossified cervical vertebrae	http://purl.obolibrary.org/obo/HP_0100856	Poorly ossified vertebrae		Decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set.
http://purl.obolibrary.org/obo/HP_0008480	Cervical spondylosis	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		Arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column.
http://purl.obolibrary.org/obo/HP_0008484	Thoracolumbar interpediculate narrowness	http://purl.obolibrary.org/obo/HP_0008450	Narrow vertebral interpedicular distance		A reduction of the distance between thoracolumbar vertebral pedicles.
http://purl.obolibrary.org/obo/HP_0008486	Lumbar interpedicular narrowing	http://purl.obolibrary.org/obo/HP_0008457	Caudal interpedicular narrowing		Narrowing (becoming gradually narrower) of the distance between lumbar vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column.
http://purl.obolibrary.org/obo/HP_0008489	Spondylolisthesis at L5-S1	http://purl.obolibrary.org/obo/HP_0003302	Spondylolisthesis		Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the fifth lumbar vertebral body (L5) onto the sacrum (level S1).
http://purl.obolibrary.org/obo/HP_0008491	Premature anterior fontanel closure	http://purl.obolibrary.org/obo/HP_0000236	Abnormal anterior fontanelle morphology		Early closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life.
http://purl.obolibrary.org/obo/HP_0008494	Inferior lens subluxation	http://purl.obolibrary.org/obo/HP_0001132	Lens subluxation		Partial displacement of the lens in the inferior direction.
http://purl.obolibrary.org/obo/HP_0008499	High hypermetropia	http://purl.obolibrary.org/obo/HP_0000540	Hypermetropia		A severe form of hypermetropia with over +5.00 diopters.
http://purl.obolibrary.org/obo/HP_0008504	Moderate sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0012713	Moderate hearing impairment		The presence of a moderate form of sensorineural hearing impairment.
http://purl.obolibrary.org/obo/HP_0008511	Central posterior corneal opacity	http://purl.obolibrary.org/obo/HP_0011493	Central opacification of the cornea		Reduced transparency of the central posterior portion of the corneal stroma.
http://purl.obolibrary.org/obo/HP_0008513	Bilateral conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0000405	Conductive hearing impairment		A bilateral type of conductive hearing impairment.
http://purl.obolibrary.org/obo/HP_0008517	Aplasia/Hypoplasia of the sacrum	http://purl.obolibrary.org/obo/HP_0008518	Aplasia/Hypoplasia involving the vertebral column		Aplasia or developmental hypoplasia of the sacral bone.
http://purl.obolibrary.org/obo/HP_0008523	Posterior helix pit	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Permanent indentation on the posteromedial aspect of the helix that may be sharply or indistinctly delineated.
http://purl.obolibrary.org/obo/HP_0008527	Congenital sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		A type of hearing impairment caused by an abnormal functionality of the cochlear nerve with congenital onset.
http://purl.obolibrary.org/obo/HP_0008529	Absence of acoustic reflex	http://purl.obolibrary.org/obo/HP_0040121	Abnormality of the acoustic reflex		Absence of the acoustic reflex, an involuntary contraction of the stapedius muscle that occurs in response to high-intensity sound stimuli.
http://purl.obolibrary.org/obo/HP_0008542	Low-frequency hearing loss	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A type of hearing impairment affecting primarily the low frequencies of sound (125 Hz to 1000 Hz).
http://purl.obolibrary.org/obo/HP_0008551	Microtia	http://purl.obolibrary.org/obo/HP_0008772	Aplasia/Hypoplasia of the external ear		Underdevelopment of the external ear.
http://purl.obolibrary.org/obo/HP_0008554	Cochlear malformation	http://purl.obolibrary.org/obo/HP_0000375	Abnormal cochlea morphology		The presence of a malformed cochlea.
http://purl.obolibrary.org/obo/HP_0008555	Absent vestibular function	http://purl.obolibrary.org/obo/HP_0001756	Vestibular hyporeflexia		Complete lack of functioning of the vestibular apparatus.
http://purl.obolibrary.org/obo/HP_0008568	Vestibular areflexia	http://purl.obolibrary.org/obo/HP_0007670	Abnormal vestibulo-ocular reflex		Vestibular areflexia can be measured as the absence of the caloric nystagmus response in electronystagmography.
http://purl.obolibrary.org/obo/HP_0008569	Microtia, second degree	http://purl.obolibrary.org/obo/HP_0008551	Microtia		Median longitudinal length of the ear more than two standard deviations below the mean in the presence of some, but not all, parts of the normal ear.
http://purl.obolibrary.org/obo/HP_0008573	Low-frequency sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		A form of sensorineural hearing impairment that affects primarily the lower frequencies.
http://purl.obolibrary.org/obo/HP_0008577	Underfolded helix	http://purl.obolibrary.org/obo/HP_0008544	Abnormally folded helix		Underdevelopment of the helix that either affects the entire helix, or is localized.
http://purl.obolibrary.org/obo/HP_0008583	Underfolded superior helices	http://purl.obolibrary.org/obo/HP_0008577	Underfolded helix		A condition in which the superior portion of the helix is folded over to a lesser degree than normal.
http://purl.obolibrary.org/obo/HP_0008586	Hypoplasia of the cochlea	http://purl.obolibrary.org/obo/HP_0011395	Aplasia/Hypoplasia of the cochlea		Developmental hypoplasia of the cochlea.
http://purl.obolibrary.org/obo/HP_0008587	Mild neurosensory hearing impairment	http://purl.obolibrary.org/obo/HP_0012712	Mild hearing impairment		The presence of a mild form of sensorineural hearing impairment.
http://purl.obolibrary.org/obo/HP_0008588	Slit-like opening of the exterior auditory meatus	http://purl.obolibrary.org/obo/HP_0000402	Stenosis of the external auditory canal		A type of stenosis of the external auditory meatus in which the opening of the external auditory meatus appears as a vertical slit.
http://purl.obolibrary.org/obo/HP_0008589	Hypoplastic helices	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Underdevelopment of the helix, i.e., of the outer rim of the pinna.
http://purl.obolibrary.org/obo/HP_0008591	Congenital conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0000405	Conductive hearing impairment		A type of conductive deafness with congenital onset.
http://purl.obolibrary.org/obo/HP_0008593	Prominent antitragus	http://purl.obolibrary.org/obo/HP_0009896	Abnormal antitragus morphology		Increased anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix.
http://purl.obolibrary.org/obo/HP_0008596	Postlingual sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0011474	Childhood onset sensorineural hearing impairment		A form of sensorineural hearing impairment with onset after the acquisition of speech.
http://purl.obolibrary.org/obo/HP_0008598	Mild conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0012712	Mild hearing impairment		A mild form of conductive hearing impairment.
http://purl.obolibrary.org/obo/HP_0008606	Supraauricular pit	http://purl.obolibrary.org/obo/HP_0100277	Periauricular skin pits		Benign congenital lesion of the supraauricular soft tissue consisting of a blind-ending narrow tube or pit.
http://purl.obolibrary.org/obo/HP_0008607	Progressive conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0000405	Conductive hearing impairment		A progressive type of conductive deafness.
http://purl.obolibrary.org/obo/HP_0008609	Abnormal middle ear morphology	http://purl.obolibrary.org/obo/HP_0000370	Abnormality of the middle ear		An abnormality of the morphology or structure of the middle ear.
http://purl.obolibrary.org/obo/HP_0008610	Infantile sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0011474	Childhood onset sensorineural hearing impairment		A form of sensorineural hearing impairment with infantile onset.
http://purl.obolibrary.org/obo/HP_0008615	Adult onset sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		The presence of sensorineural deafness with late onset.
http://purl.obolibrary.org/obo/HP_0008619	Bilateral sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		A form of sensorineural hearing impairment that affects both ears.
http://purl.obolibrary.org/obo/HP_0008625	Severe sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0012714	Severe hearing impairment		A severe form of sensorineural hearing impairment.
http://purl.obolibrary.org/obo/HP_0008631	Ureteral dysgenesis	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		A developmental anomaly of the ureter.
http://purl.obolibrary.org/obo/HP_0008633	Agonadism	http://purl.obolibrary.org/obo/HP_0000812	Abnormal internal genitalia		Absence of sex glands (gonads are the organs that produce gametes; testis in males and ovary in females).
http://purl.obolibrary.org/obo/HP_0008635	Urinary bladder wall hypertrophy	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Increase in thickness of the wall of the urinary bladder. This finding may be seen in conditions such as bladder outlet obstruction and may be accompanied by increased trabeculation of the bladder wall musculature.
http://purl.obolibrary.org/obo/HP_0008643	Nephroblastomatosis	http://purl.obolibrary.org/obo/HP_0011794	Embryonal renal neoplasm		Presence of persistent islands of renal blastema in the postnatal kidney. Nephroblastomatosis represents a complex abnormality of nephrogenesis and has been defined as the persistence of metanephricblastema into infancy and childhood.
http://purl.obolibrary.org/obo/HP_0008652	Autonomic erectile dysfunction	http://purl.obolibrary.org/obo/HP_0100639	Erectile dysfunction		Impotence (inability to develop or maintain an erection) resulting from abnormal functioning of the autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0008653	Crescentic glomerulonephritis	http://purl.obolibrary.org/obo/HP_0000099	Glomerulonephritis		A type of extracapillary glomerulonephritis characterized by the formation of crescent-like cellular proliferation.
http://purl.obolibrary.org/obo/HP_0008655	Aplasia/Hypoplasia of the fallopian tube	http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology		Aplasia or developmental hypoplasia of the fallopian tube.
http://purl.obolibrary.org/obo/HP_0008659	Multiple small medullary renal cysts	http://purl.obolibrary.org/obo/HP_0100957	Abnormal renal medulla morphology		The presence of many cysts in the medulla of the kidney.
http://purl.obolibrary.org/obo/HP_0008660	Renotubular dysgenesis	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		A developmental defect characterized by absence or poor development of proximal renal tubules.
http://purl.obolibrary.org/obo/HP_0008661	Urethral stenosis	http://purl.obolibrary.org/obo/HP_0000796	Urethral obstruction		Abnormal narrowing of the urethra.
http://purl.obolibrary.org/obo/HP_0008663	Renal sarcoma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		A sarcoma of the kidney.
http://purl.obolibrary.org/obo/HP_0008665	Clitoral hypertrophy	http://purl.obolibrary.org/obo/HP_0040253	Increased size of the clitoris		Hypertrophy of the clitoris.
http://purl.obolibrary.org/obo/HP_0008668	Gonadal dysgenesis, male	http://purl.obolibrary.org/obo/HP_0000133	Gonadal dysgenesis		Unusual gonadal development in a person with a 46,XY male karyotype, leading to an unassigned sex differentiation.
http://purl.obolibrary.org/obo/HP_0008672	Calcium oxalate nephrolithiasis	http://purl.obolibrary.org/obo/HP_0004724	Calcium nephrolithiasis		The presence of calcium- and oxalate-containing calculi (stones) in the kidneys.
http://purl.obolibrary.org/obo/HP_0008676	Congenital megaureter	http://purl.obolibrary.org/obo/HP_0000072	Hydroureter		A developmental disturbance with extreme ureteral dilatation.
http://purl.obolibrary.org/obo/HP_0008677	Congenital nephrotic syndrome	http://purl.obolibrary.org/obo/HP_0000100	Nephrotic syndrome		Nephrotic syndrome with onset within the first three months of life.
http://purl.obolibrary.org/obo/HP_0008682	Renal tubular epithelial necrosis	http://purl.obolibrary.org/obo/HP_0032618	Renal necrosis		Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%).
http://purl.obolibrary.org/obo/HP_0008683	Enlarged labia minora	http://purl.obolibrary.org/obo/HP_0012880	Abnormal labia minora morphology		Increase in size of the folds of skin between the outer labia.
http://purl.obolibrary.org/obo/HP_0008689	Bilateral cryptorchidism	http://purl.obolibrary.org/obo/HP_0000028	Cryptorchidism		Absence of both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum.
http://purl.obolibrary.org/obo/HP_0008691	Solitary bladder diverticulum	http://purl.obolibrary.org/obo/HP_0000015	Bladder diverticulum		Presence of a single diverticulum (sac or pouch) in the wall of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0008696	Renal hamartoma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		A disordered proliferation of mature tissues that are native to the kidneys.
http://purl.obolibrary.org/obo/HP_0008697	Hypoplasia of the fallopian tube	http://purl.obolibrary.org/obo/HP_0008655	Aplasia/Hypoplasia of the fallopian tube		Developmental hypoplasia of the fallopian tube.
http://purl.obolibrary.org/obo/HP_0008703	Gonadal calcification	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		Deposition of calcium salts in gonadal tissue.
http://purl.obolibrary.org/obo/HP_0008707	Absent scrotum	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Congenital absence of the scrotum.
http://purl.obolibrary.org/obo/HP_0008708	Partial development of the penile shaft	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		A congenital condition of the external male genitalia in which the shaft of the penis fails to fully develop.
http://purl.obolibrary.org/obo/HP_0008711	Benign prostatic hyperplasia	http://purl.obolibrary.org/obo/HP_0008775	Abnormal prostate morphology		The presence of non-malignant hyperplasia of the prostate.
http://purl.obolibrary.org/obo/HP_0008716	Urethrovaginal fistula	http://purl.obolibrary.org/obo/HP_0010480	Urethral fistula		The presence of a fistula between the vagina and the urethra.
http://purl.obolibrary.org/obo/HP_0008717	Unilateral renal atrophy	http://purl.obolibrary.org/obo/HP_0012585	Renal atrophy		A unilateral form of atrophy of the kidney.
http://purl.obolibrary.org/obo/HP_0008718	Unilateral renal dysplasia	http://purl.obolibrary.org/obo/HP_0000110	Renal dysplasia		A unilateral form of developmental dysplasia of the kidney.
http://purl.obolibrary.org/obo/HP_0008722	Urethral diverticulum	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		The presence of a diverticulum (sac or pouch) in the wall of the urethra.
http://purl.obolibrary.org/obo/HP_0008723	Gonadal dysgenesis with female appearance, male	http://purl.obolibrary.org/obo/HP_0000133	Gonadal dysgenesis		Unusual gonadal development in a person with a 46,XY male karyotype, leading to a more female sex differentiation.
http://purl.obolibrary.org/obo/HP_0008724	Hypoplasia of the ovary	http://purl.obolibrary.org/obo/HP_0010462	Aplasia/Hypoplasia of the ovary		Developmental hypoplasia of the ovary.
http://purl.obolibrary.org/obo/HP_0008726	Hypoplasia of the vagina	http://purl.obolibrary.org/obo/HP_0011026	Aplasia/Hypoplasia of the vagina		Developmental hypoplasia of the vagina.
http://purl.obolibrary.org/obo/HP_0008730	Female external genitalia in individual with 46,XY karyotype	http://purl.obolibrary.org/obo/HP_0000032	Abnormal male external genitalia morphology		The presence of female external genitalia in a person with a male karyotype.
http://purl.obolibrary.org/obo/HP_0008732	Renal hypophosphatemia	http://purl.obolibrary.org/obo/HP_0002148	Hypophosphatemia		Renal hypophosphatemia is defined as reduced serum phosphate (e.g., below 0.70 mmol/l) and an inappropriately high renal phosphate excretion.
http://purl.obolibrary.org/obo/HP_0008733	Dysplastic testis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		A descriptive term denoting a developmental anomaly of the male gonad characterized by architectural disorganization of the testicular parenchyma, which may include irregular or poorly formed seminiferous tubules, a thinned tunica albuginea, and increased or fibrotic interstitial tissue. Macroscopically, the testis may range from near-normal in size and appearance to a small, firm, or streak-like structure.
http://purl.obolibrary.org/obo/HP_0008738	Partially duplicated kidney	http://purl.obolibrary.org/obo/HP_0000075	Renal duplication		The presence of a partially duplicated kidney.
http://purl.obolibrary.org/obo/HP_0008740	Longitudinal vaginal septum	http://purl.obolibrary.org/obo/HP_0001153	Septate vagina		The presence of a longitudinal vaginal septum, thereby creating a vaginal duplication.
http://purl.obolibrary.org/obo/HP_0008743	Coronal hypospadias	http://purl.obolibrary.org/obo/HP_0003244	Penile hypospadias		A mild form of hypospadias in which the urethra opens just under the corona glandis, that is, where the head of the penis meets the shaft.
http://purl.obolibrary.org/obo/HP_0008744	Abnormal aryepiglottic fold morphology	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		An abnormality of the aryepiglottic fold.
http://purl.obolibrary.org/obo/HP_0008747	Cartilaginous ossification of larynx	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Ossification affecting the set of cartilages of larynx.
http://purl.obolibrary.org/obo/HP_0008749	Laryngeal hypoplasia	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Underdevelopment of the larynx.
http://purl.obolibrary.org/obo/HP_0008750	Laryngeal atresia	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Congenital absence of the lumen of the larynx. Laryngeal atresia is a rare condition. If the laryngeal opening fails to develop, fluid secreted by the lungs cannot be expelled. In a fetus with laryngeal atresia, the lungs are either normal or hyperplastic, not hypoplastic. Mortality is reported as 100%. At obstetric US examination, views of the fetal neck demonstrate a dilated trachea filled with trapped fluid. Views of the fetal chest show enlarged, hyperechoic lungs, with dilated fluid-filled bronchi. Fetal ascites is usually present.
http://purl.obolibrary.org/obo/HP_0008751	Laryngeal cleft	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esophagus.
http://purl.obolibrary.org/obo/HP_0008752	Laryngeal cartilage malformation	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		A malformation of the laryngeal cartilage.
http://purl.obolibrary.org/obo/HP_0008753	Aplasia of the epiglottis	http://purl.obolibrary.org/obo/HP_0010565	Aplasia/Hypoplasia of the Epiglottis		Absence of the epiglottis.
http://purl.obolibrary.org/obo/HP_0008754	Laryngeal calcification	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Calcification (abnormal deposits of calcium) in the laryngeal tissues.
http://purl.obolibrary.org/obo/HP_0008756	Bowing of the vocal cords	http://purl.obolibrary.org/obo/HP_0008777	Abnormal vocal cord morphology		Bowing (abnormal curvature) of the vocal folds.
http://purl.obolibrary.org/obo/HP_0008757	Unilateral vocal cord paralysis	http://purl.obolibrary.org/obo/HP_0001605	Vocal cord paralysis		A loss of the ability to move the vocal fold on one side.
http://purl.obolibrary.org/obo/HP_0008760	Violent behavior	http://purl.obolibrary.org/obo/HP_0000718	Aggressive behavior		Conduct and/or behavior, both verbal and non-verbal, including but not limited to verbal and/or physical aggression, attacks, threats, harassment, intimidation, and other disruptive behaviors in any form or through any medium, that cause or have the potential to cause a reasonable person to fear physical harm from any individual(s) or group(s) towards any person(s) or property. This is commonly defined as a violent act characterized by the use of physical force, anger, or sudden intense activity.
http://purl.obolibrary.org/obo/HP_0008763	No social interaction	http://purl.obolibrary.org/obo/HP_5200024	Abnormal relationship		Lack of intentional participation in interactions with another person.
http://purl.obolibrary.org/obo/HP_0008765	Auditory hallucination	http://purl.obolibrary.org/obo/HP_0000738	Hallucinations		Perception of sounds without auditory stimulus.
http://purl.obolibrary.org/obo/HP_0008767	Self-mutilation of tongue and lips due to involuntary movements	http://purl.obolibrary.org/obo/HP_0100716	Self-injurious behavior		Uncontrolled movements result in tissue damage to the tongue and lips.
http://purl.obolibrary.org/obo/HP_0008768	Abnormal sexual behavior	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		A deviation of sexual behaviors from the personal norms of the individual in the context of socially and culturally recognized patterns of human sexual behaviors.
http://purl.obolibrary.org/obo/HP_0008770	Obsessive-compulsive trait	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		The presence of one or more obsessive-compulsive personality traits. Obsessions refer to persistent intrusive thoughts, and compulsions to intrusive behaviors, which the affected person experiences as involuntary, senseless, or repugnant.
http://purl.obolibrary.org/obo/HP_0008771	Aplasia/Hypoplasia of the ear	http://purl.obolibrary.org/obo/HP_0031703	Abnormal ear morphology		The presence of aplasia or developmental hypoplasia of the ear.
http://purl.obolibrary.org/obo/HP_0008772	Aplasia/Hypoplasia of the external ear	http://purl.obolibrary.org/obo/HP_0008771	Aplasia/Hypoplasia of the ear		The presence of aplasia or developmental hypoplasia of all or part of the external ear.
http://purl.obolibrary.org/obo/HP_0008773	Aplasia/Hypoplasia of the middle ear	http://purl.obolibrary.org/obo/HP_0008771	Aplasia/Hypoplasia of the ear		Aplasia or developmental hypoplasia of all or part of the middle ear.
http://purl.obolibrary.org/obo/HP_0008774	Aplasia/Hypoplasia of the inner ear	http://purl.obolibrary.org/obo/HP_0008771	Aplasia/Hypoplasia of the ear		Aplasia or developmental hypoplasia of the inner ear.
http://purl.obolibrary.org/obo/HP_0008783	Wide proximal femoral metaphysis	http://purl.obolibrary.org/obo/HP_0006431	Abnormal proximal femoral metaphysis morphology		Increased width of the proximal part of the shaft (metaphysis) of the femur.
http://purl.obolibrary.org/obo/HP_0008784	Wide capital femoral epiphyses	http://purl.obolibrary.org/obo/HP_0010574	Abnormality of the epiphysis of the femoral head		Abnormally wide morphology of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0008785	Delayed ossification of pubic rami	http://purl.obolibrary.org/obo/HP_0009105	Abnormal ossification of the pubic bone		Delayed maturation and calcification of the rami (branches) of the pubic bone.
http://purl.obolibrary.org/obo/HP_0008786	Iliac crest serration	http://purl.obolibrary.org/obo/HP_0003796	Irregular iliac crest		Irregularities of the iliac crest that produce the appearance of a lace border around it.
http://purl.obolibrary.org/obo/HP_0008788	Delayed pubic bone ossification	http://purl.obolibrary.org/obo/HP_0009105	Abnormal ossification of the pubic bone		Delayed maturation and calcification of the pubic bone.
http://purl.obolibrary.org/obo/HP_0008789	Cone-shaped capital femoral epiphysis	http://purl.obolibrary.org/obo/HP_0010579	Cone-shaped epiphysis		A cone-shaped deformity of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0008794	Dysplastic iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		A general term that describes a congenital defect in the iliac wing resulting from abnormal development.
http://purl.obolibrary.org/obo/HP_0008796	Femoral retroversion	http://purl.obolibrary.org/obo/HP_0031069	Abnormal femoral torsion		An abnormal backward rotation of the hip relative to the knee such that the hips are externally rotated with the foot pointed outward instead of straight ahead (out-toeing).
http://purl.obolibrary.org/obo/HP_0008797	Early ossification of capital femoral epiphyses	http://purl.obolibrary.org/obo/HP_0009107	Abnormal ossification involving the femoral head and neck		Developmental acceleration of ossification of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0008798	Widened greater sciatic notch	http://purl.obolibrary.org/obo/HP_0010456	Abnormal greater sciatic notch morphology		The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a increase in the lateral dimension of the notch.
http://purl.obolibrary.org/obo/HP_0008801	Hypoplasia of the lesser trochanter	http://purl.obolibrary.org/obo/HP_0003366	Abnormal femoral neck/head morphology		Underdevelopment of the lesser trochanter.
http://purl.obolibrary.org/obo/HP_0008802	Hypoplasia of the femoral head	http://purl.obolibrary.org/obo/HP_0009108	Aplasia/Hypoplasia involving the femoral head and neck		Underdevelopment of the femoral head.
http://purl.obolibrary.org/obo/HP_0008804	Broad femoral head	http://purl.obolibrary.org/obo/HP_0003368	Abnormal femoral head morphology		Increased width of the femoral head.
http://purl.obolibrary.org/obo/HP_0008807	Acetabular dysplasia	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		A smaller than normal acetabulum that has insufficient femoral head coverage leading to abnormal hip joint contact pressures, instability and pain.
http://purl.obolibrary.org/obo/HP_0008808	High iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		Increased height of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally).
http://purl.obolibrary.org/obo/HP_0008812	Flattened femoral head	http://purl.obolibrary.org/obo/HP_0003368	Abnormal femoral head morphology		An abnormally flattened femoral head.
http://purl.obolibrary.org/obo/HP_0008817	Aplastic pubic bone	http://purl.obolibrary.org/obo/HP_0009104	Aplasia/Hypoplasia of the pubic bone		A developmental defect characterized by lack of development of the pubis bone.
http://purl.obolibrary.org/obo/HP_0008818	Large iliac wing	http://purl.obolibrary.org/obo/HP_0011867	Abnormal iliac wing morphology		Increased size of the ilium ala.
http://purl.obolibrary.org/obo/HP_0008819	Narrow femoral neck	http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology		An abnormally reduced diameter of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).
http://purl.obolibrary.org/obo/HP_0008820	Absent ossification of capital femoral epiphysis	http://purl.obolibrary.org/obo/HP_0009107	Abnormal ossification involving the femoral head and neck		Lack of ossification of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0008822	Hypoplastic ischiopubic ramus	http://purl.obolibrary.org/obo/HP_0003175	Hypoplastic ischia		Underdevelopment of the ischiopubic ramus, which is comprised of the inferior pubic ramus and the inferior ramus of the ischium.
http://purl.obolibrary.org/obo/HP_0008823	Inferior pubic ramus hypoplasia	http://purl.obolibrary.org/obo/HP_0008830	Hypoplastic pubic ramus		Underdevelopment of the lower branch of the pubis bone (inferior pubic ramus).
http://purl.obolibrary.org/obo/HP_0008824	Hypoplastic iliac body	http://purl.obolibrary.org/obo/HP_0000946	Hypoplastic ilia		Underdevelopment of the body of ilium.
http://purl.obolibrary.org/obo/HP_0008828	Delayed proximal femoral epiphyseal ossification	http://purl.obolibrary.org/obo/HP_0009107	Abnormal ossification involving the femoral head and neck		Developmental delay of ossification of the proximal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0008829	Delayed femoral head ossification	http://purl.obolibrary.org/obo/HP_0009107	Abnormal ossification involving the femoral head and neck		Delayed ossification of the femoral head.
http://purl.obolibrary.org/obo/HP_0008830	Hypoplastic pubic ramus	http://purl.obolibrary.org/obo/HP_0003173	Hypoplastic pubic bone		Underdevelopment of a ramus (branch) of the pubic bone.
http://purl.obolibrary.org/obo/HP_0008835	Multicentric femoral head ossification	http://purl.obolibrary.org/obo/HP_0009107	Abnormal ossification involving the femoral head and neck		There is normally one ossification center in the head of the femur. This term applies if there are multiple such centers.
http://purl.obolibrary.org/obo/HP_0008839	Hypoplastic pelvis	http://purl.obolibrary.org/obo/HP_0009103	Aplasia/Hypoplasia involving the pelvis		Underdevelopment of the bony pelvis.
http://purl.obolibrary.org/obo/HP_0008845	Mesomelic short stature	http://purl.obolibrary.org/obo/HP_0008873	Disproportionate short-limb short stature		A type of disproportionate short stature characterized by disproportionate shortening of the medial parts of the extremities (forearm or lower leg).
http://purl.obolibrary.org/obo/HP_0008846	Severe intrauterine growth retardation	http://purl.obolibrary.org/obo/HP_0001511	Intrauterine growth retardation		Intrauterine growth retardation that is 4 or more standard deviations below average, corrected for sex and gestational age.
http://purl.obolibrary.org/obo/HP_0008848	Moderately short stature	http://purl.obolibrary.org/obo/HP_0003508	Proportionate short stature		A moderate degree of short stature, more than -3 SD but not more than -4 SD from mean corrected for age and sex.
http://purl.obolibrary.org/obo/HP_0008850	Severe postnatal growth retardation	http://purl.obolibrary.org/obo/HP_0008897	Postnatal growth retardation		Severely slow or limited growth after birth, being four standard deviations or more below age- and sex-related norms.
http://purl.obolibrary.org/obo/HP_0008855	Moderate postnatal growth retardation	http://purl.obolibrary.org/obo/HP_0008897	Postnatal growth retardation		A moderate degree of slow or limited growth after birth, being between three and four standard deviations below age- and sex-related norms.
http://purl.obolibrary.org/obo/HP_0008857	Neonatal short-trunk short stature	http://purl.obolibrary.org/obo/HP_0003521	Disproportionate short-trunk short stature		A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with congenital onset recognizable at birth.
http://purl.obolibrary.org/obo/HP_0008866	Failure to thrive secondary to recurrent infections	http://purl.obolibrary.org/obo/HP_0001508	Failure to thrive		Insufficient weight gain or inappropriate weight loss for a child, that is attributed to an endogenous recurrent infections.
http://purl.obolibrary.org/obo/HP_0008883	Mild intrauterine growth retardation	http://purl.obolibrary.org/obo/HP_0001511	Intrauterine growth retardation		Intrauterine growth retardation that is at least 2 standard deviations (SD) below average, but not as low as 3 SD, corrected for sex and gestational age.
http://purl.obolibrary.org/obo/HP_0008915	Childhood-onset truncal obesity	http://purl.obolibrary.org/obo/HP_0001956	Truncal obesity		Truncal obesity with onset during childhood, defined as between 2 and 10 years of age.
http://purl.obolibrary.org/obo/HP_0008921	Neonatal short-limb short stature	http://purl.obolibrary.org/obo/HP_0008873	Disproportionate short-limb short stature		A type of short-limbed dwarfism that is manifest beginning in the neonatal period.
http://purl.obolibrary.org/obo/HP_0008922	Childhood-onset short-trunk short stature	http://purl.obolibrary.org/obo/HP_0003521	Disproportionate short-trunk short stature		A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in childhood.
http://purl.obolibrary.org/obo/HP_0008935	Generalized neonatal hypotonia	http://purl.obolibrary.org/obo/HP_0001319	Neonatal hypotonia		Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period and affecting the entire musculature.
http://purl.obolibrary.org/obo/HP_0008936	Axial hypotonia	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk.
http://purl.obolibrary.org/obo/HP_0008940	Generalized lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		A generalized form of lymphadenopathy.
http://purl.obolibrary.org/obo/HP_0008942	Acute rhabdomyolysis	http://purl.obolibrary.org/obo/HP_0003201	Rhabdomyolysis		An acute form of rhabdomyolysis.
http://purl.obolibrary.org/obo/HP_0008944	Distal lower limb amyotrophy	http://purl.obolibrary.org/obo/HP_0007210	Lower limb amyotrophy		Muscular atrophy of distal leg muscles.
http://purl.obolibrary.org/obo/HP_0008946	Pelvic girdle amyotrophy	http://purl.obolibrary.org/obo/HP_0003797	Limb-girdle muscle atrophy		Atrophy of the muscles of the pelvic girdle (also known as hip girdle), i.e., the gluteal muscles, the lateral rotators, the adductors, the psoas major and the iliacus muscle.
http://purl.obolibrary.org/obo/HP_0008947	Floppy infant	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		Floppiness/hypotonia is defined as reduced resistance to passive movement of joints. Physical examination of floppy/hypotonic infants shows head lag, lack of shoulder and elbow muscle contraction on traction response, inability to tighten the shoulder girdle muscles (or slipping through) when held under the axillae, scarf sign (when the arm is pulled to the opposite side, the arm wraps around the neck with the elbow crossing midline), hyperdorsiflexion of the feet, easy apposition of the thumb against the forearm, feet touching the cheek with ease and without discomfort, frog leg position, and inverted U sign on ventral suspension (head, arms, and legs hanging down without elbow or knee flexion and the trunk rounded in a dome shape).
http://purl.obolibrary.org/obo/HP_0008948	Proximal upper limb amyotrophy	http://purl.obolibrary.org/obo/HP_0007126	Proximal amyotrophy		Muscular atrophy affecting proximally located muscles of the arms.
http://purl.obolibrary.org/obo/HP_0008952	Shoulder muscle hypoplasia	http://purl.obolibrary.org/obo/HP_0009004	Hypoplasia of the musculature		Underdevelopment of muscles of the shoulder.
http://purl.obolibrary.org/obo/HP_0008953	Pectoralis major hypoplasia	http://purl.obolibrary.org/obo/HP_0011957	Abnormal pectoral muscle morphology		Underdevelopment of the pectoralis major.
http://purl.obolibrary.org/obo/HP_0008954	Intrinsic hand muscle atrophy	http://purl.obolibrary.org/obo/HP_0009130	Hand muscle atrophy		Atrophy of the intrinsic muscle groups of the hand, comprising the thenar and hypothenar muscles; the interossei muscles; and the lumbrical muscles.
http://purl.obolibrary.org/obo/HP_0008955	Progressive distal muscular atrophy	http://purl.obolibrary.org/obo/HP_0003693	Distal amyotrophy		Progressive muscular atrophy affecting muscles in the distal portions of the extremities.
http://purl.obolibrary.org/obo/HP_0008956	Proximal lower limb amyotrophy	http://purl.obolibrary.org/obo/HP_0007126	Proximal amyotrophy		Muscular atrophy affecting proximally located muscles of the legs, i.e., of the thigh.
http://purl.obolibrary.org/obo/HP_0008959	Distal upper limb muscle weakness	http://purl.obolibrary.org/obo/HP_0003484	Upper limb muscle weakness		Reduced strength of the distal musculature of the arms.
http://purl.obolibrary.org/obo/HP_0008962	Calf muscle hypoplasia	http://purl.obolibrary.org/obo/HP_0009004	Hypoplasia of the musculature		Underdevelopment of the muscuklature of the calf.
http://purl.obolibrary.org/obo/HP_0008963	Tibialis muscle weakness	http://purl.obolibrary.org/obo/HP_0009053	Distal lower limb muscle weakness		Muscle weakness affecting the tibialis anterior muscle.
http://purl.obolibrary.org/obo/HP_0008964	Nonprogressive muscular atrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Muscular atrophy that does not display a progression in severity with time.
http://purl.obolibrary.org/obo/HP_0008967	Exercise-induced muscle stiffness	http://purl.obolibrary.org/obo/HP_0003552	Muscle stiffness		A type of muscle stiffness that occurs following physical exertion.
http://purl.obolibrary.org/obo/HP_0008972	Decreased activity of mitochondrial respiratory chain	http://purl.obolibrary.org/obo/HP_0011922	Abnormal activity of mitochondrial respiratory chain		Decreased activity of the mitochondrial respiratory chain.
http://purl.obolibrary.org/obo/HP_0008981	Calf muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0008968	Muscle hypertrophy of the lower extremities		Muscle hypertrophy affecting the calf muscles.
http://purl.obolibrary.org/obo/HP_0008984	Neck muscle hypoplasia	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Underdevelopment of muscles of the neck.
http://purl.obolibrary.org/obo/HP_0008985	Increased intramuscular fat	http://purl.obolibrary.org/obo/HP_0009126	Increased adipose tissue		An abnormal increase in the amount of intramuscular fat tissue.
http://purl.obolibrary.org/obo/HP_0008986	Agenesis of the diaphragm	http://purl.obolibrary.org/obo/HP_0010315	Aplasia/Hypoplasia of the diaphragm		Congenital lack, i.e., aplasia of the diaphragm.
http://purl.obolibrary.org/obo/HP_0008991	Exercise-induced leg cramps	http://purl.obolibrary.org/obo/HP_0003710	Exercise-induced muscle cramps		Sudden and involuntary contractions of one or more muscles of the leg brought on by physical exertion.
http://purl.obolibrary.org/obo/HP_0008993	Increased intraabdominal fat	http://purl.obolibrary.org/obo/HP_0009126	Increased adipose tissue		An abnormal increase in the amount of intraabdominal fat tissue.
http://purl.obolibrary.org/obo/HP_0008997	Proximal upper limb muscle weakness	http://purl.obolibrary.org/obo/HP_0003701	Proximal muscle weakness		A lack of strength of the proximal muscles of the arms.
http://purl.obolibrary.org/obo/HP_0008998	Pectoralis hypoplasia	http://purl.obolibrary.org/obo/HP_0009004	Hypoplasia of the musculature		Underdevelopment of the pectoral muscle.
http://purl.obolibrary.org/obo/HP_0009002	Loss of truncal subcutaneous adipose tissue	http://purl.obolibrary.org/obo/HP_0008887	Adipose tissue loss		Loss (reduction of previously present) of subcutaneous adipose tissue in the region of the trunk.
http://purl.obolibrary.org/obo/HP_0009003	Increased subcutaneous truncal adipose tissue	http://purl.obolibrary.org/obo/HP_0009126	Increased adipose tissue		The presence of an abnormally increased amount of subcutaneous adipose tissue in the trunk of the body.
http://purl.obolibrary.org/obo/HP_0009004	Hypoplasia of the musculature	http://purl.obolibrary.org/obo/HP_0001460	Aplasia/Hypoplasia involving the skeletal musculature		Underdevelopment of the musculature.
http://purl.obolibrary.org/obo/HP_0009007	Biceps hypoplasia	http://purl.obolibrary.org/obo/HP_0009782	Aplasia/Hypoplasia of the biceps		Underdevelopment of the biceps muscle.
http://purl.obolibrary.org/obo/HP_0009011	Hypoplasia of serratus anterior muscle	http://purl.obolibrary.org/obo/HP_0009131	Abnormality of the musculature of the thorax		Underdevelopment of the serratus anterior muscle, which is involved in abduction, upward Rotation, and elevation of the scapula.
http://purl.obolibrary.org/obo/HP_0009016	Upper limb muscle hypoplasia	http://purl.obolibrary.org/obo/HP_0009004	Hypoplasia of the musculature		Underdevelopment of muscles of the arm.
http://purl.obolibrary.org/obo/HP_0009017	Loss of gluteal subcutaneous adipose tissue	http://purl.obolibrary.org/obo/HP_0008887	Adipose tissue loss		Loss (reduction of previously present) of subcutaneous adipose tissue in the gluteal region.
http://purl.obolibrary.org/obo/HP_0009020	Exercise-induced muscle fatigue	http://purl.obolibrary.org/obo/HP_0003750	Increased muscle fatiguability		An abnormally increased tendency towards muscle fatigue induced by physical exercise.
http://purl.obolibrary.org/obo/HP_0009023	Abdominal wall muscle weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Decreased strength of the abdominal musculature.
http://purl.obolibrary.org/obo/HP_0009025	Increased connective tissue	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		The presence of an abnormally increased amount of connective tissue.
http://purl.obolibrary.org/obo/HP_0009026	Hypoplasia of latissimus dorsi muscle	http://purl.obolibrary.org/obo/HP_0009131	Abnormality of the musculature of the thorax		Underdevelopment of the latissimus dorsi muscle, which is involved in adduction, extension, internal rotation, and transverse extension of the shoulder and assists in movement of the scapula.
http://purl.obolibrary.org/obo/HP_0009027	Foot dorsiflexor weakness	http://purl.obolibrary.org/obo/HP_0003690	Limb muscle weakness		Weakness of the muscles responsible for dorsiflexion of the foot, that is, of the movement of the toes towards the shin. The foot dorsiflexors include the tibialis anterior, the extensor hallucis longus, the extensor digitorum longus, and the peroneus tertius muscles.
http://purl.obolibrary.org/obo/HP_0009028	Generalized weakness of limb muscles	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		Generalized weakness of the muscles of the arms and legs.
http://purl.obolibrary.org/obo/HP_0009031	Amyotrophy of ankle musculature	http://purl.obolibrary.org/obo/HP_0001436	Abnormality of the foot musculature		Atrophy of the muscles of the ankle.
http://purl.obolibrary.org/obo/HP_0009045	Exercise-induced rhabdomyolysis	http://purl.obolibrary.org/obo/HP_0003201	Rhabdomyolysis		Rhabdomyolysis induced by exercise.
http://purl.obolibrary.org/obo/HP_0009046	Difficulty running	http://purl.obolibrary.org/obo/HP_0004302	Functional motor deficit		Reduced ability to run.
http://purl.obolibrary.org/obo/HP_0009049	Peroneal muscle atrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Atrophy of the peroneous muscles, peroneus longus (also known as Fibularis longus), Peroneus brevis (also known as fibularis brevis, and Peroneus tertius (also known as fibularis tertius).
http://purl.obolibrary.org/obo/HP_0009050	Quadriceps muscle atrophy	http://purl.obolibrary.org/obo/HP_0008956	Proximal lower limb amyotrophy		Muscular atrophy involving the quadriceps muscle.
http://purl.obolibrary.org/obo/HP_0009051	Increased muscle glycogen content	http://purl.obolibrary.org/obo/HP_0012269	Abnormal muscle glycogen content		An increased amount of glycogen in muscle tissue.
http://purl.obolibrary.org/obo/HP_0009053	Distal lower limb muscle weakness	http://purl.obolibrary.org/obo/HP_0007340	Lower limb muscle weakness		Reduced strength of the distal musculature of the legs.
http://purl.obolibrary.org/obo/HP_0009055	Generalized limb muscle atrophy	http://purl.obolibrary.org/obo/HP_0003700	Generalized amyotrophy		Generalized (unlocalized) atrophy affecting muscles of the limbs in both proximal and distal locations.
http://purl.obolibrary.org/obo/HP_0009058	Increased muscle lipid content	http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration		An abnormal accumulation of lipids in skeletal muscle.
http://purl.obolibrary.org/obo/HP_0009060	Scapular muscle atrophy	http://purl.obolibrary.org/obo/HP_0001465	Amyotrophy involving the shoulder musculature		Atrophy of the muscles that are responsible for moving the scapula, which are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle.
http://purl.obolibrary.org/obo/HP_0009063	Progressive distal muscle weakness	http://purl.obolibrary.org/obo/HP_0002460	Distal muscle weakness		Progressively reduced strength of the distal musculature.
http://purl.obolibrary.org/obo/HP_0009064	Generalized lipodystrophy	http://purl.obolibrary.org/obo/HP_0009125	Lipodystrophy		Generalized degenerative changes of the fat tissue.
http://purl.obolibrary.org/obo/HP_0009067	Progressive spinal muscular atrophy	http://purl.obolibrary.org/obo/HP_0007269	Spinal muscular atrophy		Progressive spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.
http://purl.obolibrary.org/obo/HP_0009071	Inflammatory myopathy	http://purl.obolibrary.org/obo/HP_0003198	Myopathy		Chronic muscle inflammation accompanied by muscle weakness.
http://purl.obolibrary.org/obo/HP_0009072	Decreased Achilles reflex	http://purl.obolibrary.org/obo/HP_0002600	Hyporeflexia of lower limbs		Decreased intensity of the Achilles reflex (also known as the ankle jerk reflex), which can be elicited by tapping the tendon is tapped while the foot is dorsiflexed.
http://purl.obolibrary.org/obo/HP_0009073	Progressive proximal muscle weakness	http://purl.obolibrary.org/obo/HP_0003701	Proximal muscle weakness		Lack of strength of the proximal muscles that becomes progressively more severe.
http://purl.obolibrary.org/obo/HP_0009085	Alveolar ridge overgrowth	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		Increased width of the alveolar ridges.
http://purl.obolibrary.org/obo/HP_0009088	Speech articulation difficulties	http://purl.obolibrary.org/obo/HP_0002463	Language impairment		Impairment in the physical production of speech sounds.
http://purl.obolibrary.org/obo/HP_0009098	Recurrent oral thrush	http://purl.obolibrary.org/obo/HP_5210252	Unusual oral thrush		Chronic accumulation and overgrowth of the fungus Candida albicans on the mucous membranes of the mouth, generally manifested as associated with creamy white lesions on the tongue or inner cheeks, occasionally spreading to the gums, tonsils, palate or oropharynx.
http://purl.obolibrary.org/obo/HP_0009099	Median cleft palate	http://purl.obolibrary.org/obo/HP_0000175	Cleft palate		Cleft palate of the midline of the palate.
http://purl.obolibrary.org/obo/HP_0009101	Submucous cleft lip	http://purl.obolibrary.org/obo/HP_5201010	Microform cleft of the upper lip		A cleft of the lip with overlying mucous membrane.
http://purl.obolibrary.org/obo/HP_0009102	Anterior open-bite malocclusion	http://purl.obolibrary.org/obo/HP_0010807	Open bite		Anterior open bite is a malocclusion characterized by a gap between the anterior teeth (incisors), that is, by a deficiency in the normal vertical overlap between antagonist incisal edges when the posterior teeth are in occlusion.
http://purl.obolibrary.org/obo/HP_0009105	Abnormal ossification of the pubic bone	http://purl.obolibrary.org/obo/HP_0009106	Abnormal pelvis bone ossification		Abnormal ossification (bone tissue formation) affecting the pubic bone, also known as the pubis.
http://purl.obolibrary.org/obo/HP_0009106	Abnormal pelvis bone ossification	http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification		An abnormality of the formation and mineralization of any bone of the bony pelvis.
http://purl.obolibrary.org/obo/HP_0009109	Denervation of the diaphragm	http://purl.obolibrary.org/obo/HP_0000775	Abnormality of the diaphragm		Interruption of the innervation of the diaphragm.
http://purl.obolibrary.org/obo/HP_0009110	Diaphragmatic eventration	http://purl.obolibrary.org/obo/HP_0000775	Abnormality of the diaphragm		A congenital failure of muscular development of part or all of one or both hemidiaphragms, resulting in superior displacement of abdominal viscera and altered lung development.
http://purl.obolibrary.org/obo/HP_0009112	Aplasia of the left hemidiaphragm	http://purl.obolibrary.org/obo/HP_0040046	Abnormal left hemidiaphragm morphology		Congenital absence of the left half of the diaphragm.
http://purl.obolibrary.org/obo/HP_0009113	Diaphragmatic weakness	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		A decrease in the strength of the diaphragm.
http://purl.obolibrary.org/obo/HP_0009115	Aplasia/hypoplasia involving the skeleton	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Absence (due to failure to form) or underdevelopment of one or more components of the skeleton.
http://purl.obolibrary.org/obo/HP_0009120	Aplasia/Hypoplasia involving the sinuses	http://purl.obolibrary.org/obo/HP_0009116	Aplasia/Hypoplasia involving bones of the skull		Absence or underdevelopment of a cranial sinus or sinuses.
http://purl.obolibrary.org/obo/HP_0009122	Aplasia/hypoplasia affecting bones of the axial skeleton	http://purl.obolibrary.org/obo/HP_0009115	Aplasia/hypoplasia involving the skeleton		Absence (due to failure to form) or underdevelopment of bones of the axial skeleton.
http://purl.obolibrary.org/obo/HP_0009126	Increased adipose tissue	http://purl.obolibrary.org/obo/HP_0009025	Increased connective tissue		An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).
http://purl.obolibrary.org/obo/HP_0009129	Upper limb amyotrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Muscular atrophy involving the muscles of the upper limbs.
http://purl.obolibrary.org/obo/HP_0009131	Abnormality of the musculature of the thorax	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		A disease or lesion affecting the muscles of the thorax.
http://purl.obolibrary.org/obo/HP_0009132	Abnormal tarsal bone mineral density	http://purl.obolibrary.org/obo/HP_0004348	Abnormality of bone mineral density		This term applies to all changes in bone mineral density of the tarsal bones, which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone.
http://purl.obolibrary.org/obo/HP_0009138	Synostosis involving bones of the lower limbs	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		An abnormal union between bones or parts of bones lower limbs.
http://purl.obolibrary.org/obo/HP_0009147	Enlarged epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010249	Enlarged epiphyses of the distal phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009148	Small epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010254	Small epiphyses of the distal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009149	Triangular epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010256	Triangular epiphyses of the distal phalanges of the hand		A triangular appearance of the epiphysis of the distal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009150	Abnormality of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0004213	Abnormal 5th finger phalanx morphology		Abnormality of the proximal phalanx of the little (5th) finger.
http://purl.obolibrary.org/obo/HP_0009152	Abnormality of the epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009153	Abnormality of the epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		Abnormality of the epiphysis of the proximal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009154	Triangular epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010278	Triangular epiphyses of the proximal phalanges of the hand		A triangular appearance of the epiphysis of the proximal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009155	Cone-shaped epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010270	Cone-shaped epiphyses of the proximal phalanges of the hand		A cone-shaped appearance of the epiphysis of the proximal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009157	Ivory epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010274	Ivory epiphyses of the proximal phalanges of the hand		Sclerosis of the epiphysis of the proximal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009158	Enlarged epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009385	Enlarged epiphyses of the 5th finger		Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009159	Small epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010276	Small epiphyses of the proximal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009160	Absent epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010268	Absent epiphyses of the proximal phalanges of the hand		Absence of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009161	Aplasia/Hypoplasia of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009376	Aplasia/Hypoplasia of the phalanges of the 5th finger		Absence or underdevelopment (hypoplasia) of the middle phalanx of the little (5th) finger.
http://purl.obolibrary.org/obo/HP_0009162	Absent middle phalanx of 5th finger	http://purl.obolibrary.org/obo/HP_0010239	Aplasia of the middle phalanx of the hand		Absence of the middle phalanx of the little (5th) finger.
http://purl.obolibrary.org/obo/HP_0009165	Stippling of the epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010255	Stippling of the epiphyses of the distal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009166	Fragmentation of the epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010250	Fragmentation of the epiphyses of the distal phalanges of the hand		Fragmented appearance of the epiphysis of the distal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009167	Irregular epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010251	Irregular epiphyses of the distal phalanges of the hand		Irregular radiographic opacity of the epiphysis of the distal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009168	Bullet-shaped middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009845	Bullet-shaped middle phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 5th finger is affected.
http://purl.obolibrary.org/obo/HP_0009169	Broad middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009844	Broad middle phalanx of finger		Increased width of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009170	Osteolytic defects of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009847	Osteolytic defects of the middle phalanges of the hand		Dissolution or degeneration of bone tissue of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009171	Triangular epiphyses of the metacarpals	http://purl.obolibrary.org/obo/HP_0010587	Triangular epiphysis		A triangular appearance of the epiphyses of the metacarpals. These epiphyses are located at the distal end of the metacarpals.
http://purl.obolibrary.org/obo/HP_0009172	Abnormal 4th finger phalanx morphology	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Abnormality of the phalanges of the 4th (ring) finger.
http://purl.obolibrary.org/obo/HP_0009173	Curved middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009846	Curved middle phalanges of the hand		Curved appearance of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009174	Abnormality of the epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009175	Patchy sclerosis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0100907	Sclerosis of the middle phalanx of the 5th finger		Patchy increase in bone density of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009177	Proximal fifth finger symphalangism	http://purl.obolibrary.org/obo/HP_0006152	Proximal finger symphalangism		Fusion of the proximal and middle phalanges of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009179	Deviation of the 5th finger	http://purl.obolibrary.org/obo/HP_0004097	Deviation of finger		Displacement of the 5th finger from its normal position.
http://purl.obolibrary.org/obo/HP_0009180	Ulnar deviation of the 5th finger	http://purl.obolibrary.org/obo/HP_0009465	Ulnar deviation of finger		Displacement of the 5th finger towards the ulnar side.
http://purl.obolibrary.org/obo/HP_0009182	Triangular shaped middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009850	Triangular shaped middle phalanges of the hand		Triangular shaped middle phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009183	Joint contracture of the 5th finger	http://purl.obolibrary.org/obo/HP_0012785	Flexion contracture of finger		Chronic loss of joint motion in the 5th finger due to structural changes in non-bony tissue. The term camptodactyly of the 5th finger is used if the distal and/or proximal interphalangeal joints are affected.
http://purl.obolibrary.org/obo/HP_0009184	Contracture of the distal interphalangeal joint of the 5th finger	http://purl.obolibrary.org/obo/HP_0009697	Contracture of the distal interphalangeal joint of the fingers		Chronic loss of joint motion of the distal interphalangeal joint of the 5th finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009185	Contracture of the proximal interphalangeal joint of the 5th finger	http://purl.obolibrary.org/obo/HP_0009183	Joint contracture of the 5th finger		Proximal interphalangeal (PIP) flexion deformity of the little finger. That is, the PIP joint of a little finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.
http://purl.obolibrary.org/obo/HP_0009186	Contracture of the metacarpophalangeal joint of the 5th finger	http://purl.obolibrary.org/obo/HP_0009183	Joint contracture of the 5th finger		Chronic loss of joint motion of the metacarpophalangeal joint of the 5th finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009187	Bracket epiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010247	Bracket epiphyses of the distal phalanges of the hand		An abnormality of the distal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009188	Pseudoepiphysis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010253	Pseudoepiphyses of the distal phalanges of the hand		A secondary ossification center in the distal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009190	Irregular epiphyses of the metacarpals	http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology		Irregular radiographic opacity of the epiphyses of the metacarpals.
http://purl.obolibrary.org/obo/HP_0009191	Ivory epiphyses of the metacarpals	http://purl.obolibrary.org/obo/HP_0010583	Ivory epiphyses		Sclerosis of the epiphyses of the metacarpals, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009192	Aplasia/Hypoplasia of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009376	Aplasia/Hypoplasia of the phalanges of the 5th finger		Absence or underdevelopment (hypoplasia) of the proximal phalanx of the little (5th) finger.
http://purl.obolibrary.org/obo/HP_0009193	Metacarpal pseudoepiphysis	http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology		A pseudoepiphysis is a secondary ossification center distinct from the normal epiphysis. The normal metacarpal epiphyses are located at the distal ends of the metacarpal bones. Accessory epiphyses (which are also known as pseudoepiphyses) can also occasionally be observed at the proximal ends of the metacarpals, usually involving the 2nd metacarpal bone.
http://purl.obolibrary.org/obo/HP_0009194	Small epiphyses of the metacarpals	http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology		Abnormally small size of the epiphyses located at the distal end of the metacarpals in respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009195	Epiphyseal stippling of the metacarpals	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the metacarpals.
http://purl.obolibrary.org/obo/HP_0009196	Absent metacarpal epiphyses	http://purl.obolibrary.org/obo/HP_0010577	Absent epiphyses		Absence of the epiphyses of the metacarpal bones, which are normally located at the distal ends of the metacarpals.
http://purl.obolibrary.org/obo/HP_0009197	Bracket epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010269	Bracket epiphyses of the proximal phalanges of the hand		An abnormality of the proximal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009199	Irregular epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010273	Irregular epiphyses of the proximal phalanges of the hand		Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009200	Pseudoepiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010275	Pseudoepiphyses of the proximal phalanges of the hand		A secondary ossification center in the proximal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009201	Stippling of the epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010277	Stippling of the epiphyses of the proximal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009202	Fragmentation of the epiphysis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010272	Fragmentation of the epiphyses of the proximal phalanges of the hand		Fragmented appearance of the epiphysis of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009203	Absent epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010257	Absent epiphyses of the middle phalanges of the hand		Absence of the epiphysis located at the proximal end of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009204	Bracket epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010258	Bracket epiphyses of the middle phalanges of the hand		An abnormality of the middle phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009205	Cone-shaped epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010259	Cone-shaped epiphyses of the middle phalanges of the hand		A cone-shaped appearance of the epiphysis of the middle phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009206	Enlarged epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010260	Enlarged epiphyses of the middle phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009207	Fragmentation of the epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010261	Fragmentation of the epiphyses of the middle phalanges of the hand		Fragmented appearance of the epiphysis of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009208	Irregular epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010262	Irregular epiphyses of the middle phalanges of the hand		Irregular radiographic opacity of the epiphysis of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009209	Ivory epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010263	Ivory epiphyses of the middle phalanges of the hand		Sclerosis of the epiphysis of the middle phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009210	Pseudoepiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010264	Pseudoepiphyses of the middle phalanges of the hand		A secondary ossification center in the middle phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009211	Small epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010265	Small epiphyses of the middle phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009212	Stippling of the epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010266	Stippling of the epiphyses of the middle phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009213	Triangular epiphysis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010267	Triangular epiphyses of the middle phalanges of the hand		A triangular appearance of the epiphysis of the middle phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009214	Absent epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010257	Absent epiphyses of the middle phalanges of the hand		Absence of the epiphysis located at the proximal end of the middle phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009215	Bracket epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010258	Bracket epiphyses of the middle phalanges of the hand		An abnormality of the middle phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009216	Cone-shaped epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010259	Cone-shaped epiphyses of the middle phalanges of the hand		A cone-shaped appearance of the epiphysis of the middle phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009217	Enlarged epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010260	Enlarged epiphyses of the middle phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009218	Fragmentation of the epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010261	Fragmentation of the epiphyses of the middle phalanges of the hand		Fragmented appearance of the epiphysis of the middle phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009219	Irregular epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010262	Irregular epiphyses of the middle phalanges of the hand		Irregular radiographic opacity of the epiphysis of the middle phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009220	Ivory epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010263	Ivory epiphyses of the middle phalanges of the hand		Sclerosis of the epiphysis of the middle phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009221	Pseudoepiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010264	Pseudoepiphyses of the middle phalanges of the hand		A secondary ossification center in the middle phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009222	Small epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010265	Small epiphyses of the middle phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009223	Stippling of the epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010266	Stippling of the epiphyses of the middle phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009224	Triangular epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010267	Triangular epiphyses of the middle phalanges of the hand		A triangular appearance of the epiphysis of the middle phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009225	Aplasia of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010242	Aplasia of the proximal phalanges of the hand		Absence of the proximal phalanx of the little (5th) finger.
http://purl.obolibrary.org/obo/HP_0009226	Short proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010241	Short proximal phalanx of finger		Hypoplastic/small proximal phalanx of the fifth finger.
http://purl.obolibrary.org/obo/HP_0009227	Broad proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009852	Broad proximal phalanges of the hand		Increased width of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009228	Bullet-shaped proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009853	Bullet-shaped proximal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 5th finger is affected.
http://purl.obolibrary.org/obo/HP_0009229	Curved proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009854	Curved proximal phalanges of the hand		Curved appearance of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009230	Osteolytic defects of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009855	Osteolytic defects of the proximal phalanges of the hand		Dissolution or degeneration of bone tissue of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009231	Patchy sclerosis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0100911	Sclerosis of the proximal phalanx of the 5th finger		Patchy increase in bone density of the proximal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009233	Triangular shaped proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009858	Triangular shaped proximal phalanges of the hand		Triangular shaped proximal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009234	Fifth ray metacarpophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0009708	Synostosis involving the 5th metacarpal		Congenital fusion of the fifth metacarpal bone with the proximal phalanx of the fifth finger.
http://purl.obolibrary.org/obo/HP_0009236	Rhomboid or triangular shaped 5th finger proximal phalanx	http://purl.obolibrary.org/obo/HP_0009233	Triangular shaped proximal phalanx of the 5th finger		Rhomboid or triangular shaped 5th (little) finger proximal phalanx.
http://purl.obolibrary.org/obo/HP_0009237	Short 5th finger	http://purl.obolibrary.org/obo/HP_0009381	Short finger		Hypoplasia (congenital reduction in size) of the fifth finger, also known as the little finger.
http://purl.obolibrary.org/obo/HP_0009238	Aplasia of the 5th finger	http://purl.obolibrary.org/obo/HP_0006262	Aplasia/Hypoplasia of the 5th finger		Absent 5th (little) finger.
http://purl.obolibrary.org/obo/HP_0009240	Broad distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009836	Broad distal phalanx of finger		Increased width of the distal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009241	Bullet-shaped distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009837	Bullet-shaped distal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 5th finger is affected.
http://purl.obolibrary.org/obo/HP_0009242	Osteolytic defects of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009839	Osteolytic defects of the distal phalanges of the hand		Dissolution or degeneration of bone tissue of the distal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009243	Patchy sclerosis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0100903	Sclerosis of the distal phalanx of the 5th finger		Patchy increase in bone density of the distal phalanx of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009244	Distal fifth finger symphalangism	http://purl.obolibrary.org/obo/HP_0004225	Abnormality of the distal phalanx of the 5th finger		Fusion of the terminal/distal and middle phalanges of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009245	Triangular shaped distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009875	Triangular shaped distal phalanges of the hand		Triangular shaped distal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009246	Aplasia of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009881	Aplasia of distal finger phalanx		Absence of the distal phalanx of the little (5th) finger.
http://purl.obolibrary.org/obo/HP_0009250	Absent epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009393	Absent epiphyses of the 4th finger		Absence of the epiphysis located at the proximal end of the distal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009251	Bracket epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010247	Bracket epiphyses of the distal phalanges of the hand		An abnormality of the distal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009252	Cone-shaped epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010248	Cone-shaped epiphyses of the distal phalanges of the hand		A cone-shaped appearance of the epiphysis of the distal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009253	Enlarged epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010249	Enlarged epiphyses of the distal phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009254	Fragmentation of the epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010250	Fragmentation of the epiphyses of the distal phalanges of the hand		Fragmented appearance of the epiphysis of the distal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009255	Irregular epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010251	Irregular epiphyses of the distal phalanges of the hand		Irregular radiographic opacity of the epiphysis of the distal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009256	Ivory epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010252	Ivory epiphyses of the distal phalanges of the hand		Sclerosis of the epiphysis of the distal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009257	Pseudoepiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010253	Pseudoepiphyses of the distal phalanges of the hand		A secondary ossification center in the distal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009258	Small epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010254	Small epiphyses of the distal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009259	Stippling of the epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010255	Stippling of the epiphyses of the distal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009260	Triangular epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010256	Triangular epiphyses of the distal phalanges of the hand		A triangular appearance of the epiphysis of the distal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009261	Absent epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010268	Absent epiphyses of the proximal phalanges of the hand		Absence of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009262	Bracket epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010269	Bracket epiphyses of the proximal phalanges of the hand		An abnormality of the proximal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009263	Cone-shaped epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010270	Cone-shaped epiphyses of the proximal phalanges of the hand		A cone-shaped appearance of the epiphysis of the proximal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009264	Enlarged epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010271	Enlarged epiphyses of the proximal phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009265	Fragmentation of the epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010272	Fragmentation of the epiphyses of the proximal phalanges of the hand		Fragmented appearance of the epiphysis of the proximal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009266	Irregular epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010273	Irregular epiphyses of the proximal phalanges of the hand		Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009267	Ivory epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010274	Ivory epiphyses of the proximal phalanges of the hand		Sclerosis of the epiphysis of the proximal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009268	Pseudoepiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010275	Pseudoepiphyses of the proximal phalanges of the hand		A secondary ossification center in the proximal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009269	Small epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010276	Small epiphyses of the proximal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009270	Stippling of the epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010277	Stippling of the epiphyses of the proximal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009271	Triangular epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010278	Triangular epiphyses of the proximal phalanges of the hand		A triangular appearance of the epiphysis of the proximal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009272	Aplasia/Hypoplasia of the 4th finger	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		A small/hypoplastic or absent/aplastic 4th (ring) finger.
http://purl.obolibrary.org/obo/HP_0009273	Deviation of the 4th finger	http://purl.obolibrary.org/obo/HP_0004188	Abnormal 4th finger morphology		Displacement of the 4th finger from its normal position.
http://purl.obolibrary.org/obo/HP_0009274	Joint contracture of the 4th finger	http://purl.obolibrary.org/obo/HP_0012785	Flexion contracture of finger		Chronic loss of joint motion in the 4th finger due to structural changes in non-bony tissue. The term camptodactyly of the 4th finger is used if the distal and/or proximal interphalangeal joints are affected.
http://purl.obolibrary.org/obo/HP_0009275	Contracture of the distal interphalangeal joint of the 4th finger	http://purl.obolibrary.org/obo/HP_0009697	Contracture of the distal interphalangeal joint of the fingers		Chronic loss of joint motion of the distal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009276	Contracture of the proximal interphalangeal joint of the 4th finger	http://purl.obolibrary.org/obo/HP_0009274	Joint contracture of the 4th finger		Chronic loss of joint motion of the proximal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue. That is, the PIP joint of a fourth finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.
http://purl.obolibrary.org/obo/HP_0009277	Contracture of the metacarpophalangeal joint of the 4th finger	http://purl.obolibrary.org/obo/HP_0009274	Joint contracture of the 4th finger		Chronic loss of joint motion of the metacarpophalangeal joint of the 4th finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009278	Ulnar deviation of the 4th finger	http://purl.obolibrary.org/obo/HP_0009465	Ulnar deviation of finger		Displacement of the 4th finger towards the ulnar side (i.e., towards the 5th finger).
http://purl.obolibrary.org/obo/HP_0009279	Radial deviation of the 4th finger	http://purl.obolibrary.org/obo/HP_0009273	Deviation of the 4th finger		Displacement of the 4th finger towards the radial side (i.e., towards the thumb).
http://purl.obolibrary.org/obo/HP_0009280	Short 4th finger	http://purl.obolibrary.org/obo/HP_0009381	Short finger		Hypoplasia (congenital reduction in size) of the fourth finger, also known as the ring finger.
http://purl.obolibrary.org/obo/HP_0009281	Aplasia of the 4th finger	http://purl.obolibrary.org/obo/HP_0009272	Aplasia/Hypoplasia of the 4th finger		Absent 4th finger.
http://purl.obolibrary.org/obo/HP_0009285	Curved phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009770	Curved phalanges of the hand		Curved appearance of the phalanges of the 4th (ring) finger.
http://purl.obolibrary.org/obo/HP_0009286	Curved distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009838	Curved distal phalanges of the hand		Curved appearance of the distal phalanx of the 4th (ring) finger.
http://purl.obolibrary.org/obo/HP_0009287	Curved middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009846	Curved middle phalanges of the hand		Curved appearance of the middle phalanx of the 4th (ring) finger.
http://purl.obolibrary.org/obo/HP_0009290	Short distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009882	Short distal phalanx of finger		Hypoplastic/small distal phalanx of the fourth finger.
http://purl.obolibrary.org/obo/HP_0009291	Aplasia of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009881	Aplasia of distal finger phalanx		Absence of the distal phalanx of the ring (4th) finger.
http://purl.obolibrary.org/obo/HP_0009292	Broad distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009836	Broad distal phalanx of finger		Increased width of the distal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009293	Broad middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009844	Broad middle phalanx of finger		Increased width of the middle phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009294	Absent middle phalanx of 4th finger	http://purl.obolibrary.org/obo/HP_0010239	Aplasia of the middle phalanx of the hand		Absence of the middle phalanx of the ring (4th) finger.
http://purl.obolibrary.org/obo/HP_0009295	Short middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009299	Aplasia/Hypoplasia of the middle phalanx of the 4th finger		Hypoplastic/small middle phalanx of the 4th finger, also known as the ring finger.
http://purl.obolibrary.org/obo/HP_0009296	Bullet-shaped middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009845	Bullet-shaped middle phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 4th finger is affected.
http://purl.obolibrary.org/obo/HP_0009297	Osteolytic defects of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009847	Osteolytic defects of the middle phalanges of the hand		Dissolution or degeneration of bone tissue of the middle phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009298	Aplasia of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010242	Aplasia of the proximal phalanges of the hand		Absence of the proximal phalanx of the ring (4th) finger.
http://purl.obolibrary.org/obo/HP_0009301	Short proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010241	Short proximal phalanx of finger		Hypoplastic/small proximal phalanx of the fourth finger.
http://purl.obolibrary.org/obo/HP_0009302	Bullet-shaped distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009837	Bullet-shaped distal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 4th finger is affected.
http://purl.obolibrary.org/obo/HP_0009303	Osteolytic defects of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009839	Osteolytic defects of the distal phalanges of the hand		Dissolution or degeneration of bone tissue of the distal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009304	Patchy sclerosis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0100902	Sclerosis of the distal phalanx of the 4th finger		Uneven (irregular) increase in bone density of the distal phalanx of the fourth finger.
http://purl.obolibrary.org/obo/HP_0009305	Distal fourth finger symphalangism	http://purl.obolibrary.org/obo/HP_0009282	Abnormality of the distal phalanx of the 4th finger		Bony fusion of the middle and distal phalanges of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009306	Triangular shaped distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009875	Triangular shaped distal phalanges of the hand		Triangular shaped distal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009307	Patchy sclerosis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0100906	Sclerosis of the middle phalanx of the 4th finger		Uneven (irregular) increase in bone density of the middle phalanx of the fourth finger.
http://purl.obolibrary.org/obo/HP_0009309	Triangular shaped middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009850	Triangular shaped middle phalanges of the hand		Triangular shaped middle phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009310	Broad proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009852	Broad proximal phalanges of the hand		Increased width of the proximal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009311	Bullet-shaped proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009853	Bullet-shaped proximal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 4th finger is affected.
http://purl.obolibrary.org/obo/HP_0009312	Osteolytic defects of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009855	Osteolytic defects of the proximal phalanges of the hand		Dissolution or degeneration of bone tissue of the proximal phalanx of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009313	Patchy sclerosis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0100910	Sclerosis of the proximal phalanx of the 4th finger		Uneven (irregular) increase in bone density of the proximal phalanx of the fourth finger.
http://purl.obolibrary.org/obo/HP_0009315	Triangular shaped proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009858	Triangular shaped proximal phalanges of the hand		Triangular shaped proximal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009316	Abnormal 3rd finger phalanx morphology	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Abnormality of the phalanges of the 3rd (middle) finger.
http://purl.obolibrary.org/obo/HP_0009317	Deviation of the 3rd finger	http://purl.obolibrary.org/obo/HP_0004150	Abnormal 3rd finger morphology		Displacement of the 3rd finger from its normal position.
http://purl.obolibrary.org/obo/HP_0009318	Aplasia/Hypoplasia of the 3rd finger	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		A small/hypoplastic or absent/aplastic 3rd (middle) finger.
http://purl.obolibrary.org/obo/HP_0009319	Joint contracture of the 3rd finger	http://purl.obolibrary.org/obo/HP_0012785	Flexion contracture of finger		Chronic loss of joint motion in the 3rd finger due to structural changes in non-bony tissue. The term camptodactyly of the 3rd finger is used if the distal and/or proximal interphalangeal joints are affected.
http://purl.obolibrary.org/obo/HP_0009320	Abnormality of the epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009321	Absent epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010257	Absent epiphyses of the middle phalanges of the hand		Absence of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009322	Bracket epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010258	Bracket epiphyses of the middle phalanges of the hand		An abnormality of the middle phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009323	Cone-shaped epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010259	Cone-shaped epiphyses of the middle phalanges of the hand		A cone-shaped appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009324	Enlarged epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010260	Enlarged epiphyses of the middle phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009325	Fragmentation of the epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010261	Fragmentation of the epiphyses of the middle phalanges of the hand		Fragmented appearance of the epiphysis of the middle phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009326	Irregular epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010262	Irregular epiphyses of the middle phalanges of the hand		Irregular radiographic opacity of the epiphysis of the middle phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009327	Ivory epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010263	Ivory epiphyses of the middle phalanges of the hand		Sclerosis of the epiphysis of the middle phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009328	Pseudoepiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010264	Pseudoepiphyses of the middle phalanges of the hand		A secondary ossification center in the middle phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009329	Small epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010265	Small epiphyses of the middle phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009330	Stippling of the epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010266	Stippling of the epiphyses of the middle phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009331	Triangular epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010267	Triangular epiphyses of the middle phalanges of the hand		A triangular appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009335	Absent epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009410	Absent epiphyses of the 3rd finger		Absence of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009336	Bracket epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010247	Bracket epiphyses of the distal phalanges of the hand		An abnormality of the distal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009337	Cone-shaped epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010248	Cone-shaped epiphyses of the distal phalanges of the hand		A cone-shaped appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009338	Enlarged epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010249	Enlarged epiphyses of the distal phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009339	Fragmentation of the epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010250	Fragmentation of the epiphyses of the distal phalanges of the hand		Fragmented appearance of the epiphysis of the distal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009340	Irregular epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010251	Irregular epiphyses of the distal phalanges of the hand		Irregular radiographic opacity of the epiphysis of the distal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009341	Ivory epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010252	Ivory epiphyses of the distal phalanges of the hand		Sclerosis of the epiphysis of the distal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009342	Pseudoepiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010253	Pseudoepiphyses of the distal phalanges of the hand		A secondary ossification center in the distal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009343	Small epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010254	Small epiphyses of the distal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009344	Stippling of the epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010255	Stippling of the epiphyses of the distal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009345	Triangular epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010256	Triangular epiphyses of the distal phalanges of the hand		A triangular appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009346	Absent epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010268	Absent epiphyses of the proximal phalanges of the hand		Absence of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009347	Bracket epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010269	Bracket epiphyses of the proximal phalanges of the hand		An abnormality of the proximal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009348	Cone-shaped epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010270	Cone-shaped epiphyses of the proximal phalanges of the hand		A cone-shaped appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009349	Enlarged epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010271	Enlarged epiphyses of the proximal phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009350	Fragmentation of the epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010272	Fragmentation of the epiphyses of the proximal phalanges of the hand		Fragmented appearance of the epiphysis of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009351	Irregular epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010273	Irregular epiphyses of the proximal phalanges of the hand		Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009352	Ivory epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010274	Ivory epiphyses of the proximal phalanges of the hand		Sclerosis of the epiphysis of the proximal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009353	Pseudoepiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010275	Pseudoepiphyses of the proximal phalanges of the hand		A secondary ossification center in the proximal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009354	Small epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010276	Small epiphyses of the proximal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009355	Stippling of the epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010277	Stippling of the epiphyses of the proximal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009356	Triangular epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010278	Triangular epiphyses of the proximal phalanges of the hand		A triangular appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009374	Broad phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand		Increased width of the phalanges of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009375	Bullet-shaped phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009769	Bullet-shaped phalanges of the hand		A fifth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009376	Aplasia/Hypoplasia of the phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		Aplasia/Hypoplasia of the phalanges of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009377	Patchy sclerosis of 5th finger phalanx	http://purl.obolibrary.org/obo/HP_0100921	Sclerosis of 5th finger phalanx		Uneven increase in bone density of one or more of the phalanges of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009378	Triangular shaped phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009774	Triangular shaped phalanges of the hand		Triangular shaped phalanges of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009379	Rhomboid or triangular shaped 5th finger distal phalanx	http://purl.obolibrary.org/obo/HP_0009245	Triangular shaped distal phalanx of the 5th finger		Rhomboid or triangular shaped 5th (little) finger distal phalanx.
http://purl.obolibrary.org/obo/HP_0009381	Short finger	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		Abnormally short finger associated with developmental hypoplasia.
http://purl.obolibrary.org/obo/HP_0009383	Bracket epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010229	Bracket epiphyses of the phalanges of the hand		An abnormality of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009384	Cone-shaped epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010230	Cone-shaped epiphyses of the phalanges of the hand		A cone-shaped appearance of the epiphyses of the 5th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.
http://purl.obolibrary.org/obo/HP_0009385	Enlarged epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010231	Enlarged epiphyses of the phalanges of the hand		Abnormally large size of the epiphyses of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009386	Fragmentation of the epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010232	Fragmented finger phalanx epiphysis		Fragmented appearance of the epiphyses of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009387	Irregular epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010233	Irregular epiphyses of the phalanges of the hand		Irregular radiographic opacity of the epiphyses of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009388	Ivory epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0100921	Sclerosis of 5th finger phalanx		Sclerosis of the epiphyses of the 5th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009389	Pseudoepiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010235	Pseudoepiphyses of the phalanges of the hand		A secondary ossification center in the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009390	Small epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010236	Small epiphyses of the phalanges of the hand		Abnormally small size of the epiphyses of the 5th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009391	Stippling of the epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010237	Epiphyseal stippling of finger phalanges		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th finger.
http://purl.obolibrary.org/obo/HP_0009392	Triangular epiphyses of the 5th finger	http://purl.obolibrary.org/obo/HP_0010238	Triangular epiphyses of the phalanges of the hand		A triangular appearance of the epiphyses of the 5th finger of the hand.
http://purl.obolibrary.org/obo/HP_0009393	Absent epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010228	Absent epiphyses of the phalanges of the hand		Absence of one or more epiphyses of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009394	Bracket epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010229	Bracket epiphyses of the phalanges of the hand		An abnormality of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009395	Cone-shaped epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010230	Cone-shaped epiphyses of the phalanges of the hand		A cone-shaped appearance of the epiphyses of the 4th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.
http://purl.obolibrary.org/obo/HP_0009396	Enlarged epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010231	Enlarged epiphyses of the phalanges of the hand		Abnormally large size of the epiphyses of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009397	Fragmentation of the epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010232	Fragmented finger phalanx epiphysis		Fragmented appearance of the epiphyses of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009398	Irregular epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010233	Irregular epiphyses of the phalanges of the hand		Irregular radiographic opacity of the epiphyses of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009399	Ivory epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0100920	Sclerosis of 4th finger phalanx		Sclerosis of the epiphyses of the 4th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009400	Pseudoepiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010235	Pseudoepiphyses of the phalanges of the hand		A secondary ossification center in the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009401	Small epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010236	Small epiphyses of the phalanges of the hand		Abnormally small size of the epiphyses of the 4th finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009402	Stippling of the epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010237	Epiphyseal stippling of finger phalanges		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009403	Triangular epiphyses of the 4th finger	http://purl.obolibrary.org/obo/HP_0010238	Triangular epiphyses of the phalanges of the hand		A triangular appearance of the epiphyses of the 4th finger of the hand.
http://purl.obolibrary.org/obo/HP_0009404	Broad phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand		Increased width of the phalanges of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009405	Bullet-shaped phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009769	Bullet-shaped phalanges of the hand		A fourth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009406	Patchy sclerosis of 4th finger phalanx	http://purl.obolibrary.org/obo/HP_0100920	Sclerosis of 4th finger phalanx		Uneven increase in bone density of one or more of the phalanges of the fourth (ring) finger.
http://purl.obolibrary.org/obo/HP_0009407	Triangular shaped phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009774	Triangular shaped phalanges of the hand		Triangular shaped phalanges of the 4th finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009410	Absent epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010228	Absent epiphyses of the phalanges of the hand		Absence of the epiphyses of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009411	Bracket epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010229	Bracket epiphyses of the phalanges of the hand		An abnormality of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009412	Cone-shaped epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010230	Cone-shaped epiphyses of the phalanges of the hand		A cone-shaped appearance of the epiphyses of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.
http://purl.obolibrary.org/obo/HP_0009413	Enlarged epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010231	Enlarged epiphyses of the phalanges of the hand		Abnormally large size of the epiphyses of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009414	Fragmentation of the epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010232	Fragmented finger phalanx epiphysis		Fragmented appearance of the epiphyses of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009415	Irregular epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010233	Irregular epiphyses of the phalanges of the hand		Irregular radiographic opacity of the epiphyses of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009416	Ivory epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0100919	Sclerosis of 3rd finger phalanx		Sclerosis of the epiphyses of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009417	Pseudoepiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010235	Pseudoepiphyses of the phalanges of the hand		A secondary ossification center in the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009418	Small epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010236	Small epiphyses of the phalanges of the hand		Abnormally small size of the epiphyses of the 3rd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009419	Stippling of the epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010237	Epiphyseal stippling of finger phalanges		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009420	Triangular epiphyses of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010238	Triangular epiphyses of the phalanges of the hand		A triangular appearance of the epiphyses of the 3rd finger of the hand.
http://purl.obolibrary.org/obo/HP_0009422	Broad distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009836	Broad distal phalanx of finger		Increased width of the distal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009423	Bullet-shaped distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009837	Bullet-shaped distal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 3rd finger is affected.
http://purl.obolibrary.org/obo/HP_0009424	Osteolytic defects of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009839	Osteolytic defects of the distal phalanges of the hand		Dissolution or degeneration of bone tissue of the distal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009425	Patchy sclerosis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0100901	Sclerosis of the distal phalanx of the 3rd finger		Uneven (irregular) increase in bone density of the distal phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0009426	Distal third finger symphalangism	http://purl.obolibrary.org/obo/HP_0009445	Third finger symphalangism		Fusion of the terminal/distal and middle phalanges of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009427	Triangular shaped distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009875	Triangular shaped distal phalanges of the hand		Triangular shaped distal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009428	Curved distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009838	Curved distal phalanges of the hand		Curved appearance of the distal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009429	Aplasia of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009881	Aplasia of distal finger phalanx		Absence of the distal phalanx of the middle (3rd) finger.
http://purl.obolibrary.org/obo/HP_0009430	Broad middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009844	Broad middle phalanx of finger		Increased width of the middle phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009431	Bullet-shaped middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009845	Bullet-shaped middle phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 3rd finger is affected.
http://purl.obolibrary.org/obo/HP_0009432	Curved middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009846	Curved middle phalanges of the hand		Curved appearance of the middle phalanx of the 3rd (middle) finger.
http://purl.obolibrary.org/obo/HP_0009433	Osteolytic defects of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009847	Osteolytic defects of the middle phalanges of the hand		Dissolution or degeneration of bone tissue of the middle phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009434	Patchy sclerosis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0100905	Sclerosis of the middle phalanx of the 3rd finger		Uneven (irregular) increase in bone density of the middle phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0009436	Triangular shaped middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009850	Triangular shaped middle phalanges of the hand		Triangular shaped middle phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009438	Absent middle phalanx of 3rd finger	http://purl.obolibrary.org/obo/HP_0010239	Aplasia of the middle phalanx of the hand		Absence of the middle phalanx of the middle (3rd) finger.
http://purl.obolibrary.org/obo/HP_0009439	Short middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009461	Short 3rd finger		Hypoplasia (congenital reduction in size) of the middle phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0009440	Broad phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand		Increased width of the phalanges of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009441	Bullet-shaped phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009769	Bullet-shaped phalanges of the hand		A third finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009442	Curved phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009770	Curved phalanges of the hand		Curved appearance of the phalanges of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009443	Osteolytic defects of the phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009771	Osteolytic defects of the phalanges of the hand		Dissolution or degeneration of bone tissue of the phalanges of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009444	Patchy sclerosis of 3rd finger phalanx	http://purl.obolibrary.org/obo/HP_0100919	Sclerosis of 3rd finger phalanx		Uneven (irregular) increase in bone density of one or more of the phalanges of the third finger.
http://purl.obolibrary.org/obo/HP_0009445	Third finger symphalangism	http://purl.obolibrary.org/obo/HP_0009316	Abnormal 3rd finger phalanx morphology		Congenital bony fusion of two adjacent phalanges of the third finger.
http://purl.obolibrary.org/obo/HP_0009446	Triangular shaped phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009774	Triangular shaped phalanges of the hand		Triangular shaped phalanges of the 3rd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009450	Broad proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009852	Broad proximal phalanges of the hand		Increased width of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009451	Bullet-shaped proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009853	Bullet-shaped proximal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 3rd finger is affected.
http://purl.obolibrary.org/obo/HP_0009452	Curved proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009854	Curved proximal phalanges of the hand		Curved appearance of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009453	Osteolytic defects of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009855	Osteolytic defects of the proximal phalanges of the hand		Dissolution or degeneration of bone tissue of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009454	Patchy sclerosis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0100909	Sclerosis of the proximal phalanx of the 3rd finger		Uneven (irregular) increase in bone density of the proximal phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0009456	Triangular shaped proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009858	Triangular shaped proximal phalanges of the hand		Triangular shaped proximal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009458	Aplasia of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010242	Aplasia of the proximal phalanges of the hand		Absence of the proximal phalanx of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009459	Short proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010241	Short proximal phalanx of finger		Hypoplasia (congenital reduction in size) of the proximal phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0009460	Aplasia of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009318	Aplasia/Hypoplasia of the 3rd finger		Absent 3rd finger.
http://purl.obolibrary.org/obo/HP_0009461	Short 3rd finger	http://purl.obolibrary.org/obo/HP_0009381	Short finger		Hypoplastic/small 3rd (middle) finger.
http://purl.obolibrary.org/obo/HP_0009462	Radial deviation of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009317	Deviation of the 3rd finger		Displacement of the 3rd finger towards the radial side (i.e., towards the thumb).
http://purl.obolibrary.org/obo/HP_0009463	Ulnar deviation of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009465	Ulnar deviation of finger		Displacement of the 3rd finger towards the ulnar side (i.e., towards the ring finger).
http://purl.obolibrary.org/obo/HP_0009464	Ulnar deviation of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009468	Deviation of the 2nd finger		Displacement of the 2nd (index) finger towards the ulnar side.
http://purl.obolibrary.org/obo/HP_0009465	Ulnar deviation of finger	http://purl.obolibrary.org/obo/HP_0004097	Deviation of finger		Bending or curvature of a finger toward the ulnar side (i.e., away from the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.
http://purl.obolibrary.org/obo/HP_0009467	Radial deviation of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009468	Deviation of the 2nd finger		Displacement of the 2nd finger towards the radial side.
http://purl.obolibrary.org/obo/HP_0009468	Deviation of the 2nd finger	http://purl.obolibrary.org/obo/HP_0004100	Abnormal 2nd finger morphology		Displacement of the 2nd finger from its normal position.
http://purl.obolibrary.org/obo/HP_0009469	Contracture of the distal interphalangeal joint of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009697	Contracture of the distal interphalangeal joint of the fingers		Chronic loss of joint motion of the distal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009470	Contracture of the metacarpophalangeal joint of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009319	Joint contracture of the 3rd finger		Chronic loss of joint motion of the metacarpophalangeal joint of the 3rd finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009471	Contracture of the proximal interphalangeal joint of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009319	Joint contracture of the 3rd finger		Chronic loss of joint motion of the proximal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009477	Proximal fourth finger symphalangism	http://purl.obolibrary.org/obo/HP_0006152	Proximal finger symphalangism		Fusion of the proximal and middle phalanges of the 4th finger.
http://purl.obolibrary.org/obo/HP_0009478	Fourth ray metacarpophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0009707	Synostosis involving the 4th metacarpal		Congenital fusion of the fourth metacarpal bone with the proximal phalanx of the fourth finger.
http://purl.obolibrary.org/obo/HP_0009482	Proximal third finger symphalangism	http://purl.obolibrary.org/obo/HP_0009445	Third finger symphalangism		Fusion of the proximal and middle phalanges of the 3rd finger.
http://purl.obolibrary.org/obo/HP_0009483	Third ray metacarpophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0009706	Synostosis involving the 3rd metacarpal		Congenital fusion of the third metacarpal bone with the proximal phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0009486	Radial deviation of the hand	http://purl.obolibrary.org/obo/HP_0009485	Radial deviation of the hand or of fingers of the hand		An abnormal position of the hand in which the wrist is bent toward the radius (i.e., toward the thumb).
http://purl.obolibrary.org/obo/HP_0009487	Ulnar deviation of the hand	http://purl.obolibrary.org/obo/HP_0001193	Ulnar deviation of the hand or of fingers of the hand		Divergence of the longitudinal axis of the hand at the wrist in a posterior (ulnar) direction (i.e., towards the little finger).
http://purl.obolibrary.org/obo/HP_0009488	Absent epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010228	Absent epiphyses of the phalanges of the hand		Absence of the epiphyses of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009489	Bracket epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010229	Bracket epiphyses of the phalanges of the hand		An abnormality of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009490	Cone-shaped epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010230	Cone-shaped epiphyses of the phalanges of the hand		A cone-shaped appearance of the epiphyses of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.
http://purl.obolibrary.org/obo/HP_0009491	Enlarged epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010231	Enlarged epiphyses of the phalanges of the hand		Abnormally large size of the epiphyses of the 2nd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009492	Fragmentation of the epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010232	Fragmented finger phalanx epiphysis		Fragmented appearance of the epiphyses of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009493	Irregular epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010233	Irregular epiphyses of the phalanges of the hand		Irregular radiographic opacity of the epiphyses of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009494	Ivory epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100918	Sclerosis of 2nd finger phalanx		Sclerosis of the epiphyses of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009495	Pseudoepiphysis of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010235	Pseudoepiphyses of the phalanges of the hand		A secondary ossification center in the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009496	Small epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010236	Small epiphyses of the phalanges of the hand		Abnormally small size of the epiphyses of the 2nd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009497	Stippling of the epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010237	Epiphyseal stippling of finger phalanges		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009498	Triangular epiphyses of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010238	Triangular epiphyses of the phalanges of the hand		A triangular appearance of the epiphyses of the 2nd finger of the hand.
http://purl.obolibrary.org/obo/HP_0009502	Absent epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009499	Abnormality of the epiphysis of the distal phalanx of the 2nd finger		Absence of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009503	Bracket epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010247	Bracket epiphyses of the distal phalanges of the hand		An abnormality of the distal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009504	Cone-shaped epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010248	Cone-shaped epiphyses of the distal phalanges of the hand		A cone-shaped appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009505	Enlarged epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010249	Enlarged epiphyses of the distal phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009506	Fragmentation of the epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010250	Fragmentation of the epiphyses of the distal phalanges of the hand		Fragmented appearance of the epiphysis of the distal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009507	Irregular epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010251	Irregular epiphyses of the distal phalanges of the hand		Irregular radiographic opacity of the epiphysis of the distal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009508	Ivory epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010252	Ivory epiphyses of the distal phalanges of the hand		Sclerosis of the epiphysis of the distal phalanx of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009509	Pseudoepiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010253	Pseudoepiphyses of the distal phalanges of the hand		A secondary ossification center in the distal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009510	Small epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010254	Small epiphyses of the distal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009511	Stippling of the epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010255	Stippling of the epiphyses of the distal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009512	Triangular epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010256	Triangular epiphyses of the distal phalanges of the hand		A triangular appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009514	Bracket epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010258	Bracket epiphyses of the middle phalanges of the hand		An abnormality of the middle phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009520	Pseudoepiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010264	Pseudoepiphyses of the middle phalanges of the hand		A secondary ossification center in the middle phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009525	Bracket epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010269	Bracket epiphyses of the proximal phalanges of the hand		An abnormality of the proximal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009531	Pseudoepiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010275	Pseudoepiphyses of the proximal phalanges of the hand		A secondary ossification center in the proximal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0009535	Aplasia of the 2nd finger	http://purl.obolibrary.org/obo/HP_0006264	Aplasia/Hypoplasia of the 2nd finger		Absent 2nd (index) finger.
http://purl.obolibrary.org/obo/HP_0009536	Short 2nd finger	http://purl.obolibrary.org/obo/HP_0009381	Short finger		Hypoplasia of the second finger, also known as the index finger.
http://purl.obolibrary.org/obo/HP_0009537	Flexion contracture of the 2nd finger	http://purl.obolibrary.org/obo/HP_0012785	Flexion contracture of finger		Chronic loss of joint motion in the 2nd finger due to structural changes in non-bony tissue. The term camptodactyly of the 2nd finger is used if the distal and/or proximal interphalangeal joints are affected.
http://purl.obolibrary.org/obo/HP_0009538	Contracture of the distal interphalangeal joint of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009697	Contracture of the distal interphalangeal joint of the fingers		Chronic loss of joint motion of the distal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009539	Contracture of the metacarpophalangeal joint of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009537	Flexion contracture of the 2nd finger		Chronic loss of joint motion of the metacarpophalangeal joint of the 2nd finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009540	Contracture of the proximal interphalangeal joint of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009537	Flexion contracture of the 2nd finger		Chronic loss of joint motion of the proximal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0009541	Abnormality of the phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0004100	Abnormal 2nd finger morphology		Abnormality of the phalanges of the 2nd (index) finger.
http://purl.obolibrary.org/obo/HP_0009545	Second finger symphalangism	http://purl.obolibrary.org/obo/HP_0009541	Abnormality of the phalanges of the 2nd finger		Congenital bony fusion of two adjacent phalanges of the second finger.
http://purl.obolibrary.org/obo/HP_0009546	Triangular shaped phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009541	Abnormality of the phalanges of the 2nd finger		Triangular shaped phalanges of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009548	Bullet-shaped phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009769	Bullet-shaped phalanges of the hand		A second finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009551	Patchy sclerosis of 2nd finger phalanx	http://purl.obolibrary.org/obo/HP_0100918	Sclerosis of 2nd finger phalanx		Uneven (irregular) increase in bone density of one or more of the phalanges of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009554	Preauricular hair displacement	http://purl.obolibrary.org/obo/HP_0009553	Abnormality of the hairline		An tongue-like extension of hair towards the cheeks, in which hair growth extends in front of the ear to the lateral cheekbones.
http://purl.obolibrary.org/obo/HP_0009555	Hypoplasia of the pharynx	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		Underdevelopment of the pharynx.
http://purl.obolibrary.org/obo/HP_0009556	Absent tibia	http://purl.obolibrary.org/obo/HP_0009817	Aplasia involving bones of the lower limbs		Absence of the tibia.
http://purl.obolibrary.org/obo/HP_0009558	Broad distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009836	Broad distal phalanx of finger		Increased width of the distal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009559	Bullet-shaped distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009837	Bullet-shaped distal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 2nd finger is affected.
http://purl.obolibrary.org/obo/HP_0009560	Curved distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009838	Curved distal phalanges of the hand		Curved appearance of the distal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009561	Osteolytic defects of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009839	Osteolytic defects of the distal phalanges of the hand		Dissolution or degeneration of bone tissue of the distal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009562	Patchy sclerosis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100900	Sclerosis of the distal phalanx of the 2nd finger		Uneven (irregular) increase in bone density of the distal phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0009563	Distal second finger symphalangism	http://purl.obolibrary.org/obo/HP_0009545	Second finger symphalangism		Bony fusion of the terminal/distal and middle phalanges of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009564	Triangular shaped distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009875	Triangular shaped distal phalanges of the hand		Triangular shaped distal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009566	Short distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009882	Short distal phalanx of finger		Hypoplasia (congenital reduction in size) of the distal phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0009569	Broad middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009844	Broad middle phalanx of finger		Increased width of the middle phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0009570	Bullet-shaped middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009845	Bullet-shaped middle phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 2nd finger is affected.
http://purl.obolibrary.org/obo/HP_0009571	Curved middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009846	Curved middle phalanges of the hand		Curved appearance of the middle phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009572	Osteolytic defects of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009847	Osteolytic defects of the middle phalanges of the hand		Dissolution or degeneration of bone tissue of the middle phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009573	Patchy sclerosis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100904	Sclerosis of the middle phalanx of the 2nd finger		Uneven (irregular) increase in bone density of the middle phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0009575	Triangular shaped middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009850	Triangular shaped middle phalanges of the hand		Triangular shaped middle phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009576	Absent middle phalanx of 2nd finger	http://purl.obolibrary.org/obo/HP_0010239	Aplasia of the middle phalanx of the hand		Absence of the middle phalanx of the index (2nd) finger.
http://purl.obolibrary.org/obo/HP_0009577	Short middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009568	Aplasia/Hypoplasia of the middle phalanx of the 2nd finger		Hypoplasia (congenital reduction in size) of the middle phalanx of the second finger, also known as the index finger.
http://purl.obolibrary.org/obo/HP_0009579	Proximal second finger symphalangism	http://purl.obolibrary.org/obo/HP_0009545	Second finger symphalangism		Fusion of the proximal and middle phalanges of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009581	Broad proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009852	Broad proximal phalanges of the hand		Increased width of the proximal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009582	Bullet-shaped proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009853	Bullet-shaped proximal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 2nd finger is affected.
http://purl.obolibrary.org/obo/HP_0009583	Curved proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009854	Curved proximal phalanges of the hand		Curved appearance of the proximal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009584	Osteolytic defects of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009855	Osteolytic defects of the proximal phalanges of the hand		Dissolution or degeneration of bone tissue of the proximal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009585	Patchy sclerosis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100908	Sclerosis of the proximal phalanx of the 2nd finger		Uneven (irregular) increase in bone density of the proximal phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0009587	Triangular shaped proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009858	Triangular shaped proximal phalanges of the hand		Triangular shaped proximal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009588	Vestibular schwannoma	http://purl.obolibrary.org/obo/HP_0100008	Schwannoma		A vestibular schwannoma (also known as acoustic neuroma, acoustic neurinoma, or acoustic neurilemoma) is a benign, usually slow-growing tumor that develops from the VIIIth cranial nerve supplying the inner ear.
http://purl.obolibrary.org/obo/HP_0009589	Bilateral vestibular schwannoma	http://purl.obolibrary.org/obo/HP_0009588	Vestibular schwannoma		A bilateral vestibular schwannoma (acoustic neurinoma).
http://purl.obolibrary.org/obo/HP_0009590	Unilateral vestibular schwannoma	http://purl.obolibrary.org/obo/HP_0009588	Vestibular schwannoma		A unilateral vestibular schwannoma (acoustic neurinoma).
http://purl.obolibrary.org/obo/HP_0009591	Abnormal vestibulocochlear nerve morphology	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		Any structural anomaly of the vestibulocochlear nerve. The vestibulocochlear nerve consists of the vestibular and cochlear nerves, also known as cranial nerve eight (CN VIII). Each nerve has distinct nuclei within the brainstem. The vestibular nerve is primarily responsible for maintaining body balance and eye movements, while the cochlear nerve is responsible for hearing.
http://purl.obolibrary.org/obo/HP_0009592	Astrocytoma	http://purl.obolibrary.org/obo/HP_0100707	Abnormal astrocyte morphology		Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma.
http://purl.obolibrary.org/obo/HP_0009593	Peripheral schwannoma	http://purl.obolibrary.org/obo/HP_0100008	Schwannoma		The presence of a peripheral schwannoma.
http://purl.obolibrary.org/obo/HP_0009594	Retinal hamartoma	http://purl.obolibrary.org/obo/HP_0010568	Hamartoma of the eye		A hamartoma (a benign, focal malformation consisting of a disorganized mixture of cells and tissues) of the retina.
http://purl.obolibrary.org/obo/HP_0009596	Aplasia of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010242	Aplasia of the proximal phalanges of the hand		Absence of the proximal phalanx of the 2nd finger.
http://purl.obolibrary.org/obo/HP_0009597	Short proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010241	Short proximal phalanx of finger		Hypoplasia (congenital reduction in size) of the proximal phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0009598	Second ray metacarpophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0009705	Synostosis involving the 2nd metacarpal		Congenital fusion of the second metacarpal bone with the proximal phalanx of the second finger.
http://purl.obolibrary.org/obo/HP_0009599	Abnormality of thumb epiphysis	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Abnormality of one or all of the epiphyses of the proximal, and distal phalanges of the thumb and/or the 1st metacarpal.
http://purl.obolibrary.org/obo/HP_0009600	Thumb contracture	http://purl.obolibrary.org/obo/HP_0001172	Abnormal thumb morphology		Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the thumb joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin. The term camptodactyly is used if the distal and/or proximal interphalangeal joints are affected.
http://purl.obolibrary.org/obo/HP_0009601	Aplasia/Hypoplasia of the thumb	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		Hypoplastic/small or absent thumb.
http://purl.obolibrary.org/obo/HP_0009602	Abnormality of thumb phalanx	http://purl.obolibrary.org/obo/HP_0001172	Abnormal thumb morphology		A structural anomaly of one or more phalanges of the thumb.
http://purl.obolibrary.org/obo/HP_0009606	Complete duplication of distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010001	Complete duplication of the distal phalanges of the hand		Complete duplication of the distal phalanx of the thumb. On x-ray two separate bones appear side to side.
http://purl.obolibrary.org/obo/HP_0009608	Complete duplication of proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010002	Complete duplication of the middle phalanges of the hand		Complete duplication of the proximal phalanx of the thumb. On x-ray two separate bones appear side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009609	Duplication of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		Partail or complete duplication of the first metacarpal bone.
http://purl.obolibrary.org/obo/HP_0009611	Bifid distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010004	Partial duplication of the distal phalanges of the hand		Partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones.
http://purl.obolibrary.org/obo/HP_0009612	Duplication of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009942	Duplication of thumb phalanx		Complete or partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side.
http://purl.obolibrary.org/obo/HP_0009613	Duplication of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand		Complete or partial duplication of the proximal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009614	Bifid proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010005	Partial duplication of the middle phalanges of the hand		This term applies if the proximal phalanx of the thumb is partially duplicated. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009615	Complete duplication of the first metacarpal	http://purl.obolibrary.org/obo/HP_0010000	Complete duplication of the proximal phalanges of the hand		Complete duplication of the first metacarpal bone.
http://purl.obolibrary.org/obo/HP_0009616	Bifid first metacarpal	http://purl.obolibrary.org/obo/HP_0010003	Partial duplication of the proximal phalanges of the hand		Partial duplication of the first metacarpal bone.
http://purl.obolibrary.org/obo/HP_0009618	Abnormality of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009602	Abnormality of thumb phalanx		An anomaly of the shape or form of the proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009622	Distally placed thumb	http://purl.obolibrary.org/obo/HP_0009603	Deviation of the thumb		Insertion of thumb at a more distal location than normal.
http://purl.obolibrary.org/obo/HP_0009623	Proximal placement of thumb	http://purl.obolibrary.org/obo/HP_0009603	Deviation of the thumb		Proximal mislocalization of the thumb.
http://purl.obolibrary.org/obo/HP_0009624	Carpometacarpal thumb joint contracture	http://purl.obolibrary.org/obo/HP_0009600	Thumb contracture		Chronic loss of joint motion of the carpometacarpal joint of the thumb due to structural changes in non-bony tissue. This joint is formed by the first metacarpal and the trapezial bone and is also called Articulatio carpometacarpalis pollicis, carpometacarpal articulation of thumb, carpometacarpal joint of thumb or first carpometacarpal articulation. Seldom referred to as thumb saddle joint.
http://purl.obolibrary.org/obo/HP_0009625	Metacarpophalangeal thumb joint contracture	http://purl.obolibrary.org/obo/HP_0009600	Thumb contracture		Chronic loss of joint motion of the metacarpophalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio metacarpophalangealis pollicis.
http://purl.obolibrary.org/obo/HP_0009626	Interphalangeal thumb joint contracture	http://purl.obolibrary.org/obo/HP_0009600	Thumb contracture		Chronic loss of joint motion of the interphalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio interphalangealis pollicis.
http://purl.obolibrary.org/obo/HP_0009629	Aplasia/Hypoplasia of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009658	Aplasia/Hypoplasia of the phalanges of the thumb		This term applies if the proximal phalanx of the thumb is either small/hypoplastic or absent. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009630	Broad proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009852	Broad proximal phalanges of the hand		Increased width of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009631	Bullet-shaped proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009845	Bullet-shaped middle phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the thumb is affected.
http://purl.obolibrary.org/obo/HP_0009632	Curved proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009854	Curved proximal phalanges of the hand		A deviation from the normal straight shape of the proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009633	Osteolytic defect of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009847	Osteolytic defects of the middle phalanges of the hand		Dissolution or degeneration of bone tissue of the proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009634	Patchy sclerosis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0100913	Sclerosis of the proximal phalanx of the thumb		An uneven increase in bone density of the proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009635	Synostosis of thumb phalanx	http://purl.obolibrary.org/obo/HP_0009618	Abnormality of the proximal phalanx of the thumb		Fusion of a phalanx of the thumb with another bone.
http://purl.obolibrary.org/obo/HP_0009636	Triangular shaped proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009858	Triangular shaped proximal phalanges of the hand		Triangular shaped proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009637	Absent proximal phalanx of thumb	http://purl.obolibrary.org/obo/HP_0010239	Aplasia of the middle phalanx of the hand		Absence of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009638	Short proximal phalanx of thumb	http://purl.obolibrary.org/obo/HP_0009660	Short phalanx of the thumb		Hypoplastic (short) proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009640	First ray metacarpophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0009703	Synostosis involving the 1st metacarpal		Congenital fusion of the first metacarpal bone with the proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009642	Broad distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009836	Broad distal phalanx of finger		Increased width of the distal phalanx of thumb.
http://purl.obolibrary.org/obo/HP_0009643	Bullet-shaped distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009837	Bullet-shaped distal phalanges of the hand		Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the thumb is affected.
http://purl.obolibrary.org/obo/HP_0009644	Curved distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009838	Curved distal phalanges of the hand		A deviation from the normal straight shape of the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009645	Osteolytic defect of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009839	Osteolytic defects of the distal phalanges of the hand		Dissolution or degeneration of bone tissue of the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009646	Patchy sclerosis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0100912	Sclerosis of the distal phalanx of the thumb		An uneven increase in bone density of the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009648	Triangular shaped distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009875	Triangular shaped distal phalanges of the hand		Triangular shaped distal phalanx of the thumb. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.
http://purl.obolibrary.org/obo/HP_0009649	Aplasia of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009881	Aplasia of distal finger phalanx		Absence of the distal/terminal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009650	Short distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009882	Short distal phalanx of finger		Hypoplastic (short) distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009652	Bullet-shaped thumb phalanx	http://purl.obolibrary.org/obo/HP_0009769	Bullet-shaped phalanges of the hand		An abnormal morphology of one or more phalanges of the thumb, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009653	Curved thumb phalanx	http://purl.obolibrary.org/obo/HP_0009770	Curved phalanges of the hand		A deviation from the normal straight shape of a thumb phalanx.
http://purl.obolibrary.org/obo/HP_0009654	Osteolytic defect of thumb phalanx	http://purl.obolibrary.org/obo/HP_0009771	Osteolytic defects of the phalanges of the hand		Dissolution or degeneration of bone tissue of one or more phalanges of the thumb.
http://purl.obolibrary.org/obo/HP_0009655	Patchy sclerosis of thumb phalanx	http://purl.obolibrary.org/obo/HP_0100922	Sclerosis of thumb phalanx		An uneven increase in bone density of one or more of the phalanges of the thumb.
http://purl.obolibrary.org/obo/HP_0009656	Thumb symphalangism	http://purl.obolibrary.org/obo/HP_0009635	Synostosis of thumb phalanx		Congenital fusion (ankylosis) of the interphalangeal joint of the thumb.
http://purl.obolibrary.org/obo/HP_0009657	Triangular shaped thumb phalanx	http://purl.obolibrary.org/obo/HP_0009602	Abnormality of thumb phalanx		Abnormal shape of one or more phalanges of the thumb such that affected phalanges resemble a triangle.
http://purl.obolibrary.org/obo/HP_0009659	Partial absence of thumb	http://purl.obolibrary.org/obo/HP_0009658	Aplasia/Hypoplasia of the phalanges of the thumb		The absence of a phalangeal segment of a thumb.
http://purl.obolibrary.org/obo/HP_0009660	Short phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009778	Short thumb		Hypoplastic (short) thumb phalanx.
http://purl.obolibrary.org/obo/HP_0009662	Abnormality of the epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		Abnormality of the epiphysis of the distal phalanx of the thumb. This epiphysis is located on the proximal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009663	Abnormality of the epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		This term applies if the epiphysis of the proximal phalanx of the thumb, which is located at the proximal end of the phalanx, does not appear in concordance with gender and age dependant norms as seen on x-rays. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009664	Absent epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010257	Absent epiphyses of the middle phalanges of the hand		Absence of the epiphysis located at the proximal end of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009665	Bracket epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010258	Bracket epiphyses of the middle phalanges of the hand		An abnormality of the proximal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009666	Cone-shaped epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010259	Cone-shaped epiphyses of the middle phalanges of the hand		A cone-shaped appearance of the epiphysis of the proximal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009667	Enlarged epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010260	Enlarged epiphyses of the middle phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009668	Fragmentation of the epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010261	Fragmentation of the epiphyses of the middle phalanges of the hand		Epiphysis of the proximal phalanx of the thumb having multiple bony fragments.
http://purl.obolibrary.org/obo/HP_0009669	Irregular epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010262	Irregular epiphyses of the middle phalanges of the hand		Irregular radiographic opacity of the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009670	Ivory epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010263	Ivory epiphyses of the middle phalanges of the hand		Sclerosis of the epiphysis of the proximal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009671	Pseudoepiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010264	Pseudoepiphyses of the middle phalanges of the hand		A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009672	Small epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010265	Small epiphyses of the middle phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009673	Stippling of the epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010266	Stippling of the epiphyses of the middle phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009674	Triangular epiphysis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010267	Triangular epiphyses of the middle phalanges of the hand		A triangular appearance of the epiphysis of the proximal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009675	Absent epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009686	Absent epiphyses of the thumb		Absence of the epiphysis located at the proximal end of the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009676	Bracket epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010247	Bracket epiphyses of the distal phalanges of the hand		An abnormality of the distal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009677	Cone-shaped epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010248	Cone-shaped epiphyses of the distal phalanges of the hand		A cone-shaped appearance of the epiphysis of the distal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.
http://purl.obolibrary.org/obo/HP_0009678	Enlarged epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010249	Enlarged epiphyses of the distal phalanges of the hand		Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009679	Fragmentation of the epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010250	Fragmentation of the epiphyses of the distal phalanges of the hand		Epiphysis of the distal phalanx of the thumb having multiple bony fragments.
http://purl.obolibrary.org/obo/HP_0009680	Irregular epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010251	Irregular epiphyses of the distal phalanges of the hand		Uneven radiographic opacity of the epiphysis of the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009681	Ivory epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010252	Ivory epiphyses of the distal phalanges of the hand		Sclerosis of the epiphysis of the distal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009682	Pseudoepiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010253	Pseudoepiphyses of the distal phalanges of the hand		A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009683	Small epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010254	Small epiphyses of the distal phalanges of the hand		Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009684	Stippling of the epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010255	Stippling of the epiphyses of the distal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0009685	Triangular epiphysis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0010256	Triangular epiphyses of the distal phalanges of the hand		A triangular appearance of the epiphysis of the distal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.
http://purl.obolibrary.org/obo/HP_0009686	Absent epiphyses of the thumb	http://purl.obolibrary.org/obo/HP_0010228	Absent epiphyses of the phalanges of the hand		Absence of one or more epiphyses of the thumb.
http://purl.obolibrary.org/obo/HP_0009687	Bracket epiphyses of the thumb	http://purl.obolibrary.org/obo/HP_0010229	Bracket epiphyses of the phalanges of the hand		An abnormality of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0009688	Cone-shaped epiphysis of the thumb	http://purl.obolibrary.org/obo/HP_0010230	Cone-shaped epiphyses of the phalanges of the hand		A cone-shaped appearance of the epiphyses of the thumb, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.
http://purl.obolibrary.org/obo/HP_0009689	Enlarged thumb epiphysis	http://purl.obolibrary.org/obo/HP_0010231	Enlarged epiphyses of the phalanges of the hand		Abnormally large size of the epiphyses of the thumb with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009690	Fragmentation of thumb epiphysis	http://purl.obolibrary.org/obo/HP_0010232	Fragmented finger phalanx epiphysis		Epiphysis of the thumb having multiple bony fragments.
http://purl.obolibrary.org/obo/HP_0009691	Irregular thumb epiphysis	http://purl.obolibrary.org/obo/HP_0010233	Irregular epiphyses of the phalanges of the hand		Uneven radiographic opacity of the one or more epiphyses of the thumb.
http://purl.obolibrary.org/obo/HP_0009692	Ivory epiphysis of the thumb	http://purl.obolibrary.org/obo/HP_0100922	Sclerosis of thumb phalanx		Sclerosis of one or more of the epiphyses of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0009693	Pseudoepiphysis of the thumb	http://purl.obolibrary.org/obo/HP_0010235	Pseudoepiphyses of the phalanges of the hand		A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of one or more phalanges of the thumb.
http://purl.obolibrary.org/obo/HP_0009694	Small thumb epiphysis	http://purl.obolibrary.org/obo/HP_0010236	Small epiphyses of the phalanges of the hand		Abnormally small size of one or more of the epiphyses of the thumb with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0009695	Stippling of thumb epiphysis	http://purl.obolibrary.org/obo/HP_0010237	Epiphyseal stippling of finger phalanges		The presence of abnormal punctate (speckled, dot-like) calcifications in one or more of the epiphyses of the thumb.
http://purl.obolibrary.org/obo/HP_0009697	Contracture of the distal interphalangeal joint of the fingers	http://purl.obolibrary.org/obo/HP_0001220	Interphalangeal joint contracture of finger		Chronic loss of joint motion in one or more distal interphalangeal joints of the fingers.
http://purl.obolibrary.org/obo/HP_0009701	Metacarpal synostosis	http://purl.obolibrary.org/obo/HP_0004278	Synostosis involving bones of the hand		Fusion involving two or more metacarpal bones (A synostosis of the first metacarpal and the proximal phalanx of the thumb can also be observed, note that the first metacarpal bone corresponds to a proximal phalanx).
http://purl.obolibrary.org/obo/HP_0009703	Synostosis involving the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		Fusion of the 1st metacarpal with another bone. In contrast to the proximal phalanges of the digits 2 to 5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009704	Chronic CSF lymphocytosis	http://purl.obolibrary.org/obo/HP_0200149	CSF lymphocytic pleiocytosis		Chronic cerebrospinal fluid (CSF) lymphocytosis is defined as the finding, in at least two serial CSF examinations, of more than 5 cells per cubic millimeter.
http://purl.obolibrary.org/obo/HP_0009709	Increased CSF interferon alpha	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Increased concentration of interferon alpha in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0009710	Chilblains	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Chilblains, also called perniosis, are an inflammatory skin condition related to an abnormal vascular response to the cold. We are unaware of a reliable estimate of incidence. It typically presents as tender, pruritic red or bluish lesions located symmetrically on the dorsal aspect of the fingers, toes, ears and nose. Less commonly, reports describe involvement of the thighs and buttocks. The lesions present hours after exposure to cold and usually resolve spontaneously in one to three weeks.
http://purl.obolibrary.org/obo/HP_0009711	Retinal capillary hemangioma	http://purl.obolibrary.org/obo/HP_0010797	Hemangioblastoma		A benign vascular tumor of the retina without any neoplastic characteristics.
http://purl.obolibrary.org/obo/HP_0009713	Spinal hemangioblastoma	http://purl.obolibrary.org/obo/HP_0010797	Hemangioblastoma		A hemangioblastoma of the spinal cord.
http://purl.obolibrary.org/obo/HP_0009715	Papillary cystadenoma of the epididymis	http://purl.obolibrary.org/obo/HP_0009714	Abnormal epididymis morphology		A cystadenoma, an epithelial tumor, that originates within the head of the epididymis.
http://purl.obolibrary.org/obo/HP_0009716	Subependymal nodules	http://purl.obolibrary.org/obo/HP_0009731	Cerebral hamartoma		Small nodular masses which originate in the subependymal region of the lateral ventricles and protrude into the ventricular cavity. They may represent subependymal hamartomas of tuberous sclerosis.
http://purl.obolibrary.org/obo/HP_0009717	Cortical tubers	http://purl.obolibrary.org/obo/HP_0009731	Cerebral hamartoma		Cortical tubers in the brain are hamartomatous lesions typically located at the gray-white matter interface, commonly in the frontal and parietal lobes. Cortical tubers are composed of abnormal glial and neural cells, and the size, number, and location vary among patients.
http://purl.obolibrary.org/obo/HP_0009718	Subependymal giant-cell astrocytoma	http://purl.obolibrary.org/obo/HP_0009592	Astrocytoma		A demarcated, largely intraventricular tumor in the region of the foramen of Monro composed of spindle to large plump or ganglion-like cells with eosinophilic to amphophilic cytoplasm and somewhat pleomorphic nuclei with occasional prominent nucleoli. These tumors are almost always associated with tuberous sclerosis.
http://purl.obolibrary.org/obo/HP_0009719	Hypomelanotic macule	http://purl.obolibrary.org/obo/HP_0020073	Hypopigmented macule		Hypomelanotic macules ("ash leaf spots") are white or lighter patches of skin that may appear anywhere on the body and are caused by a lack of melanin. White ash leaf-shaped macules are considered to be characteristic of tuberous sclerosis.
http://purl.obolibrary.org/obo/HP_0009720	Adenoma sebaceum	http://purl.obolibrary.org/obo/HP_0010615	Angiofibromas		The presence of a sebaceous adenoma with origin in the sebum secreting cells of the skin.
http://purl.obolibrary.org/obo/HP_0009721	Shagreen patch	http://purl.obolibrary.org/obo/HP_0100898	Connective tissue nevi		A plaque representing a connective-tissue nevus. Connective tissue naevi are uncommon skin lesions that occur when the deeper layers of the skin do not develop correctly or the components of these layers occur in the wrong proportion. Shagreen patches are oval-shaped and nevoid, skin-colored or occasionally pigmented, smooth or crinkled. The word shagreen refers to a type of roughened untanned leather.
http://purl.obolibrary.org/obo/HP_0009722	Dental enamel pits	http://purl.obolibrary.org/obo/HP_0000682	Abnormal dental enamel morphology		The presence of small depressions in the dental enamel.
http://purl.obolibrary.org/obo/HP_0009723	Abnormal subungual morphology	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		A lesion located beneath a fingernail or toenail.
http://purl.obolibrary.org/obo/HP_0009724	Subungual fibromas	http://purl.obolibrary.org/obo/HP_0009723	Abnormal subungual morphology		The presence of fibromata beneath finger or toenails.
http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm	http://purl.obolibrary.org/obo/HP_0010786	Urinary tract neoplasm		The presence of a neoplasm of the kidney.
http://purl.obolibrary.org/obo/HP_0009727	Achromatic retinal patches	http://purl.obolibrary.org/obo/HP_0007894	Fundus hypopigmentation		Areas of the retina lacking pigmentation. Punched out areas of chorioretinal hypopigmentation less than 1 disk diameter in size and tending to be located in the midperiphery of the retina.
http://purl.obolibrary.org/obo/HP_0009729	Cardiac rhabdomyoma	http://purl.obolibrary.org/obo/HP_0100544	Neoplasm of the heart		A benign tumor of cardiac striated muscle.
http://purl.obolibrary.org/obo/HP_0009730	Rhabdomyoma	http://purl.obolibrary.org/obo/HP_0009728	Neoplasm of striated muscle		A benign tumor of striated muscle.
http://purl.obolibrary.org/obo/HP_0009732	Plexiform neurofibroma	http://purl.obolibrary.org/obo/HP_0001067	Neurofibroma		A neurofibroma in which Schwann cells proliferate inside the nerve sheath, producing an irregularly thickened, distorted, tortuous structure.
http://purl.obolibrary.org/obo/HP_0009734	Optic nerve glioma	http://purl.obolibrary.org/obo/HP_0009733	Glioma		A glioma originating in the optic nerve or optic chiasm.
http://purl.obolibrary.org/obo/HP_0009735	Spinal neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized in the spine.
http://purl.obolibrary.org/obo/HP_0009736	Tibial pseudarthrosis	http://purl.obolibrary.org/obo/HP_0005864	Pseudoarthrosis		Pseudarthrosis, or "false joint" of the tibia is the result of a developmental failure in the tibia progressing to spontaneous fracture and subsequent fibrous nonunion. The fracture is rarely present at birth but commonly develops during the first 18 months of life.
http://purl.obolibrary.org/obo/HP_0009737	Lisch nodules	http://purl.obolibrary.org/obo/HP_0034819	Iris nodule		The presence of pigmented, oval and dome-shaped raised hamartomatous nevi of the iris..
http://purl.obolibrary.org/obo/HP_0009739	Hypoplasia of the antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		Developmental hypoplasia of the antihelix.
http://purl.obolibrary.org/obo/HP_0009740	Aplasia of the parotid gland	http://purl.obolibrary.org/obo/HP_0000197	Abnormal parotid gland morphology		Absence of the parotid gland.
http://purl.obolibrary.org/obo/HP_0009741	Nephrosclerosis	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Nephrosclerosis refers to thickening or scarring ("sclerosis") resulting from damage to the renal arterioles, also referred to as arteriosclerosis of the kidney arteries.
http://purl.obolibrary.org/obo/HP_0009742	Stiff shoulders	http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology		Shoulder joint stiffness is a perceived sensation of tightness in shoulders when attempting to move them after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0009743	Distichiasis	http://purl.obolibrary.org/obo/HP_0008496	Multiple rows of eyelashes		Double rows of eyelashes.
http://purl.obolibrary.org/obo/HP_0009744	Abnormal spinal dura mater morphology	http://purl.obolibrary.org/obo/HP_0010652	Abnormal dura mater morphology		An abnormality of the spinal dura mater, which is the outermost of the three layers of the meninges surrounding the spinal cord.
http://purl.obolibrary.org/obo/HP_0009745	Spinal arachnoid cyst	http://purl.obolibrary.org/obo/HP_0100702	Arachnoid cyst		Presence of arachnoid cysts of the spinal canal extradurally in the epidural space.
http://purl.obolibrary.org/obo/HP_0009746	Thick nasal septum	http://purl.obolibrary.org/obo/HP_0000419	Abnormal nasal septum morphology		Abnormally increased thickness of the nasal septum.
http://purl.obolibrary.org/obo/HP_0009747	Lumbosacral hirsutism	http://purl.obolibrary.org/obo/HP_0009889	Localized hirsutism		Abnormally increased hair growth in the lumbosacral region.
http://purl.obolibrary.org/obo/HP_0009748	Large earlobe	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Increased volume of the earlobe, that is, abnormally prominent ear lobules.
http://purl.obolibrary.org/obo/HP_0009751	Aplasia of the pectoralis major muscle	http://purl.obolibrary.org/obo/HP_0005258	Pectoral muscle hypoplasia/aplasia		Absence of the pectoralis major muscle.
http://purl.obolibrary.org/obo/HP_0009752	Cleft in skull base	http://purl.obolibrary.org/obo/HP_0002693	Abnormal skull base morphology		A bony defect in the skull base.
http://purl.obolibrary.org/obo/HP_0009754	Fibrous syngnathia	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		Complete or nearly complete soft tissue fusion of the alveolar ridges.
http://purl.obolibrary.org/obo/HP_0009755	Ankyloblepharon	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Partial fusion of the upper and lower eyelid margins by single or multiple bands of tissue.
http://purl.obolibrary.org/obo/HP_0009756	Popliteal pterygium	http://purl.obolibrary.org/obo/HP_0001059	Pterygium		A pterygium (or pterygia) occurring in the popliteal region (the back of the knee).
http://purl.obolibrary.org/obo/HP_0009757	Intercrural pterygium	http://purl.obolibrary.org/obo/HP_0001059	Pterygium		A pterygium (or pterygia) in the intercrural (groin) region.
http://purl.obolibrary.org/obo/HP_0009758	Pyramidal skinfold extending from the base to the top of the nails	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Pyramidal skinfold extending from the base to the top of the nails is a rare and distinctive anomaly seen in popliteal pterygia syndrome.
http://purl.obolibrary.org/obo/HP_0009759	Neck pterygia	http://purl.obolibrary.org/obo/HP_0001059	Pterygium		Pterygia affecting the neck.
http://purl.obolibrary.org/obo/HP_0009760	Antecubital pterygium	http://purl.obolibrary.org/obo/HP_0001059	Pterygium		Pterygium affecting the elbow. This is a cutaneous web that can lead to severe flexion contracture of the elbow joint. Antecubital pterygium can be unilateral, bilateral, symmetric, or asysmmetric.
http://purl.obolibrary.org/obo/HP_0009761	Anterior clefting of vertebral bodies	http://purl.obolibrary.org/obo/HP_0008428	Vertebral clefting		Anterior schisis (cleft or cleavage) of vertebral bodies.
http://purl.obolibrary.org/obo/HP_0009762	Facial wrinkling	http://purl.obolibrary.org/obo/HP_0100678	Premature skin wrinkling		Excessive wrinkling of the skin of the face.
http://purl.obolibrary.org/obo/HP_0009765	Low hanging columella	http://purl.obolibrary.org/obo/HP_0009929	Abnormal columella morphology		Columella extending inferior to the level of the nasal base, when viewed from the side.
http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Small or missing phalangeal bones of the fingers of the hand.
http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand	http://purl.obolibrary.org/obo/HP_0040070	Abnormal upper limb bone morphology		Increased width of the phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0009769	Bullet-shaped phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		The presence of short and wide phalanges which taper distally ("bullet shaped").
http://purl.obolibrary.org/obo/HP_0009771	Osteolytic defects of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009699	Osteolytic defects of the hand bones		Dissolution or degeneration of bone tissue of the phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0009772	Patchy sclerosis of finger phalanx	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		Uneven (irregular) increase in bone density of one or more of the phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0009775	Amniotic constriction ring	http://purl.obolibrary.org/obo/HP_0011409	Abnormal placental membrane morphology		Annular constrictions around the digits, limbs, or trunk, occurring congenitally (sometimes causing intrauterine autoamputation) and also associated with a wide variety of disorders. Constrictive amniotic bands are the result of primary amniotic rupture, which can lead to entanglement of fetal tissue (especially limbs) in fibrous amniotic strands.
http://purl.obolibrary.org/obo/HP_0009776	Adactyly	http://purl.obolibrary.org/obo/HP_6000818	Transverse terminal limb defect		The absence of all phalanges of all the digits of a limb and the associated soft tissues.
http://purl.obolibrary.org/obo/HP_0009777	Absent thumb	http://purl.obolibrary.org/obo/HP_0009601	Aplasia/Hypoplasia of the thumb		Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues.
http://purl.obolibrary.org/obo/HP_0009778	Short thumb	http://purl.obolibrary.org/obo/HP_0009601	Aplasia/Hypoplasia of the thumb		Hypoplasia (congenital reduction in size) of the thumb.
http://purl.obolibrary.org/obo/HP_0009779	3-4 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes three and four.
http://purl.obolibrary.org/obo/HP_0009780	Iliac horns	http://purl.obolibrary.org/obo/HP_0003796	Irregular iliac crest		Horn-like malformations of the iliac crests with symmetrical bilateral central posterior iliac processes. A characteristic finding in the Nail-Patella syndrome. Iliac horns are visible on X-ray and may be palpable, but are asymptomatic.
http://purl.obolibrary.org/obo/HP_0009781	Lester's sign	http://purl.obolibrary.org/obo/HP_0001100	Heterochromia iridis		A zone of darker pigmentation around the central part of the iris with a roughly cloverleaf or flower shape.
http://purl.obolibrary.org/obo/HP_0009782	Aplasia/Hypoplasia of the biceps	http://purl.obolibrary.org/obo/HP_0001468	Aplasia/Hypoplasia involving the musculature of the upper arm		Absence or underdevelopment of the biceps muscle.
http://purl.obolibrary.org/obo/HP_0009783	Biceps aplasia	http://purl.obolibrary.org/obo/HP_0009782	Aplasia/Hypoplasia of the biceps		Absence of the biceps muscle.
http://purl.obolibrary.org/obo/HP_0009784	Aplasia/Hypoplasia of the triceps	http://purl.obolibrary.org/obo/HP_0001468	Aplasia/Hypoplasia involving the musculature of the upper arm		Absence or underdevelopment of the triceps muscle.
http://purl.obolibrary.org/obo/HP_0009785	Triceps aplasia	http://purl.obolibrary.org/obo/HP_0009784	Aplasia/Hypoplasia of the triceps		Absence of the triceps muscle.
http://purl.obolibrary.org/obo/HP_0009786	Aplasia/Hypoplasia of the musculature of the thigh	http://purl.obolibrary.org/obo/HP_0009128	Aplasia/Hypoplasia involving the musculature of the extremities		Absence or underdevelopment involving the musculature of the thigh.
http://purl.obolibrary.org/obo/HP_0009787	Aplasia/Hypoplasia of the quadriceps	http://purl.obolibrary.org/obo/HP_0009786	Aplasia/Hypoplasia of the musculature of the thigh		Absence or underdevelopment of the quadriceps muscle.
http://purl.obolibrary.org/obo/HP_0009788	Quadriceps aplasia	http://purl.obolibrary.org/obo/HP_0009787	Aplasia/Hypoplasia of the quadriceps		Absence of the quadriceps muscle.
http://purl.obolibrary.org/obo/HP_0009789	Perianal abscess	http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology		The presence of an abscess located around the anus.
http://purl.obolibrary.org/obo/HP_0009790	Hemisacrum	http://purl.obolibrary.org/obo/HP_0008490	Sacral segmentation defect		A hemisacral defect involving the sacral vertebrae S2 to S5. In hemisacrum, the first sacral vertebra is intact and there is agenesis involving only S2-S5.
http://purl.obolibrary.org/obo/HP_0009791	Bifid sacrum	http://purl.obolibrary.org/obo/HP_0008490	Sacral segmentation defect		Presence of a bifid sacral bone.
http://purl.obolibrary.org/obo/HP_0009792	Teratoma	http://purl.obolibrary.org/obo/HP_0100728	Germ cell neoplasia		The presence of a teratoma.
http://purl.obolibrary.org/obo/HP_0009793	Presacral teratoma	http://purl.obolibrary.org/obo/HP_0030736	Sacrococcygeal teratoma		A type of sacrococcygeal teratoma located anterior to the sacrum and entirely inside the body (Altman type IV).
http://purl.obolibrary.org/obo/HP_0009794	Branchial anomaly	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Congenital developmental defect arising from the primitive branchial apparatus.
http://purl.obolibrary.org/obo/HP_0009795	Branchial fistula	http://purl.obolibrary.org/obo/HP_0009794	Branchial anomaly		A congenital fistula in the neck resulting from incomplete closure of a branchial cleft.
http://purl.obolibrary.org/obo/HP_0009796	Branchial cyst	http://purl.obolibrary.org/obo/HP_0009794	Branchial anomaly		A branchial cyst is a remnant of embryonic development resulting from a failure of obliteration of a branchial cleft and consists of a subcutaneous cystic mass. Cysts are located anterior or posterior to the ear or in the submandibular region.
http://purl.obolibrary.org/obo/HP_0009800	Maternal diabetes	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Maternal diabetes can either be a gestational, mostly type 2 diabetes, or a type 1 diabetes. Essential is the resulting maternal hyperglycemia as a non-specific teratogen, imposing the same risk of congenital malformations to pregnant women with both type 1 and type2 diabetes.
http://purl.obolibrary.org/obo/HP_0009802	Aplasia of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009823	Aplasia involving bones of the upper limbs		Absence of one or more of the phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0009803	Short phalanx of finger	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		Short (hypoplastic) phalanx of finger, affecting one or more phalanges.
http://purl.obolibrary.org/obo/HP_0009805	Low-output congestive heart failure	http://purl.obolibrary.org/obo/HP_0001635	Congestive heart failure		A form of heart failure characterized by reduced cardiac output. This may be seen in patients with heart failure owing to ischemic heart disease, hypertension, cardiomyopathy, and other causes.
http://purl.obolibrary.org/obo/HP_0009806	Nephrogenic diabetes insipidus	http://purl.obolibrary.org/obo/HP_0000873	Diabetes insipidus		A form of diabetes insipidus caused by failure of the kidneys to respond to vasopressin (AVP).
http://purl.obolibrary.org/obo/HP_0009812	Amelia involving the upper limbs	http://purl.obolibrary.org/obo/HP_6000918	Transverse terminal upper limb defect		Amelia of one or both upper limbs.
http://purl.obolibrary.org/obo/HP_0009813	Upper limb phocomelia	http://purl.obolibrary.org/obo/HP_0009829	Phocomelia		Missing or malformed long bones of the upper limbs with the distal parts (the hands) connected to the variably shortened or even absent upper extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the whole limb is missing (such as amelia), or the distal part of a limb is absent (peromelia).
http://purl.obolibrary.org/obo/HP_0009814	Upper limb peromelia	http://purl.obolibrary.org/obo/HP_0009828	Peromelia		Peromelia affecting only the upper limbs. That is, the distal parts of the arm are missing leading to stump formation.
http://purl.obolibrary.org/obo/HP_0009815	Aplasia/hypoplasia of the extremities	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		Absence (due to failure to form) or underdevelopment of the extremities.
http://purl.obolibrary.org/obo/HP_0009816	Lower limb undergrowth	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		Leg shortening because of underdevelopment of one or more bones of the lower extremity.
http://purl.obolibrary.org/obo/HP_0009818	Amelia involving the lower limbs	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		Complete or near-complete absence of a leg.
http://purl.obolibrary.org/obo/HP_0009819	Lower limb phocomelia	http://purl.obolibrary.org/obo/HP_0009829	Phocomelia		Phocomelia affecting only the lower limbs.
http://purl.obolibrary.org/obo/HP_0009820	Lower limb peromelia	http://purl.obolibrary.org/obo/HP_0009828	Peromelia		Peromelia affecting only the lower limbs. That is, the distal parts of the leg are missing leading to stump formation.
http://purl.obolibrary.org/obo/HP_0009824	Upper limb undergrowth	http://purl.obolibrary.org/obo/HP_0006496	Aplasia/hypoplasia involving bones of the upper limbs		Arm shortening because of underdevelopment of one or more bones of the upper extremity.
http://purl.obolibrary.org/obo/HP_0009828	Peromelia	http://purl.obolibrary.org/obo/HP_0009815	Aplasia/hypoplasia of the extremities		The distal parts of the limbs are missing leading to a stump formation.
http://purl.obolibrary.org/obo/HP_0009829	Phocomelia	http://purl.obolibrary.org/obo/HP_0009815	Aplasia/hypoplasia of the extremities		Missing or malformed long bones of the extremities with the distal parts (such as hands and/or feet) connected to the variably shortened or even absent extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the entire limb is missing (such as amelia), or the distal part of a limb is absent (peromelia).
http://purl.obolibrary.org/obo/HP_0009831	Mononeuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		A focal lesion of a single peripheral nerve. Damage to a sensory nerve is accompanied by sensory impairment of all modalities in the affected anatomic distribution.
http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		An anomaly of middle phalanx of finger.
http://purl.obolibrary.org/obo/HP_0009835	Aplasia/Hypoplasia of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		Absence or underdevelopment of the distal phalanges.
http://purl.obolibrary.org/obo/HP_0009836	Broad distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand		Abnormally wide (broad) distal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0009837	Bullet-shaped distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009769	Bullet-shaped phalanges of the hand		Short and wide distal phalanges that taper distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009840	Patchy sclerosis of distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0100915	Sclerosis of distal phalanx of finger		Uneven (irregular) increase in bone density of the distal phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0009844	Broad middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		Increased width of the middle phalanx of finger.
http://purl.obolibrary.org/obo/HP_0009845	Bullet-shaped middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		Any of the middle phalanges with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009848	Patchy sclerosis of middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0100916	Sclerosis of middle phalanx of finger		Uneven (irregular) increase in bone density of one or more of the middle phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0009852	Broad proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		Increased width of the proximal phalanges of the finger.
http://purl.obolibrary.org/obo/HP_0009853	Bullet-shaped proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		Short and wide proximal phalanges that taper distally . Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0009856	Patchy sclerosis of proximal phalanx of finger	http://purl.obolibrary.org/obo/HP_0100917	Sclerosis of proximal phalanx of finger		Uneven increase in bone density of the proximal phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0009878	Cerebellar ataxia associated with quadrupedal gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		The presence of cerebellar signs and symptoms such as lack of balance associated with quadrupedal gait (locomotion on all four extremities with a 'bear-like' gait with the legs held straight).
http://purl.obolibrary.org/obo/HP_0009879	Simplified gyral pattern	http://purl.obolibrary.org/obo/HP_0002536	Abnormal cortical gyration		An abnormality of the cerebral cortex with fewer gyri but with normal cortical thickness. This pattern is usually often associated with congenital microcephaly.
http://purl.obolibrary.org/obo/HP_0009880	Broad distal phalanges of all fingers	http://purl.obolibrary.org/obo/HP_0009836	Broad distal phalanx of finger		Abnormally wide (broad) distal phalanx of finger of all fingers.
http://purl.obolibrary.org/obo/HP_0009882	Short distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009835	Aplasia/Hypoplasia of the distal phalanges of the hand		Short distance from the end of the finger to the most distal interphalangeal crease or the distal interphalangeal joint flexion point. That is, hypoplasia of one or more of the distal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0009883	Duplication of the distal phalanx of hand	http://purl.obolibrary.org/obo/HP_0009997	Duplication of phalanx of hand		This term applies if one or more of the distal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0009884	Tapered distal phalanges of finger	http://purl.obolibrary.org/obo/HP_0009832	Abnormal distal phalanx morphology of finger		A reduction in diameter of the distal phalanx of finger towards the distal end.
http://purl.obolibrary.org/obo/HP_0009886	Trichorrhexis nodosa	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		Trichorrhexis nodosa is the formation of nodes along the hair shaft through which breakage readily occurs. It is thus a focal defect in the hair fiber that is characterized by thickening or weak points (nodes) that cause the hair to break off easily. The result is defective, abnormally fragile hair.
http://purl.obolibrary.org/obo/HP_0009888	Abnormality of secondary sexual hair	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		Abnormality of the growth of secondary sexual hair, which normally ensues during puberty. In males, secondary sexual hair usually comprises body hair, including underarm, abdominal, chest, and pubic hair. In females, secondary sexual hair usually comprises a lesser degree of body hair, most prominently underarm and pubic hair.
http://purl.obolibrary.org/obo/HP_0009889	Localized hirsutism	http://purl.obolibrary.org/obo/HP_0001007	Hirsutism		Abnormally increased hair growth with a localized distribution.
http://purl.obolibrary.org/obo/HP_0009891	Underdeveloped supraorbital ridges	http://purl.obolibrary.org/obo/HP_0100538	Abnormality of the supraorbital ridges		Flatness of the supraorbital portion of the frontal bones.
http://purl.obolibrary.org/obo/HP_0009892	Anotia	http://purl.obolibrary.org/obo/HP_0008772	Aplasia/Hypoplasia of the external ear		Complete absence of any auricular structures.
http://purl.obolibrary.org/obo/HP_0009893	Telangiectasia of the ear	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		The presence of telangiectasia of the ear.
http://purl.obolibrary.org/obo/HP_0009894	Thickened ears	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Increased thickness of the external ear.
http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		An abnormality of the crus of the helix, which is the horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear.
http://purl.obolibrary.org/obo/HP_0009896	Abnormal antitragus morphology	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		An abnormality of the antitragus, which is a small tubercle opposite to the tragus of the ear. The antitragus and the tragus are separated by the intertragic notch.
http://purl.obolibrary.org/obo/HP_0009897	Horizontal crus of helix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		An abnormal horizontal axis orientation of the crus of the helix. That is, the main axis of the crus of the helix is perpendicular to the medial longitudinal axis of the ear, instead of sloping inferoposteriorly.
http://purl.obolibrary.org/obo/HP_0009898	Underdeveloped crus of the helix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		Developmental hypoplasia of the crus of the helix. That is, flatter and/or shorter crus helix than average.
http://purl.obolibrary.org/obo/HP_0009899	Prominent crus of helix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		The presence of an abnormally prominent of the crus of the helix. That is, development of the crus helix to the same degree as an average antihelix stem or helix.
http://purl.obolibrary.org/obo/HP_0009900	Unilateral deafness	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A unilateral absence of sensory perception of sound.
http://purl.obolibrary.org/obo/HP_0009901	Crumpled ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Distortion of the course of the normal folds of the ear and the appearance of supernumerary crura and folds.
http://purl.obolibrary.org/obo/HP_0009902	Cleft helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		A notched form of the helix of the ear. That is, a defect in the continuity of the helix, which may occur at any point along its length.
http://purl.obolibrary.org/obo/HP_0009903	Conjunctival nodule	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Presence of nodules in the conjunctiva of the eye.
http://purl.obolibrary.org/obo/HP_0009904	Prominent ear helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Abnormally prominent ear helix.
http://purl.obolibrary.org/obo/HP_0009905	Thin ear helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Decreased thickness of the helix of the ear.
http://purl.obolibrary.org/obo/HP_0009907	Attached earlobe	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Attachment of the lobe to the side of the face at the lowest point of the lobe without curving upward.
http://purl.obolibrary.org/obo/HP_0009908	Anterior creases of earlobe	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Sharply demarcated, typically linear and approximately horizontal, indentations in the outer surface of the ear lobe.
http://purl.obolibrary.org/obo/HP_0009909	Uplifted earlobe	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		An abnormal orientation of the earlobes such that they point out- and upward. That is, the lateral surface of ear lobe faces superiorly.
http://purl.obolibrary.org/obo/HP_0009910	Aplasia of the middle ear ossicles	http://purl.obolibrary.org/obo/HP_0004452	Abnormality of the middle ear ossicles		Absence of the middle ear ossicles, malleus, incus, and stapes.
http://purl.obolibrary.org/obo/HP_0009911	Abnormal temporal bone morphology	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		Abnormality of the temporal bone of the skull, which is situated at the sides and base of the skull roughly underlying the region of the face known as the temple.
http://purl.obolibrary.org/obo/HP_0009912	Abnormal tragus morphology	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		An abnormality of the tragus.
http://purl.obolibrary.org/obo/HP_0009913	Aplasia/Hypoplasia of the tragus	http://purl.obolibrary.org/obo/HP_0009912	Abnormal tragus morphology		Aplasia or developmental hypoplasia of the tragus.
http://purl.obolibrary.org/obo/HP_0009914	Cyclopia	http://purl.obolibrary.org/obo/HP_0100886	Abnormality of globe location		Cyclopia is a congenital abnormality in which there is only one eye. That eye is centrally placed in the area normally occupied by the root of the nose.
http://purl.obolibrary.org/obo/HP_0009915	Corneal asymmetry	http://purl.obolibrary.org/obo/HP_0001120	Abnormality of corneal size		The presence of a size difference between the left and right cornea.
http://purl.obolibrary.org/obo/HP_0009916	Anisocoria	http://purl.obolibrary.org/obo/HP_0000615	Abnormal pupil morphology		Anisocoria, or unequal pupil size, may represent a benign physiologic variant or a manifestation of disease.
http://purl.obolibrary.org/obo/HP_0009917	Persistent pupillary membrane	http://purl.obolibrary.org/obo/HP_0000615	Abnormal pupil morphology		The presence of remnants of a fetal membrane that persist as strands of tissue crossing the pupil.
http://purl.obolibrary.org/obo/HP_0009918	Ectopia pupillae	http://purl.obolibrary.org/obo/HP_0000615	Abnormal pupil morphology		A malposition of the pupil owing to a developmental defect of the iris.
http://purl.obolibrary.org/obo/HP_0009919	Retinoblastoma	http://purl.obolibrary.org/obo/HP_0002898	Embryonal neoplasm		A tumor of the eye originating from cells of the retina.
http://purl.obolibrary.org/obo/HP_0009920	Nevus of Ota	http://purl.obolibrary.org/obo/HP_0003764	Nevus		A dermal melanocytic hamartoma that presents as bluish hyperpigmentation on the face along the first or second branches of the trigeminal nerve. Nevus of Ota may involve the sclera.
http://purl.obolibrary.org/obo/HP_0009921	Duane anomaly	http://purl.obolibrary.org/obo/HP_0025068	Incomitant strabismus		A condition associated with a limitation of the horizontal ocular movement with retraction of the globe and narrowing of the palpebral fissure on adduction
http://purl.obolibrary.org/obo/HP_0009922	Vascular remnant arising from the disk	http://purl.obolibrary.org/obo/HP_0007968	Remnants of the hyaloid vascular system		Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disc to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth.
http://purl.obolibrary.org/obo/HP_0009926	Epiphora	http://purl.obolibrary.org/obo/HP_0000632	Lacrimation abnormality		Abnormally increased lacrimation, that is, excessive tearing (watering eye).
http://purl.obolibrary.org/obo/HP_0009927	Aplasia of the nose	http://purl.obolibrary.org/obo/HP_0009924	Aplasia/Hypoplasia involving the nose		Complete absence of all nasal structures.
http://purl.obolibrary.org/obo/HP_0009928	Thick nasal alae	http://purl.obolibrary.org/obo/HP_0000429	Abnormal morphology of the nasal alae		Increase in bulk of the ala nasi.
http://purl.obolibrary.org/obo/HP_0009930	Asymmetry of the nares	http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology		Asymmetry or size difference between the left and right nostril.
http://purl.obolibrary.org/obo/HP_0009931	Enlarged naris	http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology		Increased aperture of the nostril.
http://purl.obolibrary.org/obo/HP_0009932	Single naris	http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology		The presence of only a single nostril.
http://purl.obolibrary.org/obo/HP_0009933	Narrow naris	http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology		Slender, slit-like aperture of the nostril.
http://purl.obolibrary.org/obo/HP_0009934	Supernumerary naris	http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology		The presence of more than two nostrils.
http://purl.obolibrary.org/obo/HP_0009935	Aplasia/Hypoplasia of the nasal septum	http://purl.obolibrary.org/obo/HP_0009924	Aplasia/Hypoplasia involving the nose		Absence or underdevelopment of the nasal septum.
http://purl.obolibrary.org/obo/HP_0009936	Narrow nasal septum	http://purl.obolibrary.org/obo/HP_0000419	Abnormal nasal septum morphology		Abnormally narrow nasal septum.
http://purl.obolibrary.org/obo/HP_0009937	Facial hirsutism	http://purl.obolibrary.org/obo/HP_0009889	Localized hirsutism		Excess facial hair.
http://purl.obolibrary.org/obo/HP_0009938	Sunken cheeks	http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology		Lack or loss of the soft tissues between the zygomata and mandible.
http://purl.obolibrary.org/obo/HP_0009939	Mandibular aplasia	http://purl.obolibrary.org/obo/HP_0009118	Aplasia/Hypoplasia of the mandible		Absence of the mandible.
http://purl.obolibrary.org/obo/HP_0009940	Asymmetry of the mandible	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		Lack of symmetry between the left and right mandible.
http://purl.obolibrary.org/obo/HP_0009941	Asymmetry of the mouth	http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape		The presence of an asymmetric mouth.
http://purl.obolibrary.org/obo/HP_0009942	Duplication of thumb phalanx	http://purl.obolibrary.org/obo/HP_0009602	Abnormality of thumb phalanx		Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0009943	Complete duplication of thumb phalanx	http://purl.obolibrary.org/obo/HP_0009998	Complete duplication of phalanx of hand		A complete duplication affecting one or more of the phalanges of the thumb. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.
http://purl.obolibrary.org/obo/HP_0009944	Partial duplication of thumb phalanx	http://purl.obolibrary.org/obo/HP_0009999	Partial duplication of the phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0009945	Duplication of phalanx of 2nd finger	http://purl.obolibrary.org/obo/HP_0009946	Polydactyly affecting the 2nd finger		This term applies if one or more of the phalanges of the 2nd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0009947	Duplication of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010006	Duplication of the proximal phalanx of hand		Partial or complete duplication of the second proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009948	Duplication of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009945	Duplication of phalanx of 2nd finger		Partial or complete duplication of the distal phalanx of index finger.
http://purl.obolibrary.org/obo/HP_0009949	Duplication of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand		Partial or complete duplication of the middle phalanx of index finger.
http://purl.obolibrary.org/obo/HP_0009950	Complete duplication of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010001	Complete duplication of the distal phalanges of the hand		Complete duplication of the distal phalanx of index finger.
http://purl.obolibrary.org/obo/HP_0009951	Partial duplication of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010004	Partial duplication of the distal phalanges of the hand		Partial duplication of the distal phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009952	Complete duplication of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010002	Complete duplication of the middle phalanges of the hand		Complete duplication of the middle phalanx of index finger.
http://purl.obolibrary.org/obo/HP_0009953	Partial duplication of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010005	Partial duplication of the middle phalanges of the hand		Partial duplication of the middle phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009954	Complete duplication of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010000	Complete duplication of the proximal phalanges of the hand		Complete duplication of the second proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009955	Partial duplication of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010003	Partial duplication of the proximal phalanges of the hand		Partial duplication of the second proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009956	Partial duplication of the phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009999	Partial duplication of the phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 2nd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0009957	Complete duplication of the phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009998	Complete duplication of phalanx of hand		A complete duplication affecting one or more of the phalanges of the 2nd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.
http://purl.obolibrary.org/obo/HP_0009959	Duplication of phalanx of 3rd finger	http://purl.obolibrary.org/obo/HP_0009958	Polydactyly affecting the 3rd finger		This term applies if one or more of the phalanges of the 3rd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0009960	Complete duplication of the phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009998	Complete duplication of phalanx of hand		A complete duplication affecting one or more of the phalanges of the 3rd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.
http://purl.obolibrary.org/obo/HP_0009961	Partial duplication of the phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009999	Partial duplication of the phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 3rd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0009962	Duplication of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009959	Duplication of phalanx of 3rd finger		Partial or complete duplication of the distal phalanx of middle finger.
http://purl.obolibrary.org/obo/HP_0009963	Duplication of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand		Partial or complete duplication of the middle phalanx of middle finger.
http://purl.obolibrary.org/obo/HP_0009964	Duplication of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010006	Duplication of the proximal phalanx of hand		Partial or complete duplication of the third proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009965	Complete duplication of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010001	Complete duplication of the distal phalanges of the hand		Complete duplication of the distal phalanx of middle finger
http://purl.obolibrary.org/obo/HP_0009966	Complete duplication of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010002	Complete duplication of the middle phalanges of the hand		Complete duplication of the middle phalanx of middle finger.
http://purl.obolibrary.org/obo/HP_0009967	Complete duplication of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010000	Complete duplication of the proximal phalanges of the hand		Complete duplication of the third proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009968	Partial duplication of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010004	Partial duplication of the distal phalanges of the hand		Partial duplication of the distal phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009969	Partial duplication of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010005	Partial duplication of the middle phalanges of the hand		Partial duplication of the middle phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009970	Partial duplication of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010003	Partial duplication of the proximal phalanges of the hand		Partial duplication of the third proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009972	Duplication of phalanx of 4th finger	http://purl.obolibrary.org/obo/HP_0009971	Polydactyly affecting the 4th finger		This term applies if one or more of the phalanges of the 4th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0009973	Complete duplication of the phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009998	Complete duplication of phalanx of hand		A complete duplication affecting one or more of the phalanges of the 4th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.
http://purl.obolibrary.org/obo/HP_0009974	Partial duplication of the phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009999	Partial duplication of the phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 4th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0009975	Duplication of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009972	Duplication of phalanx of 4th finger		Partial or complete duplication of the distal phalanx of ring finger.
http://purl.obolibrary.org/obo/HP_0009976	Duplication of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand		Partial or complete duplication of the middle phalanx of ring finger.
http://purl.obolibrary.org/obo/HP_0009977	Duplication of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010006	Duplication of the proximal phalanx of hand		Partial or complete duplication of the fourth proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009978	Complete duplication of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010001	Complete duplication of the distal phalanges of the hand		Complete duplication of the distal phalanx of ring finger.
http://purl.obolibrary.org/obo/HP_0009979	Complete duplication of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010002	Complete duplication of the middle phalanges of the hand		Complete duplication of the middle phalanx of ring finger.
http://purl.obolibrary.org/obo/HP_0009980	Complete duplication of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010000	Complete duplication of the proximal phalanges of the hand		Complete duplication of the fourth proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009981	Partial duplication of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010004	Partial duplication of the distal phalanges of the hand		Partial duplication of the distal phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009982	Partial duplication of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010005	Partial duplication of the middle phalanges of the hand		Partial duplication of the middle phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009983	Partial duplication of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010003	Partial duplication of the proximal phalanges of the hand		Partial duplication of the fourth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009985	Duplication of phalanx of 5th finger	http://purl.obolibrary.org/obo/HP_0004213	Abnormal 5th finger phalanx morphology		This term applies if one or more of the phalanges of the 5th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0009986	Complete duplication of the phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009998	Complete duplication of phalanx of hand		A complete duplication affecting one or more of the phalanges of the 5th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.
http://purl.obolibrary.org/obo/HP_0009987	Partial duplication of the phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0009999	Partial duplication of the phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 5th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0009988	Duplication of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009985	Duplication of phalanx of 5th finger		Partial or complete duplication of the distal phalanx of little finger.
http://purl.obolibrary.org/obo/HP_0009989	Duplication of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand		Partial or complete duplication of the fifth middle phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009990	Duplication of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010006	Duplication of the proximal phalanx of hand		Partial or complete duplication of the fifth proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009991	Complete duplication of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010001	Complete duplication of the distal phalanges of the hand		Complete duplication of the distal phalanx of little finger.
http://purl.obolibrary.org/obo/HP_0009992	Complete duplication of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010002	Complete duplication of the middle phalanges of the hand		Complete duplication of the fifth middle phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009993	Complete duplication of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010000	Complete duplication of the proximal phalanges of the hand		Complete duplication of the fifth proximal phalanx of hand.
http://purl.obolibrary.org/obo/HP_0009994	Partial duplication of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010004	Partial duplication of the distal phalanges of the hand		Partial duplication of the distal phalanx of little finger, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009995	Partial duplication of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010005	Partial duplication of the middle phalanges of the hand		Partial duplication of the fifth middle phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009996	Partial duplication of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0010003	Partial duplication of the proximal phalanges of the hand		Partial or complete duplication of the fifth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.
http://purl.obolibrary.org/obo/HP_0009998	Complete duplication of phalanx of hand	http://purl.obolibrary.org/obo/HP_0009997	Duplication of phalanx of hand		A complete duplication affecting one or more of the phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.
http://purl.obolibrary.org/obo/HP_0009999	Partial duplication of the phalanx of hand	http://purl.obolibrary.org/obo/HP_0009997	Duplication of phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0010000	Complete duplication of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010006	Duplication of the proximal phalanx of hand		A complete duplication affecting one or more of the proximal phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.
http://purl.obolibrary.org/obo/HP_0010001	Complete duplication of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009998	Complete duplication of phalanx of hand		A complete duplication affecting one or more of the distal phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0010002	Complete duplication of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand		A complete duplication affecting one or more of the middle phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a pseudoepiphysis (see corresponding terms) sometimes also referred to as hyperphalangism.
http://purl.obolibrary.org/obo/HP_0010003	Partial duplication of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010006	Duplication of the proximal phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the proximal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0010004	Partial duplication of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009999	Partial duplication of the phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the distal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0010005	Partial duplication of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand		A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the middle phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.
http://purl.obolibrary.org/obo/HP_0010006	Duplication of the proximal phalanx of hand	http://purl.obolibrary.org/obo/HP_0009997	Duplication of phalanx of hand		This term applies if one or more of the proximal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0010008	Duplication of the middle phalanx of hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		This term applies if one or more of the middle phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.
http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		A structural anomaly of the first metacarpal.
http://purl.obolibrary.org/obo/HP_0010010	Abnormal 2nd metacarpal morphology	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Any abnormality of the second metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010011	Abnormal 3rd metacarpal morphology	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Any abnormality of the third metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010012	Abnormal 4th metacarpal morphology	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Any abnormality of the fourth metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010013	Abnormal 5th metacarpal morphology	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Any abnormality of the fifth metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010014	Abnormality of the epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits). The epiphysis of the first metacarpal is localized at the proximal end (as seen in the proximal phalanges of the other digits), whereas the epiphyses of the other metacarpal bones are located at the distal end. This term applies if the epiphysis of the 1st metacarpal is in any way abnormal, referring to age and gender depending norms, as seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010016	Bracket epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0200050	Bracket metacarpal epiphyses		An epiphysis that curves around from its transverse orientation to a longitudinal one from proximal to distal along one side of the phalanx, thus resembling the letter 'C' and forming a bracket around the diaphysis. This results in a so called delta phalanx characterized by a triangular or trapezoidal shaped bone with a C-shaped epiphyseal plate.
http://purl.obolibrary.org/obo/HP_0010017	Cone-shaped epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010270	Cone-shaped epiphyses of the proximal phalanges of the hand		A cone-shaped appearance of the epiphysis of the 1st metacarpal, producing a 'ball-in-a-socket' appearance.
http://purl.obolibrary.org/obo/HP_0010018	Enlarged epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010271	Enlarged epiphyses of the proximal phalanges of the hand		Abnormally large size of the epiphyses of the 1st metacarpal with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0010019	Fragmentation of the epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0009189	Fragmented metacarpal epiphysis		Epiphysis of the 1st metacarpal having multiple bony fragments.
http://purl.obolibrary.org/obo/HP_0010020	Irregular epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010273	Irregular epiphyses of the proximal phalanges of the hand		Uneven radiographic opacity of the epiphysis of the 1st metacarpal.
http://purl.obolibrary.org/obo/HP_0010021	Ivory epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010274	Ivory epiphyses of the proximal phalanges of the hand		The epiphysis of the 1st metacarpal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0010022	Pseudoepiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010275	Pseudoepiphyses of the proximal phalanges of the hand		The epiphysis of the first metacarpal is localized at the proximal end of the metacarpal bone although an accessory epiphysis may be located at the distal end of the metacarpal.
http://purl.obolibrary.org/obo/HP_0010023	Small epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010276	Small epiphyses of the proximal phalanges of the hand		Abnormally small size of the epiphysis of the 1st metacarpal with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0010024	Epiphyseal stippling of the first metacarpal	http://purl.obolibrary.org/obo/HP_0010277	Stippling of the epiphyses of the proximal phalanges of the hand		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the first metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010026	Aplasia/Hypoplasia of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		Aplasia or Hypoplasia affecting the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits).
http://purl.obolibrary.org/obo/HP_0010027	Broad 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		Increased width of the 1st metacarpal. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.
http://purl.obolibrary.org/obo/HP_0010028	Bullet-shaped 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		The presence of short and wide 1st metacarpal which tapers distally ("bullet shaped").
http://purl.obolibrary.org/obo/HP_0010029	Curved 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		A deviation from the normal straight shape of the first metacarpal.
http://purl.obolibrary.org/obo/HP_0010030	Osteolytic defects of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		Dissolution or degeneration of bone tissue of the 1st metacarpal.
http://purl.obolibrary.org/obo/HP_0010031	Patchy sclerosis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0100914	Sclerosis of the 1st metacarpal		Uneven increase in bone density within the 1st metacarpal.
http://purl.obolibrary.org/obo/HP_0010033	Triangular shaped 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009	Abnormal 1st metacarpal morphology		This term applies to a triangular shaped 1st metacarpal.
http://purl.obolibrary.org/obo/HP_0010034	Short 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		A developmental defect characterized by reduced length of the first metacarpal (long bone) of the hand.
http://purl.obolibrary.org/obo/HP_0010035	Aplasia of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010242	Aplasia of the proximal phalanges of the hand		Absent first metacarpal (long bone) of the hand.
http://purl.obolibrary.org/obo/HP_0010036	Aplasia/Hypoplasia of the 2nd metacarpal	http://purl.obolibrary.org/obo/HP_0010010	Abnormal 2nd metacarpal morphology		Aplasia or Hypoplasia affecting the 2nd metacarpal.
http://purl.obolibrary.org/obo/HP_0010037	Aplasia of the 2nd metacarpal	http://purl.obolibrary.org/obo/HP_0010048	Aplasia of metacarpal bones		Absence of the second long bone of the hand.
http://purl.obolibrary.org/obo/HP_0010038	Short 2nd metacarpal	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		Short second metacarpal bone because of developmental hypoplasia.
http://purl.obolibrary.org/obo/HP_0010039	Aplasia/Hypoplasia of the 3rd metacarpal	http://purl.obolibrary.org/obo/HP_0010011	Abnormal 3rd metacarpal morphology		Aplasia or Hypoplasia affecting the 3rd metacarpal.
http://purl.obolibrary.org/obo/HP_0010040	Aplasia of the 3rd metacarpal	http://purl.obolibrary.org/obo/HP_0010048	Aplasia of metacarpal bones		Absence of the third long bone of the hand.
http://purl.obolibrary.org/obo/HP_0010041	Short 3rd metacarpal	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		Short third metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010042	Aplasia/Hypoplasia of the 4th metacarpal	http://purl.obolibrary.org/obo/HP_0010012	Abnormal 4th metacarpal morphology		Aplasia or Hypoplasia affecting the 4th metacarpal.
http://purl.obolibrary.org/obo/HP_0010043	Aplasia of the 4th metacarpal	http://purl.obolibrary.org/obo/HP_0010048	Aplasia of metacarpal bones		Absence of the fourth long bone of the hand.
http://purl.obolibrary.org/obo/HP_0010044	Short 4th metacarpal	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		Short fourth metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010045	Aplasia/Hypoplasia of the 5th metacarpal	http://purl.obolibrary.org/obo/HP_0010013	Abnormal 5th metacarpal morphology		Aplasia or Hypoplasia affecting the 5th metacarpal.
http://purl.obolibrary.org/obo/HP_0010046	Aplasia of the 5th metacarpal	http://purl.obolibrary.org/obo/HP_0010048	Aplasia of metacarpal bones		Absence of the fifth long bone of the hand.
http://purl.obolibrary.org/obo/HP_0010047	Short 5th metacarpal	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		Short fifth metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010048	Aplasia of metacarpal bones	http://purl.obolibrary.org/obo/HP_0005914	Aplasia/Hypoplasia involving the metacarpal bones		Developmental defect associated with absence of one or more metacarpal bones.
http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal	http://purl.obolibrary.org/obo/HP_0005914	Aplasia/Hypoplasia involving the metacarpal bones		Diminished length of one or more metacarpal bones in relation to the others of the same hand or to the contralateral metacarpal.
http://purl.obolibrary.org/obo/HP_0010052	Abnormal morphology of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		An abnormal shape or form of the proximal phalanx of the big toe.
http://purl.obolibrary.org/obo/HP_0010054	Abnormality of the first metatarsal bone	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		An anomaly of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010055	Broad hallux	http://purl.obolibrary.org/obo/HP_0001844	Abnormal hallux morphology		Visible increase in width of the hallux without an increase in the dorso-ventral dimension.
http://purl.obolibrary.org/obo/HP_0010059	Broad hallux phalanx	http://purl.obolibrary.org/obo/HP_0010174	Broad phalanx of the toes		An increase in width in one or more phalanges of the big toe.
http://purl.obolibrary.org/obo/HP_0010060	Bullet-shaped hallux phalanx	http://purl.obolibrary.org/obo/HP_0010175	Bullet-shaped toe phalanx		An abnormal morphology of one or more phalanges of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010061	Curved hallux phalanx	http://purl.obolibrary.org/obo/HP_0010176	Curved toe phalanx		A deviation from the normal straight form of one or more phalanges of the big toe.
http://purl.obolibrary.org/obo/HP_0010063	Patchy sclerosis of hallux phalanx	http://purl.obolibrary.org/obo/HP_0100930	Sclerosis of hallux phalanx		Patchy (irregular) increase in bone density of one or more phalanges of the big toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010066	Duplication of phalanx of hallux	http://purl.obolibrary.org/obo/HP_0010181	Duplication of phalanx of toe		Partial or complete duplication of one or more phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010067	Aplasia/hypoplasia of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010054	Abnormality of the first metatarsal bone		Absence or underdevelopment of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010068	Broad first metatarsal	http://purl.obolibrary.org/obo/HP_0010054	Abnormality of the first metatarsal bone		Increased side-to-side width of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010069	Bullet-shaped 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010054	Abnormality of the first metatarsal bone		An abnormal morphology of the firstmetatarsal bone, which is short and wide and tapers distally, and lacks the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010070	Curved 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010054	Abnormality of the first metatarsal bone		A deviation from the normal straight shape of a proximal phalanx of the 1st metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010071	Osteolytic defects of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010062	Osteolytic defects of the phalanges of the hallux		Dissolution or degeneration of bone tissue of the first metatarsal.
http://purl.obolibrary.org/obo/HP_0010075	Duplication of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010054	Abnormality of the first metatarsal bone		A developmental defect consisting in the duplication of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010077	Broad distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010186	Broad distal phalanx of the toes		An increase in width of the distal phalanx of the big toe.
http://purl.obolibrary.org/obo/HP_0010078	Bullet-shaped distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010187	Bullet-shaped distal toe phalanx		An abnormal morphology of the distal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010079	Curved distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010188	Curved distal toe phalanx		A deviation from the normal straight form of the distal phalanx of the big toe.
http://purl.obolibrary.org/obo/HP_0010086	Broad proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010204	Broad proximal phalanx of toe		Increased width of proximal phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010087	Bullet-shaped proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010205	Bullet-shaped proximal toe phalanx		An abnormal morphology of the proximal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010088	Curved proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010206	Curved proximal toe phalanx		A deviation from the normal straight form of the proximal phalanx of the big toe.
http://purl.obolibrary.org/obo/HP_0010093	Duplication of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010202	Duplication of middle phalanx of toe		Partial or complete duplication of the proximal phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010094	Complete duplication of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010100	Complete duplication of hallux phalanx		Complete duplication of the proximal phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010095	Partial duplication of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010101	Partial duplication of the phalanges of the hallux		Partial duplication of the proximal phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010098	Complete duplication of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010075	Duplication of the 1st metatarsal		A developmental defect consisting in the complete duplication of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010099	Partial duplication of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010101	Partial duplication of the phalanges of the hallux		A developmental defect consisting in the duplication of part of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010100	Complete duplication of hallux phalanx	http://purl.obolibrary.org/obo/HP_0010066	Duplication of phalanx of hallux		Complete duplication of one or more phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010103	Short distal phalanx of hallux	http://purl.obolibrary.org/obo/HP_0010111	Short phalanx of hallux		Underdevelopment (hypoplasia) of the distal phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010104	Absent first metatarsal	http://purl.obolibrary.org/obo/HP_0010744	Absent metatarsal bone		A developmental defect characterized by the absence of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010105	Short first metatarsal	http://purl.obolibrary.org/obo/HP_0010743	Short metatarsal		Short first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010107	Short proximal phalanx of hallux	http://purl.obolibrary.org/obo/HP_0010111	Short phalanx of hallux		Underdevelopment (hypoplasia) of the proximal phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010109	Short hallux	http://purl.obolibrary.org/obo/HP_0008362	Aplasia/Hypoplasia of the hallux		Underdevelopment (hypoplasia) of the big toe.
http://purl.obolibrary.org/obo/HP_0010111	Short phalanx of hallux	http://purl.obolibrary.org/obo/HP_0010746	Hypoplasia of the phalanges of the toes		Underdevelopment (hypoplasia) of a phalanx of big toe.
http://purl.obolibrary.org/obo/HP_0010112	Mesoaxial foot polydactyly	http://purl.obolibrary.org/obo/HP_0100260	Mesoaxial polydactyly		The presence of a supernumerary toe (not a hallux) involving the third or fourth metatarsal with associated osseous syndactyly.
http://purl.obolibrary.org/obo/HP_0010113	Absent hallux epiphysis	http://purl.obolibrary.org/obo/HP_0010162	Absent epiphyses of the toes		Failure to form (agenesis) of one or more epiphyses of the big toe.
http://purl.obolibrary.org/obo/HP_0010122	Stippling of the epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010171	Epiphyseal stippling of toe phalanges		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the hallux.
http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010056	Abnormality of the epiphyses of the hallux		In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities of the epiphysis of the first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010056	Abnormality of the epiphyses of the hallux		In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities affecting the proximal phalanx of the hallux.
http://purl.obolibrary.org/obo/HP_0010127	Absent epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		Failure to form (agenesis) of the epiphysis of the proximal phalanx of the hallux.
http://purl.obolibrary.org/obo/HP_0010128	Bracket epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		The epiphysis of the proximal phalanx of the hallux surrounds the diaphysis, having a bracket-like form.
http://purl.obolibrary.org/obo/HP_0010134	Pseudoepiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the big toe.
http://purl.obolibrary.org/obo/HP_0010136	Stippling of the epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the hallux.
http://purl.obolibrary.org/obo/HP_0010138	Absent epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		Failure to form (agenesis) of the epiphysis of the distal phalanx of the hallux.
http://purl.obolibrary.org/obo/HP_0010139	Bracket epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		The epiphysis of the distal phalanx of the hallux surrounds the diaphysis, having a bracket-like form.
http://purl.obolibrary.org/obo/HP_0010147	Stippling of the epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the hallux.
http://purl.obolibrary.org/obo/HP_0010149	Absent epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		Failure to form (agenesis) of the epiphysis of the 1st metatarsal.
http://purl.obolibrary.org/obo/HP_0010150	Bracket epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		The epiphysis of the 1st metatarsal surrounds the diaphysis, having a bracket-like form.
http://purl.obolibrary.org/obo/HP_0010151	Cone-shaped epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010630	Abnormal metatarsal epiphysis morphology		A conical (cone-shaped) appearance of the epiphysis of the first metatarsal of the foot.
http://purl.obolibrary.org/obo/HP_0010155	Ivory epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		The epiphysis of the 1st metatarsal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0010162	Absent epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010577	Absent epiphyses		Absence of the epiphyses of the phalanges of the toes.
http://purl.obolibrary.org/obo/HP_0010171	Epiphyseal stippling of toe phalanges	http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the toes.
http://purl.obolibrary.org/obo/HP_0010174	Broad phalanx of the toes	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		Increased width of phalanx of one or more toes.
http://purl.obolibrary.org/obo/HP_0010175	Bullet-shaped toe phalanx	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		An abnormal morphology of one or more phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010176	Curved toe phalanx	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		A deviation from the normal straight form of one or more toe phalanges.
http://purl.obolibrary.org/obo/HP_0010178	Patchy sclerosis of toe phalanx	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		Uneven (irregular) increase in bone density of one or more of the phalanges of the foot.
http://purl.obolibrary.org/obo/HP_0010181	Duplication of phalanx of toe	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		Partial/complete duplication of one or more phalanx of toe.
http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		A morphological anomaly of one or more proximal phalanges of one or more toes.
http://purl.obolibrary.org/obo/HP_0010186	Broad distal phalanx of the toes	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		Increased width of the distal phalanx of toe of one or more toes.
http://purl.obolibrary.org/obo/HP_0010187	Bullet-shaped distal toe phalanx	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		An abnormal morphology of one or more distal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010188	Curved distal toe phalanx	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		A deviation from the normal straight form of one or more distal toe phalanges.
http://purl.obolibrary.org/obo/HP_0010190	Patchy sclerosis of distal toe phalanx	http://purl.obolibrary.org/obo/HP_0100948	Sclerosis of distal phalanx of toe		Patchy (irregular) increase in bone density of one or more of the distal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010193	Duplication of distal phalanx of toe	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		A partial or complete duplication of one or more distal phalanx of toe.
http://purl.obolibrary.org/obo/HP_0010196	Bullet-shaped middle phalanx of toe	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		An abnormal morphology of one or more middle phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010197	Curved middle phalanx of toe	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		A deviation from the normal straight form of one or more middle toe phalanges.
http://purl.obolibrary.org/obo/HP_0010199	Patchy sclerosis of middle phalanx of toe	http://purl.obolibrary.org/obo/HP_0100947	Sclerosis of middle phalanx of toe		Patchy (irregular) increase in bone density of one or more of the middle phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010200	Proximal toe symphalangism	http://purl.obolibrary.org/obo/HP_0100264	Proximal symphalangism		Bony fusion at the proximal interphalangeal joint of a toe other than the hallux (end-to-end fusion of the proximal and medial phalanx of a toe).
http://purl.obolibrary.org/obo/HP_0010202	Duplication of middle phalanx of toe	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		Partial or complete duplication of a middle phalanx of toe.
http://purl.obolibrary.org/obo/HP_0010203	Aplasia/hypoplasia of proximal toe phalanx	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		Absence (agenesis) or underdevelopment of the proximal phalanx of the toe.
http://purl.obolibrary.org/obo/HP_0010204	Broad proximal phalanx of toe	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		An increase in width of one ore more proximal toe phalanges.
http://purl.obolibrary.org/obo/HP_0010205	Bullet-shaped proximal toe phalanx	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		An abnormal morphology of one or more of the proximal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010206	Curved proximal toe phalanx	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		A deviation from the normal straight shape of a proximal phalanx of one or more toes.
http://purl.obolibrary.org/obo/HP_0010207	Osteolytic defect of the proximal toe phalanx	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		Dissolution or degeneration of bone tissue of the proximal toe phalanx.
http://purl.obolibrary.org/obo/HP_0010208	Patchy sclerosis of proximal toe phalanx	http://purl.obolibrary.org/obo/HP_0100946	Sclerosis of proximal phalanx of toe		Patchy (irregular) increase in bone density of one or more of the proximal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010211	Duplication of proximal phalanx of toe	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		Partial/complete duplication of a proximal phalanx of toe.
http://purl.obolibrary.org/obo/HP_0010212	Flexion contracture of the hallux	http://purl.obolibrary.org/obo/HP_0005830	Flexion contracture of toe		One or more bent (flexed) joints of the first (big) toe that cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0010213	Contracture of the tarsometatarsal joint of the hallux	http://purl.obolibrary.org/obo/HP_0010212	Flexion contracture of the hallux		Chronic loss of joint motion in the tarsometatarsal joint of the hallux due to structural changes in non-bony tissue. The tarsometatarsal joints of the feet are also called Lisfranc's joints.
http://purl.obolibrary.org/obo/HP_0010214	Contracture of the interphalangeal joint of the hallux	http://purl.obolibrary.org/obo/HP_0010212	Flexion contracture of the hallux		The interphalangeal joint of the big toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0010215	Contractures of the metatarsophalangeal joint of the hallux	http://purl.obolibrary.org/obo/HP_0010212	Flexion contracture of the hallux		The joint between the first metatarsal and the proximal phalanx of the first (big) toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0010219	Structural foot deformity	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		A foot deformity resulting due to an abnormality affecting the bones of the foot (as well as muscle and soft tissue). In contrast if only the muscle and soft tissue are affected the term positional foot deformity applies.
http://purl.obolibrary.org/obo/HP_0010220	Abnormality of the epiphysis of the 2nd metacarpal	http://purl.obolibrary.org/obo/HP_0010010	Abnormal 2nd metacarpal morphology		Any abnormality of the epiphysis of the second metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010222	Abnormal 3rd metacarpal epiphysis morphology	http://purl.obolibrary.org/obo/HP_0010011	Abnormal 3rd metacarpal morphology		Any abnormality of the epiphysis of the third metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010223	Pseudoepiphysis of the 3rd metacarpal	http://purl.obolibrary.org/obo/HP_0010222	Abnormal 3rd metacarpal epiphysis morphology		The normal epiphysis of the third metacarpal is localized at the distal end of the metacarpal bone. This term applies if an accessory epiphysis, located at the proximal end of the metacarpal bone, is present.
http://purl.obolibrary.org/obo/HP_0010224	Abnormal 4th metacarpal epiphysis morphology	http://purl.obolibrary.org/obo/HP_0010012	Abnormal 4th metacarpal morphology		Any abnormality of the epiphysis of the 4th metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010225	Pseudoepiphysis of the 4th metacarpal	http://purl.obolibrary.org/obo/HP_0010224	Abnormal 4th metacarpal epiphysis morphology		The normal epiphysis of the fourth metacarpal is localized at the distal end of the metacarpal bone. This term applies if an accessory epiphysis, located at the proximal end of the metacarpal bone, is present.
http://purl.obolibrary.org/obo/HP_0010226	Abnormal 5th metacarpal epiphysis morphology	http://purl.obolibrary.org/obo/HP_0010013	Abnormal 5th metacarpal morphology		Any abnormality of the epiphysis of the fifth metacarpal bone.
http://purl.obolibrary.org/obo/HP_0010227	Pseudoepiphysis of the 5th metacarpal	http://purl.obolibrary.org/obo/HP_0010226	Abnormal 5th metacarpal epiphysis morphology		The normal epiphysis of the fifth metacarpal is localized at the distal end of the metacarpal bone. This term applies if an accessory epiphysis, located at the proximal end of the metacarpal bone, is present.
http://purl.obolibrary.org/obo/HP_0010228	Absent epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010577	Absent epiphyses		Absence of one or more epiphyses of the phalanges of the fingers.
http://purl.obolibrary.org/obo/HP_0010229	Bracket epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010578	Bracket epiphyses		Bracket epiphysis refers to an abnormality in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0010230	Cone-shaped epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0034281	Phalangeal cone-shaped epiphyses		A cone-shaped appearance of the epiphyses of the fingers of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.
http://purl.obolibrary.org/obo/HP_0010231	Enlarged epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Abnormally large size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0010232	Fragmented finger phalanx epiphysis	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Fragmented appearance of the epiphyses of the phalanges of the fingers.
http://purl.obolibrary.org/obo/HP_0010233	Irregular epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Irregular radiographic opacity of the epiphyses of the phalanges of the fingers.
http://purl.obolibrary.org/obo/HP_0010234	Ivory epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		Sclerosis of the epiphyses of the phalanges of the fingers, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0010235	Pseudoepiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		A secondary ossification center in the phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0010236	Small epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Abnormally small size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0010237	Epiphyseal stippling of finger phalanges	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the fingers.
http://purl.obolibrary.org/obo/HP_0010238	Triangular epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010587	Triangular epiphysis		A triangular appearance of the epiphyses of the phalanges of the fingers of the hand.
http://purl.obolibrary.org/obo/HP_0010239	Aplasia of the middle phalanx of the hand	http://purl.obolibrary.org/obo/HP_0009843	Aplasia/Hypoplasia of the middle phalanges of the hand		Absence of one or more middle phalanx of a finger.
http://purl.obolibrary.org/obo/HP_0010241	Short proximal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009851	Aplasia/Hypoplasia of the proximal phalanges of the hand		Congenital hypoplasia of one or more proximal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0005920	Abnormal epiphysis morphology of the phalanges of the hand		Any anomaly of distal epiphysis of phalanx of finger.
http://purl.obolibrary.org/obo/HP_0010247	Bracket epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		An abnormality of the distal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0010252	Ivory epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100915	Sclerosis of distal phalanx of finger		Distal epiphyses of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0010253	Pseudoepiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		A secondary ossification center in the distal phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0010258	Bracket epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		An abnormality of the middle phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0010261	Fragmentation of the epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		Fragmented appearance of the epiphyses of the middle phalanges of the hand.
http://purl.obolibrary.org/obo/HP_0010263	Ivory epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100916	Sclerosis of middle phalanx of finger		Epiphyses of the middle phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0010264	Pseudoepiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		A secondary ossification center in the middle phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0010269	Bracket epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		An abnormality of the proximal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.
http://purl.obolibrary.org/obo/HP_0010274	Ivory epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100917	Sclerosis of proximal phalanx of finger		Epiphyses of the proximal phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0010275	Pseudoepiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		A secondary ossification center in the proximal phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.
http://purl.obolibrary.org/obo/HP_0010280	Stomatitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth.
http://purl.obolibrary.org/obo/HP_0010281	Cleft lower lip	http://purl.obolibrary.org/obo/HP_0410030	Cleft lip		A gap in the lower lip.
http://purl.obolibrary.org/obo/HP_0010282	Thin lower lip vermilion	http://purl.obolibrary.org/obo/HP_0000233	Thin vermilion border		Height of the vermilion of the medial part of the lower lip more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the lower lip in the frontal view (subjective).
http://purl.obolibrary.org/obo/HP_0010284	Intra-oral hyperpigmentation	http://purl.obolibrary.org/obo/HP_0100669	Abnormal pigmentation of the oral mucosa		Increased pigmentation, either focal or generalized, of the mucosa of the mouth.
http://purl.obolibrary.org/obo/HP_0010285	Oral synechia	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		Fibrous band between the mucosal surfaces of the upper and lower alveolar ridges.
http://purl.obolibrary.org/obo/HP_0010287	Abnormality of the submandibular glands	http://purl.obolibrary.org/obo/HP_0010286	Abnormal salivary gland morphology		Any abnormality of the submandibular glands, which are the salivary glands that are located beneath the floor of the mouth, superior to the digastric muscles.
http://purl.obolibrary.org/obo/HP_0010288	Abnormality of the sublingual glands	http://purl.obolibrary.org/obo/HP_0010286	Abnormal salivary gland morphology		Any abnormality of the sublingual glands, which are the salivary glands that are located beneath the floor of the mouth anterior to the submandibular glands.
http://purl.obolibrary.org/obo/HP_0010289	Cleft maxillary alveolar ridge	http://purl.obolibrary.org/obo/HP_0000202	Orofacial cleft		A gap (cleft) affecting one of the alveolar ridges, which are the protuberances in the mouth that contain the sockets (alveoli) of the teeth. An alveolar cleft can affect all structures of the alveolar ridge, including the gingiva, other mucosa, periosteum, alveolar bone, and teeth. Alveolar cleft occurs in response to divergence from normal development during frontonasal prominence growth, contact, and fusion. The most common alveolar portion of the cleft is located between the lateral incisor and the canine.
http://purl.obolibrary.org/obo/HP_0010290	Short hard palate	http://purl.obolibrary.org/obo/HP_0100737	Abnormal hard palate morphology		Distance between the labial point of the incisive papilla to the midline junction of the hard and soft palate more than 2 SD below the mean (objective) or apparently decreased length of the hard palate (subjective).
http://purl.obolibrary.org/obo/HP_0010291	Prominent palatine ridges	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		Increased size and/or number of soft tissue folds on the palatal side of the maxillary alveolar ridge.
http://purl.obolibrary.org/obo/HP_0010292	Absent uvula	http://purl.obolibrary.org/obo/HP_0010293	Aplasia/Hypoplasia of the uvula		Lack of the uvula.
http://purl.obolibrary.org/obo/HP_0010293	Aplasia/Hypoplasia of the uvula	http://purl.obolibrary.org/obo/HP_0000172	Abnormal uvula morphology		Underdevelopment or absence of the uvula.
http://purl.obolibrary.org/obo/HP_0010294	Palate fistula	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		A fistula which connects the oral cavity and the pharyngeal area via the aspects of the soft palate.
http://purl.obolibrary.org/obo/HP_0010296	Ankyloglossia	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Short or anteriorly attached lingual frenulum, associated with limited mobility of the tongue.
http://purl.obolibrary.org/obo/HP_0010297	Bifid tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Tongue with a median apical indentation or fork.
http://purl.obolibrary.org/obo/HP_0010298	Smooth tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Glossy appearance of the entire tongue surface.
http://purl.obolibrary.org/obo/HP_0010300	Abnormally low-pitched voice	http://purl.obolibrary.org/obo/HP_5200005	Abnormal pitch		A persistent (minutes to hours) abnormal decrease in the pitch of the voice for the context or social situation or significantly different from the baseline of the individual.
http://purl.obolibrary.org/obo/HP_0010302	Spinal cord tumor	http://purl.obolibrary.org/obo/HP_0100006	Neoplasm of the central nervous system		A neoplasm affecting the spinal cord.
http://purl.obolibrary.org/obo/HP_0010303	Abnormal spinal meningeal morphology	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord.
http://purl.obolibrary.org/obo/HP_0010304	Spinal meningeal diverticulum	http://purl.obolibrary.org/obo/HP_0010303	Abnormal spinal meningeal morphology		An outpouching of the spinal meninges.
http://purl.obolibrary.org/obo/HP_0010305	Absence of the sacrum	http://purl.obolibrary.org/obo/HP_0008517	Aplasia/Hypoplasia of the sacrum		Absence (aplasia) of the sacrum.
http://purl.obolibrary.org/obo/HP_0010306	Short thorax	http://purl.obolibrary.org/obo/HP_0000765	Abnormal thorax morphology		Reduced inferior to superior extent of the thorax.
http://purl.obolibrary.org/obo/HP_0010307	Stridor	http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound		Stridor is a high pitched sound resulting from turbulent air flow in the upper airway.
http://purl.obolibrary.org/obo/HP_0010308	Asternia	http://purl.obolibrary.org/obo/HP_0006714	Aplasia/Hypoplasia of the sternum		The congenital absence of the sternum.
http://purl.obolibrary.org/obo/HP_0010309	Bifid sternum	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		The sternal cleft is a rare congenital anomaly resulting from a fusion failure of the sternum.
http://purl.obolibrary.org/obo/HP_0010310	Chylothorax	http://purl.obolibrary.org/obo/HP_0002202	Pleural effusion		Accumulation of excessive amounts of lymphatic fluid (chyle) in the pleural cavity.
http://purl.obolibrary.org/obo/HP_0010312	Asymmetry of the breasts	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		The presence of asymmetrical breasts.
http://purl.obolibrary.org/obo/HP_0010313	Breast hypertrophy	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		The presence of hypertrophy of the breast.
http://purl.obolibrary.org/obo/HP_0010314	Premature thelarche	http://purl.obolibrary.org/obo/HP_0000826	Precocious puberty		Premature development of the breasts.
http://purl.obolibrary.org/obo/HP_0010315	Aplasia/Hypoplasia of the diaphragm	http://purl.obolibrary.org/obo/HP_0000775	Abnormality of the diaphragm		Absence or underdevelopment of the diaphragm.
http://purl.obolibrary.org/obo/HP_0010316	Ebstein anomaly of the tricuspid valve	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		Ebstein's anomaly refers to an abnormally placed and deformed tricuspid valve characterized by apical displacement of the septal and posterior tricuspid valve leaflets, leading to atrialization of the right ventricle with a variable degree of malformation and displacement of the anterior leaflet.
http://purl.obolibrary.org/obo/HP_0010317	Scapular aplasia	http://purl.obolibrary.org/obo/HP_0006713	Aplasia/Hypoplasia of the scapulae		Absence of the scapulae.
http://purl.obolibrary.org/obo/HP_0010318	Aplasia/Hypoplasia of the abdominal wall musculature	http://purl.obolibrary.org/obo/HP_0010991	Abnormal morphology of the abdominal musculature		Absence or underdevelopment of the abdominal musculature.
http://purl.obolibrary.org/obo/HP_0010319	Abnormal second toe morphology	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		An anomaly of the second toe.
http://purl.obolibrary.org/obo/HP_0010320	Abnormal third toe morphology	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		An anomaly of the third toe.
http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		An anomaly of the fourth toe.
http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology	http://purl.obolibrary.org/obo/HP_0010319	Abnormal second toe morphology		An anomaly of a phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010327	Flexion contracture of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010319	Abnormal second toe morphology		One or more bent (flexed) joints of the second toe that cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0010333	Flexion contracture of 3rd toe	http://purl.obolibrary.org/obo/HP_0010320	Abnormal third toe morphology		One or more bent (flexed) joints of the third toe that cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0010339	Flexion contracture of the 4th toe	http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology		One or more bent (flexed) joints of the fourth toe that cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0010345	Flexion contracture of the 5th toe	http://purl.obolibrary.org/obo/HP_0005830	Flexion contracture of toe		One or more bent (flexed) joints of the fifth toe that cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0010349	Bullet-shaped 2nd toe phalanx	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		An abnormal morphology of one or more phalanges of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010350	Curved 2nd toe phalanx	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		A deviation from the normal straight form of one or more phalanges of the second toe.
http://purl.obolibrary.org/obo/HP_0010352	Patchy sclerosis of 2nd toe phalanx	http://purl.obolibrary.org/obo/HP_0100926	Sclerosis of 2nd toe phalanx		Patchy (irregular) increase in bone density of one or more of the phalanges of the second toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010353	Second toe symphalangism	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		Fusion of an interphalangeal joint of the second toe.
http://purl.obolibrary.org/obo/HP_0010355	Duplication of the phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		Partial or complete duplication of a phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010361	Bullet-shaped 3rd toe phalanx	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		An abnormal morphology of one or more phalanges of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010362	Curved 3rd toe phalanx	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		A deviation from the normal straight form of one or more phalanges of the third toe.
http://purl.obolibrary.org/obo/HP_0010364	Patchy sclerosis of 3rd toe phalanx	http://purl.obolibrary.org/obo/HP_0100927	Sclerosis of 3rd toe phalanx		Patchy (irregular) increase in bone density of one or more of the phalanges of the third toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010365	Third toe symphalangism	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		Fusion of an interphalangeal joint of the third toe.
http://purl.obolibrary.org/obo/HP_0010367	Duplication of phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		Partial or complete duplication of phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0010370	Abnormal morphology of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		An anomaly of the proximal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0010373	Bullet-shaped 4th toe phalanx	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		An abnormal morphology of one or more phalanges of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010374	Curved 4th toe phalanx	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		A deviation from the normal straight form of one or more phalanges of the fourth toe.
http://purl.obolibrary.org/obo/HP_0010376	Patchy sclerosis of 4th toe phalanx	http://purl.obolibrary.org/obo/HP_0100928	Sclerosis of 4th toe phalanx		Patchy (irregular) increase in bone density of one or more of the phalanges of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010377	Fourth toe symphalangism	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		Fusion of an interphalangeal joint of the fourth toe.
http://purl.obolibrary.org/obo/HP_0010379	Duplication of phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		Partial or complete duplication of phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0010385	Bullet-shaped 5th toe phalanx	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		An abnormal morphology of one or more phalanges of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010386	Curved 5th toe phalanx	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		A deviation from the normal straight form of one or more phalanges of the fifth toe.
http://purl.obolibrary.org/obo/HP_0010388	Patchy sclerosis of 5th toe phalanx	http://purl.obolibrary.org/obo/HP_0100929	Sclerosis of 5th toe phalanx		Patchy (irregular) increase in bone density of one or more of the phalanges of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010389	Fifth toe symphalangism	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		Fusion of an interphalangeal joint of the fifth (little) toe.
http://purl.obolibrary.org/obo/HP_0010391	Duplication of the phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		Partial or complete duplication of one or more phalanx of little toe.
http://purl.obolibrary.org/obo/HP_0010395	Aplasia/hypoplasia of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		Absence (agenesis) or underdevelopment of the proximal phalanx of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0010397	Bullet-shaped proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		An abnormal morphology of the proximal phalanx of the 2nd toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010398	Curved proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		A deviation from the normal straight form of the proximal phalanx of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0010401	Proximal 2nd toe symphalangism	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		Bony fusion of the middle and proximal phalanges of the second toe.
http://purl.obolibrary.org/obo/HP_0010403	Duplication of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		Partial or complete duplication of proximal phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010406	Bullet-shaped middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe		An abnormal morphology of the middle phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010407	Curved middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe		A deviation from the normal straight form of the middle phalanx of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0010412	Duplication of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe		Partial or complete duplication of middle phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010415	Bullet-shaped distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		An abnormal morphology of the distal phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0010416	Curved distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		A deviation from the normal straight form of the distal phalanx of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0010419	Distal 2nd toe symphalangism	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		Bony fusion at the distal interphalangeal joint of the second toe (end-to-end fusion of the medial and distal phalanx of the second toe).
http://purl.obolibrary.org/obo/HP_0010421	Duplication of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		Partial or complete duplication of the distal phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010422	Complete duplication of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010429	Complete duplication of the phalanges of the 2nd toe		Complete duplication of proximal phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010423	Partial duplication of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010428	Partial duplication of phalanx of the 2nd toe		Partial duplication of proximal phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010424	Complete duplication of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010429	Complete duplication of the phalanges of the 2nd toe		Complete duplication of the distal phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010425	Partial duplication of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010428	Partial duplication of phalanx of the 2nd toe		Partial duplication of the distal phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010426	Complete duplication of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010429	Complete duplication of the phalanges of the 2nd toe		Complete duplication of middle phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010427	Partial duplication of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010428	Partial duplication of phalanx of the 2nd toe		Partial duplication of middle phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010428	Partial duplication of phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010355	Duplication of the phalanges of the 2nd toe		Partial duplication of a phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010429	Complete duplication of the phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010355	Duplication of the phalanges of the 2nd toe		Complete duplication of a phalanx of second toe.
http://purl.obolibrary.org/obo/HP_0010431	Short phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010746	Hypoplasia of the phalanges of the toes		Reduced length of one or more phalanx of second toe as a result of developmental hypoplasia.
http://purl.obolibrary.org/obo/HP_0010432	Absent distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010645	Aplasia of the distal phalanges of the toes		Absence of distal phalanx of the second toe as a result of developmental aplasia.
http://purl.obolibrary.org/obo/HP_0010433	Short distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010431	Short phalanx of the 2nd toe		Reduced length of the distal phalanx of the second toe as a result of developmental hypoplasia.
http://purl.obolibrary.org/obo/HP_0010435	Short middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010431	Short phalanx of the 2nd toe		Reduced length of the middle phalanx of second toe as a result of developmental hypoplasia.
http://purl.obolibrary.org/obo/HP_0010437	Short proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010431	Short phalanx of the 2nd toe		Reduced length of the proximal phalanx of second toe as a result of developmental hypoplasia.
http://purl.obolibrary.org/obo/HP_0010440	Ectopic accessory toe-like appendage	http://purl.obolibrary.org/obo/HP_0001829	Foot polydactyly		In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the fibular side of the foot, next top the little toe), preaxial (on the tibial side of the foot, next to the big toe) or mesoaxial (somewhere central, between big and little toe), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200).
http://purl.obolibrary.org/obo/HP_0010441	Ectopic accessory finger-like appendage	http://purl.obolibrary.org/obo/HP_0001161	Hand polydactyly		In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the ulnar side of the hand, next to the little finger), preaxial (on the radial side of the hand, next to the thumb) or mesoaxial (somewhere central, between thumb and little finger), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200).
http://purl.obolibrary.org/obo/HP_0010443	Bifid femur	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		A bifid or bifurcated appearance of the femur as seen on x-rays, possible appearing as a more or less severe bowing of the upper leg. Might be associated with hip dysplasia on the affected side.
http://purl.obolibrary.org/obo/HP_0010444	Pulmonic regurgitation	http://purl.obolibrary.org/obo/HP_0031654	Abnormal pulmonary valve physiology		The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole.
http://purl.obolibrary.org/obo/HP_0010445	Primum atrial septal defect	http://purl.obolibrary.org/obo/HP_0001631	Atrial septal defect		An ostium primum atrial septal defect is located in the most anterior and inferior aspect of the atrial septum. The ostium primum refers to an anterior and inferior opening (ostium) within the septum primum, which divides the rudimentary atrium during fetal development. The ostium primum is normally sealed by fusion of the superior and inferior endocardial cushions around 5 weeks' gestation. Ostium primum defects result from a failure of the fusion of the embryologic endocardial cushion and septum primum.
http://purl.obolibrary.org/obo/HP_0010446	Tricuspid stenosis	http://purl.obolibrary.org/obo/HP_0031651	Abnormal tricuspid valve physiology		A narrowing of the orifice of the tricuspid valve of the heart.
http://purl.obolibrary.org/obo/HP_0010447	Anal fistula	http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology		An abnormal connection between the epithelialised surface of the anal canal and the perianal skin.
http://purl.obolibrary.org/obo/HP_0010448	Colonic atresia	http://purl.obolibrary.org/obo/HP_0011100	Intestinal atresia		A developmental defect resulting in complete obliteration of the lumen of the colon. That is, there is an abnormal closure, or atresia of the tubular structure of the colon.
http://purl.obolibrary.org/obo/HP_0010452	Ectopia of the spleen	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		An abnormal (non-anatomic) location of the spleen.
http://purl.obolibrary.org/obo/HP_0010453	Pelvic bone asymmetry	http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology		Pelvic asymmetry refers to asymmetric positioning of landmarks on the two sides of the pelvis and may have a structural or functional etiology.
http://purl.obolibrary.org/obo/HP_0010454	Acetabular spurs	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		The presence of osteophytes (bone spurs), i.e., of bony projections originating from the acetabulum.
http://purl.obolibrary.org/obo/HP_0010455	Steep acetabular roof	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		An exaggeration of the normal arched form of the acetabular roof such that it takes on a steep appearance.
http://purl.obolibrary.org/obo/HP_0010458	Female pseudohermaphroditism	http://purl.obolibrary.org/obo/HP_0000055	Abnormal female external genitalia morphology		Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In female pseudohermaphroditism, the genotype is female (XX) and the gonads are ovaries, but the external genitalia are virilized.
http://purl.obolibrary.org/obo/HP_0010459	True hermaphroditism	http://purl.obolibrary.org/obo/HP_0000062	Ambiguous genitalia		The presence of both ovarian and testicular tissues either in the same or in opposite gonads. Affected persons have ambiguous genitalia and may have 46,XX or 46,XY karyotypes or 46,XX/XY mosaicism.
http://purl.obolibrary.org/obo/HP_0010462	Aplasia/Hypoplasia of the ovary	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		Aplasia or developmental hypoplasia of the ovary.
http://purl.obolibrary.org/obo/HP_0010463	Aplasia of the ovary	http://purl.obolibrary.org/obo/HP_0010462	Aplasia/Hypoplasia of the ovary		Aplasia, that is failure to develop, of the ovary.
http://purl.obolibrary.org/obo/HP_0010464	Streak ovary	http://purl.obolibrary.org/obo/HP_0008724	Hypoplasia of the ovary		A developmental disorder characterized by the progressive loss of primordial germ cells in the developing ovaries of an embryo, leading to hypoplastic ovaries composed of wavy connective tissue with occasional clumps of granulosa cells, and frequently mesonephric or hilar cells.
http://purl.obolibrary.org/obo/HP_0010465	Precocious puberty in females	http://purl.obolibrary.org/obo/HP_0000826	Precocious puberty		The onset of puberty before the age of 8 years in girls.
http://purl.obolibrary.org/obo/HP_0010468	Aplasia/Hypoplasia of the testes	http://purl.obolibrary.org/obo/HP_0045058	Abnormality of the testis size		Absence or underdevelopment of the testes.
http://purl.obolibrary.org/obo/HP_0010469	Absent testis	http://purl.obolibrary.org/obo/HP_0010468	Aplasia/Hypoplasia of the testes		Testis not palpable in the scrotum or inguinal canal.
http://purl.obolibrary.org/obo/HP_0010470	Supernumerary testes	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		The presence of more than two testes.
http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		Increased urinary excretion of oligosaccharides (low molecular weight carbohydrate chains composed of at least three monosaccharide subunits), derived from a partial degradation of glycoproteins.
http://purl.obolibrary.org/obo/HP_0010473	Porphyrinuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Abnormally increased excretion of porphyrins in the urine.
http://purl.obolibrary.org/obo/HP_0010474	Bladder stones	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Buildups of minerals that form in the urinary bladder.
http://purl.obolibrary.org/obo/HP_0010475	Cloacal exstrophy	http://purl.obolibrary.org/obo/HP_0012620	Cloacal abnormality		Cloacal exstrophy is a severe anterior abdominal wall defect in which the two hemibladders are visible and are separated by a midline intestinal plate, an omphalocele, and an imperforate anus.
http://purl.obolibrary.org/obo/HP_0010476	Aplasia/Hypoplasia of the bladder	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Absence or underdevelopment of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0010477	Aplasia of the bladder	http://purl.obolibrary.org/obo/HP_0010476	Aplasia/Hypoplasia of the bladder		Aplasia (absence) of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0010478	Abnormality of the urachus	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Abnormality of the urachus.
http://purl.obolibrary.org/obo/HP_0010479	Patent urachus	http://purl.obolibrary.org/obo/HP_0010478	Abnormality of the urachus		Persistence of the urachal canal resulting in a canal between the bladder and the umbilicus.
http://purl.obolibrary.org/obo/HP_0010480	Urethral fistula	http://purl.obolibrary.org/obo/HP_0100589	Urogenital fistula		The presence of an abnormal connection between the urethra and another organ or the skin.
http://purl.obolibrary.org/obo/HP_0010481	Urethral valve	http://purl.obolibrary.org/obo/HP_0000796	Urethral obstruction		The presence of an abnormal membrane obstructing the urethra.
http://purl.obolibrary.org/obo/HP_0010482	Acromelia of the upper limbs	http://purl.obolibrary.org/obo/HP_0010884	Acromelia		Shortening of the arms predominantly affecting terminal parts of the arm in relation to the upper and middle limb segments.
http://purl.obolibrary.org/obo/HP_0010483	Amniotic constriction rings of arms	http://purl.obolibrary.org/obo/HP_0009775	Amniotic constriction ring		Amniotic constriction rings affecting the arms.
http://purl.obolibrary.org/obo/HP_0010484	Hypertrophy of the upper limb	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		Abnormal increase in size of the upper limbs (due to an increase of the size of cells).
http://purl.obolibrary.org/obo/HP_0010485	Hyperextensibility at elbow	http://purl.obolibrary.org/obo/HP_0430046	Small joint hypermobility		The ability of the elbow joint to move beyond its normal range of motion.
http://purl.obolibrary.org/obo/HP_0010486	Abnormality of the hypothenar eminence	http://purl.obolibrary.org/obo/HP_0001421	Abnormality of the musculature of the hand		An abnormality of the hypothenar eminence, i.e., of the muscles on the ulnar side of the palm of the hand (i.e., on the side of the little finger).
http://purl.obolibrary.org/obo/HP_0010487	Small hypothenar eminence	http://purl.obolibrary.org/obo/HP_0010486	Abnormality of the hypothenar eminence		Reduced muscle mass on the ulnar side of the palm, that is, reduction in size of the hypothenar eminence.
http://purl.obolibrary.org/obo/HP_0010488	Aplasia/Hypoplasia of the palmar creases	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		Absence or underdevelopment of the palmar creases.
http://purl.obolibrary.org/obo/HP_0010489	Absent palmar crease	http://purl.obolibrary.org/obo/HP_0010488	Aplasia/Hypoplasia of the palmar creases		The absence of the major creases of the palm (distal transverse crease, proximal transverse crease, or thenar crease).
http://purl.obolibrary.org/obo/HP_0010491	Digital constriction ring	http://purl.obolibrary.org/obo/HP_0009775	Amniotic constriction ring		A narrow segment of significantly reduced circumference of a digit.
http://purl.obolibrary.org/obo/HP_0010492	Osseous finger syndactyly	http://purl.obolibrary.org/obo/HP_0006101	Finger syndactyly		Webbing or fusion of the fingers, involving soft parts and including fusion of individual finger bones.
http://purl.obolibrary.org/obo/HP_0010493	Long metacarpals	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		An abnormally increased length of the metacarpal bones.
http://purl.obolibrary.org/obo/HP_0010494	Acromelia of the lower limbs	http://purl.obolibrary.org/obo/HP_0006493	Aplasia/hypoplasia involving bones of the lower limbs		Shortening of the legs predominantly affecting terminal parts of the leg in relation to the upper and middle arm segments.
http://purl.obolibrary.org/obo/HP_0010495	Amniotic constriction rings of legs	http://purl.obolibrary.org/obo/HP_0009775	Amniotic constriction ring		Amniotic constriction rings affecting the legs.
http://purl.obolibrary.org/obo/HP_0010496	Hypertrophy of the lower limb	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		Abnormal increase in size of the lower limbs (due to an increase of the size of cells).
http://purl.obolibrary.org/obo/HP_0010497	Sirenomelia	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		A developmental defect in which the legs are fused together.
http://purl.obolibrary.org/obo/HP_0010498	Bipartite patella	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		A developmental defect that occurs if the two halves of the patella fail to fuse in early childhood.
http://purl.obolibrary.org/obo/HP_0010499	Patellar subluxation	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar subluxation refers to an unstable kneecap that does not slide centrally within its groove, i.e., a partial dislocation of the patella.
http://purl.obolibrary.org/obo/HP_0010500	Hyperextensibility of the knee	http://purl.obolibrary.org/obo/HP_0034670	Abnormal knee physiology		The ability of the knee joint to extend beyond its normal range of motion (the lower leg is moved beyond a straight position with respect to the thigh).
http://purl.obolibrary.org/obo/HP_0010501	Limitation of knee mobility	http://purl.obolibrary.org/obo/HP_0034670	Abnormal knee physiology		An abnormal limitation of knee joint mobility.
http://purl.obolibrary.org/obo/HP_0010502	Fibular bowing	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		A bending or abnormal curvature of the fibula.
http://purl.obolibrary.org/obo/HP_0010503	Fibular duplication	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		Duplication of the fibula. This may occur as a part of diplopodia (accessory tarsal or metatarsal bone). Diplopodia with double fibula is an extremely rare condition.
http://purl.obolibrary.org/obo/HP_0010504	Increased length of the tibia	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		An abnormal increase in the length of the tibia.
http://purl.obolibrary.org/obo/HP_0010505	Limitation of movement at ankles	http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology		An abnormal limitation of the mobility of the ankle joint.
http://purl.obolibrary.org/obo/HP_0010506	Abnormal plantar dermatoglyphics	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		An abnormality of dermatoglyphs on the toes and soles, i.e., an abnormality of the patterns of ridges of the skin of sole of foot.
http://purl.obolibrary.org/obo/HP_0010507	Foot asymmetry	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		A difference in size or shape between the left and right foot.
http://purl.obolibrary.org/obo/HP_0010508	Metatarsus valgus	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		A condition in which the anterior part of the foot rotates outward away from the midline of the body and the heel remains straight.
http://purl.obolibrary.org/obo/HP_0010509	Aplasia of the tarsal bones	http://purl.obolibrary.org/obo/HP_0008363	Aplasia/Hypoplasia of the tarsal bones		Absence of the tarsal bones.
http://purl.obolibrary.org/obo/HP_0010510	Hypermobility of toe joints	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		An ability of the toe joints to move beyond their normal range of motion.
http://purl.obolibrary.org/obo/HP_0010512	Adrenal calcification	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Calcification within the adrenal glands.
http://purl.obolibrary.org/obo/HP_0010513	Pituitary calcification	http://purl.obolibrary.org/obo/HP_0430048	Intracranial calcification		Deposition of calcium salts in the pituitary gland.
http://purl.obolibrary.org/obo/HP_0010516	Thymus hyperplasia	http://purl.obolibrary.org/obo/HP_0000777	Abnormal thymus morphology		Enlargement of the thymus.
http://purl.obolibrary.org/obo/HP_0010517	Ectopic thymus tissue	http://purl.obolibrary.org/obo/HP_0000777	Abnormal thymus morphology		The presence of ectopic thymus tissue. Normally, cells of the ventral bud of the third pharyngeal pouch detach and migrate in the eighth gestational week caudally and medially towards the location of the mature thyroid. They migrate further retrosternally into the superior mediastinum. There are two main ways ectopic thymus tissue can develop. Either cells detach along the descensus path and proliferate, thereby forming accessory thymus tissue, or the entire gland fails to descend.
http://purl.obolibrary.org/obo/HP_0010518	Thyroglossal cyst	http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology		An abnormality of the thyroid gland owing to the presence of a fibrous cyst resulting from the persistence of the thyroglossal duct.
http://purl.obolibrary.org/obo/HP_0010519	Increased fetal movement	http://purl.obolibrary.org/obo/HP_0001557	Prenatal movement abnormality		An abnormal increase in quantity or strength of fetal movements.
http://purl.obolibrary.org/obo/HP_0010521	Gait apraxia	http://purl.obolibrary.org/obo/HP_0002186	Apraxia		Gait apraxia affecting the ability to make walking movements with the legs.
http://purl.obolibrary.org/obo/HP_0010522	Dyslexia	http://purl.obolibrary.org/obo/HP_0001328	Specific learning disability		A learning disorder characterized primarily by difficulties in learning to read and spell. Dyslectic children also exhibit a tendency to read words from right to left and to confuse letters such as b and d whose orientation is important for their identification. Children with dyslexia appear to be impaired in phonemic skills (the ability to associate visual symbols with the sounds they represent).
http://purl.obolibrary.org/obo/HP_0010523	Alexia	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		An acquired type of sensory aphasia where damage to the brain leads to the loss of the ability to read.
http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception	http://purl.obolibrary.org/obo/HP_5200204	Disturbed perception with a stimulus		Alteration or impairment in the processing or interpretation of sensory information can lead to abnormal perceptions or experiences.
http://purl.obolibrary.org/obo/HP_0010525	Finger agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The examiner identified the inability to name, move, or touch specific fingers.
http://purl.obolibrary.org/obo/HP_0010526	Dysgraphia	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		A writing disability in the absence of motor or sensory deficits of the upper extremities, resulting in an impairment in the ability to write regardless of the ability to read and not due to intellectual impairment.
http://purl.obolibrary.org/obo/HP_0010527	Astereognosis	http://purl.obolibrary.org/obo/HP_5200406	Tactile agnosia		Tactile agnosia refers to the inability to recognize objects by touch, while the inability to discriminate shape and size by touch is also a related condition.
http://purl.obolibrary.org/obo/HP_0010528	Prosopagnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		Inability to recognize faces of familiar persons.
http://purl.obolibrary.org/obo/HP_0010529	Echolalia	http://purl.obolibrary.org/obo/HP_4000074	Involuntary vocalization		Echolalia is the automatic imitative repetition of sounds, words, or phrases in the absence of explicit awareness. The repeated words or phrases are typically odd or used in a non-social manner. These can be words or phrases that the affected individual has heard or invented.
http://purl.obolibrary.org/obo/HP_0010530	Palatal tremor	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		Palatal tremor (PT) is an involuntary, rhythmic and oscillatory movement of the soft palate. PT is a rare type of tremor involving the soft palate. It can be unilateral or bilateral.
http://purl.obolibrary.org/obo/HP_0010531	Spinal myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		Spinal myoclonus is generally due to a tumor, infection, injury, or degenerative process of the spinal cord, and is characterized by involuntary rhythmic muscle contractions, usually at a rate of more than one per second. Myoclonus occurs synchronously in several muscles and can be increased in severity and frequency by fatigue or stress, but is usually unaffected by sensory stimuli. Spinal myoclonus ceases during sleep or anesthesia.
http://purl.obolibrary.org/obo/HP_0010532	Paroxysmal vertigo	http://purl.obolibrary.org/obo/HP_0002321	Vertigo		Paroxysmal episodes of vertigo.
http://purl.obolibrary.org/obo/HP_0010533	Spasmus nutans	http://purl.obolibrary.org/obo/HP_0012043	Pendular nystagmus		The combination of pendular nystagmus, head nodding, and torticollis.
http://purl.obolibrary.org/obo/HP_0010534	Transient global amnesia	http://purl.obolibrary.org/obo/HP_0002354	Memory impairment		A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information.
http://purl.obolibrary.org/obo/HP_0010536	Central sleep apnea	http://purl.obolibrary.org/obo/HP_0010535	Sleep apnea		Sleep apnea results from a temporary loss of the central drive to the muscles responsible for breathing.
http://purl.obolibrary.org/obo/HP_0010537	Wide cranial sutures	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		An abnormally increased width of the cranial sutures for age-related norms (generally resulting from delayed closure).
http://purl.obolibrary.org/obo/HP_0010538	Small sella turcica	http://purl.obolibrary.org/obo/HP_0002679	Abnormal sella turcica morphology		An abnormally small sella turcica.
http://purl.obolibrary.org/obo/HP_0010539	Thin calvarium	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		The presence of an abnormally thin calvarium.
http://purl.obolibrary.org/obo/HP_0010540	Advanced pneumatization of cranial sinuses	http://purl.obolibrary.org/obo/HP_0000245	Abnormal paranasal sinus morphology		A degree of pneumatization that is increased compared to age-related norms.
http://purl.obolibrary.org/obo/HP_0010541	Cutis gyrata of scalp	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		The presence of convoluted folds and furrows formed from thickened skin of the scalp, resembling cerebriform pattern. The scalp has convoluted and elevated folds, 1 to 2 cm in thickness. The convolutions generally cannot be flattened by traction.
http://purl.obolibrary.org/obo/HP_0010542	Vestibular nystagmus	http://purl.obolibrary.org/obo/HP_0031910	Abnormal cranial nerve physiology		Nystagmus due to disturbance of the vestibular system; eye movements are rhythmic, with slow and fast components.
http://purl.obolibrary.org/obo/HP_0010543	Opsoclonus	http://purl.obolibrary.org/obo/HP_0032104	Saccadic oscillation		Bursts of large-amplitude multidirectional saccades without intersaccadic interval
http://purl.obolibrary.org/obo/HP_0010544	Vertical nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		Vertical nystagmus may present with either up-beating or down-beating eye movements or both. When present in the straight-ahead position of gaze it is referred to as upbeat nystagmus or downbeat nystagmus.
http://purl.obolibrary.org/obo/HP_0010545	Downbeat nystagmus	http://purl.obolibrary.org/obo/HP_0010544	Vertical nystagmus		Downbeat nystagmus is a type of fixation nystagmus with the fast phase beating in a downward direction. It generally increases when looking to the side and down and when lying prone.
http://purl.obolibrary.org/obo/HP_0010553	Oculogyric crisis	http://purl.obolibrary.org/obo/HP_0001332	Dystonia		An acute dystonic reaction with blepharospasm, periorbital twitches, and protracted fixed staring episodes. There may be a maximal upward deviation of the eyes in the sustained fashion. Oculogyric crisis can be triggered by a number of factors including neuroleptic medications.
http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly	http://purl.obolibrary.org/obo/HP_0012725	Cutaneous syndactyly		A soft tissue continuity in the A/P axis between two fingers that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two fingers that lies significantly distal to the flexion crease that overlies the metacarpophalangeal joint of the adjacent fingers.
http://purl.obolibrary.org/obo/HP_0010557	Overlapping fingers	http://purl.obolibrary.org/obo/HP_0004097	Deviation of finger		A finger resting on the dorsal surface of an adjacent digit when the hand is at rest.
http://purl.obolibrary.org/obo/HP_0010558	Abnormality of the clivus	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		An abnormality of the clivus, which is the inclined bony region of the posterior cranial fossa located between the sella turcica and the foramen magnum.
http://purl.obolibrary.org/obo/HP_0010559	Vertical clivus	http://purl.obolibrary.org/obo/HP_0010558	Abnormality of the clivus		An abnormal vertical orientation of the clivus (which normally forms a kind of slope from the sella turcica down to the region of the foramen magnum).
http://purl.obolibrary.org/obo/HP_0010560	Undulate clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		An abnormally wavy surface or edge of the clavicles.
http://purl.obolibrary.org/obo/HP_0010561	Undulate ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		An abnormally wavy surface or edge of the ribs.
http://purl.obolibrary.org/obo/HP_0010564	Bifid epiglottis	http://purl.obolibrary.org/obo/HP_0005483	Abnormal epiglottis morphology		A midline anterior-posterior cleft of the epiglottis that involves at least two-thirds of the epiglottic leaf. It is a useful feature for clinical diagnosis because it appears to be very rare in syndromes other than Pallister-Hall-Syndrome and is also rare as an isolated malformation.
http://purl.obolibrary.org/obo/HP_0010565	Aplasia/Hypoplasia of the Epiglottis	http://purl.obolibrary.org/obo/HP_0005483	Abnormal epiglottis morphology		This term applies if the Epiglottis is absent or hypoplastic.
http://purl.obolibrary.org/obo/HP_0010567	Y-shaped metatarsals	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		Y-shaped metatarsals are the result of a partial fusion of two metatarsal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metatarsals may be seen in combination with polydactyly.
http://purl.obolibrary.org/obo/HP_0010568	Hamartoma of the eye	http://purl.obolibrary.org/obo/HP_0100012	Neoplasm of the eye		A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the eye.
http://purl.obolibrary.org/obo/HP_0010569	Elevated circulating 7-dehydrocholesterol concentration	http://purl.obolibrary.org/obo/HP_0034934	Abnormal circulating 7-dehydrocholesterol concentration		Concentration of 7-dehydrocholesterol in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0010570	Low maternal circulating alpha-fetoprotein concentration	http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening		An abnormally low concentration of serum alpha-fetoprotein as compared to normal values for gestational-age.
http://purl.obolibrary.org/obo/HP_0010571	Elevated circulating phytanic acid concentration	http://purl.obolibrary.org/obo/HP_0010965	Abnormal circulating phytanic acid concentration		An abnormal elevation of phytanic acid.
http://purl.obolibrary.org/obo/HP_0010575	Dysplasia of the femoral head	http://purl.obolibrary.org/obo/HP_0003368	Abnormal femoral head morphology		The presence of developmental dysplasia of the femoral head.
http://purl.obolibrary.org/obo/HP_0010579	Cone-shaped epiphysis	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery.
http://purl.obolibrary.org/obo/HP_0010583	Ivory epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Sclerosis of the epiphyses, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.
http://purl.obolibrary.org/obo/HP_0010587	Triangular epiphysis	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Longitudinal epiphyseal bracket or bracket epiphysis is an uncommon disorder of growth. Alternatively known as a delta phalanx, it is due to an anomalous secondary ossification center that extends longitudinally along the diaphysis. Although rare, longitudinal epiphyseal bracket most commonly manifests in the hands as clinodactyly and in the feet as hallux varus.
http://purl.obolibrary.org/obo/HP_0010588	Premature epimetaphyseal fusion	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at each end of a long bone, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.
http://purl.obolibrary.org/obo/HP_0010590	Abnormality of the distal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0006499	Abnormal femoral epiphysis morphology		Any abnormality of the distal epiphysis of the femur.
http://purl.obolibrary.org/obo/HP_0010591	Abnormality of the proximal tibial epiphysis	http://purl.obolibrary.org/obo/HP_0006508	Abnormality of tibial epiphyses		Any abnormality of the proximal epiphysis of the tibia.
http://purl.obolibrary.org/obo/HP_0010594	Abnormality of the proximal fibular epiphysis	http://purl.obolibrary.org/obo/HP_0010593	Abnormal fibular epiphysis morphology		Any abnormality of the proximal epiphysis of the fibula.
http://purl.obolibrary.org/obo/HP_0010595	Abnormality of the distal fibular epiphysis	http://purl.obolibrary.org/obo/HP_0010593	Abnormal fibular epiphysis morphology		Any abnormality of the distal epiphysis of the fibula.
http://purl.obolibrary.org/obo/HP_0010596	Abnormal proximal radial epiphysis morphology	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		Any abnormality of the proximal epiphysis of the radius.
http://purl.obolibrary.org/obo/HP_0010597	Abnormality of the distal radial epiphysis	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		Any abnormality of the distal epiphysis of the radius.
http://purl.obolibrary.org/obo/HP_0010598	Abnormality of the proximal humeral epiphysis	http://purl.obolibrary.org/obo/HP_0003891	Abnormal humeral epiphysis morphology		Any abnormality of the proximal epiphysis of the humerus.
http://purl.obolibrary.org/obo/HP_0010599	Abnormal distal humeral epiphysis morphology	http://purl.obolibrary.org/obo/HP_0003946	Abnormal elbow epiphysis morphology		Any abnormality of the distal epiphysis of the humerus.
http://purl.obolibrary.org/obo/HP_0010600	Abnormal distal ulnar epiphysis morphology	http://purl.obolibrary.org/obo/HP_0004037	Abnormal ulnar epiphysis morphology		Any abnormality of the distal epiphysis of the ulna.
http://purl.obolibrary.org/obo/HP_0010601	Abnormal proximal ulnar epiphysis morphology	http://purl.obolibrary.org/obo/HP_0004037	Abnormal ulnar epiphysis morphology		Any abnormality of the proximal epiphysis of the ulna.
http://purl.obolibrary.org/obo/HP_0010602	Type 2 muscle fiber predominance	http://purl.obolibrary.org/obo/HP_0033684	Abnormal muscle fiber-type distribution		An abnormal predominance of type II muscle fibers (in general, this feature can only be observed on muscle biopsy).
http://purl.obolibrary.org/obo/HP_0010603	Odontogenic keratocysts of the jaw	http://purl.obolibrary.org/obo/HP_0100612	Odontogenic neoplasm		A benign uni- or multicystic, intraosseous tumor of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behavior.
http://purl.obolibrary.org/obo/HP_0010605	Chalazion	http://purl.obolibrary.org/obo/HP_0010604	Cyst of the eyelid		A chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland. A chalazion or meibomian cyst appears as a painless tuberous swelling in the upper lid without loss of eyelashes.
http://purl.obolibrary.org/obo/HP_0010607	Hordeolum externum	http://purl.obolibrary.org/obo/HP_0010606	Hordeolum		Hordeola externa are acute purulent infections affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll, often caused by staphylococcus infections. In contrast to chalazia, hordeola are extremely painfull and can cause extreme local swelling.
http://purl.obolibrary.org/obo/HP_0010608	Hordeolum internum	http://purl.obolibrary.org/obo/HP_0010606	Hordeolum		Hordeola interna are acute purulent infections affecting the meibomian sebacious glands, often caused by staphylococcus infections. In contrast to chalazia (chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland), hordeola are extremely painfull and can cause extreme local swelling.
http://purl.obolibrary.org/obo/HP_0010612	Plantar pits	http://purl.obolibrary.org/obo/HP_0100276	Skin pit		The presence of multiple pits (small, pinpoint-large indentations on the surface of the skin) located on the skin of sole of foot.
http://purl.obolibrary.org/obo/HP_0010615	Angiofibromas	http://purl.obolibrary.org/obo/HP_0010614	Fibroma		Angiofibroma consist of many often dilated vessels.
http://purl.obolibrary.org/obo/HP_0010616	Lung fibroma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		The presence of a lung fibroma, a benign neoplasm that can present as a mass causing airway obstruction, cough, and hemoptysis, or present without symptoms as a solitary pulmonary nodule.
http://purl.obolibrary.org/obo/HP_0010617	Cardiac fibroma	http://purl.obolibrary.org/obo/HP_0100544	Neoplasm of the heart		A fibroma of the heart.
http://purl.obolibrary.org/obo/HP_0010618	Ovarian fibroma	http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm		The presence of a fibroma of the ovary.
http://purl.obolibrary.org/obo/HP_0010619	Fibroadenoma of the breast	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		A benign biphasic tumor of the breast with epithelial and stromal components.
http://purl.obolibrary.org/obo/HP_0010620	Malar prominence	http://purl.obolibrary.org/obo/HP_0010668	Abnormal zygomatic bone morphology		Prominence of the malar process of the maxilla and infraorbital area appreciated in profile and from in front of the face.
http://purl.obolibrary.org/obo/HP_0010621	Cutaneous syndactyly of toes	http://purl.obolibrary.org/obo/HP_0012725	Cutaneous syndactyly		A soft tissue continuity in the anteroposterior axis between adjacent foot digits that involves at least half of the proximodistal length of one of the two involved digits; or, a soft tissue continuity in the A/P axis between two digits of the foot that does not meet the prior objective criteria.
http://purl.obolibrary.org/obo/HP_0010625	Anterior pituitary dysgenesis	http://purl.obolibrary.org/obo/HP_0011747	Abnormality of the anterior pituitary		Absence or underdevelopment of the anterior pituitary gland, also known as the adenohypophysis.
http://purl.obolibrary.org/obo/HP_0010626	Anterior pituitary agenesis	http://purl.obolibrary.org/obo/HP_0010625	Anterior pituitary dysgenesis		Absence of the anterior pituitary gland resulting from a developmental defect.
http://purl.obolibrary.org/obo/HP_0010627	Anterior pituitary hypoplasia	http://purl.obolibrary.org/obo/HP_0010625	Anterior pituitary dysgenesis		Underdevelopment of the anterior pituitary gland.
http://purl.obolibrary.org/obo/HP_0010630	Abnormal metatarsal epiphysis morphology	http://purl.obolibrary.org/obo/HP_0010631	Abnormality of the epiphyses of the feet		Any abnormality of a metatarsal bone epiphysis.
http://purl.obolibrary.org/obo/HP_0010631	Abnormality of the epiphyses of the feet	http://purl.obolibrary.org/obo/HP_0006500	Abnormal lower limb epiphysis morphology		Any abnormality of the epiphyses of the feet.
http://purl.obolibrary.org/obo/HP_0010632	Total anosmia	http://purl.obolibrary.org/obo/HP_0000458	Anosmia		Inability to detect any qualitative olfactory sensation.
http://purl.obolibrary.org/obo/HP_0010633	Partial anosmia	http://purl.obolibrary.org/obo/HP_0000458	Anosmia		Inability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants).
http://purl.obolibrary.org/obo/HP_0010634	Total hyposmia	http://purl.obolibrary.org/obo/HP_0004409	Hyposmia		Reduced ability to detect any qualitative olfactory sensation.
http://purl.obolibrary.org/obo/HP_0010635	Partial hyposmia	http://purl.obolibrary.org/obo/HP_0004409	Hyposmia		Reduced ability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants).
http://purl.obolibrary.org/obo/HP_0010636	Schizencephaly	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		The presence of a cleft in the cerebral cortex unilaterally or bilaterally, usually located in the frontal area.
http://purl.obolibrary.org/obo/HP_0010637	Conjunctival amyloidosis	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		A form of amyloidosis that affects the conjunctiva.
http://purl.obolibrary.org/obo/HP_0010638	Elevated alkaline phosphatase of hepatic origin	http://purl.obolibrary.org/obo/HP_0010679	Elevated tissue non-specific alkaline phosphatase		An abnormally increased level of liver isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood.
http://purl.obolibrary.org/obo/HP_0010639	Elevated alkaline phosphatase of bone origin	http://purl.obolibrary.org/obo/HP_0010679	Elevated tissue non-specific alkaline phosphatase		An abnormally increased level of bone isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood.
http://purl.obolibrary.org/obo/HP_0010640	Abnormal nasal cavity morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Abnormality of the nasal cavity (the cavity includes and starts at the nares and reaches all the way through to the and includes the choanae, the posterior nasal apertures).
http://purl.obolibrary.org/obo/HP_0010641	Abnormality of the midnasal cavity	http://purl.obolibrary.org/obo/HP_0010640	Abnormal nasal cavity morphology		Abnormality of the midnasal cavity which includes the cavity between the nares and the choanae.
http://purl.obolibrary.org/obo/HP_0010643	Midnasal atresia	http://purl.obolibrary.org/obo/HP_0010644	Midnasal stenosis		Absence or abnormal closure of the midnasal cavity.
http://purl.obolibrary.org/obo/HP_0010644	Midnasal stenosis	http://purl.obolibrary.org/obo/HP_0010641	Abnormality of the midnasal cavity		Abnormal narrowing (stenosis) of the midnasal cavity, i.e., of the middle nasal meatus, which in neonates can cause respiratory distress.
http://purl.obolibrary.org/obo/HP_0010645	Aplasia of the distal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		Absence of the distal phalanges of the toes.
http://purl.obolibrary.org/obo/HP_0010646	Cervical spine instability	http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine		An abnormal lack of stability of the cervical spine.
http://purl.obolibrary.org/obo/HP_0010648	Dermal translucency	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		An abnormally increased ability of the skin to permit light to pass through (translucency) such that subcutaneous structures such as veins display an increased degree of visibility.
http://purl.obolibrary.org/obo/HP_0010649	Flat nasal alae	http://purl.obolibrary.org/obo/HP_0000429	Abnormal morphology of the nasal alae		An abnormal degree of flatness of the Ala of nose, which can be defined as a reduced nasal elevation index (lateral depth of the nose from the tip of the nose to the insertion of the nasal ala in the cheek x 100 divided by the side-to-side breadth of the nasal alae).
http://purl.obolibrary.org/obo/HP_0010650	Hypoplasia of the premaxilla	http://purl.obolibrary.org/obo/HP_0010756	Aplasia/Hypoplasia of the premaxilla		An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively small in size compared to the other parts of the maxilla or other facial structures.
http://purl.obolibrary.org/obo/HP_0010652	Abnormal dura mater morphology	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		An abnormality of the Dura mater.
http://purl.obolibrary.org/obo/HP_0010653	Abnormality of the falx cerebri	http://purl.obolibrary.org/obo/HP_0010652	Abnormal dura mater morphology		An abnormality of the Falx cerebri.
http://purl.obolibrary.org/obo/HP_0010654	Aplasia of the falx cerebri	http://purl.obolibrary.org/obo/HP_0010653	Abnormality of the falx cerebri		A developmental defect characterized by aplasia of the Falx cerebri.
http://purl.obolibrary.org/obo/HP_0010657	Patchy reduction of bone mineral density	http://purl.obolibrary.org/obo/HP_0010658	Patchy changes of bone mineral density		Patchy (irregular) reduction in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0010658	Patchy changes of bone mineral density	http://purl.obolibrary.org/obo/HP_0004348	Abnormality of bone mineral density		Patchy (irregular) changes in bone mineral density. These changes can either be patchy reduction or increase of mineral density as seen on x-rays. Depending on the pathomechanism and the underlying disease, these changes can either appear solely as reduction or increase or as a combination of both (patches of bone showing an increased density while others are affected by reduction of mineral density).
http://purl.obolibrary.org/obo/HP_0010659	Patchy variation in bone mineral density	http://purl.obolibrary.org/obo/HP_0010658	Patchy changes of bone mineral density		Patchy (irregular) changes in bone mineral density with patches of bone showing an increased density side to side with patches that are affected by reduction of mineral density. This is sometimes referred to as a moth-eaten appearance on x-rays.
http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		An abnormality of the formation and mineralization of any bone of the skeleton of hand.
http://purl.obolibrary.org/obo/HP_0010661	Absence of the third cerebral ventricle	http://purl.obolibrary.org/obo/HP_0010951	Abnormal third ventricle morphology		A developmental defect characterized by the absence of the third ventricle.
http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology	http://purl.obolibrary.org/obo/HP_0010662	Abnormal diencephalon morphology		An abnormality of the thalamus.
http://purl.obolibrary.org/obo/HP_0010664	Fusion of the left and right thalami	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		A developmental defect characterized by fusion of the left and right halves of the thalamus.
http://purl.obolibrary.org/obo/HP_0010665	Bilateral coxa valga	http://purl.obolibrary.org/obo/HP_0002673	Coxa valga		The presence of bilateral coxa valga.
http://purl.obolibrary.org/obo/HP_0010666	Hypoplasia of the anterior nasal spine	http://purl.obolibrary.org/obo/HP_0000327	Hypoplasia of the maxilla		Underdevelopment of the anterior nasal spine of maxilla.
http://purl.obolibrary.org/obo/HP_0010667	Aplasia of the maxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		A congenital defect characterized by absence of the Maxilla.
http://purl.obolibrary.org/obo/HP_0010668	Abnormal zygomatic bone morphology	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		An abnormality of the zygomatic bone.
http://purl.obolibrary.org/obo/HP_0010669	Hypoplasia of the zygomatic bone	http://purl.obolibrary.org/obo/HP_0010668	Abnormal zygomatic bone morphology		Underdevelopment of the zygomatic bone. That is, a reduction in size of the zygomatic bone, including the zygomatic process of the temporal bone of the skull, which forms part of the zygomatic arch.
http://purl.obolibrary.org/obo/HP_0010672	Abnormality of the third metatarsal bone	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		An abnormality of the third metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010675	Abnormal foot bone ossification	http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification		An abnormality of the formation and mineralization of any bone of the skeleton of foot.
http://purl.obolibrary.org/obo/HP_0010677	Enuresis nocturna	http://purl.obolibrary.org/obo/HP_0000805	Enuresis		Enuresis occurring during sleeping hours.
http://purl.obolibrary.org/obo/HP_0010678	Enuresis diurna	http://purl.obolibrary.org/obo/HP_0000805	Enuresis		Enuresis occurring during waking hours of the day.
http://purl.obolibrary.org/obo/HP_0010679	Elevated tissue non-specific alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003155	Elevated circulating alkaline phosphatase concentration		An abnormally increased level of alkaline phosphatase, tissue-nonspecific isozyme in the blood.
http://purl.obolibrary.org/obo/HP_0010680	Elevated alkaline phosphatase of renal origin	http://purl.obolibrary.org/obo/HP_0010679	Elevated tissue non-specific alkaline phosphatase		An abnormally increased level of kidney isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood.
http://purl.obolibrary.org/obo/HP_0010681	Elevated intestinal alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003155	Elevated circulating alkaline phosphatase concentration		An abnormally increased level of alkaline phosphatase, intestinal type in the blood.
http://purl.obolibrary.org/obo/HP_0010682	Elevated placental alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003155	Elevated circulating alkaline phosphatase concentration		An abnormally increased level of alkaline phosphatase, placental type in the blood.
http://purl.obolibrary.org/obo/HP_0010683	Low tissue non-specific alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity		An abnormally reduced level of alkaline phosphatase, tissue-nonspecific isozyme in the blood.
http://purl.obolibrary.org/obo/HP_0010684	Low alkaline phosphatase of bone origin	http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity		An abnormally reduced level of bone isoforms of alkaline phosphatase in the blood.
http://purl.obolibrary.org/obo/HP_0010685	Low alkaline phosphatase of renal origin	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		An abnormally reduced level of kidney isoforms of alkaline phosphatase in the blood.
http://purl.obolibrary.org/obo/HP_0010686	Low alkaline phosphatase of hepatic origin	http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity		An abnormally reduced level of liver isoforms of alkaline phosphatase in the blood.
http://purl.obolibrary.org/obo/HP_0010687	Low intestinal alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity		An abnormally reduced level of alkaline phosphatase, intestinal type in the blood.
http://purl.obolibrary.org/obo/HP_0010688	Low placental alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity		An abnormally reduced level of alkaline phosphatase, placental type in the blood.
http://purl.obolibrary.org/obo/HP_0010689	Mirror image polydactyly	http://purl.obolibrary.org/obo/HP_0010442	Polydactyly		A hand or foot with more than five digits that has a recognizable A/P axis of symmetry. The axis can lie within a normally formed or partially duplicated digit resembling a middle finger, index finger, thumb, toe, or hallux. Alternatively, the axis can be in an interdigital space with a flanking pair of digits that resemble a middle finger, index finger, thumb, toe or hallux. The most lateral digits on each side of the hand/foot typically resemble fifth fingers/toes.
http://purl.obolibrary.org/obo/HP_0010690	Mirror image hand polydactyly	http://purl.obolibrary.org/obo/HP_0010689	Mirror image polydactyly		Mirror image duplication of digits affecting the hands only.
http://purl.obolibrary.org/obo/HP_0010691	Mirror image foot polydactyly	http://purl.obolibrary.org/obo/HP_0010689	Mirror image polydactyly		Mirror image duplication of digits affecting the feet.
http://purl.obolibrary.org/obo/HP_0010693	Pulverulent cataract	http://purl.obolibrary.org/obo/HP_0007648	Punctate cataract		A kind of congenital cataract that is characterized by a hollow sphere of punctate opacities involving the fetal nucleus and that usually occurs bilaterally.
http://purl.obolibrary.org/obo/HP_0010694	Lamellar pulverulent cataract	http://purl.obolibrary.org/obo/HP_0007971	Lamellar cataract		A Lamellar cataract with a pulverulent (punctate, "dust-like" opacities) appearance.
http://purl.obolibrary.org/obo/HP_0010695	Sutural cataract	http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract		A type of congenital cataract in which the opacity follows the anterior or posterior Y suture.
http://purl.obolibrary.org/obo/HP_0010697	Anterior pyramidal cataract	http://purl.obolibrary.org/obo/HP_0001134	Anterior polar cataract		A type of anterior polar cataract which projects as a conical opacity into the anterior chamber.
http://purl.obolibrary.org/obo/HP_0010698	Nuclear pulverulent cataract	http://purl.obolibrary.org/obo/HP_0010925	Nuclear punctate cataract		A type of nuclear cataract involving congenital dust-like (pulverulent) opacity of the embryonal and fetal nucleus.
http://purl.obolibrary.org/obo/HP_0010699	Triangular nuclear cataract	http://purl.obolibrary.org/obo/HP_0100018	Nuclear cataract		A nuclear cataract with a triangular form.
http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration	http://purl.obolibrary.org/obo/HP_0005368	Abnormality of humoral immunity		An abnormal deviation from normal levels of immunoglobulins in blood.
http://purl.obolibrary.org/obo/HP_0010704	1-2 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the thumb to the index finger that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0010705	4-5 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the fourth (ring) to the fifth (little) finger that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0010706	1-3 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the thumb to the middle finger that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0010707	1-4 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the thumb to the ring finger that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0010708	1-5 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the thumb to the little finger that extends distally to at least the level of the proximal interphalangeal joints (complete syndactyly of all fingers of the hand).
http://purl.obolibrary.org/obo/HP_0010709	2-4 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the second (index) to the fourth (ring) finger that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0010710	3-5 finger syndactyly	http://purl.obolibrary.org/obo/HP_0010492	Osseous finger syndactyly		A soft tissue continuity in the anteroposterior axis between the middle to little fingers that extends distally to at least the level of the proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0010711	1-2 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes one and two.
http://purl.obolibrary.org/obo/HP_0010712	1-4 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes one to four.
http://purl.obolibrary.org/obo/HP_0010713	1-5 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes one to five (complete syndactyly of all toes of the foot).
http://purl.obolibrary.org/obo/HP_0010714	2-4 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes two to four.
http://purl.obolibrary.org/obo/HP_0010715	2-5 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes two to five.
http://purl.obolibrary.org/obo/HP_0010716	3-5 toe syndactyly	http://purl.obolibrary.org/obo/HP_0001770	Toe syndactyly		Syndactyly with fusion of toes three to five.
http://purl.obolibrary.org/obo/HP_0010717	Osseous syndactyly of toes	http://purl.obolibrary.org/obo/HP_0100235	Toe phalanx synostosis		Webbing or fusion of the toes, involving soft parts and including fusion of individual bones of the toes. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a tibial-fibular axis. Fusions of bones of the toes in a proximo-distal axis are referred to as "Symphalangism".
http://purl.obolibrary.org/obo/HP_0010720	Abnormal hair pattern	http://purl.obolibrary.org/obo/HP_0001595	Abnormal hair morphology		An abnormality of the distribution of hair growth.
http://purl.obolibrary.org/obo/HP_0010722	Asymmetry of the ears	http://purl.obolibrary.org/obo/HP_0000357	Abnormal location of ears		An asymmetriy, i.e., difference in size, shape or position between the left and right ear.
http://purl.obolibrary.org/obo/HP_0010724	Advanced pneumatization of the mastoid process	http://purl.obolibrary.org/obo/HP_0000264	Abnormal mastoid morphology		An abnormally advanced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms.
http://purl.obolibrary.org/obo/HP_0010726	Prominent corneal nerve fibers	http://purl.obolibrary.org/obo/HP_0011492	Abnormal corneal stroma morphology		Abnormal prominence of the corneal nerve fibers.
http://purl.obolibrary.org/obo/HP_0010727	Spontaneous rupture of the globe	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		Rupture of the eyeball not due to trauma.
http://purl.obolibrary.org/obo/HP_0010728	Aplasia of the retina	http://purl.obolibrary.org/obo/HP_0008061	Aplasia/Hypoplasia of the retina		A developmental defect characterized by absence of the retina.
http://purl.obolibrary.org/obo/HP_0010729	Cherry red spot of the macula	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		Pallor of the perifoveal macula of the retina with appearance of a small circular reddish choroid shape as seen through the fovea centralis due to relative transparency of the macula.
http://purl.obolibrary.org/obo/HP_0010730	Double eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		This may present as a partial or complete duplication of the eyebrows.
http://purl.obolibrary.org/obo/HP_0010731	Extension of eyebrows towards upper eyelid	http://purl.obolibrary.org/obo/HP_0011229	Broad eyebrow		The eyebrows extend towards - or even all the way down to - the margin of the upper eyelid.
http://purl.obolibrary.org/obo/HP_0010732	Nodular changes affecting the eyelids	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		Nodular changes affecting the eyelids may have many different causes such as cystic lesions (chalaziae, hordeolae), lipogranulomas, melanomas, infectious diseases (Molluscum contagiosum) and many more.
http://purl.obolibrary.org/obo/HP_0010733	Naevus flammeus of the eyelid	http://purl.obolibrary.org/obo/HP_0001052	Nevus flammeus		Naevus flammeus localized in the skin of the eyelid.
http://purl.obolibrary.org/obo/HP_0010734	Fibrous dysplasia of the bones	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		Tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone or bones may be involved. Fibrous dysplasia can either effect isolated bones (Monostotic fibrous dysplasia) or also generalized all bones of the body (Polyostotic fibrous dysplasia).
http://purl.obolibrary.org/obo/HP_0010735	Polyostotic fibrous dysplasia	http://purl.obolibrary.org/obo/HP_0010734	Fibrous dysplasia of the bones		Fibrous dysplasia of the bones were lesions are localized in many bones throughout of the body. Polyostotic fibrous dysplasia is a cardinal feature of McCune-Albright syndrome.
http://purl.obolibrary.org/obo/HP_0010736	Monostotic fibrous dysplasia	http://purl.obolibrary.org/obo/HP_0010734	Fibrous dysplasia of the bones		Fibrous dysplasia of the bones were lesions are localized in only one bone.
http://purl.obolibrary.org/obo/HP_0010739	Osteopoikilosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		Osteopoikilosis is a benign, asymptomatic sclerotic dysplasia of the bones. It affects both male and female and may be seen at any age. Radiographically sclerotic circular or ovoid lesions are usually symmetrically distributed in a periarticular location. Lesions can increase or decrease in size and number in serial radiographs or even disappear and do not have increased bone radiotracer uptake.
http://purl.obolibrary.org/obo/HP_0010740	Osteopathia striata	http://purl.obolibrary.org/obo/HP_0031367	Metaphyseal striations		A lamellar pattern visible on radiographs and mainly localized at the metaphyses of the long tubular bones. Pathologic-anatomical studies revealed that these benign signs on x-rays are the result of a juvenile metaphyseal bone necrosis. Calcifications in the necrotic marrow lead to this lamellar or lattice-like appearance.
http://purl.obolibrary.org/obo/HP_0010741	Pedal edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg.
http://purl.obolibrary.org/obo/HP_0010742	Edema of the upper limbs	http://purl.obolibrary.org/obo/HP_0000969	Edema		An abnormal accumulation of fluid beneath the skin of the arms.
http://purl.obolibrary.org/obo/HP_0010743	Short metatarsal	http://purl.obolibrary.org/obo/HP_0003026	Short long bone		Diminished length of a metatarsal bone, with resultant proximal displacement of the associated toe.
http://purl.obolibrary.org/obo/HP_0010744	Absent metatarsal bone	http://purl.obolibrary.org/obo/HP_0001964	Aplasia/Hypoplasia of metatarsal bones		A developmental abnormality characterized by the absence (aplasia) of a metatarsal bone.
http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010173	Aplasia/Hypoplasia of the phalanges of the toes		Absence of a digit or of one or more phalanges of a toe.
http://purl.obolibrary.org/obo/HP_0010747	Medial flaring of the eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		An abnormal distribution of eyebrow hair growth in the medial direction.
http://purl.obolibrary.org/obo/HP_0010748	Ectopic lacrimal punctum	http://purl.obolibrary.org/obo/HP_0011479	Abnormal lacrimal punctum morphology		Positioning of a lacrimal punctum other than at the medial margins of the eyelid.
http://purl.obolibrary.org/obo/HP_0010749	Blepharochalasis	http://purl.obolibrary.org/obo/HP_0100540	Palpebral edema		Blepharochalasis is characterized by recurrent, non-painful, nonerythematous episodes of eyelid edema. It has been divided into hypertrophic and atrophic forms. In the hypertrophic form recurrent edema results in orbital fat herniation through a weakened orbital septum. Most patients who have blepharochalasis present in an atrophic condition with atrophy of redundant eyelid skin and superior nasal fat pads.
http://purl.obolibrary.org/obo/HP_0010750	Dermatochalasis	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Loss of elasticity of the upper and lower eyelids causing the skin to sag and bulge.
http://purl.obolibrary.org/obo/HP_0010751	Dimple chin	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		A persistent midline depression of the skin over the fat pad of the chin.
http://purl.obolibrary.org/obo/HP_0010752	Cleft mandible	http://purl.obolibrary.org/obo/HP_0010753	Midline defect of mandible		Midline deficiency of the mandible and some or all overlying tissues.
http://purl.obolibrary.org/obo/HP_0010754	Abnormality of the temporomandibular joint	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		An anomaly of the temporomandibular joint.
http://purl.obolibrary.org/obo/HP_0010755	Asymmetry of the maxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		Asymmetry between the left and right sides of the maxilla.
http://purl.obolibrary.org/obo/HP_0010756	Aplasia/Hypoplasia of the premaxilla	http://purl.obolibrary.org/obo/HP_0010758	Abnormality of the premaxilla		Absence or underdevelopment of the premaxilla.
http://purl.obolibrary.org/obo/HP_0010757	Aplasia of the premaxilla	http://purl.obolibrary.org/obo/HP_0010756	Aplasia/Hypoplasia of the premaxilla		Absence of the premaxilla, which is the embryonic structure that forms the anterior part of the maxilla.
http://purl.obolibrary.org/obo/HP_0010758	Abnormality of the premaxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		An abnormality of the premaxilla, the most anterior part of the maxilla that usually bears the central and lateral incisors and includes the anterior nasal spine and inferior aspect of the piriform rim. The premaxilla contains the bone and teeth of the primary palate.
http://purl.obolibrary.org/obo/HP_0010759	Prominence of the premaxilla	http://purl.obolibrary.org/obo/HP_0010758	Abnormality of the premaxilla		Prominent positioning of the premaxilla in relation to the rest of the maxilla, the facial skeleton, or mandible. Not necessarily caused by an increase in size (hypertrophy of) the premaxilla.
http://purl.obolibrary.org/obo/HP_0010761	Broad columella	http://purl.obolibrary.org/obo/HP_0009929	Abnormal columella morphology		Increased width of the columella.
http://purl.obolibrary.org/obo/HP_0010763	Low insertion of columella	http://purl.obolibrary.org/obo/HP_0009929	Abnormal columella morphology		Insertion of the posterior columella below the nasal base.
http://purl.obolibrary.org/obo/HP_0010764	Short eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		Decreased length of the eyelashes (subjective).
http://purl.obolibrary.org/obo/HP_0010769	Pilonidal sinus	http://purl.obolibrary.org/obo/HP_0010767	Sacrococcygeal pilonidal abnormality		A sinus in the coccygeal region (the region of the intergluteal cleft). A pilonidal sinus often contains hair and skin debris.
http://purl.obolibrary.org/obo/HP_0010771	Pilonidal abscess	http://purl.obolibrary.org/obo/HP_0010767	Sacrococcygeal pilonidal abnormality		A hair-containing cyst or sinus usually in the coccygeal region.
http://purl.obolibrary.org/obo/HP_0010772	Anomalous pulmonary venous return	http://purl.obolibrary.org/obo/HP_0030968	Abnormal pulmonary vein morphology		A developmental defect characterized by abnormal connection of one or more pulmonary veins to the superior or inferior vena cava, the right atrium, or the coronary sinus, resulting in a left-to-right shunt of oxygenated blood.
http://purl.obolibrary.org/obo/HP_0010773	Partial anomalous pulmonary venous return	http://purl.obolibrary.org/obo/HP_0010772	Anomalous pulmonary venous return		A form of anomalous pulmonary venous return in which not all pulmonary veins drain abnormally. Partial anomalous pulmonary venous return frequently involves one or both of the veins from one lung.
http://purl.obolibrary.org/obo/HP_0010774	Cor triatriatum	http://purl.obolibrary.org/obo/HP_0005120	Abnormal cardiac atrium morphology		The presence of an additional membrane in the left or right cardiac atrium which results in the subdivision of the affected atrium (and thus in total three atria, whence the name).
http://purl.obolibrary.org/obo/HP_0010775	Vascular ring	http://purl.obolibrary.org/obo/HP_0011587	Abnormal branching pattern of the aortic arch		A developmental defect of the aortic arch system in which the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches. This occurs if the normal process of regression and persistence of the bilateral embryonic aortic arches fails.
http://purl.obolibrary.org/obo/HP_0010776	Tracheobronchmegaly	http://purl.obolibrary.org/obo/HP_0010778	Tracheomegaly		Marked widening of the trachea and major bronchi that may be predispose to chronic respiratory tract infection.
http://purl.obolibrary.org/obo/HP_0010777	Bronchomegaly	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Marked widening of the major bronchi that may be predispose to chronic respiratory tract infection.
http://purl.obolibrary.org/obo/HP_0010778	Tracheomegaly	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		Marked widening of the trachea.
http://purl.obolibrary.org/obo/HP_0010779	Large pelvis bone	http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology		The presence of an abnormally large pelvis.
http://purl.obolibrary.org/obo/HP_0010780	Hyperacusis	http://purl.obolibrary.org/obo/HP_5200060	Auditory hypersensitivity		Over-sensitivity to certain frequency ranges of sound.
http://purl.obolibrary.org/obo/HP_0010782	Shoulder dimple	http://purl.obolibrary.org/obo/HP_0010781	Skin dimple		A subtype of skin dimples occurring in the shoulder region.
http://purl.obolibrary.org/obo/HP_0010785	Gonadal neoplasm	http://purl.obolibrary.org/obo/HP_0010787	Genital neoplasm		A tumor (abnormal growth of tissue) of a gonad.
http://purl.obolibrary.org/obo/HP_0010786	Urinary tract neoplasm	http://purl.obolibrary.org/obo/HP_0007379	Neoplasm of the genitourinary tract		The presence of a neoplasm of the urinary system.
http://purl.obolibrary.org/obo/HP_0010787	Genital neoplasm	http://purl.obolibrary.org/obo/HP_0007379	Neoplasm of the genitourinary tract		A tumor (abnormal growth of tissue) of the genital system.
http://purl.obolibrary.org/obo/HP_0010790	Hypoplasia of the Leydig cells	http://purl.obolibrary.org/obo/HP_0010789	Abnormality of the Leydig cells		Underdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone.
http://purl.obolibrary.org/obo/HP_0010791	Hyperplasia of the Leydig cells	http://purl.obolibrary.org/obo/HP_0010789	Abnormality of the Leydig cells		Hypertrophy or overdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone.
http://purl.obolibrary.org/obo/HP_0010793	Bifid nail	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		A digit with two nails, with at least some soft tissue between them.
http://purl.obolibrary.org/obo/HP_0010794	Impaired visuospatial constructive cognition	http://purl.obolibrary.org/obo/HP_0001328	Specific learning disability		Reduced ability affecting mainly visuospatial cognition which may be tested using pattern construction (for example by Differential Ability Scales, which test a person's strengths and weaknesses across a range of intellectual abilities).
http://purl.obolibrary.org/obo/HP_0010795	Cerebellar glioma	http://purl.obolibrary.org/obo/HP_0009733	Glioma		A glioma affecting the cerebellum.
http://purl.obolibrary.org/obo/HP_0010796	Brainstem glioma	http://purl.obolibrary.org/obo/HP_0009733	Glioma		A glioma affecting the brainstem.
http://purl.obolibrary.org/obo/HP_0010797	Hemangioblastoma	http://purl.obolibrary.org/obo/HP_0100835	Benign neoplasm of the central nervous system		A hemangioblastoma is a benign vascular neoplasm that arises almost exclusively in the central nervous system. Hemangioblastomas consist of a tightly packed cluster of small blood vessels forming a mass of up to 1 or 2 cm in diameter.
http://purl.obolibrary.org/obo/HP_0010798	Lip freckle	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Increased focal pigmentation of the vermilion of the lips.
http://purl.obolibrary.org/obo/HP_0010799	Pinealoma	http://purl.obolibrary.org/obo/HP_0030693	Supratentorial neoplasm		A neoplasm of the pineal gland.
http://purl.obolibrary.org/obo/HP_0010800	Absent cupid's bow	http://purl.obolibrary.org/obo/HP_0011339	Abnormality of upper lip vermillion		Lack of paramedian peaks and median notch of the upper lip vermilion.
http://purl.obolibrary.org/obo/HP_0010801	Underdeveloped nasolabial fold	http://purl.obolibrary.org/obo/HP_0005289	Abnormal nasolabial region morphology		Reduced bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion or commissure).
http://purl.obolibrary.org/obo/HP_0010802	Perioral hyperpigmentation	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		Increased pigmentation, either focal or generalized, of the skin surrounding the vermilion of the lips.
http://purl.obolibrary.org/obo/HP_0010803	Everted upper lip vermilion	http://purl.obolibrary.org/obo/HP_0012472	Eclabion		Inner aspect of the upper lip vermilion (normally apposing the teeth) visible in a frontal view, i.e., the presence of an everted upper lip.
http://purl.obolibrary.org/obo/HP_0010804	Tented upper lip vermilion	http://purl.obolibrary.org/obo/HP_0011339	Abnormality of upper lip vermillion		Triangular appearance of the oral aperture with the apex in the midpoint of the upper vermilion and the lower vermilion forming the base.
http://purl.obolibrary.org/obo/HP_0010805	Upturned corners of mouth	http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape		Oral commissures positioned superior to the midline labial fissure.
http://purl.obolibrary.org/obo/HP_0010806	U-Shaped upper lip vermilion	http://purl.obolibrary.org/obo/HP_0011339	Abnormality of upper lip vermillion		Gentle upward curve of the upper lip vermilion such that the center is placed well superior to the commissures.
http://purl.obolibrary.org/obo/HP_0010807	Open bite	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Visible space between the dental arches in occlusion.
http://purl.obolibrary.org/obo/HP_0010808	Protruding tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Tongue extending beyond the alveolar ridges or teeth at rest.
http://purl.obolibrary.org/obo/HP_0010809	Broad uvula	http://purl.obolibrary.org/obo/HP_0000172	Abnormal uvula morphology		Increased width of the uvula (subjective finding).
http://purl.obolibrary.org/obo/HP_0010810	Long uvula	http://purl.obolibrary.org/obo/HP_0000172	Abnormal uvula morphology		Increased length of the uvula.
http://purl.obolibrary.org/obo/HP_0010811	Narrow uvula	http://purl.obolibrary.org/obo/HP_0000172	Abnormal uvula morphology		Decreased width of the uvula.
http://purl.obolibrary.org/obo/HP_0010812	Short uvula	http://purl.obolibrary.org/obo/HP_0010293	Aplasia/Hypoplasia of the uvula		Decreased length of the uvula.
http://purl.obolibrary.org/obo/HP_0010813	Abnormal number of hair whorls	http://purl.obolibrary.org/obo/HP_0010721	Abnormal hair whorl		More than two clockwise hair whorls.
http://purl.obolibrary.org/obo/HP_0010814	Abnormal position of hair whorl	http://purl.obolibrary.org/obo/HP_0010721	Abnormal hair whorl		Hair growth from a single point on the scalp in any location other than lateral to the midline and close to the vertex of the skull.
http://purl.obolibrary.org/obo/HP_0010815	Nevus sebaceous	http://purl.obolibrary.org/obo/HP_0010816	Epidermal nevus		A congenital, hairless plaque consisting of overgrown epidermis, sebaceous glands, hair follicles, apocrine glands and connective tissue. They are a variant of epidermal naevi. Sebaceous naevi most often appear on the scalp, but they may also arise on the face, neck or forehead. At birth, a sevaceous nevus typically appears as a solitary, smooth, yellow-orange hairless patch. Sebaceous naevi become more pronounced around adolescence, often appearing bumpy, warty or scaly.
http://purl.obolibrary.org/obo/HP_0010816	Epidermal nevus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		Epidermal naevi are due to an overgrowth of the epidermis and may be present at birth (50%) or develop during childhood.
http://purl.obolibrary.org/obo/HP_0010817	Linear nevus sebaceous	http://purl.obolibrary.org/obo/HP_0010815	Nevus sebaceous		A type of nevus sebaceous with a linear form, raised borders and yellowish color.
http://purl.obolibrary.org/obo/HP_0010818	Generalized tonic seizure	http://purl.obolibrary.org/obo/HP_0032792	Tonic seizure		A generalized tonic seizure is a type of generalized motor seizure characterized by bilateral limb stiffening or elevation, often with neck stiffening without a subsequent clonic phase. The tonic activity can be a sustained abnormal posture, either in extension or flexion, sometimes accompanied by tremor of the extremities.
http://purl.obolibrary.org/obo/HP_0010819	Atonic seizure	http://purl.obolibrary.org/obo/HP_0020219	Motor seizure		Atonic seizure is a type of motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1 to 2 seconds, involving head, trunk, jaw, or limb musculature.
http://purl.obolibrary.org/obo/HP_0010820	Focal emotional seizure with crying	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		Focal emotional seizure with crying (dacrystic) is characterized by the presence of stereotyped crying, this may be accompanied by lacrimation, sad facial expression and sobbing. The subjective emotion of sadness may or may not be present.
http://purl.obolibrary.org/obo/HP_0010821	Focal emotional seizure with laughing	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		Focal emotional seizure with laughing (gelastic) is characterized by bursts of laughter or giggling, usually without appropriate related emotion of happiness, and described as 'mirthless'.
http://purl.obolibrary.org/obo/HP_0010822	Scintillating scotoma	http://purl.obolibrary.org/obo/HP_0000575	Scotoma		A scintillating scotoma is a common visual aura that can precede a migraine, whereby a spot of flickering light near the center of the visual fields occurs. The spot prevents vision, and is thus termed scotoma. The scotoma can extend into one or more shimmering arcs of white or colored flashing lights.
http://purl.obolibrary.org/obo/HP_0010823	Ridged cranial sutures	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		An overlap of the bony plates of the skull in an infant, with or without early closure.
http://purl.obolibrary.org/obo/HP_0010824	Abnormal fifth cranial nerve morphology	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		Any structural abnormality of the fifth cranial nerve.
http://purl.obolibrary.org/obo/HP_0010825	Abnormality of the eleventh cranial nerve	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		Abnormality of the eleventh cranial nerve.
http://purl.obolibrary.org/obo/HP_0010826	Abnormality of the twelfth cranial nerve	http://purl.obolibrary.org/obo/HP_3000075	Abnormal lingual nerve morphology		Abnormality of the twelfth cranial nerve.
http://purl.obolibrary.org/obo/HP_0010827	Abnormal seventh cranial physiology	http://purl.obolibrary.org/obo/HP_0031910	Abnormal cranial nerve physiology		Abnormality of the seventh cranial nerve sometimes also referred to as the facial nerve.
http://purl.obolibrary.org/obo/HP_0010828	Hemifacial spasm	http://purl.obolibrary.org/obo/HP_0003739	Myoclonic spasms		Intermittent clonic or tonic contraction of muscles supplied by facial nerve. Muscles are relaxed in between contractions.
http://purl.obolibrary.org/obo/HP_0010829	Impaired temperature sensation	http://purl.obolibrary.org/obo/HP_0033748	Hypoesthesia		A reduced ability to discriminate between different temperatures.
http://purl.obolibrary.org/obo/HP_0010830	Impaired tactile sensation	http://purl.obolibrary.org/obo/HP_0033748	Hypoesthesia		A reduced sense of touch (tactile sensation). This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus.
http://purl.obolibrary.org/obo/HP_0010832	Abnormality of pain sensation	http://purl.obolibrary.org/obo/HP_0033747	Abnormal exteroceptive sensation		Pain is an unpleasant sensation that can range from mild, localized discomfort to agony, whereby the physical part of pain results from nerve stimulation and is often accompanied by an emotional component. This term groups abnormalities in pain sensation presumed to result from abnormalities related to the specific nerve fibers that carry the pain impulses to the brain.
http://purl.obolibrary.org/obo/HP_0010833	Spontaneous pain sensation	http://purl.obolibrary.org/obo/HP_0010832	Abnormality of pain sensation		Spontaneous pain is a kind of neuropathic pain which occurs without an identifiable trigger.
http://purl.obolibrary.org/obo/HP_0010835	Dissociated sensory loss	http://purl.obolibrary.org/obo/HP_0003474	Somatic sensory dysfunction		A pattern of sensory loss with selective loss of touch sensation and proprioception without loss of pain and temperature, or vice-versa.
http://purl.obolibrary.org/obo/HP_0010836	Abnormal circulating copper concentration	http://purl.obolibrary.org/obo/HP_0011030	Abnormal circulating transition element cation concentration		Any deviation from the normal concentration of copper cation in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010837	Decreased circulating ceruloplasmin concentration	http://purl.obolibrary.org/obo/HP_0033144	Abnormal circulating ceruloplasmin concentration		The concentration of ceruloplasmin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0010838	High nonceruloplasmin-bound serum copper	http://purl.obolibrary.org/obo/HP_0010836	Abnormal circulating copper concentration		An increased concentration of non ceruloplasmin bound copper in the blood.
http://purl.obolibrary.org/obo/HP_0010839	Increased urinary copper concentration	http://purl.obolibrary.org/obo/HP_0045036	Abnormal urinary copper concentration		An increased concentration of copper in the urine.
http://purl.obolibrary.org/obo/HP_0010841	Multifocal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		An abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG) and being identified at multiple locations (foci).
http://purl.obolibrary.org/obo/HP_0010843	EEG with focal slow activity	http://purl.obolibrary.org/obo/HP_0011203	EEG with abnormally slow frequencies		Focal (localized) slow activity reflects focal dysfunction, not diffuse dysfunction (i.e., encephalopathy).
http://purl.obolibrary.org/obo/HP_0010844	EEG with multifocal slow activity	http://purl.obolibrary.org/obo/HP_0011203	EEG with abnormally slow frequencies		Multifocal slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010845	EEG with generalized slow activity	http://purl.obolibrary.org/obo/HP_0011203	EEG with abnormally slow frequencies		Diffuse slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010847	EEG with spike-wave complexes (<2.5 Hz)	http://purl.obolibrary.org/obo/HP_0010850	EEG with spike-wave complexes		The presence of complexes of slow spikes and slow waves (<2.5 Hz) in electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010848	EEG with spike-wave complexes (2.5-3.5 Hz)	http://purl.obolibrary.org/obo/HP_0010850	EEG with spike-wave complexes		The presence of complexes of spikes and waves (2.5-3.5 Hz) in electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010849	EEG with spike-wave complexes (>3.5 Hz)	http://purl.obolibrary.org/obo/HP_0010850	EEG with spike-wave complexes		The presence of complexes of spikes and waves (>3.5 Hz) in electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010851	EEG with burst suppression	http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges		The burst suppression pattern in electroencephalography refers to a characteristic periodic pattern of low voltage (<10 microvolts) suppressed background and a relatively shorter pattern of higher amplitude slow, sharp, and spiking complexes.
http://purl.obolibrary.org/obo/HP_0010852	EEG with photoparoxysmal response	http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality		EEG abnormalities (epileptiform discharges) evoked by flashing lights or black and white striped patterns.
http://purl.obolibrary.org/obo/HP_0010853	EEG with periodic lateralized epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011186	Focal epileptiform discharges with limited propagation to contralateral hemisphere		Periodic lateralized epileptiform discharges (PLEDs)are periodic, lateralized, and epileptiform. PLEDs show a relatively constant interval between discharges (0.5 to 3 seconds).
http://purl.obolibrary.org/obo/HP_0010854	EEG with generalized low amplitude activity	http://purl.obolibrary.org/obo/HP_0011201	EEG with changes in voltage		An abnormal generalized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010855	EEG with localized low amplitude activity	http://purl.obolibrary.org/obo/HP_0011201	EEG with changes in voltage		An abnormal localized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010856	EEG with periodic complexes	http://purl.obolibrary.org/obo/HP_0010857	EEG with periodic abnormalities		Periodically occurring generalized periodic complexes.
http://purl.obolibrary.org/obo/HP_0010857	EEG with periodic abnormalities	http://purl.obolibrary.org/obo/HP_0011200	EEG with generalized polymorphic epileptiform discharges		Periodically recurring abnormalities in the EEG.
http://purl.obolibrary.org/obo/HP_0010858	EEG with hyperventilation-induced epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011182	Interictal epileptiform activity		Epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0010859	Frank breech presentation	http://purl.obolibrary.org/obo/HP_0001623	Breech presentation		A kind of breech presentation in which the hips are flexed and the knees are extended.
http://purl.obolibrary.org/obo/HP_0010860	Complete breech presentation	http://purl.obolibrary.org/obo/HP_0001623	Breech presentation		A kind of breech presentation in which the hips are flexed and the knees are flexed.
http://purl.obolibrary.org/obo/HP_0010861	Incomplete breech presentation	http://purl.obolibrary.org/obo/HP_0001623	Breech presentation		A kind of breech presentation in which one or both hips are extended and one or both of the fetus' feet are pointing down and entering the birth canal.
http://purl.obolibrary.org/obo/HP_0010862	Delayed fine motor development	http://purl.obolibrary.org/obo/HP_0001270	Motor delay		A type of motor delay characterized by a delay in acquiring the ability to control the fingers and hands.
http://purl.obolibrary.org/obo/HP_0010863	Receptive language delay	http://purl.obolibrary.org/obo/HP_0000750	Delayed speech and language development		A delay in the acquisition of the ability to understand the speech of others.
http://purl.obolibrary.org/obo/HP_0010865	Oppositional defiant disorder	http://purl.obolibrary.org/obo/HP_0000718	Aggressive behavior		An enduring pattern of uncooperative, defiant, and hostile behavior towards authority figures that does not involve major antisocial violations, is not accounted for by the child's developmental stage, and results in significant functional impairment. A certain level of oppositional behavior is common in children and adolescents.
http://purl.obolibrary.org/obo/HP_0010867	Dyssynergia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts.
http://purl.obolibrary.org/obo/HP_0010868	Ocular dyssynergia	http://purl.obolibrary.org/obo/HP_0010867	Dyssynergia		A type of dyssynergia affecting eye movements and characterized by the inability to smoothly follow a visual target across the visual field.
http://purl.obolibrary.org/obo/HP_0010869	Asynergia	http://purl.obolibrary.org/obo/HP_0010867	Dyssynergia		A type of dyssynergy characterized by the lack of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed.
http://purl.obolibrary.org/obo/HP_0010871	Sensory ataxia	http://purl.obolibrary.org/obo/HP_0010831	Impaired proprioception		Incoordination of movement caused by a deficit in the sensory nervous system. Sensory ataxia can be distinguished from cerebellar ataxia by asking the patient to close his or her eyes. Persons with cerebellar ataxia show only a minimal worsening of symptoms, whereas persons with sensory ataxia show a marked worsening of symptoms.
http://purl.obolibrary.org/obo/HP_0010873	Cervical spinal cord atrophy	http://purl.obolibrary.org/obo/HP_0006827	Atrophy of the spinal cord		Atrophy of the cervical segment of the spinal cord.
http://purl.obolibrary.org/obo/HP_0010874	Tendon xanthomatosis	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		The presence of xanthomas (intra-and extra-cellular accumulations of cholesterol) extensor tendons (typically over knuckles, Achilles tendon, knee, and elbows).
http://purl.obolibrary.org/obo/HP_0010875	Chaddock reflex	http://purl.obolibrary.org/obo/HP_0007256	Abnormal pyramidal sign		A diagnostic reflex elicited by stimulation of the skin over the surface of the lateral malleolus of the foot. The Chaddock refelx is present if there is extension of one or more or all of the toes with or without fanning of them when the external inframalleolar skin is stimulated. The Chaddock sign, similar to the Babinski sign, is taken to be an indication of disease of the spinocortical (pyramidal) tract.
http://purl.obolibrary.org/obo/HP_0010877	Monocular strabismus	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		A type of strabismus in which the fixating eye is always the same one, while the other eye is constantly deviated. Monocular strabismus is to be distinguished from alternating strabismus, in which either of the eyes 'squints' at different times.
http://purl.obolibrary.org/obo/HP_0010878	Fetal cystic hygroma	http://purl.obolibrary.org/obo/HP_0025667	Fetal neck anomaly		The presence during the prenatal period of a cystic mass with multiple septa with multiple, asymmetric, thin-walled cysts near the posterior aspect of the neck. Fetal cystic hygroma can be defined as nuchal translucency with or without septations measuring greater than 3.0 mm. Increased NT refers to a measurement above the 95th centile, and the term is used irrespective of whether the collection of fluid is septated or not, and whether it is confined to the neck or envelopes the whole fetus. After 14 weeks, increased NT usually resolves, but in some cases it evolves into nuchal edema or cystic hygromas.
http://purl.obolibrary.org/obo/HP_0010880	Increased nuchal translucency	http://purl.obolibrary.org/obo/HP_0025667	Fetal neck anomaly		Nuchal translucency is the sonographic appearance of subcutaneous accumulation of liquid in the back of the fetal neck in the first trimester of pregnancy (11-14 gestational weeks of pregnancy).
http://purl.obolibrary.org/obo/HP_0010882	Pulmonary valve atresia	http://purl.obolibrary.org/obo/HP_0001641	Abnormal pulmonary valve morphology		A congenital disorder of the pulmonary valve in which the orifice of the valve fails to develop.
http://purl.obolibrary.org/obo/HP_0010883	Aortic valve atresia	http://purl.obolibrary.org/obo/HP_0001646	Abnormal aortic valve morphology		A congenital disorder of the aortic valve in which the orifice of the valve fails to develop.
http://purl.obolibrary.org/obo/HP_0010886	Osteochondritis dissecans	http://purl.obolibrary.org/obo/HP_0040188	Osteochondrosis		A joint disorder caused by blood deprivation in the subchondral bone causing the subchondral bone to die in a process called avascular necrosis. The bone is then reabsorbed by the body, leaving the articular cartilage it supported prone to damage. The result is fragmentation (dissection) of both cartilage and bone, and the free movement of these osteochondral fragments within the joint space, causing pain and further damage.
http://purl.obolibrary.org/obo/HP_0010888	Morbus Koehler	http://purl.obolibrary.org/obo/HP_0100339	Abnormality of the os naviculare pedis		Morbus Koehler is a Juvenile aseptic necrosis affecting the Os naviculare pedis.
http://purl.obolibrary.org/obo/HP_0010889	Morbus Kienboeck	http://purl.obolibrary.org/obo/HP_0100323	Juvenile aseptic necrosis		Morbus Kienboeck is a Juvenile aseptic necrosis affecting the Os lunatum.
http://purl.obolibrary.org/obo/HP_0010890	Morbus Osgood-Schlatter	http://purl.obolibrary.org/obo/HP_0100323	Juvenile aseptic necrosis		Morbus Osgood-Schlatter is a Juvenile aseptic necrosis affecting the Tuberositas tibiae.
http://purl.obolibrary.org/obo/HP_0010891	Morbus Scheuermann	http://purl.obolibrary.org/obo/HP_0100323	Juvenile aseptic necrosis		A developmental growth retardation of the vertebral end plates that may lead to secondary destruction of the vertebral end plates and protrusion of the nucleus pulposus into the vertebral body (so called Schmorl's nodes as seen on x-rays).
http://purl.obolibrary.org/obo/HP_0010892	Abnormal circulating branched chain amino acid concentration	http://purl.obolibrary.org/obo/HP_0033107	Abnormal circulating proteinogenic amino acid concentration		Any deviation from the normal concentration of a branched chain family amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010894	Abnormal circulating serine family amino acid concentration	http://purl.obolibrary.org/obo/HP_0033107	Abnormal circulating proteinogenic amino acid concentration		Any deviation from the normal concentration of serine family amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010896	Hypersarcosinemia	http://purl.obolibrary.org/obo/HP_0010898	Abnormal circulating sarcosine concentration		An elevated plasma concentration of sarcosine.
http://purl.obolibrary.org/obo/HP_0010897	Hypersarcosinuria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An elevated urinary concentration of sarcosine.
http://purl.obolibrary.org/obo/HP_0010898	Abnormal circulating sarcosine concentration	http://purl.obolibrary.org/obo/HP_0010894	Abnormal circulating serine family amino acid concentration		An deviation from the normal concentration of sarcosine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010899	Abnormal circulating aspartate family amino acid concentration	http://purl.obolibrary.org/obo/HP_0033107	Abnormal circulating proteinogenic amino acid concentration		Any deviation from the normal concentration of an aspartate family amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010902	Abnormal circulating glutamine family amino acid concentration	http://purl.obolibrary.org/obo/HP_0033107	Abnormal circulating proteinogenic amino acid concentration		Any deviation from the normal concentration of glutamine family amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010904	Abnormal circulating histidine concentration	http://purl.obolibrary.org/obo/HP_0004338	Abnormal circulating aromatic amino acid concentration		Any deviation from the normal concentration of histidine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010906	Hyperhistidinemia	http://purl.obolibrary.org/obo/HP_0010904	Abnormal circulating histidine concentration		The concentration of histidine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0010910	Hypervalinemia	http://purl.obolibrary.org/obo/HP_0010914	Abnormal circulating valine concentration		The concentration of valine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0010911	Hyperleucinemia	http://purl.obolibrary.org/obo/HP_0004357	Abnormal circulating leucine concentration		The concentration of leucine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0010912	Abnormal circulating isoleucine concentration	http://purl.obolibrary.org/obo/HP_0010892	Abnormal circulating branched chain amino acid concentration		Any deviation from the normal concentration of isoleucine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010913	Hyperisoleucinemia	http://purl.obolibrary.org/obo/HP_0010912	Abnormal circulating isoleucine concentration		The concentration of isoleucine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0010914	Abnormal circulating valine concentration	http://purl.obolibrary.org/obo/HP_0010892	Abnormal circulating branched chain amino acid concentration		Any deviation from the normal concentration of valine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010915	Abnormal circulating pyruvate family amino acid concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		Any deviation from the normal concentration of pyruvate family amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		Zonular cataracts are defined to be cataracts that affect specific regions of the lens.
http://purl.obolibrary.org/obo/HP_0010921	Coralliform cataract	http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract		A 'coral-like' pattern of opacity in the lens of the eye. That is, a cataract with an irregular, stellate form.
http://purl.obolibrary.org/obo/HP_0010922	Membranous cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A form of cataract in which the lens substance has shrunk, leaving a collapsed, flattened capsule with little or no cortex or epithelium on the lens.
http://purl.obolibrary.org/obo/HP_0010923	Anterior subcapsular cataract	http://purl.obolibrary.org/obo/HP_0000523	Subcapsular cataract		A type of cataract affecting the anterior pole of lens immediately adjacent to ('beneath') the lens capsule.
http://purl.obolibrary.org/obo/HP_0010924	Posterior cortical cataract	http://purl.obolibrary.org/obo/HP_0100019	Cortical cataract		A cataract that affects the posterior part of the cortex of the lens.
http://purl.obolibrary.org/obo/HP_0010926	Aculeiform cataract	http://purl.obolibrary.org/obo/HP_0100018	Nuclear cataract		A kind of nuclear cataract characterized by fiberglasslike or needlelike crystals projecting in different directions, through or close to the axial region of the lens.
http://purl.obolibrary.org/obo/HP_0010927	Abnormal circulating inorganic divalent cation concentration	http://purl.obolibrary.org/obo/HP_0010929	Abnormal circulating inorganic cation concentration		An abnormality of divalent inorganic cation homeostasis.
http://purl.obolibrary.org/obo/HP_0010929	Abnormal circulating inorganic cation concentration	http://purl.obolibrary.org/obo/HP_0003111	Abnormal circulating electrolyte concentration		Any deviation from the normal concentration of inorganic cation in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010930	Abnormal circulating monovalent inorganic cation concentration	http://purl.obolibrary.org/obo/HP_0010929	Abnormal circulating inorganic cation concentration		Any deviation from the normal concentration of monovalent inorganic cation in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010934	Xanthinuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An increased concentration of xanthine in the urine.
http://purl.obolibrary.org/obo/HP_0010937	Abnormal nasal skeleton morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		An abnormality of the nasal skeleton.
http://purl.obolibrary.org/obo/HP_0010939	Abnormal nasal bone morphology	http://purl.obolibrary.org/obo/HP_0010937	Abnormal nasal skeleton morphology		An abnormality of the nasal bone, comprising the left nasal bone and the right nasal bone.
http://purl.obolibrary.org/obo/HP_0010940	Aplasia/Hypoplasia of the nasal bone	http://purl.obolibrary.org/obo/HP_0010939	Abnormal nasal bone morphology		Absence or underdevelopment of the nasal bone.
http://purl.obolibrary.org/obo/HP_0010941	Aplasia of the nasal bone	http://purl.obolibrary.org/obo/HP_0010940	Aplasia/Hypoplasia of the nasal bone		Absence of the nasal bone.
http://purl.obolibrary.org/obo/HP_0010942	Echogenic intracardiac focus	http://purl.obolibrary.org/obo/HP_0011425	Fetal ultrasound soft marker		A finding of a focus of increased echogenicity upon prenatal ultrasound examination of the fetus. The foci may be present in one or both ventricles. Echogenic intracardiac focus (EICF) is defined as a focus of echogenicity comparable to bone, in the region of the papillary muscle in either or both ventricles of the fetal heart.
http://purl.obolibrary.org/obo/HP_0010943	Echogenic fetal bowel	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Echogenic bowel is defined as fetal bowel with homogenous areas of echogenicity that are equal to or greater than that of surrounding bone.
http://purl.obolibrary.org/obo/HP_0010944	Abnormal renal pelvis morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An abnormality of the renal pelvis.
http://purl.obolibrary.org/obo/HP_0010945	Fetal pyelectasis	http://purl.obolibrary.org/obo/HP_0010944	Abnormal renal pelvis morphology		Mild pyelectasis is defined as a hypoechoic spherical or elliptical space within the renal pelvis that measures at least 5mm and not more than 10 mm. The measurement is taken on a transverse section through the fetal renal pelvis using the maximum anterior-to-posterior measurement.
http://purl.obolibrary.org/obo/HP_0010947	Abnormality of ductus venosus blood flow	http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology		A first-trimester prenatal ultrasound finding of abnormal blood flow in the ductus venosus.
http://purl.obolibrary.org/obo/HP_0010949	Abnormality of umbilical vein blood flow	http://purl.obolibrary.org/obo/HP_0025657	Abnormal umbilical blood flow measurement		A first-trimester prenatal ultrasound finding of abnormal blood flow in the umbilical vein.
http://purl.obolibrary.org/obo/HP_0010951	Abnormal third ventricle morphology	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		An abnormality of the third ventricle.
http://purl.obolibrary.org/obo/HP_0010952	Mild fetal ventriculomegaly	http://purl.obolibrary.org/obo/HP_0034206	Abnormal fetal central nervous system morphology		A kind of ventriculomegaly occurring in the fetal period and usually diagnosed by prenatal ultrasound. Cerebral ventriculomegaly is defined by atrial measurements 10 mm or more. Mild ventriculomegaly (MVM) is defined as measurements between 10 and 15 mm. Measurements are obtained from an axial plane at the level of the thalamic nuclei just below the standard image to measure the BPD (PMID:16100637).
http://purl.obolibrary.org/obo/HP_0010953	Noncommunicating hydrocephalus	http://purl.obolibrary.org/obo/HP_0000238	Hydrocephalus		A form of hydrocephalus in which the flow of cerebrospinal fluid (CSF) within the cerebral ventricular system or in the outlets of the CSF to the arachnoid space is obstructed.
http://purl.obolibrary.org/obo/HP_0010954	Hypoplastic right ventricle	http://purl.obolibrary.org/obo/HP_0011723	Congenital malformation of the right heart		Underdevelopment of the right ventricle.
http://purl.obolibrary.org/obo/HP_0010956	Fetal megacystis	http://purl.obolibrary.org/obo/HP_0010955	Dilatation of the bladder		Fetal megacystis is an abnormally enlarged bladder identified at any gestational age.
http://purl.obolibrary.org/obo/HP_0010957	Congenital posterior urethral valve	http://purl.obolibrary.org/obo/HP_0034378	Urethrovesical occlusion		A developmental defect resulting in an obstructing membrane in the posterior male urethra.
http://purl.obolibrary.org/obo/HP_0010958	Bilateral renal agenesis	http://purl.obolibrary.org/obo/HP_0000104	Renal agenesis		A bilateral form of agenesis of the kidney.
http://purl.obolibrary.org/obo/HP_0010959	Congenital pulmonary airway malformation	http://purl.obolibrary.org/obo/HP_0005948	Multiple pulmonary cysts		Congenital pulmonary airway malformation (CPAM) - previously known as congenital cystic adenomatoid malformation (CCAM) - is a relatively rare developmental malformation of the lower respiratory tract. It is a hamartomatous, dysplastic developmental abnormality of the lung characterized by abnormal airway patterning during lung branching morphogenesis and is formed by abnormal branching of the immature bronchioles.
http://purl.obolibrary.org/obo/HP_0010963	Absence of stomach bubble on fetal sonography	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		By the 14th week of gestation it is nearly always possible to visualized the fluid-filled fetal stomach bubble on prenatal sonography. This term refers to the absence of a normal fetal stomach bubble on fetal ultrasonography performed at around 16 to 20 weeks' gestation.
http://purl.obolibrary.org/obo/HP_0010965	Abnormal circulating phytanic acid concentration	http://purl.obolibrary.org/obo/HP_0010964	Abnormal circulating long-chain fatty-acid concentration		Any deviation from the normal concentration of phytanic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010966	Abnormal circulating fatty acid anion concentration	http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration		Any deviation from the normal concentration of fatty acid anion in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010968	Abnormality of liposaccharide metabolism	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		An abnormality of liposaccharide metabolism.
http://purl.obolibrary.org/obo/HP_0010969	Abnormality of glycolipid metabolism	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		An abnormality of glycolipid metabolism.
http://purl.obolibrary.org/obo/HP_0010970	Blood group antigen abnormality	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		An abnormality of an erythrocyte cell surface molecule.
http://purl.obolibrary.org/obo/HP_0010971	Absence of Lutheran antigen on erythrocytes	http://purl.obolibrary.org/obo/HP_0010970	Blood group antigen abnormality		Absence of the Lutheran antigen (a type I integral membrane glycoprotein) from the surface of red blood cells.
http://purl.obolibrary.org/obo/HP_0010975	Abnormal total B cell count	http://purl.obolibrary.org/obo/HP_0002846	Abnormal B cell morphology		The absolute number of B cells in the blood, per microlitre is outside the limits of normal of the reference range for the appropriate sex and age-group.
http://purl.obolibrary.org/obo/HP_0010976	Decreased total B cell count	http://purl.obolibrary.org/obo/HP_0010975	Abnormal total B cell count		The absolute number of B cells in the blood, per microlitre is below the lower limit of normal of the reference range for the appropriate sex and age-group.
http://purl.obolibrary.org/obo/HP_0010979	Abnormal circulating lipoprotein cholesterol concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		Any deviation from the normal concentration of lipoprotein cholesterol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0010982	Polygenic inheritance	http://purl.obolibrary.org/obo/HP_0001426	Non-Mendelian inheritance		A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
http://purl.obolibrary.org/obo/HP_0010983	Oligogenic inheritance	http://purl.obolibrary.org/obo/HP_0001426	Non-Mendelian inheritance		A type of multifactorial inheritance governed by the simultaneous action of a few gene loci. It is recommended this term be used for traits governed by three loci, although it is noted that usage of this term in the literature is not uniform.
http://purl.obolibrary.org/obo/HP_0010984	Digenic inheritance	http://purl.obolibrary.org/obo/HP_0001426	Non-Mendelian inheritance		A type of multifactorial inheritance governed by the simultaneous action of two gene loci.
http://purl.obolibrary.org/obo/HP_0010988	Abnormality of the extrinsic pathway	http://purl.obolibrary.org/obo/HP_0003256	Abnormality of the coagulation cascade		An abnormality of the extrinsic pathway (also known as the tissue factor pathway) of the coagulation cascade.
http://purl.obolibrary.org/obo/HP_0010992	Stress urinary incontinence	http://purl.obolibrary.org/obo/HP_0000020	Urinary incontinence		Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing.
http://purl.obolibrary.org/obo/HP_0010997	Chromosomal breakage induced by ionizing radiation	http://purl.obolibrary.org/obo/HP_0040012	Chromosome breakage		Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with ionizing radiation.
http://purl.obolibrary.org/obo/HP_0010998	Increased susceptibility to spontaneous sister chromatid exchange	http://purl.obolibrary.org/obo/HP_0003220	Abnormality of chromosome stability		An increase in the number of spontaneous sister chromatid exchanges observed in cell culture of lymphocytes or other cells.
http://purl.obolibrary.org/obo/HP_0011003	High myopia	http://purl.obolibrary.org/obo/HP_0000545	Myopia		A severe form of myopia with greater than -6.00 diopters.
http://purl.obolibrary.org/obo/HP_0011005	Mixed cirrhosis	http://purl.obolibrary.org/obo/HP_0001394	Cirrhosis		A type of cirrhosis characterized by the presence of regenerative nodules of a variety of sizes.
http://purl.obolibrary.org/obo/HP_0011009	Acute	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Sudden appearance of disease manifestations over a short period of time.
http://purl.obolibrary.org/obo/HP_0011010	Chronic	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Slow, creeping onset, slow progress and long continuance of disease manifestations.
http://purl.obolibrary.org/obo/HP_0011011	Subacute	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Somewhat rapid onset and change of disease manifestations.
http://purl.obolibrary.org/obo/HP_0011012	Abnormal circulating polysaccharide concentration	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		A deviation from the normal concentration of a polysaccharide in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011022	Abnormal circulating unsaturated fatty acid concentration	http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration		Any deviation from the normal concentration of unsaturated fatty acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011024	Abnormality of the gastrointestinal tract	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		An abnormality of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology	http://purl.obolibrary.org/obo/HP_0000008	Abnormal morphology of female internal genitalia		An abnormality of the fallopian tube.
http://purl.obolibrary.org/obo/HP_0011028	Abnormality of blood circulation	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		An abnormality of blood circulation.
http://purl.obolibrary.org/obo/HP_0011030	Abnormal circulating transition element cation concentration	http://purl.obolibrary.org/obo/HP_0010929	Abnormal circulating inorganic cation concentration		Any deviation from the normal concentration of transition element cation in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011033	Impairment of fructose metabolism	http://purl.obolibrary.org/obo/HP_0032245	Abnormal metabolism		An impairment of a fructose metabolic process.
http://purl.obolibrary.org/obo/HP_0011036	Abnormality of renal excretion	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		An altered ability of the kidneys to void urine and/or specific substances.
http://purl.obolibrary.org/obo/HP_0011037	Decreased urine output	http://purl.obolibrary.org/obo/HP_0012590	Abnormal urine output		A decreased rate of urine production.
http://purl.obolibrary.org/obo/HP_0011041	Aplasia/Hypoplasia of the cervical spine	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		Aplasia or developmental hypoplasia of the cervical vertebral column.
http://purl.obolibrary.org/obo/HP_0011044	Abnormal number of permanent teeth	http://purl.obolibrary.org/obo/HP_0006483	Abnormal number of teeth		The presence of an altered number of of permanent teeth.
http://purl.obolibrary.org/obo/HP_0011045	Agenesis of permanent maxillary central incisor	http://purl.obolibrary.org/obo/HP_0006293	Agenesis of maxillary central incisor		Agenesis of upper secondary incisor.
http://purl.obolibrary.org/obo/HP_0011046	Agenesis of primary maxillary central incisor	http://purl.obolibrary.org/obo/HP_0006293	Agenesis of maxillary central incisor		Agenesis of upper central primary incisor.
http://purl.obolibrary.org/obo/HP_0011047	Agenesis of primary mandibular central incisor	http://purl.obolibrary.org/obo/HP_0006355	Agenesis of mandibular central incisor		Agenesis of lower primary incisor.
http://purl.obolibrary.org/obo/HP_0011048	Agenesis of permanent mandibular central incisor	http://purl.obolibrary.org/obo/HP_0006355	Agenesis of mandibular central incisor		Agenesis of lower secondary incisor.
http://purl.obolibrary.org/obo/HP_0011049	Agenesis of primary maxillary lateral incisor	http://purl.obolibrary.org/obo/HP_0000690	Agenesis of maxillary lateral incisor		Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor.
http://purl.obolibrary.org/obo/HP_0011050	Agenesis of permanent maxillary lateral incisor	http://purl.obolibrary.org/obo/HP_0000690	Agenesis of maxillary lateral incisor		Agenesis of one or more upper lateral secondary incisor.
http://purl.obolibrary.org/obo/HP_0011051	Agenesis of premolar	http://purl.obolibrary.org/obo/HP_0011076	Abnormality of premolar		Agenesis of premolar tooth.
http://purl.obolibrary.org/obo/HP_0011052	Agenesis of maxillary premolar	http://purl.obolibrary.org/obo/HP_0011051	Agenesis of premolar		Agenesis of maxillary premolar.
http://purl.obolibrary.org/obo/HP_0011053	Agenesis of mandibular premolar	http://purl.obolibrary.org/obo/HP_0011051	Agenesis of premolar		Agenesis of mandibular premolar.
http://purl.obolibrary.org/obo/HP_0011054	Agenesis of molar	http://purl.obolibrary.org/obo/HP_0011077	Abnormality of molar		Agenesis of molar tooth.
http://purl.obolibrary.org/obo/HP_0011055	Agenesis of permanent molar	http://purl.obolibrary.org/obo/HP_0011054	Agenesis of molar		Agenesis of secondary molar tooth.
http://purl.obolibrary.org/obo/HP_0011056	Agenesis of first permanent molar tooth	http://purl.obolibrary.org/obo/HP_0011055	Agenesis of permanent molar		Agenesis of either maxillary first permanent molar or mandibular first permanent molar or both.
http://purl.obolibrary.org/obo/HP_0011057	Agenesis of second permanent molar	http://purl.obolibrary.org/obo/HP_0011055	Agenesis of permanent molar		Agenesis of either mandibular second permanent molar or maxillary second permanent molar.
http://purl.obolibrary.org/obo/HP_0011058	Generalized periodontitis	http://purl.obolibrary.org/obo/HP_0020341	Unusual periodontitis		A generalized form of periodontitis.
http://purl.obolibrary.org/obo/HP_0011059	Localized periodontitis	http://purl.obolibrary.org/obo/HP_0020341	Unusual periodontitis		A localized form of periodontitis.
http://purl.obolibrary.org/obo/HP_0011060	Dentinogenesis imperfecta limited to primary teeth	http://purl.obolibrary.org/obo/HP_0000703	Dentinogenesis imperfecta		Developmental dysplasia of dentin affecting only the primary dentition.
http://purl.obolibrary.org/obo/HP_0011062	Misalignment of incisors	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Misaligned incisor.
http://purl.obolibrary.org/obo/HP_0011064	Abnormal number of incisors	http://purl.obolibrary.org/obo/HP_0006483	Abnormal number of teeth		The presence of an altered number of the incisor teeth.
http://purl.obolibrary.org/obo/HP_0011065	Conical incisor	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		An abnormal conical morphology of the incisor tooth.
http://purl.obolibrary.org/obo/HP_0011067	Mesiodens	http://purl.obolibrary.org/obo/HP_0011069	Supernumerary tooth		A supernumerary tooth in the midline between the maxillary central incisors.
http://purl.obolibrary.org/obo/HP_0011068	Odontoma	http://purl.obolibrary.org/obo/HP_0100612	Odontogenic neoplasm		The presence of an odontoma.
http://purl.obolibrary.org/obo/HP_0011069	Supernumerary tooth	http://purl.obolibrary.org/obo/HP_0006483	Abnormal number of teeth		The presence of one or more teeth additional to the normal number.
http://purl.obolibrary.org/obo/HP_0011070	Abnormal molar morphology	http://purl.obolibrary.org/obo/HP_0011077	Abnormality of molar		An abnormality of morphology of molar tooth.
http://purl.obolibrary.org/obo/HP_0011074	Localized hypoplasia of dental enamel	http://purl.obolibrary.org/obo/HP_0006297	Enamel hypoplasia		A localized form of developmental hypoplasia of the dental enamel.
http://purl.obolibrary.org/obo/HP_0011075	Green teeth	http://purl.obolibrary.org/obo/HP_0011073	Abnormality of dental color		A green staining of teeth.
http://purl.obolibrary.org/obo/HP_0011076	Abnormality of premolar	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		An abnormality of premolar tooth.
http://purl.obolibrary.org/obo/HP_0011077	Abnormality of molar	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		An abnormality of molar tooth.
http://purl.obolibrary.org/obo/HP_0011078	Abnormality of canine	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		An abnormality of canine tooth.
http://purl.obolibrary.org/obo/HP_0011080	Abnormal premolar morphology	http://purl.obolibrary.org/obo/HP_0011076	Abnormality of premolar		An abnormality of morphology of premolar tooth.
http://purl.obolibrary.org/obo/HP_0011082	Conical primary incisor	http://purl.obolibrary.org/obo/HP_0011065	Conical incisor		An abnormal conical morphology of the primary incisor.
http://purl.obolibrary.org/obo/HP_0011083	Conical maxillary incisor	http://purl.obolibrary.org/obo/HP_0011065	Conical incisor		An abnormal conical morphology of either maxillary primary incisor tooth or maxillary permanent incisor tooth or both.
http://purl.obolibrary.org/obo/HP_0011084	Hypocalcification of dental enamel	http://purl.obolibrary.org/obo/HP_0006285	Enamel hypomineralization		A form of hypomineralization of enamel characterized by reduced calcification.
http://purl.obolibrary.org/obo/HP_0011085	Hypomature dental enamel	http://purl.obolibrary.org/obo/HP_0006285	Enamel hypomineralization		A form of hypomineralization of enamel characterized by a chalky appearance of the enamel with orange, brown, or white color.
http://purl.obolibrary.org/obo/HP_0011086	Dentinogenesis imperfecta of primary and permanent teeth	http://purl.obolibrary.org/obo/HP_0000703	Dentinogenesis imperfecta		Developmental dysplasia of dentin or both the primary dentition and the permanent dentition.
http://purl.obolibrary.org/obo/HP_0011087	Talon cusp	http://purl.obolibrary.org/obo/HP_0033777	Supernumerary cusp		Talon cusp is an accessory cusp located near the cingulum (the portion of the lingual or palatal aspect of the tooth that forms a convex protuberance at the cervical third of the anatomic crown).
http://purl.obolibrary.org/obo/HP_0011088	Dens in dente	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		An abnormality of the incisor characterized by invagination of the enamel, giving a radiographic appearance that suggests a tooth within a tooth.
http://purl.obolibrary.org/obo/HP_0011089	Double tooth	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		Fusion of two adjacent teeth.
http://purl.obolibrary.org/obo/HP_0011090	Fused teeth	http://purl.obolibrary.org/obo/HP_0011089	Double tooth		The union of two separately developing tooth germs typically leading to one less tooth than normal in the affected dental arch.
http://purl.obolibrary.org/obo/HP_0011091	Gemination	http://purl.obolibrary.org/obo/HP_0011089	Double tooth		The development of two teeth from a single tooth bud, leading to a larger fused tooth.
http://purl.obolibrary.org/obo/HP_0011092	Mulberry molar	http://purl.obolibrary.org/obo/HP_0033777	Supernumerary cusp		Mulberry molars are irregular teeth generally affecting the first molars and are characterized by a grossly deformed crown imitating, as the name implies, the surface of a mulberry.
http://purl.obolibrary.org/obo/HP_0011093	Molarization of premolar	http://purl.obolibrary.org/obo/HP_0011080	Abnormal premolar morphology		Increased size and molar morphology of premolar tooth.
http://purl.obolibrary.org/obo/HP_0011094	Increased overbite	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		Maxillary teeth cover the mandibular teeth when biting to an increased degree. The feature is defined as a vertical overlap of the maxillary incisors over the mandibular incisors that exceeds 2 mm.
http://purl.obolibrary.org/obo/HP_0011095	Overjet	http://purl.obolibrary.org/obo/HP_0000692	Tooth malposition		An abnormal anteroposterior extension of the maxillary teeth beyond the plane of the mandibular teeth upon jaw closure.
http://purl.obolibrary.org/obo/HP_0011097	Epileptic spasm	http://purl.obolibrary.org/obo/HP_0020219	Motor seizure		A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: Grimacing, head nodding, or subtle eye movements. Epileptic spasms frequently occur in clusters. Infantile spasms are the best known form, but spasms can occur at all ages
http://purl.obolibrary.org/obo/HP_0011098	Speech apraxia	http://purl.obolibrary.org/obo/HP_0002186	Apraxia		A type of apraxia that is characterized by difficulty or inability to execute speech movements because of problems with coordination and motor problems, leading to incorrect articulation. An increase of errors with increasing word and phrase length may occur.
http://purl.obolibrary.org/obo/HP_0011099	Spastic hemiparesis	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Unilateral paresis (weakness) with spasticity of the affected muscles and increased tendon reflexes.
http://purl.obolibrary.org/obo/HP_0011102	Ileal atresia	http://purl.obolibrary.org/obo/HP_0011100	Intestinal atresia		An abnormal closure, or atresia of the tubular structure of the ileum.
http://purl.obolibrary.org/obo/HP_0011104	Abnormality of blood volume homeostasis	http://purl.obolibrary.org/obo/HP_0011028	Abnormality of blood circulation		An abnormality in the amount of volume occupied by intravascular blood.
http://purl.obolibrary.org/obo/HP_0011105	Hypervolemia	http://purl.obolibrary.org/obo/HP_0011104	Abnormality of blood volume homeostasis		An increase in the amount of intravascular fluid, particularly in the volume of the circulating blood.
http://purl.obolibrary.org/obo/HP_0011106	Hypovolemia	http://purl.obolibrary.org/obo/HP_0011104	Abnormality of blood volume homeostasis		An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood.
http://purl.obolibrary.org/obo/HP_0011107	Recurrent aphthous stomatitis	http://purl.obolibrary.org/obo/HP_5210251	Recurrent stomatitis		Recurrent episodes of ulceration of the oral mucosa, typically presenting as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border.
http://purl.obolibrary.org/obo/HP_0011108	Recurrent sinusitis	http://purl.obolibrary.org/obo/HP_0002788	Recurrent upper respiratory tract infections		A recurrent form of sinusitis.
http://purl.obolibrary.org/obo/HP_0011109	Chronic sinusitis	http://purl.obolibrary.org/obo/HP_0000246	Sinusitis		A chronic form of sinusitis.
http://purl.obolibrary.org/obo/HP_0011111	Abnormal immune serum protein physiology	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		An abnormality of the concentration or function of circulating immune proteins.
http://purl.obolibrary.org/obo/HP_0011112	Abnormal circulating cytokine concentration	http://purl.obolibrary.org/obo/HP_0011111	Abnormal immune serum protein physiology		Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells.
http://purl.obolibrary.org/obo/HP_0011113	Abnormality of cytokine secretion	http://purl.obolibrary.org/obo/HP_0011111	Abnormal immune serum protein physiology		An abnormality in the production or cellular release of a cytokine (i.e., any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells).
http://purl.obolibrary.org/obo/HP_0011114	Defective production of NFKB1-dependent cytokines	http://purl.obolibrary.org/obo/HP_0011113	Abnormality of cytokine secretion		An impairment in the production by leukocytes of NFKB1-dependent cytokines such as tumor necrosis factor-alpha and interferon-alpha.
http://purl.obolibrary.org/obo/HP_0011115	Abnormal circulating chemokine concentration	http://purl.obolibrary.org/obo/HP_0011112	Abnormal circulating cytokine concentration		An abnormality in the production or cellular release of a chemokine (a class of cytokines).
http://purl.obolibrary.org/obo/HP_0011116	Abnormal circulating interferon concentration	http://purl.obolibrary.org/obo/HP_0011112	Abnormal circulating cytokine concentration		The concentration of an interferon is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration	http://purl.obolibrary.org/obo/HP_0011112	Abnormal circulating cytokine concentration		The concentration of an interleukin (a class of cytokines) is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0011118	Abnormality of tumor necrosis factor secretion	http://purl.obolibrary.org/obo/HP_0011113	Abnormality of cytokine secretion		An abnormality in the production or cellular release of tumor necrosis factor.
http://purl.obolibrary.org/obo/HP_0011120	Concave nasal ridge	http://purl.obolibrary.org/obo/HP_0011119	Abnormal nasal dorsum morphology		Nasal ridge curving posteriorly to an imaginary line that connects the nasal root and tip.
http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		An abnormality of the morphology of the epidermis.
http://purl.obolibrary.org/obo/HP_0011126	Nephroptosis	http://purl.obolibrary.org/obo/HP_0100542	Abnormal localization of kidney		A significant descent of the kidney as the patient moves from the supine to the erect position.
http://purl.obolibrary.org/obo/HP_0011127	Perioral eczema	http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis		A type of eczema that occurs in the lips and perioral area.
http://purl.obolibrary.org/obo/HP_0011128	Acute esophageal necrosis	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		A condition characterized by necrosis of the mucosal and submucosal layers of the esophagus not related to ingestion of caustic or other injurious agents. Endoscopically, there is a dark lesion ('black esophagus') distributed in a circumferential manner in the distal one-third of the esophagus with or without exudates. There is involvement of the distal esophagus ending sharply at the gastroesophageal junction.
http://purl.obolibrary.org/obo/HP_0011129	Bilateral fetal pyelectasis	http://purl.obolibrary.org/obo/HP_0010945	Fetal pyelectasis		A bilateral form of fetal pyelectasis.
http://purl.obolibrary.org/obo/HP_0011130	Abnormal renal calyx morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Any abnormality of the morphology of the major calices or minor calices of the kidney.
http://purl.obolibrary.org/obo/HP_0011131	Perianal dermatitis	http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology		The presence of a rash (change of color and texture) of the perianal skin.
http://purl.obolibrary.org/obo/HP_0011132	Chronic furunculosis	http://purl.obolibrary.org/obo/HP_0005406	Recurrent bacterial skin infections		A furuncle (boil) is a skin infection involving an entire hair follicle and nearby skin tissue. Chronic furunculosis refers to recurrent episodes of furuncles, often caused by recurrent staphylococcus infection.
http://purl.obolibrary.org/obo/HP_0011133	Increased sensitivity to ionizing radiation	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An abnormally increased sensitivity to the effects of ionizing radiation.
http://purl.obolibrary.org/obo/HP_0011134	Low-grade fever	http://purl.obolibrary.org/obo/HP_0001945	Fever		Mild fever that does not exceed 38.5 degrees centigrade.
http://purl.obolibrary.org/obo/HP_0011135	Aplasia/Hypoplasia of the sweat glands	http://purl.obolibrary.org/obo/HP_0000971	Abnormal sweat gland morphology		Absence or developmental hypoplasia of the sweat glands.
http://purl.obolibrary.org/obo/HP_0011136	Aplasia of the sweat glands	http://purl.obolibrary.org/obo/HP_0011135	Aplasia/Hypoplasia of the sweat glands		Absence of the sweat glands.
http://purl.obolibrary.org/obo/HP_0011137	Non-pruritic urticaria	http://purl.obolibrary.org/obo/HP_0011276	Vascular skin abnormality		Pale reddish slightly elevated papules and plaques of 0.5-3 cm in diameter and not accompanied by pruritus.
http://purl.obolibrary.org/obo/HP_0011139	Gastric duplication	http://purl.obolibrary.org/obo/HP_0011140	Gastrointestinal duplication		Gastric duplication is a usually cystic malformation of gastrointestinal tract, usually attached to the greater curvature of the stomach and has no communication with the stomach.
http://purl.obolibrary.org/obo/HP_0011140	Gastrointestinal duplication	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		A spherical hollow structure with a smooth muscle coat, lined by a mucous membrane, and attached to any part of the gastrointestinal tract, from the base of the tongue to the anus.
http://purl.obolibrary.org/obo/HP_0011141	Age-related cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A type of cataract (opacification of the lens) that forms during the course of aging.
http://purl.obolibrary.org/obo/HP_0011142	Age-related nuclear cataract	http://purl.obolibrary.org/obo/HP_0011141	Age-related cataract		A type of age-related cataract that primarily affects the nucleus of the lens.
http://purl.obolibrary.org/obo/HP_0011143	Age-related cortical cataract	http://purl.obolibrary.org/obo/HP_0011141	Age-related cataract		A type of age-related cataract that primarily affects the cortex of the lens.
http://purl.obolibrary.org/obo/HP_0011144	Age-related posterior subcapsular cataract	http://purl.obolibrary.org/obo/HP_0011141	Age-related cataract		A type of age-related cataract consisting of granular opacities occurring mainly in the central posterior cortex just under the posterior capsule.
http://purl.obolibrary.org/obo/HP_0011149	Absence seizure with eyelid myoclonia	http://purl.obolibrary.org/obo/HP_0032678	Eyelid myoclonia seizure		An absence with eyelid myoclonia seizure is a type of generalized non-motor (absence) seizure characterized by forced upward jerking of the eyelids during an absence seizure.
http://purl.obolibrary.org/obo/HP_0011150	Myoclonic absence seizure	http://purl.obolibrary.org/obo/HP_0002121	Generalized non-motor (absence) seizure		Myoclonic absence seizure is a type of generalized non-motor (absence) seizure characterized by an interruption of ongoing activities, a blank stare and rhythmic three-per-second myoclonic movements, causing ratcheting abduction of the upper limbs leading to progressive arm elevation, and associated with 3 Hz generalized spike-wave discharges on the electroencephalogram. Duration is typically 10-60 s. Whilst impairment of consciousness may not be obvious the ILAE classified this seizure as a generalized non-motor seizure in 2017.
http://purl.obolibrary.org/obo/HP_0011151	Atypical absence status epilepticus	http://purl.obolibrary.org/obo/HP_0032860	Generalized non-convulsive status epilepticus without coma		Atypical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged atypical absence seizure.
http://purl.obolibrary.org/obo/HP_0011152	Early onset absence seizures	http://purl.obolibrary.org/obo/HP_0011147	Typical absence seizure		Typical absence seizures starting before the age of 4 years.
http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure	http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure		An autonomic seizure is a type of focal non-motor seizure characterized by alteration of autonomic nervous system function as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure	http://purl.obolibrary.org/obo/HP_0033348	Epileptic aura		A focal sensory seizure is a type seizure beginning with a subjective sensation.
http://purl.obolibrary.org/obo/HP_0011158	Focal sensory seizure with auditory features	http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure		A seizure characterized by elementary auditory phenomena including buzzing, ringing, drumming or single tones as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0011159	Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by symptoms or signs pertaining to the gastrointestinal system as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0011160	Focal sensory seizure with gustatory features	http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure		A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0011161	Focal sensory seizure with olfactory features	http://purl.obolibrary.org/obo/HP_0033693	Phantosmia		Seizures characterized by olfactory phenomena as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0011163	Focal sensory seizure with somatosensory features	http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure		A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0011165	Focal sensory seizure with visual features	http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure		A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colors, or other shapes, simple patterns, scotomata, or amaurosis as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0011166	Focal myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032794	Myoclonic seizure		A type of focal motor seizure characterized by sudden, brief (<100 ms) involuntary single or multiple contraction(s) of muscles(s) or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.
http://purl.obolibrary.org/obo/HP_0011167	Focal tonic seizure	http://purl.obolibrary.org/obo/HP_0032792	Tonic seizure		A type of focal motor seizure characterized by sustained increase in muscle contraction, lasting a few seconds to minutes.
http://purl.obolibrary.org/obo/HP_0011168	Focal seizure with eyelid myoclonia	http://purl.obolibrary.org/obo/HP_0011166	Focal myoclonic seizure		Focal seizure with eyelid myoclonia, not eyelid myoclonias in the context of absence seizures.
http://purl.obolibrary.org/obo/HP_0011169	Generalized clonic seizure	http://purl.obolibrary.org/obo/HP_0032677	Generalized-onset motor seizure		Generalized clonic seizure is a type of generalized motor seizure characterized by sustained bilateral jerking, either symmetric or asymmetric, that is regularly repetitive and involves the same muscle groups.
http://purl.obolibrary.org/obo/HP_0011170	Generalized myoclonic-atonic seizure	http://purl.obolibrary.org/obo/HP_0032677	Generalized-onset motor seizure		A generalized myoclonic-atonic seizure is a type of generalized motor seizure characterized by a myoclonic jerk followed by an atonic motor component.
http://purl.obolibrary.org/obo/HP_0011171	Simple febrile seizure	http://purl.obolibrary.org/obo/HP_0002373	Febrile seizure (within the age range of 3 months to 6 years)		A short generalized seizure, of a duration of <15 min, not recurring within 24 h, occurring during a febrile episode not caused by an acute disease of the nervous system intracranial infection or severe metabolic disturbance.
http://purl.obolibrary.org/obo/HP_0011172	Complex febrile seizure	http://purl.obolibrary.org/obo/HP_0002373	Febrile seizure (within the age range of 3 months to 6 years)		A febrile seizure that has any of the following features: focal semiology (or associated with post-ictal neurologic abnormalities beyond drowsiness, such as a Todd's paresis), prolonged seizure beyond 15 minutes, or recurring (occurring more than once) in a 24 hour period.
http://purl.obolibrary.org/obo/HP_0011173	Focal behavior arrest seizure	http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure		A type of focal non-motor seizure characterized by an arrest or pause of activities, freezing, or immobilization as the predominant semiological feature throughout the seizure.
http://purl.obolibrary.org/obo/HP_0011174	Focal hyperkinetic seizure	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A focal seizure characterized at onset by predominantly proximal limb or axial muscles producing irregular sequential ballistic movements, such as pedaling, pelvic thrusting, thrashing, rocking movements.
http://purl.obolibrary.org/obo/HP_0011175	Focal motor seizure with version	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A type of focal motor seizure characterized by sustained, forced conjugate ocular, cephalic, and/or truncal rotation or lateral deviation from the midline as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0011176	EEG with constitutional variants	http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality		An EEG with constitutional variants contains waves that are rare or unusual but not generally pathologic.
http://purl.obolibrary.org/obo/HP_0011177	EEG with 4-5/second background activity	http://purl.obolibrary.org/obo/HP_0011176	EEG with constitutional variants		EEG background activity at 4-5/second.
http://purl.obolibrary.org/obo/HP_0011178	Alpha-EEG	http://purl.obolibrary.org/obo/HP_0011176	EEG with constitutional variants		EEG dominated by diffuse alpha-waves (8-13Hz).
http://purl.obolibrary.org/obo/HP_0011179	Beta-EEG	http://purl.obolibrary.org/obo/HP_0011202	EEG with diffuse acceleration		EEG dominated by diffuse beta-waves (>13 Hz).
http://purl.obolibrary.org/obo/HP_0011180	Partial beta-EEG	http://purl.obolibrary.org/obo/HP_0011179	Beta-EEG		EEG dominated by diffuse beta waves (>13 Hz) with occipitally localized alpha waves (8-13 Hz).
http://purl.obolibrary.org/obo/HP_0011181	Low voltage EEG	http://purl.obolibrary.org/obo/HP_0011176	EEG with constitutional variants		EEG with an amplitude less than 30 microvolts without observable occipital alpha rhythm (8-13 Hz).
http://purl.obolibrary.org/obo/HP_0011182	Interictal epileptiform activity	http://purl.obolibrary.org/obo/HP_0025373	Interictal EEG abnormality		Epileptiform activity refers to distinctive EEG waves or complexes distinguished from background activity found in in a proportion of human subjects with epilepsy, but which can also be found in subjects without seizures. Interictal epileptiform activity refers to such activity that occurs in the absence of a clinical or subclinical seizure.
http://purl.obolibrary.org/obo/HP_0011183	EEG with hyperventilation-induced focal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0010858	EEG with hyperventilation-induced epileptiform discharges		Focal epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0011184	EEG with hyperventilation-induced generalized epileptiform discharges	http://purl.obolibrary.org/obo/HP_0010858	EEG with hyperventilation-induced epileptiform discharges		Generalized epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011182	Interictal epileptiform activity		EEG discharges recorded in particular areas of a localized (focal) abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).
http://purl.obolibrary.org/obo/HP_0011186	Focal epileptiform discharges with limited propagation to contralateral hemisphere	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform discharges with spreading to contralateral hemisphere but without secondary generalization.
http://purl.obolibrary.org/obo/HP_0011187	Focal EEG discharges with propagation to ipsilateral hemisphere	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform discharges with spreading to the hemisphere on the same side of the brain.
http://purl.obolibrary.org/obo/HP_0011188	Focal EEG discharges with secondary generalization	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal EEG discharges that secondarily spread to both hemispheres and can then be recorded over the entire scalp.
http://purl.obolibrary.org/obo/HP_0011189	Bilateral multifocal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0010841	Multifocal epileptiform discharges		Epileptiform discharges being identified at multiple locations in both hemispheres.
http://purl.obolibrary.org/obo/HP_0011190	Uni- and bilateral multifocal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0010841	Multifocal epileptiform discharges		Epileptiform discharges identified at multiple locations temporarily in both hemispheres and temporarily in one hemisphere.
http://purl.obolibrary.org/obo/HP_0011191	Unilateral multifocal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0010841	Multifocal epileptiform discharges		Epileptiform discharges being identified at multiple locations in one hemisphere.
http://purl.obolibrary.org/obo/HP_0011192	Polymorphic focal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform discharges of different shapes and frequencies.
http://purl.obolibrary.org/obo/HP_0011193	EEG with focal spikes	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		EEG with focal sharp transient waves of a duration less than 80 msec.
http://purl.obolibrary.org/obo/HP_0011194	EEG with series of focal spikes	http://purl.obolibrary.org/obo/HP_0011193	EEG with focal spikes		Focal spikes occurring for several seconds.
http://purl.obolibrary.org/obo/HP_0011195	EEG with focal sharp slow waves	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		EEG with focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011196	EEG with focal sharp waves	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		EEG with focal sharp transient waves of a duration between 80 and 200 msec.
http://purl.obolibrary.org/obo/HP_0011197	EEG with focal spike waves	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		EEG with focal sharp transient waves of a duration less than 80 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011199	EEG with generalized sharp slow waves	http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges		EEG with generalized sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011200	EEG with generalized polymorphic epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges		Generalized epileptiform discharges of different shapes and frequencies.
http://purl.obolibrary.org/obo/HP_0011201	EEG with changes in voltage	http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality		EEG with abnormal amplitude.
http://purl.obolibrary.org/obo/HP_0011202	EEG with diffuse acceleration	http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality		EEG frequency is abnormally increased.
http://purl.obolibrary.org/obo/HP_0011203	EEG with abnormally slow frequencies	http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality		EEG with abnormally slow frequencies.
http://purl.obolibrary.org/obo/HP_0011204	EEG with continuous slow activity	http://purl.obolibrary.org/obo/HP_0010845	EEG with generalized slow activity		EEG showing diffuse slowing without interruption.
http://purl.obolibrary.org/obo/HP_0011205	EEG with intermittent slow activity	http://purl.obolibrary.org/obo/HP_0010845	EEG with generalized slow activity		Non-continuous diffuse slowing of electroencephalographic patterns.
http://purl.obolibrary.org/obo/HP_0011206	EEG with generalized slow activity grade 1	http://purl.obolibrary.org/obo/HP_0010845	EEG with generalized slow activity		Slowing at frequencies between 7.5 and 8.5 Hz.
http://purl.obolibrary.org/obo/HP_0011207	EEG with generalized slow activity grade 2	http://purl.obolibrary.org/obo/HP_0010845	EEG with generalized slow activity		Generalized slowing of EEG activity at frequencies between 4-7 Hz.
http://purl.obolibrary.org/obo/HP_0011208	EEG with generalized slow activity grade 3	http://purl.obolibrary.org/obo/HP_0010845	EEG with generalized slow activity		Generalized slowing of EEG activity at frequencies between 0.5-3 Hz.
http://purl.obolibrary.org/obo/HP_0011209	EEG with generalized slow activity grade 4	http://purl.obolibrary.org/obo/HP_0010845	EEG with generalized slow activity		EEG without electrical activity.
http://purl.obolibrary.org/obo/HP_0011210	EEG with occipital slowing	http://purl.obolibrary.org/obo/HP_0010843	EEG with focal slow activity		Slowing in occipital areas of the scalp EEG.
http://purl.obolibrary.org/obo/HP_0011211	EEG with photoparoxysmal response grade I	http://purl.obolibrary.org/obo/HP_0010852	EEG with photoparoxysmal response		Occurrence of epileptiform discharges in occipital regions during photic stimulation.
http://purl.obolibrary.org/obo/HP_0011212	EEG with photoparoxysmal response grade II	http://purl.obolibrary.org/obo/HP_0010852	EEG with photoparoxysmal response		Occurrence of epileptiform discharges in occipital and central regions during photic stimulation.
http://purl.obolibrary.org/obo/HP_0011213	EEG with photoparoxysmal response grade III	http://purl.obolibrary.org/obo/HP_0010852	EEG with photoparoxysmal response		Occurrence of epileptiform discharges in occipital, central, temporal and parietal regions during photic stimulation.
http://purl.obolibrary.org/obo/HP_0011214	EEG with photoparoxysmal response grade IV	http://purl.obolibrary.org/obo/HP_0010852	EEG with photoparoxysmal response		Occurrence of generalized epileptiform discharges during photic stimulation.
http://purl.obolibrary.org/obo/HP_0011215	Hemihypsarrhythmia	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Hypsarrhythmia occurring in one hemisphere.
http://purl.obolibrary.org/obo/HP_0011219	Short face	http://purl.obolibrary.org/obo/HP_0000274	Small face		Facial height (length) is more than two standard deviations below the mean (objective); or an apparent decrease in the height (length) of the face (subjective).
http://purl.obolibrary.org/obo/HP_0011221	Vertical forehead creases	http://purl.obolibrary.org/obo/HP_0000290	Abnormal forehead morphology		Vertical soft tissue creases in the midline of the forehead, often extending from the hairline to the brow, and seen with facial expression or when the face is at rest.
http://purl.obolibrary.org/obo/HP_0011222	Depressed glabella	http://purl.obolibrary.org/obo/HP_0002056	Abnormality of the glabella		Posterior positioning of the glabella, i.e., of the midline forehead between the supraorbital ridges.
http://purl.obolibrary.org/obo/HP_0011223	Metopic depression	http://purl.obolibrary.org/obo/HP_0005556	Abnormality of the metopic suture		Linear vertical groove in the midline of the forehead, extending from hairline to glabella.
http://purl.obolibrary.org/obo/HP_0011224	Ablepharon	http://purl.obolibrary.org/obo/HP_0011226	Aplasia/Hypoplasia of the eyelid		Absent eyelids.
http://purl.obolibrary.org/obo/HP_0011225	Epiblepharon	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Redundant eyelid skin pressing the eyelashes against the cornea and/or conjunctiva.
http://purl.obolibrary.org/obo/HP_0011226	Aplasia/Hypoplasia of the eyelid	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Absence or underdevelopment of the eyelid.
http://purl.obolibrary.org/obo/HP_0011227	Elevated circulating C-reactive protein concentration	http://purl.obolibrary.org/obo/HP_0032436	Abnormal circulating C-reactive protein concentration		The concentration of C-reactive protein in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0011228	Horizontal eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		An eyebrow that extends straight across the brow, without curve.
http://purl.obolibrary.org/obo/HP_0011229	Broad eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		Regional increase in the width (height) of the eyebrow.
http://purl.obolibrary.org/obo/HP_0011230	Laterally extended eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		An eyebrow that extends laterally beyond the orbital rim rather than turning gently downward at that location.
http://purl.obolibrary.org/obo/HP_0011231	Prominent eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		Eyelashes that draw the attention of the viewer due to increased density and/or length and/or curl without meeting the criteria of trichomegaly.
http://purl.obolibrary.org/obo/HP_0011232	Infra-orbital fold	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Elevated ridge(s) of skin starting well below the medial aspect of the lower lid that curves gradually upward toward and/or across the nasal bridge.
http://purl.obolibrary.org/obo/HP_0011233	Antihelical shelf	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		Antihelix protrusion directed more anteriorly than laterally, forming a shelf overlying the posterior concha.
http://purl.obolibrary.org/obo/HP_0011234	Absent antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		No discernible ridge between concha and triangular fossa and helix.
http://purl.obolibrary.org/obo/HP_0011235	Additional crus of antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		Supernumerary ridge or crus of the ear arising from the antihelix.
http://purl.obolibrary.org/obo/HP_0011236	Angulated antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		Antihelical ridge that forms an acute angle between the antitragus and its bifurcation (stem) instead of a gently curving arc.
http://purl.obolibrary.org/obo/HP_0011237	Broad inferior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011243	Abnormality of inferior crus of antihelix		Increased width of the inferred cross-section of the inferior crus.
http://purl.obolibrary.org/obo/HP_0011238	Prominent inferior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011243	Abnormality of inferior crus of antihelix		Increased protrusion of the inferior crus relative to the prominence of the antihelix stem.
http://purl.obolibrary.org/obo/HP_0011239	Underdeveloped inferior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011243	Abnormality of inferior crus of antihelix		Decreased protrusion of the inferior crus relative to the prominence of the antihelix stem.
http://purl.obolibrary.org/obo/HP_0011240	Prominent stem of antihelix	http://purl.obolibrary.org/obo/HP_0011244	Abnormality of stem of antihelix		Increased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of the helix.
http://purl.obolibrary.org/obo/HP_0011241	Serpiginous stem of antihelix	http://purl.obolibrary.org/obo/HP_0011244	Abnormality of stem of antihelix		Posterior curving of the antihelix from its origin at the antitragus, traveling initially almost perpendicular to the descending helix and obscuring some of the concha.
http://purl.obolibrary.org/obo/HP_0011242	Underdeveloped stem of antihelix	http://purl.obolibrary.org/obo/HP_0011244	Abnormality of stem of antihelix		Decreased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of a normal helix.
http://purl.obolibrary.org/obo/HP_0011243	Abnormality of inferior crus of antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		An abnormality of the inferior crus of the antihelix is the lower cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa.
http://purl.obolibrary.org/obo/HP_0011244	Abnormality of stem of antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		An abnormality of the stem of the antihelix, which is the part below the bifurcation of the antihelix into the inferior and superior crura.
http://purl.obolibrary.org/obo/HP_0011245	Abnormality of superior crus of antihelix	http://purl.obolibrary.org/obo/HP_0009738	Abnormal antihelix morphology		An abnormality of the superior crus of the antihelix is the upper cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa.
http://purl.obolibrary.org/obo/HP_0011246	Underdeveloped superior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011245	Abnormality of superior crus of antihelix		Decreased protrusion of the superior crus relative to the prominence of a normal antihelix stem.
http://purl.obolibrary.org/obo/HP_0011247	Prominent superior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011245	Abnormality of superior crus of antihelix		Increased protrusion of the superior crus relative to the prominence of a normal antihelix stem.
http://purl.obolibrary.org/obo/HP_0011248	Everted antitragus	http://purl.obolibrary.org/obo/HP_0009896	Abnormal antitragus morphology		Positioning of the antitragus at an angle perpendicular to the plane of the ear (oriented away from the plane of the ear).
http://purl.obolibrary.org/obo/HP_0011249	Absent antitragus	http://purl.obolibrary.org/obo/HP_0009896	Abnormal antitragus morphology		Absence of the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix.
http://purl.obolibrary.org/obo/HP_0011250	Bifid antitragus	http://purl.obolibrary.org/obo/HP_0009896	Abnormal antitragus morphology		Double rather than single peak of the antitragus.
http://purl.obolibrary.org/obo/HP_0011251	Underdeveloped antitragus	http://purl.obolibrary.org/obo/HP_0009896	Abnormal antitragus morphology		Reduction in the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix.
http://purl.obolibrary.org/obo/HP_0011252	Cryptotia	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Invagination of the superior part of the auricle under a fold of temporal skin.
http://purl.obolibrary.org/obo/HP_0011253	Type I cryptotia	http://purl.obolibrary.org/obo/HP_0011252	Cryptotia		A type of cryptotia associated with reduction in size of the antihelix and superior crus.
http://purl.obolibrary.org/obo/HP_0011254	Type II cryptotia	http://purl.obolibrary.org/obo/HP_0011252	Cryptotia		A type of cryptotia associated with reduction in size of the antihelix and inferior crus that are affected.
http://purl.obolibrary.org/obo/HP_0011255	Absent crus of helix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		Continuum between the tragus and ascending helix, without any evidence of a posterior extension (crus) towards the concha.
http://purl.obolibrary.org/obo/HP_0011256	Crus of helix connected to antihelix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		Extension of the ridge of the crus helix across the ear and connection of the crus to the antihelix.
http://purl.obolibrary.org/obo/HP_0011257	Serpiginous crus of helix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		Curving course of the crus of the helix, approaching or joining the antitragus.
http://purl.obolibrary.org/obo/HP_0011258	Tragal bridge of crus of helix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		The anterior origin of the crus encompasses the superior margin of the tragus, the crus overrides the upper portion of the conchal cavum and ends at the antihelix.
http://purl.obolibrary.org/obo/HP_0011259	Expanded terminal portion of crus of helix	http://purl.obolibrary.org/obo/HP_0009895	Abnormality of the crus of the helix		Widening, rather than tapering, of the crus at its posterior border near the antihelix.
http://purl.obolibrary.org/obo/HP_0011260	Darwin notch of helix	http://purl.obolibrary.org/obo/HP_0009902	Cleft helix		Small defect of the helical fold that lies at the junction of the superior and descending portions of the helix.
http://purl.obolibrary.org/obo/HP_0011261	Darwin tubercle of helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Small expansion of the helical fold at the junction of the superior and descending portions of the helix.
http://purl.obolibrary.org/obo/HP_0011262	Crimped helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Linear, circumferential indentation in the convexity of the outer surface of the helix.
http://purl.obolibrary.org/obo/HP_0011263	Forward facing earlobe	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Positioning of the anterior surface of the ear lobe in a more coronal plane than the remainder of the ear.
http://purl.obolibrary.org/obo/HP_0011264	Discontinuous ascending root of helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Interruption between the ascending helix and the crus helix, allowing the ascending helix to be attached directly to the mastoid.
http://purl.obolibrary.org/obo/HP_0011265	Cleft earlobe	http://purl.obolibrary.org/obo/HP_0000363	Abnormal earlobe morphology		Discontinuity in the convexity of the inferior margin of the lobe.
http://purl.obolibrary.org/obo/HP_0011266	Microtia, first degree	http://purl.obolibrary.org/obo/HP_0008551	Microtia		Presence of all the normal ear components and the median longitudinal length more than two standard deviations below the mean.
http://purl.obolibrary.org/obo/HP_0011267	Microtia, third degree	http://purl.obolibrary.org/obo/HP_0008551	Microtia		Presence of some auricular structures, but none of these structures conform to recognized ear components.
http://purl.obolibrary.org/obo/HP_0011268	Absent tragus	http://purl.obolibrary.org/obo/HP_0009913	Aplasia/Hypoplasia of the tragus		Lack of convexity or prominence of the contour of the ridge between the bottom of the incisura and the confluence of the ascending helix and crus helix.
http://purl.obolibrary.org/obo/HP_0011269	Bifid tragus	http://purl.obolibrary.org/obo/HP_0009912	Abnormal tragus morphology		Increased height of the tragal ridge with a shallow indentation at the apex, giving the appearance of a double peak.
http://purl.obolibrary.org/obo/HP_0011270	Duplicated tragus	http://purl.obolibrary.org/obo/HP_0009912	Abnormal tragus morphology		A complete or partial duplication of the tragus; expected to lie anterior to the normal tragus.
http://purl.obolibrary.org/obo/HP_0011271	Prominent tragus	http://purl.obolibrary.org/obo/HP_0009912	Abnormal tragus morphology		Increase posterolateral protrusion of the tragus.
http://purl.obolibrary.org/obo/HP_0011272	Underdeveloped tragus	http://purl.obolibrary.org/obo/HP_0009913	Aplasia/Hypoplasia of the tragus		Decreased posterolateral protrusion of the tragus.
http://purl.obolibrary.org/obo/HP_0011273	Anisocytosis	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Abnormally increased variability in the size of erythrocytes.
http://purl.obolibrary.org/obo/HP_0011274	Recurrent mycobacterial infections	http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection		Increased susceptibility to mycobacterial infections as manifested by recurrent episodes of mycobacterial infection.
http://purl.obolibrary.org/obo/HP_0011275	Recurrent mycobacterium avium complex infections	http://purl.obolibrary.org/obo/HP_0011274	Recurrent mycobacterial infections		Increased susceptibility to mycobacterial avium complex infections as manifested by recurrent episodes of mycobacterial infection.
http://purl.obolibrary.org/obo/HP_0011278	Intrapulmonary lobar sequestration	http://purl.obolibrary.org/obo/HP_0100632	Pulmonary sequestration		A type of pulmonary sequestration that occurs within the visceral pleura of normal lung tissue, usually without communication with the tracheobronchial tree.
http://purl.obolibrary.org/obo/HP_0011281	Abnormality of urine catecholamine level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An abnormal amount of urinary catecholamine concentration.
http://purl.obolibrary.org/obo/HP_0011282	Abnormal hindbrain morphology	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		An abnormality of the hindbrain, also known as the rhombencephalon.
http://purl.obolibrary.org/obo/HP_0011284	Short-segment aganglionic megacolon	http://purl.obolibrary.org/obo/HP_0002251	Aganglionic megacolon		A type of aganglionic megacolon in which the aganglionic segment does not extend beyond the upper sigmoid.
http://purl.obolibrary.org/obo/HP_0011285	Long-segment aganglionic megacolon	http://purl.obolibrary.org/obo/HP_0002251	Aganglionic megacolon		A type of aganglionic megacolon in which the aganglionic segment extends proximal to the sigmoid.
http://purl.obolibrary.org/obo/HP_0011286	Total colonic aganglionosis	http://purl.obolibrary.org/obo/HP_0002251	Aganglionic megacolon		A type of aganglionic megacolon in which the aganglionic segment comprises the entire colon.
http://purl.obolibrary.org/obo/HP_0011287	EEG with occipital sharp slow waves	http://purl.obolibrary.org/obo/HP_0033720	EEG with occipital epileptiform discharges		EEG with sharp slow waves in the occipital region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011288	EEG with parietal sharp slow waves	http://purl.obolibrary.org/obo/HP_0033719	EEG with parietal epileptiform discharges		EEG with sharp slow waves in the parietal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011289	EEG with temporal sharp slow waves	http://purl.obolibrary.org/obo/HP_0033717	EEG with temporal epileptiform discharges		EEG with sharp slow waves in the temporal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011290	EEG with frontal sharp slow waves	http://purl.obolibrary.org/obo/HP_0033716	EEG with frontal epileptiform discharges		EEG with sharp slow waves in the frontal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011291	EEG with central sharp slow waves	http://purl.obolibrary.org/obo/HP_0033718	EEG with central epileptiform discharges		EEG with sharp slow waves in the central region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0011292	EEG with occipital sharp waves	http://purl.obolibrary.org/obo/HP_0033720	EEG with occipital epileptiform discharges		EEG with sharp waves in the occipital region, i.e., sharp transient waves of a duration between 80 and 200 msec.
http://purl.obolibrary.org/obo/HP_0011293	EEG with central sharp waves	http://purl.obolibrary.org/obo/HP_0033718	EEG with central epileptiform discharges		EEG with sharp waves in the central region, i.e., sharp transient waves of a duration between 80 and 200 msec.
http://purl.obolibrary.org/obo/HP_0011294	EEG with frontal sharp waves	http://purl.obolibrary.org/obo/HP_0033716	EEG with frontal epileptiform discharges		EEG with sharp waves in the frontal region, i.e., sharp transient waves of a duration between 80 and 200 msec.
http://purl.obolibrary.org/obo/HP_0011295	EEG with parietal sharp waves	http://purl.obolibrary.org/obo/HP_0033719	EEG with parietal epileptiform discharges		EEG with sharp waves in the parietal region, i.e., sharp transient waves of a duration between 80 and 200 msec.
http://purl.obolibrary.org/obo/HP_0011296	EEG with temporal sharp waves	http://purl.obolibrary.org/obo/HP_0033717	EEG with temporal epileptiform discharges		EEG with sharp waves in the temporal region, i.e., sharp transient waves of a duration between 80 and 200 msec.
http://purl.obolibrary.org/obo/HP_0011299	Partial absence of finger	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		The absence of a phalangeal segment of a finger.
http://purl.obolibrary.org/obo/HP_0011300	Broad fingertip	http://purl.obolibrary.org/obo/HP_0001211	Abnormal fingertip morphology		Increased width of the distal segment of a finger.
http://purl.obolibrary.org/obo/HP_0011301	Absent foot	http://purl.obolibrary.org/obo/HP_6000946	Transverse terminal lower limb defect		The total absence of the foot, with no bony elements distal to the tibia or fibula.
http://purl.obolibrary.org/obo/HP_0011302	Long palm	http://purl.obolibrary.org/obo/HP_0100871	Abnormal palm morphology		For children from birth to 16 years of age the length of the palm is more than the 97th centile; or, the length of the palm appears relatively long compared to the finger length or the limb length.
http://purl.obolibrary.org/obo/HP_0011303	Convex contour of sole	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		The contour of the foot in lateral profile has a convex shape.
http://purl.obolibrary.org/obo/HP_0011305	Partial absence of toe	http://purl.obolibrary.org/obo/HP_0010760	Absent toe		The absence of a phalangeal segment of a toe or hallux.
http://purl.obolibrary.org/obo/HP_0011307	Splayed toes	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Divergence of digits along the anteroposterior axis (in the plane of the sole).
http://purl.obolibrary.org/obo/HP_0011308	Slender toe	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Toes that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual.
http://purl.obolibrary.org/obo/HP_0011309	Tapered toe	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		The gradual reduction in girth of the toe from proximal to distal.
http://purl.obolibrary.org/obo/HP_0011310	Bridged palmar crease	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		A crease that connects the proximal and distal transverse palmar creases.
http://purl.obolibrary.org/obo/HP_0011311	Sydney crease	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		Extension of the proximal transverse crease (five finger crease) to the ulnar edge of the palm.
http://purl.obolibrary.org/obo/HP_0011312	Fused nails	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		A nail plate that has a longitudinal separation with partially separated nails, each with a separate lateral radius of curvature.
http://purl.obolibrary.org/obo/HP_0011313	Narrow nail	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		Decreased width of nail.
http://purl.obolibrary.org/obo/HP_0011315	Unicoronal synostosis	http://purl.obolibrary.org/obo/HP_0004440	Coronal craniosynostosis		Synostosis affecting only one of the coronal sutures.
http://purl.obolibrary.org/obo/HP_0011316	Left unicoronal synostosis	http://purl.obolibrary.org/obo/HP_0011315	Unicoronal synostosis		Synostosis affecting only the left coronal suture.
http://purl.obolibrary.org/obo/HP_0011317	Right unicoronal synostosis	http://purl.obolibrary.org/obo/HP_0011315	Unicoronal synostosis		Unicoronal synostosis affecting only the right coronal suture.
http://purl.obolibrary.org/obo/HP_0011318	Bicoronal synostosis	http://purl.obolibrary.org/obo/HP_0004440	Coronal craniosynostosis		Synostosis affecting the right and the left coronal suture.
http://purl.obolibrary.org/obo/HP_0011319	Bilambdoid synostosis	http://purl.obolibrary.org/obo/HP_0004443	Lambdoidal craniosynostosis		Premature synostosis of both lambdoid sutures.
http://purl.obolibrary.org/obo/HP_0011320	Unilambdoid synostosis	http://purl.obolibrary.org/obo/HP_0004443	Lambdoidal craniosynostosis		Premature synostosis of only one lambdoid suture.
http://purl.obolibrary.org/obo/HP_0011321	Left unilambdoid synostosis	http://purl.obolibrary.org/obo/HP_0011320	Unilambdoid synostosis		Premature synostosis of only the left lambdoid suture.
http://purl.obolibrary.org/obo/HP_0011322	Right unilambdoid synostosis	http://purl.obolibrary.org/obo/HP_0011320	Unilambdoid synostosis		Premature synostosis of only the right lambdoid suture.
http://purl.obolibrary.org/obo/HP_0011323	Cleft of chin	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		Incomplete fusion of the chin, resulting from a developmental defect and manifesting as a midline cleft or fissure of the chin.
http://purl.obolibrary.org/obo/HP_0011324	Multiple suture craniosynostosis	http://purl.obolibrary.org/obo/HP_0001363	Craniosynostosis		Craniosynostosis involving at least 2 cranial sutures, where the exact pattern of sutures fused has not been precisely specified.
http://purl.obolibrary.org/obo/HP_0011325	Pansynostosis	http://purl.obolibrary.org/obo/HP_0011324	Multiple suture craniosynostosis		Craniosynostosis of all calvarial sutures.
http://purl.obolibrary.org/obo/HP_0011326	Anterior plagiocephaly	http://purl.obolibrary.org/obo/HP_0001357	Plagiocephaly		Asymmetry of the anterior part of the skull.
http://purl.obolibrary.org/obo/HP_0011327	Posterior plagiocephaly	http://purl.obolibrary.org/obo/HP_0001357	Plagiocephaly		Asymmetry of the posterior part of the skull.
http://purl.obolibrary.org/obo/HP_0011330	Metopic synostosis	http://purl.obolibrary.org/obo/HP_0005556	Abnormality of the metopic suture		Premature fusion of the metopic suture.
http://purl.obolibrary.org/obo/HP_0011331	Hemifacial atrophy	http://purl.obolibrary.org/obo/HP_0000324	Facial asymmetry		Unilateral atrophy of facial tissues, including muscles, bones and skin.
http://purl.obolibrary.org/obo/HP_0011332	Hemifacial hypoplasia	http://purl.obolibrary.org/obo/HP_0000324	Facial asymmetry		Unilateral underdevelopment of the facial tissues, including muscles and bones.
http://purl.obolibrary.org/obo/HP_0011333	Asymmetric crying face	http://purl.obolibrary.org/obo/HP_0000324	Facial asymmetry		Asymmetry observed in the face of a neonate or infant whose face appears symmetric at rest and asymmetric during crying as the mouth is pulled downward on one side while not moving on the other side.
http://purl.obolibrary.org/obo/HP_0011335	Frontal hirsutism	http://purl.obolibrary.org/obo/HP_0009937	Facial hirsutism		Excessive amount of hair growth on forehead.
http://purl.obolibrary.org/obo/HP_0011336	Bitemporal forceps marks	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Bilateral temporal scarlike defects, which are said to resemble forceps marks.
http://purl.obolibrary.org/obo/HP_0011340	Incomplete cleft of the upper lip	http://purl.obolibrary.org/obo/HP_0000204	Cleft upper lip		Cleft of the upper lip that does not go all the way from the bottom of the upper lip until the nasal cavity.
http://purl.obolibrary.org/obo/HP_0011341	Long upper lip	http://purl.obolibrary.org/obo/HP_0000177	Abnormal upper lip morphology		Increased width of the upper lip.
http://purl.obolibrary.org/obo/HP_0011342	Mild global developmental delay	http://purl.obolibrary.org/obo/HP_0001263	Global developmental delay		A mild delay in the achievement of motor or mental milestones in the domains of development of a child.
http://purl.obolibrary.org/obo/HP_0011343	Moderate global developmental delay	http://purl.obolibrary.org/obo/HP_0001263	Global developmental delay		A moderate delay in the achievement of motor or mental milestones in the domains of development of a child.
http://purl.obolibrary.org/obo/HP_0011344	Severe global developmental delay	http://purl.obolibrary.org/obo/HP_0001263	Global developmental delay		A severe delay in the achievement of motor or mental milestones in the domains of development of a child.
http://purl.obolibrary.org/obo/HP_0011345	Moderate expressive language delay	http://purl.obolibrary.org/obo/HP_0002474	Expressive language delay		A moderate delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.
http://purl.obolibrary.org/obo/HP_0011346	Mild expressive language delay	http://purl.obolibrary.org/obo/HP_0002474	Expressive language delay		A mild delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.
http://purl.obolibrary.org/obo/HP_0011348	Abnormal sixth cranial nerve morphology	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		Any structural abnormality of the abducens nerve.
http://purl.obolibrary.org/obo/HP_0011350	Mild receptive language delay	http://purl.obolibrary.org/obo/HP_0010863	Receptive language delay		A mild delay in the acquisition of the ability to understand the speech of others.
http://purl.obolibrary.org/obo/HP_0011351	Moderate receptive language delay	http://purl.obolibrary.org/obo/HP_0010863	Receptive language delay		A moderate delay in the acquisition of the ability to understand the speech of others.
http://purl.obolibrary.org/obo/HP_0011352	Severe receptive language delay	http://purl.obolibrary.org/obo/HP_0010863	Receptive language delay		A severe delay in the acquisition of the ability to understand the speech of others.
http://purl.obolibrary.org/obo/HP_0011353	Arterial intimal fibrosis	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries.
http://purl.obolibrary.org/obo/HP_0011359	Dry hair	http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture		Hair that lacks the luster (shine or gleam) of normal hair.
http://purl.obolibrary.org/obo/HP_0011361	Congenital abnormal hair pattern	http://purl.obolibrary.org/obo/HP_0010720	Abnormal hair pattern		A congenital abnormality of the distribution of hair growth.
http://purl.obolibrary.org/obo/HP_0011364	White hair	http://purl.obolibrary.org/obo/HP_0011358	Generalized hypopigmentation of hair		Hypopigmented hair that appears white.
http://purl.obolibrary.org/obo/HP_0011367	Yellow nails	http://purl.obolibrary.org/obo/HP_0100643	Abnormality of nail color		Yellowish discoloration of the nails.
http://purl.obolibrary.org/obo/HP_0011369	Mongolian blue spot	http://purl.obolibrary.org/obo/HP_0001034	Hypermelanotic macule		Congenital deep dermal melanosis in the sacral area.
http://purl.obolibrary.org/obo/HP_0011371	Recurrent viral skin infections	http://purl.obolibrary.org/obo/HP_0004429	Recurrent viral infections		Increased susceptibility to viral skin infections as manifested by recurrent episodes of viral skin infections.
http://purl.obolibrary.org/obo/HP_0011372	Aplasia of the inner ear	http://purl.obolibrary.org/obo/HP_0008774	Aplasia/Hypoplasia of the inner ear		Absence of the inner ear due to a developmental defect.
http://purl.obolibrary.org/obo/HP_0011374	Incomplete partition of the cochlea type I	http://purl.obolibrary.org/obo/HP_0011373	Incomplete partition of the cochlea		Incomplete partition I is also known as cystic cochleovestibular malformation, where the cochlea has no bony modiolus, resulting in an empty cystic cochlea. This is accompanied by a dilated cystic vestibule with developmental arrest at the fifth week of gestation.
http://purl.obolibrary.org/obo/HP_0011375	Cochlear aplasia	http://purl.obolibrary.org/obo/HP_0011395	Aplasia/Hypoplasia of the cochlea		Absence of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect.
http://purl.obolibrary.org/obo/HP_0011376	Abnormal morphology of the vestibule of the inner ear	http://purl.obolibrary.org/obo/HP_0011390	Abnormal inner ear morphology		A morphological abnormality of the vestibule, the central part of the osseous labyrinth that is situated medial to the tympanic cavity, behind the cochlea, and in front of the semicircular canals.
http://purl.obolibrary.org/obo/HP_0011377	Aplasia of the vestibule	http://purl.obolibrary.org/obo/HP_0011376	Abnormal morphology of the vestibule of the inner ear		Complete absence of the vestibule of the inner ear.
http://purl.obolibrary.org/obo/HP_0011378	Hypoplasia of the vestibule of the inner ear	http://purl.obolibrary.org/obo/HP_0011376	Abnormal morphology of the vestibule of the inner ear		Underdevelopment of the vestibule of the inner ear.
http://purl.obolibrary.org/obo/HP_0011379	Dilated vestibule of the inner ear	http://purl.obolibrary.org/obo/HP_0011376	Abnormal morphology of the vestibule of the inner ear		Dilatation of the vestibule of the inner ear.
http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology	http://purl.obolibrary.org/obo/HP_0011376	Abnormal morphology of the vestibule of the inner ear		An abnormality of the morphology of the semicircular canal.
http://purl.obolibrary.org/obo/HP_0011381	Aplasia of the semicircular canal	http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology		Absence of the semicircular canal.
http://purl.obolibrary.org/obo/HP_0011382	Hypoplasia of the semicircular canal	http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology		Underdevelopment of the semicircular canal.
http://purl.obolibrary.org/obo/HP_0011383	Enlarged semicircular canal	http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology		Increased size of the semicircular canal.
http://purl.obolibrary.org/obo/HP_0011384	Abnormality of the internal auditory canal	http://purl.obolibrary.org/obo/HP_0011390	Abnormal inner ear morphology		An abnormality of the Internal acoustic meatus, i.e., of the canal in the petrous part of the temporal bone through which the cranial nerve VII and cranial nerve VIII traverse.
http://purl.obolibrary.org/obo/HP_0011385	Absent internal auditory canal	http://purl.obolibrary.org/obo/HP_0011384	Abnormality of the internal auditory canal		Aplasia of the internal auditory canal.
http://purl.obolibrary.org/obo/HP_0011386	Narrow internal auditory canal	http://purl.obolibrary.org/obo/HP_0011384	Abnormality of the internal auditory canal		Reduction in diameter of the internal auditory canal.
http://purl.obolibrary.org/obo/HP_0011387	Enlarged vestibular aqueduct	http://purl.obolibrary.org/obo/HP_0011376	Abnormal morphology of the vestibule of the inner ear		Increased size of the vestibular aqueduct.
http://purl.obolibrary.org/obo/HP_0011388	Enlarged cochlear aqueduct	http://purl.obolibrary.org/obo/HP_0000375	Abnormal cochlea morphology		Increased size of the cochlear duct, i.e., of a duct that communicates between the perilymphatic space and the subarachnoid space, and transmits a vein from the cochlea to join the internal jugular.
http://purl.obolibrary.org/obo/HP_0011393	Aplasia of the vestibular nerve	http://purl.obolibrary.org/obo/HP_0011392	Abnormality of the vestibular nerve		Absence of the vestibular nerve
http://purl.obolibrary.org/obo/HP_0011394	Hypoplasia of the vestibular nerve	http://purl.obolibrary.org/obo/HP_0011392	Abnormality of the vestibular nerve		Underdevelopment of the vestibular nerve.
http://purl.obolibrary.org/obo/HP_0011395	Aplasia/Hypoplasia of the cochlea	http://purl.obolibrary.org/obo/HP_0008774	Aplasia/Hypoplasia of the inner ear		Absence or underdevelopment of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect.
http://purl.obolibrary.org/obo/HP_0011396	Abnormality of the cochlear nerve	http://purl.obolibrary.org/obo/HP_0011391	Abnormal inner ear nerve morphology		Any anomaly of the cohclear nerve, which is the part of the vestibulocochlear nerve that is responsible for transmitting auditory signals from the inner ear to the cochlear nuclei within the brainstem and ultimately to the primary auditory cortex within the temporal lobe.
http://purl.obolibrary.org/obo/HP_0011397	Abnormal spinal cord dorsal column morphology	http://purl.obolibrary.org/obo/HP_0020029	Abnormal spinal cord white matter morphology		An abnormality of the dorsal columns, i.e., of the dorsal portion of the gray substance of the spinal cord. The dorsal column consists of the fasciculus gracilis and fasciculus cuneatus and itself is part of the dorsal funiculus.
http://purl.obolibrary.org/obo/HP_0011399	Tibialis anterior muscle atrophy	http://purl.obolibrary.org/obo/HP_0008944	Distal lower limb amyotrophy		Wasting of the tibialis anterior muscle.
http://purl.obolibrary.org/obo/HP_0011401	Delayed peripheral myelination	http://purl.obolibrary.org/obo/HP_0012448	Delayed myelination		Delayed myelination in the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0011402	Demyelinating sensory neuropathy	http://purl.obolibrary.org/obo/HP_0007108	Demyelinating peripheral neuropathy		Demyelination of peripheral sensory nerves.
http://purl.obolibrary.org/obo/HP_0011404	Lethal short-trunk short stature	http://purl.obolibrary.org/obo/HP_0003521	Disproportionate short-trunk short stature		A type of disproportionate short stature characterized by a short trunk but a average-sized limbs that is lethal at birth.
http://purl.obolibrary.org/obo/HP_0011406	Infancy onset short-trunk short stature	http://purl.obolibrary.org/obo/HP_0003521	Disproportionate short-trunk short stature		A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in infancy.
http://purl.obolibrary.org/obo/HP_0011408	Moderate intrauterine growth retardation	http://purl.obolibrary.org/obo/HP_0001511	Intrauterine growth retardation		Intrauterine growth retardation that is at least 3 standard deviations (SD) below average, but not as low as 4 SD, corrected for sex and gestational age.
http://purl.obolibrary.org/obo/HP_0011409	Abnormal placental membrane morphology	http://purl.obolibrary.org/obo/HP_0001194	Abnormalities of placenta or umbilical cord		Structural anomaly of the fetal membranes (also known as the amniochorionic or placental membranes), which comprise a vital intrauterine compartment, where they perform mechanical, immune, and endocrine functions to promote growth of the fetus and protection from environmental adversity. Amniochorionic membranes anatomically consist of a single layer of cuboidal amnion epithelial cells, chorionic trophoblasts, and scattered fibroblasts connected by a layer of type IV collagen-rich extracellular matrix.
http://purl.obolibrary.org/obo/HP_0011410	Caesarean section	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy).
http://purl.obolibrary.org/obo/HP_0011412	Ventouse delivery	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		Delivery of newborn by means of a ventouse, a vacuum device used to assist the delivery of a baby when the second stage of labor has not progressed adequately.
http://purl.obolibrary.org/obo/HP_0011413	Shoulder dystocia	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex.
http://purl.obolibrary.org/obo/HP_0011414	Hydropic placenta	http://purl.obolibrary.org/obo/HP_0006267	Large placenta		An abnormality of the placenta in which there are numerous cystic spaces within the placenta as well as placental enlargement.
http://purl.obolibrary.org/obo/HP_0011417	Long umbilical cord	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Increased length of the umbilical cord.
http://purl.obolibrary.org/obo/HP_0011418	Abnormal insertion of umbilical cord	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Anomalous location of the insertion of umbilical cord in the placenta. Normally, the insertion is at least two centimers distant from the edge of the placenta.
http://purl.obolibrary.org/obo/HP_0011419	Placental abruption	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Separation of the placenta from the uterus wall before delivery.
http://purl.obolibrary.org/obo/HP_0011421	Death in adolescence	http://purl.obolibrary.org/obo/HP_0011420	Age of death		Death during adolescence, the period between childhood and adulthood (roughly between the ages of 10 and 16 years).
http://purl.obolibrary.org/obo/HP_0011423	Hyperchloremia	http://purl.obolibrary.org/obo/HP_0011422	Abnormal circulating chloride concentration		The concentration of chloride in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0011424	Increased serum zinc	http://purl.obolibrary.org/obo/HP_0008277	Abnormal circulating zinc concentration		An increased concentration of zinc in the blood.
http://purl.obolibrary.org/obo/HP_0011426	Fetal choroid plexus cysts	http://purl.obolibrary.org/obo/HP_0034206	Abnormal fetal central nervous system morphology		Fetal choroid plexus cysts (CPCs) are sonographically discrete, small cysts found in the choroid plexus within the lateral cerebral ventricles of the developing fetus at 14 to 24 weeks gestation. Imaging of the choroid plexus is performed in the transverse plane of the fetal head at the same level that the lateral cerebral ventricle is evaluated. The choroid plexus should be inspected bilaterally for the presence of cysts. The size of CPCs is not of clinical relevance (PMID:16100637).
http://purl.obolibrary.org/obo/HP_0011427	Enlarged fetal cisterna magna	http://purl.obolibrary.org/obo/HP_0034206	Abnormal fetal central nervous system morphology		The cisterna magna is measured on a transaxial view of the fetal head angled 15 degrees caudal to the canthomeatal line. The anterior/posterior diameter is taken between the inferior/posterior surface of the vermis of the cerebellum to the inner surface of the cranium. An enlarged cisternal magna is defined by an anterior/posterior diameter of 10 mm or more (PMID:16100637).
http://purl.obolibrary.org/obo/HP_0011428	Short fetal femur length	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		A short femur length is defined as either a measurement below the 2.5th percentile for gestational age or a measurement that is less than 0.9 of that predicted by the measured biparietal diameter. The femur should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637).
http://purl.obolibrary.org/obo/HP_0011429	Short fetal humerus length	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		A short humerus length is defined as a length below the 2.5th percentile for gestational age or as a measurement less than 0.9 of that predicted by the measured biparietal diameter. The humerus should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637).
http://purl.obolibrary.org/obo/HP_0011430	Hypoplasia of fetal nasal bone	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		On prenatal ultrasound, the nasal bone is a thin echogenic line within the bridge of the fetal nose. The fetus is imaged facing the transducer with the fetal face strictly in the midline. The angle of insonation is 90 degrees, with the longitudinal axis of the nasal bone as the reference line. Calibres are placed at each end of the nasal bone. Absence of the nasal bone or measurements below 2.5th percentile are considered significant (PMID:16100637).
http://purl.obolibrary.org/obo/HP_0011431	Fetal fifth finger clinodactyly	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		Fifth finger clinodactyly is defined by a hypoplastic or absent mid-phalanx of the fifth digit. Ultrasound identification of the fetal hand must first be undertaken and then appropriate magnification accomplished. The evaluation requires stretching of the 5 fingers. The diagnosis is established when the middle phalanx of the fifth finger is markedly smaller than normal or absent, which often causes the finger to be curved inward (PMID:16100637).
http://purl.obolibrary.org/obo/HP_0011432	Elevated maternal circulating alpha-fetoprotein concentration	http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening		Increase in the levels of maternal serum alpha-fetoprotein levels during pregnancy.
http://purl.obolibrary.org/obo/HP_0011433	High maternal circulating chorionic gonadotropin concentration	http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening		An abnormally high concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age.
http://purl.obolibrary.org/obo/HP_0011434	Low maternal circulating chorionic gonadotropin concentration	http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening		An abnormally low concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age.
http://purl.obolibrary.org/obo/HP_0011435	Low maternal circulating PAPP-A concentration	http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening		An abnormally low concentration of serum PAPP-A (pregnancy associated plasma protein A), as compared to normal values for gestational-age.
http://purl.obolibrary.org/obo/HP_0011436	Abnormal maternal serum screening	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		An abnormally elevated or decreased level of a maternal serum marker analytes used in screening for aneuploidy.
http://purl.obolibrary.org/obo/HP_0011437	Maternal autoimmune disease	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		A medical history of a fetus or child born to a mother with an autoimmune disease.
http://purl.obolibrary.org/obo/HP_0011438	Maternal teratogenic exposure	http://purl.obolibrary.org/obo/HP_0031437	Pregnancy exposure		A medical history of exposure of the mother of a child or fetus to a teratogenic substance during pregnancy.
http://purl.obolibrary.org/obo/HP_0011439	Anesthetic-induced rhabdomylosis	http://purl.obolibrary.org/obo/HP_0003201	Rhabdomyolysis		Rhabdomyolysis induced by anesthesia.
http://purl.obolibrary.org/obo/HP_0011440	Alcohol-induced rhabdomyolysis	http://purl.obolibrary.org/obo/HP_0003201	Rhabdomyolysis		Rhabdomyolysis induced by intake of alcohol.
http://purl.obolibrary.org/obo/HP_0011441	Abnormal medulla oblongata morphology	http://purl.obolibrary.org/obo/HP_0011282	Abnormal hindbrain morphology		An abnormality of the medulla oblongata, the lower half of the brainstem.
http://purl.obolibrary.org/obo/HP_0011444	Decorticate rigidity	http://purl.obolibrary.org/obo/HP_0002063	Rigidity		A type of rigidity in which the arms are in flexion and adduction and the legs are extended. This signifies a lesion in the cerebral white matter, internal capsules, or thalamus.
http://purl.obolibrary.org/obo/HP_0011445	Athetoid cerebral palsy	http://purl.obolibrary.org/obo/HP_0100021	Cerebral palsy		A type of cerebral palsy characterized by slow, involuntary muscle movement and mixed muscle tone.
http://purl.obolibrary.org/obo/HP_0011447	Hyposegmentation of neutrophil nuclei	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		Hyposegmented (hypolobulated) or bilobed neutrophil nuclei.
http://purl.obolibrary.org/obo/HP_0011448	Ankle clonus	http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology		Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Ankle clonus is tested by rapidly flexing the foot upward.
http://purl.obolibrary.org/obo/HP_0011449	Knee clonus	http://purl.obolibrary.org/obo/HP_0002169	Clonus		Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Knee clonus can be tested by rapidly pushing the patella towards the toes.
http://purl.obolibrary.org/obo/HP_0011451	Primary microcephaly	http://purl.obolibrary.org/obo/HP_0000252	Microcephaly		Head circumference below 2 standard deviations below the mean for age and gender at birth.
http://purl.obolibrary.org/obo/HP_0011453	Abnormal incus morphology	http://purl.obolibrary.org/obo/HP_0004452	Abnormality of the middle ear ossicles		An abnormality of the incus, an ossicle in the middle ear.
http://purl.obolibrary.org/obo/HP_0011454	Abnormal malleus morphology	http://purl.obolibrary.org/obo/HP_0004452	Abnormality of the middle ear ossicles		An abnormality of the malleus, an ossicle in the middle ear.
http://purl.obolibrary.org/obo/HP_0011455	Absent malleus	http://purl.obolibrary.org/obo/HP_0011454	Abnormal malleus morphology		Aplasia of the malleus.
http://purl.obolibrary.org/obo/HP_0011456	Absent stapes	http://purl.obolibrary.org/obo/HP_0008628	Abnormal stapes morphology		Aplasia of the stapes.
http://purl.obolibrary.org/obo/HP_0011457	Loss of eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		This term refers to the loss of eyelashes that were previously present.
http://purl.obolibrary.org/obo/HP_0011459	Esophageal carcinoma	http://purl.obolibrary.org/obo/HP_0100751	Esophageal neoplasm		The presence of a carcinoma of the esophagus.
http://purl.obolibrary.org/obo/HP_0011460	Embryonal onset	http://purl.obolibrary.org/obo/HP_0030674	Antenatal onset		Onset of disease at up to 8 weeks following fertilization (corresponding to 10 weeks of gestation).
http://purl.obolibrary.org/obo/HP_0011461	Fetal onset	http://purl.obolibrary.org/obo/HP_0030674	Antenatal onset		Onset prior to birth but after 8 weeks of embryonic development (corresponding to a gestational age of 10 weeks).
http://purl.obolibrary.org/obo/HP_0011462	Young adult onset	http://purl.obolibrary.org/obo/HP_0003581	Adult onset		Onset of disease at the age of between 16 and 40 years.
http://purl.obolibrary.org/obo/HP_0011463	Childhood onset	http://purl.obolibrary.org/obo/HP_0410280	Pediatric onset		Onset of disease at the age of between 1 and 5 years.
http://purl.obolibrary.org/obo/HP_0011464	Aganglionosis of the small intestine	http://purl.obolibrary.org/obo/HP_0004362	Abnormal enteric ganglion morphology		A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the small intestine.
http://purl.obolibrary.org/obo/HP_0011465	Duodenal aganglionosis	http://purl.obolibrary.org/obo/HP_0011464	Aganglionosis of the small intestine		A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the duodenum.
http://purl.obolibrary.org/obo/HP_0011466	Aplasia/Hypoplasia of the gallbladder	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Absence or underdevelopment of the gallbladder.
http://purl.obolibrary.org/obo/HP_0011467	Absent gallbladder	http://purl.obolibrary.org/obo/HP_0011466	Aplasia/Hypoplasia of the gallbladder		A developmental defect in which the gallbladder fails to form.
http://purl.obolibrary.org/obo/HP_0011468	Facial tics	http://purl.obolibrary.org/obo/HP_0005324	Disturbance of facial expression		Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face.
http://purl.obolibrary.org/obo/HP_0011469	Nasal regurgitation	http://purl.obolibrary.org/obo/HP_0008872	Feeding difficulties in infancy		Regurgitation of milk through the nose.
http://purl.obolibrary.org/obo/HP_0011470	Nasogastric tube feeding in infancy	http://purl.obolibrary.org/obo/HP_0008872	Feeding difficulties in infancy		Feeding problem necessitating nasogastric tube feeding.
http://purl.obolibrary.org/obo/HP_0011471	Gastrostomy tube feeding in infancy	http://purl.obolibrary.org/obo/HP_0008872	Feeding difficulties in infancy		Feeding problem necessitating gastrostomy tube feeding.
http://purl.obolibrary.org/obo/HP_0011473	Villous atrophy	http://purl.obolibrary.org/obo/HP_0011472	Abnormal small intestinal villus morphology		The enteric villi are atrophic or absent.
http://purl.obolibrary.org/obo/HP_0011475	Persistent stapedial artery	http://purl.obolibrary.org/obo/HP_0008609	Abnormal middle ear morphology		Persistence of the stapedial artery, which normally regresses during embryonic life.
http://purl.obolibrary.org/obo/HP_0011476	Profound sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0012715	Profound hearing impairment		Complete loss of hearing related to a sensorineural defect.
http://purl.obolibrary.org/obo/HP_0011477	Upbeat nystagmus	http://purl.obolibrary.org/obo/HP_0010544	Vertical nystagmus		In primary position, the eyes drift slowly downward and then spontaneously beat upward. Upward gaze accentuates the nystagmus. The associated oscillopsias are often very irritating, but the symptoms are usually transient.
http://purl.obolibrary.org/obo/HP_0011478	True anophthalmia	http://purl.obolibrary.org/obo/HP_0000528	Anophthalmia		Absence of globe, optic nerve, chiasm and optic tracts. No evidence of ocular tissue on MRI scan or examination.
http://purl.obolibrary.org/obo/HP_0011480	Unilateral microphthalmos	http://purl.obolibrary.org/obo/HP_0000568	Microphthalmia		A developmental anomaly characterized by abnormal smallness of one eye.
http://purl.obolibrary.org/obo/HP_0011482	Abnormal lacrimal gland morphology	http://purl.obolibrary.org/obo/HP_0000614	Abnormal nasolacrimal system morphology		Abnormality of the lacrimal gland, i.e., of the almond-shaped gland that secretes the aqueous layer of the tear film for each eye.
http://purl.obolibrary.org/obo/HP_0011483	Anterior synechiae of the anterior chamber	http://purl.obolibrary.org/obo/HP_0007833	Anterior chamber synechiae		Adhesions between the iris and the cornea.
http://purl.obolibrary.org/obo/HP_0011484	Posterior synechiae of the anterior chamber	http://purl.obolibrary.org/obo/HP_0007833	Anterior chamber synechiae		Adhesions between the iris and the lens.
http://purl.obolibrary.org/obo/HP_0011485	Corneolenticular adhesion	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		Developmental abnormality in which the lens and cornea are not separated.
http://purl.obolibrary.org/obo/HP_0011486	Abnormal corneal thickness	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		An abnormal anteroposterior thickness of the cornea.
http://purl.obolibrary.org/obo/HP_0011487	Increased corneal thickness	http://purl.obolibrary.org/obo/HP_0011486	Abnormal corneal thickness		A increased anteroposterior thickness of the cornea.
http://purl.obolibrary.org/obo/HP_0011488	Abnormal corneal endothelium morphology	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		Abnormality of the corneal endothelium, that is, the single layer of cells on the inner surface of the cornea.
http://purl.obolibrary.org/obo/HP_0011489	Abnormal migration of corneal endothelium	http://purl.obolibrary.org/obo/HP_0011488	Abnormal corneal endothelium morphology		Abnormal migration of corneal endothelium.
http://purl.obolibrary.org/obo/HP_0011490	Abnormal Descemet membrane morphology	http://purl.obolibrary.org/obo/HP_0011488	Abnormal corneal endothelium morphology		Abnormality of Descemet's membrane, which is the basement membrane of the corneal endothelium.
http://purl.obolibrary.org/obo/HP_0011491	Reduced number of corneal endothelial cells	http://purl.obolibrary.org/obo/HP_0011488	Abnormal corneal endothelium morphology		A reduction in the number of corneal endothelial cells.
http://purl.obolibrary.org/obo/HP_0011492	Abnormal corneal stroma morphology	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		An abnormality of the stroma of cornea, also known as the substantia propria of cornea.
http://purl.obolibrary.org/obo/HP_0011494	Generalized opacification of the cornea	http://purl.obolibrary.org/obo/HP_0007759	Opacification of the corneal stroma		Generalized reduced transparency of the stroma of the cornea.
http://purl.obolibrary.org/obo/HP_0011496	Corneal neovascularization	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		Ingrowth of new blood vessels into the cornea.
http://purl.obolibrary.org/obo/HP_0011497	Rubeosis iridis	http://purl.obolibrary.org/obo/HP_0007905	Abnormal iris vasculature		Formation of new blood vessels on the iris. The new vessels do not display the typical radially symmertic growth pattern of normal iris blood vessels, but rather appear disorganized. Rubeosis usually starts from the pupillary border with tiny tufts of dilated capillaries or red spots that can only be appreciated with high magnification.
http://purl.obolibrary.org/obo/HP_0011499	Mydriasis	http://purl.obolibrary.org/obo/HP_0007686	Abnormal pupillary function		Abnormal dilatation of the iris.
http://purl.obolibrary.org/obo/HP_0011500	Polycoria	http://purl.obolibrary.org/obo/HP_0000615	Abnormal pupil morphology		Multiple pupils.
http://purl.obolibrary.org/obo/HP_0011501	Anterior lenticonus	http://purl.obolibrary.org/obo/HP_0001142	Lenticonus		A conical projection of the anterior surface of the lens, occurring as a developmental anomaly.
http://purl.obolibrary.org/obo/HP_0011502	Posterior lenticonus	http://purl.obolibrary.org/obo/HP_0001142	Lenticonus		A conical projection of the posterior surface of the lens, occurring as a developmental anomaly.
http://purl.obolibrary.org/obo/HP_0011503	Aplasia of the fovea	http://purl.obolibrary.org/obo/HP_0008060	Aplasia/Hypoplasia of the fovea		Congenital absence of the fovea.
http://purl.obolibrary.org/obo/HP_0011504	Bull's eye maculopathy	http://purl.obolibrary.org/obo/HP_0008002	Abnormal macular pigmentation		Progressive maculopathy characterized by concentric regions of hyper- and hypopigmentation, with an initial foveal sparing and whose appearance is said to resemble the central target of a dart board.
http://purl.obolibrary.org/obo/HP_0011505	Cystoid macular edema	http://purl.obolibrary.org/obo/HP_0040049	Macular edema		Cystoid thickening of the retina that takes place due to accumulation of extracellular fluid in the macula as a nonspecific response to blood-retinal barrier breakdown. Histological studies show that radially orientated cystoid spaces consisting of ophthalmoscopically clear fluid are often clinically detectable in the macula area.
http://purl.obolibrary.org/obo/HP_0011506	Choroidal neovascularization	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		Choroidal neovascularization (CNV) is the inward growth of new blood vessels arising from the choriocapillaris. Depending on the stage of development, they can be external (type 1 NV) or internal (type 2 NV) to the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0011507	Macular flecks	http://purl.obolibrary.org/obo/HP_0030500	Yellow/white macular lesion		Pale, often indistinct, multiple lesions of the macula, of variable shape that is not round. The lesions can be notched, angular, or pisciform (said to resemble a fish).
http://purl.obolibrary.org/obo/HP_0011508	Macular hole	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		A macular hole is a full thickness gap in the macula, located in the center of the retina.
http://purl.obolibrary.org/obo/HP_0011509	Macular hyperpigmentation	http://purl.obolibrary.org/obo/HP_0008002	Abnormal macular pigmentation		Increased amount of pigmentation in the macula.
http://purl.obolibrary.org/obo/HP_0011510	Drusen	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in the Bruch membrane of the eye.
http://purl.obolibrary.org/obo/HP_0011511	Macular schisis	http://purl.obolibrary.org/obo/HP_0030502	Retinoschisis		Splitting of the retina in the macular region.
http://purl.obolibrary.org/obo/HP_0011512	Fundus hyperpigmentation	http://purl.obolibrary.org/obo/HP_0031605	Abnormal fundus pigmentation		Increased pigmentation of the fundus
http://purl.obolibrary.org/obo/HP_0011513	Retinal cavernous hemangioma	http://purl.obolibrary.org/obo/HP_0007797	Developmental retinal vascular malformation		A benign tumor of the retina that appears as a grouping of blood-filled saccules within the inner retinal layers or on the surface of the optic disc. Retinal cavernous hemangioma are described as having a 'cluster of grapes' appearance.
http://purl.obolibrary.org/obo/HP_0011515	Abnormal stereopsis	http://purl.obolibrary.org/obo/HP_0011514	Abnormality of binocular vision		Inability to make fine depth discriminations from parallax provided by the two eyes' different positions on the head.
http://purl.obolibrary.org/obo/HP_0011516	Achromatopsia	http://purl.obolibrary.org/obo/HP_0007803	Monochromacy		A condition where the retina contains no functional cone cells, so that in addition to the absence of color discrimination, vision in lights of normal intensity is difficult.
http://purl.obolibrary.org/obo/HP_0011517	Cone monochromacy	http://purl.obolibrary.org/obo/HP_0007803	Monochromacy		The condition of having both rods and cones, but only a single kind of cone. Affected individuals have good pattern vision in daylight, but cannot distinguish between colors.
http://purl.obolibrary.org/obo/HP_0011518	Dichromacy	http://purl.obolibrary.org/obo/HP_0007641	Dyschromatopsia		Individuals affected by dichromacy possess only two types of cones, instead of three.
http://purl.obolibrary.org/obo/HP_0011520	Deuteranomaly	http://purl.obolibrary.org/obo/HP_0011519	Anomalous trichromacy		A type of anomalous trichromacy associated with abnormal M photopigment, such that the absorption spectrum is shifted toward L wavelengths. Affected individuals have difficulties distinguishing between red and green.
http://purl.obolibrary.org/obo/HP_0011521	Deuteranopia	http://purl.obolibrary.org/obo/HP_0011518	Dichromacy		Complete lack of the M photopigment, which is replaced with the L photopigment. Affected individuals tend to confuse red and green.
http://purl.obolibrary.org/obo/HP_0011522	Protanopia	http://purl.obolibrary.org/obo/HP_0011518	Dichromacy		Blue and green cones only; no functional red cones.
http://purl.obolibrary.org/obo/HP_0011523	Iris cyst	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		An iris cyst is composed of a single cell layer of epithelium and is filled with fluid.
http://purl.obolibrary.org/obo/HP_0011524	Iris melanoma	http://purl.obolibrary.org/obo/HP_0007716	Uveal melanoma		Malignant tumor of melanocytes affecting the iris.
http://purl.obolibrary.org/obo/HP_0011525	Iris nevus	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		A benign brown pigmented area over the iris representing proliferation of melanocyte cells in the stromal layer of the iris. An iris nevus can be flat or occasionally slightly elevated.
http://purl.obolibrary.org/obo/HP_0011527	Lentiglobus	http://purl.obolibrary.org/obo/HP_0011526	Abnormality of lens shape		Exaggerated curvature of the lens of the eye, producing an anterior or posterior spherical bulging.
http://purl.obolibrary.org/obo/HP_0011528	Solitary congenital hypertrophy of retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0007649	Congenital hypertrophy of retinal pigment epithelium		Sharply demarcated hyperpigmentation of the retinal pigment epithelium (RPE) that is congenital and of no functional significance.
http://purl.obolibrary.org/obo/HP_0011529	Multiple congenital hypertrophy of retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0007649	Congenital hypertrophy of retinal pigment epithelium		Unilateral or bilateral small, well-demarcated pigmented lesions localized in the retinal pigment epithelium (RPE). Lesions are dark in the center, with a pale circumference and are mostly located in the periphery.
http://purl.obolibrary.org/obo/HP_0011530	Retinal hole	http://purl.obolibrary.org/obo/HP_0011958	Retinal perforation		A full-thickness defect in the retina.
http://purl.obolibrary.org/obo/HP_0011531	Vitritis	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Inflammation of the vitreous body, characterized by the presence of inflammatory cells and protein exudate in the vitreous cavity.
http://purl.obolibrary.org/obo/HP_0011532	Subretinal exudate	http://purl.obolibrary.org/obo/HP_0001147	Retinal exudate		A type of retinal exudate located in the subretinal space between the sensory retina and the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0011533	Snowflake vitreoretinal degeneration	http://purl.obolibrary.org/obo/HP_0007773	Vitreoretinopathy		The appearance of yellow/white crystalline-like (hence the name) spots in the retina and thickening of the peripheral part of the vitreous.
http://purl.obolibrary.org/obo/HP_0011535	Abnormal atrial arrangement	http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments		Abnormality of the spatial relationship of the atria to other components of the heart.
http://purl.obolibrary.org/obo/HP_0011536	Right atrial isomerism	http://purl.obolibrary.org/obo/HP_0031855	Right isomerism		Right atrial isomerism is characterized by bilateral triangular, morphologically right atrial, appendages, both joining the atrial chamber along a broad front with internal terminal crest.
http://purl.obolibrary.org/obo/HP_0011537	Left atrial isomerism	http://purl.obolibrary.org/obo/HP_0031854	Left Isomerism		In left atrial isomerism there is a bilateral small finger-shaped morphologically left atrial appendage joining the atrial chamber along a narrow front without an internal terminal crest.
http://purl.obolibrary.org/obo/HP_0011538	Atrial situs inversus	http://purl.obolibrary.org/obo/HP_0011535	Abnormal atrial arrangement		Mirror image atrial arrangement, with morphologic right atrium on the left hand side and morphologic left atrium on the right hand side.
http://purl.obolibrary.org/obo/HP_0011539	Atrial situs ambiguous	http://purl.obolibrary.org/obo/HP_0011535	Abnormal atrial arrangement		Common atrium without defining morphologic features.
http://purl.obolibrary.org/obo/HP_0011540	Levotransposition of the great arteries	http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments		Congenitally corrected transposition of the great arteries (ccTGA) is a discordance of atrioventricular (AV) and ventriculoarterial connections. The anatomy of ccTGA involves systemic venous drainage to the morphologic right atrium (mRA), which is connected via the mitral valve to the morphologic left ventricle (mLV) whose outflow is the pulmonary arterial system. The pulmonary venous drainage arrives at the morphologic left atrium (mLA), which crosses the tricuspid valve into the morphologic right ventricle (mRV) with outflow into the systemic arterial system. In isolation, ccTGA has an in-series circulation without mixing; therefore, the presence or absence of associated defects dictates the patient's clinical presentation.
http://purl.obolibrary.org/obo/HP_0011541	Criss-cross atrioventricular valves	http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments		Crossing of the inflow streams of the two ventricles, due to an apparent twisting of the heart about its long axis.
http://purl.obolibrary.org/obo/HP_0011542	Criss-cross atrioventricular valves with superior-inferior ventricles	http://purl.obolibrary.org/obo/HP_0011541	Criss-cross atrioventricular valves		Criss-cross atrioventricular valves with a rare cardiac malformation characterized by the two ventricles lying one above the other instead of side by side.
http://purl.obolibrary.org/obo/HP_0011545	Abnormal connection of the cardiac segments	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		A deviance in the normal connections between two cardiac segments.
http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011545	Abnormal connection of the cardiac segments		An abnormality of the circulatory connection between atria and ventricles.
http://purl.obolibrary.org/obo/HP_0011547	Absent left sided atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		A defect where there is no connection between the left atrium and left ventricle.
http://purl.obolibrary.org/obo/HP_0011548	Absent right sided atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		A defect where there is no connection between the right atrium and right ventricle.
http://purl.obolibrary.org/obo/HP_0011552	Ambiguous atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		With left or right cardiac isomerism in a biventricular, the atrioventricular connections are perforce ambiguous, in that one of the connections is concordant (e.g., right-sided morphologic right atrium connected to a morphologic right ventricle) and one of the connections is discordant (e.g., left-sided morphologic right atrium connected to a morphologic left ventricle).
http://purl.obolibrary.org/obo/HP_0011553	Discordant atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		Connection of the right atrium to the left ventricle and of the left atrium to the right ventricle in a biventricular heart.
http://purl.obolibrary.org/obo/HP_0011554	Double inlet atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve.
http://purl.obolibrary.org/obo/HP_0011555	Double inlet left ventricle	http://purl.obolibrary.org/obo/HP_0011554	Double inlet atrioventricular connection		The condition in which both atria are joined to the left ventricle each by its own atrioventricular valve. Usually there is a hypoplastic right ventricle, which may be on the opposite side of the heart as usual.
http://purl.obolibrary.org/obo/HP_0011556	Double inlet right ventricle	http://purl.obolibrary.org/obo/HP_0011554	Double inlet atrioventricular connection		The condition in which both atria are joined to the right ventricle each by its own atrioventricular valve. Usually, the left ventricle is hypoplastic.
http://purl.obolibrary.org/obo/HP_0011557	Double inlet to single ventricle of indeterminate morphology	http://purl.obolibrary.org/obo/HP_0011554	Double inlet atrioventricular connection		The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve. The morphology of this ventricle does not allow one to determine if it corresponds to the left or right ventricle.
http://purl.obolibrary.org/obo/HP_0011560	Mitral atresia	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		A congenital defect with failure to open of the mitral valve orifice.
http://purl.obolibrary.org/obo/HP_0011561	Overriding atrioventricular valve	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		An atrioventricular valve that empties into both ventricles. The valve overrides the interventricular septum above a ventricular septum defect.
http://purl.obolibrary.org/obo/HP_0011562	Straddling atrioventricular valve	http://purl.obolibrary.org/obo/HP_0011546	Abnormal atrioventricular connection		Anomalous insertion of the chordae tendinae or papillary muscles into the contralateral ventricle in the presence of a ventricular septum defect.
http://purl.obolibrary.org/obo/HP_0011564	Mitral valve arcade	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		Anomalous mitral valve arcade is diagnosed based on the following features (1) An adequately sized mitral valve orifice; (2) short, thick, and poorly differentiated chordae with direct union of the papillary muscles to the anterior leaflet; (3) narrow or nearly nonexistent spaces between the abnormal chordae; and (4) greater differentiation of the chordae attached to the posterior papillary muscle.
http://purl.obolibrary.org/obo/HP_0011565	Common atrium	http://purl.obolibrary.org/obo/HP_0005120	Abnormal cardiac atrium morphology		Complete absence of the interatrial septum with common atrioventricular valve and two atrioventricular connections.
http://purl.obolibrary.org/obo/HP_0011566	Cor triatriatum dexter	http://purl.obolibrary.org/obo/HP_0010774	Cor triatriatum		A congenital anomaly with partitioning of the right atrium to form a triatrial heart caused by persistence of the right valve of the sinus venosus. Typically, the right atrial partition is due to exaggerated fetal eustachian and thebesian valves, which together form an incomplete septum across the lower part of the atrium. This septum may range from a reticulum to a substantial sheet of tissue.
http://purl.obolibrary.org/obo/HP_0011567	Sinus venosus atrial septal defect	http://purl.obolibrary.org/obo/HP_0001631	Atrial septal defect		An interatrial communication caused by a deficiency of the common wall between the superior vena cava (SVC) and the right-sided pulmonary veins. SVASD is commonly associated with anomalous pulmonary venous connection (APVC) of some or all of the pulmonary veins, which produces additional left-to-right shunting.
http://purl.obolibrary.org/obo/HP_0011568	Double orifice mitral valve	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		The left atrio-ventricular connection consists of two anatomically distinct orifices separated by accessory fibrous tissue.
http://purl.obolibrary.org/obo/HP_0011569	Cleft anterior mitral valve leaflet	http://purl.obolibrary.org/obo/HP_0031480	Abnormal mitral valve leaflet morphology		Cleft in the anterior mitral valve leaflet not associated with an atrioventricular canal defect.
http://purl.obolibrary.org/obo/HP_0011570	Congenital mitral stenosis	http://purl.obolibrary.org/obo/HP_0001718	Mitral stenosis		Mitral stenosis with congenital onset.
http://purl.obolibrary.org/obo/HP_0011571	Parachute mitral valve	http://purl.obolibrary.org/obo/HP_0025523	Abnormal morphology of the chordae tendinae of the mitral valve		Abnormality of the mitral valve apparatus, whereby chordae attach to a single papillary muscle or hypoplastic papillary muscles.
http://purl.obolibrary.org/obo/HP_0011572	Supramitral ring	http://purl.obolibrary.org/obo/HP_0001633	Abnormal mitral valve morphology		A congenital stenotic mitral valvular anomaly with a ring of tissue above the mitral valve.
http://purl.obolibrary.org/obo/HP_0011573	Hypoplastic tricuspid valve	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		Congenital defect characterized by underdevelopment of the tricuspid valve.
http://purl.obolibrary.org/obo/HP_0011574	Imperforate atrioventricular valve	http://purl.obolibrary.org/obo/HP_0006705	Abnormal atrioventricular valve morphology		An atrioventricular valve that has failed to open (atretic).
http://purl.obolibrary.org/obo/HP_0011575	Imperforate tricuspid valve	http://purl.obolibrary.org/obo/HP_0011574	Imperforate atrioventricular valve		A tricuspid valve that has failed to open.
http://purl.obolibrary.org/obo/HP_0011576	Intermediate atrioventricular canal defect	http://purl.obolibrary.org/obo/HP_0006695	Atrioventricular canal defect		A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and inlet ventricular defect. There is one valve annulus and two valve orifices.
http://purl.obolibrary.org/obo/HP_0011577	Partial atrioventricular canal defect	http://purl.obolibrary.org/obo/HP_0006695	Atrioventricular canal defect		A specific combination of heart defects including a primum atrial septal defect and cleft anterior mitral valve leaflet. There is not an inlet ventricular septal defect present. There are two valve annuluses and two valve orifices.
http://purl.obolibrary.org/obo/HP_0011578	Transitional atrioventricular canal defect	http://purl.obolibrary.org/obo/HP_0006695	Atrioventricular canal defect		A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and an inlet ventricular septal defect. There are two valve annuli and two valve orifices.
http://purl.obolibrary.org/obo/HP_0011579	Unbalanced atrioventricular canal defect	http://purl.obolibrary.org/obo/HP_0006695	Atrioventricular canal defect		Anatomic features of unbalanced atrioventricular septal defect (AVSD) include varying amounts of ventricular hypoplasia, as well as malalignment of the atrioventricular junction. In complete AVSD, the common AV valve can be situated either equally over the right and left ventricles (balanced) or unequally over the ventricles (unbalanced).
http://purl.obolibrary.org/obo/HP_0011580	Short chordae tendineae of the mitral valve	http://purl.obolibrary.org/obo/HP_0025523	Abnormal morphology of the chordae tendinae of the mitral valve		Abnormally short chordae tendineae of the mitral valve.
http://purl.obolibrary.org/obo/HP_0011581	Double outlet left ventricle	http://purl.obolibrary.org/obo/HP_0001711	Abnormal left ventricle morphology		A congenital defect of heart development characterized by origin of both pulmonary artery and aorta from the morphological left ventricle.
http://purl.obolibrary.org/obo/HP_0011582	Abdominal ectopia cordis	http://purl.obolibrary.org/obo/HP_0001683	Ectopia cordis		Displacement of the heart outside the thoracic cavity and into the abdomen.
http://purl.obolibrary.org/obo/HP_0011583	Cervical ectopia cordis	http://purl.obolibrary.org/obo/HP_0001683	Ectopia cordis		A type of ectopia cordis with the heart partially in the cervical region and without a defect of the sternum.
http://purl.obolibrary.org/obo/HP_0011584	Thoracocervical ectopia cordis	http://purl.obolibrary.org/obo/HP_0001683	Ectopia cordis		A type of ectopia cordis with the heart partially in the cervical region with a defect of the superior portion of the sternum.
http://purl.obolibrary.org/obo/HP_0011585	Thoracic ectopia cordis	http://purl.obolibrary.org/obo/HP_0001683	Ectopia cordis		Congenital malformation of the thoracic wall with partial or total displacement of the heart outside the thoracic cavity. This feature is associated with sternal cleft or absence of the sternum.
http://purl.obolibrary.org/obo/HP_0011586	Thoracoabdominal ectopia cordis	http://purl.obolibrary.org/obo/HP_0001683	Ectopia cordis		Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and displacement partially into the abdominal cavity.
http://purl.obolibrary.org/obo/HP_0011587	Abnormal branching pattern of the aortic arch	http://purl.obolibrary.org/obo/HP_0012303	Abnormal aortic arch morphology		A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries.
http://purl.obolibrary.org/obo/HP_0011588	Cervical aortic arch	http://purl.obolibrary.org/obo/HP_0011587	Abnormal branching pattern of the aortic arch		The aortic arch extends into the soft tissues of the neck before turning down into to become the descending aorta.
http://purl.obolibrary.org/obo/HP_0011589	Common origin of the right brachiocephalic artery and left common carotid artery	http://purl.obolibrary.org/obo/HP_0011587	Abnormal branching pattern of the aortic arch		The left common carotid artery has a common origin with the innominate artery.
http://purl.obolibrary.org/obo/HP_0011590	Double aortic arch	http://purl.obolibrary.org/obo/HP_0011587	Abnormal branching pattern of the aortic arch		A conenital abnormality of the aortic arch in which the two embryonic aortc arches form a vascular ring that surrounds the trachea or esophagus and then join to form the descending aorta. Double aortic arch can cause symptoms because of compression of the esophagus (dysphagia, cyanosis while eating) or trachea (stridor).
http://purl.obolibrary.org/obo/HP_0011592	Left aortic arch with isolated subclavian artery	http://purl.obolibrary.org/obo/HP_0031055	Abnormal branching pattern of left aortic arch		The subclavian artery arises from ductus arteriosus. While the ductus arteriosus is patent its blood supply comes from the ductus, hence from the pulmonary artery. After it closes, the blood supply is retrogradely from the vertebral artery via the circle of Willis.
http://purl.obolibrary.org/obo/HP_0011593	Left aortic arch with retroesophageal diverticulum of Kommerell	http://purl.obolibrary.org/obo/HP_0031055	Abnormal branching pattern of left aortic arch		A patent ductus arteriosus or ductal ligament completes the ring.
http://purl.obolibrary.org/obo/HP_0011594	Right aortic arch with retroesophageal diverticulum of Kommerell	http://purl.obolibrary.org/obo/HP_0012020	Right aortic arch		Aortic arch crosses the right mainstem bronchus. The left carotid artery is the first branch, right carotid artery the second branch and right subclavian artery as the third branch.
http://purl.obolibrary.org/obo/HP_0011595	Left aortic arch with retroesophageal right subclavian artery	http://purl.obolibrary.org/obo/HP_0031055	Abnormal branching pattern of left aortic arch		Aortic arch crosses the left mainstem bronchus. The first branch is the right carotid artery, the second branch is the left carotid artery, the third branch is the subclavian artery, the fourth branch is the right subclavian artery arising from the posteromedial aspect of the distal aortic arch and continuing posterior to the esophagus to the right hand side of the body.
http://purl.obolibrary.org/obo/HP_0011596	Left aortic arch with right descending aorta and right ductus arteriosus	http://purl.obolibrary.org/obo/HP_0031055	Abnormal branching pattern of left aortic arch		The ring may be completed by the ductal ligament.
http://purl.obolibrary.org/obo/HP_0011599	Mesocardia	http://purl.obolibrary.org/obo/HP_0004307	Abnormal anatomic location of the heart		Mesocardia is an abnormal location of the heart in which the heart is in a midline position and the longitudinal axis of the heart lies in the mid-sagittal plane.
http://purl.obolibrary.org/obo/HP_0011600	Abnormal direction of ventricular apex	http://purl.obolibrary.org/obo/HP_0004307	Abnormal anatomic location of the heart		Abnormal plane of direction of the heart from the base to the apex. Left sided is normal.
http://purl.obolibrary.org/obo/HP_0011601	Rightward direction of ventricular apex	http://purl.obolibrary.org/obo/HP_0011600	Abnormal direction of ventricular apex		Abnormal plane of direction of the heart from the base to the apex towards the right. Left sided is normal.
http://purl.obolibrary.org/obo/HP_0011602	Midline direction of ventricular apex	http://purl.obolibrary.org/obo/HP_0011600	Abnormal direction of ventricular apex		Abnormal plane of direction of the heart from the base to the apex in the midline. Left sided is normal.
http://purl.obolibrary.org/obo/HP_0011604	Aortopulmonary window	http://purl.obolibrary.org/obo/HP_0011603	Congenital malformation of the great arteries		A congenital anomaly with an abnormal connection between the aorta and the main pulmonary artery resulting in an aortopulmonary shunt.
http://purl.obolibrary.org/obo/HP_0011608	Type II truncus arteriosus	http://purl.obolibrary.org/obo/HP_0001660	Truncus arteriosus		Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with each pulmonary artery arising separate from each other on the posterior or lateral aspect of the truncus.
http://purl.obolibrary.org/obo/HP_0011609	Type III truncus arteriosus	http://purl.obolibrary.org/obo/HP_0001660	Truncus arteriosus		Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby one of the two pulmonary artery branched does not arise from the common pulmonary trunk, but instead from the ductus arteriosus or directly from the aorta.
http://purl.obolibrary.org/obo/HP_0011610	Type IV truncus arteriosus	http://purl.obolibrary.org/obo/HP_0001660	Truncus arteriosus		Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby the aortic arch is hypoplastic or interrupted, and a large patent ductus arteriosus is present.
http://purl.obolibrary.org/obo/HP_0011611	Interrupted aortic arch	http://purl.obolibrary.org/obo/HP_0012303	Abnormal aortic arch morphology		Non-continuity of the arch of aorta with an atretic point or absent segment.
http://purl.obolibrary.org/obo/HP_0011612	Interrupted aortic arch type A	http://purl.obolibrary.org/obo/HP_0011611	Interrupted aortic arch		Non-continuity of the aortic arch with an atretic point or absent segment at the level of the isthmus.
http://purl.obolibrary.org/obo/HP_0011613	Interrupted aortic arch type B	http://purl.obolibrary.org/obo/HP_0011611	Interrupted aortic arch		Non-continuity of the aortic arch with an atretic point or absent segment between the left carotid and subclavian arteries.
http://purl.obolibrary.org/obo/HP_0011614	Interrupted aortic arch type C	http://purl.obolibrary.org/obo/HP_0011611	Interrupted aortic arch		Non-continuity of the aortic arch with an atretic point or absent segment between the innominate and left carotid arteries.
http://purl.obolibrary.org/obo/HP_0011615	Abnormal pulmonary situs morphology	http://purl.obolibrary.org/obo/HP_4000059	Abnormal lung development		An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, which is defined by characteristics such as the number of lobes per lung and the relationship of the pulmonary arteries to their bronchi.
http://purl.obolibrary.org/obo/HP_0011616	Pulmonary situs inversus	http://purl.obolibrary.org/obo/HP_0011615	Abnormal pulmonary situs morphology		Mirror image arrangement of the mainstem bronchi with the right pulmonary artery posterior to the right upper lobe bronchus and the left pulmonary artery anterior to the left upper lobe bronchus.
http://purl.obolibrary.org/obo/HP_0011617	Pulmonary situs ambiguus	http://purl.obolibrary.org/obo/HP_0011615	Abnormal pulmonary situs morphology		An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which the morphology of both left and right lungs is the same.
http://purl.obolibrary.org/obo/HP_0011618	Pulmonary situs ambiguus with bilateral morphologic right lungs	http://purl.obolibrary.org/obo/HP_0011617	Pulmonary situs ambiguus		An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a right lung.
http://purl.obolibrary.org/obo/HP_0011619	Pulmonary situs ambiguus with bilateral morphologic left lungs	http://purl.obolibrary.org/obo/HP_0011617	Pulmonary situs ambiguus		An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a left lung.
http://purl.obolibrary.org/obo/HP_0011621	Gerbode ventricular septal defect	http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect		A type of ventricular septal defect communicating directly between the left ventricle and right atrium. This is anatomically possible because the normal tricuspid valve is more apically displaced than the mitral valve.
http://purl.obolibrary.org/obo/HP_0011622	Inlet ventricular septal defect	http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect		A ventricular septal defect that involves the inlet of the right ventricular septum immediately inferior to the AV valve apparatus.
http://purl.obolibrary.org/obo/HP_0011623	Muscular ventricular septal defect	http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect		The trabecular septum is the largest part of the interventricular septum. It extends from the membranous septum to the apex and superiorly to the infundibular septum. A defect in the trabecular septum is called muscular VSD if the defect is completely rimmed by muscle.
http://purl.obolibrary.org/obo/HP_0011624	Apical muscular ventricular septal defect	http://purl.obolibrary.org/obo/HP_0011623	Muscular ventricular septal defect		A muscular ventricular septal defect located at the apex of the heart.
http://purl.obolibrary.org/obo/HP_0011625	Multiple muscular ventricular septal defects	http://purl.obolibrary.org/obo/HP_0011623	Muscular ventricular septal defect		A type of muscular ventricular septal defect characterized by the presence of multiple small defects in the ventricular septum.
http://purl.obolibrary.org/obo/HP_0011626	Scimitar anomaly	http://purl.obolibrary.org/obo/HP_0010773	Partial anomalous pulmonary venous return		Right pulmonary venous return to the inferior vena cava.
http://purl.obolibrary.org/obo/HP_0011627	Aorto-ventricular tunnel	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinotubular junction to the cavity of the left, or (less commonly) right ventricle.
http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium	http://purl.obolibrary.org/obo/HP_0001697	Abnormal pericardium morphology		A developmental defect of the pericardium with congenital onset.
http://purl.obolibrary.org/obo/HP_0011629	Total absence of the pericardium	http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium		No pericardium around the heart, occurring as a congenital defect, not the result of a surgical pericardectomy.
http://purl.obolibrary.org/obo/HP_0011630	Complete diaphragmatic absence of pericardium	http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium		No pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart.
http://purl.obolibrary.org/obo/HP_0011631	Complete right sided absence of pericardium	http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium		No pericardium is present on the righthand side of the heart. It is a congenital absence of pericardium rather than the result of a pericardectomy.
http://purl.obolibrary.org/obo/HP_0011632	Partial right sided absence of pericardium	http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium		A congenital anomaly with lack of part of the pericardium on the righthand side of the heart.
http://purl.obolibrary.org/obo/HP_0011633	Complete left sided absence of pericardium	http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium		A congenital anomaly with complete lack of the pericardium on the lefthand side of the heart.
http://purl.obolibrary.org/obo/HP_0011634	Partial left sided absence of pericardium	http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium		A congenital anomaly with lack of part of the pericardium on the lefthand side of the heart.
http://purl.obolibrary.org/obo/HP_0011635	Partial diaphragmatic absence of pericardium	http://purl.obolibrary.org/obo/HP_0011628	Congenital defect of the pericardium		Lack of a part of the pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart.
http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin	http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology		Isolated abnormalities of the coronary artery origins. This may be in associated with other structural heart malformations but not the patterns of complex structural heart malformations which result in abnormal course of the coronary arteries.
http://purl.obolibrary.org/obo/HP_0011637	Anomalous origin of coronary artery from the pulmonary artery	http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin		A coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta.
http://purl.obolibrary.org/obo/HP_0011638	Anomalous origin of left coronary artery from the pulmonary artery	http://purl.obolibrary.org/obo/HP_0011637	Anomalous origin of coronary artery from the pulmonary artery		Left main coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the left cusp of the aortic valve.
http://purl.obolibrary.org/obo/HP_0011639	Anomalous origin of right coronary artery from the pulmonary artery	http://purl.obolibrary.org/obo/HP_0011637	Anomalous origin of coronary artery from the pulmonary artery		Right coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the right cusp of the aortic valve.
http://purl.obolibrary.org/obo/HP_0011640	Single coronary artery origin	http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin		The presence of a single coronary artery ostium from which both coronary arteries arise.
http://purl.obolibrary.org/obo/HP_0011641	Coronary artery fistula	http://purl.obolibrary.org/obo/HP_0011686	Abnormal coronary artery course		A congenital malformation with abnormal connection between one of the coronary arteries and a heart chamber or another blood vessel.
http://purl.obolibrary.org/obo/HP_0011642	Abnormal coronary sinus morphology	http://purl.obolibrary.org/obo/HP_0005120	Abnormal cardiac atrium morphology		An abnormality of the coronary sinus, which is formed by the union of the great cardiac vein and the left marginal vein and terminates in the right atrium. The coronary sinus functions to o collect deoxygenated blood from the myocardium of the heart and drain it into the right atrium.
http://purl.obolibrary.org/obo/HP_0011643	Coronary sinus atrial septal defect	http://purl.obolibrary.org/obo/HP_0011642	Abnormal coronary sinus morphology		An atrial septal defect characterized by a deficiency in the tissue separating the coronary sinus from the left atrium (LA). This results in partial or complete unroofing of the coronary sinus leading to a predominantly left-to-right shunt through the coronary sinus (LA to coronary sinus to right atrium [RA]). The orifice of the ostium is frequently large because of the increased flow. From the RA side, the defect is located at the level of the coronary sinus ostium and may also include some deficiency in atrial tissue around the ostium. From the LA side, the size can be variable depending on the degree of unroofing of the coronary sinus. There is partial (either focal or fenestrated) or complete absence of the roof of the CS, which results in a communication between the CS and the LA. Unroofed CS is the rarest type of atrial septal defect. It is often associated with persistent left superior vena cava (LSVC) and other forms of complex congenital heart disease, usually heterotaxia syndromes.
http://purl.obolibrary.org/obo/HP_0011644	Coronary sinus diverticulum	http://purl.obolibrary.org/obo/HP_0011642	Abnormal coronary sinus morphology		A venous pouch within the left ventricular wall, with a neck opening into the coronary sinus.
http://purl.obolibrary.org/obo/HP_0011645	Dilatation of the sinus of Valsalva	http://purl.obolibrary.org/obo/HP_0004970	Ascending tubular aorta aneurysm		Abnormal outpouching or sac-like dilatation of one of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve.
http://purl.obolibrary.org/obo/HP_0011646	Juxtaductal coarctation of the aorta	http://purl.obolibrary.org/obo/HP_0012305	Coarctation of the descending aortic arch		Narrowing or constriction of the aorta localized at the insertion of the ductus arteriosus, i.e., to the juxtaductal region of aortic arch.
http://purl.obolibrary.org/obo/HP_0011647	Postductal coarctation of the aorta	http://purl.obolibrary.org/obo/HP_0012305	Coarctation of the descending aortic arch		Narrowing or constriction of the aorta localized distal to the ductus arteriosus, i.e., to the postductal region of aortic arch.
http://purl.obolibrary.org/obo/HP_0011648	Patent ductus arteriosus after birth at term	http://purl.obolibrary.org/obo/HP_0001643	Patent ductus arteriosus		Abnormal persistent patency of the ductus arteriosus in postnatal life when birth was at 37 completed weeks of gestation or greater.
http://purl.obolibrary.org/obo/HP_0011649	Patent ductus arteriosus after premature birth	http://purl.obolibrary.org/obo/HP_0001643	Patent ductus arteriosus		Abnormal persistent patency of the ductus arteriosus when birth was at less than 37 weeks completed gestation.
http://purl.obolibrary.org/obo/HP_0011650	Bilateral ductus arteriosus	http://purl.obolibrary.org/obo/HP_0001643	Patent ductus arteriosus		The presence of both a left and a right ductus arteriosus.
http://purl.obolibrary.org/obo/HP_0011651	Double outlet right ventricle with doubly committed ventricular septal defect and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a subaortic ventricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011652	Double outlet right ventricle with doubly committed ventricular septal defect without pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a subaortic ventritricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011653	Double outlet right ventricle with non-committed ventricular septal defect and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, and also has a pulmonary stenosis; abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011654	Double outlet right ventricle with non-committed ventricular septal defect without pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, but there is not accompanying pulmonary stenosis; the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011655	Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011656	Double outlet right ventricle with subaortic ventricular septal defect without pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011657	Double outlet right ventricle with subpulmonary ventricular septal defect and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011658	Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001719	Double outlet right ventricle		A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.
http://purl.obolibrary.org/obo/HP_0011659	Tetralogy of Fallot with absent pulmonary valve	http://purl.obolibrary.org/obo/HP_0005134	Absence of the pulmonary valve		Features of tetralogy of Fallot with either rudimentary ridges or the complete absence of pulmonic valve tissue.
http://purl.obolibrary.org/obo/HP_0011660	Anomalous origin of one pulmonary artery from ascending aorta	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Anomalous origin of one pulmonary artery from the ascending aorta with the contralateral pulmonary artery arising from the right ventricle.
http://purl.obolibrary.org/obo/HP_0011661	Anomalous origin of left pulmonary artery from ascending aorta	http://purl.obolibrary.org/obo/HP_0011660	Anomalous origin of one pulmonary artery from ascending aorta		The left pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery.
http://purl.obolibrary.org/obo/HP_0011662	Tricuspid atresia	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		Failure to develop of the tricuspid valve and thus lack of the normal connection between the right atrium and the right ventricle.
http://purl.obolibrary.org/obo/HP_0011663	Right ventricular cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		Right ventricular dysfunction (global or regional) with functional and morphological right ventricular abnormalities, with or without left ventricular disease.
http://purl.obolibrary.org/obo/HP_0011664	Left ventricular noncompaction cardiomyopathy	http://purl.obolibrary.org/obo/HP_0012817	Noncompaction cardiomyopathy		Left ventricular non-compaction (LVNC) is characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer. In some patients, LVNC is associated with left ventricular dilatation and systolic dysfunction, which can be transient in neonates.
http://purl.obolibrary.org/obo/HP_0011665	Takotsubo cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy		Transient left ventricular apical ballooning syndrome or takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction involving the left ventricular apex and/or mid-ventricle in the absence of obstructive coronary disease on coronary angiography. Patients present with an abrupt onset of angina-like chest pain, and have diffuse T-wave inversion, sometimes preceded by ST-segment elevation, and mild cardiac enzyme elevation.
http://purl.obolibrary.org/obo/HP_0011666	Absent right superior vena cava	http://purl.obolibrary.org/obo/HP_0005301	Persistent left superior vena cava		Absence of the right superior vena cava (RSVC). An absent RSVC is always associated with a persistent left superior vena cava (PLSVC). During normal fetal development, the left-sided anterior venous cardinal system regresses, leaving the coronary sinus (CS) and the ligament of Marshall. Failure of the closure of the left anterior cardinal vein results in PLSVC. In general, PLSVC is associated with the right superior vena cava (RSVC) and drains into the RA via a dilated CS. When developmental arrest occurs at an earlier stage, the CS is absent and the PLSVC drains into the left atrium.
http://purl.obolibrary.org/obo/HP_0011669	Left superior vena cava draining directly to the left atrium	http://purl.obolibrary.org/obo/HP_0033379	Bilateral superior vena cava		A persistent left superior vena cava (PLSVC) that drains into the left atrium instead of the right atrium via the coronary sinus, resulting in a right to left sided shunt.
http://purl.obolibrary.org/obo/HP_0011670	Left superior vena cava draining to coronary sinus	http://purl.obolibrary.org/obo/HP_0033379	Bilateral superior vena cava		A persistent left superior vena cava (PLSVC) that drains into the right atrium via the coronary sinus. This is the case in 80-92% of cases of PLSVC and results in no hemodynamic consequence.
http://purl.obolibrary.org/obo/HP_0011671	Interrupted inferior vena cava with azygous continuation	http://purl.obolibrary.org/obo/HP_0025576	Abnormal inferior vena cava morphology		Interrupted inferior vena cava with azygous continuation is the result of connection failure between the right subcardinal vein and the right vitelline vein. Consequently, venous blood from the caudal part of the body reaches the heart via the azygous vein and superior vena cava.
http://purl.obolibrary.org/obo/HP_0011672	Cardiac myxoma	http://purl.obolibrary.org/obo/HP_0100544	Neoplasm of the heart		A myxoma (tumor of primitive connective tissue) of the heart. Cardiac myxomas consist of stellate to plump, cytologically bland mesenchymal cells set in a myxoid stroma. Cardiac myxomas are of endocardial origin and general project from the endocardium into a cardiac chamber.
http://purl.obolibrary.org/obo/HP_0011673	Cardiac hemangioma	http://purl.obolibrary.org/obo/HP_0410266	Visceral hemangioma		Abnormal proliferation of blood vessels within the cardiac cavities attached to the endocardium.
http://purl.obolibrary.org/obo/HP_0011674	Cardiac teratoma	http://purl.obolibrary.org/obo/HP_0100544	Neoplasm of the heart		A teratoma within the heart. Most commonly, these tumors are detected in the pericardial cavity attached to the pulmonary artery and aorta. The tumor size within the heart varies from 2 to 9 cm in diameter, and intrapericardial tumors as large as 15 cm have been reported. Intracardiac tumors arise from the atrial or ventricular wall as nodular masses protruding into the cardiac chambers. Cardiac and pericardial teratomas are easily detected in the fetus and neonate by two-dimensional echocardiography as heterogeneous and encapsulated cystic masses. Histologically, cardiac teratomas contain multiple immature elements including epithelium, neuroglial tissue, thyroid, pancreas, smooth and skeletal muscle, cartilage and bone.
http://purl.obolibrary.org/obo/HP_0011678	Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral arteries	http://purl.obolibrary.org/obo/HP_0012516	Tetralogy of Fallot with pulmonary atresia		A type of tetralogy of Fallot with pulmonary atresia in which all pulmonary blood flow is derived from major aortopulmonary collateral arteries (MAPCA).
http://purl.obolibrary.org/obo/HP_0011679	Tetralogy of Fallot with pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001636	Tetralogy of Fallot		The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus.
http://purl.obolibrary.org/obo/HP_0011681	Subarterial ventricular septal defect	http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect		A ventricular septal defect that lies beneath the semilunar valve(s) in the conal or outlet septum.
http://purl.obolibrary.org/obo/HP_0011682	Perimembranous ventricular septal defect	http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect		A ventricular septal defect that is confluent with and involves the membranous septum and is bordered by an atrioventricular valve, not including the type 3 VSDs.
http://purl.obolibrary.org/obo/HP_0011683	Restrictive ventricular septal defect	http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect		Any ventricular septal defect (VSD) that is small enough to restrict flow across it such that a pressure gradient exists between the two sides of the VSD.
http://purl.obolibrary.org/obo/HP_0011684	Non-restrictive ventricular septal defect	http://purl.obolibrary.org/obo/HP_0001629	Ventricular septal defect		Any ventricular septal defect (VSD) that does not restrict flow across it sufficiently to generate a pressure gradient between the two sides of the VSD.
http://purl.obolibrary.org/obo/HP_0011685	Infra-aortic superior vena cava	http://purl.obolibrary.org/obo/HP_0025575	Abnormal superior vena cava morphology		The superior vena cava passes below the aortic arch.
http://purl.obolibrary.org/obo/HP_0011686	Abnormal coronary artery course	http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology		An abnormal path of a coronary artery.
http://purl.obolibrary.org/obo/HP_0011687	AV nodal tachycardia	http://purl.obolibrary.org/obo/HP_0004755	Supraventricular tachycardia		A type of supraventricular tachycardia that originates in the atrioventricular node.
http://purl.obolibrary.org/obo/HP_0011688	Supraventricular tachycardia with an accessory connection mediated pathway	http://purl.obolibrary.org/obo/HP_0004755	Supraventricular tachycardia		Supraventricular tachycardia in which an accessory pathway connecting the atria and ventricles, apart from the AV node, participates as a necessary part of a reentrant mechanism.
http://purl.obolibrary.org/obo/HP_0011689	Supraventricular tachycardia with a concealed accessory connection	http://purl.obolibrary.org/obo/HP_0011688	Supraventricular tachycardia with an accessory connection mediated pathway		Supraventricular tachycardia with an accessory connection mediated pathway that is called concealed because it is not seen on the ECG during sinus rhythm.
http://purl.obolibrary.org/obo/HP_0011690	Permanent junctional reciprocating tachycardia	http://purl.obolibrary.org/obo/HP_0011689	Supraventricular tachycardia with a concealed accessory connection		An incessant orthodromic tachycardia with anterograde conduction over the atrioventricular node and by retrograde conduction via an accessory pathway usually located in the posteroseptal region with slow and decremental conduction.
http://purl.obolibrary.org/obo/HP_0011695	Cerebellar hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial hemorrhage		Hemorrhage into the parenchyma of the cerebellum.
http://purl.obolibrary.org/obo/HP_0011700	Automatic atrial tachycardia	http://purl.obolibrary.org/obo/HP_0001692	Atrial arrhythmia		Chronic supraventricular tachycardia predominantly seen in childhood.
http://purl.obolibrary.org/obo/HP_0011701	Multifocal atrial tachycardia	http://purl.obolibrary.org/obo/HP_0001692	Atrial arrhythmia		Multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic.
http://purl.obolibrary.org/obo/HP_0011703	Sinus tachycardia	http://purl.obolibrary.org/obo/HP_0001649	Tachycardia		Heart rate of greater than 100 beats per minute.
http://purl.obolibrary.org/obo/HP_0011704	Sick sinus syndrome	http://purl.obolibrary.org/obo/HP_0012722	Heart block		An abnormality involving the generation of the action potential by the sinus node and is characterized by an atrial rate inappropriate for physiological requirements. Manifestations include severe sinus bradycardia, sinus pauses or arrest, sinus node exit block, chronic atrial tachyarrhythmias, alternating periods of atrial bradyarrhythmias and tachyarrhythmias, and inappropriate responses of heart rate during exercise or stress.
http://purl.obolibrary.org/obo/HP_0011705	First degree atrioventricular block	http://purl.obolibrary.org/obo/HP_0001678	Atrioventricular block		Delay of conduction through the atrioventricular node, which is manifested as prolongation of the PR interval in the electrocardiogram (EKG). All atrial impulses reach the ventricles.
http://purl.obolibrary.org/obo/HP_0011706	Second degree atrioventricular block	http://purl.obolibrary.org/obo/HP_0001678	Atrioventricular block		An intermittent atrioventricular block with failure of some atrial impulses to conduct to the ventricles, i.e., some but not all atrial impulses are conducted through the atrioventricular node and trigger ventricular contraction.
http://purl.obolibrary.org/obo/HP_0011707	Mobitz I atrioventricular block	http://purl.obolibrary.org/obo/HP_0011706	Second degree atrioventricular block		Progressive PR interval prolongation with the subsequent occurrence of a single nonconducted P wave that results in a pause. The pause that follows the nonconducted impulse is less than fully compensatory (less than the sum of two normal sinus intervals).
http://purl.obolibrary.org/obo/HP_0011708	Mobitz II atrioventricular block	http://purl.obolibrary.org/obo/HP_0011706	Second degree atrioventricular block		A type of second degree atrioventricular (AV) block characterized by sudden failure to conduct an impulse through the AV node without a preceding change in the PR interval.
http://purl.obolibrary.org/obo/HP_0011709	Atrioventricular dissociation	http://purl.obolibrary.org/obo/HP_0005150	Abnormal atrioventricular conduction		Atrioventricular (AV) dissociation is present if the atria and the ventricles are under the control of two separate pacemakers. AV dissociation can occur in the absence of a primary AV conduction disturbance.
http://purl.obolibrary.org/obo/HP_0011710	Bundle branch block	http://purl.obolibrary.org/obo/HP_0012722	Heart block		Block of conduction of electrical impulses along the Bundle of His or along one of its bundle branches.
http://purl.obolibrary.org/obo/HP_0011711	Left anterior fascicular block	http://purl.obolibrary.org/obo/HP_0011713	Left bundle branch block		Conduction block in the anterior division of the left bundle branch of the bundle of His.
http://purl.obolibrary.org/obo/HP_0011712	Complete right bundle branch block	http://purl.obolibrary.org/obo/HP_0011710	Bundle branch block		A conduction block of the right branch of the bundle of His. This manifests as a prolongation of the QRS complex (greater than 0.12 s) with delayed activation of the right ventricle and terminal delay on the EKG.
http://purl.obolibrary.org/obo/HP_0011713	Left bundle branch block	http://purl.obolibrary.org/obo/HP_0011710	Bundle branch block		A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG.
http://purl.obolibrary.org/obo/HP_0011714	Libman-Sacks lesions	http://purl.obolibrary.org/obo/HP_0100584	Endocarditis		Libman-Sacks valvular lesions are sterile fibrofibrinous vegetations that favor the left-sided heart valves and usually form on the ventricular surface of the mitral valve.
http://purl.obolibrary.org/obo/HP_0011715	Trifascicular block	http://purl.obolibrary.org/obo/HP_0011710	Bundle branch block		Abnormal conduction in all three divisions of the intraventricular conducting tissue.
http://purl.obolibrary.org/obo/HP_0011716	Junctional ectopic tachycardia	http://purl.obolibrary.org/obo/HP_0011687	AV nodal tachycardia		Junctional ectopic tachycardia (JET) is a unique type of supraventricular arrhythmia defined by narrow QRS complex and atrioventricular (AV) dissociation or retrograde atrial conduction in a 1:1 pattern.
http://purl.obolibrary.org/obo/HP_0011717	Atrioventricular reentrant tachycardia	http://purl.obolibrary.org/obo/HP_0011687	AV nodal tachycardia		Accessory pathway-related atrioventricular reentrant tachycardia (AVRT) involves an abnormal electrical conduction of the accessory pathway. The accessory pathway connecting impulses between the atrium and the ventricle can be seen at any site in the AV groove.
http://purl.obolibrary.org/obo/HP_0011718	Abnormality of the pulmonary veins	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		An abnormality of the pulmonary veins.
http://purl.obolibrary.org/obo/HP_0011719	Supracardiac total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0005160	Total anomalous pulmonary venous return		Type 1 total anomalous pulmonary venous connection.
http://purl.obolibrary.org/obo/HP_0011720	Cardiac total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0005160	Total anomalous pulmonary venous return		Type 2 total anomalous pulmonary venous connection.
http://purl.obolibrary.org/obo/HP_0011721	Infracardiac total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0005160	Total anomalous pulmonary venous return		Type 3 total anomalous pulmonary venous connection.
http://purl.obolibrary.org/obo/HP_0011722	Mixed total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0005160	Total anomalous pulmonary venous return		Type 4 total anomalous pulmonary venous connection.
http://purl.obolibrary.org/obo/HP_0011724	Uhl's anomaly	http://purl.obolibrary.org/obo/HP_0011723	Congenital malformation of the right heart		Uhl anomaly of the right ventricle refers to the almost complete absence of right ventricular myocardium, normal tricuspid valve, and preserved septal and left ventricular myocardium.
http://purl.obolibrary.org/obo/HP_0011726	Persistent fetal circulation	http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology		Systemic desaturation of a liveborn baby resulting from persistent pulmonary hypertension with a patent ductus arteriosus and patent foramen ovale, such that the circulation in postnatal life follows the fetal course.
http://purl.obolibrary.org/obo/HP_0011727	Peroneal muscle weakness	http://purl.obolibrary.org/obo/HP_0009053	Distal lower limb muscle weakness		Weakness of the peroneal muscles.
http://purl.obolibrary.org/obo/HP_0011728	Elbow clonus	http://purl.obolibrary.org/obo/HP_0002169	Clonus		Clonus at the elbow joint, i.e., an exaggerated phasic stretch reflex characterized by repetitive, rhythmic contractions at the elbow, generated by rapid passive stretch at the elbow joint.
http://purl.obolibrary.org/obo/HP_0011730	Abnormal central sensory function	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An abnormality of sensation related to CNS function. Assuming the primary sensory modalities are intact and the patient is alert and cooperative, the presence of an abnormality of sensory function may indicate a lesion of a parietal cortex, the thalamocortical projections to the parietal cortex, or the spinal cord.
http://purl.obolibrary.org/obo/HP_0011734	Central adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0000846	Adrenal insufficiency		A form of adrenal insufficiency related to a lack of ACTH, which leads to a decrease in the production of cortisol by the adrenal glands. Aldosterone production is not usually affected.
http://purl.obolibrary.org/obo/HP_0011735	Adrenocorticotropin deficient adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0011734	Central adrenal insufficiency		Adrenal insufficiency secondary to a defect in ACTH production.
http://purl.obolibrary.org/obo/HP_0011736	Primary hyperaldosteronism	http://purl.obolibrary.org/obo/HP_0000859	Increased circulating aldosterone concentration		A form of hyperaldosteronism caused by a defect within the adrenal gland.
http://purl.obolibrary.org/obo/HP_0011737	Corticotropin-releasing hormone deficient adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0011734	Central adrenal insufficiency		Adrenal insufficiency secondary to a defect in corticotropin-releasing hormone production.
http://purl.obolibrary.org/obo/HP_0011738	Corticotropin-releasing hormone receptor defect	http://purl.obolibrary.org/obo/HP_0011734	Central adrenal insufficiency		Adrenal insufficiency secondary to a defect in the corticotropin-releasing hormone receptor.
http://purl.obolibrary.org/obo/HP_0011739	Dexamethasone-suppressible primary hyperaldosteronism	http://purl.obolibrary.org/obo/HP_0011736	Primary hyperaldosteronism		A form of primary hyperaldosteronism in which the overproduction of aldosterone can be suppressed by the administration of dexamethasone.
http://purl.obolibrary.org/obo/HP_0011740	Glucocortocoid-insensitive primary hyperaldosteronism	http://purl.obolibrary.org/obo/HP_0011736	Primary hyperaldosteronism		A form of primary hyperaldosteronism in which the overproduction of aldosterone cannot be suppressed by the administration of dexamethasone or similar glucocorticoids.
http://purl.obolibrary.org/obo/HP_0011741	Secondary hyperaldosteronism	http://purl.obolibrary.org/obo/HP_0000859	Increased circulating aldosterone concentration		A form of hyperaldosteronism caused by abnormally increased renin levels.
http://purl.obolibrary.org/obo/HP_0011742	Ectopic adrenal gland	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Abnormal anatomical location of the adrenal gland.
http://purl.obolibrary.org/obo/HP_0011743	Adrenal gland agenesis	http://purl.obolibrary.org/obo/HP_0008216	Adrenal gland dysgenesis		Absent development of the adrenal gland.
http://purl.obolibrary.org/obo/HP_0011744	Secondary hypercortisolism	http://purl.obolibrary.org/obo/HP_0003118	Increased circulating cortisol level		Hypercortisolemia associated with a overproduction of ACTH (often from a tumor), leading secondarily to overproduction of cortisol.
http://purl.obolibrary.org/obo/HP_0011745	Non-secretory adrenocortical adenoma	http://purl.obolibrary.org/obo/HP_0008256	Adrenocortical adenoma		An hormonally inactive adrenocortical adenoma, that is, an adenoma that does not secrete excessive amounts of adrenal hormones.
http://purl.obolibrary.org/obo/HP_0011746	Secretory adrenocortical adenoma	http://purl.obolibrary.org/obo/HP_0008256	Adrenocortical adenoma		An hormonally active adrenocortical adenoma, that is, an adenoma that secretes excessive amounts of adrenal hormones.
http://purl.obolibrary.org/obo/HP_0011748	Adrenocorticotropic hormone deficiency	http://purl.obolibrary.org/obo/HP_0000830	Anterior hypopituitarism		A reduced ability to secrete adrenocorticotropic hormone (ACTH), a hormone that stimulates the adrenal cortex to secrete of glucocorticoids such as cortisol.
http://purl.obolibrary.org/obo/HP_0011749	Adrenocorticotropic hormone excess	http://purl.obolibrary.org/obo/HP_0010514	Hyperpituitarism		Overproduction of adrenocorticotropic hormone (ACTH), which generally leads secondarily to overproduction of cortisol by the adrenal cortex.
http://purl.obolibrary.org/obo/HP_0011752	Neoplasm of the posterior pituitary	http://purl.obolibrary.org/obo/HP_0011751	Abnormal posterior pituitary morphogenesis		The presence of a neoplasm (tumor) in the neurohypophysis, which is also known as the posterior lobe of the hypophysis.
http://purl.obolibrary.org/obo/HP_0011753	Posterior pituitary dysgenesis	http://purl.obolibrary.org/obo/HP_0011751	Abnormal posterior pituitary morphogenesis		Abnormal development of the neurohypophysis during embryonic growth and development.
http://purl.obolibrary.org/obo/HP_0011754	Pituicytoma	http://purl.obolibrary.org/obo/HP_0011752	Neoplasm of the posterior pituitary		A solid, low grade, spindle cell, glial neoplasm of adults that originates in the neurohypophysis or infundibulum. Clinical signs and symptoms include visual disturbance, headache and features of hypopituitarism. Pituicytomas are well-circumscribed, solid masses that can measure up to several centimeters. Histologically, they show a compact architecture consisting of elongate, bipolar spindle cells arranged in interlacing fascicles or assuming a storiform pattern.
http://purl.obolibrary.org/obo/HP_0011755	Ectopic posterior pituitary	http://purl.obolibrary.org/obo/HP_0011753	Posterior pituitary dysgenesis		An abnormal anatomical location of the posterior lobe of the hypophysis, also known as the neurohypophysis. The posterior pituitary is normally present in the dorsal portion of the sella turcica, but when ectopic is usually near the median eminence. This defect is likely to be due to abnormal migration during embryogenesis.
http://purl.obolibrary.org/obo/HP_0011756	Posterior pituitary agenesis	http://purl.obolibrary.org/obo/HP_0011753	Posterior pituitary dysgenesis		Absence of the neurohypophysis owing to a developmental defect.
http://purl.obolibrary.org/obo/HP_0011757	Posterior pituitary hypoplasia	http://purl.obolibrary.org/obo/HP_0011753	Posterior pituitary dysgenesis		Underdevelopment of the neurohypophysis.
http://purl.obolibrary.org/obo/HP_0011759	Pituitary gonadotropic cell adenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A type of pituitary adenoma that produces gonadotropins.
http://purl.obolibrary.org/obo/HP_0011760	Pituitary growth hormone cell adenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A type of pituitary adenoma that produces growth hormone.
http://purl.obolibrary.org/obo/HP_0011761	Pituitary null cell adenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess.
http://purl.obolibrary.org/obo/HP_0011762	Pituitary thyrotropic cell adenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A type of pituitary adenoma that produces thyroid stimulating hormone (TSH).
http://purl.obolibrary.org/obo/HP_0011763	Pituitary carcinoma	http://purl.obolibrary.org/obo/HP_0011750	Neoplasm of the anterior pituitary		A pituitary tumor with subarachnoid, brain, or systemic metastasis. The diagnosis of a pituitary carcinoma requires evidence of metastatic disease, either outside the central nervous system (CNS) or as separate noncontiguous foci within the CNS.
http://purl.obolibrary.org/obo/HP_0011764	Pituitary spindle cell oncocytoma	http://purl.obolibrary.org/obo/HP_0011750	Neoplasm of the anterior pituitary		A spindled-to-epithelioid, oncocytic, nonendocrine neoplasm of the anterior hypophysis that manifests in adults and follows a benign clinical course. Pituitary spindle cell oncocytomas are firm, fibrous, and adherent to surrounding structures and are highly vascular.
http://purl.obolibrary.org/obo/HP_0011766	Abnormal parathyroid morphology	http://purl.obolibrary.org/obo/HP_0000828	Abnormality of the parathyroid gland		A structural abnormality of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0011769	Ectopic parathyroid	http://purl.obolibrary.org/obo/HP_0011768	Parathyroid dysgenesis		An abnormal anatomical location of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0011770	Tertiary hyperparathyroidism	http://purl.obolibrary.org/obo/HP_0000843	Hyperparathyroidism		A type of hyperparathyroidism that occurs following kidney transplantation, which is a treatment for secondary hyperparathyroidism. Although kidney transplantation leads to a normalization of serum calcium and parathyroid hormone in most patients. The state of persistent hypercalcemia and hyperparathyroidism is referred to as tertiary hyperparathyroidism.
http://purl.obolibrary.org/obo/HP_0011771	Autoimmune hypoparathyroidism	http://purl.obolibrary.org/obo/HP_0002960	Autoimmunity		A type of hypoparathyroidism with circulating antiparathyroid or anti-calcium sensing receptor antibodies indicative of autoimmunity.
http://purl.obolibrary.org/obo/HP_0011773	Uninodular goiter	http://purl.obolibrary.org/obo/HP_0005994	Nodular goiter		Enlargement of the thyroid gland related to a singular nodule in the thyroid gland.
http://purl.obolibrary.org/obo/HP_0011780	Thyroid hemiagenesis	http://purl.obolibrary.org/obo/HP_0033079	Aplasia/Hypoplasia of the thyroid gland		Absence of a lobe of the thyroid gland related to a failure of its embryologic development.
http://purl.obolibrary.org/obo/HP_0011781	Thyroid C cell hyperplasia	http://purl.obolibrary.org/obo/HP_0008249	Thyroid hyperplasia		An abnormal growth of parafollicular (C-cells) cells.
http://purl.obolibrary.org/obo/HP_0011787	Central hypothyroidism	http://purl.obolibrary.org/obo/HP_0000821	Hypothyroidism		A type of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland. Central hypothyroidism is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects.
http://purl.obolibrary.org/obo/HP_0011788	Increased circulating free T3	http://purl.obolibrary.org/obo/HP_0032209	Abnormal circulating free T3 concentration		An elevated concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0011789	Impaired sensitivity to thyroid stimulating hormone	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		Reduced sensitivity of thyroid follicle cells to stimulation by biologically active thyroid-stimulating hormone (TSH).
http://purl.obolibrary.org/obo/HP_0011790	Activating thyroid-stimulating hormone receptor defect	http://purl.obolibrary.org/obo/HP_0011789	Impaired sensitivity to thyroid stimulating hormone		Gain-of-function thyroid-stimulating hormone receptor (TSHR) defect.
http://purl.obolibrary.org/obo/HP_0011791	Inactivating thyroid-stimulating hormone receptor defect	http://purl.obolibrary.org/obo/HP_0011789	Impaired sensitivity to thyroid stimulating hormone		Loss-of-function thyroid-stimulating hormone receptor (TSHR) defect.
http://purl.obolibrary.org/obo/HP_0011795	Intralobar nephroblastomatosis	http://purl.obolibrary.org/obo/HP_0008643	Nephroblastomatosis		Presence of persistent islands of renal blastema in the postnatal kidney, anywhere within a renal lobe (a portion of a kidney consisting of a renal pyramid and the renal cortex above it).
http://purl.obolibrary.org/obo/HP_0011796	Perilobar nephroblastomatosis	http://purl.obolibrary.org/obo/HP_0008643	Nephroblastomatosis		Abnormally persistent foci of embryonal immature blastema located in the superficial cortical region (perilobar).
http://purl.obolibrary.org/obo/HP_0011797	Papillary renal cell carcinoma type 1	http://purl.obolibrary.org/obo/HP_0006766	Papillary renal cell carcinoma		A type of papillary renal cell carcinoma that is characterized by small cuboidal cells covering thin papillae with a single line of uniform nuclei and small nucleoli.
http://purl.obolibrary.org/obo/HP_0011798	Renal oncocytoma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.
http://purl.obolibrary.org/obo/HP_0011800	Midface retrusion	http://purl.obolibrary.org/obo/HP_0000309	Abnormal midface morphology		Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle.
http://purl.obolibrary.org/obo/HP_0011801	Enlargement of parotid gland	http://purl.obolibrary.org/obo/HP_0000197	Abnormal parotid gland morphology		Increased size of the parotid gland.
http://purl.obolibrary.org/obo/HP_0011802	Hamartoma of tongue	http://purl.obolibrary.org/obo/HP_0100648	Neoplasm of the tongue		A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the tongue.
http://purl.obolibrary.org/obo/HP_0011803	Bifid nose	http://purl.obolibrary.org/obo/HP_0004122	Midline defect of the nose		Visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip.
http://purl.obolibrary.org/obo/HP_0011807	Type 1 muscle fiber atrophy	http://purl.obolibrary.org/obo/HP_0100295	Muscle fiber atrophy		Atrophy (wasting) affecting primary type 1 muscle fibers. This feature in general can only be observed on muscle biopsy.
http://purl.obolibrary.org/obo/HP_0011808	Decreased patellar reflex	http://purl.obolibrary.org/obo/HP_0002600	Hyporeflexia of lower limbs		Decreased intensity of the patellar reflex (also known as the knee jerk reflex).
http://purl.obolibrary.org/obo/HP_0011809	Paradoxical myotonia	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		A type of myotonia that worsens with repeated muscle contractions.
http://purl.obolibrary.org/obo/HP_0011810	Impaired two-point discrimination	http://purl.obolibrary.org/obo/HP_0011730	Abnormal central sensory function		A reduced ability to distinguish tactile sensations at points that are very close to one another. This can be tested by using special calipers whose points can be set from 2mm to several centimeters apart.
http://purl.obolibrary.org/obo/HP_0011811	Impaired touch localization	http://purl.obolibrary.org/obo/HP_0011730	Abnormal central sensory function		A reduced ability to identify precisely the site of a touch. This test is usually carried out by asking a patient, whose eyes are closed or covered, to touch the same site with a fingertip.
http://purl.obolibrary.org/obo/HP_0011812	Agraphesthesia	http://purl.obolibrary.org/obo/HP_0011730	Abnormal central sensory function		Impaired ability to recognize letters or numbers drawn by an examiner's fingertip on the patient's skin (the patients eyes are closed or covered throughout this examination).
http://purl.obolibrary.org/obo/HP_0011814	Increased urinary hypoxanthine level	http://purl.obolibrary.org/obo/HP_0040425	Abnormal urinary hypoxanthine level		The concentration of hypoxanthine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0011816	Parietal encephalocele	http://purl.obolibrary.org/obo/HP_0002084	Encephalocele		An encephalocele located between bregma and lambda.
http://purl.obolibrary.org/obo/HP_0011817	Basal encephalocele	http://purl.obolibrary.org/obo/HP_0002084	Encephalocele		Basal encephalocele is an encephalocele that occurs along the cribriform plate or through the sphenoid bone. The mass may appear in the nasal cavity, nasopharynx, epipharynx, sphenoid sinus, posterior orbit, or pterygopalatine fossa. The important distinction from other types is that no external tumor is visible except in those rare instances of herniations so large that they protrude through the mouth or nares.
http://purl.obolibrary.org/obo/HP_0011819	Submucous cleft soft palate	http://purl.obolibrary.org/obo/HP_0000185	Cleft soft palate		A cleft of the muscular (soft) portion of the palate that is covered by mucous membrane. Soft-palate submucous clefts are characterized by a midline deficiency or lack of muscle tissue.
http://purl.obolibrary.org/obo/HP_0011820	Membranous choanal atresia	http://purl.obolibrary.org/obo/HP_0000453	Choanal atresia		Absence of the normal opening of the choana (the posterior nasal aperture) as a result of an obstructing choanal membrane that may be thin and strandlike or thick and pluglike.
http://purl.obolibrary.org/obo/HP_0011822	Broad chin	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		Increased width of the midpoint of the mandible (mental protuberance) and overlying soft tissue.
http://purl.obolibrary.org/obo/HP_0011823	Chin with horizontal crease	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		Horizontal crease or fold situated below the vermilion border of the lower lip and above the fatty pad of the chin, with the face at rest.
http://purl.obolibrary.org/obo/HP_0011824	Chin with H-shaped crease	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		H-shaped crease in the fat pad of the chin.
http://purl.obolibrary.org/obo/HP_0011825	Tented philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Prominence of a triangular soft tissue area of the philtrum with the apex to the columella.
http://purl.obolibrary.org/obo/HP_0011826	Philtrum with midline raphe	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Narrow ridge in the midline of the philtral groove.
http://purl.obolibrary.org/obo/HP_0011827	Malaligned philtral ridges	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Absence of the usual parallel position of philtral ridges.
http://purl.obolibrary.org/obo/HP_0011828	Midline sinus of philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Pit in the midline of the philtral groove.
http://purl.obolibrary.org/obo/HP_0011829	Narrow philtrum	http://purl.obolibrary.org/obo/HP_0000288	Abnormality of the philtrum		Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations below the mean. Alternatively, an apparently decreased distance between the ridges of the philtrum.
http://purl.obolibrary.org/obo/HP_0011831	Deviated nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		Nasal tip positioned to one side of the midline.
http://purl.obolibrary.org/obo/HP_0011832	Narrow nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		Decrease in width of the nasal tip.
http://purl.obolibrary.org/obo/HP_0011833	Overhanging nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		Positioning of the nasal tip inferior to the nasal base.
http://purl.obolibrary.org/obo/HP_0011834	Moyamoya phenomenon	http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology		A noninflammatory, progressive occlusion of the intracranial carotid arteries owing to the formation of netlike collateral arteries arising from the circle of Willis.
http://purl.obolibrary.org/obo/HP_0011835	Absent scaphoid	http://purl.obolibrary.org/obo/HP_0004231	Carpal bone aplasia		Congenital absence of the scaphoid..
http://purl.obolibrary.org/obo/HP_0011836	Delayed talus ossification	http://purl.obolibrary.org/obo/HP_0008369	Abnormal tarsal ossification		Delayed maturation and calcification of the talus.
http://purl.obolibrary.org/obo/HP_0011838	Sclerodactyly	http://purl.obolibrary.org/obo/HP_0001072	Thickened skin		Localized thickening and tightness of the skin of the fingers or toes.
http://purl.obolibrary.org/obo/HP_0011841	Ventricular flutter	http://purl.obolibrary.org/obo/HP_0031676	Monomorphic ventricular tachycardia		A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance.
http://purl.obolibrary.org/obo/HP_0011845	Short second metatarsal	http://purl.obolibrary.org/obo/HP_0010743	Short metatarsal		Short (hypoplastic) second metatarsal bone.
http://purl.obolibrary.org/obo/HP_0011846	Osteoblastoma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue.
http://purl.obolibrary.org/obo/HP_0011847	Giant cell tumor of bone	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts.
http://purl.obolibrary.org/obo/HP_0011848	Abdominal colic	http://purl.obolibrary.org/obo/HP_0002027	Abdominal pain		A type of abdominal pain that comes and goes in waves, most often starting and ending suddenly and being of severe intensity.
http://purl.obolibrary.org/obo/HP_0011850	Parotitis	http://purl.obolibrary.org/obo/HP_0000197	Abnormal parotid gland morphology		Inflammation of the parotid gland.
http://purl.obolibrary.org/obo/HP_0011851	Hemopericardium	http://purl.obolibrary.org/obo/HP_0001698	Pericardial effusion		Accumulation of blood within the pericardial sac.
http://purl.obolibrary.org/obo/HP_0011852	Chylopericardium	http://purl.obolibrary.org/obo/HP_0001698	Pericardial effusion		Accumulation of chyle (the whitish fluid taken up by the lacteals in the intestine, consisting of an emulsion of lymph and triglyceride fat thatpasses into the veins by the thoracic duct) in the pericardium. Chylopericardium is generally caused by obstruction of or trauma to the thoracic duct.
http://purl.obolibrary.org/obo/HP_0011853	Serous pericardial effusion	http://purl.obolibrary.org/obo/HP_0001698	Pericardial effusion		Accumulation of serous fluid (pale yellow and transparent fluid) in the pericardial sac.
http://purl.obolibrary.org/obo/HP_0011854	Hemoperitoneum	http://purl.obolibrary.org/obo/HP_0002585	Abnormal peritoneum morphology		Accumulation of blood in the peritoneal cavity owing to internal hemorrhage.
http://purl.obolibrary.org/obo/HP_0011855	Pharyngeal edema	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		Abnormal accumulation of fluid leading to swelling of the pharynx.
http://purl.obolibrary.org/obo/HP_0011856	Pica	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month.
http://purl.obolibrary.org/obo/HP_0011857	Plasmacytoma	http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm		A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location.
http://purl.obolibrary.org/obo/HP_0011858	Reduced factor IX activity	http://purl.obolibrary.org/obo/HP_0033062	Abnormal factor IX activity		Decreased activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.
http://purl.obolibrary.org/obo/HP_0011859	Punctate keratitis	http://purl.obolibrary.org/obo/HP_0000491	Keratitis		A type of keratitis characterized by inflammation in pinpoint areas of the corneal epithelium.
http://purl.obolibrary.org/obo/HP_0011860	Metaphyseal dappling	http://purl.obolibrary.org/obo/HP_0004979	Metaphyseal sclerosis		The presence of spots or rounded patches of abnormally increased density of metaphyseal bone.
http://purl.obolibrary.org/obo/HP_0011861	Bilateral trilobed lung	http://purl.obolibrary.org/obo/HP_0002101	Abnormal lung lobation		Both lungs have three lobes. Normally, the left lung has two lobes, whereas the right lung has three lobes.
http://purl.obolibrary.org/obo/HP_0011863	Abnormal sternal ossification	http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification		Any anomaly in the formation of the bony substance of the sternum.
http://purl.obolibrary.org/obo/HP_0011864	Elevated plasma pyrophosphate	http://purl.obolibrary.org/obo/HP_0100529	Abnormal circulating phosphate ion concentration		An abnormally increased diphosphate(4-) concentration in the blood. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate.
http://purl.obolibrary.org/obo/HP_0011868	Sciatica	http://purl.obolibrary.org/obo/HP_0003418	Back pain		Pain in the lower back and hip radiating in the distribution of the sciatic nerve.
http://purl.obolibrary.org/obo/HP_0011870	Impaired arachidonic acid-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to arachidonic acid as manifested by reduced or lacking aggregation of platelets upon addition of arachidonic acid.
http://purl.obolibrary.org/obo/HP_0011871	Impaired ristocetin-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin.
http://purl.obolibrary.org/obo/HP_0011872	Impaired thrombin-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to thrombin or thrombin mimetics as manifested by reduced or lacking aggregation of platelets upon addition of thrombin (or thrombin mimetics).
http://purl.obolibrary.org/obo/HP_0011874	Heparin-induced thrombocytopenia	http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia		Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin.
http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology	http://purl.obolibrary.org/obo/HP_0001872	Abnormality of thrombocytes		An anomaly in platelet form, ultrastructure, or intracellular organelles.
http://purl.obolibrary.org/obo/HP_0011876	Abnormal platelet volume	http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology		Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers.
http://purl.obolibrary.org/obo/HP_0011879	Decreased platelet glycoprotein Ib-IX-V	http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression		Decreased cell membrane concentration of the glycoprotein complex Ib-IX-V.
http://purl.obolibrary.org/obo/HP_0011880	Acute disseminated intravascular coagulation	http://purl.obolibrary.org/obo/HP_0005521	Disseminated intravascular coagulation		An acute form of disseminated intravascular coagulation. Acute DIC can occur following sudden exposure of blood to procoagulants, with the compensatory hemostatic mechanisms becoming overwhelmed.
http://purl.obolibrary.org/obo/HP_0011881	Decreased platelet glycoprotein VI	http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression		Decreased cell membrane concentration of glycoprotein VI.
http://purl.obolibrary.org/obo/HP_0011882	Decreased platelet P2Y12 receptor	http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression		Decreased cell membrane concentration of P2Y12 receptor.
http://purl.obolibrary.org/obo/HP_0011883	Abnormal platelet granules	http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology		An anomaly of alpha or dense granules or platelet lysosomes.
http://purl.obolibrary.org/obo/HP_0011884	Abnormal umbilical stump bleeding	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Abnormal bleeding of the umbilical stump following separation of the cord at approximately 7-10 days after birth.
http://purl.obolibrary.org/obo/HP_0011886	Hyphema	http://purl.obolibrary.org/obo/HP_0011885	Hemorrhage of the eye		Bleeding in the anterior chamber of the eye.
http://purl.obolibrary.org/obo/HP_0011887	Choroid hemorrhage	http://purl.obolibrary.org/obo/HP_0011885	Hemorrhage of the eye		Hemorrhage from the vessels of the choroid.
http://purl.obolibrary.org/obo/HP_0011888	Bleeding requiring red cell transfusion	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4).
http://purl.obolibrary.org/obo/HP_0011889	Bleeding with minor or no trauma	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Significant bleeding or hemorrhage without significant precipitating factor.
http://purl.obolibrary.org/obo/HP_0011890	Prolonged bleeding following procedure	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Prolonged or protracted bleeding following an invasive procedure or intervention.
http://purl.obolibrary.org/obo/HP_0011891	Post-partum hemorrhage	http://purl.obolibrary.org/obo/HP_0011890	Prolonged bleeding following procedure		Significant maternal hemorrhage/blood loss following deilvery of a child.
http://purl.obolibrary.org/obo/HP_0011892	Decreased circulating vitamin K concentration	http://purl.obolibrary.org/obo/HP_0100831	Abnormal circulating vitamin K concentration		The concentration of vitamin K in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0011894	Impaired thromboxane A2 agonist-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to thromboxane as manifested by reduced or lacking aggregation of platelets upon addition of thromboxane A2 receptor agonists.
http://purl.obolibrary.org/obo/HP_0011896	Subconjunctival hemorrhage	http://purl.obolibrary.org/obo/HP_0011885	Hemorrhage of the eye		Bleeding beneath the mucous membrane that lines the inner surface of the eyelid.
http://purl.obolibrary.org/obo/HP_0011897	Increased total neutrophil count	http://purl.obolibrary.org/obo/HP_0011991	Abnormal total neutrophil count		Abnormal increase of absolute number of neutrophils in the blood, per microliter, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0011898	Abnormality of circulating fibrinogen	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		An abnormality of the level of activity of circulating fibrinogen.
http://purl.obolibrary.org/obo/HP_0011899	Hyperfibrinogenemia	http://purl.obolibrary.org/obo/HP_0011898	Abnormality of circulating fibrinogen		Increased concentration of fibrinogen in the blood.
http://purl.obolibrary.org/obo/HP_0011900	Hypofibrinogenemia	http://purl.obolibrary.org/obo/HP_0011898	Abnormality of circulating fibrinogen		Decreased concentration of fibrinogen in the blood.
http://purl.obolibrary.org/obo/HP_0011901	Dysfibrinogenemia	http://purl.obolibrary.org/obo/HP_0011898	Abnormality of circulating fibrinogen		Qualitatively abnormal fibrinogen.
http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.
http://purl.obolibrary.org/obo/HP_0011903	HbH hemoglobin	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia.
http://purl.obolibrary.org/obo/HP_0011904	Persistence of hemoglobin F	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.
http://purl.obolibrary.org/obo/HP_0011905	Reduced hemoglobin A	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia.
http://purl.obolibrary.org/obo/HP_0011906	Reduced beta/alpha synthesis ratio	http://purl.obolibrary.org/obo/HP_0005560	Imbalanced hemoglobin synthesis		A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia.
http://purl.obolibrary.org/obo/HP_0011907	Reduced alpha/beta synthesis ratio	http://purl.obolibrary.org/obo/HP_0005560	Imbalanced hemoglobin synthesis		A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia.
http://purl.obolibrary.org/obo/HP_0011908	Unilateral radial aplasia	http://purl.obolibrary.org/obo/HP_0003974	Absent radius		Missing radius bone on one side only associated with congenital failure of development.
http://purl.obolibrary.org/obo/HP_0011909	Flattened metacarpal heads	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Abnormally flat shape of the heads of the metacarpal bones.
http://purl.obolibrary.org/obo/HP_0011910	Shortening of all phalanges of fingers	http://purl.obolibrary.org/obo/HP_0009803	Short phalanx of finger		Abnormal reduction in length affecting all phalanges.
http://purl.obolibrary.org/obo/HP_0011911	Abnormal metacarpophalangeal joint morphology	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		An anomaly of a metacarpophalangeal joint.
http://purl.obolibrary.org/obo/HP_0011913	Lumbar hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		Excessive, increased hair growth located in the lumbar region.
http://purl.obolibrary.org/obo/HP_0011914	Thoracic hypertrichosis	http://purl.obolibrary.org/obo/HP_0000998	Hypertrichosis		Excessive, increased hair growth located in the thoracic region.
http://purl.obolibrary.org/obo/HP_0011915	Cardiovascular calcification	http://purl.obolibrary.org/obo/HP_0030680	Abnormal cardiovascular system morphology		Abnormal calcification in the cardiovascular system.
http://purl.obolibrary.org/obo/HP_0011916	Toe extensor amyotrophy	http://purl.obolibrary.org/obo/HP_0001436	Abnormality of the foot musculature		Atrophy of the extensor digitorum longus muscles, which mediate extension of the toes.
http://purl.obolibrary.org/obo/HP_0011917	Short 5th toe	http://purl.obolibrary.org/obo/HP_0001831	Short toe		Underdevelopment (hypoplasia) of the fifth toe.
http://purl.obolibrary.org/obo/HP_0011918	Clinodactyly of the 4th toe	http://purl.obolibrary.org/obo/HP_0010338	Deviation of the 4th toe		Bending or curvature of a fourth toe in the tibial direction (i.e., towards the big toe).
http://purl.obolibrary.org/obo/HP_0011919	Pleural empyema	http://purl.obolibrary.org/obo/HP_0002202	Pleural effusion		Accumulation of pus in the pleural cavity.
http://purl.obolibrary.org/obo/HP_0011920	Transudative pleural effusion	http://purl.obolibrary.org/obo/HP_0002202	Pleural effusion		A type of pleural effusion with a transudate (extravascular fluid with low protein content and a low specific gravity). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH.
http://purl.obolibrary.org/obo/HP_0011921	Exudative pleural effusion	http://purl.obolibrary.org/obo/HP_0002202	Pleural effusion		A type of pleural effusion with a exudate (extravascular fluid that has exuded out of a tissue or its capillaries due to injury or inflammation). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH.
http://purl.obolibrary.org/obo/HP_0011922	Abnormal activity of mitochondrial respiratory chain	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		An increased or decreased activity of the mitochondrial respiratory chain.
http://purl.obolibrary.org/obo/HP_0011923	Decreased activity of mitochondrial complex I	http://purl.obolibrary.org/obo/HP_0008972	Decreased activity of mitochondrial respiratory chain		A reduction in the activity of the mitochondrial respiratory chain complex I, which is part of the electron transport chain in mitochondria.
http://purl.obolibrary.org/obo/HP_0011924	Decreased activity of mitochondrial complex III	http://purl.obolibrary.org/obo/HP_0008972	Decreased activity of mitochondrial respiratory chain		A reduction in the activity of the mitochondrial respiratory chain complex III, which is part of the electron transport chain in mitochondria.
http://purl.obolibrary.org/obo/HP_0011925	Decreased activity of mitochondrial ATP synthase complex	http://purl.obolibrary.org/obo/HP_0008972	Decreased activity of mitochondrial respiratory chain		A reduction in the activity of the mitochondrial proton-transporting ATP synthase complex, which makes ATP via oxidative phosphorylation, and is sometimes described as Complex V of the electron transport chain.
http://purl.obolibrary.org/obo/HP_0011926	Proximal placement of hallux	http://purl.obolibrary.org/obo/HP_0010051	Deviation of the hallux		Proximal mislocalization of the big toe from its normal position.
http://purl.obolibrary.org/obo/HP_0011928	Short proximal phalanx of toe	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		Developmental hypoplasia (shortening) of proximal phalanx of toe.
http://purl.obolibrary.org/obo/HP_0011929	Hypersegmentation of proximal phalanx of third finger	http://purl.obolibrary.org/obo/HP_0009358	Abnormality of the proximal phalanx of the 3rd finger		Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the third finger.
http://purl.obolibrary.org/obo/HP_0011931	Abnormal cerebellar peduncle morphology	http://purl.obolibrary.org/obo/HP_0012501	Abnormal brainstem white matter morphology		An anomaly of the cerebellar peduncles. The superior, middle, and inferior cerebellar peduncles emerge from the cerebellum. The superior cerebellar penduncles connect the cerebellum to the midbrain, the middle cerebellar peduncles connect the cerebellum to the pons, and the inferior cerebellar peduncle connects the medulla spinalis and medulla oblongata with the cerebellum.
http://purl.obolibrary.org/obo/HP_0011933	Elongated superior cerebellar peduncle	http://purl.obolibrary.org/obo/HP_0011932	Abnormal superior cerebellar peduncle morphology		Increased length of the superior cerebellar peduncle.
http://purl.obolibrary.org/obo/HP_0011934	Dilatation of mesenteric artery	http://purl.obolibrary.org/obo/HP_0020317	Abnormal abdominal aorta branch artery morphology		Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery or superior mesenteric artery .
http://purl.obolibrary.org/obo/HP_0011935	Decreased urinary urate	http://purl.obolibrary.org/obo/HP_0012610	Abnormality of urinary uric acid level		Decreased concentration of urate in the urine.
http://purl.obolibrary.org/obo/HP_0011936	Decreased plasma total carnitine	http://purl.obolibrary.org/obo/HP_0003234	Decreased circulating carnitine concentration		A decreased concentration of total carnitine in the blood.
http://purl.obolibrary.org/obo/HP_0011937	Hypoplastic fifth toenail	http://purl.obolibrary.org/obo/HP_0001800	Hypoplastic toenails		Underdeveloped nails of the fifth toes.
http://purl.obolibrary.org/obo/HP_0011939	3-4 finger cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		A soft tissue continuity in the A/P axis between fingers 3 and 4.
http://purl.obolibrary.org/obo/HP_0011940	Anterior wedging of T12	http://purl.obolibrary.org/obo/HP_0008422	Vertebral wedging		An abnormality of the shape of the thoracic vertebra T12 such that it is wedge-shaped (narrow towards the front).
http://purl.obolibrary.org/obo/HP_0011941	Anterior wedging of L2	http://purl.obolibrary.org/obo/HP_0008422	Vertebral wedging		An abnormality of the shape of the lumbar vertebra L2 such that it is wedge-shaped (narrow towards the front).
http://purl.obolibrary.org/obo/HP_0011942	Increased urinary sulfite level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The concentration of SO3(2-), i.e., sulfite, in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0011943	Increased urinary thiosulfate	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Increased concentration of thiosulfate(2-) in the urine.
http://purl.obolibrary.org/obo/HP_0011944	Small vessel vasculitis	http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site		A type of vasculitis (inflammation of blood vessel walls) that affects blood vessels that are smaller than arteries, i.e., arterioles, venules, and capilllaries.
http://purl.obolibrary.org/obo/HP_0011945	Bronchiolitis obliterans organizing pneumonia	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Bronchiolitis obliterans organizing pneumonia (BOOP) is and interstitial lung abnormalitiy characterized histopathologically by plugs of granulation tissue lying within small airways, alveolar ducts, and alveoli and by chronic inflammatory cell infiltration in alveolar walls. Patients with BOOP generally present with subacute illness, including shortness of breath, fever, malaise, and weight loss.
http://purl.obolibrary.org/obo/HP_0011946	Bronchiolitis obliterans	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Inflammation and fibrosis of the bronchioles leading to partial or complete obstruction of these airways.
http://purl.obolibrary.org/obo/HP_0011948	Recurrent acute respiratory tract infection	http://purl.obolibrary.org/obo/HP_0002205	Recurrent respiratory infections		A history of repeated acute infections of the upper or lower respiratory tract.
http://purl.obolibrary.org/obo/HP_0011949	Acute infectious pneumonia	http://purl.obolibrary.org/obo/HP_0002090	Pneumonia		Acute inflammation of the lung due to an infection.
http://purl.obolibrary.org/obo/HP_0011950	Unusual bronchiolitis	http://purl.obolibrary.org/obo/HP_5210123	Unusual lower respiratory tract infection		Increased susceptibility to bronchiolitis (inflammation of the bronchioles) as manifested by recurrent or severe epsiodes of bronchiolitis.
http://purl.obolibrary.org/obo/HP_0011952	Acute aspiration pneumonia	http://purl.obolibrary.org/obo/HP_0011951	Aspiration pneumonia		An acute episode of pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract.
http://purl.obolibrary.org/obo/HP_0011953	Pulmonary lymphoma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		Lung parenchymal involvement with lymphoma.
http://purl.obolibrary.org/obo/HP_0011954	Nodular regenerative hyperplasia of liver	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Diffuse benign transformation of the hepatic parenchyma into small regenerative nodules with minimal or no fibrosis.
http://purl.obolibrary.org/obo/HP_0011955	Hepatic granulomatosis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		The presence of multiple granulomas in the liver as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes.
http://purl.obolibrary.org/obo/HP_0011956	Intestinal lymphoid nodular hyperplasia	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		A lymphoproliferative abnormality of the intestine characterized by numerous visible mucosal nodules measuring up to, and rarely exceeding, 0.5 cm in diameter Histologically, hyperplastic lymphoid follicles with large germinal centers are seen in the lamina propria and superficial submucosa. There is enlargement of the mucosal B cell follicles caused by hyperplasia of the follicle centers; surrounded by a normal appearing mantle zone. Disease may involve the stomach, the entire small intestine, and the large intestine.
http://purl.obolibrary.org/obo/HP_0011957	Abnormal pectoral muscle morphology	http://purl.obolibrary.org/obo/HP_0009131	Abnormality of the musculature of the thorax		An abnormality of the pectoral muscle, comprising the pectoralis major, a thick, fan-shaped muscle of the anterior chest and the pectoralis minor, a thin, triangular muscle situated underneath the pectoralis major.
http://purl.obolibrary.org/obo/HP_0011958	Retinal perforation	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		A hole through the whole thickness of the retina, associated with trauma.
http://purl.obolibrary.org/obo/HP_0011959	Unilateral hypoplasia of pectoralis major muscle	http://purl.obolibrary.org/obo/HP_0011957	Abnormal pectoral muscle morphology		Hypoplasia (underdevelopment) of the pectoralis minor on only one side of the chest.
http://purl.obolibrary.org/obo/HP_0011960	Substantia nigra gliosis	http://purl.obolibrary.org/obo/HP_0002171	Gliosis		Focal proliferation of glial cells in the substantia nigra.
http://purl.obolibrary.org/obo/HP_0011961	Non-obstructive azoospermia	http://purl.obolibrary.org/obo/HP_0000027	Azoospermia		Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy.
http://purl.obolibrary.org/obo/HP_0011962	Obstructive azoospermia	http://purl.obolibrary.org/obo/HP_0000027	Azoospermia		Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy.
http://purl.obolibrary.org/obo/HP_0011963	Pretesticular azoospermia	http://purl.obolibrary.org/obo/HP_0000027	Azoospermia		Absence of any measurable level of sperm in his semen, due to a hypothalamic or pituitary abnormality diagnosed with hypo-gonadotropic-hypogonadism. The diagnosis is made on the basis of low LH and FSH levels and low or normal testosterone levels.
http://purl.obolibrary.org/obo/HP_0011964	Intermittent painful muscle spasms	http://purl.obolibrary.org/obo/HP_0003394	Muscle spasm		History of repeated intermittent involuntary muscle contractions that were painful.
http://purl.obolibrary.org/obo/HP_0011966	Elevated plasma citrulline	http://purl.obolibrary.org/obo/HP_0011965	Abnormal circulating citrulline concentration		An increased concentration of citrulline in the blood.
http://purl.obolibrary.org/obo/HP_0011967	Decreased circulating copper concentration	http://purl.obolibrary.org/obo/HP_0010836	Abnormal circulating copper concentration		The concentration of copper cation in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0011968	Feeding difficulties	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow it.
http://purl.obolibrary.org/obo/HP_0011969	Elevated circulating luteinizing hormone level	http://purl.obolibrary.org/obo/HP_0000837	Increased circulating gonadotropin level		An elevated concentration of luteinizing hormone in the blood.
http://purl.obolibrary.org/obo/HP_0011970	Cerebral amyloid angiopathy	http://purl.obolibrary.org/obo/HP_0020015	Amyloid deposition by anatomical site		Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system.
http://purl.obolibrary.org/obo/HP_0011971	Dermatographic urticaria	http://purl.obolibrary.org/obo/HP_0410134	Physical urticaria		An exaggerated whealing tendency when the skin is stroked, that is, formation of red, itchy bumps and lines on the skin as a result of pressure on the skin (for instance, stroking the skin with a pen or tongue depressor).
http://purl.obolibrary.org/obo/HP_0011972	Hypoglycorrhachia	http://purl.obolibrary.org/obo/HP_0031884	Abnormal CSF glucose concentration		Abnormally low glucose concentration in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0011973	Paroxysmal lethargy	http://purl.obolibrary.org/obo/HP_0001254	Lethargy		Repeated episodes of sudden-onset and transient lethargy.
http://purl.obolibrary.org/obo/HP_0011974	Myelofibrosis	http://purl.obolibrary.org/obo/HP_0012145	Abnormality of multiple cell lineages in the bone marrow		Replacement of bone marrow by fibrous tissue.
http://purl.obolibrary.org/obo/HP_0011975	Aminoglycoside-induced hearing loss	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		Partial or complete loss of hearing following ingestion of aminoglycoside antibiotics.
http://purl.obolibrary.org/obo/HP_0011977	Elevated urinary homovanillic acid	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An increased concentration of homovanillic acid in the urine.
http://purl.obolibrary.org/obo/HP_0011978	Elevated urinary vanillylmandelic acid	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An increased concentration of vanillylmandelic acid in the urine.
http://purl.obolibrary.org/obo/HP_0011979	Elevated urinary dopamine level	http://purl.obolibrary.org/obo/HP_0011976	Elevated urinary catecholamine level		The concentration of dopamine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0011980	Cholesterol gallstones	http://purl.obolibrary.org/obo/HP_0001081	Cholelithiasis		Gallstones composed primarily of cholesterol, usually about 2-3 cm in length with an oval form and a yellow or green/brown color.
http://purl.obolibrary.org/obo/HP_0011981	Pigment gallstones	http://purl.obolibrary.org/obo/HP_0001081	Cholelithiasis		Gallstones composed primarily of bilirubin and calcium salts (calcium bilirubinate) with a low cholesterol concentration.
http://purl.obolibrary.org/obo/HP_0011982	Black pigment gallstones	http://purl.obolibrary.org/obo/HP_0011981	Pigment gallstones		A type of pigment gallstone that is hard and black, containing calcium carbonate and calcium phosphates.
http://purl.obolibrary.org/obo/HP_0011983	Brown pigment gallstones	http://purl.obolibrary.org/obo/HP_0011981	Pigment gallstones		A type of pigment gallstone that is brown, containing calcium fatty acids. These stones are softer than black pigment gallstones.
http://purl.obolibrary.org/obo/HP_0011984	Atretic gallbladder	http://purl.obolibrary.org/obo/HP_0011466	Aplasia/Hypoplasia of the gallbladder		Failure of formation of the lumen of the gallbladder, often associated with gallbladder hypoplasia.
http://purl.obolibrary.org/obo/HP_0011985	Acholic stools	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Clay colored stools lacking bile pigment.
http://purl.obolibrary.org/obo/HP_0011987	Ectopic ossification in muscle tissue	http://purl.obolibrary.org/obo/HP_0011986	Ectopic ossification		Formation of abnormal bony tissue within muscle tissue.
http://purl.obolibrary.org/obo/HP_0011988	Ectopic ossification in tendon tissue	http://purl.obolibrary.org/obo/HP_0011986	Ectopic ossification		Formation of abnormal bony tissue within tendon tissue.
http://purl.obolibrary.org/obo/HP_0011989	Ectopic ossification in ligament tissue	http://purl.obolibrary.org/obo/HP_0011986	Ectopic ossification		Formation of abnormal bony tissue within ligament tissue.
http://purl.obolibrary.org/obo/HP_0011990	Abnormal neutrophil physiology	http://purl.obolibrary.org/obo/HP_0033796	Abnormal leukocyte physiology		Any functional abnormality of neutrophils.
http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology	http://purl.obolibrary.org/obo/HP_0001874	Abnormality of neutrophils		An abnormal form or size of neutrophils.
http://purl.obolibrary.org/obo/HP_0011995	Atrial septal dilatation	http://purl.obolibrary.org/obo/HP_0011994	Abnormal atrial septum morphology		A bulging of the interatrial septum towards one side. In adults, atrial septal aneurysm can be defined as a protrusion of the aneurysm of >10 mm beyond the plane of the atrial septum as measured by transesophageal echocardiography.
http://purl.obolibrary.org/obo/HP_0011996	Elevated coagulation factor V activity	http://purl.obolibrary.org/obo/HP_0031899	Abnormal coagulation factor V activity		Increased activity of coagulation factor V, Factor V, which is activated to factor Va by means of minute amounts of thrombin (and inactivated by larger amounts of thrombin). Activated factor V (fVa) is a cofactor in the formation of the prothrombinase complex.
http://purl.obolibrary.org/obo/HP_0011997	Postprandial hyperlactemia	http://purl.obolibrary.org/obo/HP_0002151	Increased circulating lactate concentration		Abnormally increased level of blood lactate following a meal.
http://purl.obolibrary.org/obo/HP_0011998	Postprandial hyperglycemia	http://purl.obolibrary.org/obo/HP_0003074	Hyperglycemia		An increased concentration of glucose in the blood following a meal.
http://purl.obolibrary.org/obo/HP_0011999	Paranoia	http://purl.obolibrary.org/obo/HP_5200242	Cognitive distortion		The feeling and belief that one is being targeted or is a focus of negative or untoward actions, overt or covert, from others. The affected individual expresses a concern that people are in general against the individual and are engaging in subtle behaviors to make things difficult for them. The origins of such thinking may arise from real events and become amplified over time. Paranoia may also arise in the absence of any action or interaction between the person and their environment.
http://purl.obolibrary.org/obo/HP_0012000	EEG with generalized spikes	http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges		EEG with generalized sharp transient waves of a duration less than 80 msec.
http://purl.obolibrary.org/obo/HP_0012001	EEG with generalized polyspikes	http://purl.obolibrary.org/obo/HP_0011198	EEG with generalized epileptiform discharges		EEG with repetitive generalized sharp transient waves of a duration less than 80 msec.
http://purl.obolibrary.org/obo/HP_0012002	Experiential epileptic aura	http://purl.obolibrary.org/obo/HP_0033346	Psychic epileptic aura		Affective, mnemonic or composite perceptual auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context.
http://purl.obolibrary.org/obo/HP_0012003	Affective epileptic aura	http://purl.obolibrary.org/obo/HP_0033346	Psychic epileptic aura		Affective auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context.
http://purl.obolibrary.org/obo/HP_0012004	Focal cognitive seizure with deja vu/jamais vu	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0012005	Deja vu aura	http://purl.obolibrary.org/obo/HP_0012004	Focal cognitive seizure with deja vu/jamais vu		A subjective feeling that an experience which is occurring for the first time has been experienced before.
http://purl.obolibrary.org/obo/HP_0012006	Jamais vu aura	http://purl.obolibrary.org/obo/HP_0012004	Focal cognitive seizure with deja vu/jamais vu		A subjective feeling that an experience which has occurred before is being experienced for the first time.
http://purl.obolibrary.org/obo/HP_0012007	Focal cognitive seizure with hallucination	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by hallucination as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0012008	Focal cognitive seizure with illusion	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by an alteration of actual perception involving visual, auditory, somatosensory, olfactory, and/or gustatory phenomena as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0012009	EEG with central focal spike waves	http://purl.obolibrary.org/obo/HP_0033718	EEG with central epileptiform discharges		EEG with focal sharp transient waves in the central region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0012010	EEG with frontal focal spike waves	http://purl.obolibrary.org/obo/HP_0033716	EEG with frontal epileptiform discharges		EEG with focal sharp transient waves in the frontal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0012011	EEG with occipital focal spike waves	http://purl.obolibrary.org/obo/HP_0033720	EEG with occipital epileptiform discharges		EEG with focal sharp transient waves in the occipital region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0012012	EEG with parietal focal spike waves	http://purl.obolibrary.org/obo/HP_0033719	EEG with parietal epileptiform discharges		EEG with focal sharp transient waves in the parietal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0012013	EEG with temporal focal spike waves	http://purl.obolibrary.org/obo/HP_0033717	EEG with temporal epileptiform discharges		EEG with focal sharp transient waves in the temporal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0012014	EEG with central focal spikes	http://purl.obolibrary.org/obo/HP_0033718	EEG with central epileptiform discharges		EEG with focal sharp transient waves of a duration less than 80 msec in the central region.
http://purl.obolibrary.org/obo/HP_0012015	EEG with frontal focal spikes	http://purl.obolibrary.org/obo/HP_0033716	EEG with frontal epileptiform discharges		EEG with focal sharp transient waves of a duration less than 80 msec in the frontal region.
http://purl.obolibrary.org/obo/HP_0012016	EEG with occipital focal spikes	http://purl.obolibrary.org/obo/HP_0033720	EEG with occipital epileptiform discharges		EEG with focal sharp transient waves of a duration less than 80 msec in the occipital region.
http://purl.obolibrary.org/obo/HP_0012017	EEG with parietal focal spikes	http://purl.obolibrary.org/obo/HP_0033719	EEG with parietal epileptiform discharges		EEG with focal sharp transient waves of a duration less than 80 msec in the parietal region.
http://purl.obolibrary.org/obo/HP_0012018	EEG with temporal focal spikes	http://purl.obolibrary.org/obo/HP_0033717	EEG with temporal epileptiform discharges		EEG with focal sharp transient waves of a duration less than 80 msec in the temporal region.
http://purl.obolibrary.org/obo/HP_0012019	Lens luxation	http://purl.obolibrary.org/obo/HP_0001083	Ectopia lentis		Complete dislocation of the lens of the eye.
http://purl.obolibrary.org/obo/HP_0012021	Persistent patent ductus venosus	http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology		Persistence of blood flow through the ductus venosus for longer than the normal time after birth.
http://purl.obolibrary.org/obo/HP_0012022	Congenital portosystemic venous shunt	http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology		A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver).
http://purl.obolibrary.org/obo/HP_0012023	Galactosuria	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		Elevated concentration of galactose in the urine.
http://purl.obolibrary.org/obo/HP_0012024	Hypergalactosemia	http://purl.obolibrary.org/obo/HP_0020347	Abnormal circulating monosaccharide concentration		The concentration of galactose in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0012025	Abnormal circulating ornithine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Deviation from the normal concentration of ornithine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0012026	Hyperornithinemia	http://purl.obolibrary.org/obo/HP_0012025	Abnormal circulating ornithine concentration		Increased concentration of ornithine in the blood.
http://purl.obolibrary.org/obo/HP_0012027	Laryngeal edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		An abnormal accumulation of fluid and swelling in the tissues of the larynx.
http://purl.obolibrary.org/obo/HP_0012028	Hepatocellular adenoma	http://purl.obolibrary.org/obo/HP_0002896	Neoplasm of the liver		A benign tumor of the liver of presumably epithelial origin.
http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The amount of an steroid metabolite in the urine, normalized for urine concentration, is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0012030	Increased urinary cortisol level	http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level		Abnormally increased concentration of cortisol in the urine.
http://purl.obolibrary.org/obo/HP_0012032	Lipoma	http://purl.obolibrary.org/obo/HP_0012031	Lipomatous tumor		Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous.
http://purl.obolibrary.org/obo/HP_0012033	Sacral lipoma	http://purl.obolibrary.org/obo/HP_6000590	Spinal lipoma		Presence of a lipoma in the region of the sacrum.
http://purl.obolibrary.org/obo/HP_0012034	Liposarcoma	http://purl.obolibrary.org/obo/HP_0012031	Lipomatous tumor		Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway.
http://purl.obolibrary.org/obo/HP_0012035	Steatocystoma multiplex	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		Multiple, localized or widespread, asymptomatic or inflammatory dermal cysts involving the pilosebaceous units. Lesions can appear anywhere on the body, but steatocystoma multiplex is more commonly involved with those areas of the skin with a high density of developed pilosebaceous units (e.g., the axilla, groin, neck, and proximal extremities).
http://purl.obolibrary.org/obo/HP_0012036	Sternocleidomastoid amyotrophy	http://purl.obolibrary.org/obo/HP_0003202	Skeletal muscle atrophy		Wasting of the sternocleidomastoid muscle, the muscle in the anterior part of the neck that acts to flex and rotate the head.
http://purl.obolibrary.org/obo/HP_0012037	Pectoralis amyotrophy	http://purl.obolibrary.org/obo/HP_0011957	Abnormal pectoral muscle morphology		Wasting of the pectoral muscles, i.e., of the pectoralis major and pectoralis minor. This finding is often manifested by prominent axillary creases or double axillary creases.
http://purl.obolibrary.org/obo/HP_0012038	Corneal guttata	http://purl.obolibrary.org/obo/HP_0011490	Abnormal Descemet membrane morphology		Corneal guttata are droplet-like accumulations of non-banded collagen on the posterior surface of Descemet's membrane. The presence of focal thickenings of Descemet's membrane histologically named guttae. Cornea guttata can be easily diagnosed in vivo and ex vivo by means of specular microscopy as it gives dark areas where no endothelial cells are visible.
http://purl.obolibrary.org/obo/HP_0012039	Descemet Membrane Folds	http://purl.obolibrary.org/obo/HP_0011490	Abnormal Descemet membrane morphology		Presence of folds in the Descemet membrane, which is the basement membrane of the endothelial (inner) cell layer of the cornea. Descemet membrane folds are generally a manifestation of inflammation or edema of the cornea.
http://purl.obolibrary.org/obo/HP_0012040	Corneal stromal edema	http://purl.obolibrary.org/obo/HP_0011492	Abnormal corneal stroma morphology		Abnormal accumulation of fluid and swelling of the stroma of cornea.
http://purl.obolibrary.org/obo/HP_0012042	Aspirin-induced asthma	http://purl.obolibrary.org/obo/HP_0002099	Asthma		A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction.
http://purl.obolibrary.org/obo/HP_0012043	Pendular nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		Rhythmic, involuntary sinusoidal oscillations of one or both eyes. The waveform of pendular nystagmus may occur in any direction.
http://purl.obolibrary.org/obo/HP_0012044	Seesaw nystagmus	http://purl.obolibrary.org/obo/HP_0012043	Pendular nystagmus		Seesaw nystagmus is a type of pendular nystagmus where a half cycle consists of the elevation and intorsion of one eye, concurrently with the depression and extortion of the fellow eye. In the other half cycle, there is an inversion of the ocular movements.
http://purl.obolibrary.org/obo/HP_0012045	Retinal flecks	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Presence of multiple yellowish-white lesions of various size and configuration on the retina not related to vascular lesions.
http://purl.obolibrary.org/obo/HP_0012046	Areflexia of upper limbs	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		Inability to elicit tendon reflexes in the upper limbs.
http://purl.obolibrary.org/obo/HP_0012047	Hemeralopia	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		A visual defect characterized by the inability to see as clearly in bright light as in dim light. The word hemeralopia literally means day blindness.
http://purl.obolibrary.org/obo/HP_0012048	Oromandibular dystonia	http://purl.obolibrary.org/obo/HP_0012179	Craniofacial dystonia		A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech.
http://purl.obolibrary.org/obo/HP_0012049	Laryngeal dystonia	http://purl.obolibrary.org/obo/HP_0001618	Dysphonia		A form of focal dystonia that affects the vocal cords, associated with involuntary contractions of the vocal cords causing interruptions of speech and affecting the voice quality and often leading to patterned, repeated breaks in speech.
http://purl.obolibrary.org/obo/HP_0012050	Anasarca	http://purl.obolibrary.org/obo/HP_0007430	Generalized edema		An extreme form of generalized edema with widespread and massive edema due to effusion of fluid into the extracellular space.
http://purl.obolibrary.org/obo/HP_0012051	Reactive hypoglycemia	http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia		Hypoglycermia following a meal (or more generally, after intake of glucose).
http://purl.obolibrary.org/obo/HP_0012052	Decreased circulating calcitriol concentration	http://purl.obolibrary.org/obo/HP_0100511	Abnormal circulating vitamin D concentration		The concentration of calcitriol in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0012053	Decreased circulating calcifediol concentration	http://purl.obolibrary.org/obo/HP_0100511	Abnormal circulating vitamin D concentration		A reduced concentration of calcifediol in the blood. Calcifediol is also known as calcidiol, 25-hydroxycholecalciferol and 25-Hydroxyvitamin D3.
http://purl.obolibrary.org/obo/HP_0012054	Choroidal melanoma	http://purl.obolibrary.org/obo/HP_0007716	Uveal melanoma		Malignant tumor of melanocytes of the choroid. The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented).
http://purl.obolibrary.org/obo/HP_0012055	Ciliary body melanoma	http://purl.obolibrary.org/obo/HP_0007716	Uveal melanoma		Malignant tumor of melanocytes of the ciliary body.
http://purl.obolibrary.org/obo/HP_0012056	Cutaneous melanoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		The presence of a melanoma of the skin.
http://purl.obolibrary.org/obo/HP_0012057	Superficial spreading melanoma	http://purl.obolibrary.org/obo/HP_0012056	Cutaneous melanoma		A type of melanoma that is flat and irregular in shape and color, with different shades of black and brown.
http://purl.obolibrary.org/obo/HP_0012058	Nodular melanoma	http://purl.obolibrary.org/obo/HP_0012056	Cutaneous melanoma		A type of melanoma that starts as a raised area that is usually dark blackish-blue or bluish-red but may not have any color.
http://purl.obolibrary.org/obo/HP_0012059	Lentigo maligna melanoma	http://purl.obolibrary.org/obo/HP_0012056	Cutaneous melanoma		A subtype of melanoma in situ that typically develops on sun-damaged skin. The lesion is typically a large, irregularly pigmented macule that has developed from an ordinary lentigo (a small pigmented spot on the skin with a clearly-defined edge). Change to a malignant lentigo typically takes place over 20 years or more, and many patients accept the change as a consequence of aging.
http://purl.obolibrary.org/obo/HP_0012060	Acral lentiginous melanoma	http://purl.obolibrary.org/obo/HP_0012056	Cutaneous melanoma		A type of cutaneous melanoma localized to the palm, sole, or beneath the nail (subungual melanoma). Acral lentiginous melanoma starts as a slowly-enlarging flat patch of discolored skin and usually displays a size above 6 mm and often several centimeters or more in diameter upon diagnosis and variable pigmentation with a mixutre of colors including brown, and blue-grey, black and red. The surface of the lesion is initially smooth but later in the course may become thicker and irregular, and may ulcerate or bleed.
http://purl.obolibrary.org/obo/HP_0012061	Urinary excretion of sialylated oligosaccharides	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		Excretion of oligosaccharides conjugated to sialic acid in the urine.
http://purl.obolibrary.org/obo/HP_0012063	Aneurysmal bone cyst	http://purl.obolibrary.org/obo/HP_0012062	Bone cyst		Radiographic features include a dilated, radiolucent lesion typically located eccentrically within the metaphyseal portion of the bone, with fluid levels visible on magnetic resonance imaging.
http://purl.obolibrary.org/obo/HP_0012064	Unicameral bone cyst	http://purl.obolibrary.org/obo/HP_0012062	Bone cyst		A benign fluid filled simple cyst of bone filled with serous fluid.
http://purl.obolibrary.org/obo/HP_0012065	Multiple bony cystic lesions	http://purl.obolibrary.org/obo/HP_0012062	Bone cyst		Presence of multiple cystic changes in multiple areas or multiple bones.
http://purl.obolibrary.org/obo/HP_0012066	Increased urinary disaccharide excretion	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		Increased concentration of disaccharide in the urine.
http://purl.obolibrary.org/obo/HP_0012068	Aspartylglucosaminuria	http://purl.obolibrary.org/obo/HP_0012067	Glycopeptiduria		Excretion of excess amounts of aspartylglucosamine in the urine.
http://purl.obolibrary.org/obo/HP_0012069	Keratan sulfate excretion in urine	http://purl.obolibrary.org/obo/HP_0008155	Mucopolysacchariduria		An increased concentration of keratan sulfate in the urine.
http://purl.obolibrary.org/obo/HP_0012070	Chondroitin sulfate excretion in urine	http://purl.obolibrary.org/obo/HP_0008155	Mucopolysacchariduria		An increased concentration of chondroitin sulfate (CHEBI:37397) in the urine.
http://purl.obolibrary.org/obo/HP_0012071	Abnormal circulating acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0010966	Abnormal circulating fatty acid anion concentration		Any deviation from the normal concentration in the blood circulation of an acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine.
http://purl.obolibrary.org/obo/HP_0012073	Abnormal urinary acylglycine profile	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		An abnormal distribution of N-acylglycines in the urine. There are numerous different N-acylglycines, and this term refers to pathological alterations in their level or distribution.
http://purl.obolibrary.org/obo/HP_0012074	Tonic pupil	http://purl.obolibrary.org/obo/HP_0007686	Abnormal pupillary function		An abnormality of the pupillary light reaction characterized by a marked slowing of the light reaction of usually just one pupil. The pupil tends to be relatively dilated, and there is reduced accommodation.
http://purl.obolibrary.org/obo/HP_0012075	Personality disorder	http://purl.obolibrary.org/obo/HP_0031466	Impairment in personality functioning		A personality disorder is a deeply ingrained pattern of behavior of a specified kind that deviates markedly from the norms of generally accepted behavior. It is typically apparent by the time of adolescence and causes long-term difficulties in personal relationships or functioning in society.
http://purl.obolibrary.org/obo/HP_0012076	Borderline personality disorder	http://purl.obolibrary.org/obo/HP_0012075	Personality disorder		A personality disorder characterized by impulsive behavior and unpredictable, capricious mood. Affected individuals show a tendency to have outbursts of emotion and an inability to control these behavioral explosions. They generally experience an intense fear of abandonment or instability and also struggle with feelings of emptiness.
http://purl.obolibrary.org/obo/HP_0012077	Histrionic personality disorder	http://purl.obolibrary.org/obo/HP_0012075	Personality disorder		A personality disorder characterized by shallow and labile affectivity, self-dramatization, theatricality, exaggerated expression of emotions, suggestibility, egocentricity, self-indulgence, lack of consideration for others, easily hurt feelings, and continuous seeking for appreciation, excitement and attention.
http://purl.obolibrary.org/obo/HP_0012078	Motor conduction block	http://purl.obolibrary.org/obo/HP_0040131	Abnormal motor nerve conduction velocity		Blockade of impulses at a focal site along the course of a motor axon.
http://purl.obolibrary.org/obo/HP_0012079	Abnormality of central motor conduction	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		Any anomaly of the conduction of motor nerve impulses in the central nervous system.
http://purl.obolibrary.org/obo/HP_0012080	Cerebellar granular layer atrophy	http://purl.obolibrary.org/obo/HP_0001272	Cerebellar atrophy		Atrophy of the cerebellum affecting primarily the granular cell layer.
http://purl.obolibrary.org/obo/HP_0012081	Enlarged cerebellum	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		An abnormally increased size of the cerebellum compared to other brain structures.
http://purl.obolibrary.org/obo/HP_0012082	Cerebellar Purkinje layer atrophy	http://purl.obolibrary.org/obo/HP_0001272	Cerebellar atrophy		Atrophy of the cerebellum affecting primarily the Purkinje cell layer.
http://purl.obolibrary.org/obo/HP_0012083	Ubiquitin-positive cerebral inclusion bodies	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		Nuclear or cytoplasmic aggregates that show positive staining with antibodies against ubiquitin within cells of the brain.
http://purl.obolibrary.org/obo/HP_0012085	Pyuria	http://purl.obolibrary.org/obo/HP_0012614	Abnormal urine cytology		The presence of 10 or more white cells per cubic millimeter in a urine specimen, 3 or more white cells per high-power field of unspun urine, a positive result on Gram staining of an unspun urine specimen, or a urinary dipstick test that is positive for leukocyte esterase.
http://purl.obolibrary.org/obo/HP_0012086	Abnormal urinary color	http://purl.obolibrary.org/obo/HP_0033072	Abnormal macroscopic urine appearance		An abnormal color of the urine, that is, the color of the urine appears different from the usual straw-yellow color.
http://purl.obolibrary.org/obo/HP_0012087	Abnormal mitochondrial shape	http://purl.obolibrary.org/obo/HP_0008322	Abnormal mitochondrial morphology		An anomaly in the surface contour of mitochondria.
http://purl.obolibrary.org/obo/HP_0012088	Abnormal urinary odor	http://purl.obolibrary.org/obo/HP_0033072	Abnormal macroscopic urine appearance		A deviation from the normal odor of the urine.
http://purl.obolibrary.org/obo/HP_0012089	Arteritis	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Arterial inflammation.
http://purl.obolibrary.org/obo/HP_0012092	Abnormality of exocrine pancreas physiology	http://purl.obolibrary.org/obo/HP_0012091	Abnormality of pancreas physiology		A functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes.
http://purl.obolibrary.org/obo/HP_0012093	Abnormality of endocrine pancreas physiology	http://purl.obolibrary.org/obo/HP_0012091	Abnormality of pancreas physiology		A function abnormality of the endocrine pancreas.
http://purl.obolibrary.org/obo/HP_0012094	Abnormal pancreas size	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		A deviation from the normal size of the pancreas.
http://purl.obolibrary.org/obo/HP_0012095	Multiple joint dislocation	http://purl.obolibrary.org/obo/HP_0001373	Joint dislocation		Dislocation of many joints.
http://purl.obolibrary.org/obo/HP_0012096	Intracranial epidermoid cyst	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		A congenital inclusion cysts that arises from ectodermal cells that normally form skin cells being left behind in the nervous system during development.
http://purl.obolibrary.org/obo/HP_0012097	Intracranial dermoid cyst	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		A congenital inclusion cysts that arises from the inclusion of ectodermally committed cells at the time of neural tube closure (3rd-5th week of embryogenesis). The capsule of dermoid cysts consists of simple epithelium supported by collagen. In thicker parts, the lining is supplemented with dermis containing hair follicles, sebaceous glands, and apocrine glands.
http://purl.obolibrary.org/obo/HP_0012098	Edema of the dorsum of feet	http://purl.obolibrary.org/obo/HP_0010741	Pedal edema		An abnormal accumulation of fluid beneath the skin on the back of the feet.
http://purl.obolibrary.org/obo/HP_0012101	Decreased serum creatinine	http://purl.obolibrary.org/obo/HP_0012100	Abnormal circulating creatinine concentration		An abnormally reduced amount of creatinine in the blood.
http://purl.obolibrary.org/obo/HP_0012102	Abnormal mitochondrial number	http://purl.obolibrary.org/obo/HP_0008322	Abnormal mitochondrial morphology		A deviation from the normal number of mitochondria per cell.
http://purl.obolibrary.org/obo/HP_0012104	Parietal cortical atrophy	http://purl.obolibrary.org/obo/HP_0002120	Cerebral cortical atrophy		Atrophy of the parietal cortex.
http://purl.obolibrary.org/obo/HP_0012105	Occipital cortical atrophy	http://purl.obolibrary.org/obo/HP_0002120	Cerebral cortical atrophy		Atrophy of the occipital cortex.
http://purl.obolibrary.org/obo/HP_0012106	Rhizomelic leg shortening	http://purl.obolibrary.org/obo/HP_0008905	Rhizomelia		Disproportionate shortening of the proximal segment of the leg (i.e. the femur).
http://purl.obolibrary.org/obo/HP_0012107	Increased fibular diameter	http://purl.obolibrary.org/obo/HP_0005622	Broad long bones		Increased width of the cross sectional diameter of the fibula.
http://purl.obolibrary.org/obo/HP_0012108	Open angle glaucoma	http://purl.obolibrary.org/obo/HP_0000501	Glaucoma		A type of glaucoma defined by an open, normal appearing anterior chamber angle and raised intraocular pressure,
http://purl.obolibrary.org/obo/HP_0012109	Angle closure glaucoma	http://purl.obolibrary.org/obo/HP_0000501	Glaucoma		A type of glaucomatous optic neuropathy in an eye that has evidence of angle closure (i.e. significant iridotrabecular contact).
http://purl.obolibrary.org/obo/HP_0012110	Hypoplasia of the pons	http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology		Underdevelopment of the pons.
http://purl.obolibrary.org/obo/HP_0012111	Abnormality of circulating glucocorticoid level	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An abnormality of the concentration of a glucocorticoid in the blood.
http://purl.obolibrary.org/obo/HP_0012112	Abnormal circulating corticosterone level	http://purl.obolibrary.org/obo/HP_0012111	Abnormality of circulating glucocorticoid level		An abnormality of the concentration of corticosterone in the blood.
http://purl.obolibrary.org/obo/HP_0012113	Abnormal circulating creatine concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		A deviation from the normal concentration of creatine in the blood circulation. Creatine is a derivative of glycine having methyl and amidino groups attached to the nitrogen. Creatine is naturally produced from amino acids, primarily in liver and kidney, and acts as an energy source for cells, primarily for muscle cells.
http://purl.obolibrary.org/obo/HP_0012114	Endometrial carcinoma	http://purl.obolibrary.org/obo/HP_0010784	Uterine neoplasm		A carcinoma of the endometrium, the mucous lining of the uterus.
http://purl.obolibrary.org/obo/HP_0012115	Hepatitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of the liver.
http://purl.obolibrary.org/obo/HP_0012117	Hyperalbuminemia	http://purl.obolibrary.org/obo/HP_0012116	Abnormal circulating albumin concentration		The concentration of albumin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0012118	Laryngeal carcinoma	http://purl.obolibrary.org/obo/HP_0100605	Neoplasm of the larynx		A carcinoma of the larynx.
http://purl.obolibrary.org/obo/HP_0012119	Methemoglobinemia	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Abnormally increased levels of methemoglobin in the blood. In this form of hemoglobin, there is an oxidized ferric iron (Fe +3) rather than the reduced ferrous form (Fe 2+) that is normally found in hemoglobin. Methemoglobin has a reduced affinity for oxygen, resulting in a reduced ability to release oxygen to tissues.
http://purl.obolibrary.org/obo/HP_0012120	Methylmalonic aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		Increased concentration of methylmalonic acid in the urine.
http://purl.obolibrary.org/obo/HP_0012121	Panuveitis	http://purl.obolibrary.org/obo/HP_0000554	Uveitis		Inflammation of the uveal tract in which inflammation affects the anterior chamber, vitreous, retina or choroid.
http://purl.obolibrary.org/obo/HP_0012123	Posterior uveitis	http://purl.obolibrary.org/obo/HP_0000554	Uveitis		Inflammation of the uveal tract in which the primary site of inflammation is the retina or choroid.
http://purl.obolibrary.org/obo/HP_0012124	Intermediate uveitis	http://purl.obolibrary.org/obo/HP_0000554	Uveitis		Inflammation of the uveal tract in which the primary site of inflammation is the vitreous.
http://purl.obolibrary.org/obo/HP_0012125	Prostate cancer	http://purl.obolibrary.org/obo/HP_0100787	Prostate neoplasm		A cancer of the prostate.
http://purl.obolibrary.org/obo/HP_0012126	Stomach cancer	http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach		A cancer arising in any part of the stomach.
http://purl.obolibrary.org/obo/HP_0012127	Uraciluria	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		Increased concentration of uracil in the urine.
http://purl.obolibrary.org/obo/HP_0012128	Basal ganglia necrosis	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		Death of cells in the basal ganglia. This finding can be confirmed by autopsy. It can be suspected with hyperintensities within the basal ganglia on FLAIR and T2-sequences on magnetic resonance imaging.
http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes.
http://purl.obolibrary.org/obo/HP_0012131	Abnormal number of erythroid precursors	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0012132	Erythroid hyperplasia	http://purl.obolibrary.org/obo/HP_0012131	Abnormal number of erythroid precursors		Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0012133	Erythroid hypoplasia	http://purl.obolibrary.org/obo/HP_0012131	Abnormal number of erythroid precursors		Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0012135	Abnormal granulocytopoietic cell morphology	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		An anomaly of cells involved in the formation of a granulocytes, that is, of the granulocytopoietic cell.
http://purl.obolibrary.org/obo/HP_0012139	Granulocytic hypoplasia	http://purl.obolibrary.org/obo/HP_0012137	Abnormal number of granulocyte precursors		Decreased number of granulocyte precursors in the bone marrow.
http://purl.obolibrary.org/obo/HP_0012142	Pancreatic squamous cell carcinoma	http://purl.obolibrary.org/obo/HP_0002894	Neoplasm of the pancreas		A subtype of ductal pancreatic carcinoma that is thought to originate from squamous metaplasia of pancreatic ductal epithelium.
http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		Any structural anomaly of megakaryocytes. Mature blood platelets are released from the cytoplasm of megakaryocytes, which are bone-marrow resident cells.
http://purl.obolibrary.org/obo/HP_0012144	Abnormal monocyte morphology	http://purl.obolibrary.org/obo/HP_0010974	Abnormal myeloid leukocyte morphology		Any structural anomaly of a myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor	http://purl.obolibrary.org/obo/HP_0003256	Abnormality of the coagulation cascade		Decreased quantity or activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces.
http://purl.obolibrary.org/obo/HP_0012147	Reduced quantity of Von Willebrand factor	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Decreased quantity of von Willebrand factor.
http://purl.obolibrary.org/obo/HP_0012148	Multiple lineage myelodysplasia	http://purl.obolibrary.org/obo/HP_0002863	Myelodysplasia		Myelodysplasia with dysplastic changes in two or more of the myeloid lineages: erythroid, granulocytic, megakaryocytic.
http://purl.obolibrary.org/obo/HP_0012149	Bilineage myelodysplasia	http://purl.obolibrary.org/obo/HP_0002863	Myelodysplasia		Myelodysplasia with dysplastic changes in two of the myeloid lineages: erythroid, granulocytic, megakaryocytic.
http://purl.obolibrary.org/obo/HP_0012150	Single lineage myelodysplasia	http://purl.obolibrary.org/obo/HP_0002863	Myelodysplasia		Abnormality/dysplasia of a single myeloid cell (erythroid, granulocytic, or megakaryocytic).
http://purl.obolibrary.org/obo/HP_0012151	Hemothorax	http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology		The presence of blood in the pleural space.
http://purl.obolibrary.org/obo/HP_0012152	Foveoschisis	http://purl.obolibrary.org/obo/HP_0000493	Abnormal foveal morphology		Splitting of the retinal layers in the macula and involving the fovea.
http://purl.obolibrary.org/obo/HP_0012153	Hypotriglyceridemia	http://purl.obolibrary.org/obo/HP_0045014	Hypolipidemia		An decrease in the level of triglycerides in the blood.
http://purl.obolibrary.org/obo/HP_0012154	Anhedonia	http://purl.obolibrary.org/obo/HP_0031467	Dysregulated negative emotional state		Decreased ability or inability to experience, feel, or anticipate pleasure from activities, experiences, or stimuli that are typically found pleasurable by the individual. This may involve diminished enjoyment of previously rewarding experiences (e.g., hobbies, social interactions, or sexual activity) or reduced pleasure in response to stimuli processed through the senses (e.g., music, food, or tactile contact). Anhedonia is a disruption in the capacity to derive emotional reward and is not due to primary sensory deficits or medical conditions (e.g., anosmia from viral illness). The phenomenon involves altered affective processing rather than impaired sensory perception.
http://purl.obolibrary.org/obo/HP_0012155	Decreased corneal sensation	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		Reduced ability of the cornea to respond to stimulation.
http://purl.obolibrary.org/obo/HP_0012156	Hemophagocytosis	http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology		Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues.
http://purl.obolibrary.org/obo/HP_0012157	Subcortical cerebral atrophy	http://purl.obolibrary.org/obo/HP_0007369	Atrophy/Degeneration affecting the cerebrum		Atrophy of the cerebral subcortical white and gray matter, termed subcortical atrophy, reflects loss of nerve cells in the basal ganglia or fibers in the deep white matter.
http://purl.obolibrary.org/obo/HP_0012158	Carotid artery dissection	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		A separation (dissection) of the layers of the carotid artery wall.
http://purl.obolibrary.org/obo/HP_0012159	Internal carotid artery dissection	http://purl.obolibrary.org/obo/HP_0012158	Carotid artery dissection		A separation (dissection) of the layers of the internal carotid artery wall.
http://purl.obolibrary.org/obo/HP_0012160	Intracranial internal carotid artery dissection	http://purl.obolibrary.org/obo/HP_0012159	Internal carotid artery dissection		A separation (dissection) of the layers of the intracranial portion of the internal carotid artery wall.
http://purl.obolibrary.org/obo/HP_0012161	External carotid artery dissection	http://purl.obolibrary.org/obo/HP_0012158	Carotid artery dissection		A separation (dissection) of the layers of the external carotid artery wall.
http://purl.obolibrary.org/obo/HP_0012162	Common carotid artery dissection	http://purl.obolibrary.org/obo/HP_0012158	Carotid artery dissection		A separation (dissection) of the layers of the common carotid artery wall.
http://purl.obolibrary.org/obo/HP_0012163	Carotid artery dilatation	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		A dilatation (balooning or bulging out of the vessel wall) of a carotid artery.
http://purl.obolibrary.org/obo/HP_0012164	Asterixis	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		A clinical sign indicating a lapse of posture and is usually manifest by a bilateral flapping tremor at the wrist, metacarpophalangeal, and hip joints.
http://purl.obolibrary.org/obo/HP_0012166	Skin-picking	http://purl.obolibrary.org/obo/HP_0100716	Self-injurious behavior		Repetitive and compulsive picking of skin which results in tissue damage.
http://purl.obolibrary.org/obo/HP_0012167	Hair-pulling	http://purl.obolibrary.org/obo/HP_0100716	Self-injurious behavior		A phenomenon in which persons repetitively pull out their own hair, resulting in noticeable hair loss.
http://purl.obolibrary.org/obo/HP_0012168	Head-banging	http://purl.obolibrary.org/obo/HP_5200017	Stereotypic movements of face and head		Habitual striking of one's own head against a surface such as a mattress or wall of a crib.
http://purl.obolibrary.org/obo/HP_0012169	Self-biting	http://purl.obolibrary.org/obo/HP_0100716	Self-injurious behavior		Habitual biting of one's own body.
http://purl.obolibrary.org/obo/HP_0012170	Nail-biting	http://purl.obolibrary.org/obo/HP_0012169	Self-biting		Habitual biting of one's own fingernails.
http://purl.obolibrary.org/obo/HP_0012171	Stereotypical hand wringing	http://purl.obolibrary.org/obo/HP_5200009	Midline hand movements		Habitual clasping and wringing of the hands in the middle of the body, similar to a hand-washing movement.
http://purl.obolibrary.org/obo/HP_0012172	Stereotypical body rocking	http://purl.obolibrary.org/obo/HP_5200019	Stereotypic whole-body movements		Habitual repetitive movement of the entire body, front to back or side to side.
http://purl.obolibrary.org/obo/HP_0012173	Orthostatic tachycardia	http://purl.obolibrary.org/obo/HP_0012332	Abnormal autonomic nervous system physiology		An increase in heart rate with standing of 30 beats per minute or more.
http://purl.obolibrary.org/obo/HP_0012174	Glioblastoma multiforme	http://purl.obolibrary.org/obo/HP_0009733	Glioma		A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation.
http://purl.obolibrary.org/obo/HP_0012175	Resistance to activated protein C	http://purl.obolibrary.org/obo/HP_0030780	Abnormality of the protein C anticoagulant pathway		Poor anticoagulant response to activated protein C. A plasma is termed 'APC resistant' when the addition of exogenous APC fails to prolong its clotting time in an activated partial thromboplastin time assay.
http://purl.obolibrary.org/obo/HP_0012176	Abnormal natural killer cell morphology	http://purl.obolibrary.org/obo/HP_0004332	Abnormal lymphocyte morphology		An anomaly of the natural killer cell, which is a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors. It also regulates immune responses via cytokine release and direct contact with other cells.
http://purl.obolibrary.org/obo/HP_0012177	Abnormal natural killer cell physiology	http://purl.obolibrary.org/obo/HP_0031409	Abnormal lymphocyte physiology		Abnormal response of natural killer (NK) cells to stimuli.
http://purl.obolibrary.org/obo/HP_0012180	Cystic medial necrosis	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells.
http://purl.obolibrary.org/obo/HP_0012181	Entrapment neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		Malfunction of a peripheral nerve resulting from mechanical compression of the nerve roots from internal or external causes and leading to a conduction block or axonal loss.
http://purl.obolibrary.org/obo/HP_0012182	Oropharyngeal squamous cell carcinoma	http://purl.obolibrary.org/obo/HP_0002860	Squamous cell carcinoma		A squamous cell carcinoma that originates in the oropharnyx.
http://purl.obolibrary.org/obo/HP_0012183	Hyperplastic colonic polyposis	http://purl.obolibrary.org/obo/HP_0030255	Large intestinal polyposis		Presence of multiple hyperplastic polyps in the colon. Hyperplastic polyps are generally about 5 mm in size and show hyperplastic mucosal proliferation.
http://purl.obolibrary.org/obo/HP_0012184	Elevated circulating HDL-C concentration	http://purl.obolibrary.org/obo/HP_0031888	Abnormal circulating HDL-C concentration		The concentration of high-density lipoprotein cholesterol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0012185	Constrictive median neuropathy	http://purl.obolibrary.org/obo/HP_0012181	Entrapment neuropathy		Injury to the median nerve caused by its entrapment at the wrist as it traverses through the carpal tunnel. Clinically, constrictive median neuropathy is characterized by pain, paresthesia, and weakness in the median nerve distribution of the hand.
http://purl.obolibrary.org/obo/HP_0012186	Entrapment neuropathy of the ulnar nerve at elbow	http://purl.obolibrary.org/obo/HP_0012181	Entrapment neuropathy		An entrapment neuropathy of the ulnar nerve in the cubital tunnel (in the elbow) characterized by numbness in the ring and little fingers and weakness of the intrinsic muscles in the hand.
http://purl.obolibrary.org/obo/HP_0012187	Increased erythrocyte protoporphyrin concentration	http://purl.obolibrary.org/obo/HP_0034606	Elevated circulating porphyrin concentration		Concentration of protoporphyrins in erythrocytes above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0012188	Hyperemesis gravidarum	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Excessive vomiting in early pregnancy, leading to the loss of 5% or more of body weight.
http://purl.obolibrary.org/obo/HP_0012189	Hodgkin lymphoma	http://purl.obolibrary.org/obo/HP_0002665	Lymphoma		A type of lymphoma characterized microscopically by multinucleated Reed-Sternberg cells.
http://purl.obolibrary.org/obo/HP_0012190	T-cell lymphoma	http://purl.obolibrary.org/obo/HP_0012539	Non-Hodgkin lymphoma		A type of lymphoma that originates in T-cells.
http://purl.obolibrary.org/obo/HP_0012191	B-cell lymphoma	http://purl.obolibrary.org/obo/HP_0012539	Non-Hodgkin lymphoma		A type of lymphoma that originates in B-cells.
http://purl.obolibrary.org/obo/HP_0012192	Cutaneous T-cell lymphoma	http://purl.obolibrary.org/obo/HP_0012190	T-cell lymphoma		A type of T-cell lymphoma that exhibits malignant infiltration of the skin.
http://purl.obolibrary.org/obo/HP_0012193	Anaplastic large-cell lymphoma	http://purl.obolibrary.org/obo/HP_0012190	T-cell lymphoma		A type of T-cell lymphoma that is characterized by so-called hallmark cells with a pleomorphic appearance that express the CD30 antigen, are lobulated, and have indented nuclei.
http://purl.obolibrary.org/obo/HP_0012194	Episodic hemiplegia	http://purl.obolibrary.org/obo/HP_0002301	Hemiplegia		Transient episodes of weakness of the arm, leg, and in some cases the face on one side of the body.
http://purl.obolibrary.org/obo/HP_0012195	Irregular respiration	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Uneven rhythm of breathing.
http://purl.obolibrary.org/obo/HP_0012196	Cheyne-Stokes respiration	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		An abnormal pattern of respiration characterized by cycles of respiration that are increasingly deeper then shallower with possible periods of apnea. Affected patients may display a 10 to 20 second episode of hypoventilation or apnea, followed by respiration of increased depth and frequency over the course of about one minute. The cycle repeats every 45 seconds to 3 minutes.
http://purl.obolibrary.org/obo/HP_0012197	Insulinoma	http://purl.obolibrary.org/obo/HP_0008261	Pancreatic islet cell adenoma		A type of tumor of the pancreatic beta cells that secretes excess insulin and can result in hypoglycemia.
http://purl.obolibrary.org/obo/HP_0012198	Juvenile colonic polyposis	http://purl.obolibrary.org/obo/HP_0004390	Hamartomatous polyposis		The presence of more than 5 juvenile polyps of the colon. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands.
http://purl.obolibrary.org/obo/HP_0012199	Cluster headache	http://purl.obolibrary.org/obo/HP_0002315	Headache		A type of headache characterized by repeated attacks of unilateral pain lasting 15 to 180 minutes and associated with local autonomic signs.
http://purl.obolibrary.org/obo/HP_0012202	Increased serum bile acid concentration	http://purl.obolibrary.org/obo/HP_0030984	Abnormal serum bile acid concentration		An increase in the concentration of bile acid in the blood.
http://purl.obolibrary.org/obo/HP_0012203	Unusual fungal nail infection	http://purl.obolibrary.org/obo/HP_5210238	Unusual nail infection		Increased susceptibility to fungal infection of the nail apparatus (onychomycosis), as manifested by recurrent or severe infection of the nail plate, nail bed, or nail matrix caused by fungal organisms. Causative agents include dermatophytes (Trichophyton species) and Candida species.
http://purl.obolibrary.org/obo/HP_0012204	Recurrent vulvovaginal candidiasis	http://purl.obolibrary.org/obo/HP_0002728	Recurrent mucocutaneous candidiasis		Recurrent infection involving the vulva, vagina, and adjacent crural areas, whereby the causative agent belongs to the genus Candida.
http://purl.obolibrary.org/obo/HP_0012205	Globozoospermia	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Any structural anomaly of the acrosome resulting in a round sperm head.
http://purl.obolibrary.org/obo/HP_0012206	Abnormal sperm motility	http://purl.obolibrary.org/obo/HP_0034809	Abnormal sperm physiology		An anomaly of the mobility of ejaculated sperm.
http://purl.obolibrary.org/obo/HP_0012207	Reduced sperm motility	http://purl.obolibrary.org/obo/HP_0012206	Abnormal sperm motility		An abnormal reduction in the mobility of ejaculated sperm.
http://purl.obolibrary.org/obo/HP_0012208	Immotile sperm	http://purl.obolibrary.org/obo/HP_0012207	Reduced sperm motility		A lack of mobility of ejaculated sperm.
http://purl.obolibrary.org/obo/HP_0012209	Juvenile myelomonocytic leukemia	http://purl.obolibrary.org/obo/HP_0012324	Myeloid leukemia		Juvenile myelomonocytic leukemia (JMML) is a lethal myeloproliferative disease of young childhood characterized clinically by overproduction of myelomonocytic cells and by the in vitro phenotype of hematopoietic progenitor hypersensitivity to granulocyte-macrophage colony-stimulating factor.
http://purl.obolibrary.org/obo/HP_0012212	Abnormal glomerular filtration rate	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		An abnormally increased or reduced amount of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time.
http://purl.obolibrary.org/obo/HP_0012213	Decreased glomerular filtration rate	http://purl.obolibrary.org/obo/HP_0012212	Abnormal glomerular filtration rate		An abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time.
http://purl.obolibrary.org/obo/HP_0012214	Increased glomerular filtration rate	http://purl.obolibrary.org/obo/HP_0012212	Abnormal glomerular filtration rate		An abnormal rise in the volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time.
http://purl.obolibrary.org/obo/HP_0012215	Testicular microlithiasis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		The deposition of calcium phosphate microliths within the seminiferous tubules.
http://purl.obolibrary.org/obo/HP_0012216	Entrapment neuropathy of suprascapular nerve	http://purl.obolibrary.org/obo/HP_0012181	Entrapment neuropathy		An entrapment neuropathy of the suprascapular nerve, presenting with shoulder weakness confined to the supraspinatus muscle (this muscle initiates shoulder abduction) or to the infraspinatus (this muscle externally rotates the arm), as well as with pain in the posterior part of the shoulder and upper periscapular region.
http://purl.obolibrary.org/obo/HP_0012217	Increased urinary porphobilinogen	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of porphobilinogen in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0012218	Alveolar soft part sarcoma	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		A type of soft tissue sarcoma with a histological appearance reminiscent of alveoli because of its reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue.
http://purl.obolibrary.org/obo/HP_0012219	Erythema nodosum	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral.
http://purl.obolibrary.org/obo/HP_0012220	Non-caseating epithelioid cell granulomatosis	http://purl.obolibrary.org/obo/HP_5210340	Non-caseating granulomatosis		The presence of multiple epithelioid cell granulomas consist of highly differentiated mononuclear phagocytes (epithelioid cells and giant cells) and lymphocytes, not exhibiting caseation (a form of necrosis in which the tissue changes into a dry, amorphous mass said to resemble cheese).
http://purl.obolibrary.org/obo/HP_0012221	Pretibial blistering	http://purl.obolibrary.org/obo/HP_0033800	Blistering by anatomical location		A type of blistering that affects the skin of the tibial region.
http://purl.obolibrary.org/obo/HP_0012222	Arachnoid hemangiomatosis	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		The presence of multiple hemangiomas in the arachnoid.
http://purl.obolibrary.org/obo/HP_0012223	Splenic rupture	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		A breach of the capsule of the spleen.
http://purl.obolibrary.org/obo/HP_0012224	Circulating immune complexes	http://purl.obolibrary.org/obo/HP_0005368	Abnormality of humoral immunity		Persistence of immune complexes in the blood circulation.
http://purl.obolibrary.org/obo/HP_0012225	Oligodontia of primary teeth	http://purl.obolibrary.org/obo/HP_0000677	Oligodontia		Reduced number of primary teeth.
http://purl.obolibrary.org/obo/HP_0012226	Ovarian teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		The presence of a teratoma in the ovary.
http://purl.obolibrary.org/obo/HP_0012227	Urethral stricture	http://purl.obolibrary.org/obo/HP_0008661	Urethral stenosis		Narrowing of the urethra associated with inflammation or scar tissue.
http://purl.obolibrary.org/obo/HP_0012228	Tension-type headache	http://purl.obolibrary.org/obo/HP_0002315	Headache		A type of headache that last hours with continuous pain of mild or moderate intensity, bilateral location, a pressing/tightening (non-pulsating) quality and that is not aggravated by routine physical activity such as walking or climbing stairs.
http://purl.obolibrary.org/obo/HP_0012229	CSF pleocytosis	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		An increased white blood cell count in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0012230	Rhegmatogenous retinal detachment	http://purl.obolibrary.org/obo/HP_0000541	Retinal detachment		A type of retinal detachment associated with a full-thickness defect in the retina that allows fluid to pass from the vitreous space into the subretinal space between the sensory retina and the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0012231	Serous retinal detachment	http://purl.obolibrary.org/obo/HP_0000541	Retinal detachment		A type of retinal detachment such that fluid is present in the subretinal space and separate the neurosensory retina from the retinal pigment epithelium. It is not associated with a full-thickness break nor a tractional component. Due to breakdown of outer blood-retina barrier or increased exudation from abnormal vasculature or defective outflow.
http://purl.obolibrary.org/obo/HP_0012232	Shortened QT interval	http://purl.obolibrary.org/obo/HP_0031547	Abnormal QT interval		Decreased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).
http://purl.obolibrary.org/obo/HP_0012233	Intramuscular hematoma	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Blood clot formed within muscle tissue following leakage of blood into the tissue.
http://purl.obolibrary.org/obo/HP_0012234	Absence of circulating granulocytes	http://purl.obolibrary.org/obo/HP_0001913	Decreased total granulocyte count		Absence of detectable circulating granulocytes in the blood. Usually a value of less than 50 cells per microliter is considered to be an absence.
http://purl.obolibrary.org/obo/HP_0012235	Drug-induced agranulocytosis	http://purl.obolibrary.org/obo/HP_0012234	Absence of circulating granulocytes		Absence of detectable circulating granulocytes in the blood caused by an exposure to a drug. Usually a value of less than 50 granulocytes per microliter is considered to be an absence.
http://purl.obolibrary.org/obo/HP_0012236	Elevated sweat chloride	http://purl.obolibrary.org/obo/HP_0040127	Abnormal sweat homeostasis		An increased concentration of chloride in the sweat.
http://purl.obolibrary.org/obo/HP_0012237	Urocanic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An increased concentration of urocanic acid in the urine.
http://purl.obolibrary.org/obo/HP_0012238	Increased circulating chylomicron concentration	http://purl.obolibrary.org/obo/HP_0031887	Abnormal chylomicron concentration		Increased plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins.
http://purl.obolibrary.org/obo/HP_0012239	Atransferrinemia	http://purl.obolibrary.org/obo/HP_0032385	Abnormal circulating transferrin concentration		Absence of transferrin, a protein that transports iron, in the blood.
http://purl.obolibrary.org/obo/HP_0012240	Increased intramyocellular lipid droplets	http://purl.obolibrary.org/obo/HP_0009058	Increased muscle lipid content		An abnormal increase in intracellular lipid droplets In a muscle. The number and size of these drops can increase with somd disorders of lipid metabolism affecting muscle. See PMID 20691590 for histological images.
http://purl.obolibrary.org/obo/HP_0012241	Levator palpebrae superioris atrophy	http://purl.obolibrary.org/obo/HP_3000072	Abnormal levator palpebrae superioris morphology		Atrophy of the levator palpebrae superioris, the extraocular muscle that elevates the superior eyelid.
http://purl.obolibrary.org/obo/HP_0012242	Superior rectus atrophy	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		Atrophy of the superior rectus, the extraocular muscle whose primary function is to elevate the globe.
http://purl.obolibrary.org/obo/HP_0012244	Abnormal sex determination	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		Anomaly of primary or secondary sexual development or characteristics.
http://purl.obolibrary.org/obo/HP_0012245	Sex reversal	http://purl.obolibrary.org/obo/HP_0012244	Abnormal sex determination		Development of the reproductive system is inconsistent with the chromosomal sex.
http://purl.obolibrary.org/obo/HP_0012246	Oculomotor nerve palsy	http://purl.obolibrary.org/obo/HP_0006824	Cranial nerve paralysis		Reduced ability to control the movement of the eye associated with damage to the third cranial nerve (the oculomotor nerve).
http://purl.obolibrary.org/obo/HP_0012247	Specific anosmia	http://purl.obolibrary.org/obo/HP_0000458	Anosmia		Anosmia for one particular odor.
http://purl.obolibrary.org/obo/HP_0012248	Prolonged PR interval	http://purl.obolibrary.org/obo/HP_0031593	Abnormal PR interval		Increased time for the PR interval (beginning of the P wave to the beginning of the QRS complex).
http://purl.obolibrary.org/obo/HP_0012249	Abnormal ST segment	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		An electrocardiographic anomaly of the ST segment, which is the segment that connects the QRS complex and the T wave. The ST segment normally has a duration of 80 to 120 ms, is flat and at the same level (isoelectric) as the PR and TP segment.
http://purl.obolibrary.org/obo/HP_0012250	ST segment depression	http://purl.obolibrary.org/obo/HP_0012249	Abnormal ST segment		An electrocardiographic anomaly in which the ST segment is observed to be located inferior to the isoelectric line.
http://purl.obolibrary.org/obo/HP_0012251	ST segment elevation	http://purl.obolibrary.org/obo/HP_0012249	Abnormal ST segment		An electrocardiographic anomaly in which the ST segment is observed to be located superior to the isoelectric line.
http://purl.obolibrary.org/obo/HP_0012253	Abnormal respiratory epithelium morphology	http://purl.obolibrary.org/obo/HP_0012252	Abnormal respiratory system morphology		Any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.
http://purl.obolibrary.org/obo/HP_0012254	Ewing sarcoma	http://purl.obolibrary.org/obo/HP_0100242	Sarcoma		A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones.
http://purl.obolibrary.org/obo/HP_0012255	Dynein arm defect of respiratory motile cilia	http://purl.obolibrary.org/obo/HP_0005938	Abnormal respiratory motile cilium morphology		An anomaly of the dynein arms of motile cilia. This feature is usually appreciated by electron microscopy.
http://purl.obolibrary.org/obo/HP_0012256	Absent outer dynein arms	http://purl.obolibrary.org/obo/HP_0200106	Absent/shortened dynein arms		Absence of the outer dynein arms of respiratory motile cilia, which normally are situated outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy.
http://purl.obolibrary.org/obo/HP_0012257	Absent inner dynein arms	http://purl.obolibrary.org/obo/HP_0200106	Absent/shortened dynein arms		Absence of the inner dynein arms of respiratory motile cilia, which normally are situated within the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy.
http://purl.obolibrary.org/obo/HP_0012258	Abnormal axonemal organization of respiratory motile cilia	http://purl.obolibrary.org/obo/HP_0005938	Abnormal respiratory motile cilium morphology		Abnormal arrangement of the structures of the axoneme, which is the cytoskeletal structure that forms the inner core of the motile cilium and displays a canonical 9+2 microtubular pattern of motile cilia studded with dynein arms.
http://purl.obolibrary.org/obo/HP_0012259	Absent inner and outer dynein arms	http://purl.obolibrary.org/obo/HP_0012257	Absent inner dynein arms		Complete absence of the dynein arms of respiratory motile cilia, that is, absence of the inner and the outer dynein arms, which normally are situated inside and outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy.
http://purl.obolibrary.org/obo/HP_0012260	Abnormal central microtubular pair morphology of respiratory motile cilia	http://purl.obolibrary.org/obo/HP_0005938	Abnormal respiratory motile cilium morphology		A structural anomaly of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration.
http://purl.obolibrary.org/obo/HP_0012261	Abnormal respiratory motile cilium physiology	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Any functional anomaly of the respiratory motile cilia.
http://purl.obolibrary.org/obo/HP_0012262	Abnormal ciliary motility	http://purl.obolibrary.org/obo/HP_0012261	Abnormal respiratory motile cilium physiology		Any anomaly of the normal motility of motile cilia. Evaluation of ciliary beat frequency and ciliary beat pattern requires high-speed videomicroscopy of freshly obtained ciliary biopsies that are maintained in culture media under controlled conditions.
http://purl.obolibrary.org/obo/HP_0012264	Absent central microtubular pair morphology of respiratory motile cilia	http://purl.obolibrary.org/obo/HP_0005938	Abnormal respiratory motile cilium morphology		Absence of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration.
http://purl.obolibrary.org/obo/HP_0012265	Ciliary dyskinesia	http://purl.obolibrary.org/obo/HP_0012262	Abnormal ciliary motility		A deviation from the normally well coordinated pattern of intracellular and intercellular synchrony of motile cilia. Dyskinetic cilia usually beat out of synchrony relative to neighboring cilia.
http://purl.obolibrary.org/obo/HP_0012266	T-wave alternans	http://purl.obolibrary.org/obo/HP_0005135	Abnormal T-wave		A periodic beat-to-beat variation in the amplitude or shape of the T wave in an EKG.
http://purl.obolibrary.org/obo/HP_0012267	Absent respiratory ciliary axoneme radial spokes	http://purl.obolibrary.org/obo/HP_0005938	Abnormal respiratory motile cilium morphology		Absence of the radial spokes of the axoneme of the respiratory cilium.
http://purl.obolibrary.org/obo/HP_0012268	Myxoid liposarcoma	http://purl.obolibrary.org/obo/HP_0012034	Liposarcoma		A liposarcoma that contains myxomatous tissue.
http://purl.obolibrary.org/obo/HP_0012269	Abnormal muscle glycogen content	http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration		Any anomaly in the amount of glycogen in muscle tissue.
http://purl.obolibrary.org/obo/HP_0012270	Decreased muscle glycogen content	http://purl.obolibrary.org/obo/HP_0012269	Abnormal muscle glycogen content		A decreased amount of glycogen in muscle tissue.
http://purl.obolibrary.org/obo/HP_0012271	Episodic upper airway obstruction	http://purl.obolibrary.org/obo/HP_0002781	Upper airway obstruction		Intermittent episodes of increased resistance to the passage of air in the upper airway.
http://purl.obolibrary.org/obo/HP_0012272	J wave	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		The J wave is a positive convex deflection that occurs at the junction of the QRS complex and ST segment, the J-point.
http://purl.obolibrary.org/obo/HP_0012273	Increased carotid artery intimal medial thickness	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		An increase in the combined thickness of the intima and media of the carotid artery.
http://purl.obolibrary.org/obo/HP_0012274	Autosomal dominant inheritance with paternal imprinting	http://purl.obolibrary.org/obo/HP_0034338	Imprinted		A type of autosomal dominant inheritance involving a gene that is imprinted with paternal silencing.
http://purl.obolibrary.org/obo/HP_0012275	Autosomal dominant inheritance with maternal imprinting	http://purl.obolibrary.org/obo/HP_0034338	Imprinted		A type of autosomal dominant inheritance involving a gene that is imprinted with maternal silencing.
http://purl.obolibrary.org/obo/HP_0012276	Digital flexor tenosynovitis	http://purl.obolibrary.org/obo/HP_6001438	Tenosynovitis		Inflammation of the flexor digitorum tendon, often associated with the Kanavel signs: (i) finger held in slight flexion, (ii) fusiform swelling, (iii) tenderness along the flexor tendon sheath, and (iv) pain with passive extension of the digit.
http://purl.obolibrary.org/obo/HP_0012277	Hypoglycinemia	http://purl.obolibrary.org/obo/HP_0010895	Abnormal circulating glycine concentration		An abnormally reduced concentration of glycine in the blood.
http://purl.obolibrary.org/obo/HP_0012278	Abnormal circulating serine concentration	http://purl.obolibrary.org/obo/HP_0010894	Abnormal circulating serine family amino acid concentration		Any deviation from the normal concentration of serine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0012279	Hyposerinemia	http://purl.obolibrary.org/obo/HP_0012278	Abnormal circulating serine concentration		Reduced concentration of serine in the blood.
http://purl.obolibrary.org/obo/HP_0012280	Hepatic amyloidosis	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		A form of amyloidosis that affects the liver.
http://purl.obolibrary.org/obo/HP_0012281	Chylous ascites	http://purl.obolibrary.org/obo/HP_0001541	Ascites		Extravasation of chyle into the peritoneal cavity.
http://purl.obolibrary.org/obo/HP_0012282	Morbilliform rash	http://purl.obolibrary.org/obo/HP_4000054	Exanthem		An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days.
http://purl.obolibrary.org/obo/HP_0012283	Small distal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0010590	Abnormality of the distal femoral epiphysis		Reduced size of the Distal epiphysis of femur.
http://purl.obolibrary.org/obo/HP_0012284	Small proximal tibial epiphyses	http://purl.obolibrary.org/obo/HP_0010591	Abnormality of the proximal tibial epiphysis		Reduced size of the proximal epiphysis of the tibia.
http://purl.obolibrary.org/obo/HP_0012287	Hypothalamic luteinizing hormone-releasing hormone deficiency	http://purl.obolibrary.org/obo/HP_0012285	Abnormal hypothalamus physiology		Decreased secretion of luteinizing hormone-releasing hormone by the hypothalamus.
http://purl.obolibrary.org/obo/HP_0012288	Neoplasm of head and neck	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx.
http://purl.obolibrary.org/obo/HP_0012289	Facial neoplasm	http://purl.obolibrary.org/obo/HP_0012288	Neoplasm of head and neck		A tumor (abnormal growth of tissue) of the face.
http://purl.obolibrary.org/obo/HP_0012292	Fusion of gums	http://purl.obolibrary.org/obo/HP_0000168	Abnormality of the gingiva		A congenital defect with an abnormal joining of the gums of the upper and lower jaw.
http://purl.obolibrary.org/obo/HP_0012293	Abnormal genital pigmentation	http://purl.obolibrary.org/obo/HP_0000811	Abnormal external genitalia morphology		An abnormal pigmentation pattern of the external genitalia.
http://purl.obolibrary.org/obo/HP_0012294	Abnormal occipital bone morphology	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Abnormality of the occipital bone of the skull.
http://purl.obolibrary.org/obo/HP_0012295	Slender middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		Reduced diameter of the middle phalanx of finger.
http://purl.obolibrary.org/obo/HP_0012296	Slender distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009832	Abnormal distal phalanx morphology of finger		Reduced diameter of the distal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0012297	Slender proximal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		Reduced diameter of the proximal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0012298	Long middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		Increased length of the middle phalanx of finger.
http://purl.obolibrary.org/obo/HP_0012299	Long distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009832	Abnormal distal phalanx morphology of finger		Increased length of the distal phalanx of finger.
http://purl.obolibrary.org/obo/HP_0012300	Ureteral agenesis	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		Failure of the ureter to undergo development.
http://purl.obolibrary.org/obo/HP_0012301	Type II transferrin isoform profile	http://purl.obolibrary.org/obo/HP_0003160	Abnormal isoelectric focusing of serum transferrin		Abnormal transferrin isoform profile consistent with a type II congenital disorder of glycosylation.
http://purl.obolibrary.org/obo/HP_0012302	HSV encephalitis	http://purl.obolibrary.org/obo/HP_5210240	Unusual HSV infection		Infection of the brain parenchyma with herpes simplex virus, resulting in inflammation of the brain parenchyma with neurologic dysfunction.
http://purl.obolibrary.org/obo/HP_0012303	Abnormal aortic arch morphology	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		An anomaly of the arch of aorta.
http://purl.obolibrary.org/obo/HP_0012304	Hypoplastic aortic arch	http://purl.obolibrary.org/obo/HP_0012303	Abnormal aortic arch morphology		Underdevelopment of the arch of aorta.
http://purl.obolibrary.org/obo/HP_0012305	Coarctation of the descending aortic arch	http://purl.obolibrary.org/obo/HP_0012303	Abnormal aortic arch morphology		Narrowing or constriction of the aorta localized to the region of the descending trunk of arch of aorta.
http://purl.obolibrary.org/obo/HP_0012306	Abnormal rib ossification	http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification		An anomaly of the process of rib bone formation.
http://purl.obolibrary.org/obo/HP_0012307	Spatulate ribs	http://purl.obolibrary.org/obo/HP_0000885	Broad ribs		Ribs that are increased in width and taper to the posterior ends.
http://purl.obolibrary.org/obo/HP_0012308	Decreased circulating complement C9 concentration	http://purl.obolibrary.org/obo/HP_0033057	Decreased circulating terminal complement component concentration		Concentration of the complement component C9 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0012309	Cutaneous amyloidosis	http://purl.obolibrary.org/obo/HP_0020015	Amyloid deposition by anatomical site		The presence of amyloid deposition in the superficial dermis.
http://purl.obolibrary.org/obo/HP_0012310	Abnormal monocyte count	http://purl.obolibrary.org/obo/HP_0012144	Abnormal monocyte morphology		Abnormal increase or decrease of total monocytes, or their phenotype, in the blood, compared to a reference range for a given sex and age-group, measured ex vivo.
http://purl.obolibrary.org/obo/HP_0012311	Increased total monocyte count	http://purl.obolibrary.org/obo/HP_0012310	Abnormal monocyte count		Abnormal increase of absolute number of monocytes in the blood, per microlitre, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0012312	Decreased total monocyte count	http://purl.obolibrary.org/obo/HP_0012310	Abnormal monocyte count		Abnormal decrease of absolute number of monocytes in the blood, per microlitre, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0012313	Heberden node	http://purl.obolibrary.org/obo/HP_0006247	Enlarged interphalangeal joints		Bony swelling of the distal interphalangeal joint (DIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically.
http://purl.obolibrary.org/obo/HP_0012314	Bouchard node	http://purl.obolibrary.org/obo/HP_0006247	Enlarged interphalangeal joints		Bony swelling of the proximal interphalangeal joint (PIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically.
http://purl.obolibrary.org/obo/HP_0012315	Histiocytoma	http://purl.obolibrary.org/obo/HP_0012316	Fibrous tissue neoplasm		A neoplasm containing histiocytes.
http://purl.obolibrary.org/obo/HP_0012316	Fibrous tissue neoplasm	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		Any neoplasm composed of fibrous tissue.
http://purl.obolibrary.org/obo/HP_0012317	Sacroiliac arthritis	http://purl.obolibrary.org/obo/HP_0100781	Abnormal sacroiliac joint morphology		Inflammation of the sacroiliac joint, generally accompanied by lower back pain.
http://purl.obolibrary.org/obo/HP_0012318	Occipital neuralgia	http://purl.obolibrary.org/obo/HP_0033345	Neuralgia		A distinct type of headache characterized by piercing, throbbing, or electric-shock-like chronic pain in the upper neck, back of the head, and behind the ears, usually on one side.
http://purl.obolibrary.org/obo/HP_0012319	Absent pigmentation of the abdomen	http://purl.obolibrary.org/obo/HP_0200098	Absent skin pigmentation		Lack of skin pigmentation (coloring) of the abdomen.
http://purl.obolibrary.org/obo/HP_0012320	Absent pigmentation of the limbs	http://purl.obolibrary.org/obo/HP_0200098	Absent skin pigmentation		Lack of skin pigmentation (coloring) of the arms and legs.
http://purl.obolibrary.org/obo/HP_0012321	D-2-hydroxyglutaric aciduria	http://purl.obolibrary.org/obo/HP_0032278	2-hydroxyglutarate aciduria		An increased concentration of 2-hydroxyglutaric acid in the urine.
http://purl.obolibrary.org/obo/HP_0012322	Perifolliculitis	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Inflammation surrounding hair follicles.
http://purl.obolibrary.org/obo/HP_0012323	Sleep myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		Myoclonus that occurs during the initial phases of sleep.
http://purl.obolibrary.org/obo/HP_0012324	Myeloid leukemia	http://purl.obolibrary.org/obo/HP_0001909	Leukemia		A leukemia that originates from a myeloid cell, that is the blood forming cells of the bone marrow.
http://purl.obolibrary.org/obo/HP_0012325	Chronic myelomonocytic leukemia	http://purl.obolibrary.org/obo/HP_0012324	Myeloid leukemia		A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement.
http://purl.obolibrary.org/obo/HP_0012326	Abnormal celiac artery morphology	http://purl.obolibrary.org/obo/HP_0020317	Abnormal abdominal aorta branch artery morphology		An anomaly of the celiac artery.
http://purl.obolibrary.org/obo/HP_0012327	Celiac artery compression	http://purl.obolibrary.org/obo/HP_0012326	Abnormal celiac artery morphology		Compression of the celiac artery.
http://purl.obolibrary.org/obo/HP_0012328	Cementoma	http://purl.obolibrary.org/obo/HP_0100612	Odontogenic neoplasm		An odontogenic tumor of the cementum of tooth.
http://purl.obolibrary.org/obo/HP_0012329	Tufted angioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A vascular tumor of the skin and subcutaneous tissues and characterized by slow angiomatous proliferation.
http://purl.obolibrary.org/obo/HP_0012330	Pyelonephritis	http://purl.obolibrary.org/obo/HP_0000123	Nephritis		An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices.
http://purl.obolibrary.org/obo/HP_0012331	Abnormal autonomic nervous system morphology	http://purl.obolibrary.org/obo/HP_0002270	Abnormality of the autonomic nervous system		A structural abnormality of the autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0012333	Abnormal sudomotor regulation	http://purl.obolibrary.org/obo/HP_0012332	Abnormal autonomic nervous system physiology		An abnormal regulation of the sweat glands by the sympathetic nervous system associated with abnormal perspiration.
http://purl.obolibrary.org/obo/HP_0012334	Extrahepatic cholestasis	http://purl.obolibrary.org/obo/HP_0001396	Cholestasis		Impairment of bile flow due to obstruction in large bile ducts outside the liver.
http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		An anomaly in the processes involved in the maintenance of an internal equilibrium.
http://purl.obolibrary.org/obo/HP_0012338	Abnormal energy expenditure	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		Any anomaly in the utilization of energy (calories).
http://purl.obolibrary.org/obo/HP_0012339	Increased resting energy expenditure	http://purl.obolibrary.org/obo/HP_0012338	Abnormal energy expenditure		An increase in the number of calories used per unit time.
http://purl.obolibrary.org/obo/HP_0012340	Decreased resting energy expenditure	http://purl.obolibrary.org/obo/HP_0012338	Abnormal energy expenditure		A reduction in the number of calories used per unit time.
http://purl.obolibrary.org/obo/HP_0012341	Microprolactinoma	http://purl.obolibrary.org/obo/HP_0006767	Pituitary prolactin cell adenoma		A pituitary prolactin cell adenoma of less than 10 mm diameter.
http://purl.obolibrary.org/obo/HP_0012342	Macroprolactinoma	http://purl.obolibrary.org/obo/HP_0006767	Pituitary prolactin cell adenoma		A pituitary prolactin cell adenoma of more than 10 mm diameter.
http://purl.obolibrary.org/obo/HP_0012343	Decreased circulating ferritin concentration	http://purl.obolibrary.org/obo/HP_0040133	Abnormal circulating ferritin concentration		Abnormally reduced concentration of ferritin, a ubiquitous intracellular protein that stores iron, in the blood.
http://purl.obolibrary.org/obo/HP_0012344	Morphea	http://purl.obolibrary.org/obo/HP_0001072	Thickened skin		Isolated patches of hardened skin (scleroderma).
http://purl.obolibrary.org/obo/HP_0012345	Abnormal glycosylation	http://purl.obolibrary.org/obo/HP_0032245	Abnormal metabolism		An anomaly of a glycosylation process, i.e., a process involved in the covalent attachment of a glycosyl residue to a substrate molecule.
http://purl.obolibrary.org/obo/HP_0012346	Abnormal protein glycosylation	http://purl.obolibrary.org/obo/HP_0012345	Abnormal glycosylation		An anomaly of a protein glycosylation process, i.e., of a protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
http://purl.obolibrary.org/obo/HP_0012348	Decreased galactosylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation		A reduction in the amount of galactose residues of N-glycans.
http://purl.obolibrary.org/obo/HP_0012349	Abnormal sialylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation		An anomaly of the addition of sialic acids to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012350	Decreased sialylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012349	Abnormal sialylation of N-linked protein glycosylation		Decreased addition of sialic acids to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012351	Increased sialylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012349	Abnormal sialylation of N-linked protein glycosylation		Increased addition of sialic acids to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012352	Abnormal fucosylation of protein N-linked glycosylation	http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation		An anomaly of the addition of fucose sugar units to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012353	Decreased fucosylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012352	Abnormal fucosylation of protein N-linked glycosylation		Decreased addition of fucose sugar units to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012354	Increased fucosylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012352	Abnormal fucosylation of protein N-linked glycosylation		Increased addition of fucose sugar units to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012355	Abnormal mannosylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation		An anomaly of the addition of mannose to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012356	Decreased mannosylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012355	Abnormal mannosylation of N-linked protein glycosylation		Reduced addition of mannose to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012357	Increased mannosylation of N-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012355	Abnormal mannosylation of N-linked protein glycosylation		Increased addition of mannose to N-linked glycans.
http://purl.obolibrary.org/obo/HP_0012358	Abnormal protein O-linked glycosylation	http://purl.obolibrary.org/obo/HP_0012346	Abnormal protein glycosylation		An anomaly of protein O-linked glycosylation, i.e., of the process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of a serine or threonine residue.
http://purl.obolibrary.org/obo/HP_0012359	Abnormal fucosylation of O-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012358	Abnormal protein O-linked glycosylation		An anomaly of the addition of fucose sugar units to O-linked glycans.
http://purl.obolibrary.org/obo/HP_0012360	Decreased fucosylation of O-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012359	Abnormal fucosylation of O-linked protein glycosylation		A reduction of the addition of fucose sugar units to O-linked glycans.
http://purl.obolibrary.org/obo/HP_0012361	Increased fucosylation of O-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012359	Abnormal fucosylation of O-linked protein glycosylation		Increased addition of fucose sugar units to O-linked glycans.
http://purl.obolibrary.org/obo/HP_0012362	Abnormal sialylation of O-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012358	Abnormal protein O-linked glycosylation		An anomaly of the addition of sialic acids to O-linked glycans.
http://purl.obolibrary.org/obo/HP_0012363	Decreased sialylation of O-linked protein glycosylation	http://purl.obolibrary.org/obo/HP_0012362	Abnormal sialylation of O-linked protein glycosylation		An reduced addition of sialic acids to O-linked glycans.
http://purl.obolibrary.org/obo/HP_0012364	Decreased urinary potassium	http://purl.obolibrary.org/obo/HP_0012598	Abnormal urine potassium concentration		A decreased concentration of potassium(1+) in the urine.
http://purl.obolibrary.org/obo/HP_0012365	Hypophosphaturia	http://purl.obolibrary.org/obo/HP_0012599	Abnormal urine phosphate concentration		An abnormally decreased phosphate concentration in the urine.
http://purl.obolibrary.org/obo/HP_0012366	Basilar invagination	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		Projection of the tip of the dens more than 5 mm above a line joining the hard palate to the posterior lip of the foramen magnum (Chamberlain's line) or the tip of the dens is greater than 7 mm above McGregor's line (the back of the hard palate to the lowest point of the occipital squama).
http://purl.obolibrary.org/obo/HP_0012367	Extra fontanelles	http://purl.obolibrary.org/obo/HP_0011328	Abnormal fontanelle morphology		Bony defects situated along the cranial suture lines or at the junction of the bone plates of the skull.
http://purl.obolibrary.org/obo/HP_0012368	Flat face	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		Absence of concavity or convexity of the face when viewed in profile.
http://purl.obolibrary.org/obo/HP_0012370	Prominence of the zygomatic bone	http://purl.obolibrary.org/obo/HP_0010668	Abnormal zygomatic bone morphology		Large or prominent malar surface of the zygomatic bone of the skull, which is convex and forms the prominence of the 'cheek bones'.
http://purl.obolibrary.org/obo/HP_0012371	Hyperplasia of midface	http://purl.obolibrary.org/obo/HP_0000309	Abnormal midface morphology		Abnormally anterior positioning of the infraorbital and perialar regions, or increased convexity of the face, or increased nasolabial angle. The midface includes the maxilla, the cheeks, the zygomas, and the infraorbital and perialar regions of the face
http://purl.obolibrary.org/obo/HP_0012375	Chemosis	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Edema (swelling) of the bulbar conjunctiva.
http://purl.obolibrary.org/obo/HP_0012376	Microphakia	http://purl.obolibrary.org/obo/HP_0008063	Aplasia/Hypoplasia of the lens		Abnormal smallness of the lens.
http://purl.obolibrary.org/obo/HP_0012377	Hemianopia	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		Partial or complete loss of vision in one half of the visual field of one or both eyes.
http://purl.obolibrary.org/obo/HP_0012378	Fatigue	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A subjective feeling of tiredness characterized by a lack of energy and motivation.
http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity	http://purl.obolibrary.org/obo/HP_0034684	Abnormal enzyme concentration or activity		Concentration or activity of an enzyme is above or below the limits of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0012380	Reduced tissue carnitine O-palmitoyltransferase 2 activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Reduced carnitine O-palmitoyltransferase (CPT II; EC 2.3.1.21) activity or level, leading to a reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. (CPT II activity can be measured in tissues including fibroblasts, lymphoblasts, and skeletal muscle.
http://purl.obolibrary.org/obo/HP_0012381	Delayed self-feeding during toddler years	http://purl.obolibrary.org/obo/HP_0011968	Feeding difficulties		A delay in the development of skills required to feed oneself in the toddler period (between one and three years of age).
http://purl.obolibrary.org/obo/HP_0012382	Left-to-right shunt	http://purl.obolibrary.org/obo/HP_0001693	Cardiac shunt		Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the left side of the heart to the right.
http://purl.obolibrary.org/obo/HP_0012383	Bidirectional shunt	http://purl.obolibrary.org/obo/HP_0001693	Cardiac shunt		Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from both right side of the heart to the left and vice versa.
http://purl.obolibrary.org/obo/HP_0012386	Absent hallux	http://purl.obolibrary.org/obo/HP_0008362	Aplasia/Hypoplasia of the hallux		Aplasia of the hallux, that is, a development defect such that the big toe does not develop.
http://purl.obolibrary.org/obo/HP_0012388	Acute bronchitis	http://purl.obolibrary.org/obo/HP_0012387	Bronchitis		Inflammation of the large airways of the lung with rapid onset and short course usually associated with cough, mucus production, shortness of breath, wheezing, and chest tightness.
http://purl.obolibrary.org/obo/HP_0012389	Appendicular hypotonia	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		Muscular hypotonia of one or more limbs.
http://purl.obolibrary.org/obo/HP_0012390	Anal fissure	http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology		A small tear in the thin, moist tissue (mucosa) that lines the anus. It appears as a crack or slit in the mucous membrane of the anus.
http://purl.obolibrary.org/obo/HP_0012391	Hyporeflexia of upper limbs	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		Reduced intensity of muscle tendon reflexes in the upper limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping.
http://purl.obolibrary.org/obo/HP_0012392	Jaw hyporeflexia	http://purl.obolibrary.org/obo/HP_0045037	Abnormality of jaw muscles		Reduced intensity of muscle tendon reflexes in jaw.
http://purl.obolibrary.org/obo/HP_0012394	Iodine contrast allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Allergy to iodine contrast media used in radiological studies.
http://purl.obolibrary.org/obo/HP_0012395	Seasonal allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		An allergy experienced at a particular time of year when trees or grasses pollinate and elicit an allergic reaction.
http://purl.obolibrary.org/obo/HP_0012396	Biliary dyskinesia	http://purl.obolibrary.org/obo/HP_0012439	Abnormal biliary tract physiology		A motility disorder characterized by biliary colic in the absence of gallstones with a reduced gallbladder ejection fraction.
http://purl.obolibrary.org/obo/HP_0012397	Aortic atherosclerotic lesion	http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis		The presence of atheromas or atherosclerotic plaques in the aorta.
http://purl.obolibrary.org/obo/HP_0012398	Peripheral edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		An abnormal accumulation of interstitial fluid in the soft tissues of the limbs.
http://purl.obolibrary.org/obo/HP_0012399	Pressure ulcer	http://purl.obolibrary.org/obo/HP_0200042	Skin ulcer		A type of ulcer that is caused when an area of skin is subject to pressure over a prolonged period of time, ranging in range in severity from patches of discolored skin to open wounds that expose the underlying bone or muscle. The most common sites are the sacrum, coccyx, heels and the hips.
http://purl.obolibrary.org/obo/HP_0012400	Abnormal circulating aldolase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormal concentration of aldolase in the serum. Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.
http://purl.obolibrary.org/obo/HP_0012401	Abnormal urine alpha-ketoglutarate concentration	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		A deviation from normal of the concentration of 2-oxoglutaric acid in the urine.
http://purl.obolibrary.org/obo/HP_0012402	Increased urine alpha-ketoglutarate concentration	http://purl.obolibrary.org/obo/HP_0012401	Abnormal urine alpha-ketoglutarate concentration		A greater than normal concentration of 2-oxoglutaric acid in the urine.
http://purl.obolibrary.org/obo/HP_0012403	Decreased urine alpha-ketoglutarate concentration	http://purl.obolibrary.org/obo/HP_0012401	Abnormal urine alpha-ketoglutarate concentration		A lower than normal concentration of 2-oxoglutaric acid in the urine.
http://purl.obolibrary.org/obo/HP_0012404	Abnormal urine citrate concentration	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		A deviation from normal of the concentration of citrate(3-) in the urine.
http://purl.obolibrary.org/obo/HP_0012405	Hypocitraturia	http://purl.obolibrary.org/obo/HP_0012404	Abnormal urine citrate concentration		A lower than normal concentration of citrate(3-) in the urine.
http://purl.obolibrary.org/obo/HP_0012406	Hypercitraturia	http://purl.obolibrary.org/obo/HP_0012404	Abnormal urine citrate concentration		A greater than normal concentration of citrate(3-) in the urine.
http://purl.obolibrary.org/obo/HP_0012407	Scissor gait	http://purl.obolibrary.org/obo/HP_0031958	Spastic paraparetic gait		A type of spastic paraparetic gait in which the muscle tone in the adductors is marked. It is characterized by hypertonia and flexion in the legs, hips and pelvis accompanied by extreme adduction leading to the knees and thighs hitting, or sometimes even crossing, in a scissors-like movement. The opposing muscles (abductors) become comparatively weak from lack of use.
http://purl.obolibrary.org/obo/HP_0012408	Medullary nephrocalcinosis	http://purl.obolibrary.org/obo/HP_0000121	Nephrocalcinosis		The deposition of calcium salts in the parenchyma of the renal medulla (innermost part of the kidney).
http://purl.obolibrary.org/obo/HP_0012409	Cortical nephrocalcinosis	http://purl.obolibrary.org/obo/HP_0000121	Nephrocalcinosis		The deposition of calcium salts in the parenchyma of the renal cortex (the outer portion of the kidney between the renal capsule and the renal medulla).
http://purl.obolibrary.org/obo/HP_0012410	Pure red cell aplasia	http://purl.obolibrary.org/obo/HP_0012131	Abnormal number of erythroid precursors		A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction.
http://purl.obolibrary.org/obo/HP_0012411	Premature pubarche	http://purl.obolibrary.org/obo/HP_0000826	Precocious puberty		The onset of growth of pubic hair at an earlier age than normal.
http://purl.obolibrary.org/obo/HP_0012412	Premature adrenarche	http://purl.obolibrary.org/obo/HP_0100000	Early onset of sexual maturation		Onset of adrenarche at an earlier age than usual.
http://purl.obolibrary.org/obo/HP_0012413	Notched primary central incisor	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		The presence of a V-shaped indentation (notch) in the primary central incisor.
http://purl.obolibrary.org/obo/HP_0012414	Duodenal atrophy	http://purl.obolibrary.org/obo/HP_0002246	Abnormal duodenum morphology		Wasting or decrease in size of all or part of the duodenum.
http://purl.obolibrary.org/obo/HP_0012415	Abnormal blood gas level	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood.
http://purl.obolibrary.org/obo/HP_0012416	Hypercapnia	http://purl.obolibrary.org/obo/HP_0500164	Abnormal blood carbon dioxide level		Abnormally elevated blood carbon dioxide (CO2) level.
http://purl.obolibrary.org/obo/HP_0012417	Hypocapnia	http://purl.obolibrary.org/obo/HP_0500164	Abnormal blood carbon dioxide level		Abnormally reduced blood carbon dioxide (CO2) level.
http://purl.obolibrary.org/obo/HP_0012418	Hypoxemia	http://purl.obolibrary.org/obo/HP_0500165	Abnormal blood oxygen level		An abnormally low level of blood oxygen.
http://purl.obolibrary.org/obo/HP_0012419	Hyperoxemia	http://purl.obolibrary.org/obo/HP_0500165	Abnormal blood oxygen level		An abnormally high level of blood oxygen.
http://purl.obolibrary.org/obo/HP_0012420	Meconium stained amniotic fluid	http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid		Amniotic fluid containing the earliest stools of a mammalian infant.
http://purl.obolibrary.org/obo/HP_0012421	Congenital absence of foreskin	http://purl.obolibrary.org/obo/HP_0100587	Abnormal preputium morphology		Congenital lack of the skin of prepuce of penis, that is, of the double-layered fold of skin and mucous membrane that covers the glans penis.
http://purl.obolibrary.org/obo/HP_0012422	Villous hypertrophy of choroid plexus	http://purl.obolibrary.org/obo/HP_0007376	Abnormal choroid plexus morphology		Overgrowth of the choroid plexus.
http://purl.obolibrary.org/obo/HP_0012423	Colonic inertia	http://purl.obolibrary.org/obo/HP_0012700	Abnormal large intestine physiology		The inability of the colon to modify stool to an acceptable consistency and move the stool from the cecum to the rectosigmoid area at least once every three days.
http://purl.obolibrary.org/obo/HP_0012424	Chorioretinitis	http://purl.obolibrary.org/obo/HP_0000532	Abnormal chorioretinal morphology		An inflammation of the choroid and retina.
http://purl.obolibrary.org/obo/HP_0012425	Stercoral ulcer	http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer		An ulcer of the colon due to pressure and irritation from retained fecal masses.
http://purl.obolibrary.org/obo/HP_0012426	Optic disc drusen	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		Optic disc drusen are acellular, calcified deposits within the optic nerve head. Optic disc drusen are congenital and developmental anomalies of the optic nerve head, representing hyaline-containing bodies that, over time, appear as elevated, lumpy irregularities on the anterior portion of the optic nerve.
http://purl.obolibrary.org/obo/HP_0012427	Increased femoral anteversion	http://purl.obolibrary.org/obo/HP_0031069	Abnormal femoral torsion		An increased degree of femoral version, which is defined as the angular difference between axis of femoral neck and transcondylar axis of the knee. Thus, femoral anteversion is an inward twisting of the femur that causes the knees and feet to turn inward.
http://purl.obolibrary.org/obo/HP_0012428	Prominent calcaneus	http://purl.obolibrary.org/obo/HP_0008364	Abnormality of the calcaneus		Protruding heel bone, or calcaneus.
http://purl.obolibrary.org/obo/HP_0012429	Aplasia/Hypoplasia of the cerebral white matter	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		Absence or underdevelopment of the cerebral white matter.
http://purl.obolibrary.org/obo/HP_0012430	Cerebral white matter hypoplasia	http://purl.obolibrary.org/obo/HP_0012429	Aplasia/Hypoplasia of the cerebral white matter		Underdevelopment of the cerebral white matter.
http://purl.obolibrary.org/obo/HP_0012431	Episodic fatigue	http://purl.obolibrary.org/obo/HP_0012378	Fatigue		Intermittent and recurrent bouts of a subjective feeling of tiredness characterized by a lack of energy and motivation.
http://purl.obolibrary.org/obo/HP_0012432	Chronic fatigue	http://purl.obolibrary.org/obo/HP_0012378	Fatigue		Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.
http://purl.obolibrary.org/obo/HP_0012434	Delayed early-childhood social milestone development	http://purl.obolibrary.org/obo/HP_0025732	Abnormal social development		A failure to meet one or more age-related milestones of social behavior.
http://purl.obolibrary.org/obo/HP_0012435	Ventral shortening of foreskin	http://purl.obolibrary.org/obo/HP_0100587	Abnormal preputium morphology		Reduction in length of the ventral (lower) skin of prepuce of penis.
http://purl.obolibrary.org/obo/HP_0012436	Nonocclusive coronary artery atherosclerosis	http://purl.obolibrary.org/obo/HP_0001677	Coronary artery atherosclerosis		Coronary disease that has not progressed to the point of causing significant occlusion (blockage) of the coronary arteries.
http://purl.obolibrary.org/obo/HP_0012441	Sphincter of Oddi dyskinesia	http://purl.obolibrary.org/obo/HP_0012396	Biliary dyskinesia		Reduced motility through the sphincter of Oddi, resulting in impedance of bile and pancreatic juice flow from the common bile duct into the duodenum.
http://purl.obolibrary.org/obo/HP_0012442	Gallbladder dyskinesia	http://purl.obolibrary.org/obo/HP_0012396	Biliary dyskinesia		Reduced motility of the gallbladder with reduced emptying fraction.
http://purl.obolibrary.org/obo/HP_0012446	Decreased CSF 5-methyltetrahydrofolate concentration	http://purl.obolibrary.org/obo/HP_0020351	Abnormal CSF folate concentration		A reduced concentration of 5-methyltetrahydrofolate(2-) in the cerebrospinal fluid (CSF). 5-methyltetrahydrofolate is the active folate metabolite.
http://purl.obolibrary.org/obo/HP_0012449	Sacroiliac joint synovitis	http://purl.obolibrary.org/obo/HP_0100781	Abnormal sacroiliac joint morphology		Inflammation of the synovial membrane of the sacroiliac joint.
http://purl.obolibrary.org/obo/HP_0012450	Chronic constipation	http://purl.obolibrary.org/obo/HP_0002019	Constipation		Constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard stools, and a sensation of anorectal obstruction or incomplete defecation.
http://purl.obolibrary.org/obo/HP_0012451	Acute constipation	http://purl.obolibrary.org/obo/HP_0002019	Constipation		Constipation of sudden onset and lasting for less than three months.
http://purl.obolibrary.org/obo/HP_0012452	Restless legs	http://purl.obolibrary.org/obo/HP_5200300	Abnormal movement during sleep		An irresistible urge to move the legs, usually accompanied by unpleasant sensations deep within the limbs. Symptoms typically begin or worsen during periods of rest or inactivity, are most pronounced in the evening or at night, and are temporarily relieved by movement such as walking or stretching. The disturbance often interferes with the initiation or maintenance of sleep.
http://purl.obolibrary.org/obo/HP_0012453	Bilateral wrist flexion contracture	http://purl.obolibrary.org/obo/HP_0001239	Wrist flexion contracture		A chronic loss of wrist joint motion on the right and left sides.
http://purl.obolibrary.org/obo/HP_0012454	Unilateral wrist flexion contracture	http://purl.obolibrary.org/obo/HP_0001239	Wrist flexion contracture		A chronic loss of wrist joint motion on one side only.
http://purl.obolibrary.org/obo/HP_0012456	Medial arterial calcification	http://purl.obolibrary.org/obo/HP_0003207	Arterial calcification		Calcification, that is, pathological deposition of calcium salts in the tunica media of arteries.
http://purl.obolibrary.org/obo/HP_0012457	Medial calcification of medium-sized arteries	http://purl.obolibrary.org/obo/HP_0012456	Medial arterial calcification		Calcification, that is, pathological deposition of calcium salts in the tunica media of medium-sized (muscular or distributive) arteries.
http://purl.obolibrary.org/obo/HP_0012458	Medial calcification of small arteries	http://purl.obolibrary.org/obo/HP_0012456	Medial arterial calcification		Calcification, that is, pathological deposition of calcium salts in the tunica media of small arteries.
http://purl.obolibrary.org/obo/HP_0012459	Hypnic headache	http://purl.obolibrary.org/obo/HP_0002315	Headache		A headache disorder that occurs exclusively at night, waking the affected individual from sleep.
http://purl.obolibrary.org/obo/HP_0012460	Dysmorphic inferior cerebellar vermis	http://purl.obolibrary.org/obo/HP_0002334	Abnormal cerebellar vermis morphology		A structural anomaly of the inferior portion of the vermis of cerebellum.
http://purl.obolibrary.org/obo/HP_0012461	Bacteriuria	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		The presence of bacteria in the urine.
http://purl.obolibrary.org/obo/HP_0012462	Chin myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		Involuntary and irregular twitches of the chin.
http://purl.obolibrary.org/obo/HP_0012463	Elevated transferrin saturation	http://purl.obolibrary.org/obo/HP_0040135	Abnormal transferrin saturation		An above normal level of saturation of serum transferrin with iron.
http://purl.obolibrary.org/obo/HP_0012464	Decreased transferrin saturation	http://purl.obolibrary.org/obo/HP_0040135	Abnormal transferrin saturation		A below normal level of saturation of serum transferrin with iron.
http://purl.obolibrary.org/obo/HP_0012465	Elevated hepatic iron concentration	http://purl.obolibrary.org/obo/HP_0040134	Abnormal hepatic iron concentration		An increased level of iron in liver tissues.
http://purl.obolibrary.org/obo/HP_0012466	Chronic respiratory acidosis	http://purl.obolibrary.org/obo/HP_0005972	Respiratory acidosis		Longstanding impairment in ventilation such that the partial pressure of carbon dioxide (PaCO2) is elevated above the upper limit of the reference range (more than 45 mm Hg), with a normal or near-normal pH secondary to renal compensation and an elevated serum bicarbonate levels (more than30 mEq/L).
http://purl.obolibrary.org/obo/HP_0012467	Acute respiratory acidosis	http://purl.obolibrary.org/obo/HP_0005972	Respiratory acidosis		Sudden onset of impairment in ventilation such that the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues, leading to an elevation of the partial pressure of carbon dioxide (PaCO2) above the normal limits (more than 45 mm Hg) with an accompanying acidemia (pH less than 7.35).
http://purl.obolibrary.org/obo/HP_0012469	Infantile spasms	http://purl.obolibrary.org/obo/HP_0011097	Epileptic spasm		Infantile spasms represent a subset of "epileptic spasms". Infantile Spasms are epileptic spasms starting in the first year of life (infancy).
http://purl.obolibrary.org/obo/HP_0012470	Setting-sun eye phenomenon	http://purl.obolibrary.org/obo/HP_0000597	Ophthalmoparesis		An ophthalmologic sign in young children resulting from upward-gaze paresis. In this condition, the eyes appear driven downward, the sclera may be seen between the upper eyelid and the iris, and part of the lower pupil may be covered by the lower eyelid.
http://purl.obolibrary.org/obo/HP_0012473	Tongue atrophy	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Wasting of the tongue.
http://purl.obolibrary.org/obo/HP_0012474	Carotid artery occlusion	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		Complete obstruction of a carotid artery.
http://purl.obolibrary.org/obo/HP_0012476	Decreased circulating specific pneumococcal antibody concentration	http://purl.obolibrary.org/obo/HP_0002848	Decreased specific anti-polysaccharide antibody concentration		The concentration in the blood circulation of specific immunoglobulins directed against pneumococci is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0012477	Vocal tremor	http://purl.obolibrary.org/obo/HP_0002345	Action tremor		A wavering, unsteady voice that reflects involuntary and approximately sinusoidal oscillation of motor unit firings of laryngeal muscles. Vocal tremor results in low frequency modulations of voice frequency or amplitude and intermittent voice instability.
http://purl.obolibrary.org/obo/HP_0012478	Temporomandibular joint ankylosis	http://purl.obolibrary.org/obo/HP_0010754	Abnormality of the temporomandibular joint		Bony fusion of the mandibular condyle to the base of the skull, resulting in limitation of jaw opening.
http://purl.obolibrary.org/obo/HP_0012479	Temporomandibular joint crepitus	http://purl.obolibrary.org/obo/HP_0010754	Abnormality of the temporomandibular joint		Noises from the temporomandibular joint during mandibular movement (e.g., chewing). Temporomandibular joint crepitus is often described as a clicking, popping, grating sound.
http://purl.obolibrary.org/obo/HP_0012480	Abnormal cerebral vein morphology	http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology		An anomaly of cerebral veins.
http://purl.obolibrary.org/obo/HP_0012481	Cerebral venous angioma	http://purl.obolibrary.org/obo/HP_0012480	Abnormal cerebral vein morphology		A congenital malformation of veins which drain normal brain characterized by a caput medusae or an umbrellalike convergence of multiple venules on a single, or occasionally multiple, enlarged parenchymal or medullary vein, like the trunk of a tree or the shank of an umbrella. This dilated terminal vein penetrates the cortex to drain either (a) superficially to cortical veins or sinuses, (b) deeply to subependymal veins of the lateral ventricle and then into the galenic system, (c) to the fourth ventricle and then to the pontomesencephalic vein, or (d) to the precentral cerebellar vein and into the galenic system.
http://purl.obolibrary.org/obo/HP_0012482	Frontal venous angioma	http://purl.obolibrary.org/obo/HP_0012481	Cerebral venous angioma		A venous angioma of the frontal lobe of the brain.
http://purl.obolibrary.org/obo/HP_0012483	Abnormal alpha granules	http://purl.obolibrary.org/obo/HP_0011883	Abnormal platelet granules		Defective structure, size or content of alpha granules, platelet organelles that contain several growth factors destined for release during platelet activation at sites of vessel wall injury.
http://purl.obolibrary.org/obo/HP_0012484	Abnormal dense granules	http://purl.obolibrary.org/obo/HP_0011883	Abnormal platelet granules		Defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium, histamine and serotonin.
http://purl.obolibrary.org/obo/HP_0012485	Abnormal surface-connected open canalicular system	http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology		An anomaly of the invaginations of the surface membrane that form the open canalicular system (OCS). The OCS serve as the pathway for transport of substances into the cells and as conduits for the discharge of alpha granule products secreted during the platelet release reaction.
http://purl.obolibrary.org/obo/HP_0012486	Myelitis	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		Inflammation of the spinal cord.
http://purl.obolibrary.org/obo/HP_0012487	Cerebellopontine angle arachnoid cyst	http://purl.obolibrary.org/obo/HP_0100702	Arachnoid cyst		An arachnoid cyst located at the margin of the cerebellum and pons.
http://purl.obolibrary.org/obo/HP_0012488	Intraventricular arachnoid cyst	http://purl.obolibrary.org/obo/HP_0100702	Arachnoid cyst		An arachnoid cyst located within the ventricular system.
http://purl.obolibrary.org/obo/HP_0012489	Suprasellar arachnoid cyst	http://purl.obolibrary.org/obo/HP_0100702	Arachnoid cyst		An arachnoid cyst that progressively enlarges from an abnormality in the membrane of Liliequist or in the interpeduncular cistern, and typically, expands from the prepontine space, displacing the floor of the third ventricle upwards, the pituitary stalk and optic chiasm upwards and forwards, and the mammillary bodies upwards and backwards.
http://purl.obolibrary.org/obo/HP_0012490	Panniculitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of subcutaneous adipose tissue.
http://purl.obolibrary.org/obo/HP_0012491	Abnormal dense tubular system	http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology		An anomaly of the intracellular membrane complexes known as the dense tubular system.
http://purl.obolibrary.org/obo/HP_0012492	Cerebral artery stenosis	http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology		Narrowing or constriction of the inner surface (lumen) of a cerebral artery.
http://purl.obolibrary.org/obo/HP_0012493	Middle cerebral artery stenosis	http://purl.obolibrary.org/obo/HP_0012492	Cerebral artery stenosis		Narrowing or constriction of the inner surface (lumen) of the middle cerebral artery.
http://purl.obolibrary.org/obo/HP_0012494	Anterior cerebral artery stenosis	http://purl.obolibrary.org/obo/HP_0012492	Cerebral artery stenosis		Narrowing or constriction of the inner surface (lumen) of the anterior cerebral artery.
http://purl.obolibrary.org/obo/HP_0012495	Posterior cerebral artery stenosis	http://purl.obolibrary.org/obo/HP_0012492	Cerebral artery stenosis		Narrowing or constriction of the inner surface (lumen) of the posterior cerebral artery.
http://purl.obolibrary.org/obo/HP_0012496	Reduced maximal inspiratory pressure	http://purl.obolibrary.org/obo/HP_0004347	Weakness of muscles of respiration		A decrease in the maximum amount of negative pressure a person can generate during an inhalation.
http://purl.obolibrary.org/obo/HP_0012497	Reduced maximal expiratory pressure	http://purl.obolibrary.org/obo/HP_0004347	Weakness of muscles of respiration		A decrease in the maximum amount of pressure of expired air achieved by a person after a full inspiration.
http://purl.obolibrary.org/obo/HP_0012498	Nuchal cord	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		A complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times.
http://purl.obolibrary.org/obo/HP_0012499	Descending aortic dissection	http://purl.obolibrary.org/obo/HP_0002647	Aortic dissection		A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space.
http://purl.obolibrary.org/obo/HP_0012500	Verrucous papule	http://purl.obolibrary.org/obo/HP_0200034	Papule		A wartlike (with multiple small elevated projections) papule.
http://purl.obolibrary.org/obo/HP_0012501	Abnormal brainstem white matter morphology	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		An anomaly of the white matter of brainstem.
http://purl.obolibrary.org/obo/HP_0012502	Abnormality of the internal capsule	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		An anomaly of the internal capsule, which is an area of white matter in the brain that separates the caudate nucleus and the thalamus from the putamen and the globus pallidus.
http://purl.obolibrary.org/obo/HP_0012503	Abnormal pituitary gland morphology	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		An anomaly of the pituitary gland.
http://purl.obolibrary.org/obo/HP_0012504	Abnormal size of pituitary gland	http://purl.obolibrary.org/obo/HP_0012503	Abnormal pituitary gland morphology		A deviation from the normal size of the pituitary gland.
http://purl.obolibrary.org/obo/HP_0012505	Enlarged pituitary gland	http://purl.obolibrary.org/obo/HP_0012504	Abnormal size of pituitary gland		An abnormally increased size of the pituitary gland.
http://purl.obolibrary.org/obo/HP_0012506	Small pituitary gland	http://purl.obolibrary.org/obo/HP_0012504	Abnormal size of pituitary gland		An abnormally decreased size of the pituitary gland.
http://purl.obolibrary.org/obo/HP_0012507	Weakness of orbicularis oculi muscle	http://purl.obolibrary.org/obo/HP_0001324	Muscle weakness		Reduced strength of the orbicularis oculi, the circumorbital muscle in the face that closes the eyelid.
http://purl.obolibrary.org/obo/HP_0012508	Metamorphopsia	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank.
http://purl.obolibrary.org/obo/HP_0012510	Extra-axial cerebrospinal fluid accumulation	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		An increased amount of cerebrospinal fluid (CSF) in the subarachnoid space.
http://purl.obolibrary.org/obo/HP_0012511	Temporal optic disc pallor	http://purl.obolibrary.org/obo/HP_0000543	Optic disc pallor		A pale yellow discoloration of the temporal (lateral) portion of the optic disc.
http://purl.obolibrary.org/obo/HP_0012512	Diffuse optic disc pallor	http://purl.obolibrary.org/obo/HP_0000543	Optic disc pallor		A pale yellow discoloration of the entire optic disc.
http://purl.obolibrary.org/obo/HP_0012513	Upper limb pain	http://purl.obolibrary.org/obo/HP_0009763	Limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the arm.
http://purl.obolibrary.org/obo/HP_0012514	Lower limb pain	http://purl.obolibrary.org/obo/HP_0009763	Limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg.
http://purl.obolibrary.org/obo/HP_0012515	Hip flexor weakness	http://purl.obolibrary.org/obo/HP_0003749	Pelvic girdle muscle weakness		Reduced ability to flex the femur, that is, to pull the knee upward.
http://purl.obolibrary.org/obo/HP_0012516	Tetralogy of Fallot with pulmonary atresia	http://purl.obolibrary.org/obo/HP_0001636	Tetralogy of Fallot		An extreme form of tetralogy of Fallot characterized by absence of flow from the right ventricle to the pulmonary arteries.
http://purl.obolibrary.org/obo/HP_0012517	Reduced circulating catalase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity or concentration of catalase in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0012518	Abnormal circle of Willis morphology	http://purl.obolibrary.org/obo/HP_0009145	Abnormal cerebral artery morphology		An anomaly of the circle of Willis, also known as the cerebral arterial circle.
http://purl.obolibrary.org/obo/HP_0012519	Hypoplastic posterior communicating artery	http://purl.obolibrary.org/obo/HP_0031772	Abnormal posterior circulating artery morphology		A developmental anomnaly characterized by underdevelopment of the posterior communicating artery.
http://purl.obolibrary.org/obo/HP_0012520	Dilation of Virchow-Robin spaces	http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology		Increased dimensions of the Virchow-Robin spaces (also known as perivascular spaces), which surround the walls of vessels as they course from the subarachnoid space through the brain parenchyma. Perivascular spaces are commonly microscopic, and not visible on conventional neuroimaging. This term refers to an increase of size of these spaces such that they are visible on neuroimaging (usually magnetic resonance imaging). The dilatations are regular cavities that always contain a patent artery.
http://purl.obolibrary.org/obo/HP_0012521	Optic nerve aplasia	http://purl.obolibrary.org/obo/HP_0008058	Aplasia/Hypoplasia of the optic nerve		Congenital absence of the optic nerve.
http://purl.obolibrary.org/obo/HP_0012522	Spider hemangioma	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		A form of telangiectasis characterized by a central elevated red dot the size of a pinhead, representing an arteriole, with numerous small blood vessels that radiate out thereby resembling the legs of a spider. Characteristically, compression of the central arteriole causes the entire lesion to blanch, and the lesion quickly refills once the compression is released.
http://purl.obolibrary.org/obo/HP_0012523	Oral aversion	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		Reluctance or refusal of a child to be breastfed or eat, manifested as gagging, vomiting, turning head away from food, or avoidance of sensation in or around the mouth (i.e. toothbrushing or face-washing).
http://purl.obolibrary.org/obo/HP_0012524	Abnormal platelet shape	http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology		A deviation from the normal discoid platelet shape.
http://purl.obolibrary.org/obo/HP_0012525	Abnormal alpha granule distribution	http://purl.obolibrary.org/obo/HP_0012483	Abnormal alpha granules		An anomalous location and arrangement of platelet alpha granules.
http://purl.obolibrary.org/obo/HP_0012526	Absence of alpha granules	http://purl.obolibrary.org/obo/HP_0012528	Abnormal number of alpha granules		A lack of platelet alpha granules. This typically results in the gray appearance of platelets in giemsa stained blood smears.
http://purl.obolibrary.org/obo/HP_0012527	Abnormal alpha granule content	http://purl.obolibrary.org/obo/HP_0012483	Abnormal alpha granules		A deviation from the normal contents of the platelet alpha granules, which normally contain hemostatic proteins such as fibrinogen, von Willebrand factor, and growth factors such as platelet-derived growth factor.
http://purl.obolibrary.org/obo/HP_0012528	Abnormal number of alpha granules	http://purl.obolibrary.org/obo/HP_0012483	Abnormal alpha granules		A deviation from the normal count of alpha granules per thrombocyte.
http://purl.obolibrary.org/obo/HP_0012529	Abnormal dense granule content	http://purl.obolibrary.org/obo/HP_0012484	Abnormal dense granules		A deviation from the normal contents of the platelet alpha granules, which normally contain adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin, calcium, and pyrophosphate, which are secreted when platelets are activated.
http://purl.obolibrary.org/obo/HP_0012530	Abnormal number of dense granules	http://purl.obolibrary.org/obo/HP_0012484	Abnormal dense granules		A deviation from the normal count of dense granules per thrombocyte.
http://purl.obolibrary.org/obo/HP_0012531	Pain	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.
http://purl.obolibrary.org/obo/HP_0012532	Chronic pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.
http://purl.obolibrary.org/obo/HP_0012533	Allodynia	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain due to a stimulus that does not normally provoke pain.
http://purl.obolibrary.org/obo/HP_0012534	Dysesthesia	http://purl.obolibrary.org/obo/HP_0010832	Abnormality of pain sensation		Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.
http://purl.obolibrary.org/obo/HP_0012535	Abnormal synaptic transmission	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process.
http://purl.obolibrary.org/obo/HP_0012536	Maternal anticardiolipin antibody positive	http://purl.obolibrary.org/obo/HP_0011437	Maternal autoimmune disease		The presence of circulating autoantibodies to anticardiolipin in the mother.
http://purl.obolibrary.org/obo/HP_0012538	Gluten intolerance	http://purl.obolibrary.org/obo/HP_0001984	Intolerance to protein		A detrimental reaction to the presence of gluten in food, which may include abdominal pain, fatigue, headaches and paresthesia, or celiac disease.
http://purl.obolibrary.org/obo/HP_0012539	Non-Hodgkin lymphoma	http://purl.obolibrary.org/obo/HP_0002665	Lymphoma		A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells.
http://purl.obolibrary.org/obo/HP_0012540	Axillary epidermoid cyst	http://purl.obolibrary.org/obo/HP_0200040	Epidermoid cyst		An epidermoid cyst in the armpit.
http://purl.obolibrary.org/obo/HP_0012541	Cephalohematoma	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		Hemorrhage between the skull and periosteum of a newborn resulting from rupture of blood vessels that cross the periosteum.
http://purl.obolibrary.org/obo/HP_0012542	Onychauxis	http://purl.obolibrary.org/obo/HP_0001805	Onychogryphosis		Thickened nails without deformity.
http://purl.obolibrary.org/obo/HP_0012543	Hemosiderinuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The presence of hemosiderin in the urine.
http://purl.obolibrary.org/obo/HP_0012544	Elevated circulating aldolase concentration	http://purl.obolibrary.org/obo/HP_0012400	Abnormal circulating aldolase concentration		Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0012545	Reduced circulating aldolase concentration	http://purl.obolibrary.org/obo/HP_0012400	Abnormal circulating aldolase concentration		Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0012546	Skewed maternal X inactivation	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		A deviation from equal (50%) inactivation of each parental X chromosome in maternal cells.
http://purl.obolibrary.org/obo/HP_0012548	Fatty replacement of skeletal muscle	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers
http://purl.obolibrary.org/obo/HP_0012549	Conjunctival lipoma	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		A lipoma (a benign tumor composed of adipose tissue) located in the conjunctiva.
http://purl.obolibrary.org/obo/HP_0012550	Colonic varices	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		The presence of varices (enlarged and convoluted blood vessels) in the colon.
http://purl.obolibrary.org/obo/HP_0012551	Absent neutrophil specific granules	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		Lack of specific granules in neutrophils.
http://purl.obolibrary.org/obo/HP_0012552	Increased neutrophil nuclear projections	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		Presence of an elevated number of projections from nuclei of neutrophils. These projections can have the shape of hooks, tags, or clubs.
http://purl.obolibrary.org/obo/HP_0012553	Hypoplastic thumbnail	http://purl.obolibrary.org/obo/HP_0001804	Hypoplastic fingernail		A thumbnail that is diminished in length and width, i.e., underdeveloped thumb nail.
http://purl.obolibrary.org/obo/HP_0012554	Absent thumbnail	http://purl.obolibrary.org/obo/HP_0001817	Absent fingernail		Absence of thumb nail.
http://purl.obolibrary.org/obo/HP_0012555	Absent nail of hallux	http://purl.obolibrary.org/obo/HP_0001802	Absent toenail		Absent nail of big toe.
http://purl.obolibrary.org/obo/HP_0012556	Hyperbeta-alaninemia	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Increased concentration of beta-alanine in the blood.
http://purl.obolibrary.org/obo/HP_0012557	EEG with centrotemporal focal spike waves	http://purl.obolibrary.org/obo/HP_0033721	EEG with centrotemporal epileptiform discharges		EEG with focal sharp transient waves in the centrotemporal region of the brain (also known as the central sulcus), i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.
http://purl.obolibrary.org/obo/HP_0012558	Abnormal T3/T4 ratio	http://purl.obolibrary.org/obo/HP_0031508	Abnormal circulating thyroid hormone concentration		A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that deviates from normal.
http://purl.obolibrary.org/obo/HP_0012559	Increased T3/T4 ratio	http://purl.obolibrary.org/obo/HP_0012558	Abnormal T3/T4 ratio		A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is higher than normal.
http://purl.obolibrary.org/obo/HP_0012560	Decreased T3/T4 ratio	http://purl.obolibrary.org/obo/HP_0012558	Abnormal T3/T4 ratio		A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is lower than normal.
http://purl.obolibrary.org/obo/HP_0012561	Unicuspid aortic valve	http://purl.obolibrary.org/obo/HP_0031567	Abnormal aortic valve cusp morphology		The presence of an aortic valve with one instead of the normal three cusps (flaps).
http://purl.obolibrary.org/obo/HP_0012562	Premature epimetaphyseal fusion in hand	http://purl.obolibrary.org/obo/HP_0010588	Premature epimetaphyseal fusion		Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the hand, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.
http://purl.obolibrary.org/obo/HP_0012563	Premature epimetaphyseal fusion in foot	http://purl.obolibrary.org/obo/HP_0010588	Premature epimetaphyseal fusion		Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the foot, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.
http://purl.obolibrary.org/obo/HP_0012564	Premature epimetaphyseal fusion in tibia	http://purl.obolibrary.org/obo/HP_0010588	Premature epimetaphyseal fusion		Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the tibia, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.
http://purl.obolibrary.org/obo/HP_0012565	Premature epimetaphyseal fusion in fibula	http://purl.obolibrary.org/obo/HP_0010588	Premature epimetaphyseal fusion		Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the fibula, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.
http://purl.obolibrary.org/obo/HP_0012566	Premature epimetaphyseal fusion in radius	http://purl.obolibrary.org/obo/HP_0010588	Premature epimetaphyseal fusion		Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the radius, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.
http://purl.obolibrary.org/obo/HP_0012567	Premature epimetaphyseal fusion in ulna	http://purl.obolibrary.org/obo/HP_0010588	Premature epimetaphyseal fusion		Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the ulna, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.
http://purl.obolibrary.org/obo/HP_0012568	Lower eyelid edema	http://purl.obolibrary.org/obo/HP_0100540	Palpebral edema		Edema in the region of the Lower eyelid.
http://purl.obolibrary.org/obo/HP_0012569	Delayed menarche	http://purl.obolibrary.org/obo/HP_0000823	Delayed puberty		First period after the age of 15 years.
http://purl.obolibrary.org/obo/HP_0012570	Synovial sarcoma	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		A type of mesenchymal tissue cell tumor that exhibits epithelial differentiation, which most frequently arises in the extremities.
http://purl.obolibrary.org/obo/HP_0012571	Ureter fissus	http://purl.obolibrary.org/obo/HP_0000073	Ureteral duplication		A partial duplication of the ureter where the duplicated ureters fuse to a single ureter before their insertion into the bladder.
http://purl.obolibrary.org/obo/HP_0012572	Ureter duplex	http://purl.obolibrary.org/obo/HP_0000073	Ureteral duplication		A complete duplication of the ureter, where the duplicated ureters have separate insertions into the bladder.
http://purl.obolibrary.org/obo/HP_0012573	Global proximal tubulopathy	http://purl.obolibrary.org/obo/HP_0000114	Proximal tubulopathy		A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption with bicarbonate loss and resulting acidosis.
http://purl.obolibrary.org/obo/HP_0012574	Mesangial hypercellularity	http://purl.obolibrary.org/obo/HP_0033231	Abnormal glomerular mesangial cellularity		Increased numbers of mesangial cells per glomerulus, defined as more than 3 nuclei fully surrounded by matrix in one or more mesangial areas, not including perihilar region, on a standard 3-micron-thick tissue section, best evaluated on periodic acid-Schiff (PAS) stain.
http://purl.obolibrary.org/obo/HP_0012576	Glomerular C3 deposition	http://purl.obolibrary.org/obo/HP_0030949	Glomerular deposits		The presence of complement 3 deposits in the glomerulus.
http://purl.obolibrary.org/obo/HP_0012577	Thin glomerular basement membrane	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Decreased thickness of the glomerular basement membrane (GBM), measured from endothelial to visceral epithelial plasma membrane and mainly attributable to a decrease in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations less than that of the normal mean GBM thickness for health age- and sex matched individuals. May be focal or diffuse, although the term thin GBMs generally implies thinning of over 50% of GBMs.
http://purl.obolibrary.org/obo/HP_0012578	Membranous nephropathy	http://purl.obolibrary.org/obo/HP_0000099	Glomerulonephritis		A type of glomerulonephropathy characterized by thickening of the basement membrane and deposition of immune complexes in the subepithelial space.
http://purl.obolibrary.org/obo/HP_0012579	Minimal change glomerulonephritis	http://purl.obolibrary.org/obo/HP_0000099	Glomerulonephritis		The presence of minimal changes visible by light microscopy but flattened and fused podocyte foot processes on electron microscopy in a person with nephrotic range proteinuria.
http://purl.obolibrary.org/obo/HP_0012580	Calcium phosphate nephrolithiasis	http://purl.obolibrary.org/obo/HP_0004724	Calcium nephrolithiasis		The presence of calcium- and phosphate-containing calculi (stones) in the kidneys.
http://purl.obolibrary.org/obo/HP_0012581	Simple renal cyst	http://purl.obolibrary.org/obo/HP_0000107	Renal cyst		An isolated cyst of the kidney.
http://purl.obolibrary.org/obo/HP_0012582	Bilateral renal dysplasia	http://purl.obolibrary.org/obo/HP_0000110	Renal dysplasia		A bilateral form of developmental dysplasia of the kidney.
http://purl.obolibrary.org/obo/HP_0012583	Unilateral renal hypoplasia	http://purl.obolibrary.org/obo/HP_0000089	Renal hypoplasia		One sided hypoplasia of the kidney.
http://purl.obolibrary.org/obo/HP_0012584	Bilateral renal hypoplasia	http://purl.obolibrary.org/obo/HP_0000089	Renal hypoplasia		Two sided hypoplasia of the kidney.
http://purl.obolibrary.org/obo/HP_0012586	Bilateral renal atrophy	http://purl.obolibrary.org/obo/HP_0012585	Renal atrophy		A two-sided form of atrophy of the kidney.
http://purl.obolibrary.org/obo/HP_0012587	Macroscopic hematuria	http://purl.obolibrary.org/obo/HP_0000790	Hematuria		Hematuria that is visible upon inspection of the urine.
http://purl.obolibrary.org/obo/HP_0012588	Steroid-resistant nephrotic syndrome	http://purl.obolibrary.org/obo/HP_0000100	Nephrotic syndrome		A form of nephrotic syndrome that does not respond to treatment with steroid medication, defined as persistent proteinuria despite 60mg/m2 or 2mg/kg for 8 weeks, after insuring no infection or non-adherence to medication.
http://purl.obolibrary.org/obo/HP_0012589	Multidrug-resistant nephrotic syndrome	http://purl.obolibrary.org/obo/HP_0000100	Nephrotic syndrome		A form of nephrotic syndrome that does not respond to any immunosuppresive treatment.
http://purl.obolibrary.org/obo/HP_0012592	Albuminuria	http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level		Increased concentration of albumin in the urine.
http://purl.obolibrary.org/obo/HP_0012593	Nephrotic range proteinuria	http://purl.obolibrary.org/obo/HP_0000093	Proteinuria		Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children.
http://purl.obolibrary.org/obo/HP_0012594	Moderate albuminuria	http://purl.obolibrary.org/obo/HP_0012592	Albuminuria		The presence of moderately increased concentrations of albumin in the urine, defined as and albumin-creatinine ratio (ACR) of 30 to 299 mg/gm (3.4 to 34 mg/mmol).
http://purl.obolibrary.org/obo/HP_0012595	Mild proteinuria	http://purl.obolibrary.org/obo/HP_0000093	Proteinuria		Mildly increased levels of protein in the urine (150-500 mg per day in adults).
http://purl.obolibrary.org/obo/HP_0012596	Moderate proteinuria	http://purl.obolibrary.org/obo/HP_0000093	Proteinuria		Moderately increased levels of protein in the urine (500-1000 mg per day in adults).
http://purl.obolibrary.org/obo/HP_0012597	Heavy proteinuria	http://purl.obolibrary.org/obo/HP_0000093	Proteinuria		Severely increased levels of protein in the urine (1000-3000 mg per day in adults).
http://purl.obolibrary.org/obo/HP_0012601	Hypochloriduria	http://purl.obolibrary.org/obo/HP_0012600	Abnormal urine chloride concentration		An decreased concentration of chloride in the urine.
http://purl.obolibrary.org/obo/HP_0012602	Renal chloride wasting	http://purl.obolibrary.org/obo/HP_0012600	Abnormal urine chloride concentration		High urine chloride in the presence of hypochloridemia.
http://purl.obolibrary.org/obo/HP_0012603	Abnormal urine sodium concentration	http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration		An abnormal concentration of sodium in the urine.
http://purl.obolibrary.org/obo/HP_0012604	Hyponatriuria	http://purl.obolibrary.org/obo/HP_0012603	Abnormal urine sodium concentration		An abnormally decreased sodium concentration in the urine.
http://purl.obolibrary.org/obo/HP_0012605	Hypernatriuria	http://purl.obolibrary.org/obo/HP_0012603	Abnormal urine sodium concentration		An increased concentration of sodium(1+) in the urine.
http://purl.obolibrary.org/obo/HP_0012606	Renal sodium wasting	http://purl.obolibrary.org/obo/HP_0012603	Abnormal urine sodium concentration		An abnormally increased sodium concentration in the urine in the presence of hyponatremia.
http://purl.obolibrary.org/obo/HP_0012607	Abnormal urine magnesium concentration	http://purl.obolibrary.org/obo/HP_0012591	Abnormal urinary electrolyte concentration		An abnormal concentration of magnesium the urine.
http://purl.obolibrary.org/obo/HP_0012608	Hypermagnesiuria	http://purl.obolibrary.org/obo/HP_0012607	Abnormal urine magnesium concentration		An increased concentration of magnesium the urine.
http://purl.obolibrary.org/obo/HP_0012609	Hypomagnesiuria	http://purl.obolibrary.org/obo/HP_0012607	Abnormal urine magnesium concentration		An decreased concentration of magnesium the urine.
http://purl.obolibrary.org/obo/HP_0012610	Abnormality of urinary uric acid level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		Abnormal amount of urate in the urine.
http://purl.obolibrary.org/obo/HP_0012613	Increased urinary sulfate	http://purl.obolibrary.org/obo/HP_0012612	Abnormal urinary sulfate concentration		Elevated concentration of SO4(2-), i.e., sulfate, in the urine.
http://purl.obolibrary.org/obo/HP_0012615	Cylindruria	http://purl.obolibrary.org/obo/HP_0012614	Abnormal urine cytology		The presence of renal casts (cylindrical, cigar-shaped structures produced by the kidney in certain disease states) in the urine.
http://purl.obolibrary.org/obo/HP_0012616	Leukocyte cylindruria	http://purl.obolibrary.org/obo/HP_0031197	Cellular urinary casts		Presence of leukocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine.
http://purl.obolibrary.org/obo/HP_0012617	Erythrocyte cylindruria	http://purl.obolibrary.org/obo/HP_0031197	Cellular urinary casts		Presence of erythrocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine.
http://purl.obolibrary.org/obo/HP_0012618	Urachal cyst	http://purl.obolibrary.org/obo/HP_0010478	Abnormality of the urachus		A cyst located along the allantois canal.
http://purl.obolibrary.org/obo/HP_0012619	Multiple bladder diverticula	http://purl.obolibrary.org/obo/HP_0000015	Bladder diverticulum		Presence of a many diverticula (sac or pouch) in the wall of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0012620	Cloacal abnormality	http://purl.obolibrary.org/obo/HP_0010866	Abdominal wall defect		A developmental anomaly associated with the failure of rectum, vagina, and bladder to separate.
http://purl.obolibrary.org/obo/HP_0012621	Persistent cloaca	http://purl.obolibrary.org/obo/HP_0012620	Cloacal abnormality		Developmental anomaly in which the vagina, bladder, and rectum fuse resulting in a common channel.
http://purl.obolibrary.org/obo/HP_0012623	Stage 1 chronic kidney disease	http://purl.obolibrary.org/obo/HP_0012622	Chronic kidney disease		A type of chronic kidney disease with normal or increased glomerular filtration rate (GFR at least 90 mL/min/1.73 m2).
http://purl.obolibrary.org/obo/HP_0012624	Stage 2 chronic kidney disease	http://purl.obolibrary.org/obo/HP_0012622	Chronic kidney disease		A type of chronic kidney disease with mildly reduced glomerular filtration rate (GFR 60-89 mL/min/1.73 m2).
http://purl.obolibrary.org/obo/HP_0012625	Stage 3 chronic kidney disease	http://purl.obolibrary.org/obo/HP_0012622	Chronic kidney disease		A type of chronic kidney disease with moderately reduced glomerular filtration rate (GFR 30-59 mL/min/1.73 m2).
http://purl.obolibrary.org/obo/HP_0012626	Stage 4 chronic kidney disease	http://purl.obolibrary.org/obo/HP_0012622	Chronic kidney disease		A type of chronic kidney disease with severely reduced glomerular filtration rate (GFR 15-29 mL/min/1.73 m2).
http://purl.obolibrary.org/obo/HP_0012627	Pseudoexfoliation	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		Deposition of fibrillar material that can be found on all anterior segment structures bathed by aqueous humor.
http://purl.obolibrary.org/obo/HP_0012628	Abnormal suspensory ligament of lens morphology	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		An anomaly of the suspensory ligament of lens, also known as the ciliary zonule. These ligaments represent a series of fibers connecting the ciliary body and lens of the eye, holding the lens in place.
http://purl.obolibrary.org/obo/HP_0012629	Phakodonesis	http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology		Tremulousness (trembling) of the lens of the eye.
http://purl.obolibrary.org/obo/HP_0012630	Abnormal trabecular meshwork morphology	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		An anomaly of the trabecular meshwork, which is the porelike structure surrounding the entire circumference of the anterior chamber at the base of the cornea and near the ciliary body. The trabecular mesh work is responsible for draining the aqueous humor into the canal of Schlemm.
http://purl.obolibrary.org/obo/HP_0012631	Pigment deposition in the trabecular meshwork	http://purl.obolibrary.org/obo/HP_0012630	Abnormal trabecular meshwork morphology		Accumulation of abnormal amounts of pigment within the trabecular meshwork.
http://purl.obolibrary.org/obo/HP_0012632	Abnormal intraocular pressure	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		An anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye.
http://purl.obolibrary.org/obo/HP_0012633	Asymmetry of intraocular pressure	http://purl.obolibrary.org/obo/HP_0012632	Abnormal intraocular pressure		A difference in the amount of intraocular pressure in the right and left eye.
http://purl.obolibrary.org/obo/HP_0012634	Iris pigment dispersion	http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation		Shedding of the pigment granules that normally adhere to the back of the iris into the aqueous humor.
http://purl.obolibrary.org/obo/HP_0012635	Iris hypoperfusion	http://purl.obolibrary.org/obo/HP_0007905	Abnormal iris vasculature		Reduction in the amount of blood flow to the iris.
http://purl.obolibrary.org/obo/HP_0012636	Retinal venous occlusion	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		Blockage of a retinal vein or venule, occurring typically at an arteriovenous crossing. Typically presenting with dilated veins, retinal hemorrhages and in some cases non-perfusion.
http://purl.obolibrary.org/obo/HP_0012637	Renal calcium wasting	http://purl.obolibrary.org/obo/HP_0011280	Abnormality of urine calcium concentration		High urine calcium in the presence of hypocalcemia.
http://purl.obolibrary.org/obo/HP_0012641	Decreased intracranial pressure	http://purl.obolibrary.org/obo/HP_0012640	Abnormality of intracranial pressure		A reduction of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0012642	Cerebellar agenesis	http://purl.obolibrary.org/obo/HP_0007360	Aplasia/Hypoplasia of the cerebellum		Cerebellar agenesis is defined by the near complete absence of cerebellar tissue with only remnants of the anterior vermis, flocculus, and/or middle cerebellar peduncles.
http://purl.obolibrary.org/obo/HP_0012643	Foveal hypopigmentation	http://purl.obolibrary.org/obo/HP_0030493	Abnormal foveal pigmentation		Decreased amount of pigmentation in the fovea.
http://purl.obolibrary.org/obo/HP_0012644	Increased caudate lactate level	http://purl.obolibrary.org/obo/HP_0002339	Abnormal caudate nucleus morphology		An elevated concentration of lactate in the caudate nucleus. This finding can be elicited by magnetic resonance spectroscopy imaging.
http://purl.obolibrary.org/obo/HP_0012645	Enlarged peripheral nerve	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Increase in size of a peripheral nerve. This finding can be appreciated by palpation along the axis of the nerve.
http://purl.obolibrary.org/obo/HP_0012646	Retractile testis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		A testis that is located at the upper scrotum or lower inguinal canal and that can be made to descend completely into the scrotum without resistance by manual reduction but returns to its original position by the cremasteric reflex.
http://purl.obolibrary.org/obo/HP_0012647	Abnormal inflammatory response	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
http://purl.obolibrary.org/obo/HP_0012648	Decreased inflammatory response	http://purl.obolibrary.org/obo/HP_0012647	Abnormal inflammatory response		An abnormal reduction in the inflammatory response to injury or infection.
http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response	http://purl.obolibrary.org/obo/HP_0012647	Abnormal inflammatory response		A abnormal increase in the inflammatory response to injury or infection.
http://purl.obolibrary.org/obo/HP_0012650	Perisylvian polymicrogyria	http://purl.obolibrary.org/obo/HP_0002126	Polymicrogyria		Polymicrogyria (an excessive number of small gyri or convolutions) that is maximal in perisylvian regions (the regions that surround the Sylvian fissures), which may be symmetric or asymmetric and may extend beyond perisylvian regions. The Sylvian fissures often extend posteriorly and superiorly.
http://purl.obolibrary.org/obo/HP_0012651	Abasia	http://purl.obolibrary.org/obo/HP_0002066	Gait ataxia		A severe form of gait ataxia such that an affected person cannot walk at all.
http://purl.obolibrary.org/obo/HP_0012652	Exercise-induced asthma	http://purl.obolibrary.org/obo/HP_0002099	Asthma		Asthma attacks following exercise.
http://purl.obolibrary.org/obo/HP_0012653	Status asthmaticus	http://purl.obolibrary.org/obo/HP_0002099	Asthma		Severe asthma unresponsive to repeated courses of beta-agonist therapy such as inhaled albuterol, levalbuterol, or subcutaneous epinephrine.
http://purl.obolibrary.org/obo/HP_0012654	Abnormal CSF dopamine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Abnormal concentration of dopamine in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0012655	Elevated CSF dopamine concentration	http://purl.obolibrary.org/obo/HP_0012654	Abnormal CSF dopamine concentration		Increased concentration of dopamine in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0012656	Reduced CSF dopamine concentration	http://purl.obolibrary.org/obo/HP_0012654	Abnormal CSF dopamine concentration		Decreased concentration of dopamine in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0012657	Abnormal brain positron emission tomography	http://purl.obolibrary.org/obo/HP_0410263	Brain imaging abnormality		A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain.
http://purl.obolibrary.org/obo/HP_0012658	Abnormal brain FDG positron emission tomography	http://purl.obolibrary.org/obo/HP_0012657	Abnormal brain positron emission tomography		An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity.
http://purl.obolibrary.org/obo/HP_0012659	Prefrontal hypometabolism in FDG PET	http://purl.obolibrary.org/obo/HP_0012658	Abnormal brain FDG positron emission tomography		Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the prefrontal cortex as measured by positron emission tomography (PET) brain scan.
http://purl.obolibrary.org/obo/HP_0012660	Thalamic hypometabolism in FDG PET	http://purl.obolibrary.org/obo/HP_0012658	Abnormal brain FDG positron emission tomography		Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan.
http://purl.obolibrary.org/obo/HP_0012661	Hypothalamic hypometabolism in FDG PET	http://purl.obolibrary.org/obo/HP_0012658	Abnormal brain FDG positron emission tomography		Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan.
http://purl.obolibrary.org/obo/HP_0012662	Parietal hypometabolism in FDG PET	http://purl.obolibrary.org/obo/HP_0012658	Abnormal brain FDG positron emission tomography		Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the parietal cortex as measured by positron emission tomography (PET) brain scan.
http://purl.obolibrary.org/obo/HP_0012663	Mildly reduced left ventricular ejection fraction	http://purl.obolibrary.org/obo/HP_0012664	Reduced left ventricular ejection fraction		A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent.
http://purl.obolibrary.org/obo/HP_0012664	Reduced left ventricular ejection fraction	http://purl.obolibrary.org/obo/HP_0025169	Left ventricular systolic dysfunction		A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle.
http://purl.obolibrary.org/obo/HP_0012665	Moderately reduced left ventricular ejection fraction	http://purl.obolibrary.org/obo/HP_0012664	Reduced left ventricular ejection fraction		A medium reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle, defined as a left ventricular ejection fraction of 30-39 percent.
http://purl.obolibrary.org/obo/HP_0012666	Severely reduced left ventricular ejection fraction	http://purl.obolibrary.org/obo/HP_0012664	Reduced left ventricular ejection fraction		A large reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at over 50 percent, and a severe reduction is defined as less than 30 percent.
http://purl.obolibrary.org/obo/HP_0012667	Regional left ventricular wall motion abnormality	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		An abnormal motion of a segment of the left ventricle during the cardiac cycle.
http://purl.obolibrary.org/obo/HP_0012668	Vasovagal syncope	http://purl.obolibrary.org/obo/HP_0001279	Syncope		A vasovagal episode or vasovagal syncope is the most common form of reflex syncope. Reflex syncope is a general term used to describe types of syncope resulting from a failure in autoregulation of blood pressure, and ultimately, in cerebral perfusion pressure resulting in transient loss of consciousness. The mechanisms responsible for this are complex and involve both depression of cardiac output as well as a decrease in vascular tone.
http://purl.obolibrary.org/obo/HP_0012669	Carotid sinus syncope	http://purl.obolibrary.org/obo/HP_0001279	Syncope		An exaggerated response to carotid sinus baroreceptor stimulation resulting in syncope from transient diminished cerebral perfusion.
http://purl.obolibrary.org/obo/HP_0012670	Orthostatic syncope	http://purl.obolibrary.org/obo/HP_0001279	Syncope		Syncope following a quick change in position from lying down to standing.
http://purl.obolibrary.org/obo/HP_0012671	Abulia	http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition		Abulia is characterized by difficulty in initiating and sustaining spontaneous movements; the person often appears frozen but will move hesitantly on request. There are frequently substantial reductions in emotional responsiveness, spontaneous speech, and social interaction. The individual appears to be content to remain still and inactive with minimal movement, but moves or reacts hesitantly in response to interactions.
http://purl.obolibrary.org/obo/HP_0012672	Akinetic mutism	http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition		The combined absence of spontaneous movement (akinesia) and speech (mutism). There may be eye movements consistent with visual tracking and the person may remember the events occurring at the time of the experience of stupor.
http://purl.obolibrary.org/obo/HP_0012673	Aplasia of the upper vagina	http://purl.obolibrary.org/obo/HP_0003250	Aplasia of the vagina		A failure to develop of the upper vagina.
http://purl.obolibrary.org/obo/HP_0012674	Aplasia of the lower vagina	http://purl.obolibrary.org/obo/HP_0003250	Aplasia of the vagina		A failure to develop of the lower part of the vagina.
http://purl.obolibrary.org/obo/HP_0012675	Iron accumulation in brain	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		An abnormal build up of iron (Fe) in brain tissue.
http://purl.obolibrary.org/obo/HP_0012676	Copper accumulation in brain	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		An anomalous build up of copper (Cu) in the brain.
http://purl.obolibrary.org/obo/HP_0012678	Iron accumulation in substantia nigra	http://purl.obolibrary.org/obo/HP_0012675	Iron accumulation in brain		An anomalous build up of iron (Fe) in the substantia nigra.
http://purl.obolibrary.org/obo/HP_0012679	Widened interpedicular distance	http://purl.obolibrary.org/obo/HP_0008438	Vertebral arch anomaly		An increase in the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces.
http://purl.obolibrary.org/obo/HP_0012680	Abnormality of the pineal gland	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		An anomaly of the pineal gland,a small endocrine gland in the brain that produces melatonin.
http://purl.obolibrary.org/obo/HP_0012681	Abnormal pineal morphology	http://purl.obolibrary.org/obo/HP_0012680	Abnormality of the pineal gland		A structural abnormality of the pineal gland.
http://purl.obolibrary.org/obo/HP_0012682	Pineal gland calcification	http://purl.obolibrary.org/obo/HP_0012681	Abnormal pineal morphology		Accumulation of calcium salts in the pineal gland.
http://purl.obolibrary.org/obo/HP_0012683	Pineal cyst	http://purl.obolibrary.org/obo/HP_0012681	Abnormal pineal morphology		A glial uniloculated or multiloculated fluid-filled sac that either reside within or completely replace the pineal gland.
http://purl.obolibrary.org/obo/HP_0012684	Abnormal pineal volume	http://purl.obolibrary.org/obo/HP_0012681	Abnormal pineal morphology		An abnormal increase or decrease in the quantity of three-dimensional space taken up by the pineal gland.
http://purl.obolibrary.org/obo/HP_0012685	Decreased pineal volume	http://purl.obolibrary.org/obo/HP_0012684	Abnormal pineal volume		An abnormal reduction in the quantity of three-dimensional space taken up by the pineal gland.
http://purl.obolibrary.org/obo/HP_0012686	Increased pineal volume	http://purl.obolibrary.org/obo/HP_0012684	Abnormal pineal volume		An abnormal elevation in the quantity of three-dimensional space taken up by the pineal gland.
http://purl.obolibrary.org/obo/HP_0012687	Agenesis of pineal gland	http://purl.obolibrary.org/obo/HP_0012681	Abnormal pineal morphology		Failure to develop of the pineal gland, defined clinically as the absence of the pineal gland with no indication of the pineal gland even having been present.
http://purl.obolibrary.org/obo/HP_0012688	Abnormality of pineal physiology	http://purl.obolibrary.org/obo/HP_0012680	Abnormality of the pineal gland		A functional abnormality of the pineal gland.
http://purl.obolibrary.org/obo/HP_0012689	Abnormal pineal melatonin secretion	http://purl.obolibrary.org/obo/HP_0012688	Abnormality of pineal physiology		An anomaly in the amount or timing of melatonin secretion by the pineal gland. Note that melatonin is also synthesized by multiple tissues outside of the pineal gland.
http://purl.obolibrary.org/obo/HP_0012690	T2 hypointense thalamus	http://purl.obolibrary.org/obo/HP_0012696	Abnormal thalamic MRI signal intensity		A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a diffuse hypointensity affecting the entire thalamus.
http://purl.obolibrary.org/obo/HP_0012691	Focal T2 hypointense thalamic lesion	http://purl.obolibrary.org/obo/HP_0012696	Abnormal thalamic MRI signal intensity		A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hypointensity affecting a particular region of the thalamus.
http://purl.obolibrary.org/obo/HP_0012692	Focal T2 hyperintense thalamic lesion	http://purl.obolibrary.org/obo/HP_0012696	Abnormal thalamic MRI signal intensity		A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hyperintensity affecting a particular region of the thalamus.
http://purl.obolibrary.org/obo/HP_0012693	Abnormal thalamic size	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		Deviation from the normal range of size of the thalamus.
http://purl.obolibrary.org/obo/HP_0012694	Enlarged thalamic volume	http://purl.obolibrary.org/obo/HP_0012693	Abnormal thalamic size		An increase in the quantity of space occupied by the thalamus.
http://purl.obolibrary.org/obo/HP_0012695	Decreased thalamic volume	http://purl.obolibrary.org/obo/HP_0012693	Abnormal thalamic size		A reduction in the quantity of space occupied by the thalamus.
http://purl.obolibrary.org/obo/HP_0012696	Abnormal thalamic MRI signal intensity	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		A deviation from normal signal on magnetic resonance imaging (MRI) of the thalamus.
http://purl.obolibrary.org/obo/HP_0012697	Small basal ganglia	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		Decreased size of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0012698	Cerebellar gliosis	http://purl.obolibrary.org/obo/HP_0002171	Gliosis		Focal proliferation of glial cells in the cerebellum.
http://purl.obolibrary.org/obo/HP_0012699	Anomaly of lower limb diaphyses	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		A structural abnormality of a diaphysis of the leg.
http://purl.obolibrary.org/obo/HP_0012701	Bowel urgency	http://purl.obolibrary.org/obo/HP_0012700	Abnormal large intestine physiology		A sudden, irresistible need to have a bowel movement.
http://purl.obolibrary.org/obo/HP_0012702	Tenesmus	http://purl.obolibrary.org/obo/HP_0012700	Abnormal large intestine physiology		A repeated, painful urge to defecate without excreting stool.
http://purl.obolibrary.org/obo/HP_0012704	Widened subarachnoid space	http://purl.obolibrary.org/obo/HP_0012703	Abnormal subarachnoid space morphology		An increase in size of the anatomic space between the arachnoid membrane and pia mater.
http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS	http://purl.obolibrary.org/obo/HP_0410263	Brain imaging abnormality		An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0012706	Elevated brain choline level by MRS	http://purl.obolibrary.org/obo/HP_0025047	Abnormal brain choline level by MRS		An increase in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0012707	Elevated brain lactate level by MRS	http://purl.obolibrary.org/obo/HP_0025045	Abnormal brain lactate level by MRS		An increase in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0012708	Reduced brain N-acetyl aspartate level by MRS	http://purl.obolibrary.org/obo/HP_0025052	Abnormal brain N-acetyl aspartate level by MRS		A decrease in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0012709	Abnormal brain choline/creatine ratio by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		A deviation from normal in the ratio of choline to creatine in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0012710	Ingrown nail	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Excessive growth of a nail laterally into the nail fold.
http://purl.obolibrary.org/obo/HP_0012711	Delayed ossification of vertebral epiphysis	http://purl.obolibrary.org/obo/HP_0100569	Abnormally ossified vertebrae		A delay in the process of formation and maturation of the epiphysis of one or more vertebrae.
http://purl.obolibrary.org/obo/HP_0012712	Mild hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		The presence of a mild form of hearing impairment.
http://purl.obolibrary.org/obo/HP_0012713	Moderate hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		The presence of a moderate form of hearing impairment.
http://purl.obolibrary.org/obo/HP_0012714	Severe hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A severe form of hearing impairment.
http://purl.obolibrary.org/obo/HP_0012715	Profound hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A profound (essentially complete) form of hearing impairment.
http://purl.obolibrary.org/obo/HP_0012716	Moderate conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0012713	Moderate hearing impairment		The presence of a moderate form of conductive hearing impairment.
http://purl.obolibrary.org/obo/HP_0012717	Severe conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0012714	Severe hearing impairment		A severe form of conductive hearing impairment.
http://purl.obolibrary.org/obo/HP_0012720	Neoplasm of the nose	http://purl.obolibrary.org/obo/HP_0100630	Neoplasia of the nasopharynx		Tumor (An abnormal mass of tissue resulting from abnormally dividing cells) of the nasal cavity.
http://purl.obolibrary.org/obo/HP_0012721	Venous malformation	http://purl.obolibrary.org/obo/HP_0002624	Abnormal venous morphology		A vascular malformation resulting from a developmental error of venous tissue composed of dysmorphic channels lined by flattened endothelium and exhibiting slow turnover. A venous malformation may present as a blue patch on the skin ranging to a soft blue mass. Venous malformations are easily compressible and usually swell in thewhen venous pressure increases (e.g., when held in a dependent position or when a child cries). They may be relatively localized or quite extensive within an anatomic region.
http://purl.obolibrary.org/obo/HP_0012723	Sinoatrial block	http://purl.obolibrary.org/obo/HP_0012722	Heart block		Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria.
http://purl.obolibrary.org/obo/HP_0012724	Upper eyelid edema	http://purl.obolibrary.org/obo/HP_0100540	Palpebral edema		Edema in the region of the upper eyelid.
http://purl.obolibrary.org/obo/HP_0012725	Cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0001159	Syndactyly		A soft tissue continuity in the A/P axis between two digits that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two digits that lies significantly distal to the flexion crease that overlies the metacarpophalangeal or metatarsophalangeal joint of the adjacent digits.
http://purl.obolibrary.org/obo/HP_0012726	Episodic hypokalemia	http://purl.obolibrary.org/obo/HP_0002900	Hypokalemia		An abnormally decreased potassium concentration in the blood occurring periodically with a return to normal between the episodes.
http://purl.obolibrary.org/obo/HP_0012728	Fusiform descending thoracic aortic aneurysm	http://purl.obolibrary.org/obo/HP_0004959	Descending thoracic aorta aneurysm		A concentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves the full circumference of the vessel wall
http://purl.obolibrary.org/obo/HP_0012729	Saccular descending thoracic aortic aneurysm	http://purl.obolibrary.org/obo/HP_0004959	Descending thoracic aorta aneurysm		An eccentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves only a portion of the circumference of the vessel wall
http://purl.obolibrary.org/obo/HP_0012730	Aglossia	http://purl.obolibrary.org/obo/HP_0010295	Aplasia/Hypoplasia of the tongue		Absence of the tongue owing to a developmental abnormality.
http://purl.obolibrary.org/obo/HP_0012731	Ectopic anterior pituitary gland	http://purl.obolibrary.org/obo/HP_0011747	Abnormality of the anterior pituitary		Abnormal anatomic location of the anterior pituitary gland.
http://purl.obolibrary.org/obo/HP_0012734	Ketotic hypoglycemia	http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia		Low blood glucose is accompanied by elevated levels of ketone bodies in the body.
http://purl.obolibrary.org/obo/HP_0012735	Cough	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
http://purl.obolibrary.org/obo/HP_0012736	Profound global developmental delay	http://purl.obolibrary.org/obo/HP_0001263	Global developmental delay		A profound delay in the achievement of motor or mental milestones in the domains of development of a child.
http://purl.obolibrary.org/obo/HP_0012737	Small intestinal polyp	http://purl.obolibrary.org/obo/HP_0100833	Neoplasm of the small intestine		A discrete abnormal tissue mass that protrudes into the lumen of the small intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base.
http://purl.obolibrary.org/obo/HP_0012738	Agenesis of canine	http://purl.obolibrary.org/obo/HP_0011078	Abnormality of canine		Agenesis of canine tooth.
http://purl.obolibrary.org/obo/HP_0012739	Agenesis of the small intestine	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		Failure to develop of the small intestine.
http://purl.obolibrary.org/obo/HP_0012740	Papilloma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		A tumor of the skin or mucous membrane with finger-like projections.
http://purl.obolibrary.org/obo/HP_0012741	Unilateral cryptorchidism	http://purl.obolibrary.org/obo/HP_0000028	Cryptorchidism		Absence of a testis from the scrotum on one side owing to failure of the testis or testes to descend through the inguinal canal to the scrotum.
http://purl.obolibrary.org/obo/HP_0012742	Thin fingernail	http://purl.obolibrary.org/obo/HP_0001816	Thin nail		Fingernail that appears thin when viewed on end.
http://purl.obolibrary.org/obo/HP_0012743	Abdominal obesity	http://purl.obolibrary.org/obo/HP_0001513	Obesity		Excessive fat around the stomach and abdomen.
http://purl.obolibrary.org/obo/HP_0012744	Femoral aplasia	http://purl.obolibrary.org/obo/HP_0005613	Aplasia/hypoplasia of the femur		Failure of the femur to develop.
http://purl.obolibrary.org/obo/HP_0012745	Short palpebral fissure	http://purl.obolibrary.org/obo/HP_0200007	Abnormal size of the palpebral fissures		Distance between the medial and lateral canthi is more than 2 SD below the mean for age (objective); or, apparently reduced length of the palpebral fissures.
http://purl.obolibrary.org/obo/HP_0012746	Thin toenail	http://purl.obolibrary.org/obo/HP_0008388	Abnormal toenail morphology		Toenail that appears thin when viewed on end.
http://purl.obolibrary.org/obo/HP_0012747	Abnormal brainstem MRI signal intensity	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		A deviation from normal signal on magnetic resonance imaging (MRI) of the brainstem.
http://purl.obolibrary.org/obo/HP_0012748	Focal T2 hyperintense brainstem lesion	http://purl.obolibrary.org/obo/HP_0012747	Abnormal brainstem MRI signal intensity		A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hyperintensity affecting a particular region of the brainstem.
http://purl.obolibrary.org/obo/HP_0012749	Focal T2 hypointense brainstem lesion	http://purl.obolibrary.org/obo/HP_0012747	Abnormal brainstem MRI signal intensity		A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hypointensity affecting a particular region of the brainstem.
http://purl.obolibrary.org/obo/HP_0012750	T2 hypointense brainstem	http://purl.obolibrary.org/obo/HP_0012747	Abnormal brainstem MRI signal intensity		A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a diffuse hypointensity affecting the entire brainstem.
http://purl.obolibrary.org/obo/HP_0012751	Abnormal basal ganglia MRI signal intensity	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		A deviation from normal signal on magnetic resonance imaging (MRI) of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0012752	Focal T2 hypointense basal ganglia lesion	http://purl.obolibrary.org/obo/HP_0012751	Abnormal basal ganglia MRI signal intensity		A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hypointensity affecting a particular region of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0012753	T2 hypointense basal ganglia	http://purl.obolibrary.org/obo/HP_0012751	Abnormal basal ganglia MRI signal intensity		A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a diffuse hypointensity affecting all of the basal ganglia.
http://purl.obolibrary.org/obo/HP_0012754	CNS hypermyelination	http://purl.obolibrary.org/obo/HP_0011400	Abnormal CNS myelination		Increased amount of myelin in the central nervous system.
http://purl.obolibrary.org/obo/HP_0012755	Enlarged brainstem	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		Abnormal increase in size of the brainstem.
http://purl.obolibrary.org/obo/HP_0100001	Malignant mesothelioma	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		Malignant mesothelioma is a form of cancer that originates from the cells of the mesothelium, a thin tissue layer surrounding the body's internal organs. Malignant mesothelioma is almost exclusively caused by asbestos exposure, pleural mesothelioma being the most common form, affecting the lining of the lungs called the pleura. Other forms such as perioneal-, percardial- or testicular- mesothelioma are much rarer.
http://purl.obolibrary.org/obo/HP_0100002	Pleural mesothelioma	http://purl.obolibrary.org/obo/HP_0100527	Neoplasia of the pleura		A malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma.
http://purl.obolibrary.org/obo/HP_0100003	Peritoneal mesothelioma	http://purl.obolibrary.org/obo/HP_0100016	Abnormal mesentery morphology		A Malignant mesothelioma originating from cells of the peritoneum (the thin layer of mesothelium lining the abdomen). Peritoneal mesothelioma is the second most common form of mesothelioma after pleural mesothelioma.
http://purl.obolibrary.org/obo/HP_0100004	Pericardial mesothelioma	http://purl.obolibrary.org/obo/HP_0100001	Malignant mesothelioma		A Malignant mesothelioma originating from cells of the pericardium (the thin layer of mesothelium lining the heart).
http://purl.obolibrary.org/obo/HP_0100005	Testicular mesothelioma	http://purl.obolibrary.org/obo/HP_0100001	Malignant mesothelioma		A Malignant mesothelioma of the testis.
http://purl.obolibrary.org/obo/HP_0100006	Neoplasm of the central nervous system	http://purl.obolibrary.org/obo/HP_0004375	Neoplasm of the nervous system		A neoplasm of the central nervous system.
http://purl.obolibrary.org/obo/HP_0100008	Schwannoma	http://purl.obolibrary.org/obo/HP_0100007	Neoplasm of the peripheral nervous system		A benign nerve sheath tumor composed of Schwann cells.
http://purl.obolibrary.org/obo/HP_0100012	Neoplasm of the eye	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		A tumor (abnormal growth of tissue) of the eye.
http://purl.obolibrary.org/obo/HP_0100014	Epiretinal membrane	http://purl.obolibrary.org/obo/HP_0030498	Macular thickening		An epiretinal membrane is a thin sheet of fibrous tissue on the surface of the retina along the inner limiting membrane. It appears as a greyish semi-translucent avascular membrane over the internal limiting membrane (ILM) on the surface of the retina.
http://purl.obolibrary.org/obo/HP_0100015	Stahl ear	http://purl.obolibrary.org/obo/HP_0011235	Additional crus of antihelix		The presence of a supernumerary, i.e. third, crus of the helix in the helix, arising at or above the normal bifurcation of the antihelix.
http://purl.obolibrary.org/obo/HP_0100016	Abnormal mesentery morphology	http://purl.obolibrary.org/obo/HP_0002012	Abnormality of the abdominal organs		Folds of membranous tissue (peritoneum, mesothelium) attached to the wall of the abdomen and enclosing viscera. Examples include the mesentery for the small intestine; the transverse mesocolon, which attaches the transverse portion of the colon to the back wall of the abdomen; and the mesosigmoid, which enfolds the sigmoid portion of the colon. Cells of the same embryologic origin also surround the other organs of the body such as the lungs (pleura) or the heart (pericardium).
http://purl.obolibrary.org/obo/HP_0100017	Capsular cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A cataract that affects the capsule of the lens.
http://purl.obolibrary.org/obo/HP_0100018	Nuclear cataract	http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract		A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown.
http://purl.obolibrary.org/obo/HP_0100019	Cortical cataract	http://purl.obolibrary.org/obo/HP_0010920	Zonular cataract		A cataract which affects the layer of the lens surrounding the nucleus, i.e., the lens cortex. It is identified by its unique wedge or spoke appearance.
http://purl.obolibrary.org/obo/HP_0100020	Posterior capsular cataract	http://purl.obolibrary.org/obo/HP_0100017	Capsular cataract		A cataract which is found in the back outer layer of the lens. This type often develops more rapidly.
http://purl.obolibrary.org/obo/HP_0100023	Recurrent hand flapping	http://purl.obolibrary.org/obo/HP_5200018	Stereotypic upper-extremity movements		A type of repetitive behavior in which the affected individual repeatedly waves the hands and/or arms rhythmically.
http://purl.obolibrary.org/obo/HP_0100024	Conspicuously happy disposition	http://purl.obolibrary.org/obo/HP_0040082	Happy demeanor		An unusually happy demeanor over time, which can also be observed during inappropriate situations that should, for example, cause distress, fear, or anger.
http://purl.obolibrary.org/obo/HP_0100025	Overfriendliness	http://purl.obolibrary.org/obo/HP_5200029	Social disinhibition		A form of hypersociability that presents as mostly inappropriate friendliness towards others.
http://purl.obolibrary.org/obo/HP_0100027	Recurrent pancreatitis	http://purl.obolibrary.org/obo/HP_0001733	Pancreatitis		A recurrent form of pancreatitis.
http://purl.obolibrary.org/obo/HP_0100028	Ectopic thyroid	http://purl.obolibrary.org/obo/HP_0008188	Thyroid dysgenesis		Mislocalised thyroid gland.
http://purl.obolibrary.org/obo/HP_0100029	Lingual thyroid	http://purl.obolibrary.org/obo/HP_0100028	Ectopic thyroid		An aberrant thyroid gland or Ectopic thyroid located at the base of the tongue, just posterior to the foramen cecum as a result of a failure of the thyroid to descend.
http://purl.obolibrary.org/obo/HP_0100030	Accessory ectopic thyroid tissue	http://purl.obolibrary.org/obo/HP_0100028	Ectopic thyroid		Accessory ectopic thyroid tissue arising from remnants of the thyroglossal duct anywhere along the path of the thyroglossal duct tract.
http://purl.obolibrary.org/obo/HP_0100033	Tics	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		Repeated, individually recognizable, intermittent movements or movement fragments that are almost always briefly suppressible and are usually associated with awareness of an urge to perform the movement.
http://purl.obolibrary.org/obo/HP_0100036	Pseudo-fractures	http://purl.obolibrary.org/obo/HP_0003103	Abnormal cortical bone morphology		A band of bone material of decreased density forming alongside the surface of the cortical bone with thickening of the periosteum. Callus formation in the affected area is common and gives the appearance of a false fracture.
http://purl.obolibrary.org/obo/HP_0100038	Slow-growing scalp hair	http://purl.obolibrary.org/obo/HP_0100037	Abnormality of the scalp hair		Scalp hair whose growth is slower than normal.
http://purl.obolibrary.org/obo/HP_0100040	Broad 2nd toe	http://purl.obolibrary.org/obo/HP_0010319	Abnormal second toe morphology		A broad appearance of the second toe.
http://purl.obolibrary.org/obo/HP_0100041	Broad 3rd toe	http://purl.obolibrary.org/obo/HP_0010320	Abnormal third toe morphology		A broad appearance of the third toe.
http://purl.obolibrary.org/obo/HP_0100042	Broad 4th toe	http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology		A broad appearance of the fourth toe.
http://purl.obolibrary.org/obo/HP_0100043	Broad 5th toe	http://purl.obolibrary.org/obo/HP_0010322	Abnormal fifth toe morphology		A broad appearance of the fifth toe.
http://purl.obolibrary.org/obo/HP_0100050	Ivory epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		Epiphyses of the 2nd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0100053	Stippling of the epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0100061	Ivory epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		Epiphyses of the 3rd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0100064	Stippling of the epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd toe.
http://purl.obolibrary.org/obo/HP_0100072	Ivory epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		Epiphyses of the 4th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0100075	Stippling of the epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th toe.
http://purl.obolibrary.org/obo/HP_0100083	Ivory epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		Epiphyses of the 5th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.
http://purl.obolibrary.org/obo/HP_0100086	Stippling of the epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100109	Stippling of the epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0100118	Pseudoepiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the second toe.
http://purl.obolibrary.org/obo/HP_0100120	Stippling of the epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0100129	Pseudoepiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the second toe.
http://purl.obolibrary.org/obo/HP_0100131	Stippling of the epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 2nd toe.
http://purl.obolibrary.org/obo/HP_0100144	Stippling of the epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 3rd toe.
http://purl.obolibrary.org/obo/HP_0100155	Stippling of the epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 3rd toe.
http://purl.obolibrary.org/obo/HP_0100164	Pseudoepiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the third toe.
http://purl.obolibrary.org/obo/HP_0100166	Stippling of the epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 3rd toe.
http://purl.obolibrary.org/obo/HP_0100178	Stippling of the epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 4th toe.
http://purl.obolibrary.org/obo/HP_0100187	Pseudoepiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the fourth toe.
http://purl.obolibrary.org/obo/HP_0100189	Stippling of the epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 4th toe.
http://purl.obolibrary.org/obo/HP_0100198	Pseudoepiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the fourth toe.
http://purl.obolibrary.org/obo/HP_0100200	Stippling of the epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 4th toe.
http://purl.obolibrary.org/obo/HP_0100211	Stippling of the epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100220	Pseudoepiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the fifth toe.
http://purl.obolibrary.org/obo/HP_0100222	Stippling of the epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100231	Pseudoepiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the fifth toe.
http://purl.obolibrary.org/obo/HP_0100233	Stippling of the epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100241	Ectopic respiratory mucosa	http://purl.obolibrary.org/obo/HP_0012253	Abnormal respiratory epithelium morphology		Ectopic respiratory epithelium presenting as a superficial lesion in the skin usually localized unilateral in the skin of the forearm and associated with ipsilateral hand malformations.
http://purl.obolibrary.org/obo/HP_0100244	Fibrosarcoma	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		A fibroblastic sarcoma is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells.
http://purl.obolibrary.org/obo/HP_0100245	Gastrointestinal desmoid tumor	http://purl.obolibrary.org/obo/HP_6001034	Desmoid tumor		Benign, slow-growing tumors without any metastatic potential. Despite their benign nature, they can damage nearby structures causing organ dysfunction. Histologically they resemble low-grade fibrosarcomas, but they are very locally aggressive and tend to recur even after complete resection. There is a tendency for recurrence in the setting of prior surgery and the most common localisation of these tumors is intraabdominal from smooth muscle cells of the instestine.
http://purl.obolibrary.org/obo/HP_0100246	Osteoma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		Osteomas are bony growths found most commonly on the skull and mandible; however, they may occur in any bone of the body. Osteomas do not usually cause clinical problems and do not become malignant.
http://purl.obolibrary.org/obo/HP_0100247	Recurrent singultus	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc.
http://purl.obolibrary.org/obo/HP_0100248	Hemiballismus	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		Hemiballismus is a rare movement disorder that is caused primarily by damage to various areas in the basal ganglia. Hemiballismus is usually characterized by involuntary flinging motions of the extremities. The movements are often violent and have wide amplitudes of motion. They are continuous and random and can involve proximal and/or distal muscles on one side of the body, while some cases even include the facial muscles. The more a patient is active, the more the movements increase. With relaxation comes a decrease in movements.
http://purl.obolibrary.org/obo/HP_0100249	Calcification of muscles	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Deposition of calcium salts in muscle tissue.
http://purl.obolibrary.org/obo/HP_0100250	Meningeal calcification	http://purl.obolibrary.org/obo/HP_0430048	Intracranial calcification		Calcium deposition affecting the Meninges.
http://purl.obolibrary.org/obo/HP_0100251	Multiple central nervous system lipomas	http://purl.obolibrary.org/obo/HP_0100835	Benign neoplasm of the central nervous system		The presence of multiple lipomas located in the central nervous system.
http://purl.obolibrary.org/obo/HP_0100253	Abnormality of the medullary cavity of the long bones	http://purl.obolibrary.org/obo/HP_0000940	Abnormal diaphysis morphology		An abnormality of the medullary cavity (medulla, innermost part), which is the central cavity of bone shafts where red bone marrow and/or yellow bone marrow (adipose tissue) is stored.
http://purl.obolibrary.org/obo/HP_0100256	Senile plaques	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		Senile plaques are extracellular deposits of amyloid in the gray matter of the brain.
http://purl.obolibrary.org/obo/HP_0100260	Mesoaxial polydactyly	http://purl.obolibrary.org/obo/HP_0010442	Polydactyly		The presence of a supernumerary finger or toe (not a thumb or hallux) involving the third or fourth metacarpal/tarsal with associated osseous syndactyly.
http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		An abnormality of the structure or form of the tendons, also often called sinews.
http://purl.obolibrary.org/obo/HP_0100266	Synostosis of carpals/tarsals	http://purl.obolibrary.org/obo/HP_0100240	Synostosis of joints		The carpus consists of the scaphoid, lunate, triquetal, pisiform, captitate, hamate, trapezoid, and trapezium bones. The tarsus consists of the talus, calcaneus, cuboid, cuneiform, and navicular bones. This term applies if there is any fusion among the bones of the carpus or tarsus.
http://purl.obolibrary.org/obo/HP_0100268	Upper lip pit	http://purl.obolibrary.org/obo/HP_0100269	Paramedian lip pit		Depression located on the vermilion of the upper lip, usually paramedian.
http://purl.obolibrary.org/obo/HP_0100270	Abnormality of dorsoventral patterning of the limbs	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		An abnormality resulting from a defect or disruption of dorsoventral patterning that normally happens during early development of the limbs. A disruption of the normal development of the dorsoventral axis may lead to a variable spectrum of different phenotypic abnormalities that may affect the nails and or palmar and dorsal side of the hands and/or feet, ultimately changing the normal dorsoventral appearance of the affected limbs.
http://purl.obolibrary.org/obo/HP_0100271	Hyponasal speech	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		Hyponasal speech is when there is an abnormally reduced nasal airflow during speech often in a setting of nasal obstruction or congestion.
http://purl.obolibrary.org/obo/HP_0100272	Branchial sinus	http://purl.obolibrary.org/obo/HP_0009794	Branchial anomaly		A congenital branchial sinus is a remnant of the embryonic branchial arches and their intervening clefts and pouches that has failed to regress completely. Sinuses typically have their external orifice inferior to the ramus of the mandible. They may traverse the parotid gland, and run in close vicinity to the facial nerve in the external auditory canal.
http://purl.obolibrary.org/obo/HP_0100274	Gustatory lacrimation	http://purl.obolibrary.org/obo/HP_0031910	Abnormal cranial nerve physiology		Gustatory lacrimation results from an aberrant innervation of fibers from the seventh cranial nerve to the pterygopalatine ganglion which are destined originally for the submandibular ganglion. This aberrant innervation leads to uncontrollable tearing while eating or in anticipation of a meal.
http://purl.obolibrary.org/obo/HP_0100275	Diffuse cerebellar atrophy	http://purl.obolibrary.org/obo/HP_0001272	Cerebellar atrophy		Diffuse unlocalised atrophy affecting the cerebellum.
http://purl.obolibrary.org/obo/HP_0100276	Skin pit	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A small, skin-lined tract that leads from the surface to deep within the tissues.
http://purl.obolibrary.org/obo/HP_0100277	Periauricular skin pits	http://purl.obolibrary.org/obo/HP_0100276	Skin pit		Benign congenital lesions of the periauricular soft tissue consisting of a blind-ending narrow tube or pit.
http://purl.obolibrary.org/obo/HP_0100279	Ulcerative colitis	http://purl.obolibrary.org/obo/HP_0100281	Chronic colitis		A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon.
http://purl.obolibrary.org/obo/HP_0100280	Crohn's disease	http://purl.obolibrary.org/obo/HP_0004386	Gastrointestinal inflammation		A chronic granulomatous inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea which may be bloody, vomiting, or weight loss, but may also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration. Crohn's disease is thought to be an autoimmune disease, in which the body's immune system attacks the gastrointestinal tract, causing inflammation.
http://purl.obolibrary.org/obo/HP_0100281	Chronic colitis	http://purl.obolibrary.org/obo/HP_0002583	Colitis		A chronic inflammatory disease of the large intestine (colon, cecum and rectum).
http://purl.obolibrary.org/obo/HP_0100282	Acute colitis	http://purl.obolibrary.org/obo/HP_0002583	Colitis		An acute and self-limited inflammatory disease of the large intestine (colon, cecum and rectum).
http://purl.obolibrary.org/obo/HP_0100283	EMG: continuous motor unit activity at rest	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		Continuous electromyographic activity of motor units at rest, i.e., without voluntary movement of the muscles.
http://purl.obolibrary.org/obo/HP_0100284	EMG: myotonic discharges	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		High frequency discharges in electromyography (EMG) that vary in amplitude and frequency, waxing and waning continuously with firing frequencies ranging from 150/second down to 20/second and producing a sound that has been referred to as a dive bomber sound.
http://purl.obolibrary.org/obo/HP_0100285	EMG: impaired neuromuscular transmission	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		An electromyographic finding associated with erratic or absent neuromuscular transmission with erratic, moment-to-moment changes in the shape of the motor unit potential (MUP).
http://purl.obolibrary.org/obo/HP_0100287	EMG: slow motor conduction	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		The presence of reduced conduction velocity of motor nerves on electromyography.
http://purl.obolibrary.org/obo/HP_0100288	EMG: myokymic discharges	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		The presence of spontaneous bursts of rapidly firing potentials that recur at regular intervals of 2-10 per second and are unaffected by voluntary effort. This is an electromyographic (EMG) finding.
http://purl.obolibrary.org/obo/HP_0100291	Delayed somatosensory central conduction time	http://purl.obolibrary.org/obo/HP_0007377	Abnormality of somatosensory evoked potentials		An abnormal increase (delay) in the somatosensory central conduction time (CCT), which can be measured from the peak of N13 to the peak of N20 (peak CCT) or from the onset of N11 to the onset of N20 (onset CCT).
http://purl.obolibrary.org/obo/HP_0100292	Amyloidosis of peripheral nerves	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		The presence of amyloid deposition in the nerves of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0100293	Hypertrophied muscle fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		The presence of an increased amount of muscle fibers with an increased diameter. This feature can be ascertained by microscopic examination of a muscle biopsy sample. Together with fiber size variation and atrophied muscle fibers, and hypertrophied muscle fibers are commonly found in myopathies.
http://purl.obolibrary.org/obo/HP_0100297	Increased endomysial connective tissue	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		An increased volume of the endomysium, which is a connective tissue sheath that surrounds each muscle fiber. Together, bundles of muscle fibers form a fasciculus, surrounded by another layer of connective tissue called the perimysium.
http://purl.obolibrary.org/obo/HP_0100301	Muscle fiber tubular inclusions	http://purl.obolibrary.org/obo/HP_0100303	Muscle fiber cytoplasmatic inclusion bodies		Unusual regions of densely packed membranous tubules known as tubular aggregates which present as membranous inclusions, derived from membranes of sarcoplasmic reticulum and mitochondria, containing miscellaneous proteins with a variety of enzymatic activities.
http://purl.obolibrary.org/obo/HP_0100304	Muscle fiber intranuclear inclusion bodies	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		The presence of inclusion bodies within the nucleus of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins.
http://purl.obolibrary.org/obo/HP_0100305	Ring fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Ring fibers are formed by a bundle of peripheral myofibrils which are circumferentially oriented such that they encircle the internal portion of the sarcoplasm which is normal in structure and orientation.
http://purl.obolibrary.org/obo/HP_0100306	Muscle fiber hyaline bodies	http://purl.obolibrary.org/obo/HP_0100303	Muscle fiber cytoplasmatic inclusion bodies		Subsarcolemmal, eosinophilic glass-like regions in the cytoplasm of muscle fibers. Hyaline bodies show significant reactivity to myofibrillar ATPase after acid pre-incubation and with immunohistochemistry, show intense reactivity with only slow myosin heavy chain. Electron microscopy of the affected areas show a lack of myofibrils and a uniform, finely granular matrix, sometimes suggesting a filamentous nature, containing few scattered nuclei and mitochondria.
http://purl.obolibrary.org/obo/HP_0100308	Cerebral cortical hemiatrophy	http://purl.obolibrary.org/obo/HP_0002120	Cerebral cortical atrophy		Atrophy of one side of the brain, characterized by findings including thinning of the cerebral cortex, reduced volume of the cerebral white matter with abnormal myelination, and enlargement of the ispilateral fourth ventricle.
http://purl.obolibrary.org/obo/HP_0100309	Subdural hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial hemorrhage		Hemorrhage occurring between the dura mater and the arachnoid mater.
http://purl.obolibrary.org/obo/HP_0100310	Epidural hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial hemorrhage		Hemorrhage occurring between the dura mater and the skull.
http://purl.obolibrary.org/obo/HP_0100311	Cerebral ventricular adhesions	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		Bands of scar-like tissue that have formed within a cerebral ventricle.
http://purl.obolibrary.org/obo/HP_0100312	Cerebral germinoma	http://purl.obolibrary.org/obo/HP_0100620	Germinoma		The presence of a germ cell tumor of the cerebrum.
http://purl.obolibrary.org/obo/HP_0100313	Cerebral granulomatosis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		Cerebral inflammation involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells.
http://purl.obolibrary.org/obo/HP_0100316	Hirano bodies	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		Intracellular aggregates of actin and actin-associated proteins within nerve cells.
http://purl.obolibrary.org/obo/HP_0100317	Argyrophilic inclusion bodies	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		Presence of abundant argyrophilic grains and coiled bodies on microscopic examination of brain tissue.
http://purl.obolibrary.org/obo/HP_0100318	Lafora bodies	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		An intraneuronal inclusion body composed of acid mucopolysaccharides.
http://purl.obolibrary.org/obo/HP_0100319	Cerebral hyaline bodies	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		Cerebral eosinophilic, discrete, intracytoplasmatic inclusions of unknown significance.
http://purl.obolibrary.org/obo/HP_0100320	Rosenthal fibers	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		Thick, elongated, worm-like or corkscrew eosinophilic bundle that are found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders.
http://purl.obolibrary.org/obo/HP_0100323	Juvenile aseptic necrosis	http://purl.obolibrary.org/obo/HP_0010885	Avascular necrosis		Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers.
http://purl.obolibrary.org/obo/HP_0100327	Cow milk allergy	http://purl.obolibrary.org/obo/HP_0410327	Dairy allergy		Hypersensitivity in form of an adverse immune reaction against cow milk protein.
http://purl.obolibrary.org/obo/HP_0100328	Carpometacarpal synostosis	http://purl.obolibrary.org/obo/HP_0009701	Metacarpal synostosis		Fusion involving carpal and metacarpal bones.
http://purl.obolibrary.org/obo/HP_0100333	Unilateral cleft lip	http://purl.obolibrary.org/obo/HP_0100335	Non-midline cleft of the upper lip		A non-midline cleft of the upper lip on one side only.
http://purl.obolibrary.org/obo/HP_0100335	Non-midline cleft of the upper lip	http://purl.obolibrary.org/obo/HP_0000204	Cleft upper lip		Clefting (gap or groove) of the upper lip affecting the lateral portions of the upper lip rather than the midline/median region.
http://purl.obolibrary.org/obo/HP_0100348	Contracture of the proximal interphalangeal joint of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010327	Flexion contracture of the 2nd toe		The proximal interphalangeal joint of the 2nd toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100349	Contracture of the proximal interphalangeal joint of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010333	Flexion contracture of 3rd toe		The proximal interphalangeal joint of the 3rd toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100350	Contracture of the proximal interphalangeal joint of the 4th toe	http://purl.obolibrary.org/obo/HP_0010339	Flexion contracture of the 4th toe		The proximal interphalangeal joint of the 4th toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100351	Contractures of the proximal interphalangeal joint of the 5th toe	http://purl.obolibrary.org/obo/HP_0010345	Flexion contracture of the 5th toe		The proximal interphalangeal joint of the fifth toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100352	Contracture of the distal interphalangeal joint of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010327	Flexion contracture of the 2nd toe		The distal interphalangeal joint of the 2nd toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100353	Contracture of the distal interphalangeal joint of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010333	Flexion contracture of 3rd toe		The distal interphalangeal joint of the 3rd toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100354	Contracture of the distal interphalangeal joint of the 4th toe	http://purl.obolibrary.org/obo/HP_0010339	Flexion contracture of the 4th toe		The distal interphalangeal joint of the 4th toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100355	Contractures of the distal interphalangeal joint of the 5th toe	http://purl.obolibrary.org/obo/HP_0010345	Flexion contracture of the 5th toe		The distal interphalangeal joint of the 5th toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100356	Contracture of the metatarsophalangeal joint of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010327	Flexion contracture of the 2nd toe		The joint between the second metatarsal and the proximal phalanx of the 2nd toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100357	Contracture of the metatarsophalangeal joint of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010333	Flexion contracture of 3rd toe		The joint between the third metatarsal and the proximal phalanx of the third toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100358	Contracture of the metatarsophalangeal joint of the 4th toe	http://purl.obolibrary.org/obo/HP_0010339	Flexion contracture of the 4th toe		The joint between the fourth metatarsal and the proximal phalanx of the fourth toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100359	Contracture of the metatarsophalangeal joint of the 5th toe	http://purl.obolibrary.org/obo/HP_0010345	Flexion contracture of the 5th toe		The joint between the fifth metatarsal and the proximal phalanx of the fifth toe cannot be straightened actively or passively.
http://purl.obolibrary.org/obo/HP_0100366	Short phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010746	Hypoplasia of the phalanges of the toes		Developmental hypoplasia of the phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100367	Short phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010746	Hypoplasia of the phalanges of the toes		Developmental hypoplasia of one or more phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100368	Short phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010746	Hypoplasia of the phalanges of the toes		Developmental hypoplasia of one or more phalanx of little toe.
http://purl.obolibrary.org/obo/HP_0100375	Aplasia/hypoplasia of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010370	Abnormal morphology of the proximal phalanx of the 3rd toe		Absence (agenesis) or underdevelopment of the proximal phalanx of the 3rd toe.
http://purl.obolibrary.org/obo/HP_0100376	Aplasia/hypoplasia of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010382	Abnormal morphology of the proximal phalanx of the 4th toe		Absence (agenesis) or underdevelopment of the proximal phalanx of the 4th toe.
http://purl.obolibrary.org/obo/HP_0100377	Aplasia/hypoplasia of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010394	Abnormal morphology of the proximal phalanx of the 5th toe		Absence (agenesis) or underdevelopment of the proximal phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100378	Absent distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100369	Aplasia/Hypoplasia of the distal phalanx of the 3rd toe		Developmental aplasia of the distal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100381	Absent middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100387	Aplasia of the middle phalanges of the toes		Developmental aplasia of the middle phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100384	Absent proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100388	Aplasia of the proximal phalanges of the toes		Absence of proximal phalanx of third toe, owing to a congenital defect of development.
http://purl.obolibrary.org/obo/HP_0100389	Short distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100369	Aplasia/Hypoplasia of the distal phalanx of the 3rd toe		Developmental hypoplasia of the distal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100390	Short distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100370	Aplasia/Hypoplasia of the distal phalanx of the 4th toe		Developmental hypoplasia of the distal phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100391	Short distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100371	Aplasia/Hypoplasia of the distal phalanx of the 5th toe		Developmental hypoplasia of the distal phalanx of little toe.
http://purl.obolibrary.org/obo/HP_0100392	Short middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100372	Aplasia/Hypoplasia of the middle phalanx of the 3rd toe		Developmental hypoplasia of the middle phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100393	Short middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100373	Aplasia/Hypoplasia of the middle phalanx of the 4th toe		Developmental hypoplasia of the middle phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100394	Short middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100374	Aplasia/Hypoplasia of the middle phalanx of the 5th toe		Developmental hypoplasia of the middle phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100395	Short proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100375	Aplasia/hypoplasia of the proximal phalanx of the 3rd toe		Abnormal reduction in length of proximal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100396	Short proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100376	Aplasia/hypoplasia of the proximal phalanx of the 4th toe		Developmental hypoplasia of the proximal phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100397	Short proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100377	Aplasia/hypoplasia of the proximal phalanx of the 5th toe		Developmental hypoplasia of the proximal phalanx of fifth toe.
http://purl.obolibrary.org/obo/HP_0100398	Duplication of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010368	Abnormality of the distal phalanx of the 3rd toe		Partial or complete duplication of distal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100399	Duplication of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010380	Abnormality of the distal phalanx of the 4th toe		Partial or complete duplication of the distal phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100400	Duplication of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010392	Abnormality of the distal phalanx of the 5th toe		Partial or complete duplication of the distal phalanx of little toe.
http://purl.obolibrary.org/obo/HP_0100401	Duplication of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010369	Abnormality of the middle phalanx of the 3rd toe		Partial or complete duplication of middle phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100402	Duplication of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010381	Abnormality of the middle phalanx of the 4th toe		Partial or complete duplication of middle phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100403	Duplication of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010393	Abnormality of the middle phalanx of the 5th toe		Partial or complete duplication of the middle phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100404	Duplication of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010370	Abnormal morphology of the proximal phalanx of the 3rd toe		Partial or complete duplication of proximal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100405	Duplication of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010382	Abnormal morphology of the proximal phalanx of the 4th toe		Partial or complete duplication of the proximal phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100406	Duplication of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010394	Abnormal morphology of the proximal phalanx of the 5th toe		Partial or complete duplication of the proximal phalanx of fifth toe.
http://purl.obolibrary.org/obo/HP_0100407	Complete duplication of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100398	Duplication of the distal phalanx of the 3rd toe		Complete duplication of distal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100408	Complete duplication of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100399	Duplication of the distal phalanx of the 4th toe		Complete duplication of the distal phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100409	Complete duplication of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100400	Duplication of the distal phalanx of the 5th toe		Complete duplication of the distal phalanx of little toe.
http://purl.obolibrary.org/obo/HP_0100410	Complete duplication of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100401	Duplication of the middle phalanx of the 3rd toe		Complete duplication of middle phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100411	Complete duplication of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100402	Duplication of the middle phalanx of the 4th toe		Complete duplication of middle phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100412	Complete duplication of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100403	Duplication of the middle phalanx of the 5th toe		Complete duplication of the middle phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100413	Complete duplication of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100404	Duplication of the proximal phalanx of the 3rd toe		Complete duplication of proximal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100415	Complete duplication of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100406	Duplication of the proximal phalanx of the 5th toe		Complete duplication of the proximal phalanx of fifth toe.
http://purl.obolibrary.org/obo/HP_0100416	Partial duplication of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100398	Duplication of the distal phalanx of the 3rd toe		Partial duplication of distal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100417	Partial duplication of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100399	Duplication of the distal phalanx of the 4th toe		Partial duplication of the distal phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100418	Partial duplication of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100400	Duplication of the distal phalanx of the 5th toe		Partial duplication of the distal phalanx of little toe.
http://purl.obolibrary.org/obo/HP_0100419	Partial duplication of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100401	Duplication of the middle phalanx of the 3rd toe		Partial duplication of middle phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100420	Partial duplication of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100402	Duplication of the middle phalanx of the 4th toe		Partial duplication of middle phalanx of fourth toe.
http://purl.obolibrary.org/obo/HP_0100421	Partial duplication of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100403	Duplication of the middle phalanx of the 5th toe		Partial duplication of the middle phalanx of the 5th toe.
http://purl.obolibrary.org/obo/HP_0100422	Partial duplication of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100404	Duplication of the proximal phalanx of the 3rd toe		Partial duplication of proximal phalanx of third toe.
http://purl.obolibrary.org/obo/HP_0100424	Partial duplication of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100406	Duplication of the proximal phalanx of the 5th toe		Partial duplication of the proximal phalanx of fifth toe.
http://purl.obolibrary.org/obo/HP_0100434	Bullet-shaped middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010361	Bullet-shaped 3rd toe phalanx		An abnormal morphology of the middle phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100435	Bullet-shaped middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010373	Bullet-shaped 4th toe phalanx		An abnormal morphology of the middle phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100436	Bullet-shaped middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010385	Bullet-shaped 5th toe phalanx		An abnormal morphology of the middle phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100437	Bullet-shaped proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010361	Bullet-shaped 3rd toe phalanx		An abnormal morphology of the proximal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100438	Bullet-shaped proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010373	Bullet-shaped 4th toe phalanx		An abnormal morphology of the proximal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100439	Bullet-shaped proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010385	Bullet-shaped 5th toe phalanx		An abnormal morphology of the proximal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100440	Bullet-shaped distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010361	Bullet-shaped 3rd toe phalanx		An abnormal morphology of the distal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100441	Bullet-shaped distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010373	Bullet-shaped 4th toe phalanx		An abnormal morphology of the distal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100442	Bullet-shaped distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010385	Bullet-shaped 5th toe phalanx		An abnormal morphology of the distal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.
http://purl.obolibrary.org/obo/HP_0100443	Curved middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010369	Abnormality of the middle phalanx of the 3rd toe		A deviation from the normal straight form of the middle phalanx of the third toe.
http://purl.obolibrary.org/obo/HP_0100444	Curved middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010381	Abnormality of the middle phalanx of the 4th toe		A deviation from the normal straight form of the middle phalanx of the fourth toe.
http://purl.obolibrary.org/obo/HP_0100445	Curved middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010393	Abnormality of the middle phalanx of the 5th toe		A deviation from the normal straight form of the middle phalanx of the fifth toe.
http://purl.obolibrary.org/obo/HP_0100446	Curved proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010370	Abnormal morphology of the proximal phalanx of the 3rd toe		A deviation from the normal straight form of the proximal phalanx of the third toe.
http://purl.obolibrary.org/obo/HP_0100447	Curved proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010382	Abnormal morphology of the proximal phalanx of the 4th toe		A deviation from the normal straight form of the proximal phalanx of the fourth toe.
http://purl.obolibrary.org/obo/HP_0100448	Curved proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010394	Abnormal morphology of the proximal phalanx of the 5th toe		A deviation from the normal straight form of the proximal phalanx of the fifth toe.
http://purl.obolibrary.org/obo/HP_0100449	Curved distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010368	Abnormality of the distal phalanx of the 3rd toe		A deviation from the normal straight form of the distal phalanx of the third toe.
http://purl.obolibrary.org/obo/HP_0100450	Curved distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010380	Abnormality of the distal phalanx of the 4th toe		A deviation from the normal straight form of the distal phalanx of the fourth toe.
http://purl.obolibrary.org/obo/HP_0100451	Curved distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010392	Abnormality of the distal phalanx of the 5th toe		A deviation from the normal straight form of the distal phalanx of the fifth toe.
http://purl.obolibrary.org/obo/HP_0100462	Patchy sclerosis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100937	Sclerosis of the middle phalanx of the 4th toe		Uneven increase in bone density of the middle phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0100463	Patchy sclerosis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100938	Sclerosis of the middle phalanx of the 5th toe		Uneven increase in bone density of the middle phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0100465	Patchy sclerosis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100933	Sclerosis of the proximal phalanx of the 4th toe		Uneven increase in bone density of the proximal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0100466	Patchy sclerosis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100934	Sclerosis of the proximal phalanx of the 5th toe		Uneven increase in bone density of the proximal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0100468	Patchy sclerosis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100941	Sclerosis of the distal phalanx of the 4th toe		Uneven increase in bone density of the distal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0100469	Patchy sclerosis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100942	Sclerosis of the distal phalanx of the 5th toe		Patchy (irregular) increase in bone density of the distal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.
http://purl.obolibrary.org/obo/HP_0100476	DIstal 3rd toe symphalangism	http://purl.obolibrary.org/obo/HP_0010365	Third toe symphalangism		Bony fusion at the distal interphalangeal joint of the third toe (end-to-end fusion of the medial and distal phalanx of the third toe).
http://purl.obolibrary.org/obo/HP_0100477	Distal 4th toe symphalangism	http://purl.obolibrary.org/obo/HP_0010377	Fourth toe symphalangism		Bony fusion at the distal interphalangeal joint of the fourth toe (end-to-end fusion of the medial and distal phalanx of the fourth toe).
http://purl.obolibrary.org/obo/HP_0100478	Distal 5th toe symphalangism	http://purl.obolibrary.org/obo/HP_0010389	Fifth toe symphalangism		Bony fusion at the distal interphalangeal joint of the fifth, i.e., little, toe (end-to-end fusion of the medial and distal phalanx of the fifth toe).
http://purl.obolibrary.org/obo/HP_0100480	Proximal 3rd toe symphalangism	http://purl.obolibrary.org/obo/HP_0010365	Third toe symphalangism		Bony fusion of the middle and proximal phalanges of the 3rd toe.
http://purl.obolibrary.org/obo/HP_0100481	Proximal 4th toe symphalangism	http://purl.obolibrary.org/obo/HP_0010377	Fourth toe symphalangism		Bony fusion at the proximal interphalangeal joint of the fourth (little) toe (end-to-end fusion of the proximal and medial phalanx of the fourth toe).
http://purl.obolibrary.org/obo/HP_0100482	Proximal 5th toe symphalangism	http://purl.obolibrary.org/obo/HP_0010389	Fifth toe symphalangism		Bony fusion at the proximal interphalangeal joint of the fifth (little) toe (end-to-end fusion of the proximal and medial phalanx of the fifth toe).
http://purl.obolibrary.org/obo/HP_0100483	Second ray metatarsophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0001440	Metatarsal synostosis		Congenital fusion of the second metatarsal bone with the proximal phalanx of the second toe.
http://purl.obolibrary.org/obo/HP_0100484	Third ray metatarsophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0010390	Triangular shaped phalanges of the 5th toe		Congenital fusion of the third metatarsal bone with the proximal phalanx of the third toe.
http://purl.obolibrary.org/obo/HP_0100485	Fourth ray metatarsophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0001440	Metatarsal synostosis		Congenital fusion of the fourth metatarsal bone with the proximal phalanx of the fourth toe.
http://purl.obolibrary.org/obo/HP_0100486	Fifth ray metatarsophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0001440	Metatarsal synostosis		Congenital fusion of the fifth metatarsal bone with the proximal phalanx of the fifth toe.
http://purl.obolibrary.org/obo/HP_0100488	First ray metatarsophalangeal synostosis	http://purl.obolibrary.org/obo/HP_0010073	Synostosis involving the 1st metatarsal		Congenital fusion of the firth metatarsal bone with the proximal phalanx of the hallux.
http://purl.obolibrary.org/obo/HP_0100493	Hypoammonemia	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		A decreased concentration of ammonia in the blood.
http://purl.obolibrary.org/obo/HP_0100494	Abnormal mast cell morphology	http://purl.obolibrary.org/obo/HP_0001911	Abnormal granulocyte morphology		Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation.
http://purl.obolibrary.org/obo/HP_0100495	Mastocytosis	http://purl.obolibrary.org/obo/HP_0100494	Abnormal mast cell morphology		The presence of an increased number of mast cells and CD34+ mast cell precursors in the body.
http://purl.obolibrary.org/obo/HP_0100497	Decreased circulating vitamin B3 concentration	http://purl.obolibrary.org/obo/HP_0100496	Abnormal circulating vitamin B3 concentration		The concentration of vitamin B3 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100501	Recurrent bronchiolitis	http://purl.obolibrary.org/obo/HP_0011950	Unusual bronchiolitis		An increased susceptibility to bronchiolitis as manifested by a history of recurrent bronchiolitis.
http://purl.obolibrary.org/obo/HP_0100503	Decreased circulating vitamin B1 concentration	http://purl.obolibrary.org/obo/HP_0100504	Decreased circulating vitamin B2 concentration		The concentration of vitamin B1 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100504	Decreased circulating vitamin B2 concentration	http://purl.obolibrary.org/obo/HP_0004340	Abnormal circulating vitamin B concentration		The concentration of vitamin B2 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100505	Decreased circulating vitamin B5 concentration	http://purl.obolibrary.org/obo/HP_0004340	Abnormal circulating vitamin B concentration		The concentration of vitamin B5 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100506	Decreased circulating vitamin B8 concentration	http://purl.obolibrary.org/obo/HP_0004340	Abnormal circulating vitamin B concentration		The concentration of vitamin B8 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100507	Decreased circulating folate concentration	http://purl.obolibrary.org/obo/HP_0040087	Abnormal circulating folate concentration		The concentration of folic acid in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100508	Abnormality of vitamin metabolism	http://purl.obolibrary.org/obo/HP_0032245	Abnormal metabolism		An anomaly in the metabolism of a vitamin.
http://purl.obolibrary.org/obo/HP_0100509	Abnormal circulating vitamin C concentration	http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration		Concentration of vitamin C in the blood circulation outside of normal limits.
http://purl.obolibrary.org/obo/HP_0100510	Decreased circulating vitamin C concentration	http://purl.obolibrary.org/obo/HP_0100509	Abnormal circulating vitamin C concentration		The concentration of vitamin C in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0100511	Abnormal circulating vitamin D concentration	http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration		Concentration of vitamin D or a vitamin D metabolite in the blood circulation outside of normal limits.
http://purl.obolibrary.org/obo/HP_0100513	Decreased circulating vitamin E concentration	http://purl.obolibrary.org/obo/HP_0100514	Abnormal circulating vitamin E concentration		A reduced concentration of vitamin E in the blood circulation. Vitamin E is a lipophilic vitamin that is also known as alpha-tocopherol.
http://purl.obolibrary.org/obo/HP_0100514	Abnormal circulating vitamin E concentration	http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration		Concentration of vitamin E in the blood circulation outside of normal limits.
http://purl.obolibrary.org/obo/HP_0100515	Pollakisuria	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Increased frequency of urination.
http://purl.obolibrary.org/obo/HP_0100516	Neoplasm of the ureter	http://purl.obolibrary.org/obo/HP_0010786	Urinary tract neoplasm		The presence of a neoplasm of the ureter.
http://purl.obolibrary.org/obo/HP_0100517	Neoplasm of the urethra	http://purl.obolibrary.org/obo/HP_0010786	Urinary tract neoplasm		The presence of a neoplasm of the urethra.
http://purl.obolibrary.org/obo/HP_0100518	Dysuria	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		Painful or difficult urination.
http://purl.obolibrary.org/obo/HP_0100519	Anuria	http://purl.obolibrary.org/obo/HP_0011037	Decreased urine output		Absence of urine, clinically classified as below 50ml/day.
http://purl.obolibrary.org/obo/HP_0100520	Oliguria	http://purl.obolibrary.org/obo/HP_0011037	Decreased urine output		Low output of urine, clinically classified as an output below 300-500ml/day.
http://purl.obolibrary.org/obo/HP_0100521	Neoplasm of the thymus	http://purl.obolibrary.org/obo/HP_0000777	Abnormal thymus morphology		A tumor (abnormal growth of tissue) of the thymus.
http://purl.obolibrary.org/obo/HP_0100522	Thymoma	http://purl.obolibrary.org/obo/HP_0100521	Neoplasm of the thymus		A tumor originating from the epithelial cells of the thymus.
http://purl.obolibrary.org/obo/HP_0100524	Limb duplication	http://purl.obolibrary.org/obo/HP_0002813	Abnormal limb bone morphology		Congenital duplication of all or part of a limb.
http://purl.obolibrary.org/obo/HP_0100525	Urachus fistula	http://purl.obolibrary.org/obo/HP_0010478	Abnormality of the urachus		Persistence of the urachal canal with drainage of urine from the bladder through the persistent allantois canal to the umbilicus.
http://purl.obolibrary.org/obo/HP_0100528	Pleuropulmonary blastoma	http://purl.obolibrary.org/obo/HP_0100552	Neoplasm of the tracheobronchial system		A rare cancer originating in the lung or pleural cavity that occurs most often in infants and young children but also has been reported in adults. Pleuropulmonary blastoma is regarded as malignant.
http://purl.obolibrary.org/obo/HP_0100531	Wind-swept deformity of the knees	http://purl.obolibrary.org/obo/HP_0002970	Genu varum		The appearance of abnormal valgus deformity in one knee in association with varus deformity in the other.
http://purl.obolibrary.org/obo/HP_0100532	Scleritis	http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye		Inflammation of the sclera.
http://purl.obolibrary.org/obo/HP_0100534	Episcleritis	http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye		Inflammation of the episclera, a thin layer of tissue covering the white part (sclera) of the eye.
http://purl.obolibrary.org/obo/HP_0100536	Abnormal fascia morphology	http://purl.obolibrary.org/obo/HP_0003549	Abnormality of connective tissue		An abnormality of fascia.
http://purl.obolibrary.org/obo/HP_0100537	Fasciitis	http://purl.obolibrary.org/obo/HP_0100536	Abnormal fascia morphology		Inflammation of fascia, the tissue under the skin and over the muscle.
http://purl.obolibrary.org/obo/HP_0100539	Periorbital edema	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Edema affecting the region situated around the orbit of the eye.
http://purl.obolibrary.org/obo/HP_0100540	Palpebral edema	http://purl.obolibrary.org/obo/HP_0100539	Periorbital edema		Edema in the region of the eyelids.
http://purl.obolibrary.org/obo/HP_0100541	Femoral hernia	http://purl.obolibrary.org/obo/HP_0004299	Hernia of the abdominal wall		A hernia which occurs just below the inguinal ligament, where abdominal contents pass through a naturally occurring weakness called the femoral canal.
http://purl.obolibrary.org/obo/HP_0100544	Neoplasm of the heart	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the heart.
http://purl.obolibrary.org/obo/HP_0100546	Carotid artery stenosis	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		Narrowing of the carotid arteries.
http://purl.obolibrary.org/obo/HP_0100550	Tendon rupture	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		Breakage (tear) of a tendon.
http://purl.obolibrary.org/obo/HP_0100551	Neoplasm of the trachea	http://purl.obolibrary.org/obo/HP_0100552	Neoplasm of the tracheobronchial system		A neoplasm of the trachea.
http://purl.obolibrary.org/obo/HP_0100553	Hemihypertrophy of lower limb	http://purl.obolibrary.org/obo/HP_0100559	Lower limb asymmetry		Overgrowth of only one leg.
http://purl.obolibrary.org/obo/HP_0100554	Hemihypertrophy of upper limb	http://purl.obolibrary.org/obo/HP_0100560	Upper limb asymmetry		Overgrowth of only one arm.
http://purl.obolibrary.org/obo/HP_0100556	Hemiatrophy	http://purl.obolibrary.org/obo/HP_0100555	Asymmetric growth		Undergrowth of the limbs that affects only one side.
http://purl.obolibrary.org/obo/HP_0100557	Hemiatrophy of lower limb	http://purl.obolibrary.org/obo/HP_0100559	Lower limb asymmetry		Unilateral atrophy (reduction in size) of a leg.
http://purl.obolibrary.org/obo/HP_0100558	Hemiatrophy of upper limb	http://purl.obolibrary.org/obo/HP_0100560	Upper limb asymmetry		Unilateral atrophy (reduction in size) of an arm.
http://purl.obolibrary.org/obo/HP_0100559	Lower limb asymmetry	http://purl.obolibrary.org/obo/HP_0100555	Asymmetric growth		A difference in length or diameter between the left and right leg.
http://purl.obolibrary.org/obo/HP_0100560	Upper limb asymmetry	http://purl.obolibrary.org/obo/HP_0100555	Asymmetric growth		Difference in length or size between the right and left arm.
http://purl.obolibrary.org/obo/HP_0100562	Diplomyelia	http://purl.obolibrary.org/obo/HP_0100561	Spinal cord lesion		Duplication of the spinal cord.
http://purl.obolibrary.org/obo/HP_0100563	Diastomatomyelia	http://purl.obolibrary.org/obo/HP_0100561	Spinal cord lesion		Coexistence of two hemicords, at variable levels, causing splaying of the posterior vertebral elements. Results in neurological deficits in lower limb or perineum.
http://purl.obolibrary.org/obo/HP_0100564	Triplomyelia	http://purl.obolibrary.org/obo/HP_0100561	Spinal cord lesion		Triplication of the spinal cord - extremely rare.
http://purl.obolibrary.org/obo/HP_0100565	Hydromyelia	http://purl.obolibrary.org/obo/HP_0100561	Spinal cord lesion		Dilation of central canal from incomplete fusion of the posterior columns or persistence of the primitive large canal of the embryo.
http://purl.obolibrary.org/obo/HP_0100566	Amyelia	http://purl.obolibrary.org/obo/HP_0100561	Spinal cord lesion		Congenital absence of the spinal cord.
http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the endocrine system.
http://purl.obolibrary.org/obo/HP_0100569	Abnormally ossified vertebrae	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		An abnormality of the formation and mineralization of one or more vertebrae.
http://purl.obolibrary.org/obo/HP_0100570	Carcinoid tumor	http://purl.obolibrary.org/obo/HP_0100634	Neuroendocrine neoplasm		A tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin.
http://purl.obolibrary.org/obo/HP_0100571	Cardiac diverticulum	http://purl.obolibrary.org/obo/HP_0001713	Abnormal cardiac ventricle morphology		A cardiac diverticulum is a rare congenital malformation which is either fibrous or muscular.
http://purl.obolibrary.org/obo/HP_0100572	Fibrous cardiac diverticulum	http://purl.obolibrary.org/obo/HP_0100571	Cardiac diverticulum		A fibrous cardiac diverticulum refers to an aneurysm and usually appears as an isolated congenital anomaly.
http://purl.obolibrary.org/obo/HP_0100574	Biliary tract neoplasm	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		A tumor (abnormal growth of tissue) of the biliary system.
http://purl.obolibrary.org/obo/HP_0100575	Neoplasm of the gallbladder	http://purl.obolibrary.org/obo/HP_0100574	Biliary tract neoplasm		The presence of a neoplasm of the gallbladder.
http://purl.obolibrary.org/obo/HP_0100576	Amaurosis fugax	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		A transient visual disturbance that is typically caused by a circulatory, ocular or neurological underlying condition.
http://purl.obolibrary.org/obo/HP_0100578	Lipoatrophy	http://purl.obolibrary.org/obo/HP_0009125	Lipodystrophy		Localized loss of fat tissue.
http://purl.obolibrary.org/obo/HP_0100580	Barrett esophagus	http://purl.obolibrary.org/obo/HP_0100751	Esophageal neoplasm		An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system.
http://purl.obolibrary.org/obo/HP_0100581	Dilatation of renal calices	http://purl.obolibrary.org/obo/HP_0011130	Abnormal renal calyx morphology		An abnormal enlargement of the renal calices, the system of ducts of the kidney that collect urine.
http://purl.obolibrary.org/obo/HP_0100582	Nasal polyposis	http://purl.obolibrary.org/obo/HP_0000433	Abnormal nasal mucosa morphology		Polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are freely movable and nontender overgrowths of the mucosa that frequently accompany allergic rhinitis.
http://purl.obolibrary.org/obo/HP_0100583	Corneal perforation	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		A rupture of the cornea through which a portion of the iris protrudes.
http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin	http://purl.obolibrary.org/obo/HP_0001009	Telangiectasia		Presence of small, permanently dilated blood vessels near the surface of the skin, visible as small focal red lesions.
http://purl.obolibrary.org/obo/HP_0100586	Sterile pyuria	http://purl.obolibrary.org/obo/HP_0012085	Pyuria		Patients who routinely have greater than 20 leukocytes per microliter, but have abacterial urine, are said to have sterile pyuria.
http://purl.obolibrary.org/obo/HP_0100588	Paraphimosis	http://purl.obolibrary.org/obo/HP_0100587	Abnormal preputium morphology		The foreskin becomes trapped behind the glans penis, and cannot be pulled back to its normal flaccid position covering the glans penis.
http://purl.obolibrary.org/obo/HP_0100589	Urogenital fistula	http://purl.obolibrary.org/obo/HP_0000119	Abnormality of the genitourinary system		The presence of a fistula affecting the genitourinary system.
http://purl.obolibrary.org/obo/HP_0100592	Peritoneal abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		The presence of an abscess of the peritoneum.
http://purl.obolibrary.org/obo/HP_0100594	Esophageal web	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Thin (2-3mm) membranes of normal esophageal tissue consisting of mucosa and submucosa that can be congenital or acquired. Congenital webs commonly appear in the middle and inferior third of the esophagus, and they are more likely to be circumferential with a central or eccentric orifice. Acquired webs are much more common than congenital webs and typically appear in the cervical area (postcricoid). Clinical symptoms of this condition are selective (solid more than liquids) dysphagia, thoracic pain, nasopharyngeal reflux, aspiration, perforation and food impaction (the last two are very rare).
http://purl.obolibrary.org/obo/HP_0100595	Camptocormia	http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column		An abnormal forward-flexed posture e.g. forward flexion of the spine, which is noticeable when standing or walking but disappears when lying down. It is becoming an increasingly recognized feature of Parkinson's disease and dystonic disorders.
http://purl.obolibrary.org/obo/HP_0100596	Absent nares	http://purl.obolibrary.org/obo/HP_0005288	Abnormal nostril morphology		The nostrils (the paired channels of the nose) are not present.
http://purl.obolibrary.org/obo/HP_0100599	Bifid penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Two penile structures, separated from the tip to the base of the shaft.
http://purl.obolibrary.org/obo/HP_0100600	Penoscrotal transposition	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		A partial or complete positional exchange between the penis and the scrotum, with positioning of the scrotum superior to the penis.
http://purl.obolibrary.org/obo/HP_0100601	Eclampsia	http://purl.obolibrary.org/obo/HP_0100603	Toxemia of pregnancy		An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders.
http://purl.obolibrary.org/obo/HP_0100602	Preeclampsia	http://purl.obolibrary.org/obo/HP_0100603	Toxemia of pregnancy		Pregnancy-induced hypertension in association with significant amounts of protein in the urine.
http://purl.obolibrary.org/obo/HP_0100603	Toxemia of pregnancy	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Pregnancy-induced toxic reactions of the mother that can be as harmless as slight Maternal hypertension or as life threatening as Eclampsia.
http://purl.obolibrary.org/obo/HP_0100604	Neoplasm of the lip	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the lip.
http://purl.obolibrary.org/obo/HP_0100606	Neoplasm of the respiratory system	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the respiratory system.
http://purl.obolibrary.org/obo/HP_0100607	Dysmenorrhea	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain during menstruation that interferes with daily activities.
http://purl.obolibrary.org/obo/HP_0100608	Metrorrhagia	http://purl.obolibrary.org/obo/HP_0000140	Abnormality of the menstrual cycle		Bleeding at irregular intervals.
http://purl.obolibrary.org/obo/HP_0100610	Maternal hyperphenylalaninemia	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		A medical history of exposure during the fetal period to hyperphenylalaninemia because the mother had phenylketonuria with inadequate control during pregnancy.
http://purl.obolibrary.org/obo/HP_0100611	Multiple glomerular cysts	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		The presence of many cysts in the glomerulus of the kidney related to dilatation of the Bowman's capsule.
http://purl.obolibrary.org/obo/HP_0100612	Odontogenic neoplasm	http://purl.obolibrary.org/obo/HP_0100649	Neoplasm of the oral cavity		Neoplasm involving odontogenic cells, an odontogenic tumor.
http://purl.obolibrary.org/obo/HP_0100613	Death in early adulthood	http://purl.obolibrary.org/obo/HP_0033763	Death in adulthood		Death between the age of 16 and 40 years.
http://purl.obolibrary.org/obo/HP_0100616	Testicular teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		The presence of a teratoma of the testis.
http://purl.obolibrary.org/obo/HP_0100617	Testicular seminoma	http://purl.obolibrary.org/obo/HP_0100620	Germinoma		The presence of a seminoma, an undifferentiated germ cell tumor of the testis.
http://purl.obolibrary.org/obo/HP_0100618	Leydig cell neoplasia	http://purl.obolibrary.org/obo/HP_0010789	Abnormality of the Leydig cells		The presence of a neoplasm of the testis with origin in a Leydig cell.
http://purl.obolibrary.org/obo/HP_0100619	Sertoli cell neoplasm	http://purl.obolibrary.org/obo/HP_0010788	Testicular neoplasm		The presence of a neoplasm of the testis with origin in a Sertoli cell.
http://purl.obolibrary.org/obo/HP_0100620	Germinoma	http://purl.obolibrary.org/obo/HP_0100728	Germ cell neoplasia		A type of undifferentiated germ cell tumor that may be benign or malignant.
http://purl.obolibrary.org/obo/HP_0100621	Dysgerminoma	http://purl.obolibrary.org/obo/HP_0100620	Germinoma		The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary.
http://purl.obolibrary.org/obo/HP_0100622	Maternal seizure	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		A seizure during pregnancy.
http://purl.obolibrary.org/obo/HP_0100623	Abnormal corpus cavernosum morphology	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		A structural anomaly of the corpus cavernosum, the erectile tissue of the penis.
http://purl.obolibrary.org/obo/HP_0100628	Esophageal diverticulum	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		The presence of a diverticulum of the esophagus.
http://purl.obolibrary.org/obo/HP_0100629	Midline facial cleft	http://purl.obolibrary.org/obo/HP_0002006	Tessier cleft		A congenital malformation with a cleft (gap or opening) in the midline of the face.
http://purl.obolibrary.org/obo/HP_0100631	Neoplasm of the adrenal gland	http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system		A tumor (abnormal growth of tissue) of the adrenal gland.
http://purl.obolibrary.org/obo/HP_0100632	Pulmonary sequestration	http://purl.obolibrary.org/obo/HP_4000059	Abnormal lung development		The presence of a piece lung tissue which is not attached to the pulmonary blood supply and does not communicate with the other lung tissue (not connected to the standard bronchial airways and not performing a function in respiration).
http://purl.obolibrary.org/obo/HP_0100633	Esophagitis	http://purl.obolibrary.org/obo/HP_0004386	Gastrointestinal inflammation		Inflammation of the esophagus.
http://purl.obolibrary.org/obo/HP_0100635	Carotid paraganglioma	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		A paraganglioma (a neuroendocrine neoplasm) originating in a carotid artery.
http://purl.obolibrary.org/obo/HP_0100636	Pulmonary paraglioma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		A rare paranglioma of the lung, tumors that arise from extra-adrenal chromaffin cells.
http://purl.obolibrary.org/obo/HP_0100638	Neoplasm of the pharynx	http://purl.obolibrary.org/obo/HP_0100630	Neoplasia of the nasopharynx		A neoplasm originating in the pharynx.
http://purl.obolibrary.org/obo/HP_0100640	Laryngeal cyst	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Presence of a cyst (sac-like structure) located in the larynx.
http://purl.obolibrary.org/obo/HP_0100641	Neoplasm of the adrenal cortex	http://purl.obolibrary.org/obo/HP_0100631	Neoplasm of the adrenal gland		The presence of a neoplasm of the adrenal cortex.
http://purl.obolibrary.org/obo/HP_0100642	Neoplasm of the adrenal medulla	http://purl.obolibrary.org/obo/HP_0100631	Neoplasm of the adrenal gland		The presence of a neoplasm of the adrenal medulla.
http://purl.obolibrary.org/obo/HP_0100644	Melanonychia	http://purl.obolibrary.org/obo/HP_0100643	Abnormality of nail color		Dark discoloration of a fingernail or toenail (brown, black, bluish and reddish).
http://purl.obolibrary.org/obo/HP_0100645	Cystocele	http://purl.obolibrary.org/obo/HP_0031607	Pelvic organ prolapse		Anterior vaginal wall prolapse with bulging of the bladder into the vagina.
http://purl.obolibrary.org/obo/HP_0100647	Graves disease	http://purl.obolibrary.org/obo/HP_0011784	Thyrotoxicosis with diffuse goiter		An autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones (a serious metabolic imbalance known as hyperthyroidism and thyrotoxicosis). This is caused by autoantibodies to the TSH-receptor (TSHR-Ab) that activate that TSH-receptor (TSHR), thereby stimulating thyroid hormone synthesis and secretion, and thyroid growth (causing a diffusely enlarged goiter). The resulting state of hyperthyroidism can cause a dramatic constellation of neuropsychological and physical signs and symptoms, which can severely compromise the patients.
http://purl.obolibrary.org/obo/HP_0100648	Neoplasm of the tongue	http://purl.obolibrary.org/obo/HP_0100649	Neoplasm of the oral cavity		A tumor (abnormal growth of tissue) of the tongue.
http://purl.obolibrary.org/obo/HP_0100649	Neoplasm of the oral cavity	http://purl.obolibrary.org/obo/HP_0034930	Digestive system neoplasm		A tumor (abnormal growth of tissue) of the oral cavity.
http://purl.obolibrary.org/obo/HP_0100650	Vaginal neoplasm	http://purl.obolibrary.org/obo/HP_0033020	Female reproductive system neoplasm		A tumor (abnormal growth of tissue) of the vagina.
http://purl.obolibrary.org/obo/HP_0100651	Type I diabetes mellitus	http://purl.obolibrary.org/obo/HP_0000819	Diabetes mellitus		A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin.
http://purl.obolibrary.org/obo/HP_0100653	Optic neuritis	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		Inflammation of the optic nerve.
http://purl.obolibrary.org/obo/HP_0100654	Retrobulbar optic neuritis	http://purl.obolibrary.org/obo/HP_0100653	Optic neuritis		Optic neuritis that occurs in the section of the optic nerve located behind the eyeball.
http://purl.obolibrary.org/obo/HP_0100656	Thoracoabdominal wall defect	http://purl.obolibrary.org/obo/HP_0010866	Abdominal wall defect		Failure of the chest and abdominal wall to close, which is likely caused by the failure of the ventral wall to close during week 4 of development.
http://purl.obolibrary.org/obo/HP_0100657	Thoracoabdominal eventration	http://purl.obolibrary.org/obo/HP_0100656	Thoracoabdominal wall defect		Congenital protrusion of the abdominal or thoracic viscera, usually with a defect of the sternum and ribs as well as of the abdominal walls.
http://purl.obolibrary.org/obo/HP_0100661	Trigeminal neuralgia	http://purl.obolibrary.org/obo/HP_0033345	Neuralgia		A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.
http://purl.obolibrary.org/obo/HP_0100662	Chondritis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of cartilage.
http://purl.obolibrary.org/obo/HP_0100663	Synotia	http://purl.obolibrary.org/obo/HP_0000357	Abnormal location of ears		A congenital malformation characterized by the union or approximation of the ears in front of the neck, often accompanied by the absence or defective development of the lower jaw.
http://purl.obolibrary.org/obo/HP_0100665	Angioedema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis.
http://purl.obolibrary.org/obo/HP_0100668	Intestinal duplication	http://purl.obolibrary.org/obo/HP_0011140	Gastrointestinal duplication		A developmental disorder in which there is a duplication the entire intestine or of a portion of the intestine.
http://purl.obolibrary.org/obo/HP_0100669	Abnormal pigmentation of the oral mucosa	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		An abnormality of the pigmentation of the mucosa of the mouth.
http://purl.obolibrary.org/obo/HP_0100670	Coarse metaphyseal trabecularization	http://purl.obolibrary.org/obo/HP_0100671	Abnormal trabecular bone morphology		Coarse appearance of the components of the network of osseous tissue that makes up the cancellous structure of a bone, i.e., thickening of the (usually fine) white lines that are produced by trabeculae in radiograms.
http://purl.obolibrary.org/obo/HP_0100673	Vaginal hydrocele	http://purl.obolibrary.org/obo/HP_0000034	Hydrocele testis		A type of hydrocele testis in which the processus vaginalis remains patent only around the testes, and, as fluid accumulates, it renders the testes impalpable.
http://purl.obolibrary.org/obo/HP_0100677	Vulval varicose vein	http://purl.obolibrary.org/obo/HP_0002619	Varicose veins		Varicosity of veins in the vulval region.
http://purl.obolibrary.org/obo/HP_0100681	Esophageal duplication	http://purl.obolibrary.org/obo/HP_0011140	Gastrointestinal duplication		A developmental disorder in which there is a duplication of a portion of the muscle and submucosa of the esophagus without epithelial duplication.
http://purl.obolibrary.org/obo/HP_0100682	Tracheal atresia	http://purl.obolibrary.org/obo/HP_0002777	Tracheal stenosis		A congenital absence or considerable underdevelopment of the trachea such that communication between the larynx proximally and the alveoli of the lungs distally is lacking.
http://purl.obolibrary.org/obo/HP_0100684	Salivary gland neoplasm	http://purl.obolibrary.org/obo/HP_0100649	Neoplasm of the oral cavity		A tumor (abnormal growth of tissue) of a salivary gland.
http://purl.obolibrary.org/obo/HP_0100687	Polyotia	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		The presence of an extra auricle on one or both sides of the head.
http://purl.obolibrary.org/obo/HP_0100693	Iridodonesis	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		Tremulousness of the iris on movement of the eye, occurring in subluxation of the lens.
http://purl.obolibrary.org/obo/HP_0100694	Tibial torsion	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		Twisted position of the tibia (shin bone) associated with pathological rotation of the leg.
http://purl.obolibrary.org/obo/HP_0100695	Lipedema	http://purl.obolibrary.org/obo/HP_0009126	Increased adipose tissue		Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise .
http://purl.obolibrary.org/obo/HP_0100697	Malignant peripheral nerve sheath tumor	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas (STS) with nerve sheath differentiation and a tendency to metastasize.
http://purl.obolibrary.org/obo/HP_0100698	Subcutaneous neurofibroma	http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location		A neurofibroma (benign peripheral nerve sheath tumor) localized in the subcutis (subcutaneous region).
http://purl.obolibrary.org/obo/HP_0100700	Abnormal arachnoid mater morphology	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		An abnormality of the Arachnoid mater.
http://purl.obolibrary.org/obo/HP_0100701	Abnormal pia mater	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		An abnormality of the pia mater.
http://purl.obolibrary.org/obo/HP_0100702	Arachnoid cyst	http://purl.obolibrary.org/obo/HP_0100700	Abnormal arachnoid mater morphology		An extra-parenchymal and intra-arachnoidal collection of fluid with a composition similar to that of cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0100703	Tongue thrusting	http://purl.obolibrary.org/obo/HP_5200017	Stereotypic movements of face and head		Pressing forward of the tongue in the mouth, a retained motoric habit from infantile swallowing patterns
http://purl.obolibrary.org/obo/HP_0100704	Cerebral visual impairment	http://purl.obolibrary.org/obo/HP_0000505	Visual impairment		A form of loss of vision caused by damage to the visual cortex rather than a defect in the eye.
http://purl.obolibrary.org/obo/HP_0100706	Abnormal oligodendroglia morphology	http://purl.obolibrary.org/obo/HP_0100705	Abnormal glial cell morphology		One of the three types of glia cells that, with the nerve cells, compose the central nervous system and are characterized by sheetlike processes that wrap around individual axons to form the myelin sheath of nerve fibers.
http://purl.obolibrary.org/obo/HP_0100707	Abnormal astrocyte morphology	http://purl.obolibrary.org/obo/HP_0100705	Abnormal glial cell morphology		An abnormality of astrocytes.
http://purl.obolibrary.org/obo/HP_0100708	Abnormal microglia morphology	http://purl.obolibrary.org/obo/HP_0100705	Abnormal glial cell morphology		An abnormality of the microglial cells. They are also known as brain-resident macrophages or Hortega cells.
http://purl.obolibrary.org/obo/HP_0100710	Impulsivity	http://purl.obolibrary.org/obo/HP_0000734	Disinhibition		Acting on the spur of the moment or on a momentary basis without consideration of outcomes; having difficulty establishing or following plans; experiencing a sense of urgency and engaging in behavior that is uninhibited, cannot be inhibited, and is uncontrolled. The possibility of repression is inconceivable.
http://purl.obolibrary.org/obo/HP_0100712	Abnormal lumbar spine morphology	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Any structural abnormality of the lumbar vertebral column.
http://purl.obolibrary.org/obo/HP_0100717	Abnormal cementum morphology	http://purl.obolibrary.org/obo/HP_3000050	Abnormal odontoid tissue morphology		Any structural anomaly of the cementum, which is the mineralized connective tissue covering the dental root. The cementum allows anchoring of the fibers of the periodontal ligament. Cementum is secreted by cementoblasts, which may be, later on, embedded in the cementum. Cementum can be acellular (along the two third coronal portion of the root) and cellular (in the apical and interradicular part of the root).
http://purl.obolibrary.org/obo/HP_0100719	Lens coloboma	http://purl.obolibrary.org/obo/HP_0008063	Aplasia/Hypoplasia of the lens		A sectoral indentation of the crystalline lens, usually due to zonular weakness or absence.
http://purl.obolibrary.org/obo/HP_0100721	Mediastinal lymphadenopathy	http://purl.obolibrary.org/obo/HP_0045026	Abnormal mediastinum morphology		Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes.
http://purl.obolibrary.org/obo/HP_0100724	Hypercoagulability	http://purl.obolibrary.org/obo/HP_0001928	Abnormality of coagulation		An abnormality of coagulation associated with an increased risk of thrombosis.
http://purl.obolibrary.org/obo/HP_0100725	Lichenification	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Thickening and hardening of the epidermis seen with exaggeration of normal skin lines.
http://purl.obolibrary.org/obo/HP_0100726	Kaposi's sarcoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		A systemic disease which can present with cutaneous lesions with or without internal involvement. Tumors are caused by Human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV).
http://purl.obolibrary.org/obo/HP_0100727	Histiocytosis	http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology		An excessive number of histiocytes (tissue macrophages).
http://purl.obolibrary.org/obo/HP_0100730	Bronchogenic cyst	http://purl.obolibrary.org/obo/HP_0032445	Pulmonary cyst		A rare congenital cystic lesion of the lungs in the mediastinum.
http://purl.obolibrary.org/obo/HP_0100731	Transverse facial cleft	http://purl.obolibrary.org/obo/HP_0011338	Abnormality of mouth shape		A horizontal cleft of the face, varying from slight widening of the mouth, to a cleft extending to the ear.
http://purl.obolibrary.org/obo/HP_0100734	Abnormal vertebral epiphysis morphology	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		An anomaly of one or more epiphyses of one or more vertebrae.
http://purl.obolibrary.org/obo/HP_0100739	Bulimia	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		A form of anomalous eating behavior characterized by binge eating is followed by self-induced vomiting or other compensatory behavior intended to prevent weight gain (purging, fasting or exercising or a combination of these).
http://purl.obolibrary.org/obo/HP_0100746	Macrodactyly of finger	http://purl.obolibrary.org/obo/HP_0004099	Macrodactyly		A type of Macrodactyly affecting one or several fingers.
http://purl.obolibrary.org/obo/HP_0100747	Macrodactyly of toe	http://purl.obolibrary.org/obo/HP_0004099	Macrodactyly		A type of Macrodactyly affecting one or several toes.
http://purl.obolibrary.org/obo/HP_0100749	Chest pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
http://purl.obolibrary.org/obo/HP_0100750	Atelectasis	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Collapse of part of a lung associated with absence of inflation (air) of that part.
http://purl.obolibrary.org/obo/HP_0100751	Esophageal neoplasm	http://purl.obolibrary.org/obo/HP_0012288	Neoplasm of head and neck		A tumor (abnormal growth of tissue) of the esophagus.
http://purl.obolibrary.org/obo/HP_0100752	Abnormal liver lobulation	http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology		Formation of abnormal lobules (small masses of tissue) in the liver.
http://purl.obolibrary.org/obo/HP_0100753	Schizophrenia	http://purl.obolibrary.org/obo/HP_0025783	Diagnostic behavioral phenotype		A mental disorder characterized by a disintegration of thought processes and emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking. It is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 1%. This term is not a helpful parent term to describe abnormal experiences.
http://purl.obolibrary.org/obo/HP_0100754	Mania	http://purl.obolibrary.org/obo/HP_5200263	Abnormally increased volition		A state of abnormally elevated or irritable mood, arousal, and/or energy levels.
http://purl.obolibrary.org/obo/HP_0100757	Pancreatoblastoma	http://purl.obolibrary.org/obo/HP_0002894	Neoplasm of the pancreas		A rare pediatric carcinoma of the pancreas.
http://purl.obolibrary.org/obo/HP_0100758	Gangrene	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).
http://purl.obolibrary.org/obo/HP_0100759	Clubbing of fingers	http://purl.obolibrary.org/obo/HP_0001217	Clubbing		Terminal broadening of the fingers (distal phalanges of the fingers).
http://purl.obolibrary.org/obo/HP_0100760	Clubbing of toes	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		Terminal broadening of the toes (distal phalanges of the toes).
http://purl.obolibrary.org/obo/HP_0100762	Hemobilia	http://purl.obolibrary.org/obo/HP_0012439	Abnormal biliary tract physiology		Bleeding into the biliary tree.
http://purl.obolibrary.org/obo/HP_0100764	Lymphangioma	http://purl.obolibrary.org/obo/HP_0100763	Abnormality of the lymphatic system		Lymphangiomas are rare congenital malformations consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures. Lymphangioma is usually asymptomatic due to its soft consistency but compression of adjacent structures can be seen due to the mass effect of a large tumor.
http://purl.obolibrary.org/obo/HP_0100765	Abnormality of the tonsils	http://purl.obolibrary.org/obo/HP_0100763	Abnormality of the lymphatic system		An abnormality of the tonsils.
http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology	http://purl.obolibrary.org/obo/HP_0001194	Abnormalities of placenta or umbilical cord		An abnormality of the placenta, the organ that connects the developing fetus to the uterine wall to enable nutrient uptake, waste elimination, and gas exchange.
http://purl.obolibrary.org/obo/HP_0100768	Choriocarcinoma	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		A malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs and belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors.
http://purl.obolibrary.org/obo/HP_0100770	Hyperperistalsis	http://purl.obolibrary.org/obo/HP_0030914	Abnormal peristalsis		Excessively active peristalsis (wave of contraction of the tubular organs of the gastrointestinal tract) marked by excessive rapidity of the passage of food through the stomach and intestine.
http://purl.obolibrary.org/obo/HP_0100771	Hypoperistalsis	http://purl.obolibrary.org/obo/HP_0030914	Abnormal peristalsis		Reduced or inadequate peristalsis, with resultant slow passage of contents through the digestive tract.
http://purl.obolibrary.org/obo/HP_0100775	Dural ectasia	http://purl.obolibrary.org/obo/HP_0010303	Abnormal spinal meningeal morphology		A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level.
http://purl.obolibrary.org/obo/HP_0100776	Recurrent pharyngitis	http://purl.obolibrary.org/obo/HP_0020343	Unusual pharyngitis		Increased susceptibility to pharyngitis, as manifested by recurrent episodes of pharyngeal infection that are unusual in frequency or severity for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_0100778	Cryoglobulinemia	http://purl.obolibrary.org/obo/HP_0005368	Abnormality of humoral immunity		Increased level of cryoglobulins in the blood. Cryoglobulins are abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when serum is cooled below 37 degrees Celsius.
http://purl.obolibrary.org/obo/HP_0100779	Urogenital sinus anomaly	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		A rare birth defect in women where the urethra and vagina both open into a common channel.
http://purl.obolibrary.org/obo/HP_0100780	Conjunctival hamartoma	http://purl.obolibrary.org/obo/HP_0010568	Hamartoma of the eye		A hamartoma (disordered proliferation of mature tissues) of the conjunctiva.
http://purl.obolibrary.org/obo/HP_0100781	Abnormal sacroiliac joint morphology	http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology		An anomaly of the sacroiliac joint, which connects the base of the spine (sacrum) to the ilium (a hip bone).
http://purl.obolibrary.org/obo/HP_0100783	Breast aplasia	http://purl.obolibrary.org/obo/HP_0010311	Aplasia/Hypoplasia of the breasts		Failure to develop and congenital absence of the breast.
http://purl.obolibrary.org/obo/HP_0100788	Fused lips	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Lack of separation of the upper and lower lips.
http://purl.obolibrary.org/obo/HP_0100789	Torus palatinus	http://purl.obolibrary.org/obo/HP_0100737	Abnormal hard palate morphology		A bony protrusion present on the midline of the hard palate.
http://purl.obolibrary.org/obo/HP_0100792	Acantholysis	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.
http://purl.obolibrary.org/obo/HP_0100795	Abnormally straight spine	http://purl.obolibrary.org/obo/HP_0010674	Abnormal curvature of the vertebral column		The absence of the normal curvature of the vertebral column.
http://purl.obolibrary.org/obo/HP_0100796	Orchitis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Testicular inflammation.
http://purl.obolibrary.org/obo/HP_0100797	Toenail dysplasia	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		An abnormality of the development of the toenails.
http://purl.obolibrary.org/obo/HP_0100798	Fingernail dysplasia	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		An abnormality of the development of the fingernails.
http://purl.obolibrary.org/obo/HP_0100799	Neoplasm of the middle ear	http://purl.obolibrary.org/obo/HP_0012780	Neoplasm of the ear		A tumor (abnormal growth of tissue) of the middle ear.
http://purl.obolibrary.org/obo/HP_0100801	Pancreatic aplasia	http://purl.obolibrary.org/obo/HP_0100800	Aplasia/Hypoplasia of the pancreas		Aplasia of the pancreas.
http://purl.obolibrary.org/obo/HP_0100802	Malposition of the stomach	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		Abnormal anatomical location of the stomach. This feature may be due to intestinal malrotation.
http://purl.obolibrary.org/obo/HP_0100804	Ungual fibroma	http://purl.obolibrary.org/obo/HP_0100826	Neoplasm of the nail		Flesh-colored papule in or around the nail bed. Ungual fibromas may be periungual (arising under the proximal nail fold) or subungual (originating under the nail plate).
http://purl.obolibrary.org/obo/HP_0100808	Gastric diverticulum	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		An outpouching of the gastric wall.
http://purl.obolibrary.org/obo/HP_0100809	Scalp tenderness	http://purl.obolibrary.org/obo/HP_0001965	Abnormal scalp morphology		Pain or discomfort of the scalp elicited by palpation.
http://purl.obolibrary.org/obo/HP_0100811	Aplasia/Hypoplasia of the colon	http://purl.obolibrary.org/obo/HP_0005245	Intestinal hypoplasia		Congenital absence or underdevelopment of the colon.
http://purl.obolibrary.org/obo/HP_0100812	Halitosis	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Noticeably unpleasant odors exhaled in breathing.
http://purl.obolibrary.org/obo/HP_0100813	Testicular torsion	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Testicular torsion is when the spermatic cord to a testicle twists, cutting off the blood supply. The most common symptom is acute testicular pain.
http://purl.obolibrary.org/obo/HP_0100814	Blue nevus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		A solitary, bluish, smooth surfaced macule, papule or plaque that is generally round or oval in shape. The histopathology of blue nevi varies by subtype, but general characteristics include a vertical wedge or bulbous shaped proliferation of spindle cells, dendritic melanocytes, and melanophages into a sclerotic dermis or subcutis.
http://purl.obolibrary.org/obo/HP_0100817	Renovascular hypertension	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		The presence of hypertension related to stenosis of the renal artery.
http://purl.obolibrary.org/obo/HP_0100818	Long thorax	http://purl.obolibrary.org/obo/HP_0100625	Enlarged thorax		Increased inferior to superior extent of the thorax.
http://purl.obolibrary.org/obo/HP_0100819	Intestinal fistula	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		An abnormal connection between the gut and another hollow organ, such as the bladder, urethra, vagina, or other regions of the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0100820	Glomerulopathy	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron.
http://purl.obolibrary.org/obo/HP_0100821	Urethrocele	http://purl.obolibrary.org/obo/HP_0031607	Pelvic organ prolapse		The prolapse of the female urethra into the vagina.
http://purl.obolibrary.org/obo/HP_0100822	Rectocele	http://purl.obolibrary.org/obo/HP_0031607	Pelvic organ prolapse		A Rectocele results from a tear in the rectovaginal septum (which is normally a tough, fibrous, sheet-like divider between the rectum and vagina). Rectal tissue bulges through this tear and into the vagina as a hernia. There are two main causes of this tear: childbirth, and hysterectomy.
http://purl.obolibrary.org/obo/HP_0100825	Cheilitis	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Inflammation of the lip.
http://purl.obolibrary.org/obo/HP_0100826	Neoplasm of the nail	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the nail.
http://purl.obolibrary.org/obo/HP_0100827	Increased total lymphocyte count	http://purl.obolibrary.org/obo/HP_0040088	Abnormal lymphocyte count		Increase in the number or proportion of lymphocytes in the blood.
http://purl.obolibrary.org/obo/HP_0100829	Galactorrhea	http://purl.obolibrary.org/obo/HP_0031094	Abnormal breast physiology		Spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
http://purl.obolibrary.org/obo/HP_0100831	Abnormal circulating vitamin K concentration	http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration		The concentration of vitamin K in the blood circulation is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0100832	Vitreous floaters	http://purl.obolibrary.org/obo/HP_6001103	Entoptic phenomenon		Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humor, which is normally transparent.
http://purl.obolibrary.org/obo/HP_0100833	Neoplasm of the small intestine	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		The presence of a neoplasm of the small intestine.
http://purl.obolibrary.org/obo/HP_0100834	Neoplasm of the large intestine	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		The presence of a neoplasm of the large intestine.
http://purl.obolibrary.org/obo/HP_0100837	Atrophodermia vermiculata	http://purl.obolibrary.org/obo/HP_0011799	Abnormality of facial soft tissue		Symmetrical vermiform facial atrophy that affects mainly the forehead, the chin, the ear lobes and helices. Atrophodermia vermiculata is characterized by erythema and follicular plugs on the cheeks, developing into painless reticular impressions.
http://purl.obolibrary.org/obo/HP_0100838	Recurrent cutaneous abscess formation	http://purl.obolibrary.org/obo/HP_0005406	Recurrent bacterial skin infections		An increased susceptibility to cutaneous abscess formation, as manifested by a medical history of recurrent cutaneous abscesses.
http://purl.obolibrary.org/obo/HP_0100839	Hepatic agenesis	http://purl.obolibrary.org/obo/HP_0034181	Aplasia/Hypoplasia of the liver		Absence of the liver owing to a failure of the liver to develop.
http://purl.obolibrary.org/obo/HP_0100841	Microgastria	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		A developmental anomaly with a small tubular or saccular midline stomach.
http://purl.obolibrary.org/obo/HP_0100842	Septo-optic dysplasia	http://purl.obolibrary.org/obo/HP_0001331	Absent septum pellucidum		Underdevelopment of the optic nerve and absence of the septum pellucidum.
http://purl.obolibrary.org/obo/HP_0100847	Palmoplantar pustulosis	http://purl.obolibrary.org/obo/HP_0200039	Pustule		A chronic, relapsing, pustular eruption that is localized to the palms and soles.
http://purl.obolibrary.org/obo/HP_0100848	Neoplasm of the male external genitalia	http://purl.obolibrary.org/obo/HP_0033019	Male reproductive system neoplasm		A tumor (abnormal growth of tissue) of the male external genitalia.
http://purl.obolibrary.org/obo/HP_0100849	Neoplasm of the scrotum	http://purl.obolibrary.org/obo/HP_0100848	Neoplasm of the male external genitalia		A tumor (abnormal growth of tissue) of the scrotum.
http://purl.obolibrary.org/obo/HP_0100850	Neoplasm of the penis	http://purl.obolibrary.org/obo/HP_0100848	Neoplasm of the male external genitalia		A tumor (abnormal growth of tissue) of the penis.
http://purl.obolibrary.org/obo/HP_0100853	Hypoplastic areola	http://purl.obolibrary.org/obo/HP_0032314	Abnormal areolar morphology		Underdevelopment of the areola, the circular area of pigmented skin surrounding the nipple.
http://purl.obolibrary.org/obo/HP_0100855	Triceps hypoplasia	http://purl.obolibrary.org/obo/HP_0009784	Aplasia/Hypoplasia of the triceps		Hypoplasia of the triceps muscle.
http://purl.obolibrary.org/obo/HP_0100856	Poorly ossified vertebrae	http://purl.obolibrary.org/obo/HP_0004599	Absent or minimally ossified vertebral bodies		Decreased ossification of the vertebral bodies.
http://purl.obolibrary.org/obo/HP_0100857	Flat sella turcica	http://purl.obolibrary.org/obo/HP_0002681	Deformed sella turcica		An abnormally flat sella turcica.
http://purl.obolibrary.org/obo/HP_0100858	Dilatation of celiac artery	http://purl.obolibrary.org/obo/HP_0002636	Dilatation of an abdominal artery		Abnormal outpouching or sac-like dilatation in the wall of the celiac artery.
http://purl.obolibrary.org/obo/HP_0100859	Dilatation of superior mesenteric artery	http://purl.obolibrary.org/obo/HP_0011934	Dilatation of mesenteric artery		Abnormal outpouching or sac-like dilatation in the wall of the superior mesenteric artery .
http://purl.obolibrary.org/obo/HP_0100860	Dilatation of Inferior mesenteric artery	http://purl.obolibrary.org/obo/HP_0011934	Dilatation of mesenteric artery		Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery .
http://purl.obolibrary.org/obo/HP_0100861	Sclerotic vertebral body	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		Increase in bone density of the vertebral body.
http://purl.obolibrary.org/obo/HP_0100864	Short femoral neck	http://purl.obolibrary.org/obo/HP_0009108	Aplasia/Hypoplasia involving the femoral head and neck		An abnormally short femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).
http://purl.obolibrary.org/obo/HP_0100865	Broad ischia	http://purl.obolibrary.org/obo/HP_0003174	Abnormal ischium morphology		Increased width of the ischium, which forms the lower and back part of the hip bone.
http://purl.obolibrary.org/obo/HP_0100866	Short iliac bones	http://purl.obolibrary.org/obo/HP_0000946	Hypoplastic ilia		Underdevelopment of the iliac bones.
http://purl.obolibrary.org/obo/HP_0100867	Duodenal stenosis	http://purl.obolibrary.org/obo/HP_0012848	Small intestinal stenosis		The narrowing or partial blockage of a portion of the duodenum.
http://purl.obolibrary.org/obo/HP_0100869	Palmar telangiectasia	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		The presence of telangiectases on the skin of palm of hand.
http://purl.obolibrary.org/obo/HP_0100870	Plantar telangiectasia	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		Telangiectases (small dilated blood vessels) located on the skin of sole of foot.
http://purl.obolibrary.org/obo/HP_0100874	Thick hair	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		Increased density of hairs, i.e., and elevated number of hairs per unit area.
http://purl.obolibrary.org/obo/HP_0100875	Hemimacroglossia	http://purl.obolibrary.org/obo/HP_0000158	Macroglossia		Increased length and width of one half of the tongue.
http://purl.obolibrary.org/obo/HP_0100876	Infra-orbital crease	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Skin crease extending from below the inner canthus laterally along the malar process of the maxilla and zygoma.
http://purl.obolibrary.org/obo/HP_0100877	Renal diverticulum	http://purl.obolibrary.org/obo/HP_0004742	Abnormal renal collecting system morphology		Cystic, urine-containing intrarenal cavities lined with transitional cell epithelium that communicate through a narrow channel with the collecting system.
http://purl.obolibrary.org/obo/HP_0100880	Nephrogenic rest	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Abnormally persistent clusters of embryonal cells, representing microscopic malformations (dysplasias) of the developing kidney.
http://purl.obolibrary.org/obo/HP_0100881	Congenital mesoblastic nephroma	http://purl.obolibrary.org/obo/HP_0011794	Embryonal renal neoplasm		Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue.
http://purl.obolibrary.org/obo/HP_0100882	Fibrous hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A rare, benign soft tissue tumor that typically occurs within the first two years of life.
http://purl.obolibrary.org/obo/HP_0100883	Chorangioma	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Hamartoma-like growth in the placenta consisting of blood vessels.
http://purl.obolibrary.org/obo/HP_0100884	Compensatory scoliosis	http://purl.obolibrary.org/obo/HP_0002650	Scoliosis		A scoliosis which is the results of a difference in leg length (which might be due to hemihypertrophy or hemihypotrophy of a leg) and the resulting tilting of the pelvis. If untreated this will lead to the development of scoliosis over time.
http://purl.obolibrary.org/obo/HP_0100885	Lateral venous anomaly	http://purl.obolibrary.org/obo/HP_0001015	Prominent superficial veins		Persistence of the embryonic dorsal or sciatic vein system that normally should have involuted around the tenth to twelfth week of intrauterine life.
http://purl.obolibrary.org/obo/HP_0100889	Abnormal ductus choledochus morphology	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		An abnormality of the Common bile duct, a tube-like anatomic structure in the human gastrointestinal tract, formed by the union of the Common hepatic duct and the Cystic duct from the gall bladder.
http://purl.obolibrary.org/obo/HP_0100891	Bifid xiphoid process	http://purl.obolibrary.org/obo/HP_0100892	Abnormality of the xiphoid process		A cleft of the xiphoid process of the sternum.
http://purl.obolibrary.org/obo/HP_0100892	Abnormality of the xiphoid process	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		An abnormality of the xiphoid process of the sternum.
http://purl.obolibrary.org/obo/HP_0100893	Prominent xiphoid process	http://purl.obolibrary.org/obo/HP_0100892	Abnormality of the xiphoid process		Increased prominence of the xiphoid process of the sternum.
http://purl.obolibrary.org/obo/HP_0100894	Broad xiphoid process	http://purl.obolibrary.org/obo/HP_0100892	Abnormality of the xiphoid process		Increased side-to-side width of the xiphoid process of the sternum.
http://purl.obolibrary.org/obo/HP_0100896	Rectal polyposis	http://purl.obolibrary.org/obo/HP_0100743	Neoplasm of the rectum		The presence of multiple rectal hyperplastic/adenomatous polyps.
http://purl.obolibrary.org/obo/HP_0100898	Connective tissue nevi	http://purl.obolibrary.org/obo/HP_0003764	Nevus		Connective tissue nevi are hamartomas in which one or several components of the dermis is altered.
http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		An elevation in bone density in one or more phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100912	Sclerosis of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0100922	Sclerosis of thumb phalanx		An elevation of bone density in the distal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0100913	Sclerosis of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0100922	Sclerosis of thumb phalanx		An elevation of bone density in the proximal phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0100915	Sclerosis of distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		An elevation in bone density in one or more distal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100916	Sclerosis of middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		An elevation in bone density in one or more middle phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100917	Sclerosis of proximal phalanx of finger	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		An elevation in bone density in one or more proximal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100918	Sclerosis of 2nd finger phalanx	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		An elevation in bone density in one or more phalanges of the second finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100919	Sclerosis of 3rd finger phalanx	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		An elevation in bone density in one or more phalanges of the third finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100920	Sclerosis of 4th finger phalanx	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		An elevation in bone density in one or more phalanges of the fourth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100921	Sclerosis of 5th finger phalanx	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		An elevation in bone density in one or more phalanges of the fifth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100923	Clavicular sclerosis	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		An increase in bone density within the clavicle.
http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx	http://purl.obolibrary.org/obo/HP_0100925	Sclerosis of foot bone		An elevation in bone density in one or more phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100925	Sclerosis of foot bone	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		An elevation in bone density in one or more foot bones. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100926	Sclerosis of 2nd toe phalanx	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more phalanges of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100927	Sclerosis of 3rd toe phalanx	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more phalanges of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100928	Sclerosis of 4th toe phalanx	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more phalanges of the fourth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100929	Sclerosis of 5th toe phalanx	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more phalanges of the fifth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100930	Sclerosis of hallux phalanx	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more phalanges of the big toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100931	Sclerosis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100946	Sclerosis of proximal phalanx of toe		An elevation in bone density in the proximal phalanx of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100932	Sclerosis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100946	Sclerosis of proximal phalanx of toe		An elevation in bone density in the proximal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100936	Sclerosis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100947	Sclerosis of middle phalanx of toe		An elevation in bone density in the middle phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100940	Sclerosis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100948	Sclerosis of distal phalanx of toe		An elevation in bone density in the distal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100946	Sclerosis of proximal phalanx of toe	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more proximal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100947	Sclerosis of middle phalanx of toe	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more middle phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100948	Sclerosis of distal phalanx of toe	http://purl.obolibrary.org/obo/HP_0100924	Sclerosis of toe phalanx		An elevation in bone density in one or more distal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.
http://purl.obolibrary.org/obo/HP_0100952	Enlarged sylvian cistern	http://purl.obolibrary.org/obo/HP_0002119	Ventriculomegaly		An increase in size of the subarachnoid space associated with the lateral cerebral sulcus (Sylvian fissure).
http://purl.obolibrary.org/obo/HP_0100954	Open operculum	http://purl.obolibrary.org/obo/HP_0006872	Cerebral hypoplasia		Underdevelopment of the operculum.
http://purl.obolibrary.org/obo/HP_0100958	Narrow foramen obturatorium	http://purl.obolibrary.org/obo/HP_0003174	Abnormal ischium morphology		Decreased width of the foramen obturatorium. The foramen obturatorium (also known as the obturator foramen) is a hole located between the ischium and pubis bones of the pelvis.
http://purl.obolibrary.org/obo/HP_0100959	Dense metaphyseal bands	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Dense radiopaque bands of bone which are thicker than the adjacent diaphyseal cortex and may form at the metaphysis of growing bones. They appear on radiographs as bone that is more radiopaque that the adjacent diaphyseal cortex.
http://purl.obolibrary.org/obo/HP_0100960	Lateral ventricular asymmetry	http://purl.obolibrary.org/obo/HP_0002118	Abnormal cerebral ventricle morphology		Abnormal difference in size between the left and right lateral cerebral ventricles.
http://purl.obolibrary.org/obo/HP_0100961	Enlarged hippocampus	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		Increase in size of the hippocampus.
http://purl.obolibrary.org/obo/HP_0100962	Excessive shyness	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		Atypically high degree of awkwardness or apprehension experienced when approaching or being approached by others.
http://purl.obolibrary.org/obo/HP_0200000	Dysharmonic skeletal maturation	http://purl.obolibrary.org/obo/HP_0000927	Abnormality of skeletal maturation		Different levels of maturation of different bones.
http://purl.obolibrary.org/obo/HP_0200001	Dysharmonic accelerated bone age	http://purl.obolibrary.org/obo/HP_0200000	Dysharmonic skeletal maturation		A type of dysharmonic skeletal maturation in which there is an acceleration in skeletal maturation whose degree differs markedly in different bones.
http://purl.obolibrary.org/obo/HP_0200003	Splayed epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		Flaring (widening) of the epiphysis.
http://purl.obolibrary.org/obo/HP_0200005	Abnormal shape of the palpebral fissure	http://purl.obolibrary.org/obo/HP_0008050	Abnormality of the palpebral fissures		The presence of an abnormal shape of the palpebral fissure.
http://purl.obolibrary.org/obo/HP_0200008	Intestinal polyposis	http://purl.obolibrary.org/obo/HP_0005266	Intestinal polyp		The presence of multiple polyps in the intestine.
http://purl.obolibrary.org/obo/HP_0200013	Neoplasm of fatty tissue	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of adipose tissue.
http://purl.obolibrary.org/obo/HP_0200016	Acrokeratosis	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		Overgrowth of the stratum corneum characterized by flesh-coloured or slightly pigmented smooth or warty papules on the upper surface of hands and feet.
http://purl.obolibrary.org/obo/HP_0200017	Cerebral white matter agenesis	http://purl.obolibrary.org/obo/HP_0012429	Aplasia/Hypoplasia of the cerebral white matter		Congenital defect with failure of the development of the cerebral white matter.
http://purl.obolibrary.org/obo/HP_0200018	Protanomaly	http://purl.obolibrary.org/obo/HP_0011519	Anomalous trichromacy		A type of anomalous trichromacy associated with defective long-wavelength-sensitive (L) cones, causing the sensitivity spectrum to be shifted toward medium wavelengths. This leads to difficulties especially in distinguishing red and green.
http://purl.obolibrary.org/obo/HP_0200021	Down-sloping shoulders	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		Low set, steeply sloping shoulders.
http://purl.obolibrary.org/obo/HP_0200022	Choroid plexus papilloma	http://purl.obolibrary.org/obo/HP_0012740	Papilloma		Choroid plexus papilloma is a histologically benign neoplasm located in the ventricular system of the choroid plexus.
http://purl.obolibrary.org/obo/HP_0200023	Priapism	http://purl.obolibrary.org/obo/HP_0100639	Erectile dysfunction		A painful and harmful medical condition in which the erect penis doesn't return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours.
http://purl.obolibrary.org/obo/HP_0200025	Mandibular pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the mandible.
http://purl.obolibrary.org/obo/HP_0200026	Ocular pain	http://purl.obolibrary.org/obo/HP_0046506	Pain in head and neck region		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.
http://purl.obolibrary.org/obo/HP_0200028	Pretibial myxedema	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		A diffuse, non-pitting edema and thickening of the skin usually on the anterior aspect of the lower legs spreading to the dorsum of the feet.
http://purl.obolibrary.org/obo/HP_0200029	Vasculitis in the skin	http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site		A type of vasculitis (inflammation of blood vessel walls) that affects skeletal muscle tissue.
http://purl.obolibrary.org/obo/HP_0200032	Kayser-Fleischer ring	http://purl.obolibrary.org/obo/HP_0007957	Corneal opacity		Grey-green or brownish-pigmented ring in the deep epithelial layers at the outer border of the cornea.
http://purl.obolibrary.org/obo/HP_0200034	Papule	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point.
http://purl.obolibrary.org/obo/HP_0200035	Skin plaque	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter.
http://purl.obolibrary.org/obo/HP_0200037	Skin vesicle	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A circumscribed, fluid-containing, epidermal elevation less than 10mm in diameter at the widest point that (i) Contain serous exudates or serum mixed with blood or pus; (ii) Are discrete, grouped, irregularly distributed, or linear as in Rhus dermatitis; (iii) Are short-lived. Vesicles may break spontaneously or evolve into bullae by enlarging or coalescing with other vesicles.
http://purl.obolibrary.org/obo/HP_0200039	Pustule	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		A small elevation of the skin containing cloudy or purulent material usually consisting of necrotic inflammatory cells.
http://purl.obolibrary.org/obo/HP_0200040	Epidermoid cyst	http://purl.obolibrary.org/obo/HP_0025245	Cutaneous cyst		Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Epidermal cysts are intradermal or subcutaneous tumors, grow slowly and occur on the face, neck, back and scrotum. They usually appear at or around puberty, and as a rule an affected individual has one solitary or a few cysts. A central, dark comedone opening (punctum) may be present.
http://purl.obolibrary.org/obo/HP_0200041	Skin erosion	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed.
http://purl.obolibrary.org/obo/HP_0200043	Verrucae	http://purl.obolibrary.org/obo/HP_0012740	Papilloma		Warts, benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas.
http://purl.obolibrary.org/obo/HP_0200044	Porokeratosis	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		A clonal disorder of keratinization with one or multiple atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridgelike border called the cornoid lamella.
http://purl.obolibrary.org/obo/HP_0200046	Cat cry	http://purl.obolibrary.org/obo/HP_0025429	Abnormal cry		The presence of a characteristic high-pitched cry that sounds similar to the meowing of a kitten.
http://purl.obolibrary.org/obo/HP_0200047	Chondritis of pinna	http://purl.obolibrary.org/obo/HP_0100662	Chondritis		Inflammation of the cartilage of the external ear.
http://purl.obolibrary.org/obo/HP_0200049	Upper limb hypertonia	http://purl.obolibrary.org/obo/HP_0002509	Limb hypertonia		Increased muscle tone observed in the arms of the affected person.
http://purl.obolibrary.org/obo/HP_0200053	Hemihypotrophy of lower limb	http://purl.obolibrary.org/obo/HP_0100556	Hemiatrophy		Shortening of a leg affecting only one side.
http://purl.obolibrary.org/obo/HP_0200055	Small hand	http://purl.obolibrary.org/obo/HP_0005927	Aplasia/hypoplasia involving bones of the hand		Disproportionately small hand.
http://purl.obolibrary.org/obo/HP_0200056	Macular scar	http://purl.obolibrary.org/obo/HP_0007401	Macular atrophy		Fibrous connective tissue consequent upon healing of a wound (i.e., a scar) located in the macula.
http://purl.obolibrary.org/obo/HP_0200057	Marcus Gunn pupil	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		An aberrant pupillary response characterized by (i) Constriction of pupils of both eyes when the light stimulus is applied to the normal eye, and (ii) Dilatation of pupils of both eyes when the light stimulus is rapidly transferred from the normal eye (after brief light exposure to the normal eye) to the affected eye.
http://purl.obolibrary.org/obo/HP_0200063	Colorectal polyposis	http://purl.obolibrary.org/obo/HP_0100743	Neoplasm of the rectum		Multiple abnormal growths that arise from the lining of the large intestine (colon or rectum) and protrude into the intestinal lumen.
http://purl.obolibrary.org/obo/HP_0200064	Asymmetry of iris pigmentation	http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation		Asymmetry between the two irides or asymmetry between different parts of one iris.
http://purl.obolibrary.org/obo/HP_0200067	Recurrent spontaneous abortion	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Repeated episodes of abortion (Expulsion of the product of fertilization before completing the term of gestation) without deliberate interference.
http://purl.obolibrary.org/obo/HP_0200070	Peripheral retinal atrophy	http://purl.obolibrary.org/obo/HP_0001105	Retinal atrophy		A nonspecific term denoting wasting, especially as a result of degeneration, of the peripheral retinal pigment epithelium (RPE) and neurosensory retinal cells.
http://purl.obolibrary.org/obo/HP_0200071	Peripheral vitreoretinal degeneration	http://purl.obolibrary.org/obo/HP_0007773	Vitreoretinopathy		A type of vitreoretinal degeneration with manifestations that are concentrated at the periphery of the retina.
http://purl.obolibrary.org/obo/HP_0200072	Episodic quadriplegia	http://purl.obolibrary.org/obo/HP_0002445	Tetraplegia		Intermittent episodes of paralysis of all four limbs.
http://purl.obolibrary.org/obo/HP_0200084	Giant cell hepatitis	http://purl.obolibrary.org/obo/HP_0012115	Hepatitis		Chronic hepatitis characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver.
http://purl.obolibrary.org/obo/HP_0200096	Triangular-shaped open mouth	http://purl.obolibrary.org/obo/HP_0000207	Triangular mouth		A facial appearance characterized by a permanently or nearly permanently opened mouth, in which the upper lip is tented in a way that the opened mouth has the appearance of a triangle.
http://purl.obolibrary.org/obo/HP_0200097	Oral mucosal blisters	http://purl.obolibrary.org/obo/HP_0033800	Blistering by anatomical location		Blisters arising in the mouth.
http://purl.obolibrary.org/obo/HP_0200098	Absent skin pigmentation	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin		Lack of skin pigmentation (coloring).
http://purl.obolibrary.org/obo/HP_0200104	Absent fifth fingernail	http://purl.obolibrary.org/obo/HP_0001817	Absent fingernail		Absence of nail of little finger.
http://purl.obolibrary.org/obo/HP_0200117	Recurrent upper and lower respiratory tract infections	http://purl.obolibrary.org/obo/HP_0002788	Recurrent upper respiratory tract infections		Increased susceptibility to upper and lower respiratory tract infections as manifested by recurrent episodes of upper and lower respiratory tract infections.
http://purl.obolibrary.org/obo/HP_0200119	Acute hepatitis	http://purl.obolibrary.org/obo/HP_0012115	Hepatitis		Acute hepatic injury resulting from inflammation typically accompanied by increased serum alanine transaminase activity. Etiologies include viral hepatitis, drugs, toxins, and autoimmune disorders.
http://purl.obolibrary.org/obo/HP_0200120	Chronic active hepatitis	http://purl.obolibrary.org/obo/HP_0200123	Chronic hepatitis		Chronic hepatitis associated with recurrent clinical exacerbations, extrahepatic manifestations, and progression to cirrhosis.
http://purl.obolibrary.org/obo/HP_0200123	Chronic hepatitis	http://purl.obolibrary.org/obo/HP_0012115	Hepatitis		Hepatitis that lasts for more than six months.
http://purl.obolibrary.org/obo/HP_0200124	Chronic hepatitis due to cryptosporidium infection	http://purl.obolibrary.org/obo/HP_5210119	Unusual Cryptosporidium infection		Chronic hepatitis caused by Cryptosporidium infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_0200127	Atrial cardiomyopathy	http://purl.obolibrary.org/obo/HP_0001638	Cardiomyopathy		Any complex of structural, architectural, contractile or electrophysiological changes affecting the atria with the potential to produce clinically relevant manifestations.
http://purl.obolibrary.org/obo/HP_0200128	Biventricular hypertrophy	http://purl.obolibrary.org/obo/HP_0001714	Ventricular hypertrophy		Thickening of the heart walls in both ventricles.
http://purl.obolibrary.org/obo/HP_0200134	Epileptic encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		A condition in which epileptiform abnormalities are believed to contribute to the progressive disturbance in cerebral function. Epileptic encephalaopathy is characterized by (1) electrographic EEG paroxysmal activity that is often aggressive, (2) seizures that are usually multiform and intractable, (3) cognitive, behavioral and neurological deficits that may be relentless, and (4) sometimes early death.
http://purl.obolibrary.org/obo/HP_0200146	Mucoid extracellular matrix accumulation	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.).
http://purl.obolibrary.org/obo/HP_0200147	Neuronal loss in basal ganglia	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		A reduction in the number of nerve cells in the basal ganglia.
http://purl.obolibrary.org/obo/HP_0200149	CSF lymphocytic pleiocytosis	http://purl.obolibrary.org/obo/HP_0012229	CSF pleocytosis		An increased lymphocyte count in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0200151	Cutaneous mastocytosis	http://purl.obolibrary.org/obo/HP_0100495	Mastocytosis		Multifocal dense infiltrates of mast cells in cutaneous tissue.
http://purl.obolibrary.org/obo/UBERON_0000003	naris	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		Orifice of the olfactory system. The naris is the route by which odorants enter the olfactory system[MAH].
http://purl.obolibrary.org/obo/UBERON_0000006	islet of Langerhans	http://purl.obolibrary.org/obo/UBERON_0034922	cell cluster		The clusters of hormone-producing cells that are scattered throughout the pancreas.
http://purl.obolibrary.org/obo/UBERON_0000009	submucosa	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0000011	parasympathetic nervous system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia[GO].
http://purl.obolibrary.org/obo/UBERON_0000012	somatic nervous system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
http://purl.obolibrary.org/obo/UBERON_0000013	sympathetic nervous system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO].
http://purl.obolibrary.org/obo/UBERON_0000015	non-material anatomical boundary	http://purl.obolibrary.org/obo/UBERON_0000466	immaterial anatomical entity		A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.
http://purl.obolibrary.org/obo/UBERON_0000019	camera-type eye	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid.
http://purl.obolibrary.org/obo/UBERON_0000025	tube	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.
http://purl.obolibrary.org/obo/UBERON_0000026	appendage	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		Major subdivision of an organism that protrudes from the body[DOS, CARO].
http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions.
http://purl.obolibrary.org/obo/UBERON_0000031	lamina propria of trachea	http://purl.obolibrary.org/obo/UBERON_0004779	respiratory system lamina propria		A lamina propria that is part of a respiratory airway.
http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.
http://purl.obolibrary.org/obo/UBERON_0000043	tendon	http://purl.obolibrary.org/obo/UBERON_0007846	dense regular connective tissue		Dense regular connective tissue that connects muscle to bone[VSAO].
http://purl.obolibrary.org/obo/UBERON_0000045	ganglion	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A biological tissue mass, most commonly a mass of nerve cell bodies.
http://purl.obolibrary.org/obo/UBERON_0000047	simple eye	http://purl.obolibrary.org/obo/UBERON_0000970	eye		An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity.
http://purl.obolibrary.org/obo/UBERON_0000053	macula lutea	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		An oval area in the retina, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototopic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed).
http://purl.obolibrary.org/obo/UBERON_0000054	macula	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Thickened areas of the saccule or utricle where the termination of the vestibular nerve occurs[MESH,modified].
http://purl.obolibrary.org/obo/UBERON_0000055	vessel	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A tubular structure that contains, conveys body fluid, such as blood or lymph.
http://purl.obolibrary.org/obo/UBERON_0000058	duct	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		A tubular structure that transports secreted or excreted substances.
http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.
http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure	http://purl.obolibrary.org/obo/UBERON_0000465	material anatomical entity		Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
http://purl.obolibrary.org/obo/UBERON_0000062	organ	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Anatomical structure that performs a specific function or group of functions [WP].
http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.
http://purl.obolibrary.org/obo/UBERON_0000064	organ part	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		A multicellular structure that is a part of an organ.
http://purl.obolibrary.org/obo/UBERON_0000066	fully formed stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.
http://purl.obolibrary.org/obo/UBERON_0000068	embryo stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		A life cycle stage that starts with fertilization and ends with the fully formed embryo.
http://purl.obolibrary.org/obo/UBERON_0000071	death stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		End of the life of an organism.
http://purl.obolibrary.org/obo/UBERON_0000072	proximo-distal subdivision of respiratory tract	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		An section of a respiratory tract.
http://purl.obolibrary.org/obo/UBERON_0000073	regional part of nervous system	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.
http://purl.obolibrary.org/obo/UBERON_0000074	renal glomerulus	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO].
http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.
http://purl.obolibrary.org/obo/UBERON_0000076	external ectoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.
http://purl.obolibrary.org/obo/UBERON_0000077	mixed endoderm/mesoderm-derived structure	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		An anatomical structure that develops from the endoderm and the mesoderm.
http://purl.obolibrary.org/obo/UBERON_0000078	mixed ectoderm/mesoderm/endoderm-derived structure	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		An anatomical structure that develops from the ectoderm, mesoderm and endoderm.
http://purl.obolibrary.org/obo/UBERON_0000080	mesonephros	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo.
http://purl.obolibrary.org/obo/UBERON_0000081	metanephros	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO].
http://purl.obolibrary.org/obo/UBERON_0000083	mesonephric tubule	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP].
http://purl.obolibrary.org/obo/UBERON_0000084	ureteric bud	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP].
http://purl.obolibrary.org/obo/UBERON_0000085	morula	http://purl.obolibrary.org/obo/UBERON_0000922	embryo		A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.
http://purl.obolibrary.org/obo/UBERON_0000086	zona pellucida	http://purl.obolibrary.org/obo/UBERON_0005764	acellular membrane		A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes.
http://purl.obolibrary.org/obo/UBERON_0000087	inner cell mass	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A mass of cells that develop into the body of the embryo and some extraembryonic tissues.
http://purl.obolibrary.org/obo/UBERON_0000088	trophoblast	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta.
http://purl.obolibrary.org/obo/UBERON_0000091	bilaminar disc	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc.
http://purl.obolibrary.org/obo/UBERON_0000092	post-embryonic stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		Stage succeeding embryo, including mature structure.
http://purl.obolibrary.org/obo/UBERON_0000093	sulcus	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A depression or fissure in the surface of an organ.
http://purl.obolibrary.org/obo/UBERON_0000094	membrane organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA].
http://purl.obolibrary.org/obo/UBERON_0000095	cardiac neural crest	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia].
http://purl.obolibrary.org/obo/UBERON_0000101	lobe of lung	http://purl.obolibrary.org/obo/UBERON_0009912	anatomical lobe		A lung lobe is one of the rounded projections that compose the lung[GO].
http://purl.obolibrary.org/obo/UBERON_0000102	lung vasculature	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO].
http://purl.obolibrary.org/obo/UBERON_0000106	zygote stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		A stage at which the organism is a single cell produced by means of sexual reproduction.
http://purl.obolibrary.org/obo/UBERON_0000107	cleavage stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.
http://purl.obolibrary.org/obo/UBERON_0000108	blastula stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
http://purl.obolibrary.org/obo/UBERON_0000109	gastrula stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
http://purl.obolibrary.org/obo/UBERON_0000110	neurula stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		A chordate developmental stage defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
http://purl.obolibrary.org/obo/UBERON_0000111	organogenesis stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.
http://purl.obolibrary.org/obo/UBERON_0000113	post-juvenile adult stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		The stage of being a sexually mature adult animal.
http://purl.obolibrary.org/obo/UBERON_0000114	lung connective tissue	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin.
http://purl.obolibrary.org/obo/UBERON_0000115	lung epithelium	http://purl.obolibrary.org/obo/UBERON_0004815	lower respiratory tract epithelium		The epithelial layer of the lung.
http://purl.obolibrary.org/obo/UBERON_0000117	respiratory tube	http://purl.obolibrary.org/obo/UBERON_0000025	tube		A tube in the respiratory system. Examples: bronchus, bronchiole, trachea.
http://purl.obolibrary.org/obo/UBERON_0000118	lung bud	http://purl.obolibrary.org/obo/UBERON_0005153	epithelial bud		Structure derived from foregut that becomes a lung[GO].
http://purl.obolibrary.org/obo/UBERON_0000119	cell layer	http://purl.obolibrary.org/obo/UBERON_0000957	lamina		Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium.
http://purl.obolibrary.org/obo/UBERON_0000122	neuron projection bundle	http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure		A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.
http://purl.obolibrary.org/obo/UBERON_0000125	neural nucleus	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).
http://purl.obolibrary.org/obo/UBERON_0000126	cranial nerve nucleus	http://purl.obolibrary.org/obo/UBERON_0002308	nucleus of brain		Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves.
http://purl.obolibrary.org/obo/UBERON_0000127	facial nucleus	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		The group of motor neurons residing in the pons that innervate the muscles of facial expression.
http://purl.obolibrary.org/obo/UBERON_0000128	olivary body	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Prominent oval structure in the medulla oblongata, present in pairs, the lower portion of the brainstem. They contain the olivary nuclei.
http://purl.obolibrary.org/obo/UBERON_0000161	orifice	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified].
http://purl.obolibrary.org/obo/UBERON_0000162	cloaca	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures.
http://purl.obolibrary.org/obo/UBERON_0000163	embryonic cloaca	http://purl.obolibrary.org/obo/UBERON_0000162	cloaca		Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP].
http://purl.obolibrary.org/obo/UBERON_0000164	primitive urogenital sinus	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females.
http://purl.obolibrary.org/obo/UBERON_0000166	oral opening	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		The orifice that connects the mouth to the exterior of the body.
http://purl.obolibrary.org/obo/UBERON_0000168	proximal-distal subdivision of colon	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		A section dividing a colon along a proximal-distal axis.
http://purl.obolibrary.org/obo/UBERON_0000170	pair of lungs	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		The pair of anatomical structures comprised of a left lung and right lung.
http://purl.obolibrary.org/obo/UBERON_0000171	respiration organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
http://purl.obolibrary.org/obo/UBERON_0000173	amniotic fluid	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid.
http://purl.obolibrary.org/obo/UBERON_0000174	excreta	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.
http://purl.obolibrary.org/obo/UBERON_0000179	haemolymphatic fluid	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.
http://purl.obolibrary.org/obo/UBERON_0000199	neck of radius	http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element		The narrow part of the shaft of the radius just below the head.
http://purl.obolibrary.org/obo/UBERON_0000200	gyrus	http://purl.obolibrary.org/obo/UBERON_0034768	morphological feature		A ridge on the cerebral cortex. It is generally surrounded by one or more sulci .
http://purl.obolibrary.org/obo/UBERON_0000203	pallium	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Dorsal part (roof region) of the telencephalon[GO].
http://purl.obolibrary.org/obo/UBERON_0000204	ventral part of telencephalon	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Ventral part (base region) of the telencephalon.
http://purl.obolibrary.org/obo/UBERON_0000209	tetrapod frontal bone	http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone		The bone forming the forehead and roof of the eye orbit.
http://purl.obolibrary.org/obo/UBERON_0000210	tetrapod parietal bone	http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone		In humans: bone forming side and roof of cranium. Each bone is irregularly quadrilateral in form, and has two surfaces, four borders, and four angles.
http://purl.obolibrary.org/obo/UBERON_0000211	ligament	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ.
http://purl.obolibrary.org/obo/UBERON_0000218	vertebral arch of axis	http://purl.obolibrary.org/obo/UBERON_0003861	neural arch		A neural arch that is part of a vertebral bone 2.
http://purl.obolibrary.org/obo/UBERON_0000220	atlanto-occipital joint	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital.
http://purl.obolibrary.org/obo/UBERON_0000303	adductor longus	http://purl.obolibrary.org/obo/UBERON_0011144	adductor muscle of hip		An adductor muscle that attaches to the hip and femur. In humans, it is a part of the adductor group of the thigh, that as the name suggests adducts the thigh. The adductor longus muscle forms the medial wall of the femoral triangle[WP, generalized].
http://purl.obolibrary.org/obo/UBERON_0000305	amnion	http://purl.obolibrary.org/obo/UBERON_0005631	extraembryonic membrane		The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected.
http://purl.obolibrary.org/obo/UBERON_0000307	blastula	http://purl.obolibrary.org/obo/UBERON_0000922	embryo		Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.
http://purl.obolibrary.org/obo/UBERON_0000309	body wall	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		The external portion of an animal body derived from ectoderm and mesoderm layers that encloses the body cavity.
http://purl.obolibrary.org/obo/UBERON_0000311	extensor muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		A skeletal muscle whose contraction extends or stretches a body part.
http://purl.obolibrary.org/obo/UBERON_0000313	portion of cartilage tissue in tibia	http://purl.obolibrary.org/obo/UBERON_0007391	pelvic appendage cartilage tissue		Cartilage pertaining to the tibia.
http://purl.obolibrary.org/obo/UBERON_0000315	subarachnoid space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The space between the arachnoid and pia mater.
http://purl.obolibrary.org/obo/UBERON_0000316	cervical mucus	http://purl.obolibrary.org/obo/UBERON_0000912	mucus		A substance produced by the cervix and endocervical glands[BTO]. Thick acidic mucus that blocks the cervical os after mestruation[WP]. This 'infertile' mucus blocks spermatozoa from entering the uterus.
http://purl.obolibrary.org/obo/UBERON_0000317	colonic mucosa	http://purl.obolibrary.org/obo/UBERON_0001207	mucosa of large intestine		Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells.
http://purl.obolibrary.org/obo/UBERON_0000320	duodenal mucosa	http://purl.obolibrary.org/obo/UBERON_0001204	mucosa of small intestine		A mucosa that is part of a duodenum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000323	late embryo	http://purl.obolibrary.org/obo/UBERON_0000922	embryo		An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching.
http://purl.obolibrary.org/obo/UBERON_0000325	gastric gland	http://purl.obolibrary.org/obo/UBERON_0003294	gland of foregut		The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin.
http://purl.obolibrary.org/obo/UBERON_0000326	pancreatic juice	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.
http://purl.obolibrary.org/obo/UBERON_0000328	gut wall	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity).
http://purl.obolibrary.org/obo/UBERON_0000331	ileal mucosa	http://purl.obolibrary.org/obo/UBERON_0001204	mucosa of small intestine		A mucosa that is part of a ileum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000332	yellow bone marrow	http://purl.obolibrary.org/obo/UBERON_0002371	bone marrow		Bone marrow in which the fat cells predominate in the meshes of the reticular network.
http://purl.obolibrary.org/obo/UBERON_0000333	intestinal gland	http://purl.obolibrary.org/obo/UBERON_0003408	gland of digestive tract		A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm].
http://purl.obolibrary.org/obo/UBERON_0000344	mucosa	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP].
http://purl.obolibrary.org/obo/UBERON_0000345	myelin	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A dielectric (electrically insulating) material consisting of protein and fat that forms a layer, the myelin sheath, usually around only the axon of a neuron. Myelin is about 40 % water; the dry mass of myelin is about 70 - 85 % lipids and about 15 - 30 % proteins. Some of the proteins that make up myelin are myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). The primary lipid of myelin is a glycolipid called galactocerebroside (GalC). The intertwining hydrocarbon chains of sphingomyelin serve to strengthen the myelin sheath.
http://purl.obolibrary.org/obo/UBERON_0000347	entire myelin sheath	http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure		The insulating envelope that surrounds nerve fibers or axons.
http://purl.obolibrary.org/obo/UBERON_0000348	ophthalmic nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead.
http://purl.obolibrary.org/obo/UBERON_0000349	limbic system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		A set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex].
http://purl.obolibrary.org/obo/UBERON_0000351	nuchal ligament	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		A fibrous membrane, which, in the neck, represents the supraspinal ligaments of the upper vertebrae.
http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues.
http://purl.obolibrary.org/obo/UBERON_0000355	pharyngeal mucosa	http://purl.obolibrary.org/obo/UBERON_0004785	respiratory system mucosa		A mucosa that is part of a pharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000358	blastocyst	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO].
http://purl.obolibrary.org/obo/UBERON_0000361	red bone marrow	http://purl.obolibrary.org/obo/UBERON_0002371	bone marrow		The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream.
http://purl.obolibrary.org/obo/UBERON_0000362	renal medulla	http://purl.obolibrary.org/obo/UBERON_0000958	medulla of organ		The inner portion of the kidney consisting of the renal pyramids.
http://purl.obolibrary.org/obo/UBERON_0000366	flexor muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		A skeletal muscle whose contraction bends a joint.
http://purl.obolibrary.org/obo/UBERON_0000369	corpus striatum	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP].
http://purl.obolibrary.org/obo/UBERON_0000371	syncytiotrophoblast	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated).
http://purl.obolibrary.org/obo/UBERON_0000375	mandibular nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini.
http://purl.obolibrary.org/obo/UBERON_0000376	hindlimb stylopod	http://purl.obolibrary.org/obo/UBERON_0008784	lower limb segment		The part of the hindlimb between pelvis and the knee, corresponding to the femur.
http://purl.obolibrary.org/obo/UBERON_0000377	maxillary nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses.
http://purl.obolibrary.org/obo/UBERON_0000378	tongue muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		The muscular portion of the tongue.
http://purl.obolibrary.org/obo/UBERON_0000379	tracheal mucosa	http://purl.obolibrary.org/obo/UBERON_0004785	respiratory system mucosa		A mucosa that is part of a trachea.
http://purl.obolibrary.org/obo/UBERON_0000383	musculature of body	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified].
http://purl.obolibrary.org/obo/UBERON_0000389	lens cortex	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Tissue that surrounds the lens nucleus.
http://purl.obolibrary.org/obo/UBERON_0000390	lens nucleus	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		The core of the crystalline lens, surrounded by the cortex.
http://purl.obolibrary.org/obo/UBERON_0000395	cochlear ganglion	http://purl.obolibrary.org/obo/UBERON_0001714	cranial ganglion		The group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]. distributed to the hair cells of the spiral organ. The cochlear fibers arise in bipolar cells in the spiral ganglion in the modiolus.
http://purl.obolibrary.org/obo/UBERON_0000397	colonic epithelium	http://purl.obolibrary.org/obo/UBERON_0001278	epithelium of large intestine		An epithelium that is part of a colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000398	cartilage tissue of sternum	http://purl.obolibrary.org/obo/UBERON_0003837	thoracic segment connective tissue		Any portion of cartilage tissue that is part of the sternum.
http://purl.obolibrary.org/obo/UBERON_0000399	jejunal mucosa	http://purl.obolibrary.org/obo/UBERON_0001204	mucosa of small intestine		A mucosa that is part of a jejunum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000400	jejunal epithelium	http://purl.obolibrary.org/obo/UBERON_0013636	epithelium of intestinal villus		An epithelium that is part of a jejunum.
http://purl.obolibrary.org/obo/UBERON_0000401	mandibular ramus	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The upturned perpendicular extremity of the mandible.
http://purl.obolibrary.org/obo/UBERON_0000409	serous gland	http://purl.obolibrary.org/obo/UBERON_0002365	exocrine gland		A gland in which the principal secretory cells are serous secreting cells.
http://purl.obolibrary.org/obo/UBERON_0000410	bronchial mucosa	http://purl.obolibrary.org/obo/UBERON_0004785	respiratory system mucosa		A mucosa that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000414	mucous gland	http://purl.obolibrary.org/obo/UBERON_0002365	exocrine gland		A gland in which the principal secretory cells are mucus secreting cells.
http://purl.obolibrary.org/obo/UBERON_0000415	artery wall	http://purl.obolibrary.org/obo/UBERON_0035965	wall of blood vessel		An anatomical wall that is part of an artery [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000428	prostate epithelium	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		The prostate epithelium.
http://purl.obolibrary.org/obo/UBERON_0000429	enteric plexus	http://purl.obolibrary.org/obo/UBERON_0001816	autonomic nerve plexus		A plexus of autonomic nerve fibers within the wall of the digestive tube, and made up of the submucosal, myenteric, and subserosal plexuses; it contains visceral afferent fibers, sympathetic postganglionic fibers, parasympathetic preganglionic and postganglionic fibers, and parasympathetic postganglionic cell bodies.
http://purl.obolibrary.org/obo/UBERON_0000439	arachnoid trabecula	http://purl.obolibrary.org/obo/UBERON_0000440	trabecula		The arachnoid trabeculae are delicate strands of connective tissue that loosely connect the two innermost layers of the meninges -- the arachnoid mater and the pia mater. They are found within the subarachnoid space where cerebrospinal fluid is also found. Embryologically, the trabeculae are the remnants of the common precursor that forms both the arachnoid and pial layers of the meninges.
http://purl.obolibrary.org/obo/UBERON_0000440	trabecula	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP].
http://purl.obolibrary.org/obo/UBERON_0000442	right testicular vein	http://purl.obolibrary.org/obo/UBERON_0001144	testicular vein		A vein that drains the left pampiniform plexus and empties into the left renal vein.
http://purl.obolibrary.org/obo/UBERON_0000443	left testicular vein	http://purl.obolibrary.org/obo/UBERON_0001144	testicular vein		A vein that drains the right pampiniform plexus and empties into the inferior vena cava.
http://purl.obolibrary.org/obo/UBERON_0000446	septum of telencephalon	http://purl.obolibrary.org/obo/UBERON_0005401	cerebral hemisphere gray matter		Gray matter structure located on the midline of the forebrain consisting of the septum pellucidum (in some species) and the septal nuclei (Heimer, 1996).
http://purl.obolibrary.org/obo/UBERON_0000454	cerebral subcortex	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain.
http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		A portion of organism substance that is produced by exocrine glands.
http://purl.obolibrary.org/obo/UBERON_0000457	cavernous artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		Any of several small branches of the internal carotid artery that supply the trigeminal ganglion and the walls of the cavernous and petrosal sinuses.
http://purl.obolibrary.org/obo/UBERON_0000459	uterine wall	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An anatomical wall that is part of a uterus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0000463	organism substance	http://purl.obolibrary.org/obo/UBERON_0000001	gross anatomical part		Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space	http://purl.obolibrary.org/obo/UBERON_0000466	immaterial anatomical entity		Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.
http://purl.obolibrary.org/obo/UBERON_0000465	material anatomical entity	http://purl.obolibrary.org/obo/UBERON_0001062	anatomical entity		Anatomical entity that has mass.
http://purl.obolibrary.org/obo/UBERON_0000466	immaterial anatomical entity	http://purl.obolibrary.org/obo/UBERON_0001062	anatomical entity		Anatomical entity that has no mass.
http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Anatomical structure that is an individual member of a species and consists of more than one cell.
http://purl.obolibrary.org/obo/UBERON_0000471	compound organ component	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		Multi-tissue structure that is part of a compound organ.
http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.
http://purl.obolibrary.org/obo/UBERON_0000476	acellular anatomical structure	http://purl.obolibrary.org/obo/UBERON_0000001	gross anatomical part		Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.
http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster	http://purl.obolibrary.org/obo/UBERON_0034923	disconnected anatomical group		Anatomical group whose component anatomical structures lie in close proximity to each other.
http://purl.obolibrary.org/obo/UBERON_0000478	extraembryonic structure	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis.
http://purl.obolibrary.org/obo/UBERON_0000479	tissue	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.
http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.
http://purl.obolibrary.org/obo/UBERON_0000482	basal lamina of epithelium	http://purl.obolibrary.org/obo/UBERON_0005764	acellular membrane		Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue.
http://purl.obolibrary.org/obo/UBERON_0000483	epithelium	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].
http://purl.obolibrary.org/obo/UBERON_0000484	simple cuboidal epithelium	http://purl.obolibrary.org/obo/UBERON_0010077	cuboidal epithelium		Unilaminar epithelium that consists of a single layer of cuboidal cells.
http://purl.obolibrary.org/obo/UBERON_0000485	simple columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0012274	columnar epithelium		Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA].
http://purl.obolibrary.org/obo/UBERON_0000486	multilaminar epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA].
http://purl.obolibrary.org/obo/UBERON_0000487	simple squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006914	squamous epithelium		Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].
http://purl.obolibrary.org/obo/UBERON_0000488	atypical epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelium that consists of epithelial cells not arranged in one ore more layers.
http://purl.obolibrary.org/obo/UBERON_0000489	cavitated compound organ	http://purl.obolibrary.org/obo/UBERON_0003103	compound organ		Compound organ that contains one or more macroscopic anatomical spaces.
http://purl.obolibrary.org/obo/UBERON_0000490	unilaminar epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].
http://purl.obolibrary.org/obo/UBERON_0000642	suspensory ligament of duodenum	http://purl.obolibrary.org/obo/UBERON_0008841	suspensory ligament		A thin muscle connecting the junction between the duodenum, jejunum, and duodenojejunal flexure to connective tissue surrounding the superior mesenteric artery and coeliac artery.
http://purl.obolibrary.org/obo/UBERON_0000912	mucus	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water.
http://purl.obolibrary.org/obo/UBERON_0000913	interstitial fluid	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		Interstitial fluid is a bodily fluid consisting of a solution which bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid.
http://purl.obolibrary.org/obo/UBERON_0000916	abdomen	http://purl.obolibrary.org/obo/UBERON_0009569	subdivision of trunk		The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0000922	embryo	http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism		Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
http://purl.obolibrary.org/obo/UBERON_0000923	germ layer	http://purl.obolibrary.org/obo/UBERON_0010316	germ layer / neural crest		A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.
http://purl.obolibrary.org/obo/UBERON_0000924	ectoderm	http://purl.obolibrary.org/obo/UBERON_0000923	germ layer		Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
http://purl.obolibrary.org/obo/UBERON_0000925	endoderm	http://purl.obolibrary.org/obo/UBERON_0000923	germ layer		Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
http://purl.obolibrary.org/obo/UBERON_0000926	mesoderm	http://purl.obolibrary.org/obo/UBERON_0000923	germ layer		The middle germ layer of the embryo, between the endoderm and ectoderm.
http://purl.obolibrary.org/obo/UBERON_0000929	pharyngeal branch of vagus nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		Motor nerve of the pharynx, arises from the upper part of the ganglion nodosum, and consists principally of filaments from the cranial portion of the accessory nerve.
http://purl.obolibrary.org/obo/UBERON_0000930	stomodeum	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity.
http://purl.obolibrary.org/obo/UBERON_0000931	proctodeum	http://purl.obolibrary.org/obo/UBERON_0016566	pit		Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0000933	chordate pharyngeal muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		A muscle that acts on the pharynx[WP, vetted].
http://purl.obolibrary.org/obo/UBERON_0000935	anterior commissure	http://purl.obolibrary.org/obo/UBERON_0005341	ventral commissure		A bundle of myelinated nerve fibers passing transversely through the lamina terminalis and connecting symmetrical parts of the two cerebral hemispheres; it consists of a smaller anterior part (pars anterior commissurae anterioris) and a larger posterior part (pars posterior commissurae anterioris).
http://purl.obolibrary.org/obo/UBERON_0000941	cranial nerve II	http://purl.obolibrary.org/obo/UBERON_0034713	cranial neuron projection bundle		Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA].
http://purl.obolibrary.org/obo/UBERON_0000951	rotator muscle of the vertebral column	http://purl.obolibrary.org/obo/UBERON_0005174	dorsal region element		Any of a number of short transversospinal muscles chiefly developed in cervical, lumbar, and thoracic regions, arising from the transverse process of one vertebra and inserted into the root of the spinous process of the next two or three vertebrae above, with nerve supply from the dorsal branches of the spinal nerve, and whose actions rotate the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0000956	cerebral cortex	http://purl.obolibrary.org/obo/UBERON_0016548	central nervous system gray matter layer		The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.
http://purl.obolibrary.org/obo/UBERON_0000957	lamina	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Any thin layer or plate.
http://purl.obolibrary.org/obo/UBERON_0000958	medulla of organ	http://purl.obolibrary.org/obo/UBERON_0000471	compound organ component		Middle part of an organ, surrounded by the cortex.
http://purl.obolibrary.org/obo/UBERON_0000962	nerve of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0001780	spinal nerve		The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0000976	humerus	http://purl.obolibrary.org/obo/UBERON_0015053	humerus endochondral element		Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah].
http://purl.obolibrary.org/obo/UBERON_0000978	leg	http://purl.obolibrary.org/obo/UBERON_0008784	lower limb segment		The portion of the hindlimb that contains both the stylopod and zeugopod.
http://purl.obolibrary.org/obo/UBERON_0000979	tibia	http://purl.obolibrary.org/obo/UBERON_0015004	tibia endochondral element		The major preaxial endochondral bone in the posterior zeugopod[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0000980	trochanter	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		A bony prominence near the extremity of the femur that normally serves as attachment points for hip and thigh muscles[MP,modified].
http://purl.obolibrary.org/obo/UBERON_0000981	femur	http://purl.obolibrary.org/obo/UBERON_0015052	femur endochondral element		Endochondral longbone connecting the pelvic girdle with posterior zeugopodium skeleton.[VSAO, modified].
http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint	http://purl.obolibrary.org/obo/UBERON_0004905	articulation		Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].
http://purl.obolibrary.org/obo/UBERON_0000983	metatarsus region	http://purl.obolibrary.org/obo/UBERON_0009877	metapodium region		A metapodium region that is part of a pes.
http://purl.obolibrary.org/obo/UBERON_0000985	axillary vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		Vein that drains the axilla.
http://purl.obolibrary.org/obo/UBERON_0000988	pons	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum.
http://purl.obolibrary.org/obo/UBERON_0000993	oviduct	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A tube or collection of tubes in an animal from the ovaries to the outside of the body.
http://purl.obolibrary.org/obo/UBERON_0000999	ejaculatory duct	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The Ejaculatory ducts (ductus ejaculatorii) are paired structures in male anatomy, about 2 cm in length. Each ejaculatory duct is formed by the union of the vas deferens with the duct of the seminal vesicle. They pass through the prostate, and empty into the urethra at the Colliculus seminalis. During ejaculation, semen passes through the ducts and exits the body via the penis[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001000	vas deferens	http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system		A secretory duct that transports sperm from the testis. In mammals this is a continuation of the epididymis and ends in the prostatic urethra where it terminates to form ejaculatory duct.
http://purl.obolibrary.org/obo/UBERON_0001005	respiratory airway	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		An airway through which respiratory air passes in organisms.
http://purl.obolibrary.org/obo/UBERON_0001009	circulatory system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].
http://purl.obolibrary.org/obo/UBERON_0001010	diaphysis of ulna	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		The body of the ulna at its upper part is prismatic in form, and curved so as to be convex behind and lateralward; its central part is straight; its lower part is rounded, smooth, and bent a little lateralward. It tapers gradually from above downward, and has three borders and three surfaces.
http://purl.obolibrary.org/obo/UBERON_0001012	head of radius	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		The head of the radius has a cylindrical form, and on its upper surface is a shallow cup or fovea for articulation with the capitulum (or capitellum) of the humerus. The circumference of the head is smooth; it is broad medially where it articulates with the radial notch of the ulna, narrow in the rest of its extent, which is embraced by the annular ligament. The deepest point in the fovea is not axi-symmetric with the long axis of the radius, creating a cam effect during pronation and supination[WP].
http://purl.obolibrary.org/obo/UBERON_0001013	adipose tissue	http://purl.obolibrary.org/obo/UBERON_0011822	dense irregular connective tissue		Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.
http://purl.obolibrary.org/obo/UBERON_0001015	musculature	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		A subdivision of the muscular system corresponding to a subdisivision of an organism.
http://purl.obolibrary.org/obo/UBERON_0001018	axon tract	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		A group of axons linking two or more neuropils and having a common origin, termination[FBbt].
http://purl.obolibrary.org/obo/UBERON_0001019	nerve fasciculus	http://purl.obolibrary.org/obo/UBERON_0000122	neuron projection bundle		A slender neuron projection bundle[FBbt]; A bundle of anatomical fibers, as of muscle or nerve (American Heritage Dictionary 4th ed).
http://purl.obolibrary.org/obo/UBERON_0001020	nervous system commissure	http://purl.obolibrary.org/obo/UBERON_0001018	axon tract		Axon tract that crosses the midline of the central nervous system[NIF, modified]. In the context of Drosophila refers to a broad band of axons connecting equivalent neuropils each side of the brain[FBbt].
http://purl.obolibrary.org/obo/UBERON_0001021	nerve	http://purl.obolibrary.org/obo/UBERON_0000122	neuron projection bundle		An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.
http://purl.obolibrary.org/obo/UBERON_0001027	sensory nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that transmits from sensory receptors on the surface of the body to the central nervous system.
http://purl.obolibrary.org/obo/UBERON_0001028	diaphysis of radius	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		A diaphysis that is part of a radius bone[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001033	gustatory system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		The sensory system for the sense of taste.
http://purl.obolibrary.org/obo/UBERON_0001040	yolk sac	http://purl.obolibrary.org/obo/UBERON_0007499	epithelial sac		A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP].
http://purl.obolibrary.org/obo/UBERON_0001041	foregut	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		Anterior subdivision of a digestive tract.
http://purl.obolibrary.org/obo/UBERON_0001042	chordate pharynx	http://purl.obolibrary.org/obo/UBERON_0006562	pharynx		A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED].
http://purl.obolibrary.org/obo/UBERON_0001045	midgut	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO].
http://purl.obolibrary.org/obo/UBERON_0001046	hindgut	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The caudalmost subdivision of a digestive tract.
http://purl.obolibrary.org/obo/UBERON_0001048	primordium	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)].
http://purl.obolibrary.org/obo/UBERON_0001049	neural tube	http://purl.obolibrary.org/obo/UBERON_0016879	future central nervous system		In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001051	hypopharynx	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		Bottom part of the pharynx that connects to the esophagus.
http://purl.obolibrary.org/obo/UBERON_0001064	ventral pancreatic duct	http://purl.obolibrary.org/obo/UBERON_0000025	tube		A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla.
http://purl.obolibrary.org/obo/UBERON_0001066	intervertebral disk	http://purl.obolibrary.org/obo/UBERON_0011135	intervertebral cartilage		A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core.
http://purl.obolibrary.org/obo/UBERON_0001067	vertebral arch joint	http://purl.obolibrary.org/obo/UBERON_0002217	synovial joint		A synovial joint between the prezygapophysis of one vertebra and the postzygapophysis of the vertebra directly above it. There are two facet joints in each spinal motion segment[WP].
http://purl.obolibrary.org/obo/UBERON_0001068	skin of back	http://purl.obolibrary.org/obo/UBERON_0001085	skin of trunk		A zone of skin that is part of a back [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001070	external carotid artery	http://purl.obolibrary.org/obo/UBERON_0005396	carotid artery segment		A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP].
http://purl.obolibrary.org/obo/UBERON_0001071	superficial cervical artery	http://purl.obolibrary.org/obo/UBERON_0012320	cervical artery		It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery.
http://purl.obolibrary.org/obo/UBERON_0001072	inferior vena cava	http://purl.obolibrary.org/obo/UBERON_0004087	vena cava		A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart.
http://purl.obolibrary.org/obo/UBERON_0001073	ileocecal junction	http://purl.obolibrary.org/obo/UBERON_8410024	intestinal junction		A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice.
http://purl.obolibrary.org/obo/UBERON_0001074	pericardial cavity	http://purl.obolibrary.org/obo/UBERON_0035809	serous cavity		A potential space between the visceral and parietal layers of the pericardium.
http://purl.obolibrary.org/obo/UBERON_0001075	bony vertebral centrum	http://purl.obolibrary.org/obo/UBERON_0016491	vertebral centrum element		Ossified form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified].
http://purl.obolibrary.org/obo/UBERON_0001076	neural spine	http://purl.obolibrary.org/obo/UBERON_0006061	process of vertebra		An extension of a neural arches dorsal to the neural canal[TAO,modified].
http://purl.obolibrary.org/obo/UBERON_0001077	transverse process of vertebra	http://purl.obolibrary.org/obo/UBERON_0006061	process of vertebra		The transverse or costal processes of a vertebra, two in number, project one at either side from the point where the lamina joins the pedicle, between the superior and inferior articular processes. They serve for the attachment of muscles and ligaments. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001078	pedicle of vertebra	http://purl.obolibrary.org/obo/UBERON_0006061	process of vertebra		The two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae.
http://purl.obolibrary.org/obo/UBERON_0001079	prezygapophysis	http://purl.obolibrary.org/obo/UBERON_0006062	zygapophysis		Paired processes at the cephalic end of the neural arch. The articular facets of the prezygapophyses face dorsomedially and articulate with the lateroventrally facing facets of the postzygapophyses of the preceding vertebra.
http://purl.obolibrary.org/obo/UBERON_0001080	postzygapophysis	http://purl.obolibrary.org/obo/UBERON_0006062	zygapophysis		Paired processes at the caudal end of the neural arch. The articular facets of the postzygapophyses face lateroventrally and articulate with the dorsomedially facing facets of the prezygapophyses of the succeeding vertebra.
http://purl.obolibrary.org/obo/UBERON_0001081	endocardium of ventricle	http://purl.obolibrary.org/obo/UBERON_0002165	endocardium		Endocardium that is part of the cardiac ventricle.
http://purl.obolibrary.org/obo/UBERON_0001082	epicardium of ventricle	http://purl.obolibrary.org/obo/UBERON_0002348	epicardium		An epicardial layer that lines a cardiac ventricle.
http://purl.obolibrary.org/obo/UBERON_0001083	myocardium of ventricle	http://purl.obolibrary.org/obo/UBERON_0002349	myocardium		Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer.
http://purl.obolibrary.org/obo/UBERON_0001084	skin of head	http://purl.obolibrary.org/obo/UBERON_0012180	head or neck skin		A zone of skin that is part of a head [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001085	skin of trunk	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is part of a trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001087	pleural fluid	http://purl.obolibrary.org/obo/UBERON_0036244	secretion of serous membrane		Transudate contained in the pleural cavity.
http://purl.obolibrary.org/obo/UBERON_0001088	urine	http://purl.obolibrary.org/obo/UBERON_0000174	excreta		Excretion that is the output of a kidney.
http://purl.obolibrary.org/obo/UBERON_0001089	sweat	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Secretion produced by a sweat gland.
http://purl.obolibrary.org/obo/UBERON_0001090	synovial fluid	http://purl.obolibrary.org/obo/UBERON_0007794	secretion of serous gland		Joint fluid is a transudate of plasma that is actively secreted by synovial cells.
http://purl.obolibrary.org/obo/UBERON_0001092	vertebral bone 1	http://purl.obolibrary.org/obo/UBERON_0002412	vertebra		The first vertebral bone in the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0001093	vertebral bone 2	http://purl.obolibrary.org/obo/UBERON_0002412	vertebra		The second vertebral bone in the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0001094	sacral vertebra	http://purl.obolibrary.org/obo/UBERON_0015010	sacral vertebra endochondral element		A vertebra bone that is part of the sacral region of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0001095	caudal vertebra	http://purl.obolibrary.org/obo/UBERON_0018142	caudal vertebra endochondral element		Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx).
http://purl.obolibrary.org/obo/UBERON_0001096	wall of esophagus	http://purl.obolibrary.org/obo/UBERON_0000328	gut wall		An anatomical wall that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001098	incisor tooth	http://purl.obolibrary.org/obo/UBERON_0001091	calcareous tooth		Incisors are the first kind of tooth in heterodont mammals. They are located in the premaxilla above and mandible below. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001100	pectoralis minor	http://purl.obolibrary.org/obo/UBERON_0001495	pectoral muscle		The Pectoralis minor is a thin, triangular muscle, situated at the upper part of the chest, beneath the Pectoralis major. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001105	clavicle bone	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A paired dermal or endochondral bone that is part of the pectoral girdle. The clavicle may be in contact with the interclavicle or coracoid and forms an attachment site for pectoral musculature. [PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0001111	intercostal muscle	http://purl.obolibrary.org/obo/UBERON_8450004	intercostal element		The respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib.
http://purl.obolibrary.org/obo/UBERON_0001112	latissimus dorsi muscle	http://purl.obolibrary.org/obo/UBERON_0034908	scapular muscle		The latissimus dorsi is the larger, flat, dorso-lateral muscle on the trunk, posterior to the arm, and partly covered by the trapezius on its median dorsal region. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001113	lobe of liver	http://purl.obolibrary.org/obo/UBERON_0009912	anatomical lobe		Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe.
http://purl.obolibrary.org/obo/UBERON_0001114	right lobe of liver	http://purl.obolibrary.org/obo/UBERON_0001113	lobe of liver		The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001115	left lobe of liver	http://purl.obolibrary.org/obo/UBERON_0001113	lobe of liver		The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001118	lobe of thyroid gland	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A lobe of tissue that is part of a thyroid gland.
http://purl.obolibrary.org/obo/UBERON_0001119	right lobe of thyroid gland	http://purl.obolibrary.org/obo/UBERON_0001118	lobe of thyroid gland		A lobe of thyroid gland that is in the right side of a thyroid gland.
http://purl.obolibrary.org/obo/UBERON_0001120	left lobe of thyroid gland	http://purl.obolibrary.org/obo/UBERON_0001118	lobe of thyroid gland		A lobe of thyroid gland that is in the left side of a thyroid gland.
http://purl.obolibrary.org/obo/UBERON_0001125	serratus ventralis	http://purl.obolibrary.org/obo/UBERON_0034908	scapular muscle		The serratus ventralis is a muscle that originates on the surface of the upper eight or nine ribs at the side of the chest and inserts along the entire anterior length of the medial border of the scapula. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001131	vertebral foramen	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch.
http://purl.obolibrary.org/obo/UBERON_0001133	cardiac muscle tissue	http://purl.obolibrary.org/obo/UBERON_8600006	visceral striated muscle tissue		Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified].
http://purl.obolibrary.org/obo/UBERON_0001136	mesothelium	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).
http://purl.obolibrary.org/obo/UBERON_0001137	dorsum	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column..
http://purl.obolibrary.org/obo/UBERON_0001138	superior mesenteric vein	http://purl.obolibrary.org/obo/UBERON_0005617	mesenteric vein		In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001139	common iliac vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A vein that drains the pelvis and lower limbs into the inferior vena cava.
http://purl.obolibrary.org/obo/UBERON_0001140	renal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava.
http://purl.obolibrary.org/obo/UBERON_0001141	right renal vein	http://purl.obolibrary.org/obo/UBERON_0001140	renal vein		A renal vein that drains the right kidney.
http://purl.obolibrary.org/obo/UBERON_0001142	left renal vein	http://purl.obolibrary.org/obo/UBERON_0001140	renal vein		A renal vein that drains the left kidney.
http://purl.obolibrary.org/obo/UBERON_0001143	hepatic vein	http://purl.obolibrary.org/obo/UBERON_0015796	liver blood vessel		Vein that carries blood away from the liver[ZFA].
http://purl.obolibrary.org/obo/UBERON_0001144	testicular vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A vein that carries deoxygenated blood from a single male gonad. It is the male equivalent of the ovarian vein, and is the venous counterpart of the testicular artery. It is a paired vein, with one supplying each testis.
http://purl.obolibrary.org/obo/UBERON_0001145	ovarian vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries.
http://purl.obolibrary.org/obo/UBERON_0001146	suprarenal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains the adrenal gland.
http://purl.obolibrary.org/obo/UBERON_0001148	median nerve	http://purl.obolibrary.org/obo/UBERON_0003433	arm nerve		A nerve of the arm that originates from the brachial plexus and is formed from parts of the medial and lateral cords of the brachial plexus, and continues down the arm to enter the forearm with the brachial artery. It originates from the brachial plexus with roots from C5, C6, C7, C8 &amp; T1.
http://purl.obolibrary.org/obo/UBERON_0001152	cystic duct	http://purl.obolibrary.org/obo/UBERON_0003703	extrahepatic bile duct		The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct.
http://purl.obolibrary.org/obo/UBERON_0001167	wall of stomach	http://purl.obolibrary.org/obo/UBERON_0000328	gut wall		The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between.
http://purl.obolibrary.org/obo/UBERON_0001168	wall of small intestine	http://purl.obolibrary.org/obo/UBERON_0001262	wall of intestine		An anatomical wall that is part of a small intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001169	wall of large intestine	http://purl.obolibrary.org/obo/UBERON_0001262	wall of intestine		An anatomical wall that is part of a large intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001170	mesentery of small intestine	http://purl.obolibrary.org/obo/UBERON_0007826	peritoneal mesentery		The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP].
http://purl.obolibrary.org/obo/UBERON_0001171	portal lobule	http://purl.obolibrary.org/obo/UBERON_0009911	lobule		The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.
http://purl.obolibrary.org/obo/UBERON_0001172	hepatic acinus	http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland		The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids.
http://purl.obolibrary.org/obo/UBERON_0001175	common hepatic duct	http://purl.obolibrary.org/obo/UBERON_0003703	extrahepatic bile duct		Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP].
http://purl.obolibrary.org/obo/UBERON_0001176	right hepatic duct	http://purl.obolibrary.org/obo/UBERON_0003703	extrahepatic bile duct		The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct.
http://purl.obolibrary.org/obo/UBERON_0001177	left hepatic duct	http://purl.obolibrary.org/obo/UBERON_0003703	extrahepatic bile duct		The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct.
http://purl.obolibrary.org/obo/UBERON_0001178	visceral peritoneum	http://purl.obolibrary.org/obo/UBERON_0022350	visceral serous membrane		The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space.
http://purl.obolibrary.org/obo/UBERON_0001179	peritoneal cavity	http://purl.obolibrary.org/obo/UBERON_0035809	serous cavity		Anatomical cavity bounded by visceral and parietal peritoneum.
http://purl.obolibrary.org/obo/UBERON_0001183	inferior mesenteric artery	http://purl.obolibrary.org/obo/UBERON_0035039	rectal artery		Mesenteric artery that supplies the large intestine from the left colic (or splenic) flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum. Proximally, its territory of distribution overlaps (forms a watershed) with the middle colic artery, and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery (artery of Drummond). The territory of distribution of the IMA is more or less equivalent to the embryonic hindgut. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001185	right renal artery	http://purl.obolibrary.org/obo/UBERON_0001184	renal artery		Renal artery that supplies the right kidney.
http://purl.obolibrary.org/obo/UBERON_0001186	left renal artery	http://purl.obolibrary.org/obo/UBERON_0001184	renal artery		Renal artery that supplies the left kidney.
http://purl.obolibrary.org/obo/UBERON_0001187	testicular artery	http://purl.obolibrary.org/obo/UBERON_0010192	genital artery		One of a pair of arteries that is a branch of the abdominal aorta that supplies blood to a male gonad.
http://purl.obolibrary.org/obo/UBERON_0001188	right testicular artery	http://purl.obolibrary.org/obo/UBERON_0003468	ureteric segment of renal artery		A testicular artery that supplies a right testicle.
http://purl.obolibrary.org/obo/UBERON_0001189	left testicular artery	http://purl.obolibrary.org/obo/UBERON_0003468	ureteric segment of renal artery		A testicular artery that supplies a left testicle.
http://purl.obolibrary.org/obo/UBERON_0001190	ovarian artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies an ovary.
http://purl.obolibrary.org/obo/UBERON_0001191	common iliac artery	http://purl.obolibrary.org/obo/UBERON_0012254	abdominal aorta artery		The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001193	hepatic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies the liver.
http://purl.obolibrary.org/obo/UBERON_0001194	splenic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies the spleen.
http://purl.obolibrary.org/obo/UBERON_0001199	mucosa of stomach	http://purl.obolibrary.org/obo/UBERON_0004786	gastrointestinal system mucosa		The mucosal layer that lines the stomach.
http://purl.obolibrary.org/obo/UBERON_0001200	submucosa of stomach	http://purl.obolibrary.org/obo/UBERON_0018257	submucosa of digestive tract		The fibrous connective tissue layer beneath the stomach mucosa.
http://purl.obolibrary.org/obo/UBERON_0001201	serosa of stomach	http://purl.obolibrary.org/obo/UBERON_0004782	gastrointestinal system serosa		The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum.
http://purl.obolibrary.org/obo/UBERON_0001202	pyloric sphincter	http://purl.obolibrary.org/obo/UBERON_0011185	gastrointestinal sphincter		A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP].
http://purl.obolibrary.org/obo/UBERON_0001204	mucosa of small intestine	http://purl.obolibrary.org/obo/UBERON_0001242	intestinal mucosa		A mucosa that is part of a small intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001205	submucosa of small intestine	http://purl.obolibrary.org/obo/UBERON_0009566	intestinal submucosa		Submucosal tissue in the small intestines.
http://purl.obolibrary.org/obo/UBERON_0001206	serosa of small intestine	http://purl.obolibrary.org/obo/UBERON_0001243	serosa of intestine		A serous membrane that is part of a small intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001207	mucosa of large intestine	http://purl.obolibrary.org/obo/UBERON_0001242	intestinal mucosa		A mucosa that is part of a large intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001208	submucosa of large intestine	http://purl.obolibrary.org/obo/UBERON_0009566	intestinal submucosa		A submucosa that is part of a large intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001209	serosa of large intestine	http://purl.obolibrary.org/obo/UBERON_0001243	serosa of intestine		A serous membrane that is part of a large intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001212	duodenal gland	http://purl.obolibrary.org/obo/UBERON_0011148	submucosal gland		A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP].
http://purl.obolibrary.org/obo/UBERON_0001213	intestinal villus	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold.
http://purl.obolibrary.org/obo/UBERON_0001215	inferior mesenteric vein	http://purl.obolibrary.org/obo/UBERON_0005617	mesenteric vein		A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001216	jejunal vein	http://purl.obolibrary.org/obo/UBERON_0002017	portal vein		A tributary of the superior mesenteric vein that drains the jejunum.
http://purl.obolibrary.org/obo/UBERON_0001217	ileal vein	http://purl.obolibrary.org/obo/UBERON_0002017	portal vein		The veins that drain blood from the ileum into the superior mesenteric vein.
http://purl.obolibrary.org/obo/UBERON_0001221	transversus abdominis muscle	http://purl.obolibrary.org/obo/UBERON_0002461	anterior abdominal wall muscle		The lateral abdominal wall muscle that is deep to the internal oblique.
http://purl.obolibrary.org/obo/UBERON_0001222	right ureter	http://purl.obolibrary.org/obo/UBERON_0000056	ureter		An ureter that is part of a right side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001223	left ureter	http://purl.obolibrary.org/obo/UBERON_0000056	ureter		An ureter that is part of a left side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001225	cortex of kidney	http://purl.obolibrary.org/obo/UBERON_0001851	cortex		Outer cortical portion of the kidney, between the renal capsule and the renal medulla.
http://purl.obolibrary.org/obo/UBERON_0001228	renal papilla	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Tip of renal pyramid projecting into a minor calyx.
http://purl.obolibrary.org/obo/UBERON_0001229	renal corpuscle	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		The structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron.
http://purl.obolibrary.org/obo/UBERON_0001230	glomerular capsule	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus.
http://purl.obolibrary.org/obo/UBERON_0001231	nephron tubule	http://purl.obolibrary.org/obo/UBERON_0009773	renal tubule		An epithelial tube that is part of the nephron, the functional part of the kidney.
http://purl.obolibrary.org/obo/UBERON_0001233	right adrenal gland	http://purl.obolibrary.org/obo/UBERON_0002369	adrenal gland		An adrenal gland that is in the right side of the abdomen.
http://purl.obolibrary.org/obo/UBERON_0001234	left adrenal gland	http://purl.obolibrary.org/obo/UBERON_0002369	adrenal gland		An adrenal gland that is in the left side of the abdomen.
http://purl.obolibrary.org/obo/UBERON_0001238	lamina propria of small intestine	http://purl.obolibrary.org/obo/UBERON_0004780	gastrointestinal system lamina propria		Lamina propria that is part_of the small intestine.
http://purl.obolibrary.org/obo/UBERON_0001241	crypt of Lieberkuhn of small intestine	http://purl.obolibrary.org/obo/UBERON_0001983	crypt of Lieberkuhn		The tubular intestinal glands found in the mucosal membranes of the small intestine.
http://purl.obolibrary.org/obo/UBERON_0001242	intestinal mucosa	http://purl.obolibrary.org/obo/UBERON_0004786	gastrointestinal system mucosa		Mucosal layer that lines the intestine.
http://purl.obolibrary.org/obo/UBERON_0001243	serosa of intestine	http://purl.obolibrary.org/obo/UBERON_0004782	gastrointestinal system serosa		A serous membrane that is part of a wall of intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001246	interlobular bile duct	http://purl.obolibrary.org/obo/UBERON_0003704	intrahepatic bile duct		The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad.
http://purl.obolibrary.org/obo/UBERON_0001247	falciform ligament	http://purl.obolibrary.org/obo/UBERON_0013139	ligament of liver		A ligament that attaches the liver to the anterior body wall. It is a broad and thin antero-posterior peritoneal fold, falciform in shape, its base being directed downward and backward and its apex upward and backward. It is a remnant of the ventral mesentery of the fetus. It is situated in an antero-posterior plane but lies obliquely, so that one surface faces forward and is in contact with the peritoneum behind the right rectus and the diaphragm, while the other is directed backward and is in contact with the left lobe of the liver. It is attached by its left margin to the under surface of the diaphragm and the posterior surface of the sheath of the right Rectus as low down as the umbilicus; by its right margin it extends from the notch on the anterior margin of the liver, as far back as the posterior surface. It is composed of two layers of peritoneum closely united together. Its base or free edge contains between its layers the round ligament and the paraumbilical veins[WP].
http://purl.obolibrary.org/obo/UBERON_0001249	spleen lymphoid follicle	http://purl.obolibrary.org/obo/UBERON_0000444	lymphoid follicle		The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur.
http://purl.obolibrary.org/obo/UBERON_0001250	red pulp of spleen	http://purl.obolibrary.org/obo/UBERON_1000023	spleen pulp		The parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation.
http://purl.obolibrary.org/obo/UBERON_0001251	marginal zone of spleen	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens.
http://purl.obolibrary.org/obo/UBERON_0001252	adventitia of ureter	http://purl.obolibrary.org/obo/UBERON_0005742	adventitia		An adventitia that is part of a ureter.
http://purl.obolibrary.org/obo/UBERON_0001253	lamina propria of ureter	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a ureter [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001256	wall of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		An anatomical wall that lines the insider of a urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0001259	mucosa of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		The mucous membrane lining the urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0001260	serosa of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		A serous membrane that is part of a urinary bladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001261	lamina propria of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a urinary bladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001262	wall of intestine	http://purl.obolibrary.org/obo/UBERON_0000328	gut wall		An anatomical wall that is part of a intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001263	pancreatic acinus	http://purl.obolibrary.org/obo/UBERON_0013232	serous acinus		The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct.
http://purl.obolibrary.org/obo/UBERON_0001265	trabecula of spleen	http://purl.obolibrary.org/obo/UBERON_0000440	trabecula		A trabecula that is part of a spleen.
http://purl.obolibrary.org/obo/UBERON_0001268	peritoneal fluid	http://purl.obolibrary.org/obo/UBERON_0036217	coelomic fluid		Transudate contained in the peritoneal cavity.
http://purl.obolibrary.org/obo/UBERON_0001269	acetabular part of hip bone	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The acetabulum is a concave surface of the pelvis. The head of the femur meets with the pelvis at the acetabulum, forming the hip joint. There are three bones of the os coxae (hip bone) that come together to form the acetabulum. Contributing a little more than two-fifths of the structure is the ischium, which provides lower and side boundaries to the acetabulum. The ilium forms the upper boundary, providing a little less than two-fifths of the structure of the acetabulum. The rest is formed by the pubis, near the midline. It is bounded by a prominent uneven rim, which is thick and strong above, and serves for the attachment of the acetabular labrum, which reduces its opening, and deepens the surface for formation of the hip joint. At the lower part of the acetabulum is the acetabular notch, which is continuous with a circular depression, the acetabular fossa, at the bottom of the cavity of the acetabulum. The rest of the acetabulum is formed by a curved, crescent-moon shaped surface, the lunate surface, where the joint is made with the head of the femur. Its counterpart in the pectoral girdle is the glenoid fossa.[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001270	bony pelvis	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		A ring of bone formed by the sacrum and the first few coccygeal vertebrae as the roof, the pubis and ischia as the floor and the ilia and the acetabular part of the ischia as the walls.
http://purl.obolibrary.org/obo/UBERON_0001271	pelvic girdle region	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions.
http://purl.obolibrary.org/obo/UBERON_0001272	innominate bone	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001273	ilium	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Paired endochondral bone that is the dorsal-most of the pelvic bones, offering attachment areas for gluteal muscles on its main surface [PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0001274	ischium	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Endochondral bone that is paired, forming the posterior part of the pelvis, articulating with the pubis and ilium.
http://purl.obolibrary.org/obo/UBERON_0001275	pubis	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A paired endochondral bone making up the anteroventral region of the tripartite pelvic girdle forming part of the ventral edge of the acetabulum. The origin site of many proximal hindlimb muscles. [PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0001276	epithelium of stomach	http://purl.obolibrary.org/obo/UBERON_0015833	foregut epithelium		The epithelial layer of the stomach .
http://purl.obolibrary.org/obo/UBERON_0001277	intestinal epithelium	http://purl.obolibrary.org/obo/UBERON_0004808	gastrointestinal system epithelium		Epithelial layer that lines the intestine.
http://purl.obolibrary.org/obo/UBERON_0001278	epithelium of large intestine	http://purl.obolibrary.org/obo/UBERON_0001277	intestinal epithelium		An epithelium that is part of a large intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001279	portal triad	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.
http://purl.obolibrary.org/obo/UBERON_0001280	liver parenchyma	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		The functional units of the liver including the lobules.
http://purl.obolibrary.org/obo/UBERON_0001281	hepatic sinusoid	http://purl.obolibrary.org/obo/UBERON_0015796	liver blood vessel		Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers.
http://purl.obolibrary.org/obo/UBERON_0001282	intralobular bile duct	http://purl.obolibrary.org/obo/UBERON_0014716	interlobular duct		The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.
http://purl.obolibrary.org/obo/UBERON_0001285	nephron	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP].
http://purl.obolibrary.org/obo/UBERON_0001294	inner medulla of kidney	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Innermost region of the mammalian kidney.
http://purl.obolibrary.org/obo/UBERON_0001297	serosa of uterus	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Outer serosa layer of the uterus.
http://purl.obolibrary.org/obo/UBERON_0001302	right fallopian tube	http://purl.obolibrary.org/obo/UBERON_0003889	fallopian tube		A fallopian tube that is part of a right side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001303	left fallopian tube	http://purl.obolibrary.org/obo/UBERON_0003889	fallopian tube		A fallopian tube that is part of a left side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001304	germinal epithelium of ovary	http://purl.obolibrary.org/obo/UBERON_0004911	epithelium of female gonad		Layer of simple cuboidal cells covering surface of ovary[WP].
http://purl.obolibrary.org/obo/UBERON_0001307	capsule of ovary	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A capsule that surrounds a female gonad.
http://purl.obolibrary.org/obo/UBERON_0001308	external iliac artery	http://purl.obolibrary.org/obo/UBERON_0005609	iliac artery		The external iliac artery is a large artery in the pelvic region that carries blood to the lower limb. The external iliac artery is a paired artery, meaning there is one on each side of the body: a right external iliac artery and left external iliac artery. The external iliac artery is accompanied by the external iliac vein, which is located posterior to the artery. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001309	internal iliac artery	http://purl.obolibrary.org/obo/UBERON_0005609	iliac artery		The internal iliac artery (formerly known as the hypogastric artery) is the main artery of the pelvis. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001310	umbilical artery	http://purl.obolibrary.org/obo/UBERON_0010260	umbilical blood vessel		The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001312	superior vesical artery	http://purl.obolibrary.org/obo/UBERON_0009027	vesical artery		An artery that supplies blood to the upper urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0001316	external iliac vein	http://purl.obolibrary.org/obo/UBERON_0005610	iliac vein		A large vein that connects the femoral vein to the common iliac vein. Their origin is at the inferior margin of the inguinal ligaments and they terminate when they join the internal iliac veins (to form the common iliac veins). Both external iliac veins are accompanied along their course by external iliac arteries. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001317	internal iliac vein	http://purl.obolibrary.org/obo/UBERON_0005610	iliac vein		A vein that begins near the upper part of the greater sciatic foramen, passes upward behind and slightly medial to the hypogastric artery and, at the brim of the pelvis, joins with the external iliac to form the common iliac vein. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001319	vaginal vein	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		One the veins that drains the vaginal venous plexus, into the hypogastric veins. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001325	muscle of pelvis	http://purl.obolibrary.org/obo/UBERON_0005179	pelvic region element		Muscle (organ) which is a part of the pelvis. Examples: levator ani,.
http://purl.obolibrary.org/obo/UBERON_0001328	lobe of prostate	http://purl.obolibrary.org/obo/UBERON_0009912	anatomical lobe		A portion of a prostate that forms a lobe.
http://purl.obolibrary.org/obo/UBERON_0001330	pampiniform plexus	http://purl.obolibrary.org/obo/UBERON_0001593	venous plexus		The pampiniform plexus is a network of many small veins found in the male spermatic cord. It is formed by the union of multiple spermatic veins from the back of the testis and tributaries from the epididymis. The veins of the plexus ascend along the cord in front of the ductus deferens. Below the subcutaneous inguinal ring they unite to form three or four veins, which pass along the inguinal canal, and, entering the abdomen through the abdominal inguinal ring, coalesce to form two veins. These again unite to form a single vein, the testicular vein, which opens on the right side into the inferior vena cava, at an acute angle, and on the left side into the left renal vein, at a right angle. The pampinoform plexus forms the chief mass of the cord. In addition to its function in venous return from the testes, the pampiniform plexus also plays a role in the temperature regulation of the testes. It acts as a heat exchanger, cooling blood in adjacent arteries. An abnormal enlargement of the pampiniform plexus is a medical condition called varicocele. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001331	skin of penis	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A zone of skin that is part of a penis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001332	prepuce of penis	http://purl.obolibrary.org/obo/UBERON_0011374	prepuce		A retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect.
http://purl.obolibrary.org/obo/UBERON_0001333	male urethra	http://purl.obolibrary.org/obo/UBERON_0000057	urethra		A urethra that is part of a male reproductive system.
http://purl.obolibrary.org/obo/UBERON_0001334	female urethra	http://purl.obolibrary.org/obo/UBERON_0000057	urethra		A urethra that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0001338	urethral gland	http://purl.obolibrary.org/obo/UBERON_0000414	mucous gland		Any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine.
http://purl.obolibrary.org/obo/UBERON_0001343	seminiferous tubule of testis	http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system		The tubules in the testes where spermatogenesis occurs.
http://purl.obolibrary.org/obo/UBERON_0001344	epithelium of vagina	http://purl.obolibrary.org/obo/UBERON_0004804	oviduct epithelium		The epithelial layer of the vagina.
http://purl.obolibrary.org/obo/UBERON_0001350	coccyx	http://purl.obolibrary.org/obo/UBERON_0008001	irregular bone		A collection of caudal vertebrae in the coccygeal region that are fused and part of the bony pelvis.
http://purl.obolibrary.org/obo/UBERON_0001351	lacrimal sac	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		The upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue.
http://purl.obolibrary.org/obo/UBERON_0001352	external acoustic meatus	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter.
http://purl.obolibrary.org/obo/UBERON_0001353	anal region	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		The anus and surrounding regions. Encompasses both internal and external regions, where present.
http://purl.obolibrary.org/obo/UBERON_0001355	deep femoral artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The profunda femoris artery (also known as the deep femoral artery, or the deep artery of the thigh) is a branch of the femoral artery that, as its name suggests, travels more deeply (posteriorly) than the rest of the femoral artery. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001356	medial circumflex femoral artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The medial circumflex femoral artery (internal circumflex artery, medial femoral circumflex artery) is an artery in the upper thigh that helps supply blood to the neck of the femur. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001359	cerebrospinal fluid	http://purl.obolibrary.org/obo/UBERON_0007779	transudate		A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord.
http://purl.obolibrary.org/obo/UBERON_0001363	great saphenous vein	http://purl.obolibrary.org/obo/UBERON_0007318	saphenous vein		The great saphenous vein (GSV), also greater saphenous vein, is the large (subcutaneous) superficial vein of the leg and thigh. The terms 'safaina' (Greek) and 'el safin' (Arabic) have both been claimed as the origin for the word 'saphenous'. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001365	sacro-iliac joint	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The joint in the bony pelvis between the sacrum and the ilium of the pelvis, which are joined by strong ligaments.
http://purl.obolibrary.org/obo/UBERON_0001366	parietal peritoneum	http://purl.obolibrary.org/obo/UBERON_0022351	parietal serous membrane		The outer layer of peritoneum that is attached to the abdominal and pelvic walls.
http://purl.obolibrary.org/obo/UBERON_0001377	quadriceps femoris	http://purl.obolibrary.org/obo/UBERON_0003663	hindlimb muscle		One of the muscles belong to the group consisting of the rectus femoris and the three heads of the vastus (lateralis, medialis, intermedius).
http://purl.obolibrary.org/obo/UBERON_0001378	rectus femoris	http://purl.obolibrary.org/obo/UBERON_0001377	quadriceps femoris		The Rectus femoris muscle is one of the four quadriceps muscles of the human body. (The others are the vastus medialis, the vastus intermedius, and the vastus lateralis. All four combine to form the quadriceps tendon, which inserts into the patella and continues as the patellar ligament. ) The Rectus femoris is situated in the middle of the front of the thigh; it is fusiform in shape, and its superficial fibers are arranged in a bipenniform manner, the deep fibers running straight down to the deep aponeurosis. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001379	vastus lateralis	http://purl.obolibrary.org/obo/UBERON_0001377	quadriceps femoris		The Vastus lateralis (Vastus externus) is the largest part of the Quadriceps femoris. It arises by a broad aponeurosis, which is attached to the upper part of the intertrochanteric line, to the anterior and inferior borders of the greater trochanter, to the lateral lip of the gluteal tuberosity, and to the upper half of the lateral lip of the linea aspera; this aponeurosis covers the upper three-fourths of the muscle, and from its deep surface many fibers take origin. A few additional fibers arise from the tendon of the Glutæus maximus, and from the lateral intermuscular septum between the Vastus lateralis and short head of the Biceps femoris. The fibers form a large fleshy mass, which is attached to a strong aponeurosis, placed on the deep surface of the lower part of the muscle: this aponeurosis becomes contracted and thickened into a flat tendon inserted into the lateral border of the patella, blending with the Quadriceps femoris tendon, and giving an expansion to the capsule of the knee-joint. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001380	vastus medialis	http://purl.obolibrary.org/obo/UBERON_0001377	quadriceps femoris		The vastus medialis, often called the 'teardrop' muscle, is a medially located muscle of the quadriceps. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001383	muscle of leg	http://purl.obolibrary.org/obo/UBERON_0003663	hindlimb muscle		A muscle that is part of the region of the hindlimb between the pelvis and ankle.
http://purl.obolibrary.org/obo/UBERON_0001384	primary motor cortex	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html.
http://purl.obolibrary.org/obo/UBERON_0001385	tibialis anterior	http://purl.obolibrary.org/obo/UBERON_0008230	tibialis		A muscle that originates in the upper two-thirds of the lateral surface of the tibia and inserts into the medial cuneiform and first metatarsal bones of the foot. Its acts to invert the foot. It is situated on the lateral side of the tibia; it is thick and fleshy above, tendinous below. This muscle overlaps the anterior tibial vessels and deep peroneal nerve in the upper part of the leg. [WP,unvetted]. The M. tibialis cranialis is a muscle that flexes the tarsometatarsus. It originates on the craniodistal aspect of the femur and proximal tibiotarsus and inserts on the cranial surface of the tarsometarsus[EvoWiki].
http://purl.obolibrary.org/obo/UBERON_0001388	gastrocnemius	http://purl.obolibrary.org/obo/UBERON_0004256	hindlimb zeugopod muscle		The most superficial muscle of the triceps surae group, in the posterior portion of the lower hindleg.
http://purl.obolibrary.org/obo/UBERON_0001389	soleus muscle	http://purl.obolibrary.org/obo/UBERON_0004256	hindlimb zeugopod muscle		A deep muscle of the triceps surae group, in the superficial posterior compartment of the leg.
http://purl.obolibrary.org/obo/UBERON_0001394	axillary artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		Artery that supplies the axilla.
http://purl.obolibrary.org/obo/UBERON_0001397	subscapular artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The subscapular artery, the largest branch of the axillary artery, arises at the lower border of the Subscapularis, which it follows to the inferior angle of the scapula, where it anastomoses with the lateral thoracic and intercostal arteries and with the descending branch of the transverse cervical, and ends in the neighboring muscles. About 4 cm. from its origin it gives off two branches, first the scapular circumflex artery and then the thoracodorsal artery. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001415	skin of pelvis	http://purl.obolibrary.org/obo/UBERON_0003836	abdominal segment skin		A zone of skin that is part of a pelvis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001416	skin of abdomen	http://purl.obolibrary.org/obo/UBERON_0003836	abdominal segment skin		A zone of skin that is part of an abdomen [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001417	skin of neck	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is part of a neck [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001418	skin of thorax	http://purl.obolibrary.org/obo/UBERON_0001085	skin of trunk		A zone of skin that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001419	skin of limb	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001421	pectoral girdle region	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions.
http://purl.obolibrary.org/obo/UBERON_0001422	facial lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		A lymphatic vessel that is part of a face [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001423	radius bone	http://purl.obolibrary.org/obo/UBERON_0015001	radius endochondral element		The major preaxial endochondral bone in the anterior zeugopod[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0001424	ulna	http://purl.obolibrary.org/obo/UBERON_0015003	ulna endochondral element		The major postaxial endochondral bone in the anterior zeugopod[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0001427	radiale	http://purl.obolibrary.org/obo/UBERON_0001480	proximal carpal bone		Endochondral proximal carpal bone articulating with the radius.
http://purl.obolibrary.org/obo/UBERON_0001428	intermedium	http://purl.obolibrary.org/obo/UBERON_0001480	proximal carpal bone		Endochondral carpal bone articulating with the ulnare and the radiale.
http://purl.obolibrary.org/obo/UBERON_0001434	skeletal system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.
http://purl.obolibrary.org/obo/UBERON_0001435	carpal bone	http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element		A bone that is part of the carpal skeleton. Examples: scaphoid, lunate, capitate[cjm].
http://purl.obolibrary.org/obo/UBERON_0001436	phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element		A phalanx that is part of a forelimb autopod[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		The head of a long bone that articulates with a neighboring skeletal element and is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united[MESH,modified].
http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		Zone of long bone that is between the epiphysis and diaphysis. Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA].
http://purl.obolibrary.org/obo/UBERON_0001439	compact bone tissue	http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue		The outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae.
http://purl.obolibrary.org/obo/UBERON_0001440	forelimb skeleton	http://purl.obolibrary.org/obo/UBERON_0007272	pectoral appendage skeleton		The collection of all skeletal elements in a free forelimb region. Excludes the pectoral girdle.
http://purl.obolibrary.org/obo/UBERON_0001441	hindlimb skeleton	http://purl.obolibrary.org/obo/UBERON_0007273	pelvic appendage skeleton		Subdivision of skeleton consisting of all skeletal elements in an hindlimb region.
http://purl.obolibrary.org/obo/UBERON_0001442	skeleton of manus	http://purl.obolibrary.org/obo/UBERON_0006717	autopodial skeleton		Subdivision of skeleton that is the collection of all skeletal elements in a manus, which is the distal section of the anterior forelimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the wrist, palm, and fingers)[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0001443	chest	http://purl.obolibrary.org/obo/UBERON_0009569	subdivision of trunk		Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA].
http://purl.obolibrary.org/obo/UBERON_0001445	skeleton of pes	http://purl.obolibrary.org/obo/UBERON_0006717	autopodial skeleton		Subdivision of skeleton that is the collection of all skeletal elements in a pes, which is the distal section of the posterior hindlimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the ankle, sole, and toes)[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0001446	fibula	http://purl.obolibrary.org/obo/UBERON_0015013	fibula endochondral element		The major postaxial endochondral bone in the posterior zeugopod[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0001447	tarsal bone	http://purl.obolibrary.org/obo/UBERON_0015050	tarsus endochondral element		A bone that is part of the tarsal skeleton. Examples: calcaneus, talus, centralia.
http://purl.obolibrary.org/obo/UBERON_0001448	metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		The metatarsus or metatarsal bones are a group of five long bones in the pes located between the tarsal bones of the hind- and mid-pes and the phalanges of the toes. Lacking individual names, the metatarsal bones are numbered from the medial side (side of big toe): the first, second, third, fourth, and fifth metatarsal. The metatarsals are analogous to the metacarpal bones of the manus. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001449	phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element		A phalanx that is part of a hindlimb autopod[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001450	calcaneus	http://purl.obolibrary.org/obo/UBERON_0015014	calcaneum endochondral element		The postaxial bone of the proximal tarsals series[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0001451	navicular bone of pes	http://purl.obolibrary.org/obo/UBERON_0012131	centrale		The oval-shaped tarsal bone found between the talus and the 3 cuneiform bones.
http://purl.obolibrary.org/obo/UBERON_0001452	distal tarsal bone 1	http://purl.obolibrary.org/obo/UBERON_0015102	distal tarsal bone 1 endochondral element		Endochondral tarsal bone articulating with centralia and metatarsal 1.
http://purl.obolibrary.org/obo/UBERON_0001453	distal tarsal bone 2	http://purl.obolibrary.org/obo/UBERON_0015105	distal tarsal bone 2 endochondral element		Endochondral tarsal bone articulating with centralia and metatarsal 2.
http://purl.obolibrary.org/obo/UBERON_0001454	distal tarsal bone 3	http://purl.obolibrary.org/obo/UBERON_0015108	distal tarsal bone 3 endochondral element		Endochondral tarsal bone articulating with centralia and metatarsal 3.
http://purl.obolibrary.org/obo/UBERON_0001455	cuboid bone	http://purl.obolibrary.org/obo/UBERON_0010721	distal tarsal bone		A tarsal bone that is formed from distal tarsals 4 and 5. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001457	skin of eyelid	http://purl.obolibrary.org/obo/UBERON_1000021	skin of face		A zone of skin that is part of a eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001458	skin of lip	http://purl.obolibrary.org/obo/UBERON_1000021	skin of face		A zone of skin that is part of a lip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001459	skin of external ear	http://purl.obolibrary.org/obo/UBERON_0001084	skin of head		A zone of skin that is part of a external ear [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001460	arm	http://purl.obolibrary.org/obo/UBERON_0008785	upper limb segment		The part of the forelimb extending from the shoulder to the autopod[cjm].
http://purl.obolibrary.org/obo/UBERON_0001461	elbow	http://purl.obolibrary.org/obo/UBERON_0008785	upper limb segment		The elbow is the region surrounding the elbow-joint-the ginglymus or hinge joint in the middle of the arm. Three bones form the elbow joint: the humerus of the upper arm, and the paired radius and ulna of the forearm. The bony prominence at the very tip of the elbow is the olecranon process of the ulna, and the inner aspect of the elbow is called the antecubital fossa. [WP,unvetted,human-specific].
http://purl.obolibrary.org/obo/UBERON_0001463	manual digit 1	http://purl.obolibrary.org/obo/UBERON_0019231	manual digit 1 or 5		1st (preaxial) digit of the manus[Wikipedia].
http://purl.obolibrary.org/obo/UBERON_0001464	hip	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001465	knee	http://purl.obolibrary.org/obo/UBERON_0008784	lower limb segment		A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod.
http://purl.obolibrary.org/obo/UBERON_0001466	pedal digit	http://purl.obolibrary.org/obo/UBERON_0002544	digit		A digit that is part of a pes (foot).
http://purl.obolibrary.org/obo/UBERON_0001467	shoulder	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle).
http://purl.obolibrary.org/obo/UBERON_0001468	intervertebral joint	http://purl.obolibrary.org/obo/UBERON_0002216	symphysis		The joint between adjacent vertebral bodies. May be composed of the nucleus pulposus, annular ligament, and the anterior and posterior longitudinal ligaments.
http://purl.obolibrary.org/obo/UBERON_0001469	sternoclavicular joint	http://purl.obolibrary.org/obo/UBERON_0011108	synovial joint of pectoral girdle		The sternoclavicular articulation is a double arthrodial joint composed of two portions separated by an articular disc. The parts entering into its formation are the sternal end of the clavicle, the upper and lateral part of the manubrium sterni, and the cartilage of the first rib, visible from the outside as the suprasternal notch. The articular surface of the clavicle is much larger than that of the sternum, and is invested with a layer of cartilage, which is considerably thicker than that on the latter bone. The ligaments of this joint are: Articular capsule Anterior sternoclavicular ligament Posterior sternoclavicular ligament Interclavicular ligament Costoclavicular ligament Articular disk [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001470	glenohumeral joint	http://purl.obolibrary.org/obo/UBERON_0016884	shoulder joint		The glenohumeral joint, commonly known as the shoulder joint, is a multiaxial synovial ball and socket joint and involves articulation between the glenoid fossa of the scapula (shoulder blade) and the head of the humerus (upper arm bone). [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001471	skin of prepuce of penis	http://purl.obolibrary.org/obo/UBERON_0001331	skin of penis		The loose fold of skin that covers the penis.
http://purl.obolibrary.org/obo/UBERON_0001472	vaginal venous plexus	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		The vaginal plexuses are placed at the sides of the vagina; they communicate with the uterine, vesical, and hemorrhoidal plexuses, and are drained by the vaginal veins, one on either side, into the hypogastric veins. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0000055	vessel		A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO].
http://purl.obolibrary.org/obo/UBERON_0001474	bone element	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Skeletal element that is composed of bone tissue.
http://purl.obolibrary.org/obo/UBERON_0001476	deltoid	http://purl.obolibrary.org/obo/UBERON_0034908	scapular muscle		A muscle of shoulder which attaches to the scapula, clavicle and humerus.[FMA,generalized].
http://purl.obolibrary.org/obo/UBERON_0001479	sesamoid bone	http://purl.obolibrary.org/obo/UBERON_0013631	sesamoid element		A sesamoid element that is composed of bone tissue.
http://purl.obolibrary.org/obo/UBERON_0001480	proximal carpal bone	http://purl.obolibrary.org/obo/UBERON_0015078	proximal carpal endochondral element		A carpal bone that proximally_connected_to a forelimb zeugopod skeleton.
http://purl.obolibrary.org/obo/UBERON_0001481	distal carpal bone	http://purl.obolibrary.org/obo/UBERON_0018102	distal mesopodial bone		A distal carpal endochondral element that is composed primarily of a bone tissue.
http://purl.obolibrary.org/obo/UBERON_0001482	muscle of shoulder	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Any muscle organ that is part of a shoulder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001483	skin of shoulder	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is part of a shoulder region.
http://purl.obolibrary.org/obo/UBERON_0001484	articular capsule	http://purl.obolibrary.org/obo/UBERON_0000094	membrane organ		An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001485	knee joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001486	hip joint	http://purl.obolibrary.org/obo/UBERON_0011107	synovial joint of pelvic girdle		A synovial joint that connects the femur to the acetbulum of the innominate bone.
http://purl.obolibrary.org/obo/UBERON_0001487	pes joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		A skeletal joint that is part of a pes [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001488	ankle joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		A joint that connects the hindlimb autopod and zeugopod skeletons.
http://purl.obolibrary.org/obo/UBERON_0001489	manus joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		A skeletal joint that is part of a manus (hand) [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001490	elbow joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		A joint that connects the forelimb zeugopod and stylopod skeletons[Obol].
http://purl.obolibrary.org/obo/UBERON_0001491	wrist joint	http://purl.obolibrary.org/obo/UBERON_0001489	manus joint		A joint connecting the forelimb zeugopod skeleton with the carpal skeleton.
http://purl.obolibrary.org/obo/UBERON_0001492	radial nerve	http://purl.obolibrary.org/obo/UBERON_0003433	arm nerve		A nerve that supplies the upper limb, including the triceps brachii muscle of the arm, as well as all 12 muscles in the posterior osteofascial compartment of the forearm, as well as the associated joints and overlying skin.
http://purl.obolibrary.org/obo/UBERON_0001493	axillary nerve	http://purl.obolibrary.org/obo/UBERON_0003433	arm nerve		The axillary nerve is a nerve of the human body, that comes off the posterior cord of the brachial plexus at the level of the axilla (armpit) and carries nerve fibers from C5 and C6. The axillary nerve travels through the quadrangular space with the posterior circumflex humeral artery and vein. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001495	pectoral muscle	http://purl.obolibrary.org/obo/UBERON_0008196	muscle of pectoral girdle		Muscles of the upper chest. The term may refer to one of two muscles, the pectoralis major and pectoralis minor. The former is a thick muscle in the anterior portion of the chest. Its action involves flexion, medial rotation, and adduction of the humerus. The latter is a thin muscle located beneath the pectoralis major. Its action involves lowering the scapula and raising the ribs.
http://purl.obolibrary.org/obo/UBERON_0001496	ascending aorta	http://purl.obolibrary.org/obo/UBERON_0001515	thoracic aorta		The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia].
http://purl.obolibrary.org/obo/UBERON_0001497	muscle of pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0010890	pelvic complex muscle		Any muscle organ that is part of a pelvic girdle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001498	muscle of pes	http://purl.obolibrary.org/obo/UBERON_0003663	hindlimb muscle		Any muscle organ that is part of a pes [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001499	muscle of arm	http://purl.obolibrary.org/obo/UBERON_0003662	forelimb muscle		A muscle organ that is part of an arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001500	muscle of manus	http://purl.obolibrary.org/obo/UBERON_0003662	forelimb muscle		Any muscle organ that is part of a manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001502	interosseous muscle of manus	http://purl.obolibrary.org/obo/UBERON_0014375	intrinsic muscle of manus		Any of the interosseous muscles of the manus (hand). This includes the dorsal and plantar interossei.
http://purl.obolibrary.org/obo/UBERON_0001503	dorsal interosseous of manus	http://purl.obolibrary.org/obo/UBERON_0001502	interosseous muscle of manus		The dorsal interossei of the hand are muscles that occupy the space between the metacarpals. There are four dorsal interossei in each hand. They are specified as 'dorsal' to contrast them with the palmar interossei, which are located on the anterior side of the metacarpals. The dorsal interosseous muscles are bipennate, with each muscle arising by two heads from the adjacent sides of the metacarpal bones, but more extensively from the metacarpal bone of the finger into which the muscle is inserted. They are inserted into the bases of the proximal phalanges and into the extensor expansion of the corresponding extensor digitorum tendon. The middle digit has two dorsal interossei insert onto it while the first digit (thumb) and the fifth digit (little finger) have none[WP].
http://purl.obolibrary.org/obo/UBERON_0001507	biceps brachii	http://purl.obolibrary.org/obo/UBERON_0004255	forelimb stylopod muscle		A muscle in the forelimb stylopod which in humans has several functions, the most important being to rotate the forearm and to flex the elbow. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001508	arch of aorta	http://purl.obolibrary.org/obo/UBERON_0001515	thoracic aorta		The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery.
http://purl.obolibrary.org/obo/UBERON_0001509	triceps brachii	http://purl.obolibrary.org/obo/UBERON_0034908	scapular muscle		The triceps brachii muscle (Latin for 'three-headed' muscle of the arm, it is called a three headed muscle because there are three bundles of muscle, each of different origin, joining together at the elbow) is the large muscle on the back of the human upper limb. It is the muscle principally responsible for extension of the elbow joint (i.e. straightening of the arm). Though a similarly-named muscle, the triceps surae, is found on the lower leg, the triceps brachii is commonly called simply the 'triceps'. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001510	skin of knee	http://purl.obolibrary.org/obo/UBERON_0001511	skin of leg		A zone of skin that is part of a knee [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001511	skin of leg	http://purl.obolibrary.org/obo/UBERON_0003532	hindlimb skin		A zone of skin that is part of a leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001512	skin of ankle	http://purl.obolibrary.org/obo/UBERON_0001513	skin of pes		A zone of skin that is part of an ankle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001513	skin of pes	http://purl.obolibrary.org/obo/UBERON_0015790	autopod skin		A zone of skin that is part of a pes [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001514	descending aorta	http://purl.obolibrary.org/obo/UBERON_0005800	section of aorta		The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001515	thoracic aorta	http://purl.obolibrary.org/obo/UBERON_0005800	section of aorta		The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.
http://purl.obolibrary.org/obo/UBERON_0001516	abdominal aorta	http://purl.obolibrary.org/obo/UBERON_0005800	section of aorta		Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001517	skin of elbow	http://purl.obolibrary.org/obo/UBERON_0002427	arm skin		A zone of skin that is part of a elbow [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001518	skin of wrist	http://purl.obolibrary.org/obo/UBERON_0001519	skin of manus		A zone of skin that is part of a wrist [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001519	skin of manus	http://purl.obolibrary.org/obo/UBERON_0015790	autopod skin		A zone of skin that is part of a manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001528	radio-ulnar joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		A joint that connects the radius and the ulna. Examples: proximal and distal radio-ulnar joints.
http://purl.obolibrary.org/obo/UBERON_0001529	brachiocephalic artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery.
http://purl.obolibrary.org/obo/UBERON_0001530	common carotid artery plus branches	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm].
http://purl.obolibrary.org/obo/UBERON_0001531	right common carotid artery plus branches	http://purl.obolibrary.org/obo/UBERON_0001530	common carotid artery plus branches		The rightmost of the two common carotid arteries, originating from in the neck from the brachiocephalic trunk.
http://purl.obolibrary.org/obo/UBERON_0001532	internal carotid artery	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP].
http://purl.obolibrary.org/obo/UBERON_0001533	subclavian artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta.
http://purl.obolibrary.org/obo/UBERON_0001534	right subclavian artery	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The subclavian artery that supplies the right pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0001536	left common carotid artery plus branches	http://purl.obolibrary.org/obo/UBERON_0001530	common carotid artery plus branches		The leftmost of the two common carotid arteries, originating from the aortic arch in the thorax.
http://purl.obolibrary.org/obo/UBERON_0001543	popliteal lymph node	http://purl.obolibrary.org/obo/UBERON_0016398	lymph node of lower limb		The lymph nodes which drain the legs; contained in the popliteal fossa.
http://purl.obolibrary.org/obo/UBERON_0001544	popliteal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The popliteal vein course runs alongside the popliteal artery but carries the blood from the knee joint and muscles in the thigh and calf back to the heart. Its origin is defined by the junction of the posterior tibial vein and anterior tibial vein. It drains the peroneal vein before reaching the knee joint and turns into the femoral vein when leaving the adductor canal (also known as Hunter's canal). The popliteal artery extends from the femoral artery behind the popliteal fossa which is the space behind the knee. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001545	anterior tibial vein	http://purl.obolibrary.org/obo/UBERON_0010370	tibial vein		A vein of the lower limb that carries blood from the anterior compartment of the leg to the popliteal vein which is forms when it joins with the posterior tibial vein. Like most deep veins, the anterior tibial vein is accompanied by an artery of the same name, the anterior tibial artery, along its course. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001546	posterior tibial vein	http://purl.obolibrary.org/obo/UBERON_0010370	tibial vein		A vein of the lower limb carries blood from the posterior compartment and plantar surface of the foot to the popliteal vein which it forms when it joins with the anterior tibial vein. Like most deep veins, the posterior tibial vein is accompanied by an artery of the same name, the posterior tibial artery, along its course. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001547	small saphenous vein	http://purl.obolibrary.org/obo/UBERON_0007318	saphenous vein		The small saphenous vein (also lesser saphenous vein), is a relatively large vein of the superficial posterior leg. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001549	dorsal metatarsal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The dorsal metatarsal veins are veins which drain the metatarsus of the foot. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001550	medial marginal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A continuation of the Dorsal venous arch of the foot and is the origin of the long saphenous vein.
http://purl.obolibrary.org/obo/UBERON_0001552	kidney arcuate artery	http://purl.obolibrary.org/obo/UBERON_0003644	kidney arterial blood vessel		One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries.
http://purl.obolibrary.org/obo/UBERON_0001554	skin of hip	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is part of a hip region.
http://purl.obolibrary.org/obo/UBERON_0001555	digestive tract	http://purl.obolibrary.org/obo/UBERON_0000025	tube		A tube extending from the mouth to the anus.
http://purl.obolibrary.org/obo/UBERON_0001556	lower urinary tract	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		Subdivision of urinary system which consists of the urinary bladder and the urethra.
http://purl.obolibrary.org/obo/UBERON_0001562	digastric muscle group	http://purl.obolibrary.org/obo/UBERON_0008571	suprahyoid muscle		A group of muscles (or in some classifications, muscle bellies) that are located under the jaw and attach to the base of the cranium and typically attaches to the hyoid apparatus via a common tendon.
http://purl.obolibrary.org/obo/UBERON_0001564	mylohyoid muscle	http://purl.obolibrary.org/obo/UBERON_0018544	trigeminal nerve muscle		The mylohyoid is a pharyngeal arch I muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to mylohyoid and attaches to the midline raphe linking right and left mylohyoid and the mandible.
http://purl.obolibrary.org/obo/UBERON_0001565	geniohyoid muscle	http://purl.obolibrary.org/obo/UBERON_0011151	jaw depressor muscle		The geniohyoid is a muscle that attaches to the mandible and the hyoid apparatus and is innervated by the first cervical nerve (C1).
http://purl.obolibrary.org/obo/UBERON_0001566	cricothyroid muscle	http://purl.obolibrary.org/obo/UBERON_0006328	laryngeal intrinsic muscle		Intrinsic muscle of the larynx, innervated by the external division of the laryngeal nerve, a branch of the vagus nerve. It attaches to the anterolateral surface of the cricoid cartilage and the external surface of the thyroid cartilage.
http://purl.obolibrary.org/obo/UBERON_0001567	cheek	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		A fleshy subdivision of one side of the face bounded by an eye, ear and the nose.
http://purl.obolibrary.org/obo/UBERON_0001568	muscle of larynx	http://purl.obolibrary.org/obo/UBERON_0003831	respiratory system muscle		The muscles associated with the larynx.
http://purl.obolibrary.org/obo/UBERON_0001571	genioglossus muscle	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue.
http://purl.obolibrary.org/obo/UBERON_0001572	hyoglossus muscle	http://purl.obolibrary.org/obo/UBERON_0001575	extrinsic muscle of tongue		A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII.
http://purl.obolibrary.org/obo/UBERON_0001573	styloglossus	http://purl.obolibrary.org/obo/UBERON_0001575	extrinsic muscle of tongue		The Styloglossus, the shortest and smallest of the three styloid muscles, arises from the anterior and lateral surfaces of the styloid process, near its apex, and from the stylomandibular ligament. Passing downward and forward between the internal and external carotid arteries, it divides upon the side of the tongue near its dorsal surface, blending with the fibers of the Longitudinalis inferior in front of the Hyoglossus; the other, oblique, overlaps the Hyoglossus and decussates with its fibers. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001574	palatoglossus muscle	http://purl.obolibrary.org/obo/UBERON_0003682	palatal muscle		The palatoglossus, glossopalatinus, or palatoglossal muscle is a small fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the glossopalatine arch. It arises from the anterior surface of the soft palate, where it is continuous with the muscle of the opposite side, and passing downward, forward, and lateralward in front of the palatine tonsil, is inserted into the side of the tongue, some of its fibers spreading over the dorsum, and others passing deeply into the substance of the organ to intermingle with the Transversus linguæ. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001575	extrinsic muscle of tongue	http://purl.obolibrary.org/obo/UBERON_0000378	tongue muscle		A muscle organ that attaches the tongue to some other structure.
http://purl.obolibrary.org/obo/UBERON_0001576	intrinsic muscle of tongue	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII.
http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle	http://purl.obolibrary.org/obo/UBERON_0015789	cranial or facial muscle		A muscle innervated by a facial nerve.
http://purl.obolibrary.org/obo/UBERON_0001578	orbicularis oculi muscle	http://purl.obolibrary.org/obo/UBERON_0004277	eye muscle		A circumorbital muscle in the face that closes the eyelid[HP].
http://purl.obolibrary.org/obo/UBERON_0001580	levator labii superioris	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		The levator labii superioris (or quadratus labii superioris) is a broad sheet, the origin of which extends from the side of the nose to the zygomatic bone. Its medial fibers form the angular head, which arises by a pointed extremity from the upper part of the frontal process of the maxilla and passing obliquely downward and lateralward divides into two slips. One of these is inserted into the greater alar cartilage and skin of the nose; the other is prolonged into the lateral part of the upper lip, blending with the infraorbital head and with the Orbicularis oris. The intermediate portion or infraorbital head arises from the lower margin of the orbit immediately above the infraorbital foramen, some of its fibers being attached to the maxilla, others to the zygomatic bone. Its fibers converge, to be inserted into the muscular substance of the upper lip between the angular head and the Caninus. The lateral fibers, forming the zygomatic head, arise from the malar surface of the zygomatic bone immediately behind the zygomaticomaxillary suture and pass downward and medialward to the upper lip. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001581	depressor labii inferioris	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip, orbicularis oris muscle, and mandible, and superficial and lateral to the mentalis muscle. See Diogo et al., 2009; Burrows et al., 2011).
http://purl.obolibrary.org/obo/UBERON_0001582	buccinator muscle	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		The buccinator is a muscle that is attached to the mandible, skin, pterygomandibular raphe and maxilla, and is innervated by Cranial Nerve VII and participates in oropharyngeal behavior.
http://purl.obolibrary.org/obo/UBERON_0001584	left subclavian artery	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The subclavian artery that supplies the left pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0001586	internal jugular vein	http://purl.obolibrary.org/obo/UBERON_0004711	jugular vein		One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001587	subclavian vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The subclavian vein is a paired large vein, one on either side of the body. Their diameter is approximately that of the smallest finger.
http://purl.obolibrary.org/obo/UBERON_0001591	thymic vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains blood from the thymus.
http://purl.obolibrary.org/obo/UBERON_0001592	bronchial vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001593	venous plexus	http://purl.obolibrary.org/obo/UBERON_0005629	vascular plexus		A congregation of multiple veins.
http://purl.obolibrary.org/obo/UBERON_0001597	masseter muscle	http://purl.obolibrary.org/obo/UBERON_0003681	masticatory muscle		Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by masseteric nerve branches of the trigeminal nerve (CN V), and attaches to mandible and zygomatic arch.
http://purl.obolibrary.org/obo/UBERON_0001598	temporalis muscle	http://purl.obolibrary.org/obo/UBERON_0003681	masticatory muscle		Pharyngeal arch 1 muscle that is innervated by the deep temporal branches of the trigeminal nerve and attaches to the wall of the braincase (including the cranial vault) and mandible.
http://purl.obolibrary.org/obo/UBERON_0001599	stapedius muscle	http://purl.obolibrary.org/obo/UBERON_0004113	muscle of auditory ossicle		The muscle that stabilizes the stapes bone. The stapedius emerges from a pinpoint foramen in the apex of the pyramidal eminence (a hollow, cone-shaped prominence in the posterior wall of the tympanic cavity), and inserts into the neck of the stapes. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001600	tensor tympani	http://purl.obolibrary.org/obo/UBERON_0018544	trigeminal nerve muscle		The larger of the two muscles of the tympanic cavity, is contained in the bony canal above the osseous portion of the auditory tube. Its role is to dampen sounds produced from chewing. It arises from the cartilaginous portion of the auditory tube and the adjoining part of the great wing of the sphenoid, as well as from the osseous canal in which it is contained. Passing backward through the canal, it ends in a slender tendon which enters the tympanic cavity, makes a sharp bend around the extremity of the septum, known as the processus cochleariformis[1], and is inserted into the manubrium of the malleus, near its root[WP].
http://purl.obolibrary.org/obo/UBERON_0001602	medial rectus extraocular muscle	http://purl.obolibrary.org/obo/UBERON_0006533	rectus extraocular muscle		The medial rectus muscle is a muscle in the orbit. As with most of the muscles of the orbit, it is innervated by the inferior division of the oculomotor nerve (Cranial Nerve III). This muscle shares an origin with several other extrinsic eye muscles, the anulus tendineus, or common tendon. It is the largest of the extraocular muscles and its only action is adduction of the eyeball. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001603	lateral rectus extra-ocular muscle	http://purl.obolibrary.org/obo/UBERON_0006533	rectus extraocular muscle		The lateral rectus muscle is a muscle in the orbit. It is one of six extraocular muscles that control the movements of the eye (abduction in this case) and the only muscle innervated by the abducens nerve, cranial nerve VI. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001604	levator palpebrae superioris	http://purl.obolibrary.org/obo/UBERON_0001601	extra-ocular muscle		The levator palpebrae superioris (or levator muscle of upper eyelid) is the muscle in the orbit that elevates the superior (upper) eyelid. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001605	ciliary muscle	http://purl.obolibrary.org/obo/UBERON_0011222	intra-ocular muscle		The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001607	sphincter pupillae	http://purl.obolibrary.org/obo/UBERON_0007521	smooth muscle sphincter		A sphincter muscle that is part of the iris.
http://purl.obolibrary.org/obo/UBERON_0001608	dilatator pupillae	http://purl.obolibrary.org/obo/UBERON_0004234	iris smooth muscle		A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001610	lingual artery	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP].
http://purl.obolibrary.org/obo/UBERON_0001611	sublingual artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		A branch of the lingual artery that supplies the sublingual gland.
http://purl.obolibrary.org/obo/UBERON_0001612	facial artery	http://purl.obolibrary.org/obo/UBERON_0035398	branch of external carotid artery		A branch of the external carotid artery that supplies structures of the face. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001613	occipital artery	http://purl.obolibrary.org/obo/UBERON_0035398	branch of external carotid artery		The occipital artery arises opposite the facial artery, its path is below the posterior belly of digastric to the occipital region. This artery supplies blood to the back of the scalp and sterno-mastoid muscles. Other muscles it supplies are deep muscles in the back and neck. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001616	maxillary artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001617	mental artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The mental branch of inferior alveolar artery escapes with the nerve at the mental foramen, supplies the chin, and anastomoses with the submental and inferior labial arteries. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001618	buccal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The buccal artery (buccinator artery) is small and runs obliquely forward, between the Pterygoideus internus and the insertion of the Temporalis, to the outer surface of the Buccinator, to which it is distributed, anastomosing with branches of the external maxillary and with the infraorbital. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001619	ophthalmic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001620	central retinal artery	http://purl.obolibrary.org/obo/UBERON_0003501	retina blood vessel		The central retinal artery (retinal artery) branches off the ophthalmic artery, running inferior to the optic nerve within its dural sheath to the eyeball. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001622	lacrimal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The lacrimal artery arises close to the optic foramen, and is one of the largest branches derived from the ophthalmic artery: not infrequently it is given off before the artery enters the orbit. It accompanies the lacrimal nerve along the upper border of the Lateral Rectus, supplies the lacrimal gland. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001623	dorsal nasal artery	http://purl.obolibrary.org/obo/UBERON_0015156	terminal branch of ophthalmic artery		The dorsal nasal artery (nasal artery) is an artery of the head. It is one of the two terminal branches of the ophthalmic artery. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001627	middle cerebral artery	http://purl.obolibrary.org/obo/UBERON_0004449	cerebral artery		The middle cerebral artery (MCA) is one of the three major paired arteries that supplies blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it then branches and projects to many parts of the lateral cerebral cortex. It also supplies blood to the anterior temporal lobes and the insular cortices. The left and right MCAs rise from trifurcations of the internal carotid arteries and thus are connected to the anterior cerebral arteries and the posterior communicating arteries, which connect to the posterior cerebral arteries. The MCAs are not considered a part of the Circle of Willis. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001628	posterior communicating artery	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		One of a pair of right-sided and left-sided blood vessels in the circle of Willis. It connects the three cerebral arteries of the same side. Anteriorly, it is one portion of the terminal trifurcation of the internal carotid artery. The anterior cerebral artery and the middle cerebral artery are the other two branches of the trifurcation. Posteriorly, it communicates with the posterior cerebral artery.
http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ	http://purl.obolibrary.org/obo/UBERON_0005090	muscle structure		Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO].
http://purl.obolibrary.org/obo/UBERON_0001631	thoracic duct	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins.
http://purl.obolibrary.org/obo/UBERON_0001635	superior cerebellar artery	http://purl.obolibrary.org/obo/UBERON_0003472	cerebellar artery		The superior cerebellar artery (SCA) arises near the termination of the basilar artery. It passes lateralward, immediately below the oculomotor nerve, which separates it from the posterior cerebral artery, winds around the cerebral peduncle, close to the trochlear nerve, and, arriving at the upper surface of the cerebellum, divides into branches which ramify in the pia mater and anastomose with those of the inferior cerebellar arteries. Several branches are given to the pineal body, the anterior medullary velum, and the tela chorioidea of the third ventricle. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001639	hepatic portal vein	http://purl.obolibrary.org/obo/UBERON_0002017	portal vein		A portal vein that transports nutrients from the digestive tract to the liver[Kardong].
http://purl.obolibrary.org/obo/UBERON_0001640	celiac artery	http://purl.obolibrary.org/obo/UBERON_0012254	abdominal aorta artery		The first major branch of the abdominal aorta.
http://purl.obolibrary.org/obo/UBERON_0001641	transverse sinus	http://purl.obolibrary.org/obo/UBERON_0017635	paired venous dural sinus		One of the dural venous sinuses and drains the superior sagittal sinus the occipital sinus and the straight sinus, and empties into the sigmoid sinus which in turn reaches the jugular bulb.
http://purl.obolibrary.org/obo/UBERON_0001651	right pulmonary artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The pulmonary artery that supplies the right lung.
http://purl.obolibrary.org/obo/UBERON_0001652	left pulmonary artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The pulmonary artery that supplies the left lung.
http://purl.obolibrary.org/obo/UBERON_0001653	facial vein	http://purl.obolibrary.org/obo/UBERON_0009141	craniocervical region vein		The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001663	cerebral vein	http://purl.obolibrary.org/obo/UBERON_0003499	brain blood vessel		The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001665	triceps surae	http://purl.obolibrary.org/obo/UBERON_0004256	hindlimb zeugopod muscle		The triceps surae is a pair of muscles located at the calf - the gastrocnemius and the soleus. These muscles both insert into the calcaneus, the bone of the heel of the human foot, and form the major part of the muscle of the back part of the lower leg, commonly known as the calf muscle. The triceps surae is connected to the foot through the Achilles tendon, and has 3 heads deriving from the 2 major masses of muscle. The superficial portion (the gastrocnemius) gives off 2 heads attaching to the base of the femur directly above the knee. The deep (profundis) mass of muscle (the soleus) forms the remaining head which attaches to the superior posterior area of the tibia. The triceps surae is innervated by the tibial nerve, specifically, nerve roots L5-S2. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001667	tibialis posterior	http://purl.obolibrary.org/obo/UBERON_0008230	tibialis		The Tibialis posterior is the most central of all the leg muscles, and is located in the posterior compartment of the leg. It is the key stabilizing muscle of the lower leg. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001668	cerebellar vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains the cerebellum.
http://purl.obolibrary.org/obo/UBERON_0001674	masseteric vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A plexiform vein accompanying the masseteric artery that empty into the pterygoid venous plexus.
http://purl.obolibrary.org/obo/UBERON_0001675	trigeminal ganglion	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.
http://purl.obolibrary.org/obo/UBERON_0001676	occipital bone	http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone		The bone at the lower, posterior part of the skull.
http://purl.obolibrary.org/obo/UBERON_0001678	temporal bone	http://purl.obolibrary.org/obo/UBERON_0008193	pneumatized bone		The large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous.
http://purl.obolibrary.org/obo/UBERON_0001680	lacrimal bone	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla.
http://purl.obolibrary.org/obo/UBERON_0001681	nasal bone	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		One of two small oblong bones, varying in size and form in different individuals; they are placed side by side at the middle and upper part of the face, and form, by their junction, 'the bridge' of the nose[WP]. Paired dermal bones, likened to a bone tube, positioned lateral to the supraethmoid. Nasal bones are transversed by the anterior most part of the supraorbital canals and bear one neuromast foramen in zebrafish[ZFA].
http://purl.obolibrary.org/obo/UBERON_0001682	palatine bone	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A paired dermal bone situated in the mid-palate that helps form the hard palate [Palaeos].
http://purl.obolibrary.org/obo/UBERON_0001683	jugal bone	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The quadrilateral bone that forms the prominence of the cheek.
http://purl.obolibrary.org/obo/UBERON_0001685	hyoid bone	http://purl.obolibrary.org/obo/UBERON_0008001	irregular bone		A horseshoe shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. The hyoid bone provides attachment to the muscles of the floor of the mouth and the tongue above, the larynx below, and the epiglottis and pharynx behind. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001686	auditory ossicle bone	http://purl.obolibrary.org/obo/UBERON_0003457	head bone		One of 3 small bones contained within the middle ear space and serve to transmit sounds from the air to the fluid-filled labyrinth. The absence of the auditory ossicles would constitute a moderate-to-severe hearing loss. The term 'ossicles' literally means 'tiny bones' and commonly refers to the auditory ossicles, though the term may refer to any small bone throughout the body. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001687	stapes bone	http://purl.obolibrary.org/obo/UBERON_0015016	stapes endochondral element		The stapes or stirrup is the stirrup-shaped small bone or ossicle in the middle ear which is attached to the incus laterally and to the fenestra ovalis, the 'oval window' medially. The oval window is adjacent to the vestibule of the inner ear. The stapes is the smallest and lightest bone in the human body. The stapes transmits the sound vibrations from the incus to the membrane of the inner ear inside the fenestra ovalis. The stapes is also stabilized by the stapedius muscle, which is innervated by the facial nerve. In non-mammalian vertebrates, the bone homologous to the stapes is usually called the columella; however, in reptiles, either term may be used[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001688	incus bone	http://purl.obolibrary.org/obo/UBERON_0015017	incus endochondral element		The incus or anvil is the anvil-shaped small bone or ossicle in the middle ear. It connects the malleus to the stapes. It was first described by Alessandro Achillin of Bologna. The incus transmits sound vibrations from the malleus to the stapes. The incus only exists in mammals, and is derived from a reptilian upper jaw bone, the quadrate bone. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001689	malleus bone	http://purl.obolibrary.org/obo/UBERON_0015018	malleus endochondral element		The malleus or hammer is a hammer-shaped small bone or ossicle of the middle ear which connects with the incus and is attached to the inner surface of the eardrum. The word is Latin for hammer. It transmits the sound vibrations from the eardrum to the incus. The malleus is unique to mammals, and evolved from a lower jaw bone in basal amniotes called the articular, which still forms part of the jaw joint in reptiles. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001690	ear	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.
http://purl.obolibrary.org/obo/UBERON_0001694	petrous part of temporal bone	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The petrous portion of the temporal bone or pyramid is pyramidal and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents for examination a base, an apex, three surfaces, and three angles, and contains, in its interior, the essential parts of the organ of hearing. The petrous portion is among the most basal elements of the skull and forms part of the endocranium.[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001695	squamous part of temporal bone	http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone		A bone which is fused with the temporal bone in many mammals and forms part of the cheek region articulating with quadrate and pterygoid in other vertebrates.
http://purl.obolibrary.org/obo/UBERON_0001697	orbit of skull	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball.
http://purl.obolibrary.org/obo/UBERON_0001700	geniculate ganglion	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve).
http://purl.obolibrary.org/obo/UBERON_0001701	glossopharyngeal ganglion	http://purl.obolibrary.org/obo/UBERON_0009127	epibranchial ganglion		The group of neuron cell bodies associated with the ninth cranial nerve.
http://purl.obolibrary.org/obo/UBERON_0001702	eyelash	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		Any of the hairs that grow at the edge of the upper or lower eyelid.
http://purl.obolibrary.org/obo/UBERON_0001703	neurocranium	http://purl.obolibrary.org/obo/UBERON_0011158	primary subdivision of skull		Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof.
http://purl.obolibrary.org/obo/UBERON_0001706	nasal septum	http://purl.obolibrary.org/obo/UBERON_0003037	septum		The nasal septum separates the left and right airways in the nose, dividing the two nostrils. It is depressed by the Depressor septi nasi muscle. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001709	upper jaw region	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].
http://purl.obolibrary.org/obo/UBERON_0001710	lower jaw region	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].
http://purl.obolibrary.org/obo/UBERON_0001714	cranial ganglion	http://purl.obolibrary.org/obo/UBERON_0000045	ganglion		The groups of nerve cell bodies associated with the twelve cranial nerves.
http://purl.obolibrary.org/obo/UBERON_0001715	oculomotor nuclear complex	http://purl.obolibrary.org/obo/UBERON_0019267	gray matter of midbrain		Nuclear complex containing subnuclei that give rise to the axons of the occulomotor nerve, both motor and parasympathetic fibers, situated at the midline at the level of the superior colliculus in the midbrain tegmentum (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533-534).
http://purl.obolibrary.org/obo/UBERON_0001716	secondary palate	http://purl.obolibrary.org/obo/UBERON_0007375	roof of mouth		The part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences.
http://purl.obolibrary.org/obo/UBERON_0001720	cochlear nucleus	http://purl.obolibrary.org/obo/UBERON_0007635	nucleus of medulla oblongata		Any of the nuclei of the cochlear nuclear complex.
http://purl.obolibrary.org/obo/UBERON_0001725	cranial synchondrosis	http://purl.obolibrary.org/obo/UBERON_0002215	synchondrosis		The cartilaginous joints of the skull; these include sphenoethmoidal synchondrosis, sphenooccipital synchondrosis, sphenopetrosal synchondrosis, petrooccipital synchondrosis, anterior intraoccipital synchondrosis and posterior intraoccipital synchondrosis.
http://purl.obolibrary.org/obo/UBERON_0001727	taste bud	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		A specialized receptor organ that is a collection of cells spanning the gustatory epithelium.
http://purl.obolibrary.org/obo/UBERON_0001731	cavity of pharynx	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a pharynx.
http://purl.obolibrary.org/obo/UBERON_0001738	thyroid cartilage	http://purl.obolibrary.org/obo/UBERON_0001739	laryngeal cartilage		The largest of the laryngeal cartilages.
http://purl.obolibrary.org/obo/UBERON_0001740	arytenoid cartilage	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The paired triangular laryngeal cartilages located postlaterally at the level of the thyroid cartilage.
http://purl.obolibrary.org/obo/UBERON_0001742	epiglottic cartilage	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		The most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing.
http://purl.obolibrary.org/obo/UBERON_0001743	ligament of larynx	http://purl.obolibrary.org/obo/UBERON_0008845	nonskeletal ligament		A ligament that is part of a larynx and connexts the cartilages of the larynx.
http://purl.obolibrary.org/obo/UBERON_0001744	lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0034769	lymphomyeloid tissue		Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP].
http://purl.obolibrary.org/obo/UBERON_0001745	secondary nodular lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0000444	lymphoid follicle		A lymphoid follicle that contains a germinal center.
http://purl.obolibrary.org/obo/UBERON_0001747	parenchyma of thyroid gland	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		A parenchyma that is part of a thyroid follicle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001748	capsule of parathyroid gland	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		The dense and irregular connective tissue capsule surrounding a parathyroid gland.
http://purl.obolibrary.org/obo/UBERON_0001749	parenchyma of parathyroid gland	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		A parenchyma that is part of a parathyroid gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001751	dentine	http://purl.obolibrary.org/obo/UBERON_4000013	mineralized skeletal tissue		Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular.
http://purl.obolibrary.org/obo/UBERON_0001752	enamel	http://purl.obolibrary.org/obo/UBERON_4000013	mineralized skeletal tissue		A dentine-like hypermineralized substance that covers the tooth tip. Enamel's primary mineral is hydroxylapatite, which is a crystalline calcium phosphate. Unlike dentin and bone, enamel does not contain collagen. Instead, it has two unique classes of proteins called amelogenins and enamelins[WP].
http://purl.obolibrary.org/obo/UBERON_0001753	cementum	http://purl.obolibrary.org/obo/UBERON_0010365	odontoid tissue		Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument.
http://purl.obolibrary.org/obo/UBERON_0001758	periodontium	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		The tissues that invest or help to invest and support the teeth, including the periodontal ligament, gingivae, cementum, and alveolar and supporting bone[BTO].
http://purl.obolibrary.org/obo/UBERON_0001763	odontogenic papilla	http://purl.obolibrary.org/obo/UBERON_0007213	mesenchyme derived from head neural crest		A condensation of odontoblasts that forms the part of a tooth germ that gives rise to dentin and pulp in the mature tooth. It lies below a cellular aggregation known as the enamel organ.
http://purl.obolibrary.org/obo/UBERON_0001765	mammary duct	http://purl.obolibrary.org/obo/UBERON_0003914	epithelial tube		Epithelial tube that transports milk[GO].
http://purl.obolibrary.org/obo/UBERON_0001766	anterior chamber of eyeball	http://purl.obolibrary.org/obo/UBERON_0006311	chamber of eyeball		The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens.
http://purl.obolibrary.org/obo/UBERON_0001772	corneal epithelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		The smooth stratified squamous epithelium that covers the outer surface of the cornea.
http://purl.obolibrary.org/obo/UBERON_0001773	sclera	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP].
http://purl.obolibrary.org/obo/UBERON_0001774	skeletal muscle of trunk	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		A skeletal muscle organ that is part of the trunk region.
http://purl.obolibrary.org/obo/UBERON_0001777	substantia propria of cornea	http://purl.obolibrary.org/obo/UBERON_0003891	stroma		The lamellated connective tissue of the cornea between the Bowman and Descemet membranes.
http://purl.obolibrary.org/obo/UBERON_0001778	ciliary epithelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		A double layer covering the ciliary body that produces aqueous humor.
http://purl.obolibrary.org/obo/UBERON_0001779	iris stroma	http://purl.obolibrary.org/obo/UBERON_0003891	stroma		The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae.
http://purl.obolibrary.org/obo/UBERON_0001780	spinal nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified].
http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina	http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer		Any of the layers that make up the retina[MP].
http://purl.obolibrary.org/obo/UBERON_0001782	pigmented layer of retina	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP].
http://purl.obolibrary.org/obo/UBERON_0001783	optic disc	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The optic disc or optic nerve head is the location where ganglion cell axons exit the eye to form the optic nerve. There are no light sensitive rods or cones to respond to a light stimulus at this point. This causes a break in the visual field called 'the blind spot' or the 'physiological blind spot'. The optic nerve head in a normal human eye carries from 1 to 1.2 million neurons from the eye towards the brain. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001786	fovea centralis	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A depression in the inner retinal surface within the macula lutea, the photoreceptor layer of which is entirely cones and which is specialized for maximum visual acuity.
http://purl.obolibrary.org/obo/UBERON_0001787	photoreceptor layer of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		The layer within the retina where the photoreceptor cell receptor segments reside.
http://purl.obolibrary.org/obo/UBERON_0001788	outer limiting layer of retina	http://purl.obolibrary.org/obo/UBERON_0007619	limiting membrane of retina		The row of jucntional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier[MP].
http://purl.obolibrary.org/obo/UBERON_0001789	outer nuclear layer of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		The layer within the retina where the photoreceptor cell bodies reside.
http://purl.obolibrary.org/obo/UBERON_0001790	outer plexiform layer of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		The layer within the retina where the bipolar cells synapse with the photoreceptor cells[ZFA]. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells[GO].
http://purl.obolibrary.org/obo/UBERON_0001791	inner nuclear layer of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia).
http://purl.obolibrary.org/obo/UBERON_0001792	ganglionic layer of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		Cytoarchitectural layer of retina that contains somata of retinal ganglion cells, bounded by the stratum opticum and the inner plexiform layer.
http://purl.obolibrary.org/obo/UBERON_0001793	nerve fiber layer of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		Layer of the retina formed by expansion of the fibers of the optic nerve.
http://purl.obolibrary.org/obo/UBERON_0001794	inner limiting layer of retina	http://purl.obolibrary.org/obo/UBERON_0007619	limiting membrane of retina		The row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous[MP].
http://purl.obolibrary.org/obo/UBERON_0001795	inner plexiform layer of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		Cytoarchitectural layer of the retina that is made up of a dense reticulum of fibrils formed by interlaced dendrites of retinal ganglion cells and cells of the inner nuclear layer (adapted from Wikipedia).
http://purl.obolibrary.org/obo/UBERON_0001796	aqueous humor of eyeball	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		A thick watery refractive medium that fills the space between the lens and the cornea[WP].
http://purl.obolibrary.org/obo/UBERON_0001798	vitreous body	http://purl.obolibrary.org/obo/UBERON_0011825	loose connective tissue		Gelatinous mucoid tissue that is composed of vitreous humor and fills the cavity behind the crystalline lens of the eye and in front of the retina[MP,modified].
http://purl.obolibrary.org/obo/UBERON_0001799	vitreous chamber of eyeball	http://purl.obolibrary.org/obo/UBERON_0006311	chamber of eyeball		The chamber in the eyeball enclosing the vitreous humor, bounded anteriorly by the lens and ciliary body and posteriorly by the posterior wall of the eyeball[BTO,modified].
http://purl.obolibrary.org/obo/UBERON_0001800	sensory ganglion	http://purl.obolibrary.org/obo/UBERON_0000045	ganglion		The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.
http://purl.obolibrary.org/obo/UBERON_0001801	anterior segment of eyeball	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive).
http://purl.obolibrary.org/obo/UBERON_0001802	posterior segment of eyeball	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive).
http://purl.obolibrary.org/obo/UBERON_0001803	epithelium of lens	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		A layer of epithelial cells that is part of the eye.
http://purl.obolibrary.org/obo/UBERON_0001804	capsule of lens	http://purl.obolibrary.org/obo/UBERON_0005764	acellular membrane		The elastic, clear, membrane-like structure, that is outer most layer of the lens.
http://purl.obolibrary.org/obo/UBERON_0001805	autonomic ganglion	http://purl.obolibrary.org/obo/UBERON_0003338	ganglion of peripheral nervous system		Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.
http://purl.obolibrary.org/obo/UBERON_0001806	sympathetic ganglion	http://purl.obolibrary.org/obo/UBERON_0001805	autonomic ganglion		A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
http://purl.obolibrary.org/obo/UBERON_0001808	parasympathetic ganglion	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		Ganglion containing neurons that receive innervation from parasympathetic neurons in the central nervous system and subserves parasympathetic functions through innervation of smooth muscle, cardiac muscle and glands.
http://purl.obolibrary.org/obo/UBERON_0001810	nerve plexus	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA].
http://purl.obolibrary.org/obo/UBERON_0001812	palpebral conjunctiva	http://purl.obolibrary.org/obo/UBERON_0010305	subdivision of conjunctiva		A thin transparent mucous membrane that covers the posterior surface of the eyelids and is continuous with the bulbar conjunctiva at the conjunctival fornicies.
http://purl.obolibrary.org/obo/UBERON_0001813	spinal nerve plexus	http://purl.obolibrary.org/obo/UBERON_0001810	nerve plexus		An intermingling of fiber fascicles from adjacent spinal nerves to form a network.
http://purl.obolibrary.org/obo/UBERON_0001815	lumbosacral nerve plexus	http://purl.obolibrary.org/obo/UBERON_0001813	spinal nerve plexus		An arrangement of nerve fibers, running from the spine that travels to the pelvic appendage where it innervates skin and muscle.
http://purl.obolibrary.org/obo/UBERON_0001816	autonomic nerve plexus	http://purl.obolibrary.org/obo/UBERON_0001810	nerve plexus		A nerve plexus that is part of an autonomic nervous system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001818	tarsal gland	http://purl.obolibrary.org/obo/UBERON_0015251	modified sebaceous gland		A modified lobulated sebaceous gland at the rim of an eyelid, responsible for the supply of meibum.
http://purl.obolibrary.org/obo/UBERON_0001819	palpebral fissure	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		Orifice separating upper and lower eyelids. In the human adult this measures about 10mm vertically and 30 mm horizontally. It can be reduced in size in fetal alcohol syndrome. In Trisomy 9 the palpebral fissures can be upslanting. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001823	nasal cartilage	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		One of the cartilage structures in the nose that provide form and support[WP].
http://purl.obolibrary.org/obo/UBERON_0001824	mucosa of larynx	http://purl.obolibrary.org/obo/UBERON_0004785	respiratory system mucosa		The mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx.
http://purl.obolibrary.org/obo/UBERON_0001826	nasal cavity mucosa	http://purl.obolibrary.org/obo/UBERON_0004785	respiratory system mucosa		The mucous membrane that lines the nasal cavity[MP].
http://purl.obolibrary.org/obo/UBERON_0001827	secretion of lacrimal gland	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		Aqueous substance secreted by the lacrimal gland.
http://purl.obolibrary.org/obo/UBERON_0001829	major salivary gland	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		One of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands.
http://purl.obolibrary.org/obo/UBERON_0001836	saliva	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions.
http://purl.obolibrary.org/obo/UBERON_0001837	duct of salivary gland	http://purl.obolibrary.org/obo/UBERON_0003928	digestive system duct		The duct of a salivary gland.
http://purl.obolibrary.org/obo/UBERON_0001838	sublingual duct	http://purl.obolibrary.org/obo/UBERON_0001837	duct of salivary gland		A duct of a sublingual gland.
http://purl.obolibrary.org/obo/UBERON_0001839	bony labyrinth	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		A system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0001840	semicircular canal	http://purl.obolibrary.org/obo/UBERON_0000025	tube		One of three half-circular, interconnected tubes located inside each ear[WP].
http://purl.obolibrary.org/obo/UBERON_0001844	cochlea	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		The spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001847	lobule of pinna	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		The soft lower part of the external ear, projecting below the antitragus.
http://purl.obolibrary.org/obo/UBERON_0001848	auricular cartilage	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		Cartilage of the pinna and much of the external ear canal.
http://purl.obolibrary.org/obo/UBERON_0001849	membranous labyrinth	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP].
http://purl.obolibrary.org/obo/UBERON_0001850	lacrimal drainage system	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A collection of channels that connects the conjunctival sac with the nasal cavity, encompassing the lacrimal ducts, the lacrimal sac and the naso-lacrimal duct.
http://purl.obolibrary.org/obo/UBERON_0001851	cortex	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Outermost layer of an organ[WP].
http://purl.obolibrary.org/obo/UBERON_0001855	cochlear duct of membranous labyrinth	http://purl.obolibrary.org/obo/UBERON_0000025	tube		An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP].
http://purl.obolibrary.org/obo/UBERON_0001862	vestibular labyrinth	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The part of the membranous labyrinth that includes the utricle and saccule lodged within the vestibule and the semicircular ducts lodged eccentrically in the corresponding canals.
http://purl.obolibrary.org/obo/UBERON_0001866	sebum	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		Fatty lubricant matter secreted by sebaceous glands, and made of made of triglyceride oils, wax, squalene, and metabolytes of fat-producing cells[BTO,WP].
http://purl.obolibrary.org/obo/UBERON_0001867	cartilage of external ear	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		A cartilage that is part of a external ear [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001868	skin of chest	http://purl.obolibrary.org/obo/UBERON_0001418	skin of thorax		A zone of skin that is part of a chest [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001870	frontal cortex	http://purl.obolibrary.org/obo/UBERON_0016529	cortex of cerebral lobe		Anterior portion of the neocortex, lying anterior to the central sulcus in humans. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally[NIFSTD,modified].
http://purl.obolibrary.org/obo/UBERON_0001873	caudate nucleus	http://purl.obolibrary.org/obo/UBERON_0009663	telencephalic nucleus		Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species.
http://purl.obolibrary.org/obo/UBERON_0001874	putamen	http://purl.obolibrary.org/obo/UBERON_0009663	telencephalic nucleus		Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion.
http://purl.obolibrary.org/obo/UBERON_0001875	globus pallidus	http://purl.obolibrary.org/obo/UBERON_0009663	telencephalic nucleus		Subcortical nucleus, functionally part of the basal ganglia, which consists of two segments the external (or lateral) and internal (or medial) separated by the medial medullary lamina in primates. In rodents, The globus pallidus lateral is separated from the medial segment by the fibers of the internal capsule/cerebral peduncle.
http://purl.obolibrary.org/obo/UBERON_0001884	phrenic nerve	http://purl.obolibrary.org/obo/UBERON_0003443	thoracic cavity nerve		A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium.
http://purl.obolibrary.org/obo/UBERON_0001887	internal capsule of telencephalon	http://purl.obolibrary.org/obo/UBERON_0002437	cerebral hemisphere white matter		White matter regional part of brain which is flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem and spinal cord. It consists of three distinct parts: an anterior limb, posterior limb, and genu. (Adapted from MSH by Maryann Martone).
http://purl.obolibrary.org/obo/UBERON_0001890	forebrain	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The most anterior region of the brain including both the telencephalon and diencephalon.
http://purl.obolibrary.org/obo/UBERON_0001891	midbrain	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].
http://purl.obolibrary.org/obo/UBERON_0001892	rhombomere	http://purl.obolibrary.org/obo/UBERON_0004731	neuromere		A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP].
http://purl.obolibrary.org/obo/UBERON_0001895	metencephalon	http://purl.obolibrary.org/obo/UBERON_0004733	segmental subdivision of hindbrain		Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0001896	medulla oblongata	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO].
http://purl.obolibrary.org/obo/UBERON_0001897	dorsal plus ventral thalamus	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87).
http://purl.obolibrary.org/obo/UBERON_0001898	hypothalamus	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia].
http://purl.obolibrary.org/obo/UBERON_0001899	epithalamus	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Most dorsal part of the thalamus, comprising the pineal gland and habenular nuclei in most vertebrates. In a few vertebrates, it also includes the parietal eye. (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed, 2005, pg. 345-346.
http://purl.obolibrary.org/obo/UBERON_0001901	epithelium of trachea	http://purl.obolibrary.org/obo/UBERON_0008397	tracheobronchial epithelium		The epithelial lining of the trachea which contains numerous ciliated cells.
http://purl.obolibrary.org/obo/UBERON_0001902	epithelium of small intestine	http://purl.obolibrary.org/obo/UBERON_0001277	intestinal epithelium		An epithelium that is part of a small intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001911	mammary gland	http://purl.obolibrary.org/obo/UBERON_0019319	exocrine gland of integumental system		A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males.
http://purl.obolibrary.org/obo/UBERON_0001912	lobule of mammary gland	http://purl.obolibrary.org/obo/UBERON_0009911	lobule		Organ component of the mammary gland which consists of an aggregate of mammary alveoli that communicate with a lobular lactiferous duct.[FMA].
http://purl.obolibrary.org/obo/UBERON_0001913	milk	http://purl.obolibrary.org/obo/UBERON_0006539	mammary gland fluid/secretion		An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation.
http://purl.obolibrary.org/obo/UBERON_0001915	endothelium of capillary	http://purl.obolibrary.org/obo/UBERON_0008339	microvascular endothelium		An endothelium that is part of a capillary [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001916	endothelium of arteriole	http://purl.obolibrary.org/obo/UBERON_0008339	microvascular endothelium		An endothelium that is part of an arteriole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001917	endothelium of artery	http://purl.obolibrary.org/obo/UBERON_0004700	arterial system endothelium		An endothelium that is part of an artery [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001918	endothelium of venule	http://purl.obolibrary.org/obo/UBERON_0008339	microvascular endothelium		An endothelium that is part of a venule [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001919	endothelium of vein	http://purl.obolibrary.org/obo/UBERON_0004701	venous system endothelium		An endothelium that is part of a vein [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001943	midbrain tegmentum	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].
http://purl.obolibrary.org/obo/UBERON_0001948	regional part of spinal cord	http://purl.obolibrary.org/obo/UBERON_0000073	regional part of nervous system		A multi-tissue structure that is part of a spinal cord.
http://purl.obolibrary.org/obo/UBERON_0001949	gingival epithelium	http://purl.obolibrary.org/obo/UBERON_0035037	jaw epithelium		A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO].
http://purl.obolibrary.org/obo/UBERON_0001950	neocortex	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN).
http://purl.obolibrary.org/obo/UBERON_0001951	epithelium of nasopharynx	http://purl.obolibrary.org/obo/UBERON_0004814	upper respiratory tract epithelium		An epithelium that is part of a nasopharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001954	Ammon's horn	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum.
http://purl.obolibrary.org/obo/UBERON_0001955	epithelium of respiratory bronchiole	http://purl.obolibrary.org/obo/UBERON_0002051	epithelium of bronchiole		An epithelium that is part of a respiratory bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001956	cartilage of bronchus	http://purl.obolibrary.org/obo/UBERON_0003603	lower respiratory tract cartilage		The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP].
http://purl.obolibrary.org/obo/UBERON_0001957	submucosa of bronchus	http://purl.obolibrary.org/obo/UBERON_0004777	respiratory system submucosa		A submucosa that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001958	terminal bronchiole epithelium	http://purl.obolibrary.org/obo/UBERON_0002051	epithelium of bronchiole		An epithelium that lines a terminal bronchiole.
http://purl.obolibrary.org/obo/UBERON_0001959	white pulp of spleen	http://purl.obolibrary.org/obo/UBERON_1000023	spleen pulp		The parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies.
http://purl.obolibrary.org/obo/UBERON_0001962	gut-associated lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0001961	mucosa-associated lymphoid tissue		Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO].
http://purl.obolibrary.org/obo/UBERON_0001963	bronchial-associated lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0001961	mucosa-associated lymphoid tissue		A diffuse collection of lymphpoid cells that participate in airway immune responses.
http://purl.obolibrary.org/obo/UBERON_0001968	semen	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		Organism substance that is composed of sperm cells suspended in seminal fluid.
http://purl.obolibrary.org/obo/UBERON_0001969	blood plasma	http://purl.obolibrary.org/obo/UBERON_0000179	haemolymphatic fluid		The liquid component of blood, in which erythrocytes are suspended.
http://purl.obolibrary.org/obo/UBERON_0001970	bile	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium.
http://purl.obolibrary.org/obo/UBERON_0001972	submucosa of esophagus	http://purl.obolibrary.org/obo/UBERON_0018257	submucosa of digestive tract		A submucosa that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001974	lamina propria of esophagus	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001975	serosa of esophagus	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		A serous membrane that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001976	epithelium of esophagus	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		The epithelial layer that lines the luminal space of the esophagus.
http://purl.obolibrary.org/obo/UBERON_0001977	blood serum	http://purl.obolibrary.org/obo/UBERON_0000179	haemolymphatic fluid		The portion of blood plasma that excludes clotting factors.
http://purl.obolibrary.org/obo/UBERON_0001979	venule	http://purl.obolibrary.org/obo/UBERON_8410081	blood microvessel		One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins.
http://purl.obolibrary.org/obo/UBERON_0001980	arteriole	http://purl.obolibrary.org/obo/UBERON_8410081	blood microvessel		The smallest division of the artery located between the muscular arteries and the capillaries[GO].
http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel	http://purl.obolibrary.org/obo/UBERON_0000055	vessel		A vessel through which blood circulates in the body.
http://purl.obolibrary.org/obo/UBERON_0001983	crypt of Lieberkuhn	http://purl.obolibrary.org/obo/UBERON_0000333	intestinal gland		The tubular intestinal glands found in the mucosal membranes.
http://purl.obolibrary.org/obo/UBERON_0001984	crypt of Lieberkuhn of large intestine	http://purl.obolibrary.org/obo/UBERON_0001983	crypt of Lieberkuhn		A crypt of Lieberkühn that is part of a large intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0001985	corneal endothelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP].
http://purl.obolibrary.org/obo/UBERON_0001986	endothelium	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].
http://purl.obolibrary.org/obo/UBERON_0001988	feces	http://purl.obolibrary.org/obo/UBERON_0000174	excreta		Portion of semisolid bodily waste discharged through the anus[MW,modified].
http://purl.obolibrary.org/obo/UBERON_0001994	hyaline cartilage tissue	http://purl.obolibrary.org/obo/UBERON_0002418	cartilage tissue		Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.
http://purl.obolibrary.org/obo/UBERON_0001995	fibrocartilage	http://purl.obolibrary.org/obo/UBERON_0002418	cartilage tissue		Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns.
http://purl.obolibrary.org/obo/UBERON_0001996	elastic cartilage tissue	http://purl.obolibrary.org/obo/UBERON_0011589	non-mineralized cartilage tissue		Cartilage tissue that is flexible and contains abundant elastic fibers.
http://purl.obolibrary.org/obo/UBERON_0002000	gluteal muscle	http://purl.obolibrary.org/obo/UBERON_0001497	muscle of pelvic girdle		On of the muscles that make up the buttocks: the gluteus maximus muscle, gluteus medius muscle and gluteus minimus muscle.
http://purl.obolibrary.org/obo/UBERON_0002001	joint of rib	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		Any joint that connects a rib to another structure (or another rib). Examples: costochondral, costovertebral, interchondral, sternocostal joints.
http://purl.obolibrary.org/obo/UBERON_0002005	enteric nervous system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation[GO].
http://purl.obolibrary.org/obo/UBERON_0002006	cortex of lymph node	http://purl.obolibrary.org/obo/UBERON_0001851	cortex		Peripheral portion of the lymph node, underneath the capsule[WP].
http://purl.obolibrary.org/obo/UBERON_0002007	medulla of lymph node	http://purl.obolibrary.org/obo/UBERON_0000958	medulla of organ		The medullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells.
http://purl.obolibrary.org/obo/UBERON_0002008	cardiac nerve plexus	http://purl.obolibrary.org/obo/UBERON_0001816	autonomic nerve plexus		A plexus of nerves situated at the base of the heart that innervate the heart.
http://purl.obolibrary.org/obo/UBERON_0002011	thoracodorsal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The thoracodorsal artery is a branch of the subscapular artery. It travels inferiorly with the thoracodorsal nerve and supplies the latissimus dorsi. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002015	kidney capsule	http://purl.obolibrary.org/obo/UBERON_0011824	fibrous connective tissue		The tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage.
http://purl.obolibrary.org/obo/UBERON_0002017	portal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO].
http://purl.obolibrary.org/obo/UBERON_0002020	gray matter	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.
http://purl.obolibrary.org/obo/UBERON_0002025	stratum basale of epidermis	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells.
http://purl.obolibrary.org/obo/UBERON_0002026	stratum spinosum of epidermis	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance.
http://purl.obolibrary.org/obo/UBERON_0002027	stratum corneum of epidermis	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		The outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells.
http://purl.obolibrary.org/obo/UBERON_0002028	hindbrain	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].
http://purl.obolibrary.org/obo/UBERON_0002029	epithelium of gall bladder	http://purl.obolibrary.org/obo/UBERON_0034932	epithelium of biliary system		The simple columnar epithelial lining of the gall bladder.
http://purl.obolibrary.org/obo/UBERON_0002031	epithelium of bronchus	http://purl.obolibrary.org/obo/UBERON_0008397	tracheobronchial epithelium		An epithelium that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002032	areola	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle and modified sebaceous glands and which surrounds the nipple.
http://purl.obolibrary.org/obo/UBERON_0002033	arrector muscle of hair	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A tiny smooth muscle that connects the hair follicle with the dermis.
http://purl.obolibrary.org/obo/UBERON_0002036	striated muscle tissue	http://purl.obolibrary.org/obo/UBERON_0002385	muscle tissue		Muscle tissue that contains fibers that are divided by transverse bands into striations.
http://purl.obolibrary.org/obo/UBERON_0002038	substantia nigra	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM).
http://purl.obolibrary.org/obo/UBERON_0002040	bronchial artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		A systemic artery that supplies the lung with with oxygenated blood.
http://purl.obolibrary.org/obo/UBERON_0002042	lymphatic vessel endothelium	http://purl.obolibrary.org/obo/UBERON_0004852	cardiovascular system endothelium		An endothelium that is part of a lymphatic vessel [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002047	pontine raphe nucleus	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002049	vasculature	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.
http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		Anatomical structure that is part of an embryo.
http://purl.obolibrary.org/obo/UBERON_0002051	epithelium of bronchiole	http://purl.obolibrary.org/obo/UBERON_0008397	tracheobronchial epithelium		An epithelium that is part of a bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002052	adrenal gland capsule	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		The thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex.
http://purl.obolibrary.org/obo/UBERON_0002056	inferior suprarenal artery	http://purl.obolibrary.org/obo/UBERON_0005624	suprarenal artery		Each renal artery gives off some small inferior suprarenal branches to the suprarenal gland, the ureter, and the surrounding cellular tissue and muscles. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002057	phrenic artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		An artery that supplies the diaphragm.
http://purl.obolibrary.org/obo/UBERON_0002058	main ciliary ganglion	http://purl.obolibrary.org/obo/UBERON_0001714	cranial ganglion		A parasympathetic ganglion located in the posterior orbit that contains preganglionic nerves and postganglionic neurons of the oculomotor nerve, connects to the Edinger-Westphal nucleus via the oculomotor nerve and the eye muscles via the short ciliary nerve.
http://purl.obolibrary.org/obo/UBERON_0002059	submandibular ganglion	http://purl.obolibrary.org/obo/UBERON_0001808	parasympathetic ganglion		The ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands.
http://purl.obolibrary.org/obo/UBERON_0002060	femoral artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The femoral artery is a large artery in the muscles of the thigh. It is a continuation of external iliac artery where it enters the femoral triangle at the mid inguinal point behind the inguinal ligament. It leaves femoral triangle through apex beneath the sartorius muscle. It enters the popliteal fossa by passing through the 5th osseo-aponeurotic(adductor hiatus) opening of adductor magnus where it becomes the Popliteal Artery. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002061	truncus arteriosus	http://purl.obolibrary.org/obo/UBERON_0003498	heart blood vessel		The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles.
http://purl.obolibrary.org/obo/UBERON_0002062	endocardial cushion	http://purl.obolibrary.org/obo/UBERON_0014387	mesenchyme derived from neural crest		The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].
http://purl.obolibrary.org/obo/UBERON_0002063	sinus venosus	http://purl.obolibrary.org/obo/UBERON_0004151	cardiac chamber		The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart.
http://purl.obolibrary.org/obo/UBERON_0002065	posterior cardinal vein	http://purl.obolibrary.org/obo/UBERON_0004344	cardinal vein		One of two paired cardinal veins that return blood from the body of the embryo[Kardong].
http://purl.obolibrary.org/obo/UBERON_0002069	stratum granulosum of epidermis	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		The layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis.
http://purl.obolibrary.org/obo/UBERON_0002072	hypodermis	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].
http://purl.obolibrary.org/obo/UBERON_0002073	hair follicle	http://purl.obolibrary.org/obo/UBERON_0036150	skin appendage follicle		A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO].
http://purl.obolibrary.org/obo/UBERON_0002074	hair shaft	http://purl.obolibrary.org/obo/UBERON_0000021	cutaneous appendage		The main part of the hair which is composed of trichocytes and is divided into the cortex and medulla.
http://purl.obolibrary.org/obo/UBERON_0002075	viscus	http://purl.obolibrary.org/obo/UBERON_0005177	trunk region element		An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.
http://purl.obolibrary.org/obo/UBERON_0002076	cuticle of hair	http://purl.obolibrary.org/obo/UBERON_0000119	cell layer		Smooth and glossy outer protective cell layer of hair shaft.
http://purl.obolibrary.org/obo/UBERON_0002077	cortex of hair	http://purl.obolibrary.org/obo/UBERON_0001851	cortex		A cortex that is part of a hair [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002078	right cardiac atrium	http://purl.obolibrary.org/obo/UBERON_0035554	right cardiac chamber		A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve.
http://purl.obolibrary.org/obo/UBERON_0002079	left cardiac atrium	http://purl.obolibrary.org/obo/UBERON_0035553	left cardiac chamber		A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve.
http://purl.obolibrary.org/obo/UBERON_0002080	heart right ventricle	http://purl.obolibrary.org/obo/UBERON_0035554	right cardiac chamber		A cardiac ventricle that is in the right side of the heart.
http://purl.obolibrary.org/obo/UBERON_0002081	cardiac atrium	http://purl.obolibrary.org/obo/UBERON_0004151	cardiac chamber		Cardiac chamber in which blood enters the heart.
http://purl.obolibrary.org/obo/UBERON_0002082	cardiac ventricle	http://purl.obolibrary.org/obo/UBERON_0004151	cardiac chamber		Cardiac chamber through which blood leaves the heart.
http://purl.obolibrary.org/obo/UBERON_0002084	heart left ventricle	http://purl.obolibrary.org/obo/UBERON_0035553	left cardiac chamber		A cardiac ventricle that is in the left side of the heart.
http://purl.obolibrary.org/obo/UBERON_0002085	interatrial septum	http://purl.obolibrary.org/obo/UBERON_0002099	cardiac septum		A cardiac septum that divides the left and right atria of the heart.
http://purl.obolibrary.org/obo/UBERON_0002087	atrioventricular canal	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The part of the heart connecting the atrium to the cardiac ventricle[ZFA]. In the developing heart, the constriction between the atrium and ventricle constitutes the atrial canal, and indicates the site of the future atrioventricular valves[WP].
http://purl.obolibrary.org/obo/UBERON_0002089	thoracodorsal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		Companion vein of the thoracodorsal artery, draining the apical part of the latissimus dorsi and merging with the circumflex scapular vein to form a subscapular vein.
http://purl.obolibrary.org/obo/UBERON_0002090	postcranial axial skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA].
http://purl.obolibrary.org/obo/UBERON_0002091	appendicular skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm].
http://purl.obolibrary.org/obo/UBERON_0002092	brain dura mater	http://purl.obolibrary.org/obo/UBERON_0003547	brain meninx		The fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer.
http://purl.obolibrary.org/obo/UBERON_0002093	spinal dura mater	http://purl.obolibrary.org/obo/UBERON_0002363	dura mater		A dura mater that is part of a spinal cord [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002094	interventricular septum	http://purl.obolibrary.org/obo/UBERON_0002099	cardiac septum		Cardiac septum which separates the right ventricle from the left ventricle.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002095	mesentery	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon.
http://purl.obolibrary.org/obo/UBERON_0002097	skin of body	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		The organ covering the body that consists of the dermis and epidermis.
http://purl.obolibrary.org/obo/UBERON_0002099	cardiac septum	http://purl.obolibrary.org/obo/UBERON_0003037	septum		The thin membranous structure between parts of the heart, including the atria, ventricles, and outflow tract.
http://purl.obolibrary.org/obo/UBERON_0002100	trunk	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.
http://purl.obolibrary.org/obo/UBERON_0002102	forelimb	http://purl.obolibrary.org/obo/UBERON_0004710	pectoral appendage		A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts.
http://purl.obolibrary.org/obo/UBERON_0002103	hindlimb	http://purl.obolibrary.org/obo/UBERON_0004709	pelvic appendage		A (free) limb that is connected to a pelvic girdle region. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pelvic girdle and its parts.
http://purl.obolibrary.org/obo/UBERON_0002104	visual system	http://purl.obolibrary.org/obo/UBERON_0001032	sensory system		The sensory system subserving the sense of vision.
http://purl.obolibrary.org/obo/UBERON_0002105	vestibulo-auditory system	http://purl.obolibrary.org/obo/UBERON_0001032	sensory system		Sensory system responsible for the perception of spatial orientation and auditory stimuli.
http://purl.obolibrary.org/obo/UBERON_0002109	pair of nares	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		Pair of nostrils.
http://purl.obolibrary.org/obo/UBERON_0002111	artery smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004695	arterial system smooth muscle		A portion of smooth muscle tissue that is part of an artery [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002112	smooth muscle of esophagus	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002118	right ovary	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An ovary that is part of a right side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002119	left ovary	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An ovary that is part of a left side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002120	pronephros	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO].
http://purl.obolibrary.org/obo/UBERON_0002122	capsule of thymus	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		The fibrous connective tissue surrounding the thymus.
http://purl.obolibrary.org/obo/UBERON_0002123	cortex of thymus	http://purl.obolibrary.org/obo/UBERON_0001851	cortex		The outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes.
http://purl.obolibrary.org/obo/UBERON_0002124	medulla of thymus	http://purl.obolibrary.org/obo/UBERON_0000958	medulla of organ		Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size.
http://purl.obolibrary.org/obo/UBERON_0002125	thymus lobule	http://purl.obolibrary.org/obo/UBERON_0009911	lobule		A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0002128	superior olivary complex	http://purl.obolibrary.org/obo/UBERON_0019263	gray matter of hindbrain		A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.
http://purl.obolibrary.org/obo/UBERON_0002129	cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0019263	gray matter of hindbrain		The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer.
http://purl.obolibrary.org/obo/UBERON_0002130	cerebellar nuclear complex	http://purl.obolibrary.org/obo/UBERON_0019263	gray matter of hindbrain		The gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei[MP].
http://purl.obolibrary.org/obo/UBERON_0002132	dentate nucleus	http://purl.obolibrary.org/obo/UBERON_0008995	nucleus of cerebellar nuclear complex		The largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers.
http://purl.obolibrary.org/obo/UBERON_0002133	atrioventricular valve	http://purl.obolibrary.org/obo/UBERON_0000946	cardiac valve		A cardial valve in the atrioventricular region that separates the atrium from the ventricle and prevent backflow from the ventricles into the atria during systole.
http://purl.obolibrary.org/obo/UBERON_0002148	locus ceruleus	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].
http://purl.obolibrary.org/obo/UBERON_0002149	superior salivatory nucleus	http://purl.obolibrary.org/obo/UBERON_0007635	nucleus of medulla oblongata		Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703).
http://purl.obolibrary.org/obo/UBERON_0002150	superior cerebellar peduncle	http://purl.obolibrary.org/obo/UBERON_0007416	cerebellar peduncle		A composite structure of the brain stem, which in NeuroNames is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM).
http://purl.obolibrary.org/obo/UBERON_0002152	middle cerebellar peduncle	http://purl.obolibrary.org/obo/UBERON_0019292	white matter of pons		Regional part of medullary white matter (according to Neuronames) primarily found at the level of the pons, consisting of a very large bundle of fibers originating in the pontine nuclei projecting to the cerebellum (MM).
http://purl.obolibrary.org/obo/UBERON_0002166	endocardium of atrium	http://purl.obolibrary.org/obo/UBERON_0002165	endocardium		Endocardium that is part of the atrium.
http://purl.obolibrary.org/obo/UBERON_0002167	right lung	http://purl.obolibrary.org/obo/UBERON_0002048	lung		Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002168	left lung	http://purl.obolibrary.org/obo/UBERON_0002048	lung		Lung which consists of the left upper lobe and left lower lobe.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002169	alveolar sac	http://purl.obolibrary.org/obo/UBERON_0007499	epithelial sac		The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters.
http://purl.obolibrary.org/obo/UBERON_0002173	pulmonary alveolar duct	http://purl.obolibrary.org/obo/UBERON_0000117	respiratory tube		The respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli.
http://purl.obolibrary.org/obo/UBERON_0002180	ventral funiculus of spinal cord	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The white substance of the spinal cord lying on either side between the ventral median fissure and the ventral roots of the spinal nerves.
http://purl.obolibrary.org/obo/UBERON_0002186	bronchiole	http://purl.obolibrary.org/obo/UBERON_0000117	respiratory tube		The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching.
http://purl.obolibrary.org/obo/UBERON_0002187	terminal bronchiole	http://purl.obolibrary.org/obo/UBERON_0002186	bronchiole		A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls.
http://purl.obolibrary.org/obo/UBERON_0002188	respiratory bronchiole	http://purl.obolibrary.org/obo/UBERON_0002186	bronchiole		A bronchiole that is the first segment of the respiratory zone.
http://purl.obolibrary.org/obo/UBERON_0002190	subcutaneous adipose tissue	http://purl.obolibrary.org/obo/UBERON_0001013	adipose tissue		A portion of adipose tissue that is part of the hypodermis, beneath the dermis.
http://purl.obolibrary.org/obo/UBERON_0002193	hemolymphoid system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.
http://purl.obolibrary.org/obo/UBERON_0002194	capsule of lymph node	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers.
http://purl.obolibrary.org/obo/UBERON_0002195	trabecula of lymph node	http://purl.obolibrary.org/obo/UBERON_0000440	trabecula		Membranous process coming from capsule of lymph node[WP].
http://purl.obolibrary.org/obo/UBERON_0002196	adenohypophysis	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA].
http://purl.obolibrary.org/obo/UBERON_0002199	integument	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The dermis, epidermis and hypodermis.
http://purl.obolibrary.org/obo/UBERON_0002200	vasculature of head	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		Vasculature that is part of a head [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002201	vasculature of trunk	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vasculature that is part of a trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002202	submucosa of trachea	http://purl.obolibrary.org/obo/UBERON_0004777	respiratory system submucosa		A submucosa that is part of a trachea.
http://purl.obolibrary.org/obo/UBERON_0002203	vasculature of eye	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		Vasculature that is part of the eye region.
http://purl.obolibrary.org/obo/UBERON_0002207	xiphoid process	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		A cartilaginous extension to the distal part of the sternum.
http://purl.obolibrary.org/obo/UBERON_0002208	sternebra	http://purl.obolibrary.org/obo/UBERON_0003827	thoracic segment bone		One of the bony segments of the sternum[TFD].
http://purl.obolibrary.org/obo/UBERON_0002209	fibrous joint	http://purl.obolibrary.org/obo/UBERON_0011134	nonsynovial joint		Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002210	syndesmosis	http://purl.obolibrary.org/obo/UBERON_0002213	cartilaginous joint		Fibrous joint in which the articulating bones or cartilages of the vertebral column and the limbs as well as articulating ossicles, are connected by skeletal ligaments or membranes. Examples: Intervertebral syndesmosis, inferior tibiofibular joint.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002213	cartilaginous joint	http://purl.obolibrary.org/obo/UBERON_0011134	nonsynovial joint		Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002215	synchondrosis	http://purl.obolibrary.org/obo/UBERON_0002213	cartilaginous joint		Cartilaginous joint in which the articulating bones or cartilages are connected by hyaline cartilage. Examples: spheno-occipital synchondrosis, first sternocostal joint.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002216	symphysis	http://purl.obolibrary.org/obo/UBERON_0002213	cartilaginous joint		Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002217	synovial joint	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002221	fontanelle	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP].
http://purl.obolibrary.org/obo/UBERON_0002224	thoracic cavity	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.
http://purl.obolibrary.org/obo/UBERON_0002228	rib	http://purl.obolibrary.org/obo/UBERON_0015019	rib endochondral element		An intersegmental rod-shaped bone that forms in the peritoneal membrane and attach to the vertebral parapophyses.
http://purl.obolibrary.org/obo/UBERON_0002234	proximal phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx		A proximal phalanx that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002235	tubercle of rib	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		The tubercle of a rib is an eminence on the posterior surface, at the junction of the neck and body of the rib, and nearer the lower than the upper border. It consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrae to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs[WP].
http://purl.obolibrary.org/obo/UBERON_0002236	costal cartilage	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		The nonvascular, resilient, flexible hyaline connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the with the lower border of the costal cartilage above it.
http://purl.obolibrary.org/obo/UBERON_0002237	true rib	http://purl.obolibrary.org/obo/UBERON_0002228	rib		A rib that is ventrally connected to the sternum.
http://purl.obolibrary.org/obo/UBERON_0002238	false rib	http://purl.obolibrary.org/obo/UBERON_0002228	rib		A rib that is not directly ventrally connected to the sternum.
http://purl.obolibrary.org/obo/UBERON_0002239	floating rib	http://purl.obolibrary.org/obo/UBERON_0002238	false rib		A rib that is not connected to sternum or sternal cartilage.
http://purl.obolibrary.org/obo/UBERON_0002241	chondrocranium	http://purl.obolibrary.org/obo/UBERON_0011159	primary subdivision of cranial skeletal system		Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD].
http://purl.obolibrary.org/obo/UBERON_0002242	nucleus pulposus	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The jelly-like substance in the middle of the spinal disc which is a remnant of the notochord.
http://purl.obolibrary.org/obo/UBERON_0002244	premaxilla	http://purl.obolibrary.org/obo/UBERON_0011597	bone of upper jaw		One of the bones of the upper jaw situated between and in front of the maxillae[VHOG].
http://purl.obolibrary.org/obo/UBERON_0002245	cerebellar hemisphere	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A paired regions of the cerebellum that lie outside and lateral to the central vermis[MP]. The cerebellum consists of three parts, a median and two lateral, which are continuous with each other, and are substantially the same in structure. The median portion is constricted, and is called the vermis, from its annulated appearance which it owes to the transverse ridges and furrows upon it; the lateral expanded portions are named the hemispheres. The lateral hemisphere is considered the portion of the cerebellum to develop most recently. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002250	popliteal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
http://purl.obolibrary.org/obo/UBERON_0002257	ventral horn of spinal cord	http://purl.obolibrary.org/obo/UBERON_0016550	spinal cord column		The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO].
http://purl.obolibrary.org/obo/UBERON_0002258	dorsal funiculus of spinal cord	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The white substance of the spinal cord lying on either side between the posterior median sulcus and the dorsal root.
http://purl.obolibrary.org/obo/UBERON_0002263	lentiform nucleus	http://purl.obolibrary.org/obo/UBERON_0009663	telencephalic nucleus		The lentiform nucleus or lenticular nucleus comprises the putamen and the globus pallidus within the basal ganglia. It is a large, cone-shaped mass of gray matter just lateral to the internal capsule. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002264	olfactory bulb	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO].
http://purl.obolibrary.org/obo/UBERON_0002265	olfactory tract	http://purl.obolibrary.org/obo/UBERON_0007702	tract of brain		White matter tract that contains projections from the olfactory bulb to other parts of the brain.
http://purl.obolibrary.org/obo/UBERON_0002268	olfactory organ	http://purl.obolibrary.org/obo/UBERON_0000020	sense organ		An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ.
http://purl.obolibrary.org/obo/UBERON_0002270	hyaloid artery	http://purl.obolibrary.org/obo/UBERON_0005492	hyaloid vessel		An artery that is part of the optic stalk of the eye and extends from the optic disc through the vitreous humor to the lens.
http://purl.obolibrary.org/obo/UBERON_0002275	reticular formation	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ).
http://purl.obolibrary.org/obo/UBERON_0002288	choroid plexus of third ventricle	http://purl.obolibrary.org/obo/UBERON_0001886	choroid plexus		Part of choroid plexus contained in the third ventricle.
http://purl.obolibrary.org/obo/UBERON_0002289	midbrain cerebral aqueduct	http://purl.obolibrary.org/obo/UBERON_0004086	brain ventricle		Part of ventricular system of brain consisting of a narrow channel in the midbrain connecting the third and fourth ventricles. (Maryann Martone).
http://purl.obolibrary.org/obo/UBERON_0002290	choroid plexus of fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0006694	cerebellum vasculature		Choroid plexus of the fourth ventricle.
http://purl.obolibrary.org/obo/UBERON_0002291	central canal of spinal cord	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord.
http://purl.obolibrary.org/obo/UBERON_0002294	biliary system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree).
http://purl.obolibrary.org/obo/UBERON_0002299	alveolus of lung	http://purl.obolibrary.org/obo/UBERON_0003215	alveolus		Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP].
http://purl.obolibrary.org/obo/UBERON_0002301	layer of neocortex	http://purl.obolibrary.org/obo/UBERON_8440004	laminar subdivision of the cortex		One of the layers of the neocortex. These layers are defined by distinctive populations of cells based on somata size, shape, or density, that are aligned into sheets.
http://purl.obolibrary.org/obo/UBERON_0002302	myocardium of atrium	http://purl.obolibrary.org/obo/UBERON_0002349	myocardium		The atrial part of middle layer of the heart, comprised of involuntary muscle.
http://purl.obolibrary.org/obo/UBERON_0002305	layer of hippocampus	http://purl.obolibrary.org/obo/UBERON_0016548	central nervous system gray matter layer		The layers of the laminar structure of the hippocampus.
http://purl.obolibrary.org/obo/UBERON_0002307	choroid plexus of lateral ventricle	http://purl.obolibrary.org/obo/UBERON_0001886	choroid plexus		Part of choroid plexus contained in the lateral ventricle.
http://purl.obolibrary.org/obo/UBERON_0002308	nucleus of brain	http://purl.obolibrary.org/obo/UBERON_0000125	neural nucleus		A neural nucleus that is part of the brain.
http://purl.obolibrary.org/obo/UBERON_0002315	gray matter of spinal cord	http://purl.obolibrary.org/obo/UBERON_0002020	gray matter		The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue.
http://purl.obolibrary.org/obo/UBERON_0002316	white matter	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system.
http://purl.obolibrary.org/obo/UBERON_0002317	white matter of cerebellum	http://purl.obolibrary.org/obo/UBERON_0002316	white matter		Regional part of cerebellum consisting of the myelinated axons lying deep to the granule cell layer, excluding the deep cerebellar nuclei and the cerebellar peduncles.
http://purl.obolibrary.org/obo/UBERON_0002318	white matter of spinal cord	http://purl.obolibrary.org/obo/UBERON_0002316	white matter		The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.
http://purl.obolibrary.org/obo/UBERON_0002319	mesangium	http://purl.obolibrary.org/obo/UBERON_0000119	cell layer		The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries.
http://purl.obolibrary.org/obo/UBERON_0002323	coelemic cavity lumen	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.
http://purl.obolibrary.org/obo/UBERON_0002324	muscle of back	http://purl.obolibrary.org/obo/UBERON_0005174	dorsal region element		Any muscle organ that is part of a back [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002325	epithelium of urethra	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes..
http://purl.obolibrary.org/obo/UBERON_0002326	lamina propria of urethra	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a urethra [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002328	notochord	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube.
http://purl.obolibrary.org/obo/UBERON_0002329	somite	http://purl.obolibrary.org/obo/UBERON_0007503	epithelial vesicle		Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
http://purl.obolibrary.org/obo/UBERON_0002331	umbilical cord	http://purl.obolibrary.org/obo/UBERON_0000478	extraembryonic structure		The connecting cord from the developing embryo to the placenta.
http://purl.obolibrary.org/obo/UBERON_0002333	pulmonary trunk	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An arterial trunk which is continuous with the heart and branches into the pulmonary arteries.
http://purl.obolibrary.org/obo/UBERON_0002334	submandibular duct	http://purl.obolibrary.org/obo/UBERON_0001837	duct of salivary gland		The duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue.
http://purl.obolibrary.org/obo/UBERON_0002337	endometrial stroma	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The layer of connective tissue comprised of the endometrial lining of the uterus which fluctuates in thickness throughout the menstrual cycle.
http://purl.obolibrary.org/obo/UBERON_0002338	lamina propria of bronchus	http://purl.obolibrary.org/obo/UBERON_0000031	lamina propria of trachea		A lamina propria that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002342	neural crest	http://purl.obolibrary.org/obo/UBERON_0010316	germ layer / neural crest		A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
http://purl.obolibrary.org/obo/UBERON_0002343	abdomen musculature	http://purl.obolibrary.org/obo/UBERON_0004479	musculature of trunk		Set of all muscles in abdomen.
http://purl.obolibrary.org/obo/UBERON_0002345	descending thoracic aorta	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.
http://purl.obolibrary.org/obo/UBERON_0002346	neurectoderm	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Embryonic ectoderm that gives rise to nervous tissue.
http://purl.obolibrary.org/obo/UBERON_0002347	thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0015008	thoracic vertebra endochondral element		A thoracic vertebra endochondral element that is composed primarily of a bone tissue.
http://purl.obolibrary.org/obo/UBERON_0002350	conducting system of heart	http://purl.obolibrary.org/obo/UBERON_0010131	conducting tissue of heart		The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO].
http://purl.obolibrary.org/obo/UBERON_0002352	atrioventricular node	http://purl.obolibrary.org/obo/UBERON_0010131	conducting tissue of heart		An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.
http://purl.obolibrary.org/obo/UBERON_0002355	pelvic region of trunk	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs.
http://purl.obolibrary.org/obo/UBERON_0002356	perineum	http://purl.obolibrary.org/obo/UBERON_0009569	subdivision of trunk		Subdivision of trunk proper, which is demarcated from the pelvis by the inferior surface of the pelvic diaphragm and from the lower limbs by the perineofemoral lines; together with the thorax, abdomen, and pelvis, it constitutes the trunk[FMA].
http://purl.obolibrary.org/obo/UBERON_0002357	serous pericardium	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		Serous membrane which is divided into parietal and visceral serous pericardium.
http://purl.obolibrary.org/obo/UBERON_0002359	fibrous pericardium	http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ		Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002360	meninx	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Membrane organ that surrounds the brain and the spinal cord.
http://purl.obolibrary.org/obo/UBERON_0002361	pia mater	http://purl.obolibrary.org/obo/UBERON_0000391	leptomeninx		The innermost layer of the leptomeninges, consisting of a delicate membrane closely covering the surface of the brain and spinal cord,and lying under the arachnoid membrane. The pia, unlike the arachnoid, extends into the sulci in gyrencephalic animals.
http://purl.obolibrary.org/obo/UBERON_0002362	arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0000391	leptomeninx		A think avascular meningeal layer, between the pia mater and the dural mater. It is separated from the pia mater by the subarachnoid space.
http://purl.obolibrary.org/obo/UBERON_0002363	dura mater	http://purl.obolibrary.org/obo/UBERON_0002360	meninx		Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections.
http://purl.obolibrary.org/obo/UBERON_0002365	exocrine gland	http://purl.obolibrary.org/obo/UBERON_0002530	gland		A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas.
http://purl.obolibrary.org/obo/UBERON_0002374	metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		A bone that is part of the metacarpal skeleton.
http://purl.obolibrary.org/obo/UBERON_0002375	cricoid cartilage	http://purl.obolibrary.org/obo/UBERON_0001739	laryngeal cartilage		A cartilaginous ring that provides support for the arytenoid cartilages and forms the caudal part of the larynx.
http://purl.obolibrary.org/obo/UBERON_0002376	cranial muscle	http://purl.obolibrary.org/obo/UBERON_0010959	craniocervical muscle		Any skeletal muscle that is part of the head region.
http://purl.obolibrary.org/obo/UBERON_0002377	muscle of neck	http://purl.obolibrary.org/obo/UBERON_0010959	craniocervical muscle		Any muscle that is part of the cervical (neck) region.
http://purl.obolibrary.org/obo/UBERON_0002378	muscle of abdomen	http://purl.obolibrary.org/obo/UBERON_0005172	abdomen element		Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis.
http://purl.obolibrary.org/obo/UBERON_0002379	perineal muscle	http://purl.obolibrary.org/obo/UBERON_0001325	muscle of pelvis		Any muscle organ that is part of a perineum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002380	trapezius muscle	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		A large superficial muscle that extends longitudinally from the occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula (shoulder blade). Its functions are to move the scapulae and support the arm. The trapezius has three functional regions: the superior region (descending part), which supports the weight of the arm; the intermediate region (transverse part), which retracts the scapulae; and the inferior region (ascending part), which medially rotates and depresses the scapulae. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002381	pectoralis major	http://purl.obolibrary.org/obo/UBERON_0001495	pectoral muscle		The pectoralis major is a thick, fan-shaped muscle, situated at the upper front of the chest wall. It makes up the bulk of the chest muscles in the male and lies under the breast in the female. Underneath the pectoralis major is the pectoralis minor, a thin, triangular muscle. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002382	rectus abdominis muscle	http://purl.obolibrary.org/obo/UBERON_0002461	anterior abdominal wall muscle		The rectus abdominis muscle is a paired muscle running vertically on each side of the anterior wall of the abdomen. There are two parallel sets of muscles, separated by a midline band of connective tissue called the linea alba (white line). It extends from the pubic symphysis/pubic crest inferiorly to the xiphisternum/xiphoid process and lower costal cartilages (5-7) superiorly. It is contained in the Rectus sheath. The rectus is usually crossed by three fibrous bands licked by the tendinous inscriptions. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0002392	nasolacrimal duct	http://purl.obolibrary.org/obo/UBERON_0000058	duct		The paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity.
http://purl.obolibrary.org/obo/UBERON_0002393	pharyngotympanic tube	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Organ with organ cavity which connects the cavity of the middle ear to the cavity of the pharynx. Examples: There are only two pharyngotympanic tubes, the right and the left pharyngotympanic tubes.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002395	talus	http://purl.obolibrary.org/obo/UBERON_0011679	proximal tarsal bone		A proximal tarsal bone resulting from fusion of intermedium and fibulare.
http://purl.obolibrary.org/obo/UBERON_0002396	vomer	http://purl.obolibrary.org/obo/UBERON_0012071	palate bone		The triangular flat bone of the nasal septum.
http://purl.obolibrary.org/obo/UBERON_0002397	maxilla	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The bone which normally forms the lateral upper jaw in osteichthyans, including tetrapods.
http://purl.obolibrary.org/obo/UBERON_0002400	parietal pleura	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		The outer serous membrane of the pulmonary pleural.
http://purl.obolibrary.org/obo/UBERON_0002401	visceral pleura	http://purl.obolibrary.org/obo/UBERON_0022350	visceral serous membrane		The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs.
http://purl.obolibrary.org/obo/UBERON_0002402	pleural cavity	http://purl.obolibrary.org/obo/UBERON_0035809	serous cavity		The fluid-filled cavity that lies between the visceral and parietal pleurae.
http://purl.obolibrary.org/obo/UBERON_0002406	pericardial sac	http://purl.obolibrary.org/obo/UBERON_0005906	serous sac		A double-walled sac containing the heart and the roots of the great vessels.
http://purl.obolibrary.org/obo/UBERON_0002408	parietal serous pericardium	http://purl.obolibrary.org/obo/UBERON_0022351	parietal serous membrane		Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac.
http://purl.obolibrary.org/obo/UBERON_0002409	pericardial fluid	http://purl.obolibrary.org/obo/UBERON_0036217	coelomic fluid		Transudate contained in the pericardial cavity.[FMA].
http://purl.obolibrary.org/obo/UBERON_0002412	vertebra	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0002413	cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0015007	cervical vertebra endochondral element		A vertebra that is located in the cervical region of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0002414	lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0015009	lumbar vertebra endochondral element		Large vertebra of the movable part of the vertebral column, characterized by the absence of the foramen transversarium within the transverse process, and by the absence of facets on the sides of the body.
http://purl.obolibrary.org/obo/UBERON_0002415	tail	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail.
http://purl.obolibrary.org/obo/UBERON_0002417	abdominal segment of trunk	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		The abdominal segment of the torso.
http://purl.obolibrary.org/obo/UBERON_0002418	cartilage tissue	http://purl.obolibrary.org/obo/UBERON_0004755	skeletal tissue		Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.
http://purl.obolibrary.org/obo/UBERON_0002419	skin gland	http://purl.obolibrary.org/obo/UBERON_0006003	integumentary adnexa		A gland that is part of a skin of body [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002421	hippocampal formation	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment].
http://purl.obolibrary.org/obo/UBERON_0002422	fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0004086	brain ventricle		Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures.
http://purl.obolibrary.org/obo/UBERON_0002423	hepatobiliary system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		The part of the digestive system that contains the liver and the biliary system.
http://purl.obolibrary.org/obo/UBERON_0002424	oral epithelium	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues.
http://purl.obolibrary.org/obo/UBERON_0002425	visceral serous pericardium	http://purl.obolibrary.org/obo/UBERON_0022350	visceral serous membrane		Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA].
http://purl.obolibrary.org/obo/UBERON_0002426	chest muscle	http://purl.obolibrary.org/obo/UBERON_0005175	chest organ		Any muscle organ that is part of a chest [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002427	arm skin	http://purl.obolibrary.org/obo/UBERON_0003531	forelimb skin		A zone of skin that is part of an arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002428	limb bone	http://purl.obolibrary.org/obo/UBERON_0015061	limb endochondral element		A bone that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002429	cervical lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002435	striatum	http://purl.obolibrary.org/obo/UBERON_0011300	gray matter of telencephalon		A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO].
http://purl.obolibrary.org/obo/UBERON_0002437	cerebral hemisphere white matter	http://purl.obolibrary.org/obo/UBERON_0011299	white matter of telencephalon		White matter that is part of a cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002443	choroidal blood vessel	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A blood vessel that is part of a choroid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002445	ulnare	http://purl.obolibrary.org/obo/UBERON_0001480	proximal carpal bone		The postaxial bone of the proximal carpal region. Found in close approximation to the ulna, often in articulation[PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0002450	decidua	http://purl.obolibrary.org/obo/UBERON_0000478	extraembryonic structure		The maternal uterine-derived portion of the placenta.
http://purl.obolibrary.org/obo/UBERON_0002451	endometrial gland	http://purl.obolibrary.org/obo/UBERON_0005398	female reproductive gland		The mucous secreting gland associated with the mucuous membrane lining the uterus.
http://purl.obolibrary.org/obo/UBERON_0002456	internal thoracic artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		An artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002457	intersomitic artery	http://purl.obolibrary.org/obo/UBERON_0014907	intersomitic vessel		The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries.
http://purl.obolibrary.org/obo/UBERON_0002458	spinal artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		Arteries that supply the spinal cord.
http://purl.obolibrary.org/obo/UBERON_0002459	inferior palpebral vein	http://purl.obolibrary.org/obo/UBERON_0014769	palpebral vein		A blood vessel that drains from from an lower eyelid.
http://purl.obolibrary.org/obo/UBERON_0002460	vesical vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A tributary of the iliac vein that drains the urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0002461	anterior abdominal wall muscle	http://purl.obolibrary.org/obo/UBERON_0002378	muscle of abdomen		Any skeletal muscle organ that is part of a anterior abdominal wall. Examples: the obliques, pyramidalis and transversus abdominus.
http://purl.obolibrary.org/obo/UBERON_0002463	muscle of posterior compartment of hindlimb stylopod	http://purl.obolibrary.org/obo/UBERON_0004252	hindlimb stylopod muscle		Any of the posterior thigh muscles. [WP,modified].
http://purl.obolibrary.org/obo/UBERON_0002465	lymphoid system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP].
http://purl.obolibrary.org/obo/UBERON_0002466	intestine secretion	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine.
http://purl.obolibrary.org/obo/UBERON_0002469	esophagus mucosa	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002470	autopod region	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot.
http://purl.obolibrary.org/obo/UBERON_0002471	zeugopod	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus).
http://purl.obolibrary.org/obo/UBERON_0002472	stylopod	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		The proximal free limb segment. Includes as parts the stylopod skeleton.
http://purl.obolibrary.org/obo/UBERON_0002473	intercerebral commissure	http://purl.obolibrary.org/obo/UBERON_0019294	commissure of telencephalon		A commissure that connects the two cerebral hemispheres. Examples: anterior commissure, corpus callosum.
http://purl.obolibrary.org/obo/UBERON_0002474	cerebellar peduncular complex	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		A composite structure of the brain stem, which is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)[NIF, based on NN].
http://purl.obolibrary.org/obo/UBERON_0002478	orbitosphenoid	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young.
http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue	http://purl.obolibrary.org/obo/UBERON_0004755	skeletal tissue		Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.
http://purl.obolibrary.org/obo/UBERON_0002482	lamellar bone	http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue		Bone tissue that has a regular parallel alignment of collagen into sheets (lamellae) and is mechanically strong.
http://purl.obolibrary.org/obo/UBERON_0002483	trabecular bone tissue	http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue		Bone tissue that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow.
http://purl.obolibrary.org/obo/UBERON_0002484	bone marrow cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The medullary cavities of the bones where bone marrow is stored.
http://purl.obolibrary.org/obo/UBERON_0002485	prostate duct	http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system		The minute canals that pass the prostatic secretions to the urethra.
http://purl.obolibrary.org/obo/UBERON_0002488	helix of outer ear	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		The helix is the prominent rim of the pinna.
http://purl.obolibrary.org/obo/UBERON_0002489	coronal suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		The dense, fibrous connective tissue joint between the tetrapod parietal bones and the frontal bone.
http://purl.obolibrary.org/obo/UBERON_0002490	frontal suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		A suture that connects the two frontal bones of the skull.
http://purl.obolibrary.org/obo/UBERON_0002491	lambdoid suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		The dense, fibrous connective tissue joint between the parietal bones and the occipital bone.
http://purl.obolibrary.org/obo/UBERON_0002492	sagittal suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		The dense, fibrous connective tissue joint between the tetrapod parietal bones.
http://purl.obolibrary.org/obo/UBERON_0002497	acromion	http://purl.obolibrary.org/obo/UBERON_0004530	bony projection		Region of the scapula where the latter meets with the clavicle: attachment point of the clavicle to the scapula in some taxa.
http://purl.obolibrary.org/obo/UBERON_0002498	deltopectoral crest	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		A rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches.
http://purl.obolibrary.org/obo/UBERON_0002499	cochlear labyrinth	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The labyrinth is a system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. It is named by analogy with the mythical maze that imprisoned the Minotaur, because of its appearance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002500	zygomatic arch	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone.
http://purl.obolibrary.org/obo/UBERON_0002503	greater trochanter	http://purl.obolibrary.org/obo/UBERON_0000980	trochanter		The greater trochanter (great trochanter) of the femur is a large, irregular, quadrilateral eminence and a part of the skeletal system. It is directed a little lateralward and backward, and, in the adult, is about 1 cm lower than the head. Because the pelvic outlet in the female is larger than in the male, there is a greater distance between the greater trochanters in the female. It has two surfaces and four borders. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002504	lesser trochanter	http://purl.obolibrary.org/obo/UBERON_0000980	trochanter		The lesser trochanter (small trochanter) of the femur is a conical eminence, which varies in size in different subjects [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002506	iris epithelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		An epithelium that is part of a iris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002507	abdominal lymph node	http://purl.obolibrary.org/obo/UBERON_0005172	abdomen element		A lymph node that is part of an abdomen [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002509	mesenteric lymph node	http://purl.obolibrary.org/obo/UBERON_0015860	visceral abdominal lymph node		The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group.
http://purl.obolibrary.org/obo/UBERON_0002510	anterior fontanel	http://purl.obolibrary.org/obo/UBERON_0002221	fontanelle		In humans, the anterior fontanelle (bregmatic fontanelle, frontal fontanelle) is the largest, and is placed at the junction of the sagittal suture, coronal suture, and frontal suture; it is lozenge-shaped, and measures about 4 cm in its antero-posterior and 2.5 cm in its transverse diameter. The fontanelle allows the skull to deform during birth to ease its passage through the birth canal and for expansion of the brain after birth. While the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior is not completely closed until about the middle of the second year. Full ossification starts in the late twenties and finishes before the age of 50 . [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002513	endochondral bone	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		Replacement bone that forms within cartilage.
http://purl.obolibrary.org/obo/UBERON_0002514	intramembranous bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].
http://purl.obolibrary.org/obo/UBERON_0002515	periosteum	http://purl.obolibrary.org/obo/UBERON_0000158	membranous layer		The thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints.
http://purl.obolibrary.org/obo/UBERON_0002516	epiphyseal plate	http://purl.obolibrary.org/obo/UBERON_0001994	hyaline cartilage tissue		A hyaline cartilage plate in the metaphysis at each end of a long bone. The plate is found in children and adolescents; in adults, who have stopped growing, the plate is replaced by an epiphyseal line.
http://purl.obolibrary.org/obo/UBERON_0002517	basicranium	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof.
http://purl.obolibrary.org/obo/UBERON_0002521	elastic tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		Connective tissue composed of elastic fibers.
http://purl.obolibrary.org/obo/UBERON_0002522	tunica media	http://purl.obolibrary.org/obo/UBERON_0004797	blood vessel layer		The middle layer of an artery or vein. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002523	tunica intima	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong].
http://purl.obolibrary.org/obo/UBERON_0002527	pancreatic lymph node	http://purl.obolibrary.org/obo/UBERON_0002507	abdominal lymph node		A lymph node that is part of a pancreas [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002528	sacral lymph node	http://purl.obolibrary.org/obo/UBERON_0005179	pelvic region element		A lymph node located in the sacral region.
http://purl.obolibrary.org/obo/UBERON_0002529	limb segment	http://purl.obolibrary.org/obo/UBERON_0010538	paired limb/fin segment		A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles.
http://purl.obolibrary.org/obo/UBERON_0002530	gland	http://purl.obolibrary.org/obo/UBERON_0000062	organ		An organ that functions as a secretory or excretory organ.
http://purl.obolibrary.org/obo/UBERON_0002532	epiblast (generic)	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA].
http://purl.obolibrary.org/obo/UBERON_0002533	post-anal tail bud	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node.
http://purl.obolibrary.org/obo/UBERON_0002537	hermaphrodite gonad	http://purl.obolibrary.org/obo/UBERON_0000991	gonad		A gonad with both testicular and ovarian aspects[WP].
http://purl.obolibrary.org/obo/UBERON_0002539	pharyngeal arch	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches.
http://purl.obolibrary.org/obo/UBERON_0002544	digit	http://purl.obolibrary.org/obo/UBERON_0005881	autopodial extension		A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans).
http://purl.obolibrary.org/obo/UBERON_0002546	cranial placode	http://purl.obolibrary.org/obo/UBERON_0005085	ectodermal placode		Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.
http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.
http://purl.obolibrary.org/obo/UBERON_0002561	lumen of central nervous system	http://purl.obolibrary.org/obo/UBERON_0002558	organ cavity		The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube.
http://purl.obolibrary.org/obo/UBERON_0002567	basal part of pons	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Ventral subdivision of the pons which consists of the massive pontine pertuberance on pontine ventral surface.
http://purl.obolibrary.org/obo/UBERON_0002588	decussation of superior cerebellar peduncle	http://purl.obolibrary.org/obo/UBERON_0007418	neural decussation		Regional part of superior cerebellar peduncle located in the caudal midbrain, at the level of the inferior colliculus, consisting of a large bundle of fibers crossing the midline. It contains fibers projecting from the deep cerebellar nucleus to the midbrain and thalamus through the superior cerebellar peduncle (MM). The decussation of superior cerebellar peduncle is the portion of the superior cerebellar peduncle which crosses into the midbrain. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002589	lateral corticospinal tract	http://purl.obolibrary.org/obo/UBERON_0007702	tract of brain		Part of the corticospinal tract located in the spinal cord, formed as 75 to 90% of the corticospinal fibers cross to the opposite side of the brainstem in the pyramidal decussation. This tract descends the length of the spinal cord in the lateral white column (Adapted from Brain Info).
http://purl.obolibrary.org/obo/UBERON_0002600	limbic lobe	http://purl.obolibrary.org/obo/UBERON_0016526	lobe of cerebral hemisphere		Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem.
http://purl.obolibrary.org/obo/UBERON_0002610	cochlear nuclear complex	http://purl.obolibrary.org/obo/UBERON_0019263	gray matter of hindbrain		The cochlear nuclei consist of: (a) the dorsal cochlear nucleus, corresponding to the tuberculum acusticum on the dorso-lateral surface of the inferior peduncle; and (b) the ventral or accessory cochlear nucleus, placed between the two divisions of the nerve, on the ventral aspect of the inferior peduncle. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain	http://purl.obolibrary.org/obo/UBERON_0000073	regional part of nervous system		Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.
http://purl.obolibrary.org/obo/UBERON_0002663	septal nuclear complex	http://purl.obolibrary.org/obo/UBERON_0007245	nuclear complex of neuraxis		Collection of nerve cells in the medial forebrain lying generally in front of the anterior commissure (Maryann Martone).
http://purl.obolibrary.org/obo/UBERON_0002673	vestibular nuclear complex	http://purl.obolibrary.org/obo/UBERON_0019263	gray matter of hindbrain		Nuclear complex containing the vestibular nuclei.
http://purl.obolibrary.org/obo/UBERON_0002682	abducens nucleus	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		Nucleus located beneath the floor of the 4th ventricle in the pontine tegmentum, containing motor neurons innervating the lateral rectus muscle of the eye (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533).
http://purl.obolibrary.org/obo/UBERON_0002707	corticospinal tract	http://purl.obolibrary.org/obo/UBERON_0001018	axon tract		The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract.
http://purl.obolibrary.org/obo/UBERON_0002722	trochlear nucleus	http://purl.obolibrary.org/obo/UBERON_0009661	midbrain nucleus		Nucleus in the midbrain at the level of the inferior colliculus near the midline, containing the motor neurons giving rise to the trochlear nerve, innervating the contralateral superior oblique extraocular muscle of the eye (Brodal, Neurological Anatomy, 3rd ed, 1981, pg. 533).
http://purl.obolibrary.org/obo/UBERON_0002726	cervical spinal cord	http://purl.obolibrary.org/obo/UBERON_0005844	spinal cord segment		A spinal cord segment that adjacent_to a cervical region.
http://purl.obolibrary.org/obo/UBERON_0002742	lamina of septum pellucidum	http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer		One of two layers of both white and gray matter of the septum pellucidum. During fetal development there is a space between the two laminae called the cavum septum pellucidum which, in ninety per cent of cases, disappears during infancy.
http://purl.obolibrary.org/obo/UBERON_0002743	basal forebrain	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert.
http://purl.obolibrary.org/obo/UBERON_0002749	regional part of cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		A regional part of brain that is part of a cerebellar cortex [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0002787	decussation of trochlear nerve	http://purl.obolibrary.org/obo/UBERON_0007418	neural decussation		The crossing of the two trochlear nerves at their exit through the velum medullare anterius.
http://purl.obolibrary.org/obo/UBERON_0002802	left parietal lobe	http://purl.obolibrary.org/obo/UBERON_0001872	parietal lobe		Parietal lobe of the left hemisphere of the brain.
http://purl.obolibrary.org/obo/UBERON_0002803	right parietal lobe	http://purl.obolibrary.org/obo/UBERON_0001872	parietal lobe		Parietal lobe of the right hemisphere of the brain.
http://purl.obolibrary.org/obo/UBERON_0002804	left limbic lobe	http://purl.obolibrary.org/obo/UBERON_0002600	limbic lobe		A limbic lobe that is part of a left cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002805	right limbic lobe	http://purl.obolibrary.org/obo/UBERON_0002600	limbic lobe		A limbic lobe that is part of a right cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002808	left temporal lobe	http://purl.obolibrary.org/obo/UBERON_0001871	temporal lobe		A temporal lobe that is part of a left cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002809	right temporal lobe	http://purl.obolibrary.org/obo/UBERON_0001871	temporal lobe		A temporal lobe that is part of a right cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002810	right frontal lobe	http://purl.obolibrary.org/obo/UBERON_0001870	frontal cortex		A frontal cortex that is part of a right cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002811	left frontal lobe	http://purl.obolibrary.org/obo/UBERON_0001870	frontal cortex		A frontal cortex that is part of a left cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0002812	left cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0001869	cerebral hemisphere		A cerebral hemisphere that is in the left side of a brain.
http://purl.obolibrary.org/obo/UBERON_0002813	right cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0001869	cerebral hemisphere		A cerebral hemisphere that is in the right side of a brain.
http://purl.obolibrary.org/obo/UBERON_0002824	vestibular ganglion	http://purl.obolibrary.org/obo/UBERON_0001800	sensory ganglion		The ganglion of the vestibular nerve. It contains the cell bodies of the bipolar primary afferent neurons whose peripheral processes form synaptic contact with hair cells of the vestibular sensory end organs[WP,unvetted]. Distributed to the maculae of the utricle and saccule and to the ampullary crests of the semicircular ducts. The vestibular fibers arise in bipolar cells in the vestibular ganglion in the internal acoustic meatus.
http://purl.obolibrary.org/obo/UBERON_0002827	vestibulocochlear ganglion	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia.
http://purl.obolibrary.org/obo/UBERON_0002871	hypoglossal nucleus	http://purl.obolibrary.org/obo/UBERON_0007635	nucleus of medulla oblongata		Nucleus forming a longitudinal cell column in the medulla, close beneath the floor of the 4th ventricle, containing motor neurons that innervate the muscles of the tongue (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 453).
http://purl.obolibrary.org/obo/UBERON_0002916	central sulcus	http://purl.obolibrary.org/obo/UBERON_0013118	sulcus of brain		The central sulcus is a fold in the cerebral cortex of brains in vertebrates. Also called the central fissure, it was originally called the fissure of Rolando or the Rolandic fissure, after Luigi Rolando. The central sulcus is a prominent landmark of the brain, separating the parietal lobe from the frontal lobe and the primary motor cortex from the primary somatosensory cortex. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002921	longitudinal fissure	http://purl.obolibrary.org/obo/UBERON_0014466	subarachnoid fissure		The deep groove which separates the two hemispheres of the vertebrate brain. The falx cerebri, a dural brain covering, lies within the medial longitudinal fissure. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0002925	trigeminal nucleus	http://purl.obolibrary.org/obo/UBERON_0000126	cranial nerve nucleus		A nucleus of brain that is part of a trigeminal nuclear complex.
http://purl.obolibrary.org/obo/UBERON_0002926	gustatory epithelium	http://purl.obolibrary.org/obo/UBERON_0006934	sensory epithelium		A sensory epithelium that is part of a gustatory system.
http://purl.obolibrary.org/obo/UBERON_0002956	granular layer of cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0004130	cerebellar layer		The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.
http://purl.obolibrary.org/obo/UBERON_0002974	molecular layer of cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0004130	cerebellar layer		The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.
http://purl.obolibrary.org/obo/UBERON_0002979	Purkinje cell layer of cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0004130	cerebellar layer		The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.
http://purl.obolibrary.org/obo/UBERON_0003023	pontine tegmentum	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133).
http://purl.obolibrary.org/obo/UBERON_0003037	septum	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A wall, dividing a cavity or structure into smaller ones[WP].
http://purl.obolibrary.org/obo/UBERON_0003038	thoracic spinal cord	http://purl.obolibrary.org/obo/UBERON_0005844	spinal cord segment		The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0003039	anterior commissure anterior part	http://purl.obolibrary.org/obo/UBERON_0019294	commissure of telencephalon		The horseshoe-shaped tract that connects the two olfactory bulbs.
http://purl.obolibrary.org/obo/UBERON_0003041	trigeminal nerve fibers	http://purl.obolibrary.org/obo/UBERON_0006134	nerve fiber		A nerve fiber that is part of a trigeminal nerve.
http://purl.obolibrary.org/obo/UBERON_0003043	posterior part of anterior commissure	http://purl.obolibrary.org/obo/UBERON_0019294	commissure of telencephalon		The major forebrain commissure that connects the two temporal lobes of the cortex.
http://purl.obolibrary.org/obo/UBERON_0003050	olfactory placode	http://purl.obolibrary.org/obo/UBERON_0009955	neurogenic placode		A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity.
http://purl.obolibrary.org/obo/UBERON_0003051	ear vesicle	http://purl.obolibrary.org/obo/UBERON_0007499	epithelial sac		An epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP].
http://purl.obolibrary.org/obo/UBERON_0003052	midbrain-hindbrain boundary	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.
http://purl.obolibrary.org/obo/UBERON_0003054	roof plate	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		A single row of glia at the dorsal midline of the developing neural tube along the entire anterior-posterior axis. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells.
http://purl.obolibrary.org/obo/UBERON_0003055	periderm	http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure		The outermost layer (or layers, depending on the species) of embryonic skin, essential for the development of the epidermis and establishment of the barrier functions. The periderm derives from the outer layer of the ectoderm.
http://purl.obolibrary.org/obo/UBERON_0003056	pre-chordal neural plate	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The portion of neural plate anterior to the mid-hindbrain junction.
http://purl.obolibrary.org/obo/UBERON_0003057	chordal neural plate	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The portion of neural plate posterior to the mid-hindbrain junction.
http://purl.obolibrary.org/obo/UBERON_0003059	presomitic mesoderm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
http://purl.obolibrary.org/obo/UBERON_0003060	pronephric duct	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP].
http://purl.obolibrary.org/obo/UBERON_0003061	blood island	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted].
http://purl.obolibrary.org/obo/UBERON_0003063	prechordal plate	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue.
http://purl.obolibrary.org/obo/UBERON_0003064	intermediate mesoderm	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.
http://purl.obolibrary.org/obo/UBERON_0003066	pharyngeal arch 2	http://purl.obolibrary.org/obo/UBERON_0002539	pharyngeal arch		The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements.
http://purl.obolibrary.org/obo/UBERON_0003067	dorsolateral placode	http://purl.obolibrary.org/obo/UBERON_0009955	neurogenic placode		Lateral neurogenic placodes positioned dorsal of the epibranchial placodes.
http://purl.obolibrary.org/obo/UBERON_0003068	axial mesoderm	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.
http://purl.obolibrary.org/obo/UBERON_0003069	otic placode	http://purl.obolibrary.org/obo/UBERON_0003067	dorsolateral placode		A cranial placode which, once specified, invaginates to form an otic cup, which eventually separates from the surface ectoderm to form the otic vesicle or otocyst, a rounded structure without appar- ent polarity. As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII[NBK].
http://purl.obolibrary.org/obo/UBERON_0003070	trigeminal placode complex	http://purl.obolibrary.org/obo/UBERON_0003067	dorsolateral placode		A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion.
http://purl.obolibrary.org/obo/UBERON_0003072	optic cup	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP].
http://purl.obolibrary.org/obo/UBERON_0003073	lens placode	http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode		A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP].
http://purl.obolibrary.org/obo/UBERON_0003075	neural plate	http://purl.obolibrary.org/obo/UBERON_0016879	future central nervous system		A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
http://purl.obolibrary.org/obo/UBERON_0003077	paraxial mesoderm	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
http://purl.obolibrary.org/obo/UBERON_0003078	epibranchial placode	http://purl.obolibrary.org/obo/UBERON_0009955	neurogenic placode		Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia.
http://purl.obolibrary.org/obo/UBERON_0003081	lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].
http://purl.obolibrary.org/obo/UBERON_0003082	myotome	http://purl.obolibrary.org/obo/UBERON_0017650	developing mesenchymal structure		A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells.
http://purl.obolibrary.org/obo/UBERON_0003083	trunk neural crest	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia].
http://purl.obolibrary.org/obo/UBERON_0003084	heart primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
http://purl.obolibrary.org/obo/UBERON_0003086	caudal artery	http://purl.obolibrary.org/obo/UBERON_0003524	tail blood vessel		Extension of the dorsal aorta in the tail.
http://purl.obolibrary.org/obo/UBERON_0003089	sclerotome	http://purl.obolibrary.org/obo/UBERON_0007530	migrating mesenchyme population		Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
http://purl.obolibrary.org/obo/UBERON_0003091	thyroid primordium	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus.
http://purl.obolibrary.org/obo/UBERON_0003098	optic stalk	http://purl.obolibrary.org/obo/UBERON_0034705	developing neuroepithelium		The narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain.
http://purl.obolibrary.org/obo/UBERON_0003099	cranial neural crest	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage.
http://purl.obolibrary.org/obo/UBERON_0003100	female organism	http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism		Gonochoristic organism that can produce female gametes.
http://purl.obolibrary.org/obo/UBERON_0003101	male organism	http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism		Gonochoristic organism that can produce male gametes.
http://purl.obolibrary.org/obo/UBERON_0003102	surface structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.
http://purl.obolibrary.org/obo/UBERON_0003103	compound organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.
http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0003107	Meckel's cartilage	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		Meckel's cartilage is the bilaterally paired, rod-like, cartilaginous ventral component of the lower jar, or ventral mandibular arch. It is typically resorbed in adults.
http://purl.obolibrary.org/obo/UBERON_0003111	sphenoid region	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Anatomical cluster that forms the floor and sidewalls of the middle part of the cranium.
http://purl.obolibrary.org/obo/UBERON_0003112	olfactory region	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ.
http://purl.obolibrary.org/obo/UBERON_0003113	dermatocranium	http://purl.obolibrary.org/obo/UBERON_0011159	primary subdivision of cranial skeletal system		Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified].
http://purl.obolibrary.org/obo/UBERON_0003114	pharyngeal arch 3	http://purl.obolibrary.org/obo/UBERON_0002539	pharyngeal arch		The third branchial arch contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus.
http://purl.obolibrary.org/obo/UBERON_0003115	pharyngeal arch 4	http://purl.obolibrary.org/obo/UBERON_0002539	pharyngeal arch		Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus.
http://purl.obolibrary.org/obo/UBERON_0003117	pharyngeal arch 6	http://purl.obolibrary.org/obo/UBERON_0002539	pharyngeal arch		The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles.
http://purl.obolibrary.org/obo/UBERON_0003118	pharyngeal arch artery 1	http://purl.obolibrary.org/obo/UBERON_0004363	pharyngeal arch artery		The vessels formed within the first pair of branchial arches in embryogenesis.
http://purl.obolibrary.org/obo/UBERON_0003119	pharyngeal arch artery 2	http://purl.obolibrary.org/obo/UBERON_0004363	pharyngeal arch artery		The vessels formed within the second pair of branchial arches in embryogenesis.
http://purl.obolibrary.org/obo/UBERON_0003120	pharyngeal arch artery 3	http://purl.obolibrary.org/obo/UBERON_0004363	pharyngeal arch artery		The vessels formed within the third pair of branchial arches in embryogenesis.
http://purl.obolibrary.org/obo/UBERON_0003121	pharyngeal arch artery 4	http://purl.obolibrary.org/obo/UBERON_0004363	pharyngeal arch artery		The vessels formed within the fourth pair of branchial arches in embryogenesis.
http://purl.obolibrary.org/obo/UBERON_0003123	pharyngeal arch artery 6	http://purl.obolibrary.org/obo/UBERON_0004363	pharyngeal arch artery		The vessels formed within the sixth pair of branchial arches in embryogenesis.
http://purl.obolibrary.org/obo/UBERON_0003124	chorion membrane	http://purl.obolibrary.org/obo/UBERON_0005631	extraembryonic membrane		The outermost extraembryonic membrane of amniotes.
http://purl.obolibrary.org/obo/UBERON_0003128	cranium	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Upper portion of the skull that excludes the mandible (when present in the organism).
http://purl.obolibrary.org/obo/UBERON_0003212	gustatory organ	http://purl.obolibrary.org/obo/UBERON_0000005	chemosensory organ		Any sense organ that functions in (some) detection of chemical stimulus involved in sensory perception of taste (GO:0050912).
http://purl.obolibrary.org/obo/UBERON_0003214	mammary gland alveolus	http://purl.obolibrary.org/obo/UBERON_0003215	alveolus		A sac-like structure that is found in the mature gland[GO].
http://purl.obolibrary.org/obo/UBERON_0003215	alveolus	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Organ part that has the form of a hollow cavity[WP].
http://purl.obolibrary.org/obo/UBERON_0003218	ovary septum	http://purl.obolibrary.org/obo/UBERON_0003037	septum		Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO].
http://purl.obolibrary.org/obo/UBERON_0003220	metanephric mesenchyme	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		One of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0003224	chorion syncytiotrophoblast	http://purl.obolibrary.org/obo/UBERON_0000478	extraembryonic structure		An extraembryonic structure that develops_from a syncytiotrophoblast and is part of a chorion.
http://purl.obolibrary.org/obo/UBERON_0003229	epithelium of elbow	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a elbow [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003230	epithelium of carpal region	http://purl.obolibrary.org/obo/UBERON_0000490	unilaminar epithelium		An epithelium that is part of a wrist [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003231	epithelium of hip	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a hip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003232	epithelium of knee	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a knee [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003233	epithelium of shoulder	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a shoulder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003235	epithelium of upper jaw	http://purl.obolibrary.org/obo/UBERON_0035037	jaw epithelium		An epithelium that is part of a upper jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003236	epithelium of lower jaw	http://purl.obolibrary.org/obo/UBERON_0035037	jaw epithelium		An epithelium that is part of a lower jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003243	epithelium of cochlear duct	http://purl.obolibrary.org/obo/UBERON_0006937	inner ear epithelium		An epithelium that is part of a cochlear duct of membranous labyrinth [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003244	epithelium of mammary gland	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		The epithelial layer of the luminal surfaces of the mammary gland.
http://purl.obolibrary.org/obo/UBERON_0003247	epithelium of forearm	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003248	epithelium of footplate	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An epithelium that is part of a footplate.
http://purl.obolibrary.org/obo/UBERON_0003249	epithelium of otic placode	http://purl.obolibrary.org/obo/UBERON_0015807	ear epithelium		An epithelium that is part of a otic placode [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003252	thoracic rib cage	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Subdivision of skeletal system that consists of all ribs in an organism connected to the sternum and the vertebrae. Some vertebrates have abdominal ribs (gastrialia), not connected to the vertebrate - these are not considered part of the rib case.
http://purl.obolibrary.org/obo/UBERON_0003253	neck of rib	http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element		The neck of the rib is the flattened portion which extends lateralward from the head; it is about 2.5 cm. long, and is placed in front of the transverse process of the lower of the two vertebrC& with which the head articulates. Its anterior surface is flat and smooth, its posterior rough for the attachment of the ligament of the neck, and perforated by numerous foramina. Of its two borders the superior presents a rough crest (crista colli costE) for the attachment of the anterior costotransverse ligament; its inferior border is rounded. On the posterior surface at the junction of the neck and body, and nearer the lower than the upper border, is an eminencebthe tubercle; it consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrC& to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs.
http://purl.obolibrary.org/obo/UBERON_0003257	yolk sac endoderm	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		The portion of the yolk sac that is derived from endoderm and lines the yolk sac.
http://purl.obolibrary.org/obo/UBERON_0003258	endoderm of foregut	http://purl.obolibrary.org/obo/UBERON_0015833	foregut epithelium		An endoderm that is part of a foregut [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003259	endoderm of midgut	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An endoderm that is part of a midgut [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003260	endoderm of hindgut	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An endoderm that is part of a hindgut [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003261	thyroid primordium endoderm	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		An endoderm that is part of a thyroid primordium.
http://purl.obolibrary.org/obo/UBERON_0003262	amniotic mesoderm	http://purl.obolibrary.org/obo/UBERON_0010333	extraembryonic membrane mesenchyme		A mesenchyme that is part of a amnion.
http://purl.obolibrary.org/obo/UBERON_0003265	chorionic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010333	extraembryonic membrane mesenchyme		A mesenchyme that is part of a chorion.
http://purl.obolibrary.org/obo/UBERON_0003267	tooth of upper jaw	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A calcareous tooth that is part of the upper jaw region. In mammals, the upper jaw teeth are attached to the maxilla.
http://purl.obolibrary.org/obo/UBERON_0003268	tooth of lower jaw	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A calcareous tooth that is part of the lower jaw region. In mammals, the lower jaw teeth are attached to the mandible (dentary).
http://purl.obolibrary.org/obo/UBERON_0003269	skeletal muscle tissue of eye	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003277	skeleton of upper jaw	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones.
http://purl.obolibrary.org/obo/UBERON_0003278	skeleton of lower jaw	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage.
http://purl.obolibrary.org/obo/UBERON_0003279	endothelium of trachea	http://purl.obolibrary.org/obo/UBERON_0001986	endothelium		An endothelium that is part of a trachea.
http://purl.obolibrary.org/obo/UBERON_0003281	mesentery of stomach	http://purl.obolibrary.org/obo/UBERON_0004854	gastrointestinal system mesentery		The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum.
http://purl.obolibrary.org/obo/UBERON_0003282	mesentery of heart	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		A mesentery that surrounds the heart.
http://purl.obolibrary.org/obo/UBERON_0003283	mesentery of oesophagus	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		A mesentery that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003284	mesentery of midgut	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		A mesentery that is part of a midgut [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003288	meninx of midbrain	http://purl.obolibrary.org/obo/UBERON_0003547	brain meninx		A meninx that is part of a midbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003289	meninx of telencephalon	http://purl.obolibrary.org/obo/UBERON_0003548	forebrain meninges		A meninx that is part of a telencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003290	meninx of diencephalon	http://purl.obolibrary.org/obo/UBERON_0003548	forebrain meninges		A meninx that is part of a diencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003291	meninx of hindbrain	http://purl.obolibrary.org/obo/UBERON_0003547	brain meninx		A meninx that is part of a hindbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003294	gland of foregut	http://purl.obolibrary.org/obo/UBERON_0003408	gland of digestive tract		A gland that is part of a foregut [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003295	pharyngeal gland	http://purl.obolibrary.org/obo/UBERON_0036225	respiratory system gland		Racemose mucous glands beneath the mucous membrane of the pharynx.
http://purl.obolibrary.org/obo/UBERON_0003296	gland of diencephalon	http://purl.obolibrary.org/obo/UBERON_0002530	gland		Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis.
http://purl.obolibrary.org/obo/UBERON_0003297	gland of integumental system	http://purl.obolibrary.org/obo/UBERON_0002530	gland		A gland that is part of a integumental system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003299	roof plate of midbrain	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The mesencephalic roof plate, including the caudal and rostral part of the midbrain roof.
http://purl.obolibrary.org/obo/UBERON_0003300	roof plate of telencephalon	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		A roof plate that is part of a telencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003301	roof plate of diencephalon	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		A roof plate that is part of a diencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003302	roof plate of metencephalon	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		A roof plate that is part of a metencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003303	roof plate of medulla oblongata	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		A roof plate that is part of a medulla oblongata [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003304	mesoderm blood island	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		A blood island that is part of a mesoderm.
http://purl.obolibrary.org/obo/UBERON_0003312	mesenchyme of testis	http://purl.obolibrary.org/obo/UBERON_0003855	gonad mesenchyme		Mesenchyme that is part of a developing testis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003314	eye mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009891	facial mesenchyme		Mesenchyme that is part of a developing camera-type eye.
http://purl.obolibrary.org/obo/UBERON_0003315	mesenchyme of ovary	http://purl.obolibrary.org/obo/UBERON_0003855	gonad mesenchyme		Mesenchyme that is part of a developing ovary [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003316	mesenchyme of yolk sac	http://purl.obolibrary.org/obo/UBERON_0010333	extraembryonic membrane mesenchyme		The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0003317	odontogenic papilla of incisor	http://purl.obolibrary.org/obo/UBERON_0001763	odontogenic papilla		An odontogenic papilla that is part of a incisor tooth [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003318	mesenchyme of elbow	http://purl.obolibrary.org/obo/UBERON_0003859	forelimb mesenchyme		Mesenchyme that is part of a developing elbow [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003319	mesenchyme of carpal region	http://purl.obolibrary.org/obo/UBERON_0003859	forelimb mesenchyme		Mesenchyme of the carpal region that contributes to the carpal skeleton.
http://purl.obolibrary.org/obo/UBERON_0003320	mesenchyme of hip	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a developing hip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003321	mesenchyme of knee	http://purl.obolibrary.org/obo/UBERON_0003860	hindlimb mesenchyme		Mesenchyme that is part of a developing knee [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003322	mesenchyme of shoulder	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a developing shoulder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003323	mesenchyme of upper jaw	http://purl.obolibrary.org/obo/UBERON_0034995	jaw mesenchyme		Mesenchyme that is part of a developing upper jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003324	mesenchyme of lower jaw	http://purl.obolibrary.org/obo/UBERON_0034995	jaw mesenchyme		Mesenchyme that is part of a developing lower jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003325	mesenchyme of pinna	http://purl.obolibrary.org/obo/UBERON_0005253	head mesenchyme		Mesenchyme that is part of a developing pinna [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003326	mesenchyme of mammary gland	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a developing mammary gland.
http://purl.obolibrary.org/obo/UBERON_0003327	mesenchyme of forearm	http://purl.obolibrary.org/obo/UBERON_0003859	forelimb mesenchyme		Mesenchyme that is part of a developing lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003328	mesenchyme of footplate	http://purl.obolibrary.org/obo/UBERON_0010377	mesenchyme from somatopleure		Mesenchyme that is part of a footplate.
http://purl.obolibrary.org/obo/UBERON_0003329	submucosa of anal canal	http://purl.obolibrary.org/obo/UBERON_0001208	submucosa of large intestine		A submucosa that is part of an anal canal [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003330	submucosa of rectum	http://purl.obolibrary.org/obo/UBERON_0001208	submucosa of large intestine		The submucous layer of the wall of the rectum.
http://purl.obolibrary.org/obo/UBERON_0003331	submucosa of colon	http://purl.obolibrary.org/obo/UBERON_0001208	submucosa of large intestine		A submucosa that is part of a colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003332	submucosa of duodenum	http://purl.obolibrary.org/obo/UBERON_0001205	submucosa of small intestine		A submucosa that is part of a duodenum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003333	submucosa of jejunum	http://purl.obolibrary.org/obo/UBERON_0001205	submucosa of small intestine		A submucosa that is part of a jejunum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003334	serosa of rectum	http://purl.obolibrary.org/obo/UBERON_0001209	serosa of large intestine		A serous membrane that is part of a rectum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003335	serosa of colon	http://purl.obolibrary.org/obo/UBERON_0001209	serosa of large intestine		A serous membrane that is part of a colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003336	serosa of duodenum	http://purl.obolibrary.org/obo/UBERON_0001206	serosa of small intestine		A serous membrane that is part of a duodenum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003337	serosa of jejunum	http://purl.obolibrary.org/obo/UBERON_0001206	serosa of small intestine		A serous membrane that is part of a jejunum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003338	ganglion of peripheral nervous system	http://purl.obolibrary.org/obo/UBERON_0000045	ganglion		A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO).
http://purl.obolibrary.org/obo/UBERON_0003339	ganglion of central nervous system	http://purl.obolibrary.org/obo/UBERON_0000045	ganglion		A ganglion that is part of a central nervous system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003342	mucosa of anal canal	http://purl.obolibrary.org/obo/UBERON_0001207	mucosa of large intestine		A mucosa that is part of an anal canal [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003343	mucosa of oral region	http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa		A mucosa that is part of a oral opening [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003346	mucosa of rectum	http://purl.obolibrary.org/obo/UBERON_0001207	mucosa of large intestine		A mucosa that is part of a rectum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003350	epithelium of mucosa	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		A layer of epithelial cells on the surface of the mucosa.
http://purl.obolibrary.org/obo/UBERON_0003351	pharyngeal epithelium	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An epithelium that is part of a pharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003352	epithelium of midgut	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		An epithelium that is part of a midgut.
http://purl.obolibrary.org/obo/UBERON_0003353	epithelium of hindgut	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		An epithelium that is part of a hindgut [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003354	epithelium of rectum	http://purl.obolibrary.org/obo/UBERON_0016885	epithelium of terminal part of digestive tract		An epithelium that is part of a rectum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003355	epithelium of incisor	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a incisor tooth [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003356	epithelium of nasal septum	http://purl.obolibrary.org/obo/UBERON_0019306	nose epithelium		An epithelium that is part of a nasal septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003357	epithelium of tongue	http://purl.obolibrary.org/obo/UBERON_0019304	sensory organ epithelium		An epithelium that is part of a tongue [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003358	epithelium of soft palate	http://purl.obolibrary.org/obo/UBERON_0003235	epithelium of upper jaw		An epithelium that is part of a soft palate [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003359	epithelium of submandibular gland	http://purl.obolibrary.org/obo/UBERON_0004809	salivary gland epithelium		An epithelium that is part of a submandibular gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003360	epithelium of parotid gland	http://purl.obolibrary.org/obo/UBERON_0004809	salivary gland epithelium		An epithelium that is part of a parotid gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003361	epithelium of sublingual gland	http://purl.obolibrary.org/obo/UBERON_0004809	salivary gland epithelium		An epithelium that is part of a sublingual gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003364	epithelium of right lung	http://purl.obolibrary.org/obo/UBERON_0000115	lung epithelium		An epithelium that is part of a right lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003365	epithelium of left lung	http://purl.obolibrary.org/obo/UBERON_0000115	lung epithelium		An epithelium that is part of a left lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003368	epithelium of hard palate	http://purl.obolibrary.org/obo/UBERON_0003235	epithelium of upper jaw		An epithelium that is part of a hard palate [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003371	pelvic appendage bud ectoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An unilaminar epithelium that surrounds a pelvic appendage bud.
http://purl.obolibrary.org/obo/UBERON_0003372	pectoral appendage bud ectoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An unilaminar epithelium that surrounds a pectoral appendage bud.
http://purl.obolibrary.org/obo/UBERON_0003373	ectoderm of footplate	http://purl.obolibrary.org/obo/UBERON_0000924	ectoderm		An ectoderm that is part of a footplate.
http://purl.obolibrary.org/obo/UBERON_0003374	chorionic ectoderm	http://purl.obolibrary.org/obo/UBERON_0000478	extraembryonic structure		An extraembryonic structure that develops_from a ectoderm and is part of a chorion.
http://purl.obolibrary.org/obo/UBERON_0003379	cardiac muscle of right atrium	http://purl.obolibrary.org/obo/UBERON_0004490	cardiac muscle tissue of atrium		A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003380	cardiac muscle of left atrium	http://purl.obolibrary.org/obo/UBERON_0004490	cardiac muscle tissue of atrium		A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003381	cardiac muscle of right ventricle	http://purl.obolibrary.org/obo/UBERON_0018649	cardiac muscle tissue of ventricle		A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003382	cardiac muscle of left ventricle	http://purl.obolibrary.org/obo/UBERON_0018649	cardiac muscle tissue of ventricle		A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003383	cardiac muscle tissue of interventricular septum	http://purl.obolibrary.org/obo/UBERON_0004667	interventricular septum muscular part		A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003384	skeletal muscle tissue of pharynx	http://purl.obolibrary.org/obo/UBERON_0004830	respiratory system skeletal muscle		A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003386	smooth muscle of eye	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi.
http://purl.obolibrary.org/obo/UBERON_0003387	smooth muscle of trachea	http://purl.obolibrary.org/obo/UBERON_0004233	lower respiratory tract smooth muscle		A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003388	mesothelium of pericardial cavity	http://purl.obolibrary.org/obo/UBERON_0001136	mesothelium		A mesothelium that is part of a pericardium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003389	mesothelium of diaphragm	http://purl.obolibrary.org/obo/UBERON_0004807	respiratory system epithelium		A mesothelium that is part of a diaphragm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003390	mesothelium of pleural cavity	http://purl.obolibrary.org/obo/UBERON_0001136	mesothelium		A mesothelium that is part of a pleural cavity [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003393	mesentery of urinary system	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		A mesentery that is part of a urinary system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003394	mesentery of hindgut	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		A mesentery that is part of a hindgut [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003395	mesentery of rectum	http://purl.obolibrary.org/obo/UBERON_0004854	gastrointestinal system mesentery		A mesentery that is part of a rectum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003396	mesentery of colon	http://purl.obolibrary.org/obo/UBERON_0007826	peritoneal mesentery		A mesentery that is part of a colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003397	mesentery of duodenum	http://purl.obolibrary.org/obo/UBERON_0003336	serosa of duodenum		A mesentery that is part of a duodenum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003398	mesentery of jejunum	http://purl.obolibrary.org/obo/UBERON_0003337	serosa of jejunum		A mesentery that is part of a jejunum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003403	skin of forearm	http://purl.obolibrary.org/obo/UBERON_0002427	arm skin		A zone of skin that is part of a lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003406	cartilage of respiratory system	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		A cartilage element that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003407	cartilage of nasal septum	http://purl.obolibrary.org/obo/UBERON_0003932	cartilage element of chondrocranium		A cartilage that is part of a nasal septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003408	gland of digestive tract	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A gland that is part of a digestive tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003409	gland of tongue	http://purl.obolibrary.org/obo/UBERON_0010047	oral gland		Any of the mucous, serous, or mixed glands that empty their secretions onto the surface of the tongue.
http://purl.obolibrary.org/obo/UBERON_0003412	pelvic appendage bud mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010329	paired limb/fin bud mesenchyme		Mesenchyme that is part of a pelvic appendage bud.
http://purl.obolibrary.org/obo/UBERON_0003413	pectoral appendage bud mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010329	paired limb/fin bud mesenchyme		Mesenchyme that is part of a pectoral appendage bud.
http://purl.obolibrary.org/obo/UBERON_0003414	mesenchyme of mandible	http://purl.obolibrary.org/obo/UBERON_0009891	facial mesenchyme		Mesenchyme that is part of a developing mandible [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003415	mesenchyme of nasal septum	http://purl.obolibrary.org/obo/UBERON_0009891	facial mesenchyme		Mesenchyme that is part of a developing nasal septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003416	mesenchyme of tongue	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a developing tongue [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003417	mesenchyme of soft palate	http://purl.obolibrary.org/obo/UBERON_0003323	mesenchyme of upper jaw		Mesenchyme that is part of a developing soft palate [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003418	mesenchyme of submandibular gland	http://purl.obolibrary.org/obo/UBERON_0003324	mesenchyme of lower jaw		Mesenchyme that is part of a developing submandibular gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003419	mesenchyme of parotid	http://purl.obolibrary.org/obo/UBERON_0009891	facial mesenchyme		Mesenchyme that is part of a developing parotid gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003420	mesenchyme of sublingual gland	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a developing sublingual gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003422	mesenchyme of umbilical cord	http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue		A gelatinous substance within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It also contains some fibroblasts and macrophages. It is derived from Extra Embryonic Mesoderm[WP].
http://purl.obolibrary.org/obo/UBERON_0003424	mesenchyme of hard palate	http://purl.obolibrary.org/obo/UBERON_0003323	mesenchyme of upper jaw		Mesenchyme that is part of a developing hard palate [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003425	renal lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is located in a kidney [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003426	dermis adipose tissue	http://purl.obolibrary.org/obo/UBERON_0003585	dermis connective tissue		An adipose tissue that is part of a dermis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003427	abdominal fat pad	http://purl.obolibrary.org/obo/UBERON_0007808	adipose tissue of abdominal region		The encapsulated adipose tissue in the abdomen.
http://purl.obolibrary.org/obo/UBERON_0003428	gonadal fat pad	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The encapsulated adipose tissue associated with the ovaries or testes.
http://purl.obolibrary.org/obo/UBERON_0003429	abdomen nerve	http://purl.obolibrary.org/obo/UBERON_0003825	nerve of abdominal segment		A nerve that is part of an abdomen [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003430	neck nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is part of a neck [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003431	leg nerve	http://purl.obolibrary.org/obo/UBERON_0003442	hindlimb nerve		A nerve that is part of a leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003432	chest nerve	http://purl.obolibrary.org/obo/UBERON_0003824	nerve of thoracic segment		A nerve that is part of a chest [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003433	arm nerve	http://purl.obolibrary.org/obo/UBERON_0003441	forelimb nerve		A nerve that is part of an arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003434	wrist nerve	http://purl.obolibrary.org/obo/UBERON_0003448	manus nerve		A nerve that is part of a wrist [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003435	pedal digit nerve	http://purl.obolibrary.org/obo/UBERON_0003445	pes nerve		A nerve that is part of a toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003436	shoulder nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is part of a shoulder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003437	eyelid nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that innervates an eyelid.
http://purl.obolibrary.org/obo/UBERON_0003438	iris nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		Any nerve that innervates the iris.
http://purl.obolibrary.org/obo/UBERON_0003439	nerve of trunk region	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk).
http://purl.obolibrary.org/obo/UBERON_0003440	limb nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003441	forelimb nerve	http://purl.obolibrary.org/obo/UBERON_0003440	limb nerve		A nerve that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003442	hindlimb nerve	http://purl.obolibrary.org/obo/UBERON_0003440	limb nerve		A nerve that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003443	thoracic cavity nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is located in a thoracic cavity [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003444	pelvis nerve	http://purl.obolibrary.org/obo/UBERON_0003825	nerve of abdominal segment		A nerve that is part of a pelvis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003445	pes nerve	http://purl.obolibrary.org/obo/UBERON_0003442	hindlimb nerve		A nerve that is part of a foot [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003446	ankle nerve	http://purl.obolibrary.org/obo/UBERON_0003445	pes nerve		A nerve that is part of an ankle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003447	digit nerve of manus	http://purl.obolibrary.org/obo/UBERON_0003448	manus nerve		A nerve that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003448	manus nerve	http://purl.obolibrary.org/obo/UBERON_0003441	forelimb nerve		A nerve that is part of a manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003449	tail intervertebral disc	http://purl.obolibrary.org/obo/UBERON_0001066	intervertebral disk		An intervertebral disk that is part of a tail [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003450	upper jaw incisor	http://purl.obolibrary.org/obo/UBERON_2001626	premaxillary tooth		An incisor tooth that is part of a upper jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003451	lower jaw incisor	http://purl.obolibrary.org/obo/UBERON_0003268	tooth of lower jaw		An incisor tooth that is part of a lower jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003456	respiratory system lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		A lymphatic vessel that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003457	head bone	http://purl.obolibrary.org/obo/UBERON_0007914	bone of craniocervical region		A bone that is part of a head [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003458	neck bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		A bone that is part of a neck [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003459	chest bone	http://purl.obolibrary.org/obo/UBERON_0005175	chest organ		A bone that is part of a chest [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003460	arm bone	http://purl.obolibrary.org/obo/UBERON_0008962	forelimb bone		A bone that is part of the region of the forelimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia.
http://purl.obolibrary.org/obo/UBERON_0003461	shoulder bone	http://purl.obolibrary.org/obo/UBERON_0010741	bone of pectoral complex		A bone that is connected via a shoulder joint (i.e. glenohumeral or acromioclavicular joints). The shoulder bones are the clavicle, scapula and humerus - but note that these are only considered to be shoulder bones when a true shoulder is present, as in most tetrapods.
http://purl.obolibrary.org/obo/UBERON_0003462	facial bone	http://purl.obolibrary.org/obo/UBERON_0003457	head bone		A bone that is part of a facial skeleton [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003463	trunk bone	http://purl.obolibrary.org/obo/UBERON_0005177	trunk region element		A bone that is part of a trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003464	hindlimb bone	http://purl.obolibrary.org/obo/UBERON_0015022	hindlimb endochondral element		A bone that is part of a hindlimb region. Examples: any pes phalanx, femur. Counter-examples: ischium, pubis (they are part of the pelvic girdle).
http://purl.obolibrary.org/obo/UBERON_0003466	forelimb zeugopod bone	http://purl.obolibrary.org/obo/UBERON_0003460	arm bone		A bone that is part of a lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003468	ureteric segment of renal artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		The ureteral branches of renal artery are small branches which supply the ureter.
http://purl.obolibrary.org/obo/UBERON_0003469	respiratory system artery	http://purl.obolibrary.org/obo/UBERON_0003643	respiratory system arterial blood vessel		An artery that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003470	artery of upper lip	http://purl.obolibrary.org/obo/UBERON_0009657	artery of lip		The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose.
http://purl.obolibrary.org/obo/UBERON_0003471	artery of lower lip	http://purl.obolibrary.org/obo/UBERON_0009657	artery of lip		The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery.
http://purl.obolibrary.org/obo/UBERON_0003472	cerebellar artery	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		An artery that supplies blood to the cerebellum.
http://purl.obolibrary.org/obo/UBERON_0003473	thoracic cavity artery	http://purl.obolibrary.org/obo/UBERON_0003519	thoracic cavity blood vessel		An artery that is part of a thoracic cavity[cjm].
http://purl.obolibrary.org/obo/UBERON_0003474	meningeal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		One of the arteries supplying a meninix[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003475	ureteric vein	http://purl.obolibrary.org/obo/UBERON_0003520	pelvis blood vessel		A vein that is part of a ureter [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003476	respiratory system venous blood vessel	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003477	vein of upper lip	http://purl.obolibrary.org/obo/UBERON_0013136	vein of lip		The inferior labial vein is the vein receiving blood from the upper lip.
http://purl.obolibrary.org/obo/UBERON_0003478	vein of lower lip	http://purl.obolibrary.org/obo/UBERON_0013136	vein of lip		The inferior labial vein is the vein receiving blood from the lower lip.
http://purl.obolibrary.org/obo/UBERON_0003479	thoracic cavity vein	http://purl.obolibrary.org/obo/UBERON_0003519	thoracic cavity blood vessel		A vein that is part of a thoracic cavity [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003480	vein of clitoris	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A vein that is part of a clitoris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003481	tail vein	http://purl.obolibrary.org/obo/UBERON_0003524	tail blood vessel		A vein that is part of a tail [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003482	vein of trabecular bone	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		A portion of vein that is part of a trabecular bone tissue [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003483	thymus lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0001744	lymphoid tissue		A portion of lymphoid tissue that is part of a thymus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003484	eye sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0003605	eye skin gland		A sebaceous gland that is part of a camera-type eye. Example: a tarsal gland.
http://purl.obolibrary.org/obo/UBERON_0003485	vagina sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0005398	female reproductive gland		A sebaceous gland that is part of a vagina [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003487	skin sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0001821	sebaceous gland		A holocrine gland of the dermis that secretes sebum into hair follicles.
http://purl.obolibrary.org/obo/UBERON_0003488	abdominal mammary gland	http://purl.obolibrary.org/obo/UBERON_0005172	abdomen element		A lactiferous gland that is part of the abdominal region [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003489	respiratory system capillary endothelium	http://purl.obolibrary.org/obo/UBERON_0004702	respiratory system blood vessel endothelium		An endothelium of capillary that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003494	respiratory system venule	http://purl.obolibrary.org/obo/UBERON_0003504	respiratory system blood vessel		A venule that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003495	respiratory system arteriole	http://purl.obolibrary.org/obo/UBERON_0003643	respiratory system arterial blood vessel		An arteriole that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a head [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003497	abdomen blood vessel	http://purl.obolibrary.org/obo/UBERON_0003835	abdominal segment blood vessel		A blood vessel that is part of an abdomen [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003498	heart blood vessel	http://purl.obolibrary.org/obo/UBERON_0005985	coronary vessel		A blood vessel that is part of a heart [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003499	brain blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a brain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003500	corneal blood vessel	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A blood vessel that is part of a cornea [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003501	retina blood vessel	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A blood vessel that is part of a retina [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003502	neck blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a neck [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003503	leg blood vessel	http://purl.obolibrary.org/obo/UBERON_0003516	hindlimb blood vessel		A blood vessel that is part of a leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003504	respiratory system blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003505	trachea blood vessel	http://purl.obolibrary.org/obo/UBERON_0003504	respiratory system blood vessel		A blood vessel that is part of a trachea.
http://purl.obolibrary.org/obo/UBERON_0003506	chest blood vessel	http://purl.obolibrary.org/obo/UBERON_0003834	thoracic segment blood vessel		A blood vessel that is part of a chest [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003507	arm blood vessel	http://purl.obolibrary.org/obo/UBERON_0003515	forelimb blood vessel		A blood vessel that is part of an arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003508	pedal digit blood vessel	http://purl.obolibrary.org/obo/UBERON_0003521	pes blood vessel		A blood vessel that is part of a toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003509	arterial blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.
http://purl.obolibrary.org/obo/UBERON_0003510	eyelid blood vessel	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A blood vessel that is part of a eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003511	iris blood vessel	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A blood vessel that is part of a iris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003512	lung blood vessel	http://purl.obolibrary.org/obo/UBERON_0003834	thoracic segment blood vessel		A blood vessel that is part of a lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003513	trunk blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003514	limb blood vessel	http://purl.obolibrary.org/obo/UBERON_0007301	appendage blood vessel		A blood vessel that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003515	forelimb blood vessel	http://purl.obolibrary.org/obo/UBERON_0007300	pectoral appendage blood vessel		A blood vessel that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003516	hindlimb blood vessel	http://purl.obolibrary.org/obo/UBERON_0003514	limb blood vessel		A blood vessel that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003517	kidney blood vessel	http://purl.obolibrary.org/obo/UBERON_0003497	abdomen blood vessel		A blood vessel that is part of a kidney [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003519	thoracic cavity blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a thoracic cavity [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003520	pelvis blood vessel	http://purl.obolibrary.org/obo/UBERON_0003835	abdominal segment blood vessel		A blood vessel that is part of a pelvis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003521	pes blood vessel	http://purl.obolibrary.org/obo/UBERON_0003516	hindlimb blood vessel		A blood vessel that is part of a foot [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003522	manual digit blood vessel	http://purl.obolibrary.org/obo/UBERON_0003523	manus blood vessel		A blood vessel that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003523	manus blood vessel	http://purl.obolibrary.org/obo/UBERON_0003515	forelimb blood vessel		A blood vessel that is part of a manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003524	tail blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a tail [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003526	respiratory system capillary	http://purl.obolibrary.org/obo/UBERON_0003504	respiratory system blood vessel		A capillary that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003527	kidney capillary	http://purl.obolibrary.org/obo/UBERON_0003517	kidney blood vessel		A capillary that is part of a kidney [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003528	brain gray matter	http://purl.obolibrary.org/obo/UBERON_0002020	gray matter		A gray matter that is part of a brain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003529	respiratory system lymphatic vessel endothelium	http://purl.obolibrary.org/obo/UBERON_0004807	respiratory system epithelium		An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003530	pedal digit skin	http://purl.obolibrary.org/obo/UBERON_0015249	digit skin		A zone of skin that is part of a toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003531	forelimb skin	http://purl.obolibrary.org/obo/UBERON_0001419	skin of limb		A zone of skin that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003532	hindlimb skin	http://purl.obolibrary.org/obo/UBERON_0001419	skin of limb		A zone of skin that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003533	manual digit skin	http://purl.obolibrary.org/obo/UBERON_0015249	digit skin		A zone of skin that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003534	tail skin	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is part of a tail [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003535	vagus X nerve trunk	http://purl.obolibrary.org/obo/UBERON_0002464	nerve trunk		A nerve trunk that is part of a vagus nerve.
http://purl.obolibrary.org/obo/UBERON_0003536	right lung alveolar duct	http://purl.obolibrary.org/obo/UBERON_0002173	pulmonary alveolar duct		An alveolar duct that is part of a right lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003537	left lung alveolar duct	http://purl.obolibrary.org/obo/UBERON_0002173	pulmonary alveolar duct		An alveolar duct that is part of a left lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003538	right lung bronchiole	http://purl.obolibrary.org/obo/UBERON_0002186	bronchiole		A bronchiole that is part of a right lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003539	left lung bronchiole	http://purl.obolibrary.org/obo/UBERON_0002186	bronchiole		A bronchiole that is part of a left lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003540	right lung terminal bronchiole	http://purl.obolibrary.org/obo/UBERON_0003538	right lung bronchiole		A terminal bronchiole that is part of a right lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003541	left lung terminal bronchiole	http://purl.obolibrary.org/obo/UBERON_0003539	left lung bronchiole		A terminal bronchiole that is part of a left lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003542	right lung respiratory bronchiole	http://purl.obolibrary.org/obo/UBERON_0003538	right lung bronchiole		A respiratory bronchiole that is part of a right lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003543	left lung respiratory bronchiole	http://purl.obolibrary.org/obo/UBERON_0003539	left lung bronchiole		A respiratory bronchiole that is part of a left lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003544	brain white matter	http://purl.obolibrary.org/obo/UBERON_0002316	white matter		The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.
http://purl.obolibrary.org/obo/UBERON_0003547	brain meninx	http://purl.obolibrary.org/obo/UBERON_0002360	meninx		A meninx that is part of a brain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003548	forebrain meninges	http://purl.obolibrary.org/obo/UBERON_0003547	brain meninx		A meninx that is part of a forebrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003549	brain pia mater	http://purl.obolibrary.org/obo/UBERON_0003547	brain meninx		The fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule.
http://purl.obolibrary.org/obo/UBERON_0003550	forebrain pia mater	http://purl.obolibrary.org/obo/UBERON_0003549	brain pia mater		A pia mater that is part of a forebrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003551	midbrain pia mater	http://purl.obolibrary.org/obo/UBERON_0003549	brain pia mater		A pia mater that is part of a midbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003552	telencephalon pia mater	http://purl.obolibrary.org/obo/UBERON_0003550	forebrain pia mater		A pia mater that is part of a telencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003553	diencephalon pia mater	http://purl.obolibrary.org/obo/UBERON_0003550	forebrain pia mater		A pia mater that is part of a diencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003554	hindbrain pia mater	http://purl.obolibrary.org/obo/UBERON_0003549	brain pia mater		A pia mater that is part of a hindbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003555	spinal cord pia mater	http://purl.obolibrary.org/obo/UBERON_0002361	pia mater		A pia mater that is part of a spinal cord [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003556	forebrain arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0003548	forebrain meninges		An arachnoid mater that is part of a forebrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003557	midbrain arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0003288	meninx of midbrain		An arachnoid mater that is part of a midbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003558	diencephalon arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0003556	forebrain arachnoid mater		An arachnoid mater that is part of a diencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003559	hindbrain arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0003291	meninx of hindbrain		An arachnoid mater that is part of a hindbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003560	spinal cord arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0002362	arachnoid mater		An arachnoid mater that is part of a spinal cord [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003561	forebrain dura mater	http://purl.obolibrary.org/obo/UBERON_0003548	forebrain meninges		A dura mater that is part of a forebrain.
http://purl.obolibrary.org/obo/UBERON_0003562	midbrain dura mater	http://purl.obolibrary.org/obo/UBERON_0003288	meninx of midbrain		A dura mater that is part of a midbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003563	telencephalon dura mater	http://purl.obolibrary.org/obo/UBERON_0003561	forebrain dura mater		A dura mater that is part of a telencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003564	diencephalon dura mater	http://purl.obolibrary.org/obo/UBERON_0003561	forebrain dura mater		A dura mater that is part of a diencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003565	hindbrain dura mater	http://purl.obolibrary.org/obo/UBERON_0003291	meninx of hindbrain		A dura mater that is part of a hindbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003566	head connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a head [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003567	abdomen connective tissue	http://purl.obolibrary.org/obo/UBERON_0003838	abdominal segment connective tissue		A portion of connective tissue that is part of an abdomen [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003568	neck connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a neck [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003569	leg connective tissue	http://purl.obolibrary.org/obo/UBERON_0003589	hindlimb connective tissue		A portion of connective tissue that is part of a leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003570	respiratory system connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003571	trachea connective tissue	http://purl.obolibrary.org/obo/UBERON_0003580	lower respiratory tract connective tissue		A portion of connective tissue that is part of a trachea.
http://purl.obolibrary.org/obo/UBERON_0003572	chest connective tissue	http://purl.obolibrary.org/obo/UBERON_0003837	thoracic segment connective tissue		A portion of connective tissue that is part of a chest [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003573	arm connective tissue	http://purl.obolibrary.org/obo/UBERON_0003588	forelimb connective tissue		A portion of connective tissue that is part of an arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003574	elbow connective tissue	http://purl.obolibrary.org/obo/UBERON_0003573	arm connective tissue		A portion of connective tissue that is part of a elbow [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003575	wrist connective tissue	http://purl.obolibrary.org/obo/UBERON_0003598	manus connective tissue		A portion of connective tissue that is part of a wrist [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003576	hip connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a hip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003577	knee connective tissue	http://purl.obolibrary.org/obo/UBERON_0003569	leg connective tissue		A portion of connective tissue that is part of a knee [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003578	pedal digit connective tissue	http://purl.obolibrary.org/obo/UBERON_0015791	digit connective tissue		A portion of connective tissue that is part of a toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003579	shoulder connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a shoulder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003580	lower respiratory tract connective tissue	http://purl.obolibrary.org/obo/UBERON_0003570	respiratory system connective tissue		A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003581	eyelid connective tissue	http://purl.obolibrary.org/obo/UBERON_0003566	head connective tissue		A portion of connective tissue that is part of a eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003582	nasopharynx connective tissue	http://purl.obolibrary.org/obo/UBERON_0003570	respiratory system connective tissue		A portion of connective tissue that is part of a nasopharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003583	larynx connective tissue	http://purl.obolibrary.org/obo/UBERON_0003570	respiratory system connective tissue		A portion of connective tissue that is part of a larynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003584	mammary gland connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		The fibrous supportive tissue of the mammary gland.
http://purl.obolibrary.org/obo/UBERON_0003585	dermis connective tissue	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		A portion of connective tissue that is part of a dermis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003586	trunk connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003587	limb connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003588	forelimb connective tissue	http://purl.obolibrary.org/obo/UBERON_0003587	limb connective tissue		A portion of connective tissue that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003589	hindlimb connective tissue	http://purl.obolibrary.org/obo/UBERON_0003587	limb connective tissue		A portion of connective tissue that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003592	bronchus connective tissue	http://purl.obolibrary.org/obo/UBERON_0003580	lower respiratory tract connective tissue		A portion of connective tissue that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003593	thoracic cavity connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003594	pelvis connective tissue	http://purl.obolibrary.org/obo/UBERON_0003838	abdominal segment connective tissue		A portion of connective tissue that is part of a pelvis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003595	pes connective tissue	http://purl.obolibrary.org/obo/UBERON_0003589	hindlimb connective tissue		A portion of connective tissue that is part of a foot [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003596	ankle connective tissue	http://purl.obolibrary.org/obo/UBERON_0003595	pes connective tissue		A portion of connective tissue that is part of an ankle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003597	manual digit connective tissue	http://purl.obolibrary.org/obo/UBERON_0015791	digit connective tissue		A portion of connective tissue that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003598	manus connective tissue	http://purl.obolibrary.org/obo/UBERON_0003588	forelimb connective tissue		A portion of connective tissue that is part of a hand [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003599	tail connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a tail [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003601	neck cartilage	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		A cartilage that is part of a neck [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003603	lower respiratory tract cartilage	http://purl.obolibrary.org/obo/UBERON_0003406	cartilage of respiratory system		A cartilage that is part of a lower respiratory tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003604	trachea cartilage	http://purl.obolibrary.org/obo/UBERON_0003603	lower respiratory tract cartilage		The ring-shaped cartilaginous structures that support the trachea.
http://purl.obolibrary.org/obo/UBERON_0003605	eye skin gland	http://purl.obolibrary.org/obo/UBERON_0015152	gland of ocular region		A skin gland that is part of a camera-type eye [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003606	limb long bone	http://purl.obolibrary.org/obo/UBERON_0002428	limb bone		A long bone that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003607	forelimb long bone	http://purl.obolibrary.org/obo/UBERON_0008962	forelimb bone		A long bone that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003608	hindlimb long bone	http://purl.obolibrary.org/obo/UBERON_0003606	limb long bone		A long bone that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003609	aorta elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003614	blood vessel elastic tissue		The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall.
http://purl.obolibrary.org/obo/UBERON_0003610	heart elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003837	thoracic segment connective tissue		The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers.
http://purl.obolibrary.org/obo/UBERON_0003611	respiratory system elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003570	respiratory system connective tissue		An elastic tissue that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003613	cardiovascular system elastic tissue	http://purl.obolibrary.org/obo/UBERON_0002521	elastic tissue		An elastic tissue that is part of a circulatory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003614	blood vessel elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003613	cardiovascular system elastic tissue		Elastic tissue layer that lines a blood vessel layer.
http://purl.obolibrary.org/obo/UBERON_0003615	lung elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003611	respiratory system elastic tissue		Elastic tissue that is part of a lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003616	bronchus elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003611	respiratory system elastic tissue		An elastic tissue that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003617	trachea elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003611	respiratory system elastic tissue		An elastic tissue that is part of a trachea [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003618	aorta tunica media	http://purl.obolibrary.org/obo/UBERON_0002522	tunica media		The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers.
http://purl.obolibrary.org/obo/UBERON_0003619	aorta tunica intima	http://purl.obolibrary.org/obo/UBERON_0004797	blood vessel layer		The innermost layer of the aorta, containing the endothelium and an inner elastic membrane.
http://purl.obolibrary.org/obo/UBERON_0003620	manual digit 1 phalanx	http://purl.obolibrary.org/obo/UBERON_0015025	manual digit 1 phalanx endochondral element		A phalanx that is part of a hand digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003622	manual digit 2	http://purl.obolibrary.org/obo/UBERON_0019232	manual digit 2, 3 or 4		2nd digit of the manus.
http://purl.obolibrary.org/obo/UBERON_0003623	manual digit 3	http://purl.obolibrary.org/obo/UBERON_0019232	manual digit 2, 3 or 4		3rd digit of the manus.
http://purl.obolibrary.org/obo/UBERON_0003624	manual digit 4	http://purl.obolibrary.org/obo/UBERON_0019232	manual digit 2, 3 or 4		4th digit of the manus.
http://purl.obolibrary.org/obo/UBERON_0003625	manual digit 5	http://purl.obolibrary.org/obo/UBERON_0019231	manual digit 1 or 5		5th digit of the manus.
http://purl.obolibrary.org/obo/UBERON_0003631	pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0019241	pedal digit 1 or 5		1st digit of the hind autopod.
http://purl.obolibrary.org/obo/UBERON_0003632	pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0019242	pedal digit 2, 3 or 4		2nd digit of the hind autopod.
http://purl.obolibrary.org/obo/UBERON_0003633	pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0019242	pedal digit 2, 3 or 4		3rd digit of the hind autopod.
http://purl.obolibrary.org/obo/UBERON_0003634	pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0019242	pedal digit 2, 3 or 4		4th digit of the hind autopod.
http://purl.obolibrary.org/obo/UBERON_0003635	pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0019241	pedal digit 1 or 5		5th digit of the hind autopod.
http://purl.obolibrary.org/obo/UBERON_0003636	manual digit 2 phalanx	http://purl.obolibrary.org/obo/UBERON_0015026	manual digit 2 phalanx endochondral element		A phalanx that is part of a hand digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003637	manual digit 3 phalanx	http://purl.obolibrary.org/obo/UBERON_0015027	manual digit 3 phalanx endochondral element		A phalanx that is part of a hand digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003638	manual digit 4 phalanx	http://purl.obolibrary.org/obo/UBERON_0015028	manual digit 4 phalanx endochondral element		A phalanx that is part of a hand digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003639	manual digit 5 phalanx	http://purl.obolibrary.org/obo/UBERON_0015029	manual digit 5 phalanx endochondral element		A phalanx that is part of a hand digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003640	pedal digit 1 phalanx	http://purl.obolibrary.org/obo/UBERON_0015031	pedal digit 1 phalanx endochondral element		A phalanx that is part of a foot digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003641	pedal digit 2 phalanx	http://purl.obolibrary.org/obo/UBERON_0015032	pedal digit 2 phalanx endochondral element		A phalanx that is part of a foot digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003642	pedal digit 3 phalanx	http://purl.obolibrary.org/obo/UBERON_0015033	pedal digit 3 phalanx endochondral element		A phalanx that is part of a foot digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003643	respiratory system arterial blood vessel	http://purl.obolibrary.org/obo/UBERON_0003509	arterial blood vessel		An arterial blood vessel that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003644	kidney arterial blood vessel	http://purl.obolibrary.org/obo/UBERON_0003517	kidney blood vessel		An arterial blood vessel that is part of a kidney [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003645	metacarpal bone of digit 1	http://purl.obolibrary.org/obo/UBERON_0015043	manual digit 1 metacarpus endochondral element		A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 1.
http://purl.obolibrary.org/obo/UBERON_0003646	metacarpal bone of digit 2	http://purl.obolibrary.org/obo/UBERON_0015044	manual digit 2 metacarpus endochondral element		A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 2.
http://purl.obolibrary.org/obo/UBERON_0003647	metacarpal bone of digit 3	http://purl.obolibrary.org/obo/UBERON_0015045	manual digit 3 metacarpus endochondral element		A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 3[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003648	metacarpal bone of digit 4	http://purl.obolibrary.org/obo/UBERON_0015046	manual digit 4 metacarpus endochondral element		A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 4.
http://purl.obolibrary.org/obo/UBERON_0003649	metacarpal bone of digit 5	http://purl.obolibrary.org/obo/UBERON_0015047	manual digit 5 metacarpus endochondral element		A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 5.
http://purl.obolibrary.org/obo/UBERON_0003650	metatarsal bone of digit 1	http://purl.obolibrary.org/obo/UBERON_0015037	pedal digit 1 metatarsal endochondral element		A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0003651	metatarsal bone of digit 2	http://purl.obolibrary.org/obo/UBERON_0015038	pedal digit 2 metatarsal endochondral element		A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 2.
http://purl.obolibrary.org/obo/UBERON_0003652	metatarsal bone of digit 3	http://purl.obolibrary.org/obo/UBERON_0015039	pedal digit 3 metatarsal endochondral element		A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 3[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003653	metatarsal bone of digit 4	http://purl.obolibrary.org/obo/UBERON_0015040	pedal digit 4 metatarsal endochondral element		A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 4.
http://purl.obolibrary.org/obo/UBERON_0003654	metatarsal bone of digit 5	http://purl.obolibrary.org/obo/UBERON_0015041	pedal digit 5 metatarsal endochondral element		A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0003655	molar tooth	http://purl.obolibrary.org/obo/UBERON_0013164	molariform tooth		Molars are the rearmost and most complicated kind of tooth in most mammals.
http://purl.obolibrary.org/obo/UBERON_0003656	mesopodium bone	http://purl.obolibrary.org/obo/UBERON_0013630	short bone		A bone that is part of a mesopodial skeleton.
http://purl.obolibrary.org/obo/UBERON_0003657	limb joint	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		Any joint that is part of a (free) limb.
http://purl.obolibrary.org/obo/UBERON_0003658	hip muscle	http://purl.obolibrary.org/obo/UBERON_0010890	pelvic complex muscle		Any muscle organ that is part of a hip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003659	pedal digit muscle	http://purl.obolibrary.org/obo/UBERON_0001498	muscle of pes		Any muscle organ that is part of a toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003660	eyelid muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		A muscle that attaches to an eyelid.
http://purl.obolibrary.org/obo/UBERON_0003661	limb muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Any muscle organ that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003662	forelimb muscle	http://purl.obolibrary.org/obo/UBERON_0014794	pectoral appendage muscle		Any muscle organ that is part of a forelimb.
http://purl.obolibrary.org/obo/UBERON_0003663	hindlimb muscle	http://purl.obolibrary.org/obo/UBERON_0014795	pelvic appendage muscle		Any muscle organ that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003664	manual digit muscle	http://purl.obolibrary.org/obo/UBERON_0001500	muscle of manus		Any muscle organ that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003665	post-anal tail muscle	http://purl.obolibrary.org/obo/UBERON_0004518	muscle of vertebral column		A muscle organ that attaches to a tail vertebra [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003666	upper jaw molar	http://purl.obolibrary.org/obo/UBERON_0011593	maxillary tooth		A molar tooth that is part of a upper jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003667	lower jaw molar	http://purl.obolibrary.org/obo/UBERON_0011594	dentary tooth		A molar tooth that is part of a lower jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003672	dentition	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		A collection of teeth arranged in some pattern in the mouth or other part of the body. The arrangement may be a simple row, a collection of rows, or a more elaborate structure, such as a toooth whorl.
http://purl.obolibrary.org/obo/UBERON_0003674	cuspid	http://purl.obolibrary.org/obo/UBERON_0001091	calcareous tooth		A tooth that is typically long and pointed and bearing a single cusp.
http://purl.obolibrary.org/obo/UBERON_0003675	tooth crown	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		The portion of the tooth covered by enamel.
http://purl.obolibrary.org/obo/UBERON_0003677	tooth root	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		The part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone.
http://purl.obolibrary.org/obo/UBERON_0003681	masticatory muscle	http://purl.obolibrary.org/obo/UBERON_0018544	trigeminal nerve muscle		In humans: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed).
http://purl.obolibrary.org/obo/UBERON_0003682	palatal muscle	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		The muscles of the palate are the glossopalatine, palatoglossus, levator palati(ni), musculus uvulae, palatopharyngeus, and tensor palati(ni).
http://purl.obolibrary.org/obo/UBERON_0003684	abdominal cavity	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity).
http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture	http://purl.obolibrary.org/obo/UBERON_0009198	craniofacial suture		Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture.
http://purl.obolibrary.org/obo/UBERON_0003689	sella turcica	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The sella turcica is a saddle-shaped depression in the sphenoid bone at the base of the human skull. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0003692	acromioclavicular joint	http://purl.obolibrary.org/obo/UBERON_0016884	shoulder joint		Any joint connecting the acromonion of the scapula and clavicle.
http://purl.obolibrary.org/obo/UBERON_0003694	atlanto-axial joint	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas.
http://purl.obolibrary.org/obo/UBERON_0003695	metacarpophalangeal joint	http://purl.obolibrary.org/obo/UBERON_0001489	manus joint		The metacarpophalangeal joints (MCP) are of the condyloid kind, formed by the reception of the rounded heads of the metacarpal bones into shallow cavities on the proximal ends of the first phalanges, with the exception of that of the thumb, which presents more of the characters of a ginglymoid joint. Arthritis of the MCP is a distinguishing feature of Rheumatoid Arthritis, as opposed to the distal interphalangeal joint in osteoarthritis. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0003696	metatarsophalangeal joint	http://purl.obolibrary.org/obo/UBERON_0001487	pes joint		The metatarsophalangeal articulations are the joints between the metatarsal bones of the foot and the proximal bones of the toes . They are condyloid joints meaning an elliptical or rounded surface (of the metatarsal bones) come close to the shallow cavities (of the proximal phalanges). The ligaments are the plantar and two collateral.
http://purl.obolibrary.org/obo/UBERON_0003697	abdominal wall	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles.
http://purl.obolibrary.org/obo/UBERON_0003698	subtalar joint	http://purl.obolibrary.org/obo/UBERON_0008447	intertarsal joint		A joint of the pes that connects the talus and the calcaneus.
http://purl.obolibrary.org/obo/UBERON_0003699	pubic symphysis	http://purl.obolibrary.org/obo/UBERON_0008114	joint of girdle		The firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones, which are united by an interpubic disc of fibrocartilage as well as the superior and arcuate pubic ligaments.
http://purl.obolibrary.org/obo/UBERON_0003700	temporomandibular joint	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A synovial joint of the jaw that connects the mandible to the temporal bone.
http://purl.obolibrary.org/obo/UBERON_0003701	calcaneal tendon	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		The Achilles tendon is a tendon of the posterior leg. It serves to attach the plantaris, gastrocnemius (calf) and soleus muscles to the calcaneus (heel) bone.
http://purl.obolibrary.org/obo/UBERON_0003702	inguinal canal	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		The passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively.
http://purl.obolibrary.org/obo/UBERON_0003706	laryngeal vocal fold	http://purl.obolibrary.org/obo/UBERON_0034681	vocal organ		Either of two pairs of folds of mucous membrane projecting into the larynx.
http://purl.obolibrary.org/obo/UBERON_0003707	sinus of Valsalva	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		One of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve.
http://purl.obolibrary.org/obo/UBERON_0003709	circle of Willis	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		A circle of arteries that supply blood to the brain. The Circle of Willis comprises the following arteries: Anterior cerebral artery (left and right); Anterior communicating artery; Internal carotid artery (left and right); Posterior cerebral artery (left and right); Posterior communicating artery (left and right).The basilar artery and middle cerebral arteries, supplying the brain, are also considered part of the circle.
http://purl.obolibrary.org/obo/UBERON_0003711	brachiocephalic vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava.
http://purl.obolibrary.org/obo/UBERON_0003713	splenic vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein.
http://purl.obolibrary.org/obo/UBERON_0003714	neural tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.
http://purl.obolibrary.org/obo/UBERON_0003715	splanchnic nerve	http://purl.obolibrary.org/obo/UBERON_0034729	sympathetic nerve		The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.
http://purl.obolibrary.org/obo/UBERON_0003716	recurrent laryngeal nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A branch of the vagus nerve that supplies motor function and sensation to the larynx (voice box). It travels within the endoneurium. It is the nerve of the 6th Branchial Arch.
http://purl.obolibrary.org/obo/UBERON_0003721	lingual nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The lingual nerve is a branch of the mandibular nerve (CN V3), itself a branch of the trigeminal nerve, which supplies sensory innervation to the tongue. It also carries fibers from the facial nerve, which return taste information from the anterior two thirds of the tongue.
http://purl.obolibrary.org/obo/UBERON_0003723	vestibular nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The vestibular nerve is one of the two branches of the Vestibulocochlear nerve (the cochlear nerve being the other). It goes to the semicircular canals via the vestibular ganglion. It receives positional information. Axons of the vestibular nerve synapse in the vestibular nucleus on the lateral floor and wall of the fourth ventricle in the pons and medulla. It arises from bipolar cells in the vestibular ganglion, ganglion of Scarpa, which is situated in the upper part of the outer end of the internal auditory meatus. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0003724	musculocutaneous nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A large branch of the brachial plexus supplying various parts of the upper arm (as flexor muscles) and forearm (as the skin).
http://purl.obolibrary.org/obo/UBERON_0003725	cervical nerve plexus	http://purl.obolibrary.org/obo/UBERON_0001813	spinal nerve plexus		An arrangement of nerve fibers, running from the spine that travels to the head and neck where it innervates skin and muscle.
http://purl.obolibrary.org/obo/UBERON_0003726	thoracic nerve	http://purl.obolibrary.org/obo/UBERON_0001780	spinal nerve		The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls.
http://purl.obolibrary.org/obo/UBERON_0003727	intercostal nerve	http://purl.obolibrary.org/obo/UBERON_0001780	spinal nerve		The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucous membrane that lines the mouth.
http://purl.obolibrary.org/obo/UBERON_0003820	prostate bud	http://purl.obolibrary.org/obo/UBERON_0005153	epithelial bud		A region of the fetal urogenital sinus epithelium destined to become the prostate[GO].
http://purl.obolibrary.org/obo/UBERON_0003821	metapodium bone	http://purl.obolibrary.org/obo/UBERON_0012357	digitopodium bone		A bone of the metapodial skeleton.
http://purl.obolibrary.org/obo/UBERON_0003822	forelimb stylopod	http://purl.obolibrary.org/obo/UBERON_0008785	upper limb segment		The part of the forelimb between pectoral region and the elbow, corresponding to the humerus.
http://purl.obolibrary.org/obo/UBERON_0003823	hindlimb zeugopod	http://purl.obolibrary.org/obo/UBERON_0008784	lower limb segment		The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants.
http://purl.obolibrary.org/obo/UBERON_0003824	nerve of thoracic segment	http://purl.obolibrary.org/obo/UBERON_0003439	nerve of trunk region		A nerve that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003825	nerve of abdominal segment	http://purl.obolibrary.org/obo/UBERON_0003439	nerve of trunk region		A nerve that is part of an abdominal segment of trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003826	upper leg bone	http://purl.obolibrary.org/obo/UBERON_0005893	leg bone		A bone that is part of a hindlimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003827	thoracic segment bone	http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ		A bone that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003828	abdominal segment bone	http://purl.obolibrary.org/obo/UBERON_0005173	abdominal segment element		A bone that is part of an abdominal segment of trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003829	urethra muscle tissue	http://purl.obolibrary.org/obo/UBERON_0005090	muscle structure		Any muscle tissue that is part of the urethra.
http://purl.obolibrary.org/obo/UBERON_0003830	thoracic segment muscle	http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ		Any muscle organ that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003831	respiratory system muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		Any muscle organ that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003832	esophagus muscle	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		Any muscle organ that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003833	abdominal segment muscle	http://purl.obolibrary.org/obo/UBERON_0005173	abdominal segment element		A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003834	thoracic segment blood vessel	http://purl.obolibrary.org/obo/UBERON_0003513	trunk blood vessel		A blood vessel that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003835	abdominal segment blood vessel	http://purl.obolibrary.org/obo/UBERON_0003513	trunk blood vessel		A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003836	abdominal segment skin	http://purl.obolibrary.org/obo/UBERON_0001085	skin of trunk		A skin of body that is part of an abdominal segment of trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003837	thoracic segment connective tissue	http://purl.obolibrary.org/obo/UBERON_0003586	trunk connective tissue		A portion of connective tissue that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003838	abdominal segment connective tissue	http://purl.obolibrary.org/obo/UBERON_0003586	trunk connective tissue		A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003839	forelimb joint	http://purl.obolibrary.org/obo/UBERON_0003657	limb joint		A limb joint that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003840	hindlimb joint	http://purl.obolibrary.org/obo/UBERON_0003657	limb joint		A limb joint that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003841	autopod joint	http://purl.obolibrary.org/obo/UBERON_0003657	limb joint		A limb joint that is part of an autopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003842	neural tube lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that surrounded_by a neural tube.
http://purl.obolibrary.org/obo/UBERON_0003843	dental epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelium that is part of a developing tooth or dental organ.
http://purl.obolibrary.org/obo/UBERON_0003844	upper eyelid epithelium	http://purl.obolibrary.org/obo/UBERON_0035034	eyelid epithelium		An epithelium that is part of an upper eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003845	lower eyelid epithelium	http://purl.obolibrary.org/obo/UBERON_0035034	eyelid epithelium		An epithelium that is part of a lower eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003846	thymus epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a thymus, forming a supporting framework[MP,modified].
http://purl.obolibrary.org/obo/UBERON_0003847	thyroid artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies a thyroid gland.
http://purl.obolibrary.org/obo/UBERON_0003848	gonadal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0003849	mesencephalic neural crest	http://purl.obolibrary.org/obo/UBERON_0003099	cranial neural crest		A neural crest that has_potential_to_developmentally_contribute_to a midbrain.
http://purl.obolibrary.org/obo/UBERON_0003850	telencephalon neural crest	http://purl.obolibrary.org/obo/UBERON_0002342	neural crest		A neural crest that has_potential_to_developmentally_contribute_to a telencephalon.
http://purl.obolibrary.org/obo/UBERON_0003851	diencephalon neural crest	http://purl.obolibrary.org/obo/UBERON_0002342	neural crest		A neural crest that has_potential_to_developmentally_contribute_to a diencephalon.
http://purl.obolibrary.org/obo/UBERON_0003852	rhombencephalon neural crest	http://purl.obolibrary.org/obo/UBERON_0003099	cranial neural crest		A neural crest that has_potential_to_developmentally_contribute_to a hindbrain.
http://purl.obolibrary.org/obo/UBERON_0003853	spinal cord neural crest	http://purl.obolibrary.org/obo/UBERON_0002342	neural crest		A neural crest that has_potential_to_developmentally_contribute_to a spinal cord.
http://purl.obolibrary.org/obo/UBERON_0003854	spinal cord neural plate	http://purl.obolibrary.org/obo/UBERON_0003075	neural plate		A neural plate that develops_from a future spinal cord.
http://purl.obolibrary.org/obo/UBERON_0003855	gonad mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Mesenchyme that is part of a developing gonad [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003856	uncondensed odontogenic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0007529	loose mesenchyme tissue		Mesenchyme enclosed by a dental organ that gives rise to an odontogenic papilla.
http://purl.obolibrary.org/obo/UBERON_0003857	upper eyelid mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010330	eyelid mesenchyme		Mesenchyme that is part of a developing upper eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003858	lower eyelid mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010330	eyelid mesenchyme		Mesenchyme that is part of a developing lower eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003859	forelimb mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009749	limb mesenchyme		Mesenchyme that is part of a developing forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003860	hindlimb mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009749	limb mesenchyme		Mesenchyme that is part of a developing hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003861	neural arch	http://purl.obolibrary.org/obo/UBERON_0010358	arch of centrum of vertebra		Posterior part of a vertebra that consists of a pair of pedicles and a pair of laminae, and supports seven processes: four articular processes, two transverse processes one spinous process[WP]. ZFA: A neural arch encloses the neural canal and typically meets its partner to form a neural spine.
http://purl.obolibrary.org/obo/UBERON_0003862	pedal digit 4 phalanx	http://purl.obolibrary.org/obo/UBERON_0015034	pedal digit 4 phalanx endochondral element		A phalanx that is part of a foot digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003863	pedal digit 5 phalanx	http://purl.obolibrary.org/obo/UBERON_0015035	pedal digit 5 phalanx endochondral element		A phalanx that is part of a foot digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003864	middle phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004301	middle phalanx		A middle phalanx that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003865	distal phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx		A distal phalanx that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003866	middle phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0004301	middle phalanx		A middle phalanx that is part of a toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003867	distal phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx		A distal phalanx that is part of a pedal digit [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003868	proximal phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx		A proximal phalanx that is part of a pedal digit [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003869	presumptive ganglion	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a ganglion.
http://purl.obolibrary.org/obo/UBERON_0003885	mesometrium	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		A mesentery that is part of a uterus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003886	future coelemic cavity lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that has the potential to develop into a coelemic cavity lumen.
http://purl.obolibrary.org/obo/UBERON_0003887	intraembryonic coelom	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
http://purl.obolibrary.org/obo/UBERON_0003890	Mullerian duct	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM].
http://purl.obolibrary.org/obo/UBERON_0003891	stroma	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma.
http://purl.obolibrary.org/obo/UBERON_0003893	capsule	http://purl.obolibrary.org/obo/UBERON_0000158	membranous layer		A cover or envelope partly or wholly surrounding a structure. Examples: egg shell, articular capsules, renal capsules[WP].
http://purl.obolibrary.org/obo/UBERON_0003894	liver primordium	http://purl.obolibrary.org/obo/UBERON_0009497	epithelium of foregut-midgut junction		A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum.
http://purl.obolibrary.org/obo/UBERON_0003895	hypaxial myotome region	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		Portion of myotome that is ventral to the horizontal septum.
http://purl.obolibrary.org/obo/UBERON_0003897	axial muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		One of the skeletal muscles of the head and neck, spine, and ribs.
http://purl.obolibrary.org/obo/UBERON_0003898	skeletal muscle tissue of trunk	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue in the trunk.
http://purl.obolibrary.org/obo/UBERON_0003900	epaxial myotome region	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		Portion of myotome that is dorsal to the horizontal septum.
http://purl.obolibrary.org/obo/UBERON_0003901	horizontal septum	http://purl.obolibrary.org/obo/UBERON_0003037	septum		A logitudinal sheet of continuous connective tissue partition developing at the apex of the chevron-shaped myotome and separating dorsal (epaxial) and ventral (hypaxial) body wall muscle masses; each is destined to become, respectively, the epaxial and hyopaxial musculature.
http://purl.obolibrary.org/obo/UBERON_0003902	retinal neural layer	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The part of the retina that contains neurons and photoreceptor cells[GO].
http://purl.obolibrary.org/obo/UBERON_0003907	left atrioventricular canal	http://purl.obolibrary.org/obo/UBERON_0002087	atrioventricular canal		An atrioventricular canal that is in the left side of a atrioventricular region.
http://purl.obolibrary.org/obo/UBERON_0003908	right atrioventricular canal	http://purl.obolibrary.org/obo/UBERON_0002087	atrioventricular canal		An atrioventricular canal that is in the right side of a atrioventricular region.
http://purl.obolibrary.org/obo/UBERON_0003909	sinusoid	http://purl.obolibrary.org/obo/UBERON_2005260	fenestrated capillary		Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP].
http://purl.obolibrary.org/obo/UBERON_0003910	splenic sinusoid	http://purl.obolibrary.org/obo/UBERON_0003909	sinusoid		Wide vessels in the spleen that drain into trabecular veins[WP].
http://purl.obolibrary.org/obo/UBERON_0003911	choroid plexus epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		The epithelial component of the choroid plexus. Consists of cuboidal epithelial cells surrounding a core of capillaries and loose connective tissue.
http://purl.obolibrary.org/obo/UBERON_0003913	tooth-like structure	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
http://purl.obolibrary.org/obo/UBERON_0003914	epithelial tube	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
http://purl.obolibrary.org/obo/UBERON_0003915	endothelial tube	http://purl.obolibrary.org/obo/UBERON_0003914	epithelial tube		Any endothelium that has the quality of being cylindrical [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003916	fat pad	http://purl.obolibrary.org/obo/UBERON_0001013	adipose tissue		A mass of closely packed fat cells (adipose tissue) surrounded by fibrous tissue septa[TMD].
http://purl.obolibrary.org/obo/UBERON_0003918	kidney mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO].
http://purl.obolibrary.org/obo/UBERON_0003920	venous blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that carries blood from the capillaries toward the heart.
http://purl.obolibrary.org/obo/UBERON_0003921	pancreas primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Embryonic structure that develops into pancreatic bud.
http://purl.obolibrary.org/obo/UBERON_0003922	pancreatic epithelial bud	http://purl.obolibrary.org/obo/UBERON_0007499	epithelial sac		The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID].
http://purl.obolibrary.org/obo/UBERON_0003923	dorsal pancreatic bud	http://purl.obolibrary.org/obo/UBERON_0003922	pancreatic epithelial bud		Pancreatic bud that gives rise to the accessory pancreatic duct.
http://purl.obolibrary.org/obo/UBERON_0003924	ventral pancreatic bud	http://purl.obolibrary.org/obo/UBERON_0003922	pancreatic epithelial bud		Pancreatic bud that gives rise to the major pancreatic duct.
http://purl.obolibrary.org/obo/UBERON_0003928	digestive system duct	http://purl.obolibrary.org/obo/UBERON_0000058	duct		A duct that is part of a digestive system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that lines the lumen of the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0003930	atrioventricular canal endocardium	http://purl.obolibrary.org/obo/UBERON_0002165	endocardium		Endocardium that is part of the atrioventricular canal[ZFA,vetted].
http://purl.obolibrary.org/obo/UBERON_0003931	diencephalic white matter	http://purl.obolibrary.org/obo/UBERON_0019261	white matter of forebrain		White matter that is part of a diencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0003932	cartilage element of chondrocranium	http://purl.obolibrary.org/obo/UBERON_0003933	cranial cartilage		A cartilage element of chondrocranium. Example: neurocranial trabecula.
http://purl.obolibrary.org/obo/UBERON_0003933	cranial cartilage	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		A cartilage element that is part of the cranial skeleton.
http://purl.obolibrary.org/obo/UBERON_0003937	reproductive gland	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.
http://purl.obolibrary.org/obo/UBERON_0003942	somatosensory system	http://purl.obolibrary.org/obo/UBERON_0001032	sensory system		The sensory system for the sense of touch and pain.
http://purl.obolibrary.org/obo/UBERON_0003947	brain ventricle/choroid plexus	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		The brain ventricles or their associated choroid plexuses.
http://purl.obolibrary.org/obo/UBERON_0003951	ocular fundus	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope.
http://purl.obolibrary.org/obo/UBERON_0003952	anterior stroma of cornea	http://purl.obolibrary.org/obo/UBERON_0003566	head connective tissue		The anterior segment of the lamellated connective tissue layer of the cornea.
http://purl.obolibrary.org/obo/UBERON_0003953	posterior stroma of cornea	http://purl.obolibrary.org/obo/UBERON_0003566	head connective tissue		The posterior segment of the lamellated connective tissue layer of the cornea.
http://purl.obolibrary.org/obo/UBERON_0003954	squamoparietal suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		The articulation of the squamous portion of the temporal bones with the parietal bones[MP]. The squamosal suture arches backward from the pterion and connects the temporal squama with the lower border of the parietal: this suture is continuous behind with the short, nearly horizontal parietomastoid suture, which unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP].
http://purl.obolibrary.org/obo/UBERON_0003955	molar crown	http://purl.obolibrary.org/obo/UBERON_0003675	tooth crown		The part of a molar that is covered by enamel.
http://purl.obolibrary.org/obo/UBERON_0003956	aqueous drainage system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		The structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins.
http://purl.obolibrary.org/obo/UBERON_0003960	styloid process of temporal bone	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		Slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments.
http://purl.obolibrary.org/obo/UBERON_0003967	cutaneous elastic tissue	http://purl.obolibrary.org/obo/UBERON_0002521	elastic tissue		The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity.
http://purl.obolibrary.org/obo/UBERON_0003968	peripheral lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		The lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes.
http://purl.obolibrary.org/obo/UBERON_0003975	internal female genitalia	http://purl.obolibrary.org/obo/UBERON_0004175	internal genitalia		The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina.
http://purl.obolibrary.org/obo/UBERON_0003980	cerebellum fissure	http://purl.obolibrary.org/obo/UBERON_0014466	subarachnoid fissure		One of a set of deep furrows which divide the lobules of the cerebellum. Examples: postcentral, primary and secondary furrows.
http://purl.obolibrary.org/obo/UBERON_0003984	uterine tube infundibulum	http://purl.obolibrary.org/obo/UBERON_0013515	subdivision of oviduct		The funnel-like expansion of the abdominal extremity of the uterine tube[MP].
http://purl.obolibrary.org/obo/UBERON_0003988	thymus corticomedullary boundary	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells.
http://purl.obolibrary.org/obo/UBERON_0003999	hyoid bone body	http://purl.obolibrary.org/obo/UBERON_0010273	zone of hyoid bone		The main curve of the hyoid bone, from which the horns extend.
http://purl.obolibrary.org/obo/UBERON_0004000	tarsal gland acinus	http://purl.obolibrary.org/obo/UBERON_0011846	acinus of sebaceous gland		A sac-like structure comprising a sebaceous gland.
http://purl.obolibrary.org/obo/UBERON_0004001	olfactory bulb layer	http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer		Missing definition for term UBERON:0004001. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0004008	cerebellar plate	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium.
http://purl.obolibrary.org/obo/UBERON_0004015	embryonic-extraembryonic boundary	http://purl.obolibrary.org/obo/UBERON_0000015	non-material anatomical boundary		The connection between the embryo proper and extraembryonic tissues.
http://purl.obolibrary.org/obo/UBERON_0004016	dermatome	http://purl.obolibrary.org/obo/UBERON_0017650	developing mesenchymal structure		A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.
http://purl.obolibrary.org/obo/UBERON_0004022	germinal neuroepithelium	http://purl.obolibrary.org/obo/UBERON_0034706	proliferating neuroepithelium		The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells.
http://purl.obolibrary.org/obo/UBERON_0004035	cortical subplate	http://purl.obolibrary.org/obo/UBERON_0014950	layer of developing cerebral cortex		The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate.
http://purl.obolibrary.org/obo/UBERON_0004040	cortical intermediate zone	http://purl.obolibrary.org/obo/UBERON_0014950	layer of developing cerebral cortex		The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone.
http://purl.obolibrary.org/obo/UBERON_0004041	spleen primary B follicle	http://purl.obolibrary.org/obo/UBERON_0010422	primary nodular lymphoid tissue		The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp.
http://purl.obolibrary.org/obo/UBERON_0004042	spleen secondary B follicle	http://purl.obolibrary.org/obo/UBERON_0001745	secondary nodular lymphoid tissue		The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp.
http://purl.obolibrary.org/obo/UBERON_0004053	external male genitalia	http://purl.obolibrary.org/obo/UBERON_0004176	external genitalia		The external masculine genital organs.
http://purl.obolibrary.org/obo/UBERON_0004054	internal male genitalia	http://purl.obolibrary.org/obo/UBERON_0004175	internal genitalia		The internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands.
http://purl.obolibrary.org/obo/UBERON_0004058	biliary ductule	http://purl.obolibrary.org/obo/UBERON_0000025	tube		One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP].
http://purl.obolibrary.org/obo/UBERON_0004060	neural tube ventricular layer	http://purl.obolibrary.org/obo/UBERON_0034706	proliferating neuroepithelium		The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.
http://purl.obolibrary.org/obo/UBERON_0004061	neural tube mantle layer	http://purl.obolibrary.org/obo/UBERON_0034707	differentiating neuroepithelium		The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer.
http://purl.obolibrary.org/obo/UBERON_0004062	neural tube marginal layer	http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure		The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter.
http://purl.obolibrary.org/obo/UBERON_0004064	neural tube basal plate	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons.
http://purl.obolibrary.org/obo/UBERON_0004066	frontonasal prominence	http://purl.obolibrary.org/obo/UBERON_0009292	embryonic nasal process		The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout.
http://purl.obolibrary.org/obo/UBERON_0004067	lateral nasal prominence	http://purl.obolibrary.org/obo/UBERON_0009292	embryonic nasal process		The lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it.
http://purl.obolibrary.org/obo/UBERON_0004068	medial nasal prominence	http://purl.obolibrary.org/obo/UBERON_0009292	embryonic nasal process		The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it.
http://purl.obolibrary.org/obo/UBERON_0004084	genital labium	http://purl.obolibrary.org/obo/UBERON_8480029	skin of external genitalia		One of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening.
http://purl.obolibrary.org/obo/UBERON_0004087	vena cava	http://purl.obolibrary.org/obo/UBERON_0013768	great vessel of heart		Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart.
http://purl.obolibrary.org/obo/UBERON_0004088	orbital region	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present.
http://purl.obolibrary.org/obo/UBERON_0004089	midface	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		The middle of the face including the nose and its associated bony structures[MW].
http://purl.obolibrary.org/obo/UBERON_0004090	periorbital region	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Missing definition for term UBERON:0004090. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0004092	hypothalamus-pituitary axis	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Missing definition for term UBERON:0004092. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0004096	odontoid process of cervical vertebra 2	http://purl.obolibrary.org/obo/UBERON_0004530	bony projection		The toothlike process on the upper surface of the axis, which articulates with the atlas above[GAID].
http://purl.obolibrary.org/obo/UBERON_0004098	tibial plateaux	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		Missing definition for term UBERON:0004098. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0004099	joint space of elbow	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		Joint cavity shared by all the joints of the elbow. The elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis. All three share a joint cavity which is highly sinuated/scalloped/coved. Joint spaces of the elbow summarizes the joint cavity shared by all three adjoining joints of the elbow joint.
http://purl.obolibrary.org/obo/UBERON_0004100	renal collecting system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. It participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and antidiuretic hormone.
http://purl.obolibrary.org/obo/UBERON_0004101	nasolabial region	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		Missing definition for term UBERON:0004101. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0004103	alveolar ridge	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		One of the two jaw ridges either on the roof of the mouth between the upper teeth and the hard palate or on the bottom of the mouth behind the lower teeth[WP]. The alveolar ridges contain the sockets (alveoli) of the teeth[HP].
http://purl.obolibrary.org/obo/UBERON_0004104	hairline	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		Anatomical line demarcating the boundary between forehead and scalp.
http://purl.obolibrary.org/obo/UBERON_0004105	subungual region	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		Region beneath a nail or claw.
http://purl.obolibrary.org/obo/UBERON_0004106	crus of ear	http://purl.obolibrary.org/obo/UBERON_0001867	cartilage of external ear		Horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear.
http://purl.obolibrary.org/obo/UBERON_0004109	cortex of humerus	http://purl.obolibrary.org/obo/UBERON_0005808	bone tissue of long bone		The outer or sperficial part of the humerus.
http://purl.obolibrary.org/obo/UBERON_0004110	midnasal cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		An anatomical cavity that is the combination of the cavity between the nares and the choanae[HP,modified].
http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Any tube, opening or passage that connects two distinct anatomical spaces.
http://purl.obolibrary.org/obo/UBERON_0004113	muscle of auditory ossicle	http://purl.obolibrary.org/obo/UBERON_0002376	cranial muscle		A muscle of the tympanic cavity that attaches to an auditory ossicle.
http://purl.obolibrary.org/obo/UBERON_0004114	tympanic cavity	http://purl.obolibrary.org/obo/UBERON_0010064	open anatomical space		Small cavity surrounding the bones of the middle ear.
http://purl.obolibrary.org/obo/UBERON_0004115	blood vessel of tympanic cavity	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A blood vessel that is part of a tympanic cavity [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004116	nerve of tympanic cavity	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A nerve that is part of a tympanic cavity [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004118	vasculature of iris	http://purl.obolibrary.org/obo/UBERON_0002203	vasculature of eye		A vasculature that is part of a iris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that develops (entirely or partially) from the endoderm.
http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that develops (entirely or partially) from the mesoderm.
http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that develops (entirely or partially) from the ectoderm.
http://purl.obolibrary.org/obo/UBERON_0004122	genitourinary system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.
http://purl.obolibrary.org/obo/UBERON_0004123	myocardial layer	http://purl.obolibrary.org/obo/UBERON_0005983	heart layer		Any of the layers of the myocardium. Example: compact layer, trabecular layer.
http://purl.obolibrary.org/obo/UBERON_0004124	myocardium trabecular layer	http://purl.obolibrary.org/obo/UBERON_0004123	myocardial layer		The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA].
http://purl.obolibrary.org/obo/UBERON_0004126	trabecular layer of ventricle	http://purl.obolibrary.org/obo/UBERON_0004124	myocardium trabecular layer		A myocardium trabecular layer that is part of a cardiac ventricle.
http://purl.obolibrary.org/obo/UBERON_0004128	optic vesicle	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA].
http://purl.obolibrary.org/obo/UBERON_0004130	cerebellar layer	http://purl.obolibrary.org/obo/UBERON_0016548	central nervous system gray matter layer		A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo.
http://purl.obolibrary.org/obo/UBERON_0004133	salivatory nucleus	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		Missing definition for term UBERON:0004133. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0004139	cardiogenic plate	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The first recognizable structure derived from the heart field.
http://purl.obolibrary.org/obo/UBERON_0004140	primary heart field	http://purl.obolibrary.org/obo/UBERON_0007688	anlage		A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
http://purl.obolibrary.org/obo/UBERON_0004141	heart tube	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		An epithelial tube that will give rise to the mature heart.
http://purl.obolibrary.org/obo/UBERON_0004142	outflow tract septum	http://purl.obolibrary.org/obo/UBERON_0002099	cardiac septum		The outflow tract septum is a partition in the outflow tract.
http://purl.obolibrary.org/obo/UBERON_0004145	outflow tract	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		The outflow tract is the portion of the heart through which blood flows into the arteries.
http://purl.obolibrary.org/obo/UBERON_0004148	cardiac vein	http://purl.obolibrary.org/obo/UBERON_0013140	systemic vein		Vein of heart that drains the myocardium.
http://purl.obolibrary.org/obo/UBERON_0004151	cardiac chamber	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A cardiac chamber surrounds an enclosed cavity within the heart.
http://purl.obolibrary.org/obo/UBERON_0004160	proepicardium	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium.
http://purl.obolibrary.org/obo/UBERON_0004161	septum transversum	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG].
http://purl.obolibrary.org/obo/UBERON_0004175	internal genitalia	http://purl.obolibrary.org/obo/UBERON_0003133	reproductive organ		The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.
http://purl.obolibrary.org/obo/UBERON_0004176	external genitalia	http://purl.obolibrary.org/obo/UBERON_0003133	reproductive organ		The external genitalia are the outer sex organs, such as the penis or vulva in mammals.
http://purl.obolibrary.org/obo/UBERON_0004177	hemopoietic organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Organ that is part of the hematopoietic system.
http://purl.obolibrary.org/obo/UBERON_0004178	aorta smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004695	arterial system smooth muscle		The nonstriated, involuntary muscle tissue located in the wall of the aorta.
http://purl.obolibrary.org/obo/UBERON_0004180	mammary gland fat	http://purl.obolibrary.org/obo/UBERON_0003584	mammary gland connective tissue		The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts.
http://purl.obolibrary.org/obo/UBERON_0004182	mammary gland cord	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		The solid cord of epithelial cells that emerges from the mammary bud and grows down from the primary mammary mesenchyme and into a second stromal compartment, the fat pad precursor, beneath the dermis.
http://purl.obolibrary.org/obo/UBERON_0004184	prostate gland stroma	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland.
http://purl.obolibrary.org/obo/UBERON_0004185	endodermal part of digestive tract	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		A portions of the gut that is derived from endoderm.
http://purl.obolibrary.org/obo/UBERON_0004186	olfactory bulb mitral cell layer	http://purl.obolibrary.org/obo/UBERON_0004001	olfactory bulb layer		The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer.
http://purl.obolibrary.org/obo/UBERON_0004188	glomerular epithelium	http://purl.obolibrary.org/obo/UBERON_0004211	nephron epithelium		The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.
http://purl.obolibrary.org/obo/UBERON_0004189	glomerular endothelium	http://purl.obolibrary.org/obo/UBERON_0004852	cardiovascular system endothelium		The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus.
http://purl.obolibrary.org/obo/UBERON_0004190	renal glomerulus vasculature	http://purl.obolibrary.org/obo/UBERON_0006544	kidney vasculature		The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus.
http://purl.obolibrary.org/obo/UBERON_0004198	comma-shaped body	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron.
http://purl.obolibrary.org/obo/UBERON_0004199	S-shaped body	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron.
http://purl.obolibrary.org/obo/UBERON_0004200	kidney pyramid	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts.
http://purl.obolibrary.org/obo/UBERON_0004203	cortical collecting duct	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex.
http://purl.obolibrary.org/obo/UBERON_0004205	inner medullary collecting duct	http://purl.obolibrary.org/obo/UBERON_0001232	collecting duct of renal tubule		The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla.
http://purl.obolibrary.org/obo/UBERON_0004208	nephrogenic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron.
http://purl.obolibrary.org/obo/UBERON_0004209	renal vesicle	http://purl.obolibrary.org/obo/UBERON_0007503	epithelial vesicle		The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.
http://purl.obolibrary.org/obo/UBERON_0004211	nephron epithelium	http://purl.obolibrary.org/obo/UBERON_0004819	kidney epithelium		The nephron epithelium is a tissue that covers the surface of a nephron.
http://purl.obolibrary.org/obo/UBERON_0004212	glomerular capillary	http://purl.obolibrary.org/obo/UBERON_0003527	kidney capillary		The small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus.
http://purl.obolibrary.org/obo/UBERON_0004214	upper leg nerve	http://purl.obolibrary.org/obo/UBERON_0003431	leg nerve		A nerve that is part of a hindlimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004215	back nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is part of a back [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004216	lower arm nerve	http://purl.obolibrary.org/obo/UBERON_0003433	arm nerve		A nerve that is part of a lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004217	upper arm nerve	http://purl.obolibrary.org/obo/UBERON_0003433	arm nerve		A nerve that is part of a forelimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004218	lower leg nerve	http://purl.obolibrary.org/obo/UBERON_0003431	leg nerve		A nerve that is part of a lower leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004219	urethra smooth muscle layer	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a urethra [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004220	large intestine smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004221	intestine smooth muscle		A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004221	intestine smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004226	gastrointestinal system smooth muscle		A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004222	stomach smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004226	gastrointestinal system smooth muscle		A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004223	vagina smooth muscle	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A portion of smooth muscle tissue that is part of a vagina [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004224	muscular coat of vas deferens	http://purl.obolibrary.org/obo/UBERON_0034933	layer of smooth muscle tissue		A muscular coat that is part of a vas deferens [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004225	respiratory system smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004226	gastrointestinal system smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004227	kidney pelvis smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		The smooth muscle tissue surrounding the urothelium of the kidney pelvis.
http://purl.obolibrary.org/obo/UBERON_0004228	urinary bladder smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a urinary bladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004230	urinary bladder neck smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004228	urinary bladder smooth muscle		A portion of smooth muscle tissue that is part of a neck of urinary bladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004231	anal region smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004232	lymphatic vessel smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004233	lower respiratory tract smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004225	respiratory system smooth muscle		A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004234	iris smooth muscle	http://purl.obolibrary.org/obo/UBERON_0003386	smooth muscle of eye		A portion of smooth muscle tissue that is part of a iris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004235	mammary gland smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a mammary gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004236	arteriole smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004695	arterial system smooth muscle		A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004237	blood vessel smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		Smooth muscle found within, and composing the majority of the wall of blood vessels.
http://purl.obolibrary.org/obo/UBERON_0004238	spleen smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004239	small intestine smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004221	intestine smooth muscle		A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004240	gallbladder smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004242	bronchus smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004233	lower respiratory tract smooth muscle		A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004243	prostate gland smooth muscle	http://purl.obolibrary.org/obo/UBERON_0008715	muscle tissue of prostate		A portion of smooth muscle tissue that is part of a prostate gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004245	oviduct smooth muscle	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004246	outflow tract smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004247	bone of dorsum	http://purl.obolibrary.org/obo/UBERON_0005174	dorsal region element		A bone that is part of the dorsal region of an animal.
http://purl.obolibrary.org/obo/UBERON_0004248	pedal digit bone	http://purl.obolibrary.org/obo/UBERON_0012359	pedal digitopodium bone		A bone that is part of a hindlimb digit. Typically phalanges but may include sesamoids.
http://purl.obolibrary.org/obo/UBERON_0004249	manual digit bone	http://purl.obolibrary.org/obo/UBERON_0012358	manual digitopodium bone		A bone that is part of a forelimb digit. Typically phalanges but may include sesamoids.
http://purl.obolibrary.org/obo/UBERON_0004250	upper arm bone	http://purl.obolibrary.org/obo/UBERON_0003460	arm bone		A bone that is part of a forelimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004251	hindlimb zeugopod bone	http://purl.obolibrary.org/obo/UBERON_0005893	leg bone		A bone that is part of a lower leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004252	hindlimb stylopod muscle	http://purl.obolibrary.org/obo/UBERON_0001383	muscle of leg		Any muscle organ that is part of a hindlimb stylopod (upper leg)[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004253	skin muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		Any muscle organ that is part of a skin of body [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004254	forelimb zeugopod muscle	http://purl.obolibrary.org/obo/UBERON_0001499	muscle of arm		Any muscle organ that is part of a forelimb zeugopod (lower arm)[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004255	forelimb stylopod muscle	http://purl.obolibrary.org/obo/UBERON_0001499	muscle of arm		Any muscle organ that is part of a forelimb stylopod (upper arm)[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004256	hindlimb zeugopod muscle	http://purl.obolibrary.org/obo/UBERON_0001383	muscle of leg		Any muscle organ that is part of a hindlimb zeugopod (lower leg) [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004257	upper leg blood vessel	http://purl.obolibrary.org/obo/UBERON_0003503	leg blood vessel		A blood vessel that is part of a hindlimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004258	back blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a back [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004259	lower arm blood vessel	http://purl.obolibrary.org/obo/UBERON_0003507	arm blood vessel		A blood vessel that is part of a lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004260	upper arm blood vessel	http://purl.obolibrary.org/obo/UBERON_0003507	arm blood vessel		A blood vessel that is part of a forelimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004261	lower leg blood vessel	http://purl.obolibrary.org/obo/UBERON_0003503	leg blood vessel		A blood vessel that is part of a lower leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004262	upper leg skin	http://purl.obolibrary.org/obo/UBERON_0001511	skin of leg		A zone of skin that is part of a hindlimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004263	upper arm skin	http://purl.obolibrary.org/obo/UBERON_0002427	arm skin		A zone of skin that is part of a forelimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004264	lower leg skin	http://purl.obolibrary.org/obo/UBERON_0001511	skin of leg		A zone of skin that is part of a lower leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004265	outflow tract myocardium	http://purl.obolibrary.org/obo/UBERON_0002349	myocardium		A myocardium that is part of a outflow tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004266	upper leg connective tissue	http://purl.obolibrary.org/obo/UBERON_0003569	leg connective tissue		A portion of connective tissue that is part of a hindlimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004267	back connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A portion of connective tissue that is part of a back [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004268	lower arm connective tissue	http://purl.obolibrary.org/obo/UBERON_0003573	arm connective tissue		A portion of connective tissue that is part of a lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004269	upper arm connective tissue	http://purl.obolibrary.org/obo/UBERON_0003573	arm connective tissue		A portion of connective tissue that is part of a forelimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004270	lower leg connective tissue	http://purl.obolibrary.org/obo/UBERON_0003569	leg connective tissue		A portion of connective tissue that is part of a lower leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004271	outflow tract pericardium	http://purl.obolibrary.org/obo/UBERON_0002407	pericardium		A pericardium that is part of a outflow tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004273	cartilaginous joint suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		A cranial suture that is part of a cartilaginous joint [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004274	lateral ventricle choroid plexus epithelium	http://purl.obolibrary.org/obo/UBERON_0003911	choroid plexus epithelium		A choroid plexus epithelium that is part of a lateral ventricle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004275	third ventricle choroid plexus epithelium	http://purl.obolibrary.org/obo/UBERON_0003911	choroid plexus epithelium		A choroid plexus epithelium that is part of a third ventricle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004276	fourth ventricle choroid plexus epithelium	http://purl.obolibrary.org/obo/UBERON_0003911	choroid plexus epithelium		A choroid plexus epithelium that is part of a fourth ventricle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004277	eye muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		A muscle that is part of the eye region.
http://purl.obolibrary.org/obo/UBERON_0004288	skeleton	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.
http://purl.obolibrary.org/obo/UBERON_0004290	dermomyotome	http://purl.obolibrary.org/obo/UBERON_0016888	transitional anatomical structure		The bilaminar epithelium formed from the myotome and dermatome.
http://purl.obolibrary.org/obo/UBERON_0004291	heart rudiment	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.
http://purl.obolibrary.org/obo/UBERON_0004292	cardiac skeleton	http://purl.obolibrary.org/obo/UBERON_0003837	thoracic segment connective tissue		Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart.
http://purl.obolibrary.org/obo/UBERON_0004293	parasympathetic nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is part of a parasympathetic nervous system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004294	glomerular capillary endothelium	http://purl.obolibrary.org/obo/UBERON_0004189	glomerular endothelium		An endothelium that is part of a glomerular capillary.
http://purl.obolibrary.org/obo/UBERON_0004295	sympathetic nerve trunk	http://purl.obolibrary.org/obo/UBERON_0002464	nerve trunk		A nerve trunk that is part of a sympathetic nervous system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004296	respiratory system lymphatic vessel smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004232	lymphatic vessel smooth muscle		A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004297	respiratory system blood vessel smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004237	blood vessel smooth muscle		A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx	http://purl.obolibrary.org/obo/UBERON_0003221	phalanx		Distal-most phalanx within a digit.
http://purl.obolibrary.org/obo/UBERON_0004301	middle phalanx	http://purl.obolibrary.org/obo/UBERON_0003221	phalanx		A phalanx located between proximal and distal phalanges.
http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx	http://purl.obolibrary.org/obo/UBERON_0003221	phalanx		Proximal-most phalanx within a digit.
http://purl.obolibrary.org/obo/UBERON_0004311	distal phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0014484	distal phalanx of digit 2		A distal phalanx that is part of a hand digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004312	distal phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0014485	distal phalanx of digit 3		A distal phalanx that is part of a hand digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004313	distal phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0014486	distal phalanx of digit 4		A distal phalanx that is part of a hand digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004314	distal phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0014487	distal phalanx of digit 5		A distal phalanx that is part of a hand digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004315	distal phalanx of pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0014483	distal phalanx of digit 1		A distal phalanx that is part of a foot digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004316	distal phalanx of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0014484	distal phalanx of digit 2		A distal phalanx that is part of a foot digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004317	distal phalanx of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0014485	distal phalanx of digit 3		A distal phalanx that is part of a foot digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004318	distal phalanx of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0014486	distal phalanx of digit 4		A distal phalanx that is part of a foot digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004319	distal phalanx of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0014487	distal phalanx of digit 5		A distal phalanx that is part of a foot digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004320	middle phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0014488	middle phalanx of digit 2		A middle phalanx that is part of a hand digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004321	middle phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0014489	middle phalanx of digit 3		A middle phalanx that is part of a hand digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004322	middle phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0014490	middle phalanx of digit 4		A middle phalanx that is part of a hand digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004323	middle phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0014491	middle phalanx of digit 5		A middle phalanx that is part of a hand digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004324	middle phalanx of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0014488	middle phalanx of digit 2		A middle phalanx that is part of a foot digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004325	middle phalanx of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0014489	middle phalanx of digit 3		A middle phalanx that is part of a foot digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004326	middle phalanx of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0014490	middle phalanx of digit 4		A middle phalanx that is part of a pedal digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004327	middle phalanx of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0014491	middle phalanx of digit 5		A middle phalanx that is part of a pedal digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004328	proximal phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0014502	proximal phalanx of digit 2		A proximal phalanx that is part of a hand digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004329	proximal phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0014503	proximal phalanx of digit 3		A proximal phalanx that is part of a hand digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004330	proximal phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0014504	proximal phalanx of digit 4		A proximal phalanx that is part of a hand digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004331	proximal phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0014505	proximal phalanx of digit 5		A proximal phalanx that is part of a hand digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004332	proximal phalanx of pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0014501	proximal phalanx of digit 1		A proximal phalanx that is part of a pedal digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004333	proximal phalanx of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0014502	proximal phalanx of digit 2		A proximal phalanx that is part of a pedal digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004334	proximal phalanx of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0014503	proximal phalanx of digit 3		A proximal phalanx that is part of a pedal digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004335	proximal phalanx of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0014504	proximal phalanx of digit 4		A proximal phalanx that is part of a pedal digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004336	proximal phalanx of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0014505	proximal phalanx of digit 5		A proximal phalanx that is part of a pedal digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004337	distal phalanx of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0014483	distal phalanx of digit 1		A distal phalanx that is part of a hand digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004338	proximal phalanx of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0014501	proximal phalanx of digit 1		A proximal phalanx that is part of a hand digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004339	vault of skull	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Upper part of skull, consisting of parietals, frontals, post-parietals, and in some species the squamosal and a portion of the alisphenoid.
http://purl.obolibrary.org/obo/UBERON_0004340	allantois	http://purl.obolibrary.org/obo/UBERON_0005631	extraembryonic membrane		A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals[VHOG].
http://purl.obolibrary.org/obo/UBERON_0004341	primitive streak	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The primitive streak is a structure that forms during the early stages of avian, reptilian and mammalian embryonic development[WP]. the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm[MP].
http://purl.obolibrary.org/obo/UBERON_0004344	cardinal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		Any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0004345	trophectoderm	http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue		Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition.
http://purl.obolibrary.org/obo/UBERON_0004346	gubernaculum (male or female)	http://purl.obolibrary.org/obo/UBERON_0008845	nonskeletal ligament		Embryonic structures which begin as undifferentiated mesenchyme attaching to the caudal end of the gonads. The gubernaculum is present only during the development of the urinary and reproductive organs, being replaced by distinct vestiges in males and females[WP]. Enitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus[MP].
http://purl.obolibrary.org/obo/UBERON_0004347	limb bud	http://purl.obolibrary.org/obo/UBERON_0004357	paired limb/fin bud		An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP].
http://purl.obolibrary.org/obo/UBERON_0004348	optic eminence	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The embryonic structure that gives rise to the corneal ectoderm.
http://purl.obolibrary.org/obo/UBERON_0004353	female inguinal canal	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An inguinal canal that is part of a female organism. Conveys the round ligament + the ilioinguinal nerve.[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0004354	male inguinal canal	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An inguinal canal that is part of a male organism. Conveys the spermatic cord and its coverings + the ilioinguinal nerve.[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0004356	apical ectodermal ridge	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].
http://purl.obolibrary.org/obo/UBERON_0004357	paired limb/fin bud	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP].
http://purl.obolibrary.org/obo/UBERON_0004362	pharyngeal arch 1	http://purl.obolibrary.org/obo/UBERON_0002539	pharyngeal arch		The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries.
http://purl.obolibrary.org/obo/UBERON_0004364	ectoplacental cone	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta.
http://purl.obolibrary.org/obo/UBERON_0004365	vitelline blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		Blood vessel that is connected to the yolk sac.
http://purl.obolibrary.org/obo/UBERON_0004367	Descemet's membrane	http://purl.obolibrary.org/obo/UBERON_0005769	basement membrane of epithelium		A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].
http://purl.obolibrary.org/obo/UBERON_0004368	Reichert's cartilage	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A continuous cartilaginous formation in mesenchyme of the second pharyngeal arch in the embryo. The longer cranial or styloid segment is continuous with the otic capsule; its inferior end is angulated and is situated very close to the oropharynx. The smaller caudal segment is in contact with the body and greater horn of the hyoid cartilaginous structure.
http://purl.obolibrary.org/obo/UBERON_0004370	anterior limiting lamina of cornea	http://purl.obolibrary.org/obo/UBERON_0005769	basement membrane of epithelium		A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.
http://purl.obolibrary.org/obo/UBERON_0004374	vitelline vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		Vascular network that is connected to the yolk sac.
http://purl.obolibrary.org/obo/UBERON_0004375	bone of free limb or fin	http://purl.obolibrary.org/obo/UBERON_0010740	bone of appendage girdle complex		A bone that is part of an appendage [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004377	distal metaphysis	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is in the distal side of a diaphysis.
http://purl.obolibrary.org/obo/UBERON_0004378	proximal metaphysis	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is in the proximal side of a diaphysis.
http://purl.obolibrary.org/obo/UBERON_0004379	distal epiphysis	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is on the distal side of the bone.
http://purl.obolibrary.org/obo/UBERON_0004380	proximal epiphysis	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is on the proximal side of the bone.
http://purl.obolibrary.org/obo/UBERON_0004381	skeleton of limb	http://purl.obolibrary.org/obo/UBERON_0011582	paired limb/fin skeleton		The collection of all skeletal elements in an individual limb.
http://purl.obolibrary.org/obo/UBERON_0004382	epiphysis of humerus	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a humerus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004383	epiphysis of tibia	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a tibia [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004384	epiphysis of femur	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a femur [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004385	epiphysis of radius	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a radius [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004386	epiphysis of ulna	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of an ulna [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004387	epiphysis of phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004446	epiphysis of phalanx		An epiphysis that is part of a phalanx of a manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004388	epiphysis of fibula	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a fibula [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004389	epiphysis of metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0011973	epiphysis of phalanx of pes		An epiphysis that is part of a metatarsal bone [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a metacarpal bone [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004391	epiphysis of first metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone		An epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004392	epiphysis of second metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone		An epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004393	epiphysis of third metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone		An epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004394	epiphysis of fourth metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone		An epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004395	epiphysis of first metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004389	epiphysis of metatarsal bone		An epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004396	epiphysis of second metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004389	epiphysis of metatarsal bone		An epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004397	epiphysis of third metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004389	epiphysis of metatarsal bone		An epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004398	epiphysis of fourth metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004389	epiphysis of metatarsal bone		An epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004399	epiphysis of fifth metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004389	epiphysis of metatarsal bone		An epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004400	bone tissue of epiphysis	http://purl.obolibrary.org/obo/UBERON_0005808	bone tissue of long bone		A portion of bone tissue that is part of a epiphysis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004401	bone tissue of distal epiphysis	http://purl.obolibrary.org/obo/UBERON_0004400	bone tissue of epiphysis		A portion of bone tissue that is part of a distal epiphysis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004402	bone tissue of proximal epiphysis	http://purl.obolibrary.org/obo/UBERON_0004400	bone tissue of epiphysis		A portion of bone tissue that is part of a proximal epiphysis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004403	periosteum of epiphysis	http://purl.obolibrary.org/obo/UBERON_0016896	periosteum of long bone		A periosteum that is part of a epiphysis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004404	distal epiphysis of humerus	http://purl.obolibrary.org/obo/UBERON_0004382	epiphysis of humerus		A distal epiphysis that is part of a humerus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004405	distal epiphysis of tibia	http://purl.obolibrary.org/obo/UBERON_0004383	epiphysis of tibia		A distal epiphysis that is part of a tibia [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004406	distal epiphysis of femur	http://purl.obolibrary.org/obo/UBERON_0004384	epiphysis of femur		A distal epiphysis that is part of a femur [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004407	distal epiphysis of radius	http://purl.obolibrary.org/obo/UBERON_0004385	epiphysis of radius		A distal epiphysis that is part of a radius [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004408	distal epiphysis of ulna	http://purl.obolibrary.org/obo/UBERON_0004386	epiphysis of ulna		A distal epiphysis that is part of a ulna [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004409	distal epiphysis of phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004448	distal epiphysis of phalanx		A distal epiphysis that is part of a phalanx of manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004410	distal epiphysis of fibula	http://purl.obolibrary.org/obo/UBERON_0004388	epiphysis of fibula		A distal epiphysis that is part of a fibula [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004411	proximal epiphysis of humerus	http://purl.obolibrary.org/obo/UBERON_0004382	epiphysis of humerus		The upper extremity of the humerus (proximal humerus) consists of a large rounded head joined to the body by a constricted portion called the neck, and two eminences, the greater and lesser tubercles.
http://purl.obolibrary.org/obo/UBERON_0004412	proximal epiphysis of femur	http://purl.obolibrary.org/obo/UBERON_0004384	epiphysis of femur		A proximal epiphysis that is part of a femur [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004413	proximal epiphysis of radius	http://purl.obolibrary.org/obo/UBERON_0004385	epiphysis of radius		A proximal epiphysis that is part of a radius [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004414	proximal epiphysis of phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004447	proximal epiphysis of phalanx		A proximal epiphysis that is part of a phalanx of manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004415	proximal epiphysis of metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004389	epiphysis of metatarsal bone		A proximal epiphysis that is part of a metatarsal bone [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004416	proximal epiphysis of metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone		A proximal epiphysis that is part of a metacarpal bone [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004417	proximal epiphysis of phalanx of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0004414	proximal epiphysis of phalanx of manus		A proximal epiphysis that is part of a manual digit 1 phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004418	proximal epiphysis of phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0004414	proximal epiphysis of phalanx of manus		A proximal epiphysis that is part of a manual digit 2 phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004419	proximal epiphysis of phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0004414	proximal epiphysis of phalanx of manus		A proximal epiphysis that is part of a manual digit 3 phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004420	proximal epiphysis of phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0004414	proximal epiphysis of phalanx of manus		A proximal epiphysis that is part of a manual digit 4 phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004421	proximal epiphysis of phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0004414	proximal epiphysis of phalanx of manus		A proximal epiphysis that is part of a manual digit 5 phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004422	proximal epiphysis of first metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004416	proximal epiphysis of metacarpal bone		A proximal epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004423	proximal epiphysis of second metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004416	proximal epiphysis of metacarpal bone		A proximal epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004424	proximal epiphysis of third metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004416	proximal epiphysis of metacarpal bone		A proximal epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004425	proximal epiphysis of fourth metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004416	proximal epiphysis of metacarpal bone		A proximal epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004426	proximal epiphysis of fifth metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0011104	epiphysis of fifth metacarpal bone		A proximal epiphysis that is part of a metacarpal bone of digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004427	proximal epiphysis of first metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004415	proximal epiphysis of metatarsal bone		A proximal epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004428	proximal epiphysis of second metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004415	proximal epiphysis of metatarsal bone		A proximal epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004429	proximal epiphysis of third metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004415	proximal epiphysis of metatarsal bone		A proximal epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004430	proximal epiphysis of fourth metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004415	proximal epiphysis of metatarsal bone		A proximal epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004431	proximal epiphysis of fifth metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004415	proximal epiphysis of metatarsal bone		A proximal epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004432	proximal epiphysis of distal phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0011979	epiphysis of distal phalanx of manus		A proximal epiphysis that is part of a distal phalanx of manual digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004433	proximal epiphysis of distal phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0011979	epiphysis of distal phalanx of manus		A proximal epiphysis that is part of a distal phalanx of manual digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004434	proximal epiphysis of distal phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0011979	epiphysis of distal phalanx of manus		A proximal epiphysis that is part of a distal phalanx of manual digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004435	proximal epiphysis of distal phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0011979	epiphysis of distal phalanx of manus		A proximal epiphysis that is part of a distal phalanx of manual digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004436	proximal epiphysis of middle phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0011978	epiphysis of middle phalanx of manus		A proximal epiphysis that is part of a middle phalanx of manual digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004437	proximal epiphysis of middle phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0011978	epiphysis of middle phalanx of manus		A proximal epiphysis that is part of a middle phalanx of manual digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004438	proximal epiphysis of middle phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0011978	epiphysis of middle phalanx of manus		A proximal epiphysis that is part of a middle phalanx of manual digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004439	proximal epiphysis of middle phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0011978	epiphysis of middle phalanx of manus		A proximal epiphysis that is part of a middle phalanx of manual digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004440	proximal epiphysis of proximal phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0011977	epiphysis of proximal phalanx of manus		A proximal epiphysis that is part of a proximal phalanx of manual digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004441	proximal epiphysis of proximal phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0011977	epiphysis of proximal phalanx of manus		A proximal epiphysis that is part of a proximal phalanx of manual digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004442	proximal epiphysis of proximal phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0011977	epiphysis of proximal phalanx of manus		A proximal epiphysis that is part of a proximal phalanx of manual digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004443	proximal epiphysis of proximal phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0011977	epiphysis of proximal phalanx of manus		A proximal epiphysis that is part of a proximal phalanx of manual digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004444	proximal epiphysis of distal phalanx of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0011979	epiphysis of distal phalanx of manus		A proximal epiphysis that is part of a distal phalanx of manual digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004445	proximal epiphysis of proximal phalanx of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0011977	epiphysis of proximal phalanx of manus		A proximal epiphysis that is part of a proximal phalanx of manual digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004446	epiphysis of phalanx	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004447	proximal epiphysis of phalanx	http://purl.obolibrary.org/obo/UBERON_0004446	epiphysis of phalanx		A proximal epiphysis that is part of a phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004448	distal epiphysis of phalanx	http://purl.obolibrary.org/obo/UBERON_0004446	epiphysis of phalanx		A distal epiphysis that is part of a phalanx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004449	cerebral artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		One of three main pairs of arteries and their branches, which irrigate the cerebrum of the brain.
http://purl.obolibrary.org/obo/UBERON_0004451	trunk or cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0002412	vertebra		A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra.
http://purl.obolibrary.org/obo/UBERON_0004452	carpal region	http://purl.obolibrary.org/obo/UBERON_0008785	upper limb segment		A mesopodium that is part of a manus. Includes as parts the carpal skeleton and associated tissues[cjm]. The anatomical region surrounding the carpus including the distal parts of the bones of the forearm and the proximal parts of the metacarpus or five metacarpal bones and the series of joints between these bones, thus referred to as wrist joints. This region also includes the carpal tunnel, the anatomical snuff box, the flexor retinaculum, and the extensor retinaculum[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0004453	metacarpus region	http://purl.obolibrary.org/obo/UBERON_0009877	metapodium region		A metapodium region that is part of a manus.
http://purl.obolibrary.org/obo/UBERON_0004454	tarsal region	http://purl.obolibrary.org/obo/UBERON_0008784	lower limb segment		Mesopodial segment of the pes, including the tarsal skeleton and associated tissues.
http://purl.obolibrary.org/obo/UBERON_0004455	neurula embryo	http://purl.obolibrary.org/obo/UBERON_0000922	embryo		An embryo at the neurula stage.
http://purl.obolibrary.org/obo/UBERON_0004456	entire sense organ system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		Sum of all sensory systems in an organism.
http://purl.obolibrary.org/obo/UBERON_0004461	skeletal musculature of head	http://purl.obolibrary.org/obo/UBERON_0008229	craniocervical region musculature		Any collection of skeletal muscles that is part of a head [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004462	musculature of body wall	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Any collection of muscles that is part of a body wall [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004463	musculature of hindlimb stylopod	http://purl.obolibrary.org/obo/UBERON_0004466	musculature of leg		Any collection of muscles that is part of a hindlimb stylopod (upper leg / thigh)[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004464	musculature of thorax	http://purl.obolibrary.org/obo/UBERON_0004479	musculature of trunk		Any collection of muscles that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004465	musculature of neck	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Any collection of muscles that is part of a neck [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004466	musculature of leg	http://purl.obolibrary.org/obo/UBERON_0004482	musculature of lower limb		Any collection of muscles that is part of a lower leg or upper leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004467	musculature of pharynx	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		The collection of muscles that acts on the pharynx.
http://purl.obolibrary.org/obo/UBERON_0004469	musculature of back	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Any collection of muscles that is part of a back [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004470	musculature of pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0014792	musculature of pelvic complex		Any collection of muscles that is part of a pelvic girdle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004471	musculature of pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0014793	musculature of pectoral complex		A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles.
http://purl.obolibrary.org/obo/UBERON_0004473	musculature of face	http://purl.obolibrary.org/obo/UBERON_0008229	craniocervical region musculature		Any collection of muscles that is part of a face.
http://purl.obolibrary.org/obo/UBERON_0004474	musculature of arm	http://purl.obolibrary.org/obo/UBERON_0004481	musculature of upper limb		Any collection of muscles that is part of an arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004475	musculature of hip	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		The collection of muscles that form attachments to the hip skeleton.
http://purl.obolibrary.org/obo/UBERON_0004476	musculature of shoulder	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		The collection of muscles that form attachments to the shoulder skeleton.
http://purl.obolibrary.org/obo/UBERON_0004478	musculature of larynx	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		The collection of muscles that are part of the larynx.
http://purl.obolibrary.org/obo/UBERON_0004479	musculature of trunk	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Any collection of muscles that is part of a trunk [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004480	musculature of limb	http://purl.obolibrary.org/obo/UBERON_0007271	appendage musculature		Any collection of muscles that is part of a limb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004481	musculature of upper limb	http://purl.obolibrary.org/obo/UBERON_0007269	pectoral appendage musculature		Any collection of muscles that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004482	musculature of lower limb	http://purl.obolibrary.org/obo/UBERON_0007270	pelvic appendage musculature		Any collection of muscles that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004486	musculature of perineum	http://purl.obolibrary.org/obo/UBERON_0004479	musculature of trunk		Any collection of muscles that is part of a perineum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004487	musculature of forelimb zeugopod	http://purl.obolibrary.org/obo/UBERON_0004474	musculature of arm		Any collection of muscles that is part of a lower arm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004488	musculature of pes	http://purl.obolibrary.org/obo/UBERON_0004482	musculature of lower limb		Any collection of muscles that is part of a foot [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004489	musculature of manus	http://purl.obolibrary.org/obo/UBERON_0004481	musculature of upper limb		Any collection of muscles that is part of a manus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004490	cardiac muscle tissue of atrium	http://purl.obolibrary.org/obo/UBERON_0004493	cardiac muscle tissue of myocardium		A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004491	cardiac muscle tissue of interatrial septum	http://purl.obolibrary.org/obo/UBERON_0004492	cardiac muscle tissue of cardiac septum		A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004492	cardiac muscle tissue of cardiac septum	http://purl.obolibrary.org/obo/UBERON_0001133	cardiac muscle tissue		A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004493	cardiac muscle tissue of myocardium	http://purl.obolibrary.org/obo/UBERON_0001133	cardiac muscle tissue		A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004495	skeletal muscle tissue of diaphragm	http://purl.obolibrary.org/obo/UBERON_0004830	respiratory system skeletal muscle		A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004498	skeletal muscle tissue of quadriceps femoris	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a quadriceps femoris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004499	skeletal muscle tissue of tibialis anterior	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a tibialis anterior [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004500	skeletal muscle tissue of deltoid	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a deltoid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004502	skeletal muscle tissue of biceps brachii	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a biceps brachii [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004503	skeletal muscle tissue of digastric	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a digastric [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004504	skeletal muscle tissue of mylohyoid	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a mylohyoid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004505	skeletal muscle tissue of orbicularis oculi	http://purl.obolibrary.org/obo/UBERON_0003269	skeletal muscle tissue of eye		A portion of skeletal muscle tissue that is part of a orbicularis oculi [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004506	skeletal muscle tissue of masseter	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a masseter [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004507	skeletal muscle tissue of temporalis	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a temporalis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004508	skeletal muscle tissue of levator palpebrae superioris	http://purl.obolibrary.org/obo/UBERON_0003269	skeletal muscle tissue of eye		A portion of skeletal muscle tissue that is part of a levator palpebrae superioris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004509	skeletal muscle tissue of trapezius	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a trapezius [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004510	skeletal muscle tissue of pectoralis major	http://purl.obolibrary.org/obo/UBERON_0003898	skeletal muscle tissue of trunk		A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004511	skeletal muscle tissue of rectus abdominis	http://purl.obolibrary.org/obo/UBERON_0003898	skeletal muscle tissue of trunk		A portion of skeletal muscle tissue that is part of a rectus abdominis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004515	smooth muscle tissue of bronchiole	http://purl.obolibrary.org/obo/UBERON_0004233	lower respiratory tract smooth muscle		A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004516	smooth muscle tissue of terminal bronchiole	http://purl.obolibrary.org/obo/UBERON_0004515	smooth muscle tissue of bronchiole		A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004517	smooth muscle tissue of respiratory bronchiole	http://purl.obolibrary.org/obo/UBERON_0004515	smooth muscle tissue of bronchiole		A portion of smooth muscle tissue that is part of a respiratory bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004518	muscle of vertebral column	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		A muscle that is attached to a vertebra of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0004519	muscle of anal triangle	http://purl.obolibrary.org/obo/UBERON_0002379	perineal muscle		Any muscle organ that is part of a anal part of perineum.
http://purl.obolibrary.org/obo/UBERON_0004520	striated muscle tissue of prostate	http://purl.obolibrary.org/obo/UBERON_0008715	muscle tissue of prostate		A portion of striated muscle tissue that is part of a prostate gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004521	vasculature of muscle organ	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		A vasculature that is part of a muscle organ [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004522	vasculature of musculoskeletal system	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vasculature that is part of a musculoskeletal system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004527	alveolar process of maxilla	http://purl.obolibrary.org/obo/UBERON_0004103	alveolar ridge		The thickened ridge of bone that contains the tooth sockets on the maxilla.
http://purl.obolibrary.org/obo/UBERON_0004528	alveolar ridge of mandible	http://purl.obolibrary.org/obo/UBERON_0004103	alveolar ridge		The thickened ridge of bone that contains the tooth sockets on the mandible.
http://purl.obolibrary.org/obo/UBERON_0004529	anatomical projection	http://purl.obolibrary.org/obo/UBERON_0034768	morphological feature		A projection or outgrowth of tissue from a larger body or organ.
http://purl.obolibrary.org/obo/UBERON_0004530	bony projection	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		Anatomical projection that is composed of bone tissue.
http://purl.obolibrary.org/obo/UBERON_0004533	left testis	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A testis that is in the left side of the genitalia [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004534	right testis	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A testis that is in the right side of the genitalia [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004536	lymph vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.
http://purl.obolibrary.org/obo/UBERON_0004537	blood vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vascular network consisting of blood vessels.
http://purl.obolibrary.org/obo/UBERON_0004538	left kidney	http://purl.obolibrary.org/obo/UBERON_0002113	kidney		A kidney that is part of a left side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004539	right kidney	http://purl.obolibrary.org/obo/UBERON_0002113	kidney		A kidney that is part of a right side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004544	epididymis epithelium	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		The layer of secretory cells which lines the epididymis.
http://purl.obolibrary.org/obo/UBERON_0004548	left eye	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An eye that is part of a left side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004549	right eye	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An eye that is part of a right side of organism [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004552	digital artery	http://purl.obolibrary.org/obo/UBERON_0003514	limb blood vessel		An artery that is part of a digit [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004553	forelimb digital artery	http://purl.obolibrary.org/obo/UBERON_0004552	digital artery		A digital artery that is part of a forelimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004554	hindlimb digital artery	http://purl.obolibrary.org/obo/UBERON_0004552	digital artery		A digital artery that is part of a hindlimb [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004571	systemic arterial system	http://purl.obolibrary.org/obo/UBERON_0007798	vascular system		The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.
http://purl.obolibrary.org/obo/UBERON_0004572	arterial system	http://purl.obolibrary.org/obo/UBERON_0007798	vascular system		The part of the cardiovascular system consisting of all arteries.
http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.
http://purl.obolibrary.org/obo/UBERON_0004581	systemic venous system	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		The part of the venous system that drains the general body tissues[Kardong].
http://purl.obolibrary.org/obo/UBERON_0004582	venous system	http://purl.obolibrary.org/obo/UBERON_0007798	vascular system		The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions.
http://purl.obolibrary.org/obo/UBERON_0004590	sphincter muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.
http://purl.obolibrary.org/obo/UBERON_0004601	rib 1	http://purl.obolibrary.org/obo/UBERON_0002228	rib		The first rib of the rib cage.
http://purl.obolibrary.org/obo/UBERON_0004611	rib 12	http://purl.obolibrary.org/obo/UBERON_0002228	rib		In humans: The twelfth rib has a single articular facet on the head, which is of rather large size. It has no necks or tubercles, and is pointed at its anterior ends. The twelfth has angle nor costal groove; it is much shorter than the eleventh rib, and its head is inclined slightly downward. Sometimes the twelfth rib is even shorter than the first rib. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0004612	mammalian cervical vertebra 3	http://purl.obolibrary.org/obo/UBERON_0002413	cervical vertebra		The third of the seven cervical vertebrae[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004613	mammalian cervical vertebra 4	http://purl.obolibrary.org/obo/UBERON_0002413	cervical vertebra		The fourth of the seven cervical vertebrae[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004614	mammalian cervical vertebra 5	http://purl.obolibrary.org/obo/UBERON_0002413	cervical vertebra		The fifth of the seven cervical vertebrae[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004615	mammalian cervical vertebra 6	http://purl.obolibrary.org/obo/UBERON_0002413	cervical vertebra		The sixth of the seven cervical vertebrae[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004617	lumbar vertebra 1	http://purl.obolibrary.org/obo/UBERON_0002414	lumbar vertebra		The first lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004618	lumbar vertebra 2	http://purl.obolibrary.org/obo/UBERON_0002414	lumbar vertebra		The second lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004619	lumbar vertebra 3	http://purl.obolibrary.org/obo/UBERON_0002414	lumbar vertebra		The third lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004620	lumbar vertebra 4	http://purl.obolibrary.org/obo/UBERON_0002414	lumbar vertebra		The fourth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004621	lumbar vertebra 5	http://purl.obolibrary.org/obo/UBERON_0002414	lumbar vertebra		The fifth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].
http://purl.obolibrary.org/obo/UBERON_0004637	otic capsule	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		The capsule surrounding the inner ear mechanism.
http://purl.obolibrary.org/obo/UBERON_0004638	blood vessel endothelium	http://purl.obolibrary.org/obo/UBERON_0004852	cardiovascular system endothelium		An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart.
http://purl.obolibrary.org/obo/UBERON_0004639	renal afferent arteriole	http://purl.obolibrary.org/obo/UBERON_0003644	kidney arterial blood vessel		The blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism.
http://purl.obolibrary.org/obo/UBERON_0004641	spleen capsule	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		The connective tissue that surrounds the spleen.
http://purl.obolibrary.org/obo/UBERON_0004646	infraorbital artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The infraorbital artery is an artery in the head that runs in the maxilla, emerging through the infraorbital foramen, just under the orbit of the eye. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0004647	liver lobule	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein.
http://purl.obolibrary.org/obo/UBERON_0004649	sphenoid bone pterygoid process	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		The process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes.
http://purl.obolibrary.org/obo/UBERON_0004650	tongue keratinized epithelium	http://purl.obolibrary.org/obo/UBERON_0012329	keratinized stratified squamous epithelium		A keratinized stratified squamous epithelium that is part of a tongue.
http://purl.obolibrary.org/obo/UBERON_0004652	humerus diaphysis	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		The body or shaft of the humerus is almost cylindrical in the upper half of its extent, prismatic and flattened below, and has three borders and three surfaces.
http://purl.obolibrary.org/obo/UBERON_0004657	mandible condylar process	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		Articular part of the mandible bone.
http://purl.obolibrary.org/obo/UBERON_0004660	mandible coronoid process	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		A dorsal process on the lower jaw associated with muscle attachment. It may be formed by a separate coronoid bone or as a process of the dentary. In most living (and many extinct) mammals, the most dorsal of the three proximal processes of the jaw.
http://purl.obolibrary.org/obo/UBERON_0004663	aorta wall	http://purl.obolibrary.org/obo/UBERON_0035965	wall of blood vessel		An anatomical wall that is part of an aorta, enclosing the luminal space.
http://purl.obolibrary.org/obo/UBERON_0004664	aorta tunica adventitia	http://purl.obolibrary.org/obo/UBERON_0005734	tunica adventitia of blood vessel		The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers.
http://purl.obolibrary.org/obo/UBERON_0004665	muscular coat of seminal vesicle	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		A muscular coat that is part of a seminal vesicle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004666	interventricular septum membranous part	http://purl.obolibrary.org/obo/UBERON_0005983	heart layer		The membranous portion of the wall between the two lower chambers of the heart.
http://purl.obolibrary.org/obo/UBERON_0004667	interventricular septum muscular part	http://purl.obolibrary.org/obo/UBERON_0002385	muscle tissue		The muscular portion of the wall between the two lower chambers of the heart.
http://purl.obolibrary.org/obo/UBERON_0004668	fourth ventricle aperture	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		One of: the 4th ventricle median or lateral apertures.
http://purl.obolibrary.org/obo/UBERON_0004684	raphe nuclei	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane.
http://purl.obolibrary.org/obo/UBERON_0004688	costo-cervical trunk	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0004692	external naris epithelium	http://purl.obolibrary.org/obo/UBERON_0035036	naris epithelium		An epithelium that is part of an external naris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004695	arterial system smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004696	venous system smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004237	blood vessel smooth muscle		A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004698	vena cava endothelium	http://purl.obolibrary.org/obo/UBERON_0001919	endothelium of vein		An endothelium that is part of a vena cava [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004699	outflow tract endothelium	http://purl.obolibrary.org/obo/UBERON_0008307	heart endothelium		An endothelium that is part of a outflow tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004700	arterial system endothelium	http://purl.obolibrary.org/obo/UBERON_0004852	cardiovascular system endothelium		An endothelium that is part of an arterial system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004701	venous system endothelium	http://purl.obolibrary.org/obo/UBERON_0004852	cardiovascular system endothelium		An endothelium that is part of a venous system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004702	respiratory system blood vessel endothelium	http://purl.obolibrary.org/obo/UBERON_0004807	respiratory system epithelium		A blood vessel endothelium that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004704	bone fossa	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		A depression or hollow in a bone[WP].
http://purl.obolibrary.org/obo/UBERON_0004706	bulbus cordis	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches.
http://purl.obolibrary.org/obo/UBERON_0004708	paired limb/fin	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		An appendage that is part of an appendage girdle complex.
http://purl.obolibrary.org/obo/UBERON_0004709	pelvic appendage	http://purl.obolibrary.org/obo/UBERON_0004708	paired limb/fin		Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues.
http://purl.obolibrary.org/obo/UBERON_0004710	pectoral appendage	http://purl.obolibrary.org/obo/UBERON_0004708	paired limb/fin		Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.
http://purl.obolibrary.org/obo/UBERON_0004711	jugular vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava.
http://purl.obolibrary.org/obo/UBERON_0004713	corpus cavernosum penis	http://purl.obolibrary.org/obo/UBERON_0006609	corpus cavernosum		One of the columns of erectile tissue forming the dorsum and sides of the penis.
http://purl.obolibrary.org/obo/UBERON_0004714	septum pellucidum	http://purl.obolibrary.org/obo/UBERON_0000119	cell layer		A triangular double membrane, consisting of glial cells and fibers (Heimer, 1996) separating the anterior horns of the lateral ventricles of the brain. It is situated in the median plane and bounded by the corpus callosum and the body and columns of the fornix.
http://purl.obolibrary.org/obo/UBERON_0004715	annulus fibrosus disci intervertebralis	http://purl.obolibrary.org/obo/UBERON_0006444	annulus fibrosus		The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised.
http://purl.obolibrary.org/obo/UBERON_0004716	conceptus	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP].
http://purl.obolibrary.org/obo/UBERON_0004723	interlobular artery	http://purl.obolibrary.org/obo/UBERON_0003644	kidney arterial blood vessel		The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule.
http://purl.obolibrary.org/obo/UBERON_0004724	medial palpebral ligament	http://purl.obolibrary.org/obo/UBERON_0000211	ligament		The medial palpebral ligament (tendo oculi), about 4 mm. in length and 2 mm. in breadth, is attached to the frontal process of the maxilla in front of the lacrimal groove. Crossing the lacrimal sac, it divides into two parts, upper and lower, each attached to the medial end of the corresponding tarsus. As the ligament crosses the lacrimal sac, a strong aponeurotic is given off from its posterior surface; this expands over the sac, and is attached to the posterior lacrimal crest.
http://purl.obolibrary.org/obo/UBERON_0004727	cochlear nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A nerve in the head that carries signals from the cochlea of the inner ear to the brain. It is part of the vestibulocochlear nerve, the 8th cranial nerve which is found in higher vertebrates; the other portion of the 8th cranial nerve is the vestibular nerve which carries spatial orientation information from the semicircular canals. The cochlear nerve is a sensory nerve, one which conducts to the brain information about the environment, in this case acoustic energy impinging on the tympanic membrane. The cochlear nerve arises from within the cochlea and extends to the brainstem, where its fibers make contact with the cochlear nucleus, the next stage of neural processing in the auditory system[WP].
http://purl.obolibrary.org/obo/UBERON_0004731	neuromere	http://purl.obolibrary.org/obo/UBERON_0004732	segmental subdivision of nervous system		A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres).
http://purl.obolibrary.org/obo/UBERON_0004732	segmental subdivision of nervous system	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres.
http://purl.obolibrary.org/obo/UBERON_0004733	segmental subdivision of hindbrain	http://purl.obolibrary.org/obo/UBERON_0004732	segmental subdivision of nervous system		An organ subunit that is part of a hindbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004734	gastrula	http://purl.obolibrary.org/obo/UBERON_0000922	embryo		Organism at the gastrula stage.
http://purl.obolibrary.org/obo/UBERON_0004736	metanephric glomerulus	http://purl.obolibrary.org/obo/UBERON_0000074	renal glomerulus		Glomerulus of the mature vertebrate kidney, or metanephros.
http://purl.obolibrary.org/obo/UBERON_0004737	metanephric collecting duct	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		A collecting duct of renal tubule that is part of a metanephros [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004739	pronephric glomerulus	http://purl.obolibrary.org/obo/UBERON_0000074	renal glomerulus		The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.
http://purl.obolibrary.org/obo/UBERON_0004742	dentary	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians, extending to the whole lower jaw in mammals[VHOG,modified].
http://purl.obolibrary.org/obo/UBERON_0004753	scapulocoracoid	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Skeletal element that consists of the scapula and the coracoid[VSAO, modified].
http://purl.obolibrary.org/obo/UBERON_0004755	skeletal tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
http://purl.obolibrary.org/obo/UBERON_0004756	dermal skeletal element	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Dermis-derived entity that is made of skeletal tissue.
http://purl.obolibrary.org/obo/UBERON_0004760	gland of anal canal	http://purl.obolibrary.org/obo/UBERON_0003408	gland of digestive tract		A gland that is part of an anal canal [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004761	cartilaginous neurocranium	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP].
http://purl.obolibrary.org/obo/UBERON_0004763	endochondral bone tissue	http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue		Replacement bone tissue that forms within cartilage[VSAO, modified].
http://purl.obolibrary.org/obo/UBERON_0004764	intramembranous bone tissue	http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue		Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].
http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
http://purl.obolibrary.org/obo/UBERON_0004766	cranial bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		A bone that is part of a cranium.
http://purl.obolibrary.org/obo/UBERON_0004767	vomerine tooth	http://purl.obolibrary.org/obo/UBERON_0012070	palatal tooth		A tooth that is on the vomer.
http://purl.obolibrary.org/obo/UBERON_0004768	bone of lower jaw	http://purl.obolibrary.org/obo/UBERON_0012360	bone of jaw		Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular.
http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		Subdivision of long bone which forms the part of the bone between the two epiphyses, excluding the metaphyses[FMA,modified].
http://purl.obolibrary.org/obo/UBERON_0004770	articular system	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		Anatomical system that consists of all the joints of the body.
http://purl.obolibrary.org/obo/UBERON_0004771	posterior nasal aperture	http://purl.obolibrary.org/obo/UBERON_0010425	internal naris		Opening/conduit between the nasal cavity and the nasopharynx[AAO] The choanae are separated by the vomer[WP].
http://purl.obolibrary.org/obo/UBERON_0004772	eyelid tarsus	http://purl.obolibrary.org/obo/UBERON_0000094	membrane organ		The tarsi (tarsal plates) are two comparatively thick, elongated plates of dense connective tissue, about 2.5 cm. in length; one is found in each eyelid, and contributes to its form and support. They directly abut the lid margins.
http://purl.obolibrary.org/obo/UBERON_0004773	superior eyelid tarsus	http://purl.obolibrary.org/obo/UBERON_0004772	eyelid tarsus		An eyelid tarsus that is part of a upper eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004774	inferior eyelid tarsus	http://purl.obolibrary.org/obo/UBERON_0004772	eyelid tarsus		An eyelid tarsus that is part of a lower eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004777	respiratory system submucosa	http://purl.obolibrary.org/obo/UBERON_0000009	submucosa		A submucosa that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004778	larynx submucosa	http://purl.obolibrary.org/obo/UBERON_0004777	respiratory system submucosa		A submucosa that is part of a larynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004779	respiratory system lamina propria	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004780	gastrointestinal system lamina propria	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a gastrointestinal system.
http://purl.obolibrary.org/obo/UBERON_0004781	gallbladder lamina propria	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a gallbladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004782	gastrointestinal system serosa	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		A serous membrane that is part of a digestive system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004783	gallbladder serosa	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		A serous membrane that is part of a gallbladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004784	heart ventricle wall	http://purl.obolibrary.org/obo/UBERON_0037144	wall of heart		An anatomical wall that is part of a cardiac ventricle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004785	respiratory system mucosa	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		The mucous membrane lining the respiratory tract.
http://purl.obolibrary.org/obo/UBERON_0004786	gastrointestinal system mucosa	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a gastrointestinal system.
http://purl.obolibrary.org/obo/UBERON_0004789	larynx mucous gland	http://purl.obolibrary.org/obo/UBERON_0036225	respiratory system gland		A mucous gland that is part of a larynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004790	skin mucous gland	http://purl.obolibrary.org/obo/UBERON_0019319	exocrine gland of integumental system		A mucous gland that is part of the skin.
http://purl.obolibrary.org/obo/UBERON_0004791	thymus trabecula	http://purl.obolibrary.org/obo/UBERON_0000440	trabecula		The thymic connective tissue which extends into the parenchyma.
http://purl.obolibrary.org/obo/UBERON_0004792	secretion of endocrine pancreas	http://purl.obolibrary.org/obo/UBERON_0004795	pancreas secretion		A secretion that is part of a endocrine pancreas [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004793	secretion of exocrine pancreas	http://purl.obolibrary.org/obo/UBERON_0004795	pancreas secretion		A secretion that is part of a exocrine pancreas [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004794	esophagus secretion	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		A secretion that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004795	pancreas secretion	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		A secretion that is part of a pancreas [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004796	prostate gland secretion	http://purl.obolibrary.org/obo/UBERON_0006530	seminal fluid		A bodily secretion that is produced by the prostate gland.
http://purl.obolibrary.org/obo/UBERON_0004797	blood vessel layer	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia.
http://purl.obolibrary.org/obo/UBERON_0004798	respiratory system basal lamina	http://purl.obolibrary.org/obo/UBERON_0000482	basal lamina of epithelium		A basal lamina that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004799	trachea basal lamina	http://purl.obolibrary.org/obo/UBERON_0004798	respiratory system basal lamina		A basal lamina that is part of a respiratory airway [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004800	bronchus basal lamina	http://purl.obolibrary.org/obo/UBERON_0004799	trachea basal lamina		A basal lamina that is part of a bronchus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004801	cervix epithelium	http://purl.obolibrary.org/obo/UBERON_0006955	uterine epithelium		An epithelium that is part of a uterine cervix [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004802	respiratory tract epithelium	http://purl.obolibrary.org/obo/UBERON_0010499	pseudostratified ciliated columnar epithelium		The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.
http://purl.obolibrary.org/obo/UBERON_0004803	penis epithelium	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An epithelium that is part of a penis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004804	oviduct epithelium	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An epithelium that is part of a oviduct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004805	seminal vesicle epithelium	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		An epithelium that is part of a seminal vesicle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004806	vas deferens epithelium	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		An epithelium that is part of a vas deferens [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004807	respiratory system epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004808	gastrointestinal system epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a digestive system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004809	salivary gland epithelium	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		An epithelium that is part of a salivary gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004810	nephron tubule epithelium	http://purl.obolibrary.org/obo/UBERON_0004211	nephron epithelium		The cellular avascular layer of the renal tubule luminar surfaces.
http://purl.obolibrary.org/obo/UBERON_0004811	endometrium epithelium	http://purl.obolibrary.org/obo/UBERON_0006955	uterine epithelium		An epithelium that is part of an endometrium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004812	male prepuce epithelium	http://purl.obolibrary.org/obo/UBERON_0004803	penis epithelium		An epithelium that is part of a prepuce of penis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004813	seminiferous tubule epithelium	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		The stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule.
http://purl.obolibrary.org/obo/UBERON_0004814	upper respiratory tract epithelium	http://purl.obolibrary.org/obo/UBERON_0004802	respiratory tract epithelium		An epithelium that is part of a upper respiratory tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004815	lower respiratory tract epithelium	http://purl.obolibrary.org/obo/UBERON_0004802	respiratory tract epithelium		An epithelium that is part of a lower respiratory tract [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004816	larynx epithelium	http://purl.obolibrary.org/obo/UBERON_0004802	respiratory tract epithelium		An epithelium that is part of a larynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004817	lacrimal gland epithelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		An epithelium that is part of a lacrimal gland [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004819	kidney epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		The cellular avascular layer of the kidney luminar surfaces.
http://purl.obolibrary.org/obo/UBERON_0004820	bile duct epithelium	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		Any epithelium that lines one of the bile ducts.
http://purl.obolibrary.org/obo/UBERON_0004821	pulmonary alveolus epithelium	http://purl.obolibrary.org/obo/UBERON_0000487	simple squamous epithelium		The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO].
http://purl.obolibrary.org/obo/UBERON_0004822	extrahepatic bile duct epithelium	http://purl.obolibrary.org/obo/UBERON_0004820	bile duct epithelium		An epithelium that is part of a extrahepatic bile duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004823	intrahepatic bile duct epithelium	http://purl.obolibrary.org/obo/UBERON_0004820	bile duct epithelium		An epithelium that is part of a intrahepatic bile duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004827	thyroid gland medulla	http://purl.obolibrary.org/obo/UBERON_0000958	medulla of organ		A medulla that is part of a thyroid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004829	urethra skeletal muscle tissue	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a urethra [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004830	respiratory system skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004831	esophagus skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004832	anal region skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004833	lip skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004834	hepatic duct smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		Smooth muscle tissue in all or part of a hepatic duct.
http://purl.obolibrary.org/obo/UBERON_0004835	epididymis smooth muscle	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A portion of smooth muscle tissue that is part of a epididymis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004848	respiratory system arterial endothelium	http://purl.obolibrary.org/obo/UBERON_0004702	respiratory system blood vessel endothelium		An endothelium of artery that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004849	respiratory system venous endothelium	http://purl.obolibrary.org/obo/UBERON_0004702	respiratory system blood vessel endothelium		An endothelium of vein that is part of a respiratory system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004850	lymph node endothelium	http://purl.obolibrary.org/obo/UBERON_0001986	endothelium		An endothelium that is part of a lymph node [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004851	aorta endothelium	http://purl.obolibrary.org/obo/UBERON_0004700	arterial system endothelium		The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall.
http://purl.obolibrary.org/obo/UBERON_0004852	cardiovascular system endothelium	http://purl.obolibrary.org/obo/UBERON_0001986	endothelium		An endothelium that is part of the cardiovascular system.
http://purl.obolibrary.org/obo/UBERON_0004854	gastrointestinal system mesentery	http://purl.obolibrary.org/obo/UBERON_0004782	gastrointestinal system serosa		A mesentery that is part of a digestive system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004857	skeletal muscle connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		A connective tissue that surrounds a skeletal muscle tissue.
http://purl.obolibrary.org/obo/UBERON_0004859	eye gland	http://purl.obolibrary.org/obo/UBERON_0002530	gland		A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid.
http://purl.obolibrary.org/obo/UBERON_0004861	right lung alveolus	http://purl.obolibrary.org/obo/UBERON_0002299	alveolus of lung		An alveolus that is part of a right lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004862	left lung alveolus	http://purl.obolibrary.org/obo/UBERON_0002299	alveolus of lung		An alveolus that is part of a left lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004863	thoracic sympathetic nerve trunk	http://purl.obolibrary.org/obo/UBERON_0004295	sympathetic nerve trunk		A sympathetic nerve trunk that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004864	vasculature of retina	http://purl.obolibrary.org/obo/UBERON_0036302	vasculature of central nervous system plus retina		A vasculature that is part of a retina [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004867	orbital cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye.
http://purl.obolibrary.org/obo/UBERON_0004871	somatic layer of lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Layer of lateral plate mesoderm that forms the future body wall - underlies the ectoderm[WP].
http://purl.obolibrary.org/obo/UBERON_0004872	splanchnic layer of lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP].
http://purl.obolibrary.org/obo/UBERON_0004873	splanchnopleure	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP].
http://purl.obolibrary.org/obo/UBERON_0004874	somatopleure	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP].
http://purl.obolibrary.org/obo/UBERON_0004875	nephrogenic cord	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A portion of the urogenital ridge which is the source of much of the urinary system[WP].
http://purl.obolibrary.org/obo/UBERON_0004876	urogenital fold	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP].
http://purl.obolibrary.org/obo/UBERON_0004880	chordamesoderm	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The central region of trunk mesoderm. This tissue forms the notochord.
http://purl.obolibrary.org/obo/UBERON_0004883	lung mesenchyme	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The mass of tissue made up of mesenchymal cells in the lung.
http://purl.obolibrary.org/obo/UBERON_0004893	interalveolar septum	http://purl.obolibrary.org/obo/UBERON_0003037	septum		A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung.
http://purl.obolibrary.org/obo/UBERON_0004894	alveolar wall	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		A wall that contains the alveoli.
http://purl.obolibrary.org/obo/UBERON_0004895	alveolar smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004233	lower respiratory tract smooth muscle		Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus.
http://purl.obolibrary.org/obo/UBERON_0004902	urogenital sinus epithelium	http://purl.obolibrary.org/obo/UBERON_0009846	embryonic cloacal epithelium		The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra.
http://purl.obolibrary.org/obo/UBERON_0004904	neuron projection bundle connecting eye with brain	http://purl.obolibrary.org/obo/UBERON_0000122	neuron projection bundle		A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila.
http://purl.obolibrary.org/obo/UBERON_0004905	articulation	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts.
http://purl.obolibrary.org/obo/UBERON_0004906	ectodermal part of digestive tract	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		A portion of the gut that is derived from ectoderm.
http://purl.obolibrary.org/obo/UBERON_0004907	lower digestive tract	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition].
http://purl.obolibrary.org/obo/UBERON_0004908	upper digestive tract	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum.
http://purl.obolibrary.org/obo/UBERON_0004909	epithelium of gonad	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An epithelium surrounding a gonad.
http://purl.obolibrary.org/obo/UBERON_0004910	epithelium of male gonad	http://purl.obolibrary.org/obo/UBERON_0004909	epithelium of gonad		An epithelium surrounding a testis.
http://purl.obolibrary.org/obo/UBERON_0004911	epithelium of female gonad	http://purl.obolibrary.org/obo/UBERON_0004909	epithelium of gonad		An epithelium surrounding an ovary.
http://purl.obolibrary.org/obo/UBERON_0004914	duodenal papilla	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct.
http://purl.obolibrary.org/obo/UBERON_0004915	sphincter of hepatopancreatic ampulla	http://purl.obolibrary.org/obo/UBERON_0011185	gastrointestinal sphincter		Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP].
http://purl.obolibrary.org/obo/UBERON_0004916	anal sphincter	http://purl.obolibrary.org/obo/UBERON_0004590	sphincter muscle		A sphincter muscle that is part of a anal region.
http://purl.obolibrary.org/obo/UBERON_0004917	urethral sphincter	http://purl.obolibrary.org/obo/UBERON_0004590	sphincter muscle		A sphincter muscle surrounding the urethra.
http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		A proximal-distal subdivision of the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A part of a wall of an organ that forms a layer.
http://purl.obolibrary.org/obo/UBERON_0004924	submucosa of pharynx	http://purl.obolibrary.org/obo/UBERON_0018257	submucosa of digestive tract		The tissue underlying the tunica mucosa of the pharynx.
http://purl.obolibrary.org/obo/UBERON_0004925	submucosa of laryngopharynx	http://purl.obolibrary.org/obo/UBERON_0004924	submucosa of pharynx		A submucosa that is part of a hypopharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004926	submucosa of cystic duct	http://purl.obolibrary.org/obo/UBERON_0004938	submucosa of biliary tree		A submucosa that is part of a cystic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004931	submucosa of descending colon	http://purl.obolibrary.org/obo/UBERON_0003331	submucosa of colon		A submucosa that is part of a descending colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004932	submucosa of sigmoid colon	http://purl.obolibrary.org/obo/UBERON_0003331	submucosa of colon		A submucosa that is part of a sigmoid colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004934	submucosa of body of stomach	http://purl.obolibrary.org/obo/UBERON_0001200	submucosa of stomach		A submucosa that is part of a body of stomach [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004936	submucosa of pyloric antrum	http://purl.obolibrary.org/obo/UBERON_0004937	submucosa of pylorus		A submucosa that is part of a pyloric antrum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004937	submucosa of pylorus	http://purl.obolibrary.org/obo/UBERON_0001200	submucosa of stomach		A submucosa that is part of a pylorus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004938	submucosa of biliary tree	http://purl.obolibrary.org/obo/UBERON_0000009	submucosa		A submucosa that is part of a biliary tree [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004939	submucosa of common bile duct	http://purl.obolibrary.org/obo/UBERON_0004938	submucosa of biliary tree		A submucosa that is part of a common bile duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004940	submucosa of common hepatic duct	http://purl.obolibrary.org/obo/UBERON_0004938	submucosa of biliary tree		A submucosa that is part of a common hepatic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004941	submucosa of right hepatic duct	http://purl.obolibrary.org/obo/UBERON_0004938	submucosa of biliary tree		A submucosa that is part of a right hepatic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004942	submucosa of left hepatic duct	http://purl.obolibrary.org/obo/UBERON_0004938	submucosa of biliary tree		A submucosa that is part of a left hepatic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004943	submucosa of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0000009	submucosa		The submucous layer of the wall of the urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0004945	submucosa of neck of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0004943	submucosa of urinary bladder		A submucosa that is part of a neck of urinary bladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004946	submucosa of ileum	http://purl.obolibrary.org/obo/UBERON_0001205	submucosa of small intestine		A submucosa that is part of a ileum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004952	submucosa of bronchiole	http://purl.obolibrary.org/obo/UBERON_0004777	respiratory system submucosa		A submucosa that is part of a bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004980	mucosa of ureter	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a ureter [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004982	mucosa of epiglottis	http://purl.obolibrary.org/obo/UBERON_0004987	mucosa of laryngopharynx		A mucosa that is part of a epiglottis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004983	mucosa of vagina	http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa		A mucosa that is part of a vagina [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004984	mucosa of seminal vesicle	http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa		A mucosa that is part of a seminal vesicle [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004985	mucosa of ejaculatory duct	http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa		A mucosa that is part of a ejaculatory duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004986	mucosa of deferent duct	http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa		A mucosa that is part of a vas deferens [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004987	mucosa of laryngopharynx	http://purl.obolibrary.org/obo/UBERON_0000355	pharyngeal mucosa		A mucosa that is part of a hypopharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004988	mucosa of cystic duct	http://purl.obolibrary.org/obo/UBERON_0004999	mucosa of biliary tree		A mucosa that is part of a cystic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004992	mucosa of descending colon	http://purl.obolibrary.org/obo/UBERON_0000317	colonic mucosa		A mucosa that is part of a descending colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004993	mucosa of sigmoid colon	http://purl.obolibrary.org/obo/UBERON_0000317	colonic mucosa		A mucosa that is part of a sigmoid colon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004995	mucosa of body of stomach	http://purl.obolibrary.org/obo/UBERON_0001199	mucosa of stomach		A mucosa that is part of a body of stomach [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004997	mucosa of pyloric antrum	http://purl.obolibrary.org/obo/UBERON_0004998	mucosa of pylorus		A mucosa that is part of a pyloric antrum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004998	mucosa of pylorus	http://purl.obolibrary.org/obo/UBERON_0001199	mucosa of stomach		A mucosa that is part of a pylorus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0004999	mucosa of biliary tree	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a biliary tree [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005000	mucosa of common bile duct	http://purl.obolibrary.org/obo/UBERON_0004999	mucosa of biliary tree		A mucosa that is part of a common bile duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005001	mucosa of common hepatic duct	http://purl.obolibrary.org/obo/UBERON_0004999	mucosa of biliary tree		A mucosa that is part of a common hepatic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005002	mucosa of right hepatic duct	http://purl.obolibrary.org/obo/UBERON_0004999	mucosa of biliary tree		A mucosa that is part of a right hepatic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005003	mucosa of left hepatic duct	http://purl.obolibrary.org/obo/UBERON_0004999	mucosa of biliary tree		A mucosa that is part of a left hepatic duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005004	mucosa of right ureter	http://purl.obolibrary.org/obo/UBERON_0004980	mucosa of ureter		A mucosa that is part of a right ureter [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005005	mucosa of left ureter	http://purl.obolibrary.org/obo/UBERON_0004980	mucosa of ureter		A mucosa that is part of a left ureter [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005006	mucosa of renal pelvis	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a renal pelvis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005010	mucosa of neck of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0001259	mucosa of urinary bladder		A mucosa that is part of a neck of urinary bladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005011	mucosa of right fallopian tube	http://purl.obolibrary.org/obo/UBERON_0005048	mucosa of fallopian tube		A mucosa that is part of a right uterine tube [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005012	mucosa of left fallopian tube	http://purl.obolibrary.org/obo/UBERON_0005048	mucosa of fallopian tube		A mucosa that is part of a left uterine tube [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005013	mucosa of male urethra	http://purl.obolibrary.org/obo/UBERON_0012299	mucosa of urethra		A mucosa that is part of a male urethra [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005014	mucosa of female urethra	http://purl.obolibrary.org/obo/UBERON_0012299	mucosa of urethra		A mucosa that is part of a female urethra [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005017	mucosa of lacrimal sac	http://purl.obolibrary.org/obo/UBERON_0005043	mucosa of nasolacrimal duct		A mucosa that is part of a lacrimal sac [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005018	mucosa of nasal septum	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a nasal septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005019	mucosa of palate	http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa		A mucosa that is part of a palate [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005020	mucosa of tongue	http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa		A mucosa that is part of a tongue [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005021	mucosa of sphenoidal sinus	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a sphenoidal sinus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005022	mucosa of nasopharynx	http://purl.obolibrary.org/obo/UBERON_0000355	pharyngeal mucosa		A mucosa that is part of a nasopharynx [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005024	mucosa of soft palate	http://purl.obolibrary.org/obo/UBERON_0005019	mucosa of palate		A mucosa that is part of a soft palate [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005025	mucosa of uvula	http://purl.obolibrary.org/obo/UBERON_0005024	mucosa of soft palate		A mucosa that is part of a uvula [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005026	mucosa of middle ear	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a middle ear [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005027	mucosa of frontal sinus	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a frontal sinus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005028	mucosa of maxillary sinus	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a maxillary sinus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005030	mucosa of paranasal sinus	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that adjacent_to a paranasal sinus.
http://purl.obolibrary.org/obo/UBERON_0005031	mucosa of upper lip	http://purl.obolibrary.org/obo/UBERON_0036294	mucosa of lip		A mucosa that is part of a upper lip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005032	mucosa of lower lip	http://purl.obolibrary.org/obo/UBERON_0036294	mucosa of lip		A mucosa that is part of a lower lip [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005033	mucosa of gallbladder	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a gallbladder [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005039	mucosa of bronchiole	http://purl.obolibrary.org/obo/UBERON_0004785	respiratory system mucosa		A mucosa that is part of a bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005040	mucosa of terminal bronchiole	http://purl.obolibrary.org/obo/UBERON_0005039	mucosa of bronchiole		A mucosa that is part of a terminal bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005041	mucosa of respiratory bronchiole	http://purl.obolibrary.org/obo/UBERON_0005039	mucosa of bronchiole		A mucosa that is part of a respiratory bronchiole [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005042	inner epithelial layer of tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0009647	tympanic membrane epithelium		A portion of the tympanic cavity epithelium which makes up the outer (cuticular) layer of the tympanic membrane.
http://purl.obolibrary.org/obo/UBERON_0005043	mucosa of nasolacrimal duct	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a nasolacrimal duct [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005044	mucosa of pharyngotympanic tube	http://purl.obolibrary.org/obo/UBERON_0005026	mucosa of middle ear		A mucosa that is part of a pharyngotympanic tube [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005045	mucosa of ethmoidal sinus	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a ethmoid sinus [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005046	mucosa of hard palate	http://purl.obolibrary.org/obo/UBERON_0005019	mucosa of palate		A mucosa that is part of a hard palate [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005047	mucosa of vocal fold	http://purl.obolibrary.org/obo/UBERON_0001824	mucosa of larynx		A mucosa that is part of a vocal cord [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005048	mucosa of fallopian tube	http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa		A mucosa that is part of a fallopian tube [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005049	mucosa of infundibulum of uterine tube	http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa		A mucosa that is part of a uterine tube infundibulum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005051	mediastinum testis	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The mediastinum testis is a network of fibrous connective tissue that extends from the upper to near the lower extremity of the testis, and is wider above than below. From its front and sides numerous imperfect septa (trabeculæ) are given off, which radiate toward the surface of the organ, and are attached to the tunica albuginea. They divide the interior of the organ into a number of incomplete spaces, called lobules. These are somewhat cone-shaped, being broad at their bases at the surface of the gland, and becoming narrower as they converge to the mediastinum. The mediastinum supports the rete testis and blood vessels of the testis in their passage to and from the substance of the gland[WP].
http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		An organ part that is part of a long bone [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005056	external female genitalia	http://purl.obolibrary.org/obo/UBERON_0004176	external genitalia		An external genitalia that is part of a female reproductive system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005058	hemolymphoid system gland	http://purl.obolibrary.org/obo/UBERON_0002530	gland		A gland that is part of a hemolymphoid system [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005061	neural groove	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds.
http://purl.obolibrary.org/obo/UBERON_0005062	neural fold	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		One of the two elevated edges of the neural groove[GO,MP].
http://purl.obolibrary.org/obo/UBERON_0005064	left ventricular trabecular myocardium	http://purl.obolibrary.org/obo/UBERON_0004126	trabecular layer of ventricle		Missing definition for term UBERON:0005064. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0005066	right ventricular trabecular myocardium	http://purl.obolibrary.org/obo/UBERON_0004126	trabecular layer of ventricle		Missing definition for term UBERON:0005066. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0005068	neural rod	http://purl.obolibrary.org/obo/UBERON_0016879	future central nervous system		A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN].
http://purl.obolibrary.org/obo/UBERON_0005075	forebrain-midbrain boundary	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain.
http://purl.obolibrary.org/obo/UBERON_0005076	hindbrain-spinal cord boundary	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord.
http://purl.obolibrary.org/obo/UBERON_0005080	metanephric ureteric bud	http://purl.obolibrary.org/obo/UBERON_0000084	ureteric bud		The portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005081	ureter ureteric bud	http://purl.obolibrary.org/obo/UBERON_0000084	ureteric bud		The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO].
http://purl.obolibrary.org/obo/UBERON_0005082	tube lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A hole in a tube[GO].
http://purl.obolibrary.org/obo/UBERON_0005085	ectodermal placode	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO].
http://purl.obolibrary.org/obo/UBERON_0005086	hair follicle placode	http://purl.obolibrary.org/obo/UBERON_0011817	skin appendage placode		A bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts, the dermal condensate.
http://purl.obolibrary.org/obo/UBERON_0005087	tooth placode	http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode		An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud[GO].
http://purl.obolibrary.org/obo/UBERON_0005088	sebaceous gland placode	http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode		A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO].
http://purl.obolibrary.org/obo/UBERON_0005089	sweat gland placode	http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode		An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO].
http://purl.obolibrary.org/obo/UBERON_0005090	muscle structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].
http://purl.obolibrary.org/obo/UBERON_0005095	kidney rudiment	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Missing definition for term UBERON:0005095. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0005103	mesonephric epithelium	http://purl.obolibrary.org/obo/UBERON_0004819	kidney epithelium		An epithelium that is part of a mesonephros [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005106	metanephric tubule	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		A metanephric tubule is an epithelial tube that is part of the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005108	metanephric epithelium	http://purl.obolibrary.org/obo/UBERON_0004819	kidney epithelium		An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure[GO].
http://purl.obolibrary.org/obo/UBERON_0005109	metanephric smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		Any smooth muscle tissue that is part of a metanephros.
http://purl.obolibrary.org/obo/UBERON_0005110	metanephric nephron	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		A metanephric nephron is the functional unit of the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005111	metanephric pyramid	http://purl.obolibrary.org/obo/UBERON_0004200	kidney pyramid		Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts[GO].
http://purl.obolibrary.org/obo/UBERON_0005115	metanephric cortical collecting duct	http://purl.obolibrary.org/obo/UBERON_0004203	cortical collecting duct		The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex[GO].
http://purl.obolibrary.org/obo/UBERON_0005133	metanephric glomerulus vasculature	http://purl.obolibrary.org/obo/UBERON_0004190	renal glomerulus vasculature		The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO].
http://purl.obolibrary.org/obo/UBERON_0005134	metanephric nephron epithelium	http://purl.obolibrary.org/obo/UBERON_0005108	metanephric epithelium		The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005135	metanephric glomerular epithelium	http://purl.obolibrary.org/obo/UBERON_0005134	metanephric nephron epithelium		A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005136	metanephric glomerular endothelium	http://purl.obolibrary.org/obo/UBERON_0005135	metanephric glomerular epithelium		The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005137	metanephric capsule	http://purl.obolibrary.org/obo/UBERON_0002015	kidney capsule		The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage[GO].
http://purl.obolibrary.org/obo/UBERON_0005144	metanephric glomerular capillary	http://purl.obolibrary.org/obo/UBERON_0004212	glomerular capillary		This process pertains to the initial formation of a structure from unspecified parts[GO].
http://purl.obolibrary.org/obo/UBERON_0005145	metanephric comma-shaped body	http://purl.obolibrary.org/obo/UBERON_0004198	comma-shaped body		The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005146	metanephric nephron tubule	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005147	metanephric renal vesicle	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO].
http://purl.obolibrary.org/obo/UBERON_0005148	metanephric S-shaped body	http://purl.obolibrary.org/obo/UBERON_0004199	S-shaped body		The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005153	epithelial bud	http://purl.obolibrary.org/obo/UBERON_0005157	epithelial fold		A bud is a protrusion that forms from an epithelial sheet by localized folding.
http://purl.obolibrary.org/obo/UBERON_0005154	epithelial cord	http://purl.obolibrary.org/obo/UBERON_0000486	multilaminar epithelium		A cord of epithelial cells without a lumen and usually several cells thick.
http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		Any anatomical structure that is part of the reproductive system.
http://purl.obolibrary.org/obo/UBERON_0005157	epithelial fold	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelial sheet bent on a linear axis.
http://purl.obolibrary.org/obo/UBERON_0005158	parenchyma of central nervous system	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		The functional tissue of the central nervous system consisting of neurons and glial cells.
http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A structure consisting mainly of cell components, rather than complete cells.
http://purl.obolibrary.org/obo/UBERON_0005169	interstitial tissue	http://purl.obolibrary.org/obo/UBERON_0003891	stroma		Connective tissue between the cellular elements of a structure.
http://purl.obolibrary.org/obo/UBERON_0005171	hepatic duct	http://purl.obolibrary.org/obo/UBERON_0002394	bile duct		Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion).
http://purl.obolibrary.org/obo/UBERON_0005172	abdomen element	http://purl.obolibrary.org/obo/UBERON_0005173	abdominal segment element		An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.
http://purl.obolibrary.org/obo/UBERON_0005173	abdominal segment element	http://purl.obolibrary.org/obo/UBERON_0005177	trunk region element		An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.
http://purl.obolibrary.org/obo/UBERON_0005174	dorsal region element	http://purl.obolibrary.org/obo/UBERON_0000062	organ		An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.
http://purl.obolibrary.org/obo/UBERON_0005175	chest organ	http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ		An organ that is part of a chest [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005176	tooth enamel organ	http://purl.obolibrary.org/obo/UBERON_0034922	cell cluster		A circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth.
http://purl.obolibrary.org/obo/UBERON_0005177	trunk region element	http://purl.obolibrary.org/obo/UBERON_0000062	organ		An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.
http://purl.obolibrary.org/obo/UBERON_0005178	thoracic cavity element	http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ		An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.
http://purl.obolibrary.org/obo/UBERON_0005179	pelvic region element	http://purl.obolibrary.org/obo/UBERON_0005173	abdominal segment element		An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis.
http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ	http://purl.obolibrary.org/obo/UBERON_0005177	trunk region element		An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.
http://purl.obolibrary.org/obo/UBERON_0005184	hair medulla	http://purl.obolibrary.org/obo/UBERON_0000958	medulla of organ		Innermost layer of the hair shaft.
http://purl.obolibrary.org/obo/UBERON_0005185	renal medulla collecting duct	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		The portion of the collecting duct that resides in the renal medulla.
http://purl.obolibrary.org/obo/UBERON_0005192	deferent duct artery	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An artery in males that provides blood to the vas deferens. The artery usually arises from the anterior trunk of the superior vesical artery. It accompanies the vas deferens into the testis, where it anastomoses with the testicular artery. In this way it also supplies blood to the testis and epididymis. A small branch supplies the ureter[WP].
http://purl.obolibrary.org/obo/UBERON_0005193	ethmoidal artery	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		One of: anterior or posterior ethmoidal arteries.
http://purl.obolibrary.org/obo/UBERON_0005194	thoracic vein	http://purl.obolibrary.org/obo/UBERON_0003834	thoracic segment blood vessel		A vein that is part of a thorax [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005195	deferent duct vein	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A vein that is part of a vas deferens [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005196	spleen germinal center	http://purl.obolibrary.org/obo/UBERON_0010754	germinal center		A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen.
http://purl.obolibrary.org/obo/UBERON_0005199	cervical mammary gland	http://purl.obolibrary.org/obo/UBERON_0001911	mammary gland		A mammary gland that is part of a cervical region.
http://purl.obolibrary.org/obo/UBERON_0005200	thoracic mammary gland	http://purl.obolibrary.org/obo/UBERON_0005175	chest organ		A lactiferous gland that is located in the thoracic region/breast.
http://purl.obolibrary.org/obo/UBERON_0005203	trachea gland	http://purl.obolibrary.org/obo/UBERON_8410077	airway submucosal gland		A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen.
http://purl.obolibrary.org/obo/UBERON_0005204	larynx submucosa gland	http://purl.obolibrary.org/obo/UBERON_0036225	respiratory system gland		A gland that is part of a larynx submucosa [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005206	choroid plexus stroma	http://purl.obolibrary.org/obo/UBERON_0003891	stroma		Stromal matrix surrounding blood vessels within the choroid plexus.
http://purl.obolibrary.org/obo/UBERON_0005207	tonsil capsule	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		A capsule that is part of a tonsil [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005208	right atrium valve	http://purl.obolibrary.org/obo/UBERON_0003978	valve		A valve that is part of a right atrium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005211	renal medulla interstitium	http://purl.obolibrary.org/obo/UBERON_0005215	kidney interstitium		Tissue surrounding the loop of Henle in the renal medulla.
http://purl.obolibrary.org/obo/UBERON_0005212	Leydig cell region of testis	http://purl.obolibrary.org/obo/UBERON_0005169	interstitial tissue		The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS..
http://purl.obolibrary.org/obo/UBERON_0005214	inner renal medulla interstitium	http://purl.obolibrary.org/obo/UBERON_0005211	renal medulla interstitium		A portion of interstitial tissue that is part of a inner medulla of kidney [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005215	kidney interstitium	http://purl.obolibrary.org/obo/UBERON_0005169	interstitial tissue		The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes.
http://purl.obolibrary.org/obo/UBERON_0005217	midbrain subarachnoid space	http://purl.obolibrary.org/obo/UBERON_0039175	subarachnoid space of brain		A subarachnoid space that is part of a midbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005218	diencephalon subarachnoid space	http://purl.obolibrary.org/obo/UBERON_0039175	subarachnoid space of brain		A subarachnoid space that is part of a diencephalon [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005219	hindbrain subarachnoid space	http://purl.obolibrary.org/obo/UBERON_0039175	subarachnoid space of brain		A subarachnoid space that is part of a hindbrain [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005221	liver right lobe parenchyma	http://purl.obolibrary.org/obo/UBERON_0001280	liver parenchyma		A parenchyma that is part of a right lobe of liver [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005222	liver left lobe parenchyma	http://purl.obolibrary.org/obo/UBERON_0001280	liver parenchyma		A parenchyma that is part of a left lobe of liver [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005225	upper leg epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a hindlimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005226	pedal digit epithelium	http://purl.obolibrary.org/obo/UBERON_0000490	unilaminar epithelium		An epithelium that is part of a toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005227	manual digit epithelium	http://purl.obolibrary.org/obo/UBERON_0000490	unilaminar epithelium		An epithelium that is part of a finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005228	upper arm epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a forelimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005229	lower leg epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a lower leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005233	medial-nasal process ectoderm	http://purl.obolibrary.org/obo/UBERON_0014702	frontonasal process epithelium		An ectoderm that is part of a medial nasal prominence [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005234	optic eminence ectoderm	http://purl.obolibrary.org/obo/UBERON_0000924	ectoderm		An ectoderm that is part of a optic eminence [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005236	osseus labyrinth vestibule	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A small, oval, bony chamber of the labyrinth. The vestibule contains the utricle and saccule, organs which are part of the balancing apparatus of the ear.
http://purl.obolibrary.org/obo/UBERON_0005243	interventricular septum endocardium	http://purl.obolibrary.org/obo/UBERON_0002165	endocardium		An endocardium that is part of a interventricular septum [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005248	bulbus cordis myocardium	http://purl.obolibrary.org/obo/UBERON_0002349	myocardium		A myocardium that is part of a bulbus cordis [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005249	metanephric renal pelvis	http://purl.obolibrary.org/obo/UBERON_0001224	renal pelvis		A renal pelvis that is part of a metanephros.
http://purl.obolibrary.org/obo/UBERON_0005250	stomatodeum gland	http://purl.obolibrary.org/obo/UBERON_0002530	gland		A gland that is part of a stomodeum.
http://purl.obolibrary.org/obo/UBERON_0005251	yolk sac cavity	http://purl.obolibrary.org/obo/UBERON_0012466	extraembryonic cavity		An anatomical cavity that is part of a yolk sac [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005253	head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.
http://purl.obolibrary.org/obo/UBERON_0005254	upper leg mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003860	hindlimb mesenchyme		Mesenchyme that is part of a developing hindlimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005255	pedal digit mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010702	digit mesenchyme		Mesenchyme that is part of a developing toe [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005256	trunk mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Mesenchyme that is part of a developing trunk.
http://purl.obolibrary.org/obo/UBERON_0005257	manual digit mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010702	digit mesenchyme		Mesenchyme that is part of a developing finger [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005258	upper arm mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003859	forelimb mesenchyme		Mesenchyme that is part of a developing forelimb stylopod [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005259	lower leg mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003860	hindlimb mesenchyme		Mesenchyme that is part of a developing lower leg [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005268	renal cortex artery	http://purl.obolibrary.org/obo/UBERON_0003644	kidney arterial blood vessel		An artery that supplies the renal cortex.
http://purl.obolibrary.org/obo/UBERON_0005269	renal cortex vein	http://purl.obolibrary.org/obo/UBERON_0014401	renal venous blood vessel		Artery that receives blood from the renal cortex[MP, modified].
http://purl.obolibrary.org/obo/UBERON_0005270	renal cortex interstitium	http://purl.obolibrary.org/obo/UBERON_0005215	kidney interstitium		A compartment of the renal cortex situated between basement membranes of epithelia and vessels that contains two contiguous cellular networks in mutual contact, one formed by interstitial fibroblasts, the other by dendritic cells.
http://purl.obolibrary.org/obo/UBERON_0005273	nail bed	http://purl.obolibrary.org/obo/UBERON_0005275	dorsal skin of digit		Region of skin beneath the nail plate[WP].
http://purl.obolibrary.org/obo/UBERON_0005276	dorsal skin of finger	http://purl.obolibrary.org/obo/UBERON_0005275	dorsal skin of digit		A dorsal skin of digit that is part of a manual digit.
http://purl.obolibrary.org/obo/UBERON_0005277	dorsal skin of toe	http://purl.obolibrary.org/obo/UBERON_0005275	dorsal skin of digit		A dorsal skin of digit that is part of a pedal digit.
http://purl.obolibrary.org/obo/UBERON_0005278	nail bed of finger	http://purl.obolibrary.org/obo/UBERON_0005276	dorsal skin of finger		A nail bed that is part of a manual digit.
http://purl.obolibrary.org/obo/UBERON_0005279	nail bed of toe	http://purl.obolibrary.org/obo/UBERON_0005277	dorsal skin of toe		A nail bed that is part of a pedal digit.
http://purl.obolibrary.org/obo/UBERON_0005281	ventricular system of central nervous system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		A set of structures containing cerebrospinal fluid in the brain. It is continuous with the central canal of the spinal cord[WP].
http://purl.obolibrary.org/obo/UBERON_0005283	tela choroidea	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		A structure found in the walls of the ventricles of the brain, consisting of part of the meninges (pia mater in mammals) plus ependyma[cjm].
http://purl.obolibrary.org/obo/UBERON_0005286	tela choroidea of midbrain cerebral aqueduct	http://purl.obolibrary.org/obo/UBERON_0005283	tela choroidea		Tela choroidea that lines the tectal ventricle.
http://purl.obolibrary.org/obo/UBERON_0005287	tela choroidea of fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0005283	tela choroidea		Tela chorioidea that lines the fourth ventricle[ZFA]. The tela chorioidea of the fourth ventricle is the name applied to the triangular fold of pia mater which is carried upward between the cerebellum and the medulla oblongata. It consists of two layers, which are continuous with each other in front, and are more or less adherent throughout: The posterior layer covers the antero-inferior surface of the cerebellum. The anterior layer is applied to the structures which form the lower part of the roof of the ventricle, and is continuous inferiorly with the pia mater on the inferior peduncles and closed part of the medulla[WP].
http://purl.obolibrary.org/obo/UBERON_0005288	tela choroidea of third ventricle	http://purl.obolibrary.org/obo/UBERON_0005283	tela choroidea		Tela chorioidea that lines the third ventricle[ZFA]. The part of the choroid plexus in relation to the body of the ventricle forms the vascular fringed margin of a triangular process of pia mater, named the tela chorioidea of the third ventricle, and projects from under cover of the lateral edge of the fornix. Blood is supplied by branches from the superior cerebellar artery[WP].
http://purl.obolibrary.org/obo/UBERON_0005289	tela choroidea of telencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0005283	tela choroidea		Tela chorioidea that lines the telencephalic ventricle.
http://purl.obolibrary.org/obo/UBERON_0005290	myelencephalon	http://purl.obolibrary.org/obo/UBERON_0004733	segmental subdivision of hindbrain		The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].
http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		A portion of tissue that is part of an embryo.
http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo.
http://purl.obolibrary.org/obo/UBERON_0005294	gonadal ridge	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary.
http://purl.obolibrary.org/obo/UBERON_0005295	sex cord	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female.
http://purl.obolibrary.org/obo/UBERON_0005296	ovary sex cord	http://purl.obolibrary.org/obo/UBERON_0005295	sex cord		Structures that develop from sex cords in the female. After further development they become the ovarian follicles.
http://purl.obolibrary.org/obo/UBERON_0005297	testis sex cord	http://purl.obolibrary.org/obo/UBERON_0005295	sex cord		The testis cords are precursors to the rete testis. They play several different roles in the development of the male genitals[WP].
http://purl.obolibrary.org/obo/UBERON_0005298	skin of clitoris	http://purl.obolibrary.org/obo/UBERON_8480029	skin of external genitalia		A zone of skin that is part of a clitoris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0005299	prepuce of clitoris	http://purl.obolibrary.org/obo/UBERON_0011374	prepuce		A retractable double-layered fold of skin and mucous membrane that covers the clitoral glans.
http://purl.obolibrary.org/obo/UBERON_0005305	thyroid follicle	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Discrete, cystlike units of the thyroid gland that are lined with cuboidal epithelium and are filled with a colloid substance, about 30 to each lobule[BTO].
http://purl.obolibrary.org/obo/UBERON_0005309	pronephric nephron	http://purl.obolibrary.org/obo/UBERON_0001285	nephron		A pronephric nephron is the functional unit of the pronephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005310	pronephric nephron tubule	http://purl.obolibrary.org/obo/UBERON_0001231	nephron tubule		The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct[GO].
http://purl.obolibrary.org/obo/UBERON_0005311	mammary placode	http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode		The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper[GO].
http://purl.obolibrary.org/obo/UBERON_0005316	endocardial endothelium	http://purl.obolibrary.org/obo/UBERON_0008307	heart endothelium		The endothelial lining of the endocardium.
http://purl.obolibrary.org/obo/UBERON_0005317	pulmonary artery endothelium	http://purl.obolibrary.org/obo/UBERON_0001917	endothelium of artery		An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO].
http://purl.obolibrary.org/obo/UBERON_0005319	mesonephric collecting duct	http://purl.obolibrary.org/obo/UBERON_0001232	collecting duct of renal tubule		The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder[GO].
http://purl.obolibrary.org/obo/UBERON_0005321	mesonephric smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		Missing definition for term UBERON:0005321. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0005322	mesonephric nephron	http://purl.obolibrary.org/obo/UBERON_0001285	nephron		A nephron that is part of a mesonephros.
http://purl.obolibrary.org/obo/UBERON_0005323	mesonephric mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005325	mesonephric glomerulus	http://purl.obolibrary.org/obo/UBERON_0000074	renal glomerulus		The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005326	mesonephric glomerulus vasculature	http://purl.obolibrary.org/obo/UBERON_0004190	renal glomerulus vasculature		The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus[GO].
http://purl.obolibrary.org/obo/UBERON_0005327	mesonephric glomerular epithelium	http://purl.obolibrary.org/obo/UBERON_0005330	mesonephric nephron epithelium		A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005328	mesonephric comma-shaped body	http://purl.obolibrary.org/obo/UBERON_0004198	comma-shaped body		The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005330	mesonephric nephron epithelium	http://purl.obolibrary.org/obo/UBERON_0005103	mesonephric epithelium		The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005331	mesonephric renal vesicle	http://purl.obolibrary.org/obo/UBERON_0005103	mesonephric epithelium		The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO].
http://purl.obolibrary.org/obo/UBERON_0005332	mesonephric S-shaped body	http://purl.obolibrary.org/obo/UBERON_0004199	S-shaped body		The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO].
http://purl.obolibrary.org/obo/UBERON_0005333	mammary bud	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		A bulb of epithelial cells that forms from the mammary placode that develops into the mammary gland.
http://purl.obolibrary.org/obo/UBERON_0005334	oral lamina propria	http://purl.obolibrary.org/obo/UBERON_0000030	lamina propria		A lamina propria that is part of a mucosa of oral region.
http://purl.obolibrary.org/obo/UBERON_0005337	outflow tract of ventricle	http://purl.obolibrary.org/obo/UBERON_0004145	outflow tract		A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP].
http://purl.obolibrary.org/obo/UBERON_0005338	outflow tract aortic component	http://purl.obolibrary.org/obo/UBERON_0004145	outflow tract		An outflow tract that is part of a aorta.
http://purl.obolibrary.org/obo/UBERON_0005340	dorsal telencephalic commissure	http://purl.obolibrary.org/obo/UBERON_0019294	commissure of telencephalon		A fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure[MP].
http://purl.obolibrary.org/obo/UBERON_0005341	ventral commissure	http://purl.obolibrary.org/obo/UBERON_0019294	commissure of telencephalon		The fiber tracts that connect the ventral region of the two cerebral hemispheres and span the longitudinal fissure, including the anterior and the habenular commissures[MP].
http://purl.obolibrary.org/obo/UBERON_0005343	cortical plate	http://purl.obolibrary.org/obo/UBERON_0014950	layer of developing cerebral cortex		The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP].
http://purl.obolibrary.org/obo/UBERON_0005358	ventricle of nervous system	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord.
http://purl.obolibrary.org/obo/UBERON_0005362	vagus X ganglion	http://purl.obolibrary.org/obo/UBERON_0009127	epibranchial ganglion		The group of sensory neuron cell bodies associated with the vagus nerve.
http://purl.obolibrary.org/obo/UBERON_0005363	inferior vagus X ganglion	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve).
http://purl.obolibrary.org/obo/UBERON_0005366	olfactory lobe	http://purl.obolibrary.org/obo/UBERON_0016526	lobe of cerebral hemisphere		The lobe at the anterior part of each cerebral hemisphere, responsible for olfactory functions.
http://purl.obolibrary.org/obo/UBERON_0005373	spinal cord dorsal column	http://purl.obolibrary.org/obo/UBERON_0016550	spinal cord column		The wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception.
http://purl.obolibrary.org/obo/UBERON_0005375	spinal cord ventral column	http://purl.obolibrary.org/obo/UBERON_0016550	spinal cord column		The area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure.
http://purl.obolibrary.org/obo/UBERON_0005376	olfactory bulb external plexiform layer	http://purl.obolibrary.org/obo/UBERON_0009950	olfactory bulb plexiform layer		Cytoarchitectural part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer. The EPL is mostly neuropil composed almost entirely of mitral and tulfted cell dendrites and granule cell dendrites and their synaptic inputs.
http://purl.obolibrary.org/obo/UBERON_0005378	olfactory bulb granule cell layer	http://purl.obolibrary.org/obo/UBERON_0004001	olfactory bulb layer		The granule cell layer contains multiple small round neurons that lack axons. Long dendritic processes of the neurons reach the more superficial layers and inhibit mitral cells and tufted cells. Small distal processes make contacts with the exiting mitral cell axons.
http://purl.obolibrary.org/obo/UBERON_0005382	dorsal striatum	http://purl.obolibrary.org/obo/UBERON_0011300	gray matter of telencephalon		Dorsal components of the striatum comprising the caudate nucleus and the putamen, in species that have distinct nuclei; the caudoputamen in species which don't.
http://purl.obolibrary.org/obo/UBERON_0005383	caudate-putamen	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		Regional part of telencephalon in some species, e.g., rodent, equivalent to the dorsal striatum (caudate nucleus and putamen). Unlike the dorsal striatum of primates, for example, the caudoputamen is not split into separate nuclei by the fibers of the internal capsule. Rather, the internal capsule splits into fiber bundles which course through the structure.
http://purl.obolibrary.org/obo/UBERON_0005384	nasal cavity epithelium	http://purl.obolibrary.org/obo/UBERON_0019306	nose epithelium		An epithelium that lines the nasal cavity.
http://purl.obolibrary.org/obo/UBERON_0005388	photoreceptor array	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		An array of photoreceptors and any supporting cells found in an eye.
http://purl.obolibrary.org/obo/UBERON_0005389	transparent eye structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array.
http://purl.obolibrary.org/obo/UBERON_0005397	brain arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0003547	brain meninx		An arachnoid mater that surrounds a brain.
http://purl.obolibrary.org/obo/UBERON_0005398	female reproductive gland	http://purl.obolibrary.org/obo/UBERON_0003937	reproductive gland		A sex gland that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0005399	male reproductive gland	http://purl.obolibrary.org/obo/UBERON_0003937	reproductive gland		A sex gland that is part of a male reproductive system.
http://purl.obolibrary.org/obo/UBERON_0005400	telencephalon arachnoid mater	http://purl.obolibrary.org/obo/UBERON_0003556	forebrain arachnoid mater		An arachnoid mater that is part of a telencephalon.
http://purl.obolibrary.org/obo/UBERON_0005401	cerebral hemisphere gray matter	http://purl.obolibrary.org/obo/UBERON_0011300	gray matter of telencephalon		A gray matter that is part of a cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0005402	philtrum	http://purl.obolibrary.org/obo/UBERON_0006846	surface groove		The vertical groove found on the median line of the upper lip, extending to the nose.
http://purl.obolibrary.org/obo/UBERON_0005403	ventral striatum	http://purl.obolibrary.org/obo/UBERON_0011300	gray matter of telencephalon		A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info).
http://purl.obolibrary.org/obo/UBERON_0005404	frontonasal suture	http://purl.obolibrary.org/obo/UBERON_0009198	craniofacial suture		A suture between frontal and nasal bones.
http://purl.obolibrary.org/obo/UBERON_0005407	sublingual ganglion	http://purl.obolibrary.org/obo/UBERON_0001808	parasympathetic ganglion		The small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland.
http://purl.obolibrary.org/obo/UBERON_0005408	circumventricular organ	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow.
http://purl.obolibrary.org/obo/UBERON_0005410	cartilaginous otic capsule	http://purl.obolibrary.org/obo/UBERON_0004637	otic capsule		An otic capsule endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0005411	bony otic capsule	http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone		The cartilage or bony capsule surrounding the inner ear mechanism.
http://purl.obolibrary.org/obo/UBERON_0005412	optic fissure	http://purl.obolibrary.org/obo/UBERON_0006846	surface groove		Groove that is in the developing ventral optic cup and through which blood vessels pass to the enclosed mesenchyme[ZFA]. a ventral fissure in the developing optic cup through which blood vessels pass to the enclosed mesenchyme[Free online medical dictionary].
http://purl.obolibrary.org/obo/UBERON_0005413	spinocerebellar tract	http://purl.obolibrary.org/obo/UBERON_0001018	axon tract		This tract conveys interoceptive, proprioceptive, and exteroceptive information from the body's internal organs, and from the trunk, extremities, and neck region to the Cerebellum.
http://purl.obolibrary.org/obo/UBERON_0005417	forelimb bud	http://purl.obolibrary.org/obo/UBERON_0005419	pectoral appendage bud		A limb bud that develops into a forelimb.
http://purl.obolibrary.org/obo/UBERON_0005418	hindlimb bud	http://purl.obolibrary.org/obo/UBERON_0005420	pelvic appendage bud		A limb bud that develops into a hindlimb.
http://purl.obolibrary.org/obo/UBERON_0005419	pectoral appendage bud	http://purl.obolibrary.org/obo/UBERON_0004357	paired limb/fin bud		A limb bud that develops into a forelimb or pectoral fin.
http://purl.obolibrary.org/obo/UBERON_0005420	pelvic appendage bud	http://purl.obolibrary.org/obo/UBERON_0004357	paired limb/fin bud		A limb bud that develops into a hindlimb or pelvic fin.
http://purl.obolibrary.org/obo/UBERON_0005421	pectoral appendage apical ectodermal ridge	http://purl.obolibrary.org/obo/UBERON_0004356	apical ectodermal ridge		An apical ectodermal ridge that is part of a pectoral appendage bud.
http://purl.obolibrary.org/obo/UBERON_0005422	pelvic appendage apical ectodermal ridge	http://purl.obolibrary.org/obo/UBERON_0004356	apical ectodermal ridge		An apical ectodermal ridge that is part of a pelvic appendage bud.
http://purl.obolibrary.org/obo/UBERON_0005424	presumptive retinal pigmented epithelium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Portion of tissue that is the outer layer of the optic cup and will become the retinal pigmented epithelium.
http://purl.obolibrary.org/obo/UBERON_0005425	presumptive neural retina	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Portion of tissue that is the inner layer of the optic cup and will become the neural retina.
http://purl.obolibrary.org/obo/UBERON_0005426	lens vesicle	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Portion of tissue that gives rise to the lens.
http://purl.obolibrary.org/obo/UBERON_0005427	corneal primordium	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.
http://purl.obolibrary.org/obo/UBERON_0005428	vagal neural crest	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA].
http://purl.obolibrary.org/obo/UBERON_0005430	ansa cervicalis	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A loop of nerves that are part of the cervical plexus that lies superficial to the internal jugular vein in the carotid sheath. Branches from the ansa cervicalis innervate three of the four infrahyoid muscles, including the sternohyoid muscle, the sternothyroid muscle, and the omohyoid muscle.
http://purl.obolibrary.org/obo/UBERON_0005432	aortic sac	http://purl.obolibrary.org/obo/UBERON_0003498	heart blood vessel		The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates.
http://purl.obolibrary.org/obo/UBERON_0005436	common hepatic artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine), pancreas, and gall bladder. It arises from the celiac artery and has the following branches: the hepatic artery proper, the gastroduodenal artery and the right gastric artery.
http://purl.obolibrary.org/obo/UBERON_0005438	coronary sinus	http://purl.obolibrary.org/obo/UBERON_0003920	venous blood vessel		The short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice.
http://purl.obolibrary.org/obo/UBERON_0005440	ductus arteriosus	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		A fetal blood vessel connecting the pulmonary artery with the descending aorta[MESH]. In the developing fetus, the ductus arteriosus is a shunt connecting the pulmonary artery to the aortic arch. It allows most of the blood from the right ventricle to bypass the fetus' fluid-filled lungs, protecting the lungs from being overworked and allowing the left ventricle to strengthen. There are two other fetal shunts, the ductus venosus and the foramen ovale[MP]. the fetal vessel that connects the left pulmonary artery with the descending aorta; the ductus arteriosus normally regresses into a fibrous cord, the ligamentum arteriousum after birth[MP].
http://purl.obolibrary.org/obo/UBERON_0005442	abdominal external oblique muscle	http://purl.obolibrary.org/obo/UBERON_0035032	abdominal oblique muscle		The lateral abdominal wall muscle that is the most superficial, immediately superficial to the internal oblique.
http://purl.obolibrary.org/obo/UBERON_0005445	segment of pes	http://purl.obolibrary.org/obo/UBERON_0012139	segment of autopod		A segment of autopod that is part of a pes.
http://purl.obolibrary.org/obo/UBERON_0005446	foramen rotundum	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.
http://purl.obolibrary.org/obo/UBERON_0005451	segment of manus	http://purl.obolibrary.org/obo/UBERON_0012139	segment of autopod		A segment of autopod that is part of a manus.
http://purl.obolibrary.org/obo/UBERON_0005454	abdominal internal oblique muscle	http://purl.obolibrary.org/obo/UBERON_0035032	abdominal oblique muscle		The lateral abdominal wall muscle that is deep to the external oblique and superficial to the transversus.
http://purl.obolibrary.org/obo/UBERON_0005457	left thymus lobe	http://purl.obolibrary.org/obo/UBERON_0005483	thymus lobe		A thymus lobe that is in the left side of a thymus.
http://purl.obolibrary.org/obo/UBERON_0005460	left vitelline vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A vitelline vein that is in the left side of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0005461	levator scapulae muscle	http://purl.obolibrary.org/obo/UBERON_0034908	scapular muscle		An axial muscle that originates in the cervical vertebraae inserts on the scapula.
http://purl.obolibrary.org/obo/UBERON_0005462	lower back	http://purl.obolibrary.org/obo/UBERON_0009569	subdivision of trunk		Subdivision of abdominal segment of trunk which in humans is demarcated from the front of the abdomen by the posterior surface of the anterior layer of the thoracolumbar fascia and the anterior surface of the lumbar vertebral column; together with the front of the abdomen, it constitutes the abdomen[Modified from FMA].
http://purl.obolibrary.org/obo/UBERON_0005463	subcapsular sinus of lymph node	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A space between the capsule and the cortex which allows the free movement of lymphatic fluid and so contains a sparsity of lymphocytes. It is continuous with the similar lymph sinuses that flank the trabeculae.
http://purl.obolibrary.org/obo/UBERON_0005465	obturator nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		The obturator nerve arises from the ventral divisions of the second, third, and fourth lumbar nerves; the branch from the third is the largest, while that from the second is often very small.
http://purl.obolibrary.org/obo/UBERON_0005467	platysma	http://purl.obolibrary.org/obo/UBERON_0008876	hypodermis skeletal muscle layer		The platysma is a pharyngeal arch 2 muscle and a superficial facial muscle that participates in oral/pharyngeal behaviors and is innervated by the cervical branch of the facial nerve. It attaches to the mandible and it attaches to the skin of the head, neck, and thoracic region where it is found superficial to the clavicle. Burrows et al. (2011) argue that in hylobatids (and, presumably, other primates) the platysma in the region of the modiolus represents both the cervicale and myoides muscles.
http://purl.obolibrary.org/obo/UBERON_0005469	right thymus lobe	http://purl.obolibrary.org/obo/UBERON_0005483	thymus lobe		A thymus lobe that is in the right side of a thymus.
http://purl.obolibrary.org/obo/UBERON_0005472	right vitelline vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A vitelline vein that is in the right side of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0005473	sacral region	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		A subdivision of an organism along the anterior-posterior axis in the pelvic region immediately posterior to the lumbar region and anterior to the caudal region. Sometimes an intermediate region is defined between the sacral and caudal.
http://purl.obolibrary.org/obo/UBERON_0005475	sigmoid sinus	http://purl.obolibrary.org/obo/UBERON_0017635	paired venous dural sinus		A portion of the lateral venous sinus, bulging prominently into the mastoid cavity, that serves as a principal conduit by which blood leaves the cranium[EPIC]. The sigmoid is drained by the internal jugular vein.
http://purl.obolibrary.org/obo/UBERON_0005476	spinal nerve trunk	http://purl.obolibrary.org/obo/UBERON_0002464	nerve trunk		Trunk part of spinal nerve, where dorsal and ventral roots meet to form the spinal nerve, before branching off to dorsal and ventral rami.
http://purl.obolibrary.org/obo/UBERON_0005478	sulcus limitans of neural tube	http://purl.obolibrary.org/obo/UBERON_0006846	surface groove		A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD].
http://purl.obolibrary.org/obo/UBERON_0005483	thymus lobe	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Either of the two lateral lobes that constitute the thymus.
http://purl.obolibrary.org/obo/UBERON_0005484	tricuspid valve leaflet	http://purl.obolibrary.org/obo/UBERON_0011741	cardiac valve leaflet		A valve leaflet that is part of a tricuspid valve.
http://purl.obolibrary.org/obo/UBERON_0005486	venous dural sinus	http://purl.obolibrary.org/obo/UBERON_0006615	venous sinus		A venous channel found between layers of dura mater in the brain. Receives blood from internal and external veins of the brain, receive cerebrospinal fluid (CSF) from the subarachnoid space, and ultimately empty into the internal jugular vein.
http://purl.obolibrary.org/obo/UBERON_0005487	vitelline vein	http://purl.obolibrary.org/obo/UBERON_0013140	systemic vein		The paired veins that carry blood from the yolk sac back to the embryo.
http://purl.obolibrary.org/obo/UBERON_0005491	glossopharyngeal neural crest	http://purl.obolibrary.org/obo/UBERON_0003099	cranial neural crest		Cranial neural crest which gives rise to the glossopharyngeal ganglion.
http://purl.obolibrary.org/obo/UBERON_0005492	hyaloid vessel	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		A blood vessel that is associated with the lens. In mammals, this is transient and normally nourishes the retina, immature lens and primary vitreous of the developing eye.
http://purl.obolibrary.org/obo/UBERON_0005493	hyoid muscle	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		One of a group of muscles used in mastication and swallowing. These muscles are attached to the hyoid bone, which is suspended in the neck and forms the base of the tongue and larynx. The muscles are divided into suprahyoid (superior) or infrahyoid (inferior) groups relative to the bone[WP, generalized].
http://purl.obolibrary.org/obo/UBERON_0005496	neural tube lateral wall	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		Portion of tissue on the side of the lumen of the neural tube.
http://purl.obolibrary.org/obo/UBERON_0005498	primitive heart tube	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
http://purl.obolibrary.org/obo/UBERON_0005499	rhombomere 1	http://purl.obolibrary.org/obo/UBERON_0001892	rhombomere		Hindbrain segment or neuromere 1.
http://purl.obolibrary.org/obo/UBERON_0005501	rhombomere lateral wall	http://purl.obolibrary.org/obo/UBERON_0005496	neural tube lateral wall		A neural tube lateral wall that is part of a rhombomere.
http://purl.obolibrary.org/obo/UBERON_0005562	thymus primordium	http://purl.obolibrary.org/obo/UBERON_0003351	pharyngeal epithelium		A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID].
http://purl.obolibrary.org/obo/UBERON_0005563	trigeminal neural crest	http://purl.obolibrary.org/obo/UBERON_0007530	migrating mesenchyme population		Cranial neural crest which gives rise to the trigeminal ganglion.
http://purl.obolibrary.org/obo/UBERON_0005564	gonad primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		Portion of tissue that gives rise to the immature gonad.
http://purl.obolibrary.org/obo/UBERON_0005565	facio-acoustic neural crest	http://purl.obolibrary.org/obo/UBERON_0014387	mesenchyme derived from neural crest		Cranial neural crest that gives rise to the facio-acoustic ganglion.
http://purl.obolibrary.org/obo/UBERON_0005567	rhombomere 1 lateral wall	http://purl.obolibrary.org/obo/UBERON_0005501	rhombomere lateral wall		A rhombomere lateral wall that is part of a rhombomere 1.
http://purl.obolibrary.org/obo/UBERON_0005568	rhombomere 1 roof plate	http://purl.obolibrary.org/obo/UBERON_0005502	rhombomere roof plate		A rhombomere roof plate that is part of a rhombomere 1.
http://purl.obolibrary.org/obo/UBERON_0005594	head somite	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Somite located in the head region, caudal to the otic vesicle.
http://purl.obolibrary.org/obo/UBERON_0005597	lung primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum.
http://purl.obolibrary.org/obo/UBERON_0005598	trunk somite	http://purl.obolibrary.org/obo/UBERON_0002329	somite		A somite that is part of a trunk.
http://purl.obolibrary.org/obo/UBERON_0005609	iliac artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		Any of the arteries that arise from a bifurcation of the aorta supplying the pelvic or abdomen. Examples: Common iliac artery, External iliac artery, Internal iliac artery.
http://purl.obolibrary.org/obo/UBERON_0005611	inner canthus	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A corner of the medial (inner) part of an eye.
http://purl.obolibrary.org/obo/UBERON_0005614	lens anterior epithelium	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex.
http://purl.obolibrary.org/obo/UBERON_0005616	mesenteric artery	http://purl.obolibrary.org/obo/UBERON_0012254	abdominal aorta artery		Arteries which arise from the abdominal aorta and distribute to most of the intestines.
http://purl.obolibrary.org/obo/UBERON_0005617	mesenteric vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that returns blood from the intestines.
http://purl.obolibrary.org/obo/UBERON_0005619	secondary palatal shelf	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		The outgrowths of the embryonic maxillary prominences that come together during prenatal development to form the secondary palate.
http://purl.obolibrary.org/obo/UBERON_0005623	semi-lunar valve	http://purl.obolibrary.org/obo/UBERON_0000946	cardiac valve		The valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk.
http://purl.obolibrary.org/obo/UBERON_0005624	suprarenal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		Artery that supplies blood to the adrenal glands.
http://purl.obolibrary.org/obo/UBERON_0005625	tubotympanic recess lumen	http://purl.obolibrary.org/obo/UBERON_0007473	lumen of epithelial sac		The cavity formed by the tubotympanic recess epithelium.
http://purl.obolibrary.org/obo/UBERON_0005626	ventral mesogastrium	http://purl.obolibrary.org/obo/UBERON_0003281	mesentery of stomach		Portion of ventral mesentery closest to the stomach.
http://purl.obolibrary.org/obo/UBERON_0005629	vascular plexus	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vascular network formed by frequent anastomoses between the blood vessels (arteries or veins) of a part.
http://purl.obolibrary.org/obo/UBERON_0005631	extraembryonic membrane	http://purl.obolibrary.org/obo/UBERON_0000158	membranous layer		Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo.
http://purl.obolibrary.org/obo/UBERON_0005637	pyloric region epithelium	http://purl.obolibrary.org/obo/UBERON_0001276	epithelium of stomach		An epithelium that is part of a pylorus.
http://purl.obolibrary.org/obo/UBERON_0005638	anterior chamber epithelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		An epithelium that is part of a anterior chamber of eyeball.
http://purl.obolibrary.org/obo/UBERON_0005645	manual digit 2 epithelium	http://purl.obolibrary.org/obo/UBERON_0005227	manual digit epithelium		An epithelium that is part of a manual digit 2.
http://purl.obolibrary.org/obo/UBERON_0005646	manual digit 3 epithelium	http://purl.obolibrary.org/obo/UBERON_0005227	manual digit epithelium		An epithelium that is part of a manual digit 3.
http://purl.obolibrary.org/obo/UBERON_0005647	manual digit 4 epithelium	http://purl.obolibrary.org/obo/UBERON_0005227	manual digit epithelium		An epithelium that is part of a manual digit 4.
http://purl.obolibrary.org/obo/UBERON_0005648	manual digit 5 epithelium	http://purl.obolibrary.org/obo/UBERON_0005227	manual digit epithelium		An epithelium that is part of a manual digit 5.
http://purl.obolibrary.org/obo/UBERON_0005649	pedal digit 2 epithelium	http://purl.obolibrary.org/obo/UBERON_0005226	pedal digit epithelium		An epithelium that is part of a pedal digit 2.
http://purl.obolibrary.org/obo/UBERON_0005650	pedal digit 3 epithelium	http://purl.obolibrary.org/obo/UBERON_0005226	pedal digit epithelium		An epithelium that is part of a pedal digit 3.
http://purl.obolibrary.org/obo/UBERON_0005651	pedal digit 4 epithelium	http://purl.obolibrary.org/obo/UBERON_0005226	pedal digit epithelium		An epithelium that is part of a pedal digit 4.
http://purl.obolibrary.org/obo/UBERON_0005652	pedal digit 5 epithelium	http://purl.obolibrary.org/obo/UBERON_0005226	pedal digit epithelium		An epithelium that is part of a pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0005653	upper jaw molar epithelium	http://purl.obolibrary.org/obo/UBERON_0015839	molar epithelium		A dental epithelium that is part of a upper jaw molar.
http://purl.obolibrary.org/obo/UBERON_0005654	lower jaw molar epithelium	http://purl.obolibrary.org/obo/UBERON_0015839	molar epithelium		A dental epithelium that is part of a lower jaw molar.
http://purl.obolibrary.org/obo/UBERON_0005656	lens vesicle epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a lens vesicle.
http://purl.obolibrary.org/obo/UBERON_0005658	secondary palatal shelf epithelium	http://purl.obolibrary.org/obo/UBERON_0003235	epithelium of upper jaw		An epithelium that is part of a secondary palatal shelf.
http://purl.obolibrary.org/obo/UBERON_0005660	2nd arch ectoderm	http://purl.obolibrary.org/obo/UBERON_0000924	ectoderm		An ectoderm that is part of a pharyngeal arch 2.
http://purl.obolibrary.org/obo/UBERON_0005661	3rd arch ectoderm	http://purl.obolibrary.org/obo/UBERON_0000924	ectoderm		An ectoderm that is part of a pharyngeal arch 3.
http://purl.obolibrary.org/obo/UBERON_0005662	4th arch ectoderm	http://purl.obolibrary.org/obo/UBERON_0000924	ectoderm		An ectoderm that is part of a pharyngeal arch 4.
http://purl.obolibrary.org/obo/UBERON_0005664	2nd arch endoderm	http://purl.obolibrary.org/obo/UBERON_0000925	endoderm		An endoderm that is part of a pharyngeal arch 2.
http://purl.obolibrary.org/obo/UBERON_0005665	3rd arch endoderm	http://purl.obolibrary.org/obo/UBERON_0000925	endoderm		An endoderm that is part of a pharyngeal arch 3.
http://purl.obolibrary.org/obo/UBERON_0005666	4th arch endoderm	http://purl.obolibrary.org/obo/UBERON_0000925	endoderm		An endoderm that is part of a pharyngeal arch 4.
http://purl.obolibrary.org/obo/UBERON_0005669	peritoneal cavity mesothelium	http://purl.obolibrary.org/obo/UBERON_0001136	mesothelium		A mesothelium that is part of a peritoneal cavity.
http://purl.obolibrary.org/obo/UBERON_0005672	right lung endothelium	http://purl.obolibrary.org/obo/UBERON_0003364	epithelium of right lung		An endothelium that is part of a right lung.
http://purl.obolibrary.org/obo/UBERON_0005673	left lung endothelium	http://purl.obolibrary.org/obo/UBERON_0003365	epithelium of left lung		An endothelium that is part of a left lung.
http://purl.obolibrary.org/obo/UBERON_0005687	orbitosphenoid cartilage element	http://purl.obolibrary.org/obo/UBERON_0015059	orbitosphenoid endochondral element		An orbitosphenoid endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0005688	lens vesicle cavity	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that is part of a lens vesicle.
http://purl.obolibrary.org/obo/UBERON_0005689	2nd arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009494	pharyngeal arch mesenchymal region		Mesenchyme that is part of a pharyngeal arch 2.
http://purl.obolibrary.org/obo/UBERON_0005690	3rd arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009494	pharyngeal arch mesenchymal region		Mesenchyme that is part of a pharyngeal arch 3.
http://purl.obolibrary.org/obo/UBERON_0005691	4th arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009494	pharyngeal arch mesenchymal region		Mesenchyme that is part of a pharyngeal arch 4.
http://purl.obolibrary.org/obo/UBERON_0005692	manual digit 2 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005257	manual digit mesenchyme		Mesenchyme that is part of a developing manual digit 2.
http://purl.obolibrary.org/obo/UBERON_0005693	manual digit 3 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005257	manual digit mesenchyme		Mesenchyme that is part of a developing manual digit 3.
http://purl.obolibrary.org/obo/UBERON_0005694	manual digit 4 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005257	manual digit mesenchyme		Mesenchyme that is part of a developing manual digit 4.
http://purl.obolibrary.org/obo/UBERON_0005695	manual digit 5 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005257	manual digit mesenchyme		Mesenchyme that is part of a developing manual digit 5.
http://purl.obolibrary.org/obo/UBERON_0005696	pedal digit 2 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005255	pedal digit mesenchyme		Mesenchyme that is part of a developing pedal digit 2.
http://purl.obolibrary.org/obo/UBERON_0005697	pedal digit 3 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005255	pedal digit mesenchyme		Mesenchyme that is part of a developing pedal digit 3.
http://purl.obolibrary.org/obo/UBERON_0005698	pedal digit 4 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005255	pedal digit mesenchyme		Mesenchyme that is part of a developing pedal digit 4.
http://purl.obolibrary.org/obo/UBERON_0005699	pedal digit 5 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005255	pedal digit mesenchyme		Mesenchyme that is part of a developing pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0005700	upper jaw molar odontogenic papilla	http://purl.obolibrary.org/obo/UBERON_0015844	molar dental papilla		An odontogenic papilla that is part of a upper jaw molar.
http://purl.obolibrary.org/obo/UBERON_0005701	lower jaw molar odontogenic papilla	http://purl.obolibrary.org/obo/UBERON_0015844	molar dental papilla		An odontogenic papilla that is part of a lower jaw molar.
http://purl.obolibrary.org/obo/UBERON_0005702	optic eminence mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Mesenchyme that is part of a optic eminence.
http://purl.obolibrary.org/obo/UBERON_0005704	secondary palatal shelf mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003323	mesenchyme of upper jaw		Mesenchyme that is part of a developing secondary palatal shelf.
http://purl.obolibrary.org/obo/UBERON_0005707	upper jaw incisor odontogenic papilla	http://purl.obolibrary.org/obo/UBERON_0010258	mesenchyme from rhombencephalic neural crest		An odontogenic papilla that is part of a upper jaw incisor.
http://purl.obolibrary.org/obo/UBERON_0005708	lower jaw incisor odontogenic papilla	http://purl.obolibrary.org/obo/UBERON_0010258	mesenchyme from rhombencephalic neural crest		An odontogenic papilla that is part of a lower jaw incisor.
http://purl.obolibrary.org/obo/UBERON_0005709	upper jaw incisor epithelium	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		A dental epithelium that is part of a upper jaw incisor.
http://purl.obolibrary.org/obo/UBERON_0005710	lower jaw incisor epithelium	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		A dental epithelium that is part of a lower jaw incisor.
http://purl.obolibrary.org/obo/UBERON_0005711	foregut duodenum mesentery	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		A mesentery of duodenum that is part of a foregut.
http://purl.obolibrary.org/obo/UBERON_0005712	midgut duodenum mesentery	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		A mesentery of duodenum that is part of a midgut.
http://purl.obolibrary.org/obo/UBERON_0005719	footplate apical ectodermal ridge	http://purl.obolibrary.org/obo/UBERON_0004356	apical ectodermal ridge		An apical ectodermal ridge that is part of a footplate.
http://purl.obolibrary.org/obo/UBERON_0005720	hindbrain venous system	http://purl.obolibrary.org/obo/UBERON_0004582	venous system		A venous system that is part of a hindbrain.
http://purl.obolibrary.org/obo/UBERON_0005721	pronephric mesoderm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A mesoderm that has the potential to develop into a pronephros.
http://purl.obolibrary.org/obo/UBERON_0005724	roof plate spinal cord region	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		A tissue that is part of a spinal cord and is part of a roof plate.
http://purl.obolibrary.org/obo/UBERON_0005725	olfactory system	http://purl.obolibrary.org/obo/UBERON_0005726	chemosensory system		A sensory system that is capable of olfaction (the sensory perception of smell).
http://purl.obolibrary.org/obo/UBERON_0005729	pectoral appendage field	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0005730	pelvic appendage field	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0005732	paired limb/fin field	http://purl.obolibrary.org/obo/UBERON_0007688	anlage		A ring of cells capable of forming a limb or paired fin[Gilbert,modified].
http://purl.obolibrary.org/obo/UBERON_0005733	limb field	http://purl.obolibrary.org/obo/UBERON_0005732	paired limb/fin field		A ring of cells capable of forming a limb.
http://purl.obolibrary.org/obo/UBERON_0005734	tunica adventitia of blood vessel	http://purl.obolibrary.org/obo/UBERON_0005742	adventitia		The outermost layer of a blood vessel, composed mainly of fibrous tissue.
http://purl.obolibrary.org/obo/UBERON_0005740	tunica intima of artery	http://purl.obolibrary.org/obo/UBERON_0004797	blood vessel layer		A tunica intima that is part of a artery.
http://purl.obolibrary.org/obo/UBERON_0005742	adventitia	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		An outermost connective tissue covering of an organ, vessel, or other structure[WP].
http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves.
http://purl.obolibrary.org/obo/UBERON_0005745	optic foramen	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An opening in the skull through which cranial nerve II passes.[MP].
http://purl.obolibrary.org/obo/UBERON_0005749	glomerular tuft	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The capillary loops of the kidney that normally function as a filtration unit[MP].
http://purl.obolibrary.org/obo/UBERON_0005753	caudal part of nephrogenic cord	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm.
http://purl.obolibrary.org/obo/UBERON_0005754	rostral part of nephrogenic cord	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros.
http://purl.obolibrary.org/obo/UBERON_0005764	acellular membrane	http://purl.obolibrary.org/obo/UBERON_0000476	acellular anatomical structure		An acellular anatomical structure that is the bounding layer of a anatomical structure.
http://purl.obolibrary.org/obo/UBERON_0005769	basement membrane of epithelium	http://purl.obolibrary.org/obo/UBERON_0005764	acellular membrane		An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina.
http://purl.obolibrary.org/obo/UBERON_0005777	glomerular basement membrane	http://purl.obolibrary.org/obo/UBERON_0005769	basement membrane of epithelium		The layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter.
http://purl.obolibrary.org/obo/UBERON_0005788	lamina rara interna	http://purl.obolibrary.org/obo/UBERON_0000476	acellular anatomical structure		Layer of the glomerular basement membrane adjacent to the glomerular capillary.
http://purl.obolibrary.org/obo/UBERON_0005792	nephric ridge	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Nephric tubules (nephrons) form embryonically along the nephric ridge. The ridge comprises three regions; anterior, middle and posterior. The functional kidney uses nephrons from only one or two regions of the ridge. A pronephric kidney uses only the nephrons from the anterior region of the ridge. A mesonephric kidney uses only the middle region, a metanephric kidney uses only the posterior region and an opisthonephric kidney uses the middle and posterior regions.
http://purl.obolibrary.org/obo/UBERON_0005800	section of aorta	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle.
http://purl.obolibrary.org/obo/UBERON_0005805	dorsal aorta	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
http://purl.obolibrary.org/obo/UBERON_0005806	portal system	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP].
http://purl.obolibrary.org/obo/UBERON_0005808	bone tissue of long bone	http://purl.obolibrary.org/obo/UBERON_0002481	bone tissue		A bone tissue that is part of a long bone.
http://purl.obolibrary.org/obo/UBERON_0005809	cortex of manus bone	http://purl.obolibrary.org/obo/UBERON_0003598	manus connective tissue		The outer or sperficial part of a bone of the manus.
http://purl.obolibrary.org/obo/UBERON_0005813	tubercle	http://purl.obolibrary.org/obo/UBERON_0004529	anatomical projection		A round nodule, small eminence, or warty outgrowth on an anatomical surface, such as bones, skin, or within the lungs (in the case of tuberculosis). They are also found on the leading edge of Humpback Whale's flippers, improving fluid flow over the flipper's surface[WP].
http://purl.obolibrary.org/obo/UBERON_0005814	arch of atlas	http://purl.obolibrary.org/obo/UBERON_0010358	arch of centrum of vertebra		A vertebral arch that is part of the first cervical vertebra.
http://purl.obolibrary.org/obo/UBERON_0005837	fasciculus of spinal cord	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		A fascicle that is part of a spinal cord.
http://purl.obolibrary.org/obo/UBERON_0005838	fasciculus of brain	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		A fascicle that is part of a brain.
http://purl.obolibrary.org/obo/UBERON_0005843	sacral spinal cord	http://purl.obolibrary.org/obo/UBERON_0005844	spinal cord segment		A spinal cord segment that adjacent_to a sacral region.
http://purl.obolibrary.org/obo/UBERON_0005845	caudal segment of spinal cord	http://purl.obolibrary.org/obo/UBERON_0005844	spinal cord segment		A spinal cord segment that adjacent_to a caudal region.
http://purl.obolibrary.org/obo/UBERON_0005852	thoracic spinal cord ventral column	http://purl.obolibrary.org/obo/UBERON_0016551	subdivision of spinal cord ventral column		A subdivision of spinal cord ventral column that is part of a thoracic spinal cord.
http://purl.obolibrary.org/obo/UBERON_0005853	sacral spinal cord ventral column	http://purl.obolibrary.org/obo/UBERON_0016551	subdivision of spinal cord ventral column		A subdivision of spinal cord ventral column that is part of a sacral spinal cord.
http://purl.obolibrary.org/obo/UBERON_0005854	cervical spinal cord ventral column	http://purl.obolibrary.org/obo/UBERON_0016551	subdivision of spinal cord ventral column		A subdivision of spinal cord ventral column that is part of a cervical spinal cord.
http://purl.obolibrary.org/obo/UBERON_0005855	lumbar spinal cord ventral column	http://purl.obolibrary.org/obo/UBERON_0016551	subdivision of spinal cord ventral column		A subdivision of spinal cord ventral column that is part of a lumbar spinal cord.
http://purl.obolibrary.org/obo/UBERON_0005856	developing mesenchymal condensation	http://purl.obolibrary.org/obo/UBERON_0011585	cell condensation		A delimited region of dense mesenchyme within looser mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0005863	cartilaginous condensation	http://purl.obolibrary.org/obo/UBERON_0005856	developing mesenchymal condensation		Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes.
http://purl.obolibrary.org/obo/UBERON_0005866	pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0005856	developing mesenchymal condensation		A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts.
http://purl.obolibrary.org/obo/UBERON_0005867	mandibular prominence	http://purl.obolibrary.org/obo/UBERON_0012314	embryonic facial prominence		The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip.
http://purl.obolibrary.org/obo/UBERON_0005868	maxillary prominence	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw.
http://purl.obolibrary.org/obo/UBERON_0005870	olfactory pit	http://purl.obolibrary.org/obo/UBERON_0016566	pit		An indentation of the olfactory placode which ends when the pits hollows out to form the nasopharynx[GO].
http://purl.obolibrary.org/obo/UBERON_0005873	2nd arch pharyngeal cleft	http://purl.obolibrary.org/obo/UBERON_0005879	pharyngeal cleft		A groove that is situated between the 2nd and 3rd pharyngeal arch.
http://purl.obolibrary.org/obo/UBERON_0005874	3rd arch pharyngeal cleft	http://purl.obolibrary.org/obo/UBERON_0005879	pharyngeal cleft		A groove that is situated between the 3rd and 4th pharyngeal arch.
http://purl.obolibrary.org/obo/UBERON_0005876	undifferentiated genital tubercle	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin.
http://purl.obolibrary.org/obo/UBERON_0005879	pharyngeal cleft	http://purl.obolibrary.org/obo/UBERON_0006846	surface groove		An external pocketing of pharyngeal ectoderm that contacts a region of endoderm (a pharyngeal pouch) and interdigitates in the anterior and posterior directions by the pharyngeal arches.
http://purl.obolibrary.org/obo/UBERON_0005881	autopodial extension	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis.
http://purl.obolibrary.org/obo/UBERON_0005884	hyoid arch skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		A subdivision of skeleton that supports pharyngeal arch 2.
http://purl.obolibrary.org/obo/UBERON_0005891	coelomic epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		The epithelial lining of the surface of the coelom.
http://purl.obolibrary.org/obo/UBERON_0005893	leg bone	http://purl.obolibrary.org/obo/UBERON_0003464	hindlimb bone		A bone that is part of the region of the hindlimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. Counter-examples: any pes phalanx.
http://purl.obolibrary.org/obo/UBERON_0005897	manus bone	http://purl.obolibrary.org/obo/UBERON_0011250	autopod bone		A bone that is part of the manus skeleton. Note that this includes the carpal bones.
http://purl.obolibrary.org/obo/UBERON_0005899	pes bone	http://purl.obolibrary.org/obo/UBERON_0011250	autopod bone		A bone that is part of the pes skeleton.
http://purl.obolibrary.org/obo/UBERON_0005902	occipital region	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles.
http://purl.obolibrary.org/obo/UBERON_0005903	duct of seminal vesicle	http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system		Each seminal vesicle consists of a single tube, coiled upon itself, and giving off several irregular cecal diverticula; the separate coils, as well as the diverticula, are connected together by fibrous tissue. When uncoiled, the tube is about the diameter of a quill, and varies in length from 10 to 15 cm.; it ends posteriorly in a cul-de-sac; its anterior extremity becomes constricted into a narrow straight duct called the excretory duct of seminal gland (or duct of the seminal vesicle), which joins with the corresponding ductus deferens to form the ejaculatory duct[WP].
http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Any of the ducts that are part of a male reproductive system.
http://purl.obolibrary.org/obo/UBERON_0005906	serous sac	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA].
http://purl.obolibrary.org/obo/UBERON_0005908	conjunctival sac	http://purl.obolibrary.org/obo/UBERON_0005906	serous sac		A serous sac which is the aggregate of the conjunctiva plus the conjunctival space.
http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium	http://purl.obolibrary.org/obo/UBERON_0004119	endoderm-derived structure		Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA].
http://purl.obolibrary.org/obo/UBERON_0005928	external naris	http://purl.obolibrary.org/obo/UBERON_0003102	surface structure		A naris that provides one of the small external openings of the head that give passage to air for breathing.
http://purl.obolibrary.org/obo/UBERON_0005944	axial skeleton plus cranial skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified].
http://purl.obolibrary.org/obo/UBERON_0005946	outflow tract of atrium	http://purl.obolibrary.org/obo/UBERON_0004145	outflow tract		An outflow tract that is part of a cardiac atrium.
http://purl.obolibrary.org/obo/UBERON_0005953	outflow part of right ventricle	http://purl.obolibrary.org/obo/UBERON_0005337	outflow tract of ventricle		Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk.
http://purl.obolibrary.org/obo/UBERON_0005956	outflow part of left ventricle	http://purl.obolibrary.org/obo/UBERON_0005337	outflow tract of ventricle		Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta.
http://purl.obolibrary.org/obo/UBERON_0005965	outflow part of right atrium	http://purl.obolibrary.org/obo/UBERON_0005946	outflow tract of atrium		Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA].
http://purl.obolibrary.org/obo/UBERON_0005966	outflow part of left atrium	http://purl.obolibrary.org/obo/UBERON_0005946	outflow tract of atrium		An outflow tract of atrium that is part of a left atrium.
http://purl.obolibrary.org/obo/UBERON_0005969	eye trabecular meshwork	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP].
http://purl.obolibrary.org/obo/UBERON_0005970	brain commissure	http://purl.obolibrary.org/obo/UBERON_0007702	tract of brain		Any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain.
http://purl.obolibrary.org/obo/UBERON_0005971	amniotic fold	http://purl.obolibrary.org/obo/UBERON_0000478	extraembryonic structure		A sheet of somatopleure that grows upward over the embryo and eventually meets in the midline enclosing the embryo, eventually giving rise to the amnion and chorion[Kardong].
http://purl.obolibrary.org/obo/UBERON_0005979	crista terminalis	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium.
http://purl.obolibrary.org/obo/UBERON_0005983	heart layer	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		The laminar structure of the heart.
http://purl.obolibrary.org/obo/UBERON_0005985	coronary vessel	http://purl.obolibrary.org/obo/UBERON_0000055	vessel		Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation.
http://purl.obolibrary.org/obo/UBERON_0005988	atrium myocardial trabecula	http://purl.obolibrary.org/obo/UBERON_0000440	trabecula		The supporting bundles of muscular fibers lining the walls of the atrial myocardium.
http://purl.obolibrary.org/obo/UBERON_0005989	atrioventricular septum	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve.
http://purl.obolibrary.org/obo/UBERON_0005990	aortic valve cusp	http://purl.obolibrary.org/obo/UBERON_0006009	cusp of cardiac valve		The three fibrous triangular components and associated flap of the aortic valve.
http://purl.obolibrary.org/obo/UBERON_0005991	aortic valve anulus	http://purl.obolibrary.org/obo/UBERON_0006008	fibrous ring of heart		The fibrous ring of the aortic valve that attaches the cusps of aortic valve to the wall of left ventricle, and which consists of portions of the fibrous scallops of the posterior, right anterior and left anterior cusps.
http://purl.obolibrary.org/obo/UBERON_0005992	pulmonary valve cusp	http://purl.obolibrary.org/obo/UBERON_0006009	cusp of cardiac valve		The three fibrous triangular components and associated flap of the pulmonary valve.
http://purl.obolibrary.org/obo/UBERON_0005993	pulmonary valve anulus	http://purl.obolibrary.org/obo/UBERON_0006008	fibrous ring of heart		The fibrous ring of the pulmonary valve that attaches the cusps of pulmonary valve to the wall of right ventricle, and which consists of portions of the fibrous scallops of the anterior, right posterior and left posterior cusps.
http://purl.obolibrary.org/obo/UBERON_0005994	chorda tendineae	http://purl.obolibrary.org/obo/UBERON_0005983	heart layer		The tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria.
http://purl.obolibrary.org/obo/UBERON_0005995	mitral valve anulus	http://purl.obolibrary.org/obo/UBERON_0006008	fibrous ring of heart		The fibrous ring of the mitral valve that attaches the cusps of mitral valve to the heart, and which consists of portions of the fibrous scallops of the anterior and posterior cusps.
http://purl.obolibrary.org/obo/UBERON_0005996	mitral valve cusp	http://purl.obolibrary.org/obo/UBERON_0006009	cusp of cardiac valve		The two fibrous components and associated flaps of the mitral valve.
http://purl.obolibrary.org/obo/UBERON_0005997	tricuspid valve anulus	http://purl.obolibrary.org/obo/UBERON_0006008	fibrous ring of heart		The fibrous ring of the tricuspid valve that attaches the cusps of tricuspid valve to the heart, and which consists of portions of the fibrous scallops of the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp).
http://purl.obolibrary.org/obo/UBERON_0005998	tricuspid valve cusp	http://purl.obolibrary.org/obo/UBERON_0006009	cusp of cardiac valve		The three fibrous triangular components and associated flaps of the tricuspid valve.
http://purl.obolibrary.org/obo/UBERON_0006002	vitelline artery	http://purl.obolibrary.org/obo/UBERON_0004365	vitelline blood vessel		The paired arteries that carry blood to the yolk sac from the dorsal aorta.
http://purl.obolibrary.org/obo/UBERON_0006003	integumentary adnexa	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers.
http://purl.obolibrary.org/obo/UBERON_0006008	fibrous ring of heart	http://purl.obolibrary.org/obo/UBERON_0006444	annulus fibrosus		A ring of ribrous tissue that surrounds the atrioventricular and arterial orifices.
http://purl.obolibrary.org/obo/UBERON_0006009	cusp of cardiac valve	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The part of the heart valves that serves to seal the heart valves when closed. There are three cusps for each valve except for the mitral valve, which has only two (hence its alternate name, 'bicuspid valve'). 'Nodules' are located at the tip of the valve, to form a tighter seal[WP].
http://purl.obolibrary.org/obo/UBERON_0006010	hyaloid canal	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A small transparent canal running through the vitreous body from the optical nerve disc to the lens. It is formed by an invagination of the hyaloid, a membrane which encloses the vitreous body[WP].
http://purl.obolibrary.org/obo/UBERON_0006048	digit 1	http://purl.obolibrary.org/obo/UBERON_0019221	digit 1 or 5		A digit that is part of a digit 1 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0006049	digit 2	http://purl.obolibrary.org/obo/UBERON_0019222	digit 2, 3 or 4		A digit that is part of a digit 2 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0006050	digit 3	http://purl.obolibrary.org/obo/UBERON_0019222	digit 2, 3 or 4		A digit that is part of a digit 3 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0006051	digit 4	http://purl.obolibrary.org/obo/UBERON_0019222	digit 2, 3 or 4		A digit that is part of a digit 4 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0006058	multi-limb segment region	http://purl.obolibrary.org/obo/UBERON_0010758	subdivision of organism along appendicular axis		A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions).
http://purl.obolibrary.org/obo/UBERON_0006061	process of vertebra	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		A process projection from a part of the vertebra such as centrum or arches. Examples: transverse process, diapophyses, parapophyses, and zygapophyses (both the cranial zygapophyses and the caudal zygapophyses).
http://purl.obolibrary.org/obo/UBERON_0006062	zygapophysis	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Paired processes at the cephalic and caudal ends of the neural arch. They function as interlocking structures between adjacent vertebrae, and limit dorsoventral flexion and lateral movement of the column in the trunk region[AAO]. The articular processes or zygapophyses of a vertebra, in human anatomy contain two superior and two inferior, spring from the junctions of the pedicles and laminae. These stick out of an end of a vertebra to lock with a zygapophysis on the next vertebra, to make the backbone more stable. The superior processes project upward from a lower vertebra, and their articular surfaces are directed more or less backward. The inferior processes project downward from a higher vertebra, and their articular surfaces are directed more or less forward and outward. The articular surfaces are coated with hyaline cartilage.
http://purl.obolibrary.org/obo/UBERON_0006063	cartilaginous neural arch	http://purl.obolibrary.org/obo/UBERON_0010358	arch of centrum of vertebra		One of the cartilaginous structures surrounding the embryonic spinal cord, formed by the dorsal growth of the dorsolateral arcualia; it is the primordium of the vertebral arch.
http://purl.obolibrary.org/obo/UBERON_0006067	musculature of hindlimb zeugopod	http://purl.obolibrary.org/obo/UBERON_0004466	musculature of leg		Any collection of muscles that is part of a hindlimb zeugopod.
http://purl.obolibrary.org/obo/UBERON_0006068	bone of tail	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		A bone that is part of a post-anal tail.
http://purl.obolibrary.org/obo/UBERON_0006071	caudal region	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this.
http://purl.obolibrary.org/obo/UBERON_0006072	cervical region of vertebral column	http://purl.obolibrary.org/obo/UBERON_0006077	subdivision of vertebral column		That portion of the spine comprising the cervical vertebrae. The neck area of the spine.
http://purl.obolibrary.org/obo/UBERON_0006073	thoracic region of vertebral column	http://purl.obolibrary.org/obo/UBERON_0006077	subdivision of vertebral column		That part of the spine comprising the thoracic vertebrae.
http://purl.obolibrary.org/obo/UBERON_0006074	lumbar region of vertebral column	http://purl.obolibrary.org/obo/UBERON_0006077	subdivision of vertebral column		Subdivision of vertebral column that corresponds to the lumbar subdivision of the body, containing the lumbar vertebrae.
http://purl.obolibrary.org/obo/UBERON_0006075	sacral region of vertebral column	http://purl.obolibrary.org/obo/UBERON_0006077	subdivision of vertebral column		Subdivision of vertebral column that corresponds to the sacral subdivision of the body, containing the sacral vertebrae or sacrum.
http://purl.obolibrary.org/obo/UBERON_0006076	caudal region of vertebral column	http://purl.obolibrary.org/obo/UBERON_0006077	subdivision of vertebral column		Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae.
http://purl.obolibrary.org/obo/UBERON_0006077	subdivision of vertebral column	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		A collection of all skeletal elements in some subdivision of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0006098	basal nuclear complex	http://purl.obolibrary.org/obo/UBERON_0019264	gray matter of forebrain		The deep nuclei of telencephalic origin found in the basal region of the forebrain.
http://purl.obolibrary.org/obo/UBERON_0006127	funiculus of spinal cord	http://purl.obolibrary.org/obo/UBERON_0006133	funiculus of neuraxis		A funiculus of neuraxis that is part of a spinal cord.
http://purl.obolibrary.org/obo/UBERON_0006133	funiculus of neuraxis	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		The cerebrospinal nerves consist of numerous nerve fibers collected together and enclosed in membranous sheaths. A small bundle of fibers, enclosed in a tubular sheath, is called a funiculus; if the nerve is of small size, it may consist only of a single funiculus; but if large, the funiculi are collected together into larger bundles or fasciculi, which are bound together in a common membranous investment. Examples include: Anterior funiculus of the spinal cord Lateral funiculus of the spinal cord Posterior funiculus of the spinal cord Funiculus solitarius of the medulla Funiculus separans.
http://purl.obolibrary.org/obo/UBERON_0006134	nerve fiber	http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure		A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system.
http://purl.obolibrary.org/obo/UBERON_0006135	myelinated nerve fiber	http://purl.obolibrary.org/obo/UBERON_0006134	nerve fiber		Axons of neurons encased in a lipoproteinaceous material called myelin. (MeSH).
http://purl.obolibrary.org/obo/UBERON_0006170	mesonephric capsule	http://purl.obolibrary.org/obo/UBERON_0002015	kidney capsule		The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue.
http://purl.obolibrary.org/obo/UBERON_0006183	mesonephric glomerular capillary	http://purl.obolibrary.org/obo/UBERON_0004212	glomerular capillary		Missing definition for term UBERON:0006183. Please replace it using linked reference.
http://purl.obolibrary.org/obo/UBERON_0006204	inguinal ligament	http://purl.obolibrary.org/obo/UBERON_0005172	abdomen element		A band running from the pubic tubercle to the anterior superior iliac spine. Its anatomy is very important for operating on hernia patients. It forms the base of the inguinal canal through which an indirect inguinal hernia may develop. The inguinal ligament runs from the anterior superior iliac spine of the ilium to the pubic tubercle of the pubic bone. It is formed by the external abdominal oblique aponeurosis and is continuous with the fascia lata of the thigh.
http://purl.obolibrary.org/obo/UBERON_0006206	iridocorneal angle	http://purl.obolibrary.org/obo/UBERON_0000015	non-material anatomical boundary		Acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye[MP].
http://purl.obolibrary.org/obo/UBERON_0006207	aortico-pulmonary spiral septum	http://purl.obolibrary.org/obo/UBERON_0004142	outflow tract septum		The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.
http://purl.obolibrary.org/obo/UBERON_0006208	auditory hillocks	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		A collection of protruberances derived from pharyngeal arches 1 and 2 that develop into the folds of the pinna and gradually shift upwards and backwards to their final position on the head.
http://purl.obolibrary.org/obo/UBERON_0006211	buccopharyngeal membrane	http://purl.obolibrary.org/obo/UBERON_0003037	septum		The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx.
http://purl.obolibrary.org/obo/UBERON_0006213	carpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element		A cartilaginous condensation that has the potential to develop into a carpal bone.
http://purl.obolibrary.org/obo/UBERON_0006214	carpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element		A pre-cartilage condensation that has the potential to develop into a carpal bone.
http://purl.obolibrary.org/obo/UBERON_0006215	rhombic lip	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system.
http://purl.obolibrary.org/obo/UBERON_0006217	cloacal membrane	http://purl.obolibrary.org/obo/UBERON_0000158	membranous layer		The membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings.
http://purl.obolibrary.org/obo/UBERON_0006222	future diencephalon	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The foremost region of the future forebrain that develops into the diencephalon.
http://purl.obolibrary.org/obo/UBERON_0006233	female genital tubercle	http://purl.obolibrary.org/obo/UBERON_0011757	differentiated genital tubercle		A differentiated genital tubercle that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0006234	femur pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015052	femur endochondral element		A femur endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006235	foregut-midgut junction	http://purl.obolibrary.org/obo/UBERON_1100000	digestive tract junction		An anatomical junctions that overlaps the foregut and midgut.
http://purl.obolibrary.org/obo/UBERON_0006238	future brain	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The embryonic precursor of the brain.
http://purl.obolibrary.org/obo/UBERON_0006240	future forebrain	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a forebrain.
http://purl.obolibrary.org/obo/UBERON_0006242	gallbladder primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops.
http://purl.obolibrary.org/obo/UBERON_0006245	humerus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015053	humerus endochondral element		A humerus endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0006246	humerus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015053	humerus endochondral element		A humerus endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006248	incus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015017	incus endochondral element		An incus endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006254	ischial cartilage element	http://purl.obolibrary.org/obo/UBERON_0015056	ischial endochondral element		An ischial endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0006255	ischial pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015056	ischial endochondral element		An ischial endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006261	male genital tubercle	http://purl.obolibrary.org/obo/UBERON_0011757	differentiated genital tubercle		A differentiated genital tubercle that is part of a male reproductive system.
http://purl.obolibrary.org/obo/UBERON_0006262	malleus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015018	malleus endochondral element		A malleus endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006264	mouth-foregut junction	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		An anatomical junctions that overlaps the mouth and foregut.
http://purl.obolibrary.org/obo/UBERON_0006266	nasolacrimal groove	http://purl.obolibrary.org/obo/UBERON_0019306	nose epithelium		Groove between maxillary prominence and lateral nasal process.
http://purl.obolibrary.org/obo/UBERON_0006267	notochordal plate	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
http://purl.obolibrary.org/obo/UBERON_0006268	notochordal process	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
http://purl.obolibrary.org/obo/UBERON_0006271	orbital fissure	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		Either of two openings transmitting nerves and blood vessels to or from the orbit.
http://purl.obolibrary.org/obo/UBERON_0006273	otic pit	http://purl.obolibrary.org/obo/UBERON_0016566	pit		The pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles.
http://purl.obolibrary.org/obo/UBERON_0006279	pleuroperitoneal canal	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity.
http://purl.obolibrary.org/obo/UBERON_0006283	future cardiac ventricle	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle.
http://purl.obolibrary.org/obo/UBERON_0006284	early prosencephalic vesicle	http://purl.obolibrary.org/obo/UBERON_0013150	future brain vesicle		Future brain vesicle that gives rise to telencephalic ventricle/lateral ventricles and 3rd ventricle.
http://purl.obolibrary.org/obo/UBERON_0006285	pubic pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015055	pubic endochondral element		A pubic endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006286	radius cartilage element	http://purl.obolibrary.org/obo/UBERON_0015001	radius endochondral element		A cartilaginous condensation that has the potential to develop into a radius bone.
http://purl.obolibrary.org/obo/UBERON_0006287	radius-ulna pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015002	radius-ulna endochondral element		A radius-ulna endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006288	rib cartilage element	http://purl.obolibrary.org/obo/UBERON_0015019	rib endochondral element		A rib endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0006289	rib pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015019	rib endochondral element		A rib endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006290	scapula cartilage element	http://purl.obolibrary.org/obo/UBERON_0015057	scapula endochondral element		A scapula endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0006291	scapula pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015057	scapula endochondral element		A scapula endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006293	spleen primordium	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP].
http://purl.obolibrary.org/obo/UBERON_0006294	stapes pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015016	stapes endochondral element		A stapes endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0006297	sublingual gland primordium	http://purl.obolibrary.org/obo/UBERON_0017651	salivary gland primordium		A primordium that has the potential to develop into a sublingual gland.
http://purl.obolibrary.org/obo/UBERON_0006298	submandibular gland primordium	http://purl.obolibrary.org/obo/UBERON_0017651	salivary gland primordium		A primordium that has the potential to develop into a submandibular gland.
http://purl.obolibrary.org/obo/UBERON_0006306	ulna cartilage element	http://purl.obolibrary.org/obo/UBERON_0015003	ulna endochondral element		A cartilaginous condensation that has the potential to develop into a ulna.
http://purl.obolibrary.org/obo/UBERON_0006311	chamber of eyeball	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		A segment of the eyeball that is filled with refractive media.
http://purl.obolibrary.org/obo/UBERON_0006312	ocular refractive media	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		Body substance in a liquid or semi-solid state in the eyeball which serves to refract light.
http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
http://purl.obolibrary.org/obo/UBERON_0006320	inferior oblique extraocular muscle	http://purl.obolibrary.org/obo/UBERON_0006532	oblique extraocular muscle		Thin, narrow muscle placed near the anterior margin of the floor of the orbit.
http://purl.obolibrary.org/obo/UBERON_0006321	superior oblique extraocular muscle	http://purl.obolibrary.org/obo/UBERON_0006532	oblique extraocular muscle		The superior oblique muscle, or obliquus oculi superior, is a fusiform muscle in the upper, medial side of the orbit whose primary action is downward, lateral rotation of the eye. One of the extraocular muscles, the superior oblique is the only muscle innervated by the trochlear nerve (the fourth cranial nerve).
http://purl.obolibrary.org/obo/UBERON_0006322	inferior rectus extraocular muscle	http://purl.obolibrary.org/obo/UBERON_0006533	rectus extraocular muscle		A muscle in the orbit that depresses, adducts, and helps extort (rotate laterally) the eye. The inferior rectus muscle is the only muscle that is capable of depressing the pupil when it is in a fully abducted position.
http://purl.obolibrary.org/obo/UBERON_0006331	brainstem nucleus	http://purl.obolibrary.org/obo/UBERON_0002308	nucleus of brain		A nucleus of brain that is part of a brainstem.
http://purl.obolibrary.org/obo/UBERON_0006338	lateral ventricle choroid plexus stroma	http://purl.obolibrary.org/obo/UBERON_0005206	choroid plexus stroma		A choroid plexus stroma that is part of a lateral ventricle.
http://purl.obolibrary.org/obo/UBERON_0006339	third ventricle choroid plexus stroma	http://purl.obolibrary.org/obo/UBERON_0005206	choroid plexus stroma		A choroid plexus stroma that is part of a third ventricle.
http://purl.obolibrary.org/obo/UBERON_0006340	fourth ventricle choroid plexus stroma	http://purl.obolibrary.org/obo/UBERON_0005206	choroid plexus stroma		A choroid plexus stroma that is part of a fourth ventricle.
http://purl.obolibrary.org/obo/UBERON_0006347	communicating artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that connects two larger arteries.
http://purl.obolibrary.org/obo/UBERON_0006349	epigastric artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An external iliac artery branch that supplies blood to the anterior abdominal wall.
http://purl.obolibrary.org/obo/UBERON_0006356	epigastric vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains the anterior abdominal wall.
http://purl.obolibrary.org/obo/UBERON_0006430	xiphoid cartilage	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		A costal cartilage that is part of a xiphoid process.
http://purl.obolibrary.org/obo/UBERON_0006431	xiphoid process bone	http://purl.obolibrary.org/obo/UBERON_0003837	thoracic segment connective tissue		A bone tissue that is part of a xiphoid process.
http://purl.obolibrary.org/obo/UBERON_0006435	os penis	http://purl.obolibrary.org/obo/UBERON_0007719	bone of reproductive organ		The unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species.
http://purl.obolibrary.org/obo/UBERON_0006440	os clitoris	http://purl.obolibrary.org/obo/UBERON_0007719	bone of reproductive organ		The ossified region of endochondral and membranous bone located in the clitoris of most mammals except humans; it is homologous to the penile bone (aka as baculum, penis bone or os penis) in male mammals.
http://purl.obolibrary.org/obo/UBERON_0006444	annulus fibrosus	http://purl.obolibrary.org/obo/UBERON_0001995	fibrocartilage		A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart).
http://purl.obolibrary.org/obo/UBERON_0006497	interosseous muscle of pes	http://purl.obolibrary.org/obo/UBERON_0014378	intrinsic muscle of pes		Any of the interosseous muscles of the pes (foot). Includes the plantar and dorsal interossei.
http://purl.obolibrary.org/obo/UBERON_0006508	interosseous muscle of autopod	http://purl.obolibrary.org/obo/UBERON_0003661	limb muscle		Any of the muscles of the autopod region that lie between metacarpal or metatarsal bones.
http://purl.obolibrary.org/obo/UBERON_0006514	pallidum	http://purl.obolibrary.org/obo/UBERON_0003528	brain gray matter		Part of what are called the basal ganglia of the brain which consist of the globus pallidus and the ventral pallidum.
http://purl.obolibrary.org/obo/UBERON_0006517	kidney calyx	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		Recesses of the kidney pelvis which divides into two wide, cup-shaped major renal calices, with each major calix subdivided into 7 to 14 minor calices. Urine empties into a minor calix from collecting tubules, then passes through the major calix, renal pelvis, and ureter to enter the urinary bladder. (From Moore, Clinically Oriented Anatomy, 3d ed, p211).
http://purl.obolibrary.org/obo/UBERON_0006518	right lung lobe	http://purl.obolibrary.org/obo/UBERON_0000101	lobe of lung		A lobe of lung that is part of a right lung.
http://purl.obolibrary.org/obo/UBERON_0006524	alveolar system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		System pertaining to a bronchus and alveoli.
http://purl.obolibrary.org/obo/UBERON_0006530	seminal fluid	http://purl.obolibrary.org/obo/UBERON_0006536	male reproductive gland secretion		A substance formed from the secretion of one or more glands of the male genital tract in which sperm cells are suspended.
http://purl.obolibrary.org/obo/UBERON_0006531	oculomotor muscle	http://purl.obolibrary.org/obo/UBERON_0001601	extra-ocular muscle		The muscles that move the eye. Included in this group are the medial rectus, lateral rectus, superior rectus, inferior rectus, inferior oblique, superior oblique, musculus orbitalis, and levator palpebrae superioris.
http://purl.obolibrary.org/obo/UBERON_0006535	skin secretion	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		A portion of organism substance that secreted_by a zone of skin.
http://purl.obolibrary.org/obo/UBERON_0006536	male reproductive gland secretion	http://purl.obolibrary.org/obo/UBERON_0022293	reproductive gland secretion		A portion of organism substance that is secreted by a male reproductive gland.
http://purl.obolibrary.org/obo/UBERON_0006537	female reproductive gland secretion	http://purl.obolibrary.org/obo/UBERON_0022293	reproductive gland secretion		A portion of organism substance that is secreted by a female reproductive gland.
http://purl.obolibrary.org/obo/UBERON_0006538	respiratory system fluid/secretion	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		A portion of organism substance that secreted_by a respiratory system.
http://purl.obolibrary.org/obo/UBERON_0006539	mammary gland fluid/secretion	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		A substance that is secreted by a mammary gland. The substance may differ depending on phase, with colostrum produced during pregancy/early lactation, and milk produced afterwards.
http://purl.obolibrary.org/obo/UBERON_0006544	kidney vasculature	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		A vasculature that is part of a kidney.
http://purl.obolibrary.org/obo/UBERON_0006553	renal duct	http://purl.obolibrary.org/obo/UBERON_0000058	duct		A tube in the kidney that collect and transport urine.
http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube	http://purl.obolibrary.org/obo/UBERON_0000025	tube		A tube that is part of a excretory system.
http://purl.obolibrary.org/obo/UBERON_0006561	non-lymphatic part of lymphoid system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		An organ system subdivision that is the part of the lymphoid system that excludes the lymphatic vessels..
http://purl.obolibrary.org/obo/UBERON_0006563	tunica media of pulmonary trunk	http://purl.obolibrary.org/obo/UBERON_0007239	tunica media of artery		Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA].
http://purl.obolibrary.org/obo/UBERON_0006565	female urethral meatus	http://purl.obolibrary.org/obo/UBERON_0012240	urethral meatus		A urethral meatus that is part of a female urethra[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0006566	left ventricle myocardium	http://purl.obolibrary.org/obo/UBERON_0001083	myocardium of ventricle		A myocardium that is part of a left ventricle of a heart.
http://purl.obolibrary.org/obo/UBERON_0006567	right ventricle myocardium	http://purl.obolibrary.org/obo/UBERON_0001083	myocardium of ventricle		A myocardium that is part of a right ventricle of a heart.
http://purl.obolibrary.org/obo/UBERON_0006568	hypothalamic nucleus	http://purl.obolibrary.org/obo/UBERON_0006569	diencephalic nucleus		A nucleus of brain that is part of a hypothalamus.
http://purl.obolibrary.org/obo/UBERON_0006569	diencephalic nucleus	http://purl.obolibrary.org/obo/UBERON_0002308	nucleus of brain		A nucleus of brain that is part of a diencephalon.
http://purl.obolibrary.org/obo/UBERON_0006574	pectinate line	http://purl.obolibrary.org/obo/UBERON_8410024	intestinal junction		The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:.
http://purl.obolibrary.org/obo/UBERON_0006585	vestibular organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		An organ that is part of a vestibular system.
http://purl.obolibrary.org/obo/UBERON_0006595	presumptive endoderm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Presumptive structure of the blastula that will develop into endoderm.
http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Portion of embryonic tissue determined by fate mapping to become a structure.
http://purl.obolibrary.org/obo/UBERON_0006601	presumptive ectoderm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Presumptive structure of the blastula that will develop into ectoderm.
http://purl.obolibrary.org/obo/UBERON_0006603	presumptive mesoderm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Presumptive structure of the blastula that will develop into mesoderm.
http://purl.obolibrary.org/obo/UBERON_0006606	mandibular symphysis	http://purl.obolibrary.org/obo/UBERON_0002216	symphysis		A cartilaginous joint that connects left and right mandibles/dentary bones. Mandibular symphysis is unpaired[TAO,modified].
http://purl.obolibrary.org/obo/UBERON_0006608	corpus cavernosum clitoridis	http://purl.obolibrary.org/obo/UBERON_0006609	corpus cavernosum		The corpus cavernosum clitoridis is one of a pair of sponge-like regions of erectile tissue which contain most of the blood in the clitoris during clitoral erection. This is homologous to the corpus cavernosum penis in the male; the body of the clitoris contains erectile tissue in a pair of corpora cavernosa (literally 'cave-like bodies'), with a recognisably similar structure.
http://purl.obolibrary.org/obo/UBERON_0006614	aponeurosis	http://purl.obolibrary.org/obo/UBERON_0000158	membranous layer		A sheet of extracellular matrix.
http://purl.obolibrary.org/obo/UBERON_0006615	venous sinus	http://purl.obolibrary.org/obo/UBERON_0003920	venous blood vessel		A large vein or channel for the circulation of venous blood.
http://purl.obolibrary.org/obo/UBERON_0006616	right external ear	http://purl.obolibrary.org/obo/UBERON_0001691	external ear		An external ear that is in the right side of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0006617	left external ear	http://purl.obolibrary.org/obo/UBERON_0001691	external ear		An external ear that is in the left side of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0006632	musculo-phrenic artery	http://purl.obolibrary.org/obo/UBERON_0002057	phrenic artery		An artery with its origin in the lateral terminal branch of the internal thoracic artery, with distribution to the diaphragm and the intercostal muscles, and with anastomoses to the branches of the pericardiacophrenic and inferior phrenic.
http://purl.obolibrary.org/obo/UBERON_0006633	coracoid process of scapula	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		A process of the scapula in most mammals representing the remnant of the coracoid bone of lower vertebrates thas has become fused with the scapula.
http://purl.obolibrary.org/obo/UBERON_0006635	anterior abdominal wall	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		The abdominal wall represents the boundaries of the abdominal cavity. The abdominal wall is split into the posterior (back), lateral (sides) and anterior (front) walls. There is a common set of layers covering and forming all the walls: the deepest being the extraperitoneal fat, the parietal peritoneum, and a layer of fascia which has different names over where it covers (eg transversalis, psoas fascia). Superficial to these, but not present in the posterior wall are the three layers of muscle, the transversus abdominis (transverse abdominal muscle), the internal (obliquus internus) and the external oblique (obliquus externus).
http://purl.obolibrary.org/obo/UBERON_0006642	muscle layer of oviduct	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		A muscle layer that is part of a fallopian tube.
http://purl.obolibrary.org/obo/UBERON_0006645	adventitia of epididymis	http://purl.obolibrary.org/obo/UBERON_0005742	adventitia		An adventitia that is part of a epididymis.
http://purl.obolibrary.org/obo/UBERON_0006646	muscle layer of epididymis	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		A muscle layer that is part of a epididymis.
http://purl.obolibrary.org/obo/UBERON_0006647	adventitia of ductus deferens	http://purl.obolibrary.org/obo/UBERON_0005742	adventitia		An adventitia that is part of a vas deferens.
http://purl.obolibrary.org/obo/UBERON_0006648	adventitia of seminal vesicle	http://purl.obolibrary.org/obo/UBERON_0005742	adventitia		An adventitia that is part of a seminal vesicle.
http://purl.obolibrary.org/obo/UBERON_0006653	glans clitoris	http://purl.obolibrary.org/obo/UBERON_0008324	erectile tissue		Erectile tissue at the end of the clitoris, which is continuous with the intermediate part of the vestibulovaginal bulbs[BTO]. The clitoral glans (glans clitoridis) is an external portion of the clitoris[WP].
http://purl.obolibrary.org/obo/UBERON_0006655	septum of scrotum	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		An incomplete wall of connective tissue and nonstriated muscle (dartos fascia) dividing the scrotum into two sacs, each containing a testis.
http://purl.obolibrary.org/obo/UBERON_0006657	glenoid fossa	http://purl.obolibrary.org/obo/UBERON_0004704	bone fossa		Anatomical cavity for the proximal articular surface of the proximal limb or fin element with the scapulocoracoid or equivalent structure.
http://purl.obolibrary.org/obo/UBERON_0006658	interphalangeal joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		A joint that connects one phalanx to another along a proximodistal axis.
http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat	http://purl.obolibrary.org/obo/UBERON_0018260	layer of muscle tissue		A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis.
http://purl.obolibrary.org/obo/UBERON_0006661	epicranial aponeurosis	http://purl.obolibrary.org/obo/UBERON_0006614	aponeurosis		The galea aponeurotica (epicranial aponeurosis, aponeurosis epicranialis) is a tough layer of dense fibrous tissue which covers the upper part of the cranium; behind, it is attached, in the interval between its union with the Occipitales, to the external occipital protuberance and highest nuchal lines of the occipital bone; in front, it forms a short and narrow prolongation between its union with the Frontales. On either side it gives origin to the Auriculares anterior and superior; in this situation it loses its aponeurotic character, and is continued over the temporal fascia to the zygomatic arch as a layer of laminated areolar tissue. It is closely connected to the integument by the firm, dense, fibro-fatty layer which forms the superficial fascia of the scalp: it is attached to the pericranium by loose cellular tissue, which allows the aponeurosis, carrying with it the integument to move through a considerable distance.
http://purl.obolibrary.org/obo/UBERON_0006664	greater palatine artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The greater palatine artery is a terminal branch of the maxillary artery. It branches off of the maxillary artery in the pterygopalatine fossa and descends through the greater palatine foramen along with the greater palatine nerve and supplies the hard palate. It also anastomosis through the incisive canal with the sphenopalatine artery to supply the nasal cavity.
http://purl.obolibrary.org/obo/UBERON_0006668	carotid canal	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		On the interior surface of the temporal bone, behind the rough surface of the apex, is the large circular aperture of the carotid canal, which ascends at first vertically, and then, making a bend, runs horizontally forward and medialward. It transmits into the cranium, the internal carotid artery, and the carotid plexus of nerves. Sympathetics to the head also pass through the carotid canal. They have several motor functions: raise the eyelid (superior tarsal muscle), dilate pupil, innervate sweat glands of face and scalp and constricts blood vessels in head[WP].
http://purl.obolibrary.org/obo/UBERON_0006671	orbital fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		A fat pad that is part of a orbital region.
http://purl.obolibrary.org/obo/UBERON_0006673	mandibular canal	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		A canal within the mandible that contains the inferior alveolar nerve, inferior alveolar artery, and inferior alveolar vein. It runs obliquely downward and forward in the ramus, and then horizontally forward in the body, where it is placed under the alveoli and communicates with them by small openings.
http://purl.obolibrary.org/obo/UBERON_0006674	inguinal ring	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		An entrance or exit of the inguinal canal.
http://purl.obolibrary.org/obo/UBERON_0006675	venous valve	http://purl.obolibrary.org/obo/UBERON_0003978	valve		A valve that is part of a vein.
http://purl.obolibrary.org/obo/UBERON_0006677	surface of epithelium	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		An anatomical boundary that adjacent_to a epithelium.
http://purl.obolibrary.org/obo/UBERON_0006682	hypoglossal canal	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		The hypoglossal canal is a bony canal in the occipital bone of the skull.
http://purl.obolibrary.org/obo/UBERON_0006683	posterior fontanelle	http://purl.obolibrary.org/obo/UBERON_0002221	fontanelle		A gap between bones in the skull at the junction of the sagittal suture and lambdoidal suture.
http://purl.obolibrary.org/obo/UBERON_0006686	spinal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that is part of a vertebral column.
http://purl.obolibrary.org/obo/UBERON_0006689	frenulum of tongue	http://purl.obolibrary.org/obo/UBERON_0036293	oral frenulum		A small fold of mucous membrane extending from the floor of the mouth to the midline of the underside of the tongue.
http://purl.obolibrary.org/obo/UBERON_0006692	vertebral canal	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes.
http://purl.obolibrary.org/obo/UBERON_0006694	cerebellum vasculature	http://purl.obolibrary.org/obo/UBERON_0036303	vasculature of central nervous system		A vasculature that is part of a cerebellum.
http://purl.obolibrary.org/obo/UBERON_0006715	radio-ulna	http://purl.obolibrary.org/obo/UBERON_0015002	radius-ulna endochondral element		Paired, long bones of endochondral origin formed by the fusion of the radius and ulna.
http://purl.obolibrary.org/obo/UBERON_0006716	mesopodium region	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus).
http://purl.obolibrary.org/obo/UBERON_0006717	autopodial skeleton	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		The collection of all skeletal elements in an autopodium region.
http://purl.obolibrary.org/obo/UBERON_0006718	medial pterygoid muscle	http://purl.obolibrary.org/obo/UBERON_0006720	pterygoid muscle		The medial pterygoid is a pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to the medial pterygoid and attaches to the cranial base and the medial side of the mandibular angle.
http://purl.obolibrary.org/obo/UBERON_0006719	lateral pterygoid muscle	http://purl.obolibrary.org/obo/UBERON_0006720	pterygoid muscle		Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by the lateral pterygoid nerve branches, and attaches to the condylar process of the mandible and temporomandibular joint (TMJ) capsule, and the cranial base.
http://purl.obolibrary.org/obo/UBERON_0006722	manubrium of malleus	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The handle of the malleus; the portion that extends downward, inward, and backward from the neck of the malleus; it is embedded throughout its length in the tympanic membrane.
http://purl.obolibrary.org/obo/UBERON_0006723	cochlear modiolus	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The central cone shaped core of spongy bone about which turns the spiral canal.
http://purl.obolibrary.org/obo/UBERON_0006726	outer canthus	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A corner of the outer (lateral) part of an eye.
http://purl.obolibrary.org/obo/UBERON_0006742	canthus	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		A canthus is a corner of the eye where the upper and lower eyelids meet. The bicanthal plane is the transversal plane linking both canthi and defines the upper boundary of the midface.
http://purl.obolibrary.org/obo/UBERON_0006756	median lingual swelling	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		During the third week of embryological development there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings which rise from the inner surface of the mandibular arch and meet in the middle line. The site of their meeting remains post-embryonically as the median sulcus of the tongue. The tuberculum impar is said to form the central part of the tongue immediately in front of the foramen cecum, but Hammar insists that it is purely a transitory structure and forms no part of the adult tongue[WP, Gray's].
http://purl.obolibrary.org/obo/UBERON_0006757	lateral lingual swelling	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		During the third week there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings (or distal tongue bud) which rise from the inner surface of the mandibular arch and meet in the middle line.
http://purl.obolibrary.org/obo/UBERON_0006761	corneo-scleral junction	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm.
http://purl.obolibrary.org/obo/UBERON_0006762	suspensory ligament of lens	http://purl.obolibrary.org/obo/UBERON_0008841	suspensory ligament		The zonule of Zinn (Zinn's membrane, ciliary zonule) is a ring of fibrous strands connecting the ciliary body with the crystalline lens of the eye. The zonule of Zinn is split into two layers: a thin layer, which lines the hyaloid fossa, and a thicker layer, which is a collection of zonular fibers. Together, the fibers are known as the suspensory ligament of the lens[WP]. Modified or toughened vitreous that suspend the lens at the equator to the non-pigmented epithelium of the ciliary zone. In zebrafish, dorsal zonules are thickened as compared to ventral zonules. In both dorsal and ventral regions, these fibers delimit the vitreous body aqueous humor boundary[ZFA].
http://purl.obolibrary.org/obo/UBERON_0006763	epithelium of conjunctiva	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		Layer of nonkeratinized squamous epithelium lining the conjunctiva, overlying scleral tissue.
http://purl.obolibrary.org/obo/UBERON_0006767	head of femur	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		The hemispheric articular surface at the upper extremity of the thigh bone[Stedman, 26th ed]. The femur head is the highest part of the thigh bone. It is supported by the neck of the femur. The head is globular and forms rather more than a hemisphere, is directed upward, medialward, and a little forward, the greater part of its convexity being above and in front. Its surface is smooth, coated with cartilage in the fresh state, except over an ovoid depression, the fovea capitis femoris, which is situated a little below and behind the center of the head, and gives attachment to the ligament of head of femur. If there is a fracture of the neck of the femur, the blood supply through the ligament becomes crucial. In orthopedic surgery, the head of the femur is important because it can undergo avascular necrosis and consequent osteochondritis dissecans. The head is removed in total hip replacement surgery [WP].
http://purl.obolibrary.org/obo/UBERON_0006799	glandular epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is composed primarily of secretory cells.
http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line	http://purl.obolibrary.org/obo/UBERON_0000015	non-material anatomical boundary		Non-material anatomical entity of one dimension, which forms a boundary of an anatomical surface or is a modulation of an anatomical surface.
http://purl.obolibrary.org/obo/UBERON_0006801	proximal head of humerus	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		Hemispherical structure on proximal epiphysis of humerus that articulates with glenoid cavity[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0006805	sternal end of clavicle	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		Medial end of the clavicle, which usually lies on the ventral side of the epicoracoid cartilage, just posterior to the epicoracoid bridge.
http://purl.obolibrary.org/obo/UBERON_0006812	mental foramen	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		The mental foramen is one of two holes ('foramina') located on the anterior surface of the mandible. It permits passage of the mental nerve and vessels. The mental foramen descends slightly in edentulous individuals.
http://purl.obolibrary.org/obo/UBERON_0006813	nasal skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Structural framework that provides support to the nasal sacs and ducts.
http://purl.obolibrary.org/obo/UBERON_0006815	areolar connective tissue	http://purl.obolibrary.org/obo/UBERON_0011825	loose connective tissue		Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.
http://purl.obolibrary.org/obo/UBERON_0006822	proximal epiphysis of ulna	http://purl.obolibrary.org/obo/UBERON_0004386	epiphysis of ulna		The head of ulna presents an articular surface, part of which, of an oval or semilunar form, is directed downward, and articulates with the upper surface of the triangular articular disk which separates it from the wrist-joint; the remaining portion, directed lateralward, is narrow, convex, and received into the ulnar notch of the radius.
http://purl.obolibrary.org/obo/UBERON_0006833	lumen of trachea	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that surrounded_by a trachea.
http://purl.obolibrary.org/obo/UBERON_0006834	uterus or analog	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		A subdivision of a the reproductive tract in a female organism that is the site of embryo development.
http://purl.obolibrary.org/obo/UBERON_0006838	ventral ramus of spinal nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		Branch of spinal nerve that innervates the hypaxial muscles.
http://purl.obolibrary.org/obo/UBERON_0006839	dorsal ramus of spinal nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		Branch of spinal nerve that innervates the epaxial muscles.
http://purl.obolibrary.org/obo/UBERON_0006841	central vein of liver	http://purl.obolibrary.org/obo/UBERON_0015796	liver blood vessel		Vein that is central to a lobule in the liver.
http://purl.obolibrary.org/obo/UBERON_0006844	cusp of tooth	http://purl.obolibrary.org/obo/UBERON_0000476	acellular anatomical structure		A raised area of the biting surface of a tooth.
http://purl.obolibrary.org/obo/UBERON_0006846	surface groove	http://purl.obolibrary.org/obo/UBERON_0000466	immaterial anatomical entity		A furrow or an incomplete tube.
http://purl.obolibrary.org/obo/UBERON_0006847	cerebellar commissure	http://purl.obolibrary.org/obo/UBERON_0001020	nervous system commissure		A nervous system commissure that connects a left hemisphere of cerebellum and connects a right hemisphere of cerebellum.
http://purl.obolibrary.org/obo/UBERON_0006849	scapula	http://purl.obolibrary.org/obo/UBERON_0015057	scapula endochondral element		Endochondral bone that is dorsoventrally compressed and provides attachment site for muscles of the pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0006855	muscular coat of ureter	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		A muscular coat that is part of a ureter.
http://purl.obolibrary.org/obo/UBERON_0006858	adrenal/interrenal gland	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO].
http://purl.obolibrary.org/obo/UBERON_0006861	diaphysis proper	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		Subdivision of long bone which forms the part of the bone between two metaphyses. Note that the diaphysis includes the metaphyses, but the diaphysis proper excludes these.
http://purl.obolibrary.org/obo/UBERON_0006862	diaphysis of femur	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		A diaphysis that is part of a femur[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0006863	proximal metaphysis of femur	http://purl.obolibrary.org/obo/UBERON_0006865	metaphysis of femur		A proximal metaphysis that is part of a femur.
http://purl.obolibrary.org/obo/UBERON_0006864	distal metaphysis of femur	http://purl.obolibrary.org/obo/UBERON_0006865	metaphysis of femur		A distal metaphysis that is part of a femur.
http://purl.obolibrary.org/obo/UBERON_0006865	metaphysis of femur	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is part of a femur.
http://purl.obolibrary.org/obo/UBERON_0006866	terminal part of digestive tract	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus.
http://purl.obolibrary.org/obo/UBERON_0006867	anal part of perineum	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The anal triangle is the posterior part of the perineum. It contains the anal canal. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0006868	seminal fluid secreting gland	http://purl.obolibrary.org/obo/UBERON_0005399	male reproductive gland		A gland that secretes a seminal fluid.
http://purl.obolibrary.org/obo/UBERON_0006871	embryonic footplate	http://purl.obolibrary.org/obo/UBERON_0010130	embryonic autopod plate		The distal elements of the developing limb of vertebrates that will give rise to the pes (foot).
http://purl.obolibrary.org/obo/UBERON_0006872	handplate apical ectodermal ridge	http://purl.obolibrary.org/obo/UBERON_0004356	apical ectodermal ridge		An apical ectodermal ridge that is part of a handplate.
http://purl.obolibrary.org/obo/UBERON_0006875	embryonic handplate	http://purl.obolibrary.org/obo/UBERON_0010130	embryonic autopod plate		The distal elements of the developing limb of vertebrates that will give rise to the manus (hand).
http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vasculature that is part of a organ.
http://purl.obolibrary.org/obo/UBERON_0006877	vasculature of liver	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		A vasculature that is part of a liver.
http://purl.obolibrary.org/obo/UBERON_0006904	head mesenchyme from mesoderm	http://purl.obolibrary.org/obo/UBERON_0005253	head mesenchyme		A head mesenchyme that develops_from a mesoderm.
http://purl.obolibrary.org/obo/UBERON_0006905	mandibular process mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005253	head mesenchyme		Mesenchyme that is part of a mandibular prominence.
http://purl.obolibrary.org/obo/UBERON_0006906	ala of nose	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The lateral surface parts of the external nose, inferiorly, surrounding the naris[EoM].
http://purl.obolibrary.org/obo/UBERON_0006909	lumen of digestive tract	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that surrounded_by a digestive tract.
http://purl.obolibrary.org/obo/UBERON_0006913	lip epithelium	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		An epithelium that is part of a lip.
http://purl.obolibrary.org/obo/UBERON_0006914	squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.
http://purl.obolibrary.org/obo/UBERON_0006915	stratified squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006914	squamous epithelium		Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA].
http://purl.obolibrary.org/obo/UBERON_0006916	non-keratinized epithelium of tongue	http://purl.obolibrary.org/obo/UBERON_0010304	non-keratinized stratified squamous epithelium		A non-keratinized stratified squamous epithelium that is part of a tongue.
http://purl.obolibrary.org/obo/UBERON_0006919	tongue squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006914	squamous epithelium		A squamous epithelium that is part of a tongue.
http://purl.obolibrary.org/obo/UBERON_0006920	esophagus squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006914	squamous epithelium		A squamous epithelium that is part of a esophagus.
http://purl.obolibrary.org/obo/UBERON_0006921	stomach squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0001276	epithelium of stomach		A squamous epithelium that is part of a stomach.
http://purl.obolibrary.org/obo/UBERON_0006922	cervix squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0010304	non-keratinized stratified squamous epithelium		The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane.
http://purl.obolibrary.org/obo/UBERON_0006923	vagina squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006915	stratified squamous epithelium		A squamous epithelium that is part of a vagina.
http://purl.obolibrary.org/obo/UBERON_0006924	stomach glandular epithelium	http://purl.obolibrary.org/obo/UBERON_0006929	glandular columnar epithelium		A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands.
http://purl.obolibrary.org/obo/UBERON_0006925	digestive system gland	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		Any gland that is part of the digestive system.
http://purl.obolibrary.org/obo/UBERON_0006929	glandular columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0006799	glandular epithelium		Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA].
http://purl.obolibrary.org/obo/UBERON_0006931	stomach glandular region mucosa	http://purl.obolibrary.org/obo/UBERON_0001199	mucosa of stomach		Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region.
http://purl.obolibrary.org/obo/UBERON_0006932	vestibular epithelium	http://purl.obolibrary.org/obo/UBERON_0006937	inner ear epithelium		An epithelium that is part of a vestibular labyrinth.
http://purl.obolibrary.org/obo/UBERON_0006934	sensory epithelium	http://purl.obolibrary.org/obo/UBERON_0000488	atypical epithelium		Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue.
http://purl.obolibrary.org/obo/UBERON_0006936	thymus subcapsular epithelium	http://purl.obolibrary.org/obo/UBERON_0003846	thymus epithelium		The epithelial cells lining the capsule and trabeculae of the thymus.
http://purl.obolibrary.org/obo/UBERON_0006937	inner ear epithelium	http://purl.obolibrary.org/obo/UBERON_0015807	ear epithelium		The epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals.
http://purl.obolibrary.org/obo/UBERON_0006938	pinna surface epithelium	http://purl.obolibrary.org/obo/UBERON_0015814	outer ear epithelium		An epithelium that is part of a pinna.
http://purl.obolibrary.org/obo/UBERON_0006946	efferent duct	http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system		The efferent ducts (or efferent ductules or ductuli efferentes) connect the rete testis with the initial section of the epididymis. The ductuli are unilaminar and composed of columnar ciliated and non-ciliated (absorptive) cells. The ciliated cells serve to stir the luminal fluids, possibly to help ensure homogeneous absorption of water from the fluid produced by the testis, which results in an increase in the concentration of luminal sperm. The epithelium is surrounded by a band of smooth muscle that helps to propel the sperm toward the epididymis.
http://purl.obolibrary.org/obo/UBERON_0006947	male genital duct	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra.
http://purl.obolibrary.org/obo/UBERON_0006948	efferent duct epithelium	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		An epithelium that is part of a efferent duct.
http://purl.obolibrary.org/obo/UBERON_0006953	ejaculatory duct epithelium	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		The ejaculatory duct epithelium is composed of cuboidal to columnar cells between or through which project the terminal parts of the ducts of the unicellular prostate glands.
http://purl.obolibrary.org/obo/UBERON_0006955	uterine epithelium	http://purl.obolibrary.org/obo/UBERON_0004804	oviduct epithelium		An epithelium that is part of a uterus.
http://purl.obolibrary.org/obo/UBERON_0006957	submandibular gland primordium epithelium	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An epithelium that is part of a submandibular gland primordium.
http://purl.obolibrary.org/obo/UBERON_0006960	ovary stroma	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis.
http://purl.obolibrary.org/obo/UBERON_0006964	pars distalis of adenohypophysis	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The distal part of adenohypophysis: the part that makes up the main body of the gland.
http://purl.obolibrary.org/obo/UBERON_0006965	vascular cord	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA].
http://purl.obolibrary.org/obo/UBERON_0006966	coronary capillary	http://purl.obolibrary.org/obo/UBERON_0003498	heart blood vessel		A capillary that is part of the coronary system.
http://purl.obolibrary.org/obo/UBERON_0006983	anatomical point	http://purl.obolibrary.org/obo/UBERON_0000466	immaterial anatomical entity		Non-material anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface.
http://purl.obolibrary.org/obo/UBERON_0006984	anatomical surface	http://purl.obolibrary.org/obo/UBERON_0010199	bona-fide anatomical boundary		A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n.
http://purl.obolibrary.org/obo/UBERON_0007005	cardiogenic splanchnic mesoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO].
http://purl.obolibrary.org/obo/UBERON_0007010	cleaving embryo	http://purl.obolibrary.org/obo/UBERON_0000922	embryo		Organism at the cleavage stage.
http://purl.obolibrary.org/obo/UBERON_0007021	sexually immature organism	http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism		A multicellular organism that is at the juvenile stage.
http://purl.obolibrary.org/obo/UBERON_0007023	adult organism	http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism		A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage.
http://purl.obolibrary.org/obo/UBERON_0007098	mandibular neural crest	http://purl.obolibrary.org/obo/UBERON_0003099	cranial neural crest		Cranial neural crest that migrates into the mandibular arch.
http://purl.obolibrary.org/obo/UBERON_0007099	hyoid neural crest	http://purl.obolibrary.org/obo/UBERON_0003099	cranial neural crest		Cranial neural crest that migrates into the hyoid arch.
http://purl.obolibrary.org/obo/UBERON_0007100	primary circulatory organ	http://purl.obolibrary.org/obo/UBERON_0015228	circulatory organ		A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
http://purl.obolibrary.org/obo/UBERON_0007115	deciduous tooth	http://purl.obolibrary.org/obo/UBERON_0001091	calcareous tooth		One of the first set of teeth in the growth development of humans and many other mammals[WP].
http://purl.obolibrary.org/obo/UBERON_0007116	primary dentition	http://purl.obolibrary.org/obo/UBERON_0003672	dentition		The set of teeth first in order or time of development that will be replaced by permanent dentition upon their loss.
http://purl.obolibrary.org/obo/UBERON_0007118	umbilicus	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		The pit in the center of the abdominal wall marking the point where the umbilical cord entered in the fetus.
http://purl.obolibrary.org/obo/UBERON_0007119	neck of femur	http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element		The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward.
http://purl.obolibrary.org/obo/UBERON_0007120	premolar tooth	http://purl.obolibrary.org/obo/UBERON_0013164	molariform tooth		The premolar teeth or bicuspids are transitional teeth located between the canine and molar teeth.
http://purl.obolibrary.org/obo/UBERON_0007122	pharyngeal pouch 1	http://purl.obolibrary.org/obo/UBERON_0004117	pharyngeal pouch		A pharyngeal pouch that is between pharyngeal arches 1 and 2.
http://purl.obolibrary.org/obo/UBERON_0007123	pharyngeal pouch 2	http://purl.obolibrary.org/obo/UBERON_0004117	pharyngeal pouch		A pharyngeal puch that is between the pharyngeal arches 2 and 3.
http://purl.obolibrary.org/obo/UBERON_0007124	pharyngeal pouch 3	http://purl.obolibrary.org/obo/UBERON_0004117	pharyngeal pouch		A pharyngeal pouch that between pharyngeal arches 3 and 4.
http://purl.obolibrary.org/obo/UBERON_0007128	glomeral mesenchyme	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm.
http://purl.obolibrary.org/obo/UBERON_0007134	trunk ganglion	http://purl.obolibrary.org/obo/UBERON_0000045	ganglion		Ganglion which is located in the trunk.
http://purl.obolibrary.org/obo/UBERON_0007135	neural keel	http://purl.obolibrary.org/obo/UBERON_0016879	future central nervous system		An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section.
http://purl.obolibrary.org/obo/UBERON_0007142	left internal carotid artery	http://purl.obolibrary.org/obo/UBERON_0001532	internal carotid artery		An internal carotid artery that branching_part_of a left common carotid artery plus branches.
http://purl.obolibrary.org/obo/UBERON_0007143	right internal carotid artery	http://purl.obolibrary.org/obo/UBERON_0001532	internal carotid artery		An internal carotid artery that branching_part_of a right common carotid artery plus branches.
http://purl.obolibrary.org/obo/UBERON_0007144	embryonic post-anal tail	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail.
http://purl.obolibrary.org/obo/UBERON_0007147	lumen of midgut	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that surrounded_by a midgut.
http://purl.obolibrary.org/obo/UBERON_0007148	lumen of hindgut	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that surrounded_by a hindgut.
http://purl.obolibrary.org/obo/UBERON_0007151	mitral valve leaflet	http://purl.obolibrary.org/obo/UBERON_0011741	cardiac valve leaflet		A valve leafleft that is part of a mitral valve.
http://purl.obolibrary.org/obo/UBERON_0007156	inferior thyroid vein	http://purl.obolibrary.org/obo/UBERON_0018246	thyroid vein		The inferior thyroid veins two, frequently three or four, in number, arise in the venous plexus on the thyroid gland, communicating with the middle and superior thyroid veins. They form a plexus in front of the trachea, behind the Sternothyreoidei. From this plexus, a left vein descends and joins the left innominate trunk, and a right vein passes obliquely downward and to the right across the innominate artery to open into the right innominate vein, just at its junction with the superior vena cava; sometimes the right and left veins open by a common trunk in the latter situation. These veins receive esophageal tracheal, and inferior laryngeal veins, and are provided with valves at their terminations in the innominate veins.
http://purl.obolibrary.org/obo/UBERON_0007158	lumen of anal canal	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that surrounded_by a anal canal.
http://purl.obolibrary.org/obo/UBERON_0007159	lumen of colon	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that surrounded_by a colon.
http://purl.obolibrary.org/obo/UBERON_0007160	inferior petrosal sinus	http://purl.obolibrary.org/obo/UBERON_0017635	paired venous dural sinus		The inferior petrosal sinus, within the human head, is an area beneath the brain, which allows blood veins to span the area, from the center of the head downward. It drains from the cavernous sinus (beneath the brain) to the sigmoid sinuses above the internal jugular vein.
http://purl.obolibrary.org/obo/UBERON_0007173	lateral border of scapula	http://purl.obolibrary.org/obo/UBERON_0007171	border of scapula		The lateral border (or axillary border, or margin) is the thickest of the three borders of the scapula. It begins above at the lower margin of the glenoid cavity, and inclines obliquely downward and backward to the inferior angle. Immediately below the glenoid cavity is a rough impression, the infraglenoid tuberosity, about 2.5 cm. in length, which gives origin to the long head of the Triceps brachii; in front of this is a longitudinal groove, which extends as far as the lower third of this border, and affords origin to part of the Subscapularis. The inferior third is thin and sharp, and serves for the attachment of a few fibers of the Teres major behind, and of the Subscapularis in front.
http://purl.obolibrary.org/obo/UBERON_0007174	medial border of scapula	http://purl.obolibrary.org/obo/UBERON_0007171	border of scapula		The medial border of the scapula (vertebral border, medial margin) is the longest of the three borders, and extends from the medial to the inferior angle. It is arched, intermediate in thickness between the superior and the axillary borders, and the portion of it above the spine forms an obtuse angle with the part below. This border presents an anterior and a posterior lip, and an intermediate narrow area. The anterior lip affords attachment to the Serratus anterior; the posterior lip, to the Supraspinatus above the spine, the Infraspinatus below; the area between the two lips, to the Levator scapulC& above the triangular surface at the commencement of the spine, to the Rhomboideus minor on the edge of that surface, and to the Rhomboideus major below it; this last is attached by means of a fibrous arch, connected above to the lower part of the triangular surface at the base of the spine, and below to the lower part of the border.
http://purl.obolibrary.org/obo/UBERON_0007175	inferior angle of scapula	http://purl.obolibrary.org/obo/UBERON_0007172	angle of scapula		An angle of the scapula formed by the union of the vertebral and axillary borders; its dorsal surface affords attachment to the Teres major and frequently to a few fibers of the Latissimus dorsi.[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0007177	lamina propria of mucosa of colon	http://purl.obolibrary.org/obo/UBERON_0011189	lamina propria of large intestine		A lamina propria that is part of a colonic mucosa.
http://purl.obolibrary.org/obo/UBERON_0007181	serosa of infundibulum of uterine tube	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A serous membrane that is part of a uterine tube infundibulum.
http://purl.obolibrary.org/obo/UBERON_0007182	muscle layer of infundibulum of uterine tube	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		A muscle layer that is part of a uterine tube infundibulum.
http://purl.obolibrary.org/obo/UBERON_0007188	mesothelium of serous pericardium	http://purl.obolibrary.org/obo/UBERON_0003388	mesothelium of pericardial cavity		A mesothelium that is part of a serous pericardium.
http://purl.obolibrary.org/obo/UBERON_0007195	stroma of bone marrow	http://purl.obolibrary.org/obo/UBERON_0003891	stroma		The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis.
http://purl.obolibrary.org/obo/UBERON_0007196	tracheobronchial tree	http://purl.obolibrary.org/obo/UBERON_0000062	organ		The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells.
http://purl.obolibrary.org/obo/UBERON_0007197	hermaphroditic organism	http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism		Multicellular organism that can produce both male and female gametes.
http://purl.obolibrary.org/obo/UBERON_0007198	hermaphrodite anatomical structure	http://purl.obolibrary.org/obo/UBERON_0014402	sex-specific anatomical structure		An anatomical structure present only in hermaphrodites.
http://purl.obolibrary.org/obo/UBERON_0007204	brachiocephalic vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		The vasculature consisting of brachiocephalic arteries and veins.
http://purl.obolibrary.org/obo/UBERON_0007213	mesenchyme derived from head neural crest	http://purl.obolibrary.org/obo/UBERON_0005253	head mesenchyme		Mesenchyme that develops_from a cranial neural crest.
http://purl.obolibrary.org/obo/UBERON_0007214	mesenchyme derived from trunk neural crest	http://purl.obolibrary.org/obo/UBERON_0005256	trunk mesenchyme		Mesenchyme that develops_from a trunk neural crest.
http://purl.obolibrary.org/obo/UBERON_0007220	late embryonic stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		An embryo stage that covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching.
http://purl.obolibrary.org/obo/UBERON_0007223	osseus cochlea	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		The osseous cochlea is the bony foundation that forms the small shell arrangement for the cochlear nerve.
http://purl.obolibrary.org/obo/UBERON_0007228	vestibular nucleus	http://purl.obolibrary.org/obo/UBERON_0007635	nucleus of medulla oblongata		A cranial nucleus for the vestibular nerve. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0007239	tunica media of artery	http://purl.obolibrary.org/obo/UBERON_0002522	tunica media		A tunica media that is part of a artery.
http://purl.obolibrary.org/obo/UBERON_0007240	tunica adventitia of artery	http://purl.obolibrary.org/obo/UBERON_0005734	tunica adventitia of blood vessel		A tunica adventitia that is part of a artery.
http://purl.obolibrary.org/obo/UBERON_0007241	tunica adventitia of vein	http://purl.obolibrary.org/obo/UBERON_0005734	tunica adventitia of blood vessel		A tunica adventitia that is part of a vein.
http://purl.obolibrary.org/obo/UBERON_0007242	tunica intima of vein	http://purl.obolibrary.org/obo/UBERON_0004797	blood vessel layer		A tunica intima that is part of a vein.
http://purl.obolibrary.org/obo/UBERON_0007243	tunica media of vein	http://purl.obolibrary.org/obo/UBERON_0002522	tunica media		A tunica media that is part of a vein.
http://purl.obolibrary.org/obo/UBERON_0007245	nuclear complex of neuraxis	http://purl.obolibrary.org/obo/UBERON_0002020	gray matter		Gray matter of the central nervous system which is a collection of clustered nuclei.
http://purl.obolibrary.org/obo/UBERON_0007247	nucleus of superior olivary complex	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei.
http://purl.obolibrary.org/obo/UBERON_0007250	lingual tonsil	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue.
http://purl.obolibrary.org/obo/UBERON_0007252	intervertebral disk of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		An intervertebral disk that is part of a cervical region of vertebral column. A cervical intervertebral disk connects at least one cervical vertebra, either to another cervical vertebra, or at one point on the vertebral colummn, to a thoracic vertebra.
http://purl.obolibrary.org/obo/UBERON_0007254	intervertebral disk of thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		An intervertebral disk that is part of a thoracic region of vertebral column. A thoracic intervertebral disk connects at least one thoracic vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0007255	intervertebral disk of lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		An intervertebral disk that is part of a lumbar region of vertebral column. A lumbar intervertebral disk connects at least one lumbar vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra.
http://purl.obolibrary.org/obo/UBERON_0007257	intervertebral disk of sacral vertebra	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		An intervertebral disk that is part of a sacral region of vertebral column. A sacral intervertebral disk connects at least one sacral vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra.
http://purl.obolibrary.org/obo/UBERON_0007260	intervertebral disk of third cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0007252	intervertebral disk of cervical vertebra		An intervertebral disk that connects a mammalian cervical vertebra 3 and connects a mammalian cervical vertebra 4.
http://purl.obolibrary.org/obo/UBERON_0007261	intervertebral disk of fourth cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0007252	intervertebral disk of cervical vertebra		An intervertebral disk that connects a mammalian cervical vertebra 4 and connects a mammalian cervical vertebra 5.
http://purl.obolibrary.org/obo/UBERON_0007262	intervertebral disk of fifth cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0007252	intervertebral disk of cervical vertebra		An intervertebral disk that connects a mammalian cervical vertebra 5 and connects a mammalian cervical vertebra 6.
http://purl.obolibrary.org/obo/UBERON_0007265	intervertebral disk of axis	http://purl.obolibrary.org/obo/UBERON_0007252	intervertebral disk of cervical vertebra		An intervertebral disk that connects a vertebral bone 2 and connects a mammalian cervical vertebra 3.
http://purl.obolibrary.org/obo/UBERON_0007266	intervertebral disk of atlas	http://purl.obolibrary.org/obo/UBERON_0007252	intervertebral disk of cervical vertebra		An intervertebral disk that connects a vertebral bone 1 and connects a vertebral bone 2.
http://purl.obolibrary.org/obo/UBERON_0007267	trachea pre-cartilage rings	http://purl.obolibrary.org/obo/UBERON_0009505	mesenchyme of trachea		A pre-cartilage condensation that is part of a trachea.
http://purl.obolibrary.org/obo/UBERON_0007269	pectoral appendage musculature	http://purl.obolibrary.org/obo/UBERON_0014793	musculature of pectoral complex		Any collection of muscles that is part of a pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0007270	pelvic appendage musculature	http://purl.obolibrary.org/obo/UBERON_0014792	musculature of pelvic complex		Any collection of muscles that is part of a pelvic appendage.
http://purl.obolibrary.org/obo/UBERON_0007271	appendage musculature	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Any collection of muscles that is part of an appendage.
http://purl.obolibrary.org/obo/UBERON_0007272	pectoral appendage skeleton	http://purl.obolibrary.org/obo/UBERON_0011582	paired limb/fin skeleton		Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle.
http://purl.obolibrary.org/obo/UBERON_0007273	pelvic appendage skeleton	http://purl.obolibrary.org/obo/UBERON_0011582	paired limb/fin skeleton		The collection of all skeletal elements in a pelvic appendage region.
http://purl.obolibrary.org/obo/UBERON_0007277	presumptive hindbrain	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.
http://purl.obolibrary.org/obo/UBERON_0007278	presumptive sinus venosus	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Portion of tissue that is part of the heart tube and will become the sinus venosus.
http://purl.obolibrary.org/obo/UBERON_0007279	presumptive atrioventricular canal	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a atrioventricular canal.
http://purl.obolibrary.org/obo/UBERON_0007280	presumptive endocardium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a endocardium.
http://purl.obolibrary.org/obo/UBERON_0007281	presumptive midbrain hindbrain boundary	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Embryonic structure that gives rise to the midbrain hindbrain boundary.
http://purl.obolibrary.org/obo/UBERON_0007282	presumptive segmental plate	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a presomitic mesoderm.
http://purl.obolibrary.org/obo/UBERON_0007284	presumptive neural plate	http://purl.obolibrary.org/obo/UBERON_0016879	future central nervous system		A presumptive structure that has the potential to develop into a neural plate.
http://purl.obolibrary.org/obo/UBERON_0007285	presumptive paraxial mesoderm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The part of the blastula that has the potential to develop into a paraxial mesoderm.
http://purl.obolibrary.org/obo/UBERON_0007288	presumptive forebrain midbrain boundary	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a forebrain-midbrain boundary.
http://purl.obolibrary.org/obo/UBERON_0007289	presumptive rhombomere 1	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a rhombomere 1.
http://purl.obolibrary.org/obo/UBERON_0007297	presumptive pronephric mesoderm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a pronephric mesoderm.
http://purl.obolibrary.org/obo/UBERON_0007299	choroid plexus of tectal ventricle	http://purl.obolibrary.org/obo/UBERON_0001886	choroid plexus		A choroid plexus that is part of a cerebral aqueduct.
http://purl.obolibrary.org/obo/UBERON_0007300	pectoral appendage blood vessel	http://purl.obolibrary.org/obo/UBERON_0007301	appendage blood vessel		A blood vessel that is part of a pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0007301	appendage blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that is part of a limb/fin.
http://purl.obolibrary.org/obo/UBERON_0007302	pectoral appendage vasculature	http://purl.obolibrary.org/obo/UBERON_0007304	appendage vasculature		A vasculature that is part of a pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0007303	pharyngeal vasculature	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		A vasculature that is part of a chordate pharynx.
http://purl.obolibrary.org/obo/UBERON_0007304	appendage vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vasculature that is part of a limb/fin.
http://purl.obolibrary.org/obo/UBERON_0007306	pronephric glomerular capillary	http://purl.obolibrary.org/obo/UBERON_0004212	glomerular capillary		A glomerular capillary that is part of a pronephros.
http://purl.obolibrary.org/obo/UBERON_0007307	pronephric glomerular basement membrane	http://purl.obolibrary.org/obo/UBERON_0005777	glomerular basement membrane		A glomerular basement membrane that is part of a pronephros.
http://purl.obolibrary.org/obo/UBERON_0007312	pudendal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		Either the internal or external pudendal arteries.
http://purl.obolibrary.org/obo/UBERON_0007315	internal pudendal artery	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The internal pudendal artery is an artery that branches off the internal iliac artery, providing blood to the external genitalia. The internal pudendal artery is the terminal branch of the anterior trunk of the internal iliac artery. It is smaller in the female than in the male.
http://purl.obolibrary.org/obo/UBERON_0007318	saphenous vein	http://purl.obolibrary.org/obo/UBERON_0035550	superficial vein		Either of two main superficial veins of the leg, one larger than the other, that begin at the foot.
http://purl.obolibrary.org/obo/UBERON_0007324	pancreatic lobule	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans.
http://purl.obolibrary.org/obo/UBERON_0007354	cartilage of pharyngotympanic tube	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		A triangular plate of elastic fibrocartilage that forms the cartilage component of the pharyngotympanic tube.
http://purl.obolibrary.org/obo/UBERON_0007355	bony part of pharyngotympanic tube	http://purl.obolibrary.org/obo/UBERON_0003566	head connective tissue		The bony part of pharyngotympanic tube is about 12 mm. in length. It begins in the carotid wall of the tympanic cavity, below the septum canalis musculotubarii, and, gradually narrowing, ends at the angle of junction of the squama and the petrous portion of the temporal bone, its extremity presenting a jagged margin which serves for the attachment of the cartilaginous portion.
http://purl.obolibrary.org/obo/UBERON_0007367	surface of tongue	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		An anatomical surface that is part of a tongue.
http://purl.obolibrary.org/obo/UBERON_0007371	superior surface of tongue	http://purl.obolibrary.org/obo/UBERON_0007367	surface of tongue		The upper (superior) side of the tongue.
http://purl.obolibrary.org/obo/UBERON_0007373	inferior surface of tongue	http://purl.obolibrary.org/obo/UBERON_0007367	surface of tongue		The lower (inferior) side of the tongue.
http://purl.obolibrary.org/obo/UBERON_0007374	incus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015017	incus endochondral element		An incus endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0007375	roof of mouth	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones.
http://purl.obolibrary.org/obo/UBERON_0007376	outer epithelium	http://purl.obolibrary.org/obo/UBERON_0003102	surface structure		The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].
http://purl.obolibrary.org/obo/UBERON_0007383	enveloping layer of ectoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Outermost layer of cells surrounding the embryo.
http://purl.obolibrary.org/obo/UBERON_0007384	appendage lymph vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		A lymphatic vessel that is part of a limb/fin.
http://purl.obolibrary.org/obo/UBERON_0007385	pectoral appendage lymph vessel	http://purl.obolibrary.org/obo/UBERON_0007384	appendage lymph vessel		A lymphatic vessel that is part of a pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0007386	pelvic appendage lymph vessel	http://purl.obolibrary.org/obo/UBERON_0007384	appendage lymph vessel		A lymphatic vessel that is part of a pelvic appendage.
http://purl.obolibrary.org/obo/UBERON_0007389	paired limb/fin cartilage	http://purl.obolibrary.org/obo/UBERON_0002418	cartilage tissue		A cartilage tissue that is part of a paired limb or fin.
http://purl.obolibrary.org/obo/UBERON_0007390	pectoral appendage cartilage tissue	http://purl.obolibrary.org/obo/UBERON_0007389	paired limb/fin cartilage		A cartilage tissue that is part of a pectoral appendage.
http://purl.obolibrary.org/obo/UBERON_0007391	pelvic appendage cartilage tissue	http://purl.obolibrary.org/obo/UBERON_0007389	paired limb/fin cartilage		A cartilage tissue that is part of a pelvic appendage.
http://purl.obolibrary.org/obo/UBERON_0007414	nucleus of midbrain tegmentum	http://purl.obolibrary.org/obo/UBERON_0000125	neural nucleus		A nucleus of brain that spans a midbrain tegmentum.
http://purl.obolibrary.org/obo/UBERON_0007416	cerebellar peduncle	http://purl.obolibrary.org/obo/UBERON_0014891	brainstem white matter		Any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem.
http://purl.obolibrary.org/obo/UBERON_0007418	neural decussation	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		Nerve fibers crossing the midline of the neuraxis relative to their point of origin, on a course to from one level of the nervous system to another. (CUMBO, Heimer, L. The Human Brain, 2nd ed., 1995, pg 6).
http://purl.obolibrary.org/obo/UBERON_0007425	decussation of diencephalon	http://purl.obolibrary.org/obo/UBERON_0007418	neural decussation		A neural decussation that is part of a diencephalon.
http://purl.obolibrary.org/obo/UBERON_0007473	lumen of epithelial sac	http://purl.obolibrary.org/obo/UBERON_0012467	enclosed anatomical space		The space within an epithelial sphere.
http://purl.obolibrary.org/obo/UBERON_0007475	matrix-based tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified.
http://purl.obolibrary.org/obo/UBERON_0007490	keratin-based acellular structure	http://purl.obolibrary.org/obo/UBERON_0000476	acellular anatomical structure		Acellular anatomical structure whose predominant constituent is keratin.
http://purl.obolibrary.org/obo/UBERON_0007499	epithelial sac	http://purl.obolibrary.org/obo/UBERON_0009856	sac		An epithelial tube that is open at one end only.
http://purl.obolibrary.org/obo/UBERON_0007500	epithelial tube open at both ends	http://purl.obolibrary.org/obo/UBERON_0003914	epithelial tube		An epithelial tube open at both ends that allows fluid flow.
http://purl.obolibrary.org/obo/UBERON_0007501	arborizing epithelial duct system	http://purl.obolibrary.org/obo/UBERON_0007499	epithelial sac		A collection of connected epithelial tubes with a single portal.
http://purl.obolibrary.org/obo/UBERON_0007503	epithelial vesicle	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		A closed epithelium with a lumen.
http://purl.obolibrary.org/obo/UBERON_0007521	smooth muscle sphincter	http://purl.obolibrary.org/obo/UBERON_0004590	sphincter muscle		A ring of smooth muscle cells whose contraction closes the opening of the ring.
http://purl.obolibrary.org/obo/UBERON_0007522	striated muscle sphincter	http://purl.obolibrary.org/obo/UBERON_0004590	sphincter muscle		A ring of striated muscle cells whose contraction closes the opening of the ring.
http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme with little extracellular matrix.
http://purl.obolibrary.org/obo/UBERON_0007529	loose mesenchyme tissue	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix.
http://purl.obolibrary.org/obo/UBERON_0007530	migrating mesenchyme population	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchymal cells that are migrating.
http://purl.obolibrary.org/obo/UBERON_0007567	regenerating anatomical structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that is undergoing regeneration.
http://purl.obolibrary.org/obo/UBERON_0007589	ciliated columnar oviduct epithelium	http://purl.obolibrary.org/obo/UBERON_0007592	ciliated columnar epithelium		A ciliated columnar epithelium that is part of a oviduct.
http://purl.obolibrary.org/obo/UBERON_0007590	cuboidal oviduct epithelium	http://purl.obolibrary.org/obo/UBERON_0010077	cuboidal epithelium		A cuboidal epithelium that is part of a oviduct.
http://purl.obolibrary.org/obo/UBERON_0007592	ciliated columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0007601	ciliated epithelium		Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA].
http://purl.obolibrary.org/obo/UBERON_0007601	ciliated epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelium bearing vibratile cilia on the free surface.
http://purl.obolibrary.org/obo/UBERON_0007602	stratified columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0012274	columnar epithelium		Stratified columnar epithelia is a rare type of epithelial tissue composed of column shaped cells arranged in multiple layers. Stratified columnar epithelia are found in the ocular conjunctiva of the eye, in parts of the pharynx and anus, the female's uterus, the male urethra and vas deferens. Also found in intralobular ducts in salivary glands.[WP].
http://purl.obolibrary.org/obo/UBERON_0007610	tibial artery	http://purl.obolibrary.org/obo/UBERON_0003516	hindlimb blood vessel		The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.
http://purl.obolibrary.org/obo/UBERON_0007617	synovial cavity of joint	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		An anatomical cavity that surrounded_by a synovial joint.
http://purl.obolibrary.org/obo/UBERON_0007618	synovial cavity of hip joint	http://purl.obolibrary.org/obo/UBERON_0007617	synovial cavity of joint		A synovial cavity of joint that is part of a hip joint.
http://purl.obolibrary.org/obo/UBERON_0007635	nucleus of medulla oblongata	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		A neural nucleus that is part of a medulla oblongata.
http://purl.obolibrary.org/obo/UBERON_0007641	trigeminal nuclear complex	http://purl.obolibrary.org/obo/UBERON_0007245	nuclear complex of neuraxis		The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].
http://purl.obolibrary.org/obo/UBERON_0007644	thoracic lymph node	http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ		A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes.
http://purl.obolibrary.org/obo/UBERON_0007645	future meninx	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx.
http://purl.obolibrary.org/obo/UBERON_0007646	endomeninx	http://purl.obolibrary.org/obo/UBERON_0007645	future meninx		The innermost layer of the mesenchymal capsule that surrounds the developing brain, primarily of neural crest origin. The endomeninx forms the leptomeninx.
http://purl.obolibrary.org/obo/UBERON_0007647	ectomeninx	http://purl.obolibrary.org/obo/UBERON_0007645	future meninx		The outermost layer of the mesenchymal capsule that surrounds the developing brain, of mixed paraxial mesoderm and neural crest origin. The ectomeninx forms the dura mater (both inner layer and outer chondrogenic layer).
http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that connects two structures.
http://purl.obolibrary.org/obo/UBERON_0007652	esophageal sphincter	http://purl.obolibrary.org/obo/UBERON_0004590	sphincter muscle		A sphincter that is part of an esophagus.
http://purl.obolibrary.org/obo/UBERON_0007684	uriniferous tubule	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		Functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule.
http://purl.obolibrary.org/obo/UBERON_0007687	kidney field	http://purl.obolibrary.org/obo/UBERON_0007688	anlage		Region of the embryo into the area in which the kidney rudiment will develop.
http://purl.obolibrary.org/obo/UBERON_0007688	anlage	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue.
http://purl.obolibrary.org/obo/UBERON_0007689	thyroid diverticulum	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		Endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor[MP]. The thyroid diverticulum is the embryological structure from which thyroid follicular cells derive. It grows from the floor of the pharnyx[WP].
http://purl.obolibrary.org/obo/UBERON_0007691	gustatory pore	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		The minute opening of a taste bud on the surface of the oral mucosa through which the gustatory hairs of the specialised neuroepithelial gustatory cells project.
http://purl.obolibrary.org/obo/UBERON_0007692	nucleus of thalamus	http://purl.obolibrary.org/obo/UBERON_0006569	diencephalic nucleus		A nucleus of brain that is part of a thalamus.
http://purl.obolibrary.org/obo/UBERON_0007699	tract of spinal cord	http://purl.obolibrary.org/obo/UBERON_0001018	axon tract		An axon tract that is part of a spinal cord.
http://purl.obolibrary.org/obo/UBERON_0007702	tract of brain	http://purl.obolibrary.org/obo/UBERON_0001018	axon tract		An axon tract that is part of a brain.
http://purl.obolibrary.org/obo/UBERON_0007719	bone of reproductive organ	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A bone that is part of a reproductive organ.
http://purl.obolibrary.org/obo/UBERON_0007721	interphalangeal joint of pes	http://purl.obolibrary.org/obo/UBERON_0006658	interphalangeal joint		The interphalangeal articulations of the foot (articulations of the phalanges) are ginglymoid joints, and each has a plantar and two collateral ligaments. The arrangement of these ligaments is similar to that in the metatarsophalangeal articulations: the Extensor tendons supply the places of dorsal ligaments.
http://purl.obolibrary.org/obo/UBERON_0007722	interphalangeal joint of manus	http://purl.obolibrary.org/obo/UBERON_0006658	interphalangeal joint		The interphalangeal articulations of hand are hinge-joints of the phalanges of the hand. There are two sets (except in the thumb): 'proximal interphalangeal joints' (PIP), those between the first (also called proximal) and second (intermediate) phalanges 'distal interphalangeal joints' (DIP), those between the second and third (distal) phalanges A similar group of articulations also function in the toes.
http://purl.obolibrary.org/obo/UBERON_0007723	interphalangeal joint of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0007722	interphalangeal joint of manus		An interphalangeal joint of manus that is part of a manual digit 1.
http://purl.obolibrary.org/obo/UBERON_0007724	interphalangeal joint of pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0007721	interphalangeal joint of pes		An interphalangeal joint of pes that is part of a pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0007725	interphalangeal joint of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0007721	interphalangeal joint of pes		An interphalangeal joint of pes that is part of a pedal digit 2.
http://purl.obolibrary.org/obo/UBERON_0007726	interphalangeal joint of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0007721	interphalangeal joint of pes		An interphalangeal joint of pes that is part of a pedal digit 3.
http://purl.obolibrary.org/obo/UBERON_0007727	interphalangeal joint of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0007721	interphalangeal joint of pes		An interphalangeal joint of pes that is part of a pedal digit 4.
http://purl.obolibrary.org/obo/UBERON_0007728	interphalangeal joint of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0007721	interphalangeal joint of pes		An interphalangeal joint of pes that is part of a pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0007729	interphalangeal joint of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0007722	interphalangeal joint of manus		An interphalangeal joint of manus that is part of a manual digit 2.
http://purl.obolibrary.org/obo/UBERON_0007730	interphalangeal joint of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0007722	interphalangeal joint of manus		An interphalangeal joint of manus that is part of a manual digit 3.
http://purl.obolibrary.org/obo/UBERON_0007731	interphalangeal joint of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0007722	interphalangeal joint of manus		An interphalangeal joint of manus that is part of a manual digit 4.
http://purl.obolibrary.org/obo/UBERON_0007732	interphalangeal joint of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0007722	interphalangeal joint of manus		An interphalangeal joint of manus that is part of a manual digit 5.
http://purl.obolibrary.org/obo/UBERON_0007735	metacarpophalangeal joint of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0003695	metacarpophalangeal joint		A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 1.
http://purl.obolibrary.org/obo/UBERON_0007738	metacarpophalangeal joint of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0003695	metacarpophalangeal joint		A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 2.
http://purl.obolibrary.org/obo/UBERON_0007741	metacarpophalangeal joint of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0003695	metacarpophalangeal joint		A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 3.
http://purl.obolibrary.org/obo/UBERON_0007744	metacarpophalangeal joint of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0003695	metacarpophalangeal joint		A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 4.
http://purl.obolibrary.org/obo/UBERON_0007747	metacarpophalangeal joint of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0003695	metacarpophalangeal joint		A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 5.
http://purl.obolibrary.org/obo/UBERON_0007750	metatarsophalangeal joint of pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0003696	metatarsophalangeal joint		A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0007753	metatarsophalangeal joint of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0003696	metatarsophalangeal joint		A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 2.
http://purl.obolibrary.org/obo/UBERON_0007756	metatarsophalangeal joint of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0003696	metatarsophalangeal joint		A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 3.
http://purl.obolibrary.org/obo/UBERON_0007759	metatarsophalangeal joint of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0003696	metatarsophalangeal joint		A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 4.
http://purl.obolibrary.org/obo/UBERON_0007762	metatarsophalangeal joint of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0003696	metatarsophalangeal joint		A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0007771	epidermis gland	http://purl.obolibrary.org/obo/UBERON_0002419	skin gland		A gland that is part of a epidermis.
http://purl.obolibrary.org/obo/UBERON_0007772	scrotal sweat	http://purl.obolibrary.org/obo/UBERON_0006536	male reproductive gland secretion		Any portion of sweat that is produced by a sweat gland of the scrotum.
http://purl.obolibrary.org/obo/UBERON_0007773	scrotal sweat gland	http://purl.obolibrary.org/obo/UBERON_0005399	male reproductive gland		Any sweat gland that is part of a scrotum.
http://purl.obolibrary.org/obo/UBERON_0007774	secondary dentition	http://purl.obolibrary.org/obo/UBERON_0003672	dentition		The teeth of adulthood that either replace or are added to the complement of deciduous teeth. (Boucher's Clinical Dental Terminology, 4th ed).
http://purl.obolibrary.org/obo/UBERON_0007775	secondary tooth	http://purl.obolibrary.org/obo/UBERON_0001091	calcareous tooth		A tooth that forms after a primary tooth.
http://purl.obolibrary.org/obo/UBERON_0007778	umbilical artery endothelium	http://purl.obolibrary.org/obo/UBERON_0001917	endothelium of artery		An endothelium that is part of a umbilical artery.
http://purl.obolibrary.org/obo/UBERON_0007779	transudate	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.
http://purl.obolibrary.org/obo/UBERON_0007794	secretion of serous gland	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Any fluid produced by a serous gland.
http://purl.obolibrary.org/obo/UBERON_0007806	connecting stalk	http://purl.obolibrary.org/obo/UBERON_0000478	extraembryonic structure		A bridge of mesoderm connecting the caudal end of the young embryo with the trophoblastic tissues; the precursor of the umbilical cord.
http://purl.obolibrary.org/obo/UBERON_0007807	connecting stalk vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vasculature that is part of a connecting stalk.
http://purl.obolibrary.org/obo/UBERON_0007808	adipose tissue of abdominal region	http://purl.obolibrary.org/obo/UBERON_0003567	abdomen connective tissue		Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots.
http://purl.obolibrary.org/obo/UBERON_0007811	craniocervical region	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.
http://purl.obolibrary.org/obo/UBERON_0007812	post-anal tail	http://purl.obolibrary.org/obo/UBERON_0002415	tail		A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton.
http://purl.obolibrary.org/obo/UBERON_0007823	appendage girdle region	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).
http://purl.obolibrary.org/obo/UBERON_0007826	peritoneal mesentery	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		Mesentery that is located in the peritoneum.
http://purl.obolibrary.org/obo/UBERON_0007827	external nose	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		External part of the nose containing the external nares.
http://purl.obolibrary.org/obo/UBERON_0007828	girdle bone/zone	http://purl.obolibrary.org/obo/UBERON_0010740	bone of appendage girdle complex		A bone that is part of a appendage girdle region.
http://purl.obolibrary.org/obo/UBERON_0007829	pectoral girdle bone	http://purl.obolibrary.org/obo/UBERON_0010741	bone of pectoral complex		A bone that is part of a pectoral girdle region.
http://purl.obolibrary.org/obo/UBERON_0007830	pelvic girdle bone/zone	http://purl.obolibrary.org/obo/UBERON_0010742	bone of pelvic complex		A bone element or fused bone that is part of pelvic girdle.
http://purl.obolibrary.org/obo/UBERON_0007832	pelvic girdle skeleton	http://purl.obolibrary.org/obo/UBERON_0010719	girdle skeleton		Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature.
http://purl.obolibrary.org/obo/UBERON_0007842	membrane bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		Bone element that arises as a result of intramembranous ossification.
http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Skeletal element that is composed of cartilage tissue and may be permanent or transient.
http://purl.obolibrary.org/obo/UBERON_0007845	regular connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue.
http://purl.obolibrary.org/obo/UBERON_0007846	dense regular connective tissue	http://purl.obolibrary.org/obo/UBERON_0011823	dense connective tissue		Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).
http://purl.obolibrary.org/obo/UBERON_0007914	bone of craniocervical region	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		A bone that is part of a craniocervical region.
http://purl.obolibrary.org/obo/UBERON_0007997	sesamoid bone of manus	http://purl.obolibrary.org/obo/UBERON_0011141	appendicular ossicle		A sesamoid bone that is part of a manus.
http://purl.obolibrary.org/obo/UBERON_0008000	sesamoid bone of pes	http://purl.obolibrary.org/obo/UBERON_0011141	appendicular ossicle		A sesamoid bone that is part of a pes.
http://purl.obolibrary.org/obo/UBERON_0008001	irregular bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid.
http://purl.obolibrary.org/obo/UBERON_0008114	joint of girdle	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		A skeletal joint that is part of a appendage girdle region.
http://purl.obolibrary.org/obo/UBERON_0008115	surface of cartilage	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		An anatomical surface that is part of a cartilage element.
http://purl.obolibrary.org/obo/UBERON_0008188	tendon of biceps brachii	http://purl.obolibrary.org/obo/UBERON_0000043	tendon		A tendon that attaches_to a biceps brachii.
http://purl.obolibrary.org/obo/UBERON_0008192	tendon of triceps brachii	http://purl.obolibrary.org/obo/UBERON_0000043	tendon		A tendon that attaches_to a triceps brachii.
http://purl.obolibrary.org/obo/UBERON_0008193	pneumatized bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD].
http://purl.obolibrary.org/obo/UBERON_0008196	muscle of pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0010891	pectoral complex muscle		Any muscle organ that is part of a pectoral girdle region.
http://purl.obolibrary.org/obo/UBERON_0008198	nail plate	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		The nail plate is the hard and translucent portion of the nail, composed of keratin.
http://purl.obolibrary.org/obo/UBERON_0008199	chin	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		A subdivision of the face that is the anteriormost part of the lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0008200	forehead	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		The part of the face above the eyes[MESH]. In human anatomy, the forehead is the fore part of the head. It is, formally, an area of the head bounded by three features, two of the skull and one of the scalp. The top of the forehead is marked by the hairline, the edge of the area where hair on the scalp grows. The bottom of the forehead is marked by the supraorbital ridge, the bone feature of the skull above the eyes. The two sides of the forehead are marked by the temporal ridge, a bone feature that links the supraorbital ridge to the coronal suture line and beyond[WP].
http://purl.obolibrary.org/obo/UBERON_0008203	pelvic cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The part of the ventral body cavity that is within the pelvis.
http://purl.obolibrary.org/obo/UBERON_0008229	craniocervical region musculature	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Musculature system of the pharyngeal and head regions.
http://purl.obolibrary.org/obo/UBERON_0008231	dorsal thoracic segment of trunk	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax.
http://purl.obolibrary.org/obo/UBERON_0008242	lower back muscle	http://purl.obolibrary.org/obo/UBERON_0003833	abdominal segment muscle		A muscle of back that is part of a lower back.
http://purl.obolibrary.org/obo/UBERON_0008243	upper back muscle	http://purl.obolibrary.org/obo/UBERON_0003830	thoracic segment muscle		A muscle of back that is part of a dorsal thoracic segment of trunk.
http://purl.obolibrary.org/obo/UBERON_0008255	right clavicle	http://purl.obolibrary.org/obo/UBERON_0001105	clavicle bone		A clavicle that is in the right side of a entire appendicular skeleton.
http://purl.obolibrary.org/obo/UBERON_0008256	left clavicle	http://purl.obolibrary.org/obo/UBERON_0001105	clavicle bone		A clavicle that is in the left side of a entire appendicular skeleton.
http://purl.obolibrary.org/obo/UBERON_0008266	periodontal ligament	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO].
http://purl.obolibrary.org/obo/UBERON_0008281	tooth bud	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		A knoblike tooth primordium that develops into the mature tooth and consists of enamel organ, dental papilla, and dental sac enclosing them.
http://purl.obolibrary.org/obo/UBERON_0008307	heart endothelium	http://purl.obolibrary.org/obo/UBERON_0004852	cardiovascular system endothelium		An endothelium that is part of a heart [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0008310	nasopharyngeal gland	http://purl.obolibrary.org/obo/UBERON_0003295	pharyngeal gland		A gland that is part of a nasopharynx.
http://purl.obolibrary.org/obo/UBERON_0008320	common penile artery	http://purl.obolibrary.org/obo/UBERON_0036269	penis blood vessel		The artery that serves blood to the penis. It subdivides into three arteries, the bulbourethral artery, the dorsal artery of the penis and the cavernosal artery.
http://purl.obolibrary.org/obo/UBERON_0008321	deep artery of penis	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The deep artery of the penis (artery to the corpus cavernosum), one of the terminal branches of the internal pudendal, arises from that vessel while it is situated between the two fascia of the urogenital diaphragm (deep perineal pouch). It pierces the inferior fascia, and, entering the crus penis obliquely, runs forward in the center of the corpus cavernosum penis, to which its branches are distributed.
http://purl.obolibrary.org/obo/UBERON_0008322	deep artery of clitoris	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The deep artery of clitoris is a branch of the internal pudendal artery.
http://purl.obolibrary.org/obo/UBERON_0008324	erectile tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		With numerous vascular spaces that may become engorged with blood.
http://purl.obolibrary.org/obo/UBERON_0008331	clitoral smooth muscle	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A smooth muscle tissue that is part of a clitoris.
http://purl.obolibrary.org/obo/UBERON_0008338	plantar part of pes	http://purl.obolibrary.org/obo/UBERON_0008837	palmar/plantar part of autopod		The sole is the bottom of the foot.
http://purl.obolibrary.org/obo/UBERON_0008340	nasal bridge	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canth[WP].
http://purl.obolibrary.org/obo/UBERON_0008341	columella nasi	http://purl.obolibrary.org/obo/UBERON_0003102	surface structure		The tissue that links the nasal tip to the nasal base, and separates the nares. It is the inferior margin of the nasal septum[EoM].
http://purl.obolibrary.org/obo/UBERON_0008342	intestinal villus of duodenum	http://purl.obolibrary.org/obo/UBERON_0001213	intestinal villus		An intestinal villus in the duodenum.
http://purl.obolibrary.org/obo/UBERON_0008343	intestinal villus of jejunum	http://purl.obolibrary.org/obo/UBERON_0001213	intestinal villus		An intestinal villus in the jejunum.
http://purl.obolibrary.org/obo/UBERON_0008344	intestinal villus of ileum	http://purl.obolibrary.org/obo/UBERON_0001213	intestinal villus		An intestinal villus in the ileum.
http://purl.obolibrary.org/obo/UBERON_0008345	ileal epithelium	http://purl.obolibrary.org/obo/UBERON_0013636	epithelium of intestinal villus		An epithelium that is part of a ileum.
http://purl.obolibrary.org/obo/UBERON_0008346	duodenal epithelium	http://purl.obolibrary.org/obo/UBERON_0013636	epithelium of intestinal villus		An epithelium that is part of a duodenum.
http://purl.obolibrary.org/obo/UBERON_0008367	breast epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a breast.
http://purl.obolibrary.org/obo/UBERON_0008397	tracheobronchial epithelium	http://purl.obolibrary.org/obo/UBERON_0004815	lower respiratory tract epithelium		Epithelium pertaining to the trachea and bronchi.
http://purl.obolibrary.org/obo/UBERON_0008420	buccal epithelium	http://purl.obolibrary.org/obo/UBERON_0002424	oral epithelium		An epithelium that is part of a buccal mucosa.
http://purl.obolibrary.org/obo/UBERON_0008425	mammary ridge	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A ridge of epidermal cells that will form the mammary placodes.
http://purl.obolibrary.org/obo/UBERON_0008429	cervical vertebral foramen	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		A vertebral foramen that is part of a cervical vertebra.
http://purl.obolibrary.org/obo/UBERON_0008430	lumbar vertebral foramen	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		A vertebral foramen that is part of a lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0008431	sacral foramen	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		A vertebral foramen that is part of a sacral vertebra.
http://purl.obolibrary.org/obo/UBERON_0008432	thoracic vertebral foramen	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		A vertebral foramen that is part of a thoracic vertebra.
http://purl.obolibrary.org/obo/UBERON_0008433	lumbar vertebral arch	http://purl.obolibrary.org/obo/UBERON_0004247	bone of dorsum		A neural arch that is part of a lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0008434	cervical vertebral arch	http://purl.obolibrary.org/obo/UBERON_0004247	bone of dorsum		A neural arch that is part of a cervical vertebra.
http://purl.obolibrary.org/obo/UBERON_0008435	vertebral arch of sacral segment	http://purl.obolibrary.org/obo/UBERON_0005179	pelvic region element		A neural arch that is part of a sacral vertebra.
http://purl.obolibrary.org/obo/UBERON_0008436	thoracic vertebral arch	http://purl.obolibrary.org/obo/UBERON_0004247	bone of dorsum		A neural arch that is part of a thoracic vertebra.
http://purl.obolibrary.org/obo/UBERON_0008447	intertarsal joint	http://purl.obolibrary.org/obo/UBERON_0001487	pes joint		Intertarsal articulations are the joints of the tarsus. The specific intertarsal articulations are: Talocalcaneal articulation Talocalcaneonavicular articulation Calcaneocuboid articulation Cuneonavicular articulation Cuboideonavicular articulation Intercuneiform articulation Cuneocuboid articulation.
http://purl.obolibrary.org/obo/UBERON_0008456	prezygapophysis of lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0001079	prezygapophysis		A prezygapophysis that is part of a lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0008457	prezygapophysis of sacral vertebra	http://purl.obolibrary.org/obo/UBERON_0001079	prezygapophysis		A prezygapophysis that is part of a sacral vertebra.
http://purl.obolibrary.org/obo/UBERON_0008459	prezygapophysis of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0001079	prezygapophysis		A prezygapophysis that is part of a cervical vertebra.
http://purl.obolibrary.org/obo/UBERON_0008460	prezygapophysis of thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0001079	prezygapophysis		A prezygapophysis that is part of a thoracic vertebra.
http://purl.obolibrary.org/obo/UBERON_0008461	postzygapophysis of lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0001080	postzygapophysis		An postzygapophysis that is part of a lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0008462	postzygapophysis of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0001080	postzygapophysis		An postzygapophysis that is part of a cervical vertebra.
http://purl.obolibrary.org/obo/UBERON_0008463	postzygapophysis of thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0001080	postzygapophysis		An postzygapophysis that is part of a thoracic vertebra.
http://purl.obolibrary.org/obo/UBERON_0008522	nasal muscle	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		Any muscle organ that is part of an nose.
http://purl.obolibrary.org/obo/UBERON_0008523	infrahyoid muscle	http://purl.obolibrary.org/obo/UBERON_0005493	hyoid muscle		The infrahyoid muscles are a group of four pairs of muscles in the anterior part of the neck. (The term infrahyoid refers to the region below to the hyoid bone in the neck. ) Collectively, they are referred to as the strap muscles, because the muscles are long and flat much like a strap.
http://purl.obolibrary.org/obo/UBERON_0008529	piriformis muscle	http://purl.obolibrary.org/obo/UBERON_0002000	gluteal muscle		The piriformis is a muscle in the gluteal region that originates from the anterior (front) part of the sacrum, the part of the spine in the gluteal region, and from the superior margin of the greater sciatic notch (as well as the sacroiliac joint capsule and the sacrotuberous ligament). It exits the pelvis through the greater sciatic foramen to insert on the greater trochanter of the femur. Its tendon often joins with the tendons of the superior gemellus, inferior gemellus, and obturator internus muscles prior to insertion[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0008571	suprahyoid muscle	http://purl.obolibrary.org/obo/UBERON_0005493	hyoid muscle		A muscle in the region above the hyoid bone in the neck. The suprahyoid muscles include digastric, stylohyoid, geniohyoid, and mylohyoid.
http://purl.obolibrary.org/obo/UBERON_0008572	posterior crico-arytenoid	http://purl.obolibrary.org/obo/UBERON_0010932	crico-arytenoid muscle		The posterior cricoarytenoid muscles are extremely small, paired muscles that extend from the posterior cricoid cartilage to the arytenoid cartilages in the larynx. By rotating the arytenoid cartilages laterally, these muscles abduct the vocal cords and thereby open the rima glottidis. Their action opposes the lateral cricoarytenoid muscles. The posterior cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X). Paralysis of the posterior cricoarytenoid muscles may lead to asphyxiation as they are the only laryngeal muscles to open the true vocal folds, allowing inspiration and expiration.
http://purl.obolibrary.org/obo/UBERON_0008573	lateral crico-arytenoid	http://purl.obolibrary.org/obo/UBERON_0010932	crico-arytenoid muscle		The lateral cricoarytenoid (also anterior cricoarytenoid) muscles extend from the lateral cricoid cartilage to the ipsilateral arytenoid cartilage. By rotating the arytenoid cartilages medially, these muscles adduct the vocal cords and thereby close the rima glottidis, protecting the airway. (Their action is antagonistic to that of the posterior cricoarytenoid muscles. ) The lateral cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X).
http://purl.obolibrary.org/obo/UBERON_0008585	levator veli palatini	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The levator veli palatini is the elevator muscle of the velum palatinum in the human body. During swallowing, it contracts, elevating the soft palate to help prevent food from entering the nasopharynx. It is innervated via the pharyngeal plexus, primarily by the vagus nerve (CN X). The levator veli palatini (Levator palati) is a thick, rounded muscle situated lateral to the choanC&. It arises from the under surface of the apex of the petrous part of the temporal bone and from the medial lamina of the cartilage of the auditory tube. After passing above the upper concave margin of the Constrictor pharyngis superior it spreads out in the palatine velum, its fibers extending obliquely downward and medially to the middle line, where they blend with those of the opposite side.
http://purl.obolibrary.org/obo/UBERON_0008588	procerus	http://purl.obolibrary.org/obo/UBERON_0008522	nasal muscle		The Procerus is a small pyramidal slip of muscle deep to the superior orbital nerve, artery and vein.
http://purl.obolibrary.org/obo/UBERON_0008593	zygomaticus major muscle	http://purl.obolibrary.org/obo/UBERON_0010437	zygomaticus muscle		Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980.
http://purl.obolibrary.org/obo/UBERON_0008594	zygomaticus minor muscle	http://purl.obolibrary.org/obo/UBERON_0010437	zygomaticus muscle		Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. This muscle is ventral to the zygomaticus minor and dorsal to the platysma muscle. In many mammals this muscle also has an attachment to the cartilage of the external ear, in which case it is called the auriculolabialis inferior. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980.
http://purl.obolibrary.org/obo/UBERON_0008595	levator anguli oris	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		The levator anguli oris (caninus) is a facial muscle of the mouth arising from the canine fossa, immediately below the infraorbital foramen. Its fibers are inserted into the angle of the mouth, intermingling with those of the Zygomaticus, Triangularis, and Orbicularis oris.
http://purl.obolibrary.org/obo/UBERON_0008596	mentalis muscle	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip and inferior to the lower lip (in humans this region is called the chin or mental region), the orbicularis oris muscle, and the mandible in the symphyseal region. See Diogo et al., 2009; Burrows et al., 2011).
http://purl.obolibrary.org/obo/UBERON_0008597	depressor anguli oris muscle	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		The Depressor anguli oris (Triangularis) arises from the oblique line of the mandible, whence its fibers converge, to be inserted, by a narrow fasciculus, into the angle of the mouth.
http://purl.obolibrary.org/obo/UBERON_0008598	risorius muscle	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		Facial muscle that attaches to the fascia of the masseter muscle and the facia of the skin in the region of the corner (angle) of the mouth. Even in species in which this muscle is present, it is highly variable. A true risorius muscle may only be present in Hominins (humans and great apes). See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980.
http://purl.obolibrary.org/obo/UBERON_0008715	muscle tissue of prostate	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A muscle tissue that is part of a prostate gland.
http://purl.obolibrary.org/obo/UBERON_0008772	proximal epiphysis of tibia	http://purl.obolibrary.org/obo/UBERON_0004383	epiphysis of tibia		A proximal epiphysis that is part of a tibia.
http://purl.obolibrary.org/obo/UBERON_0008775	proximal epiphysis of fibula	http://purl.obolibrary.org/obo/UBERON_0004388	epiphysis of fibula		A proximal epiphysis that is part of a fibula.
http://purl.obolibrary.org/obo/UBERON_0008777	hypaxial musculature	http://purl.obolibrary.org/obo/UBERON_0004479	musculature of trunk		Musculature that is derived from the hypaxial myotome region, trunk muscles that lie ventral to the horizontal septum of the vertebrae. Hypaxial muscles include some vertebral muscles, the diaphragm, the abdominal muscles, and all limb muscles.
http://purl.obolibrary.org/obo/UBERON_0008778	epaxial musculature	http://purl.obolibrary.org/obo/UBERON_0004479	musculature of trunk		Musculature that is derived from the epaxial myotome region, ventral to the horizontal septum of the vertebrae. Epaxial muscles include other (dorsal) muscles associated with the vertebrae, ribs, and base of the skull.
http://purl.obolibrary.org/obo/UBERON_0008780	inner cell mass derived epiblast	http://purl.obolibrary.org/obo/UBERON_0002532	epiblast (generic)		An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers.
http://purl.obolibrary.org/obo/UBERON_0008783	dorsal venous arch	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The dorsal venous arch of the foot is a superficial vein that connects the small saphenous vein and the great saphenous vein. Anatomically, it is defined by where the dorsal veins of the first and fifth digit, respectively, meet the great saphenous vein and small saphenous vein.
http://purl.obolibrary.org/obo/UBERON_0008784	lower limb segment	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		A limb segment that is part of a hindlimb.
http://purl.obolibrary.org/obo/UBERON_0008785	upper limb segment	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		A limb segment that is part of a forelimb.
http://purl.obolibrary.org/obo/UBERON_0008789	cranial fossa	http://purl.obolibrary.org/obo/UBERON_0004704	bone fossa		Any of the three large depressions in the posterior, middle, and anterior aspects of the floor of the cranial cavity.
http://purl.obolibrary.org/obo/UBERON_0008803	skin of cheek	http://purl.obolibrary.org/obo/UBERON_1000021	skin of face		A zone of skin that is part of a cheek.
http://purl.obolibrary.org/obo/UBERON_0008805	gingival groove	http://purl.obolibrary.org/obo/UBERON_0000093	sulcus		The gingival sulcus is an area of potential space between a tooth and the surrounding gingival tissue and is lined by sulcular epithelium. The depth of the sulcus (Latin for groove) is bounded by two entities: apically by the gingival fibers of the connective tissue attachment and coronally by the free gingival margin.
http://purl.obolibrary.org/obo/UBERON_0008810	nasopalatine nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A branch of that maxillary nerve that innervates the mucous membrane of the hard palate.
http://purl.obolibrary.org/obo/UBERON_0008811	intromittent organ	http://purl.obolibrary.org/obo/UBERON_0003135	male reproductive organ		An external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP].
http://purl.obolibrary.org/obo/UBERON_0008814	pharyngeal arch system	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified].
http://purl.obolibrary.org/obo/UBERON_0008816	embryonic head	http://purl.obolibrary.org/obo/UBERON_0000033	head		A head that is part of a embryo.
http://purl.obolibrary.org/obo/UBERON_0008817	thymus primordium endoderm	http://purl.obolibrary.org/obo/UBERON_0000925	endoderm		An endoderm that is part of a thymus primordium.
http://purl.obolibrary.org/obo/UBERON_0008823	neural tube derived brain	http://purl.obolibrary.org/obo/UBERON_0000489	cavitated compound organ		A brain that develops_from a neural tube.
http://purl.obolibrary.org/obo/UBERON_0008824	duct of epididymis	http://purl.obolibrary.org/obo/UBERON_0005904	duct of male reproductive system		Any duct branching of of the main epididymis duct.
http://purl.obolibrary.org/obo/UBERON_0008826	pulmonary surfactant	http://purl.obolibrary.org/obo/UBERON_0006538	respiratory system fluid/secretion		A substance formed by type II alveolar cells composed of surface-active lipoprotein complex (phospholipoprotein).
http://purl.obolibrary.org/obo/UBERON_0008833	great auricular nerve	http://purl.obolibrary.org/obo/UBERON_0035648	nerve innervating pinna		A nerve arising from the second and third cervical nerves from the cervical plexus and innervating the skin over the parotid gland, the skin of part of the ear, the adjacent portion of the scalp, cheek, and angle of the jaw.
http://purl.obolibrary.org/obo/UBERON_0008835	hepatic diverticulum	http://purl.obolibrary.org/obo/UBERON_0009854	digestive tract diverticulum		An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts.
http://purl.obolibrary.org/obo/UBERON_0008841	suspensory ligament	http://purl.obolibrary.org/obo/UBERON_0008845	nonskeletal ligament		A ligament that supports a body part, especially an organ.
http://purl.obolibrary.org/obo/UBERON_0008842	suspensory ligament of testis	http://purl.obolibrary.org/obo/UBERON_0008841	suspensory ligament		The cranial atrophic portion of the urogenital ridge attached to the cranial pole of the intraabdominal embryonic testis.
http://purl.obolibrary.org/obo/UBERON_0008843	gubernaculum testis	http://purl.obolibrary.org/obo/UBERON_0004346	gubernaculum (male or female)		The fetal ligament attached to the inferior end of the epididymis and testis and, at its other end, to the bottom of the scrotum; it is present during, and is thought to guide, the descent of the testis into the scrotum and then atrophies.
http://purl.obolibrary.org/obo/UBERON_0008844	gubernaculum (female)	http://purl.obolibrary.org/obo/UBERON_0004346	gubernaculum (male or female)		A gubernaculum that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0008845	nonskeletal ligament	http://purl.obolibrary.org/obo/UBERON_0000211	ligament		A ligament that does not connect two skeletal elements.
http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament	http://purl.obolibrary.org/obo/UBERON_0000211	ligament		Dense regular connective tissue connecting two or more adjacent skeletal elements[VSAO,modified].
http://purl.obolibrary.org/obo/UBERON_0008851	ectoplacental cavity	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals.
http://purl.obolibrary.org/obo/UBERON_0008854	root of molar tooth	http://purl.obolibrary.org/obo/UBERON_0003677	tooth root		The part of a molar tooth that is implanted in the gum; mandibular and maxillary molars usually have two and three roots, respectively.
http://purl.obolibrary.org/obo/UBERON_0008856	stomach muscularis externa	http://purl.obolibrary.org/obo/UBERON_0034933	layer of smooth muscle tissue		The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines.
http://purl.obolibrary.org/obo/UBERON_0008858	pyloric canal	http://purl.obolibrary.org/obo/UBERON_0009870	zone of stomach		The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter.
http://purl.obolibrary.org/obo/UBERON_0008861	pyloric gastric gland	http://purl.obolibrary.org/obo/UBERON_0000414	mucous gland		The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP].
http://purl.obolibrary.org/obo/UBERON_0008867	trabecular network of bone	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		The network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force.
http://purl.obolibrary.org/obo/UBERON_0008870	pulmonary alveolar parenchyma	http://purl.obolibrary.org/obo/UBERON_0008946	lung parenchyma		The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages.
http://purl.obolibrary.org/obo/UBERON_0008874	pulmonary acinus	http://purl.obolibrary.org/obo/UBERON_0001062	anatomical entity		The largest lung subunit in which all airways participate in gas exchange, and it is composed of the parenchyma of the respiratory bronchioles, alveolar ducts, and alveoli.
http://purl.obolibrary.org/obo/UBERON_0008876	hypodermis skeletal muscle layer	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Any skeletal muscle organ in the hypodermis / superficial fascia.
http://purl.obolibrary.org/obo/UBERON_0008882	spinal cord commissure	http://purl.obolibrary.org/obo/UBERON_0007699	tract of spinal cord		The nerve fiber tracts that span the midline of the spinal cord.
http://purl.obolibrary.org/obo/UBERON_0008884	left putamen	http://purl.obolibrary.org/obo/UBERON_0001874	putamen		A putamen that is part of a left cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0008885	right putamen	http://purl.obolibrary.org/obo/UBERON_0001874	putamen		A putamen that is part of a right cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0008886	pulmonary vascular system	http://purl.obolibrary.org/obo/UBERON_0007798	vascular system		The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins.
http://purl.obolibrary.org/obo/UBERON_0008887	rectal venous plexus	http://purl.obolibrary.org/obo/UBERON_0001593	venous plexus		The hemorrhoidal plexus (or rectal venous plexus) surrounds the rectum, and communicates in front with the vesical venous plexus in the male, and the uterovaginal plexus in the female. A free communication between the portal and systemic venous systems is established through the hemorrhoidal plexus.
http://purl.obolibrary.org/obo/UBERON_0008895	splanchnocranium	http://purl.obolibrary.org/obo/UBERON_0011159	primary subdivision of cranial skeletal system		Subdivision of endoskeleton derived from pharyngeal arches.
http://purl.obolibrary.org/obo/UBERON_0008896	post-hyoid pharyngeal arch	http://purl.obolibrary.org/obo/UBERON_0002539	pharyngeal arch		A pharyngeal arch that is posterior to the hyoid arch. i.e. any pharyngeal arch with a number 3 or higher.
http://purl.obolibrary.org/obo/UBERON_0008907	dermal bone	http://purl.obolibrary.org/obo/UBERON_0007842	membrane bone		Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO].
http://purl.obolibrary.org/obo/UBERON_0008909	perichordal bone	http://purl.obolibrary.org/obo/UBERON_0012075	replacement bone		Bone element that is adjacent to the notochord.
http://purl.obolibrary.org/obo/UBERON_0008946	lung parenchyma	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		A parenchyma that is part of a lung.
http://purl.obolibrary.org/obo/UBERON_0008951	left lung lobe	http://purl.obolibrary.org/obo/UBERON_0000101	lobe of lung		A lobe of lung that is part of a left lung.
http://purl.obolibrary.org/obo/UBERON_0008962	forelimb bone	http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element		A bone that is part of a forelimb region. Examples: humerus, any of the phalanges. Counter-example: scapula (a bone of the pectoral girdle). Note that we consider the forelimb to end at the shoulder.
http://purl.obolibrary.org/obo/UBERON_0008969	dental follicle	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		A sac containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts, cementoblasts and fibroblasts. They develop into the alveolar bone, the cementum with Sharpey's fibers and the periodontal ligament fibers respectively.
http://purl.obolibrary.org/obo/UBERON_0008982	fascia	http://purl.obolibrary.org/obo/UBERON_0007846	dense regular connective tissue		A dense regular connective tissue that that connects muscles together[WP, modified].
http://purl.obolibrary.org/obo/UBERON_0008987	renal parenchyma	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		The functional tissue of the kidney, consisting of the nephrons.
http://purl.obolibrary.org/obo/UBERON_0008989	submucosal esophageal gland	http://purl.obolibrary.org/obo/UBERON_0011148	submucosal gland		One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed.
http://purl.obolibrary.org/obo/UBERON_0008995	nucleus of cerebellar nuclear complex	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.
http://purl.obolibrary.org/obo/UBERON_0008998	vasculature of brain	http://purl.obolibrary.org/obo/UBERON_0036303	vasculature of central nervous system		System pertaining to blood vessels in the brain.
http://purl.obolibrary.org/obo/UBERON_0009002	placental membrane	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The membrane separating the fetal from the maternal blood in the placenta.
http://purl.obolibrary.org/obo/UBERON_0009010	periurethral tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Any portion of tissue that surrounds a urethra.
http://purl.obolibrary.org/obo/UBERON_0009014	lower back skin	http://purl.obolibrary.org/obo/UBERON_0003836	abdominal segment skin		A zone of skin that is part of a lower back.
http://purl.obolibrary.org/obo/UBERON_0009015	upper back skin	http://purl.obolibrary.org/obo/UBERON_0001418	skin of thorax		A zone of skin that is part of a dorsal thoracic segment of trunk.
http://purl.obolibrary.org/obo/UBERON_0009027	vesical artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies blood to the urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0009029	pudendal vein	http://purl.obolibrary.org/obo/UBERON_0003520	pelvis blood vessel		Either the internal or external pudendal vein, running from the genital-vulvar area and abdomen and down the leg.
http://purl.obolibrary.org/obo/UBERON_0009030	left pulmonary vein	http://purl.obolibrary.org/obo/UBERON_0002016	pulmonary vein		Vein that drains left lung and returns blood to the heart.
http://purl.obolibrary.org/obo/UBERON_0009032	right pulmonary vein	http://purl.obolibrary.org/obo/UBERON_0002016	pulmonary vein		Vein that drains right lung and returns blood to the heart.
http://purl.obolibrary.org/obo/UBERON_0009039	lymph node germinal center	http://purl.obolibrary.org/obo/UBERON_0010754	germinal center		A germinal center that is located in a lymph node.
http://purl.obolibrary.org/obo/UBERON_0009042	prostatic venous plexus	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		The prostatic veins form a well-marked prostatic plexus which lies partly in the fascial sheath of the prostate and partly between the sheath and the prostatic capsule. It communicates with the pudendal and vesical plexuses.
http://purl.obolibrary.org/obo/UBERON_0009097	gravid organism	http://purl.obolibrary.org/obo/UBERON_0007023	adult organism		An organism containing a developing embryo, fetus, or unborn offspring within the body.
http://purl.obolibrary.org/obo/UBERON_0009098	gravid uterus	http://purl.obolibrary.org/obo/UBERON_0000995	uterus		The uterus in pregnancy.
http://purl.obolibrary.org/obo/UBERON_0009114	cervical thymus	http://purl.obolibrary.org/obo/UBERON_0002370	thymus		A mature thymus that is entirely part of the cervical region.
http://purl.obolibrary.org/obo/UBERON_0009115	thoracic thymus	http://purl.obolibrary.org/obo/UBERON_0005178	thoracic cavity element		A mature thymus that is entirely part of thoracic region.
http://purl.obolibrary.org/obo/UBERON_0009117	indifferent gonad	http://purl.obolibrary.org/obo/UBERON_0000991	gonad		A gonad prior to differentiating into a definitive testis or ovary.
http://purl.obolibrary.org/obo/UBERON_0009122	adenohypophyseal placode	http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode		The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary.
http://purl.obolibrary.org/obo/UBERON_0009124	geniculate placode	http://purl.obolibrary.org/obo/UBERON_0003078	epibranchial placode		Rostralmost epibranchial placode. Associated with 1st branchial cleft.
http://purl.obolibrary.org/obo/UBERON_0009125	petrosal placode	http://purl.obolibrary.org/obo/UBERON_0003078	epibranchial placode		Epibranchial placode between geniculate and nodose. Associated with 2nd branchial cleft.
http://purl.obolibrary.org/obo/UBERON_0009126	nodosal placode	http://purl.obolibrary.org/obo/UBERON_0003078	epibranchial placode		Caudalmost epibranchial placode. Associated with 3rd branchial cleft.
http://purl.obolibrary.org/obo/UBERON_0009127	epibranchial ganglion	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Cranial ganglion which develops from an epibranchial placode.
http://purl.obolibrary.org/obo/UBERON_0009129	right atrium endocardium	http://purl.obolibrary.org/obo/UBERON_0002166	endocardium of atrium		Endocardium that is part of the right atrium.
http://purl.obolibrary.org/obo/UBERON_0009132	peroneus	http://purl.obolibrary.org/obo/UBERON_0004256	hindlimb zeugopod muscle		One of a group of three muscles fibularis (peronæus) longus, brevis, and tertius originating on the fibula and inserting on the metatarsals.
http://purl.obolibrary.org/obo/UBERON_0009133	pleuroperitoneal membrane	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities.
http://purl.obolibrary.org/obo/UBERON_0009139	right posterior cardinal vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A posterior cardinal vein that is in_the_right_side_of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0009141	craniocervical region vein	http://purl.obolibrary.org/obo/UBERON_0013140	systemic vein		A vein that is part of a craniocervical region.
http://purl.obolibrary.org/obo/UBERON_0009142	entire embryonic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		Sum total of mesenchyme in the embryo.
http://purl.obolibrary.org/obo/UBERON_0009191	sphenoid bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015060	sphenoid endochondral element		A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0009193	sphenoid cartilage element	http://purl.obolibrary.org/obo/UBERON_0015060	sphenoid endochondral element		A sphenoid endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0009198	craniofacial suture	http://purl.obolibrary.org/obo/UBERON_0002209	fibrous joint		Any suture between cranial and/or facial bones.
http://purl.obolibrary.org/obo/UBERON_0009199	facial suture	http://purl.obolibrary.org/obo/UBERON_0009198	craniofacial suture		Any suture between facial bones.
http://purl.obolibrary.org/obo/UBERON_0009200	limb epidermis	http://purl.obolibrary.org/obo/UBERON_3000981	limb external integument structure		The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium.
http://purl.obolibrary.org/obo/UBERON_0009201	nephric duct	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		A nephric duct is a tube that drains a primitive kidney[GO].
http://purl.obolibrary.org/obo/UBERON_0009203	internasal suture	http://purl.obolibrary.org/obo/UBERON_0011160	nasal suture		A suture joining the nasal bones.
http://purl.obolibrary.org/obo/UBERON_0009204	medial nasal process mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009501	mesenchyme of fronto-nasal process		Mesenchyme that is part of a medial nasal prominence.
http://purl.obolibrary.org/obo/UBERON_0009205	lateral nasal process mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009501	mesenchyme of fronto-nasal process		Mesenchyme that is part of a lateral nasal prominence.
http://purl.obolibrary.org/obo/UBERON_0009206	lateral nasal process surface ectoderm	http://purl.obolibrary.org/obo/UBERON_0014702	frontonasal process epithelium		An ectoderm that is part of a lateral nasal prominence.
http://purl.obolibrary.org/obo/UBERON_0009210	pharyngeal membrane	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		A thin fold of ectoderm and endoderm that separates the pharyngeal pouches from the pharyngeal clefts in a developing embryo.
http://purl.obolibrary.org/obo/UBERON_0009213	pharyngeal membrane of 1st arch	http://purl.obolibrary.org/obo/UBERON_0009210	pharyngeal membrane		A pharyngeal membrane that separates the first pharyngeal cleft from the first pharyngeal pouch.
http://purl.obolibrary.org/obo/UBERON_0009291	cartilaginous vertebral centrum	http://purl.obolibrary.org/obo/UBERON_0016491	vertebral centrum element		Cartilaginous form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified].
http://purl.obolibrary.org/obo/UBERON_0009471	dorsum of tongue	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The superior surface of the tongue divided by the sulcus terminalis into an anterior two-thirds, the presulcal part (pars presulcalis). and a posterior one-third, the postsulcal part (pars postsulcalis).
http://purl.obolibrary.org/obo/UBERON_0009472	axilla	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		The axilla is the area directly under the joint where the forelimb connects to the shoulder.
http://purl.obolibrary.org/obo/UBERON_0009477	associated mesenchyme of otic placode	http://purl.obolibrary.org/obo/UBERON_0007213	mesenchyme derived from head neural crest		Mesenchyme that is part of a otic placode.
http://purl.obolibrary.org/obo/UBERON_0009479	ectoderm of buccopharyngeal membrane	http://purl.obolibrary.org/obo/UBERON_0000924	ectoderm		An ectoderm that is part of a buccopharyngeal membrane.
http://purl.obolibrary.org/obo/UBERON_0009480	endoderm of buccopharyngeal membrane	http://purl.obolibrary.org/obo/UBERON_0000925	endoderm		An endoderm that is part of a buccopharyngeal membrane.
http://purl.obolibrary.org/obo/UBERON_0009482	associated mesenchyme of foregut-midgut junction	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a foregut-midgut junction.
http://purl.obolibrary.org/obo/UBERON_0009483	mesentery of foregut-midgut junction	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		A mesentery that is part of a foregut-midgut junction.
http://purl.obolibrary.org/obo/UBERON_0009494	pharyngeal arch mesenchymal region	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		A portion of mesenchymal tissue associated with an individual pharyngeal arch.
http://purl.obolibrary.org/obo/UBERON_0009497	epithelium of foregut-midgut junction	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An epithelium that is part of a foregut-midgut junction.
http://purl.obolibrary.org/obo/UBERON_0009500	periotic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0007213	mesenchyme derived from head neural crest		Anatomical region that surrounds the otic vesicle.
http://purl.obolibrary.org/obo/UBERON_0009501	mesenchyme of fronto-nasal process	http://purl.obolibrary.org/obo/UBERON_0007213	mesenchyme derived from head neural crest		The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head.
http://purl.obolibrary.org/obo/UBERON_0009503	mesenchyme of hindgut	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a developing hindgut.
http://purl.obolibrary.org/obo/UBERON_0009505	mesenchyme of trachea	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		Mesenchyme that is part of a developing trachea.
http://purl.obolibrary.org/obo/UBERON_0009506	mesenchyme of middle ear	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		Mesenchyme that is part of a developing middle ear.
http://purl.obolibrary.org/obo/UBERON_0009521	anal membrane endodermal component	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An endoderm that is part of a anal region.
http://purl.obolibrary.org/obo/UBERON_0009522	lateral lingual swelling epithelium	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An epithelium that is part of a lateral lingual swelling.
http://purl.obolibrary.org/obo/UBERON_0009523	mesenchyme of handplate	http://purl.obolibrary.org/obo/UBERON_0010377	mesenchyme from somatopleure		Mesenchyme that is part of a handplate.
http://purl.obolibrary.org/obo/UBERON_0009526	maxillary process mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Mesenchyme that is part of a maxillary prominence.
http://purl.obolibrary.org/obo/UBERON_0009536	vascular element of left lung	http://purl.obolibrary.org/obo/UBERON_0005629	vascular plexus		A vascular plexus that is part of a left lung.
http://purl.obolibrary.org/obo/UBERON_0009537	vascular element of right lung	http://purl.obolibrary.org/obo/UBERON_0005629	vascular plexus		A vascular plexus that is part of a right lung.
http://purl.obolibrary.org/obo/UBERON_0009538	mesenchyme of sublingual gland primordium	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Mesenchyme that is part of a sublingual gland primordium.
http://purl.obolibrary.org/obo/UBERON_0009539	mesenchyme of submandibular gland primordium	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Mesenchyme that is part of a submandibular gland primordium.
http://purl.obolibrary.org/obo/UBERON_0009548	hepatic sinusoid of left lobe of liver	http://purl.obolibrary.org/obo/UBERON_0001281	hepatic sinusoid		A hepatic sinusoid that is part of a left lobe of liver.
http://purl.obolibrary.org/obo/UBERON_0009549	hepatic sinusoid of right lobe of liver	http://purl.obolibrary.org/obo/UBERON_0001281	hepatic sinusoid		A hepatic sinusoid that is part of a right lobe of liver.
http://purl.obolibrary.org/obo/UBERON_0009550	endoderm of foregut-midgut junction	http://purl.obolibrary.org/obo/UBERON_0000925	endoderm		An endoderm that is part of a foregut-midgut junction.
http://purl.obolibrary.org/obo/UBERON_0009551	distal segment of digit	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium).
http://purl.obolibrary.org/obo/UBERON_0009552	distal segment of manual digit	http://purl.obolibrary.org/obo/UBERON_0009551	distal segment of digit		A segment of the manual digit containing the distal phalanx.
http://purl.obolibrary.org/obo/UBERON_0009553	distal segment of pedal digit	http://purl.obolibrary.org/obo/UBERON_0009551	distal segment of digit		A segment of the pedal digit containing the distal phalanx. Note this class represents a digit segment and thus includes tissues in addition to bone.
http://purl.obolibrary.org/obo/UBERON_0009559	metacarpal/tarsal-phalangeal joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		A skeletal joint that connects a mesopodium bone and connects a proximal phalanx.
http://purl.obolibrary.org/obo/UBERON_0009564	distal limb integumentary appendage	http://purl.obolibrary.org/obo/UBERON_0013703	integumentary projection		A nail, hoof or claw.
http://purl.obolibrary.org/obo/UBERON_0009565	nail of manual digit	http://purl.obolibrary.org/obo/UBERON_0001705	nail		A nail that is part of a manual digit.
http://purl.obolibrary.org/obo/UBERON_0009566	intestinal submucosa	http://purl.obolibrary.org/obo/UBERON_0018257	submucosa of digestive tract		A submucosa that is part of a intestine.
http://purl.obolibrary.org/obo/UBERON_0009567	nail of pedal digit	http://purl.obolibrary.org/obo/UBERON_0001705	nail		A nail that is part of a pedal digit.
http://purl.obolibrary.org/obo/UBERON_0009568	trunk region of vertebral column	http://purl.obolibrary.org/obo/UBERON_0006077	subdivision of vertebral column		Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions.
http://purl.obolibrary.org/obo/UBERON_0009570	spinal cord sulcus limitans	http://purl.obolibrary.org/obo/UBERON_0005478	sulcus limitans of neural tube		A sulcus limitans of neural tube that is part of a future spinal cord.
http://purl.obolibrary.org/obo/UBERON_0009572	lumen of central canal of spinal cord	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A cerebrospinal fluid-filled space that runs longitudinally through the length of the entire spinal cord. The central canal is contiguous with the ventricular system of the brain. The central canal represents the adult remainder of the neural tube.
http://purl.obolibrary.org/obo/UBERON_0009576	medulla oblongata sulcus limitans	http://purl.obolibrary.org/obo/UBERON_0005478	sulcus limitans of neural tube		A sulcus limitans of neural tube that is part of a future medulla oblongata.
http://purl.obolibrary.org/obo/UBERON_0009577	metencephalon sulcus limitans	http://purl.obolibrary.org/obo/UBERON_0005478	sulcus limitans of neural tube		A sulcus limitans of neural tube that is part of a future metencephalon.
http://purl.obolibrary.org/obo/UBERON_0009578	myelencephalon sulcus limitans	http://purl.obolibrary.org/obo/UBERON_0005478	sulcus limitans of neural tube		A sulcus limitans of neural tube that is part of a future myelencephalon.
http://purl.obolibrary.org/obo/UBERON_0009584	1st arch mandibular mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010042	1st arch mesenchyme		Mesenchyme that is part of a 1st arch mandibular component.
http://purl.obolibrary.org/obo/UBERON_0009602	left lung associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0004883	lung mesenchyme		Mesenchyme that is part of a developing left lung.
http://purl.obolibrary.org/obo/UBERON_0009603	right lung associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0004883	lung mesenchyme		Mesenchyme that is part of a developing right lung.
http://purl.obolibrary.org/obo/UBERON_0009610	forebrain neural plate	http://purl.obolibrary.org/obo/UBERON_0003075	neural plate		A neural plate that develops_from a future forebrain.
http://purl.obolibrary.org/obo/UBERON_0009611	midbrain neural plate	http://purl.obolibrary.org/obo/UBERON_0003075	neural plate		A neural plate that develops_from a presumptive midbrain.
http://purl.obolibrary.org/obo/UBERON_0009614	hindbrain neural plate	http://purl.obolibrary.org/obo/UBERON_0003075	neural plate		A neural plate that develops_from a presumptive hindbrain.
http://purl.obolibrary.org/obo/UBERON_0009616	presumptive midbrain	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A presumptive structure that has the potential to develop into a midbrain.
http://purl.obolibrary.org/obo/UBERON_0009617	head paraxial mesoderm	http://purl.obolibrary.org/obo/UBERON_0005253	head mesenchyme		Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles.
http://purl.obolibrary.org/obo/UBERON_0009621	tail somite	http://purl.obolibrary.org/obo/UBERON_0002329	somite		A somite that is part of a tail.
http://purl.obolibrary.org/obo/UBERON_0009624	lumbar nerve	http://purl.obolibrary.org/obo/UBERON_0001780	spinal nerve		The lumbar nerves are the five spinal nerves emerging from the lumbar vertebrae. They are divided into posterior and anterior divisions.
http://purl.obolibrary.org/obo/UBERON_0009625	sacral nerve	http://purl.obolibrary.org/obo/UBERON_0001780	spinal nerve		The five sacral nerves emerge from the sacrum. Although the vertebral components of the sacrum are fused into a single bone, the sacral vertebrae are still used to number the sacral nerves. Posteriorly, they emerge from the posterior sacral foramina, and form the posterior branches of sacral nerves. Anteriorly, they emerge from the anterior sacral foramina, and contribute to the sacral plexus (S1-S4) and coccygeal plexus.
http://purl.obolibrary.org/obo/UBERON_0009636	prechordal cartilage	http://purl.obolibrary.org/obo/UBERON_0003932	cartilage element of chondrocranium		Chondrocranium chondrification center that that forms anterior body of sphenoid, containing the sella turcica and posterior body of sphenoid.
http://purl.obolibrary.org/obo/UBERON_0009639	body of sphenoid	http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone		The body of the sphenoid bone, more or less cubical in shape, is hollowed out in its interior to form two large cavities, the sphenoidal air sinuses, which are separated from each other by a septum.
http://purl.obolibrary.org/obo/UBERON_0009640	hypophyseal cartilage	http://purl.obolibrary.org/obo/UBERON_0003932	cartilage element of chondrocranium		Forms around the developing pituitary, and together with prechordal cartilages creates body of sphenoid bone.
http://purl.obolibrary.org/obo/UBERON_0009646	lumbar sympathetic nerve trunk	http://purl.obolibrary.org/obo/UBERON_0004295	sympathetic nerve trunk		A sympathetic nerve trunk that is part of a lower back.
http://purl.obolibrary.org/obo/UBERON_0009647	tympanic membrane epithelium	http://purl.obolibrary.org/obo/UBERON_0015813	middle ear epithelium		One of the two epithelia which make up the tympanic membrane (along with the fibrous layer).
http://purl.obolibrary.org/obo/UBERON_0009648	eyelid subcutaneous connective tissue	http://purl.obolibrary.org/obo/UBERON_0003581	eyelid connective tissue		An eyelid connective tissue that is part of a hypodermis.
http://purl.obolibrary.org/obo/UBERON_0009651	nephron tubule basement membrane	http://purl.obolibrary.org/obo/UBERON_0005769	basement membrane of epithelium		A basement membrane that is part of a nephron tubule.
http://purl.obolibrary.org/obo/UBERON_0009652	bronchus basement membrane	http://purl.obolibrary.org/obo/UBERON_0015329	respiratory system basement membrane		A basement membrane that is part of a bronchus.
http://purl.obolibrary.org/obo/UBERON_0009653	trachea basement membrane	http://purl.obolibrary.org/obo/UBERON_0015329	respiratory system basement membrane		A basement membrane that is part of a trachea.
http://purl.obolibrary.org/obo/UBERON_0009654	alveolar artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		A branch of the maxillary artery that is found in the gingiva, premolars, and molars.
http://purl.obolibrary.org/obo/UBERON_0009655	auricular artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies oxygenated blood to the ear.
http://purl.obolibrary.org/obo/UBERON_0009661	midbrain nucleus	http://purl.obolibrary.org/obo/UBERON_0002308	nucleus of brain		Nucleus located in the midbrain.
http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus	http://purl.obolibrary.org/obo/UBERON_0002308	nucleus of brain		Nucleus located within the hindbrain.
http://purl.obolibrary.org/obo/UBERON_0009663	telencephalic nucleus	http://purl.obolibrary.org/obo/UBERON_0002308	nucleus of brain		A nucleus of brain that is part of a telencephalon.
http://purl.obolibrary.org/obo/UBERON_0009668	ventral mesentery	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		Ventral mesentery is the part of the peritoneum closest to the navel.
http://purl.obolibrary.org/obo/UBERON_0009669	embryonic cloacal lumen	http://purl.obolibrary.org/obo/UBERON_0012463	cloacal lumen		An anatomical space that surrounded_by a embryonic cloaca.
http://purl.obolibrary.org/obo/UBERON_0009670	rectal lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that surrounded_by a rectum.
http://purl.obolibrary.org/obo/UBERON_0009678	tooth row	http://purl.obolibrary.org/obo/UBERON_0034926	anatomical row		Anatomical cluster consisting of adjacent teeth constituting a row.
http://purl.obolibrary.org/obo/UBERON_0009679	set of lower jaw teeth	http://purl.obolibrary.org/obo/UBERON_0009678	tooth row		A tooth row that is part of a skeleton of lower jaw.
http://purl.obolibrary.org/obo/UBERON_0009680	set of upper jaw teeth	http://purl.obolibrary.org/obo/UBERON_0009678	tooth row		A tooth row that is part of a skeleton of upper jaw.
http://purl.obolibrary.org/obo/UBERON_0009692	lumen of pharyngotympanic tube	http://purl.obolibrary.org/obo/UBERON_0005082	tube lumen		An organ cavity that is part of a pharyngotympanic tube.
http://purl.obolibrary.org/obo/UBERON_0009695	epithelium of laryngopharynx	http://purl.obolibrary.org/obo/UBERON_0003351	pharyngeal epithelium		An epithelium that is part of a hypopharynx.
http://purl.obolibrary.org/obo/UBERON_0009712	endocardium of right ventricle	http://purl.obolibrary.org/obo/UBERON_0001081	endocardium of ventricle		Any endocardium that is part of the right ventricle of the heart.
http://purl.obolibrary.org/obo/UBERON_0009713	endocardium of left ventricle	http://purl.obolibrary.org/obo/UBERON_0001081	endocardium of ventricle		Any endocardium that is part of the left ventricle of the heart.
http://purl.obolibrary.org/obo/UBERON_0009714	intermaxillary process	http://purl.obolibrary.org/obo/UBERON_0009292	embryonic nasal process		The primordial mass of tissue formed by the merging of the medial nasal prominences of the embryo; it contributes to the intermaxillary portion of the upper jaw, the prolabial portion of the upper lip, and the primary palate.
http://purl.obolibrary.org/obo/UBERON_0009715	stomodeal lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that surrounded_by a stomodeum.
http://purl.obolibrary.org/obo/UBERON_0009744	lymph node medullary sinus	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels.
http://purl.obolibrary.org/obo/UBERON_0009745	lymph node medullary cord	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node.
http://purl.obolibrary.org/obo/UBERON_0009749	limb mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells.
http://purl.obolibrary.org/obo/UBERON_0009751	cardiac mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures.
http://purl.obolibrary.org/obo/UBERON_0009752	pancreas mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas.
http://purl.obolibrary.org/obo/UBERON_0009758	abdominal ganglion	http://purl.obolibrary.org/obo/UBERON_0007134	trunk ganglion		A ganglion that is part of a abdominal segment of trunk.
http://purl.obolibrary.org/obo/UBERON_0009767	proximal interphalangeal joint	http://purl.obolibrary.org/obo/UBERON_0006658	interphalangeal joint		An inter-phalangeal joint that connects a proximal phalanx to either a medial or distal phalanx.
http://purl.obolibrary.org/obo/UBERON_0009768	distal interphalangeal joint	http://purl.obolibrary.org/obo/UBERON_0006658	interphalangeal joint		An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx.
http://purl.obolibrary.org/obo/UBERON_0009773	renal tubule	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
http://purl.obolibrary.org/obo/UBERON_0009778	pleural sac	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A serous sac that has the pleura and the pleural cavity as parts.
http://purl.obolibrary.org/obo/UBERON_0009841	upper rhombic lip	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		Anterior-most region of dorsal hindbrain within rhombomere 1, adjacent the midbrain-hindbrain boundary.
http://purl.obolibrary.org/obo/UBERON_0009842	glandular acinus	http://purl.obolibrary.org/obo/UBERON_0034922	cell cluster		The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form.
http://purl.obolibrary.org/obo/UBERON_0009843	prostate epithelial cord	http://purl.obolibrary.org/obo/UBERON_0005154	epithelial cord		A solid cord of prostate epithelium.
http://purl.obolibrary.org/obo/UBERON_0009844	urogenital sinus lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that surrounded_by a primitive urogenital sinus.
http://purl.obolibrary.org/obo/UBERON_0009845	urogenital sinus mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that surrounds primitive urogenital sinus.
http://purl.obolibrary.org/obo/UBERON_0009846	embryonic cloacal epithelium	http://purl.obolibrary.org/obo/UBERON_0012481	cloacal epithelium		An epithelium that is part of a embryonic cloaca.
http://purl.obolibrary.org/obo/UBERON_0009847	prostate field	http://purl.obolibrary.org/obo/UBERON_0007688	anlage		A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop.
http://purl.obolibrary.org/obo/UBERON_0009854	digestive tract diverticulum	http://purl.obolibrary.org/obo/UBERON_0009856	sac		Branch or outpocketing of the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0009857	cavum septum pellucidum	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A space enclosed within the laminae of the septum pelludicum, the membranous partition that seperates the frontal horns of the ventricle. contains cerebrospinal fluid (CSF) that filters from the ventricles through the septal laminae. bounded anteriorly by the genu of the corpus callosum; superiorly by the body of the corpus callosum; posteriorly by the anterior limb and pillars of the fornix; inferiorly by the anterior commissure and the rostrum of the corpus callosum; and laterally by the leaflets of the septum pellucidum.
http://purl.obolibrary.org/obo/UBERON_0009859	endosteum	http://purl.obolibrary.org/obo/UBERON_0000158	membranous layer		A thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones.
http://purl.obolibrary.org/obo/UBERON_0009870	zone of stomach	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland.
http://purl.obolibrary.org/obo/UBERON_0009871	nephrogenic zone	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		Outer portion of the renal cortex. Site of formation of medullary and cortical elements.
http://purl.obolibrary.org/obo/UBERON_0009877	metapodium region	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region.
http://purl.obolibrary.org/obo/UBERON_0009878	mesopodial skeleton	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton.
http://purl.obolibrary.org/obo/UBERON_0009879	tarsal skeleton	http://purl.obolibrary.org/obo/UBERON_0009878	mesopodial skeleton		Subdivision of skeleton that consists of endochondral elements distal to the zeugopodial skeletal elements which constitute the proximal region of the posterior autopod skeleton[PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0009880	carpal skeleton	http://purl.obolibrary.org/obo/UBERON_0009878	mesopodial skeleton		Subdivision of skeleton that consists of the endochondral elements distal to the anterior limb/fin zeugopodial skeletal elements which constitute the proximal region of the anterior autopod skeleton[PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0009882	anal column	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal[WP].
http://purl.obolibrary.org/obo/UBERON_0009883	medullary ray	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla.
http://purl.obolibrary.org/obo/UBERON_0009885	interlobar artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that supplies a renal lobe.
http://purl.obolibrary.org/obo/UBERON_0009887	interlobar vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The interlobar veins are veins of the renal circulation which drain the renal lobes.
http://purl.obolibrary.org/obo/UBERON_0009889	secondary heart field	http://purl.obolibrary.org/obo/UBERON_0007688	anlage		A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
http://purl.obolibrary.org/obo/UBERON_0009891	facial mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005253	head mesenchyme		Mesenchyme that is part of a developing face.
http://purl.obolibrary.org/obo/UBERON_0009912	anatomical lobe	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		A portion of an organ, such as the liver, lung, breast, or brain.
http://purl.obolibrary.org/obo/UBERON_0009913	renal lobe	http://purl.obolibrary.org/obo/UBERON_0009912	anatomical lobe		The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP].
http://purl.obolibrary.org/obo/UBERON_0009914	renal lobule	http://purl.obolibrary.org/obo/UBERON_0009911	lobule		The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys.
http://purl.obolibrary.org/obo/UBERON_0009916	wall of ureter	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		An anatomical wall that is part of a ureter.
http://purl.obolibrary.org/obo/UBERON_0009917	kidney corticomedullary boundary	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		The region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary.
http://purl.obolibrary.org/obo/UBERON_0009919	ureter smooth muscle	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		The smooth muscle tissue surrounding the epithelium of the ureter.
http://purl.obolibrary.org/obo/UBERON_0009953	post-embryonic organism	http://purl.obolibrary.org/obo/UBERON_0000468	multicellular organism		A multicellular organism that existence_starts_with a post-embryonic stage.
http://purl.obolibrary.org/obo/UBERON_0009955	neurogenic placode	http://purl.obolibrary.org/obo/UBERON_0002546	cranial placode		Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia.
http://purl.obolibrary.org/obo/UBERON_0009958	bladder lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0009970	epithelium of pancreatic duct	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		An epithelium that is part of a pancreatic duct.
http://purl.obolibrary.org/obo/UBERON_0009972	ureteropelvic junction	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		The junction between the ureter and the renal pelvis of the kidney.
http://purl.obolibrary.org/obo/UBERON_0009973	ureterovesical junction	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		The valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney.
http://purl.obolibrary.org/obo/UBERON_0009979	condyle	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		An articular prominence of a bone, typically present in pairs, resembling a pair of knuckles. Examples: Condyle of humerus, condyle of femur.
http://purl.obolibrary.org/obo/UBERON_0009980	condyle of femur	http://purl.obolibrary.org/obo/UBERON_0009979	condyle		A condyle that is part of a distal epiphysis of femur.
http://purl.obolibrary.org/obo/UBERON_0009984	medial condyle of femur	http://purl.obolibrary.org/obo/UBERON_0009980	condyle of femur		The medial condyle is one of the two projections on the lower extremity of femur. The medial condyle is larger than the lateral (outer) condyle due to more weight bearing caused by the center of gravity being medial to the knee. On the posterior surface of the condyle the linea aspera (a ridge running down the posterior shaft of the femur) turns into the medial supracondylar ridge. The outermost protrusion on the medial surface of the medial condyle is referred to as the 'medial epicondyle' and can be palpated by running fingers medially from the patella with the knee in flexion.
http://purl.obolibrary.org/obo/UBERON_0009988	condyle of humerus	http://purl.obolibrary.org/obo/UBERON_0009979	condyle		The distal end of the humerus, including the trochlea, capitulum and the olecranon, coronoid and radial fossae.
http://purl.obolibrary.org/obo/UBERON_0009989	condyle of tibia	http://purl.obolibrary.org/obo/UBERON_0009979	condyle		One of the lateral or medial condyles of the tibia.
http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that has more than one cell as a part.
http://purl.obolibrary.org/obo/UBERON_0010009	aggregate regional part of brain	http://purl.obolibrary.org/obo/UBERON_0034923	disconnected anatomical group		A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF].
http://purl.obolibrary.org/obo/UBERON_0010020	tubotympanic recess epithelium	http://purl.obolibrary.org/obo/UBERON_0015813	middle ear epithelium		The dorsal portion of the embryonic first endodermal pharyngeal pouch; it develops into the middle ear cavity.
http://purl.obolibrary.org/obo/UBERON_0010031	6th arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009494	pharyngeal arch mesenchymal region		Mesenchyme that is part of a pharyngeal arch 6.
http://purl.obolibrary.org/obo/UBERON_0010032	anterior part of tongue	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The portion of the tongue in front of the terminal sulcus. At the apex, thin and narrow, it is directed forward against the lingual surfaces of the lower incisor teeth. It is derived primarily from the first pharyngeal arch.
http://purl.obolibrary.org/obo/UBERON_0010033	posterior part of tongue	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The Posterior tongue, or pharyngeal part, is the part of the tongue behind the terminal sulcus. At its root, it is directed backward, and connected with the hyoid bone by the Hyoglossi and Genioglossi muscles and the hyoglossal membrane; with the epiglottis by three folds (glossoepiglottic) of mucous membrane; with the soft palate by the glossopalatine arches; and with the pharynx by the Constrictores pharyngis superiores and the mucous membrane. It is derived primarily from the third pharyngeal arch. (The second arch has a substantial contribution during fetal development, but this later atrophies. The fourth arch may also contribute, depending upon how the boundaries of the tongue are defined.).
http://purl.obolibrary.org/obo/UBERON_0010039	food storage organ	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		An organ of the digestive tract that is capable of retaining and storing food.
http://purl.obolibrary.org/obo/UBERON_0010042	1st arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009494	pharyngeal arch mesenchymal region		Mesenchyme that is part of a pharyngeal arch 1.
http://purl.obolibrary.org/obo/UBERON_0010045	1st arch maxillary mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010042	1st arch mesenchyme		Mesenchyme that is part of a 1st arch maxillary component.
http://purl.obolibrary.org/obo/UBERON_0010046	entire pharyngeal arch associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells.
http://purl.obolibrary.org/obo/UBERON_0010047	oral gland	http://purl.obolibrary.org/obo/UBERON_0003408	gland of digestive tract		Gland of the epithelium lining the oral cavity. The most common are the salivary glands.
http://purl.obolibrary.org/obo/UBERON_0010052	mucosa of dorsum of tongue	http://purl.obolibrary.org/obo/UBERON_0005020	mucosa of tongue		A mucosa that is part of a dorsum of tongue.
http://purl.obolibrary.org/obo/UBERON_0010054	malleus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015018	malleus endochondral element		A malleus endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010055	stapes cartilage element	http://purl.obolibrary.org/obo/UBERON_0015016	stapes endochondral element		A stapes endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010056	future tongue	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A compound organ that has the potential to develop into a tongue.
http://purl.obolibrary.org/obo/UBERON_0010060	pharyngeal opening of pharyngotympanic tube	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		On the lateral wall of the nasal part of the pharynx is the pharyngeal opening of auditory tube (pharyngeal ostium), somewhat triangular in shape, and bounded behind by a firm prominence, the torus or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane.
http://purl.obolibrary.org/obo/UBERON_0010064	open anatomical space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space with at least one opening to another space or the exterior.
http://purl.obolibrary.org/obo/UBERON_0010069	outer epithelial layer of tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0015814	outer ear epithelium		A portion of the external acoustic meatus epithelium which makes up the outer (cuticular) layer of the tympanic membrane.
http://purl.obolibrary.org/obo/UBERON_0010070	intermediate layer of tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0010071	layer of tympanic membrane		The intermediate fibrous layer of the tympanic membrane.
http://purl.obolibrary.org/obo/UBERON_0010074	chromaffin system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		Organ system subdivision that consists primarily of chromaffin cells and their supporting structures.
http://purl.obolibrary.org/obo/UBERON_0010075	sacral neural crest	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		One of the 5 distinct and partially overlapping functional domains of the premigratory neural crest. The vagal and sacral neural crest cells develop into the ganglia of the enteric nervous system, also known as the parasympathetic ganglia.
http://purl.obolibrary.org/obo/UBERON_0010076	network of trabecular spaces in bone tissue	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		Tissue cavity consisting of intercommunicating trabecular spaces in the cancellous bone.
http://purl.obolibrary.org/obo/UBERON_0010077	cuboidal epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium consisting of cuboidal epithelial cells.
http://purl.obolibrary.org/obo/UBERON_0010081	future common hepatic duct	http://purl.obolibrary.org/obo/UBERON_0034932	epithelium of biliary system		An extrahepatic bile duct that has the potential to develop into a common hepatic duct.
http://purl.obolibrary.org/obo/UBERON_0010083	future dermis	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that has the potential to develop into a dermis.
http://purl.obolibrary.org/obo/UBERON_0010084	future diaphragm	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A structure that will develop into a diaphragm.
http://purl.obolibrary.org/obo/UBERON_0010090	future falx cerebri	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		A developing anatomical structure that has the potential to develop into a falx cerebri.
http://purl.obolibrary.org/obo/UBERON_0010091	future hindbrain meninx	http://purl.obolibrary.org/obo/UBERON_0007645	future meninx		A multi-tissue structure that has the potential to develop into a meninx of hindbrain.
http://purl.obolibrary.org/obo/UBERON_0010092	future metencephalon	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A developing anatomical structure that has the potential to develop into a metencephalon.
http://purl.obolibrary.org/obo/UBERON_0010096	future myelencephalon	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A developing anatomical structure that has the potential to develop into a myelencephalon.
http://purl.obolibrary.org/obo/UBERON_0010123	future facial nucleus	http://purl.obolibrary.org/obo/UBERON_0002020	gray matter		A gray matter that has the potential to develop into a facial nucleus.
http://purl.obolibrary.org/obo/UBERON_0010125	future superior salivatory nucleus	http://purl.obolibrary.org/obo/UBERON_0002020	gray matter		A gray matter that has the potential to develop into a superior salivatory nucleus.
http://purl.obolibrary.org/obo/UBERON_0010129	femur cartilage element	http://purl.obolibrary.org/obo/UBERON_0015052	femur endochondral element		A femur endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010130	embryonic autopod plate	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The distal elements of the developing limb of vertebrates that will give rise to the autopod (e.g. manus, pes, paw).
http://purl.obolibrary.org/obo/UBERON_0010131	conducting tissue of heart	http://purl.obolibrary.org/obo/UBERON_0001133	cardiac muscle tissue		Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers.
http://purl.obolibrary.org/obo/UBERON_0010133	neuroendocrine gland	http://purl.obolibrary.org/obo/UBERON_0002368	endocrine gland		Any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli.
http://purl.obolibrary.org/obo/UBERON_0010134	secretory circumventricular organ	http://purl.obolibrary.org/obo/UBERON_0010133	neuroendocrine gland		A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid.
http://purl.obolibrary.org/obo/UBERON_0010135	sensory circumventricular organ	http://purl.obolibrary.org/obo/UBERON_0005408	circumventricular organ		A circumventricular organ that is capable of monitoring the levels of substances to the cerebrospinal fluid.
http://purl.obolibrary.org/obo/UBERON_0010141	primitive sex cord of indifferent gonad	http://purl.obolibrary.org/obo/UBERON_0005295	sex cord		A sex cord that is part of a indifferent gonad.
http://purl.obolibrary.org/obo/UBERON_0010143	seminal vesicle fluid	http://purl.obolibrary.org/obo/UBERON_0006530	seminal fluid		A bodily secretion that is produced by a seminal vesicle.
http://purl.obolibrary.org/obo/UBERON_0010147	male accessory sex gland	http://purl.obolibrary.org/obo/UBERON_0005399	male reproductive gland		Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male.
http://purl.obolibrary.org/obo/UBERON_0010152	skin mucus	http://purl.obolibrary.org/obo/UBERON_0000912	mucus		A mucous secretion that is produced by glands in the epidermis.
http://purl.obolibrary.org/obo/UBERON_0010155	parietomastoid suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		Unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP:Squamosal_suture].
http://purl.obolibrary.org/obo/UBERON_0010156	sphenofrontal suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		The Sphenofrontal suture is the cranial suture between the sphenoid bone and the frontal bone.
http://purl.obolibrary.org/obo/UBERON_0010157	sphenoparietal suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		The Sphenoparietal suture is the cranial suture between the sphenoid bone and the parietal bone.
http://purl.obolibrary.org/obo/UBERON_0010158	sphenozygomatic suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		The Sphenozygomatic suture is the cranial suture between the sphenoid bone and the zygomatic bone.
http://purl.obolibrary.org/obo/UBERON_0010160	lumen of lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that surrounded_by a lymphatic vessel.
http://purl.obolibrary.org/obo/UBERON_0010161	lumen of blood vessel	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that surrounded_by a blood vessel.
http://purl.obolibrary.org/obo/UBERON_0010162	post-anal tail tip	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		The distal end of the tail.
http://purl.obolibrary.org/obo/UBERON_0010163	eyebrow	http://purl.obolibrary.org/obo/UBERON_0010165	collection of hair on face		The eyebrow is an area of thick, delicate hairs above the eye that follows the shape of the lower margin of the brow ridges. Their main function is to protect the eye, but they are also important to human communication and facial expression. It is not uncommon for people to modify their eyebrows by means of hair addition or removal, make up, or piercings.
http://purl.obolibrary.org/obo/UBERON_0010164	collection of hairs	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		An anatomical cluster that composed_primarily_of a strand of hair.
http://purl.obolibrary.org/obo/UBERON_0010165	collection of hair on face	http://purl.obolibrary.org/obo/UBERON_0014382	collection of hairs on head or neck		A collection of hairs that is part of a face.
http://purl.obolibrary.org/obo/UBERON_0010168	collection of eyelashes	http://purl.obolibrary.org/obo/UBERON_0010165	collection of hair on face		A collection of hair on face that is part of a eyelash.
http://purl.obolibrary.org/obo/UBERON_0010171	strand of hair of face	http://purl.obolibrary.org/obo/UBERON_0016446	hair of head		A strand of hair that is part of a face.
http://purl.obolibrary.org/obo/UBERON_0010172	bulb of aorta	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles.
http://purl.obolibrary.org/obo/UBERON_0010183	liver trabecula	http://purl.obolibrary.org/obo/UBERON_0000440	trabecula		A trabecula that is part of a liver.
http://purl.obolibrary.org/obo/UBERON_0010186	male urethral gland	http://purl.obolibrary.org/obo/UBERON_0001338	urethral gland		Any of the numerous small mucous-secreting glands located in the wall of the penile urethra.
http://purl.obolibrary.org/obo/UBERON_0010187	female urethral gland	http://purl.obolibrary.org/obo/UBERON_0001338	urethral gland		An urethral gland that is part of a female urethra.
http://purl.obolibrary.org/obo/UBERON_0010188	protuberance	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		A roughly circular bulge in a surface.
http://purl.obolibrary.org/obo/UBERON_0010192	genital artery	http://purl.obolibrary.org/obo/UBERON_0012254	abdominal aorta artery		One of the laterally paired arteries that supply the gonads.
http://purl.obolibrary.org/obo/UBERON_0010194	hepatic portal system	http://purl.obolibrary.org/obo/UBERON_0005806	portal system		A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver.
http://purl.obolibrary.org/obo/UBERON_0010199	bona-fide anatomical boundary	http://purl.obolibrary.org/obo/UBERON_0000466	immaterial anatomical entity		An anatomical boundary that corresponds to some physical discontinuity.
http://purl.obolibrary.org/obo/UBERON_0010204	tail vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		A vasculature that is part of a post-anal tail.
http://purl.obolibrary.org/obo/UBERON_0010210	blood clot	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		A semisolid gelatinous mass of coagulated blood that consists of red blood cells, white blood cells, and platelets entrapped in a fibrin network.
http://purl.obolibrary.org/obo/UBERON_0010212	laryngeal apparatus	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		Apparatus located between the lungs and the buccal cavity. This apparatus is composed of a pair of arytenoid cartilages that are supported by the cricoid ring.
http://purl.obolibrary.org/obo/UBERON_0010215	arytenoid swellings	http://purl.obolibrary.org/obo/UBERON_0005856	developing mesenchymal condensation		Paired primordial elevations, on either side of the embryonic larynx, within which the arytenoid cartilages are formed.
http://purl.obolibrary.org/obo/UBERON_0010223	left pupil	http://purl.obolibrary.org/obo/UBERON_0001771	pupil		A pupil that is part of a left eye.
http://purl.obolibrary.org/obo/UBERON_0010224	right pupil	http://purl.obolibrary.org/obo/UBERON_0001771	pupil		A pupil that is part of a right eye.
http://purl.obolibrary.org/obo/UBERON_0010225	thalamic complex	http://purl.obolibrary.org/obo/UBERON_0019269	gray matter of diencephalon		A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0010227	future cardiac atrium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Multi-tissue structure that is part of the heart tube and will become the cardiac atrium.
http://purl.obolibrary.org/obo/UBERON_0010230	eyeball of camera-type eye	http://purl.obolibrary.org/obo/UBERON_0000020	sense organ		The core globe-shaped component of the camera-type eye.
http://purl.obolibrary.org/obo/UBERON_0010233	stroma of thyroid gland	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		The connective tissue that supports the lobules and follicles of the thyroid gland.
http://purl.obolibrary.org/obo/UBERON_0010234	palatopharyngeus muscle	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The palatopharyngeus or palatopharyngeal or pharyngopalatinus muscle is a long, fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the palatopharyngeal arch.
http://purl.obolibrary.org/obo/UBERON_0010235	uvular muscle	http://purl.obolibrary.org/obo/UBERON_0003682	palatal muscle		The musculus uvulae (azygos uvulae) is a muscle of the soft palate. It arises from the posterior nasal spine of the palatine bones and from the palatine aponeurosis. It descends to be inserted into the uvula and functions to move and shape it. It is innervated by the pharyngeal branch of the vagus nerve via the pharyngeal plexus[WP].
http://purl.obolibrary.org/obo/UBERON_0010243	merocrine gland	http://purl.obolibrary.org/obo/UBERON_0002365	exocrine gland		An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged.
http://purl.obolibrary.org/obo/UBERON_0010252	1st arch mandibular mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010259	1st arch mesenchyme from neural crest		Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010253	1st arch maxillary mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010259	1st arch mesenchyme from neural crest		Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010254	2nd arch mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010359	pharyngeal arch mesenchyme from neural crest		Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010255	3rd arch mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010359	pharyngeal arch mesenchyme from neural crest		Mesenchyme that develops_from a neural crest and is part of a 3rd arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010256	4th arch mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010359	pharyngeal arch mesenchyme from neural crest		Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010257	6th arch mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010359	pharyngeal arch mesenchyme from neural crest		Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010258	mesenchyme from rhombencephalic neural crest	http://purl.obolibrary.org/obo/UBERON_0014387	mesenchyme derived from neural crest		Mesenchyme that develops_from a rhombencephalon neural crest.
http://purl.obolibrary.org/obo/UBERON_0010259	1st arch mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010359	pharyngeal arch mesenchyme from neural crest		Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010260	umbilical blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta.
http://purl.obolibrary.org/obo/UBERON_0010262	operculum of brain	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		The most posterior portion of the inferior frontal gyrus of the frontal lobe in the brain. In an axial plane, the Sylvian fissure extends from the operculum posteriorly to divide the frontal from the temporal lobe. Broca's area is a notable part of the operculum, which plays a key role in conversation or speech production, reading and writing. Its vascular supply comes from the M3 branches of the middle cerebral artery[WP].
http://purl.obolibrary.org/obo/UBERON_0010272	hyoid apparatus	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		A group of bones comprised of hyoid body and two pairs of cornua (i.e. greater cornua and lesser cornua), and lies just below the tongue, above the thyroid cartilage.
http://purl.obolibrary.org/obo/UBERON_0010273	zone of hyoid bone	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		A zone of bone organ that is part of a hyoid bone.
http://purl.obolibrary.org/obo/UBERON_0010276	space in vertebral column	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		Any anatomical space that is part of a vertebral column.
http://purl.obolibrary.org/obo/UBERON_0010284	lacrimal punctum	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		A minute orifice on the summit of the papillae lacrimales, which is the commencement point of the lacrimal canaliculi.
http://purl.obolibrary.org/obo/UBERON_0010285	midbrain basal plate	http://purl.obolibrary.org/obo/UBERON_0002020	gray matter		Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.
http://purl.obolibrary.org/obo/UBERON_0010286	midbrain neural tube	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Portion of neural tube that gives rise to the midbrain.
http://purl.obolibrary.org/obo/UBERON_0010294	scleral endothelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		An endothelium that is part of a sclera.
http://purl.obolibrary.org/obo/UBERON_0010295	substantia propria of sclera	http://purl.obolibrary.org/obo/UBERON_0010291	layer of sclera		A stroma that is part of a sclera.
http://purl.obolibrary.org/obo/UBERON_0010299	scleral mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme surrounding the developing optic cup which develops into the sclera.
http://purl.obolibrary.org/obo/UBERON_0010303	extraembryonic epithelium	http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue		An epithelium that is part of a extraembryonic structure.
http://purl.obolibrary.org/obo/UBERON_0010304	non-keratinized stratified squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006915	stratified squamous epithelium		Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus.
http://purl.obolibrary.org/obo/UBERON_0010305	subdivision of conjunctiva	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		One of the three major regions of the conjunctiva.
http://purl.obolibrary.org/obo/UBERON_0010306	bulbar conjunctiva	http://purl.obolibrary.org/obo/UBERON_0010305	subdivision of conjunctiva		The conjunctiva covering the anterior surface of the sclera and the surface epithelium of the cornea.
http://purl.obolibrary.org/obo/UBERON_0010309	palpebral bone	http://purl.obolibrary.org/obo/UBERON_0010321	skeletal element of eye region		An ossified element investing the upper eyelid.
http://purl.obolibrary.org/obo/UBERON_0010312	immature eye	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		Developing anatomical structure that develops into the eyeball and associated structures.
http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		An anatomical structure that develops from the neural crest.
http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that has some part that develops from the neural crest.
http://purl.obolibrary.org/obo/UBERON_0010321	skeletal element of eye region	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		A skeletal element that is part of a orbital region.
http://purl.obolibrary.org/obo/UBERON_0010323	cranial skeletal system	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
http://purl.obolibrary.org/obo/UBERON_0010328	limb bud mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010329	paired limb/fin bud mesenchyme		Mesenchyme that is part of a limb bud.
http://purl.obolibrary.org/obo/UBERON_0010329	paired limb/fin bud mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010377	mesenchyme from somatopleure		Mesenchyme that is part of a limb/fin bud.
http://purl.obolibrary.org/obo/UBERON_0010330	eyelid mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003314	eye mesenchyme		Mesenchyme that is part of a developing eyelid.
http://purl.obolibrary.org/obo/UBERON_0010332	epithelium of handplate	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An epithelium that is part of a handplate.
http://purl.obolibrary.org/obo/UBERON_0010333	extraembryonic membrane mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue		Mesenchyme that is part of a extraembryonic membrane.
http://purl.obolibrary.org/obo/UBERON_0010334	maxillary process mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010258	mesenchyme from rhombencephalic neural crest		Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010335	maxillary process mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009526	maxillary process mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010336	mandibular process mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010258	mesenchyme from rhombencephalic neural crest		Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010337	mandibular process mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0006905	mandibular process mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010338	1st arch maxillary mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010341	1st arch mesenchyme from head mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010339	1st arch mandibular mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010341	1st arch mesenchyme from head mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010341	1st arch mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010360	pharyngeal arch mesenchyme from head mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010343	2nd arch mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010360	pharyngeal arch mesenchyme from head mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010344	3rd arch mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010360	pharyngeal arch mesenchyme from head mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 3rd arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010345	4th arch mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010360	pharyngeal arch mesenchyme from head mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010347	6th arch mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010360	pharyngeal arch mesenchyme from head mesenchyme		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010349	otic capsule pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0004637	otic capsule		An otic capsule endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0010355	ossification center	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed a ossification center, enlarge and arrange themselves in rows. The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other. A deposit of calcareous material now takes place in this matrix, between the rows of cells, so that they become separated from each other by longitudinal columns of calcified matrix, presenting a granular and opaque appearance. Here and there the matrix between two cells of the same row also becomes calcified, and transverse bars of calcified substance stretch across from one calcareous column to another. Thus there are longitudinal groups of the cartilage cells enclosed in oblong cavities, the walls of which are formed of calcified matrix which cuts off all nutrition from the cells; the cells, in consequence, atrophy, leaving spaces called the primary areolC&.
http://purl.obolibrary.org/obo/UBERON_0010358	arch of centrum of vertebra	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		An arch-shaped structure of the vertebra that extends dorsally (neural arch) or ventrally (hemal arch) from the vertebral centrum.
http://purl.obolibrary.org/obo/UBERON_0010359	pharyngeal arch mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0014387	mesenchyme derived from neural crest		Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010360	pharyngeal arch mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010362	endoskeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues.
http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification.
http://purl.obolibrary.org/obo/UBERON_0010364	dermal skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements.
http://purl.obolibrary.org/obo/UBERON_0010365	odontoid tissue	http://purl.obolibrary.org/obo/UBERON_0004755	skeletal tissue		Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla.
http://purl.obolibrary.org/obo/UBERON_0010366	conjunctival vasculature	http://purl.obolibrary.org/obo/UBERON_0002203	vasculature of eye		A vasculature that is part of a conjunctiva.
http://purl.obolibrary.org/obo/UBERON_0010367	conjunctival vein	http://purl.obolibrary.org/obo/UBERON_0009141	craniocervical region vein		A vein that is part of a conjunctiva.
http://purl.obolibrary.org/obo/UBERON_0010368	pulmonary lobule	http://purl.obolibrary.org/obo/UBERON_0009911	lobule		The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa.
http://purl.obolibrary.org/obo/UBERON_0010369	secondary pulmonary lobule	http://purl.obolibrary.org/obo/UBERON_0010368	pulmonary lobule		A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa.
http://purl.obolibrary.org/obo/UBERON_0010370	tibial vein	http://purl.obolibrary.org/obo/UBERON_0003503	leg blood vessel		One of the veins of the lower leg; empty into the popliteal vein.
http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		Epithelium composed of cells that develops from the ectoderm[FMA,modified].
http://purl.obolibrary.org/obo/UBERON_0010377	mesenchyme from somatopleure	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		Mesenchyme that develops_from a somatopleure.
http://purl.obolibrary.org/obo/UBERON_0010378	mesenchyme from splanchnopleure	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		Mesenchyme that develops_from a splanchnopleure.
http://purl.obolibrary.org/obo/UBERON_0010379	superior tarsal muscle	http://purl.obolibrary.org/obo/UBERON_0003386	smooth muscle of eye		The superior tarsal muscle is a smooth muscle adjoining the levator palpebrae superioris muscle that helps to raise the upper eyelid.
http://purl.obolibrary.org/obo/UBERON_0010380	enteric nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		The neurons that innervate the esophagus, stomach, small and large bowel.
http://purl.obolibrary.org/obo/UBERON_0010384	lumen of laryngopharynx	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a hypopharynx.
http://purl.obolibrary.org/obo/UBERON_0010388	proximal segment of rib	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The segment of the rib that connects to a vertebra[MP]. a small part of the rib composed of the head, neck, tuberculum and a short proximal part of the body[PMID].
http://purl.obolibrary.org/obo/UBERON_0010390	lumen of urethra	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An organ cavity that is part of a urethra.
http://purl.obolibrary.org/obo/UBERON_0010395	lymph node primary follicle	http://purl.obolibrary.org/obo/UBERON_0010748	lymph node follicle		An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex.
http://purl.obolibrary.org/obo/UBERON_0010399	spleen trabecular artery	http://purl.obolibrary.org/obo/UBERON_0003497	abdomen blood vessel		One of the branches of the splenic artery[MP].
http://purl.obolibrary.org/obo/UBERON_0010400	spleen trabecular vein	http://purl.obolibrary.org/obo/UBERON_0013126	vein of abdomen		One of the veins that feed the splenic vein.
http://purl.obolibrary.org/obo/UBERON_0010402	epidermis suprabasal layer	http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer		Any layer of the epidermis that is superior to the stratum basale.
http://purl.obolibrary.org/obo/UBERON_0010408	ocular angle artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The angular artery is the terminal part of the facial artery; it ascends to the medial angle of the eye's orbit, imbedded in the fibers of the angular head of the Quadratus labii superioris, and accompanied by the angular vein.
http://purl.obolibrary.org/obo/UBERON_0010409	ocular surface region	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms.
http://purl.obolibrary.org/obo/UBERON_0010411	retroperitoneal fat pad	http://purl.obolibrary.org/obo/UBERON_0003427	abdominal fat pad		Encapsulated adipose tissue found on the dorsal side of the peritoneum.
http://purl.obolibrary.org/obo/UBERON_0010412	epididymal fat pad	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Encapsulated adipose tissue associated with the epididymis.
http://purl.obolibrary.org/obo/UBERON_0010418	urethral opening	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		An orifice that is part of a lower urinary tract.
http://purl.obolibrary.org/obo/UBERON_0010420	lymph node germinal center mantle zone	http://purl.obolibrary.org/obo/UBERON_0010755	secondary follicle corona		A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it.
http://purl.obolibrary.org/obo/UBERON_0010421	spleen B cell corona	http://purl.obolibrary.org/obo/UBERON_0010755	secondary follicle corona		The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes.
http://purl.obolibrary.org/obo/UBERON_0010422	primary nodular lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0000444	lymphoid follicle		A lymphoid follicle containing naive B cells.
http://purl.obolibrary.org/obo/UBERON_0010423	primary lymphoid nodule of tonsil	http://purl.obolibrary.org/obo/UBERON_0010422	primary nodular lymphoid tissue		A primary nodular lymphoid tissue that is part of a tonsil.
http://purl.obolibrary.org/obo/UBERON_0010425	internal naris	http://purl.obolibrary.org/obo/UBERON_0000003	naris		A naris that is located inside the nasal cavity and connects to the pharynx.
http://purl.obolibrary.org/obo/UBERON_0010427	ciliary processes	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens.
http://purl.obolibrary.org/obo/UBERON_0010428	flat bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow.
http://purl.obolibrary.org/obo/UBERON_0010437	zygomaticus muscle	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		One of: zygomaticus major, zygomaticus minor.
http://purl.obolibrary.org/obo/UBERON_0010498	pseudostratified columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0000485	simple columnar epithelium		A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels.
http://purl.obolibrary.org/obo/UBERON_0010499	pseudostratified ciliated columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0010498	pseudostratified columnar epithelium		Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile.
http://purl.obolibrary.org/obo/UBERON_0010522	replacement element	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Skeletal element that forms as a replacement or substitution of another element or tissue.
http://purl.obolibrary.org/obo/UBERON_0010523	microcirculatory vessel	http://purl.obolibrary.org/obo/UBERON_0000055	vessel		A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses.
http://purl.obolibrary.org/obo/UBERON_0010527	cavity of bone organ	http://purl.obolibrary.org/obo/UBERON_0002558	organ cavity		An organ cavity that surrounded_by a bone.
http://purl.obolibrary.org/obo/UBERON_0010532	primitive nephron	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		An epithelial tube that is fated to become a nephron.
http://purl.obolibrary.org/obo/UBERON_0010533	metanephros cortex	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		The metanephric cortex is the outer region of the metanephros[GO].
http://purl.obolibrary.org/obo/UBERON_0010534	primitive mesonephric nephron	http://purl.obolibrary.org/obo/UBERON_0010532	primitive nephron		Anatomical cluster which give rise to mature mesonephric nephrons. Zebrafish continously generate new mesonephric nephrons.
http://purl.obolibrary.org/obo/UBERON_0010535	primitive metanephric nephron	http://purl.obolibrary.org/obo/UBERON_0010532	primitive nephron		A primitive nephron that is part of a metanephros.
http://purl.obolibrary.org/obo/UBERON_0010537	mesonephric nephron progenitor	http://purl.obolibrary.org/obo/UBERON_0010536	nephron progenitor		Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells.
http://purl.obolibrary.org/obo/UBERON_0010538	paired limb/fin segment	http://purl.obolibrary.org/obo/UBERON_0010758	subdivision of organism along appendicular axis		An appendage segment that is part of a limb/fin.
http://purl.obolibrary.org/obo/UBERON_0010540	tarsus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015050	tarsus endochondral element		A pre-cartilage condensation that has the potential to develop into a tarsal bone.
http://purl.obolibrary.org/obo/UBERON_0010541	tarsus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015050	tarsus endochondral element		A cartilaginous condensation that has the potential to develop into a tarsal bone.
http://purl.obolibrary.org/obo/UBERON_0010543	acropodial skeleton	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified].
http://purl.obolibrary.org/obo/UBERON_0010544	metacarpus skeleton	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		The metacarpus is the intermediate part of the manus skeleton that is located between the phalanges (bones of the fingers) distally and the carpus which forms the connection to the forearm. The metacarpus consists of metacarpal bones. The metacarpals form a transverse arch to which the rigid row of distal carpal bones are fixed. The peripheral metacarpals (those of the thumb and little finger) form the sides of the cup of the palmar gutter and as they are brought together they deepen this concavity. The index metacarpal is the most firmly fixed, while the thumb metacarpal articulates with the trapezium and acts independently from the others. The middle metacarpals are tightly united to the carpus by intrinsic interlocking bone elements at their bases. The ring metacarpal forms a transitional element of the semi-independent last metacarpal. [WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0010545	metatarsus skeleton	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		Limb segment that consists of the long bones of the pes. The metatarsals are analogous to the metacarpal bones of the manus.
http://purl.obolibrary.org/obo/UBERON_0010546	metapodial skeleton	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton.
http://purl.obolibrary.org/obo/UBERON_0010547	pedal digit 1 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015037	pedal digit 1 metatarsal endochondral element		A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010548	pedal digit 2 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015038	pedal digit 2 metatarsal endochondral element		A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010549	pedal digit 3 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015039	pedal digit 3 metatarsal endochondral element		A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010550	pedal digit 4 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015040	pedal digit 4 metatarsal endochondral element		A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010551	pedal digit 5 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015041	pedal digit 5 metatarsal endochondral element		A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010557	pedal digit 1 metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0015037	pedal digit 1 metatarsal endochondral element		A pedal digit metatarsal cartilage condensation that is part of a pedal digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010558	pedal digit 2 metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0015038	pedal digit 2 metatarsal endochondral element		A pedal digit metatarsal cartilage element that is part of a pedal digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010559	pedal digit 3 metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0015039	pedal digit 3 metatarsal endochondral element		A pedal digit metatarsal cartilage element that is part of a pedal digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010560	pedal digit 4 metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0015040	pedal digit 4 metatarsal endochondral element		A pedal digit metatarsal cartilage element that is part of a pedal digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010561	pedal digit 5 metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0015041	pedal digit 5 metatarsal endochondral element		A pedal digit metatarsal cartilage element that is part of a pedal digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010562	pedal digit 1 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005255	pedal digit mesenchyme		Mesenchyme that is part of a developing pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0010564	manual digit 1 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005257	manual digit mesenchyme		Mesenchyme that is part of a developing manual digit 1.
http://purl.obolibrary.org/obo/UBERON_0010565	manual digit 1 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015043	manual digit 1 metacarpus endochondral element		A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010566	manual digit 2 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015044	manual digit 2 metacarpus endochondral element		A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010567	manual digit 3 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015045	manual digit 3 metacarpus endochondral element		A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010568	manual digit 4 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015046	manual digit 4 metacarpus endochondral element		A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010569	manual digit 5 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015047	manual digit 5 metacarpus endochondral element		A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010570	manual digit 1 metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015043	manual digit 1 metacarpus endochondral element		A manual digit metacarpus cartilage element that is part of a manual digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010571	manual digit 2 metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015044	manual digit 2 metacarpus endochondral element		A manual digit metacarpus cartilage element that is part of a manual digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010572	manual digit 3 metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015045	manual digit 3 metacarpus endochondral element		A manual digit metacarpus cartilage element that is part of a manual digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010573	manual digit 4 metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015046	manual digit 4 metacarpus endochondral element		A manual digit metacarpus cartilage element that is part of a manual digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010574	manual digit 5 metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015047	manual digit 5 metacarpus endochondral element		A manual digit metacarpus cartilage element that is part of a manual digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010575	manual digit 1 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015025	manual digit 1 phalanx endochondral element		A pre-cartilage condensation that is part of a manual digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010576	manual digit 2 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015026	manual digit 2 phalanx endochondral element		A pre-cartilage condensation that is part of a manual digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010577	manual digit 3 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015027	manual digit 3 phalanx endochondral element		A pre-cartilage condensation that is part of a manual digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010578	manual digit 4 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015028	manual digit 4 phalanx endochondral element		A pre-cartilage condensation that is part of a manual digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010579	manual digit 5 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015029	manual digit 5 phalanx endochondral element		A pre-cartilage condensation that is part of a manual digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010580	pedal digit 1 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015031	pedal digit 1 phalanx endochondral element		A pre-cartilage condensation that is part of a pedal digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010581	pedal digit 2 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015032	pedal digit 2 phalanx endochondral element		A pre-cartilage condensation that is part of a pedal digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010582	pedal digit 3 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015033	pedal digit 3 phalanx endochondral element		A pre-cartilage condensation that is part of a pedal digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010583	pedal digit 4 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015034	pedal digit 4 phalanx endochondral element		A pre-cartilage condensation that is part of a pedal digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010584	pedal digit 5 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015035	pedal digit 5 phalanx endochondral element		A pre-cartilage condensation that is part of a pedal digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010585	pedal digit phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element		A pre-cartilage condensation that is part of a pedal digit mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010586	manual digit phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element		A pre-cartilage condensation that is part of a manual digit mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010675	manual digit 1 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015025	manual digit 1 phalanx endochondral element		A cartilage element that is part of a manual digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010676	manual digit 2 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015026	manual digit 2 phalanx endochondral element		A cartilage element that is part of a manual digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010677	manual digit 3 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015027	manual digit 3 phalanx endochondral element		A cartilage element that is part of a manual digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010678	manual digit 4 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015028	manual digit 4 phalanx endochondral element		A cartilage element that is part of a manual digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010679	manual digit 5 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015029	manual digit 5 phalanx endochondral element		A cartilage element that is part of a manual digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010680	pedal digit 1 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015031	pedal digit 1 phalanx endochondral element		A cartilage element that is part of a pedal digit 1 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010681	pedal digit 2 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015032	pedal digit 2 phalanx endochondral element		A cartilage element that is part of a pedal digit 2 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010682	pedal digit 3 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015033	pedal digit 3 phalanx endochondral element		A cartilage element that is part of a pedal digit 3 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010683	pedal digit 4 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015034	pedal digit 4 phalanx endochondral element		A cartilage element that is part of a pedal digit 4 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010684	pedal digit 5 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015035	pedal digit 5 phalanx endochondral element		A cartilage element that is part of a pedal digit 5 mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010685	pedal digit phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0035129	pes cartilage element		A cartilage element that is part of a pedal digit mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010686	manual digit phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		A cartilage element that is part of a manual digit mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0010688	skeleton of manual acropodium	http://purl.obolibrary.org/obo/UBERON_0010543	acropodial skeleton		The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the manual autopodium - i.e. the bones of the hands or their cartilaginous precursors[VSAO,modified].
http://purl.obolibrary.org/obo/UBERON_0010690	manual digit 1 epithelium	http://purl.obolibrary.org/obo/UBERON_0005227	manual digit epithelium		An epithelium that is part of a manual digit 1.
http://purl.obolibrary.org/obo/UBERON_0010693	pedal digit 1 epithelium	http://purl.obolibrary.org/obo/UBERON_0005226	pedal digit epithelium		An epithelium that is part of a pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0010695	mesenchyme of tarsal region	http://purl.obolibrary.org/obo/UBERON_0003860	hindlimb mesenchyme		Mesenchyme of the carpal region that contributes to the tarsal skeleton.
http://purl.obolibrary.org/obo/UBERON_0010696	skeleton of pedal acropodium	http://purl.obolibrary.org/obo/UBERON_0010543	acropodial skeleton		The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the pedal autopodium - i.e. the bones of the foot or their cartilaginous precursors[cjm].
http://purl.obolibrary.org/obo/UBERON_0010702	digit mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009749	limb mesenchyme		Mesenchyme of the digit region.
http://purl.obolibrary.org/obo/UBERON_0010703	forelimb zeugopod skeleton	http://purl.obolibrary.org/obo/UBERON_0011584	zeugopodial skeleton		The collection of all skeletal elements in an forelimb zeugopod region.
http://purl.obolibrary.org/obo/UBERON_0010707	appendage girdle complex	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).
http://purl.obolibrary.org/obo/UBERON_0010708	pectoral complex	http://purl.obolibrary.org/obo/UBERON_0010707	appendage girdle complex		Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle.
http://purl.obolibrary.org/obo/UBERON_0010709	pelvic complex	http://purl.obolibrary.org/obo/UBERON_0010707	appendage girdle complex		Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle.
http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Skeletal subdivision that is a segment of the limb skeleton.
http://purl.obolibrary.org/obo/UBERON_0010714	iliac cartilage element	http://purl.obolibrary.org/obo/UBERON_0015054	iliac endochondral element		An iliac endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010718	pubic cartilage element	http://purl.obolibrary.org/obo/UBERON_0015055	pubic endochondral element		A pubic endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010719	girdle skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		The subdivision of the skeleton of either the pectoral or pelvic girdle.
http://purl.obolibrary.org/obo/UBERON_0010720	hindlimb zeugopod skeleton	http://purl.obolibrary.org/obo/UBERON_0011584	zeugopodial skeleton		Subdivision of skeleton consisting of all skeletal elements in an hindlimb zeugopod region. Typically consists of the tibia and the fibula.
http://purl.obolibrary.org/obo/UBERON_0010721	distal tarsal bone	http://purl.obolibrary.org/obo/UBERON_0018102	distal mesopodial bone		There are three cuneiform bones in the human foot: the medial cuneiform the intermediate cuneiform also known as the middle the lateral cuneiform. They are located between the navicular bone and the first, second and third metatarsal bones and are medial to the cuboid bone[WP, unvetted, human specific].
http://purl.obolibrary.org/obo/UBERON_0010728	sphenoid lesser wing pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015059	orbitosphenoid endochondral element		An orbitosphenoid endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0010737	distal tarsal bone 4	http://purl.obolibrary.org/obo/UBERON_0015111	distal tarsal bone 4 endochondral element		Endochondral tarsal bone articulating with centralia and metatarsal 4.
http://purl.obolibrary.org/obo/UBERON_0010738	distal tarsal bone 5	http://purl.obolibrary.org/obo/UBERON_0015114	distal tarsal bone 5 endochondral element		Endochondral tarsal bone articulating with centralia and metatarsal 5.
http://purl.obolibrary.org/obo/UBERON_0010740	bone of appendage girdle complex	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle).
http://purl.obolibrary.org/obo/UBERON_0010741	bone of pectoral complex	http://purl.obolibrary.org/obo/UBERON_0010740	bone of appendage girdle complex		A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin.
http://purl.obolibrary.org/obo/UBERON_0010742	bone of pelvic complex	http://purl.obolibrary.org/obo/UBERON_0010740	bone of appendage girdle complex		A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle.
http://purl.obolibrary.org/obo/UBERON_0010744	sacral vertebra pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015010	sacral vertebra endochondral element		A sacral vertebra endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0010745	sacral vertebra cartilage element	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		A sacral vertebra endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010746	iliac blade	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The extension of the ilium above the level of the acetabulum. Attachment site for both hindlimb and caudal musculature. Medially is the site of attachment of the sacral ribs, where these exist[PHENOSCAPE:ad].
http://purl.obolibrary.org/obo/UBERON_0010747	body of ilium	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The body of ilium enters into the formation of the acetabulum, of which it forms rather less than two-fifths. Its external surface is partly articular, partly non-articular; the articular segment forms part of the lunate surface of the acetabulum, the non-articular portion contributes to the acetabular fossa. The internal surface of the body is part of the wall of the lesser pelvis and gives origin to some fibers of the Obturator internus. Below, it is continuous with the pelvic surfaces of the ischium and pubis, only a faint line indicating the place of union.
http://purl.obolibrary.org/obo/UBERON_0010748	lymph node follicle	http://purl.obolibrary.org/obo/UBERON_0000444	lymphoid follicle		A lymphoid follicle that is part of a lymph node.
http://purl.obolibrary.org/obo/UBERON_0010753	lymph node secondary follicle	http://purl.obolibrary.org/obo/UBERON_0010748	lymph node follicle		A secondary follicle that is located in a lymph node.
http://purl.obolibrary.org/obo/UBERON_0010754	germinal center	http://purl.obolibrary.org/obo/UBERON_0001744	lymphoid tissue		A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center.
http://purl.obolibrary.org/obo/UBERON_0010755	secondary follicle corona	http://purl.obolibrary.org/obo/UBERON_0001744	lymphoid tissue		The part of the secondary follicle that surrounds the germinal center.
http://purl.obolibrary.org/obo/UBERON_0010758	subdivision of organism along appendicular axis	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg.
http://purl.obolibrary.org/obo/UBERON_0010760	supraglenoid tubercle	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		The supraglenoid tubercle is a region of the scapula to which the long head of the biceps brachii muscle attaches.
http://purl.obolibrary.org/obo/UBERON_0010801	calcaneum pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015014	calcaneum endochondral element		A calcaneum endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0010842	calcaneum cartilage element	http://purl.obolibrary.org/obo/UBERON_0035129	pes cartilage element		A calcaneum endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010843	clavicle cartilage element	http://purl.obolibrary.org/obo/UBERON_0005863	cartilaginous condensation		A cartilaginous condensation that has the potential to develop into a clavicle.
http://purl.obolibrary.org/obo/UBERON_0010844	clavicle pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0005866	pre-cartilage condensation		A pre-cartilage condensation that has the potential to develop into a clavicle.
http://purl.obolibrary.org/obo/UBERON_0010846	radius pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015001	radius endochondral element		A pre-cartilage condensation that has the potential to develop into a radius bone.
http://purl.obolibrary.org/obo/UBERON_0010847	ulna pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015003	ulna endochondral element		A pre-cartilage condensation that has the potential to develop into a ulna.
http://purl.obolibrary.org/obo/UBERON_0010848	radius-ulna cartilage element	http://purl.obolibrary.org/obo/UBERON_0015002	radius-ulna endochondral element		A radius-ulna endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010849	tibia cartilage element	http://purl.obolibrary.org/obo/UBERON_0015004	tibia endochondral element		A cartilaginous condensation that has the potential to develop into a tibia.
http://purl.obolibrary.org/obo/UBERON_0010850	tibia pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015004	tibia endochondral element		A pre-cartilage condensation that has the potential to develop into a tibia.
http://purl.obolibrary.org/obo/UBERON_0010851	fibula cartilage element	http://purl.obolibrary.org/obo/UBERON_0015013	fibula endochondral element		A cartilaginous condensation that has the potential to develop into a fibula.
http://purl.obolibrary.org/obo/UBERON_0010852	fibula pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015013	fibula endochondral element		A pre-cartilage condensation that has the potential to develop into a fibula.
http://purl.obolibrary.org/obo/UBERON_0010879	tusk	http://purl.obolibrary.org/obo/UBERON_0001091	calcareous tooth		A calcareous tooth that is elongated and protrudes from the mouth.
http://purl.obolibrary.org/obo/UBERON_0010881	limb cartilage element	http://purl.obolibrary.org/obo/UBERON_0015061	limb endochondral element		A skeletal element that is part of a limb and composed of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010882	limb bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015061	limb endochondral element		A skeletal element that is part of a limb and composed of pre-cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0010883	forelimb cartilage element	http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element		A cartilaginous condensation that has the potential to develop into a forelimb bone.
http://purl.obolibrary.org/obo/UBERON_0010884	forelimb bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element		A pre-cartilage condensation that has the potential to develop into a forelimb bone.
http://purl.obolibrary.org/obo/UBERON_0010885	hindlimb cartilage element	http://purl.obolibrary.org/obo/UBERON_0015022	hindlimb endochondral element		A cartilaginous condensation that has the potential to develop into a hindlimb bone.
http://purl.obolibrary.org/obo/UBERON_0010886	hindlimb pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015022	hindlimb endochondral element		A pre-cartilage condensation that has the potential to develop into a hindlimb bone.
http://purl.obolibrary.org/obo/UBERON_0010887	tragus	http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head		A small pointed eminence of the external ear, situated in front of the concha, and projecting backward over the meatus.
http://purl.obolibrary.org/obo/UBERON_0010890	pelvic complex muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Muscles of the pelvic girdle, hindlimb or pelvic fin.
http://purl.obolibrary.org/obo/UBERON_0010891	pectoral complex muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		A muscle of a pectoral girdle, pectoral fin or anterior limb.
http://purl.obolibrary.org/obo/UBERON_0010893	median external naris	http://purl.obolibrary.org/obo/UBERON_0005928	external naris		Am unpaired external naris that lies in the midline of the head.
http://purl.obolibrary.org/obo/UBERON_0010899	synchronous hermaphroditic organism	http://purl.obolibrary.org/obo/UBERON_0007197	hermaphroditic organism		Hermaphroditic organism that produces both male and female gametes at the same time.
http://purl.obolibrary.org/obo/UBERON_0010905	clavicle bone primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		A primordium that develops into a clavicle bone.
http://purl.obolibrary.org/obo/UBERON_0010911	ossicle	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Skeletal element that is often isolated, small, and variable in composition.
http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Skeletal element that forms around the notochord and is part of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0010932	crico-arytenoid muscle	http://purl.obolibrary.org/obo/UBERON_0006328	laryngeal intrinsic muscle		Cricoarytenoid muscles are muscles that connect the cricoid cartilage and arytenoid cartilage. More specifically, it can refer to: Posterior cricoarytenoid muscle Lateral cricoarytenoid muscle.
http://purl.obolibrary.org/obo/UBERON_0010933	orbicularis oris muscle	http://purl.obolibrary.org/obo/UBERON_0001577	facial muscle		The orbicularis oris is a superficial facial muscle with fibers that encircle the opening of the oral cavity that attaches to the maxilla, mandible, skin and modiolus, and that participates in oral/pharyngeal behaviors, and is innervated by the facial nerve (CN VII).
http://purl.obolibrary.org/obo/UBERON_0010940	muscle of digastric group	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Either of the two muscles that comprise the digastric group (anterior or posterior).
http://purl.obolibrary.org/obo/UBERON_0010943	anterior digastric muscle	http://purl.obolibrary.org/obo/UBERON_0018544	trigeminal nerve muscle		The anterior digastric is a pharyngeal arch I muscle that participates in oral/pharygeal behaviors and is innervated by the nerve to mylohyoid (a branch of the third division of the trigeminal nerve), is attached to the mandible and to the hyoid apparatus, and it is superficial to mylohyoid muscle.
http://purl.obolibrary.org/obo/UBERON_0010946	occipitofrontalis muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		The occipitofrontalis or epicranius is a muscle which covers parts of the skull. It consists of two parts or bellies: The occipital belly, near the occipital bone, and the frontal belly, near the frontal bone.
http://purl.obolibrary.org/obo/UBERON_0010948	cleidooccipital muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		A muscle organ that attaches_to a clavicle and attaches_to a occipital bone.
http://purl.obolibrary.org/obo/UBERON_0010949	sternooccipital muscle	http://purl.obolibrary.org/obo/UBERON_0002377	muscle of neck		A muscle organ that has_muscle_insertion a occipital bone and has_muscle_origin a sternum.
http://purl.obolibrary.org/obo/UBERON_0010952	frontalis muscle belly	http://purl.obolibrary.org/obo/UBERON_0010938	muscle belly		A belly of the occipitofrontalis muscle that is near the frontal bone.
http://purl.obolibrary.org/obo/UBERON_0010953	nasalis muscle	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The nasalis (compressor naris) is a sphincter-like muscle of the nose whose function is to compress the nasal cartilage. It consists of two parts, transverse and alar: The transverse part arises from the maxilla, above and lateral to the incisive fossa; its fibers proceed upward and medially, expanding into a thin aponeurosis which is continuous on the bridge of the nose with that of the muscle of the opposite side, and with the aponeurosis of the Procerus. The alar part is attached at one end to the greater alar cartilage, and at the other to the integument at the point of the nose. Other sources divide it into 'Compressor nasalis' and 'Dilator nasalis'.
http://purl.obolibrary.org/obo/UBERON_0010959	craniocervical muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Any muscle organ that is part of either the head or the neck.
http://purl.obolibrary.org/obo/UBERON_0011004	pharyngeal arch cartilage	http://purl.obolibrary.org/obo/UBERON_0003933	cranial cartilage		A cartilage element that is part of a splanchnocranium.
http://purl.obolibrary.org/obo/UBERON_0011024	extrinsic extensor muscle of manus	http://purl.obolibrary.org/obo/UBERON_0004254	forelimb zeugopod muscle		The extrinsic extensor muscles of the hand are located in the back of the forearm and have long tendons connecting them to bones in the hand, where they exert their action.
http://purl.obolibrary.org/obo/UBERON_0011085	palatoquadrate arch	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG].
http://purl.obolibrary.org/obo/UBERON_0011088	ligament of knee joint	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		A ligament that is part of a knee joint.
http://purl.obolibrary.org/obo/UBERON_0011090	skeleton of right pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0007832	pelvic girdle skeleton		A skeleton of pelvic girdle that is part of a right pelvic girdle region.
http://purl.obolibrary.org/obo/UBERON_0011091	skeleton of left pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0007832	pelvic girdle skeleton		A skeleton of pelvic girdle that is part of a left pelvic girdle region.
http://purl.obolibrary.org/obo/UBERON_0011092	right pelvic girdle region	http://purl.obolibrary.org/obo/UBERON_0001271	pelvic girdle region		A pelvic girdle region that is in the right side of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0011093	left pelvic girdle region	http://purl.obolibrary.org/obo/UBERON_0001271	pelvic girdle region		A pelvic girdle region that is in the left side of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0011094	vertebra cartilage element	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0011095	vertebra pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0011096	lacrimal nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The lacrimal nerve is the smallest of the three branches of the ophthalmic division of the trigeminal nerve.
http://purl.obolibrary.org/obo/UBERON_0011104	epiphysis of fifth metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone		An epiphysis that is part of a metacarpal bone of digit 5.
http://purl.obolibrary.org/obo/UBERON_0011107	synovial joint of pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0008114	joint of girdle		A synovial joint that is part of a pelvic girdle region.
http://purl.obolibrary.org/obo/UBERON_0011108	synovial joint of pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0008114	joint of girdle		A synovial joint that is part of a pectoral girdle region.
http://purl.obolibrary.org/obo/UBERON_0011110	humeroulnar joint	http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint		The humeroulnar joint, is part of the elbow-joint or the Olecron Joint, between the ulna and humerus bones is the simple hinge-joint, which allows for movements of flexion, extension and circumduction. The Humero-Ulnar Joint is the junction of trochlear notch of the ulna and the trochlea of the humerus. Owing to the obliquity of the trochlea of the humerus, this movement does not take place in the antero-posterior plane of the body of the humerus. When the forearm is extended and supinated, the axis of the arm and forearm are not in the same line; the arm forms an obtuse angle with the forearm. During flexion, however, the forearm and the hand tend to approach the middle line of the body, and thus enable the hand to be easily carried to the face. The accurate adaptation of the trochlea of the humerus, with its prominences and depressions, to the semilunar notch of the ulna, prevents any lateral movement. Flexion is produced by the action of the Biceps brachii and Brachialis, assisted by the Brachioradialis, with a tiny contribution from the muscles arising from the medial epicondyle of the humerus. Extension is produced by the Triceps brachii and AnconC&us, with a tiny contribution from the muscles arising from the lateral epicondyle of the humerus, such as the Extensor digitorum communis.
http://purl.obolibrary.org/obo/UBERON_0011111	humeroradial joint	http://purl.obolibrary.org/obo/UBERON_0003839	forelimb joint		A hinge joint between the head of the radius and the capitulum of the humerus.
http://purl.obolibrary.org/obo/UBERON_0011112	tibiofibular joint	http://purl.obolibrary.org/obo/UBERON_0003840	hindlimb joint		A joint that connects the tibia and the fibula.
http://purl.obolibrary.org/obo/UBERON_0011118	tarsometatarsal joint	http://purl.obolibrary.org/obo/UBERON_0001487	pes joint		The tarsometatarsal articulations are arthrodial joints in the pes.
http://purl.obolibrary.org/obo/UBERON_0011119	carpometacarpal joint	http://purl.obolibrary.org/obo/UBERON_0001489	manus joint		The carpometacarpal joints (CMC) are joints in the wrist that articulates the distal row of carpal bones and the proximal bases of the metacarpal bones.
http://purl.obolibrary.org/obo/UBERON_0011120	laryngeal joint	http://purl.obolibrary.org/obo/UBERON_0002217	synovial joint		A skeletal joint that connects a laryngeal cartilage.
http://purl.obolibrary.org/obo/UBERON_0011121	cricothyroid joint	http://purl.obolibrary.org/obo/UBERON_0011120	laryngeal joint		The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the thyroid cartilage.
http://purl.obolibrary.org/obo/UBERON_0011122	cricoarytenoid joint	http://purl.obolibrary.org/obo/UBERON_0011120	laryngeal joint		The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the arytenoid cartilage.
http://purl.obolibrary.org/obo/UBERON_0011131	intermetacarpal joint	http://purl.obolibrary.org/obo/UBERON_0001489	manus joint		A skeletal joint that connects two adjacent metacarpals[FMA,modified].
http://purl.obolibrary.org/obo/UBERON_0011132	intercarpal joint	http://purl.obolibrary.org/obo/UBERON_0001489	manus joint		A skeletal joint that connects two carpal bones.
http://purl.obolibrary.org/obo/UBERON_0011133	intermetatarsal joint	http://purl.obolibrary.org/obo/UBERON_0001487	pes joint		A joint that connects two adjacent metatarsals.
http://purl.obolibrary.org/obo/UBERON_0011134	nonsynovial joint	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis.
http://purl.obolibrary.org/obo/UBERON_0011135	intervertebral cartilage	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		A cartilage element that lies between two successive vertebral centra.
http://purl.obolibrary.org/obo/UBERON_0011136	ligament of vertebral column	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		Ligament that joins successive centra. Important in controlling the stiffness of the vertebral column when it flexes.
http://purl.obolibrary.org/obo/UBERON_0011137	axial skeletal system	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Subdivision of the skeletal system which consists of the axial skeleton plus associated joints.
http://purl.obolibrary.org/obo/UBERON_0011138	postcranial axial skeletal system	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
http://purl.obolibrary.org/obo/UBERON_0011139	synovial limb joint	http://purl.obolibrary.org/obo/UBERON_0003657	limb joint		Any synovial joint that is part of a (free) limb.
http://purl.obolibrary.org/obo/UBERON_0011141	appendicular ossicle	http://purl.obolibrary.org/obo/UBERON_0010911	ossicle		Ossicle that is part of the appendicular skeleton.
http://purl.obolibrary.org/obo/UBERON_0011142	axial ossicle	http://purl.obolibrary.org/obo/UBERON_0010911	ossicle		Ossicle that is part of the axial skeleton.
http://purl.obolibrary.org/obo/UBERON_0011143	upper urinary tract	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Subdivision of urinary system which consists of the kidney and the ureters.
http://purl.obolibrary.org/obo/UBERON_0011145	adductor muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		A muscle capable of adduction. Adduction is a movement which brings a part of the anatomy closer to the middle sagittal plane of the body. It is opposed to abduction.
http://purl.obolibrary.org/obo/UBERON_0011148	submucosal gland	http://purl.obolibrary.org/obo/UBERON_0000414	mucous gland		Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue.
http://purl.obolibrary.org/obo/UBERON_0011151	jaw depressor muscle	http://purl.obolibrary.org/obo/UBERON_0005493	hyoid muscle		A muscle whose action is to depress the lower jaw.
http://purl.obolibrary.org/obo/UBERON_0011156	facial skeleton	http://purl.obolibrary.org/obo/UBERON_0011158	primary subdivision of skull		Subdivision of skull that consists of the facial bones.
http://purl.obolibrary.org/obo/UBERON_0011158	primary subdivision of skull	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		The skull can be divided into two: the neurocranium and the facial skeleton.
http://purl.obolibrary.org/obo/UBERON_0011160	nasal suture	http://purl.obolibrary.org/obo/UBERON_0009199	facial suture		A suture joining a nasal bone to another bone.
http://purl.obolibrary.org/obo/UBERON_0011164	neurocranium bone	http://purl.obolibrary.org/obo/UBERON_0004766	cranial bone		A bone that is part of a neurocranium [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0011171	joint connecting upper and lower jaws	http://purl.obolibrary.org/obo/UBERON_0002217	synovial joint		Synovial joint that articulates bones of upper and lower jaw.
http://purl.obolibrary.org/obo/UBERON_0011184	epithelium of crypt of Lieberkuhn	http://purl.obolibrary.org/obo/UBERON_0001277	intestinal epithelium		An epithelium that is part of a crypt of Lieberkuhn.
http://purl.obolibrary.org/obo/UBERON_0011185	gastrointestinal sphincter	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A sphincter muscle that is part of the gastrointestinal system.
http://purl.obolibrary.org/obo/UBERON_0011189	lamina propria of large intestine	http://purl.obolibrary.org/obo/UBERON_0004780	gastrointestinal system lamina propria		A lamina propria that is part of a large intestine.
http://purl.obolibrary.org/obo/UBERON_0011191	ophthalmic vein	http://purl.obolibrary.org/obo/UBERON_0009141	craniocervical region vein		Ophthalmic veins are veins which drain the eye. More specifically, they can refer to: Superior ophthalmic vein Inferior ophthalmic vein.
http://purl.obolibrary.org/obo/UBERON_0011192	superior ophthalmic vein	http://purl.obolibrary.org/obo/UBERON_0011191	ophthalmic vein		The superior ophthalmic vein begins at the inner angle of the orbit in a vein named the nasofrontal which communicates anteriorly with the angular vein; it pursues the same course as the ophthalmic artery, and receives tributaries corresponding to the branches of that vessel. Forming a short single trunk, it passes between the two heads of the Rectus lateralis and through the medial part of the superior orbital fissure, and ends in the cavernous sinus. The ethmoidal veins drain into the superior ophthalmic vein. Vorticose veins also drain into the superior ophthalmic vein.
http://purl.obolibrary.org/obo/UBERON_0011197	parathyroid epithelium	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An epithelium that is part of a parathyroid gland.
http://purl.obolibrary.org/obo/UBERON_0011198	muscle layer of large intestine	http://purl.obolibrary.org/obo/UBERON_0012367	muscle layer of intestine		A muscle layer that is part of a large intestine.
http://purl.obolibrary.org/obo/UBERON_0011200	sacrococcygeal symphysis	http://purl.obolibrary.org/obo/UBERON_0001468	intervertebral joint		The sacrococcygeal symphysis (sacrococcygeal articulation, articulation of the sacrum and coccyx) is an amphiarthrodial joint, formed between the oval surface at the apex of the sacrum, and the base of the coccyx. It is a slightly moveable joint which is frequently, partially or completely, obliterated in old age, homologous with the joints between the bodies of the vertebrae.
http://purl.obolibrary.org/obo/UBERON_0011201	muscle layer of small intestine	http://purl.obolibrary.org/obo/UBERON_0012367	muscle layer of intestine		A muscle layer that is part of a small intestine.
http://purl.obolibrary.org/obo/UBERON_0011202	urachus epithelium	http://purl.obolibrary.org/obo/UBERON_0006555	excretory tube		An epithelium that is part of a urachus.
http://purl.obolibrary.org/obo/UBERON_0011203	urachus mesenchyme	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		Mesenchyme that is part of a developing urachus.
http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster	http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure		A multi cell part structure that is part of a central nervous system.
http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		A subdivision of an anatomical system.
http://purl.obolibrary.org/obo/UBERON_0011220	mastoid process of temporal bone	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		The mastoid process is a conical prominence projecting from the undersurface of the mastoid portion of the temporal bone. It is located just behind the external acoustic meatus, and lateral to the styloid process. Its size and form vary somewhat; it is larger in the male than in the female. This process serves for the attachment of the posterior belly of the digastric, sternocleidomastoid, splenius capitis, and longissimus capitis muscles. The word is derived from the Greek 'masto-', alluding to its resemblance to the breast.
http://purl.obolibrary.org/obo/UBERON_0011233	synovial membrane of synovial tendon sheath	http://purl.obolibrary.org/obo/UBERON_0007616	layer of synovial tissue		Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa.
http://purl.obolibrary.org/obo/UBERON_0011241	ethmoid region	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		The most anterior region of the braincase. Provides structural support for peripheral olfactory organ.
http://purl.obolibrary.org/obo/UBERON_0011249	appendicular skeletal system	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints.
http://purl.obolibrary.org/obo/UBERON_0011250	autopod bone	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones.
http://purl.obolibrary.org/obo/UBERON_0011265	carpometacarpal joint of digit 1	http://purl.obolibrary.org/obo/UBERON_0011119	carpometacarpal joint		A carpometacarpal joint that connects to metacarpal 1.
http://purl.obolibrary.org/obo/UBERON_0011270	dorsal trunk	http://purl.obolibrary.org/obo/UBERON_0009569	subdivision of trunk		The part of the trunk that is in the dorsum[cjm].
http://purl.obolibrary.org/obo/UBERON_0011273	nail of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0009565	nail of manual digit		A nail that is part of a manual digit 1.
http://purl.obolibrary.org/obo/UBERON_0011274	nail of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0009565	nail of manual digit		A nail that is part of a manual digit 2.
http://purl.obolibrary.org/obo/UBERON_0011275	nail of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0009565	nail of manual digit		A nail that is part of a manual digit 3.
http://purl.obolibrary.org/obo/UBERON_0011276	nail of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0009565	nail of manual digit		A nail that is part of a manual digit 4.
http://purl.obolibrary.org/obo/UBERON_0011277	nail of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0009565	nail of manual digit		A nail that is part of a manual digit 5.
http://purl.obolibrary.org/obo/UBERON_0011278	nail of pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0009567	nail of pedal digit		A nail that is part of a pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0011279	nail of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0009567	nail of pedal digit		A nail that is part of a pedal digit 2.
http://purl.obolibrary.org/obo/UBERON_0011280	nail of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0009567	nail of pedal digit		A nail that is part of a pedal digit 3.
http://purl.obolibrary.org/obo/UBERON_0011281	nail of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0009567	nail of pedal digit		A nail that is part of a pedal digit 4.
http://purl.obolibrary.org/obo/UBERON_0011282	nail of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0009567	nail of pedal digit		A nail that is part of a pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0011289	pharyngobasilar fascia	http://purl.obolibrary.org/obo/UBERON_0006614	aponeurosis		The pharyngeal aponeurosis (or pharyngobasilar fascia, or fibrous coat), is situated between the mucous and muscular layers. It is thick above where the muscular fibers are wanting, and is firmly connected to the basilar portion of the occipital and the petrous portions of the temporal bones. As it descends it diminishes in thickness, and is gradually lost. It is strengthened posteriorly by a strong fibrous band, which is attached above to the pharyngeal spine on the under surface of the basilar portion of the occipital bone, and passes downward, forming a median raphe, which gives attachment to the Constrictores pharyngis.
http://purl.obolibrary.org/obo/UBERON_0011298	submucosa of fallopian tube	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The submucous layer of the wall of the uterine tube.
http://purl.obolibrary.org/obo/UBERON_0011299	white matter of telencephalon	http://purl.obolibrary.org/obo/UBERON_0019261	white matter of forebrain		A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum.
http://purl.obolibrary.org/obo/UBERON_0011300	gray matter of telencephalon	http://purl.obolibrary.org/obo/UBERON_0019264	gray matter of forebrain		A portion of gray matter that is part of a telencephalon.
http://purl.obolibrary.org/obo/UBERON_0011305	superficial part of temporalis	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		The superficial temporalis muscle is a separable part of the temporalis muscle that attaches to the temporalis fascia.
http://purl.obolibrary.org/obo/UBERON_0011306	deep part of temporalis	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		The deep temporalis muscle is a separable part of the temporalis muscle that that attaches to the bony wall of the braincase and is deep to the superficial temporalis.
http://purl.obolibrary.org/obo/UBERON_0011318	capsule of temporomandibular joint	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		The articular capsule (capsular ligament) is a thin, loose envelope, attached above to the circumference of the mandibular fossa and the articular tubercle immediately in front; below, to the neck of the condyle of the mandible.
http://purl.obolibrary.org/obo/UBERON_0011321	masseteric nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A muscular branch of the mandibular nerve passing to the medial surface of the masseter muscle, which it innervates.
http://purl.obolibrary.org/obo/UBERON_0011322	mylohyoid nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that innervates the mylohyoid muscle and the anterior belly of the digastric muscle.
http://purl.obolibrary.org/obo/UBERON_0011342	surface of mandible	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		An anatomical surface that is part of a mandible.
http://purl.obolibrary.org/obo/UBERON_0011349	pterygomandibular raphe	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		The pterygomandibular raphe (pterygomandibular ligament) is a tendinous band of the buccopharyngeal fascia, attached by one extremity to the hamulus of the medial pterygoid plate, and by the other to the posterior end of the mylohyoid line of the mandible. Its medial surface is covered by the mucous membrane of the mouth. Its lateral surface is separated from the ramus of the mandible by a quantity of adipose tissue. Its posterior border gives attachment to the superior pharyngeal constrictor muscle. Its anterior border attaches to the posterior edge of the buccinator.
http://purl.obolibrary.org/obo/UBERON_0011362	cranial blood vasculature	http://purl.obolibrary.org/obo/UBERON_0004537	blood vasculature		A blood vasculature that is part of a head.
http://purl.obolibrary.org/obo/UBERON_0011363	cranial lymph vasculature	http://purl.obolibrary.org/obo/UBERON_0004536	lymph vasculature		A lymph vasculature that is part of a head.
http://purl.obolibrary.org/obo/UBERON_0011364	cleidocephalicus muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		The cleidomastoideus is a thick, strap-like muscle that together with the cleidocervicalis forms the proximal part of the brachiocephalicus. It lies beneath the cleidocervicalis. Its origin is the clavicular tendon with its insertion being at the mastoid process of the temporal bone. It is distinctly narrow and is united with the cleidocervicalis and cleidobrachialis by the clavicular tendon. Together with the other two components of the brachiocephalicus muscle, its primary function is to advance the free limb, however, it can also act as an shoulder extensor. Acting bilaterally, it fixes and depresses the neck, while by its unilateral action, it allows the head and neck to be drawn to the side. Its blood supply is the inferior cervical, carotid and vertebral arteries and its nerve supply is the spinal accessory, cervical and axillary nerves.
http://purl.obolibrary.org/obo/UBERON_0011366	cleidobrachialis muscle	http://purl.obolibrary.org/obo/UBERON_0001482	muscle of shoulder		This muscle makes up the distal segment of the brachiocephalicus. It originates at the clavicular tendon but functionally, from the head and neck through the cleidocervicalis. It inserts at the distal end of the cranial border of the humerus, where it lies between the biceps brachii medially and the brachialis laterally. The muscle partly covers the pectoral muscles at their insertions. In conjunction with the cleidocervicalis, it advances the limb, extends the shoulder and causes lateral movement of the head and neck.
http://purl.obolibrary.org/obo/UBERON_0011368	brachiocephalic muscle	http://purl.obolibrary.org/obo/UBERON_0001482	muscle of shoulder		The brachiocephalicus is a long and flat, complex of muscles that extends from the lower half of the humeral shaft to the head and neck. The muscle divides into two parts at the clavicular intersection. This is also the point of origin for all the muscles that make up the brachiocephalicus. This point is situated just cranial to the shoulder. The two main sections are the cleidobrachialis which is distal to the clavicular intersection and the cleidocephalicus which extends proximally to the clavivular intersection. The cleidocephalicus can also be divided into the pars cervicalis, which inserts on the broad aponeurosis, over the fibrous raphe of the cranial half of the neck. The other part, the pars mastoideus inserts on the mastoid process of the temporal bone via a strong tendon. The cleidobrachialis extends distally from the clavicular intersection and inserts on the cranial edge of the distal half of the humerus. The tendon that inserts the cleidobrachialis lies between the brachialis muscle and the biceps brachii. As a result of the brachiocephalicus spanning a large region it has the ability to provide a number of actions. These include extending the shoulder joint, protracts the limb, provides lateral movement of the head and allows the neck to be depressed.
http://purl.obolibrary.org/obo/UBERON_0011370	transverse process of atlas	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A transverse process of vertebra that is part of a vertebral bone 1.
http://purl.obolibrary.org/obo/UBERON_0011371	sternocephalicus muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		The sternocephalicus is a flat muscle and its caudal border is adjacent to the ventral border of the brachiocephalicus. The lateral aspect of this muscle is crossed obliquely by the external jugular vein. It originates as a unit on the first sternebrae. The cranial portion of the muscle divides into two separate sections with different insertion points. These are the sternomastoideus and the sterno-occipitalis. The ventral portion, the sternomastiodeus is the stronger and main continuation of the sternocephalicus, which inserts on the mastoid part of the temporal bone. The thin but wide dorsal segment, the sterno-occipitalis attaches to the dorsal nuchal crest by a thin aponeurosis. The main action provided by the sternocephalicus is movement of the head and neck to the side. Ventral branches of the cervical nerves are attached to this muscle.
http://purl.obolibrary.org/obo/UBERON_0011375	skin of prepuce of clitoris	http://purl.obolibrary.org/obo/UBERON_0005298	skin of clitoris		A zone of skin that is part of a prepuce of clitoris.
http://purl.obolibrary.org/obo/UBERON_0011379	male external urethral sphincter	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The external sphincter muscle of urethra (or sphincter urethrae membranaceae) surrounds the whole length of the membranous portion of the urethra, and is enclosed in the fasciæ of the urogenital diaphragm. They arch across the front of the urethra and bulbourethral glands, pass around the urethra, and behind it unite with the muscle of the opposite side, by means of a tendinous raphé.
http://purl.obolibrary.org/obo/UBERON_0011380	female external urethral sphincter	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The external sphincter muscle of female urethra is a muscle which controls urination.
http://purl.obolibrary.org/obo/UBERON_0011386	facial modiolus	http://purl.obolibrary.org/obo/UBERON_0002385	muscle tissue		A chiasma of facial muscles held together by fibrous tissue, located lateral and slightly superior to each angle of the mouth. It is important in moving the mouth, facial expression and in dentistry. It derives its motor nerve supply from the facial nerve, and its blood supply from labial branches of the facial artery. It is contributed to by the following muscles: orbicularis oris, buccinator, levator anguli oris, depressor anguli oris, zygomaticus major, risorius quadratus labii superioris, quadratus labii inferioris.
http://purl.obolibrary.org/obo/UBERON_0011390	pudendal nerve	http://purl.obolibrary.org/obo/UBERON_0003444	pelvis nerve		The pudendal nerve is a somatic nerve in the pelvic region that innervates the external genitalia of both sexes, as well as sphincters for the bladder and the rectum. It originates in Onuf's nucleus in the sacral region of the spinal cord.
http://purl.obolibrary.org/obo/UBERON_0011391	perineal nerve	http://purl.obolibrary.org/obo/UBERON_0003444	pelvis nerve		A nerve arising from the pudendal nerve that supplies the perineum.
http://purl.obolibrary.org/obo/UBERON_0011566	lumen of esophagus	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that is part of a esophagus.
http://purl.obolibrary.org/obo/UBERON_0011574	mesonephric duct lumen	http://purl.obolibrary.org/obo/UBERON_0005082	tube lumen		A tube lumen that is part of a mesonephric duct.
http://purl.obolibrary.org/obo/UBERON_0011575	styloid process of ulna	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		The styloid process of the ulna projects from the medial and back part of the bone; it descends a little lower than the head, and its rounded end affords attachment to the ulnar collateral ligament of the wrist[WP,unvetted].
http://purl.obolibrary.org/obo/UBERON_0011576	supraorbital ridge	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The superior half of the orbital rim, which constitutes the curved superior border of the orbital opening, formed by the frontal bone.
http://purl.obolibrary.org/obo/UBERON_0011582	paired limb/fin skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		The collection of all skeletal elements in an individual limb or fin.
http://purl.obolibrary.org/obo/UBERON_0011583	stylopodial skeleton	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified].
http://purl.obolibrary.org/obo/UBERON_0011584	zeugopodial skeleton	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		Section of the forelimb skeleton located between the stylopodium and the autopodium.
http://purl.obolibrary.org/obo/UBERON_0011585	cell condensation	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995).
http://purl.obolibrary.org/obo/UBERON_0011587	pre-dentine	http://purl.obolibrary.org/obo/UBERON_0010365	odontoid tissue		Odontogenic tissue that is collagen-rich and characteristic of vertebrate teeth and tooth-like structures (e.g., odontodes) deposited by preodontoblasts and odontoblasts that are typically excluded from the matrix.
http://purl.obolibrary.org/obo/UBERON_0011588	pre-enamel	http://purl.obolibrary.org/obo/UBERON_0010365	odontoid tissue		Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix.
http://purl.obolibrary.org/obo/UBERON_0011589	non-mineralized cartilage tissue	http://purl.obolibrary.org/obo/UBERON_0002418	cartilage tissue		Cartilage tissue that is not mineralized.
http://purl.obolibrary.org/obo/UBERON_0011590	commissure of diencephalon	http://purl.obolibrary.org/obo/UBERON_0011591	tract of diencephalon		A commissure that is part of a diencephalon.
http://purl.obolibrary.org/obo/UBERON_0011591	tract of diencephalon	http://purl.obolibrary.org/obo/UBERON_0007702	tract of brain		An axon tract that is part of a diencephalon.
http://purl.obolibrary.org/obo/UBERON_0011593	maxillary tooth	http://purl.obolibrary.org/obo/UBERON_0003267	tooth of upper jaw		A tooth that is attached to a maxilla[TAO,modified].
http://purl.obolibrary.org/obo/UBERON_0011594	dentary tooth	http://purl.obolibrary.org/obo/UBERON_0003268	tooth of lower jaw		Tooth that is attached to a dentary/mandible[TAO,modified].
http://purl.obolibrary.org/obo/UBERON_0011595	jaw region	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions.
http://purl.obolibrary.org/obo/UBERON_0011597	bone of upper jaw	http://purl.obolibrary.org/obo/UBERON_0012360	bone of jaw		Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species).
http://purl.obolibrary.org/obo/UBERON_0011601	gingiva of upper jaw	http://purl.obolibrary.org/obo/UBERON_0001828	gingiva		A gingiva that is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0011602	gingiva of lower jaw	http://purl.obolibrary.org/obo/UBERON_0001828	gingiva		A gingiva that is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0011606	hyomandibular bone	http://purl.obolibrary.org/obo/UBERON_0011608	hyomandibular element		Replacement bone that is bilaterally paired and (in teleosts) articulates with the neurocranium dorsally and the opercle posteriorly[TAO,modified].
http://purl.obolibrary.org/obo/UBERON_0011607	hyomandibular cartilage	http://purl.obolibrary.org/obo/UBERON_0011608	hyomandibular element		Cartilage form of the hyomandibular element.
http://purl.obolibrary.org/obo/UBERON_0011608	hyomandibular element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		The upper paired deep bone or cartilage of the hyoid region, sometimes taking part in jaw suspension and which supports the opercle. Dorsally it articulates with the otic capsule at the hyomandibular fossa, ventrally with the quadrate and symplectic. In most Teleostei it has a foramen for the hyomandibular branch of the facial nerve (VII).
http://purl.obolibrary.org/obo/UBERON_0011641	odontogenic mesenchyme of molar	http://purl.obolibrary.org/obo/UBERON_0003856	uncondensed odontogenic mesenchyme		An odontogenic papilla that is part of a molar tooth [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0011642	oral epithelium from ectoderm	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		An epithelium that develops_from a ectoderm and is part of a oral epithelium.
http://purl.obolibrary.org/obo/UBERON_0011645	iliofemoralis muscle	http://purl.obolibrary.org/obo/UBERON_0001325	muscle of pelvis		Limb extensor that runs from ilium to femur.
http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0011677	trunk vertebra	http://purl.obolibrary.org/obo/UBERON_0004451	trunk or cervical vertebra		A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly.
http://purl.obolibrary.org/obo/UBERON_0011678	hindlimb intermedium bone	http://purl.obolibrary.org/obo/UBERON_0011679	proximal tarsal bone		A proximal tarsal bone that articulates with the fibula.
http://purl.obolibrary.org/obo/UBERON_0011679	proximal tarsal bone	http://purl.obolibrary.org/obo/UBERON_0015081	proximal tarsal endochondral element		A tarsal bone that connected_to a hindlimb zeugopod skeleton.
http://purl.obolibrary.org/obo/UBERON_0011695	embryonic cardiovascular system	http://purl.obolibrary.org/obo/UBERON_0004535	cardiovascular system		A cardiovascular system that is part of a conceptus.
http://purl.obolibrary.org/obo/UBERON_0011742	aortic valve leaflet	http://purl.obolibrary.org/obo/UBERON_0011741	cardiac valve leaflet		A cardiac valve leaflet that is part of a aortic valve.
http://purl.obolibrary.org/obo/UBERON_0011745	pulmonary valve leaflets	http://purl.obolibrary.org/obo/UBERON_0011741	cardiac valve leaflet		A cardiac valve leaflet that is part of a pulmonary valve.
http://purl.obolibrary.org/obo/UBERON_0011754	genital swelling	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Paired structures in the embryo that represent the final stage of development of the caudal end of the external genitals before sexual differentiation. In both males and females the two swellings merge: in the female, they become the posterior labial commissure; In the male, they become the scrotum.
http://purl.obolibrary.org/obo/UBERON_0011755	female labial swelling	http://purl.obolibrary.org/obo/UBERON_0011754	genital swelling		A genital swelling that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0011756	male genital swelling	http://purl.obolibrary.org/obo/UBERON_0011754	genital swelling		A genital swelling that is part of a male reproductive organ.
http://purl.obolibrary.org/obo/UBERON_0011769	cartilaginous projection	http://purl.obolibrary.org/obo/UBERON_0004529	anatomical projection		Anatomical projection that is composed of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0011772	lower jaw opening	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is part of a bone of lower jaw.
http://purl.obolibrary.org/obo/UBERON_0011773	upper jaw opening	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is part of a bone of upper jaw.
http://purl.obolibrary.org/obo/UBERON_0011775	vagus nerve nucleus	http://purl.obolibrary.org/obo/UBERON_0009662	hindbrain nucleus		A cranial nerve nucleus that is associated with a vagus nerve.
http://purl.obolibrary.org/obo/UBERON_0011777	nucleus of spinal cord	http://purl.obolibrary.org/obo/UBERON_0000125	neural nucleus		A neural nucleus that is part of the spinal cord.
http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		A nerve that is part of a head.
http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode	http://purl.obolibrary.org/obo/UBERON_0005085	ectodermal placode		Ectodermal placode that does not develop into a component of the nervous system.
http://purl.obolibrary.org/obo/UBERON_0011817	skin appendage placode	http://purl.obolibrary.org/obo/UBERON_0011814	non-neurogenic ectodermal placode		An ectodermal placode that gives rise to any of the cutaneous appendages that protrude from the skin epidermis (heair, feathers, epidermal scales).
http://purl.obolibrary.org/obo/UBERON_0011819	lumen of atrioventricular canal	http://purl.obolibrary.org/obo/UBERON_0005082	tube lumen		A tube lumen that is part of a atrioventricular canal.
http://purl.obolibrary.org/obo/UBERON_0011820	atrioventricular region	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart.
http://purl.obolibrary.org/obo/UBERON_0011821	irregular connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium.
http://purl.obolibrary.org/obo/UBERON_0011822	dense irregular connective tissue	http://purl.obolibrary.org/obo/UBERON_0011823	dense connective tissue		Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.
http://purl.obolibrary.org/obo/UBERON_0011823	dense connective tissue	http://purl.obolibrary.org/obo/UBERON_0002384	connective tissue		Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.
http://purl.obolibrary.org/obo/UBERON_0011825	loose connective tissue	http://purl.obolibrary.org/obo/UBERON_0011821	irregular connective tissue		Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue.
http://purl.obolibrary.org/obo/UBERON_0011827	areolar gland	http://purl.obolibrary.org/obo/UBERON_0001821	sebaceous gland		A sebaceous glands in the areola surrounding the nipple.
http://purl.obolibrary.org/obo/UBERON_0011845	duct of sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0000058	duct		A duct that is part of a sebaceous gland.
http://purl.obolibrary.org/obo/UBERON_0011846	acinus of sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland		An acinus that is part of a sebaceous gland.
http://purl.obolibrary.org/obo/UBERON_0011847	acinus of parotid gland	http://purl.obolibrary.org/obo/UBERON_0013232	serous acinus		An acinus that is part of a parotid gland.
http://purl.obolibrary.org/obo/UBERON_0011850	acinus of salivary gland	http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland		An acinus that is part of a salivary gland.
http://purl.obolibrary.org/obo/UBERON_0011854	acinus of areolar gland	http://purl.obolibrary.org/obo/UBERON_0011856	acinus of lactiferous gland		An acinus that is part of a areolar gland.
http://purl.obolibrary.org/obo/UBERON_0011856	acinus of lactiferous gland	http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland		An acinus that is part of a mammary gland.
http://purl.obolibrary.org/obo/UBERON_0011857	acinus of lacrimal gland	http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland		An acinus that is part of a lacrimal gland.
http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland	http://purl.obolibrary.org/obo/UBERON_0009842	glandular acinus		An acinus that is part of a exocrine gland.
http://purl.obolibrary.org/obo/UBERON_0011859	internal acoustic meatus	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		The internal auditory meatus (also internal acoustic meatus, internal auditory canal, and internal acoustic canal) is a canal in the petrous bone of the temporal bone of the skull that carries nerves from inside the cranium towards the middle and inner ear compartments namely cranial nerve VII and cranial nerve VIII.
http://purl.obolibrary.org/obo/UBERON_0011861	aorta collagen fibril	http://purl.obolibrary.org/obo/UBERON_0011860	collection of collagen fibrils		The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity.
http://purl.obolibrary.org/obo/UBERON_0011862	pulmonary collagen fibril	http://purl.obolibrary.org/obo/UBERON_0011860	collection of collagen fibrils		The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity.
http://purl.obolibrary.org/obo/UBERON_0011863	bone collagen fibril	http://purl.obolibrary.org/obo/UBERON_0011860	collection of collagen fibrils		The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.
http://purl.obolibrary.org/obo/UBERON_0011864	tendon collagen fibril	http://purl.obolibrary.org/obo/UBERON_0011860	collection of collagen fibrils		The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity.
http://purl.obolibrary.org/obo/UBERON_0011865	corneal stroma collagen fibril	http://purl.obolibrary.org/obo/UBERON_0011860	collection of collagen fibrils		The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity.
http://purl.obolibrary.org/obo/UBERON_0011871	nasomaxillary suture	http://purl.obolibrary.org/obo/UBERON_0003685	cranial suture		A cranial suture that connects a nasal bone and connects a maxilla.
http://purl.obolibrary.org/obo/UBERON_0011875	ligament of sternoclavicular joint	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		A skeletal ligament that is part of a sternoclavicular joint.
http://purl.obolibrary.org/obo/UBERON_0011877	margin of tongue	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		The lateral border that separates the dorsum from the inferior surface of the tongue on each side, the two borders meeting anteriorly at the apex..
http://purl.obolibrary.org/obo/UBERON_0011878	muscle layer of esophagus	http://purl.obolibrary.org/obo/UBERON_0018261	muscular coat of digestive tract		A muscle layer that is part of a wall of esophagus.
http://purl.obolibrary.org/obo/UBERON_0011892	anterior uvea	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris.
http://purl.obolibrary.org/obo/UBERON_0011894	lumen of vagina	http://purl.obolibrary.org/obo/UBERON_0002558	organ cavity		An organ cavity that is part of a vagina.
http://purl.obolibrary.org/obo/UBERON_0011899	epimysium	http://purl.obolibrary.org/obo/UBERON_0011822	dense irregular connective tissue		Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous.
http://purl.obolibrary.org/obo/UBERON_0011918	line of Schwalbe	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		The thickened peripheral margin of the vitreous membrane of the cornea.
http://purl.obolibrary.org/obo/UBERON_0011919	yolk sac blood island	http://purl.obolibrary.org/obo/UBERON_0003061	blood island		Masses of developing blood cells attached to endothelium in the yolk sac.
http://purl.obolibrary.org/obo/UBERON_0011922	cochlear basement membrane	http://purl.obolibrary.org/obo/UBERON_0005769	basement membrane of epithelium		The the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes.
http://purl.obolibrary.org/obo/UBERON_0011925	preganglionic autonomic fiber	http://purl.obolibrary.org/obo/UBERON_0003041	trigeminal nerve fibers		Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released.
http://purl.obolibrary.org/obo/UBERON_0011927	preganglionic sympathetic fiber	http://purl.obolibrary.org/obo/UBERON_0011925	preganglionic autonomic fiber		A cholinergic axonal fiber projecting from the CNS to a sympathetic ganglion.
http://purl.obolibrary.org/obo/UBERON_0011930	preganglionic parasympathetic fiber	http://purl.obolibrary.org/obo/UBERON_0011925	preganglionic autonomic fiber		A cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion.
http://purl.obolibrary.org/obo/UBERON_0011931	nasal hair	http://purl.obolibrary.org/obo/UBERON_0010171	strand of hair of face		Hair in the nose.
http://purl.obolibrary.org/obo/UBERON_0011932	pilosebaceous unit	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		An epidermal invagination that has as parts a hair follicle, a sebaceous gland, and arrector pili muscle.
http://purl.obolibrary.org/obo/UBERON_0011953	stomach glandular region	http://purl.obolibrary.org/obo/UBERON_0009870	zone of stomach		A region of the stomach that is lined with glandular epithelium.
http://purl.obolibrary.org/obo/UBERON_0011955	left hepatic vein	http://purl.obolibrary.org/obo/UBERON_0001143	hepatic vein		A hepatic vein that is part of a left lobe of liver.
http://purl.obolibrary.org/obo/UBERON_0011956	right hepatic vein	http://purl.obolibrary.org/obo/UBERON_0001143	hepatic vein		A hepatic vein that is part of a right lobe of liver.
http://purl.obolibrary.org/obo/UBERON_0011960	articular capsule of glenohumeral joint	http://purl.obolibrary.org/obo/UBERON_0001484	articular capsule		An articular capsule that is part of the glenohumeral joint.
http://purl.obolibrary.org/obo/UBERON_0011961	articular capsule of hip joint	http://purl.obolibrary.org/obo/UBERON_0005179	pelvic region element		An articular capsule that is part of the hip joint.
http://purl.obolibrary.org/obo/UBERON_0011962	transverse tarsal joint	http://purl.obolibrary.org/obo/UBERON_0001487	pes joint		The transverse tarsal joint is formed by the articulation of the calcaneus with the cuboid, and the articulation of the talus with the navicular. The movement which takes place in this joint is more extensive than that in the other tarsal joints, and consists of a sort of rotation by means of which the foot may be slightly flexed or extended, the sole being at the same time carried medially (inverted) or laterally.
http://purl.obolibrary.org/obo/UBERON_0011963	talocalcaneonavicular joint	http://purl.obolibrary.org/obo/UBERON_0003698	subtalar joint		The talocalcaneonavicular articulation is an arthrodial joint: the rounded head of the talus being received into the concavity formed by the posterior surface of the navicular, the anterior articular surface of the calcaneus, and the upper surface of the plantar calcaneonavicular ligament. There are two ligaments in this joint: the articular capsule and the dorsal talonavicular.
http://purl.obolibrary.org/obo/UBERON_0011964	calcaneocuboid joint	http://purl.obolibrary.org/obo/UBERON_0011969	mesotarsal joint		Calcaneocuboid Articulation (articulation of the calcaneus with the cuboid). The ligaments connecting the calcaneus with the cuboid are five in number, viz. , the articular capsule, the dorsal calcaneocuboid, part of the bifurcated, the long plantar, and the plantar calcaneocuboid.
http://purl.obolibrary.org/obo/UBERON_0011968	radio-carpal joint	http://purl.obolibrary.org/obo/UBERON_0001491	wrist joint		A skeletal joint that connects a radius bone and connects a carpal skeleton.
http://purl.obolibrary.org/obo/UBERON_0011969	mesotarsal joint	http://purl.obolibrary.org/obo/UBERON_0011980	crurotarsal joint		An ankle joint that passes between the proximal and distal tarsals.
http://purl.obolibrary.org/obo/UBERON_0011970	talofibular ligament	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		A skeletal ligament that connects the fibula to the talus. Examples: anterior and posterior talofibular ligament.
http://purl.obolibrary.org/obo/UBERON_0011971	calcaneofibular ligament	http://purl.obolibrary.org/obo/UBERON_0003701	calcaneal tendon		A skeletal ligament that connects the fibula to the calcaneus.
http://purl.obolibrary.org/obo/UBERON_0011972	medial ligament of ankle joint	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		A skeletal ligament that connects a tibia and connects a tarsal skeleton.
http://purl.obolibrary.org/obo/UBERON_0011973	epiphysis of phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0001437	epiphysis		An epiphysis that is part of a phalanx of a pes [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0011974	epiphysis of proximal phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0011973	epiphysis of phalanx of pes		An epiphysis that is part of a proximal phalanx of pes.
http://purl.obolibrary.org/obo/UBERON_0011975	epiphysis of middle phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0011973	epiphysis of phalanx of pes		An epiphysis that is part of a middle phalanx of pes.
http://purl.obolibrary.org/obo/UBERON_0011976	epiphysis of distal phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0011973	epiphysis of phalanx of pes		An epiphysis that is part of a distal phalanx of pes.
http://purl.obolibrary.org/obo/UBERON_0011977	epiphysis of proximal phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004387	epiphysis of phalanx of manus		An epiphysis that is part of a proximal phalanx of manus.
http://purl.obolibrary.org/obo/UBERON_0011978	epiphysis of middle phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004387	epiphysis of phalanx of manus		An epiphysis that is part of a middle phalanx of manus.
http://purl.obolibrary.org/obo/UBERON_0011979	epiphysis of distal phalanx of manus	http://purl.obolibrary.org/obo/UBERON_0004387	epiphysis of phalanx of manus		An epiphysis that is part of a distal phalanx of manus.
http://purl.obolibrary.org/obo/UBERON_0011980	crurotarsal joint	http://purl.obolibrary.org/obo/UBERON_0001488	ankle joint		A joint that connects the bones of the crus to the proximal tarsal bones.
http://purl.obolibrary.org/obo/UBERON_0011997	coelom	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The aggregate of the coelemic cavity lumen plus the membranes that line the lumen.
http://purl.obolibrary.org/obo/UBERON_0012054	myocoele	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The cavity within a myotome.
http://purl.obolibrary.org/obo/UBERON_0012070	palatal tooth	http://purl.obolibrary.org/obo/UBERON_0003267	tooth of upper jaw		A tooth that is on the roof of the mouth.
http://purl.obolibrary.org/obo/UBERON_0012071	palate bone	http://purl.obolibrary.org/obo/UBERON_0008907	dermal bone		Any bone that is part of a palate.
http://purl.obolibrary.org/obo/UBERON_0012073	tooth of palatine bone	http://purl.obolibrary.org/obo/UBERON_0012070	palatal tooth		A tooth that is attached to a palatine bone.
http://purl.obolibrary.org/obo/UBERON_0012074	bony part of hard palate	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		A subdivision of skeletal system that subdivision_of a hard palate.
http://purl.obolibrary.org/obo/UBERON_0012075	replacement bone	http://purl.obolibrary.org/obo/UBERON_0010522	replacement element		Bone that forms as a replacement of another structural tissue.
http://purl.obolibrary.org/obo/UBERON_0012076	tibiotalar joint	http://purl.obolibrary.org/obo/UBERON_0011980	crurotarsal joint		A skeletal joint that connects a tibia and connects a talus.
http://purl.obolibrary.org/obo/UBERON_0012080	patella cartilage element	http://purl.obolibrary.org/obo/UBERON_0005863	cartilaginous condensation		A cartilaginous condensation that has the potential to develop into a patella.
http://purl.obolibrary.org/obo/UBERON_0012081	patella pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0005866	pre-cartilage condensation		A pre-cartilage condensation that has the potential to develop into a patella.
http://purl.obolibrary.org/obo/UBERON_0012082	bronchial lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical cavity that is part of a bronchus.
http://purl.obolibrary.org/obo/UBERON_0012102	buccal salivary gland	http://purl.obolibrary.org/obo/UBERON_0001044	saliva-secreting gland		A salivary gland that is part of a cheek.
http://purl.obolibrary.org/obo/UBERON_0012111	diastema	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A space or gap between two teeth.
http://purl.obolibrary.org/obo/UBERON_0012126	fibulare	http://purl.obolibrary.org/obo/UBERON_0011679	proximal tarsal bone		One of two elements that constitute the basal row of tarsals. The fibulare constitutes the preaxial element[AAO].
http://purl.obolibrary.org/obo/UBERON_0012128	nose tip	http://purl.obolibrary.org/obo/UBERON_0006983	anatomical point		Outermost point on an external nose or snout.
http://purl.obolibrary.org/obo/UBERON_0012131	centrale	http://purl.obolibrary.org/obo/UBERON_0015067	centrale endochondral element		Endochondral bone located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE].
http://purl.obolibrary.org/obo/UBERON_0012140	digitopodium region	http://purl.obolibrary.org/obo/UBERON_0012139	segment of autopod		A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region.
http://purl.obolibrary.org/obo/UBERON_0012141	manual digitopodium region	http://purl.obolibrary.org/obo/UBERON_0012140	digitopodium region		A digitopodium region that is part of a manus[Obol]. This includes the fingers and metacarpal region, but excludes the carpal region.
http://purl.obolibrary.org/obo/UBERON_0012142	pedal digitopodium region	http://purl.obolibrary.org/obo/UBERON_0012140	digitopodium region		A digitopodium region that is part of a pes[Obol]. This includes the toes and metatarsal region, but excludes the tarsals region.
http://purl.obolibrary.org/obo/UBERON_0012150	skeleton of digitopodium	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton.
http://purl.obolibrary.org/obo/UBERON_0012151	skeleton of manual digitopodium	http://purl.obolibrary.org/obo/UBERON_0012150	skeleton of digitopodium		A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton.
http://purl.obolibrary.org/obo/UBERON_0012152	skeleton of pedal digitopodium	http://purl.obolibrary.org/obo/UBERON_0012150	skeleton of digitopodium		A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton.
http://purl.obolibrary.org/obo/UBERON_0012167	buccal fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		The Buccal fat pad is one of several encapsulated fat masses in the cheek. It is a deep fat pad located on either side of the face between the buccinator muscle and several more superficial muscles. It should not be confused with the malar fat pad, which is directly below the skin of the cheek. It should also not be confused with jowl fat pads. It is implicated in the formation of hollow cheeks and the nasolabial fold, but not in the formation of jowls.
http://purl.obolibrary.org/obo/UBERON_0012168	umbilical cord blood	http://purl.obolibrary.org/obo/UBERON_0013755	arterial blood		Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP].
http://purl.obolibrary.org/obo/UBERON_0012172	stomach primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		A primordium that has the potential to develop into a stomach.
http://purl.obolibrary.org/obo/UBERON_0012177	skin apocrine gland	http://purl.obolibrary.org/obo/UBERON_0019319	exocrine gland of integumental system		An apocrine gland that is part of a skin of body.
http://purl.obolibrary.org/obo/UBERON_0012180	head or neck skin	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is part of a craniocervical region.
http://purl.obolibrary.org/obo/UBERON_0012193	phrenic vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins.
http://purl.obolibrary.org/obo/UBERON_0012197	intercostal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		The intercostal veins are a group of veins which drain the area between the ribs.
http://purl.obolibrary.org/obo/UBERON_0012198	intercostal space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A space in the rib cage between two successive ribs.
http://purl.obolibrary.org/obo/UBERON_0012236	intercostal lymph node	http://purl.obolibrary.org/obo/UBERON_8450004	intercostal element		The intercostal lymph nodes (intercostal glands ) occupy the posterior parts of the intercostal spaces, in relation to the intercostal vessels. They receive the deep lymphatics from the postero-lateral aspect of the chest; some of these vessels are interrupted by small lateral intercostal glands.
http://purl.obolibrary.org/obo/UBERON_0012239	urinary bladder vasculature	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		Network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP].
http://purl.obolibrary.org/obo/UBERON_0012240	urethral meatus	http://purl.obolibrary.org/obo/UBERON_0010418	urethral opening		External opening or orifice of the urethra through which urine and seminal fluid (in males only) leave the body; in males the meatus presents as a vertical slit normally positioned at the tip of glans penis; in females the meatus is located between the clitoris and the vagina in the vulvular vestibule of the female genitalia[MP].
http://purl.obolibrary.org/obo/UBERON_0012241	male urethral meatus	http://purl.obolibrary.org/obo/UBERON_0012240	urethral meatus		A urethral meatus that is part of a male urethra[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0012242	internal urethral orifice	http://purl.obolibrary.org/obo/UBERON_0010418	urethral opening		The usually crescent-shaped opening of the urinary bladder into the urethra, placed at the anteroinferior angle (apex) of the urinary bladder trigone.
http://purl.obolibrary.org/obo/UBERON_0012246	thyroid follicular lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		A follicular lumen is the closed cavity within a follicle of the thyroid gland. It is surrounded by follicular cells and filled with colloid, a concentrated solution of thyroglobulin.
http://purl.obolibrary.org/obo/UBERON_0012247	cervical gland	http://purl.obolibrary.org/obo/UBERON_0002451	endometrial gland		Mucus-secreting glands in the mucosa of the uterine cervix.
http://purl.obolibrary.org/obo/UBERON_0012248	cervical mucosa	http://purl.obolibrary.org/obo/UBERON_0001295	endometrium		Lining of the head of the uterus (cervix); contains large branched glands; does not undergo sloughing.
http://purl.obolibrary.org/obo/UBERON_0012249	ectocervix	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The part of the cervix uteri that protrudes into the vagina and is lined with stratified squamous epithelium.
http://purl.obolibrary.org/obo/UBERON_0012250	cervix glandular epithelium	http://purl.obolibrary.org/obo/UBERON_0006799	glandular epithelium		A glandular epithelium that is part of a uterine cervix.
http://purl.obolibrary.org/obo/UBERON_0012251	ectocervical epithelium	http://purl.obolibrary.org/obo/UBERON_0004801	cervix epithelium		An epithelium that is part of a ectocervix.
http://purl.obolibrary.org/obo/UBERON_0012252	endocervical epithelium	http://purl.obolibrary.org/obo/UBERON_0012250	cervix glandular epithelium		The glandular epithelium that lines the endocervix.
http://purl.obolibrary.org/obo/UBERON_0012253	cervical squamo-columnar junction	http://purl.obolibrary.org/obo/UBERON_0004801	cervix epithelium		Region of cervical epithelium where columnar epithelium of endocervic and the stratified non-keratinising squamous epithelium of the ectocervic meet.
http://purl.obolibrary.org/obo/UBERON_0012254	abdominal aorta artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		An artery that originates from the abdominal aorta.
http://purl.obolibrary.org/obo/UBERON_0012274	columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified].
http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		Epithelium that derives from the mesoderm. [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0012278	gland of nasal mucosa	http://purl.obolibrary.org/obo/UBERON_0036225	respiratory system gland		The nasal glands are the seromucous glands in the respiratory region of the nasal mucous membrane. The three major types of nasal glands are anterior serous glands, seromucous glands, and Bowman glands.
http://purl.obolibrary.org/obo/UBERON_0012282	mammary fat pad	http://purl.obolibrary.org/obo/UBERON_0004180	mammary gland fat		Encapsulated adipose tissue associated with the mammary gland.
http://purl.obolibrary.org/obo/UBERON_0012283	femoral fat pad	http://purl.obolibrary.org/obo/UBERON_0004266	upper leg connective tissue		Encapsulated adipose tissue associated with the femur.
http://purl.obolibrary.org/obo/UBERON_0012288	centroquartal bone	http://purl.obolibrary.org/obo/UBERON_0001447	tarsal bone		A tarsal bone that is formed from the fusion of the central and 4th tarsal bones.
http://purl.obolibrary.org/obo/UBERON_0012289	fused tarsal bones 2 and 3	http://purl.obolibrary.org/obo/UBERON_0010721	distal tarsal bone		A tarsal bone that is formed from the fusion of the 2nd and 3rd tarsal bones.
http://purl.obolibrary.org/obo/UBERON_0012290	fused carpal bones 2 and 3	http://purl.obolibrary.org/obo/UBERON_0001481	distal carpal bone		A carpal bone that is formed from the fusion of the 2nd and 3rd distal carpal bones.
http://purl.obolibrary.org/obo/UBERON_0012291	lateral malleolus of fibula	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		Malleolus is the name for the bony prominence on each side of the ankle.
http://purl.obolibrary.org/obo/UBERON_0012292	embryonic cloacal fold	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly.
http://purl.obolibrary.org/obo/UBERON_0012299	mucosa of urethra	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a urethra.
http://purl.obolibrary.org/obo/UBERON_0012314	embryonic facial prominence	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		One of five swellings formed during the development of the face.
http://purl.obolibrary.org/obo/UBERON_0012317	vagina orifice	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice.
http://purl.obolibrary.org/obo/UBERON_0012318	anterior ethmoidal artery	http://purl.obolibrary.org/obo/UBERON_0005193	ethmoidal artery		The anterior ethmoidal artery, also anterior ethmoid artery is an artery of the head. Once branching from the ophthalmic artery, it accompanies the nasociliary nerve through the anterior ethmoidal canal to supply the anterior and middle ethmoidal cells, frontal sinus, and anterosuperior aspect of the lateral nasal wall[WP].
http://purl.obolibrary.org/obo/UBERON_0012319	posterior ethmoidal artery	http://purl.obolibrary.org/obo/UBERON_0005193	ethmoidal artery		The posterior ethmoidal artery is an artery of the head. It is smaller than the anterior ethmoidal artery, branches off from the ophthalmic artery when it reaches the medial wall of the orbit.
http://purl.obolibrary.org/obo/UBERON_0012320	cervical artery	http://purl.obolibrary.org/obo/UBERON_0003502	neck blood vessel		An artery of the neck.
http://purl.obolibrary.org/obo/UBERON_0012321	deep cervical artery	http://purl.obolibrary.org/obo/UBERON_0012320	cervical artery		The deep cervical artery (Profunda cervicalis) is an artery of the neck.
http://purl.obolibrary.org/obo/UBERON_0012324	transverse cervical artery	http://purl.obolibrary.org/obo/UBERON_0012320	cervical artery		The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery.
http://purl.obolibrary.org/obo/UBERON_0012329	keratinized stratified squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006915	stratified squamous epithelium		Keratinized stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesize and accumulate keratin.
http://purl.obolibrary.org/obo/UBERON_0012330	nasal-associated lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0001962	gut-associated lymphoid tissue		The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals.
http://purl.obolibrary.org/obo/UBERON_0012344	holocrine gland	http://purl.obolibrary.org/obo/UBERON_0002365	exocrine gland		Any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen.
http://purl.obolibrary.org/obo/UBERON_0012351	urachal lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a urachus.
http://purl.obolibrary.org/obo/UBERON_0012354	acropodium region	http://purl.obolibrary.org/obo/UBERON_0012139	segment of autopod		The segment of the autopod that is distal to the metapodial region and consists of the digits.
http://purl.obolibrary.org/obo/UBERON_0012355	manual acropodium region	http://purl.obolibrary.org/obo/UBERON_0012354	acropodium region		The segment of the manus that is distal to the metacarpal region and consists of the manual digits (fingers).
http://purl.obolibrary.org/obo/UBERON_0012356	pedal acropodium region	http://purl.obolibrary.org/obo/UBERON_0012354	acropodium region		The segment of the pes that is distal to the metatarsal region and consists of the pedal digits (toes).
http://purl.obolibrary.org/obo/UBERON_0012357	digitopodium bone	http://purl.obolibrary.org/obo/UBERON_0011250	autopod bone		A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton.
http://purl.obolibrary.org/obo/UBERON_0012358	manual digitopodium bone	http://purl.obolibrary.org/obo/UBERON_0012357	digitopodium bone		A bone that is part of a the manual digitopodium skeleton - i.e. the fingers or the metacarpal skeleton.
http://purl.obolibrary.org/obo/UBERON_0012359	pedal digitopodium bone	http://purl.obolibrary.org/obo/UBERON_0012357	digitopodium bone		A bone that is part of a the pedal digitopodium skeleton - i.e. the toes or the metatarsal skeleton.
http://purl.obolibrary.org/obo/UBERON_0012360	bone of jaw	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A bone element that is part of a jaw region.
http://purl.obolibrary.org/obo/UBERON_0012363	thyroid follicle epithelium	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An epithelium that is part of a thyroid follicle.
http://purl.obolibrary.org/obo/UBERON_0012367	muscle layer of intestine	http://purl.obolibrary.org/obo/UBERON_0018261	muscular coat of digestive tract		A muscle layer that is part of an intestine.
http://purl.obolibrary.org/obo/UBERON_0012373	sympathetic nerve plexus	http://purl.obolibrary.org/obo/UBERON_0001816	autonomic nerve plexus		A nerve plexus that is part of a sympathetic nervous system.
http://purl.obolibrary.org/obo/UBERON_0012375	subserosa	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		A layer of tissue between the muscularis and serosa.
http://purl.obolibrary.org/obo/UBERON_0012377	muscle layer of jejunum	http://purl.obolibrary.org/obo/UBERON_0011201	muscle layer of small intestine		A muscular coat that is part of a jejunum.
http://purl.obolibrary.org/obo/UBERON_0012378	muscle layer of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		A muscular coat that is part of a urinary bladder.
http://purl.obolibrary.org/obo/UBERON_0012418	respiratory system venous smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004696	venous system smooth muscle		A smooth muscle tissue that is part of a respiratory system venous blood vessel.
http://purl.obolibrary.org/obo/UBERON_0012423	layer of microvilli	http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure		A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified].
http://purl.obolibrary.org/obo/UBERON_0012425	striated border microvillus layer	http://purl.obolibrary.org/obo/UBERON_0012423	layer of microvilli		A microvillus layer that is striated and found in the intestine.
http://purl.obolibrary.org/obo/UBERON_0012429	hematopoietic tissue	http://purl.obolibrary.org/obo/UBERON_0034769	lymphomyeloid tissue		Blood-forming tissue, consisting of reticular fibers and cells.
http://purl.obolibrary.org/obo/UBERON_0012430	tunica fibrosa of eyeball	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth.
http://purl.obolibrary.org/obo/UBERON_0012437	epithelial-mesenchymal boundary	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		An anatomical line that adjacent_to a epithelium and adjacent_to a mesenchyme.
http://purl.obolibrary.org/obo/UBERON_0012463	cloacal lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a cloaca.
http://purl.obolibrary.org/obo/UBERON_0012464	cloacal vent	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives.
http://purl.obolibrary.org/obo/UBERON_0012465	lumen of terminal part of digestive tract	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a terminal part of digestive tract.
http://purl.obolibrary.org/obo/UBERON_0012467	enclosed anatomical space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space with no opening to another space or to the exterior.
http://purl.obolibrary.org/obo/UBERON_0012468	anal tooth	http://purl.obolibrary.org/obo/UBERON_0003913	tooth-like structure		Triangular calcified papillae (often five) placed radially around the anus of some Holothuriidae.
http://purl.obolibrary.org/obo/UBERON_0012475	skeleton of pectoral complex	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle.
http://purl.obolibrary.org/obo/UBERON_0012476	skeleton of pelvic complex	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle.
http://purl.obolibrary.org/obo/UBERON_0012477	dorsal part of neck	http://purl.obolibrary.org/obo/UBERON_0005434	cervical region		The posterior region of the neck, including the suboccipital region.
http://purl.obolibrary.org/obo/UBERON_0012478	cloacal gland	http://purl.obolibrary.org/obo/UBERON_0003408	gland of digestive tract		A gland that is part of a cloaca.
http://purl.obolibrary.org/obo/UBERON_0012480	cloacal mucosa	http://purl.obolibrary.org/obo/UBERON_0000344	mucosa		A mucosa that is part of a cloaca [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0012481	cloacal epithelium	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An epithelium that is part of a cloaca.
http://purl.obolibrary.org/obo/UBERON_0012482	submucosa of cloaca	http://purl.obolibrary.org/obo/UBERON_0018257	submucosa of digestive tract		A submucosa that is part of a cloaca [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0012483	serosa of cloaca	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		A serous membrane that is part of a cloaca [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0012486	muscle layer of cloaca	http://purl.obolibrary.org/obo/UBERON_0018261	muscular coat of digestive tract		A muscular coat that is part of a cloaca.
http://purl.obolibrary.org/obo/UBERON_0012487	vaginal sphincter	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A sphincter muscle that is part of a vagina.
http://purl.obolibrary.org/obo/UBERON_0012488	muscle layer of duodenum	http://purl.obolibrary.org/obo/UBERON_0011201	muscle layer of small intestine		A muscular coat that is part of a duodenum.
http://purl.obolibrary.org/obo/UBERON_0012489	muscle layer of colon	http://purl.obolibrary.org/obo/UBERON_0011198	muscle layer of large intestine		A muscular coat that is part of a colon.
http://purl.obolibrary.org/obo/UBERON_0012490	muscle layer of anal canal	http://purl.obolibrary.org/obo/UBERON_0011198	muscle layer of large intestine		A muscular coat that is part of a anal canal.
http://purl.obolibrary.org/obo/UBERON_0012499	serosa of fallopian tube	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A serous membrane that is part of a fallopian tube.
http://purl.obolibrary.org/obo/UBERON_0012504	adventitia of esophagus	http://purl.obolibrary.org/obo/UBERON_0005742	adventitia		An adventitia that is part of a esophagus.
http://purl.obolibrary.org/obo/UBERON_0012615	umbilical smooth muscle	http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue		A smooth muscle tissue that is part of a umbilical cord.
http://purl.obolibrary.org/obo/UBERON_0012650	gastroduodenal junction	http://purl.obolibrary.org/obo/UBERON_1100000	digestive tract junction		An anatomical junction that connects a stomach and connects a duodenum.
http://purl.obolibrary.org/obo/UBERON_0012651	mucosa of gastroduodenal junction	http://purl.obolibrary.org/obo/UBERON_0001199	mucosa of stomach		A mucosa that is part of a gastroduodenal junction.
http://purl.obolibrary.org/obo/UBERON_0013069	popliteal area	http://purl.obolibrary.org/obo/UBERON_0005055	zone of long bone		A depression on the ventral side of the femur, at the knee joint, between the condyles.
http://purl.obolibrary.org/obo/UBERON_0013118	sulcus of brain	http://purl.obolibrary.org/obo/UBERON_0000093	sulcus		A depression or fissure in the surface of the brain. It surrounds the gyri, creating the characteristic appearance of the brain in humans and other large mammals.
http://purl.obolibrary.org/obo/UBERON_0013124	left posterior cardinal vein	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A posterior cardinal vein that is in_the_left_side_of a multicellular organism.
http://purl.obolibrary.org/obo/UBERON_0013126	vein of abdomen	http://purl.obolibrary.org/obo/UBERON_0003497	abdomen blood vessel		A vein that is part of a abdomen.
http://purl.obolibrary.org/obo/UBERON_0013127	pulmonary venous system	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		The part of the venous system that drains the lungs[Kardong].
http://purl.obolibrary.org/obo/UBERON_0013135	interdental plate	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The interdental plate refers to the bone-filled mesial-distal region between the teeth.
http://purl.obolibrary.org/obo/UBERON_0013136	vein of lip	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains a lip.
http://purl.obolibrary.org/obo/UBERON_0013139	ligament of liver	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A nonskeletal ligament that is part of a liver.
http://purl.obolibrary.org/obo/UBERON_0013140	systemic vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		Any vein within the general circulation that transports blood back to the right atrium of the heart.
http://purl.obolibrary.org/obo/UBERON_0013142	soleal vein	http://purl.obolibrary.org/obo/UBERON_0001551	vein of hindlimb zeugopod		A vein that drains the soleus.
http://purl.obolibrary.org/obo/UBERON_0013143	gastrocnemius vein	http://purl.obolibrary.org/obo/UBERON_0001551	vein of hindlimb zeugopod		A vein that drains the gastrocnemius.
http://purl.obolibrary.org/obo/UBERON_0013151	choroidal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		One of two arteries (anterior and posterior choroidal artery) that supply blood to the choroid plexus, optic tract, hippocampus, globus pallidus, and other various brain regions.
http://purl.obolibrary.org/obo/UBERON_0013158	foregut-midgut junction gland	http://purl.obolibrary.org/obo/UBERON_0003408	gland of digestive tract		A gland that is part of a foregut-midgut junction.
http://purl.obolibrary.org/obo/UBERON_0013161	left lateral ventricle	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A telencephalic ventricle that is in_the_left_side_of a telencephalon.
http://purl.obolibrary.org/obo/UBERON_0013162	right lateral ventricle	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A telencephalic ventricle that is in_the_right_side_of a telencephalon.
http://purl.obolibrary.org/obo/UBERON_0013164	molariform tooth	http://purl.obolibrary.org/obo/UBERON_0001091	calcareous tooth		A molar or premolar.
http://purl.obolibrary.org/obo/UBERON_0013167	cricopharyngeal ligament	http://purl.obolibrary.org/obo/UBERON_0001730	extrinsic ligament of larynx		Laryngeal ligament that connects the cricoid cartilage to the pharynx[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0013168	thyroepiglottic ligament	http://purl.obolibrary.org/obo/UBERON_0006325	laryngeal intrinsic ligament		Laryngeal ligament that connects the epiglottis to the thyroid cartilage[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0013170	cricoarytenoid ligament	http://purl.obolibrary.org/obo/UBERON_0001730	extrinsic ligament of larynx		Laryngeal ligament that connects the cricoid and arytenoid cartilages[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0013171	cricothyroid ligament	http://purl.obolibrary.org/obo/UBERON_0001743	ligament of larynx		This attaches the caudal border of the thyroid cartilage to the ventral arch of the cricoid cartilage. Its sheetlike ventral portion is sometimes referred to as the cricothyroid membrane. Being elastic, it 'balances' movement at the hinge-like cricothyroid joint and determines the resting position of the larynx when the muscles are relaxed[MURDOCH]. The cricothyroid ligament is the larger part of the laryngeal membrane, continuing inferiorly as a median or anterior part and twin lateral ligaments. The median cricothyroid ligament is a flat band of white tissue joining the cricoid and thyroid cartilages, while the lateral cricothyroid ligament is also known as the cricothyroid membrane (also called conus elasticus).
http://purl.obolibrary.org/obo/UBERON_0013172	cricotracheal ligament	http://purl.obolibrary.org/obo/UBERON_0001730	extrinsic ligament of larynx		The cricotracheal ligament connects the cricoid cartilage with the first ring of the trachea[WP]. The caudal border of the cricoid cartilage is joined to the first ring of the trachea by this ligament. It is an extrinsic laryngeal ligament. It resembles the fibrous membrane which connects the cartilaginous rings of the trachea to each other.
http://purl.obolibrary.org/obo/UBERON_0013191	ovarian cortex	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles.
http://purl.obolibrary.org/obo/UBERON_0013192	ovarian medulla	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Highly vascular stroma found in the center of the ovary that forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves; this stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter; it does not contain any ovarian follicles.
http://purl.obolibrary.org/obo/UBERON_0013212	anal sac gland secretion	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		A bodily secretion that is produced by a gland of anal sac.
http://purl.obolibrary.org/obo/UBERON_0013228	sweat gland of eyelid	http://purl.obolibrary.org/obo/UBERON_0013229	eyelid gland		Glands of Moll, also known as ciliary glands, are modified apocrine sweat glands that are found on the margin of the eyelid. They are next to the base of the eyelashes, and anterior to the Meibomian glands within the distal eyelid margin. These glands are relatively large and tubular-shaped. The glands of Moll are named after Dutch oculist Jacob Anton Moll (1832-1914). Glands of Moll empty into the adjacent lashes. Glands of Moll and Zeis secrete lipid that adds to the superficial layer of the tear film, retarding evaporation. The glands of Moll are prone to infection and blockage of its duct with sebum and cell debris. Blockage of the gland's duct causes swelling which can manifest itself as a stye.
http://purl.obolibrary.org/obo/UBERON_0013229	eyelid gland	http://purl.obolibrary.org/obo/UBERON_0015152	gland of ocular region		Any gland that is part of an eyelid. This includes sebaceous glands (Zeis gland, tarsal gland) and sweat glands (Moll's gland).
http://purl.obolibrary.org/obo/UBERON_0013231	sebaceous gland of eyelid	http://purl.obolibrary.org/obo/UBERON_0013229	eyelid gland		Any of the sebaceous glands that are in the eyelid. Examples: gland of Zeis (services eyelashes), gland of Meibom (tarsal gland - unconnected to eyelids).
http://purl.obolibrary.org/obo/UBERON_0013232	serous acinus	http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland		The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells.
http://purl.obolibrary.org/obo/UBERON_0013235	ventrum	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A major organism subdivisionthat is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane.
http://purl.obolibrary.org/obo/UBERON_0013239	future glans penis	http://purl.obolibrary.org/obo/UBERON_0013238	future glans		A future glans that is part of a male genital tubercle.
http://purl.obolibrary.org/obo/UBERON_0013240	future glans clitoris	http://purl.obolibrary.org/obo/UBERON_0013238	future glans		A future glans that is part of a female genital tubercle.
http://purl.obolibrary.org/obo/UBERON_0013241	embryonic urethral groove	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The precursor of the urethra.
http://purl.obolibrary.org/obo/UBERON_0013247	male paramesonephric duct	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		An epithelial tube that develops from a Mullerian duct in a male. Later degenerates.
http://purl.obolibrary.org/obo/UBERON_0013279	diaphysis of fibula	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		A diaphysis that is part of a fibula[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0013280	diaphysis of tibia	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		A diaphysis that is part of a tibia.
http://purl.obolibrary.org/obo/UBERON_0013411	cranial cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		Anatomical cavity that is the lumen of the skull and contains the brain.
http://purl.obolibrary.org/obo/UBERON_0013424	anatomical point connecting sagittal and lambdoidal sutures	http://purl.obolibrary.org/obo/UBERON_0006983	anatomical point		The occipital angle is rounded and corresponds with the point of meeting of the sagittal and lambdoidal sutures-a point which is termed the lambda (after the Greek letter of the same name); in the fetus this part of the skull is membranous, and is called the posterior fontanelle.
http://purl.obolibrary.org/obo/UBERON_0013455	spheno-petrosal fissure	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		The sphenopetrosal fissure (or sphenopetrosal suture) is the cranial suture between the sphenoid bone and the petrous portion of the temporal bone. It is in the middle cranial fossa.
http://purl.obolibrary.org/obo/UBERON_0013472	upper esophagus	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		The upper one third of esophagus in which the muscle layer is composed of muscle cells of the striated type.
http://purl.obolibrary.org/obo/UBERON_0013475	gustatory gland	http://purl.obolibrary.org/obo/UBERON_0003409	gland of tongue		A serous salivary gland which resides adjacent to the moats surrounding the circumvallate papillae in the posterior one-third of the tongue, anterior to the terminal sulcus.
http://purl.obolibrary.org/obo/UBERON_0013479	lung endothelium	http://purl.obolibrary.org/obo/UBERON_0004702	respiratory system blood vessel endothelium		A blood vessel endothelium that is part of a lung [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0013481	crypt of Lieberkuhn of ileum	http://purl.obolibrary.org/obo/UBERON_0001241	crypt of Lieberkuhn of small intestine		An intestinal crypt that is located in the ileum.
http://purl.obolibrary.org/obo/UBERON_0013482	crypt of Lieberkuhn of duodenum	http://purl.obolibrary.org/obo/UBERON_0001241	crypt of Lieberkuhn of small intestine		An intestinal crypt that is located in the duodenum.
http://purl.obolibrary.org/obo/UBERON_0013483	crypt of Lieberkuhn of jejunum	http://purl.obolibrary.org/obo/UBERON_0001241	crypt of Lieberkuhn of small intestine		An intestinal crypt that is located in the jejunum.
http://purl.obolibrary.org/obo/UBERON_0013485	crypt of Lieberkuhn of colon	http://purl.obolibrary.org/obo/UBERON_0001984	crypt of Lieberkuhn of large intestine		An intestinal crypt that is located in the colon. The colonic crypts of Lieberkühn are straight and unbranched and lined largely with goblet cells.
http://purl.obolibrary.org/obo/UBERON_0013491	cervical fascia	http://purl.obolibrary.org/obo/UBERON_0008982	fascia		Any fascia tissue that is part of the neck region.
http://purl.obolibrary.org/obo/UBERON_0013493	abdominal fascia	http://purl.obolibrary.org/obo/UBERON_0008982	fascia		A fascia that is part of a abdomen.
http://purl.obolibrary.org/obo/UBERON_0013501	cloacal sphincter	http://purl.obolibrary.org/obo/UBERON_0014783	cloacal muscle		A sphincter muscle that is part of a cloaca.
http://purl.obolibrary.org/obo/UBERON_0013503	caudal vertebra cartilage element	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		A caudal vertebra endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0013504	caudal vertebra pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0018142	caudal vertebra endochondral element		A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0013505	cervical vertebra cartilage element	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		A cervical vertebra endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0013506	cervical vertebra pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015007	cervical vertebra endochondral element		A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0013507	thoracic vertebra cartilage element	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		A thoracic vertebra endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0013508	thoracic vertebra pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015008	thoracic vertebra endochondral element		A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0013509	lumbar vertebra cartilage element	http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage		A lumbar vertebra endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0013510	lumbar vertebra pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015009	lumbar vertebra endochondral element		A lumbar vertebra endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0013514	space surrounding organism	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The space that surrounds an organism.
http://purl.obolibrary.org/obo/UBERON_0013515	subdivision of oviduct	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		A section through the tube or network of tubes that connects the ovaries to the outside of the body.
http://purl.obolibrary.org/obo/UBERON_0013525	stomach lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The anatomical space that is enclosed by a stomach.
http://purl.obolibrary.org/obo/UBERON_0013526	otocyst lumen	http://purl.obolibrary.org/obo/UBERON_0007473	lumen of epithelial sac		An anatomical cavity that is part of a ear vesicle.
http://purl.obolibrary.org/obo/UBERON_0013581	metapodium bone 1	http://purl.obolibrary.org/obo/UBERON_0003821	metapodium bone		A metapodium bone that is part of a digit 1 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0013582	metapodium bone 2	http://purl.obolibrary.org/obo/UBERON_0003821	metapodium bone		A metapodium bone that is part of a digit 2 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0013583	metapodium bone 3	http://purl.obolibrary.org/obo/UBERON_0003821	metapodium bone		A metapodial bone that is associated with digit III.
http://purl.obolibrary.org/obo/UBERON_0013584	metapodium bone 4	http://purl.obolibrary.org/obo/UBERON_0003821	metapodium bone		A metapodium bone that is part of a digit 4 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0013585	metapodium bone 5	http://purl.obolibrary.org/obo/UBERON_0003821	metapodium bone		A metapodium bone that is part of a digit 5 plus metapodial segment.
http://purl.obolibrary.org/obo/UBERON_0013586	fused metapodial bones 3 and 4	http://purl.obolibrary.org/obo/UBERON_0003821	metapodium bone		An element formed from the fusion of metapodium 3 and metapodium 4 (i.e. either metatarsals 3 and 4 or metacarpals 3 and 4).
http://purl.obolibrary.org/obo/UBERON_0013587	fused metacarpal bones 3 and 4	http://purl.obolibrary.org/obo/UBERON_0013586	fused metapodial bones 3 and 4		An element formed from the fusion of metacarpal 3 and metacarpal 4.
http://purl.obolibrary.org/obo/UBERON_0013588	fused metatarsal bones 3 and 4	http://purl.obolibrary.org/obo/UBERON_0013586	fused metapodial bones 3 and 4		An element formed from the fusion of metatarsal 3 and metatarsal 4.
http://purl.obolibrary.org/obo/UBERON_0013617	upper primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018616	primary upper tooth		A primary molar tooth that is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0013619	upper secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018613	secondary upper tooth		A secondary molar tooth that is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0013620	lower primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018617	primary lower tooth		A primary molar tooth that is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0013621	lower secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018614	permanent lower tooth		A secondary molar tooth that is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0013630	short bone	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		Short bones are designated as those bones that are as wide as they are long. Their primary function is to provide support and stability with little to no movement. They are one of five types of bones: long, short, flat, irregular and sesamoid. Examples of these bones include the tarsals in the foot and the carpals in the hand.
http://purl.obolibrary.org/obo/UBERON_0013631	sesamoid element	http://purl.obolibrary.org/obo/UBERON_0010911	ossicle		Ossicle that develops within bands of dense, regular connective tissue (e.g., tendons and ligaments). Sesamoids are generally located proximate to a bony prominence, over which the dense regular connective tissue wraps, and/or a joint or articulation.
http://purl.obolibrary.org/obo/UBERON_0013632	sesamoid cartilage	http://purl.obolibrary.org/obo/UBERON_0013631	sesamoid element		A sesamoid element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0013636	epithelium of intestinal villus	http://purl.obolibrary.org/obo/UBERON_0001902	epithelium of small intestine		An epithelium that is part of a intestinal villus.
http://purl.obolibrary.org/obo/UBERON_0013637	prostate gland lateral lobe	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The prostate gland lobe that is located on the lateral side of the organ.
http://purl.obolibrary.org/obo/UBERON_0013646	buccal nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The buccal nerve (also called the long buccal nerve) is a nerve in the face. It is a branch of the mandibular nerve (which is itself a branch of the trigeminal nerve) and transmits sensory information from skin over the buccal membrane (in general, the cheek) and from the second and third molar teeth.
http://purl.obolibrary.org/obo/UBERON_0013647	lateral pterygoid nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A nerve that innervates the lateral pterygoid muscle.
http://purl.obolibrary.org/obo/UBERON_0013648	masseteric artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The masseteric artery is small and passes laterally through the mandibular notch to the deep surface of the masseter muscle, which it supplies. It anastomoses with the masseteric branches of the external maxillary artery and with the transverse facial artery.
http://purl.obolibrary.org/obo/UBERON_0013649	fused tarsal bones 1 and 2	http://purl.obolibrary.org/obo/UBERON_0010721	distal tarsal bone		A tarsal bone that is formed from the fusion of the 1st and 2nd tarsal bones.
http://purl.obolibrary.org/obo/UBERON_0013678	anatomical line between inner canthi	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		An anatomical line of the face that connects the two inner (medial) canthi of the eye. The length of this line is known as the inter canthal distance.
http://purl.obolibrary.org/obo/UBERON_0013679	inner canthus of right eye	http://purl.obolibrary.org/obo/UBERON_0005611	inner canthus		An inner canthus that is part of a right eye.
http://purl.obolibrary.org/obo/UBERON_0013680	inner canthus of left eye	http://purl.obolibrary.org/obo/UBERON_0005611	inner canthus		An inner canthus that is part of a left eye.
http://purl.obolibrary.org/obo/UBERON_0013683	left dorsal thalamus	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A dorsal thalamus that is in_the_left_side_of a diencephalon.
http://purl.obolibrary.org/obo/UBERON_0013684	right dorsal thalamus	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A dorsal thalamus that is in_the_right_side_of a diencephalon.
http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		Anatomical space that is an opening in a bone of the skull.
http://purl.obolibrary.org/obo/UBERON_0013686	anatomical conduit space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified].
http://purl.obolibrary.org/obo/UBERON_0013687	pericranium	http://purl.obolibrary.org/obo/UBERON_0002515	periosteum		Periosteum that is part of a skull.
http://purl.obolibrary.org/obo/UBERON_0013688	tonsil germinal center	http://purl.obolibrary.org/obo/UBERON_0010754	germinal center		A germinal center that is part of a tonsil.
http://purl.obolibrary.org/obo/UBERON_0013691	buttock	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		A zone of soft tissue located on the posterior of the lateral side of the pelvic region corresponding to the gluteal muscles.
http://purl.obolibrary.org/obo/UBERON_0013694	brain endothelium	http://purl.obolibrary.org/obo/UBERON_0001986	endothelium		Vascular endothelium found in blood vessels of the blood-brain-barrier.
http://purl.obolibrary.org/obo/UBERON_0013695	colon endothelium	http://purl.obolibrary.org/obo/UBERON_0001986	endothelium		Vascular endothelium found in colon blood vessels.
http://purl.obolibrary.org/obo/UBERON_0013696	tonsil epithelium	http://purl.obolibrary.org/obo/UBERON_0003351	pharyngeal epithelium		The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule.
http://purl.obolibrary.org/obo/UBERON_0013697	exocrine pancreas epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelium lining the exocrine pancreas.
http://purl.obolibrary.org/obo/UBERON_0013698	strand of pubic hair	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		A hair in the frontal genital area of adolescent and adult humans, located on and around the sex organs, the crotch, and sometimes at the top of the inside of the thighs, in the pubic region around the pubis bone.
http://purl.obolibrary.org/obo/UBERON_0013699	strand of axillary hair	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		A strand of hair that is part of a axilla.
http://purl.obolibrary.org/obo/UBERON_0013700	axial musculature	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Musculature of the head and neck, spine, and ribs.
http://purl.obolibrary.org/obo/UBERON_0013701	main body axis	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages.
http://purl.obolibrary.org/obo/UBERON_0013702	body proper	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		The region of the organism associated with the visceral organs.
http://purl.obolibrary.org/obo/UBERON_0013703	integumentary projection	http://purl.obolibrary.org/obo/UBERON_0006003	integumentary adnexa		Anatomical projection that is part of the integumentl system.
http://purl.obolibrary.org/obo/UBERON_0013704	notochordal canal	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily.
http://purl.obolibrary.org/obo/UBERON_0013705	fascia of Scarpa	http://purl.obolibrary.org/obo/UBERON_0003427	abdominal fat pad		The deep layer (fascia of Scarpa) is a layer of the anterior abdominal wall.
http://purl.obolibrary.org/obo/UBERON_0013717	superficial inguinal ring	http://purl.obolibrary.org/obo/UBERON_0006674	inguinal ring		The exit of the inguinal canal.
http://purl.obolibrary.org/obo/UBERON_0013718	dartos muscle	http://purl.obolibrary.org/obo/UBERON_0008982	fascia		The dartos fascia is a fat-free layer of smooth muscular fiber outside the external spermatic fascia but below the skin. It is a continuation of Scarpa's Fascia which is a membranous layer of the subcutaneous tissue in the abdominal wall.
http://purl.obolibrary.org/obo/UBERON_0013719	dartos muscle of scrotum	http://purl.obolibrary.org/obo/UBERON_0013718	dartos muscle		A dartos muscle that is part of a male reproductive system.
http://purl.obolibrary.org/obo/UBERON_0013720	dartos muscle of labia majora	http://purl.obolibrary.org/obo/UBERON_0013718	dartos muscle		A dartos muscle that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0013721	deep inguinal ring	http://purl.obolibrary.org/obo/UBERON_0006674	inguinal ring		The entrance to the inguinal canal.
http://purl.obolibrary.org/obo/UBERON_0013727	notochordal fluid	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Fluid contained within the notochordal canal.
http://purl.obolibrary.org/obo/UBERON_0013739	base of crypt of Lieberkuhn	http://purl.obolibrary.org/obo/UBERON_0011184	epithelium of crypt of Lieberkuhn		The basal portion (further from lumen) of an intestinal crypt. Contains multipotent stem cells. Stem cells in the crypts divide to form daughter cells. One daughter cell from each stem cell division is retained as a stem cell. The other becomes committed to differentiate along one of four pathways to become an enterocyte, enteroendocrine cell, goblet cell or Paneth cell.
http://purl.obolibrary.org/obo/UBERON_0013740	wall of crypt of Lieberkuhn	http://purl.obolibrary.org/obo/UBERON_0011184	epithelium of crypt of Lieberkuhn		The lateral parts of an intestinal crypt, continuous distally with the base and proximally with the intestinal villus epithelium.
http://purl.obolibrary.org/obo/UBERON_0013741	base of crypt of Lieberkuhn of large intestine	http://purl.obolibrary.org/obo/UBERON_0013739	base of crypt of Lieberkuhn		A base of crypt of Lieberkuhn that is part of a large intestine.
http://purl.obolibrary.org/obo/UBERON_0013742	wall of crypt of Lieberkuhn of large intestine	http://purl.obolibrary.org/obo/UBERON_0013740	wall of crypt of Lieberkuhn		A wall of crypt of Lieberkuhn that is part of a large intestine.
http://purl.obolibrary.org/obo/UBERON_0013743	base of crypt of Lieberkuhn of small intestine	http://purl.obolibrary.org/obo/UBERON_0013739	base of crypt of Lieberkuhn		The basal portion (further from lumen) of a intestinal crypt that is located in the small intestine.
http://purl.obolibrary.org/obo/UBERON_0013744	wall of crypt of Lieberkuhn of small intestine	http://purl.obolibrary.org/obo/UBERON_0013740	wall of crypt of Lieberkuhn		The lateral parts of an intestinal crypt that is located in the small intestine, continuous distally with the base and proximally with the intestinal villus epithelium.
http://purl.obolibrary.org/obo/UBERON_0013748	ulnar metaphysis	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is part of a ulna.
http://purl.obolibrary.org/obo/UBERON_0013749	metaphysis of humerus	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is part of a metaphysis.
http://purl.obolibrary.org/obo/UBERON_0013750	metaphysis of tibia	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is part of a tibia.
http://purl.obolibrary.org/obo/UBERON_0013751	metaphysis of radius	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is part of a radius bone.
http://purl.obolibrary.org/obo/UBERON_0013752	diaphysis of metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		A diaphysis that is part of a metacarpal bone.
http://purl.obolibrary.org/obo/UBERON_0013753	distal epiphysis of metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004390	epiphysis of metacarpal bone		A distal epiphysis that is part of a metacarpal bone.
http://purl.obolibrary.org/obo/UBERON_0013754	integumentary system layer	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		An organ component layer that is part of a integumental system.
http://purl.obolibrary.org/obo/UBERON_0013755	arterial blood	http://purl.obolibrary.org/obo/UBERON_0000178	blood		A blood that is part of a artery.
http://purl.obolibrary.org/obo/UBERON_0013756	venous blood	http://purl.obolibrary.org/obo/UBERON_0000178	blood		A blood that is part of a vein.
http://purl.obolibrary.org/obo/UBERON_0013757	capillary blood	http://purl.obolibrary.org/obo/UBERON_0000178	blood		A blood that is part of a capillary.
http://purl.obolibrary.org/obo/UBERON_0013758	cervical os	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		One of two openings in the uterine cervix.
http://purl.obolibrary.org/obo/UBERON_0013760	external cervical os	http://purl.obolibrary.org/obo/UBERON_0013758	cervical os		Opening of uterine cervix into the vagina.
http://purl.obolibrary.org/obo/UBERON_0013761	cervical cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		The cavity formed by the walls of the cervix.
http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.
http://purl.obolibrary.org/obo/UBERON_0013766	epicanthal fold	http://purl.obolibrary.org/obo/UBERON_0001457	skin of eyelid		A fold of skin of the upper eyelid that partially covers the inner corner of the eye.
http://purl.obolibrary.org/obo/UBERON_0013767	frontal process of maxilla	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		A plate of bone from the maxilla that that projects upward, medialward, and backward, by the side of the nose, forming part of its lateral boundary[WP,modified].
http://purl.obolibrary.org/obo/UBERON_0013768	great vessel of heart	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart.
http://purl.obolibrary.org/obo/UBERON_0013769	uterine lumen	http://purl.obolibrary.org/obo/UBERON_0002558	organ cavity		An organ cavity that is part of a uterus.
http://purl.obolibrary.org/obo/UBERON_0013771	line connecting laterally paired nipples	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		Line across midline connecting a left and right nipples.
http://purl.obolibrary.org/obo/UBERON_0013772	left nipple	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A nipple that is in_the_left_side_of a body proper.
http://purl.obolibrary.org/obo/UBERON_0013773	right nipple	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A nipple that is in_the_right_side_of a body proper.
http://purl.obolibrary.org/obo/UBERON_0013774	diaphysis of metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004769	diaphysis		A diaphysis that is part of a metatarsal bone.
http://purl.obolibrary.org/obo/UBERON_0013776	skin of palmar/plantar part of autopod	http://purl.obolibrary.org/obo/UBERON_0015790	autopod skin		A zone of skin that is part of a palmar/plantar part of autopod.
http://purl.obolibrary.org/obo/UBERON_0013777	skin of palm of manus	http://purl.obolibrary.org/obo/UBERON_0013776	skin of palmar/plantar part of autopod		A zone of skin that is part of a palmar part of manus.
http://purl.obolibrary.org/obo/UBERON_0013778	skin of sole of pes	http://purl.obolibrary.org/obo/UBERON_0013776	skin of palmar/plantar part of autopod		A zone of skin that is part of a skin of pes.
http://purl.obolibrary.org/obo/UBERON_0014371	future telencephalon	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Embryonic structure that gives rise to the telencephalon.
http://purl.obolibrary.org/obo/UBERON_0014375	intrinsic muscle of manus	http://purl.obolibrary.org/obo/UBERON_0001500	muscle of manus		Any of the intrinsic muscles of the manus (hand).
http://purl.obolibrary.org/obo/UBERON_0014376	thenar muscle	http://purl.obolibrary.org/obo/UBERON_0014375	intrinsic muscle of manus		Any of the muscles of the thenar eminence, a raised fleshy area on the palm of the hand near the base of the thumb.
http://purl.obolibrary.org/obo/UBERON_0014378	intrinsic muscle of pes	http://purl.obolibrary.org/obo/UBERON_0001498	muscle of pes		Any of the intrinsic muscles of the pes (foot).
http://purl.obolibrary.org/obo/UBERON_0014381	whorl of hair	http://purl.obolibrary.org/obo/UBERON_0010164	collection of hairs		A patch of hair growing in the opposite direction of the rest of the hair.
http://purl.obolibrary.org/obo/UBERON_0014382	collection of hairs on head or neck	http://purl.obolibrary.org/obo/UBERON_0010164	collection of hairs		A collection of hairs that is part of a craniocervical region.
http://purl.obolibrary.org/obo/UBERON_0014386	vertebral endplate	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		Either of the the top and bottom portions of the vertebral bodies that interface with the vertebral discs. It is composed of a layer of thickened cancellous bone.
http://purl.obolibrary.org/obo/UBERON_0014387	mesenchyme derived from neural crest	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		Mesenchyme that develops_from the neural crest[Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014388	kidney collecting duct epithelium	http://purl.obolibrary.org/obo/UBERON_0004211	nephron epithelium		The simple cuboidal epithelium lining the lumen of kidney collecting ducts.
http://purl.obolibrary.org/obo/UBERON_0014389	gustatory papilla of tongue	http://purl.obolibrary.org/obo/UBERON_0001726	papilla of tongue		A papilla that contain taste buds, including the fungiform, foliate, and circumvallate papillae.
http://purl.obolibrary.org/obo/UBERON_0014390	muscle layer of ileum	http://purl.obolibrary.org/obo/UBERON_0011201	muscle layer of small intestine		A muscular coat that is part of a ileum.
http://purl.obolibrary.org/obo/UBERON_0014391	palmar/plantar sweat gland	http://purl.obolibrary.org/obo/UBERON_0000423	eccrine sweat gland		A sweat gland that is part of the skin of the palmar part of the manus or plantar part of the pes.
http://purl.obolibrary.org/obo/UBERON_0014392	sweat of palm	http://purl.obolibrary.org/obo/UBERON_0001089	sweat		Sweat that is produced by the glands on the palmar and plantar surfaces.
http://purl.obolibrary.org/obo/UBERON_0014393	sweat of axilla	http://purl.obolibrary.org/obo/UBERON_0001089	sweat		Sweat that is produced by the glands of the axilla.
http://purl.obolibrary.org/obo/UBERON_0014394	uterine fat pad	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Encapsulated adipose tissue associated with the uterus.
http://purl.obolibrary.org/obo/UBERON_0014395	proximal mesopodial bone	http://purl.obolibrary.org/obo/UBERON_0017750	proximal mesopodial endochondral element		A proximal mesopodial endochondral element that is composed primarily of a bone tissue.
http://purl.obolibrary.org/obo/UBERON_0014398	respiratory muscle	http://purl.obolibrary.org/obo/UBERON_0003831	respiratory system muscle		Muscle that is part of the respiratory system.
http://purl.obolibrary.org/obo/UBERON_0014399	sinusoidal space	http://purl.obolibrary.org/obo/UBERON_0010161	lumen of blood vessel		An anatomical space that is enclosed by a sinusoid.
http://purl.obolibrary.org/obo/UBERON_0014400	hepatic sinusoidal space	http://purl.obolibrary.org/obo/UBERON_0014399	sinusoidal space		A sinusoidal space that is part of a hepatic sinusoid.
http://purl.obolibrary.org/obo/UBERON_0014401	renal venous blood vessel	http://purl.obolibrary.org/obo/UBERON_0003920	venous blood vessel		Any member of the network of tubes that return blood from the renal tissues to the systemic circulation.
http://purl.obolibrary.org/obo/UBERON_0014402	sex-specific anatomical structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A part of the body present only in a specific gender.
http://purl.obolibrary.org/obo/UBERON_0014403	male anatomical structure	http://purl.obolibrary.org/obo/UBERON_0014402	sex-specific anatomical structure		A part of the body present only in males.
http://purl.obolibrary.org/obo/UBERON_0014404	female anatomical structure	http://purl.obolibrary.org/obo/UBERON_0014402	sex-specific anatomical structure		A part of the body present only in females.
http://purl.obolibrary.org/obo/UBERON_0014411	greater sciatic notch	http://purl.obolibrary.org/obo/UBERON_0014430	sciatic notch		On the dorsal border of the wing of the ilium , at it's junction with the shaft is a cut away. This forms the Greater sciatic notch. The sciatic nerve runs over the notch in passage to the hindlimb.
http://purl.obolibrary.org/obo/UBERON_0014430	sciatic notch	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		Either of two notches on the dorsal border of the hip bone on each side that when closed off by ligaments form the corresponding sciatic foramina.
http://purl.obolibrary.org/obo/UBERON_0014437	iliac crest	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		Is part of the pelvis on the edge of the wing of the ilium. Round in shape, dorsal to the pubis and ischium. Acts as structrure that muscles can attach too.
http://purl.obolibrary.org/obo/UBERON_0014438	superior pubic ramus	http://purl.obolibrary.org/obo/UBERON_0014444	pubic ramus		The superior pubic ramus is a part of the pubic bone which forms a portion of the obturator foramen. It extends from the body to the median plane where it articulates with its fellow of the opposite side. It is conveniently described in two portions, viz. , a medial flattened part and a narrow lateral prismoid portion.
http://purl.obolibrary.org/obo/UBERON_0014439	inferior pubic ramus	http://purl.obolibrary.org/obo/UBERON_0014444	pubic ramus		The inferior pubic ramus is thin and flattened. It passes lateralward and downward from the medial end of the superior ramus; it becomes narrower as it descends and joins with the inferior ramus of the ischium below the obturator foramen.
http://purl.obolibrary.org/obo/UBERON_0014445	acetabular fossa	http://purl.obolibrary.org/obo/UBERON_0004704	bone fossa		The acetabular fossa is the roughened depression in the centre of the acetabulum, surrounded by the lunate acetabular surface and the acetabular notch. The acetabular fossa provides an insertion point for the teres ligaments that secure the femoral head.
http://purl.obolibrary.org/obo/UBERON_0014446	acetabular notch	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		The acetabulum presents below a deep notch, the acetabular notch, which is continuous with a circular non-articular depression, the acetabular fossa, at the bottom of the cavity: this depression is perforated by numerous apertures, and lodges a mass of fat. The notch is converted into a foramen by the transverse ligament; through the foramen nutrient vessels and nerves enter the joint; the margins of the notch serve for the attachment of the ligament of the head of the femur.
http://purl.obolibrary.org/obo/UBERON_0014451	tongue taste bud	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A taste bud that is located on the tongue, situated on a gustatory papilla.
http://purl.obolibrary.org/obo/UBERON_0014452	gustatory epithelium of tongue	http://purl.obolibrary.org/obo/UBERON_0003357	epithelium of tongue		A gustatory epithelium that is part of a tongue.
http://purl.obolibrary.org/obo/UBERON_0014453	gustatory epithelium of palate	http://purl.obolibrary.org/obo/UBERON_0002926	gustatory epithelium		A gustatory epithelium that is part of a roof of mouth.
http://purl.obolibrary.org/obo/UBERON_0014454	visceral abdominal adipose tissue	http://purl.obolibrary.org/obo/UBERON_0007808	adipose tissue of abdominal region		Subcutaneous adipose tissue that is located in the peritoneal cavity.
http://purl.obolibrary.org/obo/UBERON_0014455	subcutaneous abdominal adipose tissue	http://purl.obolibrary.org/obo/UBERON_0007808	adipose tissue of abdominal region		Subcutaneous adipose tissue that is located in the abdominal region.
http://purl.obolibrary.org/obo/UBERON_0014463	cardiac ganglion	http://purl.obolibrary.org/obo/UBERON_0001808	parasympathetic ganglion		Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery.
http://purl.obolibrary.org/obo/UBERON_0014464	renal fat pad	http://purl.obolibrary.org/obo/UBERON_0003427	abdominal fat pad		Encapsulated adipose tissue associated with the kidney.
http://purl.obolibrary.org/obo/UBERON_0014477	thoracic skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum.
http://purl.obolibrary.org/obo/UBERON_0014478	rib skeletal system	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		Subdivision of skeletal system that consists of all ribs and rib joints in an organism. In many vertebrates this consists of the combination of the rib cage and all rib joints, but some vertebrates have ribs outside the thoracic rib cage.
http://purl.obolibrary.org/obo/UBERON_0014483	distal phalanx of digit 1	http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx		A distal phalanx that is part of a digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014484	distal phalanx of digit 2	http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx		A distal phalanx that is part of a digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014485	distal phalanx of digit 3	http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx		A distal phalanx that is part of a digit 3. In odd-toes ungulates (Perissodactyla e.g. horses) this is called the coffin bone. In even-toed ungulates (Artiodactyla e.g cattle) this is associated with the medial claw.
http://purl.obolibrary.org/obo/UBERON_0014486	distal phalanx of digit 4	http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx		A distal phalanx that is part of a digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014487	distal phalanx of digit 5	http://purl.obolibrary.org/obo/UBERON_0004300	distal phalanx		A distal phalanx that is part of a digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014488	middle phalanx of digit 2	http://purl.obolibrary.org/obo/UBERON_0004301	middle phalanx		A middle phalanx that is part of a digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014489	middle phalanx of digit 3	http://purl.obolibrary.org/obo/UBERON_0004301	middle phalanx		A middle phalanx that is part of a digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014490	middle phalanx of digit 4	http://purl.obolibrary.org/obo/UBERON_0004301	middle phalanx		A middle phalanx that is part of a digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014491	middle phalanx of digit 5	http://purl.obolibrary.org/obo/UBERON_0004301	middle phalanx		A middle phalanx that is part of a digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014501	proximal phalanx of digit 1	http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx		A proximal phalanx that is part of a autopod digit 1 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014502	proximal phalanx of digit 2	http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx		A proximal phalanx that is part of a autopod digit 2 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014503	proximal phalanx of digit 3	http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx		A proximal phalanx that is part of a autopod digit 3 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014504	proximal phalanx of digit 4	http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx		A proximal phalanx that is part of a autopod digit 4 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014505	proximal phalanx of digit 5	http://purl.obolibrary.org/obo/UBERON_0004302	proximal phalanx		A proximal phalanx that is part of a autopod digit 5 [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014506	distal interphalangeal joint of digit 3	http://purl.obolibrary.org/obo/UBERON_0009768	distal interphalangeal joint		A distal inter-phalangeal joint that is part of the 3rd digit.
http://purl.obolibrary.org/obo/UBERON_0014507	distal interphalangeal joint of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0014506	distal interphalangeal joint of digit 3		A distal inter-phalangeal joint that is part of the 3rd pedal digit.
http://purl.obolibrary.org/obo/UBERON_0014508	distal interphalangeal joint of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0014506	distal interphalangeal joint of digit 3		A distal inter-phalangeal joint that is part of the 3rd manual digit.
http://purl.obolibrary.org/obo/UBERON_0014538	subdivision of spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		A subdivision of the central canal of the spinal cord along its anterior-posterior axis. This is typically subdivided into cervical, thoracic, lumbar and sacral segments.
http://purl.obolibrary.org/obo/UBERON_0014540	white matter lamina of cerebellum	http://purl.obolibrary.org/obo/UBERON_0014530	white matter lamina of neuraxis		The white laminae of cerebellum is subdivision of the cerebellar cortex comprised of myelinated axons lying deep to the granule cell layer of the cerebellar cortex.
http://purl.obolibrary.org/obo/UBERON_0014541	thoracic division of spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014538	subdivision of spinal cord central canal		Part of spinal cord central canal contained in the thoracic spinal cord. It is continuous rostrally with the cervical spinal cord central canal and caudally with the lumbar spinal cord central canal.
http://purl.obolibrary.org/obo/UBERON_0014542	cervical division of cord spinal central canal	http://purl.obolibrary.org/obo/UBERON_0014538	subdivision of spinal cord central canal		Part of central canal contained within the cervical spinal cord. It is continuous caudally with the thoracic spinal cord central canal and rostrally with the fourth ventricle of the brain via the obex.
http://purl.obolibrary.org/obo/UBERON_0014543	lumbar division of spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014538	subdivision of spinal cord central canal		Part of central canal lying within the lumbar spinal cord. It is continuous rostrally with the central canal of the thoracic spinal cord and caudally with the central canal of the sacral spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014547	sacral division of spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014538	subdivision of spinal cord central canal		Part of spinal cord central canal contained in the sacral spinal cord. It is continuous rostrally with the spinal cord central canal of the lumbar cord.
http://purl.obolibrary.org/obo/UBERON_0014610	thoracic spinal cord ventral horn	http://purl.obolibrary.org/obo/UBERON_0002257	ventral horn of spinal cord		A ventral horn of spinal cord that is part of a thoracic spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014613	cervical spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0002315	gray matter of spinal cord		A gray matter of spinal cord that is part of a cervical spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014614	cervical spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0002318	white matter of spinal cord		A white matter of spinal cord that is part of a cervical spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014621	cervical spinal cord ventral horn	http://purl.obolibrary.org/obo/UBERON_0002257	ventral horn of spinal cord		A ventral horn of spinal cord that is part of a cervical spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014636	thoracic spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0002315	gray matter of spinal cord		A gray matter of spinal cord that is part of a thoracic spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014637	thoracic spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0002318	white matter of spinal cord		A white matter of spinal cord that is part of a thoracic spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014639	frontal sulcus	http://purl.obolibrary.org/obo/UBERON_0013118	sulcus of brain		A sulcus of brain that is part of a frontal cortex.
http://purl.obolibrary.org/obo/UBERON_0014649	white matter of medulla oblongata	http://purl.obolibrary.org/obo/UBERON_0019262	white matter of myelencephalon		A white matter that is part of a medulla oblongata.
http://purl.obolibrary.org/obo/UBERON_0014677	distal interphalangeal joint of digit 2	http://purl.obolibrary.org/obo/UBERON_0009768	distal interphalangeal joint		A distal interphalangeal joint that is part of a digit 2.
http://purl.obolibrary.org/obo/UBERON_0014679	distal interphalangeal joint of digit 4	http://purl.obolibrary.org/obo/UBERON_0009768	distal interphalangeal joint		A distal interphalangeal joint that is part of a digit 4.
http://purl.obolibrary.org/obo/UBERON_0014680	distal interphalangeal joint of digit 5	http://purl.obolibrary.org/obo/UBERON_0009768	distal interphalangeal joint		A distal interphalangeal joint that is part of a digit 5.
http://purl.obolibrary.org/obo/UBERON_0014686	angular vein	http://purl.obolibrary.org/obo/UBERON_0009141	craniocervical region vein		The angular vein formed by the junction of the frontal vein and supraorbital vein, runs obliquely downward, on the side of the root of the nose, to the level of the lower margin of the orbit, where it becomes the anterior facial vein. It receives the external nasal veins of the ala nasi, and communicates with the superior ophthalmic vein through the nasofrontal vein, thus establishing an important anastomosis between the anterior facial vein and the cavernous sinus.
http://purl.obolibrary.org/obo/UBERON_0014687	temporal sulcus	http://purl.obolibrary.org/obo/UBERON_0013118	sulcus of brain		Any of three grooves in the temporal lobe including the inferior, middle, and superior temporal sulci.
http://purl.obolibrary.org/obo/UBERON_0014695	deep auricular artery	http://purl.obolibrary.org/obo/UBERON_0009655	auricular artery		The deep auricular artery often arises in common with the anterior tympanic artery. It ascends in the substance of the parotid gland, behind the temporomandibular articulation, pierces the cartilaginous or bony wall of the external acoustic meatus, and supplies its cuticular lining and the outer surface of the tympanic membrane. It gives a branch to the temporomandibular joint.
http://purl.obolibrary.org/obo/UBERON_0014699	extraembryonic venous system	http://purl.obolibrary.org/obo/UBERON_0014701	extraembryonic vascular system		A venous system that overlaps a umbilical cord and is part of a entire extraembryonic component.
http://purl.obolibrary.org/obo/UBERON_0014701	extraembryonic vascular system	http://purl.obolibrary.org/obo/UBERON_0007798	vascular system		A vascular system that overlaps a umbilical cord and is part of a entire extraembryonic component.
http://purl.obolibrary.org/obo/UBERON_0014702	frontonasal process epithelium	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		An epithelium that is part of a frontonasal prominence.
http://purl.obolibrary.org/obo/UBERON_0014703	anal membrane ectodermal component	http://purl.obolibrary.org/obo/UBERON_0010371	ecto-epithelium		A unilaminar epithelium that develops_from a ectoderm and is part of a anal region.
http://purl.obolibrary.org/obo/UBERON_0014704	pleuroperitoneal canal lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a pleuroperitoneal canal.
http://purl.obolibrary.org/obo/UBERON_0014705	median lingual swelling epithelium	http://purl.obolibrary.org/obo/UBERON_0005911	endo-epithelium		An epithelium that is part of a median lingual swelling.
http://purl.obolibrary.org/obo/UBERON_0014716	interlobular duct	http://purl.obolibrary.org/obo/UBERON_0035050	excretory duct		A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory.
http://purl.obolibrary.org/obo/UBERON_0014717	mucous acinus	http://purl.obolibrary.org/obo/UBERON_0011858	acinus of exocrine gland		The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells.
http://purl.obolibrary.org/obo/UBERON_0014719	intralobular duct	http://purl.obolibrary.org/obo/UBERON_0000058	duct		A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular.
http://purl.obolibrary.org/obo/UBERON_0014720	interlobar duct	http://purl.obolibrary.org/obo/UBERON_0035050	excretory duct		A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory.
http://purl.obolibrary.org/obo/UBERON_0014762	fused metapodial bones 2-4	http://purl.obolibrary.org/obo/UBERON_0013586	fused metapodial bones 3 and 4		An element formed from the fusion of metapodium bones 2, 3 and 4 (i.e. either metatarsals 2-4 or metacarpals 3-4).
http://purl.obolibrary.org/obo/UBERON_0014763	fused metatarsal bones 2-4	http://purl.obolibrary.org/obo/UBERON_0014762	fused metapodial bones 2-4		An element formed from the fusion of metapodium bones 2, 3 and 4 in the pedal autopod.
http://purl.obolibrary.org/obo/UBERON_0014764	anatomical line along groove	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		Anatomical line that delineates a furrow or depression in an organ or tissue.
http://purl.obolibrary.org/obo/UBERON_0014768	superior palpebral vein	http://purl.obolibrary.org/obo/UBERON_0014769	palpebral vein		A blood vessel that drains from from an upper eyelid.
http://purl.obolibrary.org/obo/UBERON_0014769	palpebral vein	http://purl.obolibrary.org/obo/UBERON_0009141	craniocervical region vein		A blood vessel that drains from from an eyelid.
http://purl.obolibrary.org/obo/UBERON_0014770	palpebral artery	http://purl.obolibrary.org/obo/UBERON_0003496	head blood vessel		An artery that supplies blood to an eyelid.
http://purl.obolibrary.org/obo/UBERON_0014775	prosomere	http://purl.obolibrary.org/obo/UBERON_0004731	neuromere		A neuromere that is part of the presumptive forebrain.
http://purl.obolibrary.org/obo/UBERON_0014776	midbrain neuromere	http://purl.obolibrary.org/obo/UBERON_0004731	neuromere		A neuromere that is part of the presumptive midbrain.
http://purl.obolibrary.org/obo/UBERON_0014777	spinal neuromere	http://purl.obolibrary.org/obo/UBERON_0004731	neuromere		A neuromere that is part of the presumptive spinal cord.
http://purl.obolibrary.org/obo/UBERON_0014780	palatine aponeurosis	http://purl.obolibrary.org/obo/UBERON_0006614	aponeurosis		Attached to the posterior border of the hard palate is a thin, firm fibrous lamella called the palatine aponeurosis, which supports the muscles and gives strength to the soft palate. It is thicker above than below, where it becomes very thin and difficult to define. Laterally it is continuous with the pharyngeal aponeurosis. It serves as the insertion for the Tensor veli palatini and Levator veli palatini, and the origin for the Musculus uvulae, Palatopharyngeus, and Palatoglossus. It provides support for the soft palate.
http://purl.obolibrary.org/obo/UBERON_0014783	cloacal muscle	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		Any muscle organ that is part of a cloaca.
http://purl.obolibrary.org/obo/UBERON_0014790	lingual septum	http://purl.obolibrary.org/obo/UBERON_0003037	septum		The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ.
http://purl.obolibrary.org/obo/UBERON_0014791	musculature of forelimb stylopod	http://purl.obolibrary.org/obo/UBERON_0004474	musculature of arm		Any collection of muscles that is part of the forelimb stylopod region [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014792	musculature of pelvic complex	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin.
http://purl.obolibrary.org/obo/UBERON_0014793	musculature of pectoral complex	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin.
http://purl.obolibrary.org/obo/UBERON_0014794	pectoral appendage muscle	http://purl.obolibrary.org/obo/UBERON_0010891	pectoral complex muscle		Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin).
http://purl.obolibrary.org/obo/UBERON_0014795	pelvic appendage muscle	http://purl.obolibrary.org/obo/UBERON_0010890	pelvic complex muscle		Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin).
http://purl.obolibrary.org/obo/UBERON_0014796	common tendinous ring	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		A ring of fibrous tissue surrounding the optic nerve at its entrance at the apex of the orbit.
http://purl.obolibrary.org/obo/UBERON_0014847	vastus intermedius	http://purl.obolibrary.org/obo/UBERON_0001377	quadriceps femoris		The Vastus intermedius (Cruraeus) arises from the front and lateral surfaces of the body of the femur in its upper two-thirds, sitting under Rectus Femoris and from the lower part of the lateral intermuscular septum. Its fibers end in a superficial aponeurosis, which forms the deep part of the Quadriceps femoris tendon. The Vastus medialis and Vastus intermedius appear to be inseparably united, but when the Rectus femoris has been reflected a narrow interval will be observed extending upward from the medial border of the patella between the two muscles, and the separation may be continued as far as the lower part of the intertrochanteric line, where, however, the two muscles are frequently continuous.
http://purl.obolibrary.org/obo/UBERON_0014851	chorda tendinea of left ventricle	http://purl.obolibrary.org/obo/UBERON_0005994	chorda tendineae		Chorda tendinea which is attached to the leaflet of mitral valve and is continuous with the endocardium of papillary muscle of left ventricle.
http://purl.obolibrary.org/obo/UBERON_0014852	chorda tendinea of right ventricle	http://purl.obolibrary.org/obo/UBERON_0005994	chorda tendineae		Chorda tendinea which is attached to the leaflet of tricuspid valve and is continuous with the endocardium of papillary muscle of right ventricle.
http://purl.obolibrary.org/obo/UBERON_0014871	distal epiphysis of distal phalanx of pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0014876	distal epiphysis of distal phalanx of pedal digit		A distal epiphysis that is part of a distal phalanx of pedal digit 1.
http://purl.obolibrary.org/obo/UBERON_0014872	distal epiphysis of distal phalanx of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0014876	distal epiphysis of distal phalanx of pedal digit		A distal epiphysis that is part of a distal phalanx of pedal digit 2.
http://purl.obolibrary.org/obo/UBERON_0014873	distal epiphysis of distal phalanx of pedal digit 3	http://purl.obolibrary.org/obo/UBERON_0014876	distal epiphysis of distal phalanx of pedal digit		A distal epiphysis that is part of a distal phalanx of pedal digit 3.
http://purl.obolibrary.org/obo/UBERON_0014874	distal epiphysis of distal phalanx of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0014876	distal epiphysis of distal phalanx of pedal digit		A distal epiphysis that is part of a distal phalanx of pedal digit 4.
http://purl.obolibrary.org/obo/UBERON_0014875	distal epiphysis of distal phalanx of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0014876	distal epiphysis of distal phalanx of pedal digit		A distal epiphysis that is part of a distal phalanx of pedal digit 5.
http://purl.obolibrary.org/obo/UBERON_0014881	distal epiphysis of distal phalanx of manual digit 1	http://purl.obolibrary.org/obo/UBERON_0014886	distal epiphysis of distal phalanx of manual digit		A distal epiphysis that is part of a distal phalanx of manual digit 1.
http://purl.obolibrary.org/obo/UBERON_0014882	distal epiphysis of distal phalanx of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0014886	distal epiphysis of distal phalanx of manual digit		A distal epiphysis that is part of a distal phalanx of manual digit 2.
http://purl.obolibrary.org/obo/UBERON_0014883	distal epiphysis of distal phalanx of manual digit 3	http://purl.obolibrary.org/obo/UBERON_0014886	distal epiphysis of distal phalanx of manual digit		A distal epiphysis that is part of a distal phalanx of manual digit 3.
http://purl.obolibrary.org/obo/UBERON_0014884	distal epiphysis of distal phalanx of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0014886	distal epiphysis of distal phalanx of manual digit		A distal epiphysis that is part of a distal phalanx of manual digit 4.
http://purl.obolibrary.org/obo/UBERON_0014885	distal epiphysis of distal phalanx of manual digit 5	http://purl.obolibrary.org/obo/UBERON_0014886	distal epiphysis of distal phalanx of manual digit		A distal epiphysis that is part of a distal phalanx of manual digit 5.
http://purl.obolibrary.org/obo/UBERON_0014887	distal epiphysis of distal phalanx of digit	http://purl.obolibrary.org/obo/UBERON_0004448	distal epiphysis of phalanx		A distal epiphysis that is part of a distal phalanx.
http://purl.obolibrary.org/obo/UBERON_0014889	left hemisphere of cerebellum	http://purl.obolibrary.org/obo/UBERON_0002245	cerebellar hemisphere		A cerebellar hemisphere that is in_the_left_side_of a cerebellum.
http://purl.obolibrary.org/obo/UBERON_0014890	right hemisphere of cerebellum	http://purl.obolibrary.org/obo/UBERON_0002245	cerebellar hemisphere		A cerebellar hemisphere that is in_the_right_side_of a cerebellum.
http://purl.obolibrary.org/obo/UBERON_0014891	brainstem white matter	http://purl.obolibrary.org/obo/UBERON_0003544	brain white matter		White matter that is part of a brainstem [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles).
http://purl.obolibrary.org/obo/UBERON_0014903	primordial vasculature	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		A portion of tissue that will develop into vasculature.
http://purl.obolibrary.org/obo/UBERON_0014907	intersomitic vessel	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites.
http://purl.obolibrary.org/obo/UBERON_0014930	perivascular space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The space between a blood vessel and the pia mater.
http://purl.obolibrary.org/obo/UBERON_0015001	radius endochondral element	http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element		The major preaxial endrochondral skeletal element in the anterior zeugopod.
http://purl.obolibrary.org/obo/UBERON_0015002	radius-ulna endochondral element	http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element		A radius-ulna bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015003	ulna endochondral element	http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element		Major postaxial endrochondral skeletal element in the anterior zeugopod.
http://purl.obolibrary.org/obo/UBERON_0015004	tibia endochondral element	http://purl.obolibrary.org/obo/UBERON_0015022	hindlimb endochondral element		The major preaxial endochondral element in the posterior zeugopod[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0015007	cervical vertebra endochondral element	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		A vertebral endochondral element in the cervical region of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0015008	thoracic vertebra endochondral element	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		A vertebral endochondral element in the thoracic region of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0015009	lumbar vertebra endochondral element	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		A lumbar vertebra bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015010	sacral vertebra endochondral element	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		A vertebra endochondral element that is part of the sacral region of the vertebral column.
http://purl.obolibrary.org/obo/UBERON_0015013	fibula endochondral element	http://purl.obolibrary.org/obo/UBERON_0015022	hindlimb endochondral element		The major postaxial endochondral element in the posterior zeugopod[Phenoscape].
http://purl.obolibrary.org/obo/UBERON_0015014	calcaneum endochondral element	http://purl.obolibrary.org/obo/UBERON_0015050	tarsus endochondral element		A calcaneum bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015016	stapes endochondral element	http://purl.obolibrary.org/obo/UBERON_0035130	auditory ossicle endochondral element		A stapes bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015017	incus endochondral element	http://purl.obolibrary.org/obo/UBERON_0035130	auditory ossicle endochondral element		An incus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015018	malleus endochondral element	http://purl.obolibrary.org/obo/UBERON_0035130	auditory ossicle endochondral element		A malleus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015019	rib endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		A rib bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element	http://purl.obolibrary.org/obo/UBERON_0015061	limb endochondral element		A forelimb bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015022	hindlimb endochondral element	http://purl.obolibrary.org/obo/UBERON_0015061	limb endochondral element		A hindlimb bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015023	phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		A phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015023	phalanx endochondral element		A manual digit phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015025	manual digit 1 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element		A manual digit 1 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015026	manual digit 2 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element		A manual digit 2 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015027	manual digit 3 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element		A manual digit 3 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015028	manual digit 4 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element		A manual digit 4 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015029	manual digit 5 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015024	manual digit phalanx endochondral element		A manual digit 5 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015023	phalanx endochondral element		A pedal digit phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015031	pedal digit 1 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element		A pedal digit 1 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015032	pedal digit 2 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element		A pedal digit 2 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015033	pedal digit 3 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element		A pedal digit 3 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015034	pedal digit 4 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element		A pedal digit 4 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015035	pedal digit 5 phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015030	pedal digit phalanx endochondral element		A pedal digit 5 phalanx bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		A pedal digit metatarsal bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015037	pedal digit 1 metatarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		A pedal digit 1 metatarsal bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015038	pedal digit 2 metatarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		A pedal digit 2 metatarsal bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015039	pedal digit 3 metatarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		A pedal digit 3 metatarsal bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015040	pedal digit 4 metatarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		A pedal digit 4 metatarsal bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015041	pedal digit 5 metatarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		A pedal digit 5 metatarsal bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		A manual digit metacarpus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015043	manual digit 1 metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		A manual digit 1 metacarpus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015044	manual digit 2 metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		A manual digit 2 metacarpus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015045	manual digit 3 metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		A manual digit 3 metacarpus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015046	manual digit 4 metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		A manual digit 4 metacarpus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015047	manual digit 5 metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		A manual digit 5 metacarpus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		A carpus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015050	tarsus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		A tarsus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015052	femur endochondral element	http://purl.obolibrary.org/obo/UBERON_0015022	hindlimb endochondral element		A femur bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015053	humerus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015021	forelimb endochondral element		A humerus bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015054	iliac endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		An iliac bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015055	pubic endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		A pubic bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015056	ischial endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		An ischial bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015057	scapula endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		A scapula bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015059	orbitosphenoid endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		An orbitosphenoid bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015060	sphenoid endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		A sphenoid bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015061	limb endochondral element	http://purl.obolibrary.org/obo/UBERON_0010363	endochondral element		A limb bone or its cartilage or pre-cartilage precursor.
http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element	http://purl.obolibrary.org/obo/UBERON_0015061	limb endochondral element		An endochondral element that is part of a autopod region.
http://purl.obolibrary.org/obo/UBERON_0015064	autopod cartilage	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		An autopod endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015067	centrale endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		Endochondral element located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE].
http://purl.obolibrary.org/obo/UBERON_0015068	distal carpal endochondral element	http://purl.obolibrary.org/obo/UBERON_0018099	distal mesopodial endochondral element		A distal mesopodial endochondral element that is part of a forelimb.
http://purl.obolibrary.org/obo/UBERON_0015069	distal carpal cartilage element	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		A distal carpal endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015077	centrale cartilage	http://purl.obolibrary.org/obo/UBERON_0015067	centrale endochondral element		A centrale endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015078	proximal carpal endochondral element	http://purl.obolibrary.org/obo/UBERON_0017750	proximal mesopodial endochondral element		A proximal mesopodial endochondral element that is part of a forelimb.
http://purl.obolibrary.org/obo/UBERON_0015079	proximal carpal cartilage	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		A proximal carpal endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015080	proximal carpal bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015078	proximal carpal endochondral element		A proximal carpal endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015081	proximal tarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0017750	proximal mesopodial endochondral element		A proximal mesopodial endochondral element that is part of a hindlimb.
http://purl.obolibrary.org/obo/UBERON_0015082	proximal tarsal cartilage	http://purl.obolibrary.org/obo/UBERON_0035129	pes cartilage element		A proximal tarsal endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015083	proximal tarsal bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015081	proximal tarsal endochondral element		A proximal tarsal endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015085	distal carpal bone 1 cartilage	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		A distal carpal bone 1 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015086	distal carpal bone 1 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015084	distal carpal bone 1 endochondral element		A distal carpal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015088	distal carpal bone 2 cartilage	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		A distal carpal bone 2 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015089	distal carpal bone 2 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015087	distal carpal bone 2 endochondral element		A distal carpal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015091	distal carpal bone 3 cartilage	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		A distal carpal bone 3 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015092	distal carpal bone 3 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015090	distal carpal bone 3 endochondral element		A distal carpal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015094	distal carpal bone 4 cartilage	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		A distal carpal bone 4 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015095	distal carpal bone 4 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015093	distal carpal bone 4 endochondral element		A distal carpal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015099	distal tarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0018099	distal mesopodial endochondral element		A distal mesopodial endochondral element that is part of a hindlimb.
http://purl.obolibrary.org/obo/UBERON_0015100	distal tarsal cartilage	http://purl.obolibrary.org/obo/UBERON_0035129	pes cartilage element		A distal tarsal endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015101	distal tarsal bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0018101	distal mesopodial pre-cartilage condensation		A distal tarsal endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015103	distal tarsal bone 1 cartilage	http://purl.obolibrary.org/obo/UBERON_0015102	distal tarsal bone 1 endochondral element		A distal tarsal bone 1 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015104	distal tarsal bone 1 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015102	distal tarsal bone 1 endochondral element		A distal tarsal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015106	distal tarsal bone 2 cartilage	http://purl.obolibrary.org/obo/UBERON_0015105	distal tarsal bone 2 endochondral element		A distal tarsal bone 2 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015107	distal tarsal bone 2 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015105	distal tarsal bone 2 endochondral element		A distal tarsal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015109	distal tarsal bone 3 cartilage	http://purl.obolibrary.org/obo/UBERON_0015108	distal tarsal bone 3 endochondral element		A distal tarsal bone 3 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015110	distal tarsal bone 3 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015108	distal tarsal bone 3 endochondral element		A distal tarsal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015112	distal tarsal bone 4 cartilage	http://purl.obolibrary.org/obo/UBERON_0015111	distal tarsal bone 4 endochondral element		A distal tarsal bone 4 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015113	distal tarsal bone 4 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015111	distal tarsal bone 4 endochondral element		A distal tarsal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015115	distal tarsal bone 5 cartilage	http://purl.obolibrary.org/obo/UBERON_0015114	distal tarsal bone 5 endochondral element		A distal tarsal bone 5 endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0015116	distal tarsal bone 5 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015114	distal tarsal bone 5 endochondral element		A distal tarsal bone 5 endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0015120	right outer canthus	http://purl.obolibrary.org/obo/UBERON_0006726	outer canthus		An outer canthus that is in_the_right_side_of a head.
http://purl.obolibrary.org/obo/UBERON_0015121	left outer canthus	http://purl.obolibrary.org/obo/UBERON_0006726	outer canthus		An outer canthus that is in_the_left_side_of a head.
http://purl.obolibrary.org/obo/UBERON_0015122	anatomical line between outer canthi	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		An anatomical line of the face that connects the two outer (lateral) canthi of the eye. The length of this line is known as the outer canthal distance.
http://purl.obolibrary.org/obo/UBERON_0015129	epicardial fat	http://purl.obolibrary.org/obo/UBERON_0035814	pericardial fat		Visceral intrapericardial fat contiguous with the myocardial surface.
http://purl.obolibrary.org/obo/UBERON_0015130	connective tissue of prostate gland	http://purl.obolibrary.org/obo/UBERON_0011822	dense irregular connective tissue		A portion of connective tissue that is part of a prostate gland.
http://purl.obolibrary.org/obo/UBERON_0015142	falciform fat	http://purl.obolibrary.org/obo/UBERON_0015143	mesenteric fat pad		A large fat pad that is located at the base of the abdominal wall, in the falciform ligament of the liver.
http://purl.obolibrary.org/obo/UBERON_0015143	mesenteric fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		Encapsulated adipose tissue associated with the mesentery.
http://purl.obolibrary.org/obo/UBERON_0015144	autopod hair	http://purl.obolibrary.org/obo/UBERON_0037459	hair of limb		A strand of hair that is part of a autopod region.
http://purl.obolibrary.org/obo/UBERON_0015145	pes hair	http://purl.obolibrary.org/obo/UBERON_0015144	autopod hair		A strand of hair that is part of a pes.
http://purl.obolibrary.org/obo/UBERON_0015146	manus hair	http://purl.obolibrary.org/obo/UBERON_0015144	autopod hair		A strand of hair that is part of a manus.
http://purl.obolibrary.org/obo/UBERON_0015147	pinna hair	http://purl.obolibrary.org/obo/UBERON_0022279	strand of hair on external ear		A strand of hair that is part of a pinna.
http://purl.obolibrary.org/obo/UBERON_0015148	tail hair	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		A strand of hair that is part of a tail.
http://purl.obolibrary.org/obo/UBERON_0015149	ventral hair	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		A strand of hair that is part of a ventrum.
http://purl.obolibrary.org/obo/UBERON_0015150	dorsal hair	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		A strand of hair that is part of a dorsum.
http://purl.obolibrary.org/obo/UBERON_0015152	gland of ocular region	http://purl.obolibrary.org/obo/UBERON_0002530	gland		A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands.
http://purl.obolibrary.org/obo/UBERON_0015154	lateral gland of orbital region	http://purl.obolibrary.org/obo/UBERON_0015152	gland of ocular region		A gland that is located in or around the ocular region, nearer the outer canthi.
http://purl.obolibrary.org/obo/UBERON_0015155	conjunctival space	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is enclosed by a conjunctiva.
http://purl.obolibrary.org/obo/UBERON_0015156	terminal branch of ophthalmic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		The two terminal branches of the ophthalmic artery in humans are the dorsal nasal artery and the supratrochlear artery.
http://purl.obolibrary.org/obo/UBERON_0015161	inferior branch of oculomotor nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The inferior branch of the oculomotor nerve or the inferior division, the larger, divides into three branches. One passes beneath the optic nerve to the medial rectus. Another, to the inferior rectus. The third and longest runs forward between the inferior recti and lateralis to the inferior oblique. From the last a short thick branch is given off to the lower part of the ciliary ganglion, and forms its short root. All these branches enter the muscles on their ocular surfaces, with the exception of the nerve to the inferior oblique, which enters the muscle at its posterior border.
http://purl.obolibrary.org/obo/UBERON_0015165	multi-unit eye	http://purl.obolibrary.org/obo/UBERON_0000970	eye		An eye consisting of multiple light-sensing organs.
http://purl.obolibrary.org/obo/UBERON_0015172	endometrial blood vessel	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A blood vessel that is part of a endometrium.
http://purl.obolibrary.org/obo/UBERON_0015178	somite border	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		A region of somite adjacent to presomitic mesoderm.
http://purl.obolibrary.org/obo/UBERON_0015179	somite boundary epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Epithelium located in the intersomitic region.
http://purl.obolibrary.org/obo/UBERON_0015180	neck of talus	http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element		The neck of talus is directed forward and medialward, and comprises the constricted portion of the bone between the body and the oval head. Its upper and medial surfaces are rough, for the attachment of ligaments; its lateral surface is concave and is continuous below with the deep groove for the interosseous talocalcaneal ligament.
http://purl.obolibrary.org/obo/UBERON_0015181	neck of tooth	http://purl.obolibrary.org/obo/UBERON_0001560	neck of organ		The slightly constricted part of a tooth, between the crown and the root.
http://purl.obolibrary.org/obo/UBERON_0015203	non-connected functional system	http://purl.obolibrary.org/obo/UBERON_0034923	disconnected anatomical group		An anatomical group whose component structures share a common function.
http://purl.obolibrary.org/obo/UBERON_0015204	glandular system	http://purl.obolibrary.org/obo/UBERON_0015203	non-connected functional system		A non-connected functional system that is composed primarily of a gland.
http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		Any structure that is placed on one side of the left-right axis of a bilaterian.
http://purl.obolibrary.org/obo/UBERON_0015214	arcuate ligament	http://purl.obolibrary.org/obo/UBERON_0005181	thoracic segment organ		A ligament that is part of a diaphragm.
http://purl.obolibrary.org/obo/UBERON_0015228	circulatory organ	http://purl.obolibrary.org/obo/UBERON_0003103	compound organ		A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.
http://purl.obolibrary.org/obo/UBERON_0015233	nucleus of dorsal thalamus	http://purl.obolibrary.org/obo/UBERON_0007692	nucleus of thalamus		A nucleus of brain that is part of a dorsal thalamus.
http://purl.obolibrary.org/obo/UBERON_0015238	pineal complex	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		A cluster in the epithalamus that consists of the pineal body and any associated structures, such as the parapineal gland or the parietal organ. The complex is poorly developed in mammals.
http://purl.obolibrary.org/obo/UBERON_0015249	digit skin	http://purl.obolibrary.org/obo/UBERON_0015790	autopod skin		A zone of skin that is part of a digit [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0015280	pancreas left lobe	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A pancreatic lobule that is in_the_left_side_of a exocrine pancreas.
http://purl.obolibrary.org/obo/UBERON_0015281	pancreas right lobe	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A pancreatic lobule that is in_the_right_side_of a exocrine pancreas.
http://purl.obolibrary.org/obo/UBERON_0015329	respiratory system basement membrane	http://purl.obolibrary.org/obo/UBERON_0005769	basement membrane of epithelium		A basement membrane of epithelium that is part of a respiratory system.
http://purl.obolibrary.org/obo/UBERON_0015418	urethra mesenchymal layer	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		A mesenchyme that is part of a urethra.
http://purl.obolibrary.org/obo/UBERON_0015420	ureteral valve	http://purl.obolibrary.org/obo/UBERON_0003978	valve		A valve that is part of a ureter.
http://purl.obolibrary.org/obo/UBERON_0015453	subcutaneous lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is part of a hypodermis.
http://purl.obolibrary.org/obo/UBERON_0015454	pancreatic fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		A fat pad that is part of a pancreas.
http://purl.obolibrary.org/obo/UBERON_0015458	mediastinal fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		A fat pad that is part of a mediastinum.
http://purl.obolibrary.org/obo/UBERON_0015474	axilla skin	http://purl.obolibrary.org/obo/UBERON_8480025	skin of clavicle region		A zone of skin that is part of a axilla.
http://purl.obolibrary.org/obo/UBERON_0015476	nose skin	http://purl.obolibrary.org/obo/UBERON_1000021	skin of face		A zone of skin that is part of a external nose.
http://purl.obolibrary.org/obo/UBERON_0015477	axillary fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		A fat pad that is part of a axilla.
http://purl.obolibrary.org/obo/UBERON_0015479	scrotum skin	http://purl.obolibrary.org/obo/UBERON_8480029	skin of external genitalia		A zone of skin that is part of a scrotum.
http://purl.obolibrary.org/obo/UBERON_0015480	proper hepatic artery	http://purl.obolibrary.org/obo/UBERON_0001193	hepatic artery		The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery.
http://purl.obolibrary.org/obo/UBERON_0015481	left hepatic artery	http://purl.obolibrary.org/obo/UBERON_0015796	liver blood vessel		A hepatic artery that is part of a left lobe of liver.
http://purl.obolibrary.org/obo/UBERON_0015482	right hepatic artery	http://purl.obolibrary.org/obo/UBERON_0015796	liver blood vessel		A hepatic artery that is part of a right lobe of liver.
http://purl.obolibrary.org/obo/UBERON_0015485	choledocho-duodenal junction	http://purl.obolibrary.org/obo/UBERON_1100000	digestive tract junction		Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla.
http://purl.obolibrary.org/obo/UBERON_0015593	frontal gyrus	http://purl.obolibrary.org/obo/UBERON_0000200	gyrus		A gyrus that is part of a frontal cortex.
http://purl.obolibrary.org/obo/UBERON_0015716	anal canal epithelium	http://purl.obolibrary.org/obo/UBERON_0014703	anal membrane ectodermal component		An epithelium that is part of a anal canal.
http://purl.obolibrary.org/obo/UBERON_0015717	smooth muscle tissue layer of ejaculatory duct	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A smooth muscle tissue that is part of a ejaculatory duct.
http://purl.obolibrary.org/obo/UBERON_0015751	inferior tarsal muscle	http://purl.obolibrary.org/obo/UBERON_0003386	smooth muscle of eye		A smooth muscle tissue that is part of a inferior eyelid tarsus.
http://purl.obolibrary.org/obo/UBERON_0015766	epithelium of duct of salivary gland	http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct		An epithelium that is part of a duct of salivary gland.
http://purl.obolibrary.org/obo/UBERON_0015783	smooth muscle layer in fatty layer of subcutaneous tissue	http://purl.obolibrary.org/obo/UBERON_0001135	smooth muscle tissue		A smooth muscle tissue that is part of a hypodermis.
http://purl.obolibrary.org/obo/UBERON_0015787	upper respiratory conduit	http://purl.obolibrary.org/obo/UBERON_0004111	anatomical conduit		Any anatomical conduit which is part of the upper respiratory tract.
http://purl.obolibrary.org/obo/UBERON_0015788	olfactory apparatus chamber	http://purl.obolibrary.org/obo/UBERON_0015787	upper respiratory conduit		An anatomical chamber that is part of the olfactory apparatus, consisting of cavity walls (nasal epithelium and mucosal layers) and the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present.
http://purl.obolibrary.org/obo/UBERON_0015790	autopod skin	http://purl.obolibrary.org/obo/UBERON_0001419	skin of limb		A zone of skin that is part of a autopod region.
http://purl.obolibrary.org/obo/UBERON_0015791	digit connective tissue	http://purl.obolibrary.org/obo/UBERON_0003587	limb connective tissue		A portion of connective tissue that is part of a digit.
http://purl.obolibrary.org/obo/UBERON_0015796	liver blood vessel	http://purl.obolibrary.org/obo/UBERON_0003497	abdomen blood vessel		A blood vessel that is part of a liver.
http://purl.obolibrary.org/obo/UBERON_0015807	ear epithelium	http://purl.obolibrary.org/obo/UBERON_0019304	sensory organ epithelium		An epithelium that is part of a ear.
http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium	http://purl.obolibrary.org/obo/UBERON_0019304	sensory organ epithelium		An epithelium that is part of a camera-type eye.
http://purl.obolibrary.org/obo/UBERON_0015813	middle ear epithelium	http://purl.obolibrary.org/obo/UBERON_0015807	ear epithelium		An epithelium that is part of a middle ear.
http://purl.obolibrary.org/obo/UBERON_0015814	outer ear epithelium	http://purl.obolibrary.org/obo/UBERON_0015807	ear epithelium		An epithelium that is part of a external ear.
http://purl.obolibrary.org/obo/UBERON_0015833	foregut epithelium	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		An epithelium that is part of a foregut.
http://purl.obolibrary.org/obo/UBERON_0015834	duodenum lamina propria	http://purl.obolibrary.org/obo/UBERON_0001238	lamina propria of small intestine		A lamina propria that is part of a duodenum.
http://purl.obolibrary.org/obo/UBERON_0015837	incisor dental pulp	http://purl.obolibrary.org/obo/UBERON_0001754	dental pulp		A dental pulp that is part of a incisor tooth.
http://purl.obolibrary.org/obo/UBERON_0015842	incisor enamel organ	http://purl.obolibrary.org/obo/UBERON_0005176	tooth enamel organ		A tooth enamel organ that is part of a incisor tooth.
http://purl.obolibrary.org/obo/UBERON_0015846	incisor mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003856	uncondensed odontogenic mesenchyme		An odontogenic mesenchyme that is part of a incisor tooth.
http://purl.obolibrary.org/obo/UBERON_0015847	upper left incisor tooth	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A upper jaw incisor that is in_the_left_side_of a dentition.
http://purl.obolibrary.org/obo/UBERON_0015848	incisor tusk	http://purl.obolibrary.org/obo/UBERON_0010879	tusk		An incisor tooth that protrudes beyond the mouth.
http://purl.obolibrary.org/obo/UBERON_0015849	canine tusk	http://purl.obolibrary.org/obo/UBERON_0010879	tusk		An cuspid tooth that protrudes beyond the mouth.
http://purl.obolibrary.org/obo/UBERON_0015852	narwhal tusk	http://purl.obolibrary.org/obo/UBERON_0015848	incisor tusk		A upper jaw incisor that protrudes prominently from the mouth as a single median tusk, found in narwhals.
http://purl.obolibrary.org/obo/UBERON_0015853	dental pulp of median incisor tusk	http://purl.obolibrary.org/obo/UBERON_0015837	incisor dental pulp		A dental pulp that is part of a narwhal tusk.
http://purl.obolibrary.org/obo/UBERON_0015854	interpedicular line	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		An anatomical line that connects two successive vertebral pedicles. The length of this line is known as the interpedicular distance.
http://purl.obolibrary.org/obo/UBERON_0015870	lymph node of head	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is part of a head.
http://purl.obolibrary.org/obo/UBERON_0015871	facial lymph node	http://purl.obolibrary.org/obo/UBERON_0015870	lymph node of head		Any of the lymph nodes that are part of a face.
http://purl.obolibrary.org/obo/UBERON_0015873	heel skin	http://purl.obolibrary.org/obo/UBERON_0001512	skin of ankle		A zone of skin that is part of a heel.
http://purl.obolibrary.org/obo/UBERON_0015875	heel	http://purl.obolibrary.org/obo/UBERON_0005445	segment of pes		The part of the foot that is the projection of the calcaneus.
http://purl.obolibrary.org/obo/UBERON_0015917	superficial lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is located close to the surface.
http://purl.obolibrary.org/obo/UBERON_0015918	deep lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is located deeper within the organism, further from the surface.
http://purl.obolibrary.org/obo/UBERON_0016398	lymph node of lower limb	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is part of a hindlimb.
http://purl.obolibrary.org/obo/UBERON_0016399	lymph node of upper limb	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is part of a forelimb.
http://purl.obolibrary.org/obo/UBERON_0016400	infrapatellar fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		The infrapatellar fat pad, also known as Hoffa's fat pad, is a cylindrical piece of fat that is situated under and behind the patella bone within the knee.
http://purl.obolibrary.org/obo/UBERON_0016404	cervical vertebral arch joint	http://purl.obolibrary.org/obo/UBERON_0001067	vertebral arch joint		A vertebral arch joint that is part of a cervical region of vertebral column.
http://purl.obolibrary.org/obo/UBERON_0016405	pulmonary capillary	http://purl.obolibrary.org/obo/UBERON_0003526	respiratory system capillary		A capillary that is part of a lung.
http://purl.obolibrary.org/obo/UBERON_0016408	corona of glans penis	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The circumference of the base of the glans forms a rounded projecting border, the corona of the glans penis, overhanging a deep retroglandular sulcus, behind which is the neck of the penis.
http://purl.obolibrary.org/obo/UBERON_0016416	anterior chest	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		Subdivision of thorax which is anterior to the plane of the posterior boundary of the middle mediastinum.
http://purl.obolibrary.org/obo/UBERON_0016418	nasion	http://purl.obolibrary.org/obo/UBERON_0006983	anatomical point		The intersection of the frontal and two nasal bones of the human skull. Its manifestation on the visible surface of the face is a distinctly depressed area directly between the eyes, just superior to the bridge of the nose.
http://purl.obolibrary.org/obo/UBERON_0016422	compact bone of long bone	http://purl.obolibrary.org/obo/UBERON_0005808	bone tissue of long bone		A compact bone tissue that is part of a bone tissue of long bone.
http://purl.obolibrary.org/obo/UBERON_0016423	compact bone of diaphysis	http://purl.obolibrary.org/obo/UBERON_0005808	bone tissue of long bone		A compact bone tissue that is part of a diaphysis.
http://purl.obolibrary.org/obo/UBERON_0016425	epiphyseal plate of radius	http://purl.obolibrary.org/obo/UBERON_0007390	pectoral appendage cartilage tissue		An epiphyseal plate that is part of a radius bone.
http://purl.obolibrary.org/obo/UBERON_0016430	palmar branch of median nerve	http://purl.obolibrary.org/obo/UBERON_0003433	arm nerve		The palmar branch of the median nerve is a branch of the median nerve which arises at the lower part of the forearm and innervates skin of proximal central palm and thenar eminence.
http://purl.obolibrary.org/obo/UBERON_0016440	glabella region of bone	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		A zone of the frontal bone that connects the supraorbital rirdges.
http://purl.obolibrary.org/obo/UBERON_0016442	median palatine suture	http://purl.obolibrary.org/obo/UBERON_0035127	suture of hard palate		The line of junction between the horizontal parts of the palatine bones that extends from both sides of the skull to form the posterior part of the hard palate.
http://purl.obolibrary.org/obo/UBERON_0016446	hair of head	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		A strand of hair that is part of a head.
http://purl.obolibrary.org/obo/UBERON_0016447	hair of trunk	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		A strand of hair that is part of a trunk.
http://purl.obolibrary.org/obo/UBERON_0016458	esophageal hiatus	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		A hole in the diaphragm through which the esophagus passes.
http://purl.obolibrary.org/obo/UBERON_0016459	posterior pole of lens	http://purl.obolibrary.org/obo/UBERON_0019210	pole of lens		The central point on the posterior surface of the lens.
http://purl.obolibrary.org/obo/UBERON_0016462	periorbital skin	http://purl.obolibrary.org/obo/UBERON_1000021	skin of face		A zone of skin in the periorbital region of the face.
http://purl.obolibrary.org/obo/UBERON_0016464	dorsum of nose	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The midline prominence of the nose, extending from the nasal root to the tip.
http://purl.obolibrary.org/obo/UBERON_0016466	antihelix	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		On the pinna, a curved prominence of cartilage, parallel with and in front of the helix, is called the antihelix, also known as the anthelix; this divides above into two crura, the crura antihelicis, between which is a triangular depression, the fossa triangularis.
http://purl.obolibrary.org/obo/UBERON_0016467	antitragus	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The antitragus is a feature of human ear anatomy. It is a small tubercle that points anteriorly. It is separated from the tragus by the intertragic notch.
http://purl.obolibrary.org/obo/UBERON_0016475	skin of forehead	http://purl.obolibrary.org/obo/UBERON_1000021	skin of face		A zone of skin that is part of a forehead.
http://purl.obolibrary.org/obo/UBERON_0016476	primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0007115	deciduous tooth		An incisor tooth that is part of a primary dentition.
http://purl.obolibrary.org/obo/UBERON_0016478	liver stroma	http://purl.obolibrary.org/obo/UBERON_0003891	stroma		A stroma that is part of a liver.
http://purl.obolibrary.org/obo/UBERON_0016479	capsule of liver	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		A collagenous capsule covering the external surface of the liver.
http://purl.obolibrary.org/obo/UBERON_0016481	bronchial lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		A lymph node that is part of a bronchus.
http://purl.obolibrary.org/obo/UBERON_0016491	vertebral centrum element	http://purl.obolibrary.org/obo/UBERON_0004765	skeletal element		Skeletal element that functionally replaces the notochord[VSAP,modified].
http://purl.obolibrary.org/obo/UBERON_0016509	cavity of right ventricle	http://purl.obolibrary.org/obo/UBERON_0035763	cavity of cardiac chamber		Luminal space of the right ventricle of the heart.
http://purl.obolibrary.org/obo/UBERON_0016510	epithelium of male urethra	http://purl.obolibrary.org/obo/UBERON_0002325	epithelium of urethra		An epithelium that is part of a male urethra.
http://purl.obolibrary.org/obo/UBERON_0016512	lumen of duodenum	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is part of a duodenum.
http://purl.obolibrary.org/obo/UBERON_0016513	cavity of left atrium	http://purl.obolibrary.org/obo/UBERON_0035763	cavity of cardiac chamber		Luminal space of the left atrium of the heart.
http://purl.obolibrary.org/obo/UBERON_0016517	lumen of jejunum	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		An anatomical space that is part of a jejunum.
http://purl.obolibrary.org/obo/UBERON_0016520	epithelium of female urethra	http://purl.obolibrary.org/obo/UBERON_0002325	epithelium of urethra		An epithelium that is part of a female urethra.
http://purl.obolibrary.org/obo/UBERON_0016522	cavity of right atrium	http://purl.obolibrary.org/obo/UBERON_0035763	cavity of cardiac chamber		Luminal space of the right atrium of the heart.
http://purl.obolibrary.org/obo/UBERON_0016526	lobe of cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified].
http://purl.obolibrary.org/obo/UBERON_0016528	white matter of frontal lobe	http://purl.obolibrary.org/obo/UBERON_0016527	white matter of cerebral lobe		A white matter of cerebral lobe that is part of a frontal lobe.
http://purl.obolibrary.org/obo/UBERON_0016529	cortex of cerebral lobe	http://purl.obolibrary.org/obo/UBERON_0005401	cerebral hemisphere gray matter		Grey matter neocortex region of a lobe of the cerebral hemisphere.
http://purl.obolibrary.org/obo/UBERON_0016530	parietal cortex	http://purl.obolibrary.org/obo/UBERON_0016529	cortex of cerebral lobe		Gray matter of the parietal region of the neocortex, located in the parietal lobe of gyrencephalic animals. It is continuous anteriorly with the frontal cortex, posteriorly with the occipital cortex and medially with the insular cortex and with the temporal cortex on the posterior/inferior border.
http://purl.obolibrary.org/obo/UBERON_0016531	white matter of parietal lobe	http://purl.obolibrary.org/obo/UBERON_0016527	white matter of cerebral lobe		A white matter of cerebral lobe that is part of a parietal lobe.
http://purl.obolibrary.org/obo/UBERON_0016534	white matter of temporal lobe	http://purl.obolibrary.org/obo/UBERON_0016527	white matter of cerebral lobe		A white matter of cerebral lobe that is part of a temporal lobe.
http://purl.obolibrary.org/obo/UBERON_0016536	white matter of limbic lobe	http://purl.obolibrary.org/obo/UBERON_0016527	white matter of cerebral lobe		A white matter of cerebral lobe that is part of a limbic lobe.
http://purl.obolibrary.org/obo/UBERON_0016538	temporal cortex	http://purl.obolibrary.org/obo/UBERON_0016529	cortex of cerebral lobe		Gray matter of the temporal region of the neocortex, located in the temporal lobe in gyrencephalic animals.
http://purl.obolibrary.org/obo/UBERON_0016545	pharyngeal ectoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches.
http://purl.obolibrary.org/obo/UBERON_0016548	central nervous system gray matter layer	http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer		A layer of of the central nervous system that is part of gray matter.
http://purl.obolibrary.org/obo/UBERON_0016549	central nervous system white matter layer	http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer		A layer of of the central nervous system that is composed of white matter.
http://purl.obolibrary.org/obo/UBERON_0016552	phlegm	http://purl.obolibrary.org/obo/UBERON_0000912	mucus		Mucus produced in the respiratory tract.
http://purl.obolibrary.org/obo/UBERON_0016553	respiratory system mucus	http://purl.obolibrary.org/obo/UBERON_0000912	mucus		Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm).
http://purl.obolibrary.org/obo/UBERON_0016554	white matter of midbrain	http://purl.obolibrary.org/obo/UBERON_0003544	brain white matter		A white matter that is part of the midbrain.
http://purl.obolibrary.org/obo/UBERON_0016565	cerebral blood vessel	http://purl.obolibrary.org/obo/UBERON_0003499	brain blood vessel		A blood vessel that is part of a cerebellum.
http://purl.obolibrary.org/obo/UBERON_0016566	pit	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		An roughly circular indentation in a surface.
http://purl.obolibrary.org/obo/UBERON_0016611	auditory hillocks, pharyngeal arch 1 derived	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix.
http://purl.obolibrary.org/obo/UBERON_0016612	auditory hillocks, pharyngeal arch 2 derived	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus.
http://purl.obolibrary.org/obo/UBERON_0016854	dorsal part of optic cup	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The dorsal region of the optic cup that gives rise to the dorsal part of the retina.
http://purl.obolibrary.org/obo/UBERON_0016855	ventral part of optic cup	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The ventral region of the optic cup that gives rise to the ventral part of the retina.
http://purl.obolibrary.org/obo/UBERON_0016879	future central nervous system	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Primordium that develops into the central nervous system.
http://purl.obolibrary.org/obo/UBERON_0016880	future nervous system	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Primordium that develops into the nervous system.
http://purl.obolibrary.org/obo/UBERON_0016884	shoulder joint	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints.
http://purl.obolibrary.org/obo/UBERON_0016885	epithelium of terminal part of digestive tract	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		Epithelium lining the distalmost portion of the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0016886	muscle tissue of terminal part of digestive tract	http://purl.obolibrary.org/obo/UBERON_0002385	muscle tissue		Any muscle tissue of the distalmost portion of the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0016887	entire extraembryonic component	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism.
http://purl.obolibrary.org/obo/UBERON_0016888	transitional anatomical structure	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development.
http://purl.obolibrary.org/obo/UBERON_0016896	periosteum of long bone	http://purl.obolibrary.org/obo/UBERON_0002515	periosteum		A periosteum that is part of a long bone.
http://purl.obolibrary.org/obo/UBERON_0016912	frenulum of upper lip	http://purl.obolibrary.org/obo/UBERON_0016910	frenulum of lip		A frenulum of lip that is part of a upper lip.
http://purl.obolibrary.org/obo/UBERON_0016913	frenulum of lower lip	http://purl.obolibrary.org/obo/UBERON_0016910	frenulum of lip		A frenulum of lip that is part of a lower lip.
http://purl.obolibrary.org/obo/UBERON_0016915	vermilion	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		The zone of the skin that surrounds a lip and is colored red due to thin epithelium and presence of eleidin.
http://purl.obolibrary.org/obo/UBERON_0016918	upper vermilion	http://purl.obolibrary.org/obo/UBERON_0018151	skin of upper lip		A vermilion that is part of a upper lip.
http://purl.obolibrary.org/obo/UBERON_0016919	lower vermilion	http://purl.obolibrary.org/obo/UBERON_0018150	skin of lower lip		A vermilion that is part of a lower lip.
http://purl.obolibrary.org/obo/UBERON_0016928	metaphysis of fibula	http://purl.obolibrary.org/obo/UBERON_0001438	metaphysis		A metaphysis that is part of a fibula.
http://purl.obolibrary.org/obo/UBERON_0017163	skin bony tubercle	http://purl.obolibrary.org/obo/UBERON_0013703	integumentary projection		A bony structure embedded in skin, roughly equivalent to osteoderms.
http://purl.obolibrary.org/obo/UBERON_0017261	intertarsal sesamoid	http://purl.obolibrary.org/obo/UBERON_0013631	sesamoid element		A sesamoid element that is part of a tarsal skeleton.
http://purl.obolibrary.org/obo/UBERON_0017615	vomerine dentition	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		A set of teeth in which each tooth that attaches to a vomer.
http://purl.obolibrary.org/obo/UBERON_0017648	ventral body wall	http://purl.obolibrary.org/obo/UBERON_0000309	body wall		The ventral part of the body wall.
http://purl.obolibrary.org/obo/UBERON_0017649	dorsal body wall	http://purl.obolibrary.org/obo/UBERON_0000309	body wall		The dorsal part of the body wall.
http://purl.obolibrary.org/obo/UBERON_0017650	developing mesenchymal structure	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		A mesenchyme-derived anatomical entity undergoing a transtion to become another structure.
http://purl.obolibrary.org/obo/UBERON_0017651	salivary gland primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		A primordium that has the potential to develop into a saliva-secreting gland.
http://purl.obolibrary.org/obo/UBERON_0017654	buccal gland	http://purl.obolibrary.org/obo/UBERON_0000414	mucous gland		Any of the small racemose mucous glands in the mucous membrane lining the cheeks.
http://purl.obolibrary.org/obo/UBERON_0017670	bony part of cervical vertebral arch	http://purl.obolibrary.org/obo/UBERON_0016419	bony part of vertebral arch		A bony part of vertebral arch that is part of a cervical vertebral arch.
http://purl.obolibrary.org/obo/UBERON_0017671	bony part of vertebral arch of first sacral vertebra	http://purl.obolibrary.org/obo/UBERON_0016419	bony part of vertebral arch		A bony part of vertebral arch that is part of a sacral vertebra 1.
http://purl.obolibrary.org/obo/UBERON_0017672	abdominal viscera	http://purl.obolibrary.org/obo/UBERON_0005172	abdomen element		A viscus that is part of a abdomen.
http://purl.obolibrary.org/obo/UBERON_0017692	internal surface of cranial base	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		Internal (endosteal) surface of the base of skull.
http://purl.obolibrary.org/obo/UBERON_0017716	thenar eminence	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		A raised fleshy area on the palm of the hand near the base of the thumb.
http://purl.obolibrary.org/obo/UBERON_0017717	hypothenar eminence	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		Hypothenar refers to a group of three muscles of the palm that control the motion of the little finger. The three muscles are: Abductor digiti minimi Flexor digiti minimi Opponens digiti minimi.
http://purl.obolibrary.org/obo/UBERON_0017732	raphe of scrotum	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		A ridge of tissue that extends along the midline of the scrotum.
http://purl.obolibrary.org/obo/UBERON_0017748	lower primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018617	primary lower tooth		A primary incisor tooth that is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0017750	proximal mesopodial endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		A mesopodial endochondral element that is in the most proximal part of the mesopodial skeleton, connected to the zeugopodial skeleton.
http://purl.obolibrary.org/obo/UBERON_0017751	proximal mesopodial cartilage element	http://purl.obolibrary.org/obo/UBERON_0017750	proximal mesopodial endochondral element		A proximal mesopodial endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0018099	distal mesopodial endochondral element	http://purl.obolibrary.org/obo/UBERON_0015063	autopod endochondral element		An endochondral element in the distal portion of the mesopodial skeleton, between the central mesopodial skeleton and the metapodial skeleton.
http://purl.obolibrary.org/obo/UBERON_0018100	distal mesopodial cartilage element	http://purl.obolibrary.org/obo/UBERON_0018099	distal mesopodial endochondral element		A distal mesopodial endochondral element that is composed primarily of cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_0018101	distal mesopodial pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0018099	distal mesopodial endochondral element		A distal mesopodial endochondral element that is composed primarily of a pre-cartilage condensation.
http://purl.obolibrary.org/obo/UBERON_0018102	distal mesopodial bone	http://purl.obolibrary.org/obo/UBERON_0018099	distal mesopodial endochondral element		A distal mesopodial endochondral element that is composed primarily of a bone tissue.
http://purl.obolibrary.org/obo/UBERON_0018111	muscle layer of rectum	http://purl.obolibrary.org/obo/UBERON_0011198	muscle layer of large intestine		A muscle layer that is part of the rectum.
http://purl.obolibrary.org/obo/UBERON_0018112	rectum smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0016886	muscle tissue of terminal part of digestive tract		Any portion of smooth muscle tissue that is part of the rectum.
http://purl.obolibrary.org/obo/UBERON_0018113	left kidney interstitium	http://purl.obolibrary.org/obo/UBERON_0005215	kidney interstitium		A kidney interstitium that is part of a left kidney.
http://purl.obolibrary.org/obo/UBERON_0018114	right kidney interstitium	http://purl.obolibrary.org/obo/UBERON_0005215	kidney interstitium		A kidney interstitium that is part of a right kidney.
http://purl.obolibrary.org/obo/UBERON_0018115	left renal pelvis	http://purl.obolibrary.org/obo/UBERON_0001224	renal pelvis		A renal pelvis that is part of a left ureter.
http://purl.obolibrary.org/obo/UBERON_0018116	right renal pelvis	http://purl.obolibrary.org/obo/UBERON_0001224	renal pelvis		A renal pelvis that is part of a right ureter.
http://purl.obolibrary.org/obo/UBERON_0018117	left renal cortex interstitium	http://purl.obolibrary.org/obo/UBERON_0018113	left kidney interstitium		A renal cortex interstitium that is part of a left kidney.
http://purl.obolibrary.org/obo/UBERON_0018118	right renal cortex interstitium	http://purl.obolibrary.org/obo/UBERON_0018114	right kidney interstitium		A renal cortex interstitium that is part of a right kidney.
http://purl.obolibrary.org/obo/UBERON_0018119	left renal medulla interstitium	http://purl.obolibrary.org/obo/UBERON_0018113	left kidney interstitium		A renal medulla interstitium that is part of a left kidney.
http://purl.obolibrary.org/obo/UBERON_0018120	right renal medulla interstitium	http://purl.obolibrary.org/obo/UBERON_0018114	right kidney interstitium		A renal medulla interstitium that is part of a right kidney.
http://purl.obolibrary.org/obo/UBERON_0018132	tail fat pad	http://purl.obolibrary.org/obo/UBERON_0003916	fat pad		Encapsulated adipose tissue that is part of a tail.
http://purl.obolibrary.org/obo/UBERON_0018142	caudal vertebra endochondral element	http://purl.obolibrary.org/obo/UBERON_0010913	vertebral element		Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx).
http://purl.obolibrary.org/obo/UBERON_0018144	cervical rib	http://purl.obolibrary.org/obo/UBERON_0003458	neck bone		A rib that is attached to a cervical vertebra.
http://purl.obolibrary.org/obo/UBERON_0018145	lumbar rib	http://purl.obolibrary.org/obo/UBERON_0002228	rib		A rib that is attached to a lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0018146	transverse process of lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0001077	transverse process of vertebra		A transverse process that is part of a lumbar vertebra.
http://purl.obolibrary.org/obo/UBERON_0018149	angle of oral opening	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		The lateral limit of each lateral part of the oral fissure.
http://purl.obolibrary.org/obo/UBERON_0018150	skin of lower lip	http://purl.obolibrary.org/obo/UBERON_0001458	skin of lip		A zone of skin that is part of a lower lip.
http://purl.obolibrary.org/obo/UBERON_0018151	skin of upper lip	http://purl.obolibrary.org/obo/UBERON_0001458	skin of lip		A zone of skin that is part of a upper lip.
http://purl.obolibrary.org/obo/UBERON_0018154	ligament of middle ear	http://purl.obolibrary.org/obo/UBERON_0000211	ligament		A ligament that is part of a middle ear.
http://purl.obolibrary.org/obo/UBERON_0018156	malleal ligament	http://purl.obolibrary.org/obo/UBERON_0018154	ligament of middle ear		A skeletal ligament that attaches to the malleus.
http://purl.obolibrary.org/obo/UBERON_0018226	pulmonary part of lymphatic system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		An organ system subdivision that is the part of the lymphoid system that includes the pulmonary lymphatic vessels.
http://purl.obolibrary.org/obo/UBERON_0018227	pulmonary lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0003456	respiratory system lymphatic vessel		A lymphatic vessel that is part of a lung.
http://purl.obolibrary.org/obo/UBERON_0018229	renin-angiotensin system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex.
http://purl.obolibrary.org/obo/UBERON_0018232	axillary sweat gland	http://purl.obolibrary.org/obo/UBERON_0000382	apocrine sweat gland		A sweat gland that is part of a axilla.
http://purl.obolibrary.org/obo/UBERON_0018234	stroma of pancreas	http://purl.obolibrary.org/obo/UBERON_0003891	stroma		A stroma that is part of a pancreas.
http://purl.obolibrary.org/obo/UBERON_0018235	capsule of pancreas	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		A capsule that divides the parenchyma of the pancreas into lobes and lobules.
http://purl.obolibrary.org/obo/UBERON_0018239	rhombomere boundary	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		A boundary delimiting a rhombomere.
http://purl.obolibrary.org/obo/UBERON_0018243	thymic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		A vein that supplies blood to the thymus.
http://purl.obolibrary.org/obo/UBERON_0018246	thyroid vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains a thyroid gland.
http://purl.obolibrary.org/obo/UBERON_0018247	cervical thymic artery	http://purl.obolibrary.org/obo/UBERON_0018243	thymic artery		An artery that supplies a cervical thymus.
http://purl.obolibrary.org/obo/UBERON_0018251	meningeal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		One of the veins draining a meninix.
http://purl.obolibrary.org/obo/UBERON_0018252	internal pudendal vein	http://purl.obolibrary.org/obo/UBERON_0009029	pudendal vein		Accompanying vein of internal pudendal artery.
http://purl.obolibrary.org/obo/UBERON_0018255	jejunal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		A branch of the superior mesenteric artery that supplies the jejunum.
http://purl.obolibrary.org/obo/UBERON_0018256	lacrimal vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains a lacrimal gland.
http://purl.obolibrary.org/obo/UBERON_0018257	submucosa of digestive tract	http://purl.obolibrary.org/obo/UBERON_0000009	submucosa		Any portion of submucosa that lines the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0018260	layer of muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		Any organ component layer that consists of muscle tissue.
http://purl.obolibrary.org/obo/UBERON_0018261	muscular coat of digestive tract	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		A muscular coat that is part of a digestive tract.
http://purl.obolibrary.org/obo/UBERON_0018265	anterior root of zygomatic arch	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The anterior or rostral end of the zygomatic arch, which includes the temporal process of the zygomatic bone, but also including some of the body of the zygomatic bone. It may also include the zygomatico-temporal suture and the most rostral portion of the zygomatic process of the temporal bone.
http://purl.obolibrary.org/obo/UBERON_0018299	mandibular symphyseal tooth	http://purl.obolibrary.org/obo/UBERON_0003268	tooth of lower jaw		Tooth of the lower jaw that is adjacent to the mandibular symphysis.
http://purl.obolibrary.org/obo/UBERON_0018302	upper molar 1	http://purl.obolibrary.org/obo/UBERON_0018376	molar tooth 1		First molar (counting anteroposteriorly) in the upper jaw.
http://purl.obolibrary.org/obo/UBERON_0018303	adrenal tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Tissue that is part of some adrenal gland.
http://purl.obolibrary.org/obo/UBERON_0018321	foramen for glossopharyngeal nerve	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		Foramen that allows the passge of the glossopharyngeal nerve (cranial nerve IX).
http://purl.obolibrary.org/obo/UBERON_0018326	ilioischiadic foramen	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		Situated just caudal to the acetabulum, the foramen is bound dorsally by the illium and ventrally by the ischium. The foramen transmitts the ischiadic nerves and vessels (Baumel et al. 1993).
http://purl.obolibrary.org/obo/UBERON_0018376	molar tooth 1	http://purl.obolibrary.org/obo/UBERON_0003655	molar tooth		The molar tooth of the upper or lower jaw that is phylogenetically number 1.
http://purl.obolibrary.org/obo/UBERON_0018406	mental nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		Mental nerve is a general somatic afferent (sensory) nerve which provides sensation to the anterior aspects of the chin and lower lip as well as the buccal gingivae of the mandibular anterior teeth and the premolars. It is a branch of the posterior trunk of the inferior alveolar nerve, which is itself a branch of the mandibular division of the trigeminal nerve (CN V). The nerve emerges at the mental foramen in the mandibula, and divides beneath the Depressor anguli oris muscle into three branches: one descends to the skin of the chin. two ascend to the skin and mucous membrane of the lower lip. These branches communicate freely with the facial nerve.
http://purl.obolibrary.org/obo/UBERON_0018408	infra-orbital nerve	http://purl.obolibrary.org/obo/UBERON_0022298	lower eyelid nerve		A branch of the maxillary nerve that enters the infraorbital canal and innervates the lower eyelid, upper lip, the nasal vestibule, the upper incisors, canines, premolars, upper gums, lower eyelid and conjunctiva, and part of the nose.
http://purl.obolibrary.org/obo/UBERON_0018411	ligament of hip joint	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		A skeletal ligament that is part of a hip joint.
http://purl.obolibrary.org/obo/UBERON_0018413	facial nerve canal	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		A Z-shaped canal running through the temporal bone from the internal acoustic meatus to the stylomastoid foramen. It is located within the middle ear region, according to its shape it is divided into three main segments: the labyrinthine, the tympanic, and the mastoidal segment .
http://purl.obolibrary.org/obo/UBERON_0018415	ethmoid foramen	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		An bone foramen in the ethmoid bone.
http://purl.obolibrary.org/obo/UBERON_0018508	foramen of nasal bone	http://purl.obolibrary.org/obo/UBERON_0013685	foramen of skull		A vascular foramen opening on the outer surface of a nasal bone.
http://purl.obolibrary.org/obo/UBERON_0018529	female inguinal ring	http://purl.obolibrary.org/obo/UBERON_0006674	inguinal ring		An inguinal ring that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0018530	male inguinal ring	http://purl.obolibrary.org/obo/UBERON_0006674	inguinal ring		An inguinal ring that is part of a male reproductive system.
http://purl.obolibrary.org/obo/UBERON_0018531	female superficial inguinal ring	http://purl.obolibrary.org/obo/UBERON_0018529	female inguinal ring		A deep inguinal ring that is part of a female reproductive system.
http://purl.obolibrary.org/obo/UBERON_0018532	female deep inguinal ring	http://purl.obolibrary.org/obo/UBERON_0018530	male inguinal ring		A deep inguinal ring that is part of a male reproductive system.
http://purl.obolibrary.org/obo/UBERON_0018542	mandibular symphyseal region	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The region of the mandible on or near the midline (near the mandiblular symphysis).
http://purl.obolibrary.org/obo/UBERON_0018543	lumen of intestine	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The anatomical space within the intestine.
http://purl.obolibrary.org/obo/UBERON_0018544	trigeminal nerve muscle	http://purl.obolibrary.org/obo/UBERON_0001630	muscle organ		Muscle innervated by the trigeminal nerve (Cranial Nerve V).
http://purl.obolibrary.org/obo/UBERON_0018551	incisor tooth 1	http://purl.obolibrary.org/obo/UBERON_0001098	incisor tooth		The incisor tooth of the upper or lower jaw that is phylogenetically number 1.
http://purl.obolibrary.org/obo/UBERON_0018552	incisor tooth 2	http://purl.obolibrary.org/obo/UBERON_0001098	incisor tooth		The incisor tooth of the upper or lower jaw that is phylogenetically number 2.
http://purl.obolibrary.org/obo/UBERON_0018561	upper secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018621	upper canine tooth		A secondary canine tooth that is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0018562	lower secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018622	lower canine tooth		A secondary canine tooth that is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0018568	lower central secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018623	lower secondary incisor tooth		A lower jaw incisor that is in_the_central_side_of a dentition.
http://purl.obolibrary.org/obo/UBERON_0018570	lower lateral secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018623	lower secondary incisor tooth		A lower jaw incisor that is in_the_lateral_side_of a dentition.
http://purl.obolibrary.org/obo/UBERON_0018591	upper primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018616	primary upper tooth		A primary incisor tooth that is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0018593	upper central primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018603	upper central incisor tooth		A upper primary canine tooth that is in_the_central_side_of a dentition.
http://purl.obolibrary.org/obo/UBERON_0018594	upper lateral primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018604	upper lateral incisor tooth		A upper primary canine tooth that is in_the_lateral_side_of a dentition.
http://purl.obolibrary.org/obo/UBERON_0018595	lower central primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018601	lower central incisor tooth		A lower primary incisor tooth that is in_the_central_side_of a dentition.
http://purl.obolibrary.org/obo/UBERON_0018596	lower lateral primary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018602	lower lateral incisor tooth		A lower primary incisor tooth that is in_the_lateral_side_of a dentition.
http://purl.obolibrary.org/obo/UBERON_0018597	upper primary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018621	upper canine tooth		A primary canine tooth that is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0018598	lower primary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018622	lower canine tooth		A primary canine tooth that is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0018601	lower central incisor tooth	http://purl.obolibrary.org/obo/UBERON_0003451	lower jaw incisor		An incisor tooth that is in_the_central_side_of a dentition and is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0018602	lower lateral incisor tooth	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An incisor tooth that is in_the_lateral_side_of a dentition and is part of a lower jaw region.
http://purl.obolibrary.org/obo/UBERON_0018603	upper central incisor tooth	http://purl.obolibrary.org/obo/UBERON_0003450	upper jaw incisor		An incisor tooth that is in_the_central_side_of a dentition and is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0018604	upper lateral incisor tooth	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		An incisor tooth that is in_the_lateral_side_of a dentition and is part of a upper jaw region.
http://purl.obolibrary.org/obo/UBERON_0018606	molar tooth 2	http://purl.obolibrary.org/obo/UBERON_0003655	molar tooth		The molar tooth of the upper or lower jaw that is phylogenetically number 2.
http://purl.obolibrary.org/obo/UBERON_0018645	incisor region of dentition	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		The subdivision of the dentition that consists entire of incisor teeth.
http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		The neck region of a bone organ.
http://purl.obolibrary.org/obo/UBERON_0018674	heart vasculature	http://purl.obolibrary.org/obo/UBERON_0006876	vasculature of organ		An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart.
http://purl.obolibrary.org/obo/UBERON_0018679	thoracic splanchnic nerve	http://purl.obolibrary.org/obo/UBERON_0003824	nerve of thoracic segment		Thoracic splanchnic nerves are splanchnic nerves that arise from the sympathetic trunk in the thorax and travel inferiorly to provide sympathetic innervation to the abdomen. The nerves contain preganglionic sympathetic and general visceral afferent fibers.
http://purl.obolibrary.org/obo/UBERON_0019143	intramuscular adipose tissue	http://purl.obolibrary.org/obo/UBERON_0001013	adipose tissue		Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes.
http://purl.obolibrary.org/obo/UBERON_0019197	dorsal nerve of penis	http://purl.obolibrary.org/obo/UBERON_0003444	pelvis nerve		The deep terminal division of the pudendal nerve that runs along the dorsum of the penis and innervates the the corpus cavernosum penis, the prepuce and the glans penis.
http://purl.obolibrary.org/obo/UBERON_0019198	dorsal nerve of clitoris	http://purl.obolibrary.org/obo/UBERON_0003444	pelvis nerve		The deep terminal division of the pudendal nerve that runs along the dorsum of the clitoral shaft and innervates the the glans clitoris.
http://purl.obolibrary.org/obo/UBERON_0019200	skin of anterior chest	http://purl.obolibrary.org/obo/UBERON_0001868	skin of chest		Zone of skin that is part of the anterior region of the chest.
http://purl.obolibrary.org/obo/UBERON_0019204	skin epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		Any region of epithelium that is part of a skin region.
http://purl.obolibrary.org/obo/UBERON_0019207	chorioretinal region	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		The part of the eye that consists of both the retina and the optic choroid.
http://purl.obolibrary.org/obo/UBERON_0019210	pole of lens	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		A central point or region on the anterior or posterior surface of the lens.
http://purl.obolibrary.org/obo/UBERON_0019221	digit 1 or 5	http://purl.obolibrary.org/obo/UBERON_0002544	digit		Either of the outermost digits in a five-digit autopod, or their phylogenetic equivalent.
http://purl.obolibrary.org/obo/UBERON_0019222	digit 2, 3 or 4	http://purl.obolibrary.org/obo/UBERON_0002544	digit		Any of the three medial digits in a five-digit autopod, or their phylogenetic equivalent.
http://purl.obolibrary.org/obo/UBERON_0019258	white matter of hindbrain	http://purl.obolibrary.org/obo/UBERON_0003544	brain white matter		A white matter that is part of the hindbrain.
http://purl.obolibrary.org/obo/UBERON_0019261	white matter of forebrain	http://purl.obolibrary.org/obo/UBERON_0003544	brain white matter		A white matter that is part of the forebrain.
http://purl.obolibrary.org/obo/UBERON_0019262	white matter of myelencephalon	http://purl.obolibrary.org/obo/UBERON_0019258	white matter of hindbrain		A white matter that is part of the myelencephalon.
http://purl.obolibrary.org/obo/UBERON_0019307	epithelium of external nose	http://purl.obolibrary.org/obo/UBERON_0019306	nose epithelium		Epithelial layer that is part of the external part of the nose.
http://purl.obolibrary.org/obo/UBERON_0019315	meibum	http://purl.obolibrary.org/obo/UBERON_0001866	sebum		An oily substance that prevents evaporation of the eye's tear film.
http://purl.obolibrary.org/obo/UBERON_0019319	exocrine gland of integumental system	http://purl.obolibrary.org/obo/UBERON_0003297	gland of integumental system		An exocrine gland that is part of a integumental system.
http://purl.obolibrary.org/obo/UBERON_0020358	accessory XI nerve nucleus	http://purl.obolibrary.org/obo/UBERON_0007635	nucleus of medulla oblongata		The spinal accessory nucleus lies within the cervical spinal cord (C1-C5) in the ventral horn. The nucleus ambiguus is classically said to provide the 'cranial component' of the accessory nerve. However, the very existence of this cranial component has been recently questioned and seen as contributing exclusively to the vagus nerve. The terminology continues to be used in describing both human anatomy, and that of other animals.
http://purl.obolibrary.org/obo/UBERON_0020550	auricular blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		A blood vessel that supplies or drains an ear.
http://purl.obolibrary.org/obo/UBERON_0022278	nucleus of pudendal nerve	http://purl.obolibrary.org/obo/UBERON_0011777	nucleus of spinal cord		A nucleus in the ventral part of the anterior horn of the sacral region of the spinal cord that is the origin of the pudendal nerve.
http://purl.obolibrary.org/obo/UBERON_0022284	lacrimal gland bud	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		The single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation (Int Rev Cytol. 1996;168:1-80. Cell biology of the harderian gland).
http://purl.obolibrary.org/obo/UBERON_0022287	tear film	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		An aqueous substance that covers the anterior surface of the eyeball, keeping the cornea wet.
http://purl.obolibrary.org/obo/UBERON_0022293	reproductive gland secretion	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		A portion of organism substance that is secreted by a reproductive gland.
http://purl.obolibrary.org/obo/UBERON_0022296	inferior palpebral branch of infra-orbital nerve	http://purl.obolibrary.org/obo/UBERON_0022298	lower eyelid nerve		A nerve that innervates a lower eyelid and is a branch of the infra-orbital branch of the maxillary nerve.
http://purl.obolibrary.org/obo/UBERON_0022297	palpebral branch of infra-orbital nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A nerve that innervates an eyelid and is a branch of the infra-orbital branch of the maxillary nerve.
http://purl.obolibrary.org/obo/UBERON_0022298	lower eyelid nerve	http://purl.obolibrary.org/obo/UBERON_0003437	eyelid nerve		A nerve that innervates a lower eyelid.
http://purl.obolibrary.org/obo/UBERON_0022299	upper eyelid nerve	http://purl.obolibrary.org/obo/UBERON_0003437	eyelid nerve		A nerve that innervates an upper eyelid.
http://purl.obolibrary.org/obo/UBERON_0022302	short ciliary nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		A branch of the ciliary ganglion that innervates the ciliary muscles, the iris, and the tunics of the eyeball.
http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer	http://purl.obolibrary.org/obo/UBERON_0005162	multi cell part structure		Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].
http://purl.obolibrary.org/obo/UBERON_0022350	visceral serous membrane	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		Serous membrane layer that is adjacent to and lines an organ.
http://purl.obolibrary.org/obo/UBERON_0022351	parietal serous membrane	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		Serous membrane layer that lines to a body cavity.
http://purl.obolibrary.org/obo/UBERON_0022355	basal layer of endometrium	http://purl.obolibrary.org/obo/UBERON_0004811	endometrium epithelium		The layer of endometrial epithelium adjacent to the uterine cavity.
http://purl.obolibrary.org/obo/UBERON_0022358	placenta blood vessel	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A blood vessel of the placenta.
http://purl.obolibrary.org/obo/UBERON_0022360	male mammary gland duct	http://purl.obolibrary.org/obo/UBERON_0001765	mammary duct		A mammary gland duct that is part of a male organism. This structure typically regresses.
http://purl.obolibrary.org/obo/UBERON_0022361	lung field	http://purl.obolibrary.org/obo/UBERON_0007688	anlage		A specific region of the foregut into the area in which the lung will develop.
http://purl.obolibrary.org/obo/UBERON_0023879	neural system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		A set of neural structures that subserve a specific function, e.g., visual system.
http://purl.obolibrary.org/obo/UBERON_0024045	white matter of the cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0019291	white matter of metencephalon		White matter that lies deep to the granular cell layer of the cerebellar cortex. It contains afferents to the cerebellar cortex and axons that run between the cerebellar cortex and the deep cerebellar nuclei.
http://purl.obolibrary.org/obo/UBERON_0025525	motor system	http://purl.obolibrary.org/obo/UBERON_0023879	neural system		The part of the central nervous system that is involved with movement.
http://purl.obolibrary.org/obo/UBERON_0025533	proprioceptive system	http://purl.obolibrary.org/obo/UBERON_0023879	neural system		The sensory system for the sense of proprioception.
http://purl.obolibrary.org/obo/UBERON_0034670	palatal taste bud	http://purl.obolibrary.org/obo/UBERON_0034722	mouth roof taste bud		A taste bud that is located on the soft palate, in the roof of the mouth.
http://purl.obolibrary.org/obo/UBERON_0034681	vocal organ	http://purl.obolibrary.org/obo/UBERON_0000062	organ		Any organ that is the primary organ of vocalization behavior. Examples: The laryngeal vocal cord (humans), the syrinx (birds).
http://purl.obolibrary.org/obo/UBERON_0034705	developing neuroepithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An embryonic or larval epithelium that is committed to form part of the nervous system.
http://purl.obolibrary.org/obo/UBERON_0034706	proliferating neuroepithelium	http://purl.obolibrary.org/obo/UBERON_0034705	developing neuroepithelium		An epithelium that is undergoing proliferation to provide large numbers of neuronal cells.
http://purl.obolibrary.org/obo/UBERON_0034707	differentiating neuroepithelium	http://purl.obolibrary.org/obo/UBERON_0034705	developing neuroepithelium		A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells.
http://purl.obolibrary.org/obo/UBERON_0034711	cortical preplate	http://purl.obolibrary.org/obo/UBERON_0014950	layer of developing cerebral cortex		The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate.
http://purl.obolibrary.org/obo/UBERON_0034713	cranial neuron projection bundle	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain.
http://purl.obolibrary.org/obo/UBERON_0034714	epiphyseal tract	http://purl.obolibrary.org/obo/UBERON_0034713	cranial neuron projection bundle		A cranial nerve fiber tract that innervates the parietal eye.
http://purl.obolibrary.org/obo/UBERON_0034715	pineal tract	http://purl.obolibrary.org/obo/UBERON_0034714	epiphyseal tract		A cranial nerve fiber tract that innervates the pineal body.
http://purl.obolibrary.org/obo/UBERON_0034717	integumental taste bud	http://purl.obolibrary.org/obo/UBERON_0001727	taste bud		A taste bud that is located external to the digestive tube, on the head or body, as found in species such as goldfish.
http://purl.obolibrary.org/obo/UBERON_0034719	lip taste bud	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A taste bud that is located on a lip.
http://purl.obolibrary.org/obo/UBERON_0034720	head taste bud	http://purl.obolibrary.org/obo/UBERON_0034717	integumental taste bud		A taste bud that is located on the skin of the head.
http://purl.obolibrary.org/obo/UBERON_0034721	pharyngeal taste bud	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A taste bud that is located in the pharynx.
http://purl.obolibrary.org/obo/UBERON_0034722	mouth roof taste bud	http://purl.obolibrary.org/obo/UBERON_0001727	taste bud		A taste bud that is located on the roof of the mouth.
http://purl.obolibrary.org/obo/UBERON_0034724	esophageal taste bud	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		A taste bud that is located in the esophagus.
http://purl.obolibrary.org/obo/UBERON_0034726	trunk taste bud	http://purl.obolibrary.org/obo/UBERON_0034717	integumental taste bud		A taste bud that is located on the skin of the trunk.
http://purl.obolibrary.org/obo/UBERON_0034728	autonomic nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa.
http://purl.obolibrary.org/obo/UBERON_0034736	coracoclavicular ligament	http://purl.obolibrary.org/obo/UBERON_0008846	skeletal ligament		Any ligament that connects the coracoid process with the clavicle.
http://purl.obolibrary.org/obo/UBERON_0034762	areolar sweat gland	http://purl.obolibrary.org/obo/UBERON_0000382	apocrine sweat gland		Any sweat gland that is part of an areola.
http://purl.obolibrary.org/obo/UBERON_0034763	hindbrain commissure	http://purl.obolibrary.org/obo/UBERON_0005970	brain commissure		Any commissure within the hindbrain.
http://purl.obolibrary.org/obo/UBERON_0034765	glabella skin	http://purl.obolibrary.org/obo/UBERON_0016475	skin of forehead		The zone of skin that overlaps with the glabella region.
http://purl.obolibrary.org/obo/UBERON_0034766	glabella region	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		A region of the forehead corresponding to the space between the eyebrows and above the nose.
http://purl.obolibrary.org/obo/UBERON_0034768	morphological feature	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology.
http://purl.obolibrary.org/obo/UBERON_0034873	bodily gas	http://purl.obolibrary.org/obo/UBERON_0000463	organism substance		Any substance in the body or expelled from the body that is in a gaseous state.
http://purl.obolibrary.org/obo/UBERON_0034874	air in respiratory system	http://purl.obolibrary.org/obo/UBERON_0034947	gas in respiratory system		Any portion of gas located in a part of the respiratory system that is composed primarily of air.
http://purl.obolibrary.org/obo/UBERON_0034876	future neurohypophysis	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		The outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland.
http://purl.obolibrary.org/obo/UBERON_0034878	prechordal mesoderm	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		The area of axial mesoderm that develops into the prechordal plate.
http://purl.obolibrary.org/obo/UBERON_0034898	alveolar ridge of premaxilla	http://purl.obolibrary.org/obo/UBERON_0004103	alveolar ridge		The thickened ridge of bone that contains the tooth sockets on the premaxilla.
http://purl.obolibrary.org/obo/UBERON_0034901	cervical sympathetic nerve trunk	http://purl.obolibrary.org/obo/UBERON_0004295	sympathetic nerve trunk		The cervical ganglia are paravertebral ganglia of the sympathetic nervous system. These emerging postganglionic nerves synapse with preganglionic nerves from the thoracic spinal cord. They consist of three paravertebral ganglia: superior cervical ganglion middle cervical ganglion inferior cervical ganglion. The inferior ganglion may be fused with the first thoracic ganglion to form a single structure, the stellate ganglion. Nerves emerging from cervical sympathetic ganglia contribute to the cardiac plexus, among other things.
http://purl.obolibrary.org/obo/UBERON_0034903	left atrium endocardium	http://purl.obolibrary.org/obo/UBERON_0002166	endocardium of atrium		Endocardium that is part of the left atrium.
http://purl.obolibrary.org/obo/UBERON_0034907	pineal parenchyma	http://purl.obolibrary.org/obo/UBERON_0005158	parenchyma of central nervous system		Parenchymal tissue that forms the pineal gland.
http://purl.obolibrary.org/obo/UBERON_0034908	scapular muscle	http://purl.obolibrary.org/obo/UBERON_0014892	skeletal muscle organ, vertebrate		Any of the muscles that are responsible for moving the scapula. In humans these are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle.
http://purl.obolibrary.org/obo/UBERON_0034909	intermaxillary suture	http://purl.obolibrary.org/obo/UBERON_0009199	facial suture		A cranial suture in the midline of the skull that connects the left and right maxilla bones.
http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		An multicellular anatomical structure that has subparts of multiple organs as a part.
http://purl.obolibrary.org/obo/UBERON_0034922	cell cluster	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		A cluster of cells, largely surrounded by a morphological boundary.
http://purl.obolibrary.org/obo/UBERON_0034923	disconnected anatomical group	http://purl.obolibrary.org/obo/UBERON_0000465	material anatomical entity		Material anatomical entity consisting of multiple anatomical structures that are not connected to each other.
http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection	http://purl.obolibrary.org/obo/UBERON_0000465	material anatomical entity		A collection of anatomical structures that are alike in terms of their morphology or developmental origin.
http://purl.obolibrary.org/obo/UBERON_0034926	anatomical row	http://purl.obolibrary.org/obo/UBERON_0034925	anatomical collection		An anatomical collection that is arranged in a line.
http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone	http://purl.obolibrary.org/obo/UBERON_0010314	structure with developmental contribution from neural crest		A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.
http://purl.obolibrary.org/obo/UBERON_0034932	epithelium of biliary system	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts.
http://purl.obolibrary.org/obo/UBERON_0034933	layer of smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0018260	layer of muscle tissue		Any organ component layer that consists of smooth muscle tissue.
http://purl.obolibrary.org/obo/UBERON_1000004	collection of hair on external ear	http://purl.obolibrary.org/obo/UBERON_0014382	collection of hairs on head or neck		A collection of hairs that grows on the external ear.
http://purl.obolibrary.org/obo/UBERON_1000006	collection of hair on forehead	http://purl.obolibrary.org/obo/UBERON_0010165	collection of hair on face		A collection of hairs that grows on the forehead.
http://purl.obolibrary.org/obo/UBERON_1000015	skin of snout	http://purl.obolibrary.org/obo/UBERON_1000021	skin of face		A zone of skin that is part of the snout.
http://purl.obolibrary.org/obo/UBERON_1000020	collection of hair on snout	http://purl.obolibrary.org/obo/UBERON_0010165	collection of hair on face		A collection of hairs that grows on the snout.
http://purl.obolibrary.org/obo/UBERON_1000021	skin of face	http://purl.obolibrary.org/obo/UBERON_0001084	skin of head		A zone of skin that is part of the face.
http://purl.obolibrary.org/obo/UBERON_1000023	spleen pulp	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages.
http://purl.obolibrary.org/obo/UBERON_1000024	parenchyma of spleen	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		A parenchyma that is part of a spleen.
http://purl.obolibrary.org/obo/UBERON_2001269	regenerating fin/limb	http://purl.obolibrary.org/obo/UBERON_0007567	regenerating anatomical structure		Fin or limb undergoing the process of regeneration.
http://purl.obolibrary.org/obo/UBERON_2001388	epithelial mesenchymal boundary of regenerating fin/limb	http://purl.obolibrary.org/obo/UBERON_0012437	epithelial-mesenchymal boundary		An epithelial-mesenchymal boundary that is part of a regenerating fin/limb.
http://purl.obolibrary.org/obo/UBERON_2001389	regeneration epithelium of fin/limb	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a regenerating fin/limb.
http://purl.obolibrary.org/obo/UBERON_2001457	postcranial axial cartilage	http://purl.obolibrary.org/obo/UBERON_0007844	cartilage element		Cartilage which is part of the axial skeleton.
http://purl.obolibrary.org/obo/UBERON_2001626	premaxillary tooth	http://purl.obolibrary.org/obo/UBERON_0003267	tooth of upper jaw		Tooth that is attached to the premaxilla.
http://purl.obolibrary.org/obo/UBERON_2001947	hyomandibular-otic region joint	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		Joint that articulates the hyomandibular cartilage or bone and otic region cartilage or sphenotic bone, and often pterotic bone and prootic bone. Hyomandibular-otic region joint is paired.
http://purl.obolibrary.org/obo/UBERON_2001950	inter-premaxillary joint	http://purl.obolibrary.org/obo/UBERON_0000982	skeletal joint		Joint that articulates the left and right premaxillary bones. Inter-premaxillary joint is unpaired.
http://purl.obolibrary.org/obo/UBERON_2002260	premaxillary-maxillary joint	http://purl.obolibrary.org/obo/UBERON_2001950	inter-premaxillary joint		Joint that articulates the premaxilla and maxilla. Premaxillary-maxillary joint is paired.
http://purl.obolibrary.org/obo/UBERON_2005260	fenestrated capillary	http://purl.obolibrary.org/obo/UBERON_0004638	blood vessel endothelium		Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse.
http://purl.obolibrary.org/obo/UBERON_2005273	intestinal mucosal muscle	http://purl.obolibrary.org/obo/UBERON_0004221	intestine smooth muscle		A thin layer of smooth muscle immediately beneath the base of the villi which permits the intestinal mucosa to dynamically move and fold.
http://purl.obolibrary.org/obo/UBERON_2007013	preplacodal ectoderm	http://purl.obolibrary.org/obo/UBERON_0005497	non-neural ectoderm		Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes.
http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure	http://purl.obolibrary.org/obo/UBERON_0003102	surface structure		Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument.
http://purl.obolibrary.org/obo/UBERON_3000972	head external integument structure	http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure		Dermal, epidermal, glandular and pigment structures of the external head integument.
http://purl.obolibrary.org/obo/UBERON_3000977	body external integument structure	http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure		Dermal, epidermal, glandular and pigment structures of the body integument.
http://purl.obolibrary.org/obo/UBERON_3000981	limb external integument structure	http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure		Dermal, epidermal, glandular and pigment structures of the limb integument.
http://purl.obolibrary.org/obo/UBERON_3000982	tail external integument structure	http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure		Dermal, epidermal, glandular and pigment structures of the tail integument.
http://purl.obolibrary.org/obo/UBERON_3010200	vasculature of respiratory integument	http://purl.obolibrary.org/obo/UBERON_0003504	respiratory system blood vessel		Blood vessels in respiratory skin.
http://purl.obolibrary.org/obo/UBERON_4000013	mineralized skeletal tissue	http://purl.obolibrary.org/obo/UBERON_0004755	skeletal tissue		Skeletal tissue that is mineralized.
http://purl.obolibrary.org/obo/UBERON_4000020	mineralized extracellular matrix	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		Extracellular matrix that is mineralized.
http://purl.obolibrary.org/obo/UBERON_4000115	mineralized bone tissue	http://purl.obolibrary.org/obo/UBERON_4000013	mineralized skeletal tissue		Bone tissue mineralized with hydroxyapatite.
http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection	http://purl.obolibrary.org/obo/UBERON_0004529	anatomical projection		Anatomical projection that is composed of bone or cartilage tissue.
http://purl.obolibrary.org/obo/UBERON_4100117	presacral rib	http://purl.obolibrary.org/obo/UBERON_0002228	rib		Rib located anterior to the sacral region.
http://purl.obolibrary.org/obo/UBERON_4200230	surface of bone	http://purl.obolibrary.org/obo/UBERON_0006984	anatomical surface		An anatomical surface that is part of a bone.
http://purl.obolibrary.org/obo/UBERON_5001463	manual digit 1 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006048	digit 1 plus metapodial segment		A subdivision of the autopod consisting of manual digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5001466	pedal digit plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment		A subdivision of the autopod consisting of pedal digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5002389	manual digit plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment		A subdivision of the autopod consisting of manual digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003622	manual digit 2 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006049	digit 2 plus metapodial segment		A subdivision of the autopod consisting of manual digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003623	manual digit 3 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006050	digit 3 plus metapodial segment		A subdivision of the autopod consisting of manual digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003624	manual digit 4 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006051	digit 4 plus metapodial segment		A subdivision of the autopod consisting of manual digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003625	manual digit 5 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006052	digit 5 plus metapodial segment		A subdivision of the autopod consisting of manual digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003631	pedal digit 1 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006048	digit 1 plus metapodial segment		A subdivision of the autopod consisting of pedal digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003632	pedal digit 2 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006049	digit 2 plus metapodial segment		A subdivision of the autopod consisting of pedal digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003633	pedal digit 3 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006050	digit 3 plus metapodial segment		A subdivision of the autopod consisting of pedal digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003634	pedal digit 4 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006051	digit 4 plus metapodial segment		A subdivision of the autopod consisting of pedal digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5003635	pedal digit 5 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006052	digit 5 plus metapodial segment		A subdivision of the autopod consisting of pedal digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5006048	digit 1 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment		A subdivision of the autopod consisting of digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5006049	digit 2 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment		A subdivision of the autopod consisting of digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5006050	digit 3 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment		A subdivision of the autopod consisting of digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5006051	digit 4 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment		A subdivision of the autopod consisting of digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5006052	digit 5 plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5002544	digit plus metapodial segment		A subdivision of the autopod consisting of digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.
http://purl.obolibrary.org/obo/UBERON_5101463	manual digit 1 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106048	digit 1 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 1 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5101466	pedal digit digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5102389	manual digit digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_0010712	limb skeleton subdivision		A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103622	manual digit 2 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106049	digit 2 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 2 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103623	manual digit 3 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106050	digit 3 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 3 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103624	manual digit 4 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106051	digit 4 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 4 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103625	manual digit 5 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106052	digit 5 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 5 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103631	pedal digit 1 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106048	digit 1 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 1 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103632	pedal digit 2 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106049	digit 2 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 2 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103633	pedal digit 3 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106050	digit 3 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 3 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103634	pedal digit 4 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106051	digit 4 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 4 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5103635	pedal digit 5 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5106052	digit 5 digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 5 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5106048	digit 1 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of digit 1 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5106049	digit 2 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of digit 2 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5106050	digit 3 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of digit 3 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5106051	digit 4 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of digit 4 plus the associated metapodial element.
http://purl.obolibrary.org/obo/UBERON_5106052	digit 5 digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5102544	individual digit of digitopodial skeleton		A subdivision of the skeleton of the autopod consisting of the phalanges of digit 5 plus the associated metapodial element.
http://purl.obolibrary.org/obo/PR_000003457	V(D)J recombination-activating protein 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003460	V(D)J recombination-activating protein 2	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003516	lactosylceramide 4-alpha-galactosyltransferase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003777	adiponectin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003809	alpha-fetoprotein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human AFP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003862	alpha-2-HS-glycoprotein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human AHSG gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003918	albumin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ALB gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003964	intestinal alkaline phosphatase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ALPI gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003968	alkaline phosphatase, tissue-nonspecific isozyme	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ALPL gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003969	alkaline phosphatase, placental type	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ALPP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004089	aldehyde oxidase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human AOX1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004140	apolipoprotein A-I	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human APOA1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004142	apolipoprotein A-II	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human APOA2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004143	apolipoprotein A-IV	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human APOA4 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004151	apolipoprotein C-II	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human APOC2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004152	apolipoprotein C-III	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human APOC3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004155	apolipoprotein E	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human APOE gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000004580	beta-2-microglobulin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human B2M gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005061	catalase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CAT gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005178	CD9 molecule	http://purl.obolibrary.org/obo/PR_000001403	tetraspanin		A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005307	CCAAT/enhancer-binding protein alpha	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005379	complement factor H-related protein 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CFHR1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005387	properdin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CFP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005391	choriogonadotropin subunit beta	http://purl.obolibrary.org/obo/PR_000044813	glycoprotein hormone beta chain		A glycoprotein hormone beta chain that is a translation product of the human CGB3, CGB5, CGB7, or CGB8 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005423	chitinase-3-like protein 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CHI3L1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005513	creatine kinase B-type	http://purl.obolibrary.org/obo/PR_000029971	creatine kinase		A creatine kinase that is a translation product of the human CKB gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005515	creatine kinase M-type	http://purl.obolibrary.org/obo/PR_000029971	creatine kinase		A creatine kinase that is a translation product of the human CKM gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005794	ceruloplasmin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005897	C-reactive protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CRP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005931	granulocyte-macrophage colony-stimulating factor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CSF2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000005965	cystatin-C	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CST3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000006169	cell surface glycoprotein CD200 receptor 3	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000006578	DnaJ homolog subfamily B member 9	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human DNAJB9 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000006611	DNA nucleotidylexotransferase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000006678	dihydropyrimidine dehydrogenase [NADP(+)]	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human DPYD gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007431	high affinity immunoglobulin epsilon receptor subunit alpha	http://purl.obolibrary.org/obo/PR_000001355	immunoglobulin gamma Fc receptor II/III/IV		An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007439	ficolin-3	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human FCN3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007499	fibroblast growth factor 8	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007636	forkhead box protein N1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human FOXN1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007749	glucose-6-phosphate 1-dehydrogenase	http://purl.obolibrary.org/obo/PR_000050060	glucose-6-phosphate dehydrogenase		A glucose-6-phosphate dehydrogenase that is a translation product of the human G6PD gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007812	UDP-glucose 4-epimerase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GALE gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007856	gastrin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007857	erythroid transcription factor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007858	endothelial transcription factor GATA-2	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007891	pro-glucagon	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GCG gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007939	glial fibrillary acidic protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000007975	cobalamin binding intrinsic factor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CBLIF gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000008175	glucose-6-phosphate isomerase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GPI gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000008271	progranulin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human GRN gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000008725	haptoglobin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human HP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000008730	4-hydroxyphenylpyruvate dioxygenase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human HPD gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000008894	iduronate 2-sulfatase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human IDS gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000029968	somatotropin hormone family member	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide.
http://purl.obolibrary.org/obo/PR_000029971	creatine kinase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that contains a single ATP:guanido phosphotransferase N-terminal domain (Pfam:PF02807) followed by a single ATP:guanido phosphotransferase C-terminal catalytic domain (Pfam:PF00217).
http://purl.obolibrary.org/obo/PR_000044813	glycoprotein hormone beta chain	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that has a core domain composition consisting of a signal peptide followed by a single copy of the Cys_knot (Pfam:PF00007) domain. The Cysteine knot is a protein structural motif containing three disulfide bridges.
http://purl.obolibrary.org/obo/PR_000028527	casein derived peptide	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A proteolytic cleavage product that is derived from any of the casein milk proteins.
http://purl.obolibrary.org/obo/PR_P00738	haptoglobin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A haptoglobin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P01034	cystatin-C (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A cystatin-C that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P01266	thyroglobulin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A thyroglobulin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02652	apolipoprotein A-II (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An apolipoprotein A-II that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02765	alpha-2-HS-glycoprotein (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An alpha-2-HS-glycoprotein that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02771	alpha-fetoprotein (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An alpha-fetoprotein that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P05543	thyroxine-binding globulin (human)	http://purl.obolibrary.org/obo/PR_000014687	thyroxine-binding globulin		A thyroxine-binding globulin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P06732	creatine kinase M-type (human)	http://purl.obolibrary.org/obo/PR_000050097	creatine kinase (human)		A creatine kinase M-type that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P07288	prostate-specific antigen (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A prostate-specific antigen that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P08185	corticosteroid-binding globulin (human)	http://purl.obolibrary.org/obo/PR_000014686	corticosteroid-binding globulin		A corticosteroid-binding globulin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P36222	chitinase-3-like protein 1 (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A chitinase-3-like protein 1 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_Q03591	complement factor H-related protein 1 (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A complement factor H-related protein 1 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_Q10469	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (human)	http://purl.obolibrary.org/obo/PR_000010379	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase		An alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.
http://purl.obolibrary.org/obo/HP_0012830	Position	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		The anatomical localization of the specified phenotypic abnormality.
http://purl.obolibrary.org/obo/HP_0030142	Abnormal bowel sounds	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		An anomaly of the amount or nature of abdominal sounds. Abdominal sounds (bowel sounds) are made by the movement of the intestines as they promote passage of abdominal contents by peristalsis.
http://purl.obolibrary.org/obo/HP_0030143	Hyperactive bowel sounds	http://purl.obolibrary.org/obo/HP_0030142	Abnormal bowel sounds		Abnormally increased gurgling/rumbling sounds made by the movement of fluid and gas in the intestines.
http://purl.obolibrary.org/obo/HP_0030144	Hypoactive bowel sounds	http://purl.obolibrary.org/obo/HP_0030142	Abnormal bowel sounds		An decreased amount of bowel sounds.
http://purl.obolibrary.org/obo/HP_0030145	Lack of bowel sounds	http://purl.obolibrary.org/obo/HP_0030142	Abnormal bowel sounds		Complete lack of abdominal sounds as assayed by examination of the abdomen with a stethoscope.
http://purl.obolibrary.org/obo/HP_0030157	Flank pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the flank.
http://purl.obolibrary.org/obo/HP_0030669	Abnormal ocular adnexa morphology	http://purl.obolibrary.org/obo/HP_0032039	Abnormality of the ocular adnexa		A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.
http://purl.obolibrary.org/obo/HP_0040202	Abnormal consumption behavior	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		Recurrent abnormal consumption of food, liquids, or objects that could have negative consequences for the individual.
http://purl.obolibrary.org/obo/UBERON_0034945	excreted gas	http://purl.obolibrary.org/obo/UBERON_0034873	bodily gas		Any gaseous product of an excretory process.
http://purl.obolibrary.org/obo/UBERON_0034946	gas excreted from digestive tract	http://purl.obolibrary.org/obo/UBERON_0034945	excreted gas		Any excreted gas that is produced by the digestive tract.
http://purl.obolibrary.org/obo/UBERON_0035371	retroperitoneal lymph node	http://purl.obolibrary.org/obo/UBERON_0002075	viscus		A lymph node located in the retroperitoneal space.
http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology	http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology		A structural anomaly of a neuron. Neurons are electrically excitable cells that transmit signals throughout the body. Neurons employ both electrical and chemical components in the transmission of information. Neurons are connected to other neurons at synapses and connected to effector organs or cells at neuroeffector junctions.
http://purl.obolibrary.org/obo/HP_0012758	Neurodevelopmental delay	http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental abnormality		Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems.
http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental abnormality	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities.
http://purl.obolibrary.org/obo/HP_0012785	Flexion contracture of finger	http://purl.obolibrary.org/obo/HP_0034681	Finger joint contracture		Chronic loss of joint motion in a finger due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0012791	Abnormal humeral ossification	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		An anomaly of the process of formation of bone in the humerus.
http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		A morphological abnormality of the optic disc, i.e., of the portion of the optic nerve clinically visible on fundoscopic examination.
http://purl.obolibrary.org/obo/HP_0012812	Fullness of paranasal tissue	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Increased bulk of tissue alongside the nose. The fullness can be caused by both bony and soft tissues.
http://purl.obolibrary.org/obo/HP_0012815	Hypoplastic female external genitalia	http://purl.obolibrary.org/obo/HP_0003241	External genital hypoplasia		Underdevelopment of part or all of the female external reproductive organs (which include the mons pubis, labia majora, labia minora, Bartholin glands, and clitoris).
http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier	http://purl.obolibrary.org/obo/HP_0000001	All		This subontology is designed to provide terms to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects.
http://purl.obolibrary.org/obo/HP_0012841	Retinal vascular tortuosity	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		An increased number of twists and turns of the retinal blood vessels. This can affect either arteries, veins or both.
http://purl.obolibrary.org/obo/HP_0012874	Abnormal male reproductive system physiology	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of reproductive system physiology		An abnormal functionality of the male genital system.
http://purl.obolibrary.org/obo/HP_0012880	Abnormal labia minora morphology	http://purl.obolibrary.org/obo/HP_0000058	Abnormal labia morphology		An anomaly of the labia minora, the folds of skin between the outer labia.
http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology	http://purl.obolibrary.org/obo/HP_0000058	Abnormal labia morphology		An anomaly of the outer labia.
http://purl.obolibrary.org/obo/HP_0025021	Abnormal erythrocyte sedimentation rate	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		A deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.
http://purl.obolibrary.org/obo/HP_0025028	Abnormal enteric nervous system morphology	http://purl.obolibrary.org/obo/HP_0012331	Abnormal autonomic nervous system morphology		A structural anomaly of nerves of the enteric nervous system.
http://purl.obolibrary.org/obo/HP_0025057	Abnormal olfactory lobe morphology	http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology		A structural anomaly of the olfactory lobe, the structure within the brain that receives neural input from the nasal cavity and thereby processes the sense of smell.
http://purl.obolibrary.org/obo/HP_0025085	Bloody diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		Passage of many stools containing blood.
http://purl.obolibrary.org/obo/HP_0025104	Capillary malformation	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A capillary malformation is a flat, sharply defined vascular stain of the skin. It may cover a large surface area or it may be scattered and appear as little islands of color. In a capillary maformation, the predominant vessels are small, slow-flow vessels (i.e., arterioles and postcapillary venules).
http://purl.obolibrary.org/obo/HP_0025112	Auditory sensitivity	http://purl.obolibrary.org/obo/HP_5200058	Sensory hypersensitivity		Decreased tolerance to sound.
http://purl.obolibrary.org/obo/HP_0025125	White lesion of the oral mucosa	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		White lesions of the oral mucosa are generally caused by a condition that increases the thickness of the epithelium. This increases the distance to the vascular bed and thereby tends to change the usual reddish color of the oral mucosa to white. Common causes include hyperkeratosis (thickening of the keratin layer), acanthosis (thickening of the spinous cell layer), increased edema in the epithelium (leukoedema), and reduced vascularity of the underlying lamina propria. Additionally, fibrin caps or surface ulcerations and collapsed bullae can appear white.
http://purl.obolibrary.org/obo/HP_0025155	Abnormal hepatobiliary system physiology	http://purl.obolibrary.org/obo/HP_0025032	Abnormality of digestive system physiology		A functional anomaly of the hepatobiliary system
http://purl.obolibrary.org/obo/HP_0025270	Abnormal esophagus physiology	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		Any physiological abnormality of the esophagus.
http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology	http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the integument		Any functional anomaly of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.
http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity	http://purl.obolibrary.org/obo/HP_0002960	Autoimmunity		The presence of an antibody in the blood circulation that is directed against the organism's own cells or tissues.
http://purl.obolibrary.org/obo/HP_0030067	Peripheral primitive neuroectodermal neoplasm	http://purl.obolibrary.org/obo/HP_0030065	Primitive neuroectodermal tumor		A primitive neuroectodermal neoplasm that occurs extracranially in soft tissue and bone.
http://purl.obolibrary.org/obo/HP_0030082	Abnormal drinking behavior	http://purl.obolibrary.org/obo/HP_0040202	Abnormal consumption behavior		Abnormal consumption of fluids with excessive or insufficient consumption of fluid or any other abnormal pattern of fluid consumption.
http://purl.obolibrary.org/obo/HP_0030084	Clinodactyly	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe).
http://purl.obolibrary.org/obo/HP_0030085	Abnormal CSF lactate concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Abnormal concentration of lactate in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0030141	Abnormality of the posterior hairline	http://purl.obolibrary.org/obo/HP_0009553	Abnormality of the hairline		An anomaly in the placement or shape of the hairline (trichion) on the back of the head (neck), that is, the border between skin on the back of the head that has head hair.
http://purl.obolibrary.org/obo/HP_0030163	Abnormal vascular physiology	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Abnormality of vascular function.
http://purl.obolibrary.org/obo/HP_0030173	Peripheral hypermyelination	http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination		Increased amount of peripheral myelination.
http://purl.obolibrary.org/obo/HP_0030177	Abnormality of peripheral nervous system electrophysiology	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		An abnormality of the function of the electrical signals with which peripheral nerve cells communicate with each other or with muscles.
http://purl.obolibrary.org/obo/HP_0030182	Tetraplegia/tetraparesis	http://purl.obolibrary.org/obo/HP_0010549	Weakness due to upper motor neuron dysfunction		Loss of strength in all four limbs. Tetraplegia refers to a complete loss of strength, whereas Tetraparesis refers to an incomplete loss of strength.
http://purl.obolibrary.org/obo/HP_0030186	Kinetic tremor	http://purl.obolibrary.org/obo/HP_0002345	Action tremor		Tremor that occurs during any voluntary movement. It may include visually or non-visually guided movements. Tremor during target directed movement is called intention tremor.
http://purl.obolibrary.org/obo/HP_0030187	Titubation	http://purl.obolibrary.org/obo/HP_0002345	Action tremor		Nodding movement of the head or body.
http://purl.obolibrary.org/obo/HP_0030188	Tremor by anatomical site	http://purl.obolibrary.org/obo/HP_0001337	Tremor		Tremor classified by the affected body part.
http://purl.obolibrary.org/obo/HP_0030191	Abnormal peripheral nervous system synaptic transmission	http://purl.obolibrary.org/obo/HP_0012535	Abnormal synaptic transmission		An anomaly in the communication from a neuron to a target across a synapse in the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0030236	Abnormality of muscle size	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Abnormalities of the overall muscle bulk based on clinical observation.
http://purl.obolibrary.org/obo/HP_0030237	Hand muscle weakness	http://purl.obolibrary.org/obo/HP_0001421	Abnormality of the musculature of the hand		Reduced strength of the musculature of the hand.
http://purl.obolibrary.org/obo/HP_0030256	Small intestinal polyposis	http://purl.obolibrary.org/obo/HP_0200008	Intestinal polyposis		The presence of multiple polyps in the small intestine.
http://purl.obolibrary.org/obo/HP_0030277	Abnormal vertebral pedicle morphology	http://purl.obolibrary.org/obo/HP_0008438	Vertebral arch anomaly		Abnormal morphology of a vertebral pedical.
http://purl.obolibrary.org/obo/HP_0030289	Flattened femoral epiphysis	http://purl.obolibrary.org/obo/HP_0003071	Flattened epiphysis		An abnormal flattening of an epiphysis of femur.
http://purl.obolibrary.org/obo/HP_0030291	Lower-limb metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0003025	Metaphyseal irregularity		Irregularity of the normally smooth surface of one or more metaphyses of a bone of the leg.
http://purl.obolibrary.org/obo/HP_0030304	Abnormal number of vertebrae	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		A deviation from the normal number of vertebrae in the spinal column.
http://purl.obolibrary.org/obo/HP_0030307	Flared lower limb metaphysis	http://purl.obolibrary.org/obo/HP_0003015	Flared metaphysis		The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the leg.
http://purl.obolibrary.org/obo/HP_0030310	Upper extremity joint dislocation	http://purl.obolibrary.org/obo/HP_0001373	Joint dislocation		Displacement or malalignment of one or more joints in the upper extremity (arm).
http://purl.obolibrary.org/obo/HP_0030311	Lower extremity joint dislocation	http://purl.obolibrary.org/obo/HP_0001373	Joint dislocation		Displacement or malalignment of one or more joints in the lower extremity (leg).
http://purl.obolibrary.org/obo/HP_0030314	Periostosis	http://purl.obolibrary.org/obo/HP_0030313	Abnormal periosteum morphology		Abnormal deposition of periosteal bone.
http://purl.obolibrary.org/obo/HP_0030338	Abnormal circulating gonadotropin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
http://purl.obolibrary.org/obo/HP_0030402	Abnormal platelet aggregation	http://purl.obolibrary.org/obo/HP_0011869	Abnormal platelet function		An abnormality in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent.
http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma	http://purl.obolibrary.org/obo/HP_0100242	Sarcoma		A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues.
http://purl.obolibrary.org/obo/HP_0030450	Neoplasm of the autonomic nervous system	http://purl.obolibrary.org/obo/HP_0100007	Neoplasm of the peripheral nervous system		A tumor that arises from an element of the autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		An area anywhere within the retina showing pale yellow or white discoloration. Such lesions can be flat or raised and there size can range from very small to big.
http://purl.obolibrary.org/obo/HP_0030637	Congenital stationary cone dysfunction	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		Retinal phenotype characterized by cone photoreceptor dysfunction and preserved rod system. The abnormality is typically stationary or very slowly progressive and findings may include reduced central vision, color vision abnormalities, nystagmus and photophobia.
http://purl.obolibrary.org/obo/HP_0030680	Abnormal cardiovascular system morphology	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of the cardiovascular system		Any structural anomaly of the heart and blood vessels.
http://purl.obolibrary.org/obo/HP_0030780	Abnormality of the protein C anticoagulant pathway	http://purl.obolibrary.org/obo/HP_0003256	Abnormality of the coagulation cascade		An anomaly of the protein C anticoagulant pathway, which serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. A natural anticoagulant system denoted the protein C pathway exerts its anticoagulant effect by regulating the activity of FVIIIa and FVa. The vitamin K-dependent protein C is the key component of the pathway. Activated protein C (APC) cleaves and inhibits coagulation cofactors FVIIIa and FVa, which result in downregulation of the activity of the coagulation system. The endothelial protein C receptor stimulates the T-TM-mediated activation of protein C on the endothelial cell surface. The two cofactors, protein S and the intact form of FV, enhance the anticoagulant activity of APC.
http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla.
http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		Any structural anomaly of the tongue.
http://purl.obolibrary.org/obo/HP_0030810	Abnormal tongue physiology	http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology		Any functional anomaly of the tongue.
http://purl.obolibrary.org/obo/HP_0030872	Abnormal cardiac ventricular function	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		An abnormality of the cardiac ventricular function.
http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation	http://purl.obolibrary.org/obo/HP_0030163	Abnormal vascular physiology		A functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart.
http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.
http://purl.obolibrary.org/obo/HP_0030886	Abnormal T cell apoptosis	http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology		Abnormal apoptosis by peripheral blood T cells in an in vitro culture, compared to a healthy control sample. May be either spontaneous, induced by UV, X-ray, FasL or other agens. Commonly measured by surface expression of phosphatidyl serine labelled by Annexin V, but other methods such as staning of cleaved Caspases may be used by different laboratories.
http://purl.obolibrary.org/obo/HP_0030895	Abnormal gastrointestinal motility	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		An anomaly of the muscular contractions that propel food though the gastrointestinal tract.
http://purl.obolibrary.org/obo/HP_0030949	Glomerular deposits	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		An abnormal accumulation of protein in the glomerulus.
http://purl.obolibrary.org/obo/HP_0040012	Chromosome breakage	http://purl.obolibrary.org/obo/HP_0003220	Abnormality of chromosome stability		Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents.
http://purl.obolibrary.org/obo/HP_0040063	Decreased adipose tissue	http://purl.obolibrary.org/obo/HP_0009124	Abnormal adipose tissue morphology		The amount of adipose tissue (fat) in the body or a part of the body is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		Any structural anomaly of the ulna, a bone of the forearm the extends from the elbow to the little finger.
http://purl.obolibrary.org/obo/HP_0040081	Abnormal circulating creatine kinase activity	http://purl.obolibrary.org/obo/HP_0011021	Abnormal circulating enzyme concentration		Any deviation from the normal activity of creatine kinase in the blood circulation.
http://purl.obolibrary.org/obo/HP_0040084	Abnormal circulating renin concentration	http://purl.obolibrary.org/obo/HP_0000847	Abnormality of renin-angiotensin system		A deviation from the normal concentration of renin in the blood, a central hormone in the control of blood pressure and various other physiological functions.
http://purl.obolibrary.org/obo/HP_0040095	Neoplasm of the outer ear	http://purl.obolibrary.org/obo/HP_0012780	Neoplasm of the ear		A tumor (abnormal growth of tissue) of the outer ear.
http://purl.obolibrary.org/obo/HP_0040130	Abnormal circulating iron concentration	http://purl.obolibrary.org/obo/HP_0011031	Abnormality of iron homeostasis		The concentration of iron in the blood circulation is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0040133	Abnormal circulating ferritin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		A deviation from the normal circulating concentration of ferritin. Ferritin concentration can be measured in serum or plasma.
http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid	http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria		An increased amount of carboxylic acid in the urine.
http://purl.obolibrary.org/obo/HP_0040194	Increased head circumference	http://purl.obolibrary.org/obo/HP_0000240	Abnormality of skull size		An abnormally increased head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart.
http://purl.obolibrary.org/obo/HP_0040195	Decreased head circumference	http://purl.obolibrary.org/obo/HP_0000240	Abnormality of skull size		An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean.
http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm	http://purl.obolibrary.org/obo/HP_0100871	Abnormal palm morphology		An abnormality of the skin of the palm, that is, the skin of the front of the hand.
http://purl.obolibrary.org/obo/HP_0045010	Abnormal peripheral nerve morphology by anatomical site	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Abnormal morphology of a specific peripheral nerve
http://purl.obolibrary.org/obo/HP_0045017	Congenital malformation of the left heart	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Defect or defects of the morphogenesis of the left heart identifiable at birth.
http://purl.obolibrary.org/obo/HP_0045058	Abnormality of the testis size	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		An anomaly of the size of the testicle (the male gonad).
http://purl.obolibrary.org/obo/HP_0045073	Serositis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation in any serous cavity.
http://purl.obolibrary.org/obo/HP_0045074	Thin eyebrow	http://purl.obolibrary.org/obo/HP_0100840	Aplasia/Hypoplasia of the eyebrow		Decreased diameter of eyebrow hairs.
http://purl.obolibrary.org/obo/HP_0045075	Sparse eyebrow	http://purl.obolibrary.org/obo/HP_0100840	Aplasia/Hypoplasia of the eyebrow		Decreased density/number of eyebrow hairs.
http://purl.obolibrary.org/obo/HP_0410008	Abnormality of the peripheral nervous system	http://purl.obolibrary.org/obo/HP_0000707	Abnormality of the nervous system		Any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord.
http://purl.obolibrary.org/obo/HP_3000003	Abnormal mandibular ramus morphology	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		An abnormality of a mandibular ramus.
http://purl.obolibrary.org/obo/HP_3000004	Abnormal frontalis muscle physiology	http://purl.obolibrary.org/obo/HP_0040172	Abnormality of occipitofrontalis muscle		Abnormal function of the frontalis muscle, which covers parts of the forehead and is responsible for raising the eyebrows.
http://purl.obolibrary.org/obo/HP_3000030	Abnormal morphology of bony orbit of skull	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		An abnormality of an orbit of skull.
http://purl.obolibrary.org/obo/HP_3000036	Abnormal head blood vessel morphology	http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology		An abnormality of a blood vessel of the head, including branches of the arterial and venous systems of the head.
http://purl.obolibrary.org/obo/HP_3000050	Abnormal odontoid tissue morphology	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the skeletal system		An abnormality of an odontoid tissue.
http://purl.obolibrary.org/obo/MPATH_119	hemorrhage and non-specified extravasation	http://purl.obolibrary.org/obo/MPATH_105	circulatory disorder		Abnormal release of whole blood or the cellular component from the circulation.
http://purl.obolibrary.org/obo/MPATH_120	ecchymosis	http://purl.obolibrary.org/obo/MPATH_119	hemorrhage and non-specified extravasation		A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae.
http://purl.obolibrary.org/obo/MPATH_156	parakeratosis	http://purl.obolibrary.org/obo/MPATH_154	hyperkeratosis		Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum.
http://purl.obolibrary.org/obo/MPATH_184	sclerosis	http://purl.obolibrary.org/obo/MPATH_176	connective tissue replacement		Any pathological thickening or hardening of a tissue.
http://purl.obolibrary.org/obo/MPATH_197	glomerulonephritis	http://purl.obolibrary.org/obo/MPATH_212	inflammation		Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment.
http://purl.obolibrary.org/obo/MPATH_198	immune mediated hemolytic anaemia	http://purl.obolibrary.org/obo/MPATH_212	inflammation		An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction.
http://purl.obolibrary.org/obo/MPATH_201	vasculitis	http://purl.obolibrary.org/obo/MPATH_212	inflammation		Inflammation of a blood vessel.
http://purl.obolibrary.org/obo/MPATH_28	atherosclerosis	http://purl.obolibrary.org/obo/MPATH_25	tissue specific degenerative process		Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification.
http://purl.obolibrary.org/obo/MPATH_31	emphysema	http://purl.obolibrary.org/obo/MPATH_25	tissue specific degenerative process		Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number.
http://purl.obolibrary.org/obo/MPATH_36	calcium deposition	http://purl.obolibrary.org/obo/MPATH_555	mineralisation		Intra or extracellular deposition of calcium usually as calcium phosphate.
http://purl.obolibrary.org/obo/MPATH_476	telangiectasia	http://purl.obolibrary.org/obo/MPATH_474	ectasia		A lesion formed by a dilated capillary or terminal artery.
http://purl.obolibrary.org/obo/MPATH_502	monocytic leukaemia	http://purl.obolibrary.org/obo/MPATH_342	myeloid leukaemia		Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts.
http://purl.obolibrary.org/obo/MPATH_579	ulcer	http://purl.obolibrary.org/obo/MPATH_1	cell and tissue damage		Loss of epithelium and the basement membrane (full thickness). Cf Erosion.
http://purl.obolibrary.org/obo/MPATH_608	abscess	http://purl.obolibrary.org/obo/MPATH_607	healing and repair structure		A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.
http://purl.obolibrary.org/obo/MPATH_62	cyst	http://purl.obolibrary.org/obo/MPATH_56	developmental or adult structural  defect		Formation of an epithelium bounded cavity not associated with neoplasia.
http://purl.obolibrary.org/obo/MPATH_68	diverticulum	http://purl.obolibrary.org/obo/MPATH_56	developmental or adult structural  defect		A blind ended outpouching through the wall of a tubular organ or bounded cavity.
http://purl.obolibrary.org/obo/MPATH_70	fistula	http://purl.obolibrary.org/obo/MPATH_56	developmental or adult structural  defect		An abnormal passage between two internal organs or leading from a cavity to the body surface.
http://purl.obolibrary.org/obo/MPATH_74	hamartoma	http://purl.obolibrary.org/obo/MPATH_56	developmental or adult structural  defect		A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477.
http://purl.obolibrary.org/obo/MPATH_90	aneurysm	http://purl.obolibrary.org/obo/MPATH_56	developmental or adult structural  defect		Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber.
http://purl.obolibrary.org/obo/NBO_0000011	social behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		"A behavior that occurs predominantly or only, in individuals that are part of a group." [Wikipedia:Social_behavior]
http://purl.obolibrary.org/obo/NBO_0000043	bonding behavior	http://purl.obolibrary.org/obo/NBO_0000280	attraction-related behavior		A behavior that occurs between two individuals, such as parent and child, and involves an emotional attachment that implies a special and focused relationship.
http://purl.obolibrary.org/obo/NBO_0000075	playing behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		A very broad category including the partial or complete performance of adult functional behaviors in non-functional contexts, as well as interactive behaviors peculiar to immature animals [NBO:AC]
http://purl.obolibrary.org/obo/NBO_0000313	behavior process	http://purl.obolibrary.org/obo/GO_0007610	behavior		"The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610]
http://purl.obolibrary.org/obo/NBO_0000417	physiologic nystagmus	http://purl.obolibrary.org/obo/NBO_0000416	vestibulo-ocular reflex		"A form of involuntary eye movement that is part of the vestibulo-ocular reflex (VOR). It is characterized by alternating smooth pursuit in one direction and saccadic movement in the other direction." [wikipedia:Physiologic_nystagmus]
http://purl.obolibrary.org/obo/NBO_0000604	social inhibition	http://purl.obolibrary.org/obo/NBO_0000011	social behavior		"A social behavior characterised by conscious or unconscious constraint of a behavior that might be considered objectionable in a social setting." [wikipedia:Social_inhibition]
http://purl.obolibrary.org/obo/NBO_0000616	eye contact	http://purl.obolibrary.org/obo/NBO_0000613	nonverbal communication behavior		"A nonverbal communication behavior that is characterised by the meeting the eyes between two individuals." [wikipedia:Eye_contact]
http://purl.obolibrary.org/obo/UBERON_0035116	diastema between upper central incisors	http://purl.obolibrary.org/obo/UBERON_0035115	diastema between central incisors		A space or gap between the left and right central incisors on the upper jaw.
http://purl.obolibrary.org/obo/UBERON_0035133	longitudinal arch of pes	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		A curved region of the skeleton of the pes (foot) formed by the tarsal and metatarsal bones.
http://purl.obolibrary.org/obo/UBERON_0035550	superficial vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers.
http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region	http://purl.obolibrary.org/obo/UBERON_0000001	gross anatomical part		Material anatomical entity that forms the outermost boundary of an anatomical structure.
http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology	http://purl.obolibrary.org/obo/HP_0000769	Abnormality of the breast		Any anomaly of the structure of the breast.
http://purl.obolibrary.org/obo/PATO_0045001	normal object quality	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		A quality of an object that has a value that is normal or average.
http://purl.obolibrary.org/obo/PATO_0045065	normal fatigability	http://purl.obolibrary.org/obo/PATO_0045064	normal strength		A fatigability which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045031	normal mass density	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A density which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045008	normal cellular motility	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A cellular motility which is normal or average.
http://purl.obolibrary.org/obo/PATO_0045073	normal process quality	http://purl.obolibrary.org/obo/PATO_0001236	process quality		A quality of a process that has a value that is normal or average.
http://purl.obolibrary.org/obo/PATO_0045016	normal elasticity	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		An elasticity which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045011	normal contractility	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A contractility which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045009	normal coiling	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A coiling which is normal or average.
http://purl.obolibrary.org/obo/PATO_0045002	normal acidity	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		An acidity which is relatively normal.
http://purl.obolibrary.org/obo/HP_0031797	Clinical course	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual.
http://purl.obolibrary.org/obo/HP_0031801	Vocal cord dysfunction	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		Any functional anomaly of the vocal cord.
http://purl.obolibrary.org/obo/HP_0031803	Fundus hemorrhage	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Bleeding within the fundus of the eye.
http://purl.obolibrary.org/obo/CHEBI_142533	->4)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		An organic group forming part of, and a proposed epitope within, globoside G<small><sub>M1</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_142567	alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group	http://purl.obolibrary.org/obo/CHEBI_30697	beta-D-glucosyl group		A trisaccharide β-<small>D</small>-glucosyl group obtained by removal of the hydroxy group from the hemiacetal function of α-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucose. Part of, and the proposed epitope from, α-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucosyl-(1↔1)-ceramide (globoside G<small><sub>b3</sub></small>Cer; globotriosylceramide; CTH).
http://purl.obolibrary.org/obo/CHEBI_142590	3-aminoisobutanoic acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		Zwitterionic form of 3-aminoisobutyric acid arising from migration of a proton from the carboxy group to the amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/HP_0020219	Motor seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A motor seizure is a type of seizure that is characterized at onset by involvement of the skeletal musculature. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.
http://purl.obolibrary.org/obo/HP_0032572	Abnormal urinary nucleobase concentration	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		A deviation from the normal level of a nucleobase in the urine. Nucleobases are nitrogen-containing biological compounds that form nucleosides: adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U).
http://purl.obolibrary.org/obo/HP_0032618	Renal necrosis	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Cell death (necrosis) affecting one or more parts of the kidney.
http://purl.obolibrary.org/obo/HP_0032663	Focal motor status epilepticus	http://purl.obolibrary.org/obo/HP_0032658	Status epilepticus with prominent motor symptoms		Status epilepticus with focal motor signs originating within networks limited to one hemisphere. Involves musculature in any form. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.
http://purl.obolibrary.org/obo/PATO_0040034	fractured	http://purl.obolibrary.org/obo/PATO_0001444	broken		A broken quality where an entity is cracked or broken, usually a bone.
http://purl.obolibrary.org/obo/PATO_0040040	compression-fractured	http://purl.obolibrary.org/obo/PATO_0040034	fractured		A fractured quality that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.
http://purl.obolibrary.org/obo/PATO_0040041	avulsion fractured	http://purl.obolibrary.org/obo/PATO_0040034	fractured		A fractured quality in which the fragment of bone tears away from the main mass of bone as a result of physical trauma.
http://purl.obolibrary.org/obo/HP_0033020	Female reproductive system neoplasm	http://purl.obolibrary.org/obo/HP_0010787	Genital neoplasm		A neoplasm that affects the female reproductive system.
http://purl.obolibrary.org/obo/CL_0001082	immature innate lymphoid cell	http://purl.obolibrary.org/obo/CL_0001065	innate lymphoid cell		An innate lyphoid cell with an immature phenotype.
http://purl.obolibrary.org/obo/CL_0011026	progenitor cell	http://purl.obolibrary.org/obo/CL_0011115	precursor cell		A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.
http://purl.obolibrary.org/obo/CL_0019017	lymphatic vessel smooth muscle cell	http://purl.obolibrary.org/obo/CL_0000359	vascular associated smooth muscle cell		A smooth muscle cell that is part of any lymphatic vessel.
http://purl.obolibrary.org/obo/CL_0019018	blood vessel smooth muscle cell	http://purl.obolibrary.org/obo/CL_0000359	vascular associated smooth muscle cell		A smooth muscle cell that is part of any blood vessel.
http://purl.obolibrary.org/obo/CL_0019019	tracheobronchial smooth muscle cell	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell that is part of the tracheobronchial tree.
http://purl.obolibrary.org/obo/CHEBI_166902	noradrenaline(1+)	http://purl.obolibrary.org/obo/CHEBI_35274	ammonium ion derivative		An organic cation that is the conjugate acid of noradrenaline, obtained by protonation of the primary amino group; major species at pH 7.3.
http://purl.obolibrary.org/obo/UBERON_8400021	liver serosa	http://purl.obolibrary.org/obo/UBERON_0000042	serous membrane		Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact.
http://purl.obolibrary.org/obo/UBERON_8400023	liver subserosa	http://purl.obolibrary.org/obo/UBERON_0012375	subserosa		Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson.
http://purl.obolibrary.org/obo/UBERON_8400024	subcapsular region of liver	http://purl.obolibrary.org/obo/UBERON_0001280	liver parenchyma		Region of liver parenchyma immediately below the capsule. This region is frequently specified in pathology diagnoses.
http://purl.obolibrary.org/obo/UBERON_8410000	duodeno-jejunal junction	http://purl.obolibrary.org/obo/UBERON_8410024	intestinal junction		The anatomical junction between the duodenum and the jejunum.
http://purl.obolibrary.org/obo/UBERON_8410016	descending sigmoid junction	http://purl.obolibrary.org/obo/UBERON_8410024	intestinal junction		The anatomical junction between the descending colon and the sigmoid colon.
http://purl.obolibrary.org/obo/UBERON_8410017	left colic vein	http://purl.obolibrary.org/obo/UBERON_0002017	portal vein		A portal vein that drains the descending colon. It is a tributary of the inferior mesenteric vein, and follows the path of its corresponding artery, the left colic artery.
http://purl.obolibrary.org/obo/UBERON_8410019	jejuno-ileal junction	http://purl.obolibrary.org/obo/UBERON_8410024	intestinal junction		The area where the jejunum ends and the ileum part of the intestine begins. Although there is no clear distinct section, the ileum is narrower and has smaller villi than the jejunum.
http://purl.obolibrary.org/obo/UBERON_8410033	lymph node vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein where lymph node venules condense and which exits at the lymph node hilum. It is also called hilar vein.
http://purl.obolibrary.org/obo/UBERON_8410034	lymph node artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		An artery that enters the lymph node at the hilum and branches into smaller arterioles.
http://purl.obolibrary.org/obo/CHEBI_167559	glycan	http://purl.obolibrary.org/obo/CHEBI_78616	carbohydrates and carbohydrate derivatives		Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also <a href="http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001" target="_blank">http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001</a>.
http://purl.obolibrary.org/obo/PATO_0070002	basket cell morphology	http://purl.obolibrary.org/obo/PATO_0070026	multipolar neuron morphology		A cell morphology that inheres in multipolar neurons with densely branched terminal axonal arborizations that form basket-like structures surrounding and synapsing to the somas of target cells.
http://purl.obolibrary.org/obo/PATO_0070025	unipolar neuron morphology	http://purl.obolibrary.org/obo/PATO_0010006	cell morphology		A cell morphology that inheres in neurons with only one process, a neurite, that extends from the cell body. The neurite then branches to form dendritic and axonal processes.
http://purl.obolibrary.org/obo/PATO_0070026	multipolar neuron morphology	http://purl.obolibrary.org/obo/PATO_0010006	cell morphology		A cell morphology that inheres in neurons which possess three or more neurites, usually a single axon and many dendrites and dendritic branches.
http://purl.obolibrary.org/obo/CL_4023154	myelinating glial cell	http://purl.obolibrary.org/obo/CL_0000125	glial cell		A glial cell that myelinates axonal processes.
http://purl.obolibrary.org/obo/HP_5200230	Maladaptive fear-related cognitions	http://purl.obolibrary.org/obo/HP_5200401	Abnormal judgment		Threat-based cognitive biases result in a skewed perception, experience, or processing of internal or external stimuli.
http://purl.obolibrary.org/obo/HP_5200232	Phobia	http://purl.obolibrary.org/obo/HP_5200230	Maladaptive fear-related cognitions		Extreme, irrational, and persistent fears of certain objects, situations, activities, or persons can impede functioning in day-to-day life.
http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		A repeating behavior that is either immediately unproductive or has negative long-term consequences. This includes harmful coping mechanisms such as addictive behavior and failure to control impulses and compulsions.
http://purl.obolibrary.org/obo/HP_5200296	Abnormal transition from sleep to wakefulness	http://purl.obolibrary.org/obo/HP_5200293	Sleep-wake transition abnormality		Abnormal transition of consciousness from sleeping to wakefulness.
http://purl.obolibrary.org/obo/HP_5200401	Abnormal judgment	http://purl.obolibrary.org/obo/HP_5200423	Abnormal experience of reality		Beliefs that deviate from what is considered rational or within the range of normal human judgment and belief formation.
http://purl.obolibrary.org/obo/HP_5200423	Abnormal experience of reality	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		Subjective phenomena or perceptions that deviate from what is considered correct or are outside the range of normal human experiences.
http://purl.obolibrary.org/obo/HP_5200430	Abnormal psychotic pattern	http://purl.obolibrary.org/obo/HP_5200423	Abnormal experience of reality		Any abnormal pattern of psychotic experiences, where an individual has significant disturbances in their thoughts, perceptions, emotions, and behavior, resulting in a loss of touch with reality.
http://purl.obolibrary.org/obo/CHEBI_232436	calcium chelator	http://purl.obolibrary.org/obo/CHEBI_38161	chelator		A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central calcium atom at two or more points.
http://purl.obolibrary.org/obo/HP_6001115	EEG with temporal slowing	http://purl.obolibrary.org/obo/HP_0010843	EEG with focal slow activity		Slow-wave activity observed in the temporal area of the scalp electro-encephalogram (EEG).
http://purl.obolibrary.org/obo/HP_6001116	History of high-pressure injection injury of the hand	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Medical history of the hand having come into contact with the nozzle of a high-pressure injecting system such as a paint gun or air compressor.
http://purl.obolibrary.org/obo/HP_6001117	Hypertrophic ulnar styloid process	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		Excessively long styloid process of the ulna.
http://purl.obolibrary.org/obo/HP_6001118	History of recent peripheral venous catheter	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A history of placement of a peripehral venous catheter in the hours, days, or weeks before the current presenting complaint.
http://purl.obolibrary.org/obo/HP_6001119	Purulent drainage from skin	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Exudation of a thick, opaque fluid from a wound or skin lesion, typically as a result of infection and draining pus, i.e., dead white blood cells, bacteria, and tissue debris.
http://purl.obolibrary.org/obo/HP_6001120	Occupational history of putting fingers in other people's mouths	http://purl.obolibrary.org/obo/HP_0035010	Occupational exposure history		A history of exposure of fingers by putting them in other peoples' mouths occupationally, e.g., as a dentist or physician.
http://purl.obolibrary.org/obo/HP_6001121	Single-finger involvement	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance are limited to or predominantly affect a single finger.
http://purl.obolibrary.org/obo/HP_6001122	Multiple-finger involvement	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance affect more than one finger.
http://purl.obolibrary.org/obo/HP_6001123	Pain disproportionate to abnormality on physical exam	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Exquisite tenderness in a specific region, beyond what one would surmise from examination.
http://purl.obolibrary.org/obo/HP_6001124	Sphenoid wing dysplasia	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		Hypoplasia or aplasia of the greater or lesser wing of the sphenoid bone, typically resulting in widening of the superior orbital fissure, elevation of the [lesser sphenoid wing, and ipsilateral orbital enlargement.
http://purl.obolibrary.org/obo/HP_6001125	Skin laceration	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		An injury in which skin and underlying tissues are cut or torn.
http://purl.obolibrary.org/obo/HP_6001126	Metacarpal fracture	http://purl.obolibrary.org/obo/HP_0004277	Fractured hand bones		A partial or complete breakage of a metacarpal bone.
http://purl.obolibrary.org/obo/HP_6001127	Pain at the base of the thumb	http://purl.obolibrary.org/obo/HP_0046505	Hand pain		An unpleasant sensation characterized by physical discomfort localized to the base of the thumb, over thenar eminence or thumb metacarpal.
http://purl.obolibrary.org/obo/HP_6001128	History of recent participation in athletics	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of participation in sports (football, basketball, soccer, skiing) in the hours, days, or weeks prior to the current presenting complaint.
http://purl.obolibrary.org/obo/HP_6001129	Remote trauma history	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of trauma months to years ago, including but not limited to fracture or other orthopedic injury at the symptomatic area.
http://purl.obolibrary.org/obo/HP_6001130	Distal radioulnar joint arthritis	http://purl.obolibrary.org/obo/HP_0003059	Abnormality of the radioulnar joints		An inflammatory condition of the joint that connects the far ends of the radius and the ulna, known as the distal radioulnar joint (DRUJ). DRUJ arthritis may be characterized by widening of the DRUJ interval, volar/dorsal displacement of the distal ulna, radiographic evidence of osteoarthritis at the DRUJ joint including osteophytes, subchondral cysts, subchrondal sclerosis, and joint space narrowing.
http://purl.obolibrary.org/obo/HP_6001131	Radial head fracture	http://purl.obolibrary.org/obo/HP_0003978	Fractured radius		Fracture of the proximal end of the radius involving the radial head.
http://purl.obolibrary.org/obo/HP_6001132	Elbow lateral collateral ligament tear	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		An injury to the lateral collateral ligament (LCL) of the elbow. The LCL is a complex capsuloligamentous structure critical in stabilizing the ulnohumeral and radiocapitellar articulations. LCL injury can result in elbow instability, allowing the proximal radius and ulna to externally rotate away from the humerus as a supination stress is applied to the forearm.
http://purl.obolibrary.org/obo/HP_6001133	Elbow medial collateral ligament tear	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		An injury to the medial collateral ligament (MCL) of the elbow.
http://purl.obolibrary.org/obo/HP_6001134	Coronoid fracture	http://purl.obolibrary.org/obo/HP_0003987	Fractured ulna		Fracture of the coronoid process on the proximal ulna.
http://purl.obolibrary.org/obo/HP_6001135	History of spinal cord injury	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A medical history of hving had a spinal cord injury prior to the presenting complaint.
http://purl.obolibrary.org/obo/HP_6001136	Femoral nerve distribution	http://purl.obolibrary.org/obo/HP_0025849	Localized along nerve distribution		Paresthesias in anterior/medial aspect of the thigh (anterior and medial cutaneous nerves of the thigh) and/or medial aspect of the lower leg and foot (saphenous distribution). May be accompanied by weakness in the quadriceps.
http://purl.obolibrary.org/obo/HP_6001137	Triceps tendon rupture	http://purl.obolibrary.org/obo/HP_0100550	Tendon rupture		Breakage (tear) of the triceps tendon.
http://purl.obolibrary.org/obo/HP_6001138	Digoxin exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treateed with digoxin.
http://purl.obolibrary.org/obo/HP_6001139	Upper arm pain	http://purl.obolibrary.org/obo/HP_0012513	Upper limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the upper arm.
http://purl.obolibrary.org/obo/HP_6001140	Capitellum fracture	http://purl.obolibrary.org/obo/HP_0041055	Fractured humerus		A partial or complete breakage of the capitulum of the humerus, which is a smooth, rounded eminence on the lateral portion of the distal articular surface of the humerus.
http://purl.obolibrary.org/obo/HP_6001141	Anterior shoulder pain	http://purl.obolibrary.org/obo/HP_0030834	Shoulder pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the anterior (front) part of the shoulder.
http://purl.obolibrary.org/obo/HP_6001142	Pain at the anterior aspect of the elbow	http://purl.obolibrary.org/obo/HP_0030835	Elbow pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the front part of the elbow front part of the elbow, that is, on the ventral side of the arm where the arm bends.
http://purl.obolibrary.org/obo/HP_6001143	Posterior fat pad sign of the elbow	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		Lateral elbow x-ray showing lucent crescent of fat that indicates a joint effusion in the elbow .
http://purl.obolibrary.org/obo/HP_6001144	Pain at the anterior aspect of the knee	http://purl.obolibrary.org/obo/HP_0030839	Knee pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the front part of the knee, that is, the side of the knee where the patella is located.
http://purl.obolibrary.org/obo/HP_6001145	Pain at the posterior aspect of the knee	http://purl.obolibrary.org/obo/HP_0030839	Knee pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back part of the knee, that is, opposite to the side of the knee where the patella is located.
http://purl.obolibrary.org/obo/HP_6001146	Biceps tendonitis	http://purl.obolibrary.org/obo/HP_0025230	Tendonitis		Biceps tendinitis is inflammation of the tendon around the long head of the biceps muscle.
http://purl.obolibrary.org/obo/HP_6001147	Increased peripheral nerve cross sectional area	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Ultrasonography showing increased cross sectional area (CSA) of a peripheral nerve as it travels through a potential site of compression.
http://purl.obolibrary.org/obo/HP_6001148	Pain exacerbated by passive flexion at joint	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Pain in extremity that worsens with joint is passively flexed.
http://purl.obolibrary.org/obo/HP_6001149	Positive hook test at the elbow	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		With forearm fully supinated and elbow flexed to 90 degrees, examiner hooks a finger a bit around the distal biceps tendon at the anterior aspect of the elbow. Test is positive when there is lack of appreciable cord like structure to hook around.
http://purl.obolibrary.org/obo/HP_6001150	Positive Speed's test	http://purl.obolibrary.org/obo/HP_0025823	Positive provocative functional shoulder test		Manual downward pressure on the arm with the shoulders flexed forward to 90 degrees, elbows fully extended, and palm facing up recreates pain in the anterior shoulder region; named after Dr. Speed.
http://purl.obolibrary.org/obo/HP_6001151	Triangular lunate bone	http://purl.obolibrary.org/obo/HP_0004248	Abnormal lunate bone morphology		A disruption of the greater and lesser arcs of the lunate bone, with the lunate having a triangular silhouette, know as the piece of pie sign. Often caused by falling on an outstretched hand, patients will have tenderness to palpation over the dorsum of the wrist and may have sensory deficits in the median nerve distribution.
http://purl.obolibrary.org/obo/HP_6001152	Pain exacerbated by wrist deviation	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Pain worsens with wrist ulnar or radial deviation.
http://purl.obolibrary.org/obo/HP_6001153	Pain on the lateral aspect of the foot	http://purl.obolibrary.org/obo/HP_0025238	Foot pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the side of the foot nearest to the little (fifth) toe.
http://purl.obolibrary.org/obo/HP_6001154	Pain at the medial aspect of the knee	http://purl.obolibrary.org/obo/HP_0030839	Knee pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the inner side of knee, that is, the region of the knee that faces the other knee.
http://purl.obolibrary.org/obo/HP_6001155	Pain at the lateral aspect of the knee	http://purl.obolibrary.org/obo/HP_0030839	Knee pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the outer side of knee, that is, the region of the knee that faces away from the other knee.
http://purl.obolibrary.org/obo/CHEBI_747204	reference compound	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		Any well-characterized compound that serves as a standard for the identification, quantification, calibration, or quality control of substances in scientific analysis.
http://purl.obolibrary.org/obo/CHEBI_10545	electron	http://purl.obolibrary.org/obo/CHEBI_36338	lepton		Elementary particle not affected by the strong force having a spin ½, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.
http://purl.obolibrary.org/obo/CHEBI_15414	S-adenosyl-L-methionine	http://purl.obolibrary.org/obo/CHEBI_26830	sulfonium compound		A sulfonium compound that is the <em>S</em>-adenosyl derivative of <small>L</small>-methionine. It is an intermediate in the metabolic pathway of methionine.
http://purl.obolibrary.org/obo/CHEBI_15428	glycine	http://purl.obolibrary.org/obo/CHEBI_83813	proteinogenic amino acid		The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.
http://purl.obolibrary.org/obo/CHEBI_15440	squalene	http://purl.obolibrary.org/obo/CHEBI_35191	triterpene		A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (<em>all-E</em>)-configuration.
http://purl.obolibrary.org/obo/CHEBI_15734	primary alcohol	http://purl.obolibrary.org/obo/CHEBI_30879	alcohol		A primary alcohol is a compound in which a hydroxy group, ‒OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
http://purl.obolibrary.org/obo/CHEBI_17478	aldehyde	http://purl.obolibrary.org/obo/CHEBI_36586	carbonyl compound		A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
http://purl.obolibrary.org/obo/CHEBI_18095	trans-4-hydroxy-L-proline	http://purl.obolibrary.org/obo/CHEBI_20392	4-hydroxyproline		An optically active form of 4-hydroxyproline having <small>L</small>-<i>trans</i>-configuration.
http://purl.obolibrary.org/obo/CHEBI_24315	glutamic acid derivative	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		An amino acid derivative resulting from reaction of glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing glutamic acid residues.
http://purl.obolibrary.org/obo/CHEBI_24400	glycoside	http://purl.obolibrary.org/obo/CHEBI_63161	glycosyl compound		A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO‒, RS‒, RSe‒, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms <em>N</em>-glycosides and <em>C</em>-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and <em>C</em>-glycosyl compounds, respectively.
http://purl.obolibrary.org/obo/CHEBI_24436	guanidines	http://purl.obolibrary.org/obo/CHEBI_35352	organonitrogen compound		Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R<small><sup>1</small></sup>R<small><sup>2</small></sup>N)(R<small><sup>3</small></sup>R<small><sup>4</small></sup>N)C=N-R<small><sup>5</small></sup> and are related structurally to amidines and ureas.
http://purl.obolibrary.org/obo/CHEBI_24963	ketoaldonic acid	http://purl.obolibrary.org/obo/CHEBI_35381	monosaccharide		Oxo carboxylic acids formally derived from aldonic acids by replacement of a secondary CHOH group by a carbonyl group.
http://purl.obolibrary.org/obo/CHEBI_25481	naphthoquinone	http://purl.obolibrary.org/obo/CHEBI_36141	quinone		A polycyclic aromatic ketone metabolite of naphthalene.
http://purl.obolibrary.org/obo/CHEBI_25754	oxo carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_33575	carboxylic acid		Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule.
http://purl.obolibrary.org/obo/CHEBI_33286	agrochemical	http://purl.obolibrary.org/obo/CHEBI_33232	application		An agrochemical is a substance that is used in agriculture or horticulture.
http://purl.obolibrary.org/obo/CHEBI_35910	2-oxo monocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_35871	oxo monocarboxylic acid		Any monocarboxylic acid having a 2-oxo substituent.
http://purl.obolibrary.org/obo/CHEBI_35931	delta-amino acid	http://purl.obolibrary.org/obo/CHEBI_83820	non-proteinogenic amino acid		A non-proteinogenic amino acid in which the amino group is located on the carbon atom at the position δ to the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_36338	lepton	http://purl.obolibrary.org/obo/CHEBI_36340	fermion		Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek λεπτοσ (small, thin).
http://purl.obolibrary.org/obo/CHEBI_38337	pyrimidone	http://purl.obolibrary.org/obo/CHEBI_39447	pyrimidines		A pyrimidine carrying one or more oxo substituents.
http://purl.obolibrary.org/obo/CHEBI_38975	methylbenzene	http://purl.obolibrary.org/obo/CHEBI_38976	alkylbenzene		Any alkylbenzene that is benzene substituted with one or more methyl groups.
http://purl.obolibrary.org/obo/CHEBI_50401	cholestanoid	http://purl.obolibrary.org/obo/CHEBI_35341	steroid		Any steroid based on a cholestane skeleton and its derivatives.
http://purl.obolibrary.org/obo/CHEBI_77746	human metabolite	http://purl.obolibrary.org/obo/CHEBI_75768	mammalian metabolite		Any mammalian metabolite  produced during a metabolic reaction in humans (<em>Homo sapiens</em>).
http://purl.obolibrary.org/obo/CHEBI_78574	pyrimidinecarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_39447	pyrimidines		Any pyrimidine that bears one or more carboxylic acid substituents.
http://purl.obolibrary.org/obo/CHEBI_83822	non-proteinogenic L-alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		Any <small>L</small>-α-amino acid which is not a member of the group of 23 proteinogenic amino acids.
http://purl.obolibrary.org/obo/CHEBI_11851	3-methyl-2-oxobutanoate	http://purl.obolibrary.org/obo/CHEBI_191201	branched-chain keto acid anion		A 2-oxo monocarboxylic acid anion that is the conjugate base of 3-methyl-2-oxobutanoic acid, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_16385	organic sulfide	http://purl.obolibrary.org/obo/CHEBI_26822	sulfide		Compounds having the structure RSR (R ≠ H). Such compounds were once called thioethers.
http://purl.obolibrary.org/obo/CHEBI_16530	3-methyl-2-oxobutanoic acid	http://purl.obolibrary.org/obo/CHEBI_191197	branched-chain keto acid		A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid.
http://purl.obolibrary.org/obo/CHEBI_17272	propionate	http://purl.obolibrary.org/obo/CHEBI_78113	fatty acid anion 3:0		The conjugate base of propionic acid; a key precursor in lipid biosynthesis.
http://purl.obolibrary.org/obo/CHEBI_17325	3-hydroxy-3-methylglutarate(2-)	http://purl.obolibrary.org/obo/CHEBI_133251	3-hydroxydicarboxylate(2-)		A dicarboxylic acid dianion that results from the removal of a proton from both of the carboxylic acid groups of 3-hydroxy-3-methylglutaric acid.
http://purl.obolibrary.org/obo/CHEBI_17612	(3,4-dihydroxyphenyl)acetate	http://purl.obolibrary.org/obo/CHEBI_36059	hydroxy monocarboxylic acid anion		A dihydroxy monocarboxylic acid anion that is the conjugate base of (3,4-dihydroxyphenyl)acetic acid, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_17754	glycerol	http://purl.obolibrary.org/obo/CHEBI_17522	alditol		A triol with a structure of propane substituted at positions 1, 2 and 3 by hydroxy groups.
http://purl.obolibrary.org/obo/CHEBI_18258	3,3',5-triiodo-L-thyronine	http://purl.obolibrary.org/obo/CHEBI_24864	iodothyronine		An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-<small>L</small>-thyronine in the body is generated by mono-deiodination of <small>L</small>-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of <small>L</small>-thyroxine. The sodium salt is used in the treatment of hypothyroidism.
http://purl.obolibrary.org/obo/CHEBI_19168	17-oxo steroid	http://purl.obolibrary.org/obo/CHEBI_3992	cyclic ketone		Any  oxo steroid carrying the oxo group at position 17.
http://purl.obolibrary.org/obo/CHEBI_22860	amino-acid betaine	http://purl.obolibrary.org/obo/CHEBI_83821	amino-acid derivative		Any amino acid-derived zwitterion - such as glycine betaine (<em>N</em>,<em>N</em>,<em>N</em>-trimethylammonioacetate) - in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms.
http://purl.obolibrary.org/obo/CHEBI_26148	piperidinemonocarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_26151	piperidines		Any member of the class of piperidines in which one of the carbons of the piperidine ring is substituted by a carboxy group.
http://purl.obolibrary.org/obo/CHEBI_28689	dehydroepiandrosterone	http://purl.obolibrary.org/obo/CHEBI_19168	17-oxo steroid		An androstanoid that is androst-5-ene substituted by a β-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
http://purl.obolibrary.org/obo/CHEBI_28866	tetracosanoic acid	http://purl.obolibrary.org/obo/CHEBI_39418	straight-chain saturated fatty acid		A C<small><sub>24</sub></small> straight-chain saturated fatty acid.
http://purl.obolibrary.org/obo/CHEBI_31009	hexacosanoic acid	http://purl.obolibrary.org/obo/CHEBI_191874	fatty acid 26:0		A 26-carbon, straight-chain, saturated fatty acid.
http://purl.obolibrary.org/obo/CHEBI_36242	3-(4-hydroxyphenyl)pyruvate	http://purl.obolibrary.org/obo/CHEBI_35179	2-oxo monocarboxylic acid anion		A 2-oxo monocarboxylic acid anion obtained by removal of a proton from the carboxylic acid group of 3-(4-hydroxyphenyl)pyruvic acid.
http://purl.obolibrary.org/obo/CHEBI_58955	branched-chain fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		Any fatty acid anion with a carbon side-chain or isopropyl termination.
http://purl.obolibrary.org/obo/CHEBI_59836	oxo fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		A fatty acid anion carrying one or more oxo substituents
http://purl.obolibrary.org/obo/CHEBI_78804	Caenorhabditis elegans metabolite	http://purl.obolibrary.org/obo/CHEBI_78803	nematode metabolite		A nematode metabolite produced by <em>Caenorhabditis elegans</em>.
http://purl.obolibrary.org/obo/CHEBI_84186	L-proline derivative	http://purl.obolibrary.org/obo/CHEBI_26273	proline derivative		A proteinogenic amino acid derivative resulting from reaction of <small>L</small>-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of <small>L</small>-proline  by a heteroatom.
http://purl.obolibrary.org/obo/CHEBI_16024	D-mannose	http://purl.obolibrary.org/obo/CHEBI_17608	D-aldohexose		A mannose with <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_16113	cholesterol	http://purl.obolibrary.org/obo/CHEBI_35348	3beta-sterol		A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3β-hydroxy group.
http://purl.obolibrary.org/obo/CHEBI_16313	D-proline	http://purl.obolibrary.org/obo/CHEBI_26271	proline		The <small>D</small>-enantiomer of proline.
http://purl.obolibrary.org/obo/CHEBI_16375	D-cysteine	http://purl.obolibrary.org/obo/CHEBI_16733	D-alpha-amino acid		An optically active form of cysteine having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_16867	D-methionine	http://purl.obolibrary.org/obo/CHEBI_16733	D-alpha-amino acid		An optically active form of methionine having <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_16988	D-ribose	http://purl.obolibrary.org/obo/CHEBI_33942	ribose		A ribose in which the chiral carbon atom furthest away from the aldehyde group (C4') has the same configuration as in <small>D</small>-glyceraldehyde.
http://purl.obolibrary.org/obo/CHEBI_17044	D-glucitol 6-phosphate	http://purl.obolibrary.org/obo/CHEBI_35375	alditol 6-phosphate		The 6-<em>O</em>-phospho derivative of <small>D</small>-glucitol.
http://purl.obolibrary.org/obo/CHEBI_17196	L-asparagine	http://purl.obolibrary.org/obo/CHEBI_22653	asparagine		An optically active form of asparagine having <small>L</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_17608	D-aldohexose	http://purl.obolibrary.org/obo/CHEBI_4194	D-hexose		Any <small>D</small>-aldose having a chain of six carbon atoms in the molecule.
http://purl.obolibrary.org/obo/CHEBI_17634	D-glucose	http://purl.obolibrary.org/obo/CHEBI_17608	D-aldohexose		A glucose with <small>D</small>-configuration.
http://purl.obolibrary.org/obo/CHEBI_17924	D-glucitol	http://purl.obolibrary.org/obo/CHEBI_30911	glucitol		The <small>D</small>-enantiomer of glucitol (also known as <small>D</small>-sorbitol).
http://purl.obolibrary.org/obo/CHEBI_18254	ribonucleoside	http://purl.obolibrary.org/obo/CHEBI_47019	dihydroxytetrahydrofuran		Any nucleoside where the sugar component is <small>D</small>-ribose.
http://purl.obolibrary.org/obo/CHEBI_23899	icosanoid	http://purl.obolibrary.org/obo/CHEBI_61697	fatty acid derivative		Any member of the group of signalling molecules arising from oxidation of the three C<small><sub>20</sub></small> essential fatty acids (EFAs) icosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA).
http://purl.obolibrary.org/obo/CHEBI_26208	polyunsaturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_27208	unsaturated fatty acid		Any fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome.
http://purl.obolibrary.org/obo/CHEBI_28260	galactose	http://purl.obolibrary.org/obo/CHEBI_33917	aldohexose		An aldohexose that is the C-4 epimer of glucose.
http://purl.obolibrary.org/obo/CHEBI_29986	D-glutamate(1-)	http://purl.obolibrary.org/obo/CHEBI_14321	glutamate(1-)		An α-amino-acid anion that is the conjugate base of <small>D</small>-glutamic acid, having anionic carboxy groups and a cationic amino group
http://purl.obolibrary.org/obo/CHEBI_29990	D-aspartate(1-)	http://purl.obolibrary.org/obo/CHEBI_35391	aspartate(1-)		An aspartate(1−) that is the conjugate base of <small>D</small>-aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_29991	L-aspartate(1-)	http://purl.obolibrary.org/obo/CHEBI_62031	polar amino acid zwitterion		An aspartate(1−) that is the  conjugate base of <small>L</small>-aspartic acid.
http://purl.obolibrary.org/obo/CHEBI_35348	3beta-sterol	http://purl.obolibrary.org/obo/CHEBI_36836	3beta-hydroxy steroid		A sterol in which the hydroxy group at position 3 has β- configuration.
http://purl.obolibrary.org/obo/CHEBI_37142	organoiodine compound	http://purl.obolibrary.org/obo/CHEBI_17792	organohalogen compound		An organoiodine compound is a compound containing at least one carbon-iodine bond.
http://purl.obolibrary.org/obo/CHEBI_37712	O-phosphoserine	http://purl.obolibrary.org/obo/CHEBI_83925	non-proteinogenic alpha-amino acid		A serine derivative that is serine substituted at the oxygen atom by a phosphono group.
http://purl.obolibrary.org/obo/CHEBI_48706	antagonist	http://purl.obolibrary.org/obo/CHEBI_52210	pharmacological role		Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.
http://purl.obolibrary.org/obo/CHEBI_26836	sulfuric acid	http://purl.obolibrary.org/obo/CHEBI_33402	sulfur oxoacid		A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.
http://purl.obolibrary.org/obo/CHEBI_26977	thiosulfate	http://purl.obolibrary.org/obo/CHEBI_37827	thiosulfuric acid derivative		An ester of thiosulfuric acid.
http://purl.obolibrary.org/obo/CHEBI_26995	thromboxane	http://purl.obolibrary.org/obo/CHEBI_26347	prostanoid		A class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels.
http://purl.obolibrary.org/obo/CHEBI_27081	transition element atom	http://purl.obolibrary.org/obo/CHEBI_33521	metal atom		An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell.
http://purl.obolibrary.org/obo/CHEBI_27248	urocanic acid	http://purl.obolibrary.org/obo/CHEBI_79020	alpha,beta-unsaturated monocarboxylic acid		An α,β-unsaturated monocarboxylic acid that is prop-2-enoic acid substituted by a 1<em>H</em>-imidazol-4-yl group at position 3. It is a metabolite of hidtidine.
http://purl.obolibrary.org/obo/CHEBI_32504	phenylalaninate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An aromatic amino-acid anion that is the conjugate base of phenylalanine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32505	phenylalaninium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of phenylalanine, arising from protonation of the amino group.
http://purl.obolibrary.org/obo/CHEBI_32678	glutaminate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of glutamine, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32679	glutaminium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of glutamine, arising from protonation of the amino group.
http://purl.obolibrary.org/obo/CHEBI_32727	tryptophanate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of tryptophan, arising from deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/CHEBI_32728	tryptophanium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		An α-amino-acid cation that is the conjugate acid of tryptophan, arising from protonation of the α-amino group.
http://purl.obolibrary.org/obo/CHEBI_33234	vitamin E	http://purl.obolibrary.org/obo/CHEBI_23229	chromanol		Any member of a group of fat-soluble chromanols  that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
http://purl.obolibrary.org/obo/CHEBI_33672	heterobicyclic compound	http://purl.obolibrary.org/obo/CHEBI_33636	bicyclic compound		A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.
http://purl.obolibrary.org/obo/CHEBI_35186	terpene	http://purl.obolibrary.org/obo/CHEBI_24632	hydrocarbon		A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH<small><sub>2</sub></small>=C(CH<small><sub>3</sub></small>)CH=CH<small><sub>2</sub></small>].
http://purl.obolibrary.org/obo/CHEBI_35842	antirheumatic drug	http://purl.obolibrary.org/obo/CHEBI_23888	drug		A drug used to treat rheumatoid arthritis.
http://purl.obolibrary.org/obo/CHEBI_37996	organic thiosulfate	http://purl.obolibrary.org/obo/CHEBI_26977	thiosulfate		The organic ester of thiosulfuric acid.
http://purl.obolibrary.org/obo/CHEBI_38077	polypyrrole	http://purl.obolibrary.org/obo/CHEBI_38101	organonitrogen heterocyclic compound		A compound composed of two or more pyrrole units.
http://purl.obolibrary.org/obo/CHEBI_38263	2-amino-3-hydroxybutanoic acid	http://purl.obolibrary.org/obo/CHEBI_33704	alpha-amino acid		An α-amino acid that is butanoic acid substituted by an amino group at position 2 and a hydroxy group at position 3.
http://purl.obolibrary.org/obo/CHEBI_38323	cholinergic drug	http://purl.obolibrary.org/obo/CHEBI_35942	neurotransmitter agent		Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.
http://purl.obolibrary.org/obo/CHEBI_38653	methylbutyric acid	http://purl.obolibrary.org/obo/CHEBI_62499	methyl-branched fatty acid		A methyl-branched fatty acid comprising a butyric acid core carrying a single methyl substituent.
http://purl.obolibrary.org/obo/CHEBI_38717	carboxylic acid trianion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A trianion containing at least one carboxy group.
http://purl.obolibrary.org/obo/CHEBI_46818	urate anion	http://purl.obolibrary.org/obo/CHEBI_25696	organic anion		An organic anion obtained by removal of at least one proton from any uric acid.
http://purl.obolibrary.org/obo/CHEBI_48942	isovalerate	http://purl.obolibrary.org/obo/CHEBI_58956	branched-chain saturated fatty acid anion		A branched-chain saturated fatty acid anion that is the conjugate base of isovaleric acid; reported to improve ruminal fermentation and feed digestion in cattle.
http://purl.obolibrary.org/obo/CHEBI_50188	provitamin	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A substance that can be converted into a vitamin by animal tissues.
http://purl.obolibrary.org/obo/CHEBI_51151	dipolar compound	http://purl.obolibrary.org/obo/CHEBI_72695	organic molecule		An  organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case.
http://purl.obolibrary.org/obo/CHEBI_52303	sterol methyltransferase inhibitor	http://purl.obolibrary.org/obo/CHEBI_76871	EC 2.1.1.* (methyltransferases) inhibitor		An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of sterol methyltransferase.
http://purl.obolibrary.org/obo/CHEBI_58950	very long-chain fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		Any fatty acid anion with a chain length greater than C<small><sub>22</sub></small>.
http://purl.obolibrary.org/obo/CHEBI_62225	S-sulfo-L-cysteinate(1-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the conjugate base of <em>S</em>-sulfo-<small>L</small>-cysteine; major species ar pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_62501	folate(2-)	http://purl.obolibrary.org/obo/CHEBI_67011	folates		The dicarboxylic acid dianion formed from folic acid by loss of a proton from each of the two carboxy groups in the glutamic acid moiety.
http://purl.obolibrary.org/obo/CHEBI_62945	thromboxane anion	http://purl.obolibrary.org/obo/CHEBI_62943	prostanoid anion		A prostanoid anion that is the conjugate base of a thromboxane.
http://purl.obolibrary.org/obo/CHEBI_63470	sulfur-containing amino-acid anion	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		A sulfur-containing amino acid whose α-carboxylic acid group is ionized (not protonated).
http://purl.obolibrary.org/obo/CHEBI_64047	food additive	http://purl.obolibrary.org/obo/CHEBI_78295	food component		Any substance which is added to food to preserve or enhance its flavour and/or appearance.
http://purl.obolibrary.org/obo/CHEBI_64554	tryptophan zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of tryptophan; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_74337	D-asparagine zwitterion	http://purl.obolibrary.org/obo/CHEBI_59871	D-alpha-amino acid zwitterion		A <small>D</small>-α-amino acid zwitterion that is <small>D</small>-asparagine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_78118	fatty acid anion 10:0	http://purl.obolibrary.org/obo/CHEBI_58953	saturated fatty acid anion		Any saturated fatty acid anion containing 10 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_83146	Daphnia tenebrosa metabolite	http://purl.obolibrary.org/obo/CHEBI_83057	Daphnia metabolite		A <em>Daphnia</em> metabolite produced by the species <em>Daphnia tenebrosa</em>.
http://purl.obolibrary.org/obo/CHEBI_88184	metal allergen	http://purl.obolibrary.org/obo/CHEBI_33521	metal atom		Any metal which causes the onset of an allergic reaction.
http://purl.obolibrary.org/obo/CHEBI_35137	hemoprotein	http://purl.obolibrary.org/obo/CHEBI_35136	iron protein		Conjugated proteins containing heme as the prosthetic group.
http://purl.obolibrary.org/obo/CHEBI_35281	onium betaine	http://purl.obolibrary.org/obo/CHEBI_27369	zwitterion		Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.
http://purl.obolibrary.org/obo/CHEBI_35568	mancude ring	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds.
http://purl.obolibrary.org/obo/CHEBI_36237	cholanic acid	http://purl.obolibrary.org/obo/CHEBI_36278	cholanic acids		A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24.
http://purl.obolibrary.org/obo/CHEBI_36340	fermion	http://purl.obolibrary.org/obo/CHEBI_36342	subatomic particle		Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi.
http://purl.obolibrary.org/obo/CHEBI_36343	composite particle	http://purl.obolibrary.org/obo/CHEBI_36342	subatomic particle		A subatomic particle known to have substructure (i.e. consisting of smaller particles).
http://purl.obolibrary.org/obo/CHEBI_36344	hadron	http://purl.obolibrary.org/obo/CHEBI_36343	composite particle		Hadron is a subatomic particle which experiences the strong force.
http://purl.obolibrary.org/obo/CHEBI_36606	acid anhydride	http://purl.obolibrary.org/obo/CHEBI_50860	organic molecular entity		Compounds consisting of two acyl groups bonded to the same oxygen atom acyl‒O‒acyl.
http://purl.obolibrary.org/obo/CHEBI_36756	farnesane	http://purl.obolibrary.org/obo/CHEBI_35189	sesquiterpene		A sesquiterpene that is dodecane substituted by methyl groups at positions 2, 6 and 10.
http://purl.obolibrary.org/obo/CHEBI_48343	disulfide	http://purl.obolibrary.org/obo/CHEBI_26835	sulfur molecular entity		Compounds of structure RSSR'.
http://purl.obolibrary.org/obo/CHEBI_48540	beta-adrenergic drug	http://purl.obolibrary.org/obo/CHEBI_37962	adrenergic agent		Any of the drugs that act on β-adrenergic receptors.
http://purl.obolibrary.org/obo/CHEBI_52210	pharmacological role	http://purl.obolibrary.org/obo/CHEBI_24432	biological role		A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
http://purl.obolibrary.org/obo/CHEBI_59238	cyclic fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid containing anywhere in its structure a ring of atoms.
http://purl.obolibrary.org/obo/CHEBI_63046	emulsifier	http://purl.obolibrary.org/obo/CHEBI_51086	chemical role		The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability.
http://purl.obolibrary.org/obo/CHEBI_63790	glyco-amino-acid anion	http://purl.obolibrary.org/obo/CHEBI_37022	amino-acid anion		The amino-acid anion formed by proton loss from the carboxylic acid function of a glyco-amino acid.
http://purl.obolibrary.org/obo/CHEBI_76835	EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76726	EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor		An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD<small><sup>+</small></sup> or NADP<small><sup>+</small></sup> as acceptor (EC 1.1.1.*).
http://purl.obolibrary.org/obo/CHEBI_77450	dicarboxylic acid monoamide(1-)	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any dicarboxylic acid monoamide; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_86508	alpha-aminobutyrate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		An α-amino-acid anion that is the  conjugate base of α-aminobutyric acid.
http://purl.obolibrary.org/obo/CHEBI_545959	homovanillic acid	http://purl.obolibrary.org/obo/CHEBI_25384	monocarboxylic acid		A monocarboxylic acid that is the 3-<em>O</em>-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.
http://purl.obolibrary.org/obo/CHEBI_5520	gonadorelin	http://purl.obolibrary.org/obo/CHEBI_25905	peptide hormone		A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence.
http://purl.obolibrary.org/obo/CHEBI_63533	gonadotropin releasing hormone agonist	http://purl.obolibrary.org/obo/CHEBI_51060	hormone agonist		Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response.
http://purl.obolibrary.org/obo/CHEBI_66884	N-alkylglycine zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238	amino-acid zwitterion		An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of any <em>N</em>-alkylglycine; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_77225	all-cis-docosa-7,10,13,16-tetraenoate	http://purl.obolibrary.org/obo/CHEBI_57560	long-chain fatty acid anion		A polyunsaturated fatty acid anion that is the conjugate base of <i>all</i>-<i>cis</i>-docosa-7,10,13,16-tetraenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_64766	cationic group	http://purl.obolibrary.org/obo/CHEBI_24433	group		A group that carries an overall positive charge.
http://purl.obolibrary.org/obo/CHEBI_64767	anionic group	http://purl.obolibrary.org/obo/CHEBI_24433	group		A group that carries an overall negative charge.
http://purl.obolibrary.org/obo/CHEBI_64898	anionic amino-acid residue	http://purl.obolibrary.org/obo/CHEBI_64775	organic anionic group		An amino-acid residue carrying an overall negative charge.
http://purl.obolibrary.org/obo/CHEBI_85425	glycine transporter inhibitor	http://purl.obolibrary.org/obo/CHEBI_35222	inhibitor		Any substance that inhibits the action of glycine transporters.
http://purl.obolibrary.org/obo/CHEBI_75603	EC 6.* (ligase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_23924	enzyme inhibitor		Any enzyme inhibitor that interferes with the action of a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
http://purl.obolibrary.org/obo/CHEBI_75604	EC 6.4.* (C-C bond-forming ligase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_75603	EC 6.* (ligase) inhibitor		A ligase inhibitor that interferes with the action of a <em>C</em>‒<em>C</em> bond-forming ligase (EC 6.4.*.*).
http://purl.obolibrary.org/obo/CHEBI_7563	N-nicotinoylglycine	http://purl.obolibrary.org/obo/CHEBI_16180	N-acylglycine		An <em>N</em>-acylglycine having nicotinoyl as the acyl substituent.
http://purl.obolibrary.org/obo/CHEBI_75787	prokaryotic metabolite	http://purl.obolibrary.org/obo/CHEBI_25212	metabolite		Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
http://purl.obolibrary.org/obo/CHEBI_76414	propellant	http://purl.obolibrary.org/obo/CHEBI_33232	application		A compressed gas or liquid with a boiling point lower than room temperature which to used to propel and dispense liquids such as deodorants, insecticides, paints, etc. from aerosol cans.
http://purl.obolibrary.org/obo/CHEBI_76579	triradylglycerol	http://purl.obolibrary.org/obo/CHEBI_35741	glycerolipid		Any glycerolipid that is glycerol bearing three substituent groups - either acyl, alkyl, or alk-1-enyl at each of the three possible positions.
http://purl.obolibrary.org/obo/CHEBI_76619	omega-methyl fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		A fatty acid anion obtained by deprotonation of the carboxy group of any ω-methyl fatty acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_76655	EC 2.1.* (C1-transferase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_71300	EC 2.* (transferase) inhibitor		A transferase inhibitor inhibiting the action of transferase of a one-carbon-containing group (EC 2.1.*.*).
http://purl.obolibrary.org/obo/CHEBI_76710	EC 4.* (lyase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_23924	enzyme inhibitor		An enzyme inhibitor which interferes with the action of a lyase (EC 4.*.*.*). Lyases are enzymes cleaving <em>C</em>‒<em>C</em>, <em>C</em>‒<em>O</em>, <em>C</em>‒<em>N</em> and other bonds by other means than by hydrolysis or oxidation.
http://purl.obolibrary.org/obo/CHEBI_76713	EC 4.3.* (C-N lyase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76710	EC 4.* (lyase) inhibitor		A lyase inhibitor which inhibits the action of a <em>C</em>‒<em>N</em> lyase (EC 4.3.*.*).
http://purl.obolibrary.org/obo/CHEBI_76725	EC 1.* (oxidoreductase) inhibitor	http://purl.obolibrary.org/obo/CHEBI_23924	enzyme inhibitor		An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*).
http://purl.obolibrary.org/obo/CHEBI_76726	EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76725	EC 1.* (oxidoreductase) inhibitor		An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*).
http://purl.obolibrary.org/obo/CHEBI_76764	EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76759	EC 3.* (hydrolase) inhibitor		Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).
http://purl.obolibrary.org/obo/CHEBI_76928	2,3-saturated fatty acid(1-)	http://purl.obolibrary.org/obo/CHEBI_83955	2-saturated fatty acid anion		A fatty acid anion obtained by deprotonation of the carboxy group of any 2,3-saturated fatty acid.
http://purl.obolibrary.org/obo/CHEBI_76929	2,3-saturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any fatty acid in which the first two carbons of the chain attached to the carboxy group are saturated and unbranched.
http://purl.obolibrary.org/obo/CHEBI_83955	2-saturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		A fatty acid anion obtained by deprotonation of the carboxy group of any 2-saturated fatty acid.
http://purl.obolibrary.org/obo/CHEBI_84118	ganglioside GM3	http://purl.obolibrary.org/obo/CHEBI_36544	sialodiosylceramide		A sialodiaosylceramide that is an α-<em>N</em>-acetylneuraminosyl-(2→3)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucosyl-<em>N</em>-acylsphingosine in which the acyl group on nitrogen is (15<i>Z</i>)-tetracos-15-enoyl.
http://purl.obolibrary.org/obo/CHEBI_84125	globoside Gb4	http://purl.obolibrary.org/obo/CHEBI_18259	N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide		A glycotetraosylceramide in which a linear β-<small>D</small>-GalNAc-(1→3)-α-<small>D</small>-Gal-(1→-4)-β-<small>D</small>-Gal-(1→4)-β-<small>D</small>-Glc tetrasaccharide unit is linked glycosidically to a (3<i>R</i>,4<i>E</i>)-3-hydroxy-2-(pentacosanoylamino)octadec-4-en-1-yl ceramide group.
http://purl.obolibrary.org/obo/CHEBI_84690	alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/18:0)	http://purl.obolibrary.org/obo/CHEBI_36508	glycotriaosylceramide		A glycotriaosylceramide having α-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-galactosyl-(1→4)-β-<small>D</small>-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/18:0).
http://purl.obolibrary.org/obo/GO_0120025	plasma membrane bounded cell projection	http://purl.obolibrary.org/obo/GO_0042995	cell projection		A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.
http://purl.obolibrary.org/obo/GO_0098693	regulation of synaptic vesicle cycle	http://purl.obolibrary.org/obo/GO_0060627	regulation of vesicle-mediated transport		Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle.
http://purl.obolibrary.org/obo/HP_0025550	Elevated circulating ribitol concentration	http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration		The concentration of ribitol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/CHEBI_138366	bile acids	http://purl.obolibrary.org/obo/CHEBI_36078	cholanoid		Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5β-configuration, while in lower vertebrates, some bile acids, known as <i>allo</i>-bile acids, have 5α-configuration.
http://purl.obolibrary.org/obo/HP_0025572	Punctal stenosis	http://purl.obolibrary.org/obo/HP_0011479	Abnormal lacrimal punctum morphology		Punctal stenosis is a condition in which the external opening of the lacrimal canaliculus is narrowed or occluded.
http://purl.obolibrary.org/obo/PATO_0045056	normal anterior-posterior diameter	http://purl.obolibrary.org/obo/PATO_0045055	normal diameter		An anterior-posterior diameter which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045026	normal life span	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A life span which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045030	normal mass	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A mass which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045047	normal resistance to	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A resistance to a stimulus which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045007	normal behavioural activity	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A behavioural quality of a process inhering in a bearer by virtue of the bearer's exhibiting normal or average activity.
http://purl.obolibrary.org/obo/PATO_0045054	normal length	http://purl.obolibrary.org/obo/PATO_0045050	normal size		A length quality which is relatively normal or average
http://purl.obolibrary.org/obo/GO_0062012	regulation of small molecule metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the rate, frequency or extent of a small molecule metabolic process.
http://purl.obolibrary.org/obo/HP_0031816	Abnormal oral morphology	http://purl.obolibrary.org/obo/HP_0000153	Abnormality of the mouth		Any structural anomaly of the mouth, which is also known as the oral cavity.
http://purl.obolibrary.org/obo/HP_0031826	Abnormal reflex	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		Any anomaly of a reflex, i.e., of an automatic response mediated by the nervous system (a reflex does not need the intervention of conscious thought to occur).
http://purl.obolibrary.org/obo/HP_0031828	Abnormal superficial reflex	http://purl.obolibrary.org/obo/HP_0031826	Abnormal reflex		An anomaly of a reflex that is elicited as a motor response to scraping of the skin. They are generally graded as present or absent. They differ from tendon reflexes in that the sensory signal must ascend the spinal cord to reach the brain and then descend the spinal cord to reach the motor neurons.
http://purl.obolibrary.org/obo/HP_0031842	Lymphangiectasis	http://purl.obolibrary.org/obo/HP_0100766	Abnormal lymphatic vessel morphology		Dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma.
http://purl.obolibrary.org/obo/HP_0031850	Abnormal hematocrit	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Any deviation from the normal ratio of the volume of red blood cells to the total volume of blood.
http://purl.obolibrary.org/obo/HP_0031857	Ineffective esophageal peristalsis	http://purl.obolibrary.org/obo/HP_0025270	Abnormal esophagus physiology		Reduced or inadequate esophageal peristalsis, with resultant slow passage of contents through the esophagus.
http://purl.obolibrary.org/obo/HP_0031865	Abnormal liver physiology	http://purl.obolibrary.org/obo/HP_0025155	Abnormal hepatobiliary system physiology		Any functional anomaly of the liver.
http://purl.obolibrary.org/obo/HP_0031886	Abnormal LDL cholesterol concentration	http://purl.obolibrary.org/obo/HP_0010979	Abnormal circulating lipoprotein cholesterol concentration		Any deviation from the normal concentration of low-density lipoprotein cholesterol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031888	Abnormal circulating HDL-C concentration	http://purl.obolibrary.org/obo/HP_0010979	Abnormal circulating lipoprotein cholesterol concentration		Any deviation from the normal concentration of high-density lipoprotein (HDL) cholesterol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031889	Abnormal circulating VLDL-C concentration	http://purl.obolibrary.org/obo/HP_0010979	Abnormal circulating lipoprotein cholesterol concentration		Any deviation from the normal concentration of very-low-density lipoprotein cholesterol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031899	Abnormal coagulation factor V activity	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Any deviation from the activity of coagulation factor V.
http://purl.obolibrary.org/obo/GO_0120188	regulation of bile acid secretion	http://purl.obolibrary.org/obo/GO_0032890	regulation of organic acid transport		Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0120189	positive regulation of bile acid secretion	http://purl.obolibrary.org/obo/GO_0032892	positive regulation of organic acid transport		Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0120190	negative regulation of bile acid secretion	http://purl.obolibrary.org/obo/GO_0032891	negative regulation of organic acid transport		Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0140236	translation at presynapse	http://purl.obolibrary.org/obo/GO_0140241	translation at synapse		Translation that occurs at the presynapse.
http://purl.obolibrary.org/obo/GO_0140237	translation at presynapse, modulating chemical synaptic transmission	http://purl.obolibrary.org/obo/GO_0140236	translation at presynapse		Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
http://purl.obolibrary.org/obo/GO_0140239	postsynaptic endocytosis	http://purl.obolibrary.org/obo/GO_0099003	vesicle-mediated transport in synapse		A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
http://purl.obolibrary.org/obo/GO_0140241	translation at synapse	http://purl.obolibrary.org/obo/GO_0006412	translation		Translation that occurs at the synapse.
http://purl.obolibrary.org/obo/GO_0140242	translation at postsynapse	http://purl.obolibrary.org/obo/GO_0140241	translation at synapse		Translation that occurs at the postsynapse.
http://purl.obolibrary.org/obo/GO_0140243	regulation of translation at synapse	http://purl.obolibrary.org/obo/GO_0006417	regulation of translation		Any process that regulates translation occurring at the synapse.
http://purl.obolibrary.org/obo/GO_0140245	regulation of translation at postsynapse	http://purl.obolibrary.org/obo/GO_0140243	regulation of translation at synapse		Any process that regulates translation occurring at the postsynapse.
http://purl.obolibrary.org/obo/CHEBI_142163	24G7 epitope	http://purl.obolibrary.org/obo/CHEBI_24433	group		An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXα, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.
http://purl.obolibrary.org/obo/CHEBI_142355	purines D-ribonucleoside	http://purl.obolibrary.org/obo/CHEBI_26399	purine ribonucleoside		A purine ribonucleoside that is a purine derivative attached to a β-<small>D</small>-ribofuranosyl residue at position 9 via a glycosidic (<em>N</em>-glycosyl) linkage.
http://purl.obolibrary.org/obo/UBERON_0036304	anatomical border	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure that is located along the line dividing two regions of an anatomical structure.
http://purl.obolibrary.org/obo/HP_0033345	Neuralgia	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain (An unpleasant sensory and emotional experience) along the course of a nerve.
http://purl.obolibrary.org/obo/HP_0033346	Psychic epileptic aura	http://purl.obolibrary.org/obo/HP_0033348	Epileptic aura		Aura with affective, mnemonic or composite perceptual phenomena including illusory or composite hallucinatory events.
http://purl.obolibrary.org/obo/HP_0033347	Cognitive epileptic aura	http://purl.obolibrary.org/obo/HP_0033346	Psychic epileptic aura		A purely subjective manifestation of an epileptic seizure pertaining to altered cognition.
http://purl.obolibrary.org/obo/HP_0033348	Epileptic aura	http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure		An epileptic aura is a purely subjective clinical manifestation of an epileptic seizure. If an epileptic aura is not followed by loss of awareness or propagation to a bilateral tonic-clonic seizure then it is a type of focal aware non-motor seizure.
http://purl.obolibrary.org/obo/UBERON_0039377	urethral vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that drains the urethra.
http://purl.obolibrary.org/obo/UBERON_7500073	left nasal bone	http://purl.obolibrary.org/obo/UBERON_0001681	nasal bone		Nasal bone on the left side of an organism when in anatomical position.
http://purl.obolibrary.org/obo/UBERON_7500074	right nasal bone	http://purl.obolibrary.org/obo/UBERON_0001681	nasal bone		Nasal bone on the right side of an organism when in anatomical position.
http://purl.obolibrary.org/obo/UBERON_7500075	left zygomatic arch	http://purl.obolibrary.org/obo/UBERON_0002500	zygomatic arch		Zygomatic arch on the left side of an organism when in anatomical position.
http://purl.obolibrary.org/obo/UBERON_7500076	right zygomatic arch	http://purl.obolibrary.org/obo/UBERON_0002500	zygomatic arch		Zygomatic arch on the right side of an organism when in anatomical position.
http://purl.obolibrary.org/obo/UBERON_8410068	capillary of small intestine	http://purl.obolibrary.org/obo/UBERON_0001982	capillary		A capillary that is part of a small intestine.
http://purl.obolibrary.org/obo/CL_4023068	thalamic excitatory neuron	http://purl.obolibrary.org/obo/CL_0012001	neuron of the forebrain		An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response.
http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by administration of a medication.
http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		History of events that precede the current presenting condition and are thought to be of potential relevance, having occurred in the hours, days, or weeks before the current condition.
http://purl.obolibrary.org/obo/CHEBI_194240	omega-methyl-medium-chain fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_76619	omega-methyl fatty acid anion		A medium-chain fatty acid anion obtained by deprotonation of the carboxy group of any ω-methyl fatty acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/HP_4000183	Abnormal erythrocyte adenosine triphosphate concentration	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) outside of the normal range.
http://purl.obolibrary.org/obo/HP_4000184	Reduced erythrocyte adenosine triphosphate concentration	http://purl.obolibrary.org/obo/HP_4000183	Abnormal erythrocyte adenosine triphosphate concentration		Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_4000186	Elevated erythrocyte adenosine triphosphate concentration	http://purl.obolibrary.org/obo/HP_4000183	Abnormal erythrocyte adenosine triphosphate concentration		Concentration of adenosine triphosphate (ATP) in red blood cells (erythrocytes) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_5201009	Complete cleft of the upper lip	http://purl.obolibrary.org/obo/HP_0000204	Cleft upper lip		Cleft of the upper lip that starts from the bottom of the upper lip and reaches the nasal cavity.
http://purl.obolibrary.org/obo/HP_5201010	Microform cleft of the upper lip	http://purl.obolibrary.org/obo/HP_0000204	Cleft upper lip		Notch, groove, or scar of the upper lip without noticeable rupture of the lip.
http://purl.obolibrary.org/obo/HP_5201011	Complete bilateral cleft lip	http://purl.obolibrary.org/obo/HP_0100336	Bilateral cleft lip		Bilateral cleft lip in which the cleft lip on both sides is complete, i.e. start from the bottom of the upper lip and reach the nasal cavity.
http://purl.obolibrary.org/obo/HP_5201012	Incomplete bilateral cleft lip	http://purl.obolibrary.org/obo/HP_0100336	Bilateral cleft lip		Bilateral cleft lip in which the cleft lip on both sides are incomplete (i.e. start from the bottom of the upper lip but do not reach the nasal cavity), or the cleft lip on one is incomplete and a microform on the other side.
http://purl.obolibrary.org/obo/HP_5201013	Microform bilateral cleft lip	http://purl.obolibrary.org/obo/HP_0100336	Bilateral cleft lip		Bilateral cleft lip in which the cleft lip on both sides are microform, i.e. a notch, groove, or scar without noticeable rupture of the lip.
http://purl.obolibrary.org/obo/HP_5201014	Asymmetric bilateral cleft lip	http://purl.obolibrary.org/obo/HP_0100336	Bilateral cleft lip		Bilateral cleft lip in which the cleft lip on one side is complete (i.e. starts from the bottom of the upper lip and reaches the nasal cavity), and the one on the other side is incomplete (i.e. starts from the bottom of the upper lip but does not reach the nasal cavity) or microform (i.e. a notch, groove, or scar without noticeable rupture of the lip).
http://purl.obolibrary.org/obo/GO_0141061	disruption of cell in another organism	http://purl.obolibrary.org/obo/GO_0141060	disruption of anatomical structure in another organism		The disruption of a cell of another organism, leading to damage or temporary subversion of that cell.
http://purl.obolibrary.org/obo/CL_4040003	fetal pre-type II pulmonary alveolar epithelial cell	http://purl.obolibrary.org/obo/CL_0000322	pulmonary alveolar epithelial cell		Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity.
http://purl.obolibrary.org/obo/UBERON_8480068	saphenous vein smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004696	venous system smooth muscle		A portion of smooth muscle tissue that is part of a saphenous vein.
http://purl.obolibrary.org/obo/UBERON_8480074	skin of gonad	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A zone of skin part of some gonad.
http://purl.obolibrary.org/obo/CL_0008053	circumventricular organ capillary endothelial cell	http://purl.obolibrary.org/obo/CL_2000044	brain microvascular endothelial cell		A capillary endothelial cell that is part of the circumventricular organs (CVOs), characterized by fenestrations that facilitate selective permeability to molecules, distinguishing it from the non-fenestrated endothelial cells of the blood-brain barrier. This cell is integral to the unique vascular structure of CVOs, which lack a traditional blood-brain barrier. It enables bidirectional exchange of polar molecules between blood and neural tissue, supporting neuroendocrine signaling, fluid balance, and immune responses. It is marked by the expression of PLVAP, a component of the fenestral diaphragm, in both rodents and humans.
http://purl.obolibrary.org/obo/CL_0008055	respiratory tract secretory epithelial cell	http://purl.obolibrary.org/obo/CL_0002368	respiratory tract epithelial cell		A secretory epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin.
http://purl.obolibrary.org/obo/CL_4052045	steroidogenic stromal cell of ovary	http://purl.obolibrary.org/obo/CL_0002132	stromal cell of ovary		A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones.
http://purl.obolibrary.org/obo/CL_4052060	spinous cell	http://purl.obolibrary.org/obo/CL_0000312	keratinocyte		A differentiating keratinocyte found in the epidermis and oral epithelium, located in the stratum spinosum, characterized by a spiny appearance due to abundant intercellular desmosomal junctions.
http://purl.obolibrary.org/obo/HP_5210135	Unusual genitourinary infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection of the genitourinary tract, as manifested by recurrent or severe cystitis, pyelonephritis, kidney abscess, or vaginal infection, or by genitourinary infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210280	Unusual oral cavity infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Infection of the oral cavity including the gingiva, periodontium, teeth, tongue, or oral mucosa that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210121	Unusual upper respiratory tract infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection of the upper respiratory tract, as manifested by recurrent or severe infection of the nose, sinuses, pharynx, larynx, or middle ear, or by infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210123	Unusual lower respiratory tract infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection of the lower respiratory tract, as manifested by recurrent or severe infection of the trachea, bronchi, bronchioles, or lung parenchyma, or by infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210099	Unusual Aspergillus infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Increased susceptibility to Aspergillus infections as manifested by recurrent or severe/invasive infection with Aspergillus, or by Aspergillus infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210003	Unusual Staphylococcus aureus infection	http://purl.obolibrary.org/obo/HP_5210001	Unusual gram-positive bacterial infection		Increased susceptibility to Staphylococcus aureus infections as manifested by recurrent or severe/invasive infection with Staphylococcus aureus, or by Staphylococcus aureus infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210236	Unusual fungal skin infection	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		An increased susceptibility to fungal infection of the skin or subcutaneous tissue, as manifested by a recurrent, severe, or atypically distributed fungal lesion, or by an infection caused by an atypical or opportunistic organism. Common manifestations include chronic mucocutaneous candidiasis or subcutaneous mycoses (such as sporotrichosis caused by Sporothrix species.
http://purl.obolibrary.org/obo/HP_5210091	Unusual Escherichia coli infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Escherichia coli infections as manifested by recurrent or severe/invasive infection with Escherichia coli, or by Escherichia coli infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210046	Unusual Serratia infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Increased susceptibility to Serratia infections as manifested by recurrent or severe/invasive infection with Serratia, or by Serratia infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210040	Unusual Klebsiella infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Klebsiella infections as manifested by recurrent or severe/invasive infection with Klebsiella, or by Klebsiella infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210079	Unusual Burkholderia cepacia infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Increased susceptibility to Burkholderia cepacia infections as manifested by recurrent or severe/invasive infection with Burkholderia cepacia, or by Burkholderia cepacia infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration	http://purl.obolibrary.org/obo/HP_0032180	Abnormal circulating metabolite concentration		The concentration of one or more vitamins is outside the reference range.
http://purl.obolibrary.org/obo/HP_5210070	Unusual Haemophilus influenzae infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Haemophilus influenzae infections as manifested by recurrent or severe/invasive infection with Haemophilus influenzae, or by Haemophilus influenzae infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210067	Unusual Neisseria meningitidis infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Neisseria meningitidis infections as manifested by recurrent or severe/invasive infection with Neisseria meningitidis, or by Neisseria meningitidis infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210102	Unusual Candida infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Increased susceptibility to Candida infections as manifested by recurrent or severe/invasive infection with Candida, or by Candida infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210139	Infectious hepatitis	http://purl.obolibrary.org/obo/HP_5210138	Unusual liver infection		Inflammation of the liver tissue caused by an infectious agent, most commonly viruses (e.g., Hepatitis A, B, C), but also potentially by bacteria, parasites, or fungi. It is characterized by diffuse involvement of the liver parenchyma.
http://purl.obolibrary.org/obo/HP_5210217	Bacterial meningitis	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		A meningitis caused by bacterial infection, with common causative organisms including Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b. A recurrent or invasive bacterial meningitis with encapsulated organisms can be a manifestation of unusual susceptibility to infection, particularly in antibody deficiencies, complement deficiencies, and asplenia.
http://purl.obolibrary.org/obo/HP_0020317	Abnormal abdominal aorta branch artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		A structural anomaly of an artery that originates from the abdominal aorta.
http://purl.obolibrary.org/obo/HP_5210252	Unusual oral thrush	http://purl.obolibrary.org/obo/HP_5210102	Unusual Candida infection		Increased susceptibility to oral candidiasis caused by Candida albicans, as manifested by recurrent or severe infection of the oral mucosa, or by oral thrush occurring beyond the neonatal period without an identifiable predisposing cause.
http://purl.obolibrary.org/obo/HP_0020347	Abnormal circulating monosaccharide concentration	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		A deviation from the normal concentration of a monosaccharide in the blood circulation.
http://purl.obolibrary.org/obo/HP_5210251	Recurrent stomatitis	http://purl.obolibrary.org/obo/HP_0020342	Unusual stomatitis		Increased susceptibility to infectious stomatitis, as manifested by recurrent episodes of oral mucosal infection that are unusual in frequency or severity for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		Increased susceptibility to mycobacterial infections as manifested by recurrent or severe/disseminated infection with mycobacterial organisms, including Mycobacterium tuberculosis, non-tuberculous mycobacteria (NTM), or BCG.
http://purl.obolibrary.org/obo/HP_0020330	Abnormal circulating inorganic anion concentration	http://purl.obolibrary.org/obo/HP_0003111	Abnormal circulating electrolyte concentration		Any deviation from the normal concentration of inorganic anion in the blood circulation.
http://purl.obolibrary.org/obo/HP_5210238	Unusual nail infection	http://purl.obolibrary.org/obo/HP_0032162	Unusual skin infection		Increased susceptibility to infection of the nail apparatus, including the nail plate, nail bed, nail matrix, and proximal nail fold, as manifested by recurrent or severe nail infection, or by nail infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210340	Non-caseating granulomatosis	http://purl.obolibrary.org/obo/HP_5210338	Non-infectious granulomatosis		Granulomatous inflammation characterized by the formation of multiple granulomas without central caseation necrosis.
http://purl.obolibrary.org/obo/HP_5210240	Unusual HSV infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to herpes simplex virus (HSV) infections as manifested by recurrent or severe/invasive infection with HSV, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_0020351	Abnormal CSF folate concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of folate or one of its metabolites in the cerebrospinal fluid (CSF) is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_5210191	Unusual cystitis	http://purl.obolibrary.org/obo/HP_5210135	Unusual genitourinary infection		Increased susceptibility to cystitis, as manifested by recurrent or severe infection of the urinary bladder, or by cystitis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210195	Unusual pyelonephritis	http://purl.obolibrary.org/obo/HP_5210135	Unusual genitourinary infection		An inflammation of the kidney involving the renal parenchyma, pelvis, and calices, occurring in a manner unusual for a healthy individual of the same age, as manifested by recurrent or severe episodes of pyelonephritis, or by pyelonephritis caused by an atypical or opportunistic organism
http://purl.obolibrary.org/obo/HP_5210286	Unusual EBV infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to Epstein-Barr virus (EBV) infections as manifested by severe or disseminated disease or impaired control of EBV infection.
http://purl.obolibrary.org/obo/HP_5210408	BCG-associated disease	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		An adverse disease following vaccination with the Bacillus Calmette-Guérin (BCG) live attenuated Mycobacterium bovis vaccine, ranging from local BCGitis (regional lymphadenitis or injection-site abscess) to disseminated BCGosis. BCG associated disease can be a manifestation of unusual susceptibility to infection, particularly in severe combined immunodeficiency, Mendelian susceptibility to mycobacterial disease (MSMD), and chronic granulomatous disease.
http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		Increased susceptibility to bacterial infections as manifested by recurrent or severe/invasive bacterial infection, or by bacterial infection in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210310	Unusual norovirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to norovirus infections as manifested by recurrent or severe/invasive infection with norovirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210127	Unusual Toxoplasma infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		Increased susceptibility to Toxoplasma gondii infections as manifested by recurrent or severe/invasive infection with Toxoplasma gondii, or by Toxoplasma gondii infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_0020318	Posterior humeral circumflex artery occlusion	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Blockage of the posterior circumflex humeral artery (PCHA), which arises from the third part of the axillary artery and supplies the shoulder joint and a number of its associated muscles. The lesion can be ascertained angiographically, whereby dye is injected both with patient's humerus at the side of the body and again with shoulder held in abduction and external rotation. Test is positive if there is evidence of PCHA occlusion with arm in abduction and external rotation but artery is patent when arm is held at the side.
http://purl.obolibrary.org/obo/HP_0020319	Scapulothoracic incongruity	http://purl.obolibrary.org/obo/HP_0000782	Abnormal scapula morphology		A lack of smooth, physiological alignment or movement between the scapula (shoulder blade) and the posterior thoracic wall (the rib cage). The scapulothoracic joint is unique, as it lacks true synovial articulation and is dynamically controlled through surrounding muscular contractions. The scapula glides on the posterior thorax covered with muscle layers rather than a cartilaginous surface. This feature can be ascertained by radiography or CT scan of the scapula showing incongruity of the scapulothoracic space.
http://purl.obolibrary.org/obo/HP_0020320	Latissimus dorsi rupture	http://purl.obolibrary.org/obo/HP_0009127	Abnormal appendicular muscle morphology		A tear of the latissimus dorsi (LD). Injury to the LD can occur at various locations, from the tendon to the muscle belly. The LD is a broad, flat muscle occupying most of the lower posterior thorax. The muscle's primary function is to move the upper extremity, but it is also considered an accessory muscle of respiration.
http://purl.obolibrary.org/obo/HP_0020321	Distal clavicular osteolysis	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		Degeneration and resorption of the distal part of the clavicle near the acromioclavicular (AC) joint. Distal clavicular osteolysis (DCO) is an atypical injury occurring most often in athletes and weight lifters, specifically those who perform repetitive overhead movements. DCO results from repetitive excess load to the AC joint, typically through horizontal adduction, adduction, internal rotation, and forward/lateral flexion of the shoulder, such as bench pressing or overhead lifting. Imaging (AP clavicle and/or Zanca view of the AC joint) of DCO often demonstrates microcysts, loss of subchondral bone detail, and osteolysis of the distal clavicle.
http://purl.obolibrary.org/obo/HP_0020322	Abnormal breast-tissue biospecimen	http://purl.obolibrary.org/obo/HP_0020228	Biospecimen phenotypic feature		Any abnormal phenotypic feature observed in a biospecimen derived from breast tissue.
http://purl.obolibrary.org/obo/HP_0020323	Abnormal breast-tissue cellular antigen expression	http://purl.obolibrary.org/obo/HP_0020322	Abnormal breast-tissue biospecimen		Abnormal expression of an antigen (marker) by cells located in breast tissue.
http://purl.obolibrary.org/obo/HP_0020324	Increased breast-tissue HER2 expression	http://purl.obolibrary.org/obo/HP_0020323	Abnormal breast-tissue cellular antigen expression		Increased level of human epidermal growth factor receptor 2 (HER2) expression in breast tissue.
http://purl.obolibrary.org/obo/HP_0020325	Increased breast-tissue estrogen receptor expression	http://purl.obolibrary.org/obo/HP_0020323	Abnormal breast-tissue cellular antigen expression		Increased level of estrogen receptor expression in breast tissue.
http://purl.obolibrary.org/obo/HP_0020327	Abnormal breast-tissue cellular finding	http://purl.obolibrary.org/obo/HP_0020322	Abnormal breast-tissue biospecimen		Any phenotypic abnormality within cells located in breast tissue.
http://purl.obolibrary.org/obo/HP_0020328	Mammary ductal epithelial cell hyperplasia	http://purl.obolibrary.org/obo/HP_0020327	Abnormal breast-tissue cellular finding		Abnormal (increased) proliferation of epithelial cells in a mammary duct. Intraductal papilloma is a benign tumor found within breast ducts. The abnormal proliferation of ductal epithelial cells causes growth. A solitary intraductal papilloma is usually found centrally posterior to the nipple, affecting the central duct.
http://purl.obolibrary.org/obo/HP_0020329	Mammary ductal apocrine metaplasia	http://purl.obolibrary.org/obo/HP_0020327	Abnormal breast-tissue cellular finding		A biopsy finding in breast tissue of enlarged epithelial cells with abundant granular eosinophilic cytoplasm that can show apical snouting. Metaplastic apocrine cells within the breast are similar to normal axillary, areolar and perineal apocrine cells, having apocrine secretions and identical staining reactions. One of the reasons, however, that these are often not regarded as normal components is that examples of gradual metaplastic change from the normal cuboidal epithelium can be seen and cells with intermediate features can also be discerned on careful examination, suggesting that these are true metaplasia.
http://purl.obolibrary.org/obo/HP_0020331	Blue-field entoptic phenomenon	http://purl.obolibrary.org/obo/HP_6001103	Entoptic phenomenon		Unremitting, positive visual phenomena, present in the entire visual field and characterized by uncountable tiny flickering dots interposed between the person's vision and the background. The dots are said to resemble static and are typically black and white but can also be colored, flashing, or transparent. In addition to the static, or snow, patients can experience additional visual symptoms of either direct neurological origin, such as palinopsia, photophobia, and nyctalopia (i.e., impaired night vision), or that arise from the optic apparatus.
http://purl.obolibrary.org/obo/HP_0020332	Phosphene	http://purl.obolibrary.org/obo/HP_6001103	Entoptic phenomenon		A phosphene is the perception of light without light actually entering the eye, for instance caused by pressure applied to the closed eyes.
http://purl.obolibrary.org/obo/HP_0020333	Palinopsia	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Palinopsia refers to visual images that persist despite removal of the eliciting object; plainopsia presents as persistent afterimages of stationary objects or trailing of images behind moving objects.
http://purl.obolibrary.org/obo/HP_0020334	Positive scapular compression test	http://purl.obolibrary.org/obo/HP_0025823	Positive provocative functional shoulder test		A type of function test in which the examiner uses one hand to apply a posterior to anterior force is directly over the scapula and the anterior chest wall is stabilized with the other hand. Test is positive if this scapular stabilization allows for increased shoulder flexion compared to when no stabilization is applied.
http://purl.obolibrary.org/obo/HP_0020335	Pectoralis major tear	http://purl.obolibrary.org/obo/HP_0011957	Abnormal pectoral muscle morphology		Injury with partial or complete tear of the pectoralis major tendon, muscle, or myotendinous junction.
http://purl.obolibrary.org/obo/HP_0020336	Increased urinary 18-oxocortisol level	http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level		The amount of 18-oxocortisol in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020337	Increased urinary 18-hydroxycortisol level	http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level		The amount of 18-hydroxycortisol in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020338	Malignant melanotic nerve sheath tumor	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		Malignant melanotic nerve sheath tumors (MMNSTs) are uncommon pigmented tumors of Schwann cell origin, most often found along the spinal nerves. MMNSTs were formerly known as melanotic schwannoma. Although MMNSTs can occur along cranial nerves, they tend to grow along the dorsal spinal nerve roots, and patients often present with indolent pain, weakness, or paresthesia along a corresponding dermatome. On imaging, spinal MMNSTs generally appear similar to the appearance presented in the current case: intradural, extramedullary tumors. In the spine, the tumors typically grow along spinal nerve roots, sometimes assuming a dumbbell configuration if they extend through a foramen. Tumors demonstrate enhancement on CT and are FDG-avid on PET.
http://purl.obolibrary.org/obo/HP_0020339	Increased mucosal-associated invariant T cell proportion	http://purl.obolibrary.org/obo/HP_0020340	Abnormal mucosal-associated invariant T cell proportion		An increased proportion of mucosal-associated invariant T (MAIT) cells among peripheral blood T lymphocytes, above the upper reference limit for age. MAIT cells are innate-like T cells that recognise riboflavin metabolite antigens presented by MR1.
http://purl.obolibrary.org/obo/HP_0020340	Abnormal mucosal-associated invariant T cell proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		An increased or decreased proportion of mucosal-associated invariant T (MAIT) cells among peripheral blood T lymphocytes, above the upper reference limit for age. MAIT cells are innate-like T cells that recognise riboflavin metabolite antigens presented by MR1.
http://purl.obolibrary.org/obo/HP_0020343	Unusual pharyngitis	http://purl.obolibrary.org/obo/HP_0025439	Pharyngitis		Increased susceptibility to infection of the pharynx, as manifested by recurrent or severe episodes of pharyngitis.
http://purl.obolibrary.org/obo/HP_0020344	Abnormal mental imagery	http://purl.obolibrary.org/obo/HP_0025792	Abnormal cognitive process		A deviation from the typical ability to voluntarily generate, maintain, or experience mental images representing sensory properties of objects or events without a direct external stimulus.
http://purl.obolibrary.org/obo/HP_0020345	Aphantasia	http://purl.obolibrary.org/obo/HP_0020344	Abnormal mental imagery		Absence or near-absence of voluntary visual mental imagery, such that an individual is unable to intentionally generate visual images in the mind.
http://purl.obolibrary.org/obo/HP_0020346	Hyperphantasia	http://purl.obolibrary.org/obo/HP_0020344	Abnormal mental imagery		Exceptionally vivid voluntary visual mental imagery, in which internally generated images are experienced as vivid, despite intact reality testing and the absence of sensory hallucinations.
http://purl.obolibrary.org/obo/HP_0020348	Abnormal circulating disaccharide concentration	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		A deviation from the normal concentration of a disaccharide in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		A deviation from the normal concentration of a sugar alcohol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020352	Lisfranc injury	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		Lisfranc injuries refer to bony or ligamentous compromise of the tarsometatarsal and intercuneiform joint complex and include a spectrum of injuries ranging from a stable, partial sprain to a grossly displaced and unstable fracture or fracture-dislocation of the midfoot. Foot x-ray shows either widening of the space between the 1st and 2nd metatarsal to over 2mm at the base, dorsal displacement of the base of the 1st or 2nd metatarsal, discontinuity of a line drawn from the medial base of the 2nd metatarsal to the medial side of the medial cuneiform, irregularity between the medial side of the 5th metatarsal base and the medial side of the cuboid, or disruption of the line connecting the medial aspect of the navicular bone to the medial cuneiform.
http://purl.obolibrary.org/obo/HP_5210146	Unusual cytomegalovirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to cytomegalovirus (CMV) infections as manifested by severe, invasive, persistent, or disseminated CMV infection.
http://purl.obolibrary.org/obo/HP_5210101	Unusual adenovirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to adenovirus infections as manifested by recurrent or severe/invasive infection with adenovirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210323	Unusual parainfluenza infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to parainfluenza virus infections as manifested by recurrent or severe/invasive infection with parainfluenza virus.
http://purl.obolibrary.org/obo/HP_5210119	Unusual Cryptosporidium infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		Increased susceptibility to Cryptosporidium infections as manifested by recurrent or severe/invasive infection with Cryptosporidium, or by Cryptosporidium infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210232	Unusual viral skin infection	http://purl.obolibrary.org/obo/HP_0032162	Unusual skin infection		An increased susceptibility to viral infection of the skin, as manifested by a recurrent or severe cutaneous viral infection, or by a skin infection caused by an atypical or opportunistic organism. Common causative organisms include herpes simplex virus, varicella-zoster virus, human papillomavirus, and Molluscum contagiosum.
http://purl.obolibrary.org/obo/HP_5210116	Unusual VZV infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to varicella-zoster virus (VZV) infections as manifested by recurrent or severe/invasive infection with VZV, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210338	Non-infectious granulomatosis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		Granulomatous inflammation involving the formation of multiple granulomas not attributable to a causative infectious agent, arising in the context of immune dysregulation, foreign-body reactions or idiopathic.
http://purl.obolibrary.org/obo/HP_5210115	Non-tuberculous mycobacterial infection	http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection		Increased susceptibility to non-tuberculous mycobacteria (NTM) infections as manifested by recurrent or severe/invasive infection with NTM, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210375	Unusual dermatophyte infection	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		An increased susceptibility to dermatophytes infections as manifested by a recurrent or severe/invasive infection with dermatophytes, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210134	Unusual cholangitis	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		Increased susceptibility to infectious cholangitis, as manifested by recurrent or severe infection of the biliary tract, or by cholangitis occurring in an unusual clinical context such as absence of cholelithiasis or biliary obstruction. Causative agents include bacteria (Escherichia coli, Klebsiella pneumoniae, Enterococcus species) and fungi (Candida species).
http://purl.obolibrary.org/obo/HP_5210182	Unusual viral colitis	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A colitis caused by viral infection, with causative organisms including cytomegalovirus, adenovirus, norovirus, and enterovirus.
http://purl.obolibrary.org/obo/HP_5210216	Viral meningitis	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A meningitis caused by viral infection, with common causative organisms including herpes simplex virus, varicella-zoster virus, enterovirus, and CMV. A recurrent or chronic viral meningitis (particularly chronic enteroviral meningoencephalitis) can be a manifestation of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210339	Caseating granulomatosis	http://purl.obolibrary.org/obo/HP_5210337	Infectious granulomatosis		Granulomatous inflammation characterized by the formation of multiple granulomas exhibiting caseation necrosis, in which the necrotic tissue acquires an amorphous, cheese-like appearance.
http://purl.obolibrary.org/obo/HP_5210320	Unusual influenza infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to influenza virus infections as manifested by recurrent or severe/invasive infection with influenza virus.
http://purl.obolibrary.org/obo/HP_5200023	Abnormal HLA-DR+ T cell proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		The proportion of peripheral blood T lymphocytes expressing HLA-DR (CD3+HLA-DR+) is outside of the reference limit for age.
http://purl.obolibrary.org/obo/HP_5200033	Increased HLA-DR+ T cell proportion	http://purl.obolibrary.org/obo/HP_5200023	Abnormal HLA-DR+ T cell proportion		The proportion of peripheral blood T lymphocytes expressing HLA-DR (CD3+HLA-DR+) is above the upper reference limit for age.
http://purl.obolibrary.org/obo/HP_5200034	Decreased HLA-DR+ T cell proportion	http://purl.obolibrary.org/obo/HP_5200023	Abnormal HLA-DR+ T cell proportion		The proportion of peripheral blood T lymphocytes expressing HLA-DR (CD3+HLA-DR+) is below the upper reference limit for age.
http://purl.obolibrary.org/obo/HP_5210001	Unusual gram-positive bacterial infection	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		Increased susceptibility to gram-positive bacterial infections as manifested by recurrent or severe/invasive infection with gram-positive organisms.
http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		Increased susceptibility to gram-negative bacterial infections as manifested by recurrent or severe/invasive infection with gram-negative organisms.
http://purl.obolibrary.org/obo/HP_5210004	Severe Staphylococcus aureus infection	http://purl.obolibrary.org/obo/HP_5210003	Unusual Staphylococcus aureus infection		Increased susceptibility to Staphylococcus aureus infections as manifested by a severe or invasive infection with Staphylococcus aureus.
http://purl.obolibrary.org/obo/HP_5210005	Chronic absent circulating IgA	http://purl.obolibrary.org/obo/HP_0002720	Decreased circulating IgA concentration		An absence of total immunoglobulin A (IgA) in the circulation that persists for more than 6 months.
http://purl.obolibrary.org/obo/HP_5210006	Unusual Enterococcus infection	http://purl.obolibrary.org/obo/HP_5210001	Unusual gram-positive bacterial infection		Increased susceptibility to Enterococcus infections as manifested by recurrent or severe/invasive infection with Enterococcus, or by Enterococcus infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210007	Severe Enterococcus infection	http://purl.obolibrary.org/obo/HP_5210006	Unusual Enterococcus infection		Increased susceptibility to Enterococcus infections as manifested by a severe or invasive infection with Enterococcus.
http://purl.obolibrary.org/obo/HP_5210008	Recurrent Enterococcus infection	http://purl.obolibrary.org/obo/HP_5210006	Unusual Enterococcus infection		Increased susceptibility to Enterococcus infections as manifested by recurrent episodes of Enterococcus infection.
http://purl.obolibrary.org/obo/HP_5210009	Unusual Streptococcus infection	http://purl.obolibrary.org/obo/HP_5210001	Unusual gram-positive bacterial infection		Increased susceptibility to Streptococcus infections as manifested by recurrent or severe/invasive infection with Streptococcus, or by Streptococcus infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210010	Unusual Streptococcus pneumoniae infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Increased susceptibility to Streptococcus pneumoniae infections as manifested by recurrent or severe/invasive infection with Streptococcus pneumoniae, or by Streptococcus pneumoniae infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210011	Severe Streptococcus pneumoniae infection	http://purl.obolibrary.org/obo/HP_5210010	Unusual Streptococcus pneumoniae infection		Increased susceptibility to Streptococcus pneumoniae infections as manifested by a severe or invasive infection with Streptococcus pneumoniae.
http://purl.obolibrary.org/obo/HP_5210012	Recurrent Streptococcus pneumoniae infection	http://purl.obolibrary.org/obo/HP_5210010	Unusual Streptococcus pneumoniae infection		Increased susceptibility to Streptococcus pneumoniae infections as manifested by recurrent episodes of Streptococcus pneumoniae infection.
http://purl.obolibrary.org/obo/HP_5210013	Unusual Streptococcus pyogenes infection	http://purl.obolibrary.org/obo/HP_5210009	Unusual Streptococcus infection		Increased susceptibility to Streptococcus pyogenes infections as manifested by recurrent or severe/invasive infection with Streptococcus pyogenes, or by Streptococcus pyogenes infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210014	Severe Streptococcus pyogenes infection	http://purl.obolibrary.org/obo/HP_5210013	Unusual Streptococcus pyogenes infection		Increased susceptibility to Streptococcus pyogenes infections as manifested by a severe or invasive infection with Streptococcus pyogenes.
http://purl.obolibrary.org/obo/HP_5210015	Recurrent Streptococcus pyogenes infection	http://purl.obolibrary.org/obo/HP_5210013	Unusual Streptococcus pyogenes infection		Increased susceptibility to Streptococcus pyogenes infections as manifested by recurrent episodes of Streptococcus pyogenes infection.
http://purl.obolibrary.org/obo/HP_5210016	Unusual Streptococcus agalactiae infection	http://purl.obolibrary.org/obo/HP_5210009	Unusual Streptococcus infection		Increased susceptibility to Streptococcus agalactiae infections as manifested by recurrent or severe/invasive infection with Streptococcus agalactiae, or by Streptococcus agalactiae infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210017	Severe Streptococcus agalactiae infection	http://purl.obolibrary.org/obo/HP_5210016	Unusual Streptococcus agalactiae infection		Increased susceptibility to Streptococcus agalactiae infections as manifested by a severe or invasive infection with Streptococcus agalactiae.
http://purl.obolibrary.org/obo/HP_5210018	Recurrent Streptococcus agalactiae infection	http://purl.obolibrary.org/obo/HP_5210016	Unusual Streptococcus agalactiae infection		Increased susceptibility to Streptococcus agalactiae infections as manifested by recurrent episodes of Streptococcus agalactiae infection.
http://purl.obolibrary.org/obo/HP_5210019	Unusual Listeria infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Increased susceptibility to Listeria infections as manifested by recurrent or severe/invasive infection with Listeria, or by Listeria infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210020	Severe Listeria infection	http://purl.obolibrary.org/obo/HP_5210019	Unusual Listeria infection		Increased susceptibility to Listeria infections as manifested by a severe or invasive infection with Listeria.
http://purl.obolibrary.org/obo/HP_5210021	Recurrent Listeria infection	http://purl.obolibrary.org/obo/HP_5210019	Unusual Listeria infection		Increased susceptibility to Listeria infections as manifested by recurrent episodes of Listeria infection.
http://purl.obolibrary.org/obo/HP_5210022	Unusual Nocardia infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Increased susceptibility to Nocardia infections as manifested by recurrent or severe/invasive infection with Nocardia, or by Nocardia infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210023	Severe Nocardia infection	http://purl.obolibrary.org/obo/HP_5210022	Unusual Nocardia infection		Increased susceptibility to Nocardia infections as manifested by a severe or invasive infection with Nocardia.
http://purl.obolibrary.org/obo/HP_5210024	Recurrent Nocardia infection	http://purl.obolibrary.org/obo/HP_5210022	Unusual Nocardia infection		Increased susceptibility to Nocardia infections as manifested by recurrent episodes of Nocardia infection.
http://purl.obolibrary.org/obo/HP_5210025	Unusual Actinomyces infection	http://purl.obolibrary.org/obo/HP_5210001	Unusual gram-positive bacterial infection		Increased susceptibility to Actinomyces infections as manifested by recurrent or severe/invasive infection with Actinomyces, or by Actinomyces infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210026	Severe Actinomyces infection	http://purl.obolibrary.org/obo/HP_5210025	Unusual Actinomyces infection		Increased susceptibility to Actinomyces infections as manifested by a severe or invasive infection with Actinomyces.
http://purl.obolibrary.org/obo/HP_5210027	Recurrent Actinomyces infection	http://purl.obolibrary.org/obo/HP_5210025	Unusual Actinomyces infection		Increased susceptibility to Actinomyces infections as manifested by recurrent episodes of Actinomyces infection.
http://purl.obolibrary.org/obo/HP_5210028	Unusual Clostridium infection	http://purl.obolibrary.org/obo/HP_5210001	Unusual gram-positive bacterial infection		Increased susceptibility to Clostridium infections as manifested by recurrent or severe/invasive infection with Clostridium, or by Clostridium infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210029	Severe Clostridium infection	http://purl.obolibrary.org/obo/HP_5210028	Unusual Clostridium infection		Increased susceptibility to Clostridium infections as manifested by a severe or invasive infection with Clostridium.
http://purl.obolibrary.org/obo/HP_5210030	Recurrent Clostridium infection	http://purl.obolibrary.org/obo/HP_5210028	Unusual Clostridium infection		Increased susceptibility to Clostridium infections as manifested by recurrent episodes of Clostridium infection.
http://purl.obolibrary.org/obo/HP_5210031	Chronic decreased circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0002850	Decreased circulating IgM concentration		A reduction in the total concentration of immunoglobulin M (IgM) in the circulation that persists for more than 6 months.
http://purl.obolibrary.org/obo/HP_5210032	Chronic absent circulating IgM	http://purl.obolibrary.org/obo/HP_0002850	Decreased circulating IgM concentration		An absence of total immunoglobulin M (IgM) in the circulation that persists for more than 6 months.
http://purl.obolibrary.org/obo/HP_5210033	Transient decreased circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0002850	Decreased circulating IgM concentration		A temporary reduction in the total concentration of immunoglobulin M (IgM) in the circulation that is documented at one or more time points but subsequently normalizes on follow-up measurement.
http://purl.obolibrary.org/obo/HP_5210034	Complete or near-complete absence of specific antibody response to unconjugated Salmonella typhi vaccine	http://purl.obolibrary.org/obo/HP_0410299	Decreased specific antibody response to unconjugated polysaccharide vaccine		Complete or near-complete absence of specific antibody production measured 4 to 6 weeks following vaccination with the unconjugated Salmonella typhi vaccine.
http://purl.obolibrary.org/obo/HP_5210035	Partial absence of specific antibody response to unconjugated Salmonella typhi vaccine	http://purl.obolibrary.org/obo/HP_0410299	Decreased specific antibody response to unconjugated polysaccharide vaccine		Partial absence of specific antibody production following vaccination with unconjugated Salmonella typhi vaccine.
http://purl.obolibrary.org/obo/HP_5210036	Decreased circulating specific Haemophilus influenzae type b antibody concentration	http://purl.obolibrary.org/obo/HP_0002848	Decreased specific anti-polysaccharide antibody concentration		The concentration in the blood circulation of specific immunoglobulins directed against the capsular polysaccharide of Haemophilus influenzae type b is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_5210037	Unusual Shigella infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Shigella infections as manifested by recurrent or severe/invasive infection with Shigella, or by Shigella infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210038	Severe Shigella infection	http://purl.obolibrary.org/obo/HP_5210037	Unusual Shigella infection		Increased susceptibility to Shigella infections as manifested by a severe or invasive infection with Shigella.
http://purl.obolibrary.org/obo/HP_5210039	Recurrent Shigella infection	http://purl.obolibrary.org/obo/HP_5210037	Unusual Shigella infection		Increased susceptibility to Shigella infections as manifested by recurrent episodes of Shigella infection.
http://purl.obolibrary.org/obo/HP_5210041	Severe Klebsiella infection	http://purl.obolibrary.org/obo/HP_5210040	Unusual Klebsiella infection		Increased susceptibility to Klebsiella infections as manifested by a severe or invasive infection with Klebsiella.
http://purl.obolibrary.org/obo/HP_5210043	Unusual Enterobacter infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Enterobacter infections as manifested by recurrent or severe/invasive infection with Enterobacter, or by Enterobacter infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210044	Severe Enterobacter infection	http://purl.obolibrary.org/obo/HP_5210043	Unusual Enterobacter infection		Increased susceptibility to Enterobacter infections as manifested by a severe or invasive infection with Enterobacter.
http://purl.obolibrary.org/obo/HP_5210045	Recurrent Enterobacter infection	http://purl.obolibrary.org/obo/HP_5210043	Unusual Enterobacter infection		Increased susceptibility to Enterobacter infections as manifested by recurrent episodes of Enterobacter infection.
http://purl.obolibrary.org/obo/HP_5210047	Severe Serratia infection	http://purl.obolibrary.org/obo/HP_5210046	Unusual Serratia infection		Increased susceptibility to Serratia infections as manifested by a severe or invasive infection with Serratia.
http://purl.obolibrary.org/obo/HP_5210049	Unusual Proteus infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Proteus infections as manifested by recurrent or severe/invasive infection with Proteus, or by Proteus infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210050	Severe Proteus infection	http://purl.obolibrary.org/obo/HP_5210049	Unusual Proteus infection		Increased susceptibility to Proteus infections as manifested by a severe or invasive infection with Proteus.
http://purl.obolibrary.org/obo/HP_5210051	Recurrent Proteus infection	http://purl.obolibrary.org/obo/HP_5210049	Unusual Proteus infection		Increased susceptibility to Proteus infections as manifested by recurrent episodes of Proteus infection.
http://purl.obolibrary.org/obo/HP_5210052	Unusual Citrobacter infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Citrobacter infections as manifested by recurrent or severe/invasive infection with Citrobacter, or by Citrobacter infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210053	Severe Citrobacter infection	http://purl.obolibrary.org/obo/HP_5210052	Unusual Citrobacter infection		Increased susceptibility to Citrobacter infections as manifested by a severe or invasive infection with Citrobacter.
http://purl.obolibrary.org/obo/HP_5210054	Recurrent Citrobacter infection	http://purl.obolibrary.org/obo/HP_5210052	Unusual Citrobacter infection		Increased susceptibility to Citrobacter infections as manifested by recurrent episodes of Citrobacter infection.
http://purl.obolibrary.org/obo/HP_5210055	Unusual Pseudomonas aeruginosa infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Increased susceptibility to Pseudomonas aeruginosa infections as manifested by recurrent or severe/invasive infection with Pseudomonas aeruginosa, or by Pseudomonas aeruginosa infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210056	Severe Pseudomonas aeruginosa infection	http://purl.obolibrary.org/obo/HP_5210055	Unusual Pseudomonas aeruginosa infection		Increased susceptibility to Pseudomonas aeruginosa infections as manifested by a severe or invasive infection with Pseudomonas aeruginosa.
http://purl.obolibrary.org/obo/HP_5210057	Recurrent Pseudomonas aeruginosa infection	http://purl.obolibrary.org/obo/HP_5210055	Unusual Pseudomonas aeruginosa infection		Increased susceptibility to Pseudomonas aeruginosa infections as manifested by recurrent episodes of Pseudomonas aeruginosa infection.
http://purl.obolibrary.org/obo/HP_5210058	Unusual Acinetobacter baumannii infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Acinetobacter baumannii infections as manifested by recurrent or severe/invasive infection with Acinetobacter baumannii, or by Acinetobacter baumannii infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210059	Severe Acinetobacter baumannii infection	http://purl.obolibrary.org/obo/HP_5210058	Unusual Acinetobacter baumannii infection		Increased susceptibility to Acinetobacter baumannii infections as manifested by a severe or invasive infection with Acinetobacter baumannii.
http://purl.obolibrary.org/obo/HP_5210060	Recurrent Acinetobacter baumannii infection	http://purl.obolibrary.org/obo/HP_5210058	Unusual Acinetobacter baumannii infection		Increased susceptibility to Acinetobacter baumannii infections as manifested by recurrent episodes of Acinetobacter baumannii infection.
http://purl.obolibrary.org/obo/HP_5210061	Unusual Legionella pneumophila infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Legionella pneumophila infections as manifested by recurrent or severe/invasive infection with Legionella pneumophila, or by Legionella pneumophila infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210062	Severe Legionella pneumophila infection	http://purl.obolibrary.org/obo/HP_5210061	Unusual Legionella pneumophila infection		Increased susceptibility to Legionella pneumophila infections as manifested by a severe or invasive infection with Legionella pneumophila.
http://purl.obolibrary.org/obo/HP_5210063	Recurrent Legionella pneumophila infection	http://purl.obolibrary.org/obo/HP_5210061	Unusual Legionella pneumophila infection		Increased susceptibility to Legionella pneumophila infections as manifested by recurrent episodes of Legionella pneumophila infection.
http://purl.obolibrary.org/obo/HP_5210064	Unusual Neisseria gonorrhoeae infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Neisseria gonorrhoeae infections as manifested by recurrent or severe/invasive infection with Neisseria gonorrhoeae, or by Neisseria gonorrhoeae infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210065	Severe Neisseria gonorrhoeae infection	http://purl.obolibrary.org/obo/HP_5210064	Unusual Neisseria gonorrhoeae infection		Increased susceptibility to Neisseria gonorrhoeae infections as manifested by a severe or invasive infection with Neisseria gonorrhoeae.
http://purl.obolibrary.org/obo/HP_5210066	Recurrent Neisseria gonorrhoeae infection	http://purl.obolibrary.org/obo/HP_5210064	Unusual Neisseria gonorrhoeae infection		Increased susceptibility to Neisseria gonorrhoeae infections as manifested by recurrent episodes of Neisseria gonorrhoeae infection.
http://purl.obolibrary.org/obo/HP_5210068	Severe Neisseria meningitidis infection	http://purl.obolibrary.org/obo/HP_5210067	Unusual Neisseria meningitidis infection		Increased susceptibility to Neisseria meningitidis infections as manifested by a severe or invasive infection with Neisseria meningitidis.
http://purl.obolibrary.org/obo/HP_5210071	Severe Haemophilus influenzae infection	http://purl.obolibrary.org/obo/HP_5210070	Unusual Haemophilus influenzae infection		Increased susceptibility to Haemophilus influenzae infections as manifested by a severe or invasive infection with Haemophilus influenzae.
http://purl.obolibrary.org/obo/HP_5210073	Unusual Moraxella catarrhalis infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Moraxella catarrhalis infections as manifested by recurrent or severe/invasive infection with Moraxella catarrhalis, or by Moraxella catarrhalis infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210074	Severe Moraxella catarrhalis infection	http://purl.obolibrary.org/obo/HP_5210073	Unusual Moraxella catarrhalis infection		Increased susceptibility to Moraxella catarrhalis infections as manifested by a severe or invasive infection with Moraxella catarrhalis.
http://purl.obolibrary.org/obo/HP_5210075	Recurrent Moraxella catarrhalis infection	http://purl.obolibrary.org/obo/HP_5210073	Unusual Moraxella catarrhalis infection		Increased susceptibility to Moraxella catarrhalis infections as manifested by recurrent episodes of Moraxella catarrhalis infection.
http://purl.obolibrary.org/obo/HP_5210076	Unusual Vibrio cholerae infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Vibrio cholerae infections as manifested by recurrent or severe/invasive infection with Vibrio cholerae, or by Vibrio cholerae infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210077	Severe Vibrio cholerae infection	http://purl.obolibrary.org/obo/HP_5210076	Unusual Vibrio cholerae infection		Increased susceptibility to Vibrio cholerae infections as manifested by a severe or invasive infection with Vibrio cholerae.
http://purl.obolibrary.org/obo/HP_5210078	Recurrent Vibrio cholerae infection	http://purl.obolibrary.org/obo/HP_5210076	Unusual Vibrio cholerae infection		Increased susceptibility to Vibrio cholerae infections as manifested by recurrent episodes of Vibrio cholerae infection.
http://purl.obolibrary.org/obo/HP_5210080	Severe Burkholderia cepacia infection	http://purl.obolibrary.org/obo/HP_5210079	Unusual Burkholderia cepacia infection		Increased susceptibility to Burkholderia cepacia infections as manifested by a severe or invasive infection with Burkholderia cepacia.
http://purl.obolibrary.org/obo/HP_5210082	Unusual Bacteroides infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Bacteroides infections as manifested by recurrent or severe/invasive infection with Bacteroides, or by Bacteroides infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210083	Severe Bacteroides infection	http://purl.obolibrary.org/obo/HP_5210082	Unusual Bacteroides infection		Increased susceptibility to Bacteroides infections as manifested by a severe or invasive infection with Bacteroides.
http://purl.obolibrary.org/obo/HP_5210084	Recurrent Bacteroides infection	http://purl.obolibrary.org/obo/HP_5210082	Unusual Bacteroides infection		Increased susceptibility to Bacteroides infections as manifested by recurrent episodes of Bacteroides infection.
http://purl.obolibrary.org/obo/HP_5210085	Unusual Fusobacterium infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Fusobacterium infections as manifested by recurrent or severe/invasive infection with Fusobacterium, or by Fusobacterium infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210086	Severe Fusobacterium infection	http://purl.obolibrary.org/obo/HP_5210085	Unusual Fusobacterium infection		Increased susceptibility to Fusobacterium infections as manifested by a severe or invasive infection with Fusobacterium.
http://purl.obolibrary.org/obo/HP_5210087	Recurrent Fusobacterium infection	http://purl.obolibrary.org/obo/HP_5210085	Unusual Fusobacterium infection		Increased susceptibility to Fusobacterium infections as manifested by recurrent episodes of Fusobacterium infection.
http://purl.obolibrary.org/obo/HP_5210088	Unusual Prevotella infection	http://purl.obolibrary.org/obo/HP_5210002	Unusual gram-negative bacterial infection		Increased susceptibility to Prevotella infections as manifested by recurrent or severe/invasive infection with Prevotella, or by Prevotella infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210089	Severe Prevotella infection	http://purl.obolibrary.org/obo/HP_5210088	Unusual Prevotella infection		Increased susceptibility to Prevotella infections as manifested by a severe or invasive infection with Prevotella.
http://purl.obolibrary.org/obo/HP_5210090	Recurrent Prevotella infection	http://purl.obolibrary.org/obo/HP_5210088	Unusual Prevotella infection		Increased susceptibility to Prevotella infections as manifested by recurrent episodes of Prevotella infection.
http://purl.obolibrary.org/obo/HP_5210092	Severe Escherichia coli infection	http://purl.obolibrary.org/obo/HP_5210091	Unusual Escherichia coli infection		Increased susceptibility to Escherichia coli infections as manifested by a severe or invasive infection with Escherichia coli.
http://purl.obolibrary.org/obo/HP_5210093	Unusual Salmonella infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Increased susceptibility to Salmonella infections as manifested by recurrent or severe/invasive infection with Salmonella, or by Salmonella infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210094	Severe Salmonella infection	http://purl.obolibrary.org/obo/HP_5210093	Unusual Salmonella infection		Increased susceptibility to Salmonella infections as manifested by a severe or invasive infection with Salmonella.
http://purl.obolibrary.org/obo/HP_5210095	Recurrent Salmonella infection	http://purl.obolibrary.org/obo/HP_5210093	Unusual Salmonella infection		Increased susceptibility to Salmonella infections as manifested by recurrent episodes of Salmonella infection.
http://purl.obolibrary.org/obo/HP_5210096	Unusual Pneumocystis jirovecii infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Increased susceptibility to Pneumocystis jirovecii infections as manifested by recurrent or severe/invasive infection with Pneumocystis jirovecii, or by Pneumocystis jirovecii infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210097	Severe Pneumocystis jirovecii infection	http://purl.obolibrary.org/obo/HP_0020101	Invasive fungal infection		Increased susceptibility to Pneumocystis jirovecii infections as manifested by a severe or invasive infection with Pneumocystis jirovecii.
http://purl.obolibrary.org/obo/HP_5210098	Recurrent Pneumocystis jirovecii infection	http://purl.obolibrary.org/obo/HP_5210096	Unusual Pneumocystis jirovecii infection		Increased susceptibility to Pneumocystis jirovecii infections as manifested by recurrent episodes of Pneumocystis jirovecii infection.
http://purl.obolibrary.org/obo/HP_5210100	Severe Aspergillus infection	http://purl.obolibrary.org/obo/HP_0020101	Invasive fungal infection		Increased susceptibility to Aspergillus infections as manifested by a severe or invasive infection with Aspergillus.
http://purl.obolibrary.org/obo/HP_5210103	Cytomegalovirus hepatitis	http://purl.obolibrary.org/obo/HP_5210146	Unusual cytomegalovirus infection		Hepatitis caused by cytomegalovirus (CMV) infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210104	Unusual BK virus infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		Increased susceptibility to BK polyomavirus infections as manifested by recurrent or severe/invasive infection with BK polyomavirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210105	Unusual Cryptococcus infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Increased susceptibility to Cryptococcus infections as manifested by recurrent or severe/invasive infection with Cryptococcus, or by Cryptococcus infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210106	Recurrent Cryptococcus infection	http://purl.obolibrary.org/obo/HP_5210105	Unusual Cryptococcus infection		Increased susceptibility to Cryptococcus infections as manifested by recurrent episodes of Cryptococcus infection.
http://purl.obolibrary.org/obo/HP_5210107	Disseminated Cryptococcus infection	http://purl.obolibrary.org/obo/HP_0020101	Invasive fungal infection		Disseminated infection with Cryptococcus, involving multiple organ systems that occurs in the context of immune deficiency.
http://purl.obolibrary.org/obo/HP_5210108	Sclerosing cholangitis due to Cryptococcus	http://purl.obolibrary.org/obo/HP_0030991	Sclerosing cholangitis		Sclerosing cholangitis caused by Cryptococcus infection that occurs in the context of immune deficiency.
http://purl.obolibrary.org/obo/HP_5210109	Chronic hepatitis due to Cryptococcus	http://purl.obolibrary.org/obo/HP_5210105	Unusual Cryptococcus infection		Chronic hepatitis caused by Cryptococcus infection that occurs in the context of immune deficiency.
http://purl.obolibrary.org/obo/HP_5210111	Tuberculosis infection	http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection		Increased susceptibility to Mycobacterium tuberculosis infections as manifested by recurrent or severe/invasive infection with Mycobacterium tuberculosis, or by Mycobacterium tuberculosis infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210112	Disseminated tuberculosis infection	http://purl.obolibrary.org/obo/HP_5210111	Tuberculosis infection		Disseminated infection with Mycobacterium tuberculosis, involving multiple organ systems. Organ-specific manifestations of disseminated tuberculosis include renal tuberculosis (tuberculous pyelonephritis, presenting with sterile pyuria and hematuria), hepatic tuberculosis, adrenal tuberculosis, and tuberculous osteomyelitis.
http://purl.obolibrary.org/obo/HP_5210113	Recurrent tuberculosis infection	http://purl.obolibrary.org/obo/HP_5210111	Tuberculosis infection		Increased susceptibility to Mycobacterium tuberculosis infections as manifested by recurrent episodes of Mycobacterium tuberculosis infection.
http://purl.obolibrary.org/obo/HP_5210114	Tuberculous osteomyelitis	http://purl.obolibrary.org/obo/HP_5210276	Unusual mycobacterial osteomyelitis		Osteomyelitis caused by Mycobacterium tuberculosis infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210276	Unusual mycobacterial osteomyelitis	http://purl.obolibrary.org/obo/HP_5210278	Unusual infectious osteomyelitis		An osteomyelitis caused by mycobacterial infection, with causative organisms including Mycobacterium tuberculosis, Mycobacterium bovis BCG (typically as a complication of BCG vaccination), and non-tuberculous mycobacteria.
http://purl.obolibrary.org/obo/HP_5210117	Recurrent non-tuberculous mycobacterial infection	http://purl.obolibrary.org/obo/HP_5210115	Non-tuberculous mycobacterial infection		Increased susceptibility to non-tuberculous mycobacteria (NTM) infections as manifested by recurrent episodes of non-tuberculous mycobacteria (NTM) infection.
http://purl.obolibrary.org/obo/HP_5210118	Opportunistic mycobacterial infection	http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection		Increased susceptibility to mycobacterial infections that rarely cause disease in immunocompetent individuals.
http://purl.obolibrary.org/obo/HP_5210120	Recurrent Cryptosporidium infection	http://purl.obolibrary.org/obo/HP_5210119	Unusual Cryptosporidium infection		Increased susceptibility to Cryptosporidium infections as manifested by recurrent episodes of Cryptosporidium infection.
http://purl.obolibrary.org/obo/HP_5210122	Sclerosing cholangitis due to Cryptosporidium infection	http://purl.obolibrary.org/obo/HP_0030991	Sclerosing cholangitis		Sclerosing cholangitis caused by Cryptosporidium infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210124	Unusual Giardia lamblia infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		Increased susceptibility to Giardia lamblia infections as manifested by recurrent or severe/invasive infection with Giardia lamblia, or by Giardia lamblia infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210125	Persistent Giardia lamblia infection	http://purl.obolibrary.org/obo/HP_5210124	Unusual Giardia lamblia infection		Increased susceptibility to Giardia lamblia infections as manifested by a chronic or persistent Giardia lamblia infection.
http://purl.obolibrary.org/obo/HP_5210126	Recurrent Giardia lamblia infection	http://purl.obolibrary.org/obo/HP_5210124	Unusual Giardia lamblia infection		Increased susceptibility to Giardia lamblia infections as manifested by recurrent episodes of Giardia lamblia infection.
http://purl.obolibrary.org/obo/HP_5210128	Unusual cardiovascular system infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection involving the heart or major vessels, as manifested by recurrent or severe endocarditis, myocarditis, pericarditis, or infectious vasculitis, or by cardiovascular infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210129	Toxoplasma infection of the central nervous system (CNS)	http://purl.obolibrary.org/obo/HP_5210127	Unusual Toxoplasma infection		Infection of the central nervous system with Toxoplasma gondii, typically presenting as cerebral toxoplasmosis.
http://purl.obolibrary.org/obo/HP_5210130	Unusual Leishmania infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		Increased susceptibility to Leishmania infections as manifested by recurrent or severe/invasive infection with Leishmania, or by Leishmania infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210131	Severe Leishmania infection	http://purl.obolibrary.org/obo/HP_5210130	Unusual Leishmania infection		Increased susceptibility to Leishmania infections as manifested by a severe or invasive infection with Leishmania.
http://purl.obolibrary.org/obo/HP_5210132	Recurrent Leishmania infection	http://purl.obolibrary.org/obo/HP_5210130	Unusual Leishmania infection		Increased susceptibility to Leishmania infections as manifested by recurrent episodes of Leishmania infection.
http://purl.obolibrary.org/obo/HP_5210133	Opportunistic parasitic infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		Increased susceptibility to parasitic infections that rarely cause disease in immunocompetent individuals.
http://purl.obolibrary.org/obo/HP_5210137	Unusual eye infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection of the eye or its adnexa, as manifested by recurrent or severe conjunctivitis, keratitis, retinitis, or other ocular infection, or by ocular infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210138	Unusual liver infection	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		An atypical or infrequent infectious process affecting the liver parenchyma that deviates from common viral or bacterial patterns. This may include infections caused by rare pathogens (e.g., specific fungi, parasites, or rare bacteria) or infections presenting with atypical clinical or pathological features.
http://purl.obolibrary.org/obo/HP_5210140	Bacterial sepsis	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		Sepsis caused by bacterial infection, characterized by a dysregulated host response to a bacterial pathogen with systemic inflammation, organ dysfunction, and potential progression to septic shock.
http://purl.obolibrary.org/obo/HP_5210141	Fungal sepsis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		Sepsis caused by fungal infection, characterized by a dysregulated host response to a fungal pathogen with systemic inflammation, organ dysfunction, and potential progression to septic shock.
http://purl.obolibrary.org/obo/HP_5210142	Viral sepsis	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Sepsis or sepsis-like syndrome caused by viral infection, characterized by a dysregulated host response to a viral pathogen with systemic inflammation, multi-organ involvement, and potential progression to circulatory and respiratory failure.
http://purl.obolibrary.org/obo/HP_5210143	Mycobacterial sepsis	http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection		Sepsis or sepsis-like systemic illness caused by mycobacterial infection, characterized by a dysregulated host response with systemic inflammation, multi-organ involvement, and disseminated mycobacterial disease.
http://purl.obolibrary.org/obo/HP_5210144	Pneumonia with consolidation	http://purl.obolibrary.org/obo/HP_0002090	Pneumonia		Pneumonia characterized by lobar or segmental consolidation on radiographic imaging, reflecting alveolar filling with inflammatory exudate that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210147	Unusual pleural empyema	http://purl.obolibrary.org/obo/HP_5210123	Unusual lower respiratory tract infection		Increased susceptibility to pleural empyema, as manifested by recurrent or severe infection of the pleural space, or by empyema occurring in an unusual clinical context such as an atypical causative organism or failure to resolve with standard therapy.
http://purl.obolibrary.org/obo/HP_5210148	Severe pleural empyema	http://purl.obolibrary.org/obo/HP_5210147	Unusual pleural empyema		Increased susceptibility to pleural empyema, as manifested by a severe or life-threatening infection of the pleural space requiring surgical drainage, decortication, or intensive care.
http://purl.obolibrary.org/obo/HP_5210149	Recurrent pleural empyema	http://purl.obolibrary.org/obo/HP_5210147	Unusual pleural empyema		Increased susceptibility to pleural empyema, as manifested by recurrent episodes of pleural space infection that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210150	Unusual endocarditis	http://purl.obolibrary.org/obo/HP_5210128	Unusual cardiovascular system infection		Increased susceptibility to infectious endocarditis, as manifested by recurrent or severe endocardial infection, or by endocarditis caused by an unusual organism.
http://purl.obolibrary.org/obo/HP_5210151	Severe endocarditis	http://purl.obolibrary.org/obo/HP_5210150	Unusual endocarditis		Increased susceptibility to infectious endocarditis, as manifested by severe or complicated endocarditis with valvular destruction, systemic emboli, or heart failure requiring surgical intervention.
http://purl.obolibrary.org/obo/HP_5210152	Recurrent endocarditis	http://purl.obolibrary.org/obo/HP_5210150	Unusual endocarditis		Increased susceptibility to infectious endocarditis, as manifested by recurrent episodes of endocardial infection that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210153	Unusual myocarditis	http://purl.obolibrary.org/obo/HP_0012819	Myocarditis		Increased susceptibility to infectious myocarditis, as manifested by recurrent or severe inflammation of the myocardium caused by infection, or by myocarditis caused by an unusual organism.
http://purl.obolibrary.org/obo/HP_5210154	Severe myocarditis	http://purl.obolibrary.org/obo/HP_5210153	Unusual myocarditis		Increased susceptibility to infectious myocarditis, as manifested by severe myocardial inflammation with haemodynamic compromise, arrhythmia, or fulminant heart failure.
http://purl.obolibrary.org/obo/HP_5210155	Recurrent myocarditis	http://purl.obolibrary.org/obo/HP_5210153	Unusual myocarditis		Increased susceptibility to infectious myocarditis, as manifested by recurrent episodes of myocardial inflammation caused by infection that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210156	Unusual pericarditis	http://purl.obolibrary.org/obo/HP_5210128	Unusual cardiovascular system infection		Increased susceptibility to infectious pericarditis, as manifested by recurrent or severe inflammation of the pericardium caused by infection, or by pericarditis caused by an unusual organism.
http://purl.obolibrary.org/obo/HP_5210157	Severe pericarditis	http://purl.obolibrary.org/obo/HP_5210156	Unusual pericarditis		Increased susceptibility to infectious pericarditis, as manifested by severe inflammation of the pericardium with pericardial effusion, tamponade, or constrictive pericarditis.
http://purl.obolibrary.org/obo/HP_5210158	Recurrent pericarditis	http://purl.obolibrary.org/obo/HP_5210156	Unusual pericarditis		Increased susceptibility to infectious pericarditis, as manifested by recurrent episodes of pericardial inflammation caused by infection that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210159	Unusual infectious vasculitis	http://purl.obolibrary.org/obo/HP_5210128	Unusual cardiovascular system infection		Increased susceptibility to vasculitis caused by infection, as manifested by recurrent or severe vascular inflammation of infectious aetiology, or by infectious vasculitis caused by an unusual organism.
http://purl.obolibrary.org/obo/HP_5210160	Severe infectious vasculitis	http://purl.obolibrary.org/obo/HP_5210159	Unusual infectious vasculitis		Increased susceptibility to vasculitis caused by infection, as manifested by severe vascular inflammation with ischaemia, infarction, or end-organ damage.
http://purl.obolibrary.org/obo/HP_5210161	Recurrent infectious vasculitis	http://purl.obolibrary.org/obo/HP_5210159	Unusual infectious vasculitis		Increased susceptibility to vasculitis caused by infection, as manifested by recurrent episodes of vascular inflammation of infectious etiology that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210163	Bacterial liver abscess	http://purl.obolibrary.org/obo/HP_0100523	Liver abscess		Abscess of the liver caused by bacterial infection. Principal causative agents include Escherichia coli, Klebsiella pneumoniae, Bacteroides species, and Staphylococcus aureus.
http://purl.obolibrary.org/obo/HP_5210164	Staphylococcal liver abscess	http://purl.obolibrary.org/obo/HP_5210163	Bacterial liver abscess		A liver abscess caused by Staphylococcus aureus infection that may arise from hematogenous spread, biliary infection, or contiguous spread.
http://purl.obolibrary.org/obo/HP_5210165	Klebsiella liver abscess	http://purl.obolibrary.org/obo/HP_5210163	Bacterial liver abscess		Abscess of the liver caused by Klebsiella species infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210166	Fungal liver abscess	http://purl.obolibrary.org/obo/HP_0100523	Liver abscess		A liver abscess caused by fungal infection, with common causative organisms including Candida species (often as part of hepatosplenic candidiasis) and Aspergillus species.
http://purl.obolibrary.org/obo/HP_5210167	Hepatic candidiasis	http://purl.obolibrary.org/obo/HP_5210166	Fungal liver abscess		Infection of the liver caused by Candida species that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210168	Parasitic liver abscess	http://purl.obolibrary.org/obo/HP_0100523	Liver abscess		A liver abscess or cystic hepatic lesion caused by parasitic infection, with principal causative organisms being Entamoeba histolytica (amoebic liver abscess) and Echinococcus species (hepatic hydatid disease).
http://purl.obolibrary.org/obo/HP_5210169	Amoebic liver abscess	http://purl.obolibrary.org/obo/HP_5210168	Parasitic liver abscess		Abscess of the liver caused by Entamoeba histolytica infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210170	Echinococcal liver cyst	http://purl.obolibrary.org/obo/HP_5210168	Parasitic liver abscess		Cystic or alveolar lesion of the liver caused by Echinococcus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210171	Hepatic schistosomiasis	http://purl.obolibrary.org/obo/HP_5210168	Parasitic liver abscess		Infection of the liver caused by Schistosoma species, occurring in the context of unusual susceptibility to infection, typically presenting with periportal fibrosis or hepatosplenomegaly.
http://purl.obolibrary.org/obo/HP_5210172	Bacterial splenic abscess	http://purl.obolibrary.org/obo/HP_0025059	Splenic abscess		A splenic abscess caused by bacterial infection, typically with organisms such as Staphylococcus aureus, Salmonella species, and gram-negative enteric bacteria. It may arise from hematogenous seeding, contiguous spread, or trauma.
http://purl.obolibrary.org/obo/HP_5210173	Fungal splenic abscess	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		A splenic abscess caused by fungal infection, often as part of hepatosplenic candidiasis.
http://purl.obolibrary.org/obo/HP_5210174	Parasitic splenic abscess	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		A splenic abscess or cystic splenic lesion caused by parasitic infection, with causative organisms including Echinococcus species (splenic hydatid disease) and Entamoeba histolytica.
http://purl.obolibrary.org/obo/HP_5210175	Unusual infectious gastroenteritis	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		An increased susceptibility to gastroenteritis of infectious etiology, as manifested by a recurrent or severe gastroenteritis, a prolonged diarrhoeal illness, or a gastroenteritis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210176	Unusual bacterial gastroenteritis	http://purl.obolibrary.org/obo/HP_5210175	Unusual infectious gastroenteritis		A gastroenteritis caused by bacterial infection, with common causative organisms including Salmonella species, Shigella species, Campylobacter, and pathogenic Escherichia coli.
http://purl.obolibrary.org/obo/HP_5210177	Unusual viral gastroenteritis	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A gastroenteritis caused by viral infection, with common causative organisms including rotavirus, norovirus, adenovirus, astrovirus, and enterovirus.
http://purl.obolibrary.org/obo/HP_5210178	Unusual fungal gastroenteritis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		A gastroenteritis caused by fungal infection, most often by Candida species. A fungal gastroenteritis can occur in any host with severely disrupted mucosal immunity or following prolonged broad-spectrum antibiotic exposure, and can be a manifestation of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210179	Unusual parasitic gastroenteritis	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		A gastroenteritis caused by parasitic infection, with causative organisms including Giardia lamblia, Cryptosporidium species, and Microsporidia.
http://purl.obolibrary.org/obo/HP_5210180	Unusual infectious colitis	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		An increased susceptibility to colitis of infectious etiology, as manifested by a recurrent or severe colonic infection, or by an infectious colitis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210181	Unusual bacterial colitis	http://purl.obolibrary.org/obo/HP_5210180	Unusual infectious colitis		A colitis caused by bacterial infection, with common causative organisms including Salmonella, Shigella, Campylobacter, enteroinvasive Escherichia coli, and Clostridioides difficile.
http://purl.obolibrary.org/obo/HP_5210183	Unusual fungal colitis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		A colitis caused by fungal infection, most commonly by Candida species.
http://purl.obolibrary.org/obo/HP_5210184	Unusual parasitic colitis	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		A colitis caused by parasitic infection, with causative organisms including Entamoeba histolytica, Cryptosporidium species, and Strongyloides stercoralis.
http://purl.obolibrary.org/obo/HP_5210185	Unusual infectious pancreatitis	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		An increased susceptibility to pancreatitis of infectious etiology, as manifested by a recurrent or severe infectious pancreatitis, or by a pancreatitis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210186	Unusual bacterial pancreatitis	http://purl.obolibrary.org/obo/HP_5210185	Unusual infectious pancreatitis		A pancreatitis caused by bacterial infection, which may occur as a complication of bacteraemia, ascending biliary infection, or invasive abdominal infection.
http://purl.obolibrary.org/obo/HP_5210187	Unusual viral pancreatitis	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A pancreatitis caused by viral infection, with causative organisms including mumps virus, cytomegalovirus, coxsackievirus, and other enteroviruses.
http://purl.obolibrary.org/obo/HP_5210188	Unusual fungal pancreatitis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		A pancreatitis caused by fungal infection. Such cases are rare and typically occur as a manifestation of disseminated invasive fungal disease (with Candida or Aspergillus species) in severely immunocompromised hosts.
http://purl.obolibrary.org/obo/HP_5210189	Unusual parasitic pancreatitis	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		A pancreatitis caused by parasitic infection, with causative organisms including Cryptosporidium species, Ascaris lumbricoides, and Echinococcus species.
http://purl.obolibrary.org/obo/HP_5210190	Unusual bacterial cholangitis	http://purl.obolibrary.org/obo/HP_5210134	Unusual cholangitis		Increased susceptibility to bacterial cholangitis, as manifested by recurrent or severe infection of the biliary tract, or by cholangitis occurring in an unusual clinical context such as absence of cholelithiasis or biliary obstruction. Principal causative agents include Escherichia coli, Klebsiella pneumoniae, and Enterococcus species.
http://purl.obolibrary.org/obo/HP_5210192	Unusual hemorrhagic cystitis	http://purl.obolibrary.org/obo/HP_5210101	Unusual adenovirus infection		Increased susceptibility to haemorrhagic cystitis, as manifested by recurrent or severe bladder infection with frank haematuria caused by viral or other atypical organisms. Its occurrence is inherently unusual and can indicate significant immune deficiency.
http://purl.obolibrary.org/obo/HP_5210193	Unusual fungal cystitis	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Increased susceptibility to fungal cystitis, as manifested by recurrent or severe infection of the urinary bladder caused by fungal organisms.
http://purl.obolibrary.org/obo/HP_5210194	Unusual bacterial cystitis	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		Increased susceptibility to bacterial cystitis, as manifested by recurrent or severe infection of the urinary bladder caused by bacteria, or by bacterial cystitis caused by an atypical organism.
http://purl.obolibrary.org/obo/HP_5210196	Unusual kidney abscess	http://purl.obolibrary.org/obo/HP_5210135	Unusual genitourinary infection		Abscess of the kidney occurring in the context of unusual susceptibility to infection, as manifested by renal abscess caused by an atypical or opportunistic organism, or by renal abscess occurring in the absence of the usual predisposing factors such as urinary tract obstruction or urolithiasis.
http://purl.obolibrary.org/obo/HP_5210197	Bacterial kidney abscess	http://purl.obolibrary.org/obo/HP_5210196	Unusual kidney abscess		Abscess of the kidney caused by bacterial infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210198	Fungal kidney abscess	http://purl.obolibrary.org/obo/HP_5210196	Unusual kidney abscess		Abscess of the kidney caused by fungal infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210199	Parasitic kidney abscess	http://purl.obolibrary.org/obo/HP_5210196	Unusual kidney abscess		Abscess of the kidney caused by parasitic infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210200	Unusual vaginal infection	http://purl.obolibrary.org/obo/HP_5210135	Unusual genitourinary infection		Increased susceptibility to vaginal infection, as manifested by recurrent or severe infection of the vagina or vulvovaginal area caused by bacterial, viral, fungal, or parasitic organisms, or by vaginal infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210201	Unusual bacterial vaginal infection	http://purl.obolibrary.org/obo/HP_5210200	Unusual vaginal infection		Increased susceptibility to bacterial vaginal infection, as manifested by recurrent or severe bacterial vaginosis or vaginal bacterial infection that is unusual in frequency or severity for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210202	Unusual viral vaginal infection	http://purl.obolibrary.org/obo/HP_5210200	Unusual vaginal infection		Increased susceptibility to viral vaginal infection, as manifested by recurrent or severe herpes simplex virus (HSV) infection of the vaginal or vulvovaginal area that can occur in the context of immune deficiency.
http://purl.obolibrary.org/obo/HP_5210203	Unusual fungal vaginal infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Increased susceptibility to vulvovaginal candidiasis, as manifested by recurrent or severe infection of the vagina or vulvovaginal area caused by Candida species. Predominantly caused by Candida albicans, with Candida glabrata in azole-resistant cases.
http://purl.obolibrary.org/obo/HP_5210204	Unusual parasitic vaginal infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		Increased susceptibility to parasitic vaginal infection, as manifested by recurrent or severe trichomoniasis or other parasitic vaginal infection. A common causative agent is Trichomonas vaginalis, which has been documented in immunocompromised hosts.
http://purl.obolibrary.org/obo/HP_5210205	Unusual bacterial osteomyelitis	http://purl.obolibrary.org/obo/HP_5210278	Unusual infectious osteomyelitis		An osteomyelitis caused by bacterial infection, with common causative organisms including Staphylococcus aureus, Streptococcus species, and gram-negative bacilli such as Salmonella and Serratia marcescens.
http://purl.obolibrary.org/obo/HP_5210278	Unusual infectious osteomyelitis	http://purl.obolibrary.org/obo/HP_5210277	Unusual musculoskeletal infection		Increased susceptibility to osteomyelitis of infectious aetiology, as manifested by recurrent or severe bone infection, multifocal osteomyelitis, or osteomyelitis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210206	Unusual fungal osteomyelitis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		An osteomyelitis caused by fungal infection, with causative organisms including Candida species, Aspergillus species, and the dimorphic fungi.
http://purl.obolibrary.org/obo/HP_5210207	Unusual infectious arthritis	http://purl.obolibrary.org/obo/HP_5210277	Unusual musculoskeletal infection		An increased susceptibility to arthritis of infectious etiology, as manifested by a recurrent or severe septic arthritis, or by an infectious arthritis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210277	Unusual musculoskeletal infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection of bones, joints, or muscles, as manifested by recurrent or severe osteomyelitis, septic arthritis, or infectious myositis, or by musculoskeletal infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210208	Unusual bacterial arthritis	http://purl.obolibrary.org/obo/HP_5210207	Unusual infectious arthritis		An arthritis caused by bacterial infection, with common causative organisms including Staphylococcus aureus, Streptococcus species, Neisseria gonorrhoeae, and Haemophilus influenzae.
http://purl.obolibrary.org/obo/HP_5210209	Unusual fungal arthritis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		An arthritis caused by fungal infection, with causative organisms including Candida species, Aspergillus species, and Cryptococcus.
http://purl.obolibrary.org/obo/HP_5210210	Unusual mycobacterial arthritis	http://purl.obolibrary.org/obo/HP_5210207	Unusual infectious arthritis		An arthritis caused by mycobacterial infection, with causative organisms including Mycobacterium tuberculosis (tuberculous arthritis) and non-tuberculous mycobacteria.
http://purl.obolibrary.org/obo/HP_5210211	Unusual infectious myositis	http://purl.obolibrary.org/obo/HP_5210277	Unusual musculoskeletal infection		An increased susceptibility to myositis of infectious aetiology, as manifested by a recurrent or severe inflammation of skeletal muscle caused by infection, or by an infectious myositis caused by an atypical or opportunistic organism. Common causative organisms include Staphylococcus aureus (pyomyositis), Streptococcus pyogenes, and Clostridium species (gas gangrene), as well as viral, fungal, and parasitic agents.
http://purl.obolibrary.org/obo/HP_5210212	Unusual bacterial myositis	http://purl.obolibrary.org/obo/HP_5210211	Unusual infectious myositis		A myositis caused by bacterial infection, with common causative organisms including Staphylococcus aureus (pyomyositis) and Streptococcus species.
http://purl.obolibrary.org/obo/HP_5210213	Unusual fungal myositis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		A myositis caused by fungal infection, with causative organisms including Candida species, Aspergillus species, and the Mucorales. A fungal myositis is rare and typically a manifestation of severe immunocompromise.
http://purl.obolibrary.org/obo/HP_5210214	Unusual mycobacterial myositis	http://purl.obolibrary.org/obo/HP_5210211	Unusual infectious myositis		A myositis caused by mycobacterial infection, with causative organisms including Mycobacterium tuberculosis and non-tuberculous mycobacteria.
http://purl.obolibrary.org/obo/HP_5210215	Unusual viral myositis	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A myositis caused by viral infection, with causative organisms including enterovirus, influenza virus, coxsackievirus, and HIV.
http://purl.obolibrary.org/obo/HP_5210218	Parasitic meningitis	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		A meningitis caused by parasitic infection, with causative organisms including Toxoplasma gondii, Acanthamoeba, and Naegleria fowleri. A parasitic meningitis can be a manifestation of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210219	Mycobacterial meningitis	http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection		A meningitis caused by mycobacterial infection, with the principal causative organism being Mycobacterium tuberculosis (tuberculous meningitis). A non-tuberculous mycobacterial meningitis is rare and can be a manifestation of unusual susceptibility to infection, particularly in Mendelian susceptibility to mycobacterial disease.
http://purl.obolibrary.org/obo/HP_5210220	Fungal encephalitis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		An encephalitis caused by fungal infection, with causative organisms including Cryptococcus neoformans, Aspergillus species, Candida species, and the Mucorales. A fungal encephalitis is most often a manifestation of disseminated invasive fungal disease in severely immunocompromised hosts.
http://purl.obolibrary.org/obo/HP_5210221	Parasitic encephalitis	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		An encephalitis caused by parasitic infection, with causative organisms including Toxoplasma gondii (toxoplasmic encephalitis), Acanthamoeba, and Naegleria fowleri. A parasitic encephalitis can be a manifestation of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210222	Mycobacterial encephalitis	http://purl.obolibrary.org/obo/HP_5210110	Unusual mycobacterial infection		An encephalitis caused by mycobacterial infection, with the principal causative organism being Mycobacterium tuberculosis (tuberculous encephalitis, often as part of CNS tuberculosis). A mycobacterial encephalitis can be a manifestation of unusual susceptibility to infection, particularly in Mendelian susceptibility to mycobacterial disease.
http://purl.obolibrary.org/obo/HP_5210223	Bacterial brain abscess	http://purl.obolibrary.org/obo/HP_0030049	Brain abscess		A brain abscess caused by bacterial infection, with causative organisms including Staphylococcus aureus, Streptococcus species, anaerobes, and gram-negative bacilli. It may arise from contiguous spread (sinusitis, otitis) or hematogenous seeding, and a bacterial brain abscess can be a manifestation of unusual susceptibility to infection, particularly in phagocyte defects.
http://purl.obolibrary.org/obo/HP_5210224	Fungal brain abscess	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		A brain abscess caused by fungal infection, with causative organisms including Aspergillus species, Cryptococcus, Candida, and the Mucorales. A fungal brain abscess is most often a manifestation of disseminated invasive fungal disease in severely immunocompromised hosts.
http://purl.obolibrary.org/obo/HP_5210225	Parasitic brain abscess	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		A brain abscess caused by parasitic infection, with causative organisms including Toxoplasma gondii, Entamoeba histolytica, and Echinococcus species. A parasitic brain abscess can be a manifestation of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210226	Mycobacterial brain abscess	http://purl.obolibrary.org/obo/HP_0030049	Brain abscess		A brain abscess caused by mycobacterial infection, with the classic manifestation being a tuberculoma caused by Mycobacterium tuberculosis. A mycobacterial brain abscess can be a manifestation of unusual susceptibility to infection, particularly in Mendelian susceptibility to mycobacterial disease.
http://purl.obolibrary.org/obo/HP_5210227	Unusual spinal cord infection	http://purl.obolibrary.org/obo/HP_0011450	Unusual CNS infection		Increased susceptibility to infection of the spinal cord, as manifested by infectious myelitis, spinal epidural or intradural abscess, or spinal cord compression due to infectious spondylodiscitis occuring in an unusual clinical context such as an atypical causative organism, absence of the usual predisposing factors, or by occurrence in the context of immune deficiency. Principal causative agents include bacteria (Staphylococcus aureus, Escherichia coli, Mycobacterium tuberculosis), fungi (Aspergillus species, Candida species), and viruses (enteroviruses, VZV, CMV).
http://purl.obolibrary.org/obo/HP_5210228	Unusual bacterial skin infection	http://purl.obolibrary.org/obo/HP_0032162	Unusual skin infection		An increased susceptibility to bacterial infection of the skin, as manifested by a recurrent or severe cutaneous bacterial infection, or by a skin infection caused by an atypical or opportunistic organism. Common causative organisms include Staphylococcus aureus and Streptococcus species. A recurrent bacterial skin infection can be a manifestation of phagocyte defects, hyper-IgE syndrome, and atopic dermatitis-related immune defects.
http://purl.obolibrary.org/obo/HP_5210229	Unusual bacterial skin abscess	http://purl.obolibrary.org/obo/HP_5210228	Unusual bacterial skin infection		Increased susceptibility to bacterial skin abscesses, as manifested by recurrent, multifocal, or unusually severe collections of pus within the dermis or deeper skin layers. While common causative organisms include Staphylococcus aureus and Streptococcus species, this term also encompasses abscesses caused by opportunistic or atypical bacteria, or those that are refractory to standard antibiotic therapy.
http://purl.obolibrary.org/obo/HP_5210230	Recurrent boils	http://purl.obolibrary.org/obo/HP_5210228	Unusual bacterial skin infection		A recurrent infection of hair follicles producing furuncles (boils), with common causative organisms being Staphylococcus aureus and Streptococcus species. A recurrent boil can be a manifestation of unusual susceptibility to infection, particularly in chronic granulomatous disease, hyper-IgE syndrome (STAT3 deficiency), leukocyte adhesion deficiency, and atopic dermatitis-related immune defects.
http://purl.obolibrary.org/obo/HP_5210231	Bacterial cellulitis	http://purl.obolibrary.org/obo/HP_5210228	Unusual bacterial skin infection		A cellulitis caused by bacterial infection of the dermis and subcutaneous tissue, with common causative organisms including Streptococcus pyogenes and Staphylococcus aureus.
http://purl.obolibrary.org/obo/HP_5210233	Unusual HSV skin infection	http://purl.obolibrary.org/obo/HP_5210232	Unusual viral skin infection		A herpes simplex virus (HSV) infection of the skin, which may present as localised vesicular lesions in any host. A severe, persistent, or disseminated cutaneous HSV infection (including eczema herpeticum and chronic ulcerative herpes) can be a manifestation of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210234	Unusual parasitic skin infection	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		An increased susceptibility to parasitic infection of the skin or subcutaneous tissue, as manifested by a recurrent, severe, or atypically distributed parasitic skin lesion, or by a cutaneous parasitic infection occurring in an unusual clinical context. Causative organisms include Leishmania species, Onchocerca volvulus, and Ancylostoma species. An atypical or disseminated cutaneous leishmaniasis can be a manifestation of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210235	Unusual VZV skin infection	http://purl.obolibrary.org/obo/HP_5210116	Unusual VZV infection		Varicella-zoster virus (VZV) skin infection including chickenpox or herpes zoster that is unusually severe or persistent.
http://purl.obolibrary.org/obo/HP_5210237	Recurrent diaper rash	http://purl.obolibrary.org/obo/HP_5210236	Unusual fungal skin infection		Recurrent nappy (diaper) rash of infectious aetiology, typically caused by Candida.
http://purl.obolibrary.org/obo/HP_5210239	Unusual bacterial nail bed infection	http://purl.obolibrary.org/obo/HP_5210228	Unusual bacterial skin infection		Increased susceptibility to bacterial infection of the nail bed and proximal nail fold (paronychia), as manifested by recurrent or severe episodes that are unusual in frequency or severity for a healthy individual of the same age. Principal causative agents include Staphylococcus aureus and Streptococcus species.
http://purl.obolibrary.org/obo/HP_5210241	Recurrent onychomycosis	http://purl.obolibrary.org/obo/HP_0012203	Unusual fungal nail infection		Increased susceptibility to recurrent fungal nail infection (onychomycosis), as manifested by recurrent or persistent infection of the nail plate, nail bed, or nail matrix caused by dermatophytes (Trichophyton species) or Candida species.
http://purl.obolibrary.org/obo/HP_5210242	Unusual mycobacterial skin infection	http://purl.obolibrary.org/obo/HP_0032162	Unusual skin infection		An increased susceptibility to mycobacterial infection of the skin, as manifested by persistent, disseminated, or multifocal cutaneous lesions occurring in an unusual clinical context. This includes skin involvement in tuberculosis (Mycobacterium tuberculosis) or infections caused by atypical mycobacteria (nontuberculous mycobacteria), such as M. marinum, M. avium complex, or M. chelonae.
http://purl.obolibrary.org/obo/HP_5210243	Unusual fascia infection	http://purl.obolibrary.org/obo/HP_5210277	Unusual musculoskeletal infection		Increased susceptibility to infection of the fascia and surrounding soft tissue, as manifested by necrotizing fasciitis or other invasive fascial infection occurring in an unusual clinical context. Necrotizing fasciitis is a rapidly progressive, life-threatening infection of the superficial fascia and subcutaneous tissue.
http://purl.obolibrary.org/obo/HP_5210244	Unusual cutaneous larva migrans	http://purl.obolibrary.org/obo/HP_5210234	Unusual parasitic skin infection		Infestation of the skin by migrating hookworm larvae (principally Ancylostoma braziliense and Ancylostoma caninum), causing serpiginous, pruritic, erythematous cutaneous tracks. Although typically self-limited in immunocompetent hosts, cutaneous larva migrans may follow a prolonged or atypical course in the context of immune deficiency, including HIV/AIDS and other T-cell defects.
http://purl.obolibrary.org/obo/HP_5210245	Unusual cutaneous leishmaniasis	http://purl.obolibrary.org/obo/HP_5210234	Unusual parasitic skin infection		Infection of the skin and subcutaneous tissue by Leishmania species, as manifested by cutaneous or mucocutaneous leishmaniasis occurring in the context of unusual susceptibility to infection. Cutaneous leishmaniasis presents with chronic, non-healing ulcerative skin lesions.
http://purl.obolibrary.org/obo/HP_5210246	Severe gingivitis	http://purl.obolibrary.org/obo/HP_0000230	Gingivitis		Increased susceptibility to gingivitis, as manifested by severe or necrotising gingival infection, including necrotising ulcerative gingivitis, associated with significant tissue destruction.
http://purl.obolibrary.org/obo/HP_5210247	Recurrent periodontitis	http://purl.obolibrary.org/obo/HP_0020341	Unusual periodontitis		Increased susceptibility to periodontitis, as manifested by recurrent or chronic periodontal infection that is unusual in frequency or severity for a healthy individual of the same age
http://purl.obolibrary.org/obo/HP_5210248	Severe dental abscess	http://purl.obolibrary.org/obo/HP_0030757	Tooth abscess		Increased susceptibility to dental abscess, as manifested by a severe or invasive dental abscess with systemic spread or requiring hospitalisation.
http://purl.obolibrary.org/obo/HP_5210249	Recurrent dental abscesses	http://purl.obolibrary.org/obo/HP_0030757	Tooth abscess		Increased susceptibility to dental abscess, as manifested by recurrent episodes of dental abscesses that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210250	Severe stomatitis	http://purl.obolibrary.org/obo/HP_0020342	Unusual stomatitis		Increased susceptibility to infectious stomatitis, as manifested by severe or invasive oral mucosal infection causing necrosis or aphthous ulceration of tissue, or requiring systemic antiviral or antimicrobial therapy.
http://purl.obolibrary.org/obo/HP_5210253	Severe oral thrush	http://purl.obolibrary.org/obo/HP_5210252	Unusual oral thrush		Increased susceptibility to oral candidiasis, as manifested by severe or invasive oropharyngeal infection with Candida albicans, including extension to the oesophagus or systemic spread.
http://purl.obolibrary.org/obo/HP_5210254	Severe pharyngitis	http://purl.obolibrary.org/obo/HP_0020343	Unusual pharyngitis		Increased susceptibility to pharyngitis, as manifested by a severe episode of pharyngeal infection requiring hospitalisation or intravenous antimicrobial therapy, or complicated by peritonsillar abscess, retropharyngeal abscess, or invasive spread.
http://purl.obolibrary.org/obo/HP_5210255	Severe otitis media	http://purl.obolibrary.org/obo/HP_0000388	Otitis media		Increased susceptibility to otitis media, as manifested by a severe episode of middle ear infection requiring hospitalisation, intravenous antibiotics, or surgical intervention, or complicated by mastoiditis, meningitis, or other invasive spread.
http://purl.obolibrary.org/obo/HP_5210256	Severe otitis externa	http://purl.obolibrary.org/obo/HP_0410017	Otitis externa		Increased susceptibility to otitis externa, as manifested by a severe or invasive infection of the external ear canal, including necrotising (malignant) otitis externa with involvement of surrounding bone or soft tissue.
http://purl.obolibrary.org/obo/HP_5210257	Recurrent otitis externa	http://purl.obolibrary.org/obo/HP_0410017	Otitis externa		Increased susceptibility to otitis externa, as manifested by recurrent episodes of infection of the external ear canal that are unusual in frequency or severity for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210258	Unusual conjunctivitis	http://purl.obolibrary.org/obo/HP_5210137	Unusual eye infection		Increased susceptibility to infectious conjunctivitis, as manifested by recurrent or severe infection of the conjunctiva, or by conjunctivitis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210259	Severe conjunctivitis	http://purl.obolibrary.org/obo/HP_5210258	Unusual conjunctivitis		Increased susceptibility to infectious conjunctivitis, as manifested by a severe episode with corneal involvement (keratoconjunctivitis), subepithelial infiltrates, or requiring systemic antiviral or antimicrobial therapy.
http://purl.obolibrary.org/obo/HP_5210260	Recurrent conjunctivitis	http://purl.obolibrary.org/obo/HP_5210258	Unusual conjunctivitis		Increased susceptibility to infectious conjunctivitis, as manifested by recurrent episodes of conjunctival infection that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210261	Unusual keratitis	http://purl.obolibrary.org/obo/HP_5210137	Unusual eye infection		Increased susceptibility to infectious keratitis, as manifested by recurrent or severe infection of the cornea, or by keratitis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210262	Severe keratitis	http://purl.obolibrary.org/obo/HP_5210261	Unusual keratitis		Increased susceptibility to infectious keratitis, as manifested by a severe episode of corneal infection with stromal involvement, corneal ulceration, perforation, or significant visual impairment.
http://purl.obolibrary.org/obo/HP_5210263	Recurrent keratitis	http://purl.obolibrary.org/obo/HP_5210261	Unusual keratitis		Increased susceptibility to infectious keratitis, as manifested by recurrent episodes of corneal infection that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210264	Unusual retinitis	http://purl.obolibrary.org/obo/HP_5210137	Unusual eye infection		Increased susceptibility to infectious retinitis, as manifested by recurrent or severe infection of the retina, or by retinitis caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210265	Severe retinitis	http://purl.obolibrary.org/obo/HP_5210264	Unusual retinitis		Increased susceptibility to infectious retinitis, as manifested by severe or extensive retinal infection with rapid progression, retinal detachment, or significant visual loss.
http://purl.obolibrary.org/obo/HP_5210266	Recurrent retinitis	http://purl.obolibrary.org/obo/HP_5210264	Unusual retinitis		Increased susceptibility to infectious retinitis, as manifested by recurrent episodes of retinal infection that are unusual in frequency for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_5210267	Family history of unusual infection	http://purl.obolibrary.org/obo/HP_0032316	Family history		A family history (in a first- or second-degree relative) of unusually severe, recurrent, or opportunistic infection.
http://purl.obolibrary.org/obo/HP_5210268	Family history of immune deficiency	http://purl.obolibrary.org/obo/HP_0032316	Family history		A family history (in a first- or second-degree relative) of an immune deficiency.
http://purl.obolibrary.org/obo/HP_5210269	Family history of autoimmunity	http://purl.obolibrary.org/obo/HP_0032316	Family history		A family history (in a first- or second-degree relative) of an autoimmune disease.
http://purl.obolibrary.org/obo/HP_5210270	Family history of death due to infection	http://purl.obolibrary.org/obo/HP_0032316	Family history		A family history of death of a first- or second-degree relative caused by infection.
http://purl.obolibrary.org/obo/HP_5210271	Family history of lymphoma	http://purl.obolibrary.org/obo/HP_0032317	Family history of cancer		A family history (in a first- or second-degree relative) of a lymphoma.
http://purl.obolibrary.org/obo/HP_5210272	Family history of leukaemia	http://purl.obolibrary.org/obo/HP_0032317	Family history of cancer		A family history (in a first- or second-degree relative) of a leukaemia.
http://purl.obolibrary.org/obo/HP_5210273	Maternal history of recurrent miscarriage	http://purl.obolibrary.org/obo/HP_0032316	Family history		A maternal history of recurrent miscarriage, defined as two or more pregnancy losses.
http://purl.obolibrary.org/obo/HP_5210274	Unexplained sibling death	http://purl.obolibrary.org/obo/HP_0032316	Family history		Death of a sibling that remains unexplained despite investigation, which may indicate an undiagnosed disease in the family.
http://purl.obolibrary.org/obo/HP_5210275	Consanguinity	http://purl.obolibrary.org/obo/HP_0032316	Family history		A reproductive relationship between two individuals who are related by blood as second cousins or closer. In a medical and genetic context, consanguinity increases the coefficient of inbreeding, raising the probability that an offspring will inherit identical alleles from a common ancestor (homozygosity by descent). This significantly increases the risk for autosomal recessive disorders, such as inborn errors of immunity, metabolic diseases, and rare neurodevelopmental syndromes. A history of consanguinity serves as a vital clinical marker for directing diagnostic investigations toward recessive genetic etiologies, especially in the presence of rare phenotypes or unexplained family medical history.
http://purl.obolibrary.org/obo/HP_5210279	Unusual lymphatic system infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection involving lymph nodes or lymphatic vessels, as manifested by recurrent or severe lymphadenitis or lymph node abscess, or by lymphatic infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_5210281	Post-vaccination mumps	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		Infection with attenuated mumps vaccine virus following mumps vaccination, occurring in the context of unusual susceptibility to live viral vaccines.
http://purl.obolibrary.org/obo/HP_5210282	Cytomegalovirus retinitis	http://purl.obolibrary.org/obo/HP_5210264	Unusual retinitis		Retinitis caused by cytomegalovirus (CMV) infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210283	Cytomegalovirus pneumonitis	http://purl.obolibrary.org/obo/HP_5210146	Unusual cytomegalovirus infection		Pneumonitis caused by cytomegalovirus (CMV) infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210284	Cytomegalovirus encephalitis	http://purl.obolibrary.org/obo/HP_5210146	Unusual cytomegalovirus infection		Encephalitis caused by cytomegalovirus (CMV) infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210288	EBV-driven HLH	http://purl.obolibrary.org/obo/HP_5210286	Unusual EBV infection		Haemophagocytic lymphohistiocytosis (HLH) triggered by Epstein-Barr virus infection.
http://purl.obolibrary.org/obo/HP_5210290	Disseminated herpes simplex virus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Disseminated infection with herpes simplex virus (HSV), involving multiple organ systems.
http://purl.obolibrary.org/obo/HP_5210291	Recurrent herpes simplex virus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to herpes simplex virus (HSV) infections as manifested by recurrent episodes of HSV infection.
http://purl.obolibrary.org/obo/HP_5210293	Persistent adenovirus viremia	http://purl.obolibrary.org/obo/HP_0032248	Persistent viremia		Persistent or recurrent detection of adenovirus in the blood that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210294	Adenovirus colitis	http://purl.obolibrary.org/obo/HP_5210182	Unusual viral colitis		Colitis caused by adenovirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210295	Adenovirus hepatitis	http://purl.obolibrary.org/obo/HP_5210101	Unusual adenovirus infection		Hepatitis caused by adenovirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210296	Adenovirus encephalitis	http://purl.obolibrary.org/obo/HP_5210101	Unusual adenovirus infection		Encephalitis caused by adenovirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210297	Adenovirus pneumonitis	http://purl.obolibrary.org/obo/HP_5210101	Unusual adenovirus infection		Pneumonitis caused by adenovirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210298	Recurrent chickenpox infection	http://purl.obolibrary.org/obo/HP_5210116	Unusual VZV infection		Increased susceptibility to varicella (chickenpox) infections as manifested by recurrent episodes of chickenpox infection.
http://purl.obolibrary.org/obo/HP_5210299	Severe chickenpox infection	http://purl.obolibrary.org/obo/HP_5210116	Unusual VZV infection		Increased susceptibility to varicella (chickenpox) infections as manifested by a severe or invasive infection with varicella (chickenpox).
http://purl.obolibrary.org/obo/HP_5210301	VZV encephalitis	http://purl.obolibrary.org/obo/HP_5210116	Unusual VZV infection		Encephalitis caused by varicella-zoster virus (VZV) infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210302	VZV pneumonitis	http://purl.obolibrary.org/obo/HP_5210116	Unusual VZV infection		Pneumonitis caused by varicella-zoster virus (VZV) infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210303	Unusual warts	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to human papillomavirus (HPV) causing warts infections as manifested by recurrent or severe/invasive infection with HPV causing warts, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210304	Disseminated warts	http://purl.obolibrary.org/obo/HP_5210303	Unusual warts		Increased susceptibility to human papillomavirus (HPV) manifested by unusually severe, extensive, or invasive warts.
http://purl.obolibrary.org/obo/HP_5210305	Recurrent warts	http://purl.obolibrary.org/obo/HP_5210303	Unusual warts		Increased susceptibility to human papillomavirus (HPV), manifested by recurrent episodes of warts.
http://purl.obolibrary.org/obo/HP_5210306	Chronic warts	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		Increased susceptibility to chronic or persistent human papillomavirus (HPV) infection causing warts that fail to clear over an extended period or recur after treatment that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210309	Persistent molluscum infection	http://purl.obolibrary.org/obo/HP_0032163	Unusual molluscum contagiosum		Increased susceptibility to Molluscum contagiosum infections as manifested by recurrent episodes of Molluscum contagiosum infection.
http://purl.obolibrary.org/obo/HP_5210312	Chronic norovirus infection	http://purl.obolibrary.org/obo/HP_5210310	Unusual norovirus infection		Increased susceptibility to chronic or persistent norovirus infection, as manifested by prolonged viral shedding and recurrent or unremitting gastrointestinal symptoms beyond the typical course of acute infection.
http://purl.obolibrary.org/obo/HP_5210313	Unusual Aichi virus hepatitis	http://purl.obolibrary.org/obo/HP_5210139	Infectious hepatitis		Hepatitis caused by Aichi virus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210314	Unusual enterovirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to enterovirus infections as manifested by recurrent or severe/invasive infection with enterovirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210315	Enteroviral central nervous system infection	http://purl.obolibrary.org/obo/HP_5210314	Unusual enterovirus infection		Infection of the central nervous system by enterovirus that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210316	Enteroviral sepsis	http://purl.obolibrary.org/obo/HP_0020071	Viremia		Sepsis or sepsis-like syndrome caused by enterovirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210317	Unusual astrovirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Increased susceptibility to astrovirus infections as manifested by recurrent or severe/invasive infection with astrovirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210318	Disseminated astrovirus infection	http://purl.obolibrary.org/obo/HP_0020071	Viremia		Disseminated infection with astrovirus involving organs beyond the gastrointestinal tract that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210319	Astrovirus central nervous system infection	http://purl.obolibrary.org/obo/HP_5210317	Unusual astrovirus infection		Infection of the central nervous system by astrovirus that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210321	Persitent influenza viremia	http://purl.obolibrary.org/obo/HP_0020071	Viremia		Persistent or recurrent detection of influenza virus in the blood or prolonged shedding in respiratory secretions that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210325	Recurrent parainfluenza virus infection	http://purl.obolibrary.org/obo/HP_5210323	Unusual parainfluenza infection		Increased susceptibility to parainfluenza virus infections as manifested by recurrent episodes of parainfluenza virus infection.
http://purl.obolibrary.org/obo/HP_5210326	Chronic SARS-CoV-2 infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A persistent SARS-CoV-2 infection with prolonged active viral replication and continuous detection of virus beyond the typical duration of acute COVID-19, typically lasting several weeks or longer, often with culturable virus and intra-host viral evolution. A chronic COVID-19 infection is distinct from post-acute sequelae of SARS-CoV-2 infection (long COVID), which represents a post-infectious syndrome after viral clearance, and from recurrent COVID-19 reinfections, which are common in the general population.
http://purl.obolibrary.org/obo/HP_5210328	Severe seasonal coronavirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A severe infection caused by a seasonal coronavirus (HCoV-229E, HCoV-OC43, HCoV-NL63, or HCoV-HKU1), characterized by lower respiratory tract involvement, hypoxia, or systemic illness beyond that typically seen with these viruses in immunocompetent hosts.
http://purl.obolibrary.org/obo/HP_5210329	Chronic seasonal coronavirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		A persistent infection with a seasonal coronavirus (HCoV-229E, HCoV-OC43, HCoV-NL63, or HCoV-HKU1) with prolonged active viral replication beyond the typical duration of acute infection.
http://purl.obolibrary.org/obo/HP_5210330	Unusual HHV6 infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		Increased susceptibility to human herpesvirus 6 (HHV-6) infections as manifested by recurrent or severe/invasive infection with HHV-6, or occurring in an unusual anatomical location, such as the brain.
http://purl.obolibrary.org/obo/HP_5210331	Unusual HHV8 infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		Increased susceptibility to human herpesvirus 8 (HHV-8) infections as manifested by recurrent or severe/invasive infection with HHV-8, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210332	BK virus nephropathy	http://purl.obolibrary.org/obo/HP_5210104	Unusual BK virus infection		Nephropathy caused by BK polyomavirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210333	BK virus encephalitis	http://purl.obolibrary.org/obo/HP_5210104	Unusual BK virus infection		Encephalitis caused by BK polyomavirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210334	Unusual JC virus infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		Increased susceptibility to JC polyomavirus infections as manifested by recurrent or severe/invasive infection with JC polyomavirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210335	JC nephropathy	http://purl.obolibrary.org/obo/HP_5210334	Unusual JC virus infection		Nephropathy caused by JC polyomavirus infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_5210336	JC encephalitis	http://purl.obolibrary.org/obo/HP_5210334	Unusual JC virus infection		Encephalitis caused by JC polyomavirus infection, typically presenting as progressive multifocal leukoencephalopathy (PML).
http://purl.obolibrary.org/obo/HP_5210337	Infectious granulomatosis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		Granulomatous inflammation with multiple granuloma formation attributable to a causative infectious agent, including bacteria, mycobacteria, fungi, or parasites.
http://purl.obolibrary.org/obo/HP_5210341	Granulomatous lymphocytic interstitial lung disease	http://purl.obolibrary.org/obo/HP_0033551	Non-necrotizing pulmonary granulomatosis		An interstitial lung disease, characterized by lymphocytic infiltration and/or granulomatous inflammation of the lung after exclusion of infection and alternative causes, often associated with multisystem inflammatory or granulomatous disease in patients with common variable immunodeficiency (CVID).
http://purl.obolibrary.org/obo/HP_5210342	Granulomatous lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Lymph node enlargement resulting from granulomatous inflammation, characterized by compact aggregates of epithelioid macrophages and giant cells within the lymph node parenchyma.
http://purl.obolibrary.org/obo/HP_5210343	Granuloma annulare	http://purl.obolibrary.org/obo/HP_5210338	Non-infectious granulomatosis		A non-infectious inflammatory granulomatous dermatosis characterized by annular or disseminated erythematous plaques resulting from palisading granulomas with central mucin deposition in the dermis.
http://purl.obolibrary.org/obo/HP_5210344	Granulomatous synovitis	http://purl.obolibrary.org/obo/HP_0100769	Synovitis		Inflammation of the synovial membrane characterized by granuloma formation within synovial tissue, consisting of aggregates of epithelioid histiocytes with or without multinucleated giant cells.
http://purl.obolibrary.org/obo/HP_5210345	Granulomatous uveitis	http://purl.obolibrary.org/obo/HP_0000554	Uveitis		Uveitis characterized by granulomatous inflammatory pattern of the uveal tract, with clinical findings that may include large keratic precipitates, iris nodules, or other signs of intraocular granulomatous inflammation.
http://purl.obolibrary.org/obo/HP_5210346	Granulomatous gingivitis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		Inflammation of the gingiva characterized by granulomatous tissue reaction, with compact aggregates of epithelioid histiocytes and multinucleate giant cells within the gingival lamina propria.
http://purl.obolibrary.org/obo/HP_5210347	Granulomatous iritis	http://purl.obolibrary.org/obo/HP_5210345	Granulomatous uveitis		Inflammation of the iris characterized by granulomatous tissue reaction, with compact aggregates of mononuclear phagocytes within the iris stroma.
http://purl.obolibrary.org/obo/HP_5210348	Unusual Burkholderia pseudomallei infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		An increased susceptibility to Burkholderia pseudomallei infections as manifested by a recurrent or severe/invasive infection with Burkholderia pseudomallei, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210349	Unusual coagulase-negative Staphylococcus infection	http://purl.obolibrary.org/obo/HP_5210001	Unusual gram-positive bacterial infection		An increased susceptibility to coagulase-negative staphylococci infections as manifested by a recurrent or severe/invasive infection with coagulase-negative staphylococci, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210350	Recurrent coagulase-negative Staphylococcus infection	http://purl.obolibrary.org/obo/HP_5210349	Unusual coagulase-negative Staphylococcus infection		An increased susceptibility to coagulase-negative staphylococci infections as manifested by recurrent episodes of coagulase-negative staphylococci infection.
http://purl.obolibrary.org/obo/HP_5210351	Severe coagulase-negative Staphylococcus infection	http://purl.obolibrary.org/obo/HP_5210349	Unusual coagulase-negative Staphylococcus infection		An increased susceptibility to coagulase-negative staphylococci infections as manifested by a severe or invasive infection with coagulase-negative staphylococci.
http://purl.obolibrary.org/obo/HP_5210352	Unusual Enterococcus faecalis infection	http://purl.obolibrary.org/obo/HP_5210006	Unusual Enterococcus infection		An increased susceptibility to Enterococcus faecalis infections as manifested by a recurrent or severe/invasive infection with Enterococcus faecalis, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210353	Recurrent Enterococcus faecalis infection	http://purl.obolibrary.org/obo/HP_5210352	Unusual Enterococcus faecalis infection		An increased susceptibility to Enterococcus faecalis infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210354	Severe Enterococcus faecalis infection	http://purl.obolibrary.org/obo/HP_5210352	Unusual Enterococcus faecalis infection		An increased susceptibility to Enterococcus faecalis infections as manifested by a severe or invasive infection with Enterococcus faecalis.
http://purl.obolibrary.org/obo/HP_5210355	Unusual Enterococcus faecium infection	http://purl.obolibrary.org/obo/HP_5210006	Unusual Enterococcus infection		An increased susceptibility to Enterococcus faecium infections as manifested by a recurrent or severe/invasive infection with Enterococcus faecium, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210356	Recurrent Enterococcus faecium infection	http://purl.obolibrary.org/obo/HP_5210355	Unusual Enterococcus faecium infection		An increased susceptibility to Enterococcus faecium infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210357	Severe Enterococcus faecium infection	http://purl.obolibrary.org/obo/HP_5210355	Unusual Enterococcus faecium infection		An increased susceptibility to Enterococcus faecium infections as manifested by a severe or invasive infection with Enterococcus faecium.
http://purl.obolibrary.org/obo/HP_5210358	Unusual Viridans Streptococci infection	http://purl.obolibrary.org/obo/HP_5210009	Unusual Streptococcus infection		An increased susceptibility to viridans group streptococci infections as manifested by a recurrent or severe/invasive infection with viridans group streptococci, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210359	Endocarditis caused by Streptococcus viridans infection	http://purl.obolibrary.org/obo/HP_5210358	Unusual Viridans Streptococci infection		An endocarditis caused by infection with viridans group streptococci, which are a characteristic causative agent of subacute bacterial endocarditis.
http://purl.obolibrary.org/obo/HP_5210360	Liver abscess due to Streptococcus viridans	http://purl.obolibrary.org/obo/HP_5210358	Unusual Viridans Streptococci infection		A liver abscess caused by infection with viridans group streptococci, which may arise from hematogenous spread, biliary infection, or contiguous spread.
http://purl.obolibrary.org/obo/HP_5210361	Unusual Mycobacterium abscessus infection	http://purl.obolibrary.org/obo/HP_5210115	Non-tuberculous mycobacterial infection		An increased susceptibility to Mycobacterium abscessus infections as manifested by a recurrent or severe/invasive infection with Mycobacterium abscessus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210362	Recurrent Mycobacterium abscessus infection	http://purl.obolibrary.org/obo/HP_5210361	Unusual Mycobacterium abscessus infection		An increased susceptibility to Mycobacterium abscessus infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210363	Severe Mycobacterium abscessus infection	http://purl.obolibrary.org/obo/HP_5210361	Unusual Mycobacterium abscessus infection		An increased susceptibility to Mycobacterium abscessus infections as manifested by a severe or invasive infection with Mycobacterium abscessus.
http://purl.obolibrary.org/obo/HP_5210364	Unusual Mycobacterium avium complex infection	http://purl.obolibrary.org/obo/HP_5210115	Non-tuberculous mycobacterial infection		An increased susceptibility to Mycobacterium avium complex infections as manifested by a recurrent or severe/invasive infection with Mycobacterium avium complex, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210365	Recurrent Mycobacterium avium complex infection	http://purl.obolibrary.org/obo/HP_5210364	Unusual Mycobacterium avium complex infection		An increased susceptibility to Mycobacterium avium complex infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210366	Severe Mycobacterium avium complex infection	http://purl.obolibrary.org/obo/HP_5210364	Unusual Mycobacterium avium complex infection		An increased susceptibility to Mycobacterium avium complex infections as manifested by a severe or invasive infection with Mycobacterium avium complex.
http://purl.obolibrary.org/obo/HP_5210367	Unusual Mycoplasma infection	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		An increased susceptibility to Mycoplasma infections as manifested by a recurrent or severe/invasive infection with Mycoplasma, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210368	Recurrent Mycoplasma infection	http://purl.obolibrary.org/obo/HP_5210367	Unusual Mycoplasma infection		An increased susceptibility to Mycoplasma infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210369	Severe Mycoplasma infection	http://purl.obolibrary.org/obo/HP_5210367	Unusual Mycoplasma infection		An increased susceptibility to Mycoplasma infections as manifested by a severe or invasive infection with Mycoplasma.
http://purl.obolibrary.org/obo/HP_5210370	Unusual Ureaplasma infection	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		An increased susceptibility to Ureaplasma infections as manifested by a recurrent or severe/invasive infection with Ureaplasma, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210371	Pulmonary cryptococcosis	http://purl.obolibrary.org/obo/HP_5210105	Unusual Cryptococcus infection		An infection of the lungs caused by Cryptococcus species, which is the most common entry portal for cryptococcal disease and may present as nodules, consolidation, or interstitial infiltrates.
http://purl.obolibrary.org/obo/HP_5210372	Cryptococcoma	http://purl.obolibrary.org/obo/HP_5210105	Unusual Cryptococcus infection		A granulomatous mass-like lesion caused by Cryptococcus infection, which may occur in the lung, brain, skin, or other organs.
http://purl.obolibrary.org/obo/HP_5210373	Unusual mucormycosis	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An increased susceptibility to Mucorales infections as manifested by a recurrent or severe/invasive infection with Mucorales, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210374	Unusual Talaromyces marneffei infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An increased susceptibility to Talaromyces marneffei infections as manifested by a recurrent or severe/invasive infection with Talaromyces marneffei, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210376	Recurrent dermatophyte infection	http://purl.obolibrary.org/obo/HP_5210375	Unusual dermatophyte infection		An increased susceptibility to dermatophytes infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210378	Unusual mold infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An increased susceptibility to mould infection, as manifested by a recurrent or severe invasive infection with filamentous fungi other than Aspergillus, or by a mould infection caused by an atypical or opportunistic organism. Common causative organisms include Fusarium species, Scedosporium species, and Lomentospora prolificans.
http://purl.obolibrary.org/obo/HP_5210379	Unusual Blastomyces dermatitidis infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An increased susceptibility to Blastomyces dermatitidis infections as manifested by a recurrent or severe/invasive infection with Blastomyces dermatitidis, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210380	Recurrent Blastomyces dermatitidis infection	http://purl.obolibrary.org/obo/HP_5210379	Unusual Blastomyces dermatitidis infection		An increased susceptibility to Blastomyces dermatitidis infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210381	Severe Blastomyces dermatitidis infection	http://purl.obolibrary.org/obo/HP_5210379	Unusual Blastomyces dermatitidis infection		An increased susceptibility to Blastomyces dermatitidis infections as manifested by a severe or invasive infection with Blastomyces dermatitidis.
http://purl.obolibrary.org/obo/HP_5210382	Unusual Coccidioides infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An increased susceptibility to Coccidioides infections as manifested by a recurrent or severe/invasive infection with Coccidioides, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210383	Recurrent Coccidioides infection	http://purl.obolibrary.org/obo/HP_5210382	Unusual Coccidioides infection		An increased susceptibility to Coccidioides infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210384	Severe Coccidioides infection	http://purl.obolibrary.org/obo/HP_5210382	Unusual Coccidioides infection		An increased susceptibility to Coccidioides infections as manifested by a severe or invasive infection with Coccidioides.
http://purl.obolibrary.org/obo/HP_5210385	Unusual Paracoccidioides brasiliensis infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An increased susceptibility to Paracoccidioides brasiliensis infections as manifested by a recurrent or severe/invasive infection with Paracoccidioides brasiliensis, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210386	Recurrent Paracoccidioides brasiliensis infection	http://purl.obolibrary.org/obo/HP_5210385	Unusual Paracoccidioides brasiliensis infection		An increased susceptibility to Paracoccidioides brasiliensis infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210387	Severe Paracoccidioides brasiliensis infection	http://purl.obolibrary.org/obo/HP_5210385	Unusual Paracoccidioides brasiliensis infection		An increased susceptibility to Paracoccidioides brasiliensis infections as manifested by a severe or invasive infection with Paracoccidioides brasiliensis.
http://purl.obolibrary.org/obo/HP_5210389	Recurrent Histoplasma capsulatum infection	http://purl.obolibrary.org/obo/HP_0032256	Unusual Histoplasma capsulatum infection		An increased susceptibility to Histoplasma capsulatum infections as manifested by recurrent episodes of infection with this pathogen.
http://purl.obolibrary.org/obo/HP_5210391	Unusual Candida auris infection	http://purl.obolibrary.org/obo/HP_5210102	Unusual Candida infection		An increased susceptibility to Candida auris infections as manifested by a recurrent or severe/invasive infection with Candida auris, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210392	Chronic Candida auris infection	http://purl.obolibrary.org/obo/HP_5210391	Unusual Candida auris infection		An increased susceptibility to chronic or persistent Candida auris infection, as manifested by prolonged infection with this multi-drug-resistant emerging Candida species.
http://purl.obolibrary.org/obo/HP_5210393	Severe Candida auris infection	http://purl.obolibrary.org/obo/HP_5210391	Unusual Candida auris infection		An increased susceptibility to Candida auris infections as manifested by a severe or invasive infection with Candida auris.
http://purl.obolibrary.org/obo/HP_5210394	HSV hepatitis	http://purl.obolibrary.org/obo/HP_5210240	Unusual HSV infection		A hepatitis caused by herpes simplex virus (HSV) infection, which may present as a severe or fulminant hepatitis with elevated transaminases, coagulopathy, and hepatic failure.
http://purl.obolibrary.org/obo/HP_5210395	VZV meningitis	http://purl.obolibrary.org/obo/HP_5210216	Viral meningitis		A meningitis caused by varicella-zoster virus (VZV) infection, which may occur as part of primary varicella, herpes zoster, or zoster sine herpete (without rash).
http://purl.obolibrary.org/obo/HP_5210396	Giant molluscum	http://purl.obolibrary.org/obo/HP_0032163	Unusual molluscum contagiosum		A molluscum contagiosum lesion exceeding one centimetre in diameter, which may present as an unusually large, persistent, or atypical lesion.
http://purl.obolibrary.org/obo/HP_5210397	Unusual HHV7 infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		An increased susceptibility to human herpesvirus 7 (HHV-7) infections as manifested by a recurrent or severe/invasive infection with HHV-7, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210398	BK virus cystitis	http://purl.obolibrary.org/obo/HP_5210192	Unusual hemorrhagic cystitis		A cystitis caused by BK polyomavirus infection, typically presenting as haemorrhagic cystitis with macroscopic haematuria.
http://purl.obolibrary.org/obo/HP_5210399	Unusual poliovirus infection	http://purl.obolibrary.org/obo/HP_5210314	Unusual enterovirus infection		An increased susceptibility to poliovirus infections as manifested by a recurrent or severe/invasive infection with poliovirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210400	Chronic poliovirus excretion	http://purl.obolibrary.org/obo/HP_5210399	Unusual poliovirus infection		A chronic shedding of poliovirus in stool over an extended period, typically following vaccination with live attenuated oral poliovirus vaccine, with viral excretion persisting for months or years. A chronic poliovirus excretion is characteristic of antibody deficiencies including X-linked agammaglobulinaemia and common variable immunodeficiency, in which patients may shed vaccine-derived poliovirus indefinitely.
http://purl.obolibrary.org/obo/HP_5210401	Severe rotavirus infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		An increased susceptibility to rotavirus infections as manifested by a recurrent or severe/invasive infection with rotavirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210402	Unusual respiratory syncytial virus infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		An increased susceptibility to respiratory syncytial virus (RSV) infections as manifested by a recurrent or severe/invasive infection with RSV, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210403	Severe respiratory syncytial virus infection	http://purl.obolibrary.org/obo/HP_5210402	Unusual respiratory syncytial virus infection		An increased susceptibility to respiratory syncytial virus (RSV) infections as manifested by a severe or invasive infection with respiratory syncytial virus (RSV).
http://purl.obolibrary.org/obo/HP_5210404	Chronic respiratory syncytial virus infection	http://purl.obolibrary.org/obo/HP_5210402	Unusual respiratory syncytial virus infection		An increased susceptibility to chronic or persistent respiratory syncytial virus (RSV) infection, as manifested by prolonged viral shedding and persistent or recurrent respiratory symptoms beyond the typical course of acute infection.
http://purl.obolibrary.org/obo/HP_5210405	Chronic rhinovirus infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		An increased susceptibility to rhinovirus infections as manifested by a recurrent or severe/invasive infection with rhinovirus, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210406	Unusual human metapneumovirus infection	http://purl.obolibrary.org/obo/HP_0033432	Opportunistic viral infection		An increased susceptibility to human metapneumovirus (hMPV) infections as manifested by a recurrent or severe/invasive infection with hMPV, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_5210407	Toxoplasma eye infection	http://purl.obolibrary.org/obo/HP_5210137	Unusual eye infection		An ocular infection caused by Toxoplasma gondii, typically presenting as chorioretinitis with characteristic retinal lesions and potential progression to vision loss.
http://purl.obolibrary.org/obo/HP_6001466	Elevated circulating somatostatin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of somatostatin in the blood corculation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001467	Lack of attached gingiva	http://purl.obolibrary.org/obo/HP_0000168	Abnormality of the gingiva		Absence of attached gingiva. The gingiva is subdivided into the nonattached free gingiva (which includes the gingival margin and the papillae) and the attached gingiva. The attached gingiva is tightly and unmovably bound to the periosteum via collagen type I fibers. The gingiva is keratinized and thicker than the mucosa to provide mechanical protection. The border between attached gingiva and mucosa constitutes the mucogingival junction. In vivo, it is sometimes visible as a white line . The oral mucosa is loosely connected to the periosteum and nonkeratinized. It is movable, thin, more fragile, translucent, and blood vessels are visible.
http://purl.obolibrary.org/obo/HP_6001468	Spontaneous diaphragmatic rupture	http://purl.obolibrary.org/obo/HP_0000775	Abnormality of the diaphragm		A full thickness tear of the diaphragm without significant trauma.
http://purl.obolibrary.org/obo/HP_6001469	Elevated alveolar-arterial (A-a) oxygen gradient	http://purl.obolibrary.org/obo/HP_0500165	Abnormal blood oxygen level		An increase in the difference between the oxygen concentration in the alveoli and arterial system above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001470	Abnormal concentration of circulating metanephrines	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Adrenaline, noradrenaline and dopamine are degraded by catechol-O-methyltransferase (COMT) to form their inactive metabolites metanephrine, normetanephrine and 3-methoxytyramine (3-MT). When there is an indication for biochemical testing, such as suspicion of pheochromocytoma, metanephrine and normetanephrine metabolites are measured in plasma or 24-hour urine. This term represents an elevation of the concentration of metanephrine and normetanephrine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001471	Elevated circulating 3-O-methyldopa concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of 3-O-methyldopa in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001472	Elevated CSF 3-O-methyldopa concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of 3-O-methyldopa in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001473	Fixed fetal head flexion	http://purl.obolibrary.org/obo/HP_0034245	Fetal head anomaly		An unchanging bending forward of the fetal head in the uterus as visualized by prenatal sonography. This sign can be defined as a lack of change in this position during the 30 min of observation. Additionally, identical head flexion is observable several times at intervals.
http://purl.obolibrary.org/obo/HP_6001474	Abnormal rectosigmoid index	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		The rectosigmoid (R/S) ratio, a measure comparing rectal to sigmoid colon diameter, is below the lower limit of normal on prenatal ultrasound. The rectosigmoid is normally the widest segment of the fetal colon. If the rectosigmoid is narrower than the ascending or transverse colon above it), this is called a reversed rectosigmoid ratio or abnormal rectosigmoid index. The RS ratio is calculated by dividing the transverse rectal diameter by the sigmoid diameter. An R/S ratio of 1 or more is considered normal.
http://purl.obolibrary.org/obo/HP_6001475	Umbilical cord edema	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Visible edema (swelling) in a cord with a minimal cross sectional area of 1-3 cm2. This may result from an excessive accumulation of Wharton jelly, resulting in a thick or edematous umbilical cord.
http://purl.obolibrary.org/obo/HP_6001476	Fetal enterolithiasis	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Enterolithiasis (concretions or stones forming within the gastrointestinal tract) is a prenatal sonographic sign defined by hyperechogenic foci within the - often distended - fetal bowel.
http://purl.obolibrary.org/obo/HP_6001477	Malignant cells in CSF	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		The identification of malignant cells in cerebrospinal fluid (CSF), generally by microscopic examination of the CSF.
http://purl.obolibrary.org/obo/HP_6001478	Greek warrior helmet sign	http://purl.obolibrary.org/obo/HP_0034245	Fetal head anomaly		A prenatal sonographic finding characterized by a high forehead, prominent glabella, and a broad, un-tapered nasal bridge that merges directly into the brow line. This appearance is said to resemble a Greek (Corinthian) warrior helmet because the wide, solid vertical column down the center of the face is said to resemble the fixed, protective nose guard of a Corinthian helmet.
http://purl.obolibrary.org/obo/HP_6001479	Somatostatinoma	http://purl.obolibrary.org/obo/HP_0100634	Neuroendocrine neoplasm		Somatostatinoma is a rare, functional neuroendocrine tumor (NET) that primarily arises in the pancreas and duodenum, characterized by excessive production of somatostatin.
http://purl.obolibrary.org/obo/UBERON_0016514	cavity of left ventricle	http://purl.obolibrary.org/obo/UBERON_0035763	cavity of cardiac chamber		Luminal space of the left ventricle of the heart.
http://purl.obolibrary.org/obo/CL_0002323	amniocyte	http://purl.obolibrary.org/obo/CL_0000349	extraembryonic cell		A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface.
http://purl.obolibrary.org/obo/HP_0009189	Fragmented metacarpal epiphysis	http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology		Fragmented appearance of the epiphyses of the metacarpals.
http://purl.obolibrary.org/obo/UBERON_0005872	1st arch pharyngeal cleft	http://purl.obolibrary.org/obo/UBERON_0005879	pharyngeal cleft		A groove that is situated between the 1st and 2nd pharyngeal arch.
http://purl.obolibrary.org/obo/UBERON_0007831	pectoral girdle skeleton	http://purl.obolibrary.org/obo/UBERON_0010719	girdle skeleton		A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons.
http://purl.obolibrary.org/obo/GO_0061983	meiosis II cell cycle process	http://purl.obolibrary.org/obo/GO_1903046	meiotic cell cycle process		A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes.
http://purl.obolibrary.org/obo/CHEBI_139588	alpha-hydroxy ketone	http://purl.obolibrary.org/obo/CHEBI_17087	ketone		A ketone containing a hydroxy group on the α-carbon relative to the C=O group.
http://purl.obolibrary.org/obo/CHEBI_139590	primary alpha-hydroxy ketone	http://purl.obolibrary.org/obo/CHEBI_139588	alpha-hydroxy ketone		An α-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a -CH<small><sub>2</sub></small> (methylene) group.
http://purl.obolibrary.org/obo/CHEBI_140601	fatty acid 4:0	http://purl.obolibrary.org/obo/CHEBI_26666	short-chain fatty acid		Any saturated fatty acid containing 4 carbons.
http://purl.obolibrary.org/obo/HP_0020117	Hypoplastic dermoepidermal hemidesmosomes	http://purl.obolibrary.org/obo/HP_0032449	Abnormal dermoepidermal hemidesmosome morphology		Underdeveloped hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin.
http://purl.obolibrary.org/obo/HP_0020118	Radial artery aplasia	http://purl.obolibrary.org/obo/HP_0031640	Abnormal radial artery morphology		Congenital absence of the radial artery.
http://purl.obolibrary.org/obo/HP_0020119	Abnormal retinal nerve fiber layer morphology	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		A structural abnormality of the retinal nerve fiber layer
http://purl.obolibrary.org/obo/HP_0020120	Retinal nerve fiber edema	http://purl.obolibrary.org/obo/HP_0020119	Abnormal retinal nerve fiber layer morphology		Swelling (edema) of the retinal nerve fibers.
http://purl.obolibrary.org/obo/HP_0020121	Conception by assisted reproductive technology	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A history of conception by an assisted reproductive technology such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and cryopreservation.
http://purl.obolibrary.org/obo/HP_0020122	Bite cells	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		Red blood cells that appear to have parts of them bitten away.
http://purl.obolibrary.org/obo/HP_0020123	Tympanosclerosis	http://purl.obolibrary.org/obo/HP_0008609	Abnormal middle ear morphology		A stiffening of the tympanic membrane due to calcification, typically presents as white plaque-like lesions, involving discrete regions of the tympanic membrane and/or middle ear.
http://purl.obolibrary.org/obo/HP_0020125	Spontaneous conjunctival filtering bleb	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Avascular cystic elevations of the superior conjunctiva not related to ocular surgery or trauma.
http://purl.obolibrary.org/obo/HP_0020126	Prostate mass	http://purl.obolibrary.org/obo/HP_0008775	Abnormal prostate morphology		A lump detected in the prostate. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction.
http://purl.obolibrary.org/obo/HP_0020127	Periarticular soft-tissue mass	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		A lump detected in the region that surrounds a joint. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction.
http://purl.obolibrary.org/obo/HP_0020128	Aplasia of the olfactory tract	http://purl.obolibrary.org/obo/HP_0100547	Abnormal forebrain morphology		Aplasia (congenital absence) of the olfactory tract, which causes anosmia, a complete loss of the sense of smell.
http://purl.obolibrary.org/obo/HP_0020130	Increased urinary neutrophil gelatinase-associated lipocalin	http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level		An increased concentration of neutrophil gelatinase-associated lipocalin in the urine (there is no generally accepted threshold, but some studies choose a threshold of above 150 nanogram per milliliter).
http://purl.obolibrary.org/obo/HP_0020132	Thickening of the tubular basement membrane	http://purl.obolibrary.org/obo/HP_0020131	Abnormal tubular basement membrane morphology		Increase in thickness of the basement membrane of the tubulus of the kidney.
http://purl.obolibrary.org/obo/HP_0020133	Podocyte hypertrophy	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Increased visceral epithelial cell size, with or without cytoplasmic protein droplets.
http://purl.obolibrary.org/obo/HP_0020134	Increased urine neutrophil count	http://purl.obolibrary.org/obo/HP_0012085	Pyuria		Abnormally increased count of neutrophils in urine.
http://purl.obolibrary.org/obo/HP_0020135	Myofibromatosis	http://purl.obolibrary.org/obo/HP_0031459	Soft tissue neoplasm		A mesenchymal neoplasm characterized by solitary or multiple nodules involving the skin, striated muscles, bones and, sometimes, viscera. It usually appears as a subcutaneous nodule, but can also appear as an ulcer, pedunculated lesion, or similar to a hemangioma. Histology shows well-circumscribed tapered cell lobes, resembling smooth muscle cells. At its center, perivascular round cells (hemangiopericitoides) are usually observed, giving a biphasic appearance.
http://purl.obolibrary.org/obo/HP_0020136	Anticardiolipin IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0003613	Antiphospholipid antibody positivity		The presence of circulating IgG autoantibodies to cardiolipin.
http://purl.obolibrary.org/obo/HP_0020137	Anticardiolipin IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0003613	Antiphospholipid antibody positivity		The presence of circulating IgM autoantibodies to cardiolipin.
http://purl.obolibrary.org/obo/HP_0020138	History of recent animal bite	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of a recent bite injury due to an animal.
http://purl.obolibrary.org/obo/HP_0020139	History of recent insect bite	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of a recent bite injury due to an insect.
http://purl.obolibrary.org/obo/HP_0020140	History of recent tick bite	http://purl.obolibrary.org/obo/HP_0020139	History of recent insect bite		Medical history of a recent bite injury due to a tick.
http://purl.obolibrary.org/obo/HP_0020141	Blood pressure substantially higher in legs than arms	http://purl.obolibrary.org/obo/HP_0030972	Abnormal systemic blood pressure		An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the legs being much higher than the blood pressure measure in the arms. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm.
http://purl.obolibrary.org/obo/HP_0020142	Blood pressure substantially higher in arms than legs	http://purl.obolibrary.org/obo/HP_0030972	Abnormal systemic blood pressure		An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the arms being much higher than the blood pressure measure in the legs. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm.
http://purl.obolibrary.org/obo/HP_0020143	Tracheal duplication cyst	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		A cyst in the trachea, whose wall is made up by tissue similar to the bronchial tree, including cartilage and smooth muscle, and is lined by secretory respiratory epithelium composed of cuboid or columnar ciliated epithelium.
http://purl.obolibrary.org/obo/HP_0020144	Calcium phosphate crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		The presence of calcium phosphate crystals in the urine.
http://purl.obolibrary.org/obo/HP_0020145	Calcium oxalate crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		The presence of calcium oxalate crystals in the urine.
http://purl.obolibrary.org/obo/HP_0020146	Calcium carbonate crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		The presence of calcium carbonate crystals in the urine.
http://purl.obolibrary.org/obo/HP_0020147	2-Methylbutyryl glycinuria	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		Increased concentration of 2-methylbutyryl glycine in the urine.
http://purl.obolibrary.org/obo/HP_0020148	Increased circulating mead acid level	http://purl.obolibrary.org/obo/HP_0003455	Elevated circulating long chain fatty acid concentration		An abnormally elevated concentration od mead acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020149	Elevated circulating succinate	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		An increase concentration of succinate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020150	Elevated urinary uromodulin level	http://purl.obolibrary.org/obo/HP_0034885	Abnormal urinary uromodulin level		The concentration of uromodulin (also known as Tamm Horsfall protein) in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020151	Anti-dsDNA antibody positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against double-stranded DNA.
http://purl.obolibrary.org/obo/HP_0020152	Distal joint hypermobility	http://purl.obolibrary.org/obo/HP_0430046	Small joint hypermobility		Lack of stability of a distal joint (e.g., finger).
http://purl.obolibrary.org/obo/HP_0020153	Positive blood 1,3 beta glucan test	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Beta-1,3-glucan is a major constituent of all of the characterized fungal cell walls, making up between 30-80 percent of the mass of the wall. It is a biomarker of fungal infections such as invasive pulmonary aspergillosis.
http://purl.obolibrary.org/obo/HP_0020154	Nevus comedonicus	http://purl.obolibrary.org/obo/HP_0010816	Epidermal nevus		A type of epidermal nevus characterized by closely arranged, dilated follicular openings with keratinous plugs resembling classical comedones.
http://purl.obolibrary.org/obo/HP_0020155	Abnormal oocyte morphology	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		An abnormal structure of the female germ cell (egg cell).
http://purl.obolibrary.org/obo/HP_0020156	Abnormal zona pellucida morphology	http://purl.obolibrary.org/obo/HP_0020155	Abnormal oocyte morphology		Abnormal structure of the oocyte extracellular matrix region known as the zona pellucida.
http://purl.obolibrary.org/obo/HP_0020157	Thin zona pellucida	http://purl.obolibrary.org/obo/HP_0020156	Abnormal zona pellucida morphology		Reduced thickness of the zona pellucida.
http://purl.obolibrary.org/obo/HP_0020158	Increased circulating adrenic acid concentration	http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration		An increased concentration of adrenic acid (also known as cis-7,10,13,16-Docosatetraenoic acid) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020159	Reduced response to gonadotropin-releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0031279	Abnormal response to gonadotropin-releasing hormone stimulation test		Failure of the gonadotropin-releasing hormone (GnRH) stimulation test to induce an appropriate increased in luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels.
http://purl.obolibrary.org/obo/HP_0020160	GM1-ganglioside accumulation	http://purl.obolibrary.org/obo/HP_0004345	Ganglioside accumulation		Cellular accumulation of GM1 gangliosides.
http://purl.obolibrary.org/obo/HP_0020161	Branch retinal artery occlusion	http://purl.obolibrary.org/obo/HP_0025326	Retinal arterial occlusion		Blockage of a branch of the retinal artery. This can cause loss of a section of visual field.
http://purl.obolibrary.org/obo/HP_0020163	Cilioretinal arteriolar hypoperfusion	http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology		Ischemia in the territory of the cilioretinal artery causing opacification of the inner retina and visual loss. This is most commonly seen in central retinal vein occlusion in the young.
http://purl.obolibrary.org/obo/HP_0020164	Ophthalmic artery occlusion	http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology		Acute complete obstruction of the ophthalmic artery (branch of the internal carotid artery) that may lead to severe ischemia of the affected globe and associated ocular tissues. It can present with a similar picture to central retinal artery occlusion associated with choroidal ischemia.
http://purl.obolibrary.org/obo/HP_0020165	Branch retinal vein occlusion	http://purl.obolibrary.org/obo/HP_0012636	Retinal venous occlusion		Blockage of a branch of the retinal vein. It may present with sudden-onset of painless vision loss or visual field defect correlating to the area of perfusion of the obstructed vessels.
http://purl.obolibrary.org/obo/HP_0020166	Central retinal vein occlusion	http://purl.obolibrary.org/obo/HP_0012636	Retinal venous occlusion		Central retinal vein occlusion is an occlusion of the main retinal vein posterior to the lamina cribrosa of the optic nerve and is typically caused by thrombosis.
http://purl.obolibrary.org/obo/HP_0020167	Hemiretinal vein occlusion	http://purl.obolibrary.org/obo/HP_0012636	Retinal venous occlusion		A variant of central retinal vein occlusions that involves the superior or inferior half of the retina.
http://purl.obolibrary.org/obo/HP_0020169	Abnormal drug response	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		An anomalous response to a medication related to individual variation in metabolic or immune response to drugs varying from potentially from potentially life-threatening adverse drug reactions to alteration of therapeutic efficacy.
http://purl.obolibrary.org/obo/HP_0020170	Increased blood drug concentration	http://purl.obolibrary.org/obo/HP_0020169	Abnormal drug response		High plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime.
http://purl.obolibrary.org/obo/HP_0020171	Decreased blood drug concentration	http://purl.obolibrary.org/obo/HP_0020169	Abnormal drug response		Low plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime.
http://purl.obolibrary.org/obo/HP_0020172	Adverse drug response	http://purl.obolibrary.org/obo/HP_0020169	Abnormal drug response		An unpleasant or harmful reaction resulting from treatment with a drug.
http://purl.obolibrary.org/obo/HP_0020173	Reduced drug efficacy	http://purl.obolibrary.org/obo/HP_0020169	Abnormal drug response		Decreased response to a drug intervention in comparison to the expected response.
http://purl.obolibrary.org/obo/HP_0020174	Refractory drug response	http://purl.obolibrary.org/obo/HP_0020169	Abnormal drug response		Absent or significantly reduced efficacy of drug intervention characterized by lack of measurable benefit or deterioration of disease course.
http://purl.obolibrary.org/obo/HP_0020175	Reduced circulating cholinesterase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity or concentration of cholinesterase in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0020176	Cholesterol crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		The presence of cholesterol crystals in the urine.
http://purl.obolibrary.org/obo/HP_0020177	Abnormal CD8+ TEMRA T cell proportion	http://purl.obolibrary.org/obo/HP_0410380	Abnormal memory CD8+ T cell proportion		An abnormal proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.
http://purl.obolibrary.org/obo/HP_0020178	Abnormal dendritic cell count	http://purl.obolibrary.org/obo/HP_0011893	Abnormal leukocyte count		A deviation from the normal count of dendritic cells in the peripheral blood circulation. Dendritic cells are of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).
http://purl.obolibrary.org/obo/HP_0020179	Abnormal circulating haptoglobin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of haptoglobin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020180	Elevated circulating haptoglobin concentration	http://purl.obolibrary.org/obo/HP_0020179	Abnormal circulating haptoglobin concentration		The concentration of haptoglobin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020181	Decreased circulating haptoglobin concentration	http://purl.obolibrary.org/obo/HP_0020179	Abnormal circulating haptoglobin concentration		The concentration of haptoglobin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0020182	Abnormal circulating A-type atrial natriuretic peptide concentration	http://purl.obolibrary.org/obo/HP_6000692	Abnormal circulating proANP concentration		A measurable change in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.
http://purl.obolibrary.org/obo/HP_0020183	Increased circulating A-type natriuretic peptide concentration	http://purl.obolibrary.org/obo/HP_0020182	Abnormal circulating A-type atrial natriuretic peptide concentration		A measurable elevation in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.
http://purl.obolibrary.org/obo/HP_0020184	Decreased circulating A-type natriuretic peptide concentration	http://purl.obolibrary.org/obo/HP_0020182	Abnormal circulating A-type atrial natriuretic peptide concentration		A measurable reduction in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.
http://purl.obolibrary.org/obo/HP_0020185	Superior cerebellar dysplasia	http://purl.obolibrary.org/obo/HP_0007033	Cerebellar dysplasia		Abnormal morphological development of the superior part of the cerebellum.
http://purl.obolibrary.org/obo/HP_0020186	Multilobulated spleen	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		The fetal spleen is lobulated, and these lobules normally disappear before the birth. Lobulation of the spleen may persist into adult life and be typically seen along the medial part of the spleen. A persisting lobule results in a variation in shape of the spleen.
http://purl.obolibrary.org/obo/HP_0020187	Thick pachygyria	http://purl.obolibrary.org/obo/HP_0001302	Pachygyria		Pachygyria with a very thick cerebral cortex measuring 10-20 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age.
http://purl.obolibrary.org/obo/HP_0020188	Anterior predominant pachygyria with 5-10 mm cortical thickness	http://purl.obolibrary.org/obo/HP_0020192	Pachygyria with 5-10 mm cortical thickness		Pachygyria with cortical thickness between 5 and 10 mm with and a posterior predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically over 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.
http://purl.obolibrary.org/obo/HP_0020189	Posterior predominant thick cortex pachygyria	http://purl.obolibrary.org/obo/HP_0020187	Thick pachygyria		Pachygyria with cortical thickness above 10 mm with and a posterior predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.
http://purl.obolibrary.org/obo/HP_0020190	Perisylvian predominant thick cortex pachygyria	http://purl.obolibrary.org/obo/HP_0020187	Thick pachygyria		Pachygyria with cortical thickness greater than 10 mm and a perisylvian predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Perisylvian predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.
http://purl.obolibrary.org/obo/HP_0020191	Anterior predominant thick cortex pachygyria	http://purl.obolibrary.org/obo/HP_0020187	Thick pachygyria		Pachygyria with cortical thickness greater than 10 mm and an anterior predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Anterior predominant gradient indicates pachygyria more severe over the frontal and temporal lobes.
http://purl.obolibrary.org/obo/HP_0020192	Pachygyria with 5-10 mm cortical thickness	http://purl.obolibrary.org/obo/HP_0001302	Pachygyria		Pachygyria with a mildly thickened cerebral cortex measuring 5-10 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age.
http://purl.obolibrary.org/obo/HP_0020193	Prolonged reptilase time	http://purl.obolibrary.org/obo/HP_0001928	Abnormality of coagulation		An abnormally increased duration of the reptilase time. Reptilase time is a functional plasma clotting assay, which is based on the enzymatic activity of batroxobin. By specifically cleaving fibrinogen A from fibrinogen, batroxobin leads to the formation of a stable fibrin clot. The time, starting from the addition of batroxobin to the plasma sample, until clot formation is the reptilase time and is given in seconds.
http://purl.obolibrary.org/obo/HP_0020194	IgA heavy chain paraproteinemia	http://purl.obolibrary.org/obo/HP_0031049	Heavy-chain paraproteinemia		An abnormal IgA heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.
http://purl.obolibrary.org/obo/HP_0020195	IgG heavy chain paraproteinemia	http://purl.obolibrary.org/obo/HP_0031049	Heavy-chain paraproteinemia		An abnormal IgG heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.
http://purl.obolibrary.org/obo/HP_0020196	IgM heavy chain paraproteinemia	http://purl.obolibrary.org/obo/HP_0031049	Heavy-chain paraproteinemia		An abnormal IgM heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.
http://purl.obolibrary.org/obo/HP_0020197	Increased circulating arachidonic acid concentration	http://purl.obolibrary.org/obo/HP_0010964	Abnormal circulating long-chain fatty-acid concentration		An increased circulation of arachidonic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020198	Abnormal circulating 18-hydroxycorticosterone level	http://purl.obolibrary.org/obo/HP_0012112	Abnormal circulating corticosterone level		Any deviation from the normal concentration of 18-Hydroxycorticosterone level in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020199	Decreased circulating 18-hydroxycortisone level	http://purl.obolibrary.org/obo/HP_0020198	Abnormal circulating 18-hydroxycorticosterone level		A subnormal concentration of 18-Hydroxycorticosterone level in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020200	Increased circulating 18-hydroxycortisone level	http://purl.obolibrary.org/obo/HP_0020198	Abnormal circulating 18-hydroxycorticosterone level		An abnormally elevated concentration of 18-Hydroxycorticosterone level in the blood circulation.
http://purl.obolibrary.org/obo/HP_0020201	Abnormal sarcomere morphology	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Any structural anomaly of the sarcomere, which is unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z disks.
http://purl.obolibrary.org/obo/HP_0020202	Abnormal Z disk morphology	http://purl.obolibrary.org/obo/HP_0020201	Abnormal sarcomere morphology		Any structural anomaly of the Z disk, which is the platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
http://purl.obolibrary.org/obo/HP_0020203	Z-band streaming	http://purl.obolibrary.org/obo/HP_0020202	Abnormal Z disk morphology		Streaming or smearing of the Z band, which is then no longer confined to a narrow zone which bisects the I band. The Z disk may extend across the I band or the entire sarcomere in a zigzag manner. Focal thickening, smudging, and blurring of the Z band takes place concurrently. Myofibrillar disorganization is a frequent but not invariable accompanying change.
http://purl.obolibrary.org/obo/HP_0020204	Tubulointerstitial bacterial infiltration	http://purl.obolibrary.org/obo/HP_0032635	Tubulointerstitial microganismal infiltration		Tubulointerstitial infiltration of bacteria identified on routine and/or special (Brown-Hopps) stains.
http://purl.obolibrary.org/obo/HP_0020205	Tubulointerstitial fungal infiltration	http://purl.obolibrary.org/obo/HP_0032635	Tubulointerstitial microganismal infiltration		Tubulointerstitial infiltration of yeast or hyphal-microrganisms identified on routine and/or special (PAS, silver) stains.
http://purl.obolibrary.org/obo/HP_0020206	Simple ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		The pinna has fewer folds and grooves than usual.
http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		Seizures precipitated by exogenous stimuli.
http://purl.obolibrary.org/obo/HP_0020208	Eating-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		A seizure precipitated by aspects of anticipating food, eating itself, or the post-prandial period.
http://purl.obolibrary.org/obo/HP_0020209	Hot water-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		A seizure precipitated by pouring cupfuls of very hot water (40 to 50 degrees Celsius) in rapid succession over the head. Bathing in this manner is the most common trigger.
http://purl.obolibrary.org/obo/HP_0020210	Praxis-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		A seizure precipitated by complex, cognition-guided tasks often involving visuomotor coordination and decision-making.
http://purl.obolibrary.org/obo/HP_0020211	Proprioceptive-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		A seizure precipitated by movement or a change in posture.
http://purl.obolibrary.org/obo/HP_0020212	Reading-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		A seizure precipitated by reading.
http://purl.obolibrary.org/obo/HP_0020213	Somatosensory-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		A somatosensory reflex seizure is a seizure precipitated by somatic stimulation of a specific part of the body in the absence of startle or surprise.
http://purl.obolibrary.org/obo/HP_0020214	Startle-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		Startle-induced seizures are triggered by multiple and non-specific stimuli (auditory, somatosensory, and rarely visual) and are characterized by their sudden unexpected nature. Sudden noise rather than pure sound is the most effective acoustic stimulus.
http://purl.obolibrary.org/obo/HP_0020215	Thinking-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		Seizures induced by thinking and decision-making.
http://purl.obolibrary.org/obo/HP_0020216	Visually-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		Seizures evoked by visual stimuli. This includes clinical seizures induced by strobe lighting, television and other screens, flickering environmental lighting and self-induction by causing a strobe effect.
http://purl.obolibrary.org/obo/HP_0020217	Focal aware motor seizure	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A type of focal motor seizure in which awareness is retained throughout the seizure.
http://purl.obolibrary.org/obo/HP_0020218	Focal aware atonic seizure	http://purl.obolibrary.org/obo/HP_0020220	Focal atonic seizure		A type of focal atonic seizure during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0020220	Focal atonic seizure	http://purl.obolibrary.org/obo/HP_0010819	Atonic seizure		A focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature.
http://purl.obolibrary.org/obo/HP_0032570	Pontine ischemic lacunes	http://purl.obolibrary.org/obo/HP_0032325	Lacunar stroke		Lacunes are infarcts less than 15 mm in diameter in the cortical white matter or in the corona radiata, internal capsule, centrum semiovale, thalamus, basal ganglia, or pons.
http://purl.obolibrary.org/obo/HP_0032571	Increased oocyte death	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An increase in death of oocytes, the female germ cell (egg cell), which can be observed clinically in the setting of in vitro fertilization.
http://purl.obolibrary.org/obo/HP_0032573	Elevated urinary cytidine	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		Increased levels of urinary cytidine, a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N1 glycosidic bond.
http://purl.obolibrary.org/obo/HP_0032574	Elevated urinary uridine level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		Increased levels of urinary uridine, a ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N1 glycosidic bond.
http://purl.obolibrary.org/obo/HP_0032575	Decreased circulating 12-HETE	http://purl.obolibrary.org/obo/HP_0011022	Abnormal circulating unsaturated fatty acid concentration		A reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid.
http://purl.obolibrary.org/obo/HP_0032576	Intracellular accumulation of Dol-PP-GlcNAc2Man5	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		Intracellular accumulation of the lipid-linked oligosaccharide intermediate Man5GlcNAc2-PP-dolichol.
http://purl.obolibrary.org/obo/HP_0032577	Clonal T cell receptor rearrangement	http://purl.obolibrary.org/obo/HP_0025845	Abnormal TCR repertoire		Presence of a predominant T cell clone. In PCR-based assays, this finding is inferred on the basis of one or two prominent bands within a valid size range. In NGS-based assays, this finding is inferred on the basis of a high number of reads that map to a single T cell receptor clone.
http://purl.obolibrary.org/obo/HP_0032578	Third ventricle colloid cyst	http://purl.obolibrary.org/obo/HP_0010951	Abnormal third ventricle morphology		An epithelial lined cyst filled with gelatinous material. The gelatinous material commonly contains mucin, old blood, cholesterol, and ions. Most colloid cysts identified are currently asymptomatic and identified incidentally on imaging. When a colloid cyst does cause issues, it most commonly causes obstructive hydrocephalus.
http://purl.obolibrary.org/obo/HP_0032579	Vascular hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A benign focal growth composed of vascular tissue.
http://purl.obolibrary.org/obo/HP_0032580	Abnormal bulbus cordis morphology	http://purl.obolibrary.org/obo/HP_0001627	Abnormal heart morphology		Abnormal structure of the bulbus cordis, which is the single outflow tract of the heart during early embryogenesis.
http://purl.obolibrary.org/obo/HP_0032582	Renal interstitial foam cells	http://purl.obolibrary.org/obo/HP_0003651	Foam cells		Accumulation of foam cells (FC) in the interstitium of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles.
http://purl.obolibrary.org/obo/HP_0032584	Renal interstitial neutrophil infiltration	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Increased numbers of neutrophils in the interstitial tissues of the kidney.
http://purl.obolibrary.org/obo/HP_0032585	Renal interstitial eosinophil infiltration	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Increased numbers of eosinophils in the interstitial tissues of the kidney.
http://purl.obolibrary.org/obo/HP_0032586	Renal interstitial plasma cell infiltration	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Increased numbers of plasma cells in the interstitial tissues of the kidney.
http://purl.obolibrary.org/obo/HP_0032587	Renal interstitial calcium oxalate	http://purl.obolibrary.org/obo/HP_0008672	Calcium oxalate nephrolithiasis		The presence of birefringent calcium- and oxalate deposits in interstitial cells of the kidney.
http://purl.obolibrary.org/obo/HP_0032588	Hand apraxia	http://purl.obolibrary.org/obo/HP_0002186	Apraxia		Inability to perform purposeful (learned) movements with the hand upon command, even though the command is understood and there is a willingness to perform the movement. Hand apraxia includes the inability to grasp, pick up, and hold large and small objects.
http://purl.obolibrary.org/obo/HP_0032589	Renal lymphocytic tubulitis	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Infiltration of the renal tubular epithelium by lymphocytes.
http://purl.obolibrary.org/obo/HP_0032590	Renal neutrophilic tubulitis	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Infiltration of the renal tubular epithelium by neutrophils.
http://purl.obolibrary.org/obo/HP_0032591	Renal interstitial hemosiderin	http://purl.obolibrary.org/obo/HP_0032644	Renal interstitial deposits		Deposition of hemosiderin (a golden-brown, granular pigment derived from ferritin) in interstitial cells of the kidney.
http://purl.obolibrary.org/obo/HP_0032592	Aplasia of the right hemidiaphragm	http://purl.obolibrary.org/obo/HP_0040047	Abnormal right hemidiaphragm morphology		Congenital absence of the right-sided diaphragm.
http://purl.obolibrary.org/obo/HP_0032593	Myoglobin casts	http://purl.obolibrary.org/obo/HP_0031199	Acellular urinary casts		A type of acelluar casts with positive myoglobin staining A that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented.
http://purl.obolibrary.org/obo/HP_0032594	Renal tubular basement membrane denudation	http://purl.obolibrary.org/obo/HP_0020131	Abnormal tubular basement membrane morphology		Naked basement membranes without tubular epithelium.
http://purl.obolibrary.org/obo/HP_0032595	Renal tubular epithelial cell detachment	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved.
http://purl.obolibrary.org/obo/HP_0032596	Renal tubular epithelial cell cytoplasmic vacuolization	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size.
http://purl.obolibrary.org/obo/HP_0032597	Renal tubular epithelial cell sloughing	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		At least one free floating cell in the tubular lumen without attachment to adjacent cells or basement membrane in a tubular cross section without detachment. These cells must not aggregate into a tubular shape and completely fill the lumen, if so, it should be classified as a cast.
http://purl.obolibrary.org/obo/HP_0032598	Blebbing of apical cytoplasm of renal tubular epithelial cells	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular cross section with round/irregular cytoplasmic protrusion, shaped like the Greek capital letter Omega (or it may be more vertically elongated Omega), pinched off from apical membrane without apparent closure of the lumen, involving over 50 percent of the tubular cells in cross section. The feature can be further classified into proximal or distal tubule.
http://purl.obolibrary.org/obo/HP_0032600	Renal tubular epithelial cell hyaline droplets	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell.
http://purl.obolibrary.org/obo/HP_0032601	Multinucleation of renal tubular epithelial cells	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular epithelial cells with greater than 3 nuclei in a single epithelial cell, often overlapping with each other in a single plane of view.
http://purl.obolibrary.org/obo/HP_0032602	Prominent nucleoli of renal tubular epithelial cells	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular epithelium with nucleoli clearly visible at 100-fold magnification.
http://purl.obolibrary.org/obo/HP_0032603	Renal tubular epithelial cell simplification	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular cross section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush border involving greater than 50 percent of the tubular cells in cross section, resulting in an apparent increase in the size of the lumen, without the presence of casts.
http://purl.obolibrary.org/obo/HP_0032604	Renal tubular epithelial cell mitosis	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular epithelial cells in any mitotic phase, identified by distinctively visible chromosome in either prophase, metaphase, anaphase or telophase configuration.
http://purl.obolibrary.org/obo/HP_0032605	High renal tubular epithelial cell N/C ratio	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		At least one tubular epithelial cell with average sized cytoplasmic area and a nuclear area 3 times greater than average sized nuclei.
http://purl.obolibrary.org/obo/HP_0032606	Renal tubular epithelial lipofuscin	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Presence of increased amount of lipofuscin, a yellow, granular cytoplasmic pigment in the renal tubules.
http://purl.obolibrary.org/obo/HP_0032607	Renal tubular epithelial cell swelling	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular cross section lined entirely by tubular epithelium with convex apical cell membrane (i.e., cells are shaped like an upside down U, and lack a distinct smaller protrusion seen in blebbing as defined above) resulting in apparent complete closure of the lumen.
http://purl.obolibrary.org/obo/HP_0032608	Thyroidization-type tubular atrophy	http://purl.obolibrary.org/obo/HP_0000092	Renal tubular atrophy		A type of renal tubular atrophy characterized by a thyroid-like appearance, with small round tubules with markedly flattened, simplified epithelium and uniform intratubular casts.
http://purl.obolibrary.org/obo/HP_0032609	Endocrine-type tubular atrophy	http://purl.obolibrary.org/obo/HP_0000092	Renal tubular atrophy		A type of renal tubular atrophy characterized by endocrine-like appearance of tubules, which are small and have narrow lumina, clear cells, and relatively thin basement membranes.
http://purl.obolibrary.org/obo/HP_0032610	Tubulointerstitial mycobacterial infiltration	http://purl.obolibrary.org/obo/HP_0032635	Tubulointerstitial microganismal infiltration		Renal tubulointerstitial infiltration of mycobacteria identified on acid-fast or Fite stains. Can be associated with granulomatous inflammation.
http://purl.obolibrary.org/obo/HP_0032611	Renal tubular epithelial cell hemosiderin	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Tubular epithelial cells containing cytoplasmic hemosiderin, brown-golden granular pigment.
http://purl.obolibrary.org/obo/HP_0032612	Triphalangeal hallux	http://purl.obolibrary.org/obo/HP_0010057	Abnormal hallux phalanx morphology		A hallux (big toe) with three phalanges in a single, proximo-distal axis.
http://purl.obolibrary.org/obo/HP_0032613	Renal interstitial amyloid deposits	http://purl.obolibrary.org/obo/HP_0032644	Renal interstitial deposits		Deposition of amyloid in the interstitial tissue of the kidney. Amyloid is is made up of 10 nm (on average) fibrils that are most commonly composed of monoclonal light chains (AL), transthyretin (TTR), amd LECT2, or occur in the setting of long standing systemic inflammation.
http://purl.obolibrary.org/obo/HP_0032614	Renal glomerular amyloid deposition	http://purl.obolibrary.org/obo/HP_0001917	Renal amyloidosis		Amyloid deposits located in the glomeruli in a focal segmental, diffuse segmental or diffuse global fashion. This abnormality can be accompanied by mesangial involvement and in later stages also involvement of the peripheral capillaries.
http://purl.obolibrary.org/obo/HP_0032615	Abnormal diffusion weighted cerebral MRI morphology	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		A diffusion abnormality observed in diffusion-weighted magnetic resonance imaging (MRI) of the brain. Molecular diffusion refers to the notion that any type of molecule in a fluid (eg, water) is randomly displaced as the molecule is agitated by thermal energy. Restricted diffusion of water appears bright on diffusion-weighted images.
http://purl.obolibrary.org/obo/HP_0032616	Renal interstitial immunoglobulin deposits	http://purl.obolibrary.org/obo/HP_0032644	Renal interstitial deposits		Accumulation of an immunoglobulin in the interstitial tissue of the kidney. The immunoglobulin may be a monoclonal Ig or the corresponding heavy-chain (HC) or light-chain (LC) subunit. By convention this definition excludes Ig-derived amyloidosis (amyloidosis can be distinguished by its affinity for Congo red staining).
http://purl.obolibrary.org/obo/HP_0032617	Renal interstitial hemorrhage	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core.
http://purl.obolibrary.org/obo/HP_0032619	Perinephric abscess	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		A perinephric abscess is a collection of suppurative material in the perinephric space (i.e., the connective and adipose tissues surrounding the kidney).
http://purl.obolibrary.org/obo/HP_0032620	Intrarenal abscess	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		An encapsulated collection of pus and necrotic material within the renal parenchyma. The destruction of renal parenchyma is associated with suppurative/neutrophil-rich inflammation and necrosis.
http://purl.obolibrary.org/obo/HP_0032621	Hyperchromasia of renal tubular epithelial cells	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		At least one tubular cross section with all tubular epithelial nuclei having a chromatin pattern resembling normal mature lymphocytes.
http://purl.obolibrary.org/obo/HP_0032622	Tubular luminal dilatation	http://purl.obolibrary.org/obo/HP_0032950	Abnormal renal tubular lumen morphology		Dilatation (expansion beyond the normal dimension) of the cavity (lumen) of tubules of the kidney. The tubular cross section displays an attenuated brush border (apical PAS positivity greater than 10 percent of the normal expected height, but unequivocally less than normal expected height), resulting in an apparent increase in the size of lumen.
http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. This term refers to casts located within the tubuli of the kidney. More precisely, casts are defined as a material that completely fills and expands the tubular lumen with simplification of surrounding tubular epithelium. Casts are classified as either nuclear debris/granular brown material, red blood cell, white blood cell, myeloma, or myoglobin cast.
http://purl.obolibrary.org/obo/HP_0032624	Intratubular bilirubin casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. On H&E (red brown), PAS (amaranth purple), trichrome (red with ragged contours), Hall (olive-emerald green).
http://purl.obolibrary.org/obo/HP_0032625	Intratubular erythrocyte cast	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		Casts that contain red blood cells and are located within the tubuli of the kidney.
http://purl.obolibrary.org/obo/HP_0032626	Intratubular vancomycin casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		Intratubular casts composed of vancomycin aggregates and uromodulin.
http://purl.obolibrary.org/obo/HP_0032627	Intratubular leukocyte casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		Casts that contain white blood cells and are located within the tubuli of the kidney.
http://purl.obolibrary.org/obo/HP_0032629	Intratubular dihydroxyadenuria crystals	http://purl.obolibrary.org/obo/HP_0032628	Renal intratubular crystals		Intratubular crystals composed of 2,8-dihydroxyadenine are small needle-shaped brownish crystals that are highly birefringent under polarized light and black by Jones methenamine silver.
http://purl.obolibrary.org/obo/HP_0032630	Intratubular light-chain casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		The presence of casts containing immunoglobulin light chains within the lumina of the renal tubules.
http://purl.obolibrary.org/obo/HP_0032631	Intratubular hemoglobin casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented. On H&E (red granular), PAS (purple), trichrome (red granular), Hall (yellow brown). Stain positively for Hemoglobin A.
http://purl.obolibrary.org/obo/HP_0032632	Renal papillary necrosis	http://purl.obolibrary.org/obo/HP_0032618	Renal necrosis		Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei.
http://purl.obolibrary.org/obo/HP_0032633	Intratubular hyaline casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		A type of acellular urinary cast located within the distal tubules of the kidney and that is composed only of Tamm-Horsfall glycoprotein. Correspondingly, these casts have a low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends.
http://purl.obolibrary.org/obo/HP_0032634	Intratubular myoglobin cast	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		Casts located within the tubuli of the kidney and that contain myoglobin. Myoglobin casts are composed of round granules that may line up in chains or aggregate in clusters. Their color ranges from pink to red-brown with hematoxylin and eosin stain, light brown to black with Jones methenamine silver stain, pink to bright magenta with periodic acid-Schiff stain, and bright red with trichrome stain. Immunoperoxidase staining with antibody to myoglobin is stronglypositive in the casts.Electron microscopy shows globular casts with an electron-dense core and a somewhat less-intense periphery. Substructure is absent. This feature may be accompanied by acute tubular injury with variable flattening of tubular epithelial cells, loss of brush borders, and intratubular sloughed epithelial cells.
http://purl.obolibrary.org/obo/HP_0032635	Tubulointerstitial microganismal infiltration	http://purl.obolibrary.org/obo/HP_0001969	Abnormal tubulointerstitial morphology		Infiltration of microorganisms into renal tubulointerstitial tissues as observed by appropriate staining procedures, e.g., bacteria on a bacterial stain (Brown and Hopps) or fungi on PAS or silver stain.
http://purl.obolibrary.org/obo/HP_0032636	Tubulointerstitial viral infiltration	http://purl.obolibrary.org/obo/HP_0001969	Abnormal tubulointerstitial morphology		Infiltration of viruses into renal tubulointerstitial tissues as demonstrated on renal biopsy by viral inclusions which can be seen on routine stains or with immunohistochemistry.
http://purl.obolibrary.org/obo/HP_0032637	Renal interstitial edema	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Edema is characterized but the acute swelling of the stroma, with expansion of the interstitial space without the a concurrent increase in interstitial cells or extracellular matrix. Histologically this change is appreciated as interstitial areas of lower optical density.
http://purl.obolibrary.org/obo/HP_0032638	Elevated urine mevalonic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An abnormally increased amount of mevanolate in the urine. Mevanolate is that hydroxy monocarboxylic acid anion that is the conjugate base of mevalonic acid.
http://purl.obolibrary.org/obo/HP_0032639	Elevated leukocyte cystine	http://purl.obolibrary.org/obo/HP_0003358	Elevated intracellular cystine		An increased concentration of cystine within white blood cells.
http://purl.obolibrary.org/obo/HP_0032640	Elevated circulating CCL18 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of CCL18 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032641	Renal interstitial granulomas	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present.
http://purl.obolibrary.org/obo/HP_0032642	Renal interstitial necrotizing granulomas	http://purl.obolibrary.org/obo/HP_0032641	Renal interstitial granulomas		An organized collection of histiocytes (specifically macrophages) localized in the interstitial tissue of the kidney. Through light microscopy, the activated histiocytes appear as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells. Granulomas may be associated with a peripheral cuff of lymphoplasmacytic and occasionally eosinophilic inflammation. Organization can range from poorly-to-well defined. Granulomas can present as necrotizing or non-necrotizing. Microscopically, necrotizing granulomas distinctly have central necrosis with a palisaded lymphohistiocytic reaction and a cuff of chronic inflammation.
http://purl.obolibrary.org/obo/HP_0032643	Renal interstitial non-necrotizing granulomas	http://purl.obolibrary.org/obo/HP_0032641	Renal interstitial granulomas		Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present with no necrosis.
http://purl.obolibrary.org/obo/HP_0032644	Renal interstitial deposits	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney.
http://purl.obolibrary.org/obo/HP_0032645	Renal interstitial mononuclear cell infiltration	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Presence of interstitial mononuclear leukocytes, i.e., white blood ceclls with a single round nucleus, including lymphocytes and monocytes but not including granulocytes (which have multilobed nuclei).
http://purl.obolibrary.org/obo/HP_0032646	Renal interstitial xanthogranulomatous inflammation	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Inflammation of interstitial tissues of the kidney consisting of foamy macrophages admixed with plasma cells, lymphocytes and neutrophils and occasional giant cells.
http://purl.obolibrary.org/obo/HP_0032647	Renal tubular epithelial cell apoptosis	http://purl.obolibrary.org/obo/HP_0032599	Abnormal renal tubular epithelial morphology		Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells are rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris.
http://purl.obolibrary.org/obo/HP_0032648	Tubularization of Bowman capsule	http://purl.obolibrary.org/obo/HP_0031264	Abnormal Bowman capsule morphology		The presence of cuboidal to columnar epithelium (height greater than width) lining the Bowman capsule, in an absence of adjacent segmental sclerosis, crescents, or collapsing variant of focal segmental glomerulosclerosis; scored as present or absent in at least one glomerulus.
http://purl.obolibrary.org/obo/HP_0032649	Skewfoot	http://purl.obolibrary.org/obo/HP_0001763	Pes planus		A type of flat-foot characterized by hindfoot abductovalgus, metatarsus adductus, and Achilles tendon shortening. The predominant radiographic findings include forefoot adduction with lateral subluxation of the navicular on the talus and heel valgus. Very abnormal shoe wear is noted on the medial side. Calluses occur under the metatarsal heads and the head of the plantar-flexed talus.
http://purl.obolibrary.org/obo/HP_0032650	Elevated CSF glial fibrillary acidic protein concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Increased concentration of glial fibrillary acidic protein in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0032651	Elevated CSF chitinase-3-like protein 1 concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Increased concentration of chitinase-3-like protein 1 in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0032652	Elevated CSF chitotriosidase 1 concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Increased concentration of chitotriosidase 1 in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0032653	Elevated lactate:pyruvate ratio	http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis		An abnormal increase in the molar ratio of lactate to pyruvate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032654	Impaired flow-mediated arterial dilatation	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Flow-mediated dilatation is a noninvasive tests of endothelial function that leverages ultrasound to measure arterial diameter and its response to an increase in shear stress, which normally causes endothelium-dependent dilatation. This term pertains to an abnormal reduction in the magnitude of dilatation. Flow-mediated dilatation is usually measured at the brachial artery.
http://purl.obolibrary.org/obo/HP_0032655	Decreased adipose tissue tocopherol level	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		A reduced concentration of tocopherol in fat tissue.
http://purl.obolibrary.org/obo/HP_0032656	Febrile status epilepticus	http://purl.obolibrary.org/obo/HP_0011172	Complex febrile seizure		A seizure lasting 30 minutes without fully regaining consciousness, provoked by fever (temperature greater than 38.0 degrees Celcius) at the time of seizure-onset, without a prior history of afebrile seizure and with no evidence of an acute central nervous system infection or insult.
http://purl.obolibrary.org/obo/HP_0032657	Elevated circulating lyso-globotriaosylsphingosine concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		An abnormal increase in the level of globotriaosylsphingosine (Lyso-Gb3) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032658	Status epilepticus with prominent motor symptoms	http://purl.obolibrary.org/obo/HP_0002133	Status epilepticus		Status epilepticus with prominent motor signs during the prolonged seizure.
http://purl.obolibrary.org/obo/HP_0032659	Non-convulsive status epilepticus with coma	http://purl.obolibrary.org/obo/HP_0031475	Status epilepticus without prominent motor symptoms		A type of status epilepticus without prominent motor symptoms and in the presence of coma.
http://purl.obolibrary.org/obo/HP_0032660	Convulsive status epilepticus	http://purl.obolibrary.org/obo/HP_0032658	Status epilepticus with prominent motor symptoms		A type of status epilepticus characterized by a prolonged bilateral tonic-clonic seizure, or repeated bilateral tonic-clonic seizures without recovery between.
http://purl.obolibrary.org/obo/HP_0032661	Generalized convulsive status epilepticus	http://purl.obolibrary.org/obo/HP_0025190	Bilateral tonic-clonic seizure with generalized onset		A type of bilateral convulsive seizure of generalized onset that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus.
http://purl.obolibrary.org/obo/HP_0032662	Focal-onset seizure evolving into bilateral convulsive status epilepticus	http://purl.obolibrary.org/obo/HP_0032660	Convulsive status epilepticus		A type of bilateral convulsive seizure of focal onset (which could be with awareness or impaired awareness, either motor or non- motor) that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus.
http://purl.obolibrary.org/obo/HP_0032664	Adversive status epilepticus	http://purl.obolibrary.org/obo/HP_0032663	Focal motor status epilepticus		A type of focal motor status epilepticus characterized by continuous neck or body rotation and conjugate gaze deviation in a direction contralateral to the responsible epileptic focus. This includes some forms of tonic status epilepticus.
http://purl.obolibrary.org/obo/HP_0032665	Repeated focal motor seizures	http://purl.obolibrary.org/obo/HP_0032663	Focal motor status epilepticus		A type of focal motor status epilepticus characterized by repeated motor, typically clonic events repeatedly affecting the same segments of the body with spread of clonic movements through contiguous body parts unilaterally, and repeating over a sufficiently prolonged period to reach a diagnosis of status epilepticus.
http://purl.obolibrary.org/obo/HP_0032666	Hyperkinetic status epilepticus	http://purl.obolibrary.org/obo/HP_0032658	Status epilepticus with prominent motor symptoms		Status epilepticus characterized by continuous hyperkinetic proximal limb or axial muscles producing irregular sequential ballistic movements such as pedaling pelvic thrusting, thrashing, or rocking movements.
http://purl.obolibrary.org/obo/HP_0032667	Myoclonic status epilepticus	http://purl.obolibrary.org/obo/HP_0032658	Status epilepticus with prominent motor symptoms		A type of motor status epilepticus with repeating bilateral sudden brief (less than 100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography.
http://purl.obolibrary.org/obo/HP_0032668	Myoclonic status epilepticus without coma	http://purl.obolibrary.org/obo/HP_0032667	Myoclonic status epilepticus		A type of myoclonic status epilepticus in the absence of coma.
http://purl.obolibrary.org/obo/HP_0032669	Myoclonic status epilepticus with coma	http://purl.obolibrary.org/obo/HP_0032667	Myoclonic status epilepticus		A type of myoclonic status epilepticus in the presence of coma.
http://purl.obolibrary.org/obo/HP_0032670	Tonic status epilepticus	http://purl.obolibrary.org/obo/HP_0032658	Status epilepticus with prominent motor symptoms		Tonic status epilepticus is a type of status epilepticus characterized by focal or bilateral limb stiffening or elevation, which may be electrographically generalized or focal.
http://purl.obolibrary.org/obo/HP_0032671	Non-convulsive status epilepticus without coma	http://purl.obolibrary.org/obo/HP_0031475	Status epilepticus without prominent motor symptoms		A type of status epilepticus without prominent motor symptoms in the absence of coma.
http://purl.obolibrary.org/obo/HP_0032672	Autonomic status epilepticus	http://purl.obolibrary.org/obo/HP_0032671	Non-convulsive status epilepticus without coma		Autonomic status epilepticus is a type of non-convulsive status epilepticus without coma with prominent autonomic features regardless of whether it is electrographically generalized or focal.
http://purl.obolibrary.org/obo/HP_0032673	Focal non-convulsive status epilepticus without coma	http://purl.obolibrary.org/obo/HP_0032671	Non-convulsive status epilepticus without coma		Focal non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically focal. It is a prolonged focal non-motor seizure.
http://purl.obolibrary.org/obo/HP_0032674	Cutaneous wound	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		A cutaneous wound is a defined as a disruption of normal anatomic structure and function of the skin that occurs owing to an injury of the skin. Wound healing is a dynamic, interactive process involving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. Wound healing has three phases: inflammation, tissue formation, and tissue remodeling, that overlap in time.
http://purl.obolibrary.org/obo/HP_0032675	Acute cutaneous wound	http://purl.obolibrary.org/obo/HP_0032674	Cutaneous wound		A cutaneous wound that is proceeding through an orderly and timely reparative process that results in sustained restoration of the anatomic and functional integrity of the skin.
http://purl.obolibrary.org/obo/HP_0032676	Chronic cutaneous wound	http://purl.obolibrary.org/obo/HP_0032674	Cutaneous wound		A cutaneous wound that has failed to proceed through the orderly and timely process to produce an atomic and functional integrity, or proceeded through the repair process without establishing a sustained anatomic and functional result.
http://purl.obolibrary.org/obo/HP_0041050	Renal tubular cyst	http://purl.obolibrary.org/obo/HP_0000107	Renal cyst		Tubular lumnal dilatation/prominence lined by simple layer of cuboidal-to-flat tublar epihelial cells.
http://purl.obolibrary.org/obo/GO_0120316	sperm flagellum assembly	http://purl.obolibrary.org/obo/GO_0044458	motile cilium assembly		The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium).
http://purl.obolibrary.org/obo/CL_0009038	colon macrophage	http://purl.obolibrary.org/obo/CL_0000235	macrophage		A macrophage that is located in the colon.
http://purl.obolibrary.org/obo/HsapDv_0000260	nursing stage (0-11 months)	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Human developmental stage that covers the first period from birth, with breast feeding and/or bottled substitute, and that stops at language acquisition.
http://purl.obolibrary.org/obo/PATO_0070060	quality of interaction of a substance with electromagnetic radiation	http://purl.obolibrary.org/obo/PATO_0002198	quality of a substance		A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength.
http://purl.obolibrary.org/obo/CL_4023059	committed oligodendrocyte precursor	http://purl.obolibrary.org/obo/CL_0000123	neuron associated cell (sensu Vertebrata)		An oligodendrocyte precursor cell that is committed to differentiate.
http://purl.obolibrary.org/obo/UBERON_8600006	visceral striated muscle tissue	http://purl.obolibrary.org/obo/UBERON_8600004	visceral muscle tissue		A striated muscle tissue that is associated with soft internal organs (viscera).
http://purl.obolibrary.org/obo/CL_4033015	retinal astrocyte	http://purl.obolibrary.org/obo/CL_0009004	retinal cell		A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons.
http://purl.obolibrary.org/obo/CL_4040002	enteroglial cell	http://purl.obolibrary.org/obo/CL_0000125	glial cell		Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP).
http://purl.obolibrary.org/obo/UBERON_8450004	intercostal element	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		An anatomical structure located within an intercostal space.
http://purl.obolibrary.org/obo/HP_6001157	Occupational exposure to frequent kneeling	http://purl.obolibrary.org/obo/HP_0035010	Occupational exposure history		A history of exposure to frequent squatting/kneeling and/or heavy lifting.
http://purl.obolibrary.org/obo/HP_6001158	Trochanteric pain	http://purl.obolibrary.org/obo/HP_0030838	Hip pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the structures around the greater trochanter (the bony prominence on the outer part of the femur).
http://purl.obolibrary.org/obo/HP_6001159	Pulsatile mass in extremity	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		A noticeable lump or swelling in the arm or leg that you can feel with you fingers and this lump is beating or pulsating, similar to the feeling of a heartbeat.
http://purl.obolibrary.org/obo/HP_6001160	Abnormal R wave	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		Any anomaly of the R wave of the EKG, which is the first upward deflection after the P wave. The R wave reflects early ventricular depolarisation.
http://purl.obolibrary.org/obo/HP_6001161	Poor R-wave progression	http://purl.obolibrary.org/obo/HP_6001160	Abnormal R wave		Absence of the normal increase in size of the R wave in the precordial leads when advancing from lead V1 to V6 of the electrocardiogram.
http://purl.obolibrary.org/obo/HP_6001162	Prominent V1-V2 R wave	http://purl.obolibrary.org/obo/HP_6001160	Abnormal R wave		The R wave in leads V1-V2 is normally considerably smaller in amplitude than the S wave in the same leads. Prominent R wave in these leads implies the R wave is larger than the S-wave, which may indicate cardiovascular pathology. This term includes Tall R wave in lead V1, which is defined by a R/S ratio greater than 1.
http://purl.obolibrary.org/obo/HP_6001163	Finger mass	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		An abnormal enlargement or swelling localized to a finger.
http://purl.obolibrary.org/obo/HP_6001164	Foot mass	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		An abnormal enlargement or swelling localized to a foot.
http://purl.obolibrary.org/obo/HP_6001410	Elevated circulating succinylacetone concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		The concentration of succinylacetone in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_5210430	Hindfoot deformity	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		A structural deformity of the hindfoot, the posterior region of the foot formed by the talus and calcaneus.
http://purl.obolibrary.org/obo/HP_5210419	Autoimmune cytopenia	http://purl.obolibrary.org/obo/HP_0002960	Autoimmunity		A reduction in one or more peripheral blood cell lineages resulting from immune-mediated destruction or impairment caused by an autoimmune process.
http://purl.obolibrary.org/obo/HP_5210411	Decreased total T cell number	http://purl.obolibrary.org/obo/HP_0011839	Abnormal total T cell number		Abnormal decrease of absolute number (either count per volume or proportion of total lymphocytes) of T cells or of a subset of T cells, commonly characterized as CD3+ lymphocytes, in the blood, compared to a reference range for a given sex and age-group. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_5210425	Decreased total CD8+ T cell number	http://purl.obolibrary.org/obo/HP_0031393	Abnormal total CD8+ T cell number		Abnormal decrease of the absolute number of cytotoxic CD3+CD8+ T cells (measured the absolute count per volume or as percentage of total CD3+ T cells in the blood), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210409	Abnormal effector memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410379	Abnormal memory CD4+ T cell proportion		An abnormal proportion of effector memory CD4-positive memory T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells may have a CD3/CD4/CD62L-/CD45RA phenotype.
http://purl.obolibrary.org/obo/HP_5210424	Increased total CD8+ T cell number	http://purl.obolibrary.org/obo/HP_0031393	Abnormal total CD8+ T cell number		Abnormal increase of the absolute number of cytotoxic CD3+CD8+ T cells (measured the absolute count per volume or as percentage of total CD3+ T cells in the blood), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210415	Decreased total CD4+ T cell number	http://purl.obolibrary.org/obo/HP_0025183	Abnormal total CD4+ T cell number		Abnormal decrease of absolute number of helper CD3+CD4+ T cells (either count per volume or percentage of total lymphocytes), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210416	Increased CD4+ T cell number	http://purl.obolibrary.org/obo/HP_0025183	Abnormal total CD4+ T cell number		Abnormal increase of absolute number of helper CD3+CD4+ T cells (either count per volume or percentage of total lymphocytes), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210412	Increased total T cell number	http://purl.obolibrary.org/obo/HP_0011839	Abnormal total T cell number		Abnormal increase of absolute number (either count per volume or proportion of total lymphocytes) of T cells or of a subset of T cells, commonly characterized as CD3+ lymphocytes, in the blood, compared to a reference range for a given sex and age-group. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_5210410	Abnormal central memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410379	Abnormal memory CD4+ T cell proportion		An abnormal proportion of central memory CD4-positive memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_5210377	Increased CD4+ TEMRA T cell proportion	http://purl.obolibrary.org/obo/HP_0410379	Abnormal memory CD4+ T cell proportion		An abnormally increased proportion of CD4-positive TEMRA T cells (terminally differentiated effector memory T cells re-expressing CD45RA), relative to total CD4-positive T cells in the blood. These cells have a CD45RA-positive, CD45RO-negative, CCR7-negative phenotype.
http://purl.obolibrary.org/obo/HP_5210413	Decreased total T cell proportion	http://purl.obolibrary.org/obo/HP_5210411	Decreased total T cell number		Abnormal decrease in the proportion of T cells, commonly characterized as CD3+ lymphocytes, measured as a percentage of total lymphocytes in the blood, compared to a reference range for a given sex and age-group. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_5210414	Increased total T cell proportion	http://purl.obolibrary.org/obo/HP_5210412	Increased total T cell number		Abnormal increase in the proportion of T cells, commonly characterized as CD3+ lymphocytes, measured as a percentage of total lymphocytes in the blood, compared to a reference range for a given sex and age-group. These may include both TCR alpha/beta and gamma/delta T cells.
http://purl.obolibrary.org/obo/HP_5210417	Increased total CD4+ T cell count	http://purl.obolibrary.org/obo/HP_5210416	Increased CD4+ T cell number		Abnormal increase of absolute count of helper CD3+CD4+ T cells (quantified as count per volume), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210418	Decreased total CD4+ T cell count	http://purl.obolibrary.org/obo/HP_5210415	Decreased total CD4+ T cell number		Abnormal decrease of absolute count of helper CD3+CD4+ T cells (quantified as count per volume), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210420	Severe eczema	http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis		A severe form of eczema characterised by extensive skin involvement and/or persistent or recurrent symptoms requiring intensive treatment.
http://purl.obolibrary.org/obo/HP_5210421	Autoimmune hepatitis	http://purl.obolibrary.org/obo/HP_0012115	Hepatitis		A chronic inflammatory liver disease characterised by immune-mediated hepatocellular injury resulting from an autoimmune process.
http://purl.obolibrary.org/obo/HP_5210422	Non-infectious encephalitis	http://purl.obolibrary.org/obo/HP_0033429	Neuroinflammation		A disorder of the brain not caused by an infectious agent, characterised by inflammation of the brain parenchyma. It may present with an altered level of consciousness, focal or multifocal neurologic deficits, and seizures; unlike infectious encephalitis, fever is often absent, and autoimmune forms frequently present subacutely with cognitive, psychiatric, or behavioural changes.
http://purl.obolibrary.org/obo/HP_5210423	Autoimmune encephalitis	http://purl.obolibrary.org/obo/HP_5210422	Non-infectious encephalitis		An inflammation of the brain parenchyma caused by an autoimmune process directed against neuronal or glial antigens.
http://purl.obolibrary.org/obo/HP_5210426	Decreased total CD8+ T cell count	http://purl.obolibrary.org/obo/HP_5210425	Decreased total CD8+ T cell number		Abnormal decrease of cytotoxic CD3+CD8+ T cells, measured as the total count per volumne in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210427	Increased total CD8+ T cell count	http://purl.obolibrary.org/obo/HP_5210424	Increased total CD8+ T cell number		Abnormal increase of cytotoxic CD3+CD8+ T cells, measured as the total count per volumne in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_5210428	HSV pneumonia	http://purl.obolibrary.org/obo/HP_5210240	Unusual HSV infection		Infection of the lung parenchyma with herpes simplex virus, resulting in inflammation of the lung parenchyma with impaired respiratory function.
http://purl.obolibrary.org/obo/HP_5210429	Recurrent Haemophilus influenzae conjunctivitis	http://purl.obolibrary.org/obo/HP_5210260	Recurrent conjunctivitis		Recurrent episodes of conjunctivitis caused by infection with Haemophilus influenzae, characterised by inflammation of the conjunctiva associated with conjunctival injection and purulent ocular discharge.
http://purl.obolibrary.org/obo/HP_6001480	Erythematous scalp plaque	http://purl.obolibrary.org/obo/HP_0025474	Erythematous plaque		A circumscribed, palpable, potentially elevated, erythematous lesion > 1 cm in diameter and localized to the scalp. Erythematous plaques exhibiting erythema, i.e., abnormal redness of the skin due to localized dilation and congestion of superficial dermal capillaries, typically as a result of inflammation, irritation, infection, or vasodilation, and usually blanching with pressure.
http://purl.obolibrary.org/obo/HP_6001481	Positive hair pull test	http://purl.obolibrary.org/obo/HP_0100037	Abnormality of the scalp hair		An abnormal result of the hair pull test, in which the clinician selects 50 to 60 hairs and holds the bundle close to the scalp between the thumb, index finger, and long finger. The clinician then firmly pulls on the bundle using slow traction as the fingers slide down the hair shaft, avoiding a fast and forceful tug. The hair pulls are performed at the vertex, parietal areas, and the occipital area of the scalp. Next, the pulled hairs are counted. Any broken hairs that were extracted from the bundle during the pull are discarded. If more than 10 percent of the hairs in each bundle are removed from a scalp area, the hair pull test is considered positive.
http://purl.obolibrary.org/obo/HP_6001482	Loss of acquired purposeful hand skills	http://purl.obolibrary.org/obo/HP_0033044	Motor regression		A type of neurodevelopmental regression characterized by deterioration or disappearance of previously acquired voluntary, goal-directed hand movements, such as reaching, grasping, manipulating objects, or self-feeding.
http://purl.obolibrary.org/obo/HP_6001483	Loss of acquired spoken language	http://purl.obolibrary.org/obo/HP_0034332	Cognitive regression		A type of neurodevelopmental regression characterized by deterioration or disappearance of previously acquired expressive verbal communication, including words, phrases, or sentences the individual had used meaningfully, after these skills had been acquired during development.
http://purl.obolibrary.org/obo/HP_6001484	Postnatal deceleration of headgrowth	http://purl.obolibrary.org/obo/HP_0000240	Abnormality of skull size		Slowing of the rate of head circumference growth occurring after birth, in an individual with normal head circumference at birth, leading to progressive deviation from normal growth curves and, in many cases, acquired (postnatal, secondary) microcephaly.
http://purl.obolibrary.org/obo/HP_6001485	Foot small muscle atrophy	http://purl.obolibrary.org/obo/HP_0008944	Distal lower limb amyotrophy		Wasting of the small muscles of the foot such as the abductor hallucis, flexor digitorum brevis, and the interossei muscles.
http://purl.obolibrary.org/obo/UBERON_0018143	transverse process of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0001077	transverse process of vertebra		A transverse process that is part of a cervical vertebra.
http://purl.obolibrary.org/obo/UBERON_0003071	eye primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles.
http://purl.obolibrary.org/obo/HP_3000079	Abnormal mandibular symphysis morphology	http://purl.obolibrary.org/obo/HP_0031816	Abnormal oral morphology		A structural abnormality of a mandibular symphysis.
http://purl.obolibrary.org/obo/HP_3000002	Abnormal inner ear epithelium morphology	http://purl.obolibrary.org/obo/HP_0011390	Abnormal inner ear morphology		Any structural anomaly of an inner ear epithelium.
http://purl.obolibrary.org/obo/GO_0099177	regulation of trans-synaptic signaling	http://purl.obolibrary.org/obo/GO_0023051	regulation of signaling		Any process that modulates the frequency, rate or extent of trans-synaptic signaling.
http://purl.obolibrary.org/obo/HP_0025558	Lamellar cataract with riders	http://purl.obolibrary.org/obo/HP_0007971	Lamellar cataract		Lamellar cataracts with associated linear lens opacities radially extending towards the periphery of the lens.
http://purl.obolibrary.org/obo/GO_0140253	cell-cell fusion	http://purl.obolibrary.org/obo/GO_0009987	cellular process		A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.
http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology	http://purl.obolibrary.org/obo/HP_0000069	Abnormality of the ureter		A structural abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder.
http://purl.obolibrary.org/obo/HP_0025634	Abnormal ureter physiology	http://purl.obolibrary.org/obo/HP_0000069	Abnormality of the ureter		A functional abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder.
http://purl.obolibrary.org/obo/HP_0032499	Giant neutrophil granules	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		The presence of abnormally large granules in neutrophils. This finding can be appreciated on a peripheral blood smear. The finding is characteristic of Chediak Higashi syndrome. The giant granules are derived from azurophil granules, whereas peroxidase-negative granules are not involved in their formation.
http://purl.obolibrary.org/obo/HP_0032500	Exacerbated by tobacco use	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is worsened by smoking tobacco products.
http://purl.obolibrary.org/obo/HP_0032501	Exacerbated by contraceptive medication exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by taking contraceptive medication.
http://purl.obolibrary.org/obo/HP_0032502	Exacerbated by barbiturate exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by taking barbituates.
http://purl.obolibrary.org/obo/HP_0032503	Ameliorated by ethanol ingestion	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by drinking alcohol (ethanol).
http://purl.obolibrary.org/obo/HP_0032504	Lhermitte's sign	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An electric shock-like sensation that occurs on flexion of the neck. This sensation radiates down the spine, often into the legs, arms, and sometimes to the trunk.
http://purl.obolibrary.org/obo/HP_0032505	Hydrophobia	http://purl.obolibrary.org/obo/HP_0002015	Dysphagia		The word hydrophobia has been used to describe the avoidance of drinking in the presence of hydrophobic spasms that can be observed in human rabies (described as a blockage in the throat with worsening of dyspnea). However, rarely, the same word has been used to describe panic reactions observed in a patient when offered a glass of water. This term does not refer to the latter meaning.
http://purl.obolibrary.org/obo/HP_0032506	Alien limb phenomenon	http://purl.obolibrary.org/obo/HP_0004305	Involuntary movements		Alien limb phenomenon refers to involuntary motor activity of a limb in conjunction with the feeling of estrangement from that limb.
http://purl.obolibrary.org/obo/HP_0032507	Labiomental fasciculations	http://purl.obolibrary.org/obo/HP_0007089	Facial-lingual fasciculations		Fasciculations affecting the tongue muscle and the musculature of the chin.
http://purl.obolibrary.org/obo/HP_0032508	Polyembolokoilamania	http://purl.obolibrary.org/obo/HP_5200065	Tactile sensory seeking		Habitual insertion of foreign bodies into bodily orifices.
http://purl.obolibrary.org/obo/HP_0032509	Onychotillomania	http://purl.obolibrary.org/obo/HP_5200065	Tactile sensory seeking		Onychotillomania is characterized by the compulsive or irresistible urge in patients to pick at, pull off, or harmfully bite or chew their nails.
http://purl.obolibrary.org/obo/HP_0032510	Tendon pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to a tendon.
http://purl.obolibrary.org/obo/HP_0032511	Superiorly positioned umbilicus	http://purl.obolibrary.org/obo/HP_0001551	Abnormal umbilicus morphology		The position of the umbilicus (belly button) is abnormally high (superior).
http://purl.obolibrary.org/obo/HP_0032513	Four-vessel umbilical cord	http://purl.obolibrary.org/obo/HP_0011403	Abnormal umbilical cord blood vessel morphology		Four-vessel umbilical cord containing two arteries and two veins.
http://purl.obolibrary.org/obo/HP_0032514	Supernumerary lacrimal punctum	http://purl.obolibrary.org/obo/HP_0011479	Abnormal lacrimal punctum morphology		A congenital developmental anomaly characterized by the presence of an additional lacrimal punctum in an eyelid.
http://purl.obolibrary.org/obo/HP_0032515	Deep dermatophytosis	http://purl.obolibrary.org/obo/HP_0032516	Severe dermatophyte infection		A type of invasive dermatophyte infection of the deep dermis characterized by extensive dermal infiltration by fungal elements.
http://purl.obolibrary.org/obo/HP_0032516	Severe dermatophyte infection	http://purl.obolibrary.org/obo/HP_5210375	Unusual dermatophyte infection		Infection that extends deeply into the dermis by dermatophytes, fungi that typically cause different types of superficial infection (tinea) or skin, hair, or nails.
http://purl.obolibrary.org/obo/HP_0032517	Majocchi's granuloma	http://purl.obolibrary.org/obo/HP_0032516	Severe dermatophyte infection		Majocchi's granuloma (MG) is an inflammatory and granulomatous, dermatophytic infection characterized by a granulomatous inflammation around the hair follicle. Histopathologically, MG demonstrates a nodular perifollicular granulomatous infiltrate of lymphoid cells, macrophages, epithelioid cells, multinucleated giant cells, and neutrophils. Unlike superficial dermatophytoses, fungal hyphae and spores can be detected not only on the surface of the epidermis but also within or around the hair follicles.
http://purl.obolibrary.org/obo/HP_0032518	Disseminated dermatophytosis	http://purl.obolibrary.org/obo/HP_0032516	Severe dermatophyte infection		A type of invasive dermatophyte infection characterized by vascular involvement and dissemination to other organs.
http://purl.obolibrary.org/obo/HP_0032519	Increased Burr cell count	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Burr cells, also known as echinocytes, have a speculated border over the entire cell surface. Burr cells are commonly found in both end-stage renal disease and liver disease. Small numbers of Burr cells are commonly found in healthy individuals.
http://purl.obolibrary.org/obo/HP_0032520	Masseter muscular weakness	http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology		Reduced strength of the masseter muscle, whose primary function is to elevate the mandible and thereby raise the mandible towards the maxilla, closing the jaw.
http://purl.obolibrary.org/obo/HP_0032521	Self hugging	http://purl.obolibrary.org/obo/HP_5200019	Stereotypic whole-body movements		Involuntary, tic-like movements consisted of crossing both arms across the chest and tensing the body or clasping the hands and squeezing the arms to the sides. The movements last a few seconds and may occur in series or flurries, generally accompanied by facial grimacing and occasional grunting.
http://purl.obolibrary.org/obo/HP_0032522	Ameliorated by immunosuppresion	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with immunosuppresive medication.
http://purl.obolibrary.org/obo/HP_0032523	Tendon thickening	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		An abnormal increase in the thickness (diameter) of a tendon.
http://purl.obolibrary.org/obo/HP_0032524	Long thumb	http://purl.obolibrary.org/obo/HP_0001172	Abnormal thumb morphology		Length of the thumb is greater than normal.
http://purl.obolibrary.org/obo/HP_0032525	Exacerbated by acetylcholinesterase inhibitor exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by treatment with an acetylcholinesterase inhibitor such as tensilon (edrophonium) or pyridostigmine (Mestinon).
http://purl.obolibrary.org/obo/HP_0032526	Ameliorated by acetylcholinesterase inhibitor	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by an acetylcholinesterase inhibitor such as mestinon or tensilon.
http://purl.obolibrary.org/obo/HP_0032527	Inferiorly positioned umbilicus	http://purl.obolibrary.org/obo/HP_0001551	Abnormal umbilicus morphology		The position of the umbilicus (belly button) is abnormally low (inferior).
http://purl.obolibrary.org/obo/HP_0032528	Elevated urinary 4-hydroxybutyric acid	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		An increased amount of 4-hydroxybutyric acid in the urine.
http://purl.obolibrary.org/obo/HP_0032530	Decreased tissue succinic semialdehyde dehydrogenase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Reduced level of succinic semialdehyde dehydrogenase (SSADH).
http://purl.obolibrary.org/obo/HP_0032532	Elevated CSF 4-hydroxybutyric acid concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		Abnormally increased level of 4-hydroxybutyric acid in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0032533	Elevated circulating acetone concentration	http://purl.obolibrary.org/obo/HP_0410175	Hyperketonemia		An increased level of acetone in the blood circulation. Acetone is one of the predominant ketone bodies.
http://purl.obolibrary.org/obo/HP_0032534	Exacerbated by methylxanthine ingestion	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is worsened by ingestion of food containing a methylxanthine compound (for instance, coffee, caffeine, chocolate).
http://purl.obolibrary.org/obo/HP_0032535	Cervical (neck)	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in the neck.
http://purl.obolibrary.org/obo/HP_0032536	Increased number of lymph nodes	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		An abnormally elevated number of lymph nodes in an anatomical region.
http://purl.obolibrary.org/obo/HP_0032537	Delayed fracture healing	http://purl.obolibrary.org/obo/HP_0011843	Abnormal musculoskeletal physiology		A delay in healing of a fracture past the expected duration.
http://purl.obolibrary.org/obo/HP_0032538	Pretibial dimple	http://purl.obolibrary.org/obo/HP_0010781	Skin dimple		A groove or crease on the shins (pretibial, i.e., over the shin bone). Pretibial creases may be obvious at birth and may range from 3 cm to over 15 cm in length and lengthen as the limb grows. They appear as an elongated dimple because of the attachment of skin to underlying tissue (e.g., to the tibia). The dimple or crease grows in proportion to the growth of the leg.
http://purl.obolibrary.org/obo/HP_0032539	Joint extensor surface localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in extensor surface of the joint. The extensor surface refers to the skin on the opposite side of a joint.
http://purl.obolibrary.org/obo/HP_0032540	Joint flexor surface localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in flexor surface of the joint. The flexor surface refers to the skin that touches when a joint is bent (flexed).
http://purl.obolibrary.org/obo/HP_0032541	Knuckle pad	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		Knuckle pads are benign fibrofatty subcutaneous pads located over the proximal interphalangeal (PIP) joints that can be mistaken for arthritis. Rarely they affect the dorsal aspect of the metacarpophalangeal (MCP) joints. Clinically they are painless and often affect both hands in an asymmetrical pattern.
http://purl.obolibrary.org/obo/HP_0032542	Exacerbated by pregnancy	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is worsened by being pregnant.
http://purl.obolibrary.org/obo/HP_0032543	Lithoptysis	http://purl.obolibrary.org/obo/HP_0032016	Abnormal sputum		Expectoration (coughing up) of a broncholith. Broncholithiasis is defined as the presence of calculi in the tracheobronchial tree. It is a rare disease but can be characterized by clinical and radiological findings of a calcified lymph node eroding bronchial wall and opening into the bronchial lumen.
http://purl.obolibrary.org/obo/HP_0410397	Bronchiolectasis	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Saccular dilatation of the terminal bronchioles.
http://purl.obolibrary.org/obo/HP_0410399	Positive blood lead test	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Detection of lead in the blood.
http://purl.obolibrary.org/obo/HP_0410400	Absent sebaceous glands	http://purl.obolibrary.org/obo/HP_0032226	Abnormal sebaceous gland morphology		Absence of the sebaceous gland, the holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.
http://purl.obolibrary.org/obo/HP_0410401	Worse in evening	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		Applies to a sign or symptom that is exacerbated in the evening as compared to the day.
http://purl.obolibrary.org/obo/HP_0500258	Abnormal carbon dioxide level in cord blood	http://purl.obolibrary.org/obo/HP_0410211	Abnormal blood gas level in cord blood		Abnormal amount of carbon dioxide in umbilical cord blood
http://purl.obolibrary.org/obo/HP_0500259	Abnormal oxygen level in cord blood	http://purl.obolibrary.org/obo/HP_0410211	Abnormal blood gas level in cord blood		An abnormal level of blood oxygen in the cord blood.
http://purl.obolibrary.org/obo/HP_0500260	Triggered by head trauma	http://purl.obolibrary.org/obo/HP_0031135	Triggered by physical trauma		Applies to a sign or symptom that is provoked or brought about by exposure to a head trauma.
http://purl.obolibrary.org/obo/HP_0500261	Triggered by anesthetics	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to anesthetics.
http://purl.obolibrary.org/obo/PATO_0055004	decreased rate of occurrence	http://purl.obolibrary.org/obo/PATO_0050000	rate of occurence		A rate of occurrence that is relatively low.
http://purl.obolibrary.org/obo/CHEBI_173084	ferroptosis inhibitor	http://purl.obolibrary.org/obo/CHEBI_52206	biochemical role		Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
http://purl.obolibrary.org/obo/CL_0009039	colon goblet cell	http://purl.obolibrary.org/obo/CL_1000320	large intestine goblet cell		A goblet cell that is located in the colon.
http://purl.obolibrary.org/obo/CL_0009046	T cell of medullary sinus of lymph node	http://purl.obolibrary.org/obo/CL_0000084	T cell		A T cell found in the lymph node medullary sinus.
http://purl.obolibrary.org/obo/CL_0009047	macrophage of medullary sinus of lymph node	http://purl.obolibrary.org/obo/CL_0000235	macrophage		A macrophage found in the medullary sinus of the lymph node.
http://purl.obolibrary.org/obo/CL_0009048	anorectum macrophage	http://purl.obolibrary.org/obo/CL_0000235	macrophage		A macrophage that is located in the anorectum.
http://purl.obolibrary.org/obo/CL_0009050	B cell of anorectum	http://purl.obolibrary.org/obo/CL_0000236	B cell		A B cell that is located in the anorectum.
http://purl.obolibrary.org/obo/CL_0009051	T cell of anorectum	http://purl.obolibrary.org/obo/CL_0000084	T cell		A T cell that is located in the anorectum.
http://purl.obolibrary.org/obo/CL_0009053	stromal cell of anorectum lamina propria	http://purl.obolibrary.org/obo/CL_0009021	stromal cell of lamina propria of large intestine		A stromal cell found in the lamina propria of the anorectum.
http://purl.obolibrary.org/obo/CL_0009056	transit amplifying cell of anorectum	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		A transit amplifying cell that is located in the anorectum.
http://purl.obolibrary.org/obo/CL_0009066	stratified squamous epithelial cell of anal canal	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		A stratified squamous epithelial cell that is part of the anal canal.
http://purl.obolibrary.org/obo/CHEBI_191201	branched-chain keto acid anion	http://purl.obolibrary.org/obo/CHEBI_35903	oxo carboxylic acid anion		An oxo carboxylic acid anion that is the conjugate base of branched-chain keto acid resulting from the deprotonation of the carboxy group.
http://purl.obolibrary.org/obo/HP_0034318	Unusual virus reactivation	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Reactivation is the mechanism whereby a latent virus that has infected a host cell switches to a lytic stage, undergoing productive viral replication and allowing the virus to spread. This term refers to reactivation regarded as unusual because of frequency, intensity, location, or nature of the virus, in the sense that the reactivation would not be observed in an immunocompetent host.
http://purl.obolibrary.org/obo/HP_0034391	Elbow contracture	http://purl.obolibrary.org/obo/HP_0100360	Upper-limb joint contracture		A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin.
http://purl.obolibrary.org/obo/HP_0020222	Hypohomocysteinemia	http://purl.obolibrary.org/obo/HP_0010919	Abnormal circulating homocysteine concentration		A decreased concentration of homocysteine in the blood.
http://purl.obolibrary.org/obo/HP_0020223	Dermal sinus tract	http://purl.obolibrary.org/obo/HP_0034238	Closed neural tube defect		A dermal sinus tract is an abnormality present at birth over the dorsal midline where an abnormal epithelialized connection from the skin tracks inwards towards the spine, most commonly seen in the lumbosacral region.
http://purl.obolibrary.org/obo/HP_0034288	Elevated circulating reverse T3 concentration	http://purl.obolibrary.org/obo/HP_0025120	Abnormal circulating reverse T3 concentration		Concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034289	Elevated circulating rT3/T3 ratio	http://purl.obolibrary.org/obo/HP_0031508	Abnormal circulating thyroid hormone concentration		An abnormally increased ratio of the concentrations of reverse T3 to T3 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034290	Elevated circulating tiglylglycine concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		Concentration of tiglylglycine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034291	Elevated circulating creatine concentration	http://purl.obolibrary.org/obo/HP_0012113	Abnormal circulating creatine concentration		An elevation above the normal range of creatine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034292	Reduced circulating creatine concentration	http://purl.obolibrary.org/obo/HP_0012113	Abnormal circulating creatine concentration		An reduction below the normal range of creatine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034293	Temporal lobe calcification	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		The presence of calcium deposition within the temporal lobe of the brain.
http://purl.obolibrary.org/obo/HP_0034294	Ductal bile plugs	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Bile thrombi that form an obstruction (plug) in a dilated bile duct.
http://purl.obolibrary.org/obo/HP_0034295	Reduced cerebral white matter volume	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		An abnormally low volume of the white matter of the brain.
http://purl.obolibrary.org/obo/HP_0034296	Elevated urine 3,5,6-trichloro-2-pyridinol level	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of 3,5,6-trichloro-2-pyridinol in the urine.
http://purl.obolibrary.org/obo/HP_0034297	Elevated circulating tetracosanoic acid concentration	http://purl.obolibrary.org/obo/HP_0010966	Abnormal circulating fatty acid anion concentration		The concentration of tetracosanoic acid (a C24 straight-chain saturated fatty acid) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034298	Elevated circulating hexacosanoic acid concentration	http://purl.obolibrary.org/obo/HP_0033643	Increased circulating very long-chain fatty acid concentration		The concentration of hexacosanoic acid (a C26 straight-chain saturated fatty acid) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034299	Sertoli cell-only phenotype	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		A histological phenotype observed on testicular biopsy in which only Sertoli cells line the seminiferous tubules of the testis.
http://purl.obolibrary.org/obo/HP_0034300	Decreased acid sphingomyelinase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced activity of the enzyme acid sphingomyelinase activity in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034301	Congenital pouch colon	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		A malformation of the colon in which a pouch-like dilatation of a varying degree of shortened colon is associated with an anorectal malformation. The pouch usually terminates in a fistulous communication with the genitourinary tract.
http://purl.obolibrary.org/obo/HP_0034302	Megalopapilla	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		A congenitally anomalous enlarged optic disc (surface area greater than 2.50 square millimeters). It is considered to be a normal variant without physiological defects.
http://purl.obolibrary.org/obo/HP_0034303	Notched T wave	http://purl.obolibrary.org/obo/HP_0005135	Abnormal T-wave		A bifid T-wave with a notch duration between the 2 peaks at least 0.04 sec and an amplitude at least 0.05 mV.
http://purl.obolibrary.org/obo/HP_0034304	Epsilon wave	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		An electric signal of depolarization observed between the end of the QRS complex and the beginning of the T wave.
http://purl.obolibrary.org/obo/HP_0034314	Abnormal left ventricular ejection fraction	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		Any abnormality of the left ventricular ejection fraction (LVEF), which is the fraction of chamber volume ejected in systole (stroke volume) in relation to the volume of the blood in the ventricle at the end of diastole (end-diastolic volume). Stroke volume (SV) is calculated as the difference between end-diastolic volume (EDV) and end-systolic volume (ESV). LVEF is calculated as [SV/EDV] in percent.
http://purl.obolibrary.org/obo/HP_0034338	Imprinted	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Requires that the abnormal allele be paternal or maternal in origin, depending on the disease-gene relationship. Imprinting refers to a normal developmental process in which either the paternal or maternal allele is inactivated, depending on the specific locus, thus leading to expression from only one copy of the gene. Disease typically manifests when a deleterious variant is inherited from a parent whose copy of the gene would normally be expressed, but not when a deleterious variant is inherited from a parent whose copy of the gene would normally be inactivated.
http://purl.obolibrary.org/obo/HP_0034375	Spherophakia	http://purl.obolibrary.org/obo/HP_0011526	Abnormality of lens shape		Spherophakia is a rare congenital condition that presents with weak zonules around a more spherical crystalline lens with an increased anteroposterior thickness of the lens, and highly myopic eye. The lens zonules are developmentally hypoplastic and abnormally weak and due to non-attachment of the posterior zonules to the equatorial zone of the lens, the lens changes its normal shape to spherical.
http://purl.obolibrary.org/obo/HP_0034378	Urethrovesical occlusion	http://purl.obolibrary.org/obo/HP_0000796	Urethral obstruction		Blockage of the flow of urine from the bladder into the urethra.
http://purl.obolibrary.org/obo/CL_4030029	blood lymphocyte	http://purl.obolibrary.org/obo/CL_2000001	peripheral blood mononuclear cell		A lymphocyte located in blood.
http://purl.obolibrary.org/obo/CL_4023057	cerebellar inhibitory GABAergic interneuron	http://purl.obolibrary.org/obo/CL_1001611	cerebellar neuron		A GABAergic interneuron whose soma is located in the cerebellar cortex.
http://purl.obolibrary.org/obo/UBERON_8480025	skin of clavicle region	http://purl.obolibrary.org/obo/UBERON_0000014	zone of skin		A zone of skin that is above the clavicle zone in the pectoral girdle region.
http://purl.obolibrary.org/obo/CL_4033002	neuroendocrine cell of epithelium of crypt of Lieberkuhn	http://purl.obolibrary.org/obo/CL_1001516	intestinal enteroendocrine cell		A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn.
http://purl.obolibrary.org/obo/HP_0034782	Obstipation	http://purl.obolibrary.org/obo/HP_0002019	Constipation		Obstipation is the inability to pass either stool or flatus (gas).
http://purl.obolibrary.org/obo/HP_0034783	Posttussive emesis	http://purl.obolibrary.org/obo/HP_0002013	Vomiting		Vomiting following a coughing spell.
http://purl.obolibrary.org/obo/HP_0034786	Leukocytoclastic vasculitis	http://purl.obolibrary.org/obo/HP_0034785	Vasculitis by histology		A type of vasculitis characterized by the presence of debris of neutrophils within the blood vessel walls.
http://purl.obolibrary.org/obo/HP_0034788	Pericardial friction rub	http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound		A pericardial friction rub is a grating, to-and-fro sound that occurs in phase with the heart sounds.
http://purl.obolibrary.org/obo/HP_0034790	Abnormal muscle succinate dehydrogenase staining	http://purl.obolibrary.org/obo/HP_0034510	Abnormal muscle tissue enzyme activity or level		Any deviation from the normal amount of staining of succinate dehydrogenase in skeletal muscle tissue.
http://purl.obolibrary.org/obo/HP_0034793	Small intestinal hamartoma	http://purl.obolibrary.org/obo/HP_0100833	Neoplasm of the small intestine		A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the small intestine.
http://purl.obolibrary.org/obo/HP_5200102	Reduced social smiling	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		Reduced production of smiles during engagement with an interactive parent, caregiver, or peer.
http://purl.obolibrary.org/obo/HP_5200105	Reduced imaginative play skills	http://purl.obolibrary.org/obo/HP_5200104	Abnormal play		Reduced or lack of pretending in play (does not assign abstract properties to objects, use invisible objects, or use objects in nonliteral ways other than their intended purpose in play).
http://purl.obolibrary.org/obo/HP_5200108	Nonfunctional or atypical use of objects in play	http://purl.obolibrary.org/obo/HP_0031432	Restricted or repetitive behaviors or interests		Use of objects in atypical, unimaginitive ways other than for which they are intended (banging, throwing, shaking, sorting, lining up, spinning).
http://purl.obolibrary.org/obo/HP_5200110	Infrequent social engagement with peers	http://purl.obolibrary.org/obo/HP_5200020	Abnormal interest in others		Lower than typical number of attempts to engage peers in conversation, play, or other interactions.
http://purl.obolibrary.org/obo/HP_5200111	Avoidance of emotional intimacy	http://purl.obolibrary.org/obo/HP_5200120	Abnormal social emotional interactions		An atypically high tendency to avoid interpersonal exchanges characterizing by sharing of personal feelings, expressions of understanding, affirmation, and demonstrations of caring.
http://purl.obolibrary.org/obo/HP_5200113	Failure to offer information to initiate social interaction	http://purl.obolibrary.org/obo/HP_5200027	Infrequent social initiations		An atypically low tendency to offer information as a means to initiate or sustain social interactions or direct another's attention.
http://purl.obolibrary.org/obo/HP_5200118	Difficulty recognizing another's emotions	http://purl.obolibrary.org/obo/HP_5200021	Reduced social insight		A difficulty in recognizing or interpreting the emotional states of other individuals.
http://purl.obolibrary.org/obo/HP_5200120	Abnormal social emotional interactions	http://purl.obolibrary.org/obo/HP_0025732	Abnormal social development		An atypically low production of emotion social communications including those produced by communicative behaviors such as facial expressions, body language, and verbal communication.
http://purl.obolibrary.org/obo/HP_5200121	Objectification of others	http://purl.obolibrary.org/obo/HP_5200120	Abnormal social emotional interactions		A tendency to interact with others as if they are objects with functional purpose rather than engaging in social/emotional interactions.
http://purl.obolibrary.org/obo/HP_5200124	Indifference to social norms	http://purl.obolibrary.org/obo/HP_5200123	Abnormal response to social norms		Failure to follow social norms (shared standards of acceptable behavior) even though one has awareness of these norms and the ability to follow them.
http://purl.obolibrary.org/obo/HP_5200125	Aggression towards others	http://purl.obolibrary.org/obo/HP_0000718	Aggressive behavior		Aggression that is directed towards other individuals, as opposed to oneself.
http://purl.obolibrary.org/obo/HP_5200126	Aggression towards caregivers	http://purl.obolibrary.org/obo/HP_5200125	Aggression towards others		Aggression that is directed towards caregivers.
http://purl.obolibrary.org/obo/HP_5200127	Aggression toward non-caregivers	http://purl.obolibrary.org/obo/HP_5200125	Aggression towards others		Aggression that is directed towards non-caregivers.
http://purl.obolibrary.org/obo/HP_5200129	Abnormal rituals	http://purl.obolibrary.org/obo/HP_5200130	Insistence on sameness		Insistence on rituals which are self-imposed on a person's environment including directing the behavior of those around them.
http://purl.obolibrary.org/obo/HP_5200134	Jumping	http://purl.obolibrary.org/obo/HP_5200019	Stereotypic whole-body movements		An excessive frequency of jumping in place.
http://purl.obolibrary.org/obo/HP_5200135	Delay in the acquisition of cooperative play skills	http://purl.obolibrary.org/obo/HP_0012434	Delayed early-childhood social milestone development		Failure to acquire the ability to play cooperatively, a type of play in whichchildren work together towards a common goal and in which a child displays interest both in the play and in the the other child or children involved in playing. This ability is observed in neurotypical children from the age of 3 to 6 years.
http://purl.obolibrary.org/obo/HP_5200136	Reduced social reciprocity	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		Reduced responses to other people's emotions and/or a lack of modulation of behaviour according to social context.
http://purl.obolibrary.org/obo/HP_0430048	Intracranial calcification	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		Intracranial calcifications refer to calcifications within the brain parenchyma or vasculature. The five major components of the brain comprise the cerebrum, cerebellum, brain stem, pituitary gland, and hypothalamus.
http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration	http://purl.obolibrary.org/obo/HP_0032180	Abnormal circulating metabolite concentration		Any deviation of the concentration of an orrganic compound from the normal range. An organic compound is defined as any compound that contains a carbon atom.
http://purl.obolibrary.org/obo/HP_0020228	Biospecimen phenotypic feature	http://purl.obolibrary.org/obo/HP_0000001	All		A phenotypic abnormality obvserved in a biospecimen such as a biopsy or an extirpated tumor or tissue.
http://purl.obolibrary.org/obo/HP_0020229	Abnormal lymph-node biospecimen	http://purl.obolibrary.org/obo/HP_0020228	Biospecimen phenotypic feature		Any abnormal phenotypic feature observed in a biospecimen derived from a lymph node, generally obtained by lymph node biopsy (removal of lymph node tissue for microscopic examination).
http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture	http://purl.obolibrary.org/obo/HP_0020229	Abnormal lymph-node biospecimen		Any phenotypic abnormality of the architecture of the tissue of a lymph node.
http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding	http://purl.obolibrary.org/obo/HP_0020229	Abnormal lymph-node biospecimen		Any phenotypic abnormality within cells located in a lymph node.
http://purl.obolibrary.org/obo/HP_0020233	Abnormal lymph-node cellular antigen expression	http://purl.obolibrary.org/obo/HP_0020229	Abnormal lymph-node biospecimen		Abnormal expression of an antigen (marker) by cells located in a lymph node.
http://purl.obolibrary.org/obo/HP_0020234	Altered lymph-node tissue architecture	http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture		An alteration that affects multiple components of the architecture of a lymph node.
http://purl.obolibrary.org/obo/HP_0020235	Effaced lymph-node architecture	http://purl.obolibrary.org/obo/HP_0020234	Altered lymph-node tissue architecture		Effacement of architecture typically refers to a cellular infiltrate destroying the normal follicular architecture of a lymph node. This effacement may result in sheets of cells that do not form clear architecture (seen in many lymphomas) or may lead to replacement of the normal architecture by atypical architecture, for example effacement of normal lymph node architecture (including normal follicles and patent lymph node sinuses) by many abnormal follicles in follicular lymphoma.
http://purl.obolibrary.org/obo/HP_0020236	Vaguely nodular lymph-node architecture	http://purl.obolibrary.org/obo/HP_0020234	Altered lymph-node tissue architecture		In contrast to normal lymph node architecture or that of follicular lymphoma, where follicles are typically distinct and readily identifiable on H&E stained biopsy sections, the cells within an atypical lymph node may show what appear to groups of cells forming vague nodules but not forming clear follicles.
http://purl.obolibrary.org/obo/HP_0020237	Lymph-node capsular invasion by lymphocytes	http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture		Migration of substantial numbers of lymphocytes into the capsule of a lymph node.
http://purl.obolibrary.org/obo/HP_0020238	Lymph-node extracapsular extension by lymph-node lymphocytes	http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture		Migration of lymphocytes into the soft tissues surrounding the lymph node.
http://purl.obolibrary.org/obo/HP_0020239	Increased lymph-node epithelioid histiocyte count	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Number of epithelioid histiocytes (histiocytes are tissue-resident macrophages) located within a lymph node above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020240	Scattered lymph node individual epithelioid histiocytes	http://purl.obolibrary.org/obo/HP_0020239	Increased lymph-node epithelioid histiocyte count		Many individual (not clustered) epithelioid histiocytes throughout at least part of a lymph node.
http://purl.obolibrary.org/obo/HP_0020241	Clustered lymph node epithelioid histiocytes	http://purl.obolibrary.org/obo/HP_0020239	Increased lymph-node epithelioid histiocyte count		Formation of clusters (group of cells positioned near each other) of epithelioid histiocytes within a lymph node.
http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture	http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture		Any phenotypic abnormality of the architecture of follicles of a lymph node.
http://purl.obolibrary.org/obo/HP_0020243	Floral-pattern lymph node follicles	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		Atypical lymph node follicles that have mantle zone cells invaginating/infiltrating into the follicle centers, which is said to confer a flower-like appearance.
http://purl.obolibrary.org/obo/HP_0020244	Colonization of follicles by lymphoma cells	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		In contrast to follicular lymphoma, which typically is a lymphoma that forms follicles or potentially completely replaces normal follicles, some lymphomas (most commonly marginal zone lymphoma) can infiltrate normal follicles so both normal lymphocytes and the infiltrating lymphoma cells are present. This is called colonization of follicles by the lymphoma cells.
http://purl.obolibrary.org/obo/HP_0020245	Crowded lymph-node follicles	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		Reduction in the average distance between adjacent lymph node follicles.
http://purl.obolibrary.org/obo/HP_0020246	Lymph-node follicular lysis	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		An abnormal morphology of hyperplastic lymph node follicles characterized by distortion of the follicular architecture by tongues and clusters of dark blue mantle cells impinging on and invading the reactive germinal center (Mostly T cells and mantle-zone B cells).
http://purl.obolibrary.org/obo/HP_0020247	Non-polarized lymph node germinal centers	http://purl.obolibrary.org/obo/HP_0020255	Abnormal lymph-node germinal center morphology		A loss of the typical polarization of the architecture of a lymph node germinal center.
http://purl.obolibrary.org/obo/HP_0020248	Irregularly shaped lymph node germinal centers	http://purl.obolibrary.org/obo/HP_0020255	Abnormal lymph-node germinal center morphology		A deviation from the typically fairly round or oval form of a lymph node germinal center.
http://purl.obolibrary.org/obo/HP_0020249	Abnormal lymph-node marginal or mantle zone morphology	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		An abnormality of the structure of the mantle or marginal zone of a lymph node.
http://purl.obolibrary.org/obo/HP_0020253	Lymph node with expanded mantle zones	http://purl.obolibrary.org/obo/HP_0020251	Abnormal lymph node mantle zone morphology		Enlargement of the typical outer ring of small lymphocytes (mantle zone) surrounding a germinal center of a lymph node.
http://purl.obolibrary.org/obo/HP_0020254	Lymph node with poorly defined germinal center borders	http://purl.obolibrary.org/obo/HP_0020255	Abnormal lymph-node germinal center morphology		Reduced demarcation of the border between germinal centers and mantle zones. This border is typically seen as a crisp line on hematoxylin and eosin (H&E)-stained lymph node sections.
http://purl.obolibrary.org/obo/HP_0020255	Abnormal lymph-node germinal center morphology	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		Any phenotypic abnormality of germinal centers of a lymph node.
http://purl.obolibrary.org/obo/HP_0020257	Mantle zone pattern	http://purl.obolibrary.org/obo/HP_0020251	Abnormal lymph node mantle zone morphology		This refers to an architectural pattern of infiltration where atypical lymphocytes surround germinal centers, often expanding the mantle zones but without effacing architecture.
http://purl.obolibrary.org/obo/HP_0020261	Poorly defined primary lymph-node follicles	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		Lack of the typical easily recognized delineation of primary follicles within lymph nodes.
http://purl.obolibrary.org/obo/HP_0020262	Progressive transformation of germinal centers	http://purl.obolibrary.org/obo/HP_0020255	Abnormal lymph-node germinal center morphology		This is a condition sometimes seen in a subset of germinal centers of reactive lymph nodes where germinal centers become enlarged and infiltrated by benign mantle zone cells and some T cells.
http://purl.obolibrary.org/obo/HP_0020263	Absent germinal center tingible body macrophages	http://purl.obolibrary.org/obo/HP_0020255	Abnormal lymph-node germinal center morphology		Lack of observable tingible body macrophages (TBMs) in germinal centers (GCs) of secondary lymphoid follicles. TBMs represent unique, large phagocytic cells that reside and are a subset of mononuclear phagocytes.
http://purl.obolibrary.org/obo/HP_0020264	Lack of germinal center mitotic figures	http://purl.obolibrary.org/obo/HP_0020255	Abnormal lymph-node germinal center morphology		Absence of extreme paucity of mitotic figures in a lymph node germinal center.
http://purl.obolibrary.org/obo/HP_0020265	Non-polarized mantle zones	http://purl.obolibrary.org/obo/HP_0020251	Abnormal lymph node mantle zone morphology		Lack of the typical polarization of the outer ring of small lymphocytes (mantle zone) surrounding a germinal center of a lymph node.
http://purl.obolibrary.org/obo/HP_0020266	Hyalinized lymph-node vessels	http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture		Hyalinized means to become clear/translucent such as collagen becoming more pale staining (collagen is typically quite eosinophilic, meaning attracted to the pink/red dye eosin); however, with regard to vessels in the lymph node, hyalinization is often used to describe vessel walls that appear markedly thickened or surrounded by eosinophilic material such as collagen, not necessarily translucent appearing.
http://purl.obolibrary.org/obo/HP_0020267	Lymph-node follicular sclerosis	http://purl.obolibrary.org/obo/HP_0020242	Abnormal lymph-node follicle architecture		Collagen deposition, typically with decreased cellularity, within lymph-node follicles.
http://purl.obolibrary.org/obo/HP_0020268	Compressed lymph-node sinuses	http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture		Loss of the typical patency (openness) of lymph node sinuses.
http://purl.obolibrary.org/obo/HP_0020269	Lymph-node proliferation centers	http://purl.obolibrary.org/obo/HP_0020230	Abnormal lymph-node tissue architecture		Proliferation centers are a finding specific to chronic lymphocytic leukemia/small lymphocytic lymphoma where regions (typically relatively small, comparable to the size of a lymph node follicle) appear more pale on H&E stained sections (though they may become enlarged to merge together). These areas contain increased numbers of enlarged lymphoma cells with nucleoli (prolymphocytes and paraimmunoblasts) and show a higher proliferation rate (readily visualized with a Ki-67 immunohistochemical stain) than surrounding lymphoma cells. They can be mistaken as vague follicle formation and are therefore sometimes referred to as pseudofollicles.
http://purl.obolibrary.org/obo/HP_0020270	Cytologic atypia in mantle cells	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Lymphocytes in the mantle zones of lymph node secondary follicles show cellular atypia such as enlarged size, increased cytoplasm, atypical distribution of chromatin, or irregular nuclear contours.
http://purl.obolibrary.org/obo/HP_0020271	Increased lymph-node eosinophils	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Eosinophils count within a lymph node above normal limits.
http://purl.obolibrary.org/obo/HP_0020272	Increased lymph-node plasma cells	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Number of plasma cells per lymph node above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020273	High lymph node non-germinal center mitotic activity	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Increased numbers of mitotic figures outside of germinal centers.
http://purl.obolibrary.org/obo/HP_0020274	Lymph-node lymphocyte monocytoid morphology	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Lymphocytes that show morphologic features resembling monocytes, such as increased cytoplasm and slightly enlarged nuclei that are more irregular than most lymph node lymphocytes.
http://purl.obolibrary.org/obo/HP_0020275	Reduced lymph node lymphocyte morphological variability	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Decreased morphological variability of lymph node lymphocytes as compared to the typically somewhat heterogeneous morphology of populations of benign lymph node lymphocytes.
http://purl.obolibrary.org/obo/HP_0020276	Increased large lymphocytes in lymph node	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		An increased number of large lymphocytes within a lymph node compared to a normal non-reactive lymph node.
http://purl.obolibrary.org/obo/HP_0020277	Hodgkin morphology cells	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Hodgkin cells are typically large and often show very large nucleoli and sometimes binucleation or multinucleation. Reed-Sternberg cells are a type of Hodgkin cell that is binucleated with very large nucleoli that stains slightly red on H&E stained sections (often said to mimic owl eyes). Other Hodgkin cell morphologies include cells that are dying with dark basophilic (blue) nuclei that appear somewhat smudged (mummified cells) and cells with a large space around or adjacent to the nuclei and retracted cytoplasm after tissue fixation (lacunar cells). Hodgkin cells are characteristic of Hodgkin lymphoma, however several non-Hodgkin lymphomas and noN-neoplastic conditions are known to sometimes show a few similar morphology cells.
http://purl.obolibrary.org/obo/HP_0020279	Irregular lymph-node lymphocyte nuclei	http://purl.obolibrary.org/obo/HP_0020278	Abnormal lymph-node lymphoctye nuclear morphology		Lymph node lymphocyte nuclei that are more irregular than the typical round to slightly oval shapes of the majority of lymph node lymphocytes.
http://purl.obolibrary.org/obo/HP_0020280	Lymph-node Dutcher bodies	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Dutcher bodies are collections of immunoglobulin protein that overlie or invaginate into the nucleus of plasma cells. These nuclear pseudoinclusions can occasionally be seen in reactive states and may be increased in specific neoplastic conditions.
http://purl.obolibrary.org/obo/HP_0020281	Finely dispersed lymph node lymphocyte chromatin	http://purl.obolibrary.org/obo/HP_0020282	Abnormal lymph-node lymphocyte chromatin		Nuclei of lymphocytes with less dense, evenly distributed chromatin than the normal densely packed, often clumped chromatin of mature lymphocytes.
http://purl.obolibrary.org/obo/HP_0020282	Abnormal lymph-node lymphocyte chromatin	http://purl.obolibrary.org/obo/HP_0020278	Abnormal lymph-node lymphoctye nuclear morphology		Any phenotypic abnormality of the chromatin (complex of DNA and protein which comprises chromosomes) of lymphocytes that are located within a lymph node.
http://purl.obolibrary.org/obo/HP_0020283	Clumping of lymph node lymphocyte chromatin	http://purl.obolibrary.org/obo/HP_0020282	Abnormal lymph-node lymphocyte chromatin		Nuclei of lymphocytes show multiple small densely packed areas of chromatin that appear as relatively evenly spaced clumps of basophilic (blue) staining within the nuclei on Hematoxylin and eosin (H&E) stained sections.
http://purl.obolibrary.org/obo/HP_0020284	Abnormal lymph-node lymphocyte cytoplasm morphology	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		Any phenotypic abnormality of the cytoplasm (material located within the cell membrane but excluding the nucleus) of lymphocytes that are located within a lymph node.
http://purl.obolibrary.org/obo/HP_0020285	Decreased lymph node lymphocyte cytoplasm	http://purl.obolibrary.org/obo/HP_0020284	Abnormal lymph-node lymphocyte cytoplasm morphology		The amount of cytoplasm in lymphocytes is even less than the relatively little cytoplasm found in the majority of lymphocytes within lymph nodes.
http://purl.obolibrary.org/obo/HP_0020286	Increased lymph node lymphocyte cytoplasm	http://purl.obolibrary.org/obo/HP_0020284	Abnormal lymph-node lymphocyte cytoplasm morphology		Increased amount of cytoplasm compared to the majority of lymphocytes in a benign lymph node.
http://purl.obolibrary.org/obo/HP_0020287	Abnormal level of lymph-node cellular CD19 expression	http://purl.obolibrary.org/obo/HP_0020288	Abnormal lymph-node cellular B-cell marker expression		Detection of an abnormal level of CD19 on the cell(s) of interest in a lymph node with the use of anti-CD19 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0020288	Abnormal lymph-node cellular B-cell marker expression	http://purl.obolibrary.org/obo/HP_0020233	Abnormal lymph-node cellular antigen expression		Abnormal expression of an antigen (marker) that is normally expressed by B lymphocytes.
http://purl.obolibrary.org/obo/HP_0020289	Abnormal level of lymph-node cellular CD20 expression	http://purl.obolibrary.org/obo/HP_0020288	Abnormal lymph-node cellular B-cell marker expression		Detection of abnormal levels of CD20 on the cell(s) of interest with the use of anti-CD20 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0020290	CD79a expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD79a on the cell(s) of interest with the use of anti-CD79a antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0020291	Increased lymph-node cellular CD20 expression	http://purl.obolibrary.org/obo/HP_0020289	Abnormal level of lymph-node cellular CD20 expression		Increased levels of CD20 expression compared to normal B cells.
http://purl.obolibrary.org/obo/HP_0020292	Decreased lymph-node cellular CD20 expression	http://purl.obolibrary.org/obo/HP_0020289	Abnormal level of lymph-node cellular CD20 expression		Decreased levels of CD20 expression compared to normal B cells.
http://purl.obolibrary.org/obo/HP_0020293	Decreased lymph-node cellular CD19 expression	http://purl.obolibrary.org/obo/HP_0020287	Abnormal level of lymph-node cellular CD19 expression		Decreased levels of CD19 expression compared to normal B cells.
http://purl.obolibrary.org/obo/HP_0020294	Increased lymph-node cellular CD19 expression	http://purl.obolibrary.org/obo/HP_0020287	Abnormal level of lymph-node cellular CD19 expression		Increased levels of CD19 expression compared to normal B cells.
http://purl.obolibrary.org/obo/HP_0020295	PAX5 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of PAX5 on the cell(s) of interest with the use of anti-PAX5 antibodies conjugated to a chromogen (for immunohistochemistry).
http://purl.obolibrary.org/obo/HP_0020296	Germinal center B-lymphocyte BCL2 expression	http://purl.obolibrary.org/obo/HP_0020233	Abnormal lymph-node cellular antigen expression		Positive staining for BCL2 apoptosis regulator protein in lymph-node germinal center B cells.
http://purl.obolibrary.org/obo/HP_0430050	Anti-thyroid antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against one or more components on the thyroid.
http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430150	Positive blood infectious agent test		Positive serology for a exposure to an infectious agent (i.e., examining serum for the presence of pathogen-specific antibodies).
http://purl.obolibrary.org/obo/HP_0430052	Anti-SARS-CoV-2 coronavirus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2).
http://purl.obolibrary.org/obo/HP_0430053	Anti-West Nile virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of the West Nile virus.
http://purl.obolibrary.org/obo/HP_0430054	Anti-microfilaria antibody positivity	http://purl.obolibrary.org/obo/HP_0430060	Bloodstream parasite-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of a microfilaria (parasite).
http://purl.obolibrary.org/obo/HP_0430055	Anti-trypanosoma cruzi antibody positivity	http://purl.obolibrary.org/obo/HP_0430060	Bloodstream parasite-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of trypanosoma cruzi.
http://purl.obolibrary.org/obo/HP_0430056	Anti-chikungunya virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of chikungunya virus.
http://purl.obolibrary.org/obo/HP_0430057	Anti-chlamydia psittaci antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against a component of chlamydia psittaci.
http://purl.obolibrary.org/obo/HP_0430058	Anti-herpes simplex antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of herpes simplex.
http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		The presence of antibodies in the blood circulation that react against a virus.
http://purl.obolibrary.org/obo/HP_0430060	Bloodstream parasite-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		The presence of antibodies in the blood circulation that react against a parasite.
http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		The presence of antibodies in the blood circulation that react against a bacterium.
http://purl.obolibrary.org/obo/HP_0430062	Anti-Japanese encephalitis virus-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of the Japanese encephalitis virus.
http://purl.obolibrary.org/obo/HP_0430063	Anti-chlamydia trachomatis-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against a component of chlamydia trachomatis.
http://purl.obolibrary.org/obo/HP_0430064	Anti-Epstein-Barr virus-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of the Epstein Barr virus (EBV).
http://purl.obolibrary.org/obo/HP_0430065	Anti-babesia-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430060	Bloodstream parasite-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of a parasite of the genus Babesia (parasite).
http://purl.obolibrary.org/obo/HP_0430066	Anti-Zikavirus-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of the Zika virus.
http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test	http://purl.obolibrary.org/obo/HP_0430150	Positive blood infectious agent test		Positive (abnormal) result of a test such as polymerase chain reaction that is targeted against a nucleic acid sequence specific for a pathogen.
http://purl.obolibrary.org/obo/HP_0430068	Positive microfilaria PCR test in the blood circulation	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of a microfilarial parasite in the blood circulation.
http://purl.obolibrary.org/obo/HP_0430069	Positive JC-virus PCR test in the blood circulation	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of the JC-virus (JC-Polyomavirus, John Cunningham virus) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0430070	Placenta previa	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Implantation of the placenta over or near the internal os of the cervix.
http://purl.obolibrary.org/obo/HP_0430072	Abnormal circulating beta-carotene concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		Any deviation of the concentration of beta-carotene in the blood circulation from the normal range.
http://purl.obolibrary.org/obo/HP_0430073	Decreased circulating beta-carotene concentration	http://purl.obolibrary.org/obo/HP_0430072	Abnormal circulating beta-carotene concentration		The concentration of beta-carotene in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0430074	Increased circulating beta-carotene concentration	http://purl.obolibrary.org/obo/HP_0430072	Abnormal circulating beta-carotene concentration		The concentration of beta-carotene in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0430075	Mammary blocked duct	http://purl.obolibrary.org/obo/HP_0031094	Abnormal breast physiology		Blocked mammary ducts represent an area of localized milk stasis, typically associated with breast engorgement and resulting in a localized tender breast lump or area of blushed color; the breast may feel hot; and there may be a white, painful bleb on the end of the nipple.
http://purl.obolibrary.org/obo/HP_0430076	Bloodstream antifungal antibody positivity	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		The presence of antibodies in the blood circulation that react against a fungus.
http://purl.obolibrary.org/obo/HP_0430077	Anti-coccidioidal antibody positivity	http://purl.obolibrary.org/obo/HP_0430076	Bloodstream antifungal antibody positivity		The presence of antibodies in the blood circulation that react against a component of a fungus of the Coccidioides genus.
http://purl.obolibrary.org/obo/HP_0430078	Anti-cryptococcal antibody positivity	http://purl.obolibrary.org/obo/HP_0430076	Bloodstream antifungal antibody positivity		The presence of antibodies in the blood circulation that react against a component of a fungus of the Cryptoccous genus.
http://purl.obolibrary.org/obo/HP_0430079	Anti-mycoplasma antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against a mycoplasmal component.
http://purl.obolibrary.org/obo/HP_0430080	Anti-rickettsial antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against a component of a rickettsial bacterium. Rickettsiae are gram-negative bacteria with an obligate intracellular life cycle circulating between mammalian hosts and hematophagous arthropod vectors
http://purl.obolibrary.org/obo/HP_0430081	Anti-Bartonella henselae antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against a component of Bartonella.
http://purl.obolibrary.org/obo/HP_0430082	Anti-Dengue virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of Dengue virus.
http://purl.obolibrary.org/obo/HP_0430083	Anti-arbovirus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of an Arbovirus.
http://purl.obolibrary.org/obo/HP_0430084	Anti-lymphocytic choriomeningitis antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of lymphocytic choriomeningitis virus (LCMV).
http://purl.obolibrary.org/obo/HP_0430085	Anti-varicella-zoster antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of Varicella-zoster virus.
http://purl.obolibrary.org/obo/HP_0430086	Anti-rubella antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of rubella virus.
http://purl.obolibrary.org/obo/HP_0430087	Anti-cytomegalovirus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of cytomegalovirus (CMV).
http://purl.obolibrary.org/obo/HP_0430088	Anti-measles antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of measles virus.
http://purl.obolibrary.org/obo/HP_0430089	Anti-schistosoma antibody positivity	http://purl.obolibrary.org/obo/HP_0430060	Bloodstream parasite-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of a parasite of the genus Schistosomiasis is a parasitic disease historically known as bilharzia caused by the trematode of the genus Schistosoma. Schistosomiasis is a parasitic disease historically known as bilharzia caused by the trematode of the genus Schistosoma.
http://purl.obolibrary.org/obo/HP_0430090	Anti-Powassan virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430083	Anti-arbovirus antibody positivity		The presence of antibodies in the blood circulation that react against a component of a Powassan virus (POW), which is an arbovirus within the family of Flaviviruses primarily found in the Northeastern United States, Canada, and Russia. It is a zoonotic infection transmitted to humans by several tick species and is the only member of the tick-borne flaviviruses endemic to North America.
http://purl.obolibrary.org/obo/HP_0430091	Marker expression	http://purl.obolibrary.org/obo/HP_0020228	Biospecimen phenotypic feature		Detection of a marker such as a protein by immunohistochemistry or related investigation techniques. The presence or absence of such markers can be used to identify cell types on the basis of a profile of expressed markers. These terms do not imply abnormality and can be used for any cell type or organ.
http://purl.obolibrary.org/obo/HP_0430092	BCL2 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of BCL2 on the cell(s) of interest with the use of anti-BCL2 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430093	BCL6 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of BCL6 on the cell(s) of interest with the use of anti-BCL6 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430094	CD5 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD5 on the cell(s) of interest with the use of anti-CD5 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430095	CD10 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD10 on the cell(s) of interest with the use of anti-CD10 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430096	CD23 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD23 on the cell(s) of interest with the use of anti-CD23 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430097	CD38 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD38 on the cell(s) of interest with the use of anti-CD38 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430098	CD45 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD45 on the cell(s) of interest with the use of anti-CD45 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430099	Cyclin D1 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of cyclin D1 on the cell(s) of interest with the use of anti-cyclin D1 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430100	FMC7 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of FMC7 on the cell(s) of interest with the use of anti-FMC7 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430101	CD19 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD19 on the cell(s) of interest with the use of anti-CD19 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_0430102	CD20 expression	http://purl.obolibrary.org/obo/HP_0430091	Marker expression		Detection of the presence of CD20 on the cell(s) of interest with the use of anti-CD20 antibodies conjugated to a chromogen (for immunohistochemistry) or fluorophore (for flow cytometry).
http://purl.obolibrary.org/obo/HP_6000172	Tympanic membrane bulging	http://purl.obolibrary.org/obo/HP_0040090	Abnormal tympanic membrane morphology		The tympanic membrane protrudes (swells outwards). This feature may be observed with otoscopy.
http://purl.obolibrary.org/obo/HP_6000173	Ear pain exacerbated by manipulating tragus or pinna	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applies to pain of the ear that is worsened, aggravated, or exacerbated by touching or moving the tragus or pinna.
http://purl.obolibrary.org/obo/HP_6000174	Lateral neck mass	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		An abnormal enlargement or swelling localized to the side of the neck. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000175	Occipital location	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in the occiput (back part of the head).
http://purl.obolibrary.org/obo/HP_6000176	Anterior neck swelling	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Abormal enlargement of the front part of the neck owing to accumulation of fluid.
http://purl.obolibrary.org/obo/HP_6000177	Uvular swelling	http://purl.obolibrary.org/obo/HP_0000172	Abnormal uvula morphology		Abnormal enlargement of the uvula related to an abnormal accumulation of fluid.
http://purl.obolibrary.org/obo/HP_6000179	History of gastric bypass surgery	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		History of having received gastric bypass surgery. This is a procedure that reduces the functional volume of the stomach and is used to treat morbid obesity.
http://purl.obolibrary.org/obo/HP_6000180	Triggered by volatile organic compounds	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure to volatile organic compounds (VOCs), which comprise various organic chemicals which are released as gases from different liquids or solids.
http://purl.obolibrary.org/obo/HP_6000181	History of radiation therapy	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A medical history of having undergone radiation therapy, which is a treatment that uses ionizing radiation for purposes such as the control the growth of malignant cells in cancer treatment.
http://purl.obolibrary.org/obo/HP_6000182	Absent otoacoustic emissions	http://purl.obolibrary.org/obo/HP_0031704	Abnormal ear physiology		Failure to record otoacoustic emissions (OAE), i.e., sounds generated from the cochlea in response to an acoustic stimulus and transmitted across the middle ear to the external ear canal.
http://purl.obolibrary.org/obo/HP_6000183	Thickened tympanic membrane	http://purl.obolibrary.org/obo/HP_0040090	Abnormal tympanic membrane morphology		The tympanic membrane (eardrum, myringa) is a thin, semitransparent, oval membrane, approximately 1 cm in diameter, that separates the external acoustic meatus from the tympanic cavity. Thickening refers to an increase of the dimension across the membrane.
http://purl.obolibrary.org/obo/HP_6000184	Filum terminale lipoma	http://purl.obolibrary.org/obo/HP_6000590	Spinal lipoma		Filum terminale lipomas (FTLs) are a type of lumbosacral lipoma in which the fat is entirely within the filum terminale and separate from the conus medullaris.
http://purl.obolibrary.org/obo/HP_6000185	Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio	http://purl.obolibrary.org/obo/HP_0011731	Abnormality of circulating cortisol level		The relative concentration of tetrahydrocortisol plus 5-alpha-tetrahydrocortisol relative to that of tetrahydrocortisone is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000186	Anti-soluble liver antigen/liver pancreas antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against soluble liver antigen.
http://purl.obolibrary.org/obo/HP_6000187	Anti-thrombospondin type I domain-containing 7A antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against thrombospondin type I domain-containing 7A.
http://purl.obolibrary.org/obo/HP_6000188	Antisperm antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against sperm antigens.
http://purl.obolibrary.org/obo/HP_6000189	Decreased circulating ficolin-3 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of ficolin-3 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000190	Abnormal seminal vesicle morphology	http://purl.obolibrary.org/obo/HP_0000022	Abnormal male internal genitalia morphology		A structural abnormality of the seminal vesicle. The seminal vesicles are a pair of glands that also include the prostate gland and the bulbourethral glands and are located in the pelvis superior to the rectum, inferior to the fundus of the bladder and posterior to the prostate. The seminal vesicles contribute around 70% of the fluid that will eventually become semen.
http://purl.obolibrary.org/obo/HP_6000191	Seminal vesicle cyst	http://purl.obolibrary.org/obo/HP_6000190	Abnormal seminal vesicle morphology		A cyst (sac-like mass that may contain serous liquid or semisolid material) caused by distention of the seminal vesicle due to atresia of the ejaculatory duct.
http://purl.obolibrary.org/obo/HP_6000192	Silica dust exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of exposure to respirable crystalline silica (SiO2).
http://purl.obolibrary.org/obo/HP_6000193	Anti-osteoprotegerin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against osteoprotegerin.
http://purl.obolibrary.org/obo/HP_6000194	History of adrenalectomy	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		A past medical history of having had a surgical procedure to remove the adrenal glands.
http://purl.obolibrary.org/obo/HP_6000195	Elevated mitochondrial citrate synthase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the enzyme mitochondrial citrate synthase (EC:2.3.3.1) in muscle tissue is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000196	Reduced muscle lactate dehydrogenase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the enzyme lactate dehdrogenase (LHD; 1.1.1.27) in muscle tissue is below the lower limit of normal. LDH catalyzes the conversion of pyruvate to lactate and back, as it converts NAD+ to NADH and back.
http://purl.obolibrary.org/obo/HP_6000197	Reduced muscle phosphoglycerate mutase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the enzyme Phosphoglycerate mutase (PGM) in muscle tissue is below the lower limit of normal. PGM is an enzyme that catalyzes step 8 of glycolysis (EC 5.4.2.11).
http://purl.obolibrary.org/obo/HP_6000198	Reduced muscle phosphorylase kinase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the enzyme muscle phosphorylase kinase (PhK) in muscle tissue below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000199	Reduced 3-beta-hydroxysteroid-delta-5-desaturase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of 3-beta-hydroxysteroid-delta-5-desaturase, also known as Sterol C5-desaturase (EC 1.3.3.2), or SC5D below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000200	Reduced hepatic glucose-6-phosphatase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of glucose-6-phosphatase (EC 3.1.3.9) in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000201	Reduced hepatic glucose-6-phosphate translocase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of glucose-6-phosphate translocase in liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000202	Cerebrospinal fluid erythrocytes	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		The presence of red blood cells (RBCs) in the cerebrospinal fluid (CSF). The CSF normally does not contain RBCs (erythrocytes).
http://purl.obolibrary.org/obo/HP_6000203	Elevated CSF cholestanol concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of cholestanol in the cerebrospinal fluid (CSF) is above the upper limit of normal. Cholestanol is the 5-alpha-dihydro derivative of cholesterol.
http://purl.obolibrary.org/obo/HP_6000204	Elevated CSF apolipoprotein B concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of apolipoprotein B in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000205	Elevated CSF myelin basic protein concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		The concentration of myelin basic protein in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000206	Reduced CSF pyridoxal-5'-phosphate concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of pyridoxal-5'-phosphate in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000207	Elevated CSF thymine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of thymine in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000208	Elevated CSF 5-hydroxymethyluracil concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of 5-hydroxymethyluracil in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000209	Elevated CSF N-carbamyl-beta-aminoisobutyric acid concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of N-carbamyl-beta-aminoisobutyric acid in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000210	Elevated CSF N-carbamyl-beta-alanine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of N-carbamyl-beta-alanine in the cerebrospinal fluid is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000211	Elevated CSF dihydrouracil concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of dihydrouracil in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000212	Elevated CSF dihydrothymine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of dihydrothymine in the cerebrospinal fluid is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000213	Elevated circulating angiotensin-converting enzyme concentration	http://purl.obolibrary.org/obo/HP_0011021	Abnormal circulating enzyme concentration		The concentration of angiotensin-converting enzyme in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000214	Decreased 3-hydroxyisobutyrate dehydrogenase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of 3-hydroxyisobutyrate dehydrogenase in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000215	Reduced circulating 3-hydroxyisobutyryl-CoA hydrolase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of 3-hydroxyisobutyryl-CoA hydrolase in the blood corculation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000216	Reduced HMG-CoA lyase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of 3-hydroxy-3-methylglutaryl coenzyme A lyase (HMG CoA lyase) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000217	Reduced circulating acyl-CoA oxidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of acyl-CoA oxidase activity in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000218	Reduced circulating xanthine oxidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme xanthine oxidase (EC 1.17.3.2) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000219	Reduced methylmalonate semialdehyde dehydrogenase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		The activity of methylmalonate semialdehyde dehydrogenase ( EC 1.2.1.27) in cultured fibroblasts is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000220	Pharyngeal mass	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		An abnormal enlargement or swelling localized to the pharynx (i.e., the throat, the space that connects the nose and mouth to the larynx and esophagus). The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000221	Positive stool occult blood test	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		The presence of hidden (occult) blood in the stool.
http://purl.obolibrary.org/obo/HP_6000222	Painful defecation	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort that occurs when passing stool.
http://purl.obolibrary.org/obo/HP_6000223	Recent history of caustic substance ingestion	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of a recent ingestion of a caustic substance, i.e., a highly acidic or alkaline chemicals that can cause severe burns to the mouth and digestive tract when swallowed.
http://purl.obolibrary.org/obo/HP_6000224	Delayed passage of meconium	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		Failure to pass meconium (the first stool following birth) in the first 48 hours of life.
http://purl.obolibrary.org/obo/HP_6000225	Single second heart sound	http://purl.obolibrary.org/obo/HP_0031661	Abnormal second heart sound		The second sound can remain single throughout the respiratory cycle due to either absence of one component or to synchronous occurrence of the two components. Since the pulmonary vascular impedance increases with age, many normal patients over age 50 have a single S2 or at most a narrow physiologic split on inspiration because P2 occurs early. A single second sound, however, is usually due to inability to auscultate a relatively soft pulmonic component. Such inability is rare in healthy infants, children, and young adults and is uncommon even in older persons under good auscultatory conditions using a rigid stethoscopic diaphragm.
http://purl.obolibrary.org/obo/HP_6000226	Elevated aortic transvalvular pressure gradient	http://purl.obolibrary.org/obo/HP_0030964	Abnormal aortic physiology		The gradient (in this case, drop) in pressure across the aortic valve is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000227	Prosthetic heart valve	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		A past surgical history of the implanation of an artificial heart valve.
http://purl.obolibrary.org/obo/HP_6000228	Failure to increase oxygen saturation on hyperoxia test	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Hyperoxia test is the initial method to distinguish critical congenital heart disease (CCHD) from pulmonary disease. The test consists in measuring an arterial blood gas at room air and 100% inspired oxygen after 10 minutes. Neonates with congenital heart disease are usually not able to increase PaO2 above 100 mm Hg during 100% oxygen administration. In patients with pulmonary disease, PaO2 generally increased greater than or equal to 100 mm Hg with 100% oxygen as ventilation-perfusion discrepancies are overcome. A positive result indicates the cardiac origin and further cardiac workup is indicated to rule out CCHD.
http://purl.obolibrary.org/obo/HP_6000229	High-set nipples	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		Placement of the nipples at a higher than normal location.
http://purl.obolibrary.org/obo/HP_6000230	Decreased muscle caveolin-3 level	http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration		The amount of calveolin-3 in muscle tissue is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity	http://purl.obolibrary.org/obo/HP_0034684	Abnormal enzyme concentration or activity		Concentration of an enyzme in a tissue is above or between the limit of normal. This term is intended to be used for enzymes that can be measured in multiple tissues other than blood.
http://purl.obolibrary.org/obo/HP_6000232	Splenic necrosis	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Cell dealth (necrosis) located in the spleen.
http://purl.obolibrary.org/obo/HP_6000233	Carcinoid tumor of the pancreas	http://purl.obolibrary.org/obo/HP_0002894	Neoplasm of the pancreas		A carcinoid tumor of the pancreas (CTP) is a rare neuroendocrine tumor arising from the serotonin-secreting cells (enterochromaffin or Kultscitsky's cells).
http://purl.obolibrary.org/obo/HP_6000234	Elevated circulating dihydroxyphenylacetic acid concentration	http://purl.obolibrary.org/obo/HP_0033405	Abnormal circulating organic amino compound concentration		The concentration of dihydroxyphenylacetic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000235	Inappropriately low concentration of acetoacetate	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		Lower than appropriate concentration of acetoacetate in states such as hypoglycemia in which the normal response would be to elevate acetoacetate.
http://purl.obolibrary.org/obo/HP_6000236	Inappropriately low concentration of beta-hydroxybutyrate	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		Lower than appropriate concentration of beta-hydroxybutyrate in states such as hypoglycemia in which the normal response would be to elevate acetoacetate.
http://purl.obolibrary.org/obo/HP_6000237	Elevated circulating 3-hydroxybutyryl-carnitine concentration	http://purl.obolibrary.org/obo/HP_0035016	Elevated circulating C4-acylcarnitine concentration		Concentration of 3-hydroxybutyryl-carnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000238	Elevated CSF 5-amino-4-imidazolecarboxyamide concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of 5-amino-4-imidazolecarboxyamide in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000239	Elevated circulating tumor necrosis factor alpha concentration	http://purl.obolibrary.org/obo/HP_0011112	Abnormal circulating cytokine concentration		The concentration of tumor necrosis factor alpha in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000240	Reduced circulating pyrimidine 5-prime-nucleotidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity of concentration of pyrimidine 5-prime-nucleotidase (EC 3.1.3.5) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000241	Diminished prolactin response to thyrotrophin-releasing hormone stimulation	http://purl.obolibrary.org/obo/HP_0033080	Abnormal TSH response to thyrotrophin-releasing hormone stimulation test		The increase in prolactin concentration (PRL) following stimulation with thyrotropin (thyrdoid releasing hormone) as compared to baseline PRL concentration is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000242	Decreased circulating complement component 1s concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		The concentration of complement component 1s (C1s) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000243	Decreased circulating corticosteroid-binding globulin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of corticosteroid-binding globulin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000244	Decreased circulating thyroglobulin concentration	http://purl.obolibrary.org/obo/HP_0025483	Abnormal circulating thyroglobulin concentration		The concentration of thyroglobulin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000245	Elevated circulating granulocyte-macrophage colony-stimulating factor concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of granulocyte-macrophage colony-stimulating factor in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000246	Elevated CSF D-2-hydroxyglutaric acid concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		The concentration of D-2-hydroxyglutaric acid in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000247	Esophageal mass	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		A swelling or enlargement localized to the esophagus. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000248	Bursa fluid crystals	http://purl.obolibrary.org/obo/HP_0025231	Abnormal synovial bursa morphology		The presence of crystals (microscopic solids that form distinct lattices, with definable fixed angles, faces, walls) in the bursa fluid.
http://purl.obolibrary.org/obo/HP_6000249	Enlarged gastric folds	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		Giant gastric folds are recognized at endoscopy as an increase in the size of the gastric rugae and a lack of flattening.
http://purl.obolibrary.org/obo/HP_6000250	Gastric intraepithelial lymphocytosis	http://purl.obolibrary.org/obo/HP_0004295	Abnormal gastric mucosa morphology		The count of lymphocytes located in the epithelial layer of the gastric mucosa is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000251	Small intestinal intraepithelial lymphocytosis	http://purl.obolibrary.org/obo/HP_0025129	Abnormal small intestinal mucosa morphology		The count of lymphocytes located in the epithelial layer of the mucosa of the small intestine is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000252	Fetal lung hyperechogenicity	http://purl.obolibrary.org/obo/HP_0034243	Abnormal fetal pulmonary morphology		Increased response (echo) of lung tissue of a fetus observed on prenatal sonography. Increased echo response is conventially displayed as a higher degree of brightness.
http://purl.obolibrary.org/obo/HP_6000253	Necrotizing vasculitis	http://purl.obolibrary.org/obo/HP_0034785	Vasculitis by histology		A histopathological finding characterized by inflammation of the arterial and/or capillary and/or venous blood vessels, leading to a change in the vascular wall as a whole.
http://purl.obolibrary.org/obo/HP_6000254	Abnormal proximal convoluted tubule morphology	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Any structural anomaly of the proximal convoluted tubule, which is the first tubular component of the nephron and arises as a continuation of the Bowman space from the tubular pole of the renal corpuscle. The proximal convoluted tubule is located within the renal cortex.
http://purl.obolibrary.org/obo/HP_6000255	Demonstration of Leishmania in tissue	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Presence of Leishmania, a parasitic protozoan, in a tissue specimen. Leishmania is responsible for leishmaniasis.
http://purl.obolibrary.org/obo/HP_6000256	Pneumocystis cysts in respiratory secretions	http://purl.obolibrary.org/obo/HP_0430107	Sputum infectious agent		Demonstration of cysts of Pneumocystis (a genus of related fungal species) in respiratory secretions such as nasopharyngeal secretions or pleural fluid.
http://purl.obolibrary.org/obo/HP_6000257	Spinal cord granuloma	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		An aggregation of macrophages (forming in response to chronic inflammation) localized in or on the spinal cord.
http://purl.obolibrary.org/obo/HP_6000258	Impaired folate absorption	http://purl.obolibrary.org/obo/HP_0100508	Abnormality of vitamin metabolism		Reduced ability to absorb folate in the diet. This finding can be measured by a folic acid loading test in which blood concentration of folate is measured after oral administration of folic acid.
http://purl.obolibrary.org/obo/HP_6000259	Positive hydrogen breath test	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		Abnormally elevated quantiy of hydrogen measured by a hydrogen breath test (HBT). HBTs administer substrates such as glucose, lactulose, lactose and fructose and subsequently measure hydrogen exhaled in the breath using a gas chromatograph.
http://purl.obolibrary.org/obo/HP_6000260	History of recent plant thorn skin puncture	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A history of a plant skin puncture preceding the current presenting condition by hours, days, or weeks.
http://purl.obolibrary.org/obo/HP_6000261	Absent circulating kappa chain-bearing immunoglobulin	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		Nondetectable kappa chain in the blood circulation.
http://purl.obolibrary.org/obo/HP_6000262	Pseudoglioma	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		A circumscribed whitish-yellow mass in the posterior chamber associated with retinal folds and sometimes retinal detachment and is said to resemble a retinal glioma.
http://purl.obolibrary.org/obo/HP_6000263	Papillary dermal edema	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		Swelling due to fluid acculuation of the papillary dermis.
http://purl.obolibrary.org/obo/HP_6000264	Fetal tachycardia	http://purl.obolibrary.org/obo/HP_0001649	Tachycardia		The number of beats per minute (bpm) of the fetal heart is above the upper limit of the normal for the gestational age. Fetal tachycardia is thus defined as a heart rate greater than 160-180 bpm.
http://purl.obolibrary.org/obo/HP_6000265	Elevated urinary 3-hydroxykynurenine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of 3-hydroxykynurenine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000266	2-oxoadipic aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The amount of 2-oxoadipic acid in the urine, normaliyed for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000267	Elevated circulating methionine sulfoxide concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		The concentration of methionine sulfoxide in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000268	Elevated circulating pipecolic acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of pipecolic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000269	Elevated urinary pipecolic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		The amount of pipecolic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000270	Elevated CSF saccharopine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Concentration of saccharopine in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000271	Elevated circulating glycylproline concentration	http://purl.obolibrary.org/obo/HP_0033386	Abnormal circulating collagen degradation product concentration		Concentration in the bloodstream of glycylproline above the upper limit of normal. Glycylproline is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9).
http://purl.obolibrary.org/obo/HP_6000272	Elevated circulating octanoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration		The concentration of octanoylcarnitine (C8:0) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000273	Elevated circulating decanoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration		The concentration of decanoylcarnitine (C10:0) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000274	2--hydroxyphenylacetic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Increased concentration of 2-hydroxyphenylacetic acid in the urine.
http://purl.obolibrary.org/obo/HP_6000275	4-hydroxyphenyllactic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Amount of 4-hydroxyphenyllactic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/UBERON_8850000	lumen of pulmonary alveolus	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		An anatomical cavity that is part of the alveolus of the lung
http://purl.obolibrary.org/obo/HP_0025737	Abnormal subthalamic nucleus morphology	http://purl.obolibrary.org/obo/HP_0010662	Abnormal diencephalon morphology		Any structural anomaly of the subthalamic nucleus, a small lens-shaped structure located within the diencephalon near the junction with the midbrain. The subthalamic nucleus composes the majority of the subthalamus along with the subthalamic fasciculus, ansa lenticularis, and several other smaller structures.
http://purl.obolibrary.org/obo/HP_0025738	Ring-enhancing cerebral lesion	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		An abnormal neuroimaging finding consisting in an area of decreased density surrounded by a bright rim from concentration of the enhancing contrast dye.
http://purl.obolibrary.org/obo/HP_0025739	Optic nerve mass	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		A swelling or enlargement localized to the optic nerve. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0025740	Elevated brain succinate level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An increase in the level of succinate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025741	Brainstem lucency	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		A lesion located in the brainstem that appears areas less dense on magnetic resonance imaging or lighter on computed tomography.
http://purl.obolibrary.org/obo/HP_0025742	Elevated urine L-xylulose level	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		The amount of L-xylulose in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025743	Elevated urine biliverdin level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The amount of biliverdin in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025744	Elevated urine dodecanedioic acid level	http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria		The amount of dodecanedioic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025746	Diminished urine glutamine level	http://purl.obolibrary.org/obo/HP_0025745	Abnormal urine amino acid level		The amount of glutamine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025747	Tongue spasticity	http://purl.obolibrary.org/obo/HP_0000182	Movement abnormality of the tongue		Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the tongue.
http://purl.obolibrary.org/obo/HP_0025748	Restricted tongue movement	http://purl.obolibrary.org/obo/HP_0000182	Movement abnormality of the tongue		Limited ability to move the tongue related to mechanical restrictions such as akyloglossia and not associated with tongue muscle weakness.
http://purl.obolibrary.org/obo/HP_0025749	Asymmetric blood pressure between limbs	http://purl.obolibrary.org/obo/HP_0030972	Abnormal systemic blood pressure		A substantial difference in blood pressure (e.g., 20 mmHg) between the right and left limb (arm or leg or both).
http://purl.obolibrary.org/obo/HP_0025750	Asymmetric blood pressure between legs	http://purl.obolibrary.org/obo/HP_0025749	Asymmetric blood pressure between limbs		A substantial difference in blood pressure (e.g., 20 mmHg) between the right and left legs.
http://purl.obolibrary.org/obo/HP_0025751	Reduced anterior scleral thickness	http://purl.obolibrary.org/obo/HP_6000841	Abnormal scleral thickness		A reduction in the height of the anterior portion of the sclera.
http://purl.obolibrary.org/obo/HP_0025752	Reduced posterior scleral thickness	http://purl.obolibrary.org/obo/HP_6000841	Abnormal scleral thickness		A reduction in the height of the posterior portion of the sclera.
http://purl.obolibrary.org/obo/HP_0025753	Elevated urinary 2-aminoisobutyric acid	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of 2-aminoisobutyric acid in the urine, when normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025754	Reduced beta-hexosaminidase A activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The concentration or activity of beta hexosaminidase A in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025755	Abnormal nail shape	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		An abnormality affecting the outline (shape) or contour of the nail.
http://purl.obolibrary.org/obo/HP_0025758	Characteristic of mass	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		A mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction. This term refers to a property (characteristic) of a mass.
http://purl.obolibrary.org/obo/HP_0025759	Mobile lump	http://purl.obolibrary.org/obo/HP_0025758	Characteristic of mass		This modifier is applied to a palpable mass or swelling in the body that can be moved or shifted under the skin when pressed or manipulated.
http://purl.obolibrary.org/obo/HP_0025760	Immobile lump	http://purl.obolibrary.org/obo/HP_0025758	Characteristic of mass		This modifier is applied to a palpable mass or swelling in the body that cannot be moved or shifted under the skin when pressed or manipulated.
http://purl.obolibrary.org/obo/HP_0025761	Painless mass	http://purl.obolibrary.org/obo/HP_0025758	Characteristic of mass		This modifier is applied to a palpable mass or swelling in the body that does not elicit pain upon palpation.
http://purl.obolibrary.org/obo/HP_0025762	Anti-ganglionic acetylcholine receptor antibody positivity	http://purl.obolibrary.org/obo/HP_6001064	Anti-acetylcholine receptor antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against acetylcholine receptors of the ganglionic type.
http://purl.obolibrary.org/obo/HP_0025763	Positive urine anion gap	http://purl.obolibrary.org/obo/HP_0032943	Abnormal urine pH		The urine anion gap (UAG), calculated as [(Na+ + K+) - (Cl-)] has been used to roughly estimate whether urine ammonium is increased or decreased in the evaluation of hyperchloremic metabolic acidosis. The more ammonium in the urine, the lower the UAG is, which achieves negative values within a wide range (0 to -200 mEq/L) during hyperchloremic metabolic acidosis. In patients with distal renal tubular acidosis (RTA) of several etiologies, the UAG is positive, despite the prevailing metabolic acidosis, and this is a useful bedside diagnostic index of impaired ammonium excretion.
http://purl.obolibrary.org/obo/HP_0025764	Nasoethmoidal encephalocele	http://purl.obolibrary.org/obo/HP_0007330	Frontoethmoidal encephalocele		A type of encephalocele that is characterized by herniation through the foramen cecum into the prenasal space and nasal cavity under the nasal bones and above the nasal septum.
http://purl.obolibrary.org/obo/HP_0025765	Rubber-like lump	http://purl.obolibrary.org/obo/HP_0025758	Characteristic of mass		This modifier is applied to a palpable mass or swelling in the body that has a rubber-like consistency, that is, it is soft and somewhat compressible.
http://purl.obolibrary.org/obo/HP_0025766	Abnormal affect	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		An anomaly in intensity, frequency, or duration of the verbal or behavioral expression of emotions, feelings, or thoughts.
http://purl.obolibrary.org/obo/HP_0025769	Disordered formal thought process	http://purl.obolibrary.org/obo/HP_0025792	Abnormal cognitive process		An abnormality in the dynamic mode, rate, or form of thought processes as recognized from the flow of ideas expressed in speech. Successive thoughts and speech are easily diverted by external stimuli or internal superficial associations. Unable to maintain a constant train of thought and loose themselves in side issues, losing the thread and are unable to recover it. Superficial connections appear to drive the subject matter.
http://purl.obolibrary.org/obo/HP_0025771	Ruminations	http://purl.obolibrary.org/obo/HP_0025785	Abnormal preoccupation		Recurrent thoughts that have a thematic thread that is typically familiar to the individual and are often willfully brought forth or occur in the context of an anxious preoccupation or worry about a relevant concern which may be out of proportion to the context. Ruminations may be of normal thinking rate and are characterized by a recurring theme that usually has a negative connotation.
http://purl.obolibrary.org/obo/HP_0025772	Abnormal lexical patterns	http://purl.obolibrary.org/obo/HP_4000072	Abnormal language feature		A persistent abnormality in patterns or meanings of expressed language. Words and phrases are disorganized in relationship to each other and often used incorrectly or inappropriately for the context and background culture of the person.
http://purl.obolibrary.org/obo/HP_0025773	Abnormal semantics	http://purl.obolibrary.org/obo/HP_0025772	Abnormal lexical patterns		Odd use of words that are out of context and inappropriate for the social situation.
http://purl.obolibrary.org/obo/HP_0025774	Idiosyncratic use of words	http://purl.obolibrary.org/obo/HP_0025773	Abnormal semantics		Words or phrases and their expression that are used in a manner that is not consistent with the current and accepted meaning for the context and social circumstance. This does not apply to peer or culture driven novel uses of words that are accepted within the given social circles.
http://purl.obolibrary.org/obo/HP_0025775	Tangential speech	http://purl.obolibrary.org/obo/HP_0025773	Abnormal semantics		Patterns of expressed speech that have many words to describe a feature, but are themselves vague and approximations. The speech does not get to the point, but rather seems to go around and around and is inconcise and difficult to grasp the primary issue or purpose of the communicated words.
http://purl.obolibrary.org/obo/HP_0025776	Thought insertion	http://purl.obolibrary.org/obo/HP_5200419	Disorder of thought control		The experience that thoughts are forced into the conscious awareness by external and foreign entities. The affected individual typically does not recognize the thoughts as coming from themselves and may develop secondary delusional ideas to explain the source of the process.
http://purl.obolibrary.org/obo/HP_0025777	Thought broadcasting	http://purl.obolibrary.org/obo/HP_5200419	Disorder of thought control		The experience that thoughts are being broadcasted from their head/conscious experience, some report that their thoughts are escaping, while others may believe that their thoughts are being picked up by a nearby receiver only to be further propagated. The person subsequently believes that everyone knows what they are thinking and feels that they have no privacy.
http://purl.obolibrary.org/obo/HP_0025778	Thought echo	http://purl.obolibrary.org/obo/HP_5200419	Disorder of thought control		The personal experience that thoughts are echoing around them and that they are hearing their own thoughts as they are experiencing them internally.
http://purl.obolibrary.org/obo/HP_0025781	Abnormally rapid thought process	http://purl.obolibrary.org/obo/HP_0025769	Disordered formal thought process		Increased rate or speed of thoughts.
http://purl.obolibrary.org/obo/HP_0025782	Abnormal syntax	http://purl.obolibrary.org/obo/HP_0025772	Abnormal lexical patterns		Persistent abnormalities in sentence structure exceeding that of the context and background culture of the person.
http://purl.obolibrary.org/obo/HP_0025784	Word salad	http://purl.obolibrary.org/obo/HP_0002463	Language impairment		Speech that consists of a series of recognizable words that are randomly strung together with no meaningful connection.
http://purl.obolibrary.org/obo/HP_0025785	Abnormal preoccupation	http://purl.obolibrary.org/obo/HP_0025779	Disorder of thought content		Preoccupations refers to being absorbed in any particular thought, activity, or concern that captures the attention of the individual. It may have a positive or negative connotation.
http://purl.obolibrary.org/obo/HP_0025786	Intraosseous lipoma	http://purl.obolibrary.org/obo/HP_0012032	Lipoma		Intraosseous lipomas are rare benign lesions composed of mature fat that reside within the intramedullary canal.
http://purl.obolibrary.org/obo/HP_0025787	Paraphilia	http://purl.obolibrary.org/obo/HP_0008768	Abnormal sexual behavior		Intense and typically recurring sexual arousal to atypical objects, fantasies, places, or individuals that frequently, but not always, lead to engagement of non-conventional sexual acts. This is a broad class of desires and behaviors that may include innocuous fetish behavior to illegal behaviors involving non-consenting individuals.
http://purl.obolibrary.org/obo/HP_0025788	Radiographic modifier	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		A characteristic of a lesion on radiography.
http://purl.obolibrary.org/obo/HP_0025789	Radiolucent	http://purl.obolibrary.org/obo/HP_0025788	Radiographic modifier		Applies to a lesion that allows x-rays to penetrate through them and expose the receptor (radiolucency). Soft tissues appear black or dark on the processed radiograph and are called radiolucent.
http://purl.obolibrary.org/obo/HP_0025790	Radiodense	http://purl.obolibrary.org/obo/HP_0025788	Radiographic modifier		Applies to a lesion that attenuates X-rays and appears radiodense (white) on a radiograph.
http://purl.obolibrary.org/obo/HP_0025791	Delusion of guilt	http://purl.obolibrary.org/obo/HP_0000746	Delusion		Delusional belief of one's personal guilt for an event, real or imagined, and that one caused an outcome that is somehow catastrophic. It is generally impossible or fantastical that this could have happened in the manner believed by the person, that they were somehow responsible for an event despite not be anywhere near where it allegedly occurred.
http://purl.obolibrary.org/obo/HP_0025792	Abnormal cognitive process	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		An abnormal cognitive process can be defined as a deviation from the typical development, structural organization, or functional execution of mental operations that connect informational inputs to behavioral outputs, typically involve at least one of the following processes: perception, memory, learning, emotion, intentionality, self-representation, rationality, and decision-making.
http://purl.obolibrary.org/obo/HP_0025793	Abnormal change in sexual drive	http://purl.obolibrary.org/obo/HP_0025780	Abnormal volitional state		An abnormal change in libido (sexual desire), typically accompanied by an altered frequency of sexual activity compared to from a person's previous norm.
http://purl.obolibrary.org/obo/HP_6001034	Desmoid tumor	http://purl.obolibrary.org/obo/HP_0031459	Soft tissue neoplasm		Desmoid tumors are rare, locally aggressive, fibroblastic soft-tissue tumors that are characterized by infiltrative growth and tendency to recur. Desmoid tumors do not metastasize but can arise in any part of the body: extra-abdominal (appear in the head and neck, chest, extremities), and abdominal wall or intra-abdominal (originating in tissue that connects abdominal organs).
http://purl.obolibrary.org/obo/HP_6001064	Anti-acetylcholine receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against acetylcholine receptor.
http://purl.obolibrary.org/obo/HP_6001165	Abnormal retinal vein morphology	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		A condition characterized by structural abnormalities of the retinal veins, including tortuosity, dilation, narrowing, or irregularities in branching patterns. These changes may be associated with systemic or ocular diseases such as retinal vein occlusion, diabetic retinopathy, or hypertensive retinopathy.
http://purl.obolibrary.org/obo/HP_6001166	Spongiosis	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Spongiosis refers to the increased intercellular edema in the epidermis resulting in the pulling away of the keratinocytes from their surrounding desmosomes. Histologically, the spongiotic tissue reaction pattern involves the accumulation of fluid in the intercellular spaces of the epidermis, making the desmosomes junctions more easy to appreciate. Parakeratosis forms above the areas of spongiosis. The foci of spongiosis can be microscopic to grossly identifiable clinically with vesicles or bullae.
http://purl.obolibrary.org/obo/HP_6001167	Discoid adrenal gland	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		A congenital finding where the adrenal gland does not form it's typical triangular, Y or V shape and is instead discoid, straight or elongated in shape. It is often found incidentally on renal ultrasound and is associated with renal agenesis and other renal congenital anomalies.
http://purl.obolibrary.org/obo/HP_6001168	Abnormal optic disc vasculature morphology	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		A structural abnormality in the blood vessels of the optic disc, including bleeding, tortuosity, dilation, shunting, or other unusual branching patterns.
http://purl.obolibrary.org/obo/HP_6001169	Supraclavicular nerve distribution	http://purl.obolibrary.org/obo/HP_0025849	Localized along nerve distribution		Localization of symptoms such as numbness or paresthesias on the skin over the upper chest, specifically above the clavicle and over the lateral aspect of the neck, corresponding to the distribution of the supraclavicular nerve.
http://purl.obolibrary.org/obo/HP_6001170	Limited shoulder internal rotation	http://purl.obolibrary.org/obo/HP_0006467	Limited shoulder movement		Difficulty rotating the lower part of the arm towards the body (tested with the elbow flexed and the elbow held next to the side of the body or shoulder 90 degrees abducted to the side) secondary to pain, weakness, or mechanical block.
http://purl.obolibrary.org/obo/HP_6001171	Superior displacement of the humeral head	http://purl.obolibrary.org/obo/HP_0003887	Abnormal humeral head morphology		An anterior posterior (AP) shoulder radiograph shows distance between the the proximal aspect of the humeral head and inferior aspect of the acromion of less than 7 mm.
http://purl.obolibrary.org/obo/HP_6001172	Increased compartment pressure	http://purl.obolibrary.org/obo/HP_0011804	Abnormal muscle physiology		intracompartmental pressure (ICP) over 30 mmHg. Acute compartment syndrome occurs when there is increased pressure within a closed osteofascial compartment, resulting in impaired local circulation. Acute compartment syndrome is considered a surgical emergency since, without proper treatment, it can lead to ischemia and eventually necrosis. Generally, acute compartment syndrome is considered a clinical diagnosis. However, ICP over 30 mmHg can be used as a threshold to aid in diagnosis.
http://purl.obolibrary.org/obo/HP_6001173	Pain at the lateral aspect of the elbow	http://purl.obolibrary.org/obo/HP_0030835	Elbow pain		Pain localized to the radial aspect of the elbow.
http://purl.obolibrary.org/obo/HP_6001174	Pain at the posterior aspect of the elbow	http://purl.obolibrary.org/obo/HP_0030835	Elbow pain		Pain localized to the posterior aspect of the elbow.
http://purl.obolibrary.org/obo/HP_6001175	Pain at the medial aspect of the elbow	http://purl.obolibrary.org/obo/HP_0030835	Elbow pain		Pain localized to the medial aspect of the elbow.
http://purl.obolibrary.org/obo/HP_6001176	Radial nerve distribution	http://purl.obolibrary.org/obo/HP_0025849	Localized along nerve distribution		Applies to the localization of findings corresponding to the distribution of the radial nevrve, such as (i)paresthesias on the dorsoradial aspect of the hand and wrist, including the dorsal thumb, index finger and middle finger and (ii) Weakness in elbow extension, wrist extension, finger extension, thumb extension and/or supination of the forearm.
http://purl.obolibrary.org/obo/HP_6001177	Omovertebral bone	http://purl.obolibrary.org/obo/HP_0000782	Abnormal scapula morphology		An osseous connection between the superomedial border of the right scapula and C5-C6 spinous processes.
http://purl.obolibrary.org/obo/HP_6001178	Clavicular edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Swelling on the chest between the neck and the shoulder, above the clavicel (collar bone).
http://purl.obolibrary.org/obo/HP_6001179	Positive CSF anti-measles antibody test	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of measles virus.
http://purl.obolibrary.org/obo/HP_6001180	Vogt striae	http://purl.obolibrary.org/obo/HP_0011492	Abnormal corneal stroma morphology		Vertical lines in the posterior stroma of the cornea, aligned with Descemet membrane. These lines temporarily disappear with pressure applied to the cornea. Vogt striae are a hallmark feature of keratoconus but have also been observed in healthy eyes. Rare cases of horizontal striae have been reported.
http://purl.obolibrary.org/obo/HP_6001181	Choroid thickening	http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology		A condition characterized by an abnormal increase in the thickness of the choroid, which may be associated with various ocular or systemic conditions. Choroid thickening can be measured using imaging techniques such as optical coherence tomography (OCT).
http://purl.obolibrary.org/obo/HP_6001182	Corneal epithelial edema	http://purl.obolibrary.org/obo/HP_0011495	Abnormal corneal epithelium morphology		A condition characterized by accumulation of fluid within the corneal epithelium, leading to swelling, blurred vision, and discomfort. It is often associated with increased intraocular pressure, endothelial dysfunction, or contact lens overuse. Clinical features may include a hazy cornea and microcystic changes visible on slit-lamp examination.
http://purl.obolibrary.org/obo/HP_6001183	Retinal shunt vessels	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		bnormal blood vessels in the retina that form as a response to vascular occlusion, serving as bypass channels to redirect blood flow around obstructed or damaged retinal vessels. Retinal shunt vessels are often associated with conditions like retinal vein occlusion or diabetic retinopathy and may appear as tortuous or dilated vessels on fundoscopic examination.
http://purl.obolibrary.org/obo/HP_6001184	Filamentary keratitis	http://purl.obolibrary.org/obo/HP_0011495	Abnormal corneal epithelium morphology		A condition characterized by the formation of filaments composed of degenerated epithelial cells and mucus attached to the corneal surface. It is associated with symptoms such as pain, foreign body sensation, photophobia, and tearing. Filamentary keratitis is often linked to underlying conditions such as dry eye disease, post-surgical ocular surface disorders, or systemic diseases like Sjoegren syndrome.
http://purl.obolibrary.org/obo/HP_6001185	Elevated circulating glucosylsphingosine concentration	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		Concentration of D-glucosylsphingosine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001186	Optic disc hemorrhage	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		A condition characterized by bleeding at or near the optic disc, visible as a flame-shaped or splinter hemorrhage on fundoscopic examination.
http://purl.obolibrary.org/obo/HP_6001187	Decreased circulating progranulin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of progranulin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001188	Preauricular lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Enlargement of one or more lymph nodes located in front of the ear.
http://purl.obolibrary.org/obo/HP_6001189	Onychoheterotopia	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Growth of nail tissue outside the ungual plate, generally in the finger.
http://purl.obolibrary.org/obo/HP_6001191	Forward displacement of posterior cervical dura mater on neck flexion	http://purl.obolibrary.org/obo/HP_0410263	Brain imaging abnormality		Flexion MRI (imaging with neutral and flexed about 30-40 degrees neck position) reveals an anterior shift of the cervical dural sac from the lamina in the region of C4 to C7.
http://purl.obolibrary.org/obo/HP_6001192	Corneal dellen	http://purl.obolibrary.org/obo/HP_0100689	Decreased corneal thickness		A localized area of corneal thinning typically occurring adjacent to an elevated lesion, such as a conjunctival scar, pterygium, or poorly fitting contact lens. Corneal dellen result from tear film instability and localized dehydration. Without timely treatment, they may progress to epithelial defects or corneal ulceration.
http://purl.obolibrary.org/obo/HP_6001193	Conjunctival xerosis	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		A condition characterized by dryness of the conjunctiva, often associated with keratinization of the conjunctival epithelium. Conjunctival xerosis is commonly linked to vitamin A deficiency, severe dry eye disease, or systemic conditions such as Sjogren syndrome. Clinical features may include a dull, rough conjunctival surface and reduced mucosal secretions.
http://purl.obolibrary.org/obo/HP_6001194	Limited shoulder external rotation	http://purl.obolibrary.org/obo/HP_0006467	Limited shoulder movement		Difficulty rotating the lower part of the arm away from the body (tested with the elbow flexed and the elbow held next to the side of the body) secondary to pain, weakness, or mechanical block.
http://purl.obolibrary.org/obo/HP_6001195	Occupational exposure to frequent hand trauma	http://purl.obolibrary.org/obo/HP_0035010	Occupational exposure history		A history of exposure to repeated hand trauma as observed with occupations in which use of hands is frequent such as construction, food preparation and serving related occupations, and transportation and material moving occupations.
http://purl.obolibrary.org/obo/HP_6001196	Inability to fully extend finger at metacarpophalangeal joint	http://purl.obolibrary.org/obo/HP_0006135	Decreased finger mobility		An inability to fully extend the metacarpophalangeal (MCP) joint of a finger (extension of an MCP joint straightens the finger).
http://purl.obolibrary.org/obo/HP_6001197	Wrist arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		Inflammation of the wrist joint.
http://purl.obolibrary.org/obo/HP_6001198	Scapholunate interval widening	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		Widening of the space between the scaphoid and lunate on x-ray; scapholunate dissociation.
http://purl.obolibrary.org/obo/HP_6001199	FInger pulp localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality whose distribution is limited to or predominantly affects the fleshy mass on the volar (palmar) aspect of the digit, distal to the distal interphalangeal (DIP) joint (known as the pulp of the finger).
http://purl.obolibrary.org/obo/HP_6001200	Ulnar wrist pain	http://purl.obolibrary.org/obo/HP_0030836	Wrist pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ulnar side of the wrist.
http://purl.obolibrary.org/obo/HP_6001201	Lunotriquetral interval widening	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		Radiographic widening of the space between the lunate and triquetrum bones.
http://purl.obolibrary.org/obo/HP_6001202	Ulnar translocation of the carpus	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		Anteroposterior wrist radiograph showing ulnar translocation of the carpus from the distal radius with widening of the radial styloid-scaphoid space.
http://purl.obolibrary.org/obo/UBERON_8600138	stomach lamina propria	http://purl.obolibrary.org/obo/UBERON_0004780	gastrointestinal system lamina propria		The lamina propria that underlies the epithelial lining of the stomach.
http://purl.obolibrary.org/obo/CL_4052108	IgD-negative class switched memory B cell	http://purl.obolibrary.org/obo/CL_0001053	IgD-negative memory B cell		A class switched memory B cell that lacks IgD on the cell surface.
http://purl.obolibrary.org/obo/CL_4072104	fibrochondrocyte	http://purl.obolibrary.org/obo/CL_0000138	chondrocyte		A chondrocyte with hybrid fibroblastic-chondrogenic characteristics found in fibrocartilage, particularly in the avascular inner zone and transitional middle zone of the meniscus. In humans, fibrochondrocytes are marked by predominant expression of type I collagen (COL1A1) and fibril-associated collagens (COL3A1, COL6A1), while retaining type II collagen (COL2A1) expression and exhibiting lower SOX9 than hyaline chondrocytes. This molecular profile underlies the synthesis of abundant type I collagen essential for fibrocartilage matrix and reflects an intermediate phenotype between fibroblast and chondrocyte.
http://purl.obolibrary.org/obo/CL_0020021	fibrochondrocyte progenitor cell	http://purl.obolibrary.org/obo/CL_0008019	mesenchymal cell		A mesenchymal progenitor cell located in fibrocartilaginous tissues, along the fibrochondrocytic differentiation pathway that co-expresses both fibrochondrocyte markers (COL1A1, COL3A1) and mesenchymal stem cell markers (MCAM/CD146, MYLK) in humans. This cell serves as a progenitor for mature fibrochondrocytes and other meniscal cell types, with differentiation regulated by TGF-β signaling, focal adhesion, and extracellular matrix-receptor interaction pathways.
http://purl.obolibrary.org/obo/HP_6001438	Tenosynovitis	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		Inflammation of the synovial sheath that surrounds a tendon.
http://purl.obolibrary.org/obo/HP_0020308	Increased anteroposterior lens thickness	http://purl.obolibrary.org/obo/HP_0011526	Abnormality of lens shape		Increase in the anteroposterior (axial) dimension of the crystalline lens relative to the overall length of the globe.
http://purl.obolibrary.org/obo/HP_0020309	Ankle instability	http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology		Failure of ligamentous and muscular structures of the ankle to maintain normal joint alignment during movement, resulting in excessive motion that causes manifestations such as subjective or objective feeling of clunking/clicking in the ankle with movement, ankle 'giving way' or sensation of ankle dislocating.
http://purl.obolibrary.org/obo/HP_0020310	Retinal phlebitis	http://purl.obolibrary.org/obo/HP_0025188	Retinal vasculitis		Inflammation of retinal venules as manifested by perivascular sheathing or cuffing, vascular leakage and/or occlusion.
http://purl.obolibrary.org/obo/HP_0020311	Ophthalmic artery hypoperfusion	http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology		Chronic hypoperfusion due to large vessel disease e.g. carotid artery stenosis, Takayasu disease. Typically presents dilated veins, low retinal arterial pressure, peripheral microaneurysms, ocular hypotension and may lead to iris neovascularisation. Patients may have postural hypotension.
http://purl.obolibrary.org/obo/HP_0020312	Focal hyperpigmented area associated with subretinal scar tissue	http://purl.obolibrary.org/obo/HP_0011512	Fundus hyperpigmentation		Localized hyperpigmented areas, in the context of subretinal scar tissue, as seen after subretinal neovascularisation.
http://purl.obolibrary.org/obo/HP_0020313	Discrete fundus hypopigmentation	http://purl.obolibrary.org/obo/HP_0007894	Fundus hypopigmentation		Well-demarcated areas of the fundus, with relative reduction in pigment, with respect to the rest of the fundus.
http://purl.obolibrary.org/obo/HP_6001435	Abnormal medial epicondyle morphology	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		A structural anomaly of the medial epicondyle, which is the site of the attachment of various muscles, including the radial and ulnar flexor of the wrist, the superficial flexor of the fingers, the palmaris longus and the pronator teres muscle.
http://purl.obolibrary.org/obo/HP_6001434	Positive bursa fluid gram stain	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Demonstration of the presence of bacteria by gram staining of bursa fluid. The sample is generally obtained by bursal fluid aspiration.
http://purl.obolibrary.org/obo/HP_6001436	Medial humerus epicondyle avulsion fracture	http://purl.obolibrary.org/obo/HP_6001435	Abnormal medial epicondyle morphology		An avulsion fracture of the medial epicondyle of the elbow. Radiological examination in the anteroposterior and lateral projection can be used to make the diagnosis and to determine the degree and direction of the fracture displacement.
http://purl.obolibrary.org/obo/HP_6001437	Hand mass	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		A swelling or enlargement localized to the hand. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6001439	Tigroid fundus	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Enhanced visibility of large choroidal vessels through the retinal pigment epithelium (RPE). This reticulated pattern is commonly observed on fundus examination and color fundus photography. Such hypopigmented areas alternate with hyperpigmented zones in a tigroid pattern. Fundus tessellation is often associated with myopia and choroidal thinning.
http://purl.obolibrary.org/obo/HP_6001440	Decreased myocardial glycogen content	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		The amount of glycogen in the myocardial tissue of the heart is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001441	CSF anti-myelin oligodendrocyte glycoprotein antibody positivity	http://purl.obolibrary.org/obo/HP_0032265	CSF autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the cerebrospinal fluid (CSF) that react against myelin oligodendrocyte glycoprotein.
http://purl.obolibrary.org/obo/HP_6001442	Spinal cord H sign	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		The H sign can be ascertained by spinal magnetic resonance imaging (MRI) and represents spinal cord myelitis isolated to the gray matter. A longitudinally extensive T2 hyperintense spinal cord lesion from C6 to T10, predominantly involving the gray matter. The appearance of the anomaly is said to resemble the letter H.
http://purl.obolibrary.org/obo/HP_6001443	Abnormal testosterone: estradiol ratio	http://purl.obolibrary.org/obo/HP_0033799	Abnormal circulating sex hormone concentration		Any deviation from the normal ratio of testosterone and estradiol (the primary sex steroids) to each other. The testosterone:estradiol ratio is derived from total testosterone in ng/dL and total estradiol in pg/mL, and expressed as T:E. Normal ranges are affected by sex, age, and other factors.
http://purl.obolibrary.org/obo/HP_6001444	Abnormal circulating insulin-like growth factor 3 concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		The concentration of IGFBP-3 (Insulin-like Growth Factor-Binding Protein 3) in the blood circulation is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_6001445	Decreased circulating insulin-like growth factor 3 concentration	http://purl.obolibrary.org/obo/HP_6001444	Abnormal circulating insulin-like growth factor 3 concentration		The concentration of insulin-like growth factor 3 concentration (IGF3) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001446	Airway chondritis	http://purl.obolibrary.org/obo/HP_0100662	Chondritis		Inflammation of the cartilage of the airway, including especially the trachea and bronchi.
http://purl.obolibrary.org/obo/HP_6001447	Costochondritis	http://purl.obolibrary.org/obo/HP_0100662	Chondritis		inflammation of the costal cartilage (the cartilage that connects the ribs to the sternum). The typical presentation of costochondritis is bilateral parasternal chest wall pain exacerbated by deep breaths, coughing, and stretching. The upper (predominantly second through fifth) costochondral and/or costosternal junctions are most commonly involved. The areas of tenderness are not generally accompanied by heat, erythema, or localized swelling.
http://purl.obolibrary.org/obo/HP_6001448	History of ocular surgery	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		Past medical history of surgical procedure on the eye or its surroundings.
http://purl.obolibrary.org/obo/HP_6001449	Increased plantar fascia thickness	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		Increased thickness of the plantar fascia. This finding can be ascertained by ultrasound or magnetic resonance imaging.
http://purl.obolibrary.org/obo/HP_6001450	Increased mixed venous oxygen saturation	http://purl.obolibrary.org/obo/HP_6001379	Abnormal mixed venous oxygen saturation		Oxygen saturation in mixed venous blood (SvO2), as measured in a sample of mixed venous blood drawn from the distal lumen of a catheter placed in the pulmonary artery, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001451	Decreased mixed venous oxygen saturation	http://purl.obolibrary.org/obo/HP_6001379	Abnormal mixed venous oxygen saturation		Oxygen saturation in mixed venous blood (SvO2), as measured in a sample of mixed venous blood drawn from the distal lumen of a catheter placed in the pulmonary artery, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001452	Chocolate brown blood	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		Characteristic chocolate-brown color of circulating blood with an elevated methemoglobin content.
http://purl.obolibrary.org/obo/HP_6001453	Elevated pCO2 gap	http://purl.obolibrary.org/obo/HP_0500164	Abnormal blood carbon dioxide level		The difference between the venous-to-arterial carbon dioxide saturation (Pv-aCO2) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001454	Putaminal eye sign	http://purl.obolibrary.org/obo/HP_0031982	Abnormal putamen morphology		An imaging anomly of the putamen that is thought to be pathognomic for MEGDEL syndrome (3-MethylGlutaconic aciduria, Deafness, Encephalopathy, Leigh-like syndrome MIM #614739). In stage 1 of the disease, T2 signal changes of the pallidum are present. In stage 2, swelling of the putamen and caudate nucleus is seen. The dorsal putamen contains an eye that shows no signal alteration and (thus) seems to be spared during this stage of the disease. It later increases, reflecting progressive putaminal involvement. Sparing of the mid dorsal putamen (showing normal signal surrounded by T2 hyperintense signal) is referred to as the putaminal eye.
http://purl.obolibrary.org/obo/HP_6001455	Decreased coracohumeral distance	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		Axial view on shoulder X-ray or MRI showing decreased distance between posterior border of the coracoid process and anterior border of the humeral head of less than 6 mm; subcoracoid impingement; decreased coracohumeral interval.
http://purl.obolibrary.org/obo/HP_6001456	Abnormal deltoid muscle morphology	http://purl.obolibrary.org/obo/HP_0001435	Abnormality of the shoulder girdle musculature		Any structural anomaly of the deltoid muscle, the large triangular intrinsic shoulder muscle, so named because its shape resembles the inverted Greek letter delta.
http://purl.obolibrary.org/obo/HP_6001457	Deltoid muscle tear	http://purl.obolibrary.org/obo/HP_0001435	Abnormality of the shoulder girdle musculature		An injury of the deltoid muscle of the shoulder or its tendon characterized by partial or complete rupture.
http://purl.obolibrary.org/obo/HP_6001458	Glenohumeral arthritis	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		Anteropostrior (AP), axillary, or Grashey (true AP) view X-ray of the shoulder showing radiographic evidence of osteoarthritis such as joint space narrowing, subchondral sclerosis, subchondral cysts, and/or osteophyte formation in the glenohumeral joint.
http://purl.obolibrary.org/obo/HP_0020314	Macular pseudohole	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		A macular pseudohole is a partial-thickness gap in a normal-thickness fovea, located in the center of the macula.
http://purl.obolibrary.org/obo/HP_0020315	Lamellar macular hole	http://purl.obolibrary.org/obo/HP_0001103	Abnormal macular morphology		A lamellar macular hole is a structural abnormality of the macula, characterized by a partial-thickness gap in a thinner fovea, located in the center of the macula.
http://purl.obolibrary.org/obo/HP_0020316	Middle cerebral artery berry aneurysm	http://purl.obolibrary.org/obo/HP_0007029	Cerebral berry aneurysm		A small, sac-like aneurysm (outpouching) of the middle cerebral artery (MCA). MCA berry aneurysms may occur at the MCA bifurcation, on the anterior communicant artery, the anterior cerebral artery, the internal carotid artery, or on the posterior communicant artery.
http://purl.obolibrary.org/obo/HP_6001459	Dental root fusion	http://purl.obolibrary.org/obo/HP_0006486	Abnormal dental root morphology		An anomaly of the roots of a multi-rooted tooth (such as a molar) in which the roots are not physically divided by bone or periodontal ligament space.
http://purl.obolibrary.org/obo/HP_6001460	Difficulty floating in water	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A phenomenon whereby an individual struggles to float, cannot swim despite adequate training, or simply sinks. This phenomenon may be observed in individuals with conditions such as osteopetrosis that are characterized by substantially increased bone mineral density (which implies reduced bouyancy).
http://purl.obolibrary.org/obo/HP_6001461	Aortitis	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Aortitis refers to inflammatory changes to the wall of the aorta and incorporates both infectious and non-infectious etiologies.
http://purl.obolibrary.org/obo/HP_6001462	Upper extremity claudication	http://purl.obolibrary.org/obo/HP_0004417	Intermittent claudication		Pain in an arm that is triggered by muscular exertion.
http://purl.obolibrary.org/obo/HP_6001463	Tongue claudication	http://purl.obolibrary.org/obo/HP_0004417	Intermittent claudication		Pain in the tongue induced by speaking or chewing.
http://purl.obolibrary.org/obo/HP_6001464	Cerebral perivascular enhancement pattern	http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology		Focal, regional or diffuse magnetic resonance imaging (MRI) enhancement of intracranial perivascular spaces (PVS). This enhancement pattern is recognizable by its topography that follows PVS distribution, particularly identifiable in regions where PVS predominate (centra semiovalia, basal ganglia and the brachium pontis)15 although it can be found throughout the whole brain. Depending on the perpendicular or parallel orientation of MRI sections to the long axis of PVS, enhanced PVS appear as dots or curvilinear elements respectively. Depending on the causal pathology, PVE may appear more linear or nodular.
http://purl.obolibrary.org/obo/HP_6001465	Long head of biceps tendon dislocation	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		Dislocation or subluxation of the long head of the biceps tendon out of the bicipital groove (as documented by magnetic resonance imaging of the shoulder) or dynamic ultrasound of the shoulder showing subluxation or dislocation of the long head of the biceps tendon out of the bicipital groove.
http://purl.obolibrary.org/obo/CL_0020059	serous demilune cell of salivary gland	http://purl.obolibrary.org/obo/CL_0000313	serous secreting cell		A serous secreting cell that is part of a salivary gland, forming crescent-shaped (demilune) caps at the distal ends of mucous acini in mixed glands. Prominent in human submandibular and sublingual glands, this cell delivers its watery, enzyme-rich secretions including alpha-amylase through intercellular canaliculi that run between adjacent mucous cells to reach the acinar lumen (Amano et al., 2012). In rodents, these cells also express neuronal nitric oxide synthase (nNOS).
http://purl.obolibrary.org/obo/GO_0000016	lactase activity	http://purl.obolibrary.org/obo/GO_0004553	hydrolase activity, hydrolyzing O-glycosyl compounds		Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.
http://purl.obolibrary.org/obo/GO_0000018	regulation of DNA recombination	http://purl.obolibrary.org/obo/GO_0051052	regulation of DNA metabolic process		Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.
http://purl.obolibrary.org/obo/GO_0000048	peptidyltransferase activity	http://purl.obolibrary.org/obo/GO_0140101	catalytic activity, acting on a tRNA		Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.
http://purl.obolibrary.org/obo/GO_0000070	mitotic sister chromatid segregation	http://purl.obolibrary.org/obo/GO_1903047	mitotic cell cycle process		The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
http://purl.obolibrary.org/obo/GO_0000096	sulfur amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0006790	sulfur compound metabolic process		The chemical reactions and pathways involving amino acids containing sulfur.
http://purl.obolibrary.org/obo/GO_0000226	microtubule cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0007017	microtubule-based process		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
http://purl.obolibrary.org/obo/GO_0000228	nuclear chromosome	http://purl.obolibrary.org/obo/GO_0005694	chromosome		A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
http://purl.obolibrary.org/obo/GO_0000262	mitochondrial chromosome	http://purl.obolibrary.org/obo/GO_0005694	chromosome		A chromosome found in the mitochondrion of a eukaryotic cell.
http://purl.obolibrary.org/obo/GO_0000271	polysaccharide biosynthetic process	http://purl.obolibrary.org/obo/GO_0016051	carbohydrate biosynthetic process		The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
http://purl.obolibrary.org/obo/GO_0000272	polysaccharide catabolic process	http://purl.obolibrary.org/obo/GO_0016052	carbohydrate catabolic process		The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
http://purl.obolibrary.org/obo/GO_0000278	mitotic cell cycle	http://purl.obolibrary.org/obo/GO_0007049	cell cycle		Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
http://purl.obolibrary.org/obo/GO_0000280	nuclear division	http://purl.obolibrary.org/obo/GO_0048285	organelle fission		The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
http://purl.obolibrary.org/obo/GO_0000313	organellar ribosome	http://purl.obolibrary.org/obo/GO_0005840	ribosome		A ribosome contained within a subcellular membrane-bounded organelle.
http://purl.obolibrary.org/obo/GO_0000323	lytic vacuole	http://purl.obolibrary.org/obo/GO_0005773	vacuole		A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.
http://purl.obolibrary.org/obo/GO_0000768	syncytium formation by cell-cell fusion	http://purl.obolibrary.org/obo/GO_0140253	cell-cell fusion		The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
http://purl.obolibrary.org/obo/GO_0000785	chromatin	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
http://purl.obolibrary.org/obo/GO_0000791	euchromatin	http://purl.obolibrary.org/obo/GO_0000785	chromatin		A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.
http://purl.obolibrary.org/obo/GO_0000792	heterochromatin	http://purl.obolibrary.org/obo/GO_0000785	chromatin		A compact and highly condensed form of chromatin that is refractory to transcription.
http://purl.obolibrary.org/obo/GO_0000819	sister chromatid segregation	http://purl.obolibrary.org/obo/GO_0098813	nuclear chromosome segregation		The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.
http://purl.obolibrary.org/obo/GO_0000959	mitochondrial RNA metabolic process	http://purl.obolibrary.org/obo/GO_0016070	RNA metabolic process		The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.
http://purl.obolibrary.org/obo/GO_0001501	skeletal system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
http://purl.obolibrary.org/obo/GO_0001503	ossification	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
http://purl.obolibrary.org/obo/GO_0001508	action potential	http://purl.obolibrary.org/obo/GO_0042391	regulation of membrane potential		A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
http://purl.obolibrary.org/obo/GO_0001523	retinoid metabolic process	http://purl.obolibrary.org/obo/GO_0016101	diterpenoid metabolic process		The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.
http://purl.obolibrary.org/obo/GO_0001525	angiogenesis	http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis		Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
http://purl.obolibrary.org/obo/GO_0001539	cilium or flagellum-dependent cell motility	http://purl.obolibrary.org/obo/GO_0048870	cell motility		Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.
http://purl.obolibrary.org/obo/GO_0001558	regulation of cell growth	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate, extent or direction of cell growth.
http://purl.obolibrary.org/obo/GO_0001560	regulation of cell growth by extracellular stimulus	http://purl.obolibrary.org/obo/GO_0001558	regulation of cell growth		Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.
http://purl.obolibrary.org/obo/GO_0001568	blood vessel development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
http://purl.obolibrary.org/obo/GO_0001569	branching involved in blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_0048754	branching morphogenesis of an epithelial tube		The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
http://purl.obolibrary.org/obo/GO_0001573	ganglioside metabolic process	http://purl.obolibrary.org/obo/GO_0006687	glycosphingolipid metabolic process		The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.
http://purl.obolibrary.org/obo/GO_0001578	microtubule bundle formation	http://purl.obolibrary.org/obo/GO_0000226	microtubule cytoskeleton organization		A process that results in a parallel arrangement of microtubules.
http://purl.obolibrary.org/obo/GO_0001659	temperature homeostasis	http://purl.obolibrary.org/obo/GO_0048871	multicellular organismal-level homeostasis		A homeostatic process in which an organism modulates its internal body temperature.
http://purl.obolibrary.org/obo/GO_0001666	response to hypoxia	http://purl.obolibrary.org/obo/GO_0036293	response to decreased oxygen levels		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
http://purl.obolibrary.org/obo/GO_0001667	ameboidal-type cell migration	http://purl.obolibrary.org/obo/GO_0016477	cell migration		Cell migration that is accomplished by extension and retraction of a pseudopodium.
http://purl.obolibrary.org/obo/GO_0001675	acrosome assembly	http://purl.obolibrary.org/obo/GO_0070925	organelle assembly		The formation of the acrosome from the spermatid Golgi.
http://purl.obolibrary.org/obo/GO_0001677	formation of translation initiation ternary complex	http://purl.obolibrary.org/obo/GO_0022618	protein-RNA complex assembly		Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).
http://purl.obolibrary.org/obo/GO_0001696	gastric acid secretion	http://purl.obolibrary.org/obo/GO_0046717	acid secretion		The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
http://purl.obolibrary.org/obo/GO_0001701	in utero embryonic development	http://purl.obolibrary.org/obo/GO_0043009	chordate embryonic development		The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
http://purl.obolibrary.org/obo/GO_0001704	formation of primary germ layer	http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis		The formation of the ectoderm, mesoderm and endoderm during gastrulation.
http://purl.obolibrary.org/obo/GO_0001705	ectoderm formation	http://purl.obolibrary.org/obo/GO_0001704	formation of primary germ layer		The formation of ectoderm during gastrulation.
http://purl.obolibrary.org/obo/GO_0001706	endoderm formation	http://purl.obolibrary.org/obo/GO_0001704	formation of primary germ layer		The formation of the endoderm during gastrulation.
http://purl.obolibrary.org/obo/GO_0001707	mesoderm formation	http://purl.obolibrary.org/obo/GO_0001704	formation of primary germ layer		The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
http://purl.obolibrary.org/obo/GO_0001763	morphogenesis of a branching structure	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.
http://purl.obolibrary.org/obo/GO_0001764	neuron migration	http://purl.obolibrary.org/obo/GO_0016477	cell migration		The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
http://purl.obolibrary.org/obo/GO_0001773	myeloid dendritic cell activation	http://purl.obolibrary.org/obo/GO_0002274	myeloid leukocyte activation		The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
http://purl.obolibrary.org/obo/GO_0001775	cell activation	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.
http://purl.obolibrary.org/obo/GO_0001816	cytokine production	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0001817	regulation of cytokine production	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate, or extent of production of a cytokine.
http://purl.obolibrary.org/obo/GO_0001818	negative regulation of cytokine production	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the rate of production of a cytokine.
http://purl.obolibrary.org/obo/GO_0001819	positive regulation of cytokine production	http://purl.obolibrary.org/obo/GO_0010628	positive regulation of gene expression		Any process that activates or increases the frequency, rate or extent of production of a cytokine.
http://purl.obolibrary.org/obo/GO_0001820	serotonin secretion	http://purl.obolibrary.org/obo/GO_0023061	signal release		The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.
http://purl.obolibrary.org/obo/GO_0001821	histamine secretion	http://purl.obolibrary.org/obo/GO_0051608	histamine transport		The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.
http://purl.obolibrary.org/obo/GO_0001838	embryonic epithelial tube formation	http://purl.obolibrary.org/obo/GO_0072175	epithelial tube formation		The morphogenesis of an embryonic epithelium into a tube-shaped structure.
http://purl.obolibrary.org/obo/GO_0001841	neural tube formation	http://purl.obolibrary.org/obo/GO_0001838	embryonic epithelial tube formation		The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
http://purl.obolibrary.org/obo/GO_0001843	neural tube closure	http://purl.obolibrary.org/obo/GO_0060606	tube closure		The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
http://purl.obolibrary.org/obo/GO_0001890	placenta development	http://purl.obolibrary.org/obo/GO_0048513	animal organ development		The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
http://purl.obolibrary.org/obo/GO_0001893	maternal placenta development	http://purl.obolibrary.org/obo/GO_0060135	maternal process involved in female pregnancy		Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
http://purl.obolibrary.org/obo/GO_0001894	tissue homeostasis	http://purl.obolibrary.org/obo/GO_0060249	anatomical structure homeostasis		A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
http://purl.obolibrary.org/obo/GO_0001906	cell killing	http://purl.obolibrary.org/obo/GO_0009987	cellular process		Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
http://purl.obolibrary.org/obo/GO_0001909	leukocyte mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0002443	leukocyte mediated immunity		The directed killing of a target cell by a leukocyte.
http://purl.obolibrary.org/obo/GO_0001910	regulation of leukocyte mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0031341	regulation of cell killing		Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
http://purl.obolibrary.org/obo/GO_0001911	negative regulation of leukocyte mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0031342	negative regulation of cell killing		Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
http://purl.obolibrary.org/obo/GO_0001912	positive regulation of leukocyte mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0031343	positive regulation of cell killing		Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.
http://purl.obolibrary.org/obo/GO_0001944	vasculature development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
http://purl.obolibrary.org/obo/GO_0001956	positive regulation of neurotransmitter secretion	http://purl.obolibrary.org/obo/GO_1903532	positive regulation of secretion by cell		Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
http://purl.obolibrary.org/obo/GO_0001957	intramembranous ossification	http://purl.obolibrary.org/obo/GO_0036072	direct ossification		Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.
http://purl.obolibrary.org/obo/GO_0001958	endochondral ossification	http://purl.obolibrary.org/obo/GO_0036075	replacement ossification		Replacement ossification wherein bone tissue replaces cartilage.
http://purl.obolibrary.org/obo/GO_0001959	regulation of cytokine-mediated signaling pathway	http://purl.obolibrary.org/obo/GO_0060759	regulation of response to cytokine stimulus		Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.
http://purl.obolibrary.org/obo/GO_0001960	negative regulation of cytokine-mediated signaling pathway	http://purl.obolibrary.org/obo/GO_0060761	negative regulation of response to cytokine stimulus		Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
http://purl.obolibrary.org/obo/GO_0001961	positive regulation of cytokine-mediated signaling pathway	http://purl.obolibrary.org/obo/GO_0060760	positive regulation of response to cytokine stimulus		Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
http://purl.obolibrary.org/obo/GO_0001964	startle response	http://purl.obolibrary.org/obo/GO_0050905	neuromuscular process		An action or movement due to the application of a sudden unexpected stimulus.
http://purl.obolibrary.org/obo/GO_0001976	nervous system process involved in regulation of systemic arterial blood pressure	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		The regulation of blood pressure mediated by detection of stimuli and a neurological response.
http://purl.obolibrary.org/obo/GO_0001990	regulation of systemic arterial blood pressure by hormone	http://purl.obolibrary.org/obo/GO_0050886	endocrine process		The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
http://purl.obolibrary.org/obo/GO_0001992	regulation of systemic arterial blood pressure by vasopressin	http://purl.obolibrary.org/obo/GO_0001990	regulation of systemic arterial blood pressure by hormone		The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.
http://purl.obolibrary.org/obo/GO_0002009	morphogenesis of an epithelium	http://purl.obolibrary.org/obo/GO_0048729	tissue morphogenesis		The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
http://purl.obolibrary.org/obo/GO_0002016	regulation of blood volume by renin-angiotensin	http://purl.obolibrary.org/obo/GO_0003081	regulation of systemic arterial blood pressure by renin-angiotensin		The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.
http://purl.obolibrary.org/obo/GO_0002018	renin-angiotensin regulation of aldosterone production	http://purl.obolibrary.org/obo/GO_2000858	regulation of aldosterone secretion		The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.
http://purl.obolibrary.org/obo/GO_0002027	regulation of heart rate	http://purl.obolibrary.org/obo/GO_0065008	regulation of biological quality		Any process that modulates the frequency or rate of heart contraction.
http://purl.obolibrary.org/obo/GO_0002053	positive regulation of mesenchymal cell proliferation	http://purl.obolibrary.org/obo/GO_0010464	regulation of mesenchymal cell proliferation		The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.
http://purl.obolibrary.org/obo/GO_0002065	columnar/cuboidal epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0030855	epithelial cell differentiation		The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
http://purl.obolibrary.org/obo/GO_0002087	regulation of respiratory gaseous exchange by nervous system process	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.
http://purl.obolibrary.org/obo/GO_0002185	creatine kinase complex	http://purl.obolibrary.org/obo/GO_0061695	transferase complex, transferring phosphorus-containing groups		A protein complex having creatine kinase activity.
http://purl.obolibrary.org/obo/GO_0002187	mitochondrial creatine kinase complex	http://purl.obolibrary.org/obo/GO_0002185	creatine kinase complex		An octomeric protein complex having creatine kinase activity.
http://purl.obolibrary.org/obo/GO_0002200	somatic diversification of immune receptors	http://purl.obolibrary.org/obo/GO_0002376	immune system process		The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.
http://purl.obolibrary.org/obo/GO_0002204	somatic recombination of immunoglobulin genes involved in immune response	http://purl.obolibrary.org/obo/GO_0016447	somatic recombination of immunoglobulin gene segments		The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.
http://purl.obolibrary.org/obo/GO_0002208	somatic diversification of immunoglobulins involved in immune response	http://purl.obolibrary.org/obo/GO_0016445	somatic diversification of immunoglobulins		The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response.
http://purl.obolibrary.org/obo/GO_0002225	positive regulation of antimicrobial peptide production	http://purl.obolibrary.org/obo/GO_0002784	regulation of antimicrobial peptide production		Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.
http://purl.obolibrary.org/obo/GO_0002228	natural killer cell mediated immunity	http://purl.obolibrary.org/obo/GO_0045087	innate immune response		The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.
http://purl.obolibrary.org/obo/GO_0002232	leukocyte chemotaxis involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0030595	leukocyte chemotaxis		The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
http://purl.obolibrary.org/obo/GO_0002233	leukocyte chemotaxis involved in immune response	http://purl.obolibrary.org/obo/GO_0030595	leukocyte chemotaxis		The movement of an immune cell in response to an external stimulus a part of an immune response.
http://purl.obolibrary.org/obo/GO_0002244	hematopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_0030154	cell differentiation		The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
http://purl.obolibrary.org/obo/GO_0002246	wound healing involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0042060	wound healing		The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.
http://purl.obolibrary.org/obo/GO_0002250	adaptive immune response	http://purl.obolibrary.org/obo/GO_0006955	immune response		An immune response mediated by cells expressing specific receptors for antigens produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
http://purl.obolibrary.org/obo/GO_0002251	organ or tissue specific immune response	http://purl.obolibrary.org/obo/GO_0006955	immune response		An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.
http://purl.obolibrary.org/obo/GO_0002252	immune effector process	http://purl.obolibrary.org/obo/GO_0002376	immune system process		Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.
http://purl.obolibrary.org/obo/GO_0002253	activation of immune response	http://purl.obolibrary.org/obo/GO_0050778	positive regulation of immune response		Any process that initiates an immune response.
http://purl.obolibrary.org/obo/GO_0002262	myeloid cell homeostasis	http://purl.obolibrary.org/obo/GO_0048872	homeostasis of number of cells		The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
http://purl.obolibrary.org/obo/GO_0002263	cell activation involved in immune response	http://purl.obolibrary.org/obo/GO_0002252	immune effector process		A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
http://purl.obolibrary.org/obo/GO_0002269	leukocyte activation involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0045321	leukocyte activation		A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.
http://purl.obolibrary.org/obo/GO_0002274	myeloid leukocyte activation	http://purl.obolibrary.org/obo/GO_0045321	leukocyte activation		A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.
http://purl.obolibrary.org/obo/GO_0002275	myeloid cell activation involved in immune response	http://purl.obolibrary.org/obo/GO_0002366	leukocyte activation involved in immune response		A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.
http://purl.obolibrary.org/obo/GO_0002277	myeloid dendritic cell activation involved in immune response	http://purl.obolibrary.org/obo/GO_0002275	myeloid cell activation involved in immune response		The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
http://purl.obolibrary.org/obo/GO_0002285	lymphocyte activation involved in immune response	http://purl.obolibrary.org/obo/GO_0046649	lymphocyte activation		A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
http://purl.obolibrary.org/obo/GO_0002286	T cell activation involved in immune response	http://purl.obolibrary.org/obo/GO_0042110	T cell activation		The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.
http://purl.obolibrary.org/obo/GO_0002292	T cell differentiation involved in immune response	http://purl.obolibrary.org/obo/GO_0030217	T cell differentiation		The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.
http://purl.obolibrary.org/obo/GO_0002309	T cell proliferation involved in immune response	http://purl.obolibrary.org/obo/GO_0042098	T cell proliferation		The expansion of a T cell population by cell division as part of an immune response.
http://purl.obolibrary.org/obo/GO_0002312	B cell activation involved in immune response	http://purl.obolibrary.org/obo/GO_0042113	B cell activation		The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
http://purl.obolibrary.org/obo/GO_0002313	mature B cell differentiation involved in immune response	http://purl.obolibrary.org/obo/GO_0002335	mature B cell differentiation		The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.
http://purl.obolibrary.org/obo/GO_0002319	memory B cell differentiation	http://purl.obolibrary.org/obo/GO_0090715	immunological memory formation process		The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.
http://purl.obolibrary.org/obo/GO_0002322	B cell proliferation involved in immune response	http://purl.obolibrary.org/obo/GO_0042100	B cell proliferation		The expansion of a B cell population by cell division following B cell activation during an immune response.
http://purl.obolibrary.org/obo/GO_0002335	mature B cell differentiation	http://purl.obolibrary.org/obo/GO_0030183	B cell differentiation		The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.
http://purl.obolibrary.org/obo/GO_0002339	B cell selection	http://purl.obolibrary.org/obo/GO_0002376	immune system process		The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.
http://purl.obolibrary.org/obo/GO_0002343	peripheral B cell selection	http://purl.obolibrary.org/obo/GO_0002339	B cell selection		Any B cell selection process that occurs in the periphery.
http://purl.obolibrary.org/obo/GO_0002344	B cell affinity maturation	http://purl.obolibrary.org/obo/GO_0002343	peripheral B cell selection		The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.
http://purl.obolibrary.org/obo/GO_0002349	histamine production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0002532	production of molecular mediator involved in inflammatory response		The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002351	serotonin production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0002532	production of molecular mediator involved in inflammatory response		The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002366	leukocyte activation involved in immune response	http://purl.obolibrary.org/obo/GO_0045321	leukocyte activation		A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
http://purl.obolibrary.org/obo/GO_0002367	cytokine production involved in immune response	http://purl.obolibrary.org/obo/GO_0002440	production of molecular mediator of immune response		The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002376	immune system process	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
http://purl.obolibrary.org/obo/GO_0002377	immunoglobulin production	http://purl.obolibrary.org/obo/GO_0002440	production of molecular mediator of immune response		The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	http://purl.obolibrary.org/obo/GO_0002377	immunoglobulin production		The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002384	hepatic immune response	http://purl.obolibrary.org/obo/GO_0002251	organ or tissue specific immune response		An immune response taking place in the liver.
http://purl.obolibrary.org/obo/GO_0002440	production of molecular mediator of immune response	http://purl.obolibrary.org/obo/GO_0010467	gene expression		The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002441	histamine secretion involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0046879	hormone secretion		The regulated release of histamine by a cell as part of an inflammatory response.
http://purl.obolibrary.org/obo/GO_0002442	serotonin secretion involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0001820	serotonin secretion		The regulated release of serotonin by a cell as part of an inflammatory response.
http://purl.obolibrary.org/obo/GO_0002443	leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002252	immune effector process		Any process involved in the carrying out of an immune response by a leukocyte.
http://purl.obolibrary.org/obo/GO_0002444	myeloid leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002443	leukocyte mediated immunity		Any process involved in the carrying out of an immune response by a myeloid leukocyte.
http://purl.obolibrary.org/obo/GO_0002446	neutrophil mediated immunity	http://purl.obolibrary.org/obo/GO_0002444	myeloid leukocyte mediated immunity		Any process involved in the carrying out of an immune response by a neutrophil.
http://purl.obolibrary.org/obo/GO_0002449	lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002443	leukocyte mediated immunity		Any process involved in the carrying out of an immune response by a lymphocyte.
http://purl.obolibrary.org/obo/GO_0002456	T cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process involved in the carrying out of an immune response by a T cell.
http://purl.obolibrary.org/obo/GO_0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	http://purl.obolibrary.org/obo/GO_0002250	adaptive immune response		An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.
http://purl.obolibrary.org/obo/GO_0002461	tolerance induction dependent upon immune response	http://purl.obolibrary.org/obo/GO_0002507	tolerance induction		Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.
http://purl.obolibrary.org/obo/GO_0002465	peripheral tolerance induction	http://purl.obolibrary.org/obo/GO_0002461	tolerance induction dependent upon immune response		Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
http://purl.obolibrary.org/obo/GO_0002467	germinal center formation	http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis		The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.
http://purl.obolibrary.org/obo/GO_0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	http://purl.obolibrary.org/obo/GO_0019882	antigen processing and presentation		The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.
http://purl.obolibrary.org/obo/GO_0002507	tolerance induction	http://purl.obolibrary.org/obo/GO_0002376	immune system process		A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.
http://purl.obolibrary.org/obo/GO_0002520	immune system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
http://purl.obolibrary.org/obo/GO_0002521	leukocyte differentiation	http://purl.obolibrary.org/obo/GO_0030154	cell differentiation		The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
http://purl.obolibrary.org/obo/GO_0002522	leukocyte migration involved in immune response	http://purl.obolibrary.org/obo/GO_0050900	leukocyte migration		The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.
http://purl.obolibrary.org/obo/GO_0002523	leukocyte migration involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0050900	leukocyte migration		The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.
http://purl.obolibrary.org/obo/GO_0002526	acute inflammatory response	http://purl.obolibrary.org/obo/GO_0006954	inflammatory response		Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
http://purl.obolibrary.org/obo/GO_0002532	production of molecular mediator involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002534	cytokine production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0002532	production of molecular mediator involved in inflammatory response		The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002536	respiratory burst involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0002679	respiratory burst involved in defense response		A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002538	arachidonate metabolite production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0002532	production of molecular mediator involved in inflammatory response		The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002539	prostaglandin production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0002538	arachidonate metabolite production involved in inflammatory response		The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.
http://purl.obolibrary.org/obo/GO_0002544	chronic inflammatory response	http://purl.obolibrary.org/obo/GO_0006954	inflammatory response		Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.
http://purl.obolibrary.org/obo/GO_0002548	monocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0097529	myeloid leukocyte migration		The movement of a monocyte in response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0002562	somatic diversification of immune receptors via germline recombination within a single locus	http://purl.obolibrary.org/obo/GO_0016444	somatic cell DNA recombination		The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.
http://purl.obolibrary.org/obo/GO_0002566	somatic diversification of immune receptors via somatic mutation	http://purl.obolibrary.org/obo/GO_0002200	somatic diversification of immune receptors		The process in which immune receptor genes are diversified through somatic mutation.
http://purl.obolibrary.org/obo/GO_0002573	myeloid leukocyte differentiation	http://purl.obolibrary.org/obo/GO_0030099	myeloid cell differentiation		The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
http://purl.obolibrary.org/obo/GO_0002574	thrombocyte differentiation	http://purl.obolibrary.org/obo/GO_0030099	myeloid cell differentiation		The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
http://purl.obolibrary.org/obo/GO_0002577	regulation of antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002682	regulation of immune system process		Any process that modulates the frequency, rate, or extent of antigen processing and presentation.
http://purl.obolibrary.org/obo/GO_0002578	negative regulation of antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002683	negative regulation of immune system process		Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.
http://purl.obolibrary.org/obo/GO_0002579	positive regulation of antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002684	positive regulation of immune system process		Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.
http://purl.obolibrary.org/obo/GO_0002580	regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	http://purl.obolibrary.org/obo/GO_0002577	regulation of antigen processing and presentation		Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
http://purl.obolibrary.org/obo/GO_0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	http://purl.obolibrary.org/obo/GO_0002580	regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II		Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
http://purl.obolibrary.org/obo/GO_0002582	positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	http://purl.obolibrary.org/obo/GO_0002580	regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II		Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.
http://purl.obolibrary.org/obo/GO_0002634	regulation of germinal center formation	http://purl.obolibrary.org/obo/GO_0022603	regulation of anatomical structure morphogenesis		Any process that modulates the frequency, rate, or extent of germinal center formation.
http://purl.obolibrary.org/obo/GO_0002635	negative regulation of germinal center formation	http://purl.obolibrary.org/obo/GO_0051093	negative regulation of developmental process		Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation.
http://purl.obolibrary.org/obo/GO_0002636	positive regulation of germinal center formation	http://purl.obolibrary.org/obo/GO_0051094	positive regulation of developmental process		Any process that activates or increases the frequency, rate, or extent of germinal center formation.
http://purl.obolibrary.org/obo/GO_0002637	regulation of immunoglobulin production	http://purl.obolibrary.org/obo/GO_0002700	regulation of production of molecular mediator of immune response		Any process that modulates the frequency, rate, or extent of immunoglobulin production.
http://purl.obolibrary.org/obo/GO_0002638	negative regulation of immunoglobulin production	http://purl.obolibrary.org/obo/GO_0002701	negative regulation of production of molecular mediator of immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.
http://purl.obolibrary.org/obo/GO_0002639	positive regulation of immunoglobulin production	http://purl.obolibrary.org/obo/GO_0002702	positive regulation of production of molecular mediator of immune response		Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
http://purl.obolibrary.org/obo/GO_0002643	regulation of tolerance induction	http://purl.obolibrary.org/obo/GO_0002682	regulation of immune system process		Any process that modulates the frequency, rate, or extent of tolerance induction.
http://purl.obolibrary.org/obo/GO_0002644	negative regulation of tolerance induction	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.
http://purl.obolibrary.org/obo/GO_0002645	positive regulation of tolerance induction	http://purl.obolibrary.org/obo/GO_0051240	positive regulation of multicellular organismal process		Any process that activates or increases the frequency, rate, or extent of tolerance induction.
http://purl.obolibrary.org/obo/GO_0002652	regulation of tolerance induction dependent upon immune response	http://purl.obolibrary.org/obo/GO_0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.
http://purl.obolibrary.org/obo/GO_0002653	negative regulation of tolerance induction dependent upon immune response	http://purl.obolibrary.org/obo/GO_0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.
http://purl.obolibrary.org/obo/GO_0002654	positive regulation of tolerance induction dependent upon immune response	http://purl.obolibrary.org/obo/GO_0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response.
http://purl.obolibrary.org/obo/GO_0002658	regulation of peripheral tolerance induction	http://purl.obolibrary.org/obo/GO_0002652	regulation of tolerance induction dependent upon immune response		Any process that modulates the frequency, rate, or extent of peripheral tolerance induction.
http://purl.obolibrary.org/obo/GO_0002659	negative regulation of peripheral tolerance induction	http://purl.obolibrary.org/obo/GO_0002658	regulation of peripheral tolerance induction		Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction.
http://purl.obolibrary.org/obo/GO_0002660	positive regulation of peripheral tolerance induction	http://purl.obolibrary.org/obo/GO_0002658	regulation of peripheral tolerance induction		Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction.
http://purl.obolibrary.org/obo/GO_0002673	regulation of acute inflammatory response	http://purl.obolibrary.org/obo/GO_0050727	regulation of inflammatory response		Any process that modulates the frequency, rate, or extent of an acute inflammatory response.
http://purl.obolibrary.org/obo/GO_0002674	negative regulation of acute inflammatory response	http://purl.obolibrary.org/obo/GO_0050728	negative regulation of inflammatory response		Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.
http://purl.obolibrary.org/obo/GO_0002675	positive regulation of acute inflammatory response	http://purl.obolibrary.org/obo/GO_0050729	positive regulation of inflammatory response		Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.
http://purl.obolibrary.org/obo/GO_0002676	regulation of chronic inflammatory response	http://purl.obolibrary.org/obo/GO_0050727	regulation of inflammatory response		Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.
http://purl.obolibrary.org/obo/GO_0002677	negative regulation of chronic inflammatory response	http://purl.obolibrary.org/obo/GO_0050728	negative regulation of inflammatory response		Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.
http://purl.obolibrary.org/obo/GO_0002678	positive regulation of chronic inflammatory response	http://purl.obolibrary.org/obo/GO_0050729	positive regulation of inflammatory response		Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.
http://purl.obolibrary.org/obo/GO_0002679	respiratory burst involved in defense response	http://purl.obolibrary.org/obo/GO_0045730	respiratory burst		A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0002682	regulation of immune system process	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate, or extent of an immune system process.
http://purl.obolibrary.org/obo/GO_0002683	negative regulation of immune system process	http://purl.obolibrary.org/obo/GO_0048519	negative regulation of biological process		Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
http://purl.obolibrary.org/obo/GO_0002684	positive regulation of immune system process	http://purl.obolibrary.org/obo/GO_0048518	positive regulation of biological process		Any process that activates or increases the frequency, rate, or extent of an immune system process.
http://purl.obolibrary.org/obo/GO_0002685	regulation of leukocyte migration	http://purl.obolibrary.org/obo/GO_0030334	regulation of cell migration		Any process that modulates the frequency, rate, or extent of leukocyte migration.
http://purl.obolibrary.org/obo/GO_0002686	negative regulation of leukocyte migration	http://purl.obolibrary.org/obo/GO_0030336	negative regulation of cell migration		Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.
http://purl.obolibrary.org/obo/GO_0002687	positive regulation of leukocyte migration	http://purl.obolibrary.org/obo/GO_0030335	positive regulation of cell migration		Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
http://purl.obolibrary.org/obo/GO_0002688	regulation of leukocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0050920	regulation of chemotaxis		Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.
http://purl.obolibrary.org/obo/GO_0002689	negative regulation of leukocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0050922	negative regulation of chemotaxis		Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.
http://purl.obolibrary.org/obo/GO_0002690	positive regulation of leukocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0050921	positive regulation of chemotaxis		Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
http://purl.obolibrary.org/obo/GO_0002694	regulation of leukocyte activation	http://purl.obolibrary.org/obo/GO_0050865	regulation of cell activation		Any process that modulates the frequency, rate, or extent of leukocyte activation.
http://purl.obolibrary.org/obo/GO_0002695	negative regulation of leukocyte activation	http://purl.obolibrary.org/obo/GO_0050866	negative regulation of cell activation		Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
http://purl.obolibrary.org/obo/GO_0002696	positive regulation of leukocyte activation	http://purl.obolibrary.org/obo/GO_0050867	positive regulation of cell activation		Any process that activates or increases the frequency, rate, or extent of leukocyte activation.
http://purl.obolibrary.org/obo/GO_0002697	regulation of immune effector process	http://purl.obolibrary.org/obo/GO_0002682	regulation of immune system process		Any process that modulates the frequency, rate, or extent of an immune effector process.
http://purl.obolibrary.org/obo/GO_0002698	negative regulation of immune effector process	http://purl.obolibrary.org/obo/GO_0002697	regulation of immune effector process		Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
http://purl.obolibrary.org/obo/GO_0002699	positive regulation of immune effector process	http://purl.obolibrary.org/obo/GO_0002697	regulation of immune effector process		Any process that activates or increases the frequency, rate, or extent of an immune effector process.
http://purl.obolibrary.org/obo/GO_0002700	regulation of production of molecular mediator of immune response	http://purl.obolibrary.org/obo/GO_0010468	regulation of gene expression		Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.
http://purl.obolibrary.org/obo/GO_0002701	negative regulation of production of molecular mediator of immune response	http://purl.obolibrary.org/obo/GO_0002700	regulation of production of molecular mediator of immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.
http://purl.obolibrary.org/obo/GO_0002702	positive regulation of production of molecular mediator of immune response	http://purl.obolibrary.org/obo/GO_0010628	positive regulation of gene expression		Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.
http://purl.obolibrary.org/obo/GO_0002703	regulation of leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002697	regulation of immune effector process		Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002704	negative regulation of leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002703	regulation of leukocyte mediated immunity		Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002705	positive regulation of leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002703	regulation of leukocyte mediated immunity		Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002706	regulation of lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002703	regulation of leukocyte mediated immunity		Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002707	negative regulation of lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002706	regulation of lymphocyte mediated immunity		Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002708	positive regulation of lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002706	regulation of lymphocyte mediated immunity		Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002709	regulation of T cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that modulates the frequency, rate, or extent of T cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002710	negative regulation of T cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002711	positive regulation of T cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002712	regulation of B cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that modulates the frequency, rate, or extent of B cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002713	negative regulation of B cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002714	positive regulation of B cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002715	regulation of natural killer cell mediated immunity	http://purl.obolibrary.org/obo/GO_0045088	regulation of innate immune response		Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002716	negative regulation of natural killer cell mediated immunity	http://purl.obolibrary.org/obo/GO_0045824	negative regulation of innate immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002717	positive regulation of natural killer cell mediated immunity	http://purl.obolibrary.org/obo/GO_0045089	positive regulation of innate immune response		Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0002718	regulation of cytokine production involved in immune response	http://purl.obolibrary.org/obo/GO_0002700	regulation of production of molecular mediator of immune response		Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.
http://purl.obolibrary.org/obo/GO_0002719	negative regulation of cytokine production involved in immune response	http://purl.obolibrary.org/obo/GO_0002718	regulation of cytokine production involved in immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.
http://purl.obolibrary.org/obo/GO_0002720	positive regulation of cytokine production involved in immune response	http://purl.obolibrary.org/obo/GO_0002718	regulation of cytokine production involved in immune response		Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
http://purl.obolibrary.org/obo/GO_0002759	regulation of antimicrobial humoral response	http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response		Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.
http://purl.obolibrary.org/obo/GO_0002760	positive regulation of antimicrobial humoral response	http://purl.obolibrary.org/obo/GO_0032103	positive regulation of response to external stimulus		Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.
http://purl.obolibrary.org/obo/GO_0002761	regulation of myeloid leukocyte differentiation	http://purl.obolibrary.org/obo/GO_1902105	regulation of leukocyte differentiation		Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.
http://purl.obolibrary.org/obo/GO_0002762	negative regulation of myeloid leukocyte differentiation	http://purl.obolibrary.org/obo/GO_1902106	negative regulation of leukocyte differentiation		Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.
http://purl.obolibrary.org/obo/GO_0002763	positive regulation of myeloid leukocyte differentiation	http://purl.obolibrary.org/obo/GO_1902107	positive regulation of leukocyte differentiation		Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.
http://purl.obolibrary.org/obo/GO_0002775	antimicrobial peptide production	http://purl.obolibrary.org/obo/GO_0002440	production of molecular mediator of immune response		The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
http://purl.obolibrary.org/obo/GO_0002776	antimicrobial peptide secretion	http://purl.obolibrary.org/obo/GO_0002790	peptide secretion		The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.
http://purl.obolibrary.org/obo/GO_0002784	regulation of antimicrobial peptide production	http://purl.obolibrary.org/obo/GO_0002759	regulation of antimicrobial humoral response		Any process that modulates the frequency, rate, or extent of antimicrobial peptide production.
http://purl.obolibrary.org/obo/GO_0002785	negative regulation of antimicrobial peptide production	http://purl.obolibrary.org/obo/GO_0008348	negative regulation of antimicrobial humoral response		Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.
http://purl.obolibrary.org/obo/GO_0002790	peptide secretion	http://purl.obolibrary.org/obo/GO_0046903	secretion		The controlled release of a peptide from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0002791	regulation of peptide secretion	http://purl.obolibrary.org/obo/GO_0090087	regulation of peptide transport		Any process that modulates the frequency, rate, or extent of peptide secretion.
http://purl.obolibrary.org/obo/GO_0002792	negative regulation of peptide secretion	http://purl.obolibrary.org/obo/GO_0051048	negative regulation of secretion		Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.
http://purl.obolibrary.org/obo/GO_0002793	positive regulation of peptide secretion	http://purl.obolibrary.org/obo/GO_0051047	positive regulation of secretion		Any process that activates or increases the frequency, rate, or extent of peptide secretion.
http://purl.obolibrary.org/obo/GO_0002794	regulation of antimicrobial peptide secretion	http://purl.obolibrary.org/obo/GO_0002791	regulation of peptide secretion		Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.
http://purl.obolibrary.org/obo/GO_0002795	negative regulation of antimicrobial peptide secretion	http://purl.obolibrary.org/obo/GO_0002794	regulation of antimicrobial peptide secretion		Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion.
http://purl.obolibrary.org/obo/GO_0002796	positive regulation of antimicrobial peptide secretion	http://purl.obolibrary.org/obo/GO_0002794	regulation of antimicrobial peptide secretion		Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.
http://purl.obolibrary.org/obo/GO_0002819	regulation of adaptive immune response	http://purl.obolibrary.org/obo/GO_0050776	regulation of immune response		Any process that modulates the frequency, rate, or extent of an adaptive immune response.
http://purl.obolibrary.org/obo/GO_0002820	negative regulation of adaptive immune response	http://purl.obolibrary.org/obo/GO_0050777	negative regulation of immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
http://purl.obolibrary.org/obo/GO_0002821	positive regulation of adaptive immune response	http://purl.obolibrary.org/obo/GO_0050778	positive regulation of immune response		Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.
http://purl.obolibrary.org/obo/GO_0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	http://purl.obolibrary.org/obo/GO_0002819	regulation of adaptive immune response		Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
http://purl.obolibrary.org/obo/GO_0002823	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	http://purl.obolibrary.org/obo/GO_0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
http://purl.obolibrary.org/obo/GO_0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	http://purl.obolibrary.org/obo/GO_0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
http://purl.obolibrary.org/obo/GO_0002828	regulation of type 2 immune response	http://purl.obolibrary.org/obo/GO_0050776	regulation of immune response		Any process that modulates the frequency, rate, or extent of a type 2 immune response.
http://purl.obolibrary.org/obo/GO_0002829	negative regulation of type 2 immune response	http://purl.obolibrary.org/obo/GO_0050777	negative regulation of immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.
http://purl.obolibrary.org/obo/GO_0002830	positive regulation of type 2 immune response	http://purl.obolibrary.org/obo/GO_0050778	positive regulation of immune response		Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.
http://purl.obolibrary.org/obo/GO_0002831	regulation of response to biotic stimulus	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.
http://purl.obolibrary.org/obo/GO_0002832	negative regulation of response to biotic stimulus	http://purl.obolibrary.org/obo/GO_0048585	negative regulation of response to stimulus		Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.
http://purl.obolibrary.org/obo/GO_0002833	positive regulation of response to biotic stimulus	http://purl.obolibrary.org/obo/GO_0048584	positive regulation of response to stimulus		Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.
http://purl.obolibrary.org/obo/GO_0002886	regulation of myeloid leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002703	regulation of leukocyte mediated immunity		Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002887	negative regulation of myeloid leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002886	regulation of myeloid leukocyte mediated immunity		Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002888	positive regulation of myeloid leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002886	regulation of myeloid leukocyte mediated immunity		Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.
http://purl.obolibrary.org/obo/GO_0002889	regulation of immunoglobulin mediated immune response	http://purl.obolibrary.org/obo/GO_0002712	regulation of B cell mediated immunity		Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.
http://purl.obolibrary.org/obo/GO_0002890	negative regulation of immunoglobulin mediated immune response	http://purl.obolibrary.org/obo/GO_0002889	regulation of immunoglobulin mediated immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.
http://purl.obolibrary.org/obo/GO_0002891	positive regulation of immunoglobulin mediated immune response	http://purl.obolibrary.org/obo/GO_0002889	regulation of immunoglobulin mediated immune response		Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.
http://purl.obolibrary.org/obo/GO_0002920	regulation of humoral immune response	http://purl.obolibrary.org/obo/GO_0050776	regulation of immune response		Any process that modulates the frequency, rate, or extent of a humoral immune response.
http://purl.obolibrary.org/obo/GO_0002921	negative regulation of humoral immune response	http://purl.obolibrary.org/obo/GO_0050777	negative regulation of immune response		Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.
http://purl.obolibrary.org/obo/GO_0002922	positive regulation of humoral immune response	http://purl.obolibrary.org/obo/GO_0050778	positive regulation of immune response		Any process that activates or increases the frequency, rate, or extent of a humoral immune response.
http://purl.obolibrary.org/obo/GO_0003002	regionalization	http://purl.obolibrary.org/obo/GO_0007389	pattern specification process		The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
http://purl.obolibrary.org/obo/GO_0003006	developmental process involved in reproduction	http://purl.obolibrary.org/obo/GO_0032502	developmental process		A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.
http://purl.obolibrary.org/obo/GO_0003008	system process	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
http://purl.obolibrary.org/obo/GO_0003009	skeletal muscle contraction	http://purl.obolibrary.org/obo/GO_0006941	striated muscle contraction		A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.
http://purl.obolibrary.org/obo/GO_0003010	voluntary skeletal muscle contraction	http://purl.obolibrary.org/obo/GO_0003009	skeletal muscle contraction		A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.
http://purl.obolibrary.org/obo/GO_0003012	muscle system process	http://purl.obolibrary.org/obo/GO_0003008	system process		An organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
http://purl.obolibrary.org/obo/GO_0003013	circulatory system process	http://purl.obolibrary.org/obo/GO_0003008	system process		An organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
http://purl.obolibrary.org/obo/GO_0003014	renal system process	http://purl.obolibrary.org/obo/GO_0003008	system process		An organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
http://purl.obolibrary.org/obo/GO_0003015	heart process	http://purl.obolibrary.org/obo/GO_0003013	circulatory system process		A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
http://purl.obolibrary.org/obo/GO_0003016	respiratory system process	http://purl.obolibrary.org/obo/GO_0003008	system process		A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.
http://purl.obolibrary.org/obo/GO_0003032	detection of oxygen	http://purl.obolibrary.org/obo/GO_0070482	response to oxygen levels		The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0003044	regulation of systemic arterial blood pressure mediated by a chemical signal	http://purl.obolibrary.org/obo/GO_0003073	regulation of systemic arterial blood pressure		The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.
http://purl.obolibrary.org/obo/GO_0003071	renal system process involved in regulation of systemic arterial blood pressure	http://purl.obolibrary.org/obo/GO_0003014	renal system process		Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
http://purl.obolibrary.org/obo/GO_0003073	regulation of systemic arterial blood pressure	http://purl.obolibrary.org/obo/GO_0008217	regulation of blood pressure		The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
http://purl.obolibrary.org/obo/GO_0003081	regulation of systemic arterial blood pressure by renin-angiotensin	http://purl.obolibrary.org/obo/GO_0001990	regulation of systemic arterial blood pressure by hormone		The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.
http://purl.obolibrary.org/obo/GO_0003091	renal water homeostasis	http://purl.obolibrary.org/obo/GO_0050891	multicellular organismal-level water homeostasis		Renal process involved in the maintenance of an internal steady state of water in the body.
http://purl.obolibrary.org/obo/GO_0003093	regulation of glomerular filtration	http://purl.obolibrary.org/obo/GO_0098801	regulation of renal system process		Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.
http://purl.obolibrary.org/obo/GO_0003094	glomerular filtration	http://purl.obolibrary.org/obo/GO_0097205	renal filtration		The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
http://purl.obolibrary.org/obo/GO_0003097	renal water transport	http://purl.obolibrary.org/obo/GO_0006833	water transport		The directed movement of water (H2O) by the renal system.
http://purl.obolibrary.org/obo/GO_0003104	positive regulation of glomerular filtration	http://purl.obolibrary.org/obo/GO_0051240	positive regulation of multicellular organismal process		Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule.
http://purl.obolibrary.org/obo/GO_0003105	negative regulation of glomerular filtration	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule.
http://purl.obolibrary.org/obo/GO_0003330	regulation of extracellular matrix constituent secretion	http://purl.obolibrary.org/obo/GO_1903530	regulation of secretion by cell		Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
http://purl.obolibrary.org/obo/GO_0003331	positive regulation of extracellular matrix constituent secretion	http://purl.obolibrary.org/obo/GO_1903532	positive regulation of secretion by cell		Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
http://purl.obolibrary.org/obo/GO_0003332	negative regulation of extracellular matrix constituent secretion	http://purl.obolibrary.org/obo/GO_1903531	negative regulation of secretion by cell		Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
http://purl.obolibrary.org/obo/GO_0003341	cilium movement	http://purl.obolibrary.org/obo/GO_0007018	microtubule-based movement		The directed, self-propelled movement of a cilium.
http://purl.obolibrary.org/obo/GO_0003352	regulation of cilium movement	http://purl.obolibrary.org/obo/GO_0060632	regulation of microtubule-based movement		Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
http://purl.obolibrary.org/obo/GO_0003353	positive regulation of cilium movement	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
http://purl.obolibrary.org/obo/GO_0003354	negative regulation of cilium movement	http://purl.obolibrary.org/obo/GO_0003352	regulation of cilium movement		Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.
http://purl.obolibrary.org/obo/GO_0003824	catalytic activity	http://purl.obolibrary.org/obo/GO_0003674	molecular_function		Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
http://purl.obolibrary.org/obo/GO_0003857	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	http://purl.obolibrary.org/obo/GO_0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		Catalysis of the reaction: a (3S)-3-hydroxyacyl-CoA + NAD+ = a 3-oxoacyl-CoA + NADH + H+.
http://purl.obolibrary.org/obo/GO_0004035	alkaline phosphatase activity	http://purl.obolibrary.org/obo/GO_0016791	phosphatase activity		Catalysis of the reaction: a phosphate monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
http://purl.obolibrary.org/obo/GO_0004095	carnitine O-palmitoyltransferase activity	http://purl.obolibrary.org/obo/GO_0016416	O-palmitoyltransferase activity		Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.
http://purl.obolibrary.org/obo/GO_0004333	fumarate hydratase activity	http://purl.obolibrary.org/obo/GO_0016836	hydro-lyase activity		Catalysis of the reaction: (S)-malate = fumarate + H2O.
http://purl.obolibrary.org/obo/GO_0004494	methylmalonyl-CoA mutase activity	http://purl.obolibrary.org/obo/GO_0016866	intramolecular transferase activity		Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.
http://purl.obolibrary.org/obo/GO_0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	http://purl.obolibrary.org/obo/GO_0016798	hydrolase activity, acting on glycosyl bonds		Catalysis of the hydrolysis of any O-glycosyl bond.
http://purl.obolibrary.org/obo/GO_0004888	transmembrane signaling receptor activity	http://purl.obolibrary.org/obo/GO_0038023	signaling receptor activity		Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
http://purl.obolibrary.org/obo/GO_0004930	G protein-coupled receptor activity	http://purl.obolibrary.org/obo/GO_0004888	transmembrane signaling receptor activity		Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
http://purl.obolibrary.org/obo/GO_0005622	intracellular anatomical structure	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
http://purl.obolibrary.org/obo/GO_0005634	nucleus	http://purl.obolibrary.org/obo/GO_0043231	intracellular membrane-bounded organelle		A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
http://purl.obolibrary.org/obo/GO_0005694	chromosome	http://purl.obolibrary.org/obo/GO_0043232	intracellular membraneless organelle		A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
http://purl.obolibrary.org/obo/GO_0005737	cytoplasm	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
http://purl.obolibrary.org/obo/GO_0005739	mitochondrion	http://purl.obolibrary.org/obo/GO_0043231	intracellular membrane-bounded organelle		A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
http://purl.obolibrary.org/obo/GO_0005764	lysosome	http://purl.obolibrary.org/obo/GO_0000323	lytic vacuole		A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
http://purl.obolibrary.org/obo/GO_0005773	vacuole	http://purl.obolibrary.org/obo/GO_0043231	intracellular membrane-bounded organelle		A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
http://purl.obolibrary.org/obo/GO_0005775	vacuolar lumen	http://purl.obolibrary.org/obo/GO_0070013	intracellular organelle lumen		The volume enclosed within the vacuolar membrane.
http://purl.obolibrary.org/obo/GO_0005840	ribosome	http://purl.obolibrary.org/obo/GO_0043232	intracellular membraneless organelle		An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
http://purl.obolibrary.org/obo/GO_0005886	plasma membrane	http://purl.obolibrary.org/obo/GO_0016020	membrane		The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
http://purl.obolibrary.org/obo/GO_0005976	polysaccharide metabolic process	http://purl.obolibrary.org/obo/GO_0043170	macromolecule metabolic process		The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
http://purl.obolibrary.org/obo/GO_0005977	glycogen metabolic process	http://purl.obolibrary.org/obo/GO_0044042	glucan metabolic process		The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
http://purl.obolibrary.org/obo/GO_0006259	DNA metabolic process	http://purl.obolibrary.org/obo/GO_0090304	nucleic acid metabolic process		Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
http://purl.obolibrary.org/obo/GO_0006281	DNA repair	http://purl.obolibrary.org/obo/GO_0006974	DNA damage response		The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
http://purl.obolibrary.org/obo/GO_0006310	DNA recombination	http://purl.obolibrary.org/obo/GO_0006259	DNA metabolic process		Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
http://purl.obolibrary.org/obo/GO_0006412	translation	http://purl.obolibrary.org/obo/GO_0009059	macromolecule biosynthetic process		The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
http://purl.obolibrary.org/obo/GO_0006413	translational initiation	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
http://purl.obolibrary.org/obo/GO_0006414	translational elongation	http://purl.obolibrary.org/obo/GO_0009059	macromolecule biosynthetic process		The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
http://purl.obolibrary.org/obo/GO_0006415	translational termination	http://purl.obolibrary.org/obo/GO_0032984	protein-containing complex disassembly		The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
http://purl.obolibrary.org/obo/GO_0006508	proteolysis	http://purl.obolibrary.org/obo/GO_0019538	protein metabolic process		The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
http://purl.obolibrary.org/obo/GO_0006520	amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0044238	primary metabolic process		The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
http://purl.obolibrary.org/obo/GO_0006521	regulation of amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0080090	regulation of primary metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.
http://purl.obolibrary.org/obo/GO_0006575	modified amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
http://purl.obolibrary.org/obo/GO_0006672	ceramide metabolic process	http://purl.obolibrary.org/obo/GO_0006665	sphingolipid metabolic process		The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.
http://purl.obolibrary.org/obo/GO_0006687	glycosphingolipid metabolic process	http://purl.obolibrary.org/obo/GO_0006665	sphingolipid metabolic process		The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.
http://purl.obolibrary.org/obo/GO_0006790	sulfur compound metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
http://purl.obolibrary.org/obo/GO_0006833	water transport	http://purl.obolibrary.org/obo/GO_0042044	fluid transport		The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0006836	neurotransmitter transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
http://purl.obolibrary.org/obo/GO_0006865	amino acid transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0006869	lipid transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
http://purl.obolibrary.org/obo/GO_0006886	intracellular protein transport	http://purl.obolibrary.org/obo/GO_0046907	intracellular transport		The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
http://purl.obolibrary.org/obo/GO_0006909	phagocytosis	http://purl.obolibrary.org/obo/GO_0006897	endocytosis		A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
http://purl.obolibrary.org/obo/GO_0006915	apoptotic process	http://purl.obolibrary.org/obo/GO_0012501	programmed cell death		A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
http://purl.obolibrary.org/obo/GO_0006940	regulation of smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006937	regulation of muscle contraction		Any process that modulates the frequency, rate or extent of smooth muscle contraction.
http://purl.obolibrary.org/obo/GO_0006941	striated muscle contraction	http://purl.obolibrary.org/obo/GO_0006936	muscle contraction		A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
http://purl.obolibrary.org/obo/GO_0006950	response to stress	http://purl.obolibrary.org/obo/GO_0050896	response to stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
http://purl.obolibrary.org/obo/GO_0006952	defense response	http://purl.obolibrary.org/obo/GO_0006950	response to stress		Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
http://purl.obolibrary.org/obo/GO_0006954	inflammatory response	http://purl.obolibrary.org/obo/GO_0006952	defense response		The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
http://purl.obolibrary.org/obo/GO_0006955	immune response	http://purl.obolibrary.org/obo/GO_0002376	immune system process		Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
http://purl.obolibrary.org/obo/GO_0006956	complement activation	http://purl.obolibrary.org/obo/GO_0006959	humoral immune response		Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
http://purl.obolibrary.org/obo/GO_0006959	humoral immune response	http://purl.obolibrary.org/obo/GO_0006955	immune response		An immune response mediated through a body fluid.
http://purl.obolibrary.org/obo/GO_0006974	DNA damage response	http://purl.obolibrary.org/obo/GO_0033554	cellular response to stress		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
http://purl.obolibrary.org/obo/GO_0006997	nucleus organization	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
http://purl.obolibrary.org/obo/GO_0007005	mitochondrion organization	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
http://purl.obolibrary.org/obo/GO_0007009	plasma membrane organization	http://purl.obolibrary.org/obo/GO_0061024	membrane organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
http://purl.obolibrary.org/obo/GO_0007010	cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
http://purl.obolibrary.org/obo/GO_0007017	microtubule-based process	http://purl.obolibrary.org/obo/GO_0009987	cellular process		Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
http://purl.obolibrary.org/obo/GO_0007018	microtubule-based movement	http://purl.obolibrary.org/obo/GO_0007017	microtubule-based process		A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
http://purl.obolibrary.org/obo/GO_0007049	cell cycle	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
http://purl.obolibrary.org/obo/GO_0007154	cell communication	http://purl.obolibrary.org/obo/GO_0009987	cellular process		Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
http://purl.obolibrary.org/obo/GO_0007155	cell adhesion	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
http://purl.obolibrary.org/obo/GO_0007165	signal transduction	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
http://purl.obolibrary.org/obo/GO_0007166	cell surface receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0007165	signal transduction		The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
http://purl.obolibrary.org/obo/GO_0007186	G protein-coupled receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0007165	signal transduction		The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
http://purl.obolibrary.org/obo/GO_0007267	cell-cell signaling	http://purl.obolibrary.org/obo/GO_0023052	signaling		Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
http://purl.obolibrary.org/obo/GO_0007269	neurotransmitter secretion	http://purl.obolibrary.org/obo/GO_0006836	neurotransmitter transport		The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
http://purl.obolibrary.org/obo/GO_0007271	synaptic transmission, cholinergic	http://purl.obolibrary.org/obo/GO_0007268	chemical synaptic transmission		The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
http://purl.obolibrary.org/obo/GO_0007275	multicellular organism development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
http://purl.obolibrary.org/obo/GO_0007286	spermatid development	http://purl.obolibrary.org/obo/GO_0007281	germ cell development		The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
http://purl.obolibrary.org/obo/GO_0007369	gastrulation	http://purl.obolibrary.org/obo/GO_0048598	embryonic morphogenesis		A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
http://purl.obolibrary.org/obo/GO_0007389	pattern specification process	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
http://purl.obolibrary.org/obo/GO_0007398	ectoderm development	http://purl.obolibrary.org/obo/GO_0009888	tissue development		The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
http://purl.obolibrary.org/obo/GO_0007492	endoderm development	http://purl.obolibrary.org/obo/GO_0009888	tissue development		The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
http://purl.obolibrary.org/obo/GO_0007585	respiratory gaseous exchange by respiratory system	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.
http://purl.obolibrary.org/obo/GO_0007610	behavior	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
http://purl.obolibrary.org/obo/GO_0007623	circadian rhythm	http://purl.obolibrary.org/obo/GO_0048511	rhythmic process		Any biological process in an organism that recurs with a regularity of approximately 24 hours.
http://purl.obolibrary.org/obo/GO_0007631	feeding behavior	http://purl.obolibrary.org/obo/GO_0007610	behavior		Behavior associated with the intake of food.
http://purl.obolibrary.org/obo/GO_0008016	regulation of heart contraction	http://purl.obolibrary.org/obo/GO_1903522	regulation of blood circulation		Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
http://purl.obolibrary.org/obo/GO_0008206	bile acid metabolic process	http://purl.obolibrary.org/obo/GO_0032787	monocarboxylic acid metabolic process		The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
http://purl.obolibrary.org/obo/GO_0008217	regulation of blood pressure	http://purl.obolibrary.org/obo/GO_0065008	regulation of biological quality		Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
http://purl.obolibrary.org/obo/GO_0008283	cell population proliferation	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The multiplication or reproduction of cells, resulting in the expansion of a cell population.
http://purl.obolibrary.org/obo/GO_0008284	positive regulation of cell population proliferation	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the rate or extent of cell proliferation.
http://purl.obolibrary.org/obo/GO_0008348	negative regulation of antimicrobial humoral response	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.
http://purl.obolibrary.org/obo/GO_0008483	transaminase activity	http://purl.obolibrary.org/obo/GO_0016769	transferase activity, transferring nitrogenous groups		Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
http://purl.obolibrary.org/obo/GO_0009057	macromolecule catabolic process	http://purl.obolibrary.org/obo/GO_0009056	catabolic process		The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0009058	biosynthetic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
http://purl.obolibrary.org/obo/GO_0009059	macromolecule biosynthetic process	http://purl.obolibrary.org/obo/GO_0009058	biosynthetic process		The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0009306	protein secretion	http://purl.obolibrary.org/obo/GO_0071692	protein localization to extracellular region		The controlled release of proteins from a cell.
http://purl.obolibrary.org/obo/GO_0009593	detection of chemical stimulus	http://purl.obolibrary.org/obo/GO_0051606	detection of stimulus		The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0009605	response to external stimulus	http://purl.obolibrary.org/obo/GO_0050896	response to stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
http://purl.obolibrary.org/obo/GO_0009607	response to biotic stimulus	http://purl.obolibrary.org/obo/GO_0050896	response to stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
http://purl.obolibrary.org/obo/GO_0009611	response to wounding	http://purl.obolibrary.org/obo/GO_0006950	response to stress		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
http://purl.obolibrary.org/obo/GO_0009617	response to bacterium	http://purl.obolibrary.org/obo/GO_0051707	response to other organism		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
http://purl.obolibrary.org/obo/GO_0009653	anatomical structure morphogenesis	http://purl.obolibrary.org/obo/GO_0032502	developmental process		The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
http://purl.obolibrary.org/obo/GO_0009791	post-embryonic development	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.
http://purl.obolibrary.org/obo/GO_0009792	embryo development ending in birth or egg hatching	http://purl.obolibrary.org/obo/GO_0009790	embryo development		The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
http://purl.obolibrary.org/obo/GO_0009887	animal organ morphogenesis	http://purl.obolibrary.org/obo/GO_0009653	anatomical structure morphogenesis		Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
http://purl.obolibrary.org/obo/GO_0009888	tissue development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
http://purl.obolibrary.org/obo/GO_0009913	epidermal cell differentiation	http://purl.obolibrary.org/obo/GO_0030855	epithelial cell differentiation		The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
http://purl.obolibrary.org/obo/GO_0009914	hormone transport	http://purl.obolibrary.org/obo/GO_0010817	regulation of hormone levels		The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0009966	regulation of signal transduction	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that modulates the frequency, rate or extent of signal transduction.
http://purl.obolibrary.org/obo/GO_0009967	positive regulation of signal transduction	http://purl.obolibrary.org/obo/GO_0010647	positive regulation of cell communication		Any process that activates or increases the frequency, rate or extent of signal transduction.
http://purl.obolibrary.org/obo/GO_0009968	negative regulation of signal transduction	http://purl.obolibrary.org/obo/GO_0010648	negative regulation of cell communication		Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
http://purl.obolibrary.org/obo/GO_0009987	cellular process	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
http://purl.obolibrary.org/obo/GO_0010001	glial cell differentiation	http://purl.obolibrary.org/obo/GO_0030154	cell differentiation		The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
http://purl.obolibrary.org/obo/GO_0010463	mesenchymal cell proliferation	http://purl.obolibrary.org/obo/GO_0008283	cell population proliferation		The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
http://purl.obolibrary.org/obo/GO_0010464	regulation of mesenchymal cell proliferation	http://purl.obolibrary.org/obo/GO_0042127	regulation of cell population proliferation		Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
http://purl.obolibrary.org/obo/GO_0010467	gene expression	http://purl.obolibrary.org/obo/GO_0009059	macromolecule biosynthetic process		The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.
http://purl.obolibrary.org/obo/GO_0010468	regulation of gene expression	http://purl.obolibrary.org/obo/GO_0010556	regulation of macromolecule biosynthetic process		Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
http://purl.obolibrary.org/obo/GO_0010556	regulation of macromolecule biosynthetic process	http://purl.obolibrary.org/obo/GO_0009889	regulation of biosynthetic process		Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0010557	positive regulation of macromolecule biosynthetic process	http://purl.obolibrary.org/obo/GO_0009891	positive regulation of biosynthetic process		Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0010558	negative regulation of macromolecule biosynthetic process	http://purl.obolibrary.org/obo/GO_0009890	negative regulation of biosynthetic process		Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0010604	positive regulation of macromolecule metabolic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0010605	negative regulation of macromolecule metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0010646	regulation of cell communication	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
http://purl.obolibrary.org/obo/GO_0010817	regulation of hormone levels	http://purl.obolibrary.org/obo/GO_0065008	regulation of biological quality		Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.
http://purl.obolibrary.org/obo/GO_0010927	cellular component assembly involved in morphogenesis	http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis		The cellular component assembly that is part of the initial shaping of the component during its developmental progression.
http://purl.obolibrary.org/obo/GO_0010954	positive regulation of protein processing	http://purl.obolibrary.org/obo/GO_1903319	positive regulation of protein maturation		Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.
http://purl.obolibrary.org/obo/GO_0012501	programmed cell death	http://purl.obolibrary.org/obo/GO_0008219	cell death		A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
http://purl.obolibrary.org/obo/GO_0014020	primary neural tube formation	http://purl.obolibrary.org/obo/GO_0001838	embryonic epithelial tube formation		The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.
http://purl.obolibrary.org/obo/GO_0015629	actin cytoskeleton	http://purl.obolibrary.org/obo/GO_0005856	cytoskeleton		The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
http://purl.obolibrary.org/obo/GO_0015833	peptide transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0016049	cell growth	http://purl.obolibrary.org/obo/GO_0040007	growth		The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
http://purl.obolibrary.org/obo/GO_0016050	vesicle organization	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
http://purl.obolibrary.org/obo/GO_0016051	carbohydrate biosynthetic process	http://purl.obolibrary.org/obo/GO_0009058	biosynthetic process		The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
http://purl.obolibrary.org/obo/GO_0016052	carbohydrate catabolic process	http://purl.obolibrary.org/obo/GO_0009056	catabolic process		The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
http://purl.obolibrary.org/obo/GO_0016064	immunoglobulin mediated immune response	http://purl.obolibrary.org/obo/GO_0019724	B cell mediated immunity		An immune response mediated by immunoglobulins, whether cell-bound or in solution.
http://purl.obolibrary.org/obo/GO_0016070	RNA metabolic process	http://purl.obolibrary.org/obo/GO_0090304	nucleic acid metabolic process		The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
http://purl.obolibrary.org/obo/GO_0016101	diterpenoid metabolic process	http://purl.obolibrary.org/obo/GO_0006721	terpenoid metabolic process		The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.
http://purl.obolibrary.org/obo/GO_0016331	morphogenesis of embryonic epithelium	http://purl.obolibrary.org/obo/GO_0048598	embryonic morphogenesis		The process in which the anatomical structures of embryonic epithelia are generated and organized.
http://purl.obolibrary.org/obo/GO_0016406	carnitine O-acyltransferase activity	http://purl.obolibrary.org/obo/GO_0016747	acyltransferase activity, transferring groups other than amino-acyl groups		Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule.
http://purl.obolibrary.org/obo/GO_0016416	O-palmitoyltransferase activity	http://purl.obolibrary.org/obo/GO_0016409	palmitoyltransferase activity		Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule.
http://purl.obolibrary.org/obo/GO_0016421	CoA carboxylase activity	http://purl.obolibrary.org/obo/GO_0016885	ligase activity, forming carbon-carbon bonds		Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
http://purl.obolibrary.org/obo/GO_0016444	somatic cell DNA recombination	http://purl.obolibrary.org/obo/GO_0006310	DNA recombination		Recombination occurring within or between DNA molecules in somatic cells.
http://purl.obolibrary.org/obo/GO_0016445	somatic diversification of immunoglobulins	http://purl.obolibrary.org/obo/GO_0002200	somatic diversification of immune receptors		The somatic process that results in the generation of sequence diversity of immunoglobulins.
http://purl.obolibrary.org/obo/GO_0016446	somatic hypermutation of immunoglobulin genes	http://purl.obolibrary.org/obo/GO_0016445	somatic diversification of immunoglobulins		Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
http://purl.obolibrary.org/obo/GO_0016447	somatic recombination of immunoglobulin gene segments	http://purl.obolibrary.org/obo/GO_0016445	somatic diversification of immunoglobulins		The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.
http://purl.obolibrary.org/obo/GO_0016477	cell migration	http://purl.obolibrary.org/obo/GO_0048870	cell motility		The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
http://purl.obolibrary.org/obo/GO_0016485	protein processing	http://purl.obolibrary.org/obo/GO_0006508	proteolysis		Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
http://purl.obolibrary.org/obo/GO_0016491	oxidoreductase activity	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
http://purl.obolibrary.org/obo/GO_0016614	oxidoreductase activity, acting on CH-OH group of donors	http://purl.obolibrary.org/obo/GO_0016491	oxidoreductase activity		Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
http://purl.obolibrary.org/obo/GO_0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	http://purl.obolibrary.org/obo/GO_0016614	oxidoreductase activity, acting on CH-OH group of donors		Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
http://purl.obolibrary.org/obo/GO_0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	http://purl.obolibrary.org/obo/GO_0016667	oxidoreductase activity, acting on a sulfur group of donors		Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen.
http://purl.obolibrary.org/obo/GO_0016740	transferase activity	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
http://purl.obolibrary.org/obo/GO_0016747	acyltransferase activity, transferring groups other than amino-acyl groups	http://purl.obolibrary.org/obo/GO_0016746	acyltransferase activity		Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
http://purl.obolibrary.org/obo/GO_0016755	aminoacyltransferase activity	http://purl.obolibrary.org/obo/GO_0016746	acyltransferase activity		Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor).
http://purl.obolibrary.org/obo/GO_0016787	hydrolase activity	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
http://purl.obolibrary.org/obo/GO_0016791	phosphatase activity	http://purl.obolibrary.org/obo/GO_0042578	phosphoric ester hydrolase activity		Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate.
http://purl.obolibrary.org/obo/GO_0016829	lyase activity	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
http://purl.obolibrary.org/obo/GO_0016835	carbon-oxygen lyase activity	http://purl.obolibrary.org/obo/GO_0016829	lyase activity		Catalysis of the breakage of a carbon-oxygen bond.
http://purl.obolibrary.org/obo/GO_0016836	hydro-lyase activity	http://purl.obolibrary.org/obo/GO_0016835	carbon-oxygen lyase activity		Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
http://purl.obolibrary.org/obo/GO_0016853	isomerase activity	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
http://purl.obolibrary.org/obo/GO_0016866	intramolecular transferase activity	http://purl.obolibrary.org/obo/GO_0016853	isomerase activity		Catalysis of the transfer of a functional group from one position to another within a single molecule.
http://purl.obolibrary.org/obo/GO_0016874	ligase activity	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
http://purl.obolibrary.org/obo/GO_0017157	regulation of exocytosis	http://purl.obolibrary.org/obo/GO_0060627	regulation of vesicle-mediated transport		Any process that modulates the frequency, rate or extent of exocytosis.
http://purl.obolibrary.org/obo/GO_0019221	cytokine-mediated signaling pathway	http://purl.obolibrary.org/obo/GO_0007166	cell surface receptor signaling pathway		The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
http://purl.obolibrary.org/obo/GO_0019724	B cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains		Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
http://purl.obolibrary.org/obo/GO_0019730	antimicrobial humoral response	http://purl.obolibrary.org/obo/GO_0140546	defense response to symbiont		An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
http://purl.obolibrary.org/obo/GO_0019882	antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002376	immune system process		The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
http://purl.obolibrary.org/obo/GO_0019953	sexual reproduction	http://purl.obolibrary.org/obo/GO_0022414	reproductive process		A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).
http://purl.obolibrary.org/obo/GO_0021915	neural tube development	http://purl.obolibrary.org/obo/GO_0060429	epithelium development		The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
http://purl.obolibrary.org/obo/GO_0022402	cell cycle process	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
http://purl.obolibrary.org/obo/GO_0022403	cell cycle phase	http://purl.obolibrary.org/obo/GO_0044848	biological phase		One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
http://purl.obolibrary.org/obo/GO_0022412	cellular process involved in reproduction in multicellular organism	http://purl.obolibrary.org/obo/GO_0009987	cellular process		A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.
http://purl.obolibrary.org/obo/GO_0022414	reproductive process	http://purl.obolibrary.org/obo/GO_0008150	biological_process		A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
http://purl.obolibrary.org/obo/GO_0022600	digestive system process	http://purl.obolibrary.org/obo/GO_0003008	system process		A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
http://purl.obolibrary.org/obo/GO_0022603	regulation of anatomical structure morphogenesis	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.
http://purl.obolibrary.org/obo/GO_0022607	cellular component assembly	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		The aggregation, arrangement and bonding together of a cellular component.
http://purl.obolibrary.org/obo/GO_0022618	protein-RNA complex assembly	http://purl.obolibrary.org/obo/GO_0071826	protein-RNA complex organization		The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.
http://purl.obolibrary.org/obo/GO_0023051	regulation of signaling	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of a signaling process.
http://purl.obolibrary.org/obo/GO_0023056	positive regulation of signaling	http://purl.obolibrary.org/obo/GO_0048518	positive regulation of biological process		Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
http://purl.obolibrary.org/obo/GO_0023057	negative regulation of signaling	http://purl.obolibrary.org/obo/GO_0048519	negative regulation of biological process		Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.
http://purl.obolibrary.org/obo/GO_0030097	hemopoiesis	http://purl.obolibrary.org/obo/GO_0048468	cell development		The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
http://purl.obolibrary.org/obo/GO_0030098	lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_1903131	mononuclear cell differentiation		The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
http://purl.obolibrary.org/obo/GO_0030099	myeloid cell differentiation	http://purl.obolibrary.org/obo/GO_0030154	cell differentiation		The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
http://purl.obolibrary.org/obo/GO_0030103	vasopressin secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of vasopressin from secretory granules into the blood.
http://purl.obolibrary.org/obo/GO_0030141	secretory granule	http://purl.obolibrary.org/obo/GO_0099503	secretory vesicle		A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
http://purl.obolibrary.org/obo/GO_0030154	cell differentiation	http://purl.obolibrary.org/obo/GO_0048869	cellular developmental process		The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
http://purl.obolibrary.org/obo/GO_0030155	regulation of cell adhesion	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
http://purl.obolibrary.org/obo/GO_0030183	B cell differentiation	http://purl.obolibrary.org/obo/GO_0042113	B cell activation		The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
http://purl.obolibrary.org/obo/GO_0030194	positive regulation of blood coagulation	http://purl.obolibrary.org/obo/GO_0030193	regulation of blood coagulation		Any process that activates or increases the frequency, rate or extent of blood coagulation.
http://purl.obolibrary.org/obo/GO_0030203	glycosaminoglycan metabolic process	http://purl.obolibrary.org/obo/GO_0006022	aminoglycan metabolic process		The chemical reactions and pathways involving glycosaminoglycans, any of a group of linear polysaccharides composed of repeating disaccharide units.
http://purl.obolibrary.org/obo/GO_0030216	keratinocyte differentiation	http://purl.obolibrary.org/obo/GO_0009913	epidermal cell differentiation		The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
http://purl.obolibrary.org/obo/GO_0030217	T cell differentiation	http://purl.obolibrary.org/obo/GO_0042110	T cell activation		The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
http://purl.obolibrary.org/obo/GO_0030261	chromosome condensation	http://purl.obolibrary.org/obo/GO_0051276	chromosome organization		The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
http://purl.obolibrary.org/obo/GO_0030334	regulation of cell migration	http://purl.obolibrary.org/obo/GO_2000145	regulation of cell motility		Any process that modulates the frequency, rate or extent of cell migration.
http://purl.obolibrary.org/obo/GO_0030335	positive regulation of cell migration	http://purl.obolibrary.org/obo/GO_2000147	positive regulation of cell motility		Any process that activates or increases the frequency, rate or extent of cell migration.
http://purl.obolibrary.org/obo/GO_0030336	negative regulation of cell migration	http://purl.obolibrary.org/obo/GO_2000146	negative regulation of cell motility		Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
http://purl.obolibrary.org/obo/GO_0030449	regulation of complement activation	http://purl.obolibrary.org/obo/GO_0002920	regulation of humoral immune response		Any process that modulates the frequency, rate or extent of complement activation.
http://purl.obolibrary.org/obo/GO_0030595	leukocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0050900	leukocyte migration		The movement of a leukocyte in response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0030667	secretory granule membrane	http://purl.obolibrary.org/obo/GO_0030659	cytoplasmic vesicle membrane		The lipid bilayer surrounding a secretory granule.
http://purl.obolibrary.org/obo/GO_0030855	epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0030154	cell differentiation		The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
http://purl.obolibrary.org/obo/GO_0030857	negative regulation of epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0030856	regulation of epithelial cell differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.
http://purl.obolibrary.org/obo/GO_0030879	mammary gland development	http://purl.obolibrary.org/obo/GO_0048732	gland development		The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
http://purl.obolibrary.org/obo/GO_0031333	negative regulation of protein-containing complex assembly	http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization		Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
http://purl.obolibrary.org/obo/GO_0031334	positive regulation of protein-containing complex assembly	http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization		Any process that activates or increases the frequency, rate or extent of protein complex assembly.
http://purl.obolibrary.org/obo/GO_0031341	regulation of cell killing	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.
http://purl.obolibrary.org/obo/GO_0031342	negative regulation of cell killing	http://purl.obolibrary.org/obo/GO_0031341	regulation of cell killing		Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.
http://purl.obolibrary.org/obo/GO_0031343	positive regulation of cell killing	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of cell killing.
http://purl.obolibrary.org/obo/GO_0031348	negative regulation of defense response	http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response		Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.
http://purl.obolibrary.org/obo/GO_0031349	positive regulation of defense response	http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response		Any process that activates or increases the frequency, rate or extent of a defense response.
http://purl.obolibrary.org/obo/GO_0031410	cytoplasmic vesicle	http://purl.obolibrary.org/obo/GO_0097708	intracellular vesicle		A vesicle found in the cytoplasm of a cell.
http://purl.obolibrary.org/obo/GO_0031640	killing of cells of another organism	http://purl.obolibrary.org/obo/GO_0001906	cell killing		Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
http://purl.obolibrary.org/obo/GO_0031667	response to nutrient levels	http://purl.obolibrary.org/obo/GO_0050896	response to stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
http://purl.obolibrary.org/obo/GO_0031981	nuclear lumen	http://purl.obolibrary.org/obo/GO_0070013	intracellular organelle lumen		The volume enclosed by the nuclear inner membrane.
http://purl.obolibrary.org/obo/GO_0032101	regulation of response to external stimulus	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that modulates the frequency, rate or extent of a response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0032103	positive regulation of response to external stimulus	http://purl.obolibrary.org/obo/GO_0048584	positive regulation of response to stimulus		Any process that activates, maintains or increases the rate of a response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0032432	actin filament bundle	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
http://purl.obolibrary.org/obo/GO_0032502	developmental process	http://purl.obolibrary.org/obo/GO_0008150	biological_process		A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
http://purl.obolibrary.org/obo/GO_0032940	secretion by cell	http://purl.obolibrary.org/obo/GO_0046903	secretion		The controlled release of a substance by a cell.
http://purl.obolibrary.org/obo/GO_0032984	protein-containing complex disassembly	http://purl.obolibrary.org/obo/GO_0043933	protein-containing complex organization		The disaggregation of a protein-containing macromolecular complex into its constituent components.
http://purl.obolibrary.org/obo/GO_0032989	cellular anatomical entity morphogenesis	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system.
http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex	http://purl.obolibrary.org/obo/GO_0005575	cellular_component		A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
http://purl.obolibrary.org/obo/GO_0033363	secretory granule organization	http://purl.obolibrary.org/obo/GO_0016050	vesicle organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
http://purl.obolibrary.org/obo/GO_0033554	cellular response to stress	http://purl.obolibrary.org/obo/GO_0006950	response to stress		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
http://purl.obolibrary.org/obo/GO_0034109	homotypic cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0098609	cell-cell adhesion		The attachment of a cell to a second cell of the identical type via adhesion molecules.
http://purl.obolibrary.org/obo/GO_0035282	segmentation	http://purl.obolibrary.org/obo/GO_0003002	regionalization		The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.
http://purl.obolibrary.org/obo/GO_0035556	intracellular signal transduction	http://purl.obolibrary.org/obo/GO_0007165	signal transduction		The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
http://purl.obolibrary.org/obo/GO_0035932	aldosterone secretion	http://purl.obolibrary.org/obo/GO_0035931	mineralocorticoid secretion		The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
http://purl.obolibrary.org/obo/GO_0036072	direct ossification	http://purl.obolibrary.org/obo/GO_0001503	ossification		The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.
http://purl.obolibrary.org/obo/GO_0036075	replacement ossification	http://purl.obolibrary.org/obo/GO_0001503	ossification		Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation.
http://purl.obolibrary.org/obo/GO_0036293	response to decreased oxygen levels	http://purl.obolibrary.org/obo/GO_0070482	response to oxygen levels		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
http://purl.obolibrary.org/obo/GO_0038023	signaling receptor activity	http://purl.obolibrary.org/obo/GO_0060089	molecular transducer activity		Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
http://purl.obolibrary.org/obo/GO_0040007	growth	http://purl.obolibrary.org/obo/GO_0008150	biological_process		The increase in size or mass of an entire organism, a part of an organism or a cell.
http://purl.obolibrary.org/obo/GO_0040008	regulation of growth	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
http://purl.obolibrary.org/obo/GO_0042060	wound healing	http://purl.obolibrary.org/obo/GO_0009611	response to wounding		The series of events that restore integrity to a damaged tissue, following an injury.
http://purl.obolibrary.org/obo/GO_0042074	cell migration involved in gastrulation	http://purl.obolibrary.org/obo/GO_0001667	ameboidal-type cell migration		The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
http://purl.obolibrary.org/obo/GO_0042092	type 2 immune response	http://purl.obolibrary.org/obo/GO_0006955	immune response		An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.
http://purl.obolibrary.org/obo/GO_0042098	T cell proliferation	http://purl.obolibrary.org/obo/GO_0046651	lymphocyte proliferation		The expansion of a T cell population by cell division. Follows T cell activation.
http://purl.obolibrary.org/obo/GO_0042100	B cell proliferation	http://purl.obolibrary.org/obo/GO_0046651	lymphocyte proliferation		The expansion of a B cell population by cell division. Follows B cell activation.
http://purl.obolibrary.org/obo/GO_0042110	T cell activation	http://purl.obolibrary.org/obo/GO_0046649	lymphocyte activation		The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
http://purl.obolibrary.org/obo/GO_0042113	B cell activation	http://purl.obolibrary.org/obo/GO_0046649	lymphocyte activation		The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
http://purl.obolibrary.org/obo/GO_0042127	regulation of cell population proliferation	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of cell proliferation.
http://purl.obolibrary.org/obo/GO_0042221	response to chemical	http://purl.obolibrary.org/obo/GO_0050896	response to stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
http://purl.obolibrary.org/obo/GO_0042330	taxis	http://purl.obolibrary.org/obo/GO_0040011	locomotion		The directed movement of a motile cell or organism in response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0042391	regulation of membrane potential	http://purl.obolibrary.org/obo/GO_0065008	regulation of biological quality		Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
http://purl.obolibrary.org/obo/GO_0042492	gamma-delta T cell differentiation	http://purl.obolibrary.org/obo/GO_0046629	gamma-delta T cell activation		The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.
http://purl.obolibrary.org/obo/GO_0042592	homeostatic process	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any biological process involved in the maintenance of an internal steady state. Homeostasis allows cells and organisms to maintain stable internal conditions despite varying external conditions.
http://purl.obolibrary.org/obo/GO_0042593	glucose homeostasis	http://purl.obolibrary.org/obo/GO_0033500	carbohydrate homeostasis		Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
http://purl.obolibrary.org/obo/GO_0042645	mitochondrial nucleoid	http://purl.obolibrary.org/obo/GO_0009295	nucleoid		The region of a mitochondrion to which the DNA is confined.
http://purl.obolibrary.org/obo/GO_0042755	eating behavior	http://purl.obolibrary.org/obo/GO_0007631	feeding behavior		The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
http://purl.obolibrary.org/obo/GO_0042756	drinking behavior	http://purl.obolibrary.org/obo/GO_0007631	feeding behavior		The specific behavior of an organism relating to the intake of liquids, especially water.
http://purl.obolibrary.org/obo/GO_0042981	regulation of apoptotic process	http://purl.obolibrary.org/obo/GO_0043067	regulation of programmed cell death		Any process that modulates the occurrence or rate of cell death by apoptotic process.
http://purl.obolibrary.org/obo/GO_0042995	cell projection	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A prolongation or process extending from a cell, e.g. a flagellum or axon.
http://purl.obolibrary.org/obo/GO_0043009	chordate embryonic development	http://purl.obolibrary.org/obo/GO_0009792	embryo development ending in birth or egg hatching		The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
http://purl.obolibrary.org/obo/GO_0043011	myeloid dendritic cell differentiation	http://purl.obolibrary.org/obo/GO_0097028	dendritic cell differentiation		The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.
http://purl.obolibrary.org/obo/GO_0043207	response to external biotic stimulus	http://purl.obolibrary.org/obo/GO_0009607	response to biotic stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.
http://purl.obolibrary.org/obo/GO_0043226	organelle	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
http://purl.obolibrary.org/obo/GO_0043232	intracellular membraneless organelle	http://purl.obolibrary.org/obo/GO_0043228	membraneless organelle		Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
http://purl.obolibrary.org/obo/GO_0043235	signaling receptor complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		Any protein complex that binds a signaling molecule such as a hormone, neurotransmitter, molecular pattern recognition receptor (PAMPs and DAMPS), or an intracellular messenger to initiate a change in cell function.
http://purl.obolibrary.org/obo/GO_0043254	regulation of protein-containing complex assembly	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of protein complex assembly.
http://purl.obolibrary.org/obo/GO_0043436	oxoacid metabolic process	http://purl.obolibrary.org/obo/GO_0044281	small molecule metabolic process		The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
http://purl.obolibrary.org/obo/GO_0043467	regulation of generation of precursor metabolites and energy	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.
http://purl.obolibrary.org/obo/GO_0043933	protein-containing complex organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.
http://purl.obolibrary.org/obo/GO_0044065	regulation of respiratory system process	http://purl.obolibrary.org/obo/GO_0043576	regulation of respiratory gaseous exchange		Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.
http://purl.obolibrary.org/obo/GO_0044282	small molecule catabolic process	http://purl.obolibrary.org/obo/GO_0009056	catabolic process		The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.
http://purl.obolibrary.org/obo/GO_0044283	small molecule biosynthetic process	http://purl.obolibrary.org/obo/GO_0009058	biosynthetic process		The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
http://purl.obolibrary.org/obo/GO_0044703	multi-organism reproductive process	http://purl.obolibrary.org/obo/GO_0022414	reproductive process		A biological process that directly contributes to the process of producing new individuals, involving another organism.
http://purl.obolibrary.org/obo/GO_0044848	biological phase	http://purl.obolibrary.org/obo/GO_0008150	biological_process		A distinct period or stage in a biological process or cycle.
http://purl.obolibrary.org/obo/GO_0045055	regulated exocytosis	http://purl.obolibrary.org/obo/GO_0006887	exocytosis		A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
http://purl.obolibrary.org/obo/GO_0045087	innate immune response	http://purl.obolibrary.org/obo/GO_0140546	defense response to symbiont		Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
http://purl.obolibrary.org/obo/GO_0045088	regulation of innate immune response	http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response		Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
http://purl.obolibrary.org/obo/GO_0045089	positive regulation of innate immune response	http://purl.obolibrary.org/obo/GO_0050778	positive regulation of immune response		Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
http://purl.obolibrary.org/obo/GO_0045321	leukocyte activation	http://purl.obolibrary.org/obo/GO_0002376	immune system process		A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.
http://purl.obolibrary.org/obo/GO_0045577	regulation of B cell differentiation	http://purl.obolibrary.org/obo/GO_0050864	regulation of B cell activation		Any process that modulates the frequency, rate or extent of B cell differentiation.
http://purl.obolibrary.org/obo/GO_0045578	negative regulation of B cell differentiation	http://purl.obolibrary.org/obo/GO_0050869	negative regulation of B cell activation		Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.
http://purl.obolibrary.org/obo/GO_0045579	positive regulation of B cell differentiation	http://purl.obolibrary.org/obo/GO_0050871	positive regulation of B cell activation		Any process that activates or increases the frequency, rate or extent of B cell differentiation.
http://purl.obolibrary.org/obo/GO_0045637	regulation of myeloid cell differentiation	http://purl.obolibrary.org/obo/GO_1903706	regulation of hemopoiesis		Any process that modulates the frequency, rate or extent of myeloid cell differentiation.
http://purl.obolibrary.org/obo/GO_0045638	negative regulation of myeloid cell differentiation	http://purl.obolibrary.org/obo/GO_0045637	regulation of myeloid cell differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
http://purl.obolibrary.org/obo/GO_0045639	positive regulation of myeloid cell differentiation	http://purl.obolibrary.org/obo/GO_0045597	positive regulation of cell differentiation		Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.
http://purl.obolibrary.org/obo/GO_0045730	respiratory burst	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0045744	negative regulation of G protein-coupled receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0008277	regulation of G protein-coupled receptor signaling pathway		Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.
http://purl.obolibrary.org/obo/GO_0045786	negative regulation of cell cycle	http://purl.obolibrary.org/obo/GO_0051726	regulation of cell cycle		Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
http://purl.obolibrary.org/obo/GO_0045822	negative regulation of heart contraction	http://purl.obolibrary.org/obo/GO_0008016	regulation of heart contraction		Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
http://purl.obolibrary.org/obo/GO_0045823	positive regulation of heart contraction	http://purl.obolibrary.org/obo/GO_0008016	regulation of heart contraction		Any process that activates or increases the frequency, rate or extent of heart contraction.
http://purl.obolibrary.org/obo/GO_0045824	negative regulation of innate immune response	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.
http://purl.obolibrary.org/obo/GO_0045839	negative regulation of mitotic nuclear division	http://purl.obolibrary.org/obo/GO_0010948	negative regulation of cell cycle process		Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
http://purl.obolibrary.org/obo/GO_0045910	negative regulation of DNA recombination	http://purl.obolibrary.org/obo/GO_0000018	regulation of DNA recombination		Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.
http://purl.obolibrary.org/obo/GO_0045911	positive regulation of DNA recombination	http://purl.obolibrary.org/obo/GO_0051054	positive regulation of DNA metabolic process		Any process that activates or increases the frequency, rate or extent of DNA recombination.
http://purl.obolibrary.org/obo/GO_0045916	negative regulation of complement activation	http://purl.obolibrary.org/obo/GO_0030449	regulation of complement activation		Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.
http://purl.obolibrary.org/obo/GO_0045917	positive regulation of complement activation	http://purl.obolibrary.org/obo/GO_0030449	regulation of complement activation		Any process that activates or increases the frequency, rate or extent of complement activation.
http://purl.obolibrary.org/obo/GO_0045920	negative regulation of exocytosis	http://purl.obolibrary.org/obo/GO_1903531	negative regulation of secretion by cell		Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
http://purl.obolibrary.org/obo/GO_0045921	positive regulation of exocytosis	http://purl.obolibrary.org/obo/GO_1903532	positive regulation of secretion by cell		Any process that activates or increases the frequency, rate or extent of exocytosis.
http://purl.obolibrary.org/obo/GO_0045995	regulation of embryonic development	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of embryonic development.
http://purl.obolibrary.org/obo/GO_0046394	carboxylic acid biosynthetic process	http://purl.obolibrary.org/obo/GO_0044283	small molecule biosynthetic process		The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
http://purl.obolibrary.org/obo/GO_0046620	regulation of organ growth	http://purl.obolibrary.org/obo/GO_0048638	regulation of developmental growth		Any process that modulates the frequency, rate or extent of growth of an organ of an organism.
http://purl.obolibrary.org/obo/GO_0046629	gamma-delta T cell activation	http://purl.obolibrary.org/obo/GO_0042110	T cell activation		The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
http://purl.obolibrary.org/obo/GO_0046649	lymphocyte activation	http://purl.obolibrary.org/obo/GO_0045321	leukocyte activation		A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.
http://purl.obolibrary.org/obo/GO_0046651	lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0032943	mononuclear cell proliferation		The expansion of a lymphocyte population by cell division.
http://purl.obolibrary.org/obo/GO_0046661	male sex differentiation	http://purl.obolibrary.org/obo/GO_0007548	sex differentiation		The establishment of the sex of a male organism by physical differentiation.
http://purl.obolibrary.org/obo/GO_0046717	acid secretion	http://purl.obolibrary.org/obo/GO_0046903	secretion		The controlled release of acid by a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0046879	hormone secretion	http://purl.obolibrary.org/obo/GO_0023061	signal release		The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
http://purl.obolibrary.org/obo/GO_0046903	secretion	http://purl.obolibrary.org/obo/GO_0006810	transport		The controlled release of a substance by a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0046928	regulation of neurotransmitter secretion	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
http://purl.obolibrary.org/obo/GO_0048284	organelle fusion	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		The creation of a single organelle from two or more organelles.
http://purl.obolibrary.org/obo/GO_0048285	organelle fission	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		The creation of two or more organelles by division of one organelle.
http://purl.obolibrary.org/obo/GO_0048332	mesoderm morphogenesis	http://purl.obolibrary.org/obo/GO_0048729	tissue morphogenesis		The process in which the anatomical structures of the mesoderm are generated and organized.
http://purl.obolibrary.org/obo/GO_0048468	cell development	http://purl.obolibrary.org/obo/GO_0048869	cellular developmental process		The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place.
http://purl.obolibrary.org/obo/GO_0048469	cell maturation	http://purl.obolibrary.org/obo/GO_0071695	anatomical structure maturation		The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state.
http://purl.obolibrary.org/obo/GO_0048513	animal organ development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
http://purl.obolibrary.org/obo/GO_0048514	blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_0035239	tube morphogenesis		The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
http://purl.obolibrary.org/obo/GO_0048518	positive regulation of biological process	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
http://purl.obolibrary.org/obo/GO_0048519	negative regulation of biological process	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
http://purl.obolibrary.org/obo/GO_0048584	positive regulation of response to stimulus	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
http://purl.obolibrary.org/obo/GO_0048585	negative regulation of response to stimulus	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
http://purl.obolibrary.org/obo/GO_0048588	developmental cell growth	http://purl.obolibrary.org/obo/GO_0048589	developmental growth		The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
http://purl.obolibrary.org/obo/GO_0048589	developmental growth	http://purl.obolibrary.org/obo/GO_0040007	growth		The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
http://purl.obolibrary.org/obo/GO_0048598	embryonic morphogenesis	http://purl.obolibrary.org/obo/GO_0009653	anatomical structure morphogenesis		The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis	http://purl.obolibrary.org/obo/GO_0032502	developmental process		The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
http://purl.obolibrary.org/obo/GO_0048699	generation of neurons	http://purl.obolibrary.org/obo/GO_0022008	neurogenesis		The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
http://purl.obolibrary.org/obo/GO_0048705	skeletal system morphogenesis	http://purl.obolibrary.org/obo/GO_0009887	animal organ morphogenesis		The process in which the anatomical structures of the skeleton are generated and organized.
http://purl.obolibrary.org/obo/GO_0048729	tissue morphogenesis	http://purl.obolibrary.org/obo/GO_0009653	anatomical structure morphogenesis		The process in which the anatomical structures of a tissue are generated and organized.
http://purl.obolibrary.org/obo/GO_0048731	system development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
http://purl.obolibrary.org/obo/GO_0048732	gland development	http://purl.obolibrary.org/obo/GO_0048513	animal organ development		The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.
http://purl.obolibrary.org/obo/GO_0048754	branching morphogenesis of an epithelial tube	http://purl.obolibrary.org/obo/GO_0061138	morphogenesis of a branching epithelium		The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
http://purl.obolibrary.org/obo/GO_0048771	tissue remodeling	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.
http://purl.obolibrary.org/obo/GO_0048845	venous blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_0048514	blood vessel morphogenesis		The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.
http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development	http://purl.obolibrary.org/obo/GO_0032502	developmental process		The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
http://purl.obolibrary.org/obo/GO_0048869	cellular developmental process	http://purl.obolibrary.org/obo/GO_0032502	developmental process		A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
http://purl.obolibrary.org/obo/GO_0048870	cell motility	http://purl.obolibrary.org/obo/GO_0009987	cellular process		Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
http://purl.obolibrary.org/obo/GO_0048871	multicellular organismal-level homeostasis	http://purl.obolibrary.org/obo/GO_0042592	homeostatic process		Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.
http://purl.obolibrary.org/obo/GO_0048872	homeostasis of number of cells	http://purl.obolibrary.org/obo/GO_0048871	multicellular organismal-level homeostasis		Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
http://purl.obolibrary.org/obo/GO_0050673	epithelial cell proliferation	http://purl.obolibrary.org/obo/GO_0008283	cell population proliferation		The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
http://purl.obolibrary.org/obo/GO_0050678	regulation of epithelial cell proliferation	http://purl.obolibrary.org/obo/GO_0042127	regulation of cell population proliferation		Any process that modulates the frequency, rate or extent of epithelial cell proliferation.
http://purl.obolibrary.org/obo/GO_0050679	positive regulation of epithelial cell proliferation	http://purl.obolibrary.org/obo/GO_0050678	regulation of epithelial cell proliferation		Any process that activates or increases the rate or extent of epithelial cell proliferation.
http://purl.obolibrary.org/obo/GO_0050680	negative regulation of epithelial cell proliferation	http://purl.obolibrary.org/obo/GO_0008285	negative regulation of cell population proliferation		Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
http://purl.obolibrary.org/obo/GO_0050727	regulation of inflammatory response	http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response		Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
http://purl.obolibrary.org/obo/GO_0050728	negative regulation of inflammatory response	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
http://purl.obolibrary.org/obo/GO_0050729	positive regulation of inflammatory response	http://purl.obolibrary.org/obo/GO_0050727	regulation of inflammatory response		Any process that activates or increases the frequency, rate or extent of the inflammatory response.
http://purl.obolibrary.org/obo/GO_0050769	positive regulation of neurogenesis	http://purl.obolibrary.org/obo/GO_0050767	regulation of neurogenesis		Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
http://purl.obolibrary.org/obo/GO_0050776	regulation of immune response	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
http://purl.obolibrary.org/obo/GO_0050777	negative regulation of immune response	http://purl.obolibrary.org/obo/GO_0050776	regulation of immune response		Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
http://purl.obolibrary.org/obo/GO_0050778	positive regulation of immune response	http://purl.obolibrary.org/obo/GO_0050776	regulation of immune response		Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process	http://purl.obolibrary.org/obo/GO_0065007	biological regulation		Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
http://purl.obolibrary.org/obo/GO_0050806	positive regulation of synaptic transmission	http://purl.obolibrary.org/obo/GO_0010647	positive regulation of cell communication		Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
http://purl.obolibrary.org/obo/GO_0050865	regulation of cell activation	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
http://purl.obolibrary.org/obo/GO_0050866	negative regulation of cell activation	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.
http://purl.obolibrary.org/obo/GO_0050867	positive regulation of cell activation	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of activation.
http://purl.obolibrary.org/obo/GO_0050877	nervous system process	http://purl.obolibrary.org/obo/GO_0003008	system process		An organ system process carried out by any of the organs or tissues of the neurological system.
http://purl.obolibrary.org/obo/GO_0050878	regulation of body fluid levels	http://purl.obolibrary.org/obo/GO_0065008	regulation of biological quality		Any process that modulates the levels of body fluids.
http://purl.obolibrary.org/obo/GO_0050881	musculoskeletal movement	http://purl.obolibrary.org/obo/GO_0050879	multicellular organismal movement		The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.
http://purl.obolibrary.org/obo/GO_0050886	endocrine process	http://purl.obolibrary.org/obo/GO_0003008	system process		The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.
http://purl.obolibrary.org/obo/GO_0050891	multicellular organismal-level water homeostasis	http://purl.obolibrary.org/obo/GO_0140962	multicellular organismal-level chemical homeostasis		A chemical homeostatic process involved in the maintenance of a steady state level of water within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
http://purl.obolibrary.org/obo/GO_0050892	intestinal absorption	http://purl.obolibrary.org/obo/GO_0022600	digestive system process		A process in which nutrients are taken up from the contents of the intestine.
http://purl.obolibrary.org/obo/GO_0050900	leukocyte migration	http://purl.obolibrary.org/obo/GO_0016477	cell migration		The movement of a leukocyte within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_0050905	neuromuscular process	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		Any process pertaining to the functions of the nervous and muscular systems of an organism.
http://purl.obolibrary.org/obo/GO_0050912	detection of chemical stimulus involved in sensory perception of taste	http://purl.obolibrary.org/obo/GO_0050907	detection of chemical stimulus involved in sensory perception		The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0050920	regulation of chemotaxis	http://purl.obolibrary.org/obo/GO_0040012	regulation of locomotion		Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
http://purl.obolibrary.org/obo/GO_0050921	positive regulation of chemotaxis	http://purl.obolibrary.org/obo/GO_0040017	positive regulation of locomotion		Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
http://purl.obolibrary.org/obo/GO_0050922	negative regulation of chemotaxis	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
http://purl.obolibrary.org/obo/GO_0050982	detection of mechanical stimulus	http://purl.obolibrary.org/obo/GO_0009582	detection of abiotic stimulus		The series of events by which a mechanical stimulus is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0051046	regulation of secretion	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0051047	positive regulation of secretion	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0051048	negative regulation of secretion	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0051052	regulation of DNA metabolic process	http://purl.obolibrary.org/obo/GO_0060255	regulation of macromolecule metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.
http://purl.obolibrary.org/obo/GO_0051093	negative regulation of developmental process	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
http://purl.obolibrary.org/obo/GO_0051094	positive regulation of developmental process	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
http://purl.obolibrary.org/obo/GO_0051216	cartilage development	http://purl.obolibrary.org/obo/GO_0048513	animal organ development		The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
http://purl.obolibrary.org/obo/GO_0051240	positive regulation of multicellular organismal process	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
http://purl.obolibrary.org/obo/GO_0051252	regulation of RNA metabolic process	http://purl.obolibrary.org/obo/GO_0060255	regulation of macromolecule metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
http://purl.obolibrary.org/obo/GO_0051254	positive regulation of RNA metabolic process	http://purl.obolibrary.org/obo/GO_0051252	regulation of RNA metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.
http://purl.obolibrary.org/obo/GO_0051276	chromosome organization	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
http://purl.obolibrary.org/obo/GO_0051301	cell division	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
http://purl.obolibrary.org/obo/GO_0051302	regulation of cell division	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
http://purl.obolibrary.org/obo/GO_0051319	G2 phase	http://purl.obolibrary.org/obo/GO_0022403	cell cycle phase		The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).
http://purl.obolibrary.org/obo/GO_0051321	meiotic cell cycle	http://purl.obolibrary.org/obo/GO_0022414	reproductive process		Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
http://purl.obolibrary.org/obo/GO_0051493	regulation of cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization		Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
http://purl.obolibrary.org/obo/GO_0051590	positive regulation of neurotransmitter transport	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051608	histamine transport	http://purl.obolibrary.org/obo/GO_0071705	nitrogen compound transport		The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
http://purl.obolibrary.org/obo/GO_0051707	response to other organism	http://purl.obolibrary.org/obo/GO_0044419	biological process involved in interspecies interaction between organisms		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.
http://purl.obolibrary.org/obo/GO_0051726	regulation of cell cycle	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the rate or extent of progression through the cell cycle.
http://purl.obolibrary.org/obo/GO_0051955	regulation of amino acid transport	http://purl.obolibrary.org/obo/GO_0051952	regulation of amine transport		Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051956	negative regulation of amino acid transport	http://purl.obolibrary.org/obo/GO_0051953	negative regulation of amine transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051957	positive regulation of amino acid transport	http://purl.obolibrary.org/obo/GO_0051954	positive regulation of amine transport		Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0055082	intracellular chemical homeostasis	http://purl.obolibrary.org/obo/GO_0048878	chemical homeostasis		A homeostatic process involved in the maintenance of a steady state level of a chemical within a cell.
http://purl.obolibrary.org/obo/GO_0060135	maternal process involved in female pregnancy	http://purl.obolibrary.org/obo/GO_0048609	multicellular organismal reproductive process		A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
http://purl.obolibrary.org/obo/GO_0060249	anatomical structure homeostasis	http://purl.obolibrary.org/obo/GO_0048871	multicellular organismal-level homeostasis		A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
http://purl.obolibrary.org/obo/GO_0060255	regulation of macromolecule metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
http://purl.obolibrary.org/obo/GO_0060350	endochondral bone morphogenesis	http://purl.obolibrary.org/obo/GO_0060349	bone morphogenesis		The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.
http://purl.obolibrary.org/obo/GO_0060351	cartilage development involved in endochondral bone morphogenesis	http://purl.obolibrary.org/obo/GO_0051216	cartilage development		The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.
http://purl.obolibrary.org/obo/GO_0060429	epithelium development	http://purl.obolibrary.org/obo/GO_0009888	tissue development		The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
http://purl.obolibrary.org/obo/GO_0060560	developmental growth involved in morphogenesis	http://purl.obolibrary.org/obo/GO_0048589	developmental growth		The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.
http://purl.obolibrary.org/obo/GO_0060561	apoptotic process involved in morphogenesis	http://purl.obolibrary.org/obo/GO_1902742	apoptotic process involved in development		Any apoptotic process that contributes to the shaping of an anatomical structure.
http://purl.obolibrary.org/obo/GO_0060562	epithelial tube morphogenesis	http://purl.obolibrary.org/obo/GO_0002009	morphogenesis of an epithelium		The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
http://purl.obolibrary.org/obo/GO_0060606	tube closure	http://purl.obolibrary.org/obo/GO_0035148	tube formation		Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold.
http://purl.obolibrary.org/obo/GO_0060632	regulation of microtubule-based movement	http://purl.obolibrary.org/obo/GO_0032886	regulation of microtubule-based process		Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.
http://purl.obolibrary.org/obo/GO_0060759	regulation of response to cytokine stimulus	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus.
http://purl.obolibrary.org/obo/GO_0060760	positive regulation of response to cytokine stimulus	http://purl.obolibrary.org/obo/GO_0060759	regulation of response to cytokine stimulus		Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.
http://purl.obolibrary.org/obo/GO_0060761	negative regulation of response to cytokine stimulus	http://purl.obolibrary.org/obo/GO_0060759	regulation of response to cytokine stimulus		Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus.
http://purl.obolibrary.org/obo/GO_0060841	venous blood vessel development	http://purl.obolibrary.org/obo/GO_0001568	blood vessel development		The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.
http://purl.obolibrary.org/obo/GO_0061025	membrane fusion	http://purl.obolibrary.org/obo/GO_0061024	membrane organization		The membrane organization process that joins two lipid bilayers to form a single membrane.
http://purl.obolibrary.org/obo/GO_0061035	regulation of cartilage development	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
http://purl.obolibrary.org/obo/GO_0061448	connective tissue development	http://purl.obolibrary.org/obo/GO_0009888	tissue development		The progression of a connective tissue over time, from its formation to the mature structure.
http://purl.obolibrary.org/obo/GO_0061695	transferase complex, transferring phosphorus-containing groups	http://purl.obolibrary.org/obo/GO_1990234	transferase complex		A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
http://purl.obolibrary.org/obo/GO_0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	http://purl.obolibrary.org/obo/GO_0019730	antimicrobial humoral response		An immune response against microbes mediated by anti-microbial peptides in body fluid.
http://purl.obolibrary.org/obo/GO_0065008	regulation of biological quality	http://purl.obolibrary.org/obo/GO_0065007	biological regulation		Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
http://purl.obolibrary.org/obo/GO_0070227	lymphocyte apoptotic process	http://purl.obolibrary.org/obo/GO_0071887	leukocyte apoptotic process		Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
http://purl.obolibrary.org/obo/GO_0070228	regulation of lymphocyte apoptotic process	http://purl.obolibrary.org/obo/GO_2000106	regulation of leukocyte apoptotic process		Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.
http://purl.obolibrary.org/obo/GO_0070229	negative regulation of lymphocyte apoptotic process	http://purl.obolibrary.org/obo/GO_2000107	negative regulation of leukocyte apoptotic process		Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.
http://purl.obolibrary.org/obo/GO_0070230	positive regulation of lymphocyte apoptotic process	http://purl.obolibrary.org/obo/GO_2000108	positive regulation of leukocyte apoptotic process		Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.
http://purl.obolibrary.org/obo/GO_0070278	extracellular matrix constituent secretion	http://purl.obolibrary.org/obo/GO_0032940	secretion by cell		The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell.
http://purl.obolibrary.org/obo/GO_0070482	response to oxygen levels	http://purl.obolibrary.org/obo/GO_0009628	response to abiotic stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
http://purl.obolibrary.org/obo/GO_0070483	detection of hypoxia	http://purl.obolibrary.org/obo/GO_0003032	detection of oxygen		The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
http://purl.obolibrary.org/obo/GO_0070586	cell-cell adhesion involved in gastrulation	http://purl.obolibrary.org/obo/GO_0098609	cell-cell adhesion		The attachment of one cell to another cell affecting gastrulation.
http://purl.obolibrary.org/obo/GO_0070661	leukocyte proliferation	http://purl.obolibrary.org/obo/GO_0008283	cell population proliferation		The expansion of a leukocyte population by cell division.
http://purl.obolibrary.org/obo/GO_0070887	cellular response to chemical stimulus	http://purl.obolibrary.org/obo/GO_0042221	response to chemical		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
http://purl.obolibrary.org/obo/GO_0070925	organelle assembly	http://purl.obolibrary.org/obo/GO_0022607	cellular component assembly		The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
http://purl.obolibrary.org/obo/GO_0071621	granulocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0097530	granulocyte migration		The movement of a granulocyte in response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0071674	mononuclear cell migration	http://purl.obolibrary.org/obo/GO_0050900	leukocyte migration		The movement of a mononuclear cell within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_0071695	anatomical structure maturation	http://purl.obolibrary.org/obo/GO_0021700	developmental maturation		A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.
http://purl.obolibrary.org/obo/GO_0071887	leukocyte apoptotic process	http://purl.obolibrary.org/obo/GO_0006915	apoptotic process		Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
http://purl.obolibrary.org/obo/GO_0072001	renal system development	http://purl.obolibrary.org/obo/GO_0048731	system development		The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.
http://purl.obolibrary.org/obo/GO_0072175	epithelial tube formation	http://purl.obolibrary.org/obo/GO_0035148	tube formation		The developmental process pertaining to the initial formation of an epithelial tube.
http://purl.obolibrary.org/obo/GO_0072330	monocarboxylic acid biosynthetic process	http://purl.obolibrary.org/obo/GO_0046394	carboxylic acid biosynthetic process		The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.
http://purl.obolibrary.org/obo/GO_0072350	tricarboxylic acid metabolic process	http://purl.obolibrary.org/obo/GO_0019752	carboxylic acid metabolic process		The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).
http://purl.obolibrary.org/obo/GO_0072376	protein activation cascade	http://purl.obolibrary.org/obo/GO_0051604	protein maturation		A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events.
http://purl.obolibrary.org/obo/GO_0072593	reactive oxygen species metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
http://purl.obolibrary.org/obo/GO_0080135	regulation of cellular response to stress	http://purl.obolibrary.org/obo/GO_0080134	regulation of response to stress		Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
http://purl.obolibrary.org/obo/GO_0090087	regulation of peptide transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0090174	organelle membrane fusion	http://purl.obolibrary.org/obo/GO_0061025	membrane fusion		The joining of two lipid bilayers to form a single organelle membrane.
http://purl.obolibrary.org/obo/GO_0090594	inflammatory response to wounding	http://purl.obolibrary.org/obo/GO_0009611	response to wounding		The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.
http://purl.obolibrary.org/obo/GO_0090715	immunological memory formation process	http://purl.obolibrary.org/obo/GO_0090713	immunological memory process		Any immunological memory process that can contribute to the formation of immunological memory.
http://purl.obolibrary.org/obo/GO_0097028	dendritic cell differentiation	http://purl.obolibrary.org/obo/GO_1903131	mononuclear cell differentiation		The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
http://purl.obolibrary.org/obo/GO_0097190	apoptotic signaling pathway	http://purl.obolibrary.org/obo/GO_0007165	signal transduction		The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
http://purl.obolibrary.org/obo/GO_0097205	renal filtration	http://purl.obolibrary.org/obo/GO_0003014	renal system process		A renal system process in which fluid circulating through the body is filtered through a barrier system.
http://purl.obolibrary.org/obo/GO_0097529	myeloid leukocyte migration	http://purl.obolibrary.org/obo/GO_0050900	leukocyte migration		The movement of a myeloid leukocyte within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_0098542	defense response to other organism	http://purl.obolibrary.org/obo/GO_0051707	response to other organism		Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
http://purl.obolibrary.org/obo/GO_0098588	bounding membrane of organelle	http://purl.obolibrary.org/obo/GO_0031090	organelle membrane		The lipid bilayer that forms the outer-most layer of an organelle.
http://purl.obolibrary.org/obo/GO_0098657	import into cell	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
http://purl.obolibrary.org/obo/GO_0098796	membrane protein complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		Any protein complex that is part of a membrane.
http://purl.obolibrary.org/obo/GO_0098797	plasma membrane protein complex	http://purl.obolibrary.org/obo/GO_0098796	membrane protein complex		Any protein complex that is part of the plasma membrane.
http://purl.obolibrary.org/obo/GO_0098801	regulation of renal system process	http://purl.obolibrary.org/obo/GO_0044057	regulation of system process		Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system.
http://purl.obolibrary.org/obo/GO_0098813	nuclear chromosome segregation	http://purl.obolibrary.org/obo/GO_0007059	chromosome segregation		The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
http://purl.obolibrary.org/obo/GO_0099512	supramolecular fiber	http://purl.obolibrary.org/obo/GO_0099081	supramolecular polymer		A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
http://purl.obolibrary.org/obo/GO_0099513	polymeric cytoskeletal fiber	http://purl.obolibrary.org/obo/GO_0099512	supramolecular fiber		A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.
http://purl.obolibrary.org/obo/GO_1900424	regulation of defense response to bacterium	http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response		Any process that modulates the frequency, rate or extent of defense response to bacterium.
http://purl.obolibrary.org/obo/GO_1900425	negative regulation of defense response to bacterium	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.
http://purl.obolibrary.org/obo/GO_1900426	positive regulation of defense response to bacterium	http://purl.obolibrary.org/obo/GO_1900424	regulation of defense response to bacterium		Any process that activates or increases the frequency, rate or extent of defense response to bacterium.
http://purl.obolibrary.org/obo/GO_1901700	response to oxygen-containing compound	http://purl.obolibrary.org/obo/GO_0042221	response to chemical		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.
http://purl.obolibrary.org/obo/GO_1902105	regulation of leukocyte differentiation	http://purl.obolibrary.org/obo/GO_1903706	regulation of hemopoiesis		Any process that modulates the frequency, rate or extent of leukocyte differentiation.
http://purl.obolibrary.org/obo/GO_1902106	negative regulation of leukocyte differentiation	http://purl.obolibrary.org/obo/GO_1903707	negative regulation of hemopoiesis		Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.
http://purl.obolibrary.org/obo/GO_1902107	positive regulation of leukocyte differentiation	http://purl.obolibrary.org/obo/GO_1903708	positive regulation of hemopoiesis		Any process that activates or increases the frequency, rate or extent of leukocyte differentiation.
http://purl.obolibrary.org/obo/GO_1902494	catalytic complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A protein complex which is capable of catalytic activity.
http://purl.obolibrary.org/obo/GO_1902742	apoptotic process involved in development	http://purl.obolibrary.org/obo/GO_0006915	apoptotic process		Any apoptotic process that is involved in anatomical structure development.
http://purl.obolibrary.org/obo/GO_1903010	regulation of bone development	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of bone development.
http://purl.obolibrary.org/obo/GO_1903046	meiotic cell cycle process	http://purl.obolibrary.org/obo/GO_0022414	reproductive process		A process that is part of the meiotic cell cycle.
http://purl.obolibrary.org/obo/GO_1903047	mitotic cell cycle process	http://purl.obolibrary.org/obo/GO_0022402	cell cycle process		A process that is part of the mitotic cell cycle.
http://purl.obolibrary.org/obo/GO_1903053	regulation of extracellular matrix organization	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of extracellular matrix organization.
http://purl.obolibrary.org/obo/GO_1903054	negative regulation of extracellular matrix organization	http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization		Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.
http://purl.obolibrary.org/obo/GO_1903055	positive regulation of extracellular matrix organization	http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization		Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.
http://purl.obolibrary.org/obo/GO_1903530	regulation of secretion by cell	http://purl.obolibrary.org/obo/GO_0051046	regulation of secretion		Any process that modulates the frequency, rate or extent of secretion by cell.
http://purl.obolibrary.org/obo/GO_1903531	negative regulation of secretion by cell	http://purl.obolibrary.org/obo/GO_1903530	regulation of secretion by cell		Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.
http://purl.obolibrary.org/obo/GO_1903532	positive regulation of secretion by cell	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of secretion by cell.
http://purl.obolibrary.org/obo/GO_1904746	negative regulation of apoptotic process involved in development	http://purl.obolibrary.org/obo/GO_1904748	regulation of apoptotic process involved in development		Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development.
http://purl.obolibrary.org/obo/GO_1904747	positive regulation of apoptotic process involved in development	http://purl.obolibrary.org/obo/GO_0043065	positive regulation of apoptotic process		Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.
http://purl.obolibrary.org/obo/GO_1904748	regulation of apoptotic process involved in development	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of apoptotic process involved in development.
http://purl.obolibrary.org/obo/GO_1905330	regulation of morphogenesis of an epithelium	http://purl.obolibrary.org/obo/GO_0022603	regulation of anatomical structure morphogenesis		Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium.
http://purl.obolibrary.org/obo/GO_1905331	negative regulation of morphogenesis of an epithelium	http://purl.obolibrary.org/obo/GO_1905330	regulation of morphogenesis of an epithelium		Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium.
http://purl.obolibrary.org/obo/GO_1990234	transferase complex	http://purl.obolibrary.org/obo/GO_1902494	catalytic complex		A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of multicellular organismal development.
http://purl.obolibrary.org/obo/GO_2000027	regulation of animal organ morphogenesis	http://purl.obolibrary.org/obo/GO_0022603	regulation of anatomical structure morphogenesis		Any process that modulates the frequency, rate or extent of animal organ morphogenesis.
http://purl.obolibrary.org/obo/GO_2000257	regulation of protein activation cascade	http://purl.obolibrary.org/obo/GO_1903317	regulation of protein maturation		Any process that modulates the frequency, rate or extent of protein activation cascade.
http://purl.obolibrary.org/obo/GO_2000258	negative regulation of protein activation cascade	http://purl.obolibrary.org/obo/GO_1903318	negative regulation of protein maturation		Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade.
http://purl.obolibrary.org/obo/GO_2000259	positive regulation of protein activation cascade	http://purl.obolibrary.org/obo/GO_1903319	positive regulation of protein maturation		Any process that activates or increases the frequency, rate or extent of protein activation cascade.
http://purl.obolibrary.org/obo/GO_2000858	regulation of aldosterone secretion	http://purl.obolibrary.org/obo/GO_2000855	regulation of mineralocorticoid secretion		Any process that modulates the frequency, rate or extent of aldosterone secretion.
http://purl.obolibrary.org/obo/GO_0019172	glyoxalase III activity	http://purl.obolibrary.org/obo/GO_0016836	hydro-lyase activity		Catalysis of the reaction: methylglyoxal + H2O = D-lactate.
http://purl.obolibrary.org/obo/GO_0019216	regulation of lipid metabolic process	http://purl.obolibrary.org/obo/GO_0080090	regulation of primary metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
http://purl.obolibrary.org/obo/GO_0019226	transmission of nerve impulse	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.
http://purl.obolibrary.org/obo/GO_0019230	proprioception	http://purl.obolibrary.org/obo/GO_0007600	sensory perception		The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors.
http://purl.obolibrary.org/obo/GO_0019233	sensory perception of pain	http://purl.obolibrary.org/obo/GO_0007600	sensory perception		The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. A painful stimulus is any physical or chemical event that has the potential to cause tissue damage (actual or perceived) and activates the nociceptive system.
http://purl.obolibrary.org/obo/GO_0019814	immunoglobulin complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0019815	B cell receptor complex	http://purl.obolibrary.org/obo/GO_0019814	immunoglobulin complex		An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
http://purl.obolibrary.org/obo/GO_0019852	L-ascorbic acid metabolic process	http://purl.obolibrary.org/obo/GO_1901334	lactone metabolic process		The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
http://purl.obolibrary.org/obo/GO_0022008	neurogenesis	http://purl.obolibrary.org/obo/GO_0030154	cell differentiation		Generation of cells within the nervous system.
http://purl.obolibrary.org/obo/GO_0022010	central nervous system myelination	http://purl.obolibrary.org/obo/GO_0042552	myelination		The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
http://purl.obolibrary.org/obo/GO_0022011	myelination in peripheral nervous system	http://purl.obolibrary.org/obo/GO_0042552	myelination		The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
http://purl.obolibrary.org/obo/GO_0022407	regulation of cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0030155	regulation of cell adhesion		Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.
http://purl.obolibrary.org/obo/GO_0022408	negative regulation of cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0022407	regulation of cell-cell adhesion		Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
http://purl.obolibrary.org/obo/GO_0022409	positive regulation of cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0045785	positive regulation of cell adhesion		Any process that activates or increases the rate or extent of cell adhesion to another cell.
http://purl.obolibrary.org/obo/GO_0022410	circadian sleep/wake cycle process	http://purl.obolibrary.org/obo/GO_0048512	circadian behavior		A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
http://purl.obolibrary.org/obo/GO_0022601	menstrual cycle phase	http://purl.obolibrary.org/obo/GO_0044848	biological phase		The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.
http://purl.obolibrary.org/obo/GO_0022613	ribonucleoprotein complex biogenesis	http://purl.obolibrary.org/obo/GO_0044085	cellular component biogenesis		A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.
http://purl.obolibrary.org/obo/GO_0022898	regulation of transmembrane transporter activity	http://purl.obolibrary.org/obo/GO_0065009	regulation of molecular function		Any process that modulates the frequency, rate or extent of transmembrane transporter activity.
http://purl.obolibrary.org/obo/GO_0023019	signal transduction involved in regulation of gene expression	http://purl.obolibrary.org/obo/GO_0007165	signal transduction		Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
http://purl.obolibrary.org/obo/GO_0023052	signaling	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
http://purl.obolibrary.org/obo/GO_0023061	signal release	http://purl.obolibrary.org/obo/GO_0032940	secretion by cell		The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.
http://purl.obolibrary.org/obo/GO_0030016	myofibril	http://purl.obolibrary.org/obo/GO_0043292	contractile muscle fiber		The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
http://purl.obolibrary.org/obo/GO_0030030	cell projection organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
http://purl.obolibrary.org/obo/GO_0030057	desmosome	http://purl.obolibrary.org/obo/GO_0005911	cell-cell junction		A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion	http://purl.obolibrary.org/obo/GO_0046879	hormone secretion		The regulated release of a peptide hormone from a cell.
http://purl.obolibrary.org/obo/GO_0030073	insulin secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
http://purl.obolibrary.org/obo/GO_0030100	regulation of endocytosis	http://purl.obolibrary.org/obo/GO_0060627	regulation of vesicle-mediated transport		Any process that modulates the frequency, rate or extent of endocytosis.
http://purl.obolibrary.org/obo/GO_0030162	regulation of proteolysis	http://purl.obolibrary.org/obo/GO_0051246	regulation of protein metabolic process		Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
http://purl.obolibrary.org/obo/GO_0030186	melatonin metabolic process	http://purl.obolibrary.org/obo/GO_0042445	hormone metabolic process		The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine).
http://purl.obolibrary.org/obo/GO_0030187	melatonin biosynthetic process	http://purl.obolibrary.org/obo/GO_0042435	indole-containing compound biosynthetic process		The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine).
http://purl.obolibrary.org/obo/GO_0030202	heparin proteoglycan metabolic process	http://purl.obolibrary.org/obo/GO_0006029	proteoglycan metabolic process		The chemical reactions and pathways involving heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin proteoglycans are stored selectively in the secretory granules of mammalian mast cells.
http://purl.obolibrary.org/obo/GO_0030210	heparin proteoglycan biosynthetic process	http://purl.obolibrary.org/obo/GO_0180064	protein O-linked glycosylation via xylose		The chemical reactions and pathways resulting in the formation of heparin proteoglycans, which consist of a core protein linked to a heparin glycosaminoglycan. The heparin chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparin is similar to heparan sulfate but it contains more N-sulfate and O-sulfate groups. Heparin chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).
http://purl.obolibrary.org/obo/GO_0030218	erythrocyte differentiation	http://purl.obolibrary.org/obo/GO_0030099	myeloid cell differentiation		The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
http://purl.obolibrary.org/obo/GO_0030219	megakaryocyte differentiation	http://purl.obolibrary.org/obo/GO_0030099	myeloid cell differentiation		The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.
http://purl.obolibrary.org/obo/GO_0030221	basophil differentiation	http://purl.obolibrary.org/obo/GO_0030851	granulocyte differentiation		The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.
http://purl.obolibrary.org/obo/GO_0030224	monocyte differentiation	http://purl.obolibrary.org/obo/GO_1903131	mononuclear cell differentiation		The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.
http://purl.obolibrary.org/obo/GO_0030252	growth hormone secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of growth hormone from secretory granules into the blood.
http://purl.obolibrary.org/obo/GO_0030263	apoptotic chromosome condensation	http://purl.obolibrary.org/obo/GO_0030261	chromosome condensation		The compaction of chromatin during apoptosis.
http://purl.obolibrary.org/obo/GO_0030278	regulation of ossification	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
http://purl.obolibrary.org/obo/GO_0030279	negative regulation of ossification	http://purl.obolibrary.org/obo/GO_0030278	regulation of ossification		Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
http://purl.obolibrary.org/obo/GO_0030282	bone mineralization	http://purl.obolibrary.org/obo/GO_0031214	biomineral tissue development		The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
http://purl.obolibrary.org/obo/GO_0030307	positive regulation of cell growth	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate, extent or direction of cell growth.
http://purl.obolibrary.org/obo/GO_0030308	negative regulation of cell growth	http://purl.obolibrary.org/obo/GO_0045926	negative regulation of growth		Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
http://purl.obolibrary.org/obo/GO_0030316	osteoclast differentiation	http://purl.obolibrary.org/obo/GO_0002573	myeloid leukocyte differentiation		The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
http://purl.obolibrary.org/obo/GO_0030323	respiratory tube development	http://purl.obolibrary.org/obo/GO_0048513	animal organ development		The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.
http://purl.obolibrary.org/obo/GO_0030324	lung development	http://purl.obolibrary.org/obo/GO_0048513	animal organ development		The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
http://purl.obolibrary.org/obo/GO_0030421	defecation	http://purl.obolibrary.org/obo/GO_0022600	digestive system process		The expulsion of feces from the rectum.
http://purl.obolibrary.org/obo/GO_0030424	axon	http://purl.obolibrary.org/obo/GO_0043005	neuron projection		The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
http://purl.obolibrary.org/obo/GO_0030425	dendrite	http://purl.obolibrary.org/obo/GO_0043005	neuron projection		A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
http://purl.obolibrary.org/obo/GO_0030431	sleep	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
http://purl.obolibrary.org/obo/GO_0030432	peristalsis	http://purl.obolibrary.org/obo/GO_0014821	phasic smooth muscle contraction		A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.
http://purl.obolibrary.org/obo/GO_0030500	regulation of bone mineralization	http://purl.obolibrary.org/obo/GO_0070167	regulation of biomineral tissue development		Any process that modulates the frequency, rate or extent of bone mineralization.
http://purl.obolibrary.org/obo/GO_0030501	positive regulation of bone mineralization	http://purl.obolibrary.org/obo/GO_0070169	positive regulation of biomineral tissue development		Any process that activates or increases the frequency, rate or extent of bone mineralization.
http://purl.obolibrary.org/obo/GO_0030502	negative regulation of bone mineralization	http://purl.obolibrary.org/obo/GO_0070168	negative regulation of biomineral tissue development		Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
http://purl.obolibrary.org/obo/GO_0030593	neutrophil chemotaxis	http://purl.obolibrary.org/obo/GO_1990266	neutrophil migration		The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
http://purl.obolibrary.org/obo/GO_0030656	regulation of vitamin metabolic process	http://purl.obolibrary.org/obo/GO_0062012	regulation of small molecule metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
http://purl.obolibrary.org/obo/GO_0030659	cytoplasmic vesicle membrane	http://purl.obolibrary.org/obo/GO_0012506	vesicle membrane		The lipid bilayer surrounding a cytoplasmic vesicle.
http://purl.obolibrary.org/obo/GO_0030851	granulocyte differentiation	http://purl.obolibrary.org/obo/GO_0002573	myeloid leukocyte differentiation		The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
http://purl.obolibrary.org/obo/GO_0030852	regulation of granulocyte differentiation	http://purl.obolibrary.org/obo/GO_0002761	regulation of myeloid leukocyte differentiation		Any process that modulates the frequency, rate or extent of granulocyte differentiation.
http://purl.obolibrary.org/obo/GO_0030853	negative regulation of granulocyte differentiation	http://purl.obolibrary.org/obo/GO_0030852	regulation of granulocyte differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.
http://purl.obolibrary.org/obo/GO_0030854	positive regulation of granulocyte differentiation	http://purl.obolibrary.org/obo/GO_0030852	regulation of granulocyte differentiation		Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.
http://purl.obolibrary.org/obo/GO_0030856	regulation of epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0045595	regulation of cell differentiation		Any process that modulates the frequency, rate or extent of epithelial cell differentiation.
http://purl.obolibrary.org/obo/GO_0030858	positive regulation of epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0045597	positive regulation of cell differentiation		Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.
http://purl.obolibrary.org/obo/GO_0030885	regulation of myeloid dendritic cell activation	http://purl.obolibrary.org/obo/GO_0002694	regulation of leukocyte activation		Any process that modulates the frequency or rate of myeloid dendritic cell activation.
http://purl.obolibrary.org/obo/GO_0030886	negative regulation of myeloid dendritic cell activation	http://purl.obolibrary.org/obo/GO_0030885	regulation of myeloid dendritic cell activation		Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.
http://purl.obolibrary.org/obo/GO_0030887	positive regulation of myeloid dendritic cell activation	http://purl.obolibrary.org/obo/GO_0030885	regulation of myeloid dendritic cell activation		Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.
http://purl.obolibrary.org/obo/GO_0030888	regulation of B cell proliferation	http://purl.obolibrary.org/obo/GO_0050864	regulation of B cell activation		Any process that modulates the frequency, rate or extent of B cell proliferation.
http://purl.obolibrary.org/obo/GO_0030889	negative regulation of B cell proliferation	http://purl.obolibrary.org/obo/GO_0050869	negative regulation of B cell activation		Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
http://purl.obolibrary.org/obo/GO_0030890	positive regulation of B cell proliferation	http://purl.obolibrary.org/obo/GO_0050871	positive regulation of B cell activation		Any process that activates or increases the rate or extent of B cell proliferation.
http://purl.obolibrary.org/obo/GO_0031023	microtubule organizing center organization	http://purl.obolibrary.org/obo/GO_0007017	microtubule-based process		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.
http://purl.obolibrary.org/obo/GO_0031045	dense core granule	http://purl.obolibrary.org/obo/GO_0030141	secretory granule		Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.
http://purl.obolibrary.org/obo/GO_0031049	programmed DNA elimination	http://purl.obolibrary.org/obo/GO_0010629	negative regulation of gene expression		A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing.
http://purl.obolibrary.org/obo/GO_0031052	programmed DNA elimination by chromosome breakage	http://purl.obolibrary.org/obo/GO_0031049	programmed DNA elimination		Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.
http://purl.obolibrary.org/obo/GO_0031099	regeneration	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).
http://purl.obolibrary.org/obo/GO_0031201	SNARE complex	http://purl.obolibrary.org/obo/GO_0098796	membrane protein complex		A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
http://purl.obolibrary.org/obo/GO_0031214	biomineral tissue development	http://purl.obolibrary.org/obo/GO_0009888	tissue development		Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.
http://purl.obolibrary.org/obo/GO_0031268	pseudopodium organization	http://purl.obolibrary.org/obo/GO_0120036	plasma membrane bounded cell projection organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.
http://purl.obolibrary.org/obo/GO_0031338	regulation of vesicle fusion	http://purl.obolibrary.org/obo/GO_0060627	regulation of vesicle-mediated transport		Any process that modulates the frequency, rate or extent of vesicle fusion.
http://purl.obolibrary.org/obo/GO_0031339	negative regulation of vesicle fusion	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.
http://purl.obolibrary.org/obo/GO_0031340	positive regulation of vesicle fusion	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of vesicle fusion.
http://purl.obolibrary.org/obo/GO_0031424	keratinization	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.
http://purl.obolibrary.org/obo/GO_0031594	neuromuscular junction	http://purl.obolibrary.org/obo/GO_0045202	synapse		The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
http://purl.obolibrary.org/obo/GO_0031641	regulation of myelination	http://purl.obolibrary.org/obo/GO_0051960	regulation of nervous system development		Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
http://purl.obolibrary.org/obo/GO_0031642	negative regulation of myelination	http://purl.obolibrary.org/obo/GO_0031645	negative regulation of nervous system process		Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
http://purl.obolibrary.org/obo/GO_0031643	positive regulation of myelination	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
http://purl.obolibrary.org/obo/GO_0031644	regulation of nervous system process	http://purl.obolibrary.org/obo/GO_0044057	regulation of system process		Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
http://purl.obolibrary.org/obo/GO_0031645	negative regulation of nervous system process	http://purl.obolibrary.org/obo/GO_0031644	regulation of nervous system process		Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.
http://purl.obolibrary.org/obo/GO_0031646	positive regulation of nervous system process	http://purl.obolibrary.org/obo/GO_0031644	regulation of nervous system process		Any process that activates or increases the frequency, rate or extent of a neurophysiological process.
http://purl.obolibrary.org/obo/GO_0031943	regulation of glucocorticoid metabolic process	http://purl.obolibrary.org/obo/GO_0032350	regulation of hormone metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.
http://purl.obolibrary.org/obo/GO_0031946	regulation of glucocorticoid biosynthetic process	http://purl.obolibrary.org/obo/GO_0031943	regulation of glucocorticoid metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.
http://purl.obolibrary.org/obo/GO_0031947	negative regulation of glucocorticoid biosynthetic process	http://purl.obolibrary.org/obo/GO_0090032	negative regulation of steroid hormone biosynthetic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.
http://purl.obolibrary.org/obo/GO_0031948	positive regulation of glucocorticoid biosynthetic process	http://purl.obolibrary.org/obo/GO_0090031	positive regulation of steroid hormone biosynthetic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.
http://purl.obolibrary.org/obo/GO_0031987	locomotion involved in locomotory behavior	http://purl.obolibrary.org/obo/GO_0040011	locomotion		Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
http://purl.obolibrary.org/obo/GO_0032024	positive regulation of insulin secretion	http://purl.obolibrary.org/obo/GO_0090277	positive regulation of peptide hormone secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
http://purl.obolibrary.org/obo/GO_0032055	negative regulation of translation in response to stress	http://purl.obolibrary.org/obo/GO_0043555	regulation of translation in response to stress		Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.
http://purl.obolibrary.org/obo/GO_0032057	negative regulation of translational initiation in response to stress	http://purl.obolibrary.org/obo/GO_0045947	negative regulation of translational initiation		Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.
http://purl.obolibrary.org/obo/GO_0032058	positive regulation of translational initiation in response to stress	http://purl.obolibrary.org/obo/GO_0045948	positive regulation of translational initiation		Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.
http://purl.obolibrary.org/obo/GO_0032060	bleb assembly	http://purl.obolibrary.org/obo/GO_0120031	plasma membrane bounded cell projection assembly		The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
http://purl.obolibrary.org/obo/GO_0032098	regulation of appetite	http://purl.obolibrary.org/obo/GO_0065008	regulation of biological quality		Any process which modulates appetite, the desire or physical craving for food.
http://purl.obolibrary.org/obo/GO_0032107	regulation of response to nutrient levels	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that modulates the frequency, rate or extent of a response to nutrient levels.
http://purl.obolibrary.org/obo/GO_0032109	positive regulation of response to nutrient levels	http://purl.obolibrary.org/obo/GO_0032107	regulation of response to nutrient levels		Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.
http://purl.obolibrary.org/obo/GO_0032228	regulation of synaptic transmission, GABAergic	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
http://purl.obolibrary.org/obo/GO_0032229	negative regulation of synaptic transmission, GABAergic	http://purl.obolibrary.org/obo/GO_0050805	negative regulation of synaptic transmission		Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
http://purl.obolibrary.org/obo/GO_0032230	positive regulation of synaptic transmission, GABAergic	http://purl.obolibrary.org/obo/GO_0032228	regulation of synaptic transmission, GABAergic		Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
http://purl.obolibrary.org/obo/GO_0032274	gonadotropin secretion	http://purl.obolibrary.org/obo/GO_0046879	hormone secretion		The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone.
http://purl.obolibrary.org/obo/GO_0032275	luteinizing hormone secretion	http://purl.obolibrary.org/obo/GO_0032274	gonadotropin secretion		The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.
http://purl.obolibrary.org/obo/GO_0032276	regulation of gonadotropin secretion	http://purl.obolibrary.org/obo/GO_0046883	regulation of hormone secretion		Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin.
http://purl.obolibrary.org/obo/GO_0032277	negative regulation of gonadotropin secretion	http://purl.obolibrary.org/obo/GO_0046888	negative regulation of hormone secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin.
http://purl.obolibrary.org/obo/GO_0032278	positive regulation of gonadotropin secretion	http://purl.obolibrary.org/obo/GO_0046887	positive regulation of hormone secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin.
http://purl.obolibrary.org/obo/GO_0032286	central nervous system myelin maintenance	http://purl.obolibrary.org/obo/GO_0043217	myelin maintenance		The process in which the structure and material content of mature central nervous system myelin is kept in a functional state.
http://purl.obolibrary.org/obo/GO_0032288	myelin assembly	http://purl.obolibrary.org/obo/GO_0010927	cellular component assembly involved in morphogenesis		The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.
http://purl.obolibrary.org/obo/GO_0032289	central nervous system myelin formation	http://purl.obolibrary.org/obo/GO_0032288	myelin assembly		The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
http://purl.obolibrary.org/obo/GO_0032291	axon ensheathment in central nervous system	http://purl.obolibrary.org/obo/GO_0008366	axon ensheathment		The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.
http://purl.obolibrary.org/obo/GO_0032292	peripheral nervous system axon ensheathment	http://purl.obolibrary.org/obo/GO_0008366	axon ensheathment		The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.
http://purl.obolibrary.org/obo/GO_0032351	negative regulation of hormone metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone.
http://purl.obolibrary.org/obo/GO_0032352	positive regulation of hormone metabolic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone.
http://purl.obolibrary.org/obo/GO_0032353	negative regulation of hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0009890	negative regulation of biosynthetic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
http://purl.obolibrary.org/obo/GO_0032369	negative regulation of lipid transport	http://purl.obolibrary.org/obo/GO_1905953	negative regulation of lipid localization		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0032370	positive regulation of lipid transport	http://purl.obolibrary.org/obo/GO_1905954	positive regulation of lipid localization		Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0032386	regulation of intracellular transport	http://purl.obolibrary.org/obo/GO_0060341	regulation of cellular localization		Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.
http://purl.obolibrary.org/obo/GO_0032387	negative regulation of intracellular transport	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.
http://purl.obolibrary.org/obo/GO_0032388	positive regulation of intracellular transport	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.
http://purl.obolibrary.org/obo/GO_0032410	negative regulation of transporter activity	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops or reduces the activity of a transporter.
http://purl.obolibrary.org/obo/GO_0032411	positive regulation of transporter activity	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the activity of a transporter.
http://purl.obolibrary.org/obo/GO_0032543	mitochondrial translation	http://purl.obolibrary.org/obo/GO_0006412	translation		The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
http://purl.obolibrary.org/obo/GO_0032594	protein transport within lipid bilayer	http://purl.obolibrary.org/obo/GO_0006886	intracellular protein transport		The directed movement of a protein from one location to another within a lipid bilayer.
http://purl.obolibrary.org/obo/GO_0032602	chemokine production	http://purl.obolibrary.org/obo/GO_0001816	cytokine production		The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
http://purl.obolibrary.org/obo/GO_0032609	type II interferon production	http://purl.obolibrary.org/obo/GO_0001816	cytokine production		The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
http://purl.obolibrary.org/obo/GO_0032642	regulation of chemokine production	http://purl.obolibrary.org/obo/GO_0001817	regulation of cytokine production		Any process that modulates the frequency, rate, or extent of chemokine production.
http://purl.obolibrary.org/obo/GO_0032649	regulation of type II interferon production	http://purl.obolibrary.org/obo/GO_0001817	regulation of cytokine production		Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
http://purl.obolibrary.org/obo/GO_0032682	negative regulation of chemokine production	http://purl.obolibrary.org/obo/GO_0032642	regulation of chemokine production		Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production.
http://purl.obolibrary.org/obo/GO_0032689	negative regulation of type II interferon production	http://purl.obolibrary.org/obo/GO_0032649	regulation of type II interferon production		Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
http://purl.obolibrary.org/obo/GO_0032722	positive regulation of chemokine production	http://purl.obolibrary.org/obo/GO_0032642	regulation of chemokine production		Any process that activates or increases the frequency, rate, or extent of chemokine production.
http://purl.obolibrary.org/obo/GO_0032729	positive regulation of type II interferon production	http://purl.obolibrary.org/obo/GO_0032649	regulation of type II interferon production		Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
http://purl.obolibrary.org/obo/GO_0032811	negative regulation of epinephrine secretion	http://purl.obolibrary.org/obo/GO_0033604	negative regulation of catecholamine secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine.
http://purl.obolibrary.org/obo/GO_0032812	positive regulation of epinephrine secretion	http://purl.obolibrary.org/obo/GO_0033605	positive regulation of catecholamine secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.
http://purl.obolibrary.org/obo/GO_0032839	dendrite cytoplasm	http://purl.obolibrary.org/obo/GO_0120111	neuron projection cytoplasm		All of the contents of a dendrite, excluding the surrounding plasma membrane.
http://purl.obolibrary.org/obo/GO_0032880	regulation of protein localization	http://purl.obolibrary.org/obo/GO_0032879	regulation of localization		Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
http://purl.obolibrary.org/obo/GO_0032881	regulation of polysaccharide metabolic process	http://purl.obolibrary.org/obo/GO_0060255	regulation of macromolecule metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.
http://purl.obolibrary.org/obo/GO_0032886	regulation of microtubule-based process	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.
http://purl.obolibrary.org/obo/GO_0032890	regulation of organic acid transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0032891	negative regulation of organic acid transport	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0032892	positive regulation of organic acid transport	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0032941	secretion by tissue	http://purl.obolibrary.org/obo/GO_0046903	secretion		The controlled release of a substance by a tissue.
http://purl.obolibrary.org/obo/GO_0032943	mononuclear cell proliferation	http://purl.obolibrary.org/obo/GO_0070661	leukocyte proliferation		The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.
http://purl.obolibrary.org/obo/GO_0032944	regulation of mononuclear cell proliferation	http://purl.obolibrary.org/obo/GO_0070663	regulation of leukocyte proliferation		Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.
http://purl.obolibrary.org/obo/GO_0032945	negative regulation of mononuclear cell proliferation	http://purl.obolibrary.org/obo/GO_0070664	negative regulation of leukocyte proliferation		Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.
http://purl.obolibrary.org/obo/GO_0032946	positive regulation of mononuclear cell proliferation	http://purl.obolibrary.org/obo/GO_0070665	positive regulation of leukocyte proliferation		Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.
http://purl.obolibrary.org/obo/GO_0032994	protein-lipid complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other.
http://purl.obolibrary.org/obo/GO_0032997	Fc receptor complex	http://purl.obolibrary.org/obo/GO_0098797	plasma membrane protein complex		A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.
http://purl.obolibrary.org/obo/GO_0033001	Fc-gamma receptor III complex	http://purl.obolibrary.org/obo/GO_0032997	Fc receptor complex		A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.
http://purl.obolibrary.org/obo/GO_0033044	regulation of chromosome organization	http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization		Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
http://purl.obolibrary.org/obo/GO_0033046	negative regulation of sister chromatid segregation	http://purl.obolibrary.org/obo/GO_2001251	negative regulation of chromosome organization		Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.
http://purl.obolibrary.org/obo/GO_0033048	negative regulation of mitotic sister chromatid segregation	http://purl.obolibrary.org/obo/GO_0033047	regulation of mitotic sister chromatid segregation		Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.
http://purl.obolibrary.org/obo/GO_0033151	V(D)J recombination	http://purl.obolibrary.org/obo/GO_0002562	somatic diversification of immune receptors via germline recombination within a single locus		The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
http://purl.obolibrary.org/obo/GO_0033152	immunoglobulin V(D)J recombination	http://purl.obolibrary.org/obo/GO_0033151	V(D)J recombination		The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.
http://purl.obolibrary.org/obo/GO_0033157	regulation of intracellular protein transport	http://purl.obolibrary.org/obo/GO_0051223	regulation of protein transport		Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
http://purl.obolibrary.org/obo/GO_0033365	protein localization to organelle	http://purl.obolibrary.org/obo/GO_0008104	intracellular protein localization		A process in which a protein is transported to, or maintained in, a location within an organelle.
http://purl.obolibrary.org/obo/GO_0033500	carbohydrate homeostasis	http://purl.obolibrary.org/obo/GO_0048878	chemical homeostasis		A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.
http://purl.obolibrary.org/obo/GO_0033684	regulation of luteinizing hormone secretion	http://purl.obolibrary.org/obo/GO_0032276	regulation of gonadotropin secretion		Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone.
http://purl.obolibrary.org/obo/GO_0033685	negative regulation of luteinizing hormone secretion	http://purl.obolibrary.org/obo/GO_0033684	regulation of luteinizing hormone secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone.
http://purl.obolibrary.org/obo/GO_0033686	positive regulation of luteinizing hormone secretion	http://purl.obolibrary.org/obo/GO_0033684	regulation of luteinizing hormone secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone.
http://purl.obolibrary.org/obo/GO_0034097	response to cytokine	http://purl.obolibrary.org/obo/GO_1901652	response to peptide		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
http://purl.obolibrary.org/obo/GO_0034101	erythrocyte homeostasis	http://purl.obolibrary.org/obo/GO_0002262	myeloid cell homeostasis		Any process of regulating the production and elimination of erythrocytes within an organism.
http://purl.obolibrary.org/obo/GO_0034103	regulation of tissue remodeling	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate, or extent of tissue remodeling.
http://purl.obolibrary.org/obo/GO_0034104	negative regulation of tissue remodeling	http://purl.obolibrary.org/obo/GO_0034103	regulation of tissue remodeling		Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling.
http://purl.obolibrary.org/obo/GO_0034105	positive regulation of tissue remodeling	http://purl.obolibrary.org/obo/GO_0034103	regulation of tissue remodeling		Any process that activates or increases the frequency, rate, or extent of tissue remodeling.
http://purl.obolibrary.org/obo/GO_0034110	regulation of homotypic cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0022407	regulation of cell-cell adhesion		Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion.
http://purl.obolibrary.org/obo/GO_0034111	negative regulation of homotypic cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0034110	regulation of homotypic cell-cell adhesion		Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion.
http://purl.obolibrary.org/obo/GO_0034112	positive regulation of homotypic cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0034110	regulation of homotypic cell-cell adhesion		Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion.
http://purl.obolibrary.org/obo/GO_0034242	negative regulation of syncytium formation by plasma membrane fusion	http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization		Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
http://purl.obolibrary.org/obo/GO_0034762	regulation of transmembrane transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0034766	negative regulation of monoatomic ion transmembrane transport	http://purl.obolibrary.org/obo/GO_0043271	negative regulation of monoatomic ion transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0034767	positive regulation of monoatomic ion transmembrane transport	http://purl.obolibrary.org/obo/GO_0043270	positive regulation of monoatomic ion transport		Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0036477	somatodendritic compartment	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
http://purl.obolibrary.org/obo/GO_0040011	locomotion	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Self-propelled movement of a cell or organism from one location to another.
http://purl.obolibrary.org/obo/GO_0040020	regulation of meiotic nuclear division	http://purl.obolibrary.org/obo/GO_0051445	regulation of meiotic cell cycle		Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
http://purl.obolibrary.org/obo/GO_0042102	positive regulation of T cell proliferation	http://purl.obolibrary.org/obo/GO_0050870	positive regulation of T cell activation		Any process that activates or increases the rate or extent of T cell proliferation.
http://purl.obolibrary.org/obo/GO_0042129	regulation of T cell proliferation	http://purl.obolibrary.org/obo/GO_0050863	regulation of T cell activation		Any process that modulates the frequency, rate or extent of T cell proliferation.
http://purl.obolibrary.org/obo/GO_0042130	negative regulation of T cell proliferation	http://purl.obolibrary.org/obo/GO_0050868	negative regulation of T cell activation		Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
http://purl.obolibrary.org/obo/GO_0042246	tissue regeneration	http://purl.obolibrary.org/obo/GO_0031099	regeneration		The regrowth of lost or destroyed tissues.
http://purl.obolibrary.org/obo/GO_0042470	melanosome	http://purl.obolibrary.org/obo/GO_0048770	pigment granule		A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
http://purl.obolibrary.org/obo/GO_0042552	myelination	http://purl.obolibrary.org/obo/GO_0008366	axon ensheathment		The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
http://purl.obolibrary.org/obo/GO_0042611	MHC protein complex	http://purl.obolibrary.org/obo/GO_0098797	plasma membrane protein complex		A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.
http://purl.obolibrary.org/obo/GO_0042633	hair cycle	http://purl.obolibrary.org/obo/GO_0042303	molting cycle		The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.
http://purl.obolibrary.org/obo/GO_0042745	circadian sleep/wake cycle	http://purl.obolibrary.org/obo/GO_0048512	circadian behavior		The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
http://purl.obolibrary.org/obo/GO_0043025	neuronal cell body	http://purl.obolibrary.org/obo/GO_0044297	cell body		The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
http://purl.obolibrary.org/obo/GO_0043062	extracellular structure organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
http://purl.obolibrary.org/obo/GO_0043069	negative regulation of programmed cell death	http://purl.obolibrary.org/obo/GO_0043067	regulation of programmed cell death		Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
http://purl.obolibrary.org/obo/GO_0043217	myelin maintenance	http://purl.obolibrary.org/obo/GO_0007009	plasma membrane organization		The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.
http://purl.obolibrary.org/obo/GO_0043227	membrane-bounded organelle	http://purl.obolibrary.org/obo/GO_0043226	organelle		Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
http://purl.obolibrary.org/obo/GO_0043233	organelle lumen	http://purl.obolibrary.org/obo/GO_0031974	membrane-enclosed lumen		The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
http://purl.obolibrary.org/obo/GO_0043473	pigmentation	http://purl.obolibrary.org/obo/GO_0008150	biological_process		The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
http://purl.obolibrary.org/obo/GO_0043555	regulation of translation in response to stress	http://purl.obolibrary.org/obo/GO_0006417	regulation of translation		Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
http://purl.obolibrary.org/obo/GO_0043588	skin development	http://purl.obolibrary.org/obo/GO_0048513	animal organ development		The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
http://purl.obolibrary.org/obo/GO_0044057	regulation of system process	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
http://purl.obolibrary.org/obo/GO_0044092	negative regulation of molecular function	http://purl.obolibrary.org/obo/GO_0065009	regulation of molecular function		Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
http://purl.obolibrary.org/obo/GO_0044093	positive regulation of molecular function	http://purl.obolibrary.org/obo/GO_0065009	regulation of molecular function		Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
http://purl.obolibrary.org/obo/GO_0044782	cilium organization	http://purl.obolibrary.org/obo/GO_0006996	organelle organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
http://purl.obolibrary.org/obo/GO_0045202	synapse	http://purl.obolibrary.org/obo/GO_0030054	cell junction		The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
http://purl.obolibrary.org/obo/GO_0045580	regulation of T cell differentiation	http://purl.obolibrary.org/obo/GO_0050863	regulation of T cell activation		Any process that modulates the frequency, rate or extent of T cell differentiation.
http://purl.obolibrary.org/obo/GO_0045581	negative regulation of T cell differentiation	http://purl.obolibrary.org/obo/GO_0050868	negative regulation of T cell activation		Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.
http://purl.obolibrary.org/obo/GO_0045582	positive regulation of T cell differentiation	http://purl.obolibrary.org/obo/GO_0050870	positive regulation of T cell activation		Any process that activates or increases the frequency, rate or extent of T cell differentiation.
http://purl.obolibrary.org/obo/GO_0045619	regulation of lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0051249	regulation of lymphocyte activation		Any process that modulates the frequency, rate or extent of lymphocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045620	negative regulation of lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0051250	negative regulation of lymphocyte activation		Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045621	positive regulation of lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0051251	positive regulation of lymphocyte activation		Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045738	negative regulation of DNA repair	http://purl.obolibrary.org/obo/GO_0048585	negative regulation of response to stimulus		Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.
http://purl.obolibrary.org/obo/GO_0045739	positive regulation of DNA repair	http://purl.obolibrary.org/obo/GO_0051054	positive regulation of DNA metabolic process		Any process that activates or increases the frequency, rate or extent of DNA repair.
http://purl.obolibrary.org/obo/GO_0045763	negative regulation of amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.
http://purl.obolibrary.org/obo/GO_0045764	positive regulation of amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid.
http://purl.obolibrary.org/obo/GO_0045778	positive regulation of ossification	http://purl.obolibrary.org/obo/GO_0030278	regulation of ossification		Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
http://purl.obolibrary.org/obo/GO_0045835	negative regulation of meiotic nuclear division	http://purl.obolibrary.org/obo/GO_0010948	negative regulation of cell cycle process		Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
http://purl.obolibrary.org/obo/GO_0045836	positive regulation of meiotic nuclear division	http://purl.obolibrary.org/obo/GO_0090068	positive regulation of cell cycle process		Any process that activates or increases the frequency, rate or extent of meiosis.
http://purl.obolibrary.org/obo/GO_0045840	positive regulation of mitotic nuclear division	http://purl.obolibrary.org/obo/GO_0090068	positive regulation of cell cycle process		Any process that activates or increases the frequency, rate or extent of mitosis.
http://purl.obolibrary.org/obo/GO_0045926	negative regulation of growth	http://purl.obolibrary.org/obo/GO_0048519	negative regulation of biological process		Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.
http://purl.obolibrary.org/obo/GO_0045927	positive regulation of growth	http://purl.obolibrary.org/obo/GO_0048518	positive regulation of biological process		Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
http://purl.obolibrary.org/obo/GO_0045947	negative regulation of translational initiation	http://purl.obolibrary.org/obo/GO_0017148	negative regulation of translation		Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.
http://purl.obolibrary.org/obo/GO_0045948	positive regulation of translational initiation	http://purl.obolibrary.org/obo/GO_0045727	positive regulation of translation		Any process that activates or increases the frequency, rate or extent of translational initiation.
http://purl.obolibrary.org/obo/GO_0046364	monosaccharide biosynthetic process	http://purl.obolibrary.org/obo/GO_0044283	small molecule biosynthetic process		The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.
http://purl.obolibrary.org/obo/GO_0046660	female sex differentiation	http://purl.obolibrary.org/obo/GO_0007548	sex differentiation		The establishment of the sex of a female organism by physical differentiation.
http://purl.obolibrary.org/obo/GO_0046887	positive regulation of hormone secretion	http://purl.obolibrary.org/obo/GO_0010647	positive regulation of cell communication		Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.
http://purl.obolibrary.org/obo/GO_0046888	negative regulation of hormone secretion	http://purl.obolibrary.org/obo/GO_0010648	negative regulation of cell communication		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.
http://purl.obolibrary.org/obo/GO_0048521	negative regulation of behavior	http://purl.obolibrary.org/obo/GO_0050795	regulation of behavior		Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
http://purl.obolibrary.org/obo/GO_0048640	negative regulation of developmental growth	http://purl.obolibrary.org/obo/GO_0048638	regulation of developmental growth		Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.
http://purl.obolibrary.org/obo/GO_0048736	appendage development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.
http://purl.obolibrary.org/obo/GO_0050670	regulation of lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0051249	regulation of lymphocyte activation		Any process that modulates the frequency, rate or extent of lymphocyte proliferation.
http://purl.obolibrary.org/obo/GO_0050671	positive regulation of lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0051251	positive regulation of lymphocyte activation		Any process that activates or increases the rate or extent of lymphocyte proliferation.
http://purl.obolibrary.org/obo/GO_0050672	negative regulation of lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0051250	negative regulation of lymphocyte activation		Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.
http://purl.obolibrary.org/obo/GO_0050687	negative regulation of defense response to virus	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.
http://purl.obolibrary.org/obo/GO_0050714	positive regulation of protein secretion	http://purl.obolibrary.org/obo/GO_0051222	positive regulation of protein transport		Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
http://purl.obolibrary.org/obo/GO_0050795	regulation of behavior	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
http://purl.obolibrary.org/obo/GO_0050796	regulation of insulin secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that modulates the frequency, rate or extent of the regulated release of insulin.
http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission	http://purl.obolibrary.org/obo/GO_0099177	regulation of trans-synaptic signaling		Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
http://purl.obolibrary.org/obo/GO_0050805	negative regulation of synaptic transmission	http://purl.obolibrary.org/obo/GO_0010648	negative regulation of cell communication		Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
http://purl.obolibrary.org/obo/GO_0050818	regulation of coagulation	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass.
http://purl.obolibrary.org/obo/GO_0050819	negative regulation of coagulation	http://purl.obolibrary.org/obo/GO_0050818	regulation of coagulation		Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.
http://purl.obolibrary.org/obo/GO_0050820	positive regulation of coagulation	http://purl.obolibrary.org/obo/GO_0050818	regulation of coagulation		Any process that activates or increases the frequency, rate or extent of coagulation.
http://purl.obolibrary.org/obo/GO_0050864	regulation of B cell activation	http://purl.obolibrary.org/obo/GO_0051249	regulation of lymphocyte activation		Any process that modulates the frequency, rate or extent of B cell activation.
http://purl.obolibrary.org/obo/GO_0050869	negative regulation of B cell activation	http://purl.obolibrary.org/obo/GO_0051250	negative regulation of lymphocyte activation		Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
http://purl.obolibrary.org/obo/GO_0050870	positive regulation of T cell activation	http://purl.obolibrary.org/obo/GO_0050863	regulation of T cell activation		Any process that activates or increases the frequency, rate or extent of T cell activation.
http://purl.obolibrary.org/obo/GO_0050871	positive regulation of B cell activation	http://purl.obolibrary.org/obo/GO_0051251	positive regulation of lymphocyte activation		Any process that activates or increases the frequency, rate or extent of B cell activation.
http://purl.obolibrary.org/obo/GO_0050884	neuromuscular process controlling posture	http://purl.obolibrary.org/obo/GO_0050905	neuromuscular process		Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts.
http://purl.obolibrary.org/obo/GO_0051054	positive regulation of DNA metabolic process	http://purl.obolibrary.org/obo/GO_0051052	regulation of DNA metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.
http://purl.obolibrary.org/obo/GO_0051179	localization	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.
http://purl.obolibrary.org/obo/GO_0051223	regulation of protein transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051246	regulation of protein metabolic process	http://purl.obolibrary.org/obo/GO_0060255	regulation of macromolecule metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
http://purl.obolibrary.org/obo/GO_0051247	positive regulation of protein metabolic process	http://purl.obolibrary.org/obo/GO_0051246	regulation of protein metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
http://purl.obolibrary.org/obo/GO_0051248	negative regulation of protein metabolic process	http://purl.obolibrary.org/obo/GO_0051246	regulation of protein metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
http://purl.obolibrary.org/obo/GO_0051249	regulation of lymphocyte activation	http://purl.obolibrary.org/obo/GO_0002694	regulation of leukocyte activation		Any process that modulates the frequency, rate or extent of lymphocyte activation.
http://purl.obolibrary.org/obo/GO_0051250	negative regulation of lymphocyte activation	http://purl.obolibrary.org/obo/GO_0051249	regulation of lymphocyte activation		Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.
http://purl.obolibrary.org/obo/GO_0051251	positive regulation of lymphocyte activation	http://purl.obolibrary.org/obo/GO_0051249	regulation of lymphocyte activation		Any process that activates or increases the frequency, rate or extent of lymphocyte activation.
http://purl.obolibrary.org/obo/GO_0051253	negative regulation of RNA metabolic process	http://purl.obolibrary.org/obo/GO_0045934	negative regulation of nucleobase-containing compound metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.
http://purl.obolibrary.org/obo/GO_0051349	positive regulation of lyase activity	http://purl.obolibrary.org/obo/GO_0043085	positive regulation of catalytic activity		Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
http://purl.obolibrary.org/obo/GO_0051354	negative regulation of oxidoreductase activity	http://purl.obolibrary.org/obo/GO_0051341	regulation of oxidoreductase activity		Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
http://purl.obolibrary.org/obo/GO_0051668	localization within membrane	http://purl.obolibrary.org/obo/GO_0051641	cellular localization		Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.
http://purl.obolibrary.org/obo/GO_0051781	positive regulation of cell division	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of cell division.
http://purl.obolibrary.org/obo/GO_0051782	negative regulation of cell division	http://purl.obolibrary.org/obo/GO_0051302	regulation of cell division		Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.
http://purl.obolibrary.org/obo/GO_0051932	synaptic transmission, GABAergic	http://purl.obolibrary.org/obo/GO_0007268	chemical synaptic transmission		The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
http://purl.obolibrary.org/obo/GO_0051960	regulation of nervous system development	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
http://purl.obolibrary.org/obo/GO_0051961	negative regulation of nervous system development	http://purl.obolibrary.org/obo/GO_0051960	regulation of nervous system development		Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
http://purl.obolibrary.org/obo/GO_0051962	positive regulation of nervous system development	http://purl.obolibrary.org/obo/GO_0051960	regulation of nervous system development		Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
http://purl.obolibrary.org/obo/GO_0051983	regulation of chromosome segregation	http://purl.obolibrary.org/obo/GO_0010564	regulation of cell cycle process		Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
http://purl.obolibrary.org/obo/GO_0051985	negative regulation of chromosome segregation	http://purl.obolibrary.org/obo/GO_0010948	negative regulation of cell cycle process		Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
http://purl.obolibrary.org/obo/GO_0055080	monoatomic cation homeostasis	http://purl.obolibrary.org/obo/GO_0050801	monoatomic ion homeostasis		Any process involved in the maintenance of an internal steady state of monoatomic cations within an organism or cell. Monatomic cations (also called simple cations) are cations consisting of exactly one atom.
http://purl.obolibrary.org/obo/GO_0060142	regulation of syncytium formation by plasma membrane fusion	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
http://purl.obolibrary.org/obo/GO_0060143	positive regulation of syncytium formation by plasma membrane fusion	http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization		Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.
http://purl.obolibrary.org/obo/GO_0061036	positive regulation of cartilage development	http://purl.obolibrary.org/obo/GO_0061035	regulation of cartilage development		Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
http://purl.obolibrary.org/obo/GO_0061037	negative regulation of cartilage development	http://purl.obolibrary.org/obo/GO_0061035	regulation of cartilage development		Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
http://purl.obolibrary.org/obo/GO_0061041	regulation of wound healing	http://purl.obolibrary.org/obo/GO_1903034	regulation of response to wounding		Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
http://purl.obolibrary.org/obo/GO_0061045	negative regulation of wound healing	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
http://purl.obolibrary.org/obo/GO_0065010	extracellular membrane-bounded organelle	http://purl.obolibrary.org/obo/GO_0043230	extracellular organelle		Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.
http://purl.obolibrary.org/obo/GO_0070167	regulation of biomineral tissue development	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
http://purl.obolibrary.org/obo/GO_0070168	negative regulation of biomineral tissue development	http://purl.obolibrary.org/obo/GO_0070167	regulation of biomineral tissue development		Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
http://purl.obolibrary.org/obo/GO_0070169	positive regulation of biomineral tissue development	http://purl.obolibrary.org/obo/GO_0070167	regulation of biomineral tissue development		Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
http://purl.obolibrary.org/obo/GO_0070587	regulation of cell-cell adhesion involved in gastrulation	http://purl.obolibrary.org/obo/GO_0022407	regulation of cell-cell adhesion		Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation.
http://purl.obolibrary.org/obo/GO_0070663	regulation of leukocyte proliferation	http://purl.obolibrary.org/obo/GO_0042127	regulation of cell population proliferation		Any process that modulates the frequency, rate or extent of leukocyte proliferation.
http://purl.obolibrary.org/obo/GO_0070664	negative regulation of leukocyte proliferation	http://purl.obolibrary.org/obo/GO_0008285	negative regulation of cell population proliferation		Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.
http://purl.obolibrary.org/obo/GO_0070665	positive regulation of leukocyte proliferation	http://purl.obolibrary.org/obo/GO_0070663	regulation of leukocyte proliferation		Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.
http://purl.obolibrary.org/obo/GO_0071345	cellular response to cytokine stimulus	http://purl.obolibrary.org/obo/GO_0034097	response to cytokine		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
http://purl.obolibrary.org/obo/GO_0071826	protein-RNA complex organization	http://purl.obolibrary.org/obo/GO_0043933	protein-containing complex organization		Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.
http://purl.obolibrary.org/obo/GO_0090031	positive regulation of steroid hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0046886	positive regulation of hormone biosynthetic process		Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.
http://purl.obolibrary.org/obo/GO_0090277	positive regulation of peptide hormone secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
http://purl.obolibrary.org/obo/GO_0090303	positive regulation of wound healing	http://purl.obolibrary.org/obo/GO_0061041	regulation of wound healing		Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
http://purl.obolibrary.org/obo/GO_0090322	regulation of superoxide metabolic process	http://purl.obolibrary.org/obo/GO_2000377	regulation of reactive oxygen species metabolic process		Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
http://purl.obolibrary.org/obo/GO_0097060	synaptic membrane	http://purl.obolibrary.org/obo/GO_0098590	plasma membrane region		A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
http://purl.obolibrary.org/obo/GO_0097708	intracellular vesicle	http://purl.obolibrary.org/obo/GO_0031982	vesicle		Any vesicle that is part of the intracellular region.
http://purl.obolibrary.org/obo/GO_0097722	sperm motility	http://purl.obolibrary.org/obo/GO_0048870	cell motility		Any process involved in the controlled movement of a sperm cell.
http://purl.obolibrary.org/obo/GO_0099503	secretory vesicle	http://purl.obolibrary.org/obo/GO_0031410	cytoplasmic vesicle		A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.
http://purl.obolibrary.org/obo/GO_1900046	regulation of hemostasis	http://purl.obolibrary.org/obo/GO_0050878	regulation of body fluid levels		Any process that modulates the frequency, rate or extent of hemostasis.
http://purl.obolibrary.org/obo/GO_1900047	negative regulation of hemostasis	http://purl.obolibrary.org/obo/GO_1900046	regulation of hemostasis		Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis.
http://purl.obolibrary.org/obo/GO_1900048	positive regulation of hemostasis	http://purl.obolibrary.org/obo/GO_1900046	regulation of hemostasis		Any process that activates or increases the frequency, rate or extent of hemostasis.
http://purl.obolibrary.org/obo/GO_1901334	lactone metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving lactone.
http://purl.obolibrary.org/obo/GO_1901652	response to peptide	http://purl.obolibrary.org/obo/GO_0042221	response to chemical		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
http://purl.obolibrary.org/obo/GO_1901654	response to ketone	http://purl.obolibrary.org/obo/GO_1901700	response to oxygen-containing compound		A response that results in a state of tolerance to ketone.
http://purl.obolibrary.org/obo/GO_1903131	mononuclear cell differentiation	http://purl.obolibrary.org/obo/GO_0002521	leukocyte differentiation		The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.
http://purl.obolibrary.org/obo/GO_1903353	regulation of nucleus organization	http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization		Any process that modulates the frequency, rate or extent of nucleus organization.
http://purl.obolibrary.org/obo/GO_1905332	positive regulation of morphogenesis of an epithelium	http://purl.obolibrary.org/obo/GO_1905330	regulation of morphogenesis of an epithelium		Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.
http://purl.obolibrary.org/obo/GO_1905879	regulation of oogenesis	http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process		Any process that modulates the frequency, rate or extent of oogenesis.
http://purl.obolibrary.org/obo/GO_1905880	negative regulation of oogenesis	http://purl.obolibrary.org/obo/GO_2000242	negative regulation of reproductive process		Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis.
http://purl.obolibrary.org/obo/GO_1905881	positive regulation of oogenesis	http://purl.obolibrary.org/obo/GO_2000243	positive regulation of reproductive process		Any process that activates or increases the frequency, rate or extent of oogenesis.
http://purl.obolibrary.org/obo/GO_1990266	neutrophil migration	http://purl.obolibrary.org/obo/GO_0097530	granulocyte migration		The movement of a neutrophil within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_1990351	transporter complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells.
http://purl.obolibrary.org/obo/GO_2000106	regulation of leukocyte apoptotic process	http://purl.obolibrary.org/obo/GO_0042981	regulation of apoptotic process		Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.
http://purl.obolibrary.org/obo/GO_2000107	negative regulation of leukocyte apoptotic process	http://purl.obolibrary.org/obo/GO_2000106	regulation of leukocyte apoptotic process		Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.
http://purl.obolibrary.org/obo/GO_2000108	positive regulation of leukocyte apoptotic process	http://purl.obolibrary.org/obo/GO_0043065	positive regulation of apoptotic process		Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.
http://purl.obolibrary.org/obo/GO_2000145	regulation of cell motility	http://purl.obolibrary.org/obo/GO_0040012	regulation of locomotion		Any process that modulates the frequency, rate or extent of cell motility.
http://purl.obolibrary.org/obo/GO_2000146	negative regulation of cell motility	http://purl.obolibrary.org/obo/GO_0040013	negative regulation of locomotion		Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.
http://purl.obolibrary.org/obo/GO_2000147	positive regulation of cell motility	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of cell motility.
http://purl.obolibrary.org/obo/GO_2001251	negative regulation of chromosome organization	http://purl.obolibrary.org/obo/GO_0010639	negative regulation of organelle organization		Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization.
http://purl.obolibrary.org/obo/GO_2001252	positive regulation of chromosome organization	http://purl.obolibrary.org/obo/GO_0010638	positive regulation of organelle organization		Any process that activates or increases the frequency, rate or extent of chromosome organization.
http://purl.obolibrary.org/obo/GO_0034358	plasma lipoprotein particle	http://purl.obolibrary.org/obo/GO_0140392	extracellular protein-containing complex		A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0034505	tooth mineralization	http://purl.obolibrary.org/obo/GO_0031214	biomineral tissue development		The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum.
http://purl.obolibrary.org/obo/GO_0034763	negative regulation of transmembrane transport	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0034764	positive regulation of transmembrane transport	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_0035148	tube formation	http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis		Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
http://purl.obolibrary.org/obo/GO_0035249	synaptic transmission, glutamatergic	http://purl.obolibrary.org/obo/GO_0007268	chemical synaptic transmission		The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
http://purl.obolibrary.org/obo/GO_0035369	pre-B cell receptor complex	http://purl.obolibrary.org/obo/GO_0098796	membrane protein complex		An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
http://purl.obolibrary.org/obo/GO_0035592	establishment of protein localization to extracellular region	http://purl.obolibrary.org/obo/GO_0045184	establishment of protein localization		The directed movement of a protein to a specific location within the extracellular region.
http://purl.obolibrary.org/obo/GO_0035630	bone mineralization involved in bone maturation	http://purl.obolibrary.org/obo/GO_0030282	bone mineralization		The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state.
http://purl.obolibrary.org/obo/GO_0035735	intraciliary transport involved in cilium assembly	http://purl.obolibrary.org/obo/GO_0042073	intraciliary transport		The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.
http://purl.obolibrary.org/obo/GO_0035809	regulation of urine volume	http://purl.obolibrary.org/obo/GO_0050878	regulation of body fluid levels		Any process that modulates the amount of urine excreted from the body over a unit of time.
http://purl.obolibrary.org/obo/GO_0035821	modulation of process of another organism	http://purl.obolibrary.org/obo/GO_0044419	biological process involved in interspecies interaction between organisms		A process in which an organism effects a change in a biological process in another organism.
http://purl.obolibrary.org/obo/GO_0035878	nail development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.
http://purl.obolibrary.org/obo/GO_0035898	parathyroid hormone secretion	http://purl.obolibrary.org/obo/GO_0046879	hormone secretion		The regulated release of parathyroid hormone into the circulatory system.
http://purl.obolibrary.org/obo/GO_0035929	steroid hormone secretion	http://purl.obolibrary.org/obo/GO_0140353	lipid export from cell		The regulated release of any steroid that acts as a hormone into the circulatory system.
http://purl.obolibrary.org/obo/GO_0035930	corticosteroid hormone secretion	http://purl.obolibrary.org/obo/GO_0035929	steroid hormone secretion		The regulated release of any corticosteroid hormone into the circulatory system.
http://purl.obolibrary.org/obo/GO_0035931	mineralocorticoid secretion	http://purl.obolibrary.org/obo/GO_0035930	corticosteroid hormone secretion		The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism.
http://purl.obolibrary.org/obo/GO_0035935	androgen secretion	http://purl.obolibrary.org/obo/GO_0035929	steroid hormone secretion		The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.
http://purl.obolibrary.org/obo/GO_0035936	testosterone secretion	http://purl.obolibrary.org/obo/GO_0140353	lipid export from cell		The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.
http://purl.obolibrary.org/obo/GO_0036053	glomerular endothelium fenestra	http://purl.obolibrary.org/obo/GO_0046930	pore complex		A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes.
http://purl.obolibrary.org/obo/GO_0036066	protein O-linked glycosylation via fucose	http://purl.obolibrary.org/obo/GO_0006493	protein O-linked glycosylation		A glycoprotein biosynthetic process starting with the covalent linkage of a fucose via an alpha-glycosidic bond to the oxygen atom of a serine or threonine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan. This modification typically occurs within specific motifs, such as EGF-like or thrombospondin type-1 repeats.
http://purl.obolibrary.org/obo/GO_0036160	melanocyte-stimulating hormone secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation.
http://purl.obolibrary.org/obo/GO_0036161	calcitonin secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell.
http://purl.obolibrary.org/obo/GO_0036194	muscle cell projection	http://purl.obolibrary.org/obo/GO_0120025	plasma membrane bounded cell projection		A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
http://purl.obolibrary.org/obo/GO_0040012	regulation of locomotion	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
http://purl.obolibrary.org/obo/GO_0040013	negative regulation of locomotion	http://purl.obolibrary.org/obo/GO_0040012	regulation of locomotion		Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.
http://purl.obolibrary.org/obo/GO_0040016	embryonic cleavage	http://purl.obolibrary.org/obo/GO_0051301	cell division		The first few specialized divisions of an activated animal egg.
http://purl.obolibrary.org/obo/GO_0040017	positive regulation of locomotion	http://purl.obolibrary.org/obo/GO_0040012	regulation of locomotion		Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
http://purl.obolibrary.org/obo/GO_0040019	positive regulation of embryonic development	http://purl.obolibrary.org/obo/GO_0051240	positive regulation of multicellular organismal process		Any process that activates or increases the frequency, rate or extent of embryonic development.
http://purl.obolibrary.org/obo/GO_0042065	glial cell growth	http://purl.obolibrary.org/obo/GO_0048588	developmental cell growth		Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
http://purl.obolibrary.org/obo/GO_0042073	intraciliary transport	http://purl.obolibrary.org/obo/GO_0010970	transport along microtubule		The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.
http://purl.obolibrary.org/obo/GO_0042101	T cell receptor complex	http://purl.obolibrary.org/obo/GO_0098802	plasma membrane signaling receptor complex		A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
http://purl.obolibrary.org/obo/GO_0042105	alpha-beta T cell receptor complex	http://purl.obolibrary.org/obo/GO_0042101	T cell receptor complex		A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.
http://purl.obolibrary.org/obo/GO_0042106	gamma-delta T cell receptor complex	http://purl.obolibrary.org/obo/GO_0042101	T cell receptor complex		A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.
http://purl.obolibrary.org/obo/GO_0042320	regulation of circadian sleep/wake cycle, REM sleep	http://purl.obolibrary.org/obo/GO_0045187	regulation of circadian sleep/wake cycle, sleep		Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.
http://purl.obolibrary.org/obo/GO_0042321	negative regulation of circadian sleep/wake cycle, sleep	http://purl.obolibrary.org/obo/GO_0045187	regulation of circadian sleep/wake cycle, sleep		Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
http://purl.obolibrary.org/obo/GO_0042322	negative regulation of circadian sleep/wake cycle, REM sleep	http://purl.obolibrary.org/obo/GO_0042321	negative regulation of circadian sleep/wake cycle, sleep		Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.
http://purl.obolibrary.org/obo/GO_0042359	vitamin D metabolic process	http://purl.obolibrary.org/obo/GO_0008202	steroid metabolic process		The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).
http://purl.obolibrary.org/obo/GO_0042405	nuclear inclusion body	http://purl.obolibrary.org/obo/GO_0016234	inclusion body		An intranuclear focus at which aggregated proteins have been sequestered.
http://purl.obolibrary.org/obo/GO_0042465	kinesis	http://purl.obolibrary.org/obo/GO_0009605	response to external stimulus		The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus.
http://purl.obolibrary.org/obo/GO_0042475	odontogenesis of dentin-containing tooth	http://purl.obolibrary.org/obo/GO_0042476	odontogenesis		The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
http://purl.obolibrary.org/obo/GO_0042476	odontogenesis	http://purl.obolibrary.org/obo/GO_0009887	animal organ morphogenesis		The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
http://purl.obolibrary.org/obo/GO_0042481	regulation of odontogenesis	http://purl.obolibrary.org/obo/GO_2000027	regulation of animal organ morphogenesis		Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.
http://purl.obolibrary.org/obo/GO_0042482	positive regulation of odontogenesis	http://purl.obolibrary.org/obo/GO_0042481	regulation of odontogenesis		Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.
http://purl.obolibrary.org/obo/GO_0042483	negative regulation of odontogenesis	http://purl.obolibrary.org/obo/GO_0042481	regulation of odontogenesis		Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth.
http://purl.obolibrary.org/obo/GO_0042487	regulation of odontogenesis of dentin-containing tooth	http://purl.obolibrary.org/obo/GO_0042481	regulation of odontogenesis		Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.
http://purl.obolibrary.org/obo/GO_0042488	positive regulation of odontogenesis of dentin-containing tooth	http://purl.obolibrary.org/obo/GO_0042487	regulation of odontogenesis of dentin-containing tooth		Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.
http://purl.obolibrary.org/obo/GO_0042489	negative regulation of odontogenesis of dentin-containing tooth	http://purl.obolibrary.org/obo/GO_0042487	regulation of odontogenesis of dentin-containing tooth		Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.
http://purl.obolibrary.org/obo/GO_0042571	immunoglobulin complex, circulating	http://purl.obolibrary.org/obo/GO_0140392	extracellular protein-containing complex		An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
http://purl.obolibrary.org/obo/GO_0042582	azurophil granule	http://purl.obolibrary.org/obo/GO_0030141	secretory granule		Primary lysosomal granule readily stainable with a Romanowsky stain.
http://purl.obolibrary.org/obo/GO_0042588	zymogen granule	http://purl.obolibrary.org/obo/GO_0030141	secretory granule		A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.
http://purl.obolibrary.org/obo/GO_0042589	zymogen granule membrane	http://purl.obolibrary.org/obo/GO_0030667	secretory granule membrane		The lipid bilayer surrounding a zymogen granule.
http://purl.obolibrary.org/obo/GO_0042599	lamellar body	http://purl.obolibrary.org/obo/GO_0030141	secretory granule		A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.
http://purl.obolibrary.org/obo/GO_0042613	MHC class II protein complex	http://purl.obolibrary.org/obo/GO_0042611	MHC protein complex		A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.
http://purl.obolibrary.org/obo/GO_0042627	chylomicron	http://purl.obolibrary.org/obo/GO_0034358	plasma lipoprotein particle		A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.
http://purl.obolibrary.org/obo/GO_0042634	regulation of hair cycle	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
http://purl.obolibrary.org/obo/GO_0042635	positive regulation of hair cycle	http://purl.obolibrary.org/obo/GO_0042634	regulation of hair cycle		Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
http://purl.obolibrary.org/obo/GO_0042636	negative regulation of hair cycle	http://purl.obolibrary.org/obo/GO_0042634	regulation of hair cycle		Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.
http://purl.obolibrary.org/obo/GO_0042695	thelarche	http://purl.obolibrary.org/obo/GO_0046543	development of animal secondary female sexual characteristics		The beginning of development of the breasts in the female.
http://purl.obolibrary.org/obo/GO_0042696	menarche	http://purl.obolibrary.org/obo/GO_0022601	menstrual cycle phase		The beginning of the menstrual cycle; the first menstrual cycle in an individual.
http://purl.obolibrary.org/obo/GO_0042703	menstruation	http://purl.obolibrary.org/obo/GO_0022601	menstrual cycle phase		The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.
http://purl.obolibrary.org/obo/GO_0042713	sperm ejaculation	http://purl.obolibrary.org/obo/GO_0048609	multicellular organismal reproductive process		The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.
http://purl.obolibrary.org/obo/GO_0042730	fibrinolysis	http://purl.obolibrary.org/obo/GO_0030195	negative regulation of blood coagulation		A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
http://purl.obolibrary.org/obo/GO_0042747	circadian sleep/wake cycle, REM sleep	http://purl.obolibrary.org/obo/GO_0022410	circadian sleep/wake cycle process		A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity.
http://purl.obolibrary.org/obo/GO_0042754	negative regulation of circadian rhythm	http://purl.obolibrary.org/obo/GO_0042752	regulation of circadian rhythm		Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
http://purl.obolibrary.org/obo/GO_0043038	amino acid activation	http://purl.obolibrary.org/obo/GO_0006520	amino acid metabolic process		The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.
http://purl.obolibrary.org/obo/GO_0043084	penile erection	http://purl.obolibrary.org/obo/GO_0048609	multicellular organismal reproductive process		The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.
http://purl.obolibrary.org/obo/GO_0043129	surfactant homeostasis	http://purl.obolibrary.org/obo/GO_0140962	multicellular organismal-level chemical homeostasis		Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.
http://purl.obolibrary.org/obo/GO_0043143	regulation of translation by machinery localization	http://purl.obolibrary.org/obo/GO_0008104	intracellular protein localization		Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.
http://purl.obolibrary.org/obo/GO_0043209	myelin sheath	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
http://purl.obolibrary.org/obo/GO_0043229	intracellular organelle	http://purl.obolibrary.org/obo/GO_0043226	organelle		Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
http://purl.obolibrary.org/obo/GO_0043230	extracellular organelle	http://purl.obolibrary.org/obo/GO_0043226	organelle		Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.
http://purl.obolibrary.org/obo/GO_0043242	negative regulation of protein-containing complex disassembly	http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization		Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
http://purl.obolibrary.org/obo/GO_0043243	positive regulation of protein-containing complex disassembly	http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization		Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.
http://purl.obolibrary.org/obo/GO_0043264	extracellular membraneless organelle	http://purl.obolibrary.org/obo/GO_0043228	membraneless organelle		Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.
http://purl.obolibrary.org/obo/GO_0043368	positive T cell selection	http://purl.obolibrary.org/obo/GO_0045058	T cell selection		The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
http://purl.obolibrary.org/obo/GO_0043379	memory T cell differentiation	http://purl.obolibrary.org/obo/GO_0090715	immunological memory formation process		The process in which a newly activated T cell acquires specialized features of a memory T cell.
http://purl.obolibrary.org/obo/GO_0043380	regulation of memory T cell differentiation	http://purl.obolibrary.org/obo/GO_0045580	regulation of T cell differentiation		Any process that modulates the frequency, rate, or extent of memory T cell differentiation.
http://purl.obolibrary.org/obo/GO_0043381	negative regulation of memory T cell differentiation	http://purl.obolibrary.org/obo/GO_0043380	regulation of memory T cell differentiation		Any process that stops, prevents, or reduces the rate of memory T cell differentiation.
http://purl.obolibrary.org/obo/GO_0043382	positive regulation of memory T cell differentiation	http://purl.obolibrary.org/obo/GO_0043380	regulation of memory T cell differentiation		Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.
http://purl.obolibrary.org/obo/GO_0043384	pre-T cell receptor complex	http://purl.obolibrary.org/obo/GO_0098802	plasma membrane signaling receptor complex		A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins.
http://purl.obolibrary.org/obo/GO_0043474	pigment metabolic process involved in pigmentation	http://purl.obolibrary.org/obo/GO_0042440	pigment metabolic process		The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell.
http://purl.obolibrary.org/obo/GO_0043504	mitochondrial DNA repair	http://purl.obolibrary.org/obo/GO_0006281	DNA repair		The process of restoring mitochondrial DNA after damage.
http://purl.obolibrary.org/obo/GO_0043576	regulation of respiratory gaseous exchange	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.
http://purl.obolibrary.org/obo/GO_0043903	regulation of biological process involved in symbiotic interaction	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.
http://purl.obolibrary.org/obo/GO_0043931	ossification involved in bone maturation	http://purl.obolibrary.org/obo/GO_0001503	ossification		The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.
http://purl.obolibrary.org/obo/GO_0043932	ossification involved in bone remodeling	http://purl.obolibrary.org/obo/GO_0001503	ossification		The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.
http://purl.obolibrary.org/obo/GO_0044058	regulation of digestive system process	http://purl.obolibrary.org/obo/GO_0044057	regulation of system process		Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
http://purl.obolibrary.org/obo/GO_0044062	regulation of excretion	http://purl.obolibrary.org/obo/GO_0044057	regulation of system process		Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.
http://purl.obolibrary.org/obo/GO_0044292	dendrite terminus	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole.
http://purl.obolibrary.org/obo/GO_0044293	dendriole	http://purl.obolibrary.org/obo/GO_0044292	dendrite terminus		Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC).
http://purl.obolibrary.org/obo/GO_0044297	cell body	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
http://purl.obolibrary.org/obo/GO_0044307	dendritic branch	http://purl.obolibrary.org/obo/GO_0030425	dendrite		A dendrite arising from another dendrite.
http://purl.obolibrary.org/obo/GO_0044458	motile cilium assembly	http://purl.obolibrary.org/obo/GO_0060271	cilium assembly		The aggregation, arrangement and bonding together of a set of components to form a motile cilium.
http://purl.obolibrary.org/obo/GO_0045058	T cell selection	http://purl.obolibrary.org/obo/GO_0002376	immune system process		The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.
http://purl.obolibrary.org/obo/GO_0045095	keratin filament	http://purl.obolibrary.org/obo/GO_0005882	intermediate filament		A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.
http://purl.obolibrary.org/obo/GO_0045124	regulation of bone resorption	http://purl.obolibrary.org/obo/GO_0046850	regulation of bone remodeling		Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).
http://purl.obolibrary.org/obo/GO_0045136	development of animal secondary sexual characteristics	http://purl.obolibrary.org/obo/GO_0003006	developmental process involved in reproduction		The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In mammals, examples include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.
http://purl.obolibrary.org/obo/GO_0045144	meiotic sister chromatid segregation	http://purl.obolibrary.org/obo/GO_0000819	sister chromatid segregation		The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle.
http://purl.obolibrary.org/obo/GO_0045187	regulation of circadian sleep/wake cycle, sleep	http://purl.obolibrary.org/obo/GO_0042749	regulation of circadian sleep/wake cycle		Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.
http://purl.obolibrary.org/obo/GO_0045190	isotype switching	http://purl.obolibrary.org/obo/GO_0002312	B cell activation involved in immune response		The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus.
http://purl.obolibrary.org/obo/GO_0045191	regulation of isotype switching	http://purl.obolibrary.org/obo/GO_0050864	regulation of B cell activation		Any process that modulates the frequency, rate or extent of isotype switching.
http://purl.obolibrary.org/obo/GO_0045211	postsynaptic membrane	http://purl.obolibrary.org/obo/GO_0097060	synaptic membrane		A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
http://purl.obolibrary.org/obo/GO_0045453	bone resorption	http://purl.obolibrary.org/obo/GO_0001894	tissue homeostasis		The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
http://purl.obolibrary.org/obo/GO_0045586	regulation of gamma-delta T cell differentiation	http://purl.obolibrary.org/obo/GO_0046643	regulation of gamma-delta T cell activation		Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation.
http://purl.obolibrary.org/obo/GO_0045587	negative regulation of gamma-delta T cell differentiation	http://purl.obolibrary.org/obo/GO_0046644	negative regulation of gamma-delta T cell activation		Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation.
http://purl.obolibrary.org/obo/GO_0045588	positive regulation of gamma-delta T cell differentiation	http://purl.obolibrary.org/obo/GO_0046645	positive regulation of gamma-delta T cell activation		Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation.
http://purl.obolibrary.org/obo/GO_0045604	regulation of epidermal cell differentiation	http://purl.obolibrary.org/obo/GO_0045682	regulation of epidermis development		Any process that modulates the frequency, rate or extent of epidermal cell differentiation.
http://purl.obolibrary.org/obo/GO_0045605	negative regulation of epidermal cell differentiation	http://purl.obolibrary.org/obo/GO_0045683	negative regulation of epidermis development		Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.
http://purl.obolibrary.org/obo/GO_0045606	positive regulation of epidermal cell differentiation	http://purl.obolibrary.org/obo/GO_0045684	positive regulation of epidermis development		Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.
http://purl.obolibrary.org/obo/GO_0045616	regulation of keratinocyte differentiation	http://purl.obolibrary.org/obo/GO_0045604	regulation of epidermal cell differentiation		Any process that modulates the frequency, rate or extent of keratinocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045617	negative regulation of keratinocyte differentiation	http://purl.obolibrary.org/obo/GO_0045616	regulation of keratinocyte differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045618	positive regulation of keratinocyte differentiation	http://purl.obolibrary.org/obo/GO_0045616	regulation of keratinocyte differentiation		Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045640	regulation of basophil differentiation	http://purl.obolibrary.org/obo/GO_0030852	regulation of granulocyte differentiation		Any process that modulates the frequency, rate or extent of basophil differentiation.
http://purl.obolibrary.org/obo/GO_0045641	negative regulation of basophil differentiation	http://purl.obolibrary.org/obo/GO_0045640	regulation of basophil differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation.
http://purl.obolibrary.org/obo/GO_0045642	positive regulation of basophil differentiation	http://purl.obolibrary.org/obo/GO_0045640	regulation of basophil differentiation		Any process that activates or increases the frequency, rate or extent of basophil differentiation.
http://purl.obolibrary.org/obo/GO_0045647	negative regulation of erythrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045646	regulation of erythrocyte differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045648	positive regulation of erythrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045646	regulation of erythrocyte differentiation		Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045652	regulation of megakaryocyte differentiation	http://purl.obolibrary.org/obo/GO_0045637	regulation of myeloid cell differentiation		Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045653	negative regulation of megakaryocyte differentiation	http://purl.obolibrary.org/obo/GO_0045652	regulation of megakaryocyte differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045654	positive regulation of megakaryocyte differentiation	http://purl.obolibrary.org/obo/GO_0045652	regulation of megakaryocyte differentiation		Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045655	regulation of monocyte differentiation	http://purl.obolibrary.org/obo/GO_0002761	regulation of myeloid leukocyte differentiation		Any process that modulates the frequency, rate or extent of monocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045656	negative regulation of monocyte differentiation	http://purl.obolibrary.org/obo/GO_0045655	regulation of monocyte differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045657	positive regulation of monocyte differentiation	http://purl.obolibrary.org/obo/GO_0045655	regulation of monocyte differentiation		Any process that activates or increases the frequency, rate or extent of monocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045670	regulation of osteoclast differentiation	http://purl.obolibrary.org/obo/GO_0002761	regulation of myeloid leukocyte differentiation		Any process that modulates the frequency, rate or extent of osteoclast differentiation.
http://purl.obolibrary.org/obo/GO_0045671	negative regulation of osteoclast differentiation	http://purl.obolibrary.org/obo/GO_0045670	regulation of osteoclast differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.
http://purl.obolibrary.org/obo/GO_0045672	positive regulation of osteoclast differentiation	http://purl.obolibrary.org/obo/GO_0045670	regulation of osteoclast differentiation		Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
http://purl.obolibrary.org/obo/GO_0045682	regulation of epidermis development	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of epidermis development.
http://purl.obolibrary.org/obo/GO_0045683	negative regulation of epidermis development	http://purl.obolibrary.org/obo/GO_0045682	regulation of epidermis development		Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.
http://purl.obolibrary.org/obo/GO_0045684	positive regulation of epidermis development	http://purl.obolibrary.org/obo/GO_0045682	regulation of epidermis development		Any process that activates or increases the frequency, rate or extent of epidermis development.
http://purl.obolibrary.org/obo/GO_0045700	regulation of spermatid nuclear differentiation	http://purl.obolibrary.org/obo/GO_1903353	regulation of nucleus organization		Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation.
http://purl.obolibrary.org/obo/GO_0045701	negative regulation of spermatid nuclear differentiation	http://purl.obolibrary.org/obo/GO_2000242	negative regulation of reproductive process		Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation.
http://purl.obolibrary.org/obo/GO_0045702	positive regulation of spermatid nuclear differentiation	http://purl.obolibrary.org/obo/GO_2000243	positive regulation of reproductive process		Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation.
http://purl.obolibrary.org/obo/GO_0045719	negative regulation of glycogen biosynthetic process	http://purl.obolibrary.org/obo/GO_0070874	negative regulation of glycogen metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
http://purl.obolibrary.org/obo/GO_0045721	negative regulation of gluconeogenesis	http://purl.obolibrary.org/obo/GO_0045912	negative regulation of carbohydrate metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
http://purl.obolibrary.org/obo/GO_0045722	positive regulation of gluconeogenesis	http://purl.obolibrary.org/obo/GO_0010907	positive regulation of glucose metabolic process		Any process that activates or increases the frequency, rate or extent of gluconeogenesis.
http://purl.obolibrary.org/obo/GO_0045724	positive regulation of cilium assembly	http://purl.obolibrary.org/obo/GO_0120034	positive regulation of plasma membrane bounded cell projection assembly		Any process that activates or increases the frequency, rate or extent of the formation of a cilium.
http://purl.obolibrary.org/obo/GO_0045725	positive regulation of glycogen biosynthetic process	http://purl.obolibrary.org/obo/GO_0070875	positive regulation of glycogen metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
http://purl.obolibrary.org/obo/GO_0045728	respiratory burst after phagocytosis	http://purl.obolibrary.org/obo/GO_0002679	respiratory burst involved in defense response		A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.
http://purl.obolibrary.org/obo/GO_0045729	respiratory burst at fertilization	http://purl.obolibrary.org/obo/GO_0045730	respiratory burst		The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes.
http://purl.obolibrary.org/obo/GO_0045745	positive regulation of G protein-coupled receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0008277	regulation of G protein-coupled receptor signaling pathway		Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.
http://purl.obolibrary.org/obo/GO_0045759	negative regulation of action potential	http://purl.obolibrary.org/obo/GO_0098900	regulation of action potential		Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
http://purl.obolibrary.org/obo/GO_0045760	positive regulation of action potential	http://purl.obolibrary.org/obo/GO_0098900	regulation of action potential		Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
http://purl.obolibrary.org/obo/GO_0045766	positive regulation of angiogenesis	http://purl.obolibrary.org/obo/GO_0045765	regulation of angiogenesis		Any process that activates or increases angiogenesis.
http://purl.obolibrary.org/obo/GO_0045779	negative regulation of bone resorption	http://purl.obolibrary.org/obo/GO_0046851	negative regulation of bone remodeling		Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.
http://purl.obolibrary.org/obo/GO_0045780	positive regulation of bone resorption	http://purl.obolibrary.org/obo/GO_0045124	regulation of bone resorption		Any process that activates or increases the frequency, rate or extent of bone resorption.
http://purl.obolibrary.org/obo/GO_0045787	positive regulation of cell cycle	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the rate or extent of progression through the cell cycle.
http://purl.obolibrary.org/obo/GO_0045937	positive regulation of phosphate metabolic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
http://purl.obolibrary.org/obo/GO_0046543	development of animal secondary female sexual characteristics	http://purl.obolibrary.org/obo/GO_0045136	development of animal secondary sexual characteristics		The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female mammals, examples include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.
http://purl.obolibrary.org/obo/GO_0046621	negative regulation of organ growth	http://purl.obolibrary.org/obo/GO_0048640	negative regulation of developmental growth		Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
http://purl.obolibrary.org/obo/GO_0046622	positive regulation of organ growth	http://purl.obolibrary.org/obo/GO_0048639	positive regulation of developmental growth		Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
http://purl.obolibrary.org/obo/GO_0046643	regulation of gamma-delta T cell activation	http://purl.obolibrary.org/obo/GO_0050863	regulation of T cell activation		Any process that modulates the frequency, rate or extent of gamma-delta T cell activation.
http://purl.obolibrary.org/obo/GO_0046644	negative regulation of gamma-delta T cell activation	http://purl.obolibrary.org/obo/GO_0050868	negative regulation of T cell activation		Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation.
http://purl.obolibrary.org/obo/GO_0046645	positive regulation of gamma-delta T cell activation	http://purl.obolibrary.org/obo/GO_0046643	regulation of gamma-delta T cell activation		Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation.
http://purl.obolibrary.org/obo/GO_0046849	bone remodeling	http://purl.obolibrary.org/obo/GO_0048771	tissue remodeling		The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
http://purl.obolibrary.org/obo/GO_0046850	regulation of bone remodeling	http://purl.obolibrary.org/obo/GO_0034103	regulation of tissue remodeling		Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.
http://purl.obolibrary.org/obo/GO_0046851	negative regulation of bone remodeling	http://purl.obolibrary.org/obo/GO_0046850	regulation of bone remodeling		Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.
http://purl.obolibrary.org/obo/GO_0046852	positive regulation of bone remodeling	http://purl.obolibrary.org/obo/GO_0046850	regulation of bone remodeling		Any process that activates or increases the frequency, rate or extent of bone remodeling.
http://purl.obolibrary.org/obo/GO_0046951	ketone body biosynthetic process	http://purl.obolibrary.org/obo/GO_0044283	small molecule biosynthetic process		The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.
http://purl.obolibrary.org/obo/GO_0048103	somatic stem cell division	http://purl.obolibrary.org/obo/GO_0017145	stem cell division		The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.
http://purl.obolibrary.org/obo/GO_0048639	positive regulation of developmental growth	http://purl.obolibrary.org/obo/GO_0048638	regulation of developmental growth		Any process that activates, maintains or increases the rate of developmental growth.
http://purl.obolibrary.org/obo/GO_0048770	pigment granule	http://purl.obolibrary.org/obo/GO_0031410	cytoplasmic vesicle		A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.
http://purl.obolibrary.org/obo/GO_0048799	animal organ maturation	http://purl.obolibrary.org/obo/GO_0071695	anatomical structure maturation		A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.
http://purl.obolibrary.org/obo/GO_0050688	regulation of defense response to virus	http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response		Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
http://purl.obolibrary.org/obo/GO_0050802	circadian sleep/wake cycle, sleep	http://purl.obolibrary.org/obo/GO_0030431	sleep		The part of the circadian sleep/wake cycle where the organism is asleep.
http://purl.obolibrary.org/obo/GO_0050863	regulation of T cell activation	http://purl.obolibrary.org/obo/GO_0051249	regulation of lymphocyte activation		Any process that modulates the frequency, rate or extent of T cell activation.
http://purl.obolibrary.org/obo/GO_0050868	negative regulation of T cell activation	http://purl.obolibrary.org/obo/GO_0050863	regulation of T cell activation		Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
http://purl.obolibrary.org/obo/GO_0051222	positive regulation of protein transport	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051224	negative regulation of protein transport	http://purl.obolibrary.org/obo/GO_1903828	negative regulation of protein localization		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051338	regulation of transferase activity	http://purl.obolibrary.org/obo/GO_0050790	regulation of catalytic activity		Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
http://purl.obolibrary.org/obo/GO_0051351	positive regulation of ligase activity	http://purl.obolibrary.org/obo/GO_0043085	positive regulation of catalytic activity		Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.
http://purl.obolibrary.org/obo/GO_0051445	regulation of meiotic cell cycle	http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process		Any process that modulates the rate or extent of progression through the meiotic cell cycle.
http://purl.obolibrary.org/obo/GO_0051446	positive regulation of meiotic cell cycle	http://purl.obolibrary.org/obo/GO_2000243	positive regulation of reproductive process		Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
http://purl.obolibrary.org/obo/GO_0051447	negative regulation of meiotic cell cycle	http://purl.obolibrary.org/obo/GO_2000242	negative regulation of reproductive process		Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.
http://purl.obolibrary.org/obo/GO_0051930	regulation of sensory perception of pain	http://purl.obolibrary.org/obo/GO_0051931	regulation of sensory perception		Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
http://purl.obolibrary.org/obo/GO_0051969	regulation of transmission of nerve impulse	http://purl.obolibrary.org/obo/GO_0031644	regulation of nervous system process		Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
http://purl.obolibrary.org/obo/GO_0060173	limb development	http://purl.obolibrary.org/obo/GO_0048736	appendage development		The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.
http://purl.obolibrary.org/obo/GO_0060271	cilium assembly	http://purl.obolibrary.org/obo/GO_0120031	plasma membrane bounded cell projection assembly		The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
http://purl.obolibrary.org/obo/GO_0060348	bone development	http://purl.obolibrary.org/obo/GO_0048513	animal organ development		The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
http://purl.obolibrary.org/obo/GO_0060467	negative regulation of fertilization	http://purl.obolibrary.org/obo/GO_2000242	negative regulation of reproductive process		Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
http://purl.obolibrary.org/obo/GO_0070293	renal absorption	http://purl.obolibrary.org/obo/GO_0003014	renal system process		A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).
http://purl.obolibrary.org/obo/GO_0070295	renal water absorption	http://purl.obolibrary.org/obo/GO_0070293	renal absorption		A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
http://purl.obolibrary.org/obo/GO_0070874	negative regulation of glycogen metabolic process	http://purl.obolibrary.org/obo/GO_0045912	negative regulation of carbohydrate metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen.
http://purl.obolibrary.org/obo/GO_0070875	positive regulation of glycogen metabolic process	http://purl.obolibrary.org/obo/GO_0010907	positive regulation of glucose metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen.
http://purl.obolibrary.org/obo/GO_0070977	bone maturation	http://purl.obolibrary.org/obo/GO_0048799	animal organ maturation		A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.
http://purl.obolibrary.org/obo/GO_0071692	protein localization to extracellular region	http://purl.obolibrary.org/obo/GO_0033036	macromolecule localization		Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location.
http://purl.obolibrary.org/obo/GO_0080154	regulation of fertilization	http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process		Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion	http://purl.obolibrary.org/obo/GO_0002791	regulation of peptide secretion		Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
http://purl.obolibrary.org/obo/GO_0090316	positive regulation of intracellular protein transport	http://purl.obolibrary.org/obo/GO_0051222	positive regulation of protein transport		Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
http://purl.obolibrary.org/obo/GO_0090317	negative regulation of intracellular protein transport	http://purl.obolibrary.org/obo/GO_0051224	negative regulation of protein transport		Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
http://purl.obolibrary.org/obo/GO_0090330	regulation of platelet aggregation	http://purl.obolibrary.org/obo/GO_0010543	regulation of platelet activation		Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
http://purl.obolibrary.org/obo/GO_0090331	negative regulation of platelet aggregation	http://purl.obolibrary.org/obo/GO_0010544	negative regulation of platelet activation		Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
http://purl.obolibrary.org/obo/GO_0097237	cellular response to toxic substance	http://purl.obolibrary.org/obo/GO_0009636	response to toxic substance		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
http://purl.obolibrary.org/obo/GO_0098794	postsynapse	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The part of a synapse that is part of the post-synaptic cell.
http://purl.obolibrary.org/obo/GO_0098803	respiratory chain complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		Any protein complex that is part of a respiratory chain.
http://purl.obolibrary.org/obo/GO_1900116	extracellular negative regulation of signal transduction	http://purl.obolibrary.org/obo/GO_1900115	extracellular regulation of signal transduction		Any negative regulation of signal transduction that takes place in extracellular region.
http://purl.obolibrary.org/obo/GO_1901342	regulation of vasculature development	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of vasculature development.
http://purl.obolibrary.org/obo/GO_1901655	cellular response to ketone	http://purl.obolibrary.org/obo/GO_1901701	cellular response to oxygen-containing compound		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus.
http://purl.obolibrary.org/obo/GO_1901701	cellular response to oxygen-containing compound	http://purl.obolibrary.org/obo/GO_1901700	response to oxygen-containing compound		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.
http://purl.obolibrary.org/obo/GO_1901731	positive regulation of platelet aggregation	http://purl.obolibrary.org/obo/GO_0090330	regulation of platelet aggregation		Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
http://purl.obolibrary.org/obo/GO_1902017	regulation of cilium assembly	http://purl.obolibrary.org/obo/GO_0120032	regulation of plasma membrane bounded cell projection assembly		Any process that modulates the frequency, rate or extent of cilium assembly.
http://purl.obolibrary.org/obo/GO_1903306	negative regulation of regulated secretory pathway	http://purl.obolibrary.org/obo/GO_1903305	regulation of regulated secretory pathway		Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway.
http://purl.obolibrary.org/obo/GO_1903307	positive regulation of regulated secretory pathway	http://purl.obolibrary.org/obo/GO_1903305	regulation of regulated secretory pathway		Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
http://purl.obolibrary.org/obo/GO_1903706	regulation of hemopoiesis	http://purl.obolibrary.org/obo/GO_0060284	regulation of cell development		Any process that modulates the frequency, rate or extent of hemopoiesis.
http://purl.obolibrary.org/obo/GO_1903707	negative regulation of hemopoiesis	http://purl.obolibrary.org/obo/GO_0010721	negative regulation of cell development		Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.
http://purl.obolibrary.org/obo/GO_1903708	positive regulation of hemopoiesis	http://purl.obolibrary.org/obo/GO_0010720	positive regulation of cell development		Any process that activates or increases the frequency, rate or extent of hemopoiesis.
http://purl.obolibrary.org/obo/GO_1903729	regulation of plasma membrane organization	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of plasma membrane organization.
http://purl.obolibrary.org/obo/GO_1903998	regulation of eating behavior	http://purl.obolibrary.org/obo/GO_0060259	regulation of feeding behavior		Any process that modulates the frequency, rate or extent of eating behavior.
http://purl.obolibrary.org/obo/GO_1904018	positive regulation of vasculature development	http://purl.obolibrary.org/obo/GO_1901342	regulation of vasculature development		Any process that activates or increases the frequency, rate or extent of vasculature development.
http://purl.obolibrary.org/obo/GO_1990777	lipoprotein particle	http://purl.obolibrary.org/obo/GO_0032994	protein-lipid complex		A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph.
http://purl.obolibrary.org/obo/GO_2000383	regulation of ectoderm development	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of ectoderm development.
http://purl.obolibrary.org/obo/GO_2000384	negative regulation of ectoderm development	http://purl.obolibrary.org/obo/GO_2000383	regulation of ectoderm development		Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.
http://purl.obolibrary.org/obo/GO_2000542	negative regulation of gastrulation	http://purl.obolibrary.org/obo/GO_0010470	regulation of gastrulation		Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.
http://purl.obolibrary.org/obo/GO_2000881	regulation of starch catabolic process	http://purl.obolibrary.org/obo/GO_2000904	regulation of starch metabolic process		Any process that modulates the frequency, rate or extent of starch catabolic process.
http://purl.obolibrary.org/obo/GO_2000883	positive regulation of starch catabolic process	http://purl.obolibrary.org/obo/GO_0045913	positive regulation of carbohydrate metabolic process		Any process that activates or increases the frequency, rate or extent of starch catabolic process.
http://purl.obolibrary.org/obo/GO_0086103	G protein-coupled receptor signaling pathway involved in heart process	http://purl.obolibrary.org/obo/GO_0007186	G protein-coupled receptor signaling pathway		An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.
http://purl.obolibrary.org/obo/GO_0090022	regulation of neutrophil chemotaxis	http://purl.obolibrary.org/obo/GO_0071622	regulation of granulocyte chemotaxis		Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
http://purl.obolibrary.org/obo/GO_0090023	positive regulation of neutrophil chemotaxis	http://purl.obolibrary.org/obo/GO_0071624	positive regulation of granulocyte chemotaxis		Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
http://purl.obolibrary.org/obo/GO_0090024	negative regulation of neutrophil chemotaxis	http://purl.obolibrary.org/obo/GO_0071623	negative regulation of granulocyte chemotaxis		Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
http://purl.obolibrary.org/obo/GO_0090025	regulation of monocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0071675	regulation of mononuclear cell migration		Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.
http://purl.obolibrary.org/obo/GO_0090026	positive regulation of monocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0071677	positive regulation of mononuclear cell migration		Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
http://purl.obolibrary.org/obo/GO_0090027	negative regulation of monocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0071676	negative regulation of mononuclear cell migration		Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.
http://purl.obolibrary.org/obo/GO_0090139	mitochondrial chromosome packaging	http://purl.obolibrary.org/obo/GO_0051276	chromosome organization		A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure.
http://purl.obolibrary.org/obo/GO_0090273	regulation of somatostatin secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
http://purl.obolibrary.org/obo/GO_0090274	positive regulation of somatostatin secretion	http://purl.obolibrary.org/obo/GO_0090273	regulation of somatostatin secretion		Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
http://purl.obolibrary.org/obo/GO_0090275	negative regulation of somatostatin secretion	http://purl.obolibrary.org/obo/GO_0090273	regulation of somatostatin secretion		Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
http://purl.obolibrary.org/obo/GO_0090325	regulation of locomotion involved in locomotory behavior	http://purl.obolibrary.org/obo/GO_0040012	regulation of locomotion		Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
http://purl.obolibrary.org/obo/GO_0090326	positive regulation of locomotion involved in locomotory behavior	http://purl.obolibrary.org/obo/GO_0048520	positive regulation of behavior		Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
http://purl.obolibrary.org/obo/GO_0090327	negative regulation of locomotion involved in locomotory behavior	http://purl.obolibrary.org/obo/GO_0090325	regulation of locomotion involved in locomotory behavior		Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
http://purl.obolibrary.org/obo/GO_0090394	negative regulation of excitatory postsynaptic potential	http://purl.obolibrary.org/obo/GO_0098815	modulation of excitatory postsynaptic potential		Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
http://purl.obolibrary.org/obo/GO_0090713	immunological memory process	http://purl.obolibrary.org/obo/GO_0002376	immune system process		Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory.
http://purl.obolibrary.org/obo/GO_0097208	alveolar lamellar body	http://purl.obolibrary.org/obo/GO_0042599	lamellar body		A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
http://purl.obolibrary.org/obo/GO_0097238	cellular response to methylglyoxal	http://purl.obolibrary.org/obo/GO_0110096	cellular response to aldehyde		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.
http://purl.obolibrary.org/obo/GO_0097254	renal tubular secretion	http://purl.obolibrary.org/obo/GO_0003014	renal system process		The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.
http://purl.obolibrary.org/obo/GO_0097447	dendritic tree	http://purl.obolibrary.org/obo/GO_0043005	neuron projection		The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.
http://purl.obolibrary.org/obo/GO_0097742	de novo centriole assembly	http://purl.obolibrary.org/obo/GO_0098534	centriole assembly		Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects.
http://purl.obolibrary.org/obo/GO_0098535	de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0097742	de novo centriole assembly		Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation.
http://purl.obolibrary.org/obo/GO_0098594	mucin granule	http://purl.obolibrary.org/obo/GO_0030141	secretory granule		A secretory granule that contains mucin.
http://purl.obolibrary.org/obo/GO_0098644	complex of collagen trimers	http://purl.obolibrary.org/obo/GO_0099080	supramolecular complex		A complex of collagen trimers such as a fibril or collagen network.
http://purl.obolibrary.org/obo/GO_0098871	postsynaptic actin cytoskeleton	http://purl.obolibrary.org/obo/GO_0099571	postsynaptic cytoskeleton		The actin cytoskeleton that is part of a postsynapse.
http://purl.obolibrary.org/obo/GO_0098976	excitatory chemical synaptic transmission	http://purl.obolibrary.org/obo/GO_0007268	chemical synaptic transmission		Synaptic transmission that results in an excitatory postsynaptic potential.
http://purl.obolibrary.org/obo/GO_0099081	supramolecular polymer	http://purl.obolibrary.org/obo/GO_0099080	supramolecular complex		A polymeric supramolecular structure.
http://purl.obolibrary.org/obo/GO_0099530	G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential	http://purl.obolibrary.org/obo/GO_0004930	G protein-coupled receptor activity		A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane.
http://purl.obolibrary.org/obo/GO_0099536	synaptic signaling	http://purl.obolibrary.org/obo/GO_0007267	cell-cell signaling		Cell-cell signaling to, from or within a synapse.
http://purl.obolibrary.org/obo/GO_0099537	trans-synaptic signaling	http://purl.obolibrary.org/obo/GO_0099536	synaptic signaling		Cell-cell signaling in either direction across the synaptic cleft.
http://purl.obolibrary.org/obo/GO_0099547	regulation of translation at synapse, modulating synaptic transmission	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process that modulates synaptic transmission by regulating translation occurring at the synapse.
http://purl.obolibrary.org/obo/GO_0099550	trans-synaptic signaling, modulating synaptic transmission	http://purl.obolibrary.org/obo/GO_0099537	trans-synaptic signaling		Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.
http://purl.obolibrary.org/obo/GO_0099571	postsynaptic cytoskeleton	http://purl.obolibrary.org/obo/GO_0005856	cytoskeleton		The portion of the cytoskeleton contained within the postsynapse.
http://purl.obolibrary.org/obo/GO_0099577	regulation of translation at presynapse, modulating synaptic transmission	http://purl.obolibrary.org/obo/GO_0140244	regulation of translation at presynapse		Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
http://purl.obolibrary.org/obo/GO_0099578	regulation of translation at postsynapse, modulating synaptic transmission	http://purl.obolibrary.org/obo/GO_0099170	postsynaptic modulation of chemical synaptic transmission		Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
http://purl.obolibrary.org/obo/GO_1900015	regulation of cytokine production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0001817	regulation of cytokine production		Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
http://purl.obolibrary.org/obo/GO_1900016	negative regulation of cytokine production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_1900015	regulation of cytokine production involved in inflammatory response		Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
http://purl.obolibrary.org/obo/GO_1900017	positive regulation of cytokine production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_1900015	regulation of cytokine production involved in inflammatory response		Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
http://purl.obolibrary.org/obo/GO_1900073	regulation of neuromuscular synaptic transmission	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission.
http://purl.obolibrary.org/obo/GO_1900074	negative regulation of neuromuscular synaptic transmission	http://purl.obolibrary.org/obo/GO_1900073	regulation of neuromuscular synaptic transmission		Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission.
http://purl.obolibrary.org/obo/GO_1900075	positive regulation of neuromuscular synaptic transmission	http://purl.obolibrary.org/obo/GO_1900073	regulation of neuromuscular synaptic transmission		Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission.
http://purl.obolibrary.org/obo/GO_1900115	extracellular regulation of signal transduction	http://purl.obolibrary.org/obo/GO_0009966	regulation of signal transduction		Any regulation of signal transduction that takes place in the extracellular region.
http://purl.obolibrary.org/obo/GO_1900117	regulation of execution phase of apoptosis	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of execution phase of apoptosis.
http://purl.obolibrary.org/obo/GO_1900118	negative regulation of execution phase of apoptosis	http://purl.obolibrary.org/obo/GO_1900117	regulation of execution phase of apoptosis		Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
http://purl.obolibrary.org/obo/GO_1900119	positive regulation of execution phase of apoptosis	http://purl.obolibrary.org/obo/GO_0043065	positive regulation of apoptotic process		Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.
http://purl.obolibrary.org/obo/GO_1900158	negative regulation of bone mineralization involved in bone maturation	http://purl.obolibrary.org/obo/GO_0030502	negative regulation of bone mineralization		Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation.
http://purl.obolibrary.org/obo/GO_1900159	positive regulation of bone mineralization involved in bone maturation	http://purl.obolibrary.org/obo/GO_0030501	positive regulation of bone mineralization		Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation.
http://purl.obolibrary.org/obo/GO_1901148	gene expression involved in extracellular matrix organization	http://purl.obolibrary.org/obo/GO_0010467	gene expression		Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form.
http://purl.obolibrary.org/obo/GO_1901190	regulation of formation of translation initiation ternary complex	http://purl.obolibrary.org/obo/GO_0043254	regulation of protein-containing complex assembly		Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex.
http://purl.obolibrary.org/obo/GO_1901191	negative regulation of formation of translation initiation ternary complex	http://purl.obolibrary.org/obo/GO_1901190	regulation of formation of translation initiation ternary complex		Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.
http://purl.obolibrary.org/obo/GO_1901192	positive regulation of formation of translation initiation ternary complex	http://purl.obolibrary.org/obo/GO_1901190	regulation of formation of translation initiation ternary complex		Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex.
http://purl.obolibrary.org/obo/GO_1901858	regulation of mitochondrial DNA metabolic process	http://purl.obolibrary.org/obo/GO_0051052	regulation of DNA metabolic process		Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process.
http://purl.obolibrary.org/obo/GO_1901859	negative regulation of mitochondrial DNA metabolic process	http://purl.obolibrary.org/obo/GO_1901858	regulation of mitochondrial DNA metabolic process		Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process.
http://purl.obolibrary.org/obo/GO_1901860	positive regulation of mitochondrial DNA metabolic process	http://purl.obolibrary.org/obo/GO_0010821	regulation of mitochondrion organization		Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process.
http://purl.obolibrary.org/obo/GO_1902622	regulation of neutrophil migration	http://purl.obolibrary.org/obo/GO_0002685	regulation of leukocyte migration		Any process that modulates the frequency, rate or extent of neutrophil migration.
http://purl.obolibrary.org/obo/GO_1902623	negative regulation of neutrophil migration	http://purl.obolibrary.org/obo/GO_1902622	regulation of neutrophil migration		Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration.
http://purl.obolibrary.org/obo/GO_1902624	positive regulation of neutrophil migration	http://purl.obolibrary.org/obo/GO_1902622	regulation of neutrophil migration		Any process that activates or increases the frequency, rate or extent of neutrophil migration.
http://purl.obolibrary.org/obo/GO_1903011	negative regulation of bone development	http://purl.obolibrary.org/obo/GO_1903010	regulation of bone development		Any process that stops, prevents or reduces the frequency, rate or extent of bone development.
http://purl.obolibrary.org/obo/GO_1903012	positive regulation of bone development	http://purl.obolibrary.org/obo/GO_1903010	regulation of bone development		Any process that activates or increases the frequency, rate or extent of bone development.
http://purl.obolibrary.org/obo/GO_1903251	multi-ciliated epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0002065	columnar/cuboidal epithelial cell differentiation		The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell.
http://purl.obolibrary.org/obo/GO_1903327	negative regulation of tRNA metabolic process	http://purl.obolibrary.org/obo/GO_1903326	regulation of tRNA metabolic process		Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process.
http://purl.obolibrary.org/obo/GO_1903829	positive regulation of protein localization	http://purl.obolibrary.org/obo/GO_0032880	regulation of protein localization		Any process that activates or increases the frequency, rate or extent of a protein localization.
http://purl.obolibrary.org/obo/GO_2000380	regulation of mesoderm development	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of mesoderm development.
http://purl.obolibrary.org/obo/GO_2000381	negative regulation of mesoderm development	http://purl.obolibrary.org/obo/GO_2000380	regulation of mesoderm development		Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.
http://purl.obolibrary.org/obo/GO_2000382	positive regulation of mesoderm development	http://purl.obolibrary.org/obo/GO_2000380	regulation of mesoderm development		Any process that activates or increases the frequency, rate or extent of mesoderm development.
http://purl.obolibrary.org/obo/GO_2001233	regulation of apoptotic signaling pathway	http://purl.obolibrary.org/obo/GO_0042981	regulation of apoptotic process		Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.
http://purl.obolibrary.org/obo/GO_2001234	negative regulation of apoptotic signaling pathway	http://purl.obolibrary.org/obo/GO_2001233	regulation of apoptotic signaling pathway		Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.
http://purl.obolibrary.org/obo/GO_2001235	positive regulation of apoptotic signaling pathway	http://purl.obolibrary.org/obo/GO_0043065	positive regulation of apoptotic process		Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
http://purl.obolibrary.org/obo/GO_1901317	regulation of flagellated sperm motility	http://purl.obolibrary.org/obo/GO_0060295	regulation of cilium movement involved in cell motility		Any process that modulates the frequency, rate or extent of flagellated sperm motility.
http://purl.obolibrary.org/obo/GO_1901318	negative regulation of flagellated sperm motility	http://purl.obolibrary.org/obo/GO_2000242	negative regulation of reproductive process		Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility.
http://purl.obolibrary.org/obo/GO_1901532	regulation of hematopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_0045595	regulation of cell differentiation		Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.
http://purl.obolibrary.org/obo/GO_1901533	negative regulation of hematopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1901532	regulation of hematopoietic progenitor cell differentiation		Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.
http://purl.obolibrary.org/obo/GO_1901534	positive regulation of hematopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_0045597	positive regulation of cell differentiation		Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.
http://purl.obolibrary.org/obo/GO_1901738	regulation of vitamin A metabolic process	http://purl.obolibrary.org/obo/GO_0019747	regulation of isoprenoid metabolic process		Any process that modulates the frequency, rate or extent of vitamin A metabolic process.
http://purl.obolibrary.org/obo/GO_1902018	negative regulation of cilium assembly	http://purl.obolibrary.org/obo/GO_0120033	negative regulation of plasma membrane bounded cell projection assembly		Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.
http://purl.obolibrary.org/obo/GO_1902020	negative regulation of cilium-dependent cell motility	http://purl.obolibrary.org/obo/GO_1902019	regulation of cilium-dependent cell motility		Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility.
http://purl.obolibrary.org/obo/GO_1902262	apoptotic process involved in blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_0060561	apoptotic process involved in morphogenesis		Any apoptotic process that is involved in blood vessel morphogenesis.
http://purl.obolibrary.org/obo/GO_1902340	negative regulation of chromosome condensation	http://purl.obolibrary.org/obo/GO_0060623	regulation of chromosome condensation		Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.
http://purl.obolibrary.org/obo/GO_1902490	regulation of sperm capacitation	http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process		Any process that modulates the frequency, rate or extent of sperm capacitation.
http://purl.obolibrary.org/obo/GO_1902491	negative regulation of sperm capacitation	http://purl.obolibrary.org/obo/GO_2000242	negative regulation of reproductive process		Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation.
http://purl.obolibrary.org/obo/GO_1902492	positive regulation of sperm capacitation	http://purl.obolibrary.org/obo/GO_2000243	positive regulation of reproductive process		Any process that activates or increases the frequency, rate or extent of sperm capacitation.
http://purl.obolibrary.org/obo/GO_1902721	negative regulation of prolactin secretion	http://purl.obolibrary.org/obo/GO_0090278	negative regulation of peptide hormone secretion		Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion.
http://purl.obolibrary.org/obo/GO_1902722	positive regulation of prolactin secretion	http://purl.obolibrary.org/obo/GO_0090277	positive regulation of peptide hormone secretion		Any process that activates or increases the frequency, rate or extent of prolactin secretion.
http://purl.obolibrary.org/obo/GO_1903294	regulation of glutamate secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0051966	regulation of synaptic transmission, glutamatergic		Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission.
http://purl.obolibrary.org/obo/GO_1903295	negative regulation of glutamate secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0051967	negative regulation of synaptic transmission, glutamatergic		Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission.
http://purl.obolibrary.org/obo/GO_1903326	regulation of tRNA metabolic process	http://purl.obolibrary.org/obo/GO_0051252	regulation of RNA metabolic process		Any process that modulates the frequency, rate or extent of tRNA metabolic process.
http://purl.obolibrary.org/obo/GO_1903328	positive regulation of tRNA metabolic process	http://purl.obolibrary.org/obo/GO_1903326	regulation of tRNA metabolic process		Any process that activates or increases the frequency, rate or extent of tRNA metabolic process.
http://purl.obolibrary.org/obo/GO_1903379	regulation of mitotic chromosome condensation	http://purl.obolibrary.org/obo/GO_0060623	regulation of chromosome condensation		Any process that modulates the frequency, rate or extent of mitotic chromosome condensation.
http://purl.obolibrary.org/obo/GO_1903380	positive regulation of mitotic chromosome condensation	http://purl.obolibrary.org/obo/GO_0090068	positive regulation of cell cycle process		Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation.
http://purl.obolibrary.org/obo/GO_1903487	regulation of lactation	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of lactation.
http://purl.obolibrary.org/obo/GO_1903488	negative regulation of lactation	http://purl.obolibrary.org/obo/GO_1903487	regulation of lactation		Any process that stops, prevents or reduces the frequency, rate or extent of lactation.
http://purl.obolibrary.org/obo/GO_1903551	regulation of extracellular exosome assembly	http://purl.obolibrary.org/obo/GO_1902115	regulation of organelle assembly		Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.
http://purl.obolibrary.org/obo/GO_1903552	negative regulation of extracellular exosome assembly	http://purl.obolibrary.org/obo/GO_1902116	negative regulation of organelle assembly		Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly.
http://purl.obolibrary.org/obo/GO_1903553	positive regulation of extracellular exosome assembly	http://purl.obolibrary.org/obo/GO_1902117	positive regulation of organelle assembly		Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.
http://purl.obolibrary.org/obo/GO_1903564	regulation of protein localization to cilium	http://purl.obolibrary.org/obo/GO_0032880	regulation of protein localization		Any process that modulates the frequency, rate or extent of protein localization to cilium.
http://purl.obolibrary.org/obo/GO_1903565	negative regulation of protein localization to cilium	http://purl.obolibrary.org/obo/GO_1903828	negative regulation of protein localization		Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.
http://purl.obolibrary.org/obo/GO_1903566	positive regulation of protein localization to cilium	http://purl.obolibrary.org/obo/GO_1903564	regulation of protein localization to cilium		Any process that activates or increases the frequency, rate or extent of protein localization to cilium.
http://purl.obolibrary.org/obo/GO_1905821	positive regulation of chromosome condensation	http://purl.obolibrary.org/obo/GO_0060623	regulation of chromosome condensation		Any process that activates or increases the frequency, rate or extent of chromosome condensation.
http://purl.obolibrary.org/obo/GO_1905747	negative regulation of saliva secretion	http://purl.obolibrary.org/obo/GO_0060457	negative regulation of digestive system process		Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion.
http://purl.obolibrary.org/obo/GO_1905788	negative regulation of detection of mechanical stimulus involved in sensory perception of touch	http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus		Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch.
http://purl.obolibrary.org/obo/GO_1905789	positive regulation of detection of mechanical stimulus involved in sensory perception of touch	http://purl.obolibrary.org/obo/GO_0031646	positive regulation of nervous system process		Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch.
http://purl.obolibrary.org/obo/GO_1905902	regulation of mesoderm formation	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of mesoderm formation.
http://purl.obolibrary.org/obo/GO_1905903	negative regulation of mesoderm formation	http://purl.obolibrary.org/obo/GO_1905902	regulation of mesoderm formation		Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation.
http://purl.obolibrary.org/obo/GO_1905904	positive regulation of mesoderm formation	http://purl.obolibrary.org/obo/GO_1905902	regulation of mesoderm formation		Any process that activates or increases the frequency, rate or extent of mesoderm formation.
http://purl.obolibrary.org/obo/GO_2000155	positive regulation of cilium-dependent cell motility	http://purl.obolibrary.org/obo/GO_1902019	regulation of cilium-dependent cell motility		Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.
http://purl.obolibrary.org/obo/GO_2000260	regulation of blood coagulation, common pathway	http://purl.obolibrary.org/obo/GO_0030193	regulation of blood coagulation		Any process that modulates the frequency, rate or extent of blood coagulation, common pathway.
http://purl.obolibrary.org/obo/GO_2000261	negative regulation of blood coagulation, common pathway	http://purl.obolibrary.org/obo/GO_0030195	negative regulation of blood coagulation		Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway.
http://purl.obolibrary.org/obo/GO_2000262	positive regulation of blood coagulation, common pathway	http://purl.obolibrary.org/obo/GO_2000260	regulation of blood coagulation, common pathway		Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway.
http://purl.obolibrary.org/obo/GO_2000263	regulation of blood coagulation, extrinsic pathway	http://purl.obolibrary.org/obo/GO_0030193	regulation of blood coagulation		Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway.
http://purl.obolibrary.org/obo/GO_2000264	negative regulation of blood coagulation, extrinsic pathway	http://purl.obolibrary.org/obo/GO_0030195	negative regulation of blood coagulation		Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway.
http://purl.obolibrary.org/obo/GO_2000265	positive regulation of blood coagulation, extrinsic pathway	http://purl.obolibrary.org/obo/GO_2000263	regulation of blood coagulation, extrinsic pathway		Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway.
http://purl.obolibrary.org/obo/GO_2000266	regulation of blood coagulation, intrinsic pathway	http://purl.obolibrary.org/obo/GO_0030193	regulation of blood coagulation		Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway.
http://purl.obolibrary.org/obo/GO_2000267	negative regulation of blood coagulation, intrinsic pathway	http://purl.obolibrary.org/obo/GO_0030195	negative regulation of blood coagulation		Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway.
http://purl.obolibrary.org/obo/GO_2000268	positive regulation of blood coagulation, intrinsic pathway	http://purl.obolibrary.org/obo/GO_2000266	regulation of blood coagulation, intrinsic pathway		Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway.
http://purl.obolibrary.org/obo/GO_2000292	regulation of defecation	http://purl.obolibrary.org/obo/GO_0044062	regulation of excretion		Any process that modulates the frequency, rate or extent of defecation.
http://purl.obolibrary.org/obo/GO_2000293	negative regulation of defecation	http://purl.obolibrary.org/obo/GO_0060457	negative regulation of digestive system process		Any process that stops, prevents or reduces the frequency, rate or extent of defecation.
http://purl.obolibrary.org/obo/GO_2000294	positive regulation of defecation	http://purl.obolibrary.org/obo/GO_2000292	regulation of defecation		Any process that activates or increases the frequency, rate or extent of defecation.
http://purl.obolibrary.org/obo/GO_2000385	positive regulation of ectoderm development	http://purl.obolibrary.org/obo/GO_2000383	regulation of ectoderm development		Any process that activates or increases the frequency, rate or extent of ectoderm development.
http://purl.obolibrary.org/obo/GO_2000463	positive regulation of excitatory postsynaptic potential	http://purl.obolibrary.org/obo/GO_0098815	modulation of excitatory postsynaptic potential		Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
http://purl.obolibrary.org/obo/GO_2000609	regulation of thyroid hormone generation	http://purl.obolibrary.org/obo/GO_0032350	regulation of hormone metabolic process		Any process that modulates the frequency, rate or extent of thyroid hormone generation.
http://purl.obolibrary.org/obo/GO_2000610	negative regulation of thyroid hormone generation	http://purl.obolibrary.org/obo/GO_2000609	regulation of thyroid hormone generation		Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation.
http://purl.obolibrary.org/obo/GO_2000611	positive regulation of thyroid hormone generation	http://purl.obolibrary.org/obo/GO_2000609	regulation of thyroid hormone generation		Any process that activates or increases the frequency, rate or extent of thyroid hormone generation.
http://purl.obolibrary.org/obo/GO_2000612	regulation of thyroid-stimulating hormone secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion.
http://purl.obolibrary.org/obo/GO_2000613	negative regulation of thyroid-stimulating hormone secretion	http://purl.obolibrary.org/obo/GO_2000612	regulation of thyroid-stimulating hormone secretion		Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion.
http://purl.obolibrary.org/obo/GO_2000614	positive regulation of thyroid-stimulating hormone secretion	http://purl.obolibrary.org/obo/GO_2000612	regulation of thyroid-stimulating hormone secretion		Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion.
http://purl.obolibrary.org/obo/GO_2000791	negative regulation of mesenchymal cell proliferation involved in lung development	http://purl.obolibrary.org/obo/GO_0072201	negative regulation of mesenchymal cell proliferation		Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.
http://purl.obolibrary.org/obo/GO_2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_2000794	regulation of epithelial cell proliferation involved in lung morphogenesis		Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.
http://purl.obolibrary.org/obo/GO_2000828	regulation of parathyroid hormone secretion	http://purl.obolibrary.org/obo/GO_0046883	regulation of hormone secretion		Any process that modulates the frequency, rate or extent of parathyroid hormone secretion.
http://purl.obolibrary.org/obo/GO_2000829	negative regulation of parathyroid hormone secretion	http://purl.obolibrary.org/obo/GO_2000828	regulation of parathyroid hormone secretion		Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion.
http://purl.obolibrary.org/obo/GO_2000830	positive regulation of parathyroid hormone secretion	http://purl.obolibrary.org/obo/GO_2000828	regulation of parathyroid hormone secretion		Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion.
http://purl.obolibrary.org/obo/GO_2000834	regulation of androgen secretion	http://purl.obolibrary.org/obo/GO_2000831	regulation of steroid hormone secretion		Any process that modulates the frequency, rate or extent of androgen secretion.
http://purl.obolibrary.org/obo/GO_2000835	negative regulation of androgen secretion	http://purl.obolibrary.org/obo/GO_2000834	regulation of androgen secretion		Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.
http://purl.obolibrary.org/obo/GO_2000836	positive regulation of androgen secretion	http://purl.obolibrary.org/obo/GO_2000834	regulation of androgen secretion		Any process that activates or increases the frequency, rate or extent of androgen secretion.
http://purl.obolibrary.org/obo/GO_2000843	regulation of testosterone secretion	http://purl.obolibrary.org/obo/GO_0046883	regulation of hormone secretion		Any process that modulates the frequency, rate or extent of testosterone secretion.
http://purl.obolibrary.org/obo/GO_2000844	negative regulation of testosterone secretion	http://purl.obolibrary.org/obo/GO_2000843	regulation of testosterone secretion		Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion.
http://purl.obolibrary.org/obo/GO_2000845	positive regulation of testosterone secretion	http://purl.obolibrary.org/obo/GO_2000843	regulation of testosterone secretion		Any process that activates or increases the frequency, rate or extent of testosterone secretion.
http://purl.obolibrary.org/obo/GO_2000846	regulation of corticosteroid hormone secretion	http://purl.obolibrary.org/obo/GO_2000831	regulation of steroid hormone secretion		Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion.
http://purl.obolibrary.org/obo/GO_2000847	negative regulation of corticosteroid hormone secretion	http://purl.obolibrary.org/obo/GO_2000846	regulation of corticosteroid hormone secretion		Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion.
http://purl.obolibrary.org/obo/GO_2000848	positive regulation of corticosteroid hormone secretion	http://purl.obolibrary.org/obo/GO_2000846	regulation of corticosteroid hormone secretion		Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion.
http://purl.obolibrary.org/obo/GO_2000855	regulation of mineralocorticoid secretion	http://purl.obolibrary.org/obo/GO_2000846	regulation of corticosteroid hormone secretion		Any process that modulates the frequency, rate or extent of mineralocorticoid secretion.
http://purl.obolibrary.org/obo/GO_2000856	negative regulation of mineralocorticoid secretion	http://purl.obolibrary.org/obo/GO_2000855	regulation of mineralocorticoid secretion		Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion.
http://purl.obolibrary.org/obo/GO_2000857	positive regulation of mineralocorticoid secretion	http://purl.obolibrary.org/obo/GO_2000855	regulation of mineralocorticoid secretion		Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion.
http://purl.obolibrary.org/obo/GO_2000859	negative regulation of aldosterone secretion	http://purl.obolibrary.org/obo/GO_2000856	negative regulation of mineralocorticoid secretion		Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion.
http://purl.obolibrary.org/obo/GO_2000860	positive regulation of aldosterone secretion	http://purl.obolibrary.org/obo/GO_2000857	positive regulation of mineralocorticoid secretion		Any process that activates or increases the frequency, rate or extent of aldosterone secretion.
http://purl.obolibrary.org/obo/GO_2000882	negative regulation of starch catabolic process	http://purl.obolibrary.org/obo/GO_0045912	negative regulation of carbohydrate metabolic process		Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process.
http://purl.obolibrary.org/obo/GO_2001151	regulation of renal water transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of renal water transport.
http://purl.obolibrary.org/obo/GO_2001152	negative regulation of renal water transport	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport.
http://purl.obolibrary.org/obo/GO_2001153	positive regulation of renal water transport	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of renal water transport.
http://purl.obolibrary.org/obo/GO_2001198	regulation of dendritic cell differentiation	http://purl.obolibrary.org/obo/GO_1902105	regulation of leukocyte differentiation		Any process that modulates the frequency, rate or extent of dendritic cell differentiation.
http://purl.obolibrary.org/obo/GO_2001199	negative regulation of dendritic cell differentiation	http://purl.obolibrary.org/obo/GO_2001198	regulation of dendritic cell differentiation		Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.
http://purl.obolibrary.org/obo/GO_2001200	positive regulation of dendritic cell differentiation	http://purl.obolibrary.org/obo/GO_2001198	regulation of dendritic cell differentiation		Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.
http://purl.obolibrary.org/obo/PR_000000030	thrombospondin subgroup B	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that has a core domain composition consisting of three or four EGF-type repeats, a series of seven contiguous calcium-binding repeats (the thrombospondin type 3 repeats), and a globular carboxyl-terminal domain.
http://purl.obolibrary.org/obo/PR_000000085	cartilage oligomeric matrix protein	http://purl.obolibrary.org/obo/PR_000000030	thrombospondin subgroup B		A thrombospondin subgroup B that is a translation product of the human COMP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001002	CD19 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction.
http://purl.obolibrary.org/obo/PR_000001003	CD34 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved.
http://purl.obolibrary.org/obo/PR_000001005	integrin alpha with A domain	http://purl.obolibrary.org/obo/PR_000025796	integrin alpha		An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000001006	receptor-type tyrosine-protein phosphatase C	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.
http://purl.obolibrary.org/obo/PR_000001012	integrin alpha-M	http://purl.obolibrary.org/obo/PR_000001005	integrin alpha with A domain		An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1.
http://purl.obolibrary.org/obo/PR_000001013	integrin alpha-X	http://purl.obolibrary.org/obo/PR_000001005	integrin alpha with A domain		An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
http://purl.obolibrary.org/obo/PR_000001014	receptor-type tyrosine-protein phosphatase C isoform CD45RABC	http://purl.obolibrary.org/obo/PR_000001006	receptor-type tyrosine-protein phosphatase C		A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001015	receptor-type tyrosine-protein phosphatase C isoform CD45RA	http://purl.obolibrary.org/obo/PR_000050216	receptor-type tyrosine-protein phosphatase C isoform CD45R		A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001017	receptor-type tyrosine-protein phosphatase C isoform CD45RO	http://purl.obolibrary.org/obo/PR_000001006	receptor-type tyrosine-protein phosphatase C		A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-4 or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001020	CD3 epsilon	http://purl.obolibrary.org/obo/PR_000001018	CD3 subunit with immunoglobulin domain		A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001022	neural cell adhesion molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain.
http://purl.obolibrary.org/obo/PR_000001023	neural cell adhesion molecule NCAM	http://purl.obolibrary.org/obo/PR_000001022	neural cell adhesion molecule		A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration.
http://purl.obolibrary.org/obo/PR_000001024	neural cell adhesion molecule 1	http://purl.obolibrary.org/obo/PR_000001023	neural cell adhesion molecule NCAM		A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001083	CD2 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001084	T-cell surface glycoprotein CD8 alpha chain	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.
http://purl.obolibrary.org/obo/PR_000001085	T-cell surface glycoprotein CD8 beta chain	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.
http://purl.obolibrary.org/obo/PR_000001087	adhesion G-protein coupled receptor	http://purl.obolibrary.org/obo/PR_000030035	G-protein coupled receptor		A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs.
http://purl.obolibrary.org/obo/PR_000001094	rhodopsin-like G-protein coupled receptor	http://purl.obolibrary.org/obo/PR_000030035	G-protein coupled receptor		A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions.
http://purl.obolibrary.org/obo/PR_000001128	chemokine receptor	http://purl.obolibrary.org/obo/PR_000001094	rhodopsin-like G-protein coupled receptor		A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines.
http://purl.obolibrary.org/obo/PR_000001197	chemokine receptor CCR1/3/1L	http://purl.obolibrary.org/obo/PR_000001128	chemokine receptor		A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001199	C-C chemokine receptor type 2	http://purl.obolibrary.org/obo/PR_000001128	chemokine receptor		A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13.
http://purl.obolibrary.org/obo/PR_000001203	C-C chemokine receptor type 7	http://purl.obolibrary.org/obo/PR_000001128	chemokine receptor		A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21.
http://purl.obolibrary.org/obo/PR_000001254	C-C chemokine receptor type 1	http://purl.obolibrary.org/obo/PR_000001197	chemokine receptor CCR1/3/1L		A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001255	C-C chemokine receptor type 3	http://purl.obolibrary.org/obo/PR_000001197	chemokine receptor CCR1/3/1L		A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001281	ADP-ribosyl cyclase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that contains the ADP-ribosyl cyclase domain (Pfam:PF02267).
http://purl.obolibrary.org/obo/PR_000001289	membrane-spanning 4-domains subfamily A member 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001293	C-type lectin domain family 4 member K	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001307	CD44 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001308	CD48 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001313	E/P-selectin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core domain structure consisting of one lectin C-type domain (Pfam:PF00059), followed by one EGF domain (Pfam:PF00008), followed by 4-9 sushi domains (Pfam:PF00084), with the P-selectins generally being longer.
http://purl.obolibrary.org/obo/PR_000001318	L-selectin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes.
http://purl.obolibrary.org/obo/PR_000001322	angiotensin-converting enzyme	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ACE gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001327	cadherin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues.
http://purl.obolibrary.org/obo/PR_000001332	cell adhesion molecule CEACAM8	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001338	complement receptor type 2	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001343	CD69 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
http://purl.obolibrary.org/obo/PR_000001344	ectonucleotide pyrophosphatase/phosphodiesterase family member 3	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001345	endoglin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001352	glycophorin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that contains an extracellular Glycophorin A domain (Pfam:PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane.
http://purl.obolibrary.org/obo/PR_000001355	immunoglobulin gamma Fc receptor II/III/IV	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III.
http://purl.obolibrary.org/obo/PR_000001380	interleukin-2 receptor subunit alpha	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001381	interleukin-2 receptor subunit beta	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001401	membrane cofactor protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD46 gene or a 1:1 ortholog thereof. This protein act as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue.
http://purl.obolibrary.org/obo/PR_000001403	tetraspanin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least four cysteine residues, including a highly conserved 'CCG' motif.
http://purl.obolibrary.org/obo/PR_000001408	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	http://purl.obolibrary.org/obo/PR_000001281	ADP-ribosyl cyclase		An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001415	E-selectin	http://purl.obolibrary.org/obo/PR_000001313	E/P-selectin		An E/P-selectin that is a translation product of the human SELE gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001444	cadherin-5	http://purl.obolibrary.org/obo/PR_000001327	cadherin		A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001460	glycophorin-A	http://purl.obolibrary.org/obo/PR_000001352	glycophorin		A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain.
http://purl.obolibrary.org/obo/PR_000001479	low affinity immunoglobulin gamma Fc region receptor II	http://purl.obolibrary.org/obo/PR_000001355	immunoglobulin gamma Fc receptor II/III/IV		An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001481	low affinity immunoglobulin gamma Fc region receptor II-b	http://purl.obolibrary.org/obo/PR_000001355	immunoglobulin gamma Fc receptor II/III/IV		An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001483	low affinity immunoglobulin gamma Fc region receptor III	http://purl.obolibrary.org/obo/PR_000001355	immunoglobulin gamma Fc receptor II/III/IV		An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001785	prominin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of one Prominin (Pfam:PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and human prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain.
http://purl.obolibrary.org/obo/PR_000001786	prominin-1	http://purl.obolibrary.org/obo/PR_000001785	prominin		A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001808	C/C-C motif small inducible chemokine	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain.
http://purl.obolibrary.org/obo/PR_000001809	CD59-like glycoprotein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof.
http://purl.obolibrary.org/obo/PR_000001810	CSF-1/PDGF receptor-type tyrosine-protein kinase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines.
http://purl.obolibrary.org/obo/PR_000001813	adhesion G protein-coupled receptor E1	http://purl.obolibrary.org/obo/PR_000001087	adhesion G-protein coupled receptor		An adhesion G-protein coupled receptor that is a translation product of the human ADGRE1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001832	SIRP/SHPS-1 family protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (Pfam:PF07686), two Immunoglobulin C1-set domains (Pfam:PF07654), a single-pass transmembrane region and a very small cytoplasmic region.
http://purl.obolibrary.org/obo/PR_000001833	SLAM family member 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001836	CD7 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001839	T-cell surface glycoprotein CD5	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001843	Thy-1 membrane glycoprotein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001861	integrin beta	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (Pfam:PF00362), up to four EGF-like domains (Pfam:PF07974), and an Integrin beta tail domain (Pfam:PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (Pfam:PF08725).
http://purl.obolibrary.org/obo/PR_000001865	interleukin-3 receptor class 2 alpha chain	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001867	interleukin-5 receptor subunit alpha	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001869	interleukin-7 receptor subunit alpha	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001874	KLRB1-like protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat.
http://purl.obolibrary.org/obo/PR_000001879	leukosialin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001880	low affinity immunoglobulin epsilon Fc receptor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001883	lysosome-associated membrane protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (Pfam:PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane.
http://purl.obolibrary.org/obo/PR_000001889	CD14 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001892	CD33 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001896	natural killer cell receptor 2B4	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001898	neprilysin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001903	paired box protein PAX-5	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001919	programmed cell death protein 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001925	scavenger receptor cysteine-rich type 1 protein M130	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001932	signal transducer CD24	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001935	syndecan-1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001938	thrombomodulin-like receptor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (Pfam:PF00059), 5 or 6 EGF-like domains (Pfam:PF00008, Pfam:PF09064, or Pfam:PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids).
http://purl.obolibrary.org/obo/PR_000001944	transcription factor PU.1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001945	transferrin receptor protein 1	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001950	tumor necrosis factor ligand superfamily member 5	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001963	CD27 molecule	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001968	tyrosine-protein phosphatase non-receptor type substrate 1	http://purl.obolibrary.org/obo/PR_000001832	SIRP/SHPS-1 family protein		A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001969	urokinase plasminogen activator surface receptor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000001971	vascular endothelial growth factor receptor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain.
http://purl.obolibrary.org/obo/PR_000001990	C-C motif chemokine 18	http://purl.obolibrary.org/obo/PR_000001808	C/C-C motif small inducible chemokine		A C/C-C motif small inducible chemokine that is a translation product of the human CCL18 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002001	receptor-type tyrosine-protein kinase FLT3	http://purl.obolibrary.org/obo/PR_000001810	CSF-1/PDGF receptor-type tyrosine-protein kinase		A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002037	complement component C1q receptor	http://purl.obolibrary.org/obo/PR_000001938	thrombomodulin-like receptor		A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002062	macrophage colony-stimulating factor 1 receptor	http://purl.obolibrary.org/obo/PR_000001810	CSF-1/PDGF receptor-type tyrosine-protein kinase		A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002064	macrosialin	http://purl.obolibrary.org/obo/PR_000001883	lysosome-associated membrane protein		A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002065	mast/stem cell growth factor receptor	http://purl.obolibrary.org/obo/PR_000001810	CSF-1/PDGF receptor-type tyrosine-protein kinase		A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002112	vascular endothelial growth factor receptor 2	http://purl.obolibrary.org/obo/PR_000001971	vascular endothelial growth factor receptor		A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002976	Ly-6-like protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is the translation product of any of the LY6 genes (LY6A-LY6I).
http://purl.obolibrary.org/obo/PR_000002977	killer cell lectin-like receptor subfamily B member 1C	http://purl.obolibrary.org/obo/PR_000001874	KLRB1-like protein		A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002978	lymphocyte antigen 6G	http://purl.obolibrary.org/obo/PR_000002976	Ly-6-like protein		An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002979	lymphocyte antigen 6A-2/6E-1	http://purl.obolibrary.org/obo/PR_000002976	Ly-6-like protein		An Ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002980	lymphocyte antigen 6C2	http://purl.obolibrary.org/obo/PR_000002976	Ly-6-like protein		An Ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000002981	lymphocyte antigen 76 (mouse)	http://purl.obolibrary.org/obo/PR_000029032	Mus musculus protein		A protein that is a translation product of the Ly76 gene in mouse.
http://purl.obolibrary.org/obo/PR_000003015	prostate-specific antigen	http://purl.obolibrary.org/obo/PR_000027795	trypsin		A trypsin that is a translation product of the human KLK3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003262	collagen alpha chain	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a component of collagen. Collagens are trimeric molecules in which each chain comprises a repeating Gly-X-Y triplet, in which X and Y can be any residue but are usually proline and hydroxyproline, respectively. This results in a left-handed helix that combines with other two to form a triple-helical structure.
http://purl.obolibrary.org/obo/PR_000003263	collagen type I alpha chain	http://purl.obolibrary.org/obo/PR_000003262	collagen alpha chain		A collagen alpha chain that is a translation product of the human COL1A1 or COL1A2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003264	collagen alpha-1(I) chain	http://purl.obolibrary.org/obo/PR_000003263	collagen type I alpha chain		A collagen type I alpha chain that is a translation product of the human COL1A1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003328	collagen alpha-1(III) chain	http://purl.obolibrary.org/obo/PR_000003262	collagen alpha chain		A collagen alpha chain that is a translation product of the human COL3A1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003353	collagen alpha-1(VI) chain	http://purl.obolibrary.org/obo/PR_000003386	collagen type VI alpha chain		A collagen type VI alpha chain that is a translation product of the human COL6A1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000003386	collagen type VI alpha chain	http://purl.obolibrary.org/obo/PR_000003262	collagen alpha chain		A collagen alpha chain that is a translation product of the human COL6A1, COL6A2, or COL6A3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is produced as the result of proteolytic processing of a longer protein.
http://purl.obolibrary.org/obo/PR_000018780	prostate-specific antigen proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A prostate-specific antigen that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000018798	collagen alpha-1(I) chain proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A collagen alpha-1(I) chain that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000025796	integrin alpha	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif.
http://purl.obolibrary.org/obo/PR_000025875	serpin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is primarily known as an irreversible serine protease inhibitor active against S1, S8 and C14 peptidases. There are both extra- and intra-cellular serpins, which are found in all groups of organisms with the notable exception of fungi. Serpin contains a copy of the Serpin (Pfam:PF00079) domain.
http://purl.obolibrary.org/obo/PR_000030035	G-protein coupled receptor	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.
http://purl.obolibrary.org/obo/PR_000036194	eukaryotic protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is encoded in the genome of some Eukaryota.
http://purl.obolibrary.org/obo/PR_000037069	glycoprotein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that includes at least one glycosylated residue.
http://purl.obolibrary.org/obo/PR_000021115	vitamin K-dependent protein Z proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000013275	vitamin K-dependent protein Z		A vitamin K-dependent protein Z that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000021126	serine protease 1 proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000013318	serine protease 1		A serine protease 1 that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000021170	parathyroid hormone proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000013429	parathyroid hormone		A parathyroid hormone that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000021416	alpha-1-antitrypsin proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000014678	alpha-1-antitrypsin		An alpha-1-antitrypsin that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000021468	sonic hedgehog protein proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A sonic hedgehog protein that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000021841	von Willebrand factor proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A von Willebrand factor that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000023341	beta-hexosaminidase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the Escherichia coli K-12 nagZ gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000023661	orotidine 5'-phosphate decarboxylase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the Escherichia coli K-12 pyrF gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000025403	T-cell surface glycoprotein CD8 alpha chain isoform 1	http://purl.obolibrary.org/obo/PR_000001084	T-cell surface glycoprotein CD8 alpha chain		A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound.
http://purl.obolibrary.org/obo/PR_000025405	T-cell surface glycoprotein CD8 beta chain isoform 1	http://purl.obolibrary.org/obo/PR_000001085	T-cell surface glycoprotein CD8 beta chain		A T-cell surface glycoprotein CD8 beta chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10966-1 or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000025406	T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form	http://purl.obolibrary.org/obo/PR_000025403	T-cell surface glycoprotein CD8 alpha chain isoform 1		A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form.
http://purl.obolibrary.org/obo/PR_000025407	T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form	http://purl.obolibrary.org/obo/PR_000025405	T-cell surface glycoprotein CD8 beta chain isoform 1		A T-cell surface glycoprotein CD8 beta chain isoform 1 that has had the signal peptide removed to yield the mature form.
http://purl.obolibrary.org/obo/PR_000025408	T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed glycosylated form	http://purl.obolibrary.org/obo/PR_000025406	T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form		A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue.
http://purl.obolibrary.org/obo/PR_000025409	T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed glycosylated form	http://purl.obolibrary.org/obo/PR_000025407	T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form		A T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form that includes at least one glycosylated residue.
http://purl.obolibrary.org/obo/PR_000025416	cartilage oligomeric matrix protein proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A cartilage oligomeric matrix protein that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000025420	collagen alpha-1(VI) chain proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A collagen alpha-1(VI) chain that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000025455	CD2 molecule proteolytic cleavage product	http://purl.obolibrary.org/obo/PR_000018264	proteolytic cleavage product		A CD2 molecule that has been processed by proteolytic cleavage.
http://purl.obolibrary.org/obo/PR_000027222	CALCA gene translation product	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human CALCA gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000029032	Mus musculus protein	http://purl.obolibrary.org/obo/PR_000036194	eukaryotic protein		A protein that is encoded in the genome of Mus musculus.
http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein	http://purl.obolibrary.org/obo/PR_000036194	eukaryotic protein		A protein that is encoded in the genome of Homo sapiens.
http://purl.obolibrary.org/obo/PR_P02649	apolipoprotein E (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An apolipoprotein E that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02655	apolipoprotein C-II (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An apolipoprotein C-II that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02656	apolipoprotein C-III (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An apolipoprotein C-III that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P02768	albumin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An albumin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P04278	sex hormone-binding globulin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A sex hormone-binding globulin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P06727	apolipoprotein A-IV (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An apolipoprotein A-IV that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P12277	creatine kinase B-type (human)	http://purl.obolibrary.org/obo/PR_000050097	creatine kinase (human)		A creatine kinase B-type that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P12821	angiotensin-converting enzyme (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An angiotensin-converting enzyme that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P15529	membrane cofactor protein (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A membrane cofactor protein that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P17931	galectin-3 (human)	http://purl.obolibrary.org/obo/PR_000009771	galectin-3		A galectin-3 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P27918	properdin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A properdin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P28799	progranulin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A progranulin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_Q15848	adiponectin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		An adiponectin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_O14841	5-oxoprolinase (human)	http://purl.obolibrary.org/obo/PR_000011649	5-oxoprolinase		A 5-oxoprolinase that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P55774	C-C motif chemokine 18 (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A C-C motif chemokine 18 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_Q12882	dihydropyrimidine dehydrogenase [NADP(+)] (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_Q9UBS3	DnaJ homolog subfamily B member 9 (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A DnaJ homolog subfamily B member 9 that is encoded in the genome of human.
http://purl.obolibrary.org/obo/CL_0008024	pancreatic endocrine cell	http://purl.obolibrary.org/obo/CL_0000164	enteroendocrine cell		An endocrine cell that is part of the pancreas.
http://purl.obolibrary.org/obo/CL_0011115	precursor cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that, by division or terminal differentiation, can give rise to other cell types.
http://purl.obolibrary.org/obo/NBO_0000073	chewing	http://purl.obolibrary.org/obo/NBO_0000747	jaw movement		The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC]
http://purl.obolibrary.org/obo/HP_0025337	Red eye	http://purl.obolibrary.org/obo/HP_0008047	Abnormality of the vasculature of the eye		A reddish appearance over the white part (sclera) of the eye ranging from a few enlarged blood vessels appearing as wiggly lines over the sclera to a bright red color completely covering to sclera.
http://purl.obolibrary.org/obo/HP_0025318	Ovarian carcinoma	http://purl.obolibrary.org/obo/HP_0100615	Ovarian neoplasm		A malignant neoplasm originating from the surface ovarian epithelium.
http://purl.obolibrary.org/obo/HP_0025320	Leakage of dye on fundus fluorescein angiography	http://purl.obolibrary.org/obo/HP_0030604	Abnormal fundus fluorescein angiography		Leakage of fluorescein dye observed upon retinal fluorescein angiography. Areas of leakage can be appreciated as showing gradual enlargement with blurring of margins.
http://purl.obolibrary.org/obo/HP_0025321	Copper accumulation in liver	http://purl.obolibrary.org/obo/HP_0034644	Abnormal liver metabolite concentration		An anomalous build up of copper (Cu) in the liver.
http://purl.obolibrary.org/obo/HP_0025322	Venous occlusion	http://purl.obolibrary.org/obo/HP_0030846	Abnormality of venous physiology		Blockage of venous return (flow of blood from the periphery back towards the right atrium) in a vein.
http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology	http://purl.obolibrary.org/obo/HP_0030163	Abnormal vascular physiology		An anomaly of arterial function.
http://purl.obolibrary.org/obo/HP_0025324	Arterial occlusion	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Blockage of blood flow through an artery.
http://purl.obolibrary.org/obo/HP_0025325	Sparse medial eyebrow	http://purl.obolibrary.org/obo/HP_0045075	Sparse eyebrow		Decreased density/number and/or decreased diameter of medial eyebrow hairs.
http://purl.obolibrary.org/obo/HP_0025326	Retinal arterial occlusion	http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology		Blockage of the retinal artery, generally associated with interruption of blood flow and oxygen delivery to the retina.
http://purl.obolibrary.org/obo/HP_0025327	Decreased renal parenchymal thickness	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Reduced dimension of the solid part of the kidney (parenchyma, the renal cortex and medulla) as measured from the collecting system (renal calyces and pelvis) to the border of the kidney. This measurement can be performed by measuring the thickness of the parenchyma in computed tomography scans.
http://purl.obolibrary.org/obo/HP_0025328	Antepartum hemorrhage	http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage		Significant maternal hemorrhage/bleed in the second half of pregnancy and prior to the birth of the baby.
http://purl.obolibrary.org/obo/HP_0025329	Anti-glutamic acid decarboxylase antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against glutamic acid decarboxylase.
http://purl.obolibrary.org/obo/HP_0025330	Downgaze palsy	http://purl.obolibrary.org/obo/HP_0000511	Vertical supranuclear gaze palsy		A limitation of the ability to direct one's gaze below the horizontal meridian.
http://purl.obolibrary.org/obo/HP_0025331	Upgaze palsy	http://purl.obolibrary.org/obo/HP_0000511	Vertical supranuclear gaze palsy		A limitation of the ability to direct one's gaze above the horizontal meridian.
http://purl.obolibrary.org/obo/HP_0025332	Abnormality of foot cortical bone	http://purl.obolibrary.org/obo/HP_0003103	Abnormal cortical bone morphology		An anomaly of the outer shell (cortex) of a foot bone.
http://purl.obolibrary.org/obo/HP_0025333	Cortical thinning of foot bones	http://purl.obolibrary.org/obo/HP_0025332	Abnormality of foot cortical bone		A reduction in the thickness of the outer shell (cortex) of foot bones.
http://purl.obolibrary.org/obo/HP_0025334	Triggered by emotion	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by a strong spontaneously arising mental state, reaction or feeling (emotion).
http://purl.obolibrary.org/obo/HP_0025335	Delayed ability to stand	http://purl.obolibrary.org/obo/HP_0002194	Delayed gross motor development		A failure to achieve the ability to stand up at an appropriate developmental stage. Most children begin to walk alone at 11 to 15 months of age. On average, children can stand while holding on at the age of 9 to 10 months, can pull up to stand and walk with one hand being held at 12 months, and can stand alone and walk well at 18 months.
http://purl.obolibrary.org/obo/HP_0025336	Delayed ability to sit	http://purl.obolibrary.org/obo/HP_0002194	Delayed gross motor development		A failure to achieve the ability to sit at an appropriate developmental stage. Most children sit with support at 6 months of age and sit steadily without support at 9 months of age.
http://purl.obolibrary.org/obo/HP_0025338	Circumlimbal hyperemia	http://purl.obolibrary.org/obo/HP_0030953	Conjunctival hyperemia		A ring of redness at the limbus of the eye, the border between the cornea and the sclera.
http://purl.obolibrary.org/obo/HP_0025339	Superficial episcleral hyperemia	http://purl.obolibrary.org/obo/HP_0025337	Red eye		Prominence of blood vessels of the superficial episcleral tissues.
http://purl.obolibrary.org/obo/HP_0025340	Deep episcleral hyperemia	http://purl.obolibrary.org/obo/HP_0025337	Red eye		Prominence of blood vessels of the deep episcleral tissues.
http://purl.obolibrary.org/obo/HP_0025341	Corneal keratic precipitates	http://purl.obolibrary.org/obo/HP_0011488	Abnormal corneal endothelium morphology		An inflammatory cellular deposit deposited on the corneal endothelium and visible as spots on the cornea.
http://purl.obolibrary.org/obo/HP_0025342	Central retinal artery occlusion	http://purl.obolibrary.org/obo/HP_3000032	Abnormality of central retinal artery		Blockage of the main artery in the retina. In the acute phase, the fundus may show cherry red spot and stasis of retinal flow. The typical presentation is one of profound monocular visual loss.
http://purl.obolibrary.org/obo/HP_0025343	Lupus anticoagulant	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		Presence of lupus anticoagulant (LA) autoantibodies. LA represent a heterogeneous group of autoantibodies, IgG, IgM, or a mixture of both classes, that interfere with standard phospholipid-based coagulant tests (this is only an in vitro phenomenon, LA do not cause reduction of coagulation in vivo). The antibodies are directed against plasma proteins which also bind to phospholipid surfaces.
http://purl.obolibrary.org/obo/HP_0025344	Interlobular bile duct destruction	http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology		Damage to and obliteration of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts).
http://purl.obolibrary.org/obo/HP_0025345	Abnormal circulating beta-2-microglobulin concentration	http://purl.obolibrary.org/obo/HP_0025465	Abnormal circulating beta globulin concentration		Any deviation from the normal concentration of beta-2-microglobulin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025346	Elevated circulating beta-2-microglobulin concentration	http://purl.obolibrary.org/obo/HP_0025345	Abnormal circulating beta-2-microglobulin concentration		The concentration of beta-2-microglobulin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025347	Decreased circulating beta-2-microglobulin concentration	http://purl.obolibrary.org/obo/HP_0025345	Abnormal circulating beta-2-microglobulin concentration		The concentration of beta-2-microglobulin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025348	Abnormal corneal limbus morphology	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		An anomaly of the margin of the cornea overlapped by the sclera.
http://purl.obolibrary.org/obo/HP_0025349	Limbal edema	http://purl.obolibrary.org/obo/HP_0025348	Abnormal corneal limbus morphology		Swelling of the margin of the cornea overlapped by the sclera.
http://purl.obolibrary.org/obo/HP_0025350	Giant conjunctival papillae	http://purl.obolibrary.org/obo/HP_0030946	Conjunctival papillae		Conjunctival papillae with a diameter greater than 1 millimeter. They characteristically have flattened tops which sometimes demonstrate staining with fluorescein.
http://purl.obolibrary.org/obo/HP_0025351	Recurrent interdigital mycosis	http://purl.obolibrary.org/obo/HP_0002841	Recurrent fungal infections		A history of repeated fungal infections located between the fingers or toes, usually manifested by scaling, maceration, and itching. The toes are more commonly affected than the fingers.
http://purl.obolibrary.org/obo/HP_0025352	Typically de novo	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Description of conditions that are exclusively or predominantly observed to display de novo variants. In some cases, this may be due to the limited reproductive fitness of affected individuals.
http://purl.obolibrary.org/obo/HP_0025353	Anti-multiple nuclear dots antibody positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		A type of antinuclear antibody (ANA) positivity revealed by indirect immunofluorescence (IFL). The multiple nuclear dots (MND) pattern is immunomorphologically characterized by the staining of 3-20 dots of variable size distributed all over the cell nucleus, but sparing the nucleoli, and, in contrast to the anticentromere pattern, MND reactivity does not stain the chromosomes in mitotic cells.
http://purl.obolibrary.org/obo/HP_0025354	Abnormal cellular phenotype	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An anomaly of cellular morphology or physiology.
http://purl.obolibrary.org/obo/HP_0025355	Retinal arteriolar macroaneurysms	http://purl.obolibrary.org/obo/HP_0000630	Abnormal retinal arterial/arteriolar morphology		Acquired focal dilatations of branches of the retinal artery, usually second-order retinal arterioles, that range in size from 100 to 200 micrometers in diameter. Macroaneurysms are generally located at the temporal retina and may be hemorrhagic or exudative.
http://purl.obolibrary.org/obo/HP_0025357	Erratic myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		A type of myoclonus in which the myoclonias shift from body region to another in a random and asynchronous fashion. Erratic myoclonus can affect the face or limbs, are brief, single or repetitive, very frequent and nearly continuous.
http://purl.obolibrary.org/obo/HP_0025358	Uveal ectropion	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		Presence of iris pigment epithelium on the anterior surface of the iris.
http://purl.obolibrary.org/obo/HP_0025359	Polygonal renal calices	http://purl.obolibrary.org/obo/HP_0011130	Abnormal renal calyx morphology		An abnormal polygonal shape of the calices of the kidney (which normally have a rounded or cup-shaped appearance).
http://purl.obolibrary.org/obo/HP_0025360	Polycalycosis	http://purl.obolibrary.org/obo/HP_0011130	Abnormal renal calyx morphology		Increased number of calices of the kidney.
http://purl.obolibrary.org/obo/HP_0025361	Abnormal medullary pyramid morphology	http://purl.obolibrary.org/obo/HP_0100957	Abnormal renal medulla morphology		A structural anomaly of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla.
http://purl.obolibrary.org/obo/HP_0025362	Renal medullary pyramid hypoplasia	http://purl.obolibrary.org/obo/HP_0025361	Abnormal medullary pyramid morphology		Undergrowth of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla.
http://purl.obolibrary.org/obo/HP_0025363	Glomerular endocapillary hypercellularity	http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology		Hypercellularity due to increased number of cells within glomerular capillary lumina, causing narrowing of the lumina.
http://purl.obolibrary.org/obo/HP_0025364	Glomerular extracapillary hypercellularity	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Hypercellularity (increased number of cells) in the renal glomerulus but external to the glomerular capillaries, i.e., in the Bowman space or more than one layer of parietal or visceral epithelial cells.
http://purl.obolibrary.org/obo/HP_0025367	Trichoepithelioma	http://purl.obolibrary.org/obo/HP_0012843	Hair follicle neoplasm		A benign hair follicle tumor whose tumor cells form rudimentary hair follicles but not actual hair shafts. A trichoepithelioma is usually less than one centimeter, firm, round, and shihy with yellow, pink, brown, or bluish color. They may occur multiply, usually on the face, and may gradually increase in number with age.
http://purl.obolibrary.org/obo/HP_0025368	Abnormal growth plate morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		A structural anomaly of the growth plates (epiphyseal plates), areas of cartilage located near the ends of long bones that are located between the metaphysis (widened part of the shaft of the bone) and the epiphysis (end of the bone) and in which growth occurs in the developing bone. After conclusion of bone growth, the growth plates ossify (harden into solid bone).
http://purl.obolibrary.org/obo/HP_0025369	Thick growth plates	http://purl.obolibrary.org/obo/HP_0025368	Abnormal growth plate morphology		Increased thickness (dimension along the axis of the bone) of the growth plate.
http://purl.obolibrary.org/obo/HP_0025370	Abnormal ossification of the sacrum	http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology		Abnormal bone tissue formation (ossification) affecting the sacrum.
http://purl.obolibrary.org/obo/HP_0025371	Delayed ossification of the sacrum	http://purl.obolibrary.org/obo/HP_0025370	Abnormal ossification of the sacrum		Formation of the sacrum bone tissue occurs later than age-adjusted norms.
http://purl.obolibrary.org/obo/HP_0045081	Abnormality of body mass index	http://purl.obolibrary.org/obo/HP_0004323	Abnormality of body weight		Anomaly in the weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of obesity and underweight compared to averages.
http://purl.obolibrary.org/obo/HP_0045082	Decreased body mass index	http://purl.obolibrary.org/obo/HP_0045081	Abnormality of body mass index		Abnormally decreased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of underweight compared to averages.
http://purl.obolibrary.org/obo/GO_0140029	exocytic process	http://purl.obolibrary.org/obo/GO_0009987	cellular process		The cellular processes that contribute to exocytosis.
http://purl.obolibrary.org/obo/GO_0140039	cell-cell adhesion in response to extracellular stimulus	http://purl.obolibrary.org/obo/GO_0098609	cell-cell adhesion		The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.
http://purl.obolibrary.org/obo/CHEBI_138130	Delta(7)-sterol	http://purl.obolibrary.org/obo/CHEBI_15889	sterol		Any sterol that contains a double bond between positions 7 and 8.
http://purl.obolibrary.org/obo/CHEBI_138141	17alpha-hydroxy-C21-steroid	http://purl.obolibrary.org/obo/CHEBI_61313	C21-steroid		Any C<small><sub>21</sub></small>-steroid carrying a hydroxy substituent at the 17α-position. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure.
http://purl.obolibrary.org/obo/GO_0099170	postsynaptic modulation of chemical synaptic transmission	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.
http://purl.obolibrary.org/obo/GO_0099171	presynaptic modulation of chemical synaptic transmission	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
http://purl.obolibrary.org/obo/HP_0031263	Abnormal renal corpuscle morphology	http://purl.obolibrary.org/obo/HP_0012575	Abnormal nephron morphology		Any anomalous structure of the renal corpuscle, which is the initial component of the nephron that filters blood. The renal corpuscle consists of a knot of capillaries (glomerulus) that is surrounded by a double-walled capsule (Bowman capsule) that opens into a renal tubule.
http://purl.obolibrary.org/obo/HP_0031284	Flushing	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		Recurrent episodes of redness of the skin together with a sensation of warmth or burning of the affected areas of skin.
http://purl.obolibrary.org/obo/HP_0031306	Intracranial arterial calcification	http://purl.obolibrary.org/obo/HP_0003207	Arterial calcification		An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in an artery that is located within the skull (intracranial).
http://purl.obolibrary.org/obo/HP_0031365	Macular purpura	http://purl.obolibrary.org/obo/HP_0000979	Purpura		Purpura that is flat (non-palpable, not raised).
http://purl.obolibrary.org/obo/HP_0031383	Abnormal lymphocyte surface marker expression	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		Abnormal amount of a protein that is normally present on the cell surface of lymphocytes.
http://purl.obolibrary.org/obo/HP_0031399	Abnormal double-negative T cell proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Abnormal increase or decrease of double-negative (DN) CD3+CD4-CD8- T cells, measured either as percentage of total CD3+ T cells in the blood, or as absolute number per microliter of blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0031466	Impairment in personality functioning	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		A maladaptive personality trait characterized by moderate or greater impairment in personality (self /interpersonal) functioning.
http://purl.obolibrary.org/obo/HP_0031481	Abnormal mitral valve physiology	http://purl.obolibrary.org/obo/HP_0031650	Abnormal atrioventricular valve physiology		Any functional anomaly of the mitral valve.
http://purl.obolibrary.org/obo/HP_0031547	Abnormal QT interval	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		Any anomaly of the time interval between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).
http://purl.obolibrary.org/obo/HP_0031567	Abnormal aortic valve cusp morphology	http://purl.obolibrary.org/obo/HP_0001646	Abnormal aortic valve morphology		Any structural anomaly of the aortic valve leaflets.
http://purl.obolibrary.org/obo/CHEBI_140325	secondary carboxamide	http://purl.obolibrary.org/obo/CHEBI_37622	carboxamide		A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR<small><sup>1</small></sup>.
http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology	http://purl.obolibrary.org/obo/HP_0000153	Abnormality of the mouth		A functional anomaly of the mouth (which is also known as the oral cavity).
http://purl.obolibrary.org/obo/HP_0031854	Left Isomerism	http://purl.obolibrary.org/obo/HP_0031853	Isomerism		A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal left-sided structures.
http://purl.obolibrary.org/obo/HP_0031855	Right isomerism	http://purl.obolibrary.org/obo/HP_0031853	Isomerism		A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures.
http://purl.obolibrary.org/obo/HP_0031869	Recurrent joint dislocation	http://purl.obolibrary.org/obo/HP_0001373	Joint dislocation		Dislocation of a given joint repeated times.
http://purl.obolibrary.org/obo/PATO_0040019	fibrotic	http://purl.obolibrary.org/obo/PATO_0000025	composition		Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.
http://purl.obolibrary.org/obo/PATO_0050000	rate of occurence	http://purl.obolibrary.org/obo/PATO_0000161	rate		The number of repeated events per unit time, occurring in a repeating series. (e.g. the number of heart beats occurring over 1 minute)
http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure	http://purl.obolibrary.org/obo/GO_0005575	cellular_component		A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
http://purl.obolibrary.org/obo/HP_0032677	Generalized-onset motor seizure	http://purl.obolibrary.org/obo/HP_0020219	Motor seizure		A generalized motor seizure is a type of generalized-onset seizure with predominantly motor (involving musculature) signs. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.
http://purl.obolibrary.org/obo/HP_0032794	Myoclonic seizure	http://purl.obolibrary.org/obo/HP_0020219	Motor seizure		A myoclonic seizure is a type of motor seizure characterized by sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.
http://purl.obolibrary.org/obo/HP_0032894	Seizure precipitated by febrile infection	http://purl.obolibrary.org/obo/HP_0032892	Infection-related seizure		Any form of seizure occurring at the time of a fever (temperature at or above 38.0 degrees Celcius) without infection of the central nervous system, and without an alternative cause such as severe metabolic derangement, occurring at any age.
http://purl.obolibrary.org/obo/HP_0025644	Fixation-off epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011182	Interictal epileptiform activity		Fixation off sensitivity (FOS) is characterized by posterior or generalized epileptiform discharges that consistently occur with conditions that eliminate central vision, such as closed eyes, complete darkness, modified Ganzfeld stimulation (using a large white surface without visual cues), and Frenzel lenses. The FOS electroencephalogram (EEG) pattern usually consists of spikes/polyspikes and waves localized in occipital regions (bilateral or unilateral) or generalized discharges. It is usually inhibited by fixation of gaze, observing patterns, or intermittent photic stimulation (e.g., flashing light or patterns used as stimuli during the recording of the EEG).
http://purl.obolibrary.org/obo/HP_0025646	Bilateral polymicrogyria	http://purl.obolibrary.org/obo/HP_0002126	Polymicrogyria		Polymicrogyria that affects all or some of both cerebral hemispheres.
http://purl.obolibrary.org/obo/HP_0025648	Steroid-sensitive nephrotic syndrome with infrequent relapses	http://purl.obolibrary.org/obo/HP_0025647	Steroid-sensitive nephrotic syndrome		A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of one relapse (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response, or one to three relapses in any 12-month period.
http://purl.obolibrary.org/obo/HP_0025649	Steroid-sensitive nephrotic syndrome with frequent relapses	http://purl.obolibrary.org/obo/HP_0025647	Steroid-sensitive nephrotic syndrome		A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of two or more relapses (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response or four or more relapses in any 12-month period.
http://purl.obolibrary.org/obo/HP_0025650	Steroid-dependent nephrotic syndrome	http://purl.obolibrary.org/obo/HP_0000100	Nephrotic syndrome		A type of nephrotic syndrome in which two consecutive relapses (albumin urine dipstick at least 3+ or proteinuria greater than 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) occur during corticosteroid therapy, or within 14 days of ceasing therapy.
http://purl.obolibrary.org/obo/HP_0033693	Phantosmia	http://purl.obolibrary.org/obo/HP_0004408	Abnormality of the sense of smell		Perception of an odor in the absence of any stimuli in the surrounding environment that could emit the odor.
http://purl.obolibrary.org/obo/HP_0033711	Pulmonary interstitial thickening	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		Pathological thickening of the pulmonary interstitium visualized radiographically and divided into interlobular and intralobular septal thickening.
http://purl.obolibrary.org/obo/HP_0033716	EEG with frontal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform EEG discharges recorded in the frontal region.
http://purl.obolibrary.org/obo/HP_0033717	EEG with temporal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform EEG discharges recorded in the temporal region.
http://purl.obolibrary.org/obo/HP_0033718	EEG with central epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform EEG discharges recorded in the central region.
http://purl.obolibrary.org/obo/HP_0033719	EEG with parietal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform EEG discharges recorded in the parietal region.
http://purl.obolibrary.org/obo/HP_0033720	EEG with occipital epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform EEG discharges recorded in the occipital region.
http://purl.obolibrary.org/obo/HP_0033721	EEG with centrotemporal epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011185	EEG with focal epileptiform discharges		Focal epileptiform EEG discharges recorded in the centrotemporal region.
http://purl.obolibrary.org/obo/HP_0033777	Supernumerary cusp	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		Additional cusps of a dental crown.
http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by eating a certain food.
http://purl.obolibrary.org/obo/HP_0033796	Abnormal leukocyte physiology	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		A functional abnormality of a white blood cell.
http://purl.obolibrary.org/obo/HP_0033799	Abnormal circulating sex hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal concentration of a sex hormone in the blood circulation
http://purl.obolibrary.org/obo/HP_0033811	Abnormal circulating androstenedione concentration	http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level		Any deviation from the normal concentration of androstenedione in the blood circulation.
http://purl.obolibrary.org/obo/HP_4000054	Exanthem	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		A widespread rash.
http://purl.obolibrary.org/obo/UBERON_0039222	cystic artery	http://purl.obolibrary.org/obo/UBERON_0015796	liver blood vessel		An artery that supplies oxygenated blood to the cystic duct.
http://purl.obolibrary.org/obo/UBERON_7500062	tibial tuberosity	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		The tibial tuberosity is on the anterior side of a tibia and is where a patella ligament attaches.
http://purl.obolibrary.org/obo/UBERON_8420000	hair of scalp	http://purl.obolibrary.org/obo/UBERON_0016446	hair of head		Hair that grows on the scalp.
http://purl.obolibrary.org/obo/PATO_0070044	anatomical structure quality	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components.
http://purl.obolibrary.org/obo/PATO_0070045	anatomical histological quality	http://purl.obolibrary.org/obo/PATO_0070044	anatomical structure quality		A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes.
http://purl.obolibrary.org/obo/PATO_0070046	neutrophillic	http://purl.obolibrary.org/obo/PATO_0070045	anatomical histological quality		An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain.
http://purl.obolibrary.org/obo/PATO_0070047	polychromatophilic	http://purl.obolibrary.org/obo/PATO_0070045	anatomical histological quality		An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions.
http://purl.obolibrary.org/obo/HP_4000067	Iliac artery aneurysm	http://purl.obolibrary.org/obo/HP_4000066	Abnormal iliac artery morphology		Abnormal outpouching or sac-like dilatation in the iliac artery.
http://purl.obolibrary.org/obo/HP_4000068	Abnormal interest	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		Any deviation from normal intensity or subject of a person's interests, which can be defined as a state of giving selective attention to something.
http://purl.obolibrary.org/obo/HP_4000069	Persistent preoccupation with parts of objects	http://purl.obolibrary.org/obo/HP_5200108	Nonfunctional or atypical use of objects in play		A type of abnormal interest characterized by a persistent and intense focus on parts of a toy/object. For example, affected individuals may spin the wheels on a toy car rather than drive the toy car.
http://purl.obolibrary.org/obo/HP_4000070	Fixated interests	http://purl.obolibrary.org/obo/HP_0031432	Restricted or repetitive behaviors or interests		Highly restricted, fixated interests that are abnormal in intensity or focus (e.g., strong attachment to or preoccupation with unusual objects, excessively circumscribed or perseverative interests).
http://purl.obolibrary.org/obo/CL_0009091	Leydig stem cell	http://purl.obolibrary.org/obo/CL_0000034	stem cell		A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells.
http://purl.obolibrary.org/obo/CL_0009115	lymph node lymphatic vessel endothelial cell	http://purl.obolibrary.org/obo/CL_0002138	endothelial cell of lymphatic vessel		An endothelial cell located in a lymph node lymphatic vessel.
http://purl.obolibrary.org/obo/CL_0009116	progenitor cell of mammary luminal epithelium	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells.
http://purl.obolibrary.org/obo/CHEBI_191220	(2S)-methylsuccinate(2-)	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		The dicarboxylate anion of (<i>S</i>)-methylsuccinic acid; major species at pH 7.3.
http://purl.obolibrary.org/obo/PATO_0040058	absence of physical object	http://purl.obolibrary.org/obo/PATO_0001241	physical object quality		A quality denoting the lack of a physical entity or object, such as a chemical.
http://purl.obolibrary.org/obo/PATO_0040060	absence of anatomical entity	http://purl.obolibrary.org/obo/PATO_0040058	absence of physical object		A quality denoting the lack of an anatomical entity or cellular component.
http://purl.obolibrary.org/obo/PATO_0040072	high nuclear/cytoplasmic ratio	http://purl.obolibrary.org/obo/PATO_0001396	cellular quality		A quality inhering in a cell by virtue of the cell having a high nuclear/cytoplasmic ratio.
http://purl.obolibrary.org/obo/UBERON_7500107	sphenovomerine suture	http://purl.obolibrary.org/obo/UBERON_0009199	facial suture		A suture joining a sphenoid bone with the alae of a vomer to form a schindylesis type of joint.
http://purl.obolibrary.org/obo/UBERON_8480014	skin of buttock	http://purl.obolibrary.org/obo/UBERON_0001415	skin of pelvis		A zone of skin that is part of the buttock.
http://purl.obolibrary.org/obo/UBERON_8480026	skin of iliac crest region	http://purl.obolibrary.org/obo/UBERON_0001415	skin of pelvis		A zone of skin that is above the iliac crest in the pelvic girdle bone/zone.
http://purl.obolibrary.org/obo/UBERON_8480030	skin of breast	http://purl.obolibrary.org/obo/UBERON_0001868	skin of chest		A zone of skin that is part of the breast.
http://purl.obolibrary.org/obo/UBERON_8480037	subserosa of fallopian tube	http://purl.obolibrary.org/obo/UBERON_0012375	subserosa		Subserosa that is part of the uterine tube. It contains loose connective tissue, blood vessels and lymphatic tissue.
http://purl.obolibrary.org/obo/GO_0141060	disruption of anatomical structure in another organism	http://purl.obolibrary.org/obo/GO_0044419	biological process involved in interspecies interaction between organisms		The disruption of an anatomical structure of another organism, leading to damage or temporary subversion of that structure.
http://purl.obolibrary.org/obo/HP_5200104	Abnormal play	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		An abnormality in a child's ability play.
http://purl.obolibrary.org/obo/HP_5200123	Abnormal response to social norms	http://purl.obolibrary.org/obo/HP_0025732	Abnormal social development		An atypical understanding or application of social rules and conventions that guide interpersonal behavior. This may include reduced awareness of social norms or rigid, context-insensitive adherence to them.
http://purl.obolibrary.org/obo/CHEBI_195274	N-acetyl-D-aspartate(2-)	http://purl.obolibrary.org/obo/CHEBI_58496	N-acetyl-D-amino acid anion		An <em>N</em>-acyl-<small>D</small>-α-amino acid anion resulting from deprotonation of both carboxy groups of <em>N</em>-acetyl-<small>D</small>-aspartic acid. Major microspecies at pH 7.3.
http://purl.obolibrary.org/obo/HP_0020224	Mammary duct ectasia	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		A non-proliferative inflammatory disorder of the large duct (milk duct) of the breast; as such, it affects nipple and areola complex. The condition is characterized by focal dilatation of the lactiferous duct system is due to endoluminal changes, as well as the loss of duct wall elastin, leading to abnormally dilated and tortuous lactiferous ducts with associated periductal inflammation and fibrosis. Mammary duct ectasia may present with nipple discharge or palpable mass.
http://purl.obolibrary.org/obo/HP_0020225	Breast abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A circumscribed area of pus or necrotic debris in the breast.
http://purl.obolibrary.org/obo/HP_0020226	Nipple tenderness	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain or discomfort produced by touching the nipple.
http://purl.obolibrary.org/obo/HP_0020227	Floating gallbladder	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		An abnormal configuration in which the gallbladder is pedunculated, hanging free of the liver, and attached only by the cystic mesentery,
http://purl.obolibrary.org/obo/HP_4000201	Abnormal circulating alpha mannosidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Concentration or activity of alpha mannosidase outside of the limits of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_4000209	Abnormal erythrocyte adenosine deaminase activity	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity of adenosine deaminase in red blood cells outside the limits of normal.
http://purl.obolibrary.org/obo/HP_5200214	Somatic hallucination	http://purl.obolibrary.org/obo/HP_0000738	Hallucinations		A type of hallucination that involves the perception of sensory experiences related to the body or its internal organs, systems, or processes. It is a hallucinatory experience that primarily affects bodily sensations rather than external sensory perceptions.
http://purl.obolibrary.org/obo/HP_5200216	Abnormal perceptual state	http://purl.obolibrary.org/obo/HP_5200202	Abnormal interpretation of external stimuli		Temporary alteration of the awareness of reality or self-perception.
http://purl.obolibrary.org/obo/HP_5200261	Abnormal demeanor	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		An anomaly in demeanor, which refers to the outward behavior, manner, or conduct of a person. It encompasses how an individual presents themselves to others in terms of attitude, posture, and general comportment.
http://purl.obolibrary.org/obo/HP_5200263	Abnormally increased volition	http://purl.obolibrary.org/obo/HP_0025780	Abnormal volitional state		An excessive increase in motivated and goal directed as well as non-goal directed behaviors that are usually accompanied by elevated energy and interest that allows individuals to get started, be energized to perform a sustained and directed action. The increase is often disruptive and typically results in unfavorable consequences.
http://purl.obolibrary.org/obo/HP_5200293	Sleep-wake transition abnormality	http://purl.obolibrary.org/obo/HP_0025234	Parasomnia		A parasomnia that occurs with awareness and recollection during the transition between sleep and and awake states.
http://purl.obolibrary.org/obo/HP_5200300	Abnormal movement during sleep	http://purl.obolibrary.org/obo/HP_0025234	Parasomnia		Periodic Limb Movement Disorder, also known as Sleep-Related Myoclonus Syndrome or Nocturnal Myoclonus Syndrome, refers to the periodic and stereotypic movements of the legs or upper limbs during sleep.
http://purl.obolibrary.org/obo/HP_5200329	Problematic alcohol consumption	http://purl.obolibrary.org/obo/HP_0430037	Abnormal alcohol consumption		Impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences.
http://purl.obolibrary.org/obo/HP_5200331	Addictive sedative use	http://purl.obolibrary.org/obo/HP_0033511	Addictive substance use		Misuse and/or abuse of sedative drugs.
http://purl.obolibrary.org/obo/HP_6000162	Excessive licorice consumption	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		Ingestion of large amounts of licorice.
http://purl.obolibrary.org/obo/HP_6000163	Shoulder localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in (or predominant in) the shoulder.
http://purl.obolibrary.org/obo/HP_6000164	Pregnancy conceived despite intrauterine device	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Intrauterine devices (IUDs) are used for contraception. Rarely pregnancy occurs despite the presence of an IUD. Such pregnancies are associated with an increased risk of spontaneous abortion and preterm delivery due to infection, and a higher risk of maternal septic complications.
http://purl.obolibrary.org/obo/HP_6000165	Maternal folate deficiency	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		The mother of a fetus or index patient has a history of folate deficiency during the corresponding pregnancy.
http://purl.obolibrary.org/obo/HP_6000166	Maternal zinc deficiency	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		The mother of a fetus or index patient has a history of abnormally low zinc levels during the corresponding pregnancy.
http://purl.obolibrary.org/obo/HP_6000167	Use of intrauterine device	http://purl.obolibrary.org/obo/HP_0032467	Past obstetric history		Intrauterine devices (IUD) are commonly used for contraception. IUD complications are rare, but include perforation, pelvic infection, expulsion, missing strings, and difficult IUD removal.
http://purl.obolibrary.org/obo/HP_6000168	History of recent central venous catheter	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A past medical history of a recent central venous catheter (CVC). A CVC is an indwelling device inserted into a large, central vein (most commonly the internal jugular, subclavian, or femoral) and advanced until the terminal lumen resides within the inferior vena cava, superior vena cava, or right atrium. CVCs can be a necessary producre for critically ill patients with indications such as total parenteral nutrition administration, dialysis, plasmapheresis, medication administration, and hemodynamic monitoring, and to facilitate further complex interventions such as transvenous pacemaker placement. Complications include arrhythmia, central vein stenosis, and sepsis.
http://purl.obolibrary.org/obo/HP_6000169	History of total parenteral nutrition dependence	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A past medical history of a recent depence on total parenteral nutrition (TPN), which refers to intravenously administered nutrition being the only source of nutrition the patient is receiving.
http://purl.obolibrary.org/obo/HP_6000170	Pain alleviated by testicle elevation	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		This refers to testicular pain that is lessened or made more bearable by elevation of the testicle.
http://purl.obolibrary.org/obo/HP_6000171	Abdominal wall mass	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		An abnormal enlargement or swelling localized to the abdominal wall (the skin, fascia, and muscle encases the abdominal cavity and viscera). The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_0430114	Aplasia/hypoplasia of the uterine cervix	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		Congenital absence or underdevelopment of the uterine cervix.
http://purl.obolibrary.org/obo/HP_6000388	Anti-erythrocyte autoantibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of an antibody in the blood circulation that is directed against an antigen on the surface of erythrocytes (red-blood cells).
http://purl.obolibrary.org/obo/HP_0430143	Elevated circulating C12 acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration		Concentration of C12 acylcarnitines in the blood circulation above the upper limit of normal. C12 acylcarnitines have a twelve-carbon acyl chain.
http://purl.obolibrary.org/obo/HP_0430144	Frontalis muscle overactivity	http://purl.obolibrary.org/obo/HP_3000004	Abnormal frontalis muscle physiology		Increased activity of the frontalis muscle, causing a characteristic staring and astonished facial expression.
http://purl.obolibrary.org/obo/HP_0430145	Nasal dermoid cyst	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		An ectodermal inclusion cyst containing skin and skin appendages; sebaceous glands, hair follicles, and occasionally sweat glands.
http://purl.obolibrary.org/obo/HP_0430146	Elevated circulating complement C3 concentration	http://purl.obolibrary.org/obo/HP_6000474	Elevated circulating complement component concentration		Concentration of the complement component C3 in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0430147	Abnormal circulating inhibin B concentration	http://purl.obolibrary.org/obo/HP_0031099	Abnormal circulating inhibin level		The concentration of inhibin B in the blood circulation is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0430148	Abnormal circulating lipoprotein(a) concentration	http://purl.obolibrary.org/obo/HP_0010980	Hyperlipoproteinemia		The concentration of lipoprotein(a) in the blood circulation is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0430150	Positive blood infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Any kind of test for an infectious agent in the blood circulation positive.
http://purl.obolibrary.org/obo/HP_0430151	Positive respiratory tract infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Any kind of test for an infectious agent in the respiratory tract positive.
http://purl.obolibrary.org/obo/HP_6000474	Elevated circulating complement component concentration	http://purl.obolibrary.org/obo/HP_0005339	Abnormality of complement system		Concentration of a complement component in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000678	Myositis-specific autoantibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that display a high degree of specificity for idiopathic inflammatory myopathy (myositis-specific autoantibodies (MSAs)). MSAs are clinically useful biomarkers to help the diagnosis of polymyositis/dermatomyositis (PM/DM). Many of these are also associated with a unique clinical subset of PM/DM, making them useful in predicting and monitoring certain clinical manifestations.
http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of a lone bone (e.g., the femur, tibia, fibula, humerus, radius, and ulna).
http://purl.obolibrary.org/obo/HP_6000852	Megacolon	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		Persistent and substantial increase in diameter diameter and length of the colon.
http://purl.obolibrary.org/obo/HP_0025794	Reduced MHC I cell surface expression	http://purl.obolibrary.org/obo/HP_6001190	Abnormal MHC surface expression		Expression of major histocompatibility complex class I molecules at the cell surface is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025795	Positive urine infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Any kind of test for an infectious agent in the urine positive (abnormal).
http://purl.obolibrary.org/obo/HP_0025796	Positive urine Legionella pneumophila antigen test	http://purl.obolibrary.org/obo/HP_0025795	Positive urine infectious agent test		Demonstration of an antigen specific to Legionella pneumophila in urine.
http://purl.obolibrary.org/obo/HP_0025797	Unilateral sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		A form of sensorineural hearing impairment that affects one ear.
http://purl.obolibrary.org/obo/HP_0025800	Wrist instability	http://purl.obolibrary.org/obo/HP_0025799	Abnormal wrist physiology		Subjective or objective feeling of clunking/clicking in the wrist with movement, wrist giving way or difficulty twisting objects.
http://purl.obolibrary.org/obo/HP_0025801	Nail elevation	http://purl.obolibrary.org/obo/HP_0009723	Abnormal subungual morphology		Elevation of the nail from the nail bed.
http://purl.obolibrary.org/obo/HP_0025802	Talipes varus	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Inversion of the foot, resulting in the outer side of the sole only touching the ground; usually some degree of talipes equinus is associated with it, and often talipes cavus.
http://purl.obolibrary.org/obo/HP_0025803	Mucocutaneous lesion painful	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Applies to pain that colocalizes with lesions in the skin or mucous membranes.
http://purl.obolibrary.org/obo/HP_0025804	Painful lymphadenopathy	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Applies to pain that is localizes to a swollen lymph node.
http://purl.obolibrary.org/obo/HP_6001190	Abnormal MHC surface expression	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		A deviation from the normal level of major histocompatibility complex (MHC) molecules expressed at the cell surface. The cell-mediated adaptive immune response is regulated by the MHC, which is called human leukocyte antigen (HLA) in humans. HLA molecules are cell surface glycoproteins whose primary function is to present endogenous and exogenous antigens to T lymphocytes for recognition and response. The HLA molecules that present antigen to T lymphocytes are divided into two main classes: HLA class I and HLA class II molecules.
http://purl.obolibrary.org/obo/CL_4072102	Purkinje layer interneuron	http://purl.obolibrary.org/obo/CL_4023057	cerebellar inhibitory GABAergic interneuron		A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex.
http://purl.obolibrary.org/obo/CL_7770004	suprabasal cell	http://purl.obolibrary.org/obo/CL_0000066	epithelial cell		An epithelial cell that resides in the layer(s) immediately above the basal layer in stratified or pseudostratified epithelia. This cell mainly originates from basal cells and is found across various tissues, including skin, esophagus, oral mucosa, airway, and cornea.
http://purl.obolibrary.org/obo/CL_4052065	serous acinar cell of salivary gland	http://purl.obolibrary.org/obo/CL_0020059	serous demilune cell of salivary gland		An acinar cell of the salivary gland, characterized by a pyramidal or triangular shape with a spherical nucleus and abundant eosinophilic zymogen granules. This cell secretes watery, enzyme‐rich fluid containing α-amylase, proline-rich proteins, and secretory immunoglobulins for starch digestion and antimicrobial defence. In humans and mice, serous acinar cell predominates in the parotid gland and to a lesser extent in the submandibular gland, where it exists alongside mucous acinar cells (Maruyama et al., 2019).
http://purl.obolibrary.org/obo/CL_4052066	mucous acinar cell of salivary gland	http://purl.obolibrary.org/obo/CL_0002623	acinar cell of salivary gland		An acinar cell of the salivary gland, responsible for producing a viscous, mucin‐rich solution, thereby facilitating lubrication and protection of the oral mucosa. This cell is characterized by an elongated shape, clear cytoplasm filled with mucin granules, and a basally compressed nucleus (Barrows et al., 2020). In humans and mice, the mucous acinar cell predominates in the sublingual gland and minor salivary glands, while also being present in mixed glands such as the submandibular gland, where it coexists with serous acinar cells (Maruyama et al., 2019).
http://purl.obolibrary.org/obo/GO_0008219	cell death	http://purl.obolibrary.org/obo/GO_0009987	cellular process		Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
http://purl.obolibrary.org/obo/GO_0008277	regulation of G protein-coupled receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0009966	regulation of signal transduction		Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
http://purl.obolibrary.org/obo/GO_0008285	negative regulation of cell population proliferation	http://purl.obolibrary.org/obo/GO_0042127	regulation of cell population proliferation		Any process that stops, prevents or reduces the rate or extent of cell proliferation.
http://purl.obolibrary.org/obo/GO_0008366	axon ensheathment	http://purl.obolibrary.org/obo/GO_0007272	ensheathment of neurons		Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.
http://purl.obolibrary.org/obo/GO_0008482	sulfite oxidase activity	http://purl.obolibrary.org/obo/GO_0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor		Catalysis of the reaction: H2O + O2 + sulfite = H2O2 + H+ + sulfate.
http://purl.obolibrary.org/obo/GO_0008544	epidermis development	http://purl.obolibrary.org/obo/GO_0009888	tissue development		The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
http://purl.obolibrary.org/obo/GO_0009056	catabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
http://purl.obolibrary.org/obo/GO_0009295	nucleoid	http://purl.obolibrary.org/obo/GO_0110165	cellular anatomical structure		The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.
http://purl.obolibrary.org/obo/GO_0009314	response to radiation	http://purl.obolibrary.org/obo/GO_0009628	response to abiotic stimulus		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
http://purl.obolibrary.org/obo/GO_0009438	methylglyoxal metabolic process	http://purl.obolibrary.org/obo/GO_0042180	ketone metabolic process		The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
http://purl.obolibrary.org/obo/GO_0009581	detection of external stimulus	http://purl.obolibrary.org/obo/GO_0051606	detection of stimulus		The series of events in which an external stimulus is received by a cell and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0009582	detection of abiotic stimulus	http://purl.obolibrary.org/obo/GO_0051606	detection of stimulus		The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0009615	response to virus	http://purl.obolibrary.org/obo/GO_0051707	response to other organism		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
http://purl.obolibrary.org/obo/GO_0009636	response to toxic substance	http://purl.obolibrary.org/obo/GO_0042221	response to chemical		Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
http://purl.obolibrary.org/obo/GO_0009790	embryo development	http://purl.obolibrary.org/obo/GO_0007275	multicellular organism development		The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
http://purl.obolibrary.org/obo/GO_0009889	regulation of biosynthetic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
http://purl.obolibrary.org/obo/GO_0009890	negative regulation of biosynthetic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.
http://purl.obolibrary.org/obo/GO_0009891	positive regulation of biosynthetic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
http://purl.obolibrary.org/obo/GO_0009894	regulation of catabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.
http://purl.obolibrary.org/obo/GO_0009895	negative regulation of catabolic process	http://purl.obolibrary.org/obo/GO_0009894	regulation of catabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.
http://purl.obolibrary.org/obo/GO_0009896	positive regulation of catabolic process	http://purl.obolibrary.org/obo/GO_0009894	regulation of catabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.
http://purl.obolibrary.org/obo/GO_0010032	meiotic chromosome condensation	http://purl.obolibrary.org/obo/GO_0030261	chromosome condensation		Compaction of chromatin structure prior to meiosis in eukaryotic cells.
http://purl.obolibrary.org/obo/GO_0010470	regulation of gastrulation	http://purl.obolibrary.org/obo/GO_0045995	regulation of embryonic development		Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.
http://purl.obolibrary.org/obo/GO_0010543	regulation of platelet activation	http://purl.obolibrary.org/obo/GO_0050865	regulation of cell activation		Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
http://purl.obolibrary.org/obo/GO_0010544	negative regulation of platelet activation	http://purl.obolibrary.org/obo/GO_0030195	negative regulation of blood coagulation		Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
http://purl.obolibrary.org/obo/GO_0010559	regulation of glycoprotein biosynthetic process	http://purl.obolibrary.org/obo/GO_1903018	regulation of glycoprotein metabolic process		Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
http://purl.obolibrary.org/obo/GO_0010560	positive regulation of glycoprotein biosynthetic process	http://purl.obolibrary.org/obo/GO_1903020	positive regulation of glycoprotein metabolic process		Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
http://purl.obolibrary.org/obo/GO_0010561	negative regulation of glycoprotein biosynthetic process	http://purl.obolibrary.org/obo/GO_1903019	negative regulation of glycoprotein metabolic process		Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
http://purl.obolibrary.org/obo/GO_0010567	regulation of ketone catabolic process	http://purl.obolibrary.org/obo/GO_0009894	regulation of catabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells.
http://purl.obolibrary.org/obo/GO_0010572	positive regulation of platelet activation	http://purl.obolibrary.org/obo/GO_0010543	regulation of platelet activation		Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
http://purl.obolibrary.org/obo/GO_0010623	programmed cell death involved in cell development	http://purl.obolibrary.org/obo/GO_0048869	cellular developmental process		The activation of endogenous cellular processes that result in the death of a cell as part of its development.
http://purl.obolibrary.org/obo/GO_0010628	positive regulation of gene expression	http://purl.obolibrary.org/obo/GO_0010557	positive regulation of macromolecule biosynthetic process		Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
http://purl.obolibrary.org/obo/GO_0010638	positive regulation of organelle organization	http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization		Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
http://purl.obolibrary.org/obo/GO_0010639	negative regulation of organelle organization	http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization		Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.
http://purl.obolibrary.org/obo/GO_0010647	positive regulation of cell communication	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
http://purl.obolibrary.org/obo/GO_0010648	negative regulation of cell communication	http://purl.obolibrary.org/obo/GO_0010646	regulation of cell communication		Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
http://purl.obolibrary.org/obo/GO_0010694	positive regulation of alkaline phosphatase activity	http://purl.obolibrary.org/obo/GO_0010922	positive regulation of phosphatase activity		Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
http://purl.obolibrary.org/obo/GO_0010700	negative regulation of norepinephrine secretion	http://purl.obolibrary.org/obo/GO_0033604	negative regulation of catecholamine secretion		Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.
http://purl.obolibrary.org/obo/GO_0010701	positive regulation of norepinephrine secretion	http://purl.obolibrary.org/obo/GO_0033605	positive regulation of catecholamine secretion		Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.
http://purl.obolibrary.org/obo/GO_0010720	positive regulation of cell development	http://purl.obolibrary.org/obo/GO_0060284	regulation of cell development		Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
http://purl.obolibrary.org/obo/GO_0010721	negative regulation of cell development	http://purl.obolibrary.org/obo/GO_0060284	regulation of cell development		Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
http://purl.obolibrary.org/obo/GO_0010821	regulation of mitochondrion organization	http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization		Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
http://purl.obolibrary.org/obo/GO_0010892	positive regulation of mitochondrial translation in response to stress	http://purl.obolibrary.org/obo/GO_0070131	positive regulation of mitochondrial translation		Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress.
http://purl.obolibrary.org/obo/GO_0010893	positive regulation of steroid biosynthetic process	http://purl.obolibrary.org/obo/GO_0050810	regulation of steroid biosynthetic process		Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
http://purl.obolibrary.org/obo/GO_0010894	negative regulation of steroid biosynthetic process	http://purl.obolibrary.org/obo/GO_0051055	negative regulation of lipid biosynthetic process		Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
http://purl.obolibrary.org/obo/GO_0010907	positive regulation of glucose metabolic process	http://purl.obolibrary.org/obo/GO_0045913	positive regulation of carbohydrate metabolic process		Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
http://purl.obolibrary.org/obo/GO_0010921	regulation of phosphatase activity	http://purl.obolibrary.org/obo/GO_0051336	regulation of hydrolase activity		Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing phosphate.
http://purl.obolibrary.org/obo/GO_0010922	positive regulation of phosphatase activity	http://purl.obolibrary.org/obo/GO_0051345	positive regulation of hydrolase activity		Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
http://purl.obolibrary.org/obo/GO_0010923	negative regulation of phosphatase activity	http://purl.obolibrary.org/obo/GO_0051346	negative regulation of hydrolase activity		Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
http://purl.obolibrary.org/obo/GO_0010948	negative regulation of cell cycle process	http://purl.obolibrary.org/obo/GO_0045786	negative regulation of cell cycle		Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
http://purl.obolibrary.org/obo/GO_0010955	negative regulation of protein processing	http://purl.obolibrary.org/obo/GO_1903318	negative regulation of protein maturation		Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.
http://purl.obolibrary.org/obo/GO_0012506	vesicle membrane	http://purl.obolibrary.org/obo/GO_0031090	organelle membrane		The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
http://purl.obolibrary.org/obo/GO_0014003	oligodendrocyte development	http://purl.obolibrary.org/obo/GO_0021782	glial cell development		The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
http://purl.obolibrary.org/obo/GO_0014013	regulation of gliogenesis	http://purl.obolibrary.org/obo/GO_0050767	regulation of neurogenesis		Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.
http://purl.obolibrary.org/obo/GO_0014014	negative regulation of gliogenesis	http://purl.obolibrary.org/obo/GO_0014013	regulation of gliogenesis		Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.
http://purl.obolibrary.org/obo/GO_0014015	positive regulation of gliogenesis	http://purl.obolibrary.org/obo/GO_0014013	regulation of gliogenesis		Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.
http://purl.obolibrary.org/obo/GO_0014037	Schwann cell differentiation	http://purl.obolibrary.org/obo/GO_0010001	glial cell differentiation		The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
http://purl.obolibrary.org/obo/GO_0014038	regulation of Schwann cell differentiation	http://purl.obolibrary.org/obo/GO_0045685	regulation of glial cell differentiation		Any process that modulates the frequency, rate or extent of Schwann cell differentiation.
http://purl.obolibrary.org/obo/GO_0014039	negative regulation of Schwann cell differentiation	http://purl.obolibrary.org/obo/GO_0045686	negative regulation of glial cell differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation.
http://purl.obolibrary.org/obo/GO_0014040	positive regulation of Schwann cell differentiation	http://purl.obolibrary.org/obo/GO_0045687	positive regulation of glial cell differentiation		Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation.
http://purl.obolibrary.org/obo/GO_0014044	Schwann cell development	http://purl.obolibrary.org/obo/GO_0021782	glial cell development		The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
http://purl.obolibrary.org/obo/GO_0014047	glutamate secretion	http://purl.obolibrary.org/obo/GO_0015800	acidic amino acid transport		The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system.
http://purl.obolibrary.org/obo/GO_0014048	regulation of glutamate secretion	http://purl.obolibrary.org/obo/GO_0032890	regulation of organic acid transport		Any process that modulates the frequency, rate or extent of the controlled release of glutamate.
http://purl.obolibrary.org/obo/GO_0014049	positive regulation of glutamate secretion	http://purl.obolibrary.org/obo/GO_0014048	regulation of glutamate secretion		Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate.
http://purl.obolibrary.org/obo/GO_0014050	negative regulation of glutamate secretion	http://purl.obolibrary.org/obo/GO_0014048	regulation of glutamate secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate.
http://purl.obolibrary.org/obo/GO_0014051	gamma-aminobutyric acid secretion	http://purl.obolibrary.org/obo/GO_0015812	gamma-aminobutyric acid transport		The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues.
http://purl.obolibrary.org/obo/GO_0014052	regulation of gamma-aminobutyric acid secretion	http://purl.obolibrary.org/obo/GO_0032890	regulation of organic acid transport		Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
http://purl.obolibrary.org/obo/GO_0014053	negative regulation of gamma-aminobutyric acid secretion	http://purl.obolibrary.org/obo/GO_0014052	regulation of gamma-aminobutyric acid secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
http://purl.obolibrary.org/obo/GO_0014054	positive regulation of gamma-aminobutyric acid secretion	http://purl.obolibrary.org/obo/GO_0014052	regulation of gamma-aminobutyric acid secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid.
http://purl.obolibrary.org/obo/GO_0014055	acetylcholine secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0061526	acetylcholine secretion		The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS).
http://purl.obolibrary.org/obo/GO_0014056	regulation of acetylcholine secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0051952	regulation of amine transport		Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine.
http://purl.obolibrary.org/obo/GO_0014057	positive regulation of acetylcholine secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0051954	positive regulation of amine transport		Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine.
http://purl.obolibrary.org/obo/GO_0014058	negative regulation of acetylcholine secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0051953	negative regulation of amine transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine.
http://purl.obolibrary.org/obo/GO_0014060	regulation of epinephrine secretion	http://purl.obolibrary.org/obo/GO_0050433	regulation of catecholamine secretion		Any process that modulates the frequency, rate or extent of the regulated release of epinephrine.
http://purl.obolibrary.org/obo/GO_0014061	regulation of norepinephrine secretion	http://purl.obolibrary.org/obo/GO_0050433	regulation of catecholamine secretion		Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.
http://purl.obolibrary.org/obo/GO_0014062	regulation of serotonin secretion	http://purl.obolibrary.org/obo/GO_0043269	regulation of monoatomic ion transport		Any process that modulates the frequency, rate or extent of the regulated release of serotonin.
http://purl.obolibrary.org/obo/GO_0014063	negative regulation of serotonin secretion	http://purl.obolibrary.org/obo/GO_0043271	negative regulation of monoatomic ion transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
http://purl.obolibrary.org/obo/GO_0014064	positive regulation of serotonin secretion	http://purl.obolibrary.org/obo/GO_0043270	positive regulation of monoatomic ion transport		Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.
http://purl.obolibrary.org/obo/GO_0014819	regulation of skeletal muscle contraction	http://purl.obolibrary.org/obo/GO_0006942	regulation of striated muscle contraction		Any process that modulates the frequency, rate or extent of skeletal muscle contraction.
http://purl.obolibrary.org/obo/GO_0014821	phasic smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006939	smooth muscle contraction		A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations.
http://purl.obolibrary.org/obo/GO_0014827	intestine smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0014831	gastro-intestinal system smooth muscle contraction		A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.
http://purl.obolibrary.org/obo/GO_0014831	gastro-intestinal system smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006939	smooth muscle contraction		A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract).
http://purl.obolibrary.org/obo/GO_0014832	urinary bladder smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0014848	urinary tract smooth muscle contraction		A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
http://purl.obolibrary.org/obo/GO_0014848	urinary tract smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0006939	smooth muscle contraction		A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.
http://purl.obolibrary.org/obo/GO_0014852	regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction	http://purl.obolibrary.org/obo/GO_0014819	regulation of skeletal muscle contraction		Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system.
http://purl.obolibrary.org/obo/GO_0014853	regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction	http://purl.obolibrary.org/obo/GO_0098815	modulation of excitatory postsynaptic potential		Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
http://purl.obolibrary.org/obo/GO_0014860	neurotransmitter secretion involved in regulation of skeletal muscle contraction	http://purl.obolibrary.org/obo/GO_0007269	neurotransmitter secretion		The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
http://purl.obolibrary.org/obo/GO_0014861	regulation of skeletal muscle contraction via regulation of action potential	http://purl.obolibrary.org/obo/GO_0098900	regulation of action potential		Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.
http://purl.obolibrary.org/obo/GO_0015106	bicarbonate transmembrane transporter activity	http://purl.obolibrary.org/obo/GO_0022857	transmembrane transporter activity		Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
http://purl.obolibrary.org/obo/GO_0015669	gas transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015701	bicarbonate transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015721	bile acid and bile salt transport	http://purl.obolibrary.org/obo/GO_0006869	lipid transport		The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015800	acidic amino acid transport	http://purl.obolibrary.org/obo/GO_0006865	amino acid transport		The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015807	L-amino acid transport	http://purl.obolibrary.org/obo/GO_0006865	amino acid transport		The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015812	gamma-aminobutyric acid transport	http://purl.obolibrary.org/obo/GO_0006865	amino acid transport		The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015849	organic acid transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0015870	acetylcholine transport	http://purl.obolibrary.org/obo/GO_1901374	acetate ester transport		The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.
http://purl.obolibrary.org/obo/GO_0016079	synaptic vesicle exocytosis	http://purl.obolibrary.org/obo/GO_0099003	vesicle-mediated transport in synapse		Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
http://purl.obolibrary.org/obo/GO_0016137	glycoside metabolic process	http://purl.obolibrary.org/obo/GO_1901135	carbohydrate derivative metabolic process		The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.
http://purl.obolibrary.org/obo/GO_0016234	inclusion body	http://purl.obolibrary.org/obo/GO_0005622	intracellular anatomical structure		A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
http://purl.obolibrary.org/obo/GO_0016321	female meiosis chromosome segregation	http://purl.obolibrary.org/obo/GO_0045132	meiotic chromosome segregation		The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
http://purl.obolibrary.org/obo/GO_0016409	palmitoyltransferase activity	http://purl.obolibrary.org/obo/GO_0016747	acyltransferase activity, transferring groups other than amino-acyl groups		Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.
http://purl.obolibrary.org/obo/GO_0016469	proton-transporting two-sector ATPase complex	http://purl.obolibrary.org/obo/GO_0098796	membrane protein complex		A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.
http://purl.obolibrary.org/obo/GO_0016525	negative regulation of angiogenesis	http://purl.obolibrary.org/obo/GO_2000181	negative regulation of blood vessel morphogenesis		Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
http://purl.obolibrary.org/obo/GO_0016667	oxidoreductase activity, acting on a sulfur group of donors	http://purl.obolibrary.org/obo/GO_0016491	oxidoreductase activity		Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
http://purl.obolibrary.org/obo/GO_0016746	acyltransferase activity	http://purl.obolibrary.org/obo/GO_0016740	transferase activity		Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
http://purl.obolibrary.org/obo/GO_0016769	transferase activity, transferring nitrogenous groups	http://purl.obolibrary.org/obo/GO_0016740	transferase activity		Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).
http://purl.obolibrary.org/obo/GO_0017145	stem cell division	http://purl.obolibrary.org/obo/GO_0051301	cell division		The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.
http://purl.obolibrary.org/obo/GO_0017156	calcium-ion regulated exocytosis	http://purl.obolibrary.org/obo/GO_0045055	regulated exocytosis		The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
http://purl.obolibrary.org/obo/GO_0017158	regulation of calcium ion-dependent exocytosis	http://purl.obolibrary.org/obo/GO_1903305	regulation of regulated secretory pathway		Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.
http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
http://purl.obolibrary.org/obo/GO_0021782	glial cell development	http://purl.obolibrary.org/obo/GO_0048468	cell development		The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
http://purl.obolibrary.org/obo/GO_0030168	platelet activation	http://purl.obolibrary.org/obo/GO_0001775	cell activation		A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
http://purl.obolibrary.org/obo/GO_0030193	regulation of blood coagulation	http://purl.obolibrary.org/obo/GO_1900046	regulation of hemostasis		Any process that modulates the frequency, rate or extent of blood coagulation.
http://purl.obolibrary.org/obo/GO_0030195	negative regulation of blood coagulation	http://purl.obolibrary.org/obo/GO_0030193	regulation of blood coagulation		Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
http://purl.obolibrary.org/obo/GO_0030198	extracellular matrix organization	http://purl.obolibrary.org/obo/GO_0045229	external encapsulating structure organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
http://purl.obolibrary.org/obo/GO_0030225	macrophage differentiation	http://purl.obolibrary.org/obo/GO_1903131	mononuclear cell differentiation		The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.
http://purl.obolibrary.org/obo/GO_0030705	cytoskeleton-dependent intracellular transport	http://purl.obolibrary.org/obo/GO_0046907	intracellular transport		The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.
http://purl.obolibrary.org/obo/GO_0031090	organelle membrane	http://purl.obolibrary.org/obo/GO_0016020	membrane		A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
http://purl.obolibrary.org/obo/GO_0031344	regulation of cell projection organization	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
http://purl.obolibrary.org/obo/GO_0031346	positive regulation of cell projection organization	http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization		Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
http://purl.obolibrary.org/obo/GO_0031347	regulation of defense response	http://purl.obolibrary.org/obo/GO_0080134	regulation of response to stress		Any process that modulates the frequency, rate or extent of a defense response.
http://purl.obolibrary.org/obo/GO_0031514	motile cilium	http://purl.obolibrary.org/obo/GO_0005929	cilium		A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
http://purl.obolibrary.org/obo/GO_0031982	vesicle	http://purl.obolibrary.org/obo/GO_0043227	membrane-bounded organelle		Any small, fluid-filled, spherical organelle enclosed by membrane.
http://purl.obolibrary.org/obo/GO_0032056	positive regulation of translation in response to stress	http://purl.obolibrary.org/obo/GO_0045727	positive regulation of translation		Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.
http://purl.obolibrary.org/obo/GO_0032102	negative regulation of response to external stimulus	http://purl.obolibrary.org/obo/GO_0048585	negative regulation of response to stimulus		Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0032108	negative regulation of response to nutrient levels	http://purl.obolibrary.org/obo/GO_0032107	regulation of response to nutrient levels		Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels.
http://purl.obolibrary.org/obo/GO_0032222	regulation of synaptic transmission, cholinergic	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
http://purl.obolibrary.org/obo/GO_0032223	negative regulation of synaptic transmission, cholinergic	http://purl.obolibrary.org/obo/GO_0032222	regulation of synaptic transmission, cholinergic		Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
http://purl.obolibrary.org/obo/GO_0032224	positive regulation of synaptic transmission, cholinergic	http://purl.obolibrary.org/obo/GO_0032222	regulation of synaptic transmission, cholinergic		Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
http://purl.obolibrary.org/obo/GO_0032782	bile acid secretion	http://purl.obolibrary.org/obo/GO_0046717	acid secretion		The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0032879	regulation of localization	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
http://purl.obolibrary.org/obo/GO_0032885	regulation of polysaccharide biosynthetic process	http://purl.obolibrary.org/obo/GO_0032881	regulation of polysaccharide metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.
http://purl.obolibrary.org/obo/GO_0033047	regulation of mitotic sister chromatid segregation	http://purl.obolibrary.org/obo/GO_0033045	regulation of sister chromatid segregation		Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.
http://purl.obolibrary.org/obo/GO_0033604	negative regulation of catecholamine secretion	http://purl.obolibrary.org/obo/GO_0051953	negative regulation of amine transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.
http://purl.obolibrary.org/obo/GO_0033605	positive regulation of catecholamine secretion	http://purl.obolibrary.org/obo/GO_0051954	positive regulation of amine transport		Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.
http://purl.obolibrary.org/obo/GO_0034220	monoatomic ion transmembrane transport	http://purl.obolibrary.org/obo/GO_0055085	transmembrane transport		A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
http://purl.obolibrary.org/obo/GO_0034703	cation channel complex	http://purl.obolibrary.org/obo/GO_0034702	monoatomic ion channel complex		An ion channel complex through which cations pass.
http://purl.obolibrary.org/obo/GO_0035303	regulation of dephosphorylation	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule.
http://purl.obolibrary.org/obo/GO_0035305	negative regulation of dephosphorylation	http://purl.obolibrary.org/obo/GO_0045936	negative regulation of phosphate metabolic process		Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.
http://purl.obolibrary.org/obo/GO_0035306	positive regulation of dephosphorylation	http://purl.obolibrary.org/obo/GO_0035303	regulation of dephosphorylation		Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule.
http://purl.obolibrary.org/obo/GO_0042063	gliogenesis	http://purl.obolibrary.org/obo/GO_0022008	neurogenesis		The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
http://purl.obolibrary.org/obo/GO_0042360	vitamin E metabolic process	http://purl.obolibrary.org/obo/GO_0008152	metabolic process		The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.
http://purl.obolibrary.org/obo/GO_0042435	indole-containing compound biosynthetic process	http://purl.obolibrary.org/obo/GO_0009058	biosynthetic process		The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton.
http://purl.obolibrary.org/obo/GO_0042445	hormone metabolic process	http://purl.obolibrary.org/obo/GO_0010817	regulation of hormone levels		The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
http://purl.obolibrary.org/obo/GO_0042742	defense response to bacterium	http://purl.obolibrary.org/obo/GO_0009617	response to bacterium		Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
http://purl.obolibrary.org/obo/GO_0042749	regulation of circadian sleep/wake cycle	http://purl.obolibrary.org/obo/GO_0042752	regulation of circadian rhythm		Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
http://purl.obolibrary.org/obo/GO_0042752	regulation of circadian rhythm	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
http://purl.obolibrary.org/obo/GO_0042753	positive regulation of circadian rhythm	http://purl.obolibrary.org/obo/GO_0042752	regulation of circadian rhythm		Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
http://purl.obolibrary.org/obo/GO_0042762	regulation of sulfur metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.
http://purl.obolibrary.org/obo/GO_0043065	positive regulation of apoptotic process	http://purl.obolibrary.org/obo/GO_0043068	positive regulation of programmed cell death		Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
http://purl.obolibrary.org/obo/GO_0043067	regulation of programmed cell death	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
http://purl.obolibrary.org/obo/GO_0043068	positive regulation of programmed cell death	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
http://purl.obolibrary.org/obo/GO_0043228	membraneless organelle	http://purl.obolibrary.org/obo/GO_0043226	organelle		Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
http://purl.obolibrary.org/obo/GO_0043269	regulation of monoatomic ion transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0043270	positive regulation of monoatomic ion transport	http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport		Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0043271	negative regulation of monoatomic ion transport	http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0043558	regulation of translational initiation in response to stress	http://purl.obolibrary.org/obo/GO_0043555	regulation of translation in response to stress		Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress.
http://purl.obolibrary.org/obo/GO_0044085	cellular component biogenesis	http://purl.obolibrary.org/obo/GO_0071840	cellular component organization or biogenesis		A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.
http://purl.obolibrary.org/obo/GO_0044089	positive regulation of cellular component biogenesis	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.
http://purl.obolibrary.org/obo/GO_0044403	biological process involved in symbiotic interaction	http://purl.obolibrary.org/obo/GO_0044419	biological process involved in interspecies interaction between organisms		A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.
http://purl.obolibrary.org/obo/GO_0044419	biological process involved in interspecies interaction between organisms	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process evolved to enable an interaction with an organism of a different species.
http://purl.obolibrary.org/obo/GO_0045184	establishment of protein localization	http://purl.obolibrary.org/obo/GO_0051234	establishment of localization		The directed movement of a protein to a specific location.
http://purl.obolibrary.org/obo/GO_0045229	external encapsulating structure organization	http://purl.obolibrary.org/obo/GO_0016043	cellular component organization		A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.
http://purl.obolibrary.org/obo/GO_0045595	regulation of cell differentiation	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
http://purl.obolibrary.org/obo/GO_0045597	positive regulation of cell differentiation	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of cell differentiation.
http://purl.obolibrary.org/obo/GO_0045646	regulation of erythrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045637	regulation of myeloid cell differentiation		Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
http://purl.obolibrary.org/obo/GO_0045649	regulation of macrophage differentiation	http://purl.obolibrary.org/obo/GO_0002761	regulation of myeloid leukocyte differentiation		Any process that modulates the frequency, rate or extent of macrophage differentiation.
http://purl.obolibrary.org/obo/GO_0045650	negative regulation of macrophage differentiation	http://purl.obolibrary.org/obo/GO_0045649	regulation of macrophage differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.
http://purl.obolibrary.org/obo/GO_0045651	positive regulation of macrophage differentiation	http://purl.obolibrary.org/obo/GO_0045649	regulation of macrophage differentiation		Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
http://purl.obolibrary.org/obo/GO_0045685	regulation of glial cell differentiation	http://purl.obolibrary.org/obo/GO_0045595	regulation of cell differentiation		Any process that modulates the frequency, rate or extent of glia cell differentiation.
http://purl.obolibrary.org/obo/GO_0045686	negative regulation of glial cell differentiation	http://purl.obolibrary.org/obo/GO_0045685	regulation of glial cell differentiation		Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.
http://purl.obolibrary.org/obo/GO_0045687	positive regulation of glial cell differentiation	http://purl.obolibrary.org/obo/GO_0045685	regulation of glial cell differentiation		Any process that activates or increases the frequency, rate or extent of glia cell differentiation.
http://purl.obolibrary.org/obo/GO_0045727	positive regulation of translation	http://purl.obolibrary.org/obo/GO_0010628	positive regulation of gene expression		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
http://purl.obolibrary.org/obo/GO_0045765	regulation of angiogenesis	http://purl.obolibrary.org/obo/GO_1901342	regulation of vasculature development		Any process that modulates the frequency, rate or extent of angiogenesis.
http://purl.obolibrary.org/obo/GO_0045785	positive regulation of cell adhesion	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of cell adhesion.
http://purl.obolibrary.org/obo/GO_0045827	negative regulation of isoprenoid metabolic process	http://purl.obolibrary.org/obo/GO_0045833	negative regulation of lipid metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.
http://purl.obolibrary.org/obo/GO_0045861	negative regulation of proteolysis	http://purl.obolibrary.org/obo/GO_0051248	negative regulation of protein metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
http://purl.obolibrary.org/obo/GO_0045862	positive regulation of proteolysis	http://purl.obolibrary.org/obo/GO_0051247	positive regulation of protein metabolic process		Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
http://purl.obolibrary.org/obo/GO_0045912	negative regulation of carbohydrate metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
http://purl.obolibrary.org/obo/GO_0045913	positive regulation of carbohydrate metabolic process	http://purl.obolibrary.org/obo/GO_0009893	positive regulation of metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
http://purl.obolibrary.org/obo/GO_0045934	negative regulation of nucleobase-containing compound metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
http://purl.obolibrary.org/obo/GO_0045936	negative regulation of phosphate metabolic process	http://purl.obolibrary.org/obo/GO_0009892	negative regulation of metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
http://purl.obolibrary.org/obo/GO_0045939	negative regulation of steroid metabolic process	http://purl.obolibrary.org/obo/GO_0045833	negative regulation of lipid metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.
http://purl.obolibrary.org/obo/GO_0045940	positive regulation of steroid metabolic process	http://purl.obolibrary.org/obo/GO_0045834	positive regulation of lipid metabolic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.
http://purl.obolibrary.org/obo/GO_0045988	negative regulation of striated muscle contraction	http://purl.obolibrary.org/obo/GO_0045932	negative regulation of muscle contraction		Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.
http://purl.obolibrary.org/obo/GO_0045989	positive regulation of striated muscle contraction	http://purl.obolibrary.org/obo/GO_0045933	positive regulation of muscle contraction		Any process that activates or increases the frequency, rate or extent of striated muscle contraction.
http://purl.obolibrary.org/obo/GO_0046137	negative regulation of vitamin metabolic process	http://purl.obolibrary.org/obo/GO_0030656	regulation of vitamin metabolic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
http://purl.obolibrary.org/obo/GO_0046185	aldehyde catabolic process	http://purl.obolibrary.org/obo/GO_0009056	catabolic process		The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.
http://purl.obolibrary.org/obo/GO_0046886	positive regulation of hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0009891	positive regulation of biosynthetic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
http://purl.obolibrary.org/obo/GO_0046889	positive regulation of lipid biosynthetic process	http://purl.obolibrary.org/obo/GO_0009891	positive regulation of biosynthetic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
http://purl.obolibrary.org/obo/GO_0046929	negative regulation of neurotransmitter secretion	http://purl.obolibrary.org/obo/GO_1903531	negative regulation of secretion by cell		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter.
http://purl.obolibrary.org/obo/GO_0048242	epinephrine secretion	http://purl.obolibrary.org/obo/GO_0050432	catecholamine secretion		The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system.
http://purl.obolibrary.org/obo/GO_0048243	norepinephrine secretion	http://purl.obolibrary.org/obo/GO_0050432	catecholamine secretion		The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.
http://purl.obolibrary.org/obo/GO_0048520	positive regulation of behavior	http://purl.obolibrary.org/obo/GO_0050795	regulation of behavior		Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.
http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process	http://purl.obolibrary.org/obo/GO_0050794	regulation of cellular process		Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
http://purl.obolibrary.org/obo/GO_0048581	negative regulation of post-embryonic development	http://purl.obolibrary.org/obo/GO_0051241	negative regulation of multicellular organismal process		Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.
http://purl.obolibrary.org/obo/GO_0048582	positive regulation of post-embryonic development	http://purl.obolibrary.org/obo/GO_0051240	positive regulation of multicellular organismal process		Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.
http://purl.obolibrary.org/obo/GO_0048638	regulation of developmental growth	http://purl.obolibrary.org/obo/GO_0050793	regulation of developmental process		Any process that modulates the frequency, rate or extent of developmental growth.
http://purl.obolibrary.org/obo/GO_0048709	oligodendrocyte differentiation	http://purl.obolibrary.org/obo/GO_0010001	glial cell differentiation		The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
http://purl.obolibrary.org/obo/GO_0048878	chemical homeostasis	http://purl.obolibrary.org/obo/GO_0042592	homeostatic process		Any biological process involved in the maintenance of an internal steady state of a chemical.
http://purl.obolibrary.org/obo/GO_0050432	catecholamine secretion	http://purl.obolibrary.org/obo/GO_0032940	secretion by cell		The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
http://purl.obolibrary.org/obo/GO_0050433	regulation of catecholamine secretion	http://purl.obolibrary.org/obo/GO_0051952	regulation of amine transport		Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.
http://purl.obolibrary.org/obo/GO_0050767	regulation of neurogenesis	http://purl.obolibrary.org/obo/GO_0060284	regulation of cell development		Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
http://purl.obolibrary.org/obo/GO_0050790	regulation of catalytic activity	http://purl.obolibrary.org/obo/GO_0065009	regulation of molecular function		Any process that modulates the activity of an enzyme.
http://purl.obolibrary.org/obo/GO_0050810	regulation of steroid biosynthetic process	http://purl.obolibrary.org/obo/GO_0046890	regulation of lipid biosynthetic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
http://purl.obolibrary.org/obo/GO_0050879	multicellular organismal movement	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.
http://purl.obolibrary.org/obo/GO_0050910	detection of mechanical stimulus involved in sensory perception of sound	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0051049	regulation of transport	http://purl.obolibrary.org/obo/GO_0032879	regulation of localization		Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051050	positive regulation of transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051051	negative regulation of transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051055	negative regulation of lipid biosynthetic process	http://purl.obolibrary.org/obo/GO_0009890	negative regulation of biosynthetic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
http://purl.obolibrary.org/obo/GO_0051129	negative regulation of cellular component organization	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
http://purl.obolibrary.org/obo/GO_0051130	positive regulation of cellular component organization	http://purl.obolibrary.org/obo/GO_0048522	positive regulation of cellular process		Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
http://purl.obolibrary.org/obo/GO_0051336	regulation of hydrolase activity	http://purl.obolibrary.org/obo/GO_0050790	regulation of catalytic activity		Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
http://purl.obolibrary.org/obo/GO_0051341	regulation of oxidoreductase activity	http://purl.obolibrary.org/obo/GO_0050790	regulation of catalytic activity		Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
http://purl.obolibrary.org/obo/GO_0051345	positive regulation of hydrolase activity	http://purl.obolibrary.org/obo/GO_0051336	regulation of hydrolase activity		Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.
http://purl.obolibrary.org/obo/GO_0051346	negative regulation of hydrolase activity	http://purl.obolibrary.org/obo/GO_0051336	regulation of hydrolase activity		Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
http://purl.obolibrary.org/obo/GO_0051353	positive regulation of oxidoreductase activity	http://purl.obolibrary.org/obo/GO_0051341	regulation of oxidoreductase activity		Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
http://purl.obolibrary.org/obo/GO_0051494	negative regulation of cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0010639	negative regulation of organelle organization		Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
http://purl.obolibrary.org/obo/GO_0051495	positive regulation of cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0010638	positive regulation of organelle organization		Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
http://purl.obolibrary.org/obo/GO_0051606	detection of stimulus	http://purl.obolibrary.org/obo/GO_0050896	response to stimulus		The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.
http://purl.obolibrary.org/obo/GO_0051607	defense response to virus	http://purl.obolibrary.org/obo/GO_0009615	response to virus		Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
http://purl.obolibrary.org/obo/GO_0051952	regulation of amine transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051953	negative regulation of amine transport	http://purl.obolibrary.org/obo/GO_0051952	regulation of amine transport		Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0051954	positive regulation of amine transport	http://purl.obolibrary.org/obo/GO_0051952	regulation of amine transport		Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_0055117	regulation of cardiac muscle contraction	http://purl.obolibrary.org/obo/GO_0008016	regulation of heart contraction		Any process that modulates the frequency, rate or extent of cardiac muscle contraction.
http://purl.obolibrary.org/obo/GO_0060048	cardiac muscle contraction	http://purl.obolibrary.org/obo/GO_0006941	striated muscle contraction		Muscle contraction of cardiac muscle tissue.
http://purl.obolibrary.org/obo/GO_0060284	regulation of cell development	http://purl.obolibrary.org/obo/GO_0045595	regulation of cell differentiation		Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
http://purl.obolibrary.org/obo/GO_0060341	regulation of cellular localization	http://purl.obolibrary.org/obo/GO_0032879	regulation of localization		Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
http://purl.obolibrary.org/obo/GO_0060491	regulation of cell projection assembly	http://purl.obolibrary.org/obo/GO_0031344	regulation of cell projection organization		Any process that modulates the rate, frequency, or extent of cell projection assembly.
http://purl.obolibrary.org/obo/GO_0060627	regulation of vesicle-mediated transport	http://purl.obolibrary.org/obo/GO_0051049	regulation of transport		Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
http://purl.obolibrary.org/obo/GO_0061526	acetylcholine secretion	http://purl.obolibrary.org/obo/GO_0015870	acetylcholine transport		The regulated release of acetylcholine by a cell.
http://purl.obolibrary.org/obo/GO_0061696	pituitary gonadotropin complex	http://purl.obolibrary.org/obo/GO_0140392	extracellular protein-containing complex		A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function.
http://purl.obolibrary.org/obo/GO_0065009	regulation of molecular function	http://purl.obolibrary.org/obo/GO_0065007	biological regulation		Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
http://purl.obolibrary.org/obo/GO_0070131	positive regulation of mitochondrial translation	http://purl.obolibrary.org/obo/GO_0070129	regulation of mitochondrial translation		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
http://purl.obolibrary.org/obo/GO_0070507	regulation of microtubule cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0032886	regulation of microtubule-based process		Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
http://purl.obolibrary.org/obo/GO_0070613	regulation of protein processing	http://purl.obolibrary.org/obo/GO_1903317	regulation of protein maturation		Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.
http://purl.obolibrary.org/obo/GO_0071622	regulation of granulocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0002688	regulation of leukocyte chemotaxis		Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0071675	regulation of mononuclear cell migration	http://purl.obolibrary.org/obo/GO_0002685	regulation of leukocyte migration		Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_0071840	cellular component organization or biogenesis	http://purl.obolibrary.org/obo/GO_0009987	cellular process		A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
http://purl.obolibrary.org/obo/GO_0080134	regulation of response to stress	http://purl.obolibrary.org/obo/GO_0048583	regulation of response to stimulus		Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
http://purl.obolibrary.org/obo/GO_0090032	negative regulation of steroid hormone biosynthetic process	http://purl.obolibrary.org/obo/GO_0010894	negative regulation of steroid biosynthetic process		Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.
http://purl.obolibrary.org/obo/GO_0090068	positive regulation of cell cycle process	http://purl.obolibrary.org/obo/GO_0045787	positive regulation of cell cycle		Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
http://purl.obolibrary.org/obo/GO_0098590	plasma membrane region	http://purl.obolibrary.org/obo/GO_0016020	membrane		A membrane that is a (regional) part of the plasma membrane.
http://purl.obolibrary.org/obo/GO_0098609	cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0007155	cell adhesion		The attachment of one cell to another cell via adhesion molecules.
http://purl.obolibrary.org/obo/GO_0098754	detoxification	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
http://purl.obolibrary.org/obo/GO_0098815	modulation of excitatory postsynaptic potential	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
http://purl.obolibrary.org/obo/GO_0098900	regulation of action potential	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
http://purl.obolibrary.org/obo/GO_0099003	vesicle-mediated transport in synapse	http://purl.obolibrary.org/obo/GO_0016192	vesicle-mediated transport		Any vesicle-mediated transport that occurs in a synapse.
http://purl.obolibrary.org/obo/GO_0099111	microtubule-based transport	http://purl.obolibrary.org/obo/GO_0006810	transport		A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
http://purl.obolibrary.org/obo/GO_0099504	synaptic vesicle cycle	http://purl.obolibrary.org/obo/GO_0099003	vesicle-mediated transport in synapse		A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters.
http://purl.obolibrary.org/obo/GO_0100001	regulation of skeletal muscle contraction by action potential	http://purl.obolibrary.org/obo/GO_0014819	regulation of skeletal muscle contraction		Any action potential process that regulates skeletal muscle contraction.
http://purl.obolibrary.org/obo/GO_1901374	acetate ester transport	http://purl.obolibrary.org/obo/GO_0006810	transport		The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
http://purl.obolibrary.org/obo/GO_1902115	regulation of organelle assembly	http://purl.obolibrary.org/obo/GO_0033043	regulation of organelle organization		Any process that modulates the frequency, rate or extent of organelle assembly.
http://purl.obolibrary.org/obo/GO_1902116	negative regulation of organelle assembly	http://purl.obolibrary.org/obo/GO_1902115	regulation of organelle assembly		Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly.
http://purl.obolibrary.org/obo/GO_1902117	positive regulation of organelle assembly	http://purl.obolibrary.org/obo/GO_1902115	regulation of organelle assembly		Any process that activates or increases the frequency, rate or extent of organelle assembly.
http://purl.obolibrary.org/obo/GO_1902495	transmembrane transporter complex	http://purl.obolibrary.org/obo/GO_1990351	transporter complex		A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.
http://purl.obolibrary.org/obo/GO_1902531	regulation of intracellular signal transduction	http://purl.obolibrary.org/obo/GO_0009966	regulation of signal transduction		Any process that modulates the frequency, rate or extent of intracellular signal transduction.
http://purl.obolibrary.org/obo/GO_1902532	negative regulation of intracellular signal transduction	http://purl.obolibrary.org/obo/GO_1902531	regulation of intracellular signal transduction		Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.
http://purl.obolibrary.org/obo/GO_1902533	positive regulation of intracellular signal transduction	http://purl.obolibrary.org/obo/GO_1902531	regulation of intracellular signal transduction		Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.
http://purl.obolibrary.org/obo/GO_1903018	regulation of glycoprotein metabolic process	http://purl.obolibrary.org/obo/GO_0051246	regulation of protein metabolic process		Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.
http://purl.obolibrary.org/obo/GO_1903019	negative regulation of glycoprotein metabolic process	http://purl.obolibrary.org/obo/GO_1903018	regulation of glycoprotein metabolic process		Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.
http://purl.obolibrary.org/obo/GO_1903020	positive regulation of glycoprotein metabolic process	http://purl.obolibrary.org/obo/GO_1903018	regulation of glycoprotein metabolic process		Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.
http://purl.obolibrary.org/obo/GO_1903305	regulation of regulated secretory pathway	http://purl.obolibrary.org/obo/GO_0017157	regulation of exocytosis		Any process that modulates the frequency, rate or extent of regulated secretory pathway.
http://purl.obolibrary.org/obo/GO_1903318	negative regulation of protein maturation	http://purl.obolibrary.org/obo/GO_1903317	regulation of protein maturation		Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation.
http://purl.obolibrary.org/obo/GO_1903319	positive regulation of protein maturation	http://purl.obolibrary.org/obo/GO_1903317	regulation of protein maturation		Any process that activates or increases the frequency, rate or extent of protein maturation.
http://purl.obolibrary.org/obo/GO_1903430	negative regulation of cell maturation	http://purl.obolibrary.org/obo/GO_0010721	negative regulation of cell development		Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation.
http://purl.obolibrary.org/obo/GO_1903431	positive regulation of cell maturation	http://purl.obolibrary.org/obo/GO_0010720	positive regulation of cell development		Any process that activates or increases the frequency, rate or extent of cell maturation.
http://purl.obolibrary.org/obo/GO_1903828	negative regulation of protein localization	http://purl.obolibrary.org/obo/GO_0032880	regulation of protein localization		Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.
http://purl.obolibrary.org/obo/GO_2000181	negative regulation of blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_1901343	negative regulation of vasculature development		Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis.
http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process	http://purl.obolibrary.org/obo/GO_0050789	regulation of biological process		Any process that modulates the frequency, rate or extent of reproductive process.
http://purl.obolibrary.org/obo/GO_2000242	negative regulation of reproductive process	http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process		Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.
http://purl.obolibrary.org/obo/GO_2000243	positive regulation of reproductive process	http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process		Any process that activates or increases the frequency, rate or extent of reproductive process.
http://purl.obolibrary.org/obo/GO_2000300	regulation of synaptic vesicle exocytosis	http://purl.obolibrary.org/obo/GO_1903305	regulation of regulated secretory pathway		Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
http://purl.obolibrary.org/obo/GO_2000301	negative regulation of synaptic vesicle exocytosis	http://purl.obolibrary.org/obo/GO_2000300	regulation of synaptic vesicle exocytosis		Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis.
http://purl.obolibrary.org/obo/GO_2000302	positive regulation of synaptic vesicle exocytosis	http://purl.obolibrary.org/obo/GO_2000300	regulation of synaptic vesicle exocytosis		Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis.
http://purl.obolibrary.org/obo/GO_2000377	regulation of reactive oxygen species metabolic process	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
http://purl.obolibrary.org/obo/GO_2000378	negative regulation of reactive oxygen species metabolic process	http://purl.obolibrary.org/obo/GO_2000377	regulation of reactive oxygen species metabolic process		Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.
http://purl.obolibrary.org/obo/GO_2000379	positive regulation of reactive oxygen species metabolic process	http://purl.obolibrary.org/obo/GO_2000377	regulation of reactive oxygen species metabolic process		Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
http://purl.obolibrary.org/obo/GO_2000904	regulation of starch metabolic process	http://purl.obolibrary.org/obo/GO_0032881	regulation of polysaccharide metabolic process		Any process that modulates the frequency, rate or extent of starch metabolic process.
http://purl.obolibrary.org/obo/GO_0051938	L-glutamate import	http://purl.obolibrary.org/obo/GO_0015807	L-amino acid transport		The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle.
http://purl.obolibrary.org/obo/GO_0051966	regulation of synaptic transmission, glutamatergic	http://purl.obolibrary.org/obo/GO_0050804	modulation of chemical synaptic transmission		Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
http://purl.obolibrary.org/obo/GO_0051967	negative regulation of synaptic transmission, glutamatergic	http://purl.obolibrary.org/obo/GO_0051966	regulation of synaptic transmission, glutamatergic		Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
http://purl.obolibrary.org/obo/GO_0051968	positive regulation of synaptic transmission, glutamatergic	http://purl.obolibrary.org/obo/GO_0051966	regulation of synaptic transmission, glutamatergic		Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
http://purl.obolibrary.org/obo/GO_0051970	negative regulation of transmission of nerve impulse	http://purl.obolibrary.org/obo/GO_0010648	negative regulation of cell communication		Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
http://purl.obolibrary.org/obo/GO_0051971	positive regulation of transmission of nerve impulse	http://purl.obolibrary.org/obo/GO_0010647	positive regulation of cell communication		Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
http://purl.obolibrary.org/obo/GO_0055118	negative regulation of cardiac muscle contraction	http://purl.obolibrary.org/obo/GO_0055117	regulation of cardiac muscle contraction		Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.
http://purl.obolibrary.org/obo/GO_0055127	vibrational conductance of sound to the inner ear	http://purl.obolibrary.org/obo/GO_0032501	multicellular organismal process		The transmission of vibrations via ossicles to the inner ear.
http://purl.obolibrary.org/obo/GO_0060005	vestibular reflex	http://purl.obolibrary.org/obo/GO_0060004	reflex		A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.
http://purl.obolibrary.org/obo/GO_0060054	positive regulation of epithelial cell proliferation involved in wound healing	http://purl.obolibrary.org/obo/GO_0050679	positive regulation of epithelial cell proliferation		Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.
http://purl.obolibrary.org/obo/GO_0060055	angiogenesis involved in wound healing	http://purl.obolibrary.org/obo/GO_0001525	angiogenesis		Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury.
http://purl.obolibrary.org/obo/GO_0060073	micturition	http://purl.obolibrary.org/obo/GO_0003014	renal system process		The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.
http://purl.obolibrary.org/obo/GO_0060078	regulation of postsynaptic membrane potential	http://purl.obolibrary.org/obo/GO_0042391	regulation of membrane potential		Any process that modulates the potential difference across a post-synaptic membrane.
http://purl.obolibrary.org/obo/GO_0060082	eye blink reflex	http://purl.obolibrary.org/obo/GO_0060004	reflex		The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing.
http://purl.obolibrary.org/obo/GO_0060083	smooth muscle contraction involved in micturition	http://purl.obolibrary.org/obo/GO_0014832	urinary bladder smooth muscle contraction		The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body.
http://purl.obolibrary.org/obo/GO_0060084	synaptic transmission involved in micturition	http://purl.obolibrary.org/obo/GO_0007274	neuromuscular synaptic transmission		The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body.
http://purl.obolibrary.org/obo/GO_0060123	regulation of growth hormone secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell.
http://purl.obolibrary.org/obo/GO_0060124	positive regulation of growth hormone secretion	http://purl.obolibrary.org/obo/GO_0060123	regulation of growth hormone secretion		Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
http://purl.obolibrary.org/obo/GO_0060125	negative regulation of growth hormone secretion	http://purl.obolibrary.org/obo/GO_0060123	regulation of growth hormone secretion		Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.
http://purl.obolibrary.org/obo/GO_0060136	embryonic process involved in female pregnancy	http://purl.obolibrary.org/obo/GO_0048609	multicellular organismal reproductive process		A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.
http://purl.obolibrary.org/obo/GO_0060259	regulation of feeding behavior	http://purl.obolibrary.org/obo/GO_0050795	regulation of behavior		Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.
http://purl.obolibrary.org/obo/GO_0060263	regulation of respiratory burst	http://purl.obolibrary.org/obo/GO_0019222	regulation of metabolic process		Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0060264	regulation of respiratory burst involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0060263	regulation of respiratory burst		Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0060265	positive regulation of respiratory burst involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0060267	positive regulation of respiratory burst		Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0060266	negative regulation of respiratory burst involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0060268	negative regulation of respiratory burst		Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0060267	positive regulation of respiratory burst	http://purl.obolibrary.org/obo/GO_0060263	regulation of respiratory burst		Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0060268	negative regulation of respiratory burst	http://purl.obolibrary.org/obo/GO_0060263	regulation of respiratory burst		Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
http://purl.obolibrary.org/obo/GO_0060285	cilium-dependent cell motility	http://purl.obolibrary.org/obo/GO_0001539	cilium or flagellum-dependent cell motility		Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
http://purl.obolibrary.org/obo/GO_0060294	cilium movement involved in cell motility	http://purl.obolibrary.org/obo/GO_0003341	cilium movement		Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
http://purl.obolibrary.org/obo/GO_0060295	regulation of cilium movement involved in cell motility	http://purl.obolibrary.org/obo/GO_1902019	regulation of cilium-dependent cell motility		Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility.
http://purl.obolibrary.org/obo/GO_0060343	trabecula formation	http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis		The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
http://purl.obolibrary.org/obo/GO_0060349	bone morphogenesis	http://purl.obolibrary.org/obo/GO_0009887	animal organ morphogenesis		The process in which bones are generated and organized.
http://purl.obolibrary.org/obo/GO_0060374	mast cell differentiation	http://purl.obolibrary.org/obo/GO_0002573	myeloid leukocyte differentiation		The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.
http://purl.obolibrary.org/obo/GO_0060375	regulation of mast cell differentiation	http://purl.obolibrary.org/obo/GO_0002761	regulation of myeloid leukocyte differentiation		Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.
http://purl.obolibrary.org/obo/GO_0060376	positive regulation of mast cell differentiation	http://purl.obolibrary.org/obo/GO_0060375	regulation of mast cell differentiation		Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.
http://purl.obolibrary.org/obo/GO_0060377	negative regulation of mast cell differentiation	http://purl.obolibrary.org/obo/GO_0060375	regulation of mast cell differentiation		Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.
http://purl.obolibrary.org/obo/GO_0060405	regulation of penile erection	http://purl.obolibrary.org/obo/GO_2000241	regulation of reproductive process		Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.
http://purl.obolibrary.org/obo/GO_0060406	positive regulation of penile erection	http://purl.obolibrary.org/obo/GO_0060405	regulation of penile erection		Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.
http://purl.obolibrary.org/obo/GO_0060407	negative regulation of penile erection	http://purl.obolibrary.org/obo/GO_0060405	regulation of penile erection		Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.
http://purl.obolibrary.org/obo/GO_0060425	lung morphogenesis	http://purl.obolibrary.org/obo/GO_0009887	animal organ morphogenesis		The process in which the anatomical structures of the lung are generated and organized.
http://purl.obolibrary.org/obo/GO_0060428	lung epithelium development	http://purl.obolibrary.org/obo/GO_0060429	epithelium development		The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung.
http://purl.obolibrary.org/obo/GO_0060441	epithelial tube branching involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_0048754	branching morphogenesis of an epithelial tube		The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
http://purl.obolibrary.org/obo/GO_0060452	positive regulation of cardiac muscle contraction	http://purl.obolibrary.org/obo/GO_0055117	regulation of cardiac muscle contraction		Any process that increases the frequency, rate or extent of cardiac muscle contraction.
http://purl.obolibrary.org/obo/GO_0060453	regulation of gastric acid secretion	http://purl.obolibrary.org/obo/GO_0044058	regulation of digestive system process		Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
http://purl.obolibrary.org/obo/GO_0060454	positive regulation of gastric acid secretion	http://purl.obolibrary.org/obo/GO_0060453	regulation of gastric acid secretion		Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
http://purl.obolibrary.org/obo/GO_0060455	negative regulation of gastric acid secretion	http://purl.obolibrary.org/obo/GO_0060457	negative regulation of digestive system process		Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
http://purl.obolibrary.org/obo/GO_0060457	negative regulation of digestive system process	http://purl.obolibrary.org/obo/GO_0044058	regulation of digestive system process		Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
http://purl.obolibrary.org/obo/GO_0060462	lung lobe development	http://purl.obolibrary.org/obo/GO_0048856	anatomical structure development		The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung.
http://purl.obolibrary.org/obo/GO_0060463	lung lobe morphogenesis	http://purl.obolibrary.org/obo/GO_0009653	anatomical structure morphogenesis		The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.
http://purl.obolibrary.org/obo/GO_0060464	lung lobe formation	http://purl.obolibrary.org/obo/GO_0048646	anatomical structure formation involved in morphogenesis		The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung.
http://purl.obolibrary.org/obo/GO_0060474	positive regulation of flagellated sperm motility involved in capacitation	http://purl.obolibrary.org/obo/GO_1902093	positive regulation of flagellated sperm motility		The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence.
http://purl.obolibrary.org/obo/GO_0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_2000794	regulation of epithelial cell proliferation involved in lung morphogenesis		Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.
http://purl.obolibrary.org/obo/GO_0060502	epithelial cell proliferation involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_0050673	epithelial cell proliferation		The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.
http://purl.obolibrary.org/obo/GO_0060623	regulation of chromosome condensation	http://purl.obolibrary.org/obo/GO_0033044	regulation of chromosome organization		Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
http://purl.obolibrary.org/obo/GO_0060688	regulation of morphogenesis of a branching structure	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.
http://purl.obolibrary.org/obo/GO_0060764	cell-cell signaling involved in mammary gland development	http://purl.obolibrary.org/obo/GO_0007267	cell-cell signaling		Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure.
http://purl.obolibrary.org/obo/GO_0060784	regulation of cell proliferation involved in tissue homeostasis	http://purl.obolibrary.org/obo/GO_0042127	regulation of cell population proliferation		Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.
http://purl.obolibrary.org/obo/GO_0060785	regulation of apoptosis involved in tissue homeostasis	http://purl.obolibrary.org/obo/GO_0042981	regulation of apoptotic process		Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.
http://purl.obolibrary.org/obo/GO_0060786	regulation of cell differentiation involved in tissue homeostasis	http://purl.obolibrary.org/obo/GO_0045595	regulation of cell differentiation		Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue.
http://purl.obolibrary.org/obo/GO_0060916	mesenchymal cell proliferation involved in lung development	http://purl.obolibrary.org/obo/GO_0010463	mesenchymal cell proliferation		The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
http://purl.obolibrary.org/obo/GO_0061007	hepaticobiliary system process	http://purl.obolibrary.org/obo/GO_0003008	system process		A system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.
http://purl.obolibrary.org/obo/GO_0061046	regulation of branching involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_0060688	regulation of morphogenesis of a branching structure		Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
http://purl.obolibrary.org/obo/GO_0061047	positive regulation of branching involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_0061046	regulation of branching involved in lung morphogenesis		Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
http://purl.obolibrary.org/obo/GO_0061048	negative regulation of branching involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_0061046	regulation of branching involved in lung morphogenesis		Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
http://purl.obolibrary.org/obo/GO_0061116	ductus venosus closure	http://purl.obolibrary.org/obo/GO_0048845	venous blood vessel morphogenesis		The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth.
http://purl.obolibrary.org/obo/GO_0061326	renal tubule development	http://purl.obolibrary.org/obo/GO_0060429	epithelium development		The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
http://purl.obolibrary.org/obo/GO_0061383	trabecula morphogenesis	http://purl.obolibrary.org/obo/GO_0009653	anatomical structure morphogenesis		The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.
http://purl.obolibrary.org/obo/GO_0061512	protein localization to cilium	http://purl.obolibrary.org/obo/GO_0033365	protein localization to organelle		A process in which a protein is transported to, or maintained in, a location within a cilium.
http://purl.obolibrary.org/obo/GO_0061534	gamma-aminobutyric acid secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0014051	gamma-aminobutyric acid secretion		The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter.
http://purl.obolibrary.org/obo/GO_0061535	glutamate secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0051938	L-glutamate import		The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter.
http://purl.obolibrary.org/obo/GO_0070091	glucagon secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).
http://purl.obolibrary.org/obo/GO_0070092	regulation of glucagon secretion	http://purl.obolibrary.org/obo/GO_0090276	regulation of peptide hormone secretion		Any process that modulates the frequency, rate or extent of the regulated release of glucagon.
http://purl.obolibrary.org/obo/GO_0070093	negative regulation of glucagon secretion	http://purl.obolibrary.org/obo/GO_0070092	regulation of glucagon secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.
http://purl.obolibrary.org/obo/GO_0070094	positive regulation of glucagon secretion	http://purl.obolibrary.org/obo/GO_0070092	regulation of glucagon secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.
http://purl.obolibrary.org/obo/GO_0070124	mitochondrial translational initiation	http://purl.obolibrary.org/obo/GO_0006413	translational initiation		The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
http://purl.obolibrary.org/obo/GO_0070125	mitochondrial translational elongation	http://purl.obolibrary.org/obo/GO_0006414	translational elongation		The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.
http://purl.obolibrary.org/obo/GO_0070126	mitochondrial translational termination	http://purl.obolibrary.org/obo/GO_0006415	translational termination		The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).
http://purl.obolibrary.org/obo/GO_0070129	regulation of mitochondrial translation	http://purl.obolibrary.org/obo/GO_0006417	regulation of translation		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
http://purl.obolibrary.org/obo/GO_0070130	negative regulation of mitochondrial translation	http://purl.obolibrary.org/obo/GO_0070129	regulation of mitochondrial translation		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.
http://purl.obolibrary.org/obo/GO_0070132	regulation of mitochondrial translational initiation	http://purl.obolibrary.org/obo/GO_0070129	regulation of mitochondrial translation		Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.
http://purl.obolibrary.org/obo/GO_0070133	negative regulation of mitochondrial translational initiation	http://purl.obolibrary.org/obo/GO_0070132	regulation of mitochondrial translational initiation		Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.
http://purl.obolibrary.org/obo/GO_0070134	positive regulation of mitochondrial translational initiation	http://purl.obolibrary.org/obo/GO_0070132	regulation of mitochondrial translational initiation		Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.
http://purl.obolibrary.org/obo/GO_0070166	enamel mineralization	http://purl.obolibrary.org/obo/GO_0034505	tooth mineralization		The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.
http://purl.obolibrary.org/obo/GO_0070170	regulation of tooth mineralization	http://purl.obolibrary.org/obo/GO_0070167	regulation of biomineral tissue development		Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.
http://purl.obolibrary.org/obo/GO_0070171	negative regulation of tooth mineralization	http://purl.obolibrary.org/obo/GO_0070170	regulation of tooth mineralization		Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.
http://purl.obolibrary.org/obo/GO_0070172	positive regulation of tooth mineralization	http://purl.obolibrary.org/obo/GO_0070170	regulation of tooth mineralization		Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.
http://purl.obolibrary.org/obo/GO_0070173	regulation of enamel mineralization	http://purl.obolibrary.org/obo/GO_0070170	regulation of tooth mineralization		Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.
http://purl.obolibrary.org/obo/GO_0070174	negative regulation of enamel mineralization	http://purl.obolibrary.org/obo/GO_0070173	regulation of enamel mineralization		Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.
http://purl.obolibrary.org/obo/GO_0070175	positive regulation of enamel mineralization	http://purl.obolibrary.org/obo/GO_0070173	regulation of enamel mineralization		Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.
http://purl.obolibrary.org/obo/GO_0070253	somatostatin secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of somatostatin from secretory granules in the D cells of the pancreas.
http://purl.obolibrary.org/obo/GO_0070254	mucus secretion	http://purl.obolibrary.org/obo/GO_0032941	secretion by tissue		The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.
http://purl.obolibrary.org/obo/GO_0070255	regulation of mucus secretion	http://purl.obolibrary.org/obo/GO_0051239	regulation of multicellular organismal process		Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0070256	negative regulation of mucus secretion	http://purl.obolibrary.org/obo/GO_0070255	regulation of mucus secretion		Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0070257	positive regulation of mucus secretion	http://purl.obolibrary.org/obo/GO_0070255	regulation of mucus secretion		Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.
http://purl.obolibrary.org/obo/GO_0070451	cell hair	http://purl.obolibrary.org/obo/GO_0120025	plasma membrane bounded cell projection		A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located.
http://purl.obolibrary.org/obo/GO_0070459	prolactin secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.
http://purl.obolibrary.org/obo/GO_0070460	thyroid-stimulating hormone secretion	http://purl.obolibrary.org/obo/GO_0030072	peptide hormone secretion		The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary.
http://purl.obolibrary.org/obo/GO_0070527	platelet aggregation	http://purl.obolibrary.org/obo/GO_0034109	homotypic cell-cell adhesion		The adhesion of one platelet to one or more other platelets via adhesion molecules.
http://purl.obolibrary.org/obo/GO_0070857	regulation of bile acid biosynthetic process	http://purl.obolibrary.org/obo/GO_0050810	regulation of steroid biosynthetic process		Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
http://purl.obolibrary.org/obo/GO_0070858	negative regulation of bile acid biosynthetic process	http://purl.obolibrary.org/obo/GO_0070857	regulation of bile acid biosynthetic process		Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
http://purl.obolibrary.org/obo/GO_0070859	positive regulation of bile acid biosynthetic process	http://purl.obolibrary.org/obo/GO_0070857	regulation of bile acid biosynthetic process		Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
http://purl.obolibrary.org/obo/GO_0070942	neutrophil mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0002446	neutrophil mediated immunity		The directed killing of a target cell by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070943	neutrophil-mediated killing of symbiont cell	http://purl.obolibrary.org/obo/GO_0070942	neutrophil mediated cytotoxicity		The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
http://purl.obolibrary.org/obo/GO_0070944	neutrophil-mediated killing of bacterium	http://purl.obolibrary.org/obo/GO_0070943	neutrophil-mediated killing of symbiont cell		The directed killing of a bacterium by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070948	regulation of neutrophil mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0002886	regulation of myeloid leukocyte mediated immunity		Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070949	regulation of neutrophil mediated killing of symbiont cell	http://purl.obolibrary.org/obo/GO_0070948	regulation of neutrophil mediated cytotoxicity		Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070950	regulation of neutrophil mediated killing of bacterium	http://purl.obolibrary.org/obo/GO_0070949	regulation of neutrophil mediated killing of symbiont cell		Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070954	negative regulation of neutrophil mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0070948	regulation of neutrophil mediated cytotoxicity		Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070955	negative regulation of neutrophil mediated killing of symbiont cell	http://purl.obolibrary.org/obo/GO_0070954	negative regulation of neutrophil mediated cytotoxicity		Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070956	negative regulation of neutrophil mediated killing of bacterium	http://purl.obolibrary.org/obo/GO_0070955	negative regulation of neutrophil mediated killing of symbiont cell		Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070960	positive regulation of neutrophil mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0070948	regulation of neutrophil mediated cytotoxicity		Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070961	positive regulation of neutrophil mediated killing of symbiont cell	http://purl.obolibrary.org/obo/GO_0070960	positive regulation of neutrophil mediated cytotoxicity		Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil.
http://purl.obolibrary.org/obo/GO_0070962	positive regulation of neutrophil mediated killing of bacterium	http://purl.obolibrary.org/obo/GO_0070961	positive regulation of neutrophil mediated killing of symbiont cell		Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil.
http://purl.obolibrary.org/obo/GO_0071623	negative regulation of granulocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0071622	regulation of granulocyte chemotaxis		Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0071624	positive regulation of granulocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0071622	regulation of granulocyte chemotaxis		Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.
http://purl.obolibrary.org/obo/GO_0071625	vocalization behavior	http://purl.obolibrary.org/obo/GO_0007610	behavior		The behavior in which an organism produces sounds by a mechanism involving its respiratory system.
http://purl.obolibrary.org/obo/GO_0071626	mastication	http://purl.obolibrary.org/obo/GO_0022600	digestive system process		The process of biting and mashing food with the teeth prior to swallowing.
http://purl.obolibrary.org/obo/GO_0071676	negative regulation of mononuclear cell migration	http://purl.obolibrary.org/obo/GO_0071675	regulation of mononuclear cell migration		Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_0071677	positive regulation of mononuclear cell migration	http://purl.obolibrary.org/obo/GO_0071675	regulation of mononuclear cell migration		Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_0071707	immunoglobulin heavy chain V-D-J recombination	http://purl.obolibrary.org/obo/GO_0033152	immunoglobulin V(D)J recombination		The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
http://purl.obolibrary.org/obo/GO_0071708	immunoglobulin light chain V-J recombination	http://purl.obolibrary.org/obo/GO_0033152	immunoglobulin V(D)J recombination		The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).
http://purl.obolibrary.org/obo/GO_0071735	IgG immunoglobulin complex	http://purl.obolibrary.org/obo/GO_0019814	immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071736	IgG immunoglobulin complex, circulating	http://purl.obolibrary.org/obo/GO_0071735	IgG immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071738	IgD immunoglobulin complex	http://purl.obolibrary.org/obo/GO_0019814	immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071739	IgD immunoglobulin complex, circulating	http://purl.obolibrary.org/obo/GO_0071738	IgD immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071742	IgE immunoglobulin complex	http://purl.obolibrary.org/obo/GO_0019814	immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071743	IgE immunoglobulin complex, circulating	http://purl.obolibrary.org/obo/GO_0071742	IgE immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071745	IgA immunoglobulin complex	http://purl.obolibrary.org/obo/GO_0019814	immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071746	IgA immunoglobulin complex, circulating	http://purl.obolibrary.org/obo/GO_0071745	IgA immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071753	IgM immunoglobulin complex	http://purl.obolibrary.org/obo/GO_0019814	immunoglobulin complex		A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071754	IgM immunoglobulin complex, circulating	http://purl.obolibrary.org/obo/GO_0071753	IgM immunoglobulin complex		A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph.
http://purl.obolibrary.org/obo/GO_0071953	elastic fiber	http://purl.obolibrary.org/obo/GO_0099512	supramolecular fiber		An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.
http://purl.obolibrary.org/obo/GO_0071971	extracellular exosome assembly	http://purl.obolibrary.org/obo/GO_0070925	organelle assembly		The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm.
http://purl.obolibrary.org/obo/GO_0072201	negative regulation of mesenchymal cell proliferation	http://purl.obolibrary.org/obo/GO_0008285	negative regulation of cell population proliferation		Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.
http://purl.obolibrary.org/obo/GO_0072377	blood coagulation, common pathway	http://purl.obolibrary.org/obo/GO_0072376	protein activation cascade		A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated Factor Xa by either the intrinsic or extrinsic pathway, to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex.
http://purl.obolibrary.org/obo/GO_0097186	amelogenesis	http://purl.obolibrary.org/obo/GO_0042475	odontogenesis of dentin-containing tooth		The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.
http://purl.obolibrary.org/obo/GO_0097530	granulocyte migration	http://purl.obolibrary.org/obo/GO_0097529	myeloid leukocyte migration		The movement of a granulocyte within or between different tissues and organs of the body.
http://purl.obolibrary.org/obo/GO_0097712	trans-Golgi to periciliary membrane compartment transport	http://purl.obolibrary.org/obo/GO_0006893	Golgi to plasma membrane transport		The directed movement of substances from the trans-Golgi network to the periciliary membrane compartment, the specialized region of the plasma membrane surrounding the base of the cilium including the ciliary pocket, via vesicle-mediated transport.
http://purl.obolibrary.org/obo/GO_0097734	extracellular exosome biogenesis	http://purl.obolibrary.org/obo/GO_0140112	extracellular vesicle biogenesis		The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
http://purl.obolibrary.org/obo/GO_0098771	inorganic ion homeostasis	http://purl.obolibrary.org/obo/GO_0048878	chemical homeostasis		Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell.
http://purl.obolibrary.org/obo/GO_0099565	chemical synaptic transmission, postsynaptic	http://purl.obolibrary.org/obo/GO_0050877	nervous system process		The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.
http://purl.obolibrary.org/obo/GO_1901343	negative regulation of vasculature development	http://purl.obolibrary.org/obo/GO_1901342	regulation of vasculature development		Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.
http://purl.obolibrary.org/obo/GO_1902019	regulation of cilium-dependent cell motility	http://purl.obolibrary.org/obo/GO_2000145	regulation of cell motility		Any process that modulates the frequency, rate or extent of cilium-dependent cell motility.
http://purl.obolibrary.org/obo/GO_1902093	positive regulation of flagellated sperm motility	http://purl.obolibrary.org/obo/GO_2000243	positive regulation of reproductive process		Any process that activates or increases the frequency, rate or extent of flagellated sperm motility.
http://purl.obolibrary.org/obo/GO_1902338	negative regulation of apoptotic process involved in morphogenesis	http://purl.obolibrary.org/obo/GO_1904746	negative regulation of apoptotic process involved in development		Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.
http://purl.obolibrary.org/obo/GO_1902339	positive regulation of apoptotic process involved in morphogenesis	http://purl.obolibrary.org/obo/GO_1904747	positive regulation of apoptotic process involved in development		Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.
http://purl.obolibrary.org/obo/GO_1903296	positive regulation of glutamate secretion, neurotransmission	http://purl.obolibrary.org/obo/GO_0051968	positive regulation of synaptic transmission, glutamatergic		Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter.
http://purl.obolibrary.org/obo/GO_1903317	regulation of protein maturation	http://purl.obolibrary.org/obo/GO_0051246	regulation of protein metabolic process		Any process that modulates the frequency, rate or extent of protein maturation.
http://purl.obolibrary.org/obo/GO_1903489	positive regulation of lactation	http://purl.obolibrary.org/obo/GO_1903487	regulation of lactation		Any process that activates or increases the frequency, rate or extent of lactation.
http://purl.obolibrary.org/obo/GO_1903561	extracellular vesicle	http://purl.obolibrary.org/obo/GO_0031982	vesicle		Any vesicle that is part of the extracellular region.
http://purl.obolibrary.org/obo/GO_1905153	regulation of membrane invagination	http://purl.obolibrary.org/obo/GO_0051128	regulation of cellular component organization		Any process that modulates the frequency, rate or extent of membrane invagination.
http://purl.obolibrary.org/obo/GO_1905154	negative regulation of membrane invagination	http://purl.obolibrary.org/obo/GO_1905153	regulation of membrane invagination		Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination.
http://purl.obolibrary.org/obo/GO_1905155	positive regulation of membrane invagination	http://purl.obolibrary.org/obo/GO_1905153	regulation of membrane invagination		Any process that activates or increases the frequency, rate or extent of membrane invagination.
http://purl.obolibrary.org/obo/GO_1905276	regulation of epithelial tube formation	http://purl.obolibrary.org/obo/GO_2000026	regulation of multicellular organismal development		Any process that modulates the frequency, rate or extent of epithelial tube formation.
http://purl.obolibrary.org/obo/GO_1905278	positive regulation of epithelial tube formation	http://purl.obolibrary.org/obo/GO_1905276	regulation of epithelial tube formation		Any process that activates or increases the frequency, rate or extent of epithelial tube formation.
http://purl.obolibrary.org/obo/GO_1905349	ciliary transition zone assembly	http://purl.obolibrary.org/obo/GO_0022607	cellular component assembly		The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone.
http://purl.obolibrary.org/obo/GO_1905516	positive regulation of fertilization	http://purl.obolibrary.org/obo/GO_2000243	positive regulation of reproductive process		Any process that activates or increases the frequency, rate or extent of fertilization.
http://purl.obolibrary.org/obo/GO_1990748	cellular detoxification	http://purl.obolibrary.org/obo/GO_0098754	detoxification		Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
http://purl.obolibrary.org/obo/GO_2000543	positive regulation of gastrulation	http://purl.obolibrary.org/obo/GO_0010470	regulation of gastrulation		Any process that activates or increases the frequency, rate or extent of gastrulation.
http://purl.obolibrary.org/obo/GO_2000794	regulation of epithelial cell proliferation involved in lung morphogenesis	http://purl.obolibrary.org/obo/GO_0050678	regulation of epithelial cell proliferation		Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.
http://purl.obolibrary.org/obo/GO_2001013	epithelial cell proliferation involved in renal tubule morphogenesis	http://purl.obolibrary.org/obo/GO_0050673	epithelial cell proliferation		Any epithelial cell proliferation that is involved in renal tubule morphogenesis.
http://purl.obolibrary.org/obo/PR_000008946	insulin-like growth factor-binding protein complex acid labile chain	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human IGFALS gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000009054	preproinsulin	http://purl.obolibrary.org/obo/PR_000045358	insulin family protein		An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000009127	integrin alpha-IIb	http://purl.obolibrary.org/obo/PR_000025797	integrin alpha lacking A domain		An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000009143	integrin beta-7	http://purl.obolibrary.org/obo/PR_000001861	integrin beta		An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000009758	leptin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000009771	galectin-3	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human LGALS3 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000009978	lactotransferrin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000010379	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human MGAT2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000010479	72 kDa type IV collagenase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human MMP2 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000010761	mucin-16	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human MUC16 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000011649	5-oxoprolinase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human OPLAH gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000012234	phenylalanine-4-hydroxylase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PAH gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000012867	plasminogen	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PLG gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000013246	prolactin	http://purl.obolibrary.org/obo/PR_000029968	somatotropin hormone family member		A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000013275	vitamin K-dependent protein Z	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PROZ gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000013318	serine protease 1	http://purl.obolibrary.org/obo/PR_000027795	trypsin		A trypsin that is a translation product of the human PRSS1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000013429	parathyroid hormone	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000013883	renin	http://purl.obolibrary.org/obo/PR_000050025	angiotensinogenase		An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000014678	alpha-1-antitrypsin	http://purl.obolibrary.org/obo/PR_000025875	serpin		A serpin that is a translation product of the human SERPINA1 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000014686	corticosteroid-binding globulin	http://purl.obolibrary.org/obo/PR_000025875	serpin		A serpin that is a translation product of the human SERPINA6 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000014687	thyroxine-binding globulin	http://purl.obolibrary.org/obo/PR_000025875	serpin		A serpin that is a translation product of the human SERPINA7 gene or a 1:1 ortholog thereof.
http://purl.obolibrary.org/obo/PR_000025797	integrin alpha lacking A domain	http://purl.obolibrary.org/obo/PR_000025796	integrin alpha		An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains.
http://purl.obolibrary.org/obo/PR_000027795	trypsin	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that in active form is a serine protease that cleaves peptide bonds on the carboxyl side of lysine or arginine amino acids within amino acid chains.
http://purl.obolibrary.org/obo/PR_000045358	insulin family protein	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide.
http://purl.obolibrary.org/obo/PR_P61769	beta-2-microglobulin (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A beta-2-microglobulin that is encoded in the genome of human.
http://purl.obolibrary.org/obo/PR_P49747	cartilage oligomeric matrix protein (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A cartilage oligomeric matrix protein that is encoded in the genome of human.
http://purl.obolibrary.org/obo/CL_0001065	innate lymphoid cell	http://purl.obolibrary.org/obo/CL_0000542	lymphocyte		A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.
http://purl.obolibrary.org/obo/HP_0040297	Preauricular cyst	http://purl.obolibrary.org/obo/HP_0000383	Abnormal periauricular region morphology		Preauricular sinus is an occasional finding and most frequently appears as a small pit close to the anterior margin of the ascending portion of the helix. The opening has also been reported along the postero superior margin of the helix, the tragus or the lobule. Preauricular sinus may lead to the formation of a subcutaneous cyst that is intimately related to the tragal cartilage and the anterior crus of the helix.
http://purl.obolibrary.org/obo/UBERON_0036212	intertragic incisure	http://purl.obolibrary.org/obo/UBERON_0006846	surface groove		A surface structure that is the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by theantitragus, and along its lower lateral margins and inferior boundary by the connection between the first two.
http://purl.obolibrary.org/obo/UBERON_0036214	rectosigmoid junction	http://purl.obolibrary.org/obo/UBERON_8410024	intestinal junction		An anatomical junction that is between the sigmoid colon and rectum.
http://purl.obolibrary.org/obo/GO_0140096	catalytic activity, acting on a protein	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalytic activity that acts to modify a protein.
http://purl.obolibrary.org/obo/GO_0140098	catalytic activity, acting on RNA	http://purl.obolibrary.org/obo/GO_0140640	catalytic activity, acting on a nucleic acid		Catalytic activity that acts to modify RNA.
http://purl.obolibrary.org/obo/GO_0140101	catalytic activity, acting on a tRNA	http://purl.obolibrary.org/obo/GO_0140098	catalytic activity, acting on RNA		Catalytic activity that acts to modify a tRNA.
http://purl.obolibrary.org/obo/HP_0410309	Alpha-aminoadipic aciduria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The concentration of alpha-aminoadipic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410310	Abnormality of neutrophil morphology in CSF	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		An abnormal form or size of neutrophils in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0410311	Hyposegmentation of neutrophil nuclei in CSF	http://purl.obolibrary.org/obo/HP_0410310	Abnormality of neutrophil morphology in CSF		Hyposegmented (hypolobulated) or bilobed neutrophil nuclei in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0410312	Hypersegmentation of neutrophil nuclei in CSF	http://purl.obolibrary.org/obo/HP_0410310	Abnormality of neutrophil morphology in CSF		An excessive division of the lobes of the nucleus of a neutrophil in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0410313	Abnormal urinary 1-methylhistidine concentration	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		Abnormal concentration of 1-methylhistidine in the urine.
http://purl.obolibrary.org/obo/HP_0410314	Decreased urinary 1-methylhistidine	http://purl.obolibrary.org/obo/HP_0410313	Abnormal urinary 1-methylhistidine concentration		Decreased concentration of 1-methylhistidine in the urine.
http://purl.obolibrary.org/obo/HP_0410315	Increased urinary 1-methylhistidine	http://purl.obolibrary.org/obo/HP_0410313	Abnormal urinary 1-methylhistidine concentration		Increased concentration of 1-methylhistidine in the urine.
http://purl.obolibrary.org/obo/HP_0410316	Abnormal urinary 3-methylhistidine level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		Abnormal amount of 3-methylhistidine in the urine.
http://purl.obolibrary.org/obo/HP_0410317	Increased urinary 3-methylhistidine	http://purl.obolibrary.org/obo/HP_0410316	Abnormal urinary 3-methylhistidine level		Increased concentration of 3-methylhistidine in the urine.
http://purl.obolibrary.org/obo/HP_0410318	Decreased urinary 3-methylhistidine	http://purl.obolibrary.org/obo/HP_0410316	Abnormal urinary 3-methylhistidine level		Decreased concentration of 3-methylhistidine in the urine.
http://purl.obolibrary.org/obo/HP_0410319	Alpha-gal allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against alpha-gal.
http://purl.obolibrary.org/obo/HP_0410320	Animal protein allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against animal proteins.
http://purl.obolibrary.org/obo/HP_0410321	Animal dander allergy	http://purl.obolibrary.org/obo/HP_0410320	Animal protein allergy		Hypersensitivity in form of an adverse immune reaction against animal dander.
http://purl.obolibrary.org/obo/HP_0410322	Bacteria allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against bacteria.
http://purl.obolibrary.org/obo/HP_0410323	Drug allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against drugs.
http://purl.obolibrary.org/obo/HP_0410324	Dust mite allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against dust mites.
http://purl.obolibrary.org/obo/HP_0410326	Feather allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against feathers.
http://purl.obolibrary.org/obo/HP_0410328	Egg allergy	http://purl.obolibrary.org/obo/HP_0500093	Food allergy		Hypersensitivity in form of an adverse immune reaction against eggs.
http://purl.obolibrary.org/obo/HP_0410329	Gluten allergy	http://purl.obolibrary.org/obo/HP_0500093	Food allergy		Hypersensitivity in form of an adverse immune reaction against gluten.
http://purl.obolibrary.org/obo/HP_0410330	Meat allergen allergy	http://purl.obolibrary.org/obo/HP_0500093	Food allergy		Hypersensitivity in form of an adverse immune reaction against allergens contained in meat products.
http://purl.obolibrary.org/obo/HP_0410331	Nut food product allergy	http://purl.obolibrary.org/obo/HP_0410332	Plant based food allergy		Hypersensitivity in form of an adverse immune reaction against nut food products.
http://purl.obolibrary.org/obo/HP_0410332	Plant based food allergy	http://purl.obolibrary.org/obo/HP_0500093	Food allergy		Hypersensitivity in form of an adverse immune reaction against plant based food allergens.
http://purl.obolibrary.org/obo/HP_0410333	Seafood allergy	http://purl.obolibrary.org/obo/HP_0500093	Food allergy		Hypersensitivity in form of an adverse immune reaction against seafood.
http://purl.obolibrary.org/obo/HP_0410334	Fungi allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against fungus.
http://purl.obolibrary.org/obo/HP_0410335	Insect allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against insects.
http://purl.obolibrary.org/obo/HP_0410336	Venom allergy	http://purl.obolibrary.org/obo/HP_0410335	Insect allergy		Hypersensitivity in form of an adverse immune reaction against insect venom.
http://purl.obolibrary.org/obo/HP_0410337	Parasite allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against parasites.
http://purl.obolibrary.org/obo/HP_0410338	Plant product allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Hypersensitivity in form of an adverse immune reaction against plant products.
http://purl.obolibrary.org/obo/HP_0410339	Insect bite allergy	http://purl.obolibrary.org/obo/HP_0410335	Insect allergy		Hypersensitivity in form of an adverse immune reaction against insect bites.
http://purl.obolibrary.org/obo/HP_0410340	Focal epithelial hyperplasia of oral mucosa	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		The occurrence of multiple or unique whitish or normal in color small papules or nodules in oral cavity, especially on labial and buccal mucosa, lower lip and tongue, and less often on the upper lip, gingiva and palate.
http://purl.obolibrary.org/obo/HP_0410341	Abnormal circulating heparan sulfate concentration	http://purl.obolibrary.org/obo/HP_0011012	Abnormal circulating polysaccharide concentration		Any deviation from the normal concentration of heparan sulfate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0410342	Increased circulating heparan sulfate level	http://purl.obolibrary.org/obo/HP_0410341	Abnormal circulating heparan sulfate concentration		An abnormal increase in the concentration of heparan sulfate in the blood.
http://purl.obolibrary.org/obo/HP_0410343	Decreased circulating heparan sulfate concentration	http://purl.obolibrary.org/obo/HP_0410341	Abnormal circulating heparan sulfate concentration		The concentration of heparan sulfate in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0410344	Shortened O-fucosylated glycan on properdin	http://purl.obolibrary.org/obo/HP_0012359	Abnormal fucosylation of O-linked protein glycosylation		Decreased length of O-fucosylated glycans present on properdin.
http://purl.obolibrary.org/obo/HP_0410345	Increased urinary polyhexose	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		An abnormal increase in the concentration of polyhexose in the urine.
http://purl.obolibrary.org/obo/HP_0410346	Increased urinary galactosylated oligosaccharide	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		An abnormal increase in the concentration of galactosylated oligosaccharides in urine.
http://purl.obolibrary.org/obo/HP_0410347	Increased urinary high-mannose-type oligosaccharide	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		An abnormal increase in the concentration of high-mannose-type oligosaccharides in the urine.
http://purl.obolibrary.org/obo/HP_0410348	Increased urinary multiantennary sialylated oligosaccharide	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		An abnormal increase in the concentration of multiantennary sialylated oligosaccharides in the urine.
http://purl.obolibrary.org/obo/HP_0410349	Decreased glycosyltransferase O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormal decrease in glycosyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase enzymatic level.
http://purl.obolibrary.org/obo/HP_0410350	Increased urinary fucosylated oligosaccharide	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		An abnormal increase in the concentration of small fucosylated oligosaccharides in the urine.
http://purl.obolibrary.org/obo/HP_0410351	Abnormal complex N-glycan level	http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation		An abnormal concentration of complex N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410352	Increased complex N-glycan level	http://purl.obolibrary.org/obo/HP_0410351	Abnormal complex N-glycan level		An abnormal increase in the concentration of complex N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410353	Decreased complex N-glycan level	http://purl.obolibrary.org/obo/HP_0410351	Abnormal complex N-glycan level		An abnormal decrease in the concentration of complex N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410354	Increased sialylated N-glycan level	http://purl.obolibrary.org/obo/HP_0012349	Abnormal sialylation of N-linked protein glycosylation		An abnormal increase in the concentration of sialylated N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410355	Decreased sialylated N-glycan level	http://purl.obolibrary.org/obo/HP_0012349	Abnormal sialylation of N-linked protein glycosylation		An abnormal decrease in the concentration of sialylated N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410356	Abnormal high-mannose N-glycan level	http://purl.obolibrary.org/obo/HP_0012347	Abnormal protein N-linked glycosylation		An abnormal concentration of high-mannose N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410357	Increased high-mannose N-glycan level	http://purl.obolibrary.org/obo/HP_0410356	Abnormal high-mannose N-glycan level		An abnormal increase in the concentration of high-mannose N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410358	Decreased high-mannose N-glycan level	http://purl.obolibrary.org/obo/HP_0410356	Abnormal high-mannose N-glycan level		An abnormal decrease in the concentration of high-mannose N-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410359	Abnormal core 1 O-glycan level	http://purl.obolibrary.org/obo/HP_0012358	Abnormal protein O-linked glycosylation		An abnormal in the concentration of core 1 O-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410360	Increased core 1 O-glycan level	http://purl.obolibrary.org/obo/HP_0410359	Abnormal core 1 O-glycan level		An abnormal increase in the concentration of core 1 O-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410361	Decreased core 1 O-glycan level	http://purl.obolibrary.org/obo/HP_0410359	Abnormal core 1 O-glycan level		An abnormal decrease in the concentration of core 1 O-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410363	Increased monosialylated core 1 O-glycan level	http://purl.obolibrary.org/obo/HP_0012362	Abnormal sialylation of O-linked protein glycosylation		An abnormal increase in the concentration of monosialylated core 1 O-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410364	Decreased monosialylated core 1 O-glycan level	http://purl.obolibrary.org/obo/HP_0012362	Abnormal sialylation of O-linked protein glycosylation		An abnormal decrease in the concentration of monosialylated core 1 O-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410365	Increased disialylated core 1 O-glycan level	http://purl.obolibrary.org/obo/HP_0012362	Abnormal sialylation of O-linked protein glycosylation		An abnormal increase in the concentration of disialylated core 1 O-glycans on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410366	Increased globoside Gb4 level	http://purl.obolibrary.org/obo/HP_0004343	Abnormal glycosphingolipid metabolism		An abnormal increase in the concentration of globoside Gb4.
http://purl.obolibrary.org/obo/HP_0410368	Increased globoside Gb3 level	http://purl.obolibrary.org/obo/HP_0004343	Abnormal glycosphingolipid metabolism		An abnormal increase in the concentration of glycolipid globoside Gb3.
http://purl.obolibrary.org/obo/HP_0410370	Absence of ganglioside GM3	http://purl.obolibrary.org/obo/HP_0004343	Abnormal glycosphingolipid metabolism		The absence of ganglioside GM3.
http://purl.obolibrary.org/obo/HP_0410372	Increased Tn-antigen level	http://purl.obolibrary.org/obo/HP_0012358	Abnormal protein O-linked glycosylation		An abnormal increase in the concentration of Tn antigen on glycoproteins.
http://purl.obolibrary.org/obo/HP_0410373	Abnormal naive CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0031396	Abnormal naive T cell proportion		Abnormal increase or decrease of the naive CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
http://purl.obolibrary.org/obo/HP_0410374	Abnormal naive CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0031396	Abnormal naive T cell proportion		Abnormal increase or decrease of the naive CD8+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
http://purl.obolibrary.org/obo/HP_0410376	Increased naive CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410374	Abnormal naive CD8+ T cell proportion		Abnormal increase of the naive CD8+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
http://purl.obolibrary.org/obo/HP_0410377	Decreased naive CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410374	Abnormal naive CD8+ T cell proportion		Abnormal decrease of the naive CD8+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
http://purl.obolibrary.org/obo/HP_0410378	Decreased naive CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410373	Abnormal naive CD4+ T cell proportion		The proportion of naive CD4 T cells relative to the total number of T cells is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0410379	Abnormal memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0032182	Abnormal memory T cell proportion		Abnormal increase or decrease of the memory CD4+ T cell subpopulation, commonly characterized as CD45RA-, CD45RO+, or CD27-, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0410380	Abnormal memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0032182	Abnormal memory T cell proportion		Abnormal increase or decrease of the memory CD8+ T cell subpopulation, commonly characterized as CD45RA-, CD45RO+, or CD27-, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0410383	Abnormal effector memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410380	Abnormal memory CD8+ T cell proportion		An abnormal proportion of effector memory CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0410384	Abnormal central memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410380	Abnormal memory CD8+ T cell proportion		An abnormal proportion of central memory CD8-positive memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0410385	Decreased memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0032183	Decreased memory T cell proportion		Decreased proportion of CD8-positive memory T cells compared to the total number of T cells in the blood. A CD8-positive, alpha-beta T cell with memory phenotype is CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.
http://purl.obolibrary.org/obo/HP_0410386	Decreased CD4+ memory T cell proportion	http://purl.obolibrary.org/obo/HP_0032183	Decreased memory T cell proportion		Decresaed proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.
http://purl.obolibrary.org/obo/HP_0410388	Decreased central memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410386	Decreased CD4+ memory T cell proportion		A reduced proportion of central memory CD4-positive memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0410389	Decreased central memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410385	Decreased memory CD8+ T cell proportion		A reduced proportion of CD8-positive central memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0410390	Decreased effector memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410385	Decreased memory CD8+ T cell proportion		A reduced proportion of CD8-positive effector memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0410391	Increased memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0032184	Increased memory T cell proportion		Abnormal increase of the memory CD4+ T cell subpopulation, commonly characterized as CD45RA-, CD45RO+, or CD27-, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0410392	Increased memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0032184	Increased memory T cell proportion		Abnormal increase of the memory CD8+ T cell subpopulation, commonly characterized as CD45RA-, CD45RO+, or CD27-, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0410393	Increased central memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410391	Increased memory CD4+ T cell proportion		An abnormally elevated proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0410395	Increased effector memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410392	Increased memory CD8+ T cell proportion		An increased proportion of effector memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0410396	Increased central memory CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410392	Increased memory CD8+ T cell proportion		An increased proportion of central memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0500180	Abnormal circulating amino sulfonic acid concentration	http://purl.obolibrary.org/obo/HP_0033405	Abnormal circulating organic amino compound concentration		Any deviation from the normal concentration of amino sulfonic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0500181	Hypertaurinemia	http://purl.obolibrary.org/obo/HP_0500180	Abnormal circulating amino sulfonic acid concentration		An increased amount of taurine in the blood.
http://purl.obolibrary.org/obo/HP_0500182	Hypotaurinemia	http://purl.obolibrary.org/obo/HP_0500180	Abnormal circulating amino sulfonic acid concentration		A decreased amount of taurine in the blood.
http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Any deviation from the normal concentration of a carboxylic acid in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		Any deviation from the normal concentration of amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500185	Abnormal CSF branched chain amino acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of branched-chain amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500186	Abnormal CSF valine concentration	http://purl.obolibrary.org/obo/HP_0500185	Abnormal CSF branched chain amino acid concentration		Any deviation from the normal concentration of valine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500187	Increased CSF valine concentration	http://purl.obolibrary.org/obo/HP_0500186	Abnormal CSF valine concentration		Any increased amount from normal of valine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500188	Decreased CSF valine concentration	http://purl.obolibrary.org/obo/HP_0500186	Abnormal CSF valine concentration		Any decreased amount from normal of valine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500189	Abnormal CSF leucine concentration	http://purl.obolibrary.org/obo/HP_0500185	Abnormal CSF branched chain amino acid concentration		Any deviation from the normal concentration of leucine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500190	Decreased CSF leucine concentration	http://purl.obolibrary.org/obo/HP_0500189	Abnormal CSF leucine concentration		Abnormally decreased levels of leucine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500191	Increased CSF leucine concentration	http://purl.obolibrary.org/obo/HP_0500189	Abnormal CSF leucine concentration		Abnormally increased levels of leucine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500192	Abnormal CSF isoleucine concentration	http://purl.obolibrary.org/obo/HP_0500185	Abnormal CSF branched chain amino acid concentration		Any deviation from the normal concentration of isoleucine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500193	Increased CSF isoleucine concentration	http://purl.obolibrary.org/obo/HP_0500192	Abnormal CSF isoleucine concentration		Abnormally increased levels of isoleucine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500194	Decreased CSF isoleucine concentration	http://purl.obolibrary.org/obo/HP_0500192	Abnormal CSF isoleucine concentration		Abnormally decreased levels of isoleucine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500195	Abnormal CSF glutamine family amino acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of glutamine-family amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500196	Abnormal CSF glutamine concentration	http://purl.obolibrary.org/obo/HP_0500195	Abnormal CSF glutamine family amino acid concentration		Any deviation from the normal concentration of glutamine amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500197	Increased CSF glutamine concentration	http://purl.obolibrary.org/obo/HP_0500196	Abnormal CSF glutamine concentration		Abnormally increased levels of glutamine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500198	Decreased CSF glutamine concentration	http://purl.obolibrary.org/obo/HP_0500196	Abnormal CSF glutamine concentration		Abnormally decreased levels of glutamine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500199	Abnormal CSF glutamate concentration	http://purl.obolibrary.org/obo/HP_0500195	Abnormal CSF glutamine family amino acid concentration		Any deviation from the normal concentration of glutamic acid in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500200	Increased CSF glutamate concentration	http://purl.obolibrary.org/obo/HP_0500199	Abnormal CSF glutamate concentration		Abnormally increased levels of glutamic acid in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500201	Decreased CSF glutamate concentration	http://purl.obolibrary.org/obo/HP_0500199	Abnormal CSF glutamate concentration		Abnormally decreased levels of glutamic acid in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500202	Abnormal CSF arginine concentration	http://purl.obolibrary.org/obo/HP_0500195	Abnormal CSF glutamine family amino acid concentration		Any deviation from the normal concentration of arginine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500203	Increased CSF arginine concentration	http://purl.obolibrary.org/obo/HP_0500202	Abnormal CSF arginine concentration		Abnormally increased levels of arginine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500204	Decreased CSF arginine concentration	http://purl.obolibrary.org/obo/HP_0500202	Abnormal CSF arginine concentration		Abnormally decreased levels of arginine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500205	Abnormal CSF aspartate family amino acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of aspartate-family amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500206	Abnormal CSF lysine concentration	http://purl.obolibrary.org/obo/HP_0500205	Abnormal CSF aspartate family amino acid concentration		Any deviation from the normal concentration of lysine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500207	Decreased CSF lysine concentration	http://purl.obolibrary.org/obo/HP_0500206	Abnormal CSF lysine concentration		Abnormally decreased levels of lysine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500208	Increased CSF lysine concentration	http://purl.obolibrary.org/obo/HP_0500206	Abnormal CSF lysine concentration		Abnormally increased levels of lysine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500209	Abnormal CSF methionine concentration	http://purl.obolibrary.org/obo/HP_0500205	Abnormal CSF aspartate family amino acid concentration		Any deviation from the normal concentration of methionine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500210	Increased CSF methionine concentration	http://purl.obolibrary.org/obo/HP_0500209	Abnormal CSF methionine concentration		Concentration of methionine in the cerebrospinal fluid above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0500211	Abnormal CSF threonine concentration	http://purl.obolibrary.org/obo/HP_0500205	Abnormal CSF aspartate family amino acid concentration		Any deviation from the normal concentration of threonine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500212	Increased CSF threonine concentration	http://purl.obolibrary.org/obo/HP_0500211	Abnormal CSF threonine concentration		Abnormally increased levels of threonine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500213	Decreased CSF threonine concentration	http://purl.obolibrary.org/obo/HP_0500211	Abnormal CSF threonine concentration		Abnormally decreased levels of threonine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500214	Abnormal CSF aromatic amino acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of aromatic amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500215	Abnormal CSF phenylalanine concentration	http://purl.obolibrary.org/obo/HP_0500214	Abnormal CSF aromatic amino acid concentration		Any deviation from the normal concentration of phenylalanine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500216	Abnormal CSF aspartate concentration	http://purl.obolibrary.org/obo/HP_0500205	Abnormal CSF aspartate family amino acid concentration		Any deviation from the normal concentration of aspartic acid in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500217	Increased CSF aspartate concentration	http://purl.obolibrary.org/obo/HP_0500216	Abnormal CSF aspartate concentration		Abnormally increased levels of aspartic acid in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500218	Abnormal CSF tryptophan concentration	http://purl.obolibrary.org/obo/HP_0500214	Abnormal CSF aromatic amino acid concentration		Any deviation from the normal concentration of tryptophan in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500219	Abnormal CSF tyrosine concentration	http://purl.obolibrary.org/obo/HP_0500214	Abnormal CSF aromatic amino acid concentration		Any deviation from the normal concentration of tyrosine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500220	Increased CSF tyrosine concentration	http://purl.obolibrary.org/obo/HP_0500219	Abnormal CSF tyrosine concentration		Abnormally increased levels of tyrosine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500221	Decreased CSF tyrosine concentration	http://purl.obolibrary.org/obo/HP_0500219	Abnormal CSF tyrosine concentration		Abnormally decreased levels of tyrosine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500222	Increased CSF tryptophan concentration	http://purl.obolibrary.org/obo/HP_0500218	Abnormal CSF tryptophan concentration		Abnormally increased levels of tryptophan in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500223	Increased CSF phenylalanine concentration	http://purl.obolibrary.org/obo/HP_0500215	Abnormal CSF phenylalanine concentration		Abnormally increased levels of phenylalanine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500224	Decreased CSF phenylalanine concentration	http://purl.obolibrary.org/obo/HP_0500215	Abnormal CSF phenylalanine concentration		Abnormally decreased levels of phenylalanine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500225	Abnormal CSF serine family amino acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of serine-family amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500226	Abnormal CSF serine concentration	http://purl.obolibrary.org/obo/HP_0500225	Abnormal CSF serine family amino acid concentration		Any deviation from the normal concentration of serine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500227	Increased CSF serine concentration	http://purl.obolibrary.org/obo/HP_0500226	Abnormal CSF serine concentration		Abnormally increased levels of serine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500228	Decreased CSF serine concentration	http://purl.obolibrary.org/obo/HP_0500226	Abnormal CSF serine concentration		Abnormally decreased levels of serine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500229	Abnormal CSF glycine concentration	http://purl.obolibrary.org/obo/HP_0500225	Abnormal CSF serine family amino acid concentration		Any deviation from the normal concentration of glycine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500230	Increased CSF glycine concentration	http://purl.obolibrary.org/obo/HP_0500229	Abnormal CSF glycine concentration		Abnormally increased levels of glycine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500231	Abnormal CSF pyruvate family amino acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of pyruvate-family amino acids in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500232	Abnormal CSF alanine concentration	http://purl.obolibrary.org/obo/HP_0500231	Abnormal CSF pyruvate family amino acid concentration		Any deviation from the normal concentration of alanine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500233	Increased CSF alanine concentration	http://purl.obolibrary.org/obo/HP_0500232	Abnormal CSF alanine concentration		Abnormally increased levels of alanine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500234	Decreased CSF alanine concentration	http://purl.obolibrary.org/obo/HP_0500232	Abnormal CSF alanine concentration		Abnormally decreased levels of alanine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500235	Abnormal CSF histidine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of histidine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500236	Increased CSF histidine concentration	http://purl.obolibrary.org/obo/HP_0500235	Abnormal CSF histidine concentration		Abnormally increased levels of histidine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500237	Decreased CSF histidine concentration	http://purl.obolibrary.org/obo/HP_0500235	Abnormal CSF histidine concentration		Abnormally decreased levels of histidine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500240	Abnormal CSF carnosine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of carnosine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500241	Abnormal CSF homocarnosine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of homocarnosine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500242	Increased CSF homocarnosine concentration	http://purl.obolibrary.org/obo/HP_0500241	Abnormal CSF homocarnosine concentration		Abnormally increased levels of homocarnosine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500243	Abnormal CSF ornithine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of ornithine in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500244	Increased CSF ornithine concentration	http://purl.obolibrary.org/obo/HP_0500243	Abnormal CSF ornithine concentration		Abnormally increased levels of ornithine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500245	Abnormal CSF citrulline concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of citrulline in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500246	Increased CSF citrulline concentration	http://purl.obolibrary.org/obo/HP_0500245	Abnormal CSF citrulline concentration		Abnormally increased levels of citrulline in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500247	Abnormal CSF alpha-aminobutyrate concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Any deviation from the normal concentration of alpha-aminobutyrate in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0500248	Increased CSF alpha-aminobutyrate concentration	http://purl.obolibrary.org/obo/HP_0500247	Abnormal CSF alpha-aminobutyrate concentration		Concentration of alpha-aminobutyrate in the cerebrospinal fluid above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0500249	Abnormal circulating ethanolamine concentration	http://purl.obolibrary.org/obo/HP_0033405	Abnormal circulating organic amino compound concentration		Any deviation from the normal concentration of ethanolamine in circulation.
http://purl.obolibrary.org/obo/HP_0500250	Increased circulating ethanolamine concentration	http://purl.obolibrary.org/obo/HP_0500249	Abnormal circulating ethanolamine concentration		Abnormally increased levels of ethanolamine in circulation.
http://purl.obolibrary.org/obo/HP_0500251	Abnormal urine sebacic acid concentration	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Abnormal concentration of sebacic acid in the urine.
http://purl.obolibrary.org/obo/HP_0500252	Increased urine sebacic acid concentration	http://purl.obolibrary.org/obo/HP_0500251	Abnormal urine sebacic acid concentration		Elevated concentration of sebacic acid in the urine.
http://purl.obolibrary.org/obo/HP_0500253	Increased level of gamma-aminobutyric acid in urine	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		Elevated concentration of gamma-aminobutyric acid in the urine.
http://purl.obolibrary.org/obo/HP_0500254	Abnormal urine hexanoylglycine concentration	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Abnormal concentration of hexanoylglycine in the urine.
http://purl.obolibrary.org/obo/HP_0500255	Increased level of hexanoylglycine in urine	http://purl.obolibrary.org/obo/HP_0500254	Abnormal urine hexanoylglycine concentration		Elevated concentration of hexanoylglycine in the urine.
http://purl.obolibrary.org/obo/HP_0500256	Abnormal urine isobutyrylglycine concentration	http://purl.obolibrary.org/obo/HP_0012073	Abnormal urinary acylglycine profile		Abnormal concentration of isobutyrylglycine in the urine.
http://purl.obolibrary.org/obo/HP_0500257	Increased urine isobutyrylglycine concentration	http://purl.obolibrary.org/obo/HP_0500256	Abnormal urine isobutyrylglycine concentration		Elevated concentration of isobutyrylglycine in the urine.
http://purl.obolibrary.org/obo/PATO_0040047	fragmented	http://purl.obolibrary.org/obo/PATO_0001442	wholeness		Existing or functioning as though broken into separate parts; disorganized; disunified.
http://purl.obolibrary.org/obo/HP_0033216	Glomerular hyalinosis	http://purl.obolibrary.org/obo/HP_0033215	Obliterative abnormality of the renal glomerulus		Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus. Distribution can include vascular pole, perihilar, tip or neither tip, perihilar or vascular.
http://purl.obolibrary.org/obo/HP_0033217	Perihilar glomerular hyalinosis	http://purl.obolibrary.org/obo/HP_0033216	Glomerular hyalinosis		Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the vascular pole/perihilum.
http://purl.obolibrary.org/obo/HP_0033218	Glomerular hyalinosis at the tubular pole	http://purl.obolibrary.org/obo/HP_0033216	Glomerular hyalinosis		Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the tip/tubular pole.
http://purl.obolibrary.org/obo/HP_0033219	Glomerular hyalinosis away from the vascular and tubular poles	http://purl.obolibrary.org/obo/HP_0033216	Glomerular hyalinosis		Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at neither tip nor perihilar/vascular poles. Both the vascular and the tubular pole are present in the glomerular cross section.
http://purl.obolibrary.org/obo/HP_0033220	2-ethylhydracylic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An increased concentration of 2-ethylhydracylic acid in the urine.
http://purl.obolibrary.org/obo/HP_0033221	Increased CD4:CD8 ratio	http://purl.obolibrary.org/obo/HP_0031394	Abnormal CD4:CD8 ratio		An abnormal elevation of the relative proportion of CD4+ to CD8+ T cells.
http://purl.obolibrary.org/obo/HP_0033222	Inverted CD4:CD8 ratio	http://purl.obolibrary.org/obo/HP_0031394	Abnormal CD4:CD8 ratio		CD4:CD8 ratio less than 1, measured either as proportion of total CD3+ T cells, or in absolute numbers per microliter. These are usually measured within the TCR alpha/beta positive population. Normally there are relatively more CD4+ than CD8+ T cells.
http://purl.obolibrary.org/obo/HP_0033223	Abnormal glomerular parietal epithelial cell morphology	http://purl.obolibrary.org/obo/HP_0031264	Abnormal Bowman capsule morphology		Any structural abnormality of the parietal epithelial cells that line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells at the urinary pole and with the podocytes at the vascular pole.
http://purl.obolibrary.org/obo/HP_0033224	Glomerular parietal epithelial cell hyperplasia	http://purl.obolibrary.org/obo/HP_0033223	Abnormal glomerular parietal epithelial cell morphology		Increased number of parietal epithelial cells lining Bowman's capsule. Hyperplasia leads to the cells being present in 2 or more layers, often with crowding and multilayering.
http://purl.obolibrary.org/obo/HP_0033225	Glomerular parietal epithelial cell hypertrophy	http://purl.obolibrary.org/obo/HP_0033223	Abnormal glomerular parietal epithelial cell morphology		An abnormality of the glomerular parietal epithelial cells characterized by (1) Increased parietal epithelial cell size, with or without cytoplasmic protein droplets; or (2) enlarged nuclei with prominent nucleoli. Both features can be present
http://purl.obolibrary.org/obo/HP_0033226	Bowman capsular hyaline drops	http://purl.obolibrary.org/obo/HP_0031264	Abnormal Bowman capsule morphology		An insudative accumulation of amorphous, eosinophilic, periodic acid-Schiff (PAS)-positive, silver-negative material protruding from Bowman's capsule into the urinary space. Although not always evident by light microscopy, this material is located between Bowman's capsule and the parietal epithelial cells, in some cases associated with newly formed matrix material.
http://purl.obolibrary.org/obo/HP_0033227	Glomerular synechial adhesion	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		An area of basement membrane continuity between the glomerular tuft and Bowman's capsule, without intervening crescent and not adjacent to an area of segmental sclerosis.
http://purl.obolibrary.org/obo/HP_0033228	Triceps areflexia	http://purl.obolibrary.org/obo/HP_0012046	Areflexia of upper limbs		Inability to elicit triceps tendon reflex.
http://purl.obolibrary.org/obo/HP_0033229	Brachioradialis areflexia	http://purl.obolibrary.org/obo/HP_0012046	Areflexia of upper limbs		Inability to elicit brachioradialis tendon reflex.
http://purl.obolibrary.org/obo/HP_0033230	Biceps areflexia	http://purl.obolibrary.org/obo/HP_0012046	Areflexia of upper limbs		Inability to elicit biceps tendon reflex.
http://purl.obolibrary.org/obo/HP_0033231	Abnormal glomerular mesangial cellularity	http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology		Abnormal number of its constituent cells of the mesangium of the glomerulus of the kidney.
http://purl.obolibrary.org/obo/HP_0033232	Abnormal glomerular mesangial matrix morphology	http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology		Any structural anomaly of the glomerular matrix. Mesangial cells generate and embed in their own extracellular matrix. The mesangial matrix is different in composition from the glomerular basement membrane. Its constituents are type IV collagen (but only the alpha1 and alpha2 chains); type V collagen; laminin A, B1, and B2; and considerable amounts of fibronectin, heparan sulfate and chondroitin sulfate proteoglycans, entactin, and nidogen. Furthermore, small amounts of the proteoglycans decorin and biglycan are found in the mesangial matrix.
http://purl.obolibrary.org/obo/HP_0033233	Paramesangial deposits	http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology		Mesangial immune deposit located adjacent to the paramesangial glomerular basement membrane.
http://purl.obolibrary.org/obo/HP_0033234	Mesangial hyaline deposition	http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology		Extracellular mesangial accumulation of moderately electron-dense, generally homogenous, amorphous-appearing extracellular material.
http://purl.obolibrary.org/obo/HP_0033235	Difficulty descending stairs	http://purl.obolibrary.org/obo/HP_0004302	Functional motor deficit		Reduced ability to desscend stairs.
http://purl.obolibrary.org/obo/HP_0033236	Cognitive fatigue	http://purl.obolibrary.org/obo/HP_0012378	Fatigue		A failure to sustain attention that requires self-motivation to optimize performance.
http://purl.obolibrary.org/obo/HP_0033237	Visceral epithelial cell detachment	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Detachment of visceral epithelial cells (podocytes) from underlying glomerular basement membrane with intervening new loose basement membrane material (pale on Hematoxylin and eosin, periodic acid-Shiff, trichrome, or silver stain) forming a so-called 'halo'.
http://purl.obolibrary.org/obo/HP_0033238	Podocyte microvillous transformation	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Cytoplasmic projections into the urinary space from the luminal side of the podocyte.
http://purl.obolibrary.org/obo/HP_0033239	Visceral epithelial cell capping	http://purl.obolibrary.org/obo/HP_0020133	Podocyte hypertrophy		Layer of hypertrophied visceral epithelial cells overlying a sclerosed segment of the tuft of the glomerulus.
http://purl.obolibrary.org/obo/HP_0033240	Elevated RV/TLC ratio	http://purl.obolibrary.org/obo/HP_0033772	Abnormal RV/TLC ratio		An increase in the ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and (3) body plethysmography. An elevated RV/TLC can be interpreted as a sign of air trapping and hyperinflation.
http://purl.obolibrary.org/obo/HP_0033241	Polyalveolar lobe	http://purl.obolibrary.org/obo/HP_4000060	Abnormal pulmonary alveolar system development		An elevation of the total count of alveoli as determined by microscopic point-counting of randomly taken lung sections, not secondary to abnormalities in number, size and structure of the airways. In polyaveolar lobe, the number of alveoli is generally increased three to fivefold.
http://purl.obolibrary.org/obo/HP_0033242	Horseshoe lung	http://purl.obolibrary.org/obo/HP_0002101	Abnormal lung lobation		A horseshoe lung is an uncommon congenital abnormality caused by the partial fusion of the bases of both lungs behind the pericardial sac.
http://purl.obolibrary.org/obo/HP_0033243	Pulmonary necrosis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Cellular death affecting one or more parts of the lung. Necrosis is caused by diverse external and internal factors which result in the unregulated digestion of cell components.
http://purl.obolibrary.org/obo/HP_0033244	Glycogen accumulation in pulmonary interstitial cells	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Accumulation of immature interstitial cells containing abundant cytoplasmic glycogen defined by periodic acid-Schiff (PAS) positive cells.
http://purl.obolibrary.org/obo/HP_0033245	Abnormal alveolar type II pneumocyte morphology	http://purl.obolibrary.org/obo/HP_0033137	Abnormal pulmonary alveolar system morphology		Any structural abnormality of alveolar type 2 (ATII) cells.
http://purl.obolibrary.org/obo/HP_0033246	Type II pneumocyte hypertrophy	http://purl.obolibrary.org/obo/HP_0033245	Abnormal alveolar type II pneumocyte morphology		Increase in size of type II pneumocytes, characterized by qualitative morphologic alterations, including cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin.
http://purl.obolibrary.org/obo/HP_0033247	Pulmonary amyloidosis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Extracellular deposition in lung tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding.
http://purl.obolibrary.org/obo/HP_0033248	Multiple pulmonary interstitial hyalinized nodules	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Fibrosing nodules, consisting of either unilateral or bilateral central whorled deposits of lamellar collagen hyalin.
http://purl.obolibrary.org/obo/HP_0033249	Focal substantia nigra T2 hyperintensity	http://purl.obolibrary.org/obo/HP_0045007	Abnormal substantia nigra morphology		Hyperintense lesion in the substantia nigra on magnetic resonance T2 imaging.
http://purl.obolibrary.org/obo/HP_0033250	Nailfold capillary tortuosity	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		An increased number of turns of the blood vessels of the nailfold with a charactereistic winded or twisted appearance of the blood vessels.
http://purl.obolibrary.org/obo/HP_0033251	Elevated residual volume	http://purl.obolibrary.org/obo/HP_0033752	Abnormal residual volume		Increase in the amount of air remaining in a person's lungs after full exhalation.
http://purl.obolibrary.org/obo/HP_0033252	Palmar hyperlinearity	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		Exaggerated skin markings (dermatoglyphics) on the palms of the hand.
http://purl.obolibrary.org/obo/HP_0033253	Reduced circulating interferon gamma concentration	http://purl.obolibrary.org/obo/HP_0030355	Abnormal circulating interferon-gamma concentration		A reduction in the concentration of interferon gamma measured in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033254	Anorectal stricture	http://purl.obolibrary.org/obo/HP_0012732	Anorectal anomaly		Narrowing of the anorectum associated with inflammation or scar tissue.
http://purl.obolibrary.org/obo/HP_0033255	Congenital lobar overinflation	http://purl.obolibrary.org/obo/HP_0002101	Abnormal lung lobation		A congenital malformation characterized by an overdistended segment of lung, affecting an party of a lobe or the entire one. It results in progressive overinflation of one or more lobes.
http://purl.obolibrary.org/obo/HP_0033256	Pancolitis	http://purl.obolibrary.org/obo/HP_0002583	Colitis		Inflammation of the entire colon.
http://purl.obolibrary.org/obo/HP_0033257	Delayed ability to walk with support	http://purl.obolibrary.org/obo/HP_0002194	Delayed gross motor development		A failure to achieve the ability to walk with support (cruise) at an appropriate developmental stage.
http://purl.obolibrary.org/obo/HP_0033258	Sudden unexpected death in epilepsy	http://purl.obolibrary.org/obo/HP_0001699	Sudden death		Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death.
http://purl.obolibrary.org/obo/HP_0033260	Livedo racemosa	http://purl.obolibrary.org/obo/HP_0033832	Livedo		Livedo racemosa describes a reddish-blue mottling of the skin in an irregular, reticular pattern. It differs from the more common livedo reticularis by its shape. Livedo racemosa consists of broken circular segments resulting in a seemingly larger pattern, as opposed to the fine, regular, complete network of livedo reticularis. Livedo racemosa results from permanent impairment of peripheral blood flow and, unlike livedo reticularis, it persists on warming.
http://purl.obolibrary.org/obo/HP_0033261	Renal artery aneurysm	http://purl.obolibrary.org/obo/HP_0008776	Abnormal renal artery morphology		Increase in diameter of a segment of the renal artery that can be defined as a focal, isolated dilatation of all three layers of the arterial wall over 1.5 times the diameter of the disease-free proximal adjacent arterial segment.
http://purl.obolibrary.org/obo/HP_0033262	Transphyseal fracture of the distal humerus	http://purl.obolibrary.org/obo/HP_0041055	Fractured humerus		A fracture through the distal humeral physis that separates the entire distal humeral epiphysis from the metaphysis.
http://purl.obolibrary.org/obo/HP_0033263	Absent platelet dense granules	http://purl.obolibrary.org/obo/HP_0012530	Abnormal number of dense granules		Lack of platelet dense granules, a type of platelet organelles.
http://purl.obolibrary.org/obo/HP_0033264	Enlarged platelet dense granules	http://purl.obolibrary.org/obo/HP_0012484	Abnormal dense granules		Increased size of platelet dense granules.
http://purl.obolibrary.org/obo/HP_0033265	Podocyte myelin figures	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Lamellated intracytoplasmic lipid inclusions within podocytes.
http://purl.obolibrary.org/obo/HP_0033266	Glomerular pseudocrescent	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Visceral epithelial cell hyperplasia with resulting cellular crowding of the the urinary space. In contrast with true crescents, these proliferations lack inflammatory cells and fibrin. The cells are typically plump (not spindle-shaped) and often vacuolated, and Bowman's capsule is usually intact.
http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology	http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology		Abnormal structural characteristics of the interior space of the capillary of the renal glomerulus.
http://purl.obolibrary.org/obo/HP_0033268	Deflation of the glomerular tuft	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		Wrinkling and folding of the capillaries without epithelial cell (podocyte) hyperplasia (formerly called ischemic type of collapse) involving o 80% of the glomerular tuft. The wrinkling is generally made by small regular folds of the glomerular basement membrane.
http://purl.obolibrary.org/obo/HP_0033269	Glomerular capillary collapse	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		Collapse is generally accompanied by other descriptors such as hypertrophy and hyperplasia of overlying glomerular epithelial cells, halo, protein droplets in podocytes and glomerular parietal epithelial cells (PECs).
http://purl.obolibrary.org/obo/HP_0033270	Glomerular capillary congestion	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		Global distention of glomerular capillaries with intraluminal intact red blood cells.
http://purl.obolibrary.org/obo/HP_0033271	Glomerular capillary microaneurysm	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		Glomerular capillary dilatation due to loosening/detachment of the glomerular basement membrane (GBM) from its anchoring points, usually in the context of mesangiolysis or nodular glomerulosclerosis.
http://purl.obolibrary.org/obo/HP_0033272	Abnormal glomerular endothelial cell morphology	http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology		An abnormal structure of the glomerular endothelial cells, which are highly specialized cells with fenestrae and a charged luminal glycocalyx layer that contribute to the filtration barrier.
http://purl.obolibrary.org/obo/HP_0033273	Loss of glomerular endothelial cell fenestration	http://purl.obolibrary.org/obo/HP_0033272	Abnormal glomerular endothelial cell morphology		Loss of round to oval discontinuities normally present in the glomerular capillary endothelial cell cytoplasm.
http://purl.obolibrary.org/obo/HP_0033274	Glomerular endotheliosis	http://purl.obolibrary.org/obo/HP_0033272	Abnormal glomerular endothelial cell morphology		Enlargement of glomerular endothelial cells by cytoplasmic swelling with resulting partial or complete occlusion of the lumen.
http://purl.obolibrary.org/obo/HP_0033275	Glomerular endothelial tubuloreticular inclusion	http://purl.obolibrary.org/obo/HP_0033272	Abnormal glomerular endothelial cell morphology		Inter-anastomosing tubular structures located within cisternae of endoplasmic reticulum, most often within endothelial cells and associated with exposure to interferon.
http://purl.obolibrary.org/obo/HP_0033277	Glomerular fibrinoid necrosis	http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology		Fibrin associated with glomerular basement membrane disruption and/or lysis of the mesangial matrix; this lesion does not require the presence of karyorrhexis.
http://purl.obolibrary.org/obo/HP_0033278	Reduced CD95-induced lymphocyte apoptosis	http://purl.obolibrary.org/obo/HP_0002731	Decreased T cell apoptosis		Reduced amount of programmed cell death in peripheral blood lymphocytes following exposure to CD95 (APO-1/Fas), which is a member of the death receptor family, a subfamily of the TNF-R superfamily. Crosslinking of CD95 with its natural ligand CD95L (CD178) or with agonistic antibodies such as anti-APO-1 induces apoptosis in sensitive cells.
http://purl.obolibrary.org/obo/HP_0033279	Enterocutaneous fistula	http://purl.obolibrary.org/obo/HP_0100819	Intestinal fistula		An abnormal connection (fistula) between the intra-abdominal intestinal tract and the skin.
http://purl.obolibrary.org/obo/HP_0033280	Paratracheal lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Enlargement of lymph nodes surrounding the trachea.
http://purl.obolibrary.org/obo/HP_0033281	Circulating nucleated red blood cells	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		The presence of nucleated red blood cells in the peripheral blood circulation.
http://purl.obolibrary.org/obo/HP_0033283	Segmentally thickened glomerular basement membrane	http://purl.obolibrary.org/obo/HP_0033285	Thickened glomerular basement membranes with no electron dense deposits		Prominent glomerular basement membrane (GBM) reflecting a segmental and increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals.
http://purl.obolibrary.org/obo/HP_0033284	Diffusely thickened glomerular basement membrane	http://purl.obolibrary.org/obo/HP_0033285	Thickened glomerular basement membranes with no electron dense deposits		Prominent glomerular basement membrane (GBM) reflecting an diffuse and relatively uniform increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals.
http://purl.obolibrary.org/obo/HP_0033285	Thickened glomerular basement membranes with no electron dense deposits	http://purl.obolibrary.org/obo/HP_0004722	Thickened glomerular basement membrane		Prominent glomerular basement membrane (GBM) reflecting an increase in thickness (subjective estimate) with no evidence of electron dense deposits by electron microscopy.
http://purl.obolibrary.org/obo/HP_0033287	Glomerular basement membrane lucencies	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Lucent zones within the glomerular basement membranes. May reflect remote/resolved deposits.
http://purl.obolibrary.org/obo/HP_0033289	Glomerular basement membrane wrinkling	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Irregular folding of the glomerular basement membrane with an intact lamina densa.
http://purl.obolibrary.org/obo/HP_0033290	Glomerular subendothelial widening	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Expansion of the space between the glomerular endothelium and lamina densa by electron-lucent material.
http://purl.obolibrary.org/obo/HP_0033291	Glomerular karyhorrhectic debris	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		Apoptotic, pyknotic, and fragmented nuclei within the glomerulus.
http://purl.obolibrary.org/obo/HP_0033292	Glomerular fibrin thrombus	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		An aggregate of coagulated blood containing fibrin, with or without entrapped cellular elements, within a glomerular capillary lumen.
http://purl.obolibrary.org/obo/HP_0033293	Glomerular hyaline pseudothrombus	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		Intracapillary amorphous, eosinophilic material consisting of immune deposits.
http://purl.obolibrary.org/obo/HP_0033294	Glomerular lipoprotein thrombus	http://purl.obolibrary.org/obo/HP_0033267	Abnormal glomerular capillary lumen morphology		Intracapillary silver-positive material that is finely vacuolated and laminated, and stains with oil red O on frozen sections.
http://purl.obolibrary.org/obo/HP_0033295	Mesangial Immune complex deposition	http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology		Extracellular meangial accumulation of finely granular material corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry; most typically electron-dense although this may decrease with resorption of the deposit.
http://purl.obolibrary.org/obo/HP_0033296	Binucleated visceral epithelial cells	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Visceral epithelial cells with 2 nuclei. Can be observed on light or ultrastructral microscopy.
http://purl.obolibrary.org/obo/HP_0033297	Multinucleated visceral epithelial cells	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Visceral epithelial cells with more than two nuclei. Can be observed on light or ultrastructral microscopy.
http://purl.obolibrary.org/obo/HP_0033298	Abnormal circulating complement factor H-related protein 1 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of complement factor H-related protein 1 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033299	Decreased circulating complement factor H-related protein 1 concentration	http://purl.obolibrary.org/obo/HP_0033298	Abnormal circulating complement factor H-related protein 1 concentration		The concentration of complement factor H-related protein 1 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033300	Elevated circulating complement factor H-related protein 1 concentration	http://purl.obolibrary.org/obo/HP_0033298	Abnormal circulating complement factor H-related protein 1 concentration		The concentration of complement factor H-related protein 1 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033301	Elevated circulating 1-methylhistidine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An abnormally increased level of 1-methylhistidine in the blood circulation. 1-methylhistidine is a derivative of L-histidine.
http://purl.obolibrary.org/obo/HP_0033302	Elevated circulating 4-hydroxyphenylacetic acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of 4-Hydroxyphenylacetic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Abnormally increased amount of a monocarboxylic acid in the urine. Monocarboxylic acids are molecules with one COOH functional group.
http://purl.obolibrary.org/obo/HP_0033305	Abnormal circulating fetuin-A concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of fetuin-A in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033306	Decreased circulating fetuin-A concentration	http://purl.obolibrary.org/obo/HP_0033305	Abnormal circulating fetuin-A concentration		The concentration of fetuin-A in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033307	Elevated circulating fetuin-A concentration	http://purl.obolibrary.org/obo/HP_0033305	Abnormal circulating fetuin-A concentration		The concentration of fetuin-A in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033308	Patellar overgrowth	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		Excessive growth of the kneecap (patella).
http://purl.obolibrary.org/obo/HP_0033309	Ileoileal intussusception	http://purl.obolibrary.org/obo/HP_0002576	Intussusception		A type of intussusception of the small intestine in which one part of the ileum invaginates (telescopes) into another part of the ileum.
http://purl.obolibrary.org/obo/HP_0033310	Osmotic diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		Osmotic diarrhea results from the presence of osmotically active, poorly absorbed solutes in the bowel lumen that inhibit normal water and electrolyte absorption.
http://purl.obolibrary.org/obo/HP_0033311	Abdominal aortic dissection	http://purl.obolibrary.org/obo/HP_0002647	Aortic dissection		A tear in the intimal layer of the abdominal aorta causing a separation between the intima and the medial layers.
http://purl.obolibrary.org/obo/HP_0033312	Abnormal Bowman space morphology	http://purl.obolibrary.org/obo/HP_0031264	Abnormal Bowman capsule morphology		Structural anomaly located in Bowman's space, which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron.
http://purl.obolibrary.org/obo/HP_0033313	Urinary space collagenization	http://purl.obolibrary.org/obo/HP_0033312	Abnormal Bowman space morphology		Acellular collagenous matrix within Bowman's space, not associated with extracapillary hypercellularity or necrosis, associated with sclerosis or deflation of the tuft.
http://purl.obolibrary.org/obo/HP_0033314	Visceral epithelial cell hyperplasia	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Increased number of visceral epithelial cells (2 or more layers), often with crowding and multilayering, but without continuity with the parietal epithelium.
http://purl.obolibrary.org/obo/HP_0033315	Visceral epithelial hyaline droplets	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Round to ovoid, Periodic acid-Schiff (PAS)-positive, fuchsinophilic cytoplasmic inclusions within visceral epithelial cells.
http://purl.obolibrary.org/obo/HP_0033316	Glomerular crescent formation	http://purl.obolibrary.org/obo/HP_0033312	Abnormal Bowman space morphology		Glomerular crescent refers hyperplastic lesions involving 10% or more of the circumference of Bowman's capsule. Crescents can be composed of a variable mixture of epithelial/leukocyte hypercellularity, fibrous matrix, and fibrin.
http://purl.obolibrary.org/obo/HP_0033317	Cellular crescent	http://purl.obolibrary.org/obo/HP_0033316	Glomerular crescent formation		A type of glomerular crescent characterized by extracapillary hypercellularity of greater than two cell layers and involving more than 10% of the capsular circumference, composed of greater than 75% cells with or without fibrin, and less than 25% fibrous matrix.
http://purl.obolibrary.org/obo/HP_0033318	Fibrocellular crescent	http://purl.obolibrary.org/obo/HP_0033316	Glomerular crescent formation		A type of glomerular crescent characterized by extracapillary hypercellularity of more than 2 cell layers and involving over 10% of the capsular circumference, composed of 25% to 75% cells with or without fibrin, and the remainder fibrous matrix.
http://purl.obolibrary.org/obo/HP_0033319	Fibrous crescent	http://purl.obolibrary.org/obo/HP_0033316	Glomerular crescent formation		A type of glomerular crescent characterized by extracapillary fibrosis composed of greater than 75% matrix and of less than 25% cells with or without fibrin, usually associated with disruption of Bowman's capsule and involving over 10% of the capsular circumference.
http://purl.obolibrary.org/obo/HP_0033320	Mesangial cell loss	http://purl.obolibrary.org/obo/HP_0033231	Abnormal glomerular mesangial cellularity		Loss of mesangial cells segmentally or globally.
http://purl.obolibrary.org/obo/HP_0033321	Glomerular obsolescence	http://purl.obolibrary.org/obo/HP_0004737	Global glomerulosclerosis		Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium.
http://purl.obolibrary.org/obo/HP_0033322	Glomerular capillary wall duplication without cellular interposition	http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology		Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix, with or without endocapillary hypercellularity and no evidence of interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM.
http://purl.obolibrary.org/obo/HP_0033323	Glomerular capillary wall duplication with cellular interposition	http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology		Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix with interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM.
http://purl.obolibrary.org/obo/HP_0033324	Elevated circulating homovanillic acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of homovanillic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033325	Elevated circulating sebacic acid concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		Increased concentration of sebacic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033326	Elevated circulating hydroxyphenyllactic acid concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		An increased concentration of 4-hydroxyphenlyllactic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033327	Nail psoriasis	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Psoriatic nail abnormality characterized by the presence of neutrophils in the nail bed epithelium, hyperkeratosis with parakeratosis, presence of exudates on the corneal epithelium, focal hypogranulosis and psoriasiform hyperplasia of the nail bed.
http://purl.obolibrary.org/obo/HP_0033328	Type II pneumocyte hyperplasia	http://purl.obolibrary.org/obo/HP_0033245	Abnormal alveolar type II pneumocyte morphology		Increase in the number of type II pneumocytes.
http://purl.obolibrary.org/obo/HP_0033329	Abnormal postural reflex	http://purl.obolibrary.org/obo/HP_0031826	Abnormal reflex		Anomaly of the physiological response to maintain the body's posture when movement and position is altered.
http://purl.obolibrary.org/obo/HP_0033330	Impaired neck-righting reflex	http://purl.obolibrary.org/obo/HP_0033329	Abnormal postural reflex		Abnormal neck-righting response, which is said to be a physiological response when a child is placed flat on his or her back and the head is turned 90 degrees to the right or the left. With a normal neck-righting response, there follows a reflected torsion of the vertebral column in the same direction as the induced rotation of the neck. That is, the whole body follows the direction in which the head was turned. The response is present from birth to the age of five years.
http://purl.obolibrary.org/obo/HP_0033332	Elevated circulating serum amyloid A concentration	http://purl.obolibrary.org/obo/HP_0033331	Acute phase response		The concentration of serum amyloid A in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033333	Jaw contracture	http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology		Limitation of motion of the jaw due to structural changes in a muscle such as the massseter responsible for jaw movement.
http://purl.obolibrary.org/obo/HP_0033334	Abnormal embryonic development	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		An anomaly in the development of the embryo, that is, of the early developmental stage of development that follows the fertilization of an egg by sperm.
http://purl.obolibrary.org/obo/HP_0033335	Abnormal preimplantation embryonic development	http://purl.obolibrary.org/obo/HP_0033334	Abnormal embryonic development		An anomaly in the development of the embryo in a stage prior to implantation.
http://purl.obolibrary.org/obo/HP_0033336	Zygotic cleavage failure	http://purl.obolibrary.org/obo/HP_0033335	Abnormal preimplantation embryonic development		Failure of a fertilized oocyte to undergo the first round of cell division.
http://purl.obolibrary.org/obo/HP_0033337	Abnormal gametogenesis	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of reproductive system physiology		An anomaly in the process by a a haploid cell is formed from a diploid cells through meiosis. In males, diploid spermatogonia produce two haploid cells (secondary spermatocytes) in meiosis I and four haploid spermatids in meiosis II. In females, primordial germ cells under meiosis II before birth to form primary oocytes. Once puberty cell begins, these cells form secondary oocytes through meiosis II.
http://purl.obolibrary.org/obo/HP_0033338	Abnormal female meiosis	http://purl.obolibrary.org/obo/HP_0031515	Abnormal meiosis		Anomalous oocyte meiosis
http://purl.obolibrary.org/obo/HP_0033339	Increased circulating inosine concentration	http://purl.obolibrary.org/obo/HP_0004368	Elevated circulating purine concentration		An increased concentration of inosine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033340	Increased circulating guanosine concentration	http://purl.obolibrary.org/obo/HP_0004368	Elevated circulating purine concentration		Increased concentration of guanosine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033341	Elevated circulating sitosterol concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		An increased concentration of beta-sitosterol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033342	Anti-aquaporin 4 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against aquaporin-4.
http://purl.obolibrary.org/obo/HP_0033343	Mucoid diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		Passage of an increased number of stools containing mucus, a thick fluid substance secreted by mucous membranes.
http://purl.obolibrary.org/obo/HP_0033344	Pleural cobblestoning	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		A pleural cobblestone appearance characterized by irregular bumps surrounded by depressed lines in open lung biopsy. Caused by underlying scarring causing retraction of the interlobular septa where they insert on the pleura.
http://purl.obolibrary.org/obo/HP_0033349	Seizure cluster	http://purl.obolibrary.org/obo/HP_0031796	Recurrent		A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognizable by the primary clinician, carer or patient.
http://purl.obolibrary.org/obo/HP_0033350	Elevated forced expiratory volume in one second	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		An increase in the amount of air a person can forcefully expel in one second, compared to some standard or previous measure of same subject.
http://purl.obolibrary.org/obo/HP_0033351	Candida esophagitis	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Candida infections of the esophagus are considered opportunistic infections and are seen most commonly in immunosuppressed patients, the most common symptoms being dysphagia, odynophagia, and retrosternal pain.
http://purl.obolibrary.org/obo/HP_0033352	Pulmonary hypertensive crisis	http://purl.obolibrary.org/obo/HP_0004890	Elevated pulmonary artery pressure		Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output.
http://purl.obolibrary.org/obo/HP_0033355	Increased urine deoxypyridinoline level	http://purl.obolibrary.org/obo/HP_0033384	Elevated urinary collagen degradation products		An increased level of deoxypyridinoline in the urine. Deoxypyridinoline is a crosslink product of collagen molecules found in bone and excreted in urine during bone degradation, has been described as a marker of bone turnover.
http://purl.obolibrary.org/obo/HP_0033356	Elevated circulating o-phosphoserine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An abnormally increased level of o-phosphoserine in the blood circulation. o-phosphoserine is a derivative of serine.
http://purl.obolibrary.org/obo/HP_0033357	Limited head rotation	http://purl.obolibrary.org/obo/HP_0005986	Limitation of neck motion		Reduced range of motion turning the head side to side.
http://purl.obolibrary.org/obo/HP_0033359	Hyperosthenuria	http://purl.obolibrary.org/obo/HP_0033358	Abnormal urine osmolality		An abnormally high urinary specific gravity, i.e., increased concentration of solutes in the urine.
http://purl.obolibrary.org/obo/HP_0033360	Impaired ability to shift attention	http://purl.obolibrary.org/obo/HP_0033051	Impaired executive functioning		A behavioral abnormality whereby a person is unable to move freely from one situation, activity or aspect of aa problem to another as circumstances demand. Key aspects of shifting include the ability to make transitions, problem solve flexibly, switch or alternate attention, and change focus from one mind-set or topic to another. Mild deficits in the ability to shift compromise the efficiency of problem solving, whereas more severe difficulties are reflected in perseverative behaviors. Sometimes this is described as being rigid or inflexible.
http://purl.obolibrary.org/obo/HP_0033361	Nasal ulcer	http://purl.obolibrary.org/obo/HP_0000433	Abnormal nasal mucosa morphology		An open sore of the nasal mucosa.
http://purl.obolibrary.org/obo/GO_0140640	catalytic activity, acting on a nucleic acid	http://purl.obolibrary.org/obo/GO_0003824	catalytic activity		Catalytic activity that acts to modify a nucleic acid.
http://purl.obolibrary.org/obo/CHEBI_191197	branched-chain keto acid	http://purl.obolibrary.org/obo/CHEBI_25754	oxo carboxylic acid		An oxo carboxylic acid in which the parent hydrocarbon chain has one or more alkyl substituents. Derivatives formed from the first step in the metabolism of branched-chain amino acids and can provide important information on animal health and disease.
http://purl.obolibrary.org/obo/CHEBI_191874	fatty acid 26:0	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		A saturated fatty acid containing 26 carbons and 0 double bonds.
http://purl.obolibrary.org/obo/CL_4033000	endothelial cell of venule of lymph node	http://purl.obolibrary.org/obo/CL_1000414	endothelial cell of venule		A(n) endothelial cell that is part of a(n) venule of lymph node.
http://purl.obolibrary.org/obo/UBERON_8600004	visceral muscle tissue	http://purl.obolibrary.org/obo/UBERON_0002385	muscle tissue		A muscle tissue that is associated with soft internal organs (viscera).
http://purl.obolibrary.org/obo/CL_4033018	lung megakaryocyte	http://purl.obolibrary.org/obo/CL_0002320	connective tissue cell		A megakaryocyte that is resident in the lung connective tissue.
http://purl.obolibrary.org/obo/CL_4033054	perivascular cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics.
http://purl.obolibrary.org/obo/CL_4040004	mesenchymal stem cell of orbital adipose tissue	http://purl.obolibrary.org/obo/CL_0002570	mesenchymal stem cell of adipose tissue		Any mesenchymal stem cell of adipose tissue that is part of an orbital region.
http://purl.obolibrary.org/obo/CHEBI_228364	NMR chemical shift reference compound	http://purl.obolibrary.org/obo/CHEBI_747204	reference compound		Any compound that produces a peak used as reference frequency in the δ chemical shift scale.
http://purl.obolibrary.org/obo/GO_0170039	proteinogenic amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0006520	amino acid metabolic process		The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
http://purl.obolibrary.org/obo/HP_0430103	Past surgical history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		information about the patient's previous surgical treatments that might be relevant to the presenting illness or to provide optimal clinical management.
http://purl.obolibrary.org/obo/HP_0430104	Abnormal superficial temporal artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any structural abnormality of a superficial temporal artery, originating from the external carotid artery and passing over the zygomatic process. The superficial temporal artery is located on the superficial parts of the forehead and sides of the head and face.
http://purl.obolibrary.org/obo/HP_0430105	Skip lesions on temporal artery biopsy	http://purl.obolibrary.org/obo/HP_0430104	Abnormal superficial temporal artery morphology		Patchy inflammation of the superficial temporal artery, forming isolated foci of arteritis.
http://purl.obolibrary.org/obo/HP_0430107	Sputum infectious agent	http://purl.obolibrary.org/obo/HP_0430151	Positive respiratory tract infectious agent test		The presence of an infectious agent in the sputum, as characterized by sputum culture or other investigation.
http://purl.obolibrary.org/obo/HP_0430108	Positive Mycobacterium avium sputum culture	http://purl.obolibrary.org/obo/HP_0430107	Sputum infectious agent		Growth of mycobacterium avium in a sputum culture.
http://purl.obolibrary.org/obo/HP_0430109	Positive bloodstream infectious agent antigen test	http://purl.obolibrary.org/obo/HP_0430150	Positive blood infectious agent test		A test result demonstrating the presence of an antigen (marker such as a protein against which an antibody reacts) specific to an infectious agent.
http://purl.obolibrary.org/obo/HP_0430110	Positive bloodstream Cysticercosis antigen test	http://purl.obolibrary.org/obo/HP_0430109	Positive bloodstream infectious agent antigen test		Demonstration of an antigen specific to Cysticercosis in the bloodstream.
http://purl.obolibrary.org/obo/HP_0430111	Klazomania	http://purl.obolibrary.org/obo/HP_4000074	Involuntary vocalization		Involuntary attacks of compulsive paroxysmal shouting. The shouting behaviors may be extremely loud and not related to the ongoing mental state of the affected individual. Shouting episodes may occur in bouts and last for several hours.
http://purl.obolibrary.org/obo/HP_0430112	Coprolalia	http://purl.obolibrary.org/obo/HP_4000074	Involuntary vocalization		Coprolalia denotes the involuntary utterance of obscenities. Intent is an important classifier in coprolalic behaviors, and unfortunately it remains unclear how to objectively distinguish coprolalia from common swearing.
http://purl.obolibrary.org/obo/HP_0430113	Continuous involuntary vocalizations	http://purl.obolibrary.org/obo/HP_4000074	Involuntary vocalization		Continuous groaning, moaning, grunting, and shrieking.
http://purl.obolibrary.org/obo/HP_0430115	Cervical hypoplasia	http://purl.obolibrary.org/obo/HP_0430114	Aplasia/hypoplasia of the uterine cervix		Underdevelopment of the uterine cervix.
http://purl.obolibrary.org/obo/HP_0430116	Primary peritoneal serous papillary adenocarcinoma	http://purl.obolibrary.org/obo/HP_0034930	Digestive system neoplasm		A serous papillary adenocarcinoma that arises from the lining of the peritoneum
http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Any kind of test for an infectious agent in skin positive.
http://purl.obolibrary.org/obo/HP_0430118	Positive skin fungus test	http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test		A test for fungus, e.g., fungal hyphae, in a skin specimen (usually a skin scraping), demonstrates the presence of fungi. Most commonly, a skin scraping is obtained using a small scalpel blade, the specimen is placed on a clean glass slide, a drop of potassium hydroxide (KOH) is added, and the specimen is examined microscopically for fungal structures such as hyphae or yeast.
http://purl.obolibrary.org/obo/HP_0430119	Nasal secretion eosinophilia	http://purl.obolibrary.org/obo/HP_0031416	Abnormal nasal mucus secretion		Count of eosinophils in nasal secretions (for instance, nasal discharge) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0430120	Nasal secretion neutrophilia	http://purl.obolibrary.org/obo/HP_0031416	Abnormal nasal mucus secretion		Count of neutrophils in nasal secretions (for instance, nasal discharge) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0430121	Seminal vesicle agenesis	http://purl.obolibrary.org/obo/HP_6000190	Abnormal seminal vesicle morphology		A developmental defect characterized by congenital absence of the seminal vesicle.
http://purl.obolibrary.org/obo/HP_0430122	Head impulse test has corrective saccade	http://purl.obolibrary.org/obo/HP_0007670	Abnormal vestibulo-ocular reflex		In a patient with nystagmus, The examiner briskly rotates the head of the patient while having the patient fixate on a target. A corrective saccade indicates the patient's eye will move in one direction and quickly return back to neutral position.
http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Any kind of test for an infectious agent in the cerebrospinal fluid (CSF) positive.
http://purl.obolibrary.org/obo/HP_0430124	Positive CSF toxoplasma gondii nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of Toxoplasma gondii nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_0430125	Elevated circulating plasminogen activator inhibitor 1 activity	http://purl.obolibrary.org/obo/HP_0430126	Abnormal circulating plasminogen activator inhibitor 1 activity		The activity or concentration of plasminogen activator inhibitor-1 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0430126	Abnormal circulating plasminogen activator inhibitor 1 activity	http://purl.obolibrary.org/obo/HP_0040224	Abnormality of fibrinolysis		The activity or concentration of plasminogen activator inhibitor-1 in the blood circulation is outside of the limits of the normal range.
http://purl.obolibrary.org/obo/HP_0430127	Brain localization	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		The pattern by which a phenotype is localized to or predominant in a part of the brain.
http://purl.obolibrary.org/obo/HP_0430128	Frontal cortical localization	http://purl.obolibrary.org/obo/HP_0430127	Brain localization		Localization to or predominance in the frontal cortex of the brain.
http://purl.obolibrary.org/obo/HP_0430129	Posterior fossa localization	http://purl.obolibrary.org/obo/HP_0430127	Brain localization		Localization to or predominance in the parts of the brain within the posterior fossa.
http://purl.obolibrary.org/obo/HP_0430130	Subcortical localization	http://purl.obolibrary.org/obo/HP_0430127	Brain localization		Localization to or predominance in the subcortical region of the brain.
http://purl.obolibrary.org/obo/HP_0430131	Parietal cortex localization	http://purl.obolibrary.org/obo/HP_0430127	Brain localization		Localization to or predominance in the parietal cortex of the brain.
http://purl.obolibrary.org/obo/HP_0430132	Occipital cortex localization	http://purl.obolibrary.org/obo/HP_0430127	Brain localization		Localization to or predominance in the occipital cortex of the brain.
http://purl.obolibrary.org/obo/HP_0430133	Tobacco use history	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of use of tobacco products such as cigarettes.
http://purl.obolibrary.org/obo/HP_0430134	Bartholin cyst	http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology		A fluid-filled sac near the vaginal opening. A Bartholin cyst is usually unilateral, asymptomatic blockage of the Bartholin gland, which may lead to a painless swelling.
http://purl.obolibrary.org/obo/HP_0430136	Reduced circulating aspartate aminotransferase concentration	http://purl.obolibrary.org/obo/HP_0430135	Abnormal circulating hepatic transaminase concentration		The concentration of aspartate aminotransferase (AST) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0430137	Elevated urine succinic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of succinic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0430138	Positive CSF varicella zoster virus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test		Detection of Varicella zoster virus nucleic acid in the cerebrospinal fluid (CSF) by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_0430139	CSF pathogen-specific antibody positivity	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		Positive serology in the cerebrospinal fluid (CSF) for a exposure to an infectious agent (i.e., examining CSF for the presence of pathogen-specific antibodies).
http://purl.obolibrary.org/obo/HP_0430140	Positive CSF nucleic acid pathogen test	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		Positive (abnormal) result of a cerebrospinal fluid (CSF) test such as polymerase chain reaction that is targeted against a nucleic acid sequence specific for a pathogen.
http://purl.obolibrary.org/obo/HP_0430141	CSF varicella zoster antibody positivity	http://purl.obolibrary.org/obo/HP_0430139	CSF pathogen-specific antibody positivity		The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of varicella zoster virus.
http://purl.obolibrary.org/obo/HP_0430142	Reduced circulating interleukin 6 concentration	http://purl.obolibrary.org/obo/HP_6000441	Abnormal circulating interleukin 6 concentration		The concentration of interleukin-6 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000277	Elevated CSF beta-alanine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		The concentration of beta-alanine present in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000278	Elevated circulating 2-aminoadipic acid concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		The concentration of 2-aminoadipic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000279	Elevated urinary N-carbamoyl-beta-alanine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of N-carbamoyl-beta-alanine present in urine, when adjusted for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000280	Elevated CSF cystathionine concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		Concentration of cystathionine in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000281	Elevated urinary gamma-glutamylphenylalanine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of gamma-glutamylphenylalanine in the urine, when normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000282	Elevated circulating aspartylglucosamine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		Concentration of aspartylglucosamine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000283	Elevated urinary saccharopine level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of saccharopine in the urine, when normalized to urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000284	Tectal plate enlargement	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		Abnormal increase in size of the tectal plate (also known as the tectum or the quadrigeminal plate). The tectum is the dorsal portion of the midbrain (brainstem).
http://purl.obolibrary.org/obo/HP_6000285	Retroperitoneal mass	http://purl.obolibrary.org/obo/HP_0002012	Abnormality of the abdominal organs		A swelling or enlargement localized to the retroperitoneal region. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000286	Focal T1 hyperintense brainstem lesion	http://purl.obolibrary.org/obo/HP_0012747	Abnormal brainstem MRI signal intensity		A lighter than expected T1 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hyperintensity affecting a particular region of the brainstem.
http://purl.obolibrary.org/obo/HP_6000287	Subchondral fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of fracture that occurs in the trabecular cancellous bone just beneath the subchondral bone plate without disruption of the articular surface.
http://purl.obolibrary.org/obo/HP_6000288	Deep neck abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		An abscess (i.e., a circumscribed area of pus or necrotic debris) localized in the area surrounded by the deep fascia of the neck including the pharynx, larynx, trachea, upper esophagus, thyroid, and parathyroid glands. Infections of pharyngeal, tonsillar, and laryngeal origin affect this space, which includes the parapharyngeal and retropharyngeal spaces.
http://purl.obolibrary.org/obo/HP_6000289	Epiglottic enlargement	http://purl.obolibrary.org/obo/HP_0005483	Abnormal epiglottis morphology		Anlarged and edematous epiglottis. This sign can be observed on a lateral radiograph of the neck and it suggests a diagnosis of acute infectious epiglottitis.
http://purl.obolibrary.org/obo/HP_6000290	Prevertebral space enlargement	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		Increase in the anterior posterior dimension of the prevertebral space, which is located in the neck region between the anterior part of the cervical spine and the deep layer of the deep cervical fascia running between the transverse processes of the spine.
http://purl.obolibrary.org/obo/HP_6000291	Third cranial nerve thickening	http://purl.obolibrary.org/obo/HP_0025735	Abnormal third cranial nerve morphology		Increase in diameter of the third cranial nerve (oculomotor nerve). This feature can be observed by magnetic resonance imaging and may be accompanied by contrast enhancement.
http://purl.obolibrary.org/obo/HP_6000292	Elevated tissue sphingomyelin concentration	http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration		Concentration of sphoingomyelin in tissues above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000293	History of recent iodated contrast medium administration	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of recent iodinated or radioiodine contrast use.
http://purl.obolibrary.org/obo/HP_6000294	Difficulty passing nasogastric tube	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		Difficulty inserting a nasogastric tube (NGT), a flexible plastic tube that is placed through the nose and esophagus into the stomach and used to administer drugs or for feeding. There are certain circumstances that may make NGT insertion difficult. They are esophageal narrowing, comatose or intubated patients, and patients who have sustained severe facial or skull injuries.
http://purl.obolibrary.org/obo/HP_6000295	Persistent falcine venous sinus	http://purl.obolibrary.org/obo/HP_0033723	Abnormal cerebral venous sinus morphology		A falcine sinus that does not involute but persists beyond birth is defined as a persistent falcine sinus. In the 20-mm embryo stage, the primitive falx cerebri contains the sagittal plexus, a meshwork of anastomotic venous channels from which the superior sagittal sinus and straight sinus are thought to develop. A persistent falcine sinus represents a persistent channel of the caudal anastomotic loops of the sagittal plexus.
http://purl.obolibrary.org/obo/HP_6000296	Penis uncircumcised	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		A medical history in a male of not having been circumcized.
http://purl.obolibrary.org/obo/HP_6000297	History of facial cosmetic use	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A medical history of use of facial makeup.
http://purl.obolibrary.org/obo/HP_6000298	Snapping sensation at metacarpophalangeal joint	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		A feeling of clicking or snapping at the knuckle (metacarpophalangeal joint) upon extension of flexion of the finger.
http://purl.obolibrary.org/obo/HP_6000299	Forearm pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the forearm.
http://purl.obolibrary.org/obo/HP_6000300	Rotational fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		A type of displaced fracture in which there has been a rotation of the distal fracture fragment in relation to the proximal portion.
http://purl.obolibrary.org/obo/HP_6000301	Localized over bony prominences	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated on the skin in areas where bones are close to the surface (bony prominences).
http://purl.obolibrary.org/obo/HP_6000302	History of compressive footwear	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A past medical history of wearing tight shoes, toe-box shoes, or high heel shoes.
http://purl.obolibrary.org/obo/HP_6000303	Decreased skin turgor	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Reduced skin turgor means reduced elastic recoil of the skin to its normal contour after being pinched in a fold.
http://purl.obolibrary.org/obo/HP_6000304	Recent foraged mushroom consumption	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		Medical history of recently eating wild mushrooms.
http://purl.obolibrary.org/obo/HP_6000305	Proximal to distal progression	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Refers to symptomatology that begins in the proximal limbs and subsequently affects the distal limbs.
http://purl.obolibrary.org/obo/HP_6000306	Autonomic-voluntary dissociation of facial movements	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		The selective paralysis of voluntary fascio-pharyngo-glosso-masticatory movements with preservation of reflexive and automatic functions is referred to as autonomic-voluntary dissociation, which is a distinctive feature of Anterior opercular syndrome (also known as Foix-Chavany-Marie syndrome).
http://purl.obolibrary.org/obo/HP_6000307	Jaw mass	http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology		A swelling or enlargement localized to the jaw. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000308	Excessive nocturnal light exposure	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Exposure to continuous light at night, including night-shift work or a nocturnal lifestyle.
http://purl.obolibrary.org/obo/HP_6000309	Menstruating female between menarche and menopause	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Past medical history of a woman who is menstruating, i.e., not premenstrual or post-menopause.
http://purl.obolibrary.org/obo/HP_6000310	Preterm premature rupture of membranes	http://purl.obolibrary.org/obo/HP_0001788	Premature rupture of membranes		PPROM (preterm premature rupture of membranes) occurs at less than 37 weeks of gestation. PPROM can happen spontaneously, during preterm labor, or following a procedure such as amniocentesis.
http://purl.obolibrary.org/obo/HP_6000311	History of abdominal surgery	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A past medical history that indicates that the patient had a surgical procedure involving the abdomen.
http://purl.obolibrary.org/obo/HP_6000312	Thickened Descemet membrane	http://purl.obolibrary.org/obo/HP_0011490	Abnormal Descemet membrane morphology		The thickness of the Descement membrane is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000313	Incomplete right bundle branch block	http://purl.obolibrary.org/obo/HP_0011710	Bundle branch block		Right bundle branch block (RBBB) represents an abnormality in the intraventricular electrical conduction system of the human heart, generating enlarged QRS and modified vectors on the electrocardiogram (ECG). Incomplete RBBB (IRBBB) is defined by (i) QRS duration between 110 and 120 ms in adults; (ii) rsr, rsR, or rSR in leads V1 or V2. The R or r deflection is usually wider than the initial R wave. In a minority of patients, a wide and often notched R wave pattern may be seen in leads V1 and/or V2; (iii) S wave of greater duration than R wave or greater than 40 ms in leads I and V6 in adults; and (iv) Normal R peak time in leads V5 and V6 but greater than 50 ms in lead V1. The first 3 criteria should be present to make the diagnosis. When a pure dominant R wave with or without a notch is present in V1, criterion 4 should be satisfied.
http://purl.obolibrary.org/obo/HP_6000314	Perimenopausal onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		Onset of signs or symptoms of disease during the period of a woman's life shortly before the occurrence of the menopause.
http://purl.obolibrary.org/obo/HP_6000315	Postmenopausal onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		Onset of signs or symptoms of disease during the period of a woman's life after the occurrence of the menopause.
http://purl.obolibrary.org/obo/HP_6000316	Spastic monoplegia	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Spastic weakness found in only one upper or lower extremity.
http://purl.obolibrary.org/obo/HP_6000317	Mosaic attenuation pattern in lung	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Mosaic attenuation pattern in the lung is a term used to describe regions of differing pulmonary attenuation on CT imaging. It is a non-specific finding, although is associated with several conditions such as obstructive small airway disease, occlusive vascular disease (in which case is called mosaic perfusion pattern), pulmonary edema, and parenchymal diseases.
http://purl.obolibrary.org/obo/HP_6000318	Elevated aldosterone:renin ratio	http://purl.obolibrary.org/obo/HP_0000847	Abnormality of renin-angiotensin system		The ratio of aldosterone concentration to renin concentration is above the upper limit of normal. If aldosterone is expressed in ng/dl and plasma renin activity is expressed as ng/ml/hr, then values above 20 with aldosterone level above 15 are considered indicative of primary aldosteronism.
http://purl.obolibrary.org/obo/HP_6000319	Meteorism	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		An increase in the gas content inside the bowel associated with distension of the abdomen and hydroaeric noises. The most common symptom of meteorism is a bloated sensation. It may be associated with abdominal discomfort. Some individuals may also complain of a distended stomach and excessive belching and/or passage of flatus.
http://purl.obolibrary.org/obo/HP_6000320	Failure to elevate ammonia on ischemic exercise	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		Normal subjects display an increase in the concentration of ammonia in the blood following an ischemic exercise test. This term refers to an increase in ammonia that is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000321	Labile Hypertension	http://purl.obolibrary.org/obo/HP_0000822	Hypertension		Frequent fluctuations of blood pressure between normal and high levels, changing more dramatically than normal.
http://purl.obolibrary.org/obo/HP_6000322	Absent axon flare response after intradermal histamine injection	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		The axon reflex (also known as the flare response) is a response that is stimulated by peripheral nerves of the body that travels away from the nerve cell body and branches to stimulate target organs. In the human skin, there are three different phenomena mediated by axon reflex mechanism; flare, sweating and pilomotion. Stroking or intradermal injection of histamine or substance P into the human skin pro- duces widespread vasodilatation (flare) and plasma extravasation (wheal). This term refers to the failure of intradermal hista injection to elicit flare.
http://purl.obolibrary.org/obo/HP_6000323	Reduced sympathoneural responses to the cold pressor test	http://purl.obolibrary.org/obo/HP_0012332	Abnormal autonomic nervous system physiology		Response to the cold pressor test below the lower limit of normal. The cold pressor test is a simple and validated test in which the subject immerses one hand or foot into ice water for 1 to 3 minutes while blood pressure (BP) and heart rate are monitored. The cold stimulus activates afferent sensory pathways that, in turn, trigger a sympathetic response resulting in an increase in BP.
http://purl.obolibrary.org/obo/HP_6000324	Positive stool Giardia antigen test	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Fecal analysis for Giardia antigen is abnormal. Tests include direct fluorescent-antibody (DFA), which detects intact organisms, and enzyme immunoassays (EIAs), which detect soluble stool antigens.
http://purl.obolibrary.org/obo/HP_6000325	Excessive blood loss during delivery	http://purl.obolibrary.org/obo/HP_0032467	Past obstetric history		Loss of a substantial amount of blood during delivery (some definitions stipulate 1000 ml or more), typically associated with manifestations such as low blood pressure, a rapid heart rate, dizziness, light-headedness, fatigue, and weakness.
http://purl.obolibrary.org/obo/HP_6000326	Cardiac valve vegetations	http://purl.obolibrary.org/obo/HP_0001654	Abnormal heart valve morphology		Endocarditis infection occurs along the edges of the heart valves. Damage to the cardiac endothelium followed by platelet and fibrin deposition results in a sterile lesion known as nonbacterial thrombotic endocarditis (NBTE) or vegetation. Microbes entering the bloodstream via routine or invasive procedures adhere to the vegetation and are engulfed in an outer meshwork of fibrin and platelets. Subsequent rapid microbial multiplication in a protected area of impaired host defense leads to vegetation growth and continuous bacteremia.
http://purl.obolibrary.org/obo/HP_6000327	Thoracic cage flatness	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		The anteroposterior dimension of the chest on the lateral radiograph is often relatively narrow compared with the chest width on the frontal radiograph.
http://purl.obolibrary.org/obo/HP_6000328	Absent zona pellucida	http://purl.obolibrary.org/obo/HP_0020156	Abnormal zona pellucida morphology		Lack of the oocyte extracellular matrix region (zona pellucida). This feature can be observed following follicular aspiration (retrieval of eggs for fertility treatments).
http://purl.obolibrary.org/obo/HP_6000329	Umbilical cord prolapse	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		The presence of the umbilical cord (UC) between the fetal presenting part and the cervix, regardless of the membrane status (intact or ruptured). Descent of the UC through the cervix is essential for diagnosing cord prolapse. It can be either overt (past the presenting part) or occult (alongside the presenting part).
http://purl.obolibrary.org/obo/HP_6000330	Increased ratio of deoxypyridinoline to pyridinoline cross-links in urine	http://purl.obolibrary.org/obo/HP_0033384	Elevated urinary collagen degradation products		The relative concentration of deoxypyridinoline (Dpyr) to that of pyridinoline (Pyr) cross-links in urine is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000331	Elevated urinary thymine level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		The amount of thymine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000332	Elevated urinary indoleacetic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of indoleacetic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000333	Reduced hepatic phosphorylase kinase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of phosphorylase kinase in liver tissue below the lower limit of normal. Phosphorylase kinase (PhK) has a major regulatory role in the breakdown of glycogen. The enzyme PhK comprises four copies each of four subunits, encoded by PHKA1, PHKA2, PHKB, and PHKG.
http://purl.obolibrary.org/obo/HP_6000334	Reduced hepatic ornithine transcarbamylase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity or concentration of ornithine transcarbamylase in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000335	Elevated urinary quinolinic acid level	http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level		The amount of quinolinic acid in the urine, normalized for urine concentration, is above the upper limit of normal. Quinolinic acids is a pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
http://purl.obolibrary.org/obo/HP_6000336	Rectal duplication	http://purl.obolibrary.org/obo/HP_0002034	Abnormal rectum morphology		A developmental anomaly characterized by an additional rectum that is typically lined with intestinal mucosa with one or more cell types of the gastrointestinal tract overlying submucosa and smooth muscle layer.
http://purl.obolibrary.org/obo/HP_6000337	Thinned small intestinal mucosa	http://purl.obolibrary.org/obo/HP_0025129	Abnormal small intestinal mucosa morphology		Abrnormal reduction in the height of the mucosa of the small intestine. The mucosa is arranged in regular circular folds (the circular valves of Kerckrin), the mucosal surface is covered with small projections called villi, which are slender, about 1.5-2 mm long projections of the mucosa into the lumen. In between the villi are the crypts. This term refers to a pathological thinning of these structures.
http://purl.obolibrary.org/obo/HP_6000338	Seminal vesicle hypoplasia	http://purl.obolibrary.org/obo/HP_6000190	Abnormal seminal vesicle morphology		A congenital anomaly characterized by underdevelopment of one or both seminal vesicles, which are the two small glands that store and produce the majority of the fluid that makes up semen.
http://purl.obolibrary.org/obo/HP_6000339	Decreased fetal abdominal circumference	http://purl.obolibrary.org/obo/HP_0020303	Abnormal fetal abdominal circumference		The distance around the abdomen of a fetus, generally as measured by prenatal sonography, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000340	Prenatal flattened diaphragm	http://purl.obolibrary.org/obo/HP_0034243	Abnormal fetal pulmonary morphology		The diaphragm normally projects up into the thoracic cavity. In the presence of malformations such as enlarged lungs, the diaphragm may appear abnormally flat or even everted (with the middle of the diaphragm projecting downwards into the abdominal cavity).
http://purl.obolibrary.org/obo/HP_6000341	Snowflake effect in amniotic cavity	http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid		Dense floating particles in amniotic fluid, said to resemble snowflakes. This finding can result from shedding of the epidermis in conditions such as Harlequin ichthyosis.
http://purl.obolibrary.org/obo/HP_6000342	Thickened mitral valve cusp	http://purl.obolibrary.org/obo/HP_0031480	Abnormal mitral valve leaflet morphology		An abnormally increased thickness of a leaflet of the mitral valve.
http://purl.obolibrary.org/obo/HP_6000343	Antiparietal cell antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against parietal cell antigens.
http://purl.obolibrary.org/obo/HP_6000344	Anti-intrinsic factor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against intrinsic factor.
http://purl.obolibrary.org/obo/HP_6000345	Anti-human immunodeficiency virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of the human immunodeficiency virus (HIV).
http://purl.obolibrary.org/obo/HP_6000346	Anti-polio virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of poliovirus.
http://purl.obolibrary.org/obo/HP_6000347	Anti-NR2A antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the N-Methyl-D-aspartate (NMDA) receptor NR2A subunit.
http://purl.obolibrary.org/obo/HP_6000348	Antistreptolysin O antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against streptolysin O.
http://purl.obolibrary.org/obo/HP_6000349	Reduced tissue tissue AICAR transformylase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; EC 2.1.2.3) a in a tissue is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000350	Ameliorated by gastric acid-reducing therapy	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with an agent that reduces gastric acidity such as proton pump inhibitors, histamine receptor blockers,omeprazole, esomeprazole, dexlansoprazole, pantoprazole, lansoprazole, famotidine, or ranitidine.
http://purl.obolibrary.org/obo/HP_6000351	Anti-coagulation factor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of an antibody in the blood circulation that is directed against a coagulation factor.
http://purl.obolibrary.org/obo/HP_6000352	Tachyphagia	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		Excessively rapid eating of food.
http://purl.obolibrary.org/obo/HP_6000353	Reduced tissue argininosuccinate synthetase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration of argininosuccinate synthetase (EC 6.3.4.5) in body tissues is below the lower limit of normal. Clinically, argininosuccinate synthetase is measured in the liver or in cultered skin fibroblasts.
http://purl.obolibrary.org/obo/HP_6000354	Reduced aspartoacylase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of aspartoacylase below the lower limit of normal in cultured fibroblasts. Aspartoacylase (EC 3.5.1.15), also called aminoacylase-2, is an enzyme that hydrolyzes N-acetyl-L-aspartic acid (NAA) to aspartate and acetate.
http://purl.obolibrary.org/obo/HP_6000355	Reduced malonyl-CoA decarboxylase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of malonyl-CoA decarboxylase (EC 4.1.1.9) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000356	Reduced tissue medium-chain acyl-CoA dehydrogenase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of medium-chain acyl-CoA dehydrogenase (EC 1.3.8.7;MCAD) in tissues is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000357	Reduced cystathionine beta-synthase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of cystathionine beta-synthase (EC 4.2.1.22) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000358	Reduced muscle glycogen phosphorylase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the enzyme glycogen phosphorylase in muscle tissue is below the lower limit of normal. Glycogen phosphorylase (EC 2.4.1.1) is also known as amylophosphorylase, muscle phosphorylase a and b, polyphosphorylase, and myophosphorylase.
http://purl.obolibrary.org/obo/HP_6000359	Reduced muscle 6-phosphofructokinase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Activity of the enzyme 6-phosphofructokinase in muscle tissue is below the lower limit of normal. 6-phosphofructokinase (EC 2.7.1.11) is also known as phosphofructokinase I and phosphohexokinase. The PFKM gene encodes the muscle isoform of phosphofructokinase. PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis.
http://purl.obolibrary.org/obo/HP_6000360	Reduced tissue alpha-N-acetylglucosaminidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of alpha-N-acetylglucosaminidase (EC 3.2.1.50) below the lower limit of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts. It is also known as alpha-acetylglucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, and alpha-D-2-acetamido-2-deoxyglucosidase.
http://purl.obolibrary.org/obo/HP_6000361	Reduced succinyl-CoA:3-oxoacid-CoA transferase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of succinyl-CoA:3-oxoacid-CoA transferase (SCOT, or OXCT1; EC 2.8.3.5) below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000362	Blunted aldosterone response to aldosterone suppression test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		A non-suppressible aldosterone excess, defined as an abnormal result of one of any four suppression tests. These tests use oral sodium loading, oral fludrocortisone, oral captopril, or saline infusion to suppress aldosterone secretion.
http://purl.obolibrary.org/obo/HP_6000363	Flank mass	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		An abnormal enlargement or swelling in the flank, which is the fleshy part of the side of the body between the ribs and the hip.
http://purl.obolibrary.org/obo/HP_6000364	Synovial cyst	http://purl.obolibrary.org/obo/HP_0025850	Abnormal synovial cavity morphology		A fluid-filled sac or pouch-like mass that is a distention of a preexisting bursa in a joint, tendon sheaths or bursae. Synovial cysts contain synovial fluid and are lined by synovial membrane.
http://purl.obolibrary.org/obo/HP_6000365	Brown pigmentation of the conjunctiva	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Deposition of brown pigmentation in the conjunctiva.
http://purl.obolibrary.org/obo/HP_6000366	Gastrocnemius contracture	http://purl.obolibrary.org/obo/HP_0005750	Lower-limb joint contracture		Limitation of simultaneous ankle dorsiflexion and knee extension during mid-stance of gait.
http://purl.obolibrary.org/obo/HP_6000367	Central thinning of the outer nuclear layer of the retina	http://purl.obolibrary.org/obo/HP_0030329	Retinal thinning on OCT		Reduced thickness of the outer nuclear layer in the middle region of the retina. The outer nuclear layer (ONL) of the retina contains the nuclei of the cone and rod photoreceptors. Loss of the cellular machinery found in these nuclei causes irreparable loss of the photoreceptors and the capacity for visual function. This feature can be appreciated by directional optical coherence tomography.
http://purl.obolibrary.org/obo/HP_6000368	Sonographic renal salt and pepper pattern	http://purl.obolibrary.org/obo/HP_0033130	Abnormal renal echogenicity		Heterogeneous, increased parenchymal echogenicity. This imaging appearance is caused by multiple tiny cysts smaller than or just approaching the size necessary for detection, which disrupt the echo pattern without being clearly distinguishable, and appear as white grains on renal ultrasound, mainly in a subcapsular location.
http://purl.obolibrary.org/obo/HP_6000369	Ductus venosus agenesis with intrahepatic drainage	http://purl.obolibrary.org/obo/HP_0034196	Ductus venosus agenesis		A form of ductus venosus agenesis in which the umbilical vein connects via the portal sinus to the portal venous system (PVS) without giving rise to the ductus venosus. In some cases an intrahepatic shunt from a portal to a hepatic vein can be detected prenatally. This variant has been reported to have a favorable prognosis.
http://purl.obolibrary.org/obo/HP_6000370	Ductus venosus agenesis with extrahepatic drainage and liver bypass	http://purl.obolibrary.org/obo/HP_0034196	Ductus venosus agenesis		A form of ductus venosus agenesis in which umbilical vein does not connect to the portal venous system. The liver is bypassed and the umbilical vein drains into a systemic vein such as the inferior vena cava. This variant has been reported to have an unfavorable prognosis due to a presumed association with congestive heart failure and hydrops.
http://purl.obolibrary.org/obo/HP_6000371	Elevated circulating D-glyceric acid concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		The concentration of D-gyceric acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000372	Elevated CSF D-glyceric acid concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		The concentration of D-carboxylic acid in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000373	Ameliorated by riboflavin	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by ingestion of riboflavin (Vitamin B2).
http://purl.obolibrary.org/obo/HP_6000374	Increased circulating interleukin 1beta concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		An increased concentration of interleukin-1beta in the blood circulation.
http://purl.obolibrary.org/obo/HP_6000375	Reduced neutrophil myeloperoxidase activity	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		Concentration or activity of myeloperoxidase (EC 1.11.1.7) as measured in neutrophils is below the limits of normal.
http://purl.obolibrary.org/obo/HP_6000376	Jugular foramen stenosis	http://purl.obolibrary.org/obo/HP_0002693	Abnormal skull base morphology		Reduction in diameter of the jugular foramen, an opening in the base of the skull that is located behind the carotid canal and is formed by the temporal bone and the occipital bone. The inferior petrosal sinus, three cranial nerves, the sigmoid sinus, and meningeal arteries pass through the jugular foramen.
http://purl.obolibrary.org/obo/HP_6000377	Intramural intestinal gas	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		The presence of extraluminal gas within the bowel wall.
http://purl.obolibrary.org/obo/HP_6000378	Delayed scintigraphic gallbladder filling	http://purl.obolibrary.org/obo/HP_0012438	Abnormal gallbladder physiology		Hepatobiliary scintigraphy is a nuclear imaging technique that permits evaluation of the liver and biliary system for acute and chronic cholecystitis, biliary atresia, biliary obstruction, and post-surgical biliary leak. With this investigation, a radiotracer is administered intravenously, bound to albumin, transported to the liver, and excreted into the biliary system. This term refers to a longer than normal time for the radiotracer to be visualized in the gallbladder. This finding may be a sign of chronic gallbladder disease or partial obstruction of the common bile duct.
http://purl.obolibrary.org/obo/HP_6000379	Pancreatic arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Pancreatic arteriovenous malformation is defined as an abnormal vascular net, developed from one or more feeding arteries and enlarged early draining veins, creating an arteriovenous shunting.
http://purl.obolibrary.org/obo/HP_6000380	Anti-perilipin-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against perilipin-1 (PLIN1).
http://purl.obolibrary.org/obo/HP_6000381	Splenic calcification	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Calcification, that is, pathological deposition of calcium salts in the spleen.
http://purl.obolibrary.org/obo/HP_6000382	Short esophagus	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Abnormal reduction in the length of the esophagus.
http://purl.obolibrary.org/obo/HP_6000383	Gastric perforation	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		A full-thickness injury of the wall of the stomach.
http://purl.obolibrary.org/obo/HP_6000384	Gastric volvulus	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		A gastric volvulus occurs when the stomach rotates on itself at least 180 degrees along its transverse or longitudinal axis.
http://purl.obolibrary.org/obo/HP_6000385	Elevated circulating sCD163 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of sD163 (= soluble cluster of differentiation 163, = soluble CD163) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000386	Positive cold agglutinin test	http://purl.obolibrary.org/obo/HP_6000388	Anti-erythrocyte autoantibody positivity		Cold agglutinin are erythrocyte antibodies which possess the property of agglutinating red blood cells at temperatures of below 37 degrees C, this phenomenon is reversible after heating.
http://purl.obolibrary.org/obo/HP_6000387	Anti-D-L antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of Donath-Landsteiner (D-L) autoantibodies (immunoglobulins) in the serum.
http://purl.obolibrary.org/obo/HP_6000389	Non-glucose reducing substance in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		Abnormal result for this screening test for urinary reducing substances including glucose, fructose, galactose, lactose, pentose and maltose, as well as amino acids, cysteine, tyrosine, homogentisic acid, ketone bodies, ascorbic acid and many drugs. This term is applied if the urine stick test for glucose was negative (normal).
http://purl.obolibrary.org/obo/HP_6000390	Elevated urinary succinylaminoimidazole carboxamide riboside level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		Presence of succinylaminoimidazole carboxamide riboside (SAICAr). SAICAr is a toxic intermediate metabolite of purine synthesis.
http://purl.obolibrary.org/obo/HP_6000391	Elevated urine hyaluronic acid level	http://purl.obolibrary.org/obo/HP_0003541	Urinary glycosaminoglycan excretion		Excessive amount of hyaluronic acid in urine.
http://purl.obolibrary.org/obo/HP_6000392	Elevated urinary methylmalonylcarnitine level	http://purl.obolibrary.org/obo/HP_0500170	Abnormal concentration of acylcarnitine in the urine		The amount of methylmalonylcarnitine in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000393	Elevated urine trihydroxycholestanoic acid level	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		Presence of trihydroxycholestanoic acid in the urine. Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid. Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome.
http://purl.obolibrary.org/obo/HP_6000394	Elevated CSF ammonia concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of amonia in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000395	Positive CSF VDRL test	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		An abnormal (positive) result of the Venereal Disease Research Laboratory (VDRL) test performed in cerebrospinal fluid (CSF), suggesting past or present neurosyphilis.
http://purl.obolibrary.org/obo/HP_6000396	Elevated CSF guanidinoacetic acid concentration	http://purl.obolibrary.org/obo/HP_0020004	Abnormal CSF guanidinoacetic acid concentration		The concentration of guanidinoacetic acid in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000397	CSF oligoclonal immunoglobulin G bands	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Oligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a central humoral response. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent a hallmark of multiple sclerosis (MS).
http://purl.obolibrary.org/obo/HP_6000398	Decreased CSF 3-methoxy-4-hydroxyphenylglycolaldehyde concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of 3-methoxy-4-hydroxyphenylglycolaldehyde in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000399	Elevated CSF alpha-crystallin B chain concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		The concentration of alpha-crystallin B chain in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000400	Reduced CSF creatine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of creatine in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000401	Decreased circulating vitamin K-dependent protein Z concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of vitamin K-dependent protein Z in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000402	Elevated circulating 27-hydroxycholesterol concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		The concentration of 27-hydroxycholesterol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000403	Elevated circulating lysophosphatidylcholine concentration	http://purl.obolibrary.org/obo/HP_0040300	Abnormal circulating free fatty acid concentration		The concentration of lysophosphatidylcholines in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000404	Reduced circulating insulin-like growth factor 2 concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		The concentration of insulin-like growth factor 2 (IGF2) in the blood circulation is below the lower limit of normal. IGF2 is a peptide hormone regulating various cellular processes such as proliferation and apoptosis.
http://purl.obolibrary.org/obo/HP_6000405	Decreased circulating nicotinamide adenine dinucleotide concentration	http://purl.obolibrary.org/obo/HP_0004352	Abnormal circulating purines concentration		The concentration of nicotinamide adenine dinucleotide in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000406	Diminished circulating reduced nicotinamide adenine dinucleotide concentration	http://purl.obolibrary.org/obo/HP_0004352	Abnormal circulating purines concentration		The concentration of reduced nicotinamide adenine dinucleotide (NADH) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000407	Elevated circulating fibroblast growth factor 23 concentration	http://purl.obolibrary.org/obo/HP_6000489	Abnormal circulating fibroblast growth factor 23 concentration		The concentration of fibroblast growth factor 23 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000408	Reduced CSF asparagine concentration	http://purl.obolibrary.org/obo/HP_0500205	Abnormal CSF aspartate family amino acid concentration		The concentration of asparagine in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000409	Pancreatic mass	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		A swelling or enlargement localized to the pancreas. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000410	Small intestine mass	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		A swelling or enlargement localized to the small intestine. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000411	Facial nerve compression	http://purl.obolibrary.org/obo/HP_0001293	Cranial nerve compression		Impingement of another object such as a blood vessel upon the facial nerve, causing it to lose volume in the compressed region.
http://purl.obolibrary.org/obo/HP_6000412	Pulmonary perfusion defect	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		Lack of blood perfusion in a specific area of the lung. Pulmonary ventilation (V) and Perfusion (Q) scan, also known as lung V/Q scan, is a nuclear test that uses the perfusion scan to delineate the blood flow distribution and the ventilation scan to measure airflow distribution in the lungs.
http://purl.obolibrary.org/obo/HP_6000413	Ectopic ureteral orifice	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		Drainage of the ureter on one or both sides into an abnormal location. Normally the ureter drains via the internal ureteral orifice at the trigone of the urinary bladder. Ectopic ureteral orifice can be either intravesical (bladder neck) or, more often, extravesical. Ectopia in women is more frequently found in the urethra and the vaginal vestibule; much less frequently in vagina and in uterus. In men it is mostly found in the posterior urethra; in the male genital tract is very rare.
http://purl.obolibrary.org/obo/HP_6000414	Duplicate uterine cervix	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		A congenital developmental defect characterized by the presence of two cervices on the uterus.
http://purl.obolibrary.org/obo/HP_6000415	Intradural spinal lipoma	http://purl.obolibrary.org/obo/HP_6000590	Spinal lipoma		Intradural spinal lipoma (ISL) constitutes approximately 1% of all spinal tumors and is usually associated with lumbo-sacral spinal dysraphism. ISLs unassociated with spinal dysraphism are rare with only a few cases being reported in literature. They are seen in children and young adults and are situated on the posterior aspect of the spinal cord in the cervico-thoracic or thoracic regions. They represent intradural, subpial, juxtamedullary lesions.
http://purl.obolibrary.org/obo/HP_6000416	T2 hyperintense cerebellar lesion	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the cerebellum. This term refers to a localized hyperintensity affecting a particular region of the cerebellum.
http://purl.obolibrary.org/obo/HP_6000417	Inferior vena cava obstruction	http://purl.obolibrary.org/obo/HP_0025576	Abnormal inferior vena cava morphology		Physical invasion or compression of the inferior vena cava by a pathological process or by thrombosis within the vein itself.
http://purl.obolibrary.org/obo/HP_6000418	Rheumatoid nodule	http://purl.obolibrary.org/obo/HP_0001482	Subcutaneous nodule		A well-demarcated, flesh colored, subcutaneous and usually freely movable lump or mass. Rheumatoid nodules can vary in size from small, pea sized lesions up to the size of a lemon and are most often round. The nodules usually are doughy or firm however and not tender. Typically rheumatoid nodules are distributed over areas of repeated trauma or pressure and occur adjacent to joints on extensor surfaces, such as the elbow, fingers and forearms.
http://purl.obolibrary.org/obo/HP_6000419	Elevated circulating proinsulin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		The concentration of proinsulin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000420	Burning eye sensation	http://purl.obolibrary.org/obo/HP_0200026	Ocular pain		A feeling of stinging or irritation of the eyes.
http://purl.obolibrary.org/obo/HP_6000421	Collarettes	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Buildup of waxy flesh-colored scales on the margin of the eyelid.
http://purl.obolibrary.org/obo/HP_6000422	Tympanic membrane bulla	http://purl.obolibrary.org/obo/HP_0040090	Abnormal tympanic membrane morphology		Presence of blisters (bullae) on the tympanic membrane, often accompanied by fever, thickening, and erythematous appearance of the tympanic membrane, decreased or absent light reflex, and decreased mobility.
http://purl.obolibrary.org/obo/HP_6000423	Beard and mustache distribution	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality whose distribution and appearance are located at regions of the male face covered by a beard or mustache.
http://purl.obolibrary.org/obo/HP_6000424	Kerion	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Kerion is an erythematous, boggy, tender, often sterile, weeping nodule or plaque with pustules and draining sinuses. Hair in these areas appears lusterless, brittle, and is easily plucked. Kerion can be solitary or multiple but is usually unilateral. Patients with inflammatory tinea barbae may have constitutional symptoms like fever and malaise. Kerion is a coalesced sterile pustule, but occasionally they can get superinfected with cutaneous bacteria and develop regional lymphadenopathy.
http://purl.obolibrary.org/obo/HP_6000425	Truncal location	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in (or predominant in) the trunk of the body. The trunk is the main part of a person's body, not including the head, legs, or arms.
http://purl.obolibrary.org/obo/HP_6000426	Reduced Acyl-CoA:dihydroxyacetone phosphate acyltransferase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of acyl-CoA:dihydroxyacetone phosphate acyltransferase below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000427	Reduced alkyl-dihydroxyacetonephosphate synthase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of alkyl-dihydroxyacetonephosphate (DHAP) synthase below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000428	Glomerular fibronectin deposits	http://purl.obolibrary.org/obo/HP_0030949	Glomerular deposits		Accumulation of fibronectin in the glomerulus.
http://purl.obolibrary.org/obo/HP_6000429	Renal tubular karyomegaly	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Marked enlargement of nuclei observed predominantly in the proximal convoluted tubule cells.
http://purl.obolibrary.org/obo/HP_6000430	Reduced tissue acetyl-CoA carboxylase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of acetyl-CoA carboxylase in the tissues below the lower limit of normal. The activity can be measured in multiple tissues including liver.
http://purl.obolibrary.org/obo/HP_6000431	Elevated urinary glycolic acid level	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		The amount of glycolic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000432	Elevated urine propionic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		The amount of propionic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000433	Elevated urinary butyric acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of butyric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000434	Elevated urinary isovaleric acid level	http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria		The amount of isovaleric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000435	Elevated circulating alpha-ketoglutarate concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		The concentration of alpha-ketoglutarate in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000436	Elevated circulating ghrelin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		The concentration of ghrelin in the blood circulation is above the upper limit of normal. Ghrelin is a 28-amino-acid peptide predominantly secreted in the stomach and stimulates appetite and growth hormone (GH) release.
http://purl.obolibrary.org/obo/HP_6000437	Decreased circulating stearoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033445	Reduced circulating acylcarnitine concentration		The concentration of stearoylcarnitine (C18:0) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000438	Reduced urinary iodine level	http://purl.obolibrary.org/obo/HP_0025640	Abnormal urinary mineral level		The amount of iodine in the urine, normalized for urine concentration, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000439	Increased circulating interleukin 15 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		The concentration of interleukin 15 (IL-15) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000440	Reduced circulating squalene concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		The concentration of squalene in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000441	Abnormal circulating interleukin 6 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 6 (IL-6) in the blood circulation.
http://purl.obolibrary.org/obo/HP_6000442	Abnormal circulating interleukin 12 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		Any deviation from the normal range of the concentration of interleukin 12 in the blood circulation.
http://purl.obolibrary.org/obo/HP_6000443	Elevated blood mercury concentration	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		The concentration of mercury in the blood is above the upper limit of a guidance value for total blood mercury concentrations that implies possible injurious effects.
http://purl.obolibrary.org/obo/HP_6000444	Elevated blood cadmiun concentration	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		The concentration of cadmium in the blood is above the upper limit of a guidance value for total blood mercury concentrations that implies possible injurious effects.
http://purl.obolibrary.org/obo/HP_6000445	Elevated thallium concentration	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		The concentration of thallium in the blood is above the upper limit of a guidance value for total blood mercury concentrations that implies possible injurious effects.
http://purl.obolibrary.org/obo/HP_6000446	Abnormal circulating CC chemokine concentration	http://purl.obolibrary.org/obo/HP_0011115	Abnormal circulating chemokine concentration		The concentration in the blood circulation of a member of the CC chemokine family is outside of normal limits.
http://purl.obolibrary.org/obo/HP_6000447	Decreased CSF asialotransferrin to transferrin ratio	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		The concentration of asialotransferrin relative to that of transferrin in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000448	Anti-desmocollin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against desmocollin.
http://purl.obolibrary.org/obo/PATO_0010007	multiciliated	http://purl.obolibrary.org/obo/PATO_0001408	ciliated		A cellular quality inhering in a bearer by virtue of the bearer's having multiple cilia.
http://purl.obolibrary.org/obo/HP_0025840	Abnormal HLA-DR+ CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_5200023	Abnormal HLA-DR+ T cell proportion		Abnormal increase or decrease of the activated HLA-DR+ CD4+ T cell subpopulation, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_6001203	Snapping sensation at time of injury	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		A popping or snapping sensation (noise or feeling) at the time of an injury.
http://purl.obolibrary.org/obo/HP_6001204	Pagetoid spread	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Pagetoid spread connotes the spread of single neoplastic cells, and small nests of them above the basal layer in a variety of melanocytic and nonmelanocytic neoplasms similar to the pattern seen in Paget's and in extramammary Paget disease.
http://purl.obolibrary.org/obo/HP_6001205	Central scarring	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Central scarring of skin lesions.
http://purl.obolibrary.org/obo/HP_6001206	Scapholunate ligament tear	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		A breakage (partial or complete tear) of the scapholunate ligament. The most common cause is physical trauma to the wrist such as a fall onto an outstretched hand. Tear of the scapholunate ligament may lead to carpal instability.
http://purl.obolibrary.org/obo/HP_6001207	Lunotriquetral ligament tear	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		A breakage (partial or complete tear) of the lunotriquetral ligament. The most common cause is physical trauma to the wrist such as a fall onto an outstretched hand. Rupture or tear of the the lunotriquetral ligament may lead to carpal instability.
http://purl.obolibrary.org/obo/HP_6001208	Pisotriquetral arthritis	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		Arthritis at the pisotriquetral joint. Radiographic evidence of arthritis at the pisotriquetral joint includes joint space narrowing, osteophytes, subchondral cysts, and/or subchondral sclerosis.
http://purl.obolibrary.org/obo/HP_6001209	Volar intercalated segment instability	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		A type of carpal instability characterized by volar tilt of the lunate bone.
http://purl.obolibrary.org/obo/HP_6001210	Inaccurate finger pulse oximetry oxygen saturation measurement	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Any substantial discrepancy between the measurement of oxygen saturation with finger probe pulse oximetry as compared to an arterial blood gas, which is considered the gold standard.
http://purl.obolibrary.org/obo/HP_6001211	Finger pulse oximetry lower than arterial blood gas analysis measurement of oxygen saturation	http://purl.obolibrary.org/obo/HP_6001210	Inaccurate finger pulse oximetry oxygen saturation measurement		Inaccurately reduced oxygen saturation as measured by finger or toe pulse oximetry compared to oxygen saturation as measured by venous or arterial blood gas analysis.
http://purl.obolibrary.org/obo/HP_6001212	Finger pulse oximetry higher than arterial blood gas analysis measurement of oxygen saturation	http://purl.obolibrary.org/obo/HP_6001210	Inaccurate finger pulse oximetry oxygen saturation measurement		Inaccurately elevated oxygen saturation as measured by finger or toe pulse oximetry compared to oxygen saturation as measured by venous or arterial blood gas analysis.
http://purl.obolibrary.org/obo/HP_6001213	History of thumb sucking past the age of four years	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Thumb sucking is a behavior that ceases spontaneously in most children between 2 and 4 years of age. If thumb sucking continues, negative consequences can occur, such as a deformity of the nail or paronychia. This term refers to a history of habitual thumb sucking past the age of 4 years of life.
http://purl.obolibrary.org/obo/HP_6001214	Cutaneous granulomatosis	http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis		Skin inflammatory reaction triggered by a wide variety of stimuli, including infections, foreign bodies, malignancy, metabolites, and chemicals. From a pathogenic point of view, they are divided into non-infectious and infectious granulomas. From a clinical point of view, it is useful to divide cutaneous granulomatosis into localized and more disseminated forms, although this distinction can be sometimes artificial.
http://purl.obolibrary.org/obo/HP_6001215	Ureteric stricture	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		Obstruction of urine flow through one or both ureters caused by issues such as injury, infection, tumours and surgery.
http://purl.obolibrary.org/obo/HP_6001216	Arteriovenous crossing sign	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		A retinal vascular abnormality characterized by indentation or compression of a retinal vein at an arteriovenous crossing, leading to changes in venous caliber. AV crossing signs are commonly associated with hypertensive retinopathy and may contribute to retinal vein occlusion. They are indicative of vascular remodeling due to chronic hypertension or other systemic vascular diseases.
http://purl.obolibrary.org/obo/HP_6001217	Haab striae	http://purl.obolibrary.org/obo/HP_0011490	Abnormal Descemet membrane morphology		Curvilinear or circumferential breaks in Descemet membrane, typically associated with congenital glaucoma. Haab striae result from elevated intraocular pressure during corneal development, leading to the formation of horizontal or arcuate lines that may be visible on slit-lamp examination. They can contribute to corneal astigmatism and visual impairment.
http://purl.obolibrary.org/obo/HP_6001218	Positive Legionella sputum culture	http://purl.obolibrary.org/obo/HP_0430107	Sputum infectious agent		Growth of Legionella bacteria in a sputum culture.
http://purl.obolibrary.org/obo/HP_6001219	Positive Streptococcus pneumoniae sputum culture	http://purl.obolibrary.org/obo/HP_0430107	Sputum infectious agent		Streptococcus pneumoniae growth in sputum culture.
http://purl.obolibrary.org/obo/HP_6001220	Positive Blastomyces dermatitidis sputum fungal stain	http://purl.obolibrary.org/obo/HP_0430107	Sputum infectious agent		Demonstration of Blastomyces dermatitidis by microscopic examination of a stained sputum specimen.
http://purl.obolibrary.org/obo/HP_6001221	Posterior shoulder pain	http://purl.obolibrary.org/obo/HP_0030834	Shoulder pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the posterior (back) part of the shoulder.
http://purl.obolibrary.org/obo/HP_6001222	Superior shoulder pain	http://purl.obolibrary.org/obo/HP_0030834	Shoulder pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the superior or proximal aspect of the shoulder over the acromion, distal clavicle, and/or acromioclavicular (AC) joint.
http://purl.obolibrary.org/obo/HP_6001223	Lateral shoulder pain	http://purl.obolibrary.org/obo/HP_0030834	Shoulder pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the localized aspect (on the side) of the shoulder.
http://purl.obolibrary.org/obo/HP_6001224	Shoulder instability	http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology		Subjective or objective feeling of clunking/clicking in the shoulder with movement, shoulder 'giving way', or sensation of shoulder dislocating.
http://purl.obolibrary.org/obo/HP_6001225	Shoulder labrum tear	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		A injury with a team (rip, split, or disruption) to the labrum, which is the ring of cartilage that surrounds the socket of the shoulder joint (the glenoid).
http://purl.obolibrary.org/obo/HP_6001226	Positive modified dynamic labral shear test	http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology		Sensation of a pain with or without clicking or clunking sensation with the following test. Flex patients elbow to 90 degrees and abduct the arm 120 degrees while maximally externally rotating the arm, then examiner lowers the arm to 60 degrees of abduction. A positive test occurs with pain and/or a painful click along the posterior joint line between 120 degrees and 90 degrees of abduction.
http://purl.obolibrary.org/obo/HP_6001227	Positive O'Brien active compression test	http://purl.obolibrary.org/obo/HP_0025823	Positive provocative functional shoulder test		Pain in shoulder reproduced when examiner applies downward pressure on the arm while patient resists pressure in the following position: elbow extended, shoulder forward flexed to 90 degrees and 10-15 degrees adducted with palm facing down. This can be compared to the same position but with the palm facing up which should be less painful.
http://purl.obolibrary.org/obo/HP_6001228	Positive shoulder apprehension test	http://purl.obolibrary.org/obo/HP_0025823	Positive provocative functional shoulder test		The individual being investigated displays noticeable apprehension (unease) during a test for shoulder instability in which the individual is laying supine with shoulder abducted to 90 degrees, elbow flexed to 90 degrees, and an external rotation pressure with combined downward pressure is applied on the upper arm.
http://purl.obolibrary.org/obo/HP_6001229	Foamy tear film	http://purl.obolibrary.org/obo/HP_0000632	Lacrimation abnormality		A condition characterized by the presence of foam or bubbles within the tear film, often associated with meibomian gland dysfunction or ocular surface diseases.
http://purl.obolibrary.org/obo/HP_6001230	Salzmann corneal nodules	http://purl.obolibrary.org/obo/HP_0007705	Corneal degeneration		The formation of large, bluish, nodular lesions in the superficial corneal stroma, often associated with chronic keratitis or aging. These nodules may lead to visual impairment.
http://purl.obolibrary.org/obo/HP_6001231	Corneal stromal vascularisation	http://purl.obolibrary.org/obo/HP_0011496	Corneal neovascularization		The abnormal growth of blood vessels into the corneal stroma, often associated with ocular herpes, chronic inflammation, infection, or hypoxia. This condition can lead to corneal scarring and vision impairment.
http://purl.obolibrary.org/obo/HP_6001232	Corneal iron line	http://purl.obolibrary.org/obo/HP_0011495	Abnormal corneal epithelium morphology		Linear or arcuate deposition of iron within the corneal epithelium or stroma, typically associated with conditions such as keratoconus, corneal degeneration, or postsurgical corneal changes.
http://purl.obolibrary.org/obo/HP_6001233	Conjunctivochalasis	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		A condition characterized by redundant, loose conjunctival tissue, typically located between the globe and the lower eyelid, which may cause ocular discomfort, tear film instability, or epiphora.
http://purl.obolibrary.org/obo/HP_6001234	Conjunctival hyperpigmentation	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Increased pigmentation of the conjunctiva, characterized by brown or black discoloration due to melanocytic proliferation or pigment deposition. It may be associated with benign conditions such as primary acquired melanosis or malignant transformation into conjunctival melanoma.
http://purl.obolibrary.org/obo/HP_6001235	Anti-Saccharomyces cerevisiae antibodies	http://purl.obolibrary.org/obo/HP_0430076	Bloodstream antifungal antibody positivity		Antibodies against antigens presented by the cell wall of the yeast Saccharomyces cerevisiae.
http://purl.obolibrary.org/obo/HP_6001236	Elevated fraction exhaled nitric oxide	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		The fractional exhaled nitric oxide (FeNO) is elevated above the upper limit of normal. FeNO is an endogenous gaseous molecule which can be measured in the human breath test because of airway inflammation. It has been studied extensively as a marker of inflammation and has been incorporated into an algorithm for asthma management.
http://purl.obolibrary.org/obo/HP_6001237	Iris hyperemia	http://purl.obolibrary.org/obo/HP_0007905	Abnormal iris vasculature		A condition characterized by increased blood flow and congestion of the iris vasculature, leading to a reddish discoloration of the iris. Iris hyperemia is commonly associated with anterior uveitis, angle-closure glaucoma, or ocular inflammation.
http://purl.obolibrary.org/obo/HP_6001238	Elevated circulating reticulated platelet count	http://purl.obolibrary.org/obo/HP_0011873	Abnormal platelet count		The number of reticulated platelets per volume of blood in the peripheral circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001239	Reduced circulating reticulated platelet count	http://purl.obolibrary.org/obo/HP_0011873	Abnormal platelet count		The number of reticulated platelets per volume of blood in the peripheral circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001240	Abnormal circulating reticulated platelet count	http://purl.obolibrary.org/obo/HP_0011873	Abnormal platelet count		The number of reticulated platelets per volume of blood in the peripheral circulation is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_6001241	Flexed posturing of finger	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		A sign that can be observed in diseases such as Pyogenic or suppurative flexor tenosynovitis in which the affected finger is held in a flexed position. Often, there is pain on any attempt at passive finger extension. This finding is to be distinguished from a contracture of a finger joint in which the flexed positions is fixed.
http://purl.obolibrary.org/obo/HP_6001242	Positive synovial fluid alpha-defensin	http://purl.obolibrary.org/obo/HP_6000581	Positive synonvial fluid infectious agent test		Elevation of the the alpha-defensin concentration in synovial aspirate is above the upper limit of normal. The alpha-defensin test is a qualitative immunoassay optimized and validated for synovial fluid. The alpha-defensin protein is an antimicrobial peptide that is naturally released by neutrophils responding to a pathogen in the synovial fluid.
http://purl.obolibrary.org/obo/HP_6001243	Physeal fracture	http://purl.obolibrary.org/obo/HP_4000042	Fracture type		Salter-Harris fractures (physeal fractures) refer to fractures through a growth plate (physis) and are, therefore, specifically applied to bone fractures in children.
http://purl.obolibrary.org/obo/HP_6001244	Salter I fracture	http://purl.obolibrary.org/obo/HP_6001243	Physeal fracture		A type of physeal (Salter-Harris) fracture in which the fracture line extends through the physis or within the growth plate. Type I fractures are due to the longitudinal force applied through the physis, which splits the epiphysis from the metaphysis.
http://purl.obolibrary.org/obo/HP_6001245	Salter II fracture	http://purl.obolibrary.org/obo/HP_6001243	Physeal fracture		A type of physeal (Salter-Harris) fracture in which the fracture extends through both the physis and metaphysis. These are most common and occur away from the joint space. When the small corner of the metaphysis is visible, this is known as a corner sign or Thurston-Holland fragment.
http://purl.obolibrary.org/obo/HP_6001246	Salter III fracture	http://purl.obolibrary.org/obo/HP_6001243	Physeal fracture		A type of physeal (Salter-Harris) fracture in which the fracture is intra-articular and extends from the physis into the epiphysis.
http://purl.obolibrary.org/obo/HP_6001247	Salter IV fracture	http://purl.obolibrary.org/obo/HP_6001243	Physeal fracture		A type of physeal (Salter-Harris) fracture in which the fracture is intra-articular and passes through the epiphysis, physis, and metaphysis.
http://purl.obolibrary.org/obo/HP_6001248	Salter V fracture	http://purl.obolibrary.org/obo/HP_6001243	Physeal fracture		A type of physeal (Salter-Harris) fracture that is due to a crush or compression injury of the growth plate. In type V, the force is transmitted through the epiphysis and physis, potentially disrupting the germinal matrix, hypertrophic region, and vascular supply.
http://purl.obolibrary.org/obo/HP_6001249	Nail bed laceration	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		A cut or injury to the soft tissue under the fingernail or toenail.
http://purl.obolibrary.org/obo/HP_6001250	History of distal radius fracture	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Recent or remote history of distal radius fracture of the symptomatic arm.
http://purl.obolibrary.org/obo/HP_6001251	History of triangular fibrocartilage complex tear	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Recent or remote history of a tear in the triangular fibrocartilage complex (TFCC). The TFCC is a load-bearing structure between the lunate, triquetrum, and ulnar head. The function of the TFCC is to act as a stabilizer for the ulnar aspect of the wrist. The TFCC is at risk for either acute or chronic degenerative injury.
http://purl.obolibrary.org/obo/HP_6001252	Reduced plantar creases	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		The creases (wrinkles) on the soles of the feet are less pronounced than normal, or absent.
http://purl.obolibrary.org/obo/HP_6001253	Skin burn	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Damage to the skin and underlying tissues caused by an agents such as heat, chemicals, electricity, radiation, or friction, resulting in pain, redness, swelling, and sometimes blisters or charring.
http://purl.obolibrary.org/obo/HP_6001254	Elevanted carboxysterol concentration in cultured lymphoblasts	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		The concentration of carboxysterols in lymphoblastoid cells cultured in cholesterol-depleted medium is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001255	Superficial CNS hemosiderin deposition	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		An anomaly that can be ascertained by iron-specific magnetic resonance imaging (MRI) sequences such as gradient-echo (GRE) and susceptibility-weighted imaging (SWI). Superficial siderosis of the central nervous system is a chronic condition due to persistent or repeated long-term bleeding into the subarachnoid space, leading to subpial hemosiderin deposition. Hemosiderin deposition on MRI is seen as a T2 hypointensity and preferentially outlines the cerebellum and brainstem surface.
http://purl.obolibrary.org/obo/HP_6001256	Cortical superficial CNS hemosiderin deposition	http://purl.obolibrary.org/obo/HP_6001255	Superficial CNS hemosiderin deposition		A type of superficial CNS hemosiderin deposition that most commonly occurs due to iron deposits in the superficial cortical layers following bleeding from leptomeningeal vessels, most often from cerebral amyloid angiopathy in patients aged 55 or older.
http://purl.obolibrary.org/obo/HP_6001257	Infratentorial superficial CNS hemosiderin deposition	http://purl.obolibrary.org/obo/HP_6001255	Superficial CNS hemosiderin deposition		A type of superficial CNS hemosiderin deposition that involves the cerebellum and brainstem, most commonly the superior vermis, quadrigeminal plate, and basal cerebral surfaces. Cerebellar atrophy, particularly the superior vermis and anterior cerebellar hemispheres, can also be seen on a computed tomography scan of the head. The MRI of the spinal cord may reveal myelomalacia, syringomyelia, owl-eyes, or snake-eyes signs. The most common etiology for classic or primary infratentorial superficial siderosis is spinal dural defects, often dural tears.
http://purl.obolibrary.org/obo/HP_6001258	Pulmonary hyperplasia	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		Pulmonary Hyperplasia is an absolute increase in the number of alveoli, which are mildly enlarged. Pulmonary hyperplasia has been also referred to as polyalveolar lobe and type 3 cystic adenomatoid malformation.
http://purl.obolibrary.org/obo/HP_6001259	Positive protozoan parasite CSF wet mount test	http://purl.obolibrary.org/obo/HP_0430123	Positive CSF infectious agent test		Demonstration of protozoan parasites in a cerebrospinal fluid (CSF) specimen by microscopy.
http://purl.obolibrary.org/obo/HP_6001260	Gallbladder polyp	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		A gallbladder (GB) polyp is a growth that projects from the lining of the inside wall of the gallbladder into the lumen of the GB. GB polyps are a common incidental sonographic finding, the vast majority of which are benign.
http://purl.obolibrary.org/obo/HP_6001261	Gallbladder polyposis	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Multiple polyps arising from the gallbladder mucosal wall.
http://purl.obolibrary.org/obo/HP_6001262	Biceps tendon rupture	http://purl.obolibrary.org/obo/HP_0100550	Tendon rupture		Discontinuity of the biceps tendon as observed by ultrasound or magnetic resonance (MR) imaging.
http://purl.obolibrary.org/obo/HP_6001263	Medial epicondyle apophysitis	http://purl.obolibrary.org/obo/HP_6001435	Abnormal medial epicondyle morphology		Medial epicondyle apophysitis (MEA), also known as little league elbow, is an overuse injury prevalent among adolescent athletes whose sport involves repetitive overhand throwing, racket use, or other overhead arm motions. The medial epicondyle is a bony protrusion on the medial elbow with its own ossification center, separate from the main distal humeral physis, known as an apophysis. Medial epicondyle apophysitis occurs due to excessive and repetitive valgus stress placed on the apophysis before its closure. Over time, the repetitive strain results in a traction-type injury and may cause pathologic widening and inflammation of the apophysis or even an avulsion fracture.
http://purl.obolibrary.org/obo/HP_6001264	Thumb carpometacarpal subluxation	http://purl.obolibrary.org/obo/HP_0001172	Abnormal thumb morphology		A partial (subluxation) loss of alignment at the base of the thumb, where the first metacarpal bone meets the trapezium bone of the wrist. Thumb radiographs showing carpometacarpal (CMC) joint space widening and/or incongruity of the joint space between thumb metacarpal bone and the trapezium bone.
http://purl.obolibrary.org/obo/HP_6001265	Localized to lower eyelid	http://purl.obolibrary.org/obo/HP_6001266	Localized to eyelid		A descriptor indicating that a condition, lesion, or abnormality is confined to the lower eyelid. This localization may be relevant for various ocular conditions, including infections, structural abnormalities, or dermatological diseases affecting the lower eyelid region.
http://purl.obolibrary.org/obo/HP_6001266	Localized to eyelid	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in an eyelid.
http://purl.obolibrary.org/obo/HP_6001267	Halo vision	http://purl.obolibrary.org/obo/HP_0000505	Visual impairment		A visual phenomenon characterized by the perception of bright rings or halos surrounding light sources. Halo vision is often associated with optical irregularities such as corneal edema, cataracts, or intraocular lens complications. It may also occur in conditions affecting the tear film or due to the presence of glare from light scattering within the ocular media.
http://purl.obolibrary.org/obo/HP_6001268	Hematospermia	http://purl.obolibrary.org/obo/HP_0012874	Abnormal male reproductive system physiology		The presence of blood in the seminal fluid.
http://purl.obolibrary.org/obo/HP_6001269	Choledocholithiasis	http://purl.obolibrary.org/obo/HP_0035013	Abnormal extrahepatic bile duct morphology		Choledocholithiasis is the presence of stones within the common bile duct.
http://purl.obolibrary.org/obo/HP_6001270	Axillary nerve distribution	http://purl.obolibrary.org/obo/HP_0025849	Localized along nerve distribution		Paresthesias on the lateral aspect of the shoulder and upper arm. Weakness in shoulder abduction (deltoid) and shoulder external rotation (teres minor).
http://purl.obolibrary.org/obo/HP_6001271	Pelvic ring fracture	http://purl.obolibrary.org/obo/HP_0041161	Pelvis fracture		X-ray of the pelvis (AP, inlet, and outlet views) showing fracture of the pelvic ring, including iliac wing (ilium), superior or inferior pubic ramus, or ischium, and/or displacement of the pubic symphysis or sacroiliac joints.
http://purl.obolibrary.org/obo/HP_6001272	Scapulothoracic dissociation	http://purl.obolibrary.org/obo/HP_0000782	Abnormal scapula morphology		An injury consisting of a laterally displaced scapula with separation of the ipsilateral acromioclavicular joint, disruption of the ipsilateral subclavian vessels and brachial plexus, and an intact overlying skin.
http://purl.obolibrary.org/obo/HP_6001273	Pain exacerbated by weight bearing	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Refers to pain that is worse when the individual bears weight with the affected body part.
http://purl.obolibrary.org/obo/HP_0012756	CSF polymorphonuclear pleocytosis	http://purl.obolibrary.org/obo/HP_0012229	CSF pleocytosis		An increased polymorphonuclear cell count in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness	http://purl.obolibrary.org/obo/HP_0025732	Abnormal social development		A reduced ability to participate in the back-and-forth flow of social interaction appropriate to culture and developmental level, which is normally characterized by an influence of the behavior of one person on the behavior of another person. This results in difficulty interacting with others through emotional, physical, or verbal communication.
http://purl.obolibrary.org/obo/HP_0012761	Absent mastoid	http://purl.obolibrary.org/obo/HP_0000264	Abnormal mastoid morphology		A developmental anomaly in which the mastoid process fails to form and is thus found to be congenitally absent.
http://purl.obolibrary.org/obo/HP_0012763	Paroxysmal dyspnea	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		A sudden attack of dyspnea that occurs while the affected person is at rest.
http://purl.obolibrary.org/obo/HP_0012764	Orthopnea	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		A sensation of breathlessness in the recumbent position, relieved by sitting or standing.
http://purl.obolibrary.org/obo/HP_0012765	Widened cerebellar subarachnoid space	http://purl.obolibrary.org/obo/HP_0012704	Widened subarachnoid space		An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebellum.
http://purl.obolibrary.org/obo/HP_0012766	Widened cerebral subarachnoid space	http://purl.obolibrary.org/obo/HP_0012704	Widened subarachnoid space		An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebrum.
http://purl.obolibrary.org/obo/HP_0012768	Neonatal asphyxia	http://purl.obolibrary.org/obo/HP_0002643	Neonatal respiratory distress		Respiratory failure in the newborn.
http://purl.obolibrary.org/obo/HP_0012769	Abnormal arm span	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		A deviation from normal of the length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)
http://purl.obolibrary.org/obo/HP_0012770	Reduced arm span	http://purl.obolibrary.org/obo/HP_0012769	Abnormal arm span		Decreased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle).
http://purl.obolibrary.org/obo/HP_0012771	Increased arm span	http://purl.obolibrary.org/obo/HP_0012769	Abnormal arm span		Increased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle).
http://purl.obolibrary.org/obo/HP_0012772	Abnormal upper to lower segment ratio	http://purl.obolibrary.org/obo/HP_0000002	Abnormality of body height		A deviation from normal of the relation between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis.
http://purl.obolibrary.org/obo/HP_0012773	Reduced upper to lower segment ratio	http://purl.obolibrary.org/obo/HP_0012772	Abnormal upper to lower segment ratio		Decreased ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis. Consider the term Disproportionate tall stature (HP:0001519) if tall stature is also present.
http://purl.obolibrary.org/obo/HP_0012774	Increased upper to lower segment ratio	http://purl.obolibrary.org/obo/HP_0012772	Abnormal upper to lower segment ratio		Elevated ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis.
http://purl.obolibrary.org/obo/HP_0012775	Stellate iris	http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation		A lacy pattern or iris pigmentation that resembles the spokes of a bicycle wheel.
http://purl.obolibrary.org/obo/HP_0012778	Retinal astrocytic hamartoma	http://purl.obolibrary.org/obo/HP_0009594	Retinal hamartoma		A glial tumor of the retinal nerve fiber layer arising from a retinal astrocyte.
http://purl.obolibrary.org/obo/HP_0012779	Transient hearing impairment	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		Hearing loss that occurs acutely and resolves completely.
http://purl.obolibrary.org/obo/HP_0012780	Neoplasm of the ear	http://purl.obolibrary.org/obo/HP_0011793	Neoplasm by anatomical site		A tumor (abnormal growth of tissue) of the ear.
http://purl.obolibrary.org/obo/HP_0012781	Mid-frequency hearing loss	http://purl.obolibrary.org/obo/HP_0000365	Hearing impairment		A type of hearing impairment affecting primarily the middle frequencies of sound (1000 Hz to 3000 Hz).
http://purl.obolibrary.org/obo/HP_0012782	Perilobar nephrogenic rest	http://purl.obolibrary.org/obo/HP_0100880	Nephrogenic rest		A type of nephrogenic rest associated with multiple lesions in the periphery of the renal lobe.
http://purl.obolibrary.org/obo/HP_0012783	Intralobar nephrogenic rest	http://purl.obolibrary.org/obo/HP_0100880	Nephrogenic rest		A type of nephrogenic rest usually representing single lesions within the renal lobe, renal sinus, or calyceal walls.
http://purl.obolibrary.org/obo/HP_0012784	Perinephritis	http://purl.obolibrary.org/obo/HP_0000123	Nephritis		Inflammation of the connective and adipose tissues surrounding the kidney.
http://purl.obolibrary.org/obo/HP_0012786	Recurrent cystitis	http://purl.obolibrary.org/obo/HP_5210191	Unusual cystitis		Repeated infections of the urinary bladder.
http://purl.obolibrary.org/obo/HP_0012787	Recurrent pyelonephritis	http://purl.obolibrary.org/obo/HP_5210195	Unusual pyelonephritis		Repeated episodes of pyelonephritis.
http://purl.obolibrary.org/obo/HP_0012788	Reticulate pigmentation of oral mucosa	http://purl.obolibrary.org/obo/HP_0100669	Abnormal pigmentation of the oral mucosa		A net-like pattern of increased pigmentation of the oral cavity.
http://purl.obolibrary.org/obo/HP_0012789	Hypoplasia of the calcaneus	http://purl.obolibrary.org/obo/HP_0008363	Aplasia/Hypoplasia of the tarsal bones		Underdevelopment of the heel bone.
http://purl.obolibrary.org/obo/HP_0012790	Abnormal intramembranous ossification	http://purl.obolibrary.org/obo/HP_0011849	Abnormal bone ossification		An anomaly in the process of intramembranous ossification by which flat bones (cranial bones of the skull, i.e., the frontal, parietal, occipital, and temporal bones, and the clavicles) are formed.
http://purl.obolibrary.org/obo/HP_0012792	Absent ossification of thoracic vertebral bodies	http://purl.obolibrary.org/obo/HP_0004599	Absent or minimally ossified vertebral bodies		A lack of bone mineralization of one or more body of thoracic vertebra.
http://purl.obolibrary.org/obo/HP_0012793	Kinked brainstem	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		A kinked appearance of the brainstem, i.e., an exaggerated flexure.
http://purl.obolibrary.org/obo/HP_0012794	Periventricular white matter hypodensities	http://purl.obolibrary.org/obo/HP_0007103	Hypointensity of cerebral white matter on MRI		Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles.
http://purl.obolibrary.org/obo/HP_0012796	Increased cup-to-disc ratio	http://purl.obolibrary.org/obo/HP_0012795	Abnormal optic disc morphology		An elevation in the ratio of the diameter of the cup of the optic disc to the total diameter of the disk. The optic disc has an orange-pink rim with a pale center (the cup) that does not contain neuroretinal tissue. An increase in this ratio therefore may indicate a decrease in the quantity of healthy neuroretinal cells.
http://purl.obolibrary.org/obo/HP_0012797	Lymphatic vessel neoplasm	http://purl.obolibrary.org/obo/HP_0100766	Abnormal lymphatic vessel morphology		A benign or malignant neoplasm arising from the lymphatic vessels.
http://purl.obolibrary.org/obo/HP_0012798	Pulmonary lymphangiomyomatosis	http://purl.obolibrary.org/obo/HP_0012797	Lymphatic vessel neoplasm		Infiltration of smooth muscle-like cells in lymph vessels as well as the lung (pleura, alveolar septa, bronchi, pulmonary vessels and lymphatics as well as lymph nodes, especially in posterior mediastinum and retroperitoneum). Focal emphysema can develop because of airway narrowing, and the thoracic duct may be obliterated. Pulmonary lymphangiomyomatosis may lead to multiple small cysts with a hamartomatous proliferation of smooth muscle in their walls.
http://purl.obolibrary.org/obo/HP_0012799	Unilateral facial palsy	http://purl.obolibrary.org/obo/HP_0010628	Facial palsy		One-sided weakness of the muscles of facial expression and eye closure.
http://purl.obolibrary.org/obo/HP_0012800	Accessory cranial suture	http://purl.obolibrary.org/obo/HP_0011329	Abnormality of cranial sutures		A cranial suture that is in addition to canonical membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant.
http://purl.obolibrary.org/obo/HP_0012801	Narrow jaw	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		Bigonial distance (lower facial width) more than 2 standard deviations below the mean (objective); or an apparently decreased width of the lower jaw (mandible) when viewed from the front (subjective).
http://purl.obolibrary.org/obo/HP_0012802	Broad jaw	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		Bigonial distance (lower facial width) more than 2 SD above the mean (objective); or an apparently increased width of the lower jaw (mandible) when viewed from the front (subjective).
http://purl.obolibrary.org/obo/HP_0012803	Anisometropia	http://purl.obolibrary.org/obo/HP_0000539	Abnormality of refraction		Inequality of refractive power of the two eyes.
http://purl.obolibrary.org/obo/HP_0012805	Iris transillumination defect	http://purl.obolibrary.org/obo/HP_0008034	Abnormal iris pigmentation		Transmission of light through the iris as visualized upon slit lamp examination or infrared iris transillumination videography. The light passes through defects in the pigmentation of the iris.
http://purl.obolibrary.org/obo/HP_0012806	Proboscis	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		A fleshy, tube-like structure usually located in the midline of the face or just to one side of the midline.
http://purl.obolibrary.org/obo/HP_0012807	High insertion of columella	http://purl.obolibrary.org/obo/HP_0009929	Abnormal columella morphology		Insertion of the posterior columella superior to the nasal base.
http://purl.obolibrary.org/obo/HP_0012808	Abnormal nasal base norphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		An anomaly of the nasal base, which can be conceived of as an imaginary line between the most lateral points of the external inferior attachments of the alae nasi to the face.
http://purl.obolibrary.org/obo/HP_0012809	Narrow nasal base	http://purl.obolibrary.org/obo/HP_0012808	Abnormal nasal base norphology		Decreased distance between the attachments of the alae nasi to the face.
http://purl.obolibrary.org/obo/HP_0012810	Wide nasal base	http://purl.obolibrary.org/obo/HP_0012808	Abnormal nasal base norphology		Increased distance between the attachments of the alae nasi to the face.
http://purl.obolibrary.org/obo/HP_0012811	Wide nasal ridge	http://purl.obolibrary.org/obo/HP_0011119	Abnormal nasal dorsum morphology		Increased width of the nasal ridge.
http://purl.obolibrary.org/obo/HP_0012813	Unilateral breast hypoplasia	http://purl.obolibrary.org/obo/HP_0003187	Breast hypoplasia		Underdevelopment of the breast on one side only.
http://purl.obolibrary.org/obo/HP_0012814	Bilateral breast hypoplasia	http://purl.obolibrary.org/obo/HP_0003187	Breast hypoplasia		Underdevelopment of the breast on both sides.
http://purl.obolibrary.org/obo/HP_0012816	Right ventricular noncompaction cardiomyopathy	http://purl.obolibrary.org/obo/HP_0012817	Noncompaction cardiomyopathy		A predominantly right ventricular variant of isolated noncompaction cardiomyopathy.
http://purl.obolibrary.org/obo/HP_0012818	Biventricular noncompaction cardiomyopathy	http://purl.obolibrary.org/obo/HP_0012817	Noncompaction cardiomyopathy		Noncompaction cardiomyopathy that affects both ventricles.
http://purl.obolibrary.org/obo/HP_0012819	Myocarditis	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Inflammation of the myocardium.
http://purl.obolibrary.org/obo/HP_0012820	Bilateral vocal cord paralysis	http://purl.obolibrary.org/obo/HP_0001605	Vocal cord paralysis		A loss of the ability to move the vocal fold on both sides.
http://purl.obolibrary.org/obo/HP_0012821	Unilateral vocal cord paresis	http://purl.obolibrary.org/obo/HP_0001604	Vocal cord paresis		Decreased strength of the vocal fold on one side.
http://purl.obolibrary.org/obo/HP_0012822	Bilateral vocal cord paresis	http://purl.obolibrary.org/obo/HP_0001604	Vocal cord paresis		Decreased strength of the vocal fold on both sides.
http://purl.obolibrary.org/obo/HP_0012824	Severity	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		The intensity or degree of a manifestation.
http://purl.obolibrary.org/obo/HP_0012825	Mild	http://purl.obolibrary.org/obo/HP_0012824	Severity		Having a relatively minor degree of severity. For quantitative traits, a deviation of between two and three standard deviations from the appropriate population mean.
http://purl.obolibrary.org/obo/HP_0012826	Moderate	http://purl.obolibrary.org/obo/HP_0012824	Severity		Having a medium degree of severity. For quantitative traits, a deviation of between three and four standard deviations from the appropriate population mean.
http://purl.obolibrary.org/obo/HP_0012827	Borderline	http://purl.obolibrary.org/obo/HP_0012824	Severity		Having a minor degree of severity that is considered to be on the boundary between the normal and the abnormal ranges. For quantitative traits, a deviation of that is less than two standard deviations from the appropriate population mean.
http://purl.obolibrary.org/obo/HP_0012828	Severe	http://purl.obolibrary.org/obo/HP_0012824	Severity		Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean.
http://purl.obolibrary.org/obo/HP_0012829	Profound	http://purl.obolibrary.org/obo/HP_0012824	Severity		Having an extremely high degree of severity. For quantitative traits, a deviation of more than five standard deviations from the appropriate population mean.
http://purl.obolibrary.org/obo/HP_0012831	Laterality	http://purl.obolibrary.org/obo/HP_0012830	Position		The localization with respect to the side of the body of the specified phenotypic abnormality.
http://purl.obolibrary.org/obo/HP_0012832	Bilateral	http://purl.obolibrary.org/obo/HP_0012831	Laterality		Being present on both sides of the body.
http://purl.obolibrary.org/obo/HP_0012833	Unilateral	http://purl.obolibrary.org/obo/HP_0012831	Laterality		Being present on only the left or only the right side of the body.
http://purl.obolibrary.org/obo/HP_0012834	Right	http://purl.obolibrary.org/obo/HP_0012831	Laterality		Being located on the right side of the body.
http://purl.obolibrary.org/obo/HP_0012835	Left	http://purl.obolibrary.org/obo/HP_0012831	Laterality		Being located on the left side of the body.
http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern	http://purl.obolibrary.org/obo/HP_0012830	Position		The pattern by which a phenotype affects one or more regions of the body.
http://purl.obolibrary.org/obo/HP_0012837	Generalized	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Affecting all regions without specificity of distribution.
http://purl.obolibrary.org/obo/HP_0012838	Localized	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Being confined or restricted to a particular location.
http://purl.obolibrary.org/obo/HP_0012839	Distal	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Localized away from the central point of the body.
http://purl.obolibrary.org/obo/HP_0012840	Proximal	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Localized close to the central point of the body.
http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm	http://purl.obolibrary.org/obo/HP_0011138	Abnormal skin adnexa morphology		A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands.
http://purl.obolibrary.org/obo/HP_0012843	Hair follicle neoplasm	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		An uncontrolled autonomous cell-proliferation originating in a hair follicle, which is an epidermal adnexal structures responsible for hair growth.
http://purl.obolibrary.org/obo/HP_0012844	Trichilemmoma	http://purl.obolibrary.org/obo/HP_0012843	Hair follicle neoplasm		A benign tumor originating from the outer root sheath of the hair follicle.
http://purl.obolibrary.org/obo/HP_0012845	Single trichilemmoma	http://purl.obolibrary.org/obo/HP_0012844	Trichilemmoma		Presence of a unitary trichilemmoma, a benign tumor originating from the outer root sheath of the hair follicle.
http://purl.obolibrary.org/obo/HP_0012846	Multiple trichilemmomata	http://purl.obolibrary.org/obo/HP_0012844	Trichilemmoma		Presence of multiple trichilemmomata, a benign tumor originating from the outer root sheath of the hair follicle.
http://purl.obolibrary.org/obo/HP_0012847	Epilepsia partialis continua	http://purl.obolibrary.org/obo/HP_0032663	Focal motor status epilepticus		Epilepsia partialis continua (also called Kojevnikov's or Kozhevnikov's epilepsia) is a type of focal motor status epilepticus characterized by repeated stereotyped simple motor manifestations such as jerks, typically of a limb or the face, recurring every few seconds or minutes for extended periods (days or years).
http://purl.obolibrary.org/obo/HP_0012848	Small intestinal stenosis	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		The narrowing or partial blockage of a portion of the small intestine.
http://purl.obolibrary.org/obo/HP_0012849	Small intestinal bleeding	http://purl.obolibrary.org/obo/HP_0002584	Intestinal bleeding		Bleeding from the small intestine.
http://purl.obolibrary.org/obo/HP_0012850	Small intestinal dysmotility	http://purl.obolibrary.org/obo/HP_0002579	Gastrointestinal dysmotility		Abnormal small intestinal contractions, such as spasms and intestinal paralysis related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes.
http://purl.obolibrary.org/obo/HP_0012851	Colonic stenosis	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		A narrowing of a segment of colon whereby bowel continuity is maintained.
http://purl.obolibrary.org/obo/HP_0012852	Hepatic bridging fibrosis	http://purl.obolibrary.org/obo/HP_0001395	Hepatic fibrosis		Hepatic fibrosis that reaches from a portal area to another portal area.
http://purl.obolibrary.org/obo/HP_0012853	Scrotal hypospadias	http://purl.obolibrary.org/obo/HP_0000047	Hypospadias		Hypospadias with location of the urethral meatus in the scrotum.
http://purl.obolibrary.org/obo/HP_0012854	Midshaft hypospadias	http://purl.obolibrary.org/obo/HP_0003244	Penile hypospadias		Hypospadias with location of the urethral meatus in the middle of the inferior shaft of the penis.
http://purl.obolibrary.org/obo/HP_0012855	Scrotal hyperpigmentation	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Increased pigmentation (skin color) of the scrotum.
http://purl.obolibrary.org/obo/HP_0012856	Abnormal scrotal rugation	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Anomaly of the folded ridges (wrinkles) of skin of the scrotum.
http://purl.obolibrary.org/obo/HP_0012857	Increased scrotal rugation	http://purl.obolibrary.org/obo/HP_0012856	Abnormal scrotal rugation		Increased number or density of the folded ridges (wrinkles) of skin of the scrotum.
http://purl.obolibrary.org/obo/HP_0012858	Decreased scrotal rugation	http://purl.obolibrary.org/obo/HP_0012856	Abnormal scrotal rugation		Decreased number or density of the folded ridges (wrinkles) of skin of the scrotum.
http://purl.obolibrary.org/obo/HP_0012859	Esophageal leukoplakia	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		A white patch or plaque occurring on the surface of the esophageal mucous membranes that cannot be rubbed off and cannot be characterized clinically as any other disease.
http://purl.obolibrary.org/obo/HP_0012860	Testicular fibrosis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Formation of excess connective tissue in the testicle.
http://purl.obolibrary.org/obo/HP_0012861	Ovotestis	http://purl.obolibrary.org/obo/HP_0000062	Ambiguous genitalia		A gonad that contains both ovarian follicles and testicular tubular elements.
http://purl.obolibrary.org/obo/HP_0012862	Abnormal germ cell morphology	http://purl.obolibrary.org/obo/HP_0012243	Abnormal reproductive system morphology		Any structural anomaly of a reproductive cell.
http://purl.obolibrary.org/obo/HP_0012863	Abnormal male germ cell morphology	http://purl.obolibrary.org/obo/HP_0012862	Abnormal germ cell morphology		A structural anomaly of a male reproductive cell.
http://purl.obolibrary.org/obo/HP_0012864	Abnormal sperm morphology	http://purl.obolibrary.org/obo/HP_0012863	Abnormal male germ cell morphology		A structural anomaly of sperm.
http://purl.obolibrary.org/obo/HP_0012866	Abnormal sperm neck morphology	http://purl.obolibrary.org/obo/HP_0012864	Abnormal sperm morphology		A structural abnormality of the sperm neck.
http://purl.obolibrary.org/obo/HP_0012867	Abnormal sperm mid-piece morphology	http://purl.obolibrary.org/obo/HP_0012864	Abnormal sperm morphology		A structural abnormality of the sperm mid-piece.
http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology	http://purl.obolibrary.org/obo/HP_0012864	Abnormal sperm morphology		A structural abnormality of the sperm tail.
http://purl.obolibrary.org/obo/HP_0012869	Acephalic spermatozoa	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Spermatozoa with very small cranial ends devoid of any nuclear material, that is, lacking a typical sperm head.
http://purl.obolibrary.org/obo/HP_0012870	Vanishing testis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		A condition which is considered to be due to the subsequent atrophy and disappearance in fetal life of an initially normal testis. In the presence of spermatic cord structures is evidence of the presence of the testis in early intrauterine life. When associated with a blind-ending spermatic cord, this entity is named as his absence of a testis in an otherwise normal 46XY male is usually unilateral and is assumed to be a consequence of intrauterine or perinatal torsion or infarction.
http://purl.obolibrary.org/obo/HP_0012871	Varicocele	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		A varicocele is a widening of the veins along the spermatic cord, leading to enlarged, twisted veins in the scrotum, and manifested clinically by a painless testicle lump, scrotal swelling, or bulge in the scrotum.
http://purl.obolibrary.org/obo/HP_0012872	Abnormal vas deferens morphology	http://purl.obolibrary.org/obo/HP_0000022	Abnormal male internal genitalia morphology		A structural anomaly of the secretory duct of the testicle that carries spermatozoa from the epididymis to the prostatic urethra where it terminates to form ejaculatory duct.
http://purl.obolibrary.org/obo/HP_0012873	Absent vas deferens	http://purl.obolibrary.org/obo/HP_0012872	Abnormal vas deferens morphology		Aplasia (congenital absence) of the vas deferens.
http://purl.obolibrary.org/obo/HP_0012875	Abnormal ejaculation	http://purl.obolibrary.org/obo/HP_0012874	Abnormal male reproductive system physiology		Abnormality in the process of ejection of semen (usually carrying sperm) from the male reproductive tract.
http://purl.obolibrary.org/obo/HP_0012876	Premature ejaculation	http://purl.obolibrary.org/obo/HP_0012875	Abnormal ejaculation		The emission of semen and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration.
http://purl.obolibrary.org/obo/HP_0012877	Retrograde ejaculation	http://purl.obolibrary.org/obo/HP_0012875	Abnormal ejaculation		The emission of semen and seminal fluid into the bladder instead of through the penis during orgasm.
http://purl.obolibrary.org/obo/HP_0012878	Retarded ejaculation	http://purl.obolibrary.org/obo/HP_0012875	Abnormal ejaculation		Difficulty of a male in achieving orgasm.
http://purl.obolibrary.org/obo/HP_0012879	Anejaculation	http://purl.obolibrary.org/obo/HP_0012875	Abnormal ejaculation		Inability to ejaculate.
http://purl.obolibrary.org/obo/HP_0012882	Hyperplastic labia majora	http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology		Overgrowth of the outer labia.
http://purl.obolibrary.org/obo/HP_0012883	Fallopian tube cyst	http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology		A fluid filled sac located in the Fallopian tube.
http://purl.obolibrary.org/obo/HP_0012884	Fallopian tube torsion	http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology		A twisting of the Fallopian tube. Sudden onset with sharp, colicky pelvic pain associated with nausea, vomiting, bowel, and bladder symptoms is the usual presentation.
http://purl.obolibrary.org/obo/HP_0012885	Fallopian tube duplication	http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology		The presence of a supernumerary Fallopian tube.
http://purl.obolibrary.org/obo/HP_0012886	Hemorrhagic ovarian cyst	http://purl.obolibrary.org/obo/HP_0000138	Ovarian cyst		An abdominal mass formed by bleeding into a follicular ovarian cyst or corpus luteum cyst.
http://purl.obolibrary.org/obo/HP_0012887	Ovarian serous cystadenoma	http://purl.obolibrary.org/obo/HP_0000138	Ovarian cyst		A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue.
http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology	http://purl.obolibrary.org/obo/HP_0000130	Abnormality of the uterus		An anomaly of the neck of the uterus (lower part of the uterus), called the uterine cervix.
http://purl.obolibrary.org/obo/HP_0012889	Cervical endometriosis	http://purl.obolibrary.org/obo/HP_0030127	Endometriosis		Abnormal growth of endometrial cells (which are normally limited to the uterus) within the cervix.
http://purl.obolibrary.org/obo/HP_0012890	Posteriorly placed anus	http://purl.obolibrary.org/obo/HP_0004397	Ectopic anus		Posterior malposition of the anus.
http://purl.obolibrary.org/obo/HP_0012891	High posterior hairline	http://purl.obolibrary.org/obo/HP_0030141	Abnormality of the posterior hairline		Hair on the neck extends less inferiorly than usual.
http://purl.obolibrary.org/obo/HP_0012892	Facial muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0003712	Skeletal muscle hypertrophy		Hypertrophy of one or more muscles innervated by the facial nerve (the seventh cranial nerve).
http://purl.obolibrary.org/obo/HP_0012893	Neck muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0011006	Abnormal morphology of the musculature of the neck		Muscle hypertrophy affecting the muscles of the neck.
http://purl.obolibrary.org/obo/HP_0012894	Paraspinal muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0003712	Skeletal muscle hypertrophy		Muscle hypertrophy affecting the paraspinal muscles.
http://purl.obolibrary.org/obo/HP_0012895	Scapular muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0003712	Skeletal muscle hypertrophy		Muscle hypertrophy affecting the scapular muscles.
http://purl.obolibrary.org/obo/HP_0012896	Abnormal motor evoked potentials	http://purl.obolibrary.org/obo/HP_0430106	Abnormal brain-evoked potentials		An anomaly identified by motor evoked potentials (MEPs). MEPs are measured following single-pulse or repetitive transcranial magnetic stimulation and can be used for the assessment of the excitability of the motor cortex and the integrity of conduction along the central and peripheral motor pathways.
http://purl.obolibrary.org/obo/HP_0012897	Abnormal upper-limb motor evoked potentials	http://purl.obolibrary.org/obo/HP_0012896	Abnormal motor evoked potentials		An anomaly identified by motor evoked potentials (MEPs) in the arm.
http://purl.obolibrary.org/obo/HP_0012898	Abnormal lower-limb motor evoked potentials	http://purl.obolibrary.org/obo/HP_0012896	Abnormal motor evoked potentials		An anomaly identified by motor evoked potentials (MEPs) in the leg.
http://purl.obolibrary.org/obo/HP_0012899	Handgrip myotonia	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		Difficulty releasing one's grip associated with prolonged first handgrip relaxation times.
http://purl.obolibrary.org/obo/HP_0012900	Myotonia of the face	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		Slowed relaxation of muscles in the face.
http://purl.obolibrary.org/obo/HP_0012901	Myotonia of the jaw	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		Slowed relaxation of muscles in the jaw.
http://purl.obolibrary.org/obo/HP_0012902	Myotonia of the lower limb	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		Slowed relaxation of muscles in the leg.
http://purl.obolibrary.org/obo/HP_0012903	Myotonia of the upper limb	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		Slowed relaxation of muscles in the arm.
http://purl.obolibrary.org/obo/HP_0012904	Cold-sensitive myotonia	http://purl.obolibrary.org/obo/HP_0002486	Myotonia		An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation that is induced by exposure to cold.
http://purl.obolibrary.org/obo/HP_0012905	Euryblepharon	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Euryblepharon is a congenital eyelid anomaly characterized by horizontal enlargement of the palpebral fissure. The eyelid is shortened vertically compared with the horizontal dimension, with associated lateral canthal malpositioning and lateral ectropion abnormally wide lid opening.
http://purl.obolibrary.org/obo/HP_0020006	Ciliary body coloboma	http://purl.obolibrary.org/obo/HP_0000589	Coloboma		A coloboma of the ciliary body.
http://purl.obolibrary.org/obo/HP_0020034	Diffuse	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		A spatial pattern that is spread out, i.e., not localized.
http://purl.obolibrary.org/obo/HP_0025004	Hallux rigidus	http://purl.obolibrary.org/obo/HP_0001844	Abnormal hallux morphology		Osteoarthritis of the metatarsophalangeal joint of the first toe.
http://purl.obolibrary.org/obo/HP_0025005	Thickening of glomerular capillary wall	http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology		Widening of the wall of capillary blood vessels in the glomerulus. This feature may be produced by deposits and other changes affecting either subepithelial and subendothelial regions or the glomerular basement membrane itself.
http://purl.obolibrary.org/obo/HP_0025006	Abnormal glomerular capillary morphology	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		A structural anomaly of the capillary blood vessels in the renal glomerulus.
http://purl.obolibrary.org/obo/HP_0025007	Ectopic fovea	http://purl.obolibrary.org/obo/HP_0000493	Abnormal foveal morphology		An abnormal anatomic position of the fovea.
http://purl.obolibrary.org/obo/HP_0025008	Tracheal tug on inspiration	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Downward movement of the trachea during inspiration due to downward traction on the tracheobronchial tree.
http://purl.obolibrary.org/obo/HP_0025009	Forward slanting upper incisors	http://purl.obolibrary.org/obo/HP_0011062	Misalignment of incisors		The upper incisors deviate from the normal angle of being roughly parallel to the surface of the face and instead slant outwards.
http://purl.obolibrary.org/obo/HP_0025010	Foveal atrophy	http://purl.obolibrary.org/obo/HP_0000493	Abnormal foveal morphology		A nonspecific term denoting wasting, especially as a result of degeneration, of the retinal pigment epithelium (RPE) and neurosensory retinal cells in the fovea.
http://purl.obolibrary.org/obo/HP_0025011	Pyriform aperture stenosis	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		Narrowing of the anterior nasal aperture (piriform or pyriform aperture), which is a pear-shaped opening in the skull that forms the bony inlet of the nose.
http://purl.obolibrary.org/obo/HP_0025012	Status cribrosum	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		Diffusely widened perivascular spaces in the basal ganglia, affecting especially the corpus striatum. Status cribrosum is usually symmetrical, with the perivascular spaces showing CSF signal and without diffusion restriction. The word cribriform means sievelike, with multiple perforations.
http://purl.obolibrary.org/obo/HP_0025013	Decerebrate rigidity	http://purl.obolibrary.org/obo/HP_0002063	Rigidity		A type of rigidity that is manifested by an exaggerated extensor posture of all extremities.
http://purl.obolibrary.org/obo/HP_0025014	Subcutaneous spheroids	http://purl.obolibrary.org/obo/HP_0001482	Subcutaneous nodule		Small, hard cyst-like nodules, freely moveable in the subcutis over the bony prominences of the legs and arms, which have an outer calcified layer with a translucent core on x-ray.
http://purl.obolibrary.org/obo/HP_0025016	Abnormal capillary morphology	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		A structural anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues.
http://purl.obolibrary.org/obo/HP_0025017	Capillary fragility	http://purl.obolibrary.org/obo/HP_0025018	Abnormal capillary physiology		Reduced resistance to rupture of capillary blood vessels. Capillary fragility may manifest as a bleeding diathesis with spontaneous ecchymoses (bruises).
http://purl.obolibrary.org/obo/HP_0025018	Abnormal capillary physiology	http://purl.obolibrary.org/obo/HP_0030163	Abnormal vascular physiology		A functional anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues.
http://purl.obolibrary.org/obo/HP_0025019	Arterial rupture	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Sudden breakage of an artery leading to leakage of blood from the circulation.
http://purl.obolibrary.org/obo/HP_0025020	Elevated circulating prostate-specific antigen concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of prostate-specific antigen in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025022	Decreased erythrocyte sedimentation rate	http://purl.obolibrary.org/obo/HP_0025021	Abnormal erythrocyte sedimentation rate		A reduced erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.
http://purl.obolibrary.org/obo/HP_0025023	Rectal atresia	http://purl.obolibrary.org/obo/HP_0011100	Intestinal atresia		A developmental defect resulting in complete obliteration of the lumen of the rectum. That is, there is an abnormal closure, or atresia of the tubular structure of the rectum.
http://purl.obolibrary.org/obo/HP_0025024	Megarectum	http://purl.obolibrary.org/obo/HP_0002034	Abnormal rectum morphology		An abnormal dilation of the rectum. There is a large filled rectum as a result of underlying innervation or muscular abnormalities, which remains after disimpaction of the rectum.
http://purl.obolibrary.org/obo/HP_0025025	Rectovestibular fistula	http://purl.obolibrary.org/obo/HP_0100590	Rectal fistula		A congenital malformation characterized by an abnormal connection (fistula) between the rectum and the vulval vestibule, at the lower aspect of the vaginal opening.
http://purl.obolibrary.org/obo/HP_0025026	H-type rectovestibular fistula	http://purl.obolibrary.org/obo/HP_0025025	Rectovestibular fistula		Rectovestibular fistula with a normal anus is known as H-type fistula or double termination of the alimentary tract.
http://purl.obolibrary.org/obo/HP_0025027	Osteoma cutis	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		The term osteoma refers to the anomalous presence of ossification (bone formation) in the interior of the dermis or epidermis. The dermal or subcutaneous bone formation presents as stony hard nodules. The osteomata appear as irregular, hardened small nodules that are well circumscribed and generally of the same color as the skin.
http://purl.obolibrary.org/obo/HP_0025030	Enteric neuronal degeneration	http://purl.obolibrary.org/obo/HP_0025029	Abnormal enteric neuron morphology		Deterioration of enteric neurons with impairment of enteric neuronal structure. Typical neuropathological findings include qualitative (e.g., neuronal swelling, intranuclear inclusions, axonal degeneration) and quantitative (e.g., reduction in the number of neurons) abnormalities of the enteric neurons.
http://purl.obolibrary.org/obo/HP_0025033	Abnormal digestive system morphology	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		A structural anomaly of the digestive system.
http://purl.obolibrary.org/obo/HP_0025034	Abnormal morphology of erythroid progenitor cell	http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology		Abnormal form of the progenitor cells committed to the erythroid lineage.
http://purl.obolibrary.org/obo/HP_0025035	Abnormal proerythroblast morphology	http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology		Anomalous form of the proerythroblast, i.e., the immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.
http://purl.obolibrary.org/obo/HP_0025037	Hypothalamic gliosis	http://purl.obolibrary.org/obo/HP_0002171	Gliosis		Focal proliferation of glial cells in the hypothalamus.
http://purl.obolibrary.org/obo/HP_0025038	Intratesticular abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A collection of pus within a testicle. Ultrasonographic features include shaggy, irregular walls, intratesticular location, low-level internal echoes, and occasionally, hypervascular margins.
http://purl.obolibrary.org/obo/HP_0025039	Basal ganglia edema	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		Swelling within the basal ganglia due to the accumulation of fluid.
http://purl.obolibrary.org/obo/HP_0025040	Thalamic edema	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		Swelling within the thalamus due to the accumulation of fluid.
http://purl.obolibrary.org/obo/HP_0025041	Thalamic calcification	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		Calcium deposition in the thalamus.
http://purl.obolibrary.org/obo/HP_0025042	Abnormality of mesenteric lymph nodes	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		A morphological anomaly of lymph nodes in the mesenteric root or throughout the mesentery.
http://purl.obolibrary.org/obo/HP_0025043	Enlarged mesenteric lymph node	http://purl.obolibrary.org/obo/HP_0025042	Abnormality of mesenteric lymph nodes		Increase in size of one or more mesenteric lymph nodes.
http://purl.obolibrary.org/obo/HP_0025044	Lung abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A circumscribed area of pus or necrotic debris in lung parenchyma, which leads to a cavity, and after formation of bronchopulmonary fistula, can manifest as an air-fluid level inside the cavity.
http://purl.obolibrary.org/obo/HP_0025045	Abnormal brain lactate level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		A deviation from normal of the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025046	Reduced brain lactate level by MRS	http://purl.obolibrary.org/obo/HP_0025045	Abnormal brain lactate level by MRS		A decrease in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025047	Abnormal brain choline level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		A deviation from normal in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025048	Reduced brain choline level by MRS	http://purl.obolibrary.org/obo/HP_0025047	Abnormal brain choline level by MRS		An decrease in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025050	Elevated brain creatine level by MRS	http://purl.obolibrary.org/obo/HP_0025049	Abnormal brain creatine level by MRS		An increase in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025051	Reduced brain creatine level by MRS	http://purl.obolibrary.org/obo/HP_0025049	Abnormal brain creatine level by MRS		A decrease in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025052	Abnormal brain N-acetyl aspartate level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		A deviation from normal in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025053	Elevated brain N-acetyl aspartate level by MRS	http://purl.obolibrary.org/obo/HP_0025052	Abnormal brain N-acetyl aspartate level by MRS		An increase in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025058	Hypothalamic atrophy	http://purl.obolibrary.org/obo/HP_0012286	Abnormal hypothalamus morphology		Partial or complete wasting (loss) of hypothalamus tissue that was once present.
http://purl.obolibrary.org/obo/HP_0025059	Splenic abscess	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		A circumscribed area of pus or necrotic debris in the parenchyma of the spleen.
http://purl.obolibrary.org/obo/HP_0025060	Multifocal splenic abscess	http://purl.obolibrary.org/obo/HP_0025059	Splenic abscess		Multiple abscess lesions in the spleen.
http://purl.obolibrary.org/obo/HP_0025061	Unifocal splenic abscess	http://purl.obolibrary.org/obo/HP_0025059	Splenic abscess		Single (solitary) abscess in the spleen.
http://purl.obolibrary.org/obo/HP_0025062	Geophagia	http://purl.obolibrary.org/obo/HP_0011856	Pica		The practice of eating earth or soil-like substrates such as clay or chalk.
http://purl.obolibrary.org/obo/HP_0025063	Scaphoid abdomen	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		The anterior abdominal wall is sunken and presents a concave rather than a convex contour.
http://purl.obolibrary.org/obo/HP_0025064	Thalamic hemorrhage	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		Bleeding in the thalamus.
http://purl.obolibrary.org/obo/HP_0025066	Decreased mean corpuscular volume	http://purl.obolibrary.org/obo/HP_0025065	Abnormal mean corpuscular volume		A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters).
http://purl.obolibrary.org/obo/HP_0025068	Incomitant strabismus	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		Strabismus in which the angle of deviation differs depending upon the direction of gaze or according to which eye is fixing, associated with: (i) defective movement of the eye, (ii) asymmetrical accommodative effort.
http://purl.obolibrary.org/obo/HP_0025069	Concomitant strabismus	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		Strabismus in which the angle of deviation of the squiting eye remains the same in relation to the other eye, in all directions of gaze, and whichever eye is fixing.
http://purl.obolibrary.org/obo/HP_0025070	Abnormal U wave	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		An anomaly of the U wave of the electrocardiogram (EKG). The U wave is a small (0.5 mm) deflection immediately following the T wave, usually in the same direction as the T wave. It is best seen in leads V2 and V3.
http://purl.obolibrary.org/obo/HP_0025071	U wave inversion	http://purl.obolibrary.org/obo/HP_0025070	Abnormal U wave		Direction of the U wave opposite to the T wave (i.e., below baseline) in leads with upright T waves.
http://purl.obolibrary.org/obo/HP_0025072	Prominent U wave	http://purl.obolibrary.org/obo/HP_0025070	Abnormal U wave		Increased amplitude of the U wave, defined as an amplitude greater than 1-2mm or 25 percent of the height of the T wave.
http://purl.obolibrary.org/obo/HP_0025073	Exercise-induced U wave inversion	http://purl.obolibrary.org/obo/HP_0025071	U wave inversion		U wave inversion that is induced by exercise stress testing.
http://purl.obolibrary.org/obo/HP_0025075	Increased QRS voltage	http://purl.obolibrary.org/obo/HP_0025076	Abnormal QRS voltage		Elevation of the voltage (height) of the QRS complex. There are several criteria in use, but the most common is the Sokolov-Lyon criterion (S wave depth in V1 + tallest R wave height in V5-V6 greater than 35 mm).
http://purl.obolibrary.org/obo/HP_0025076	Abnormal QRS voltage	http://purl.obolibrary.org/obo/HP_0025074	Abnormal QRS complex		Abnormal amplitude of the QRS complex of the electrocardiogram (EKG).
http://purl.obolibrary.org/obo/HP_0025077	Decreased QRS voltage	http://purl.obolibrary.org/obo/HP_0025076	Abnormal QRS voltage		Reduced amplitude (height) of the QRS complex of the electrocardiogram (EKG), defined as amplitudes of all the QRS complexes in the limb leads are less than 5 mm or amplitudes of all the QRS complexes in the precordial leads less than 10 mm.
http://purl.obolibrary.org/obo/HP_0025078	Electrical alternans	http://purl.obolibrary.org/obo/HP_0025076	Abnormal QRS voltage		The QRS complexes of the electrocardiogram alternate in height.
http://purl.obolibrary.org/obo/HP_0025079	Pancreatic abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A circumscribed area of pus or necrotic debris in the parenchyma of the pancreas.
http://purl.obolibrary.org/obo/HP_0025080	Orthokeratotic hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		A form of hyperkeratosis characterized by thickening of the cornified layer without retained nuclei.
http://purl.obolibrary.org/obo/HP_0025081	Darier's sign	http://purl.obolibrary.org/obo/HP_0001025	Urticaria		A skin change elicited by briskly rubbing the skin lesion in urticaria pigmentosa (UP), whereby the area begins to itch and becomes raised and surrounded by erythema. Unlike other forms of dermatographism, Darier's sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP.
http://purl.obolibrary.org/obo/HP_0025082	Abnormal cutaneous elastic fiber morphology	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Any structural anomaly of the elastic fibers of the skin. Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils.
http://purl.obolibrary.org/obo/HP_0025083	Elevated dermal desmosine content	http://purl.obolibrary.org/obo/HP_0034924	Abnormal dermis morphology		An increased amount of desmosine measure in the skin. Desmosine is a cross-linking amino acid formed from lysyl residues in elastin.
http://purl.obolibrary.org/obo/HP_0025084	Folliculitis	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Inflammatory cells within the wall and ostia of the hair follicle, creating a follicular-based pustule.
http://purl.obolibrary.org/obo/HP_0025086	Bloody mucoid diarrhea	http://purl.obolibrary.org/obo/HP_0025085	Bloody diarrhea		Passage of many stools containing blood and mucus.
http://purl.obolibrary.org/obo/HP_0025087	Delayed recoil upon stretching of skin	http://purl.obolibrary.org/obo/HP_0008067	Abnormally lax or hyperextensible skin		Area of skin requiring an increased amount of time to return to its original shape after being stretched.
http://purl.obolibrary.org/obo/HP_0025088	Onychomadesis	http://purl.obolibrary.org/obo/HP_0001806	Onycholysis		Complete shedding (separation) of the nail from the proximal matrix. Onychomadesis is the proximal separation of the nail plate from the nail matrix due to a temporary cessation of nail growth.
http://purl.obolibrary.org/obo/HP_0025089	Feculent vomiting	http://purl.obolibrary.org/obo/HP_0002013	Vomiting		Vomiting of material that is of fecal origin.
http://purl.obolibrary.org/obo/HP_0025090	Abnormal large intestinal mucosa morphology	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		A structural anomaly of the mucous lining of the large intestine.
http://purl.obolibrary.org/obo/HP_0025092	Epidermal acanthosis	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin).
http://purl.obolibrary.org/obo/HP_0025093	Peripapillary exudate	http://purl.obolibrary.org/obo/HP_0001147	Retinal exudate		A retinal exudate in the area surrounding the optic nerve head.
http://purl.obolibrary.org/obo/HP_0025094	Disciform macular scar	http://purl.obolibrary.org/obo/HP_0200056	Macular scar		A scar with a disc-like shape localized in the macula.
http://purl.obolibrary.org/obo/HP_0025095	Sneeze	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A sudden violent, spasmodic, audible expiration of breath through the nose and mouth.
http://purl.obolibrary.org/obo/HP_0025096	Paroxysmal sneezing	http://purl.obolibrary.org/obo/HP_0025095	Sneeze		Unprovoked explosive pathological sneezing.
http://purl.obolibrary.org/obo/HP_0025097	Eyelid myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		Marked, involuntary jerking of the eyelids.
http://purl.obolibrary.org/obo/HP_0025098	Dysgenesis of the hypothalamus	http://purl.obolibrary.org/obo/HP_0012286	Abnormal hypothalamus morphology		Structural abnormality of the hypothalamus related to defective development.
http://purl.obolibrary.org/obo/HP_0025099	Dysgenesis of the thalamus	http://purl.obolibrary.org/obo/HP_0010663	Abnormal thalamus morphology		Structural abnormality of the thalamus related to defective development.
http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology	http://purl.obolibrary.org/obo/HP_0007343	Abnormal morphology of the limbic system		Any structural anomaly of the hippocampus,
http://purl.obolibrary.org/obo/HP_0025101	Dysgenesis of the hippocampus	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		Structural abnormality of the hippocampus related to defective development.
http://purl.obolibrary.org/obo/HP_0025102	Dysgenesis of the basal ganglia	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		Structural abnormality of the basal ganglia related to defective development.
http://purl.obolibrary.org/obo/HP_0025103	Umbilicated nodule	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		A type of skin nodule that has a small depression that resembles a navel (i.e., is umbilicated).
http://purl.obolibrary.org/obo/HP_0025105	Nevus anemicus	http://purl.obolibrary.org/obo/HP_0025104	Capillary malformation		A congenital skin lesion characterized by irregular hypopigmented macules that coalesce to form plaques and occur particularly on the chest. It is generally present at birth or develops in the first days of life. It is more common in females. Diagnosis is confirmed by applying gentle friction to the lesion and the surrounding skin and checking that the erythema produced in the healthy skin does not appear in the hypopigmented lesion. This pale macule becomes more conspicuous when the lesion and its surroundings are rubbed. The margin of the naevus is ill-defined and consists of an archipelago of small anemic spots.
http://purl.obolibrary.org/obo/HP_0025106	Nevus roseus	http://purl.obolibrary.org/obo/HP_0025104	Capillary malformation		A variant of port-wine stain characterized by a pale red or even pink tone, in contrast to the darker hue of the port-wine stain. By analogy with the term port-wine stain, this variant rose-wine stain, or nevus roseus. Nevus roseus, however, cannot be definitely diagnosed until adulthood as port-wine stains are sometimes pink in children. While the natural history of port-wine stains includes hypertrophy, darkening, and nodularity, nevus roseus remains unchanged for life.
http://purl.obolibrary.org/obo/HP_0025107	Cutis marmorata telangiectatica congenita	http://purl.obolibrary.org/obo/HP_0025104	Capillary malformation		A congenital vascular malformation that presents as localized or generalized erythematous-telangiectatic lesions with a reticular pattern; the lesions are almost always present at birth or develop in the first days of life. Cutis marmorata telangiectatica congenita (CMTC) appears as marble-like pattern (mottling) on the surface of the skin. In contrast to cutis marmorata, the marbling is more severe and always visible.
http://purl.obolibrary.org/obo/HP_0025108	Angioma serpentinum	http://purl.obolibrary.org/obo/HP_0025104	Capillary malformation		Angioma serpiginosum consists of punctate, tightly packed telangiectatic lesions. Characteristic histopathological features are dilated and tortuous capillaries involving the uppermost part of the dermis.
http://purl.obolibrary.org/obo/HP_0025109	Reduced red cell pyruvate kinase level	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Decrease in the level of pyruvate kinase (PK) within erythrocytes. PK catalyzes the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.
http://purl.obolibrary.org/obo/HP_0025110	Placoid macular lesion	http://purl.obolibrary.org/obo/HP_0030500	Yellow/white macular lesion		Large yellow/white, sharply delineated lesion, typically of inflammatory nature, involving the macula, more specifically at the outer retinal level (RPE/photoreceptor).
http://purl.obolibrary.org/obo/HP_0025113	Misophonia	http://purl.obolibrary.org/obo/HP_5200060	Auditory hypersensitivity		Misophonia is characterized by strong physiological, emotional, and behavioral reactions to auditory, visual, and/or kinesthetic stimuli of different nature regardless of their physical characteristics. These misophonic responses include anger, general discomfort, disgust, anxiety, and avoidance and escape behaviors.
http://purl.obolibrary.org/obo/HP_0025114	Hypergranulosis	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		Hypergranulosis is an increased thickness of the stratum granulosum.
http://purl.obolibrary.org/obo/HP_0025115	Civatte bodies	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue). They are 10-25 micrometers in diameter and situated mostly within or above the inflammatory cell infiltrate. In lichen planus, the number of necrotic keratinocytes may be so large that they are seen lying in clusters in the uppermost dermis. These bodies show a positive periodic acid Schiff reaction and are diastase resistant
http://purl.obolibrary.org/obo/HP_0025116	Fetal distress	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.
http://purl.obolibrary.org/obo/HP_0025117	Rete ridge flattening	http://purl.obolibrary.org/obo/HP_0034767	Abnormal rete ridge morphology		Rete pegs (or ridges) are the epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes. Rete ridge flattening refers to the loss of these projections so that the skin epithelium acquires a relatively flat appearance.
http://purl.obolibrary.org/obo/HP_0025118	Lip discoloration	http://purl.obolibrary.org/obo/HP_0032453	Abnormal lip pigmentation		Lightening or darkening of the lips from their usual coloring.
http://purl.obolibrary.org/obo/HP_0025119	Violet lip discoloration	http://purl.obolibrary.org/obo/HP_0025118	Lip discoloration		An alteration of the color of the lip to take on a violet color. This term does not include cyanosis.
http://purl.obolibrary.org/obo/HP_0025122	Sawtooth acanthosis	http://purl.obolibrary.org/obo/HP_0025092	Epidermal acanthosis		A type of epidermal acanthosis characterized by a jagged (sawtooth) appearance of the rete ridges of the epidermis.
http://purl.obolibrary.org/obo/HP_0025123	White streaks/specks on enamel	http://purl.obolibrary.org/obo/HP_0011073	Abnormality of dental color		Areas of white discoloration visible on the surface of the teeth (enamel) in the form of streaks or specks.
http://purl.obolibrary.org/obo/HP_0025124	Fragile teeth	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		A tendency of teeth to fracture as manifested by a history of repeated fracture of the dental enamel without adequate trauma.
http://purl.obolibrary.org/obo/HP_0025126	Oral hairy leukoplakia	http://purl.obolibrary.org/obo/HP_5210280	Unusual oral cavity infection		A corrugated white lesion of the oral mucosa that usually occurs on the lateral or ventral surfaces of the tongue and may have a shaggy or frayed appearance.
http://purl.obolibrary.org/obo/HP_0025127	Actinic keratosis	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		A scaly, crusty lesion caused by damage from the ultraviolet radiation of the sun, with typical location on sun-exposed areas of the skin. Actinic keratosis lesions are often elevated, rough, and wartlike, and may be red, or occasionally tan, pink, or flesh-toned in color.
http://purl.obolibrary.org/obo/HP_0025128	Reduced intraabdominal adipose tissue	http://purl.obolibrary.org/obo/HP_0040063	Decreased adipose tissue		An abnormally reduced amount of adipose tissue in the abdominal cavity.
http://purl.obolibrary.org/obo/HP_0025129	Abnormal small intestinal mucosa morphology	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		A structural anomaly of the mucous lining of the small intestine.
http://purl.obolibrary.org/obo/HP_0025130	Decreased small intestinal mucosa lactase level	http://purl.obolibrary.org/obo/HP_0025129	Abnormal small intestinal mucosa morphology		Lactase is produced in the small intestine in humans, Lactase is a member of the beta-galactosidase family of enzymes, and hydrolyzes D-lactose to form D-galactose and D-glucose, which can be absorbed by the small intestine. There are many ways of assessing lactase activity. In one test, an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate, and a color reaction develops within 20 min as a result of hydrolyzed lactose (a positive result) in patients with normolactasia, whereas no reaction (a negative result) develops in patients with severe hypolactasia. Other, less direct, tests include the hydrogen breath test, and blood tests following lactose challenges.
http://purl.obolibrary.org/obo/HP_0025131	Finger swelling	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Enlargement of the soft tissues of one or more fingers.
http://purl.obolibrary.org/obo/HP_0025132	Abnormal circulating estrogen level	http://purl.obolibrary.org/obo/HP_0033799	Abnormal circulating sex hormone concentration		A deviation from normal concentration of the hormone estrogen in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025134	Increased serum estradiol	http://purl.obolibrary.org/obo/HP_0025133	Abnormal serum estradiol		An elevation above normal limits of the concentration of estradiol in the circulation.
http://purl.obolibrary.org/obo/HP_0025135	Abnormal serum estriol	http://purl.obolibrary.org/obo/HP_0025132	Abnormal circulating estrogen level		A deviation from normal concentration of estriol in the circulation.
http://purl.obolibrary.org/obo/HP_0025136	Increased serum estriol	http://purl.obolibrary.org/obo/HP_0025135	Abnormal serum estriol		An elevation above normal limits of estriol concentration in the circulation.
http://purl.obolibrary.org/obo/HP_0025137	Decreased serum estriol	http://purl.obolibrary.org/obo/HP_0025135	Abnormal serum estriol		A reduction below normal limits of estriol in the circulation.
http://purl.obolibrary.org/obo/HP_0025138	Abnormal serum estrone	http://purl.obolibrary.org/obo/HP_0025132	Abnormal circulating estrogen level		A deviation from the normal concentration of circulating estrone.
http://purl.obolibrary.org/obo/HP_0025139	Increased serum estrone	http://purl.obolibrary.org/obo/HP_0025138	Abnormal serum estrone		An elevation above normal limits of the concentration of estrone in the circulation.
http://purl.obolibrary.org/obo/HP_0025140	Decreased serum estrone	http://purl.obolibrary.org/obo/HP_0025138	Abnormal serum estrone		A reduction below normal limits of the concentration of estrone in the circulation.
http://purl.obolibrary.org/obo/HP_0025141	Gingival calcification	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		Ectopic deposition of calcium salts found in the gingiva.
http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.
http://purl.obolibrary.org/obo/HP_0025143	Chills	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A sudden sensation of feeling cold.
http://purl.obolibrary.org/obo/HP_0025144	Shivering	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Involuntary contraction or twitching of the muscles.
http://purl.obolibrary.org/obo/HP_0025145	Rigors	http://purl.obolibrary.org/obo/HP_0025144	Shivering		Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever.
http://purl.obolibrary.org/obo/HP_0025146	Foveal degeneration	http://purl.obolibrary.org/obo/HP_0000608	Macular degeneration		A nonspecific term denoting progressive loss of the retinal pigment epithelium (RPE) and/or neurosensory retinal cells within the fovea.
http://purl.obolibrary.org/obo/HP_0025147	Beaten bronze macular sheen	http://purl.obolibrary.org/obo/HP_0008002	Abnormal macular pigmentation		An irregular grayish appearance of the macula, which is said to resemble beaten bronze or hammered metal.
http://purl.obolibrary.org/obo/HP_0025148	Dark choroid	http://purl.obolibrary.org/obo/HP_0030604	Abnormal fundus fluorescein angiography		A fluorescein angiographic finding of absence of the normal background fluorescence (a dark choroid).
http://purl.obolibrary.org/obo/HP_0025149	Atrophic muscularis propria	http://purl.obolibrary.org/obo/HP_0030935	Abnormal intestinal smooth muscle morphology		Partial or complete wasting (loss) of muscularois propria tissue that was once present. The atrophy may involve a marked vacuolar degeneration of myocytes, loss of muscle fibers and some cases a highly characteristic honeycomb fibrosis.
http://purl.obolibrary.org/obo/HP_0025150	Hypoganglionosis	http://purl.obolibrary.org/obo/HP_0004362	Abnormal enteric ganglion morphology		Sparse and small myenteric ganglia
http://purl.obolibrary.org/obo/HP_0025151	Ganglioneuromatosis	http://purl.obolibrary.org/obo/HP_0004362	Abnormal enteric ganglion morphology		Hyperplastic submucosal and myenteric plexus containing an increased number of ganglion cells, glial cells and nerve fibers.
http://purl.obolibrary.org/obo/HP_0025152	Poor visual behavior for age	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Lack of visual responsiveness or decrease in visual capabilities suggesting a lack of visual responsiveness or decrease in visual capabilities in an infant or young child in which visual behavior fails to meet normal developmental milestones.
http://purl.obolibrary.org/obo/HP_0025153	Transient	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Short-lived and not permanent. This term applies to a phenotypic abnormality that is temporary and of short duration.
http://purl.obolibrary.org/obo/HP_0025154	Portosystemic collateral veins	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Presence of biliary veins that serve as a collateral channel to the systemic circulation
http://purl.obolibrary.org/obo/HP_0025156	Dependency on intravenous nutrition	http://purl.obolibrary.org/obo/HP_0025032	Abnormality of digestive system physiology		Inability to be weaned from intravenous (parenteral) nutrition, as judged by the hydration status (urine output, blood urea nitrogen, creatinine, urine sodium concentration), ability to maintain weight, stool output, and serum electrolyte status.
http://purl.obolibrary.org/obo/HP_0025157	Increased urinary sedoheptulose	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increased concentration of sedoheptulose in the urine. Sedoheptulose is a monosaccharide with seven carbon atoms and a ketone functional group.
http://purl.obolibrary.org/obo/HP_0025158	Hyperautofluorescent retinal lesion	http://purl.obolibrary.org/obo/HP_0030602	Abnormal fundus autofluorescence imaging		Increased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging.
http://purl.obolibrary.org/obo/HP_0025159	Hypoautofluorescent retinal lesion	http://purl.obolibrary.org/obo/HP_0030602	Abnormal fundus autofluorescence imaging		Decreased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging.
http://purl.obolibrary.org/obo/HP_0025160	Abnormal temper tantrums	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		Temper tantrums are brief episodes of extreme, unpleasant, and sometimes aggressive behaviors in response to frustration or anger, which are a normal part of development in toddlers. Temper tantrums that occur more frequently in a given time and/or are more severe in symptomatology and/or longer in duration and/or inappropriate for the given age compared to a temper tantrum that naturally occurs as a part of the developmental process are classified as abnormal temper tantrums.
http://purl.obolibrary.org/obo/HP_0025161	Frequent temper tantrums	http://purl.obolibrary.org/obo/HP_0025160	Abnormal temper tantrums		Temper tantrums that occur more frequently compared to the temper tantrums that are a part of the normal developmental process.
http://purl.obolibrary.org/obo/HP_0025162	Severe temper tantrums	http://purl.obolibrary.org/obo/HP_0025160	Abnormal temper tantrums		Temper tantrums, which occur with more severe symptomatology compared to a temper tantrum that occurs as a part of normal developmental process.
http://purl.obolibrary.org/obo/HP_0025163	Abnormal optic chiasm morphology	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		A structural abnormality of the optic chiasm.The optic chiasm, located below the hypothalamus, is a partial crossing of the optic nerves.
http://purl.obolibrary.org/obo/HP_0025164	Increased number of elastic fibers in the dermis	http://purl.obolibrary.org/obo/HP_0025082	Abnormal cutaneous elastic fiber morphology		An elevated number of elastic fibers, that is of bundles of proteins and glycoproteins in the extracellular matrix in the reticular dermis. Elastic fibers can stretch and recoil back to their original length. This feature can be appreciated on histology with hematoxylin and eosin or other staining methods.
http://purl.obolibrary.org/obo/HP_0025165	Clumping of elastic fibers in the dermis	http://purl.obolibrary.org/obo/HP_0025082	Abnormal cutaneous elastic fiber morphology		Formation of clumps or aggregates that make up small protuberances from elastic fibers within the dermis (especially the reticular dermis).
http://purl.obolibrary.org/obo/HP_0025166	Thickened elastic fibers in the dermis	http://purl.obolibrary.org/obo/HP_0025082	Abnormal cutaneous elastic fiber morphology		An increase of the diameter of elastic fibers in the dermis.
http://purl.obolibrary.org/obo/HP_0025167	Fragmented elastic fibers in the dermis	http://purl.obolibrary.org/obo/HP_0025082	Abnormal cutaneous elastic fiber morphology		Elastic fibers in the dermis exhibit an increased number of breaks associated with disorganization of the structure of the elastic fibers.
http://purl.obolibrary.org/obo/HP_0025168	Left ventricular diastolic dysfunction	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		Abnormal function of the left ventricule during left ventricular relaxation and filling.
http://purl.obolibrary.org/obo/HP_0025169	Left ventricular systolic dysfunction	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		Abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent.
http://purl.obolibrary.org/obo/HP_0025170	Neuronal/glioneuronal neoplasm of the central nervous system	http://purl.obolibrary.org/obo/HP_0100006	Neoplasm of the central nervous system		A central nervous system neoplasm with neuronal and, less consistently, glial differentiation.
http://purl.obolibrary.org/obo/HP_0025171	Rosette-forming glioneuronal tumor	http://purl.obolibrary.org/obo/HP_0025170	Neuronal/glioneuronal neoplasm of the central nervous system		A tumor of the central nervous system that has components of both neurocytic and glial areas, whereby usually the glial component of the tumor predominates. Rossette-forming glioneuronal tumors (RGNT) have biphasic cytoarchitecture with two elements; neurocytic rosettes resembling Homer-Wright rosettes, and astrocytic component resembling a pilocytic astrocytoma. RGNTs are low-grade tumors that lack histopathological signs of malignancy.
http://purl.obolibrary.org/obo/HP_0025172	Smooth septal thickening on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0030879	Interlobular septal thickening		Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a smooth appearance of the interlobular septa.
http://purl.obolibrary.org/obo/HP_0025173	Nodular septal thickening on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0030879	Interlobular septal thickening		Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a nodular or beaded appearance of the interlobular septa.
http://purl.obolibrary.org/obo/HP_0025174	Irregular septal thickening on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0030879	Interlobular septal thickening		Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with an irregular appearance of the interlobular septa. THis feature is often associated with distortion of lung architecture.
http://purl.obolibrary.org/obo/HP_0025175	Honeycomb lung	http://purl.obolibrary.org/obo/HP_0005948	Multiple pulmonary cysts		Honeycombing represents destroyed and fibrotic lung tissue containing numerous cystic airspaces with thick fibrous walls, representing the late stage of various lung diseases, with complete loss of acinar architecture. The cysts range in size from a few millimeters to several centimeters in diameter, have variable wall thickness, and are lined by metaplastic bronchiolar epithelium. On chest radiographs, honeycombing appears as closely approximated ring shadows, typically 3-10 mm in diameter with walls 1-3 mm in thickness, that resemble a honeycomb; the finding implies end-stage lung disease. On CT scans, the appearance is of clustered cystic air spaces, typically of comparable diameters on the order of 3-10 mm but occasionally as large as 2.5 cm. Honeycombing is usually subpleural and is characterized by well-defined walls. It is a CT feature of established pulmonary fibrosis. Because honeycombing is often considered specific for pulmonary fibrosis and is an important criterion in the diagnosis of usual interstitial pneumonia, the term should be used with care, as it may directly impact patient care.
http://purl.obolibrary.org/obo/HP_0025176	Intralobular interstitial thickening	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		A fine reticular pattern on high-resolution computed tomography, with the visible lines separated by a few millimeters. Regions of the lung with intralobular interstitial thickening characteristically show a fine lacelike or netlike appearance.
http://purl.obolibrary.org/obo/HP_0025177	Peribronchovascular interstitial thickening	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Thickening of the peribronchovascular interstitium, a connective tissue sheath that surrounds the central bronchi and pulmonary arteries. The peribronchovascular interstitium extends from the level of the pulmonary hila into the peripheral lung. This feature may be ascertained on high-resolution computer tomography.
http://purl.obolibrary.org/obo/HP_0025178	Subpleural interstitial thickening	http://purl.obolibrary.org/obo/HP_0031630	Abnormal subpleural morphology		Increase in thickness of the subpleural interstitium.
http://purl.obolibrary.org/obo/HP_0025179	Ground-glass opacification	http://purl.obolibrary.org/obo/HP_0031457	Pulmonary opacity		On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which margins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air. Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured.
http://purl.obolibrary.org/obo/HP_0025180	Centrilobular ground-glass opacification on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025179	Ground-glass opacification		A hazy area of increased attenuation in centrilobular areas of the lung with preserved bronchial and vascular markings seen on a computer tomography scan. Centrilobular refers to a location that is central within secondary pulmonary lobules.
http://purl.obolibrary.org/obo/HP_0025181	Abdominal aseptic abscess	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		An abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently.
http://purl.obolibrary.org/obo/HP_0025182	Localized area of pendulous skin	http://purl.obolibrary.org/obo/HP_0008067	Abnormally lax or hyperextensible skin		A confined region of lax skin that hangs below the level of the surrounding skin. Histopatholigically, there is a loss of elastic fibers in the dermis of the affected region.
http://purl.obolibrary.org/obo/HP_0025186	Marcus Gunn jaw winking synkinesis	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Unilateral ptosis with associated upper eyelid contraction and contraction of either the external or the internal pterygoid muscle. It is thought to occur because of congenital miswiring of a branch of the fifth cranial nerve into the branch of the third cranial nerve supplying the levator muscle. In Marcus Gunn jaw winking synkinesis, elevation and even retraction of the affected eyelid is triggered by chewing, suction, lateral mandible movement, smiling, sternocleidomastoid contraction, protruding tongue, Valsalva maneuver and even by breathing.
http://purl.obolibrary.org/obo/HP_0025188	Retinal vasculitis	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		Inflammation of retinal blood vessels as manifested by perivascular sheathing or cuffing, vascular leakage and/or occlusion. It can affect veins, arteries or both.
http://purl.obolibrary.org/obo/HP_0025190	Bilateral tonic-clonic seizure with generalized onset	http://purl.obolibrary.org/obo/HP_0032677	Generalized-onset motor seizure		A bilateral tonic-clonic seizure with generalized onset is a type of bilateral tonic-clonic seizure characterized by generalized onset; these seizures rapidly engage networks in both hemispheres at the start of the seizure.
http://purl.obolibrary.org/obo/HP_0025192	Subtentorial periventricular white matter hyperdensity	http://purl.obolibrary.org/obo/HP_0030891	Periventricular white matter hyperintensities		Areas of brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the fourth cerebral ventricle (which is located beneath the tentorium of the cerebellum).
http://purl.obolibrary.org/obo/HP_0025193	Posterolateral diaphragmatic hernia	http://purl.obolibrary.org/obo/HP_0000776	Congenital diaphragmatic hernia		A posterolateral defect in the diaphragm, commonly referred to as a Bochdalek hernia, which is often accompanied by herniation of the stomach, intestines, liver, and/or spleen into the chest cavity.
http://purl.obolibrary.org/obo/HP_0025194	Morgagni diaphragmatic hernia	http://purl.obolibrary.org/obo/HP_0000776	Congenital diaphragmatic hernia		An anterior retrosternal or parasternal hernia that can result in the herniation of liver or intestines into the chest cavity.
http://purl.obolibrary.org/obo/HP_0025195	Central diaphragmatic hernia	http://purl.obolibrary.org/obo/HP_0000776	Congenital diaphragmatic hernia		A congenital diaphragm defect involving the central tendinous (e.g., amuscular) portion of the diaphragm, whereby the entire rim of diaphragmatic musculature is present.
http://purl.obolibrary.org/obo/HP_0025196	Increased total iron binding capacity	http://purl.obolibrary.org/obo/HP_0033212	Abnormal total iron binding capacity		An elevation in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. A high TIBC corresponds to a high transferrin concentration. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity.
http://purl.obolibrary.org/obo/HP_0025197	Inclusion body fibromatosis	http://purl.obolibrary.org/obo/HP_0012316	Fibrous tissue neoplasm		A benign tumor made up of mostly myofibroblasts that appears almost exclusively on the digits of the hands and feet, rarely involving the thumb or big toe. The lesion displays a proliferation of bland intradermal spindle cells arranged in whorls, fascicles, or a storiform pattern in a collagenous background of varying degrees. Also usually present are perpendicular tumor cell fascicles that extend to the epidermis. The small intracytoplasmic inclusions are said to appear similar to red blood cells. The inclusion bodies have been shown to be made up of densely packed vimentin and actin filaments. The tumor often causes a dome-shaped elevation of the overlying structures, forming a protuberant or polypoid nodule. The overlying epidermis can display a host of changes, including acanthosis, hyperkeratosis, parakeratosis, rete ridge flattening, entrapment of adnexal structures, and, rarely, ulceration.
http://purl.obolibrary.org/obo/HP_0025198	Inflammatory cap polyp	http://purl.obolibrary.org/obo/HP_0005266	Intestinal polyp		A non-malignant sessile or pedunculated polyp in the colon and rectum that displays a cap of inflammatory granulation tissue with fibrinopurulent exudate that covers the polyp.
http://purl.obolibrary.org/obo/HP_0025200	Muscle fiber actin filament accumulation	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		Accumulation in muscle cells of filaments composed of actin.
http://purl.obolibrary.org/obo/HP_0025201	Abnormal circulating apolipoprotein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of apolipoprotein in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025202	Elevated circulating apolipoprotein A-IV concentration	http://purl.obolibrary.org/obo/HP_0033460	Elevated circulating apolipoprotein concentration		The concentration of apolipoprotein A-IV in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025203	Caput medusae	http://purl.obolibrary.org/obo/HP_0030168	Dilated superficial abdominal veins		Distended and engorged umbilical veins which are seen radiating from the umbilicus across the abdomen to join systemic veins.
http://purl.obolibrary.org/obo/HP_0025204	Triggered by	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		A trigger is defined as an external factor that leads to the manifestation of a sign or symptom in a person with a susceptibility to developing that manifestation.
http://purl.obolibrary.org/obo/HP_0025205	Triggered by breast feeding	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by breast feeding in an infant.
http://purl.obolibrary.org/obo/HP_0025206	Triggered by cold	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure to cold surroundings.
http://purl.obolibrary.org/obo/HP_0025207	Triggered by dehydration	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by being dehydrated, i.e., by a deficit in total body water.
http://purl.obolibrary.org/obo/HP_0025208	Triggered by carbohydrate ingestion	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by eating or drinking carbohydrates.
http://purl.obolibrary.org/obo/HP_0025209	Triggered by fructose ingestion	http://purl.obolibrary.org/obo/HP_0025208	Triggered by carbohydrate ingestion		Applies to a sign or symptom that is provoked or brought about by eating or drinking fructose.
http://purl.obolibrary.org/obo/HP_0025210	Triggered by glucose ingestion	http://purl.obolibrary.org/obo/HP_0025208	Triggered by carbohydrate ingestion		Applies to a sign or symptom that is provoked or brought about by eating or drinking glucose.
http://purl.obolibrary.org/obo/HP_0025211	Triggered by ethanol ingestion	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by drinking or otherwise ingesting ethanol.
http://purl.obolibrary.org/obo/HP_0025212	Triggered by fasting	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by abstaining from eating food (fasting).
http://purl.obolibrary.org/obo/HP_0025213	Triggered by galactose ingestion	http://purl.obolibrary.org/obo/HP_0025208	Triggered by carbohydrate ingestion		Applies to a sign or symptom that is provoked or brought about by eating or drinking galactose. Galactose usually is ingested as lactose, which is composed of equimolar amounts of glucose and galactose.
http://purl.obolibrary.org/obo/HP_0025214	Triggered by heat	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure to heat.
http://purl.obolibrary.org/obo/HP_0025215	Triggered by febrile illness	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by febrile illness.
http://purl.obolibrary.org/obo/HP_0025216	Triggered by heavy meal	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by eating large quantities of food, for instance, by a heavy meal.
http://purl.obolibrary.org/obo/HP_0025217	Triggered by high-fat diet	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by eating a diet high in lipids.
http://purl.obolibrary.org/obo/HP_0025218	Triggered by hyperventilation	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by excessively rapid and deep breathing.
http://purl.obolibrary.org/obo/HP_0025219	Triggered by vaccination	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by a vaccination.
http://purl.obolibrary.org/obo/HP_0025220	Triggered by menstruation	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by menstruation in a female.
http://purl.obolibrary.org/obo/HP_0025221	Triggered by pregnancy	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by pregnancy in a female.
http://purl.obolibrary.org/obo/HP_0025222	Triggered by sleep deprivation	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by a lack of sufficient sleep.
http://purl.obolibrary.org/obo/HP_0025223	Triggered by smoking	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by smoking.
http://purl.obolibrary.org/obo/HP_0025224	Triggered by sodium ingestion	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by eating or drinking sodium.
http://purl.obolibrary.org/obo/HP_0025225	Triggered by sound	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure to sound or noise.
http://purl.obolibrary.org/obo/HP_0025226	Triggered by stress	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by a physical, mental, or emotional factor associated with bodily or mental tension.
http://purl.obolibrary.org/obo/HP_0025227	Triggered by excitement	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by a a state of excitement or by being startled.
http://purl.obolibrary.org/obo/HP_0025228	Triggered by sudden movement	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by a sudden movement.
http://purl.obolibrary.org/obo/HP_0025229	Triggered by vestibular stimulation	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by vestibular stimulation, including head turning, cold calorics, postural changes, or rotating chair.
http://purl.obolibrary.org/obo/HP_0025230	Tendonitis	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		Inflammation of a tendon.
http://purl.obolibrary.org/obo/HP_0025231	Abnormal synovial bursa morphology	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		A structural anomaly of a synovial bursa, which is a synovium-lined, sac-like structure found throughout the body near bony prominences and between bones, muscles, tendons, and ligaments. The bursa itself is a synovial lining that represents a potential space insofar as it is collapsed upon itself until a resulting trigger causes the bursa to become irritated and fill with synovial fluid.
http://purl.obolibrary.org/obo/HP_0025232	Bursitis	http://purl.obolibrary.org/obo/HP_0025231	Abnormal synovial bursa morphology		Inflammation of a synovial bursa.
http://purl.obolibrary.org/obo/HP_0025233	Sleep paralysis	http://purl.obolibrary.org/obo/HP_5200293	Sleep-wake transition abnormality		Inability to move trunk and limbs and inability to speak during transition into or out of sleep; awareness is preserved and recall is present.
http://purl.obolibrary.org/obo/HP_0025234	Parasomnia	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		A clinically observable or self-reported abnormal behavior, experience, or physiological event that occurs in association with sleep, specific sleep stages, or sleep-wake transitions.
http://purl.obolibrary.org/obo/HP_0025235	NREM parasomnia	http://purl.obolibrary.org/obo/HP_0025234	Parasomnia		A parasomnia that occurs during non-rapid eye movement (NREM) sleep.
http://purl.obolibrary.org/obo/HP_0025236	Sleep walking	http://purl.obolibrary.org/obo/HP_0025235	NREM parasomnia		Ambulation during sleep with lack awareness and limited or no recall of the event.
http://purl.obolibrary.org/obo/HP_0025238	Foot pain	http://purl.obolibrary.org/obo/HP_0012514	Lower limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the foot.
http://purl.obolibrary.org/obo/HP_0025240	Preretinal hemorrhage	http://purl.obolibrary.org/obo/HP_0031803	Fundus hemorrhage		An accumulation of blood that is located between the retina and the detached posterior hyaloid, or in the vitreous cavity. Subhyaloid premacular hemorrhage is typically characterized by a circumscribed, round or dumb-bell shaped, bright red mound of blood beneath the internal limiting membrane (ILM) or between the ILM and hyaloid face, in or near to the central macular area.
http://purl.obolibrary.org/obo/HP_0025241	Flame-shaped retinal hemorrhage	http://purl.obolibrary.org/obo/HP_0031805	Intraretinal hemorrhage		A type of retinal hemorrhage that is located within the nerve fiber layer (NFL) of the retina and that exhibits a characteristic flame shape which results from constraints by the structure of the NFL (axons of the ganglion cells).
http://purl.obolibrary.org/obo/HP_0025242	Dot-and-blot retinal hemorrhage	http://purl.obolibrary.org/obo/HP_0031805	Intraretinal hemorrhage		Accumulation of blood located in the retina's inner nuclear and outer plexiform layers, and having a dot-like or blot-like shape. THe shape results from intraretinal compression, restricting the hemorrhages within a specific location.
http://purl.obolibrary.org/obo/HP_0025243	Subretinal hemorrhage	http://purl.obolibrary.org/obo/HP_0000573	Retinal hemorrhage		Accumulation of blood located beneath the neurosensory retina in the space between the neurosensory retina and the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0025244	Sub-retinal pigment epithelium haemorrhage	http://purl.obolibrary.org/obo/HP_0000573	Retinal hemorrhage		An accumulation of blood located between the retinal pigment epithelium (RPE) and Bruch membrane.
http://purl.obolibrary.org/obo/HP_0025245	Cutaneous cyst	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A hollow mass located in the skin that is surrounded by an epithelium-lined wall and is well demarcated from the adjacent tissue. Cysts are often said to be sac-like and may contain serous liquid or semisolid material.
http://purl.obolibrary.org/obo/HP_0025246	Trichilemmal cyst	http://purl.obolibrary.org/obo/HP_0025245	Cutaneous cyst		Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Trichilemmal cysts are acquired rather than congenital, and tend to appear on the scalp rather than the face, and to be intradermal rather than subcutaneous.
http://purl.obolibrary.org/obo/HP_0025247	Dermoid cyst	http://purl.obolibrary.org/obo/HP_0025245	Cutaneous cyst		A congenital subcutaneous cyst that arises from entrapment of skin along the lines of embryonic fusion. In contrast to epidermal cysts, dermoid cysts tend to contain various adnexal structures such as hair, sebaceous, eccrine or apocrine glands. Dermoid cysts are present at birth, and are indolent, firm, deep, subcutaneous nodules. They are often located on the head and neck, and rarely in the anogenital area. Dermoid cysts are slowly progressive and can grow to a size of 1 to 4 cm.
http://purl.obolibrary.org/obo/HP_0025248	Eruptive vellus hair cyst	http://purl.obolibrary.org/obo/HP_0025245	Cutaneous cyst		A cutaneous cyst that is small (one or two millimeters in diameter) and painless, presenting as a follicular papule that usually is skin colored but may have a reddish or brownish tinge.
http://purl.obolibrary.org/obo/HP_0025249	Comedo	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A clogged cutaneous sebaceous follicle, which is a cutaneous gland that secretes sebum (usually into a hair follicle).
http://purl.obolibrary.org/obo/HP_0025250	Closed comedo	http://purl.obolibrary.org/obo/HP_0025249	Comedo		A comedo in which the top of the pore is not stretched open and thus does not expose the clogged portion (which would appear black), hence the name whitehead.
http://purl.obolibrary.org/obo/HP_0025251	Open comedo	http://purl.obolibrary.org/obo/HP_0025249	Comedo		A comedo in which the part of the pore at the surface of the skin is stretched and open, exposing the contents of the comedo, which appear black.
http://purl.obolibrary.org/obo/HP_0025252	Geographic tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		An anomaly of the tongue characterized by loss (atrophy) of filiform papillae of the tongue, leaving areas of erythema (redness), surrounded by a serpiginous, white, hyperkeratotic border. The name geographic tongue refers to an appearance that is said to be similar to a map.
http://purl.obolibrary.org/obo/HP_0025253	Claustrophobia	http://purl.obolibrary.org/obo/HP_5200232	Phobia		An abnormal fear of being in a closed or narrow space with no escape is called claustrophobia.
http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		An ameliorating factor is defined as an external factor that leads to a sign or symptom that is already present improving or becoming more bearable
http://purl.obolibrary.org/obo/HP_0025255	Ameliorated by pregnancy	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by pregnancy in a female.
http://purl.obolibrary.org/obo/HP_0025256	Ameliorated by heat	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by heat (including fever).
http://purl.obolibrary.org/obo/HP_0025257	Ameliorated by carbohydrate ingestion	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by eating or drinking carbohydrates including glucose (sugar).
http://purl.obolibrary.org/obo/HP_0025258	Stiff neck	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in the neck when attempting to move it, especially after a period of inactivity. Neck stiffness often involves soreness and difficulty moving the neck, especially when trying to turn the head to the side.
http://purl.obolibrary.org/obo/HP_0025259	Stiff elbow	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in the elbow joint when attempting to move it, especially after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0025260	Stiff wrist	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in the wrist joint when attempting to move it, especially after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0025261	Stiff finger	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in a finger joint when attempting to move it, especially after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0025262	Stiff hip	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in the hip joint when attempting to move it, especially after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0025263	Stiff knee	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in the knee joint when attempting to move it, especially after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0025264	Stiff ankle	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in the ankle joint when attempting to move it, especially after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0025265	Stiff toe	http://purl.obolibrary.org/obo/HP_0001387	Joint stiffness		A sensation of tightness in a toe joint when attempting to move it, especially after a period of inactivity.
http://purl.obolibrary.org/obo/HP_0025267	Snoring	http://purl.obolibrary.org/obo/HP_5200283	Sleep-related breathing disorders		Deep, noisy breathing during sleep, accompanied by hoarse or harsh sounds, is caused by the vibration of respiratory structures, especially the soft palate. This vibration results in sound due to obstructed air movement during breathing while sleeping.
http://purl.obolibrary.org/obo/HP_0025268	Stuttering	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		Disruptions in the production of speech sounds, with involuntary repetitions of words or parts of words, prolongations of speech sounds, or complete blockage of speech production for several seconds.
http://purl.obolibrary.org/obo/HP_0025269	Panic attack	http://purl.obolibrary.org/obo/HP_0000739	Anxiety		A sudden episode of intense fear in a situation where there is no danger or apparent cause.
http://purl.obolibrary.org/obo/HP_0025271	Esophageal spasms	http://purl.obolibrary.org/obo/HP_0025270	Abnormal esophagus physiology		Involuntary contractions of the esophagus that are irregular, uncoordinated, and painful.
http://purl.obolibrary.org/obo/HP_0025272	Melasma	http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin		Symmetrical, blotchy, brownish facial pigmentation.
http://purl.obolibrary.org/obo/HP_0025273	Achilles tendonitis	http://purl.obolibrary.org/obo/HP_0025230	Tendonitis		Inflammation of the Achilles tendon.
http://purl.obolibrary.org/obo/HP_0025274	Ovarian dermoid cyst	http://purl.obolibrary.org/obo/HP_0012226	Ovarian teratoma		An cystic ovarian teratoma composed of dermal and epidermal elements and containing tissue components including hair, teeth, bone, thyroid, and others.
http://purl.obolibrary.org/obo/HP_0025275	Lateral	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that is located farther from the median plane or midline of the body or of the referenced structure.
http://purl.obolibrary.org/obo/HP_0025277	Gustatory sweating	http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology		Hyperhidrosis that occurs with gustatory stimulation (e.g., moisture on face from sweating that occurs after eating).
http://purl.obolibrary.org/obo/HP_0025278	Cold-induced sweating	http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology		Sweating provoked by cold temperature rather than by heat.
http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		A pain characteristic is defined as a subjective category or type of pain.
http://purl.obolibrary.org/obo/HP_0025281	Sharp	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Applied to pain that is described as sharp, i.e., sudden and severe.
http://purl.obolibrary.org/obo/HP_0025282	Dull	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Applied to pain that is dull, i.e., not severe but that continues over a long period of time.
http://purl.obolibrary.org/obo/HP_0025283	Tender	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Applied to pain that is tender, i.e., elicited by touching the affected body part.
http://purl.obolibrary.org/obo/HP_0025284	Sleep-interrupting	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Applied to pain that wakes the affecting individual from sleep.
http://purl.obolibrary.org/obo/HP_0025285	Aggravated by	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		An aggravating factor is defined as an external factor that leads to a sign or symptom that is already present getting worse or becoming more severe.
http://purl.obolibrary.org/obo/HP_0025286	Aggravated by activity	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is aggravated by activity, exertion, or exercise.
http://purl.obolibrary.org/obo/HP_0025287	Axial	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that is situated in the central part of the body, in the head and trunk as distinguished from the limbs.
http://purl.obolibrary.org/obo/HP_0025289	Cervical lymphadenopathy	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Enlarged lymph nodes in the neck.
http://purl.obolibrary.org/obo/HP_0025290	Upper-body predominance	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that affects the arms, trunk, head more than the legs.
http://purl.obolibrary.org/obo/HP_0025291	Lower-body predominance	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that affects the legs more than the arms, trunk, head.
http://purl.obolibrary.org/obo/HP_0025292	Acral	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that affects the distal portions of limbs (hand, foot) and head (ears, nose).
http://purl.obolibrary.org/obo/HP_0025293	Distributed along Blaschko lines	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose localization corresponds to the lines of Blaschko, which correspond to the lineage of epithelia cells. Blaschko lines are normally invisible but may become apparent with certain skin diseases and then can be seen to be distributed in lines horizontal to the body.
http://purl.obolibrary.org/obo/HP_0025294	Dermatomal	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose localization corresponds to the dermatomes, i.e., the nerve root distribution.
http://purl.obolibrary.org/obo/HP_0025295	Herpetiform	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance resembles that of the grouped umbilicated vesicles seen in herpes simplex and herpes zoster infections.
http://purl.obolibrary.org/obo/HP_0025296	Morbilliform	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance resembles that of measles, i.e., maculopapular lesions that are red and roughly 2 to 10 mm in diameter and may be partially confluent.
http://purl.obolibrary.org/obo/HP_0025297	Prolonged	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Applied to an abnormality whose duration is extended over a longer period of time than is expected or usual (e.g., prolonged fever lasts longer than one usually sees with an infection).
http://purl.obolibrary.org/obo/HP_0025300	Malar rash	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		An erythematous (red), flat facial rash that affects the skin in the malar area (over the cheekbones) and extends over the bridge of the nose.
http://purl.obolibrary.org/obo/HP_0025301	Nocturnal	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Applies to an abnormality that occurs in or is exacerbated during the night.
http://purl.obolibrary.org/obo/HP_0025302	Diurnal	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Applies to a sign, symptom, or other abnormality that occurs in or is exacerbated in the day time.
http://purl.obolibrary.org/obo/HP_0025303	Episodic	http://purl.obolibrary.org/obo/HP_0031796	Recurrent		Applied to a sign, symptom, or other manifestation that occurs multiple times at usually irregular intervals. The occurrences are separated by an interval in which the sign, symptom, or manifestation is not present.
http://purl.obolibrary.org/obo/HP_0025304	Periodic	http://purl.obolibrary.org/obo/HP_0031796	Recurrent		Applies to a sign, symptom, or other manifestation that recurs with a fixed time interval, i.e., the symptom-free periods are always of the same length.
http://purl.obolibrary.org/obo/HP_0025305	Quotidian	http://purl.obolibrary.org/obo/HP_0025304	Periodic		Applies to a sign, symptom, or other manifestation that is episodic with a fixed time interval of one day (24 hours).
http://purl.obolibrary.org/obo/HP_0025306	Acute emergence over minutes	http://purl.obolibrary.org/obo/HP_0011009	Acute		Acute appearance of disease manifestations in a period of minutes.
http://purl.obolibrary.org/obo/HP_0025307	Acute emergence over hours	http://purl.obolibrary.org/obo/HP_0011009	Acute		Acute appearance of disease manifestations in a period of hours.
http://purl.obolibrary.org/obo/HP_0025308	Acute emergence over days	http://purl.obolibrary.org/obo/HP_0011009	Acute		Acute appearance of disease manifestations in a period of days.
http://purl.obolibrary.org/obo/HP_0025309	Abnormal pupil shape	http://purl.obolibrary.org/obo/HP_0000615	Abnormal pupil morphology		A deviation from the normal circular shape of the pupil
http://purl.obolibrary.org/obo/HP_0025310	Oval pupil	http://purl.obolibrary.org/obo/HP_0025309	Abnormal pupil shape		An abnormal pupil shape that is elliptical, i.e., egg-like.
http://purl.obolibrary.org/obo/HP_0025311	Anterior chamber cyst	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		A closed sac, having a distinct membrane and division compared to the nearby tissue located within the anterior chamber. The sac that may contain air, fluids, or semi-solid material.
http://purl.obolibrary.org/obo/HP_0025312	Esophoria	http://purl.obolibrary.org/obo/HP_0032011	Heterophoria		A form of strabismus with both eyes turned inward to a relatively mild degree, usually defined as less than 10 prism diopters.
http://purl.obolibrary.org/obo/HP_0025313	Exophoria	http://purl.obolibrary.org/obo/HP_0032011	Heterophoria		A form of strabismus with one or both eyes deviated outward to a milder degree than with exotropia.
http://purl.obolibrary.org/obo/HP_0025314	Choroidal nevus	http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology		A benign, flat or slightly elevated melanocytic lesions of the posterior uvea with clearly defined margins. Choroidal nevi tend to remain stable in size, and to display features such as overlying drusen as well as retinal pigment epithelial atrophy, hyperplasia or fibrous metaplasia.
http://purl.obolibrary.org/obo/HP_0025315	Exacerbated by head trauma	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applies to a sign or symptom that is worsened, aggravated, or exacerbated by head trauma.
http://purl.obolibrary.org/obo/HP_0025317	Cubitus varus	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		A deformity of the elbow in which there is a deviation of the forearm toward the midline of the body.
http://purl.obolibrary.org/obo/HP_0030000	EMG: repetitive nerve stimulation abnormality	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		Abnormality observed upon electromyography when nerve studied is electrically stimulated six to ten times at 2 or 3 Hertz.
http://purl.obolibrary.org/obo/HP_0030001	Lagophthalmos	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		A condition in which the eyelids do not close to cover the eye completely.
http://purl.obolibrary.org/obo/HP_0030002	Nocturnal lagophthalmos	http://purl.obolibrary.org/obo/HP_0030001	Lagophthalmos		The inability to close the eyelids during sleep.
http://purl.obolibrary.org/obo/HP_0030003	Paralytic lagophthalmos	http://purl.obolibrary.org/obo/HP_0030001	Lagophthalmos		A type of lagophthalmos that occurs in association with facial nerve palsy.
http://purl.obolibrary.org/obo/HP_0030004	Cicatricial lagophthalmos	http://purl.obolibrary.org/obo/HP_0030001	Lagophthalmos		A type of lagophthalmos that occurs following trauma or surgery.
http://purl.obolibrary.org/obo/HP_0030005	Capillary leak	http://purl.obolibrary.org/obo/HP_0025018	Abnormal capillary physiology		An acute phenomenon characterized by hypotension and anasarca due to the loss of plasma volume into peripheral tissues, with evidence of decreased plasma volume (hemoconcentration) and protein loss from the intravascular space (hypoalbuminemia) during acute episodes.
http://purl.obolibrary.org/obo/HP_0030006	Single fiber EMG abnormality	http://purl.obolibrary.org/obo/HP_0003457	EMG abnormality		Abnormality in single fiber EMG recording, a technique that allows identification of action potentials (APs) from individual muscle fibers.
http://purl.obolibrary.org/obo/HP_0030007	EMG: positive sharp waves	http://purl.obolibrary.org/obo/HP_0003482	EMG: axonal abnormality		These are spontaneous firing action potentials stimulated by needle movement of an injured muscle fiber. There is propagation to, but not past, the needle tip. This inhibits the display of the negative deflection of the waveform.
http://purl.obolibrary.org/obo/HP_0030008	Cervical agenesis	http://purl.obolibrary.org/obo/HP_0430114	Aplasia/hypoplasia of the uterine cervix		Congenital absence of the uterine cervix.
http://purl.obolibrary.org/obo/HP_0030009	Cervical insufficiency	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		A cervix that shows a painless dilation and shortening during the second trimester of pregnancy with resultant recurrent pregnancy loss or delivery is considered incompetent
http://purl.obolibrary.org/obo/HP_0030010	Hydrometrocolpos	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		Hydrometrocolpos is an accumulation of uterine and vaginal secretions as well as menstrual blood in the uterus and vagina.
http://purl.obolibrary.org/obo/HP_0030011	Imperforate hymen	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		A congenital disorder where the hymen (a membrane that surrounds or partially covers the external vaginal opening) does not have an opening and completely obstructs the vagina.
http://purl.obolibrary.org/obo/HP_0030014	Female sexual dysfunction	http://purl.obolibrary.org/obo/HP_0030012	Abnormal female reproductive system physiology		A problem occurring during any phase of the female sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity
http://purl.obolibrary.org/obo/HP_0030015	Female anorgasmia	http://purl.obolibrary.org/obo/HP_0046502	Anorgasmia		The persistent of recurrent difficulty, delay in, or absence of attaining orgasm following sufficient sexual stimulation and arousal.
http://purl.obolibrary.org/obo/HP_0030016	Dyspareunia	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of reproductive system physiology		Recurrent or persistent genital pain associated with sexual intercourse.
http://purl.obolibrary.org/obo/HP_0030017	Vaginismus	http://purl.obolibrary.org/obo/HP_0030014	Female sexual dysfunction		Recurrent or persistent involuntary spasms of the musculature of the outer third of the vagina that interferes with vaginal penetration, and which causes personal distress.
http://purl.obolibrary.org/obo/HP_0030018	Decreased female libido	http://purl.obolibrary.org/obo/HP_0046504	Decreased libido		Diminished sexual desire in female.
http://purl.obolibrary.org/obo/HP_0030019	Increased female libido	http://purl.obolibrary.org/obo/HP_0046503	Increased libido		Elevated sexual desire in female
http://purl.obolibrary.org/obo/HP_0030021	Auricular tag	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Small protrusion within the pinna.
http://purl.obolibrary.org/obo/HP_0030022	Question mark ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Cleft between the helix and the lobe.
http://purl.obolibrary.org/obo/HP_0030023	Quelprud nodule	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Small cartilaginous prominence on the posterior concha.
http://purl.obolibrary.org/obo/HP_0030024	Pretragal ectopia	http://purl.obolibrary.org/obo/HP_0000383	Abnormal periauricular region morphology		Variably shaped, cartilage-containing tissue anterior to the external auditory meatus.
http://purl.obolibrary.org/obo/HP_0030025	Auricular pit	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Small indentation in the lower part of the ascending helix, concha, or in the crus helix.
http://purl.obolibrary.org/obo/HP_0030026	Squared superior portion of helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		Flattening instead of curving or rounded superior helix, allowing the superior helix to run more horizontally than usual.
http://purl.obolibrary.org/obo/HP_0030027	Abnormal nasal cartilage morphology	http://purl.obolibrary.org/obo/HP_0010938	Abnormal external nose morphology		A morphological anomaly of the nasal cartilage.
http://purl.obolibrary.org/obo/HP_0030028	Absent nasal cartilage	http://purl.obolibrary.org/obo/HP_0030027	Abnormal nasal cartilage morphology		Lack of a palpable nasal cartilage.
http://purl.obolibrary.org/obo/HP_0030029	Splayed fingers	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Divergence of digits along the A/P axis (in the plane of the palm).
http://purl.obolibrary.org/obo/HP_0030030	Absent ray	http://purl.obolibrary.org/obo/HP_0002813	Abnormal limb bone morphology		The absence of all phalanges of a digit and the associated metacarpal /metatarsal.
http://purl.obolibrary.org/obo/HP_0030031	Small toe	http://purl.obolibrary.org/obo/HP_0001991	Aplasia/Hypoplasia of toe		Significant reduction in both length and girth of the toe compared to the contralateral toe, or alternatively, compared to a typical toe size for an age-matched individual.
http://purl.obolibrary.org/obo/HP_0030032	Partial absence of foot	http://purl.obolibrary.org/obo/HP_0006494	Aplasia/Hypoplasia involving bones of the feet		An incomplete absence of the foot, with no bony elements distal to the tarsals, but with preservation of some or all of the tarsals.
http://purl.obolibrary.org/obo/HP_0030033	Small finger	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		Significant reduction in both length and girth of the finger compared to the contralateral finger, or alternatively, compared to a typical finger size for an age-matched individual.
http://purl.obolibrary.org/obo/HP_0030034	Glomerular basement membrane lamellation	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Presence of abnormal additional layers of the basement membrane of the glomerulus.
http://purl.obolibrary.org/obo/HP_0030035	Struvite nephrolithiasis	http://purl.obolibrary.org/obo/HP_0000787	Kidney stone		Presence of struvite (magnesium ammonium phosphate) containing calculi (kidney stones).
http://purl.obolibrary.org/obo/HP_0030036	Isothenuria	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		Inability of the kidneys to produce either concentrated or dilute urine.
http://purl.obolibrary.org/obo/HP_0030037	Bifid ureter	http://purl.obolibrary.org/obo/HP_0000073	Ureteral duplication		Incomplete duplication of the ureter.
http://purl.obolibrary.org/obo/HP_0030039	Fused thoracic vertebrae	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		A congenital anomaly characterized by a joining (fusion) of two or more thoracic vertebral bodies with one another.
http://purl.obolibrary.org/obo/HP_0030040	Fused lumbar vertebrae	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		A congenital anomaly characterized by a joining (fusion) of two or more lumbar vertebral bodies with one another.
http://purl.obolibrary.org/obo/HP_0030041	Schmorl's node	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		A Schmorl's node is the herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of the adjacent vertebra.
http://purl.obolibrary.org/obo/HP_0030042	Incomplete ossification of pubis	http://purl.obolibrary.org/obo/HP_0009105	Abnormal ossification of the pubic bone		Failure to complete ossification (maturation and calcification) of the pubic bone.
http://purl.obolibrary.org/obo/HP_0030043	Hip subluxation	http://purl.obolibrary.org/obo/HP_0001384	Abnormal hip joint morphology		A partial dislocation of the hip joint, whereby the head of the femur is partially displaced from the socket.
http://purl.obolibrary.org/obo/HP_0030045	Serpentine fibula	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		Elongated curved (S-shaped) fibulae.
http://purl.obolibrary.org/obo/HP_0030046	Hypoglycosylation of alpha-dystroglycan	http://purl.obolibrary.org/obo/HP_0030112	Abnormal muscle fiber alpha dystroglycan		A reduction in the degree of glycosylation of alpha-dystroglycan in muscle tissue.
http://purl.obolibrary.org/obo/HP_0030048	Colpocephaly	http://purl.obolibrary.org/obo/HP_0030047	Abnormal lateral ventricle morphology		Colpocephaly is an anatomic finding in the brain manifested by occipital horns that are disproportionately enlarged in comparison with other parts of the lateral ventricles.
http://purl.obolibrary.org/obo/HP_0030049	Brain abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A collection of pus, immune cells, and other material in the brain.
http://purl.obolibrary.org/obo/HP_0030051	Tip-toe gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		An abnormal gait pattern characterized by the failure of the heel to contact the floor at the onset of stance during gait.
http://purl.obolibrary.org/obo/HP_0030052	Inguinal freckling	http://purl.obolibrary.org/obo/HP_0001480	Freckling		The presence in the inguinal region (groin) of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin.
http://purl.obolibrary.org/obo/HP_0030053	Stiff skin	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		An induration (hardening) of the skin
http://purl.obolibrary.org/obo/HP_0030054	Perifollicular fibrosis	http://purl.obolibrary.org/obo/HP_0031285	Abnormal perifollicular morphology		Presence of excess fibrous connective tissue surrounding hair follicules.
http://purl.obolibrary.org/obo/HP_0030055	Hyperconvex toenail	http://purl.obolibrary.org/obo/HP_0001795	Hyperconvex nail		When viewed on end (with the tip of the toe pointing toward the examiner's eye) the curve of the toenail forms a tighter curve of convexity.
http://purl.obolibrary.org/obo/HP_0030056	Uncombable hair	http://purl.obolibrary.org/obo/HP_0010719	Abnormality of hair texture		Hair that is disorderly, stands out from the scalp, and cannot be combed flat.
http://purl.obolibrary.org/obo/HP_0030058	Sickled erythrocytes	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains).
http://purl.obolibrary.org/obo/HP_0030059	Mitochondrial depletion	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		An abnormal reduction in mitochondrial DNA content of cells.
http://purl.obolibrary.org/obo/HP_0030060	Nervous tissue neoplasm	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		A neoplasm derived from nervous tissue (not necessarily a neoplasm located in the nervous system).
http://purl.obolibrary.org/obo/HP_0030061	Neuroectodermal neoplasm	http://purl.obolibrary.org/obo/HP_0030060	Nervous tissue neoplasm		A neoplasm arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.
http://purl.obolibrary.org/obo/HP_0030062	Craniopharyngioma	http://purl.obolibrary.org/obo/HP_0030061	Neuroectodermal neoplasm		A benign pituitary-region neoplasm that originates from Rathke's pouch. Craniopharyngiomas are benign slow growing tumors that are located within the sellar and para sellar region of the central nervous system.
http://purl.obolibrary.org/obo/HP_0030064	Neurocytoma	http://purl.obolibrary.org/obo/HP_0030063	Neuroepithelial neoplasm		A benign brain tumor composed of neural elements which most often arise from the septum pellucidum and the walls of the lateral ventricles.
http://purl.obolibrary.org/obo/HP_0030065	Primitive neuroectodermal tumor	http://purl.obolibrary.org/obo/HP_0030063	Neuroepithelial neoplasm		A tumor that originates in cells from the primitive neural crest. This group of tumors is characteirzed by the presence of primitive cells with elements of neuronal and/or glial differentiation.
http://purl.obolibrary.org/obo/HP_0030066	Ependymoblastoma	http://purl.obolibrary.org/obo/HP_0030070	Central primitive neuroectodermal tumor		A highly malignant embryonal tumor of infancy and young childhood characterized by neuroectodermal elements organized in distinctive multilayered rosettes. Ependymoblastomas are large lesions that occur in the supratentorial compartment, typically displaying a physical connection to the ventricular system.
http://purl.obolibrary.org/obo/HP_0030068	Olfactory esthesioneuroblastoma	http://purl.obolibrary.org/obo/HP_0003006	Neuroblastoma		A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate.
http://purl.obolibrary.org/obo/HP_0030069	Primary central nervous system lymphoma	http://purl.obolibrary.org/obo/HP_0012539	Non-Hodgkin lymphoma		A form of extranodal, high-grade non-Hodgkin B-cell neoplasm, usually large cell or immunoblastic type that originates in the brain, leptomeninges, spinal cord, or eyes and typically remains confined to the CNS.
http://purl.obolibrary.org/obo/HP_0030070	Central primitive neuroectodermal tumor	http://purl.obolibrary.org/obo/HP_0030065	Primitive neuroectodermal tumor		A primitive neuroectodermal neoplasm that occurs in the central nervous system.
http://purl.obolibrary.org/obo/HP_0030071	Medulloepithelioma	http://purl.obolibrary.org/obo/HP_0030070	Central primitive neuroectodermal tumor		A primitive neuroectodermal tumor that originates from the cells of the embryonic medullary canal.
http://purl.obolibrary.org/obo/HP_0030072	Paranasal sinus neoplasm	http://purl.obolibrary.org/obo/HP_0012720	Neoplasm of the nose		A tumor that originates in the paranasal sinus.
http://purl.obolibrary.org/obo/HP_0030074	Chemodectoma	http://purl.obolibrary.org/obo/HP_0002668	Paraganglioma		A usually benign neoplasm originating in the chemoreceptor tissue of the carotid body, glomus jugulare, glomus tympanicum, aortic bodies, or the female genital tract.
http://purl.obolibrary.org/obo/HP_0030075	Ductal carcinoma in situ	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		Presence of abnormal cells inside a milk duct, that is, non-invasive breast cancer. Ductal carcinoma in situ is considered to be a precursor lesion to invasive breast cancer.
http://purl.obolibrary.org/obo/HP_0030077	Bronchial neoplasm	http://purl.obolibrary.org/obo/HP_0100552	Neoplasm of the tracheobronchial system		A tumor originating in a bronchus.
http://purl.obolibrary.org/obo/HP_0030079	Cervix cancer	http://purl.obolibrary.org/obo/HP_0032241	Cervical neoplasm		A tumor of the uterine cervix.
http://purl.obolibrary.org/obo/HP_0030080	Burkitt lymphoma	http://purl.obolibrary.org/obo/HP_0012539	Non-Hodgkin lymphoma		A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass.
http://purl.obolibrary.org/obo/HP_0030081	Punctate periventricular T2 hyperintense foci	http://purl.obolibrary.org/obo/HP_0030891	Periventricular white matter hyperintensities		Multiple pointlike areas of high T2 signal observed upon magnetic resonance imaging of the periventricular cerebral white matter.
http://purl.obolibrary.org/obo/HP_0030083	Salt craving	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		Hypersalivation, also known as salt craving, refers to an excessive desire to consume salt (sodium chloride) or salty foods.
http://purl.obolibrary.org/obo/HP_0030086	Reduced CSF lactate	http://purl.obolibrary.org/obo/HP_0030085	Abnormal CSF lactate concentration		Decreased concentration of lactate in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0030087	Abnormal circulating testosterone concentration	http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level		An anomalous concentration of testosterone in the blood.
http://purl.obolibrary.org/obo/HP_0030088	Increased serum testosterone level	http://purl.obolibrary.org/obo/HP_0030348	Increased circulating androgen concentration		An elevated circulating testosterone level in the blood.
http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		An anomalous amount of protein present in or on the surface of muscle fibers. This feature may be appreciate upon immunohistochemical investigation of muscle biopsy tissue.
http://purl.obolibrary.org/obo/HP_0030090	Abnormal muscle fiber merosin expression	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		An anomalous amount of merosin in muscle fibers. Merosin is a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve.
http://purl.obolibrary.org/obo/HP_0030091	Absent muscle fiber merosin	http://purl.obolibrary.org/obo/HP_0030090	Abnormal muscle fiber merosin expression		Lack of merosin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030092	Reduced muscle fiber merosin	http://purl.obolibrary.org/obo/HP_0030090	Abnormal muscle fiber merosin expression		A reduced amount of merosin in muscle fibers. This feature is usually assessed by immunohistochemical examination of muscle biopsy tissue.
http://purl.obolibrary.org/obo/HP_0030093	Abnormal muscle fiber laminin beta 1	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal of the amount of laminin beta 1 in muscle fiber tissue. Laminin 2 is a major component of the basal lamina of skeletal muscle cells. It is a heterotrimer composed of 3 chains: merosin (laminin alpha 2 chain), beta 1, and gamma 1.
http://purl.obolibrary.org/obo/HP_0030094	Reduced muscle fiber laminin beta 1	http://purl.obolibrary.org/obo/HP_0030093	Abnormal muscle fiber laminin beta 1		A reduced amount of laminin beta 1 in muscle fiber tissue. Laminin 2 is a major component of the basal lamina of skeletal muscle cells. It is a heterotrimer composed of 3 chains: merosin (laminin alpha 2 chain), beta 1, and gamma 1.
http://purl.obolibrary.org/obo/HP_0030095	Reduced muscle collagen VI	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A decreased amount of collagen VI in muscle tissue. Collagen VI is a primarily associated with the extracellular matrix of skeletal muscle.
http://purl.obolibrary.org/obo/HP_0030096	Abnormal muscle fiber dystrophin expression	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal in the amount of dystrophin in muscle fiber tissue. Dystrophin is located at the muscle sarcolemma in a membrane-spanning protein complex that connects the cytoskeleton to the basal lamina.
http://purl.obolibrary.org/obo/HP_0030097	Absent muscle dystrophin expression	http://purl.obolibrary.org/obo/HP_0030096	Abnormal muscle fiber dystrophin expression		Lack of dystrophin in muscle tissue. Immunohistochemistry reveals absent dystrophin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030098	Reduced muscle dystrophin expression	http://purl.obolibrary.org/obo/HP_0030096	Abnormal muscle fiber dystrophin expression		A decreased amount of dystrophin in muscle fiber tissue.
http://purl.obolibrary.org/obo/HP_0030099	Reduced muscle fiber alpha dystroglycan	http://purl.obolibrary.org/obo/HP_0030112	Abnormal muscle fiber alpha dystroglycan		Immunohistochemistry reveals reduced alpha dystroglycan protein in the muscle biopsy. Alpha-dystroglycan is a heavily glycosylated peripheral-membrane component of the dystrophin-associated glycoprotein complex (DAPC), which, in addition to laminin alpha2, binds perlecan and agrin in the extracellular matrix, whereas beta-dystroglycan, derived from the same gene, is a transmembrane protein that links to dystrophin intracellularly.
http://purl.obolibrary.org/obo/HP_0030100	Abnormal muscle fiber alpha sarcoglycan	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		Deviation from normal in the amount of alpha sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.
http://purl.obolibrary.org/obo/HP_0030101	Absent muscle fiber alpha sarcoglycan	http://purl.obolibrary.org/obo/HP_0030100	Abnormal muscle fiber alpha sarcoglycan		Lack of alpha sarcoglycan in muscle. Immunohistochemistry reveals absent alpha sarcoglycan protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030102	Reduced muscle fiber alpha sarcoglycan	http://purl.obolibrary.org/obo/HP_0030100	Abnormal muscle fiber alpha sarcoglycan		A decreased amount of alpha sarcoglycan in muscle. Immunohistochemistry reveals reduced alpha sarcoglycan protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030103	Abnormal muscle fiber beta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		Deviation from normal in the amount of beta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.
http://purl.obolibrary.org/obo/HP_0030104	Abnormal muscle fiber gamma sarcoglycan	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		Deviation from normal in the amount of gamma sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.
http://purl.obolibrary.org/obo/HP_0030105	Abnormal muscle fiber delta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		Deviation from normal in the amount of delta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.
http://purl.obolibrary.org/obo/HP_0030106	Absent muscle fiber beta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030103	Abnormal muscle fiber beta sarcoglycan		Immunohistochemistry shows complete lack of beta sarcoglycan protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030107	Reduced muscle fiber beta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030103	Abnormal muscle fiber beta sarcoglycan		Immunohistochemistry reveals reduced beta sarcoglycan protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030108	Reduced muscle fiber gamma sarcoglycan	http://purl.obolibrary.org/obo/HP_0030104	Abnormal muscle fiber gamma sarcoglycan		Immunohistochemistry reveals reduced gamma sarcoglycan protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030109	Absent muscle fiber gamma sarcoglycan	http://purl.obolibrary.org/obo/HP_0030104	Abnormal muscle fiber gamma sarcoglycan		Immunohistochemistry shows complete lack of gamma sarcoglycan protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030110	Absent muscle fiber delta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030105	Abnormal muscle fiber delta sarcoglycan		Immunohistochemistry shows complete lack of delta sarcoglycan protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030111	Reduced muscle fiber delta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030105	Abnormal muscle fiber delta sarcoglycan		Abnormally reduced amount of delta sarcoglycan in muscle.
http://purl.obolibrary.org/obo/HP_0030112	Abnormal muscle fiber alpha dystroglycan	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal of muscle alpha-dystroglcan expression. Alpha-dystroglycan is a heavily glycosylated peripheral-membrane component of the dystrophin-associated glycoprotein complex (DAPC), which, in addition to laminin alpha2, binds perlecan and agrin in the extracellular matrix, whereas beta-dystroglycan, derived from the same gene, is a transmembrane protein that links to dystrophin intracellularly.
http://purl.obolibrary.org/obo/HP_0030113	Abnormal muscle fiber dysferlin	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal in the expression of dysferlin in muscle tissue. Dysferlin is an ubiquitous 230-kDa transmembrane protein involved in calcium-mediated sarcolemma resealing.
http://purl.obolibrary.org/obo/HP_0030114	Absent muscle fiber dysferlin	http://purl.obolibrary.org/obo/HP_0030113	Abnormal muscle fiber dysferlin		Immunohistochemistry shows complete lack of dysferlin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030115	Reduced muscle fiber dysferlin	http://purl.obolibrary.org/obo/HP_0030113	Abnormal muscle fiber dysferlin		Immunohistochemistry reveals reduced dysferlin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030116	Abnormal muscle fiber emerin	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal of the amount of the inner nuclear membrane protein emerin in muscle tissue.
http://purl.obolibrary.org/obo/HP_0030117	Absent muscle fiber emerin	http://purl.obolibrary.org/obo/HP_0030116	Abnormal muscle fiber emerin		Immunohistochemistry shows complete lack of emerin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030118	Reduced muscle fiber emerin	http://purl.obolibrary.org/obo/HP_0030116	Abnormal muscle fiber emerin		Immunohistochemistry reveals reduced emerin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030119	Abnormal muscle fiber calpain-3	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal in the amount of calpain-3 in muscle tissue. Calpains are intracellular nonlysosomal cysteine proteases modulated by calcium ions. A typical calpain is a heterodimer composed of two distinct subunits, one large (over 80 kDa) and the other small (30 kDa). While only one gene encoding the small subunit has been demonstrated, there are many genes for the large one. CAPN3 is similar to ubiquitous Calpain 1 and 2 (m-calpain and micro-calpain), but contains specific insertion sequences (NS, IS1 and IS2). Calpains cleave target proteins to modify their properties, rather than breaking down the substrates.
http://purl.obolibrary.org/obo/HP_0030120	Absent muscle fiber calpain-3	http://purl.obolibrary.org/obo/HP_0030119	Abnormal muscle fiber calpain-3		Western blot shows complete lack of calpain-3 protein in the muscle biopsy tissue.
http://purl.obolibrary.org/obo/HP_0030121	Reduced muscle fiber calpain-3	http://purl.obolibrary.org/obo/HP_0030119	Abnormal muscle fiber calpain-3		Western blot reveals reduced calpain-3 protein in the muscle biopsy tissue.
http://purl.obolibrary.org/obo/HP_0030122	Reduced muscle fiber perlecan	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		Immunohistochemistry reveals reduced perlecan protein in the muscle biopsy. Perlecan is a basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) also known as heparan sulfate proteoglycan 2 (HSPG2).
http://purl.obolibrary.org/obo/HP_0030123	Abnormal muscle fiber lamin A/C	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from the normal amount of lamin A/C in muscle tissue. The LMNA gene gives rise to at least three splicing isoforms including the two main isoforms, lamin A and lamin C. These are constitutive components of the fibrous nuclear lamina and have different roles, ranging from mechanical nuclear membrane maintenance to gene regulation.
http://purl.obolibrary.org/obo/HP_0030124	Reduced muscle fiber lamin A/C	http://purl.obolibrary.org/obo/HP_0030123	Abnormal muscle fiber lamin A/C		A decreased amount of lamin A/C in muscle tissue. This feature can be shown by immunohistochemistry or Western blotting of muscle tissue.
http://purl.obolibrary.org/obo/HP_0030125	Sacralization of the fifth lumbar vertebra	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		A congenital anomaly, in which the transverse process of the last lumbar vertebra (L5) fuses to the sacrum on one side or both, or to ilium, or both.
http://purl.obolibrary.org/obo/HP_0030127	Endometriosis	http://purl.obolibrary.org/obo/HP_0030012	Abnormal female reproductive system physiology		The growth of endometrial tissue outside the uterus.
http://purl.obolibrary.org/obo/HP_0030129	Impaired ristocetin cofactor assay activity	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin to platelet-poor plasma.
http://purl.obolibrary.org/obo/HP_0030130	Impaired von Willebrand factor collagen binding activity	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Reduced ability of von Willebrand factor (vWF) to bind collagen. Abnormal response to collagen as manifested by reduced or lacking ability of plasma von WIllebrand Factor to bind collagen. An ELISA-based assay is typically used; the test is sensitive to loss of von Willebrand Factor high molecular weight multimers.
http://purl.obolibrary.org/obo/HP_0030131	Abnormal von Willebrand factor multimer distribution	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Deviation from the normal von Willebrand factor multimer pattern.
http://purl.obolibrary.org/obo/HP_0030132	Absence of large von Willebrand factor multimers	http://purl.obolibrary.org/obo/HP_0030131	Abnormal von Willebrand factor multimer distribution		Absence of large von Willebrand Factor multimers on gel electrophoresis.
http://purl.obolibrary.org/obo/HP_0030133	Abnormal presence of ultra-large von Willebrand factor multimers	http://purl.obolibrary.org/obo/HP_0030131	Abnormal von Willebrand factor multimer distribution		Detection of abnormal ultra-large von Willebrand factor multimers.
http://purl.obolibrary.org/obo/HP_0030134	Total absence von Willebrand factor multimers	http://purl.obolibrary.org/obo/HP_0030131	Abnormal von Willebrand factor multimer distribution		Complete absence of all von Willebrand factor multimers.
http://purl.obolibrary.org/obo/HP_0030135	Absence of intermediate von Willebrand factor multimers	http://purl.obolibrary.org/obo/HP_0030131	Abnormal von Willebrand factor multimer distribution		Lack of intermediate von Willebrand Factor multimers on gel electrophoresis.
http://purl.obolibrary.org/obo/HP_0030136	Enhanced ristocetin cofactor assay activity	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Abnormal response to ristocetin as manifested by increased aggregation of platelets upon addition of low-dose ristocetin to platelet-rich plasma.
http://purl.obolibrary.org/obo/HP_0030137	Prolonged bleeding following circumcision	http://purl.obolibrary.org/obo/HP_0011890	Prolonged bleeding following procedure		Bleeding that persists for a longer than usual time following circumcision.
http://purl.obolibrary.org/obo/HP_0030138	Excessive bleeding from superficial cuts	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		An abnormally increased degree of bleeding following a superficial injury to the surface of the skin.
http://purl.obolibrary.org/obo/HP_0030139	Excessive bleeding after a venipuncture	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		An abnormal high amount of bleeding following the procedure of taking a blood sample.
http://purl.obolibrary.org/obo/HP_0030140	Oral cavity bleeding	http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology		Recurrent or excessive bleeding from the mouth.
http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		A structural anomaly of the liver located predominantly in the hepatocytes as opposed to stromal cells.
http://purl.obolibrary.org/obo/HP_0030147	Truncal titubation	http://purl.obolibrary.org/obo/HP_0030187	Titubation		Tremor of the trunk in an anterior-posterior plane at 3-4 Hz.
http://purl.obolibrary.org/obo/HP_0030148	Heart murmur	http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound		An extra or unusual sound heard during a heartbeat caused vibrations resulting from the flow of blood through the heart.
http://purl.obolibrary.org/obo/HP_0030149	Cardiogenic shock	http://purl.obolibrary.org/obo/HP_0031273	Shock		Severely decreased cardiac output with evidence of inadequate end-organ perfusion (i.e., tissue hypoxia) in the presence of adequate intravascular volume.
http://purl.obolibrary.org/obo/HP_0030150	Plasmacytosis	http://purl.obolibrary.org/obo/HP_0004332	Abnormal lymphocyte morphology		An abnormally increased number of plasma cells in tissues, exudates, or blood
http://purl.obolibrary.org/obo/HP_0030151	Cholangitis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Inflammation of the biliary ductal system, affecting the intrahepatic or extrahepatic portions, or both.
http://purl.obolibrary.org/obo/HP_0030153	Cholangiocarcinoma	http://purl.obolibrary.org/obo/HP_0100574	Biliary tract neoplasm		Cholangiocarcinoma is a primary cancer originating in the biliary epithelium i.e., the cholangiocytes, of the extrahepatic and intrahepatic biliary ducts. It is extremely invasive, develops rapidly, often metastasizes, and has a very poor prognosis. They are slow growing tumors which spread longitudinally along the bile ducts with neural, perineural and subepithelial extension.
http://purl.obolibrary.org/obo/HP_0030154	Gallbladder perforation	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Rupture of the wall of the gallbladder.
http://purl.obolibrary.org/obo/HP_0030155	Scrotal pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the scrotum.
http://purl.obolibrary.org/obo/HP_0030156	Bence Jones Proteinuria	http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level		The presence of free monoclonal immunoglobulin light chains in the urine.
http://purl.obolibrary.org/obo/HP_0030158	Cervical ectropion	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		Cervical ectropion occurs when eversion of the endocervix exposes columnar epithelium to the vaginal milieu
http://purl.obolibrary.org/obo/HP_0030159	Cervical polyp	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		Abnormal growth of tissue projecting from a mucous membrane of the endocervix.
http://purl.obolibrary.org/obo/HP_0030160	Cervicitis	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		Inflammation of the uterine cervix.
http://purl.obolibrary.org/obo/HP_0030161	Vaginal pruritus	http://purl.obolibrary.org/obo/HP_0000989	Pruritus		A sensation of itching in the vagina.
http://purl.obolibrary.org/obo/HP_0030162	Glomerulomegaly	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Abnormally large size of glomeruli.
http://purl.obolibrary.org/obo/HP_0030164	Jaw claudication	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Pain in the jaw or ear induced by chewing or otherwise moving the jaw.
http://purl.obolibrary.org/obo/HP_0030165	Temporal artery tortuosity	http://purl.obolibrary.org/obo/HP_0430104	Abnormal superficial temporal artery morphology		The presence of an increased number of twists and turns of the temporal artery.
http://purl.obolibrary.org/obo/HP_0030166	Night sweats	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Occurrence of excessive sweating during sleep.
http://purl.obolibrary.org/obo/HP_0030167	Antimitochondrial antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against mitochondria.
http://purl.obolibrary.org/obo/HP_0030168	Dilated superficial abdominal veins	http://purl.obolibrary.org/obo/HP_0001015	Prominent superficial veins		Increase in diameter of the veins located underneath the skin of the abdomen.
http://purl.obolibrary.org/obo/HP_0030169	Gastric varix	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		Extreme dilation of the submucusoal veins in the stomach.
http://purl.obolibrary.org/obo/HP_0030170	Cystic artery pseudoaneurysm	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Presence of a pseudoaneurysm in the artery that supplies the gallbladder and cystic duct with blood. A pseudoaneurysm, also known as a false aneurysm, forms when blood leaks through a breach of the arterial wall but is contained by the adventitia or surrounding perivascular soft tissue.
http://purl.obolibrary.org/obo/HP_0030171	Perirenal hematoma	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		A collection of clotted blood surrounding the kidney.
http://purl.obolibrary.org/obo/HP_0030172	Peripheral amyelination	http://purl.obolibrary.org/obo/HP_0003130	Abnormal peripheral myelination		Congenital absence of the myelin sheath on a nerve.
http://purl.obolibrary.org/obo/HP_0030174	Increased peripheral myelin thickness	http://purl.obolibrary.org/obo/HP_0030173	Peripheral hypermyelination		Elevated thickness of the myelin sheath of peripheral nerves, in a regular and concentric fashion.
http://purl.obolibrary.org/obo/HP_0030175	Myelin tomacula	http://purl.obolibrary.org/obo/HP_0030173	Peripheral hypermyelination		The presence of multiple sausage-shaped swellings of the myelin sheath (The Latin tomaculum means sausage).
http://purl.obolibrary.org/obo/HP_0030176	Asymmetric peripheral demyelination	http://purl.obolibrary.org/obo/HP_0011096	Peripheral demyelination		Loss of myelin from peripheral nerves in a pattern that differs between right and left.
http://purl.obolibrary.org/obo/HP_0030180	Oppenheim reflex	http://purl.obolibrary.org/obo/HP_0007256	Abnormal pyramidal sign		Dorsiflexion of the big toe, sometimes accompanied by fanning of the other toes, elicited by stroking along the medial side of the tibia (the normal response would be no movement of the big toe).
http://purl.obolibrary.org/obo/HP_0030181	Gordon reflex	http://purl.obolibrary.org/obo/HP_0007256	Abnormal pyramidal sign		Dorsal extension of the big toe, sometimes accompanied by fanning of the other toes, elicited by compressing the calf muscles (a normal response is no movement of the big toe).
http://purl.obolibrary.org/obo/HP_0030183	Impaired visually enhanced vestibulo-ocular reflex	http://purl.obolibrary.org/obo/HP_0007670	Abnormal vestibulo-ocular reflex		The vestibulo-ocular reflex is responsible for the stabilization of the retinal image during movement. The visual vestibular ocular reflex (VVOR) or visual enhanced VOR, maintains ocular stability during head motion by generating compensatory eye movement opposite to head movement, and is a major component of visual vestibular interaction. This feature is an impairment of this reflex, manifested as the combined impairment of the three compensatory eye movement reflexes, namely the vestibulo-ocular reflex (VOR), smooth pursuit (SP) and optokinetic reflex (OKR).
http://purl.obolibrary.org/obo/HP_0030185	Isometric tremor	http://purl.obolibrary.org/obo/HP_0002345	Action tremor		An isometric tremor occurs with muscle contraction against a rigid stationary object (e.g., when making a fist).
http://purl.obolibrary.org/obo/HP_0030190	Oral motor hypotonia	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		Reduced muscle tone of oral musculature. In infants, this feature may be associated with difficulties in breast feeding, and may affect the latch, jaw motions, tongue placement, lip seal, suck/swallow/breathe pattern and overall feeding behavior.
http://purl.obolibrary.org/obo/HP_0030192	Fatigable weakness of bulbar muscles	http://purl.obolibrary.org/obo/HP_0003473	Fatigable weakness		A type of weakness of the bulbar muscles (muscles of the mouth and throat responsible for speech and swallowing) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030193	Fatigable weakness of chewing muscles	http://purl.obolibrary.org/obo/HP_0030192	Fatigable weakness of bulbar muscles		A type of weakness of the muscles involved in chewing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030194	Fatigable weakness of speech muscles	http://purl.obolibrary.org/obo/HP_0030192	Fatigable weakness of bulbar muscles		A type of weakness of the muscles involved in speech that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030195	Fatigable weakness of swallowing muscles	http://purl.obolibrary.org/obo/HP_0030192	Fatigable weakness of bulbar muscles		A type of weakness of the muscles involved in swallowing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030196	Fatigable weakness of respiratory muscles	http://purl.obolibrary.org/obo/HP_0003473	Fatigable weakness		A type of weakness of the muscles involved in breathing (respiration) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030197	Fatigable weakness of skeletal muscles	http://purl.obolibrary.org/obo/HP_0003473	Fatigable weakness		A type of weakness of skeletal muscle that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030198	Fatigable weakness of distal limb muscles	http://purl.obolibrary.org/obo/HP_0030197	Fatigable weakness of skeletal muscles		A type of weakness of a skeletal muscle of distal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030199	Fatigable weakness of neck muscles	http://purl.obolibrary.org/obo/HP_0030197	Fatigable weakness of skeletal muscles		A type of weakness of a skeletal muscle in the neck that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030200	Fatiguable weakness of proximal limb muscles	http://purl.obolibrary.org/obo/HP_0030197	Fatigable weakness of skeletal muscles		A type of weakness of a skeletal muscle of proximal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
http://purl.obolibrary.org/obo/HP_0030201	Response to drugs acting on neuromuscular transmission	http://purl.obolibrary.org/obo/HP_0030191	Abnormal peripheral nervous system synaptic transmission		Specific drugs interfere selectively with the different cellular mechanisms involved in neuromuscular transmission (synthesis, storage, release, action and inactivation of transmitter). The response of a patient to a specific drug can therefore be useful information for the differential diagnosis.
http://purl.obolibrary.org/obo/HP_0030202	Favorable response of weakness to acetylcholine esterase inhibitors	http://purl.obolibrary.org/obo/HP_0030201	Response to drugs acting on neuromuscular transmission		Improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor.
http://purl.obolibrary.org/obo/HP_0030203	Unfavorable response of muscle weakness to acetylcholine esterase inhibitors	http://purl.obolibrary.org/obo/HP_0030201	Response to drugs acting on neuromuscular transmission		Lack of improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor.
http://purl.obolibrary.org/obo/HP_0030205	Increased jitter at single fiber EMG	http://purl.obolibrary.org/obo/HP_0030006	Single fiber EMG abnormality		The variation in the time interval between the two action potentials of the same motor unit is called jitter. This term therefore applies to increased variability in the interval between successive action potentials of the same motor unit, which is measured by electromyography (EMG).
http://purl.obolibrary.org/obo/HP_0030206	EMG: incremental response of compound muscle action potential to repetitive nerve stimulation	http://purl.obolibrary.org/obo/HP_0100285	EMG: impaired neuromuscular transmission		A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to an abnormal increase in the amplitude during the course of the investigation.
http://purl.obolibrary.org/obo/HP_0030207	Paradoxical respiration	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Breathing movements in which the chest wall moves in on inspiration and out on expiration, in reverse of the normal movements. It may be seen in children with respiratory distress of any cause, which leads to indrawing of the intercostal spaces during inspiration. Patients with chronic airways obstruction also show indrawing of the lower ribs during inspiration, due to the distorted action of a depressed and flattened diaphragm. Crush injuries of the chest, with fractured ribs and sternum, can lead to a severe degree of paradoxical breathing.
http://purl.obolibrary.org/obo/HP_0030208	Anti-neuromuscular Junction acetylcholine receptor antibody positivity	http://purl.obolibrary.org/obo/HP_6001064	Anti-acetylcholine receptor antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neuromuscular junction acetylcholine receptors.
http://purl.obolibrary.org/obo/HP_0030209	Calcium channel antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against voltage-gated calcium channels.
http://purl.obolibrary.org/obo/HP_0030210	Anti-muscle-specific tyrosine kinase antibody	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against muscle specific kinase (anti-MuSK Ab).
http://purl.obolibrary.org/obo/HP_0030211	Slow pupillary light response	http://purl.obolibrary.org/obo/HP_0007695	Abnormal pupillary light reflex		Reduced velocity and acceleration in the pupillary light response.
http://purl.obolibrary.org/obo/HP_0030212	Collectionism	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		Excessive or pathological tendency to save and collect possessions.
http://purl.obolibrary.org/obo/HP_0030213	Emotional dearth	http://purl.obolibrary.org/obo/HP_0100851	Abnormal emotional state		A diminished ability to experience, express, or connect with emotions across both positive and negative valences. This state is often characterized by a pervasive sense of emotional disconnection or detachment, where the individual may report feeling "numb" or lacking emotional responses that were previously present. The reduction can range from mild dampening of emotional responses to a near-total absence of emotional engagement. It is important to consider the individual's baseline emotional competence, as changes in emotional capacity may be more indicative of this phenomenon in those with a previously broad emotional range.
http://purl.obolibrary.org/obo/HP_0030215	Inappropriate crying	http://purl.obolibrary.org/obo/HP_5200261	Abnormal demeanor		Uncontrolled episodes of crying occur without any apparent motivating stimuli.
http://purl.obolibrary.org/obo/HP_0030216	Inertia	http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition		Reduction of goal-directed behaviors linked to the impairment in frontal executive functions (planning of an action for example).
http://purl.obolibrary.org/obo/HP_0030217	Limb apraxia	http://purl.obolibrary.org/obo/HP_0002186	Apraxia		Difficulty in performing the correct execution of limbs movements in absence of motor impairment.
http://purl.obolibrary.org/obo/HP_0030218	Punding	http://purl.obolibrary.org/obo/HP_0000733	Motor stereotypy		Punding is a stereotypical motor behavior characterized by an intense fascination with repetitive, excessive and non-goal oriented handling, and examining of objects.
http://purl.obolibrary.org/obo/HP_0030219	Semantic dementia	http://purl.obolibrary.org/obo/HP_0002145	Frontotemporal dementia		A progressive loss of the ability to remember the meaning of words, faces and objects.
http://purl.obolibrary.org/obo/HP_0030221	Sweet craving	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		Excessive desire to eat sweet foods.
http://purl.obolibrary.org/obo/HP_0030222	Visual agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The condition is known as visual agnosia, which refers to the inability to recognize objects that are visually presented, even though the individual may have normal visual field, acuity, color vision, brightness discrimination, language, and memory.
http://purl.obolibrary.org/obo/HP_0030223	Perseverative thought	http://purl.obolibrary.org/obo/HP_0025769	Disordered formal thought process		The repetitive production of the same response to different commands.
http://purl.obolibrary.org/obo/HP_0030224	Abnormal muscle fiber desmin	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal in the expression of desmin in muscle tissue. Desmin is an 53-kDa protein.
http://purl.obolibrary.org/obo/HP_0030225	Accumulation of muscle fiber desmin	http://purl.obolibrary.org/obo/HP_0030224	Abnormal muscle fiber desmin		Immunohistochemistry shows accumulation of desmin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030226	Abnormal muscle fiber myotilin	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal in the expression of myotilin in muscle tissue. Myotilin is a 57kDa cytoskeletal protein.
http://purl.obolibrary.org/obo/HP_0030227	Accumulation of muscle fiber myotilin	http://purl.obolibrary.org/obo/HP_0030226	Abnormal muscle fiber myotilin		Immunohistochemistry shows accumulation of myotilin protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030228	Abnormal muscle fiber valosin-containing protein	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		A deviation from normal in the expression of valosin-containing protein in muscle tissue. Valosin-containing protein is an ubiquitously expressed multifunctional 100-kD protein that is a member of the AAA+ (ATPase associated with various activities) protein family.
http://purl.obolibrary.org/obo/HP_0030229	Accumulation of muscle fiber valosin-containing protein	http://purl.obolibrary.org/obo/HP_0030228	Abnormal muscle fiber valosin-containing protein		Immunohistochemistry shows accumulation of valosin-containing protein in the muscle biopsy.
http://purl.obolibrary.org/obo/HP_0030230	Central core regions in muscle fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		The presence of disorganized areas called cores in the center of muscle fibers. There is a typical appearance of the biopsy on light microscopy, where the muscle cells have cores that are devoid of mitochondria and specific enzymes. Cores are typically well demarcated and centrally located, but may occasionally be multiple and of eccentric.
http://purl.obolibrary.org/obo/HP_0030231	Glycogen accumulation in muscle fiber lysosomes	http://purl.obolibrary.org/obo/HP_0009051	Increased muscle glycogen content		An increased amount of glycogen in muscle tissue found specifically in lysosomes.
http://purl.obolibrary.org/obo/HP_0030232	Increased sarcoplasmic glycogen	http://purl.obolibrary.org/obo/HP_0009051	Increased muscle glycogen content		Elevated glycogen content in the sarcoplasm (cytoplasm) of muscle fibers.
http://purl.obolibrary.org/obo/HP_0030233	Bethlem sign	http://purl.obolibrary.org/obo/HP_0009473	Joint contracture of the hand		Limitation of wrist and finger extension on asking patient to form a prayer sign. This is a result of progressive wrist and finger flexion contractures.
http://purl.obolibrary.org/obo/HP_0030234	Highly elevated creatine kinase	http://purl.obolibrary.org/obo/HP_0003236	Elevated circulating creatine kinase activity		An increased CPK level between 4X and 50X above the upper normal level.
http://purl.obolibrary.org/obo/HP_0030235	Extremely elevated creatine kinase	http://purl.obolibrary.org/obo/HP_0003236	Elevated circulating creatine kinase activity		An increased creatine kinase level more than 50X above the upper normal level.
http://purl.obolibrary.org/obo/HP_0030241	Hypoplasia of deltoid muscle	http://purl.obolibrary.org/obo/HP_0008952	Shoulder muscle hypoplasia		Underdevelopment of the deltoid muscle.
http://purl.obolibrary.org/obo/HP_0030242	Portal vein thrombosis	http://purl.obolibrary.org/obo/HP_0030247	Splanchnic vein thrombosis		Thrombosis of the portal vein and/or its tributaries, which include the splenic vein and the superior and inferior mesenteric veins.
http://purl.obolibrary.org/obo/HP_0030243	Hepatic vein thrombosis	http://purl.obolibrary.org/obo/HP_0030247	Splanchnic vein thrombosis		An obstruction in the veins of the liver caused by a blood clot (thrombosis).
http://purl.obolibrary.org/obo/HP_0030244	Maternal fever in pregnancy	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		The occurrence of an elevated body temperature of the mother during pregnancy.
http://purl.obolibrary.org/obo/HP_0030245	Intrapartum fever	http://purl.obolibrary.org/obo/HP_0030244	Maternal fever in pregnancy		The occurrence of maternal fever during labor.
http://purl.obolibrary.org/obo/HP_0030246	Maternal first trimester fever	http://purl.obolibrary.org/obo/HP_0030244	Maternal fever in pregnancy		The occurrence of fever in a mother during the first trimester of pregnancy.
http://purl.obolibrary.org/obo/HP_0030247	Splanchnic vein thrombosis	http://purl.obolibrary.org/obo/HP_0004936	Venous thrombosis		The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (hepatic vein thrombosis), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis; the word splanchnic is used to refer to the visceral organs (of the abdominal cavity).
http://purl.obolibrary.org/obo/HP_0030248	Mesenteric venous thrombosis	http://purl.obolibrary.org/obo/HP_0030247	Splanchnic vein thrombosis		A clot that obstructs blood flow in a mesenteric vein (the superior and the inferior mesenteric vein drain blood from the small and large intestine).
http://purl.obolibrary.org/obo/HP_0030249	Enanthema	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		A sudden eruption (rash) of the surface of a mucous membrane of the mouth or pharynx.
http://purl.obolibrary.org/obo/HP_0030250	Pulmonary granulomatosis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		The presence of multiple granulomata (small nodular inflammatory lesions containing grouped mononuclear phagocytes) in the lung.
http://purl.obolibrary.org/obo/HP_0030252	Absent circulating B cells	http://purl.obolibrary.org/obo/HP_0010975	Abnormal total B cell count		Absence of detectable circulating B cells, commonly characterized as CD19+ or CD20+ lymphocytes, in the blood. Usually, less than 20 cells per microlitre is considered to be an absence.
http://purl.obolibrary.org/obo/HP_0030254	Nail bed hemorrhage	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Small areas of bleeding (hemorrhage) under the fingernail or toenail.
http://purl.obolibrary.org/obo/HP_0030257	Freckled genitalia	http://purl.obolibrary.org/obo/HP_0012293	Abnormal genital pigmentation		One or more brown punctate macules on the skin of the genitalia.
http://purl.obolibrary.org/obo/HP_0030258	Hyperpigmented genitalia	http://purl.obolibrary.org/obo/HP_0012293	Abnormal genital pigmentation		Localized or generalized increased genital pigmentation.
http://purl.obolibrary.org/obo/HP_0030259	Hypopigmented genitalia	http://purl.obolibrary.org/obo/HP_0012293	Abnormal genital pigmentation		Localized or generalized decreased genital pigmentation.
http://purl.obolibrary.org/obo/HP_0030260	Microphallus	http://purl.obolibrary.org/obo/HP_0008736	Hypoplasia of penis		Length of penis more than 2 SD below the mean for age accompanied by hypospadias.
http://purl.obolibrary.org/obo/HP_0030261	Absent penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Lack of recognizable penile structures.
http://purl.obolibrary.org/obo/HP_0030262	Narrow penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Penile width more than 2 standard deviations (SD) below the mean for age. Alternatively circumference of the flaccid penis more than 2 SD below the mean for age. Alternatively, apparently decreased penile width for age.
http://purl.obolibrary.org/obo/HP_0030263	Torsion of the penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Rotated position of the glans, with or without the penile shaft, of 30 degrees or more.
http://purl.obolibrary.org/obo/HP_0030264	Webbed penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Ventral skinfold extending from penis to scrotum.
http://purl.obolibrary.org/obo/HP_0030265	Wide penis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Distance between left and right side of the flaccid penis at the attachment to the skin above the pubic symphysis more than 2 standard deviations above the mean for age.
http://purl.obolibrary.org/obo/HP_0030267	Calcification of the interosseus membrane of the forearm	http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology		Deposition of calcium salts in the fibrous sheet that connects the radius and the ulna.
http://purl.obolibrary.org/obo/HP_0030268	Hyperplastic callus formation	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Increased growth of callus, the bony and cartilaginous material that forms a connecting bridge across a bone fracture during fracture healing.
http://purl.obolibrary.org/obo/HP_0030269	Increased circulating insulin-like growth factor 1 concentration	http://purl.obolibrary.org/obo/HP_0030352	Abnormal circulating insulin-like growth factor 1 concentration		The concentration of insulin-like growth factor 1 (IGF1) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0030270	Elevated red cell adenosine deaminase activity	http://purl.obolibrary.org/obo/HP_4000209	Abnormal erythrocyte adenosine deaminase activity		Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.
http://purl.obolibrary.org/obo/HP_0030271	Reduced erythrocyte 2,3-diphosphoglycerate concentration	http://purl.obolibrary.org/obo/HP_0034737	Abnormal erythrocyte metabolite concentration		This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes. 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation.
http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity	http://purl.obolibrary.org/obo/HP_0034684	Abnormal enzyme concentration or activity		An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme.
http://purl.obolibrary.org/obo/HP_0030273	Reduced red cell adenosine deaminase level	http://purl.obolibrary.org/obo/HP_4000209	Abnormal erythrocyte adenosine deaminase activity		Decrease in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.
http://purl.obolibrary.org/obo/HP_0030274	Accessory scrotum	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Additional scrotum, or part of a scrotum in an abnormal location.
http://purl.obolibrary.org/obo/HP_0030275	Ectopic scrotum	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		Scrotum in a position other than the usual position inferior to the base of the penis.
http://purl.obolibrary.org/obo/HP_0030278	Hypoplastic vertebral pedicle	http://purl.obolibrary.org/obo/HP_0030277	Abnormal vertebral pedicle morphology		Underdeveloped vertebral pedicle.
http://purl.obolibrary.org/obo/HP_0030279	Hypoplastic L5 vertebral pedicle	http://purl.obolibrary.org/obo/HP_0030278	Hypoplastic vertebral pedicle		Underdeveloped pedicle of the fifth lumbar vertebra.
http://purl.obolibrary.org/obo/HP_0030280	Rib gap	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		Radiolucent focal defect of a rib shaft.
http://purl.obolibrary.org/obo/HP_0030281	Cervical C3/C4 vertebral fusion	http://purl.obolibrary.org/obo/HP_0002949	Fused cervical vertebrae		Fusion of cervical vertebrae at C3 and C4, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development.
http://purl.obolibrary.org/obo/HP_0030282	Posterior rib gap	http://purl.obolibrary.org/obo/HP_0030280	Rib gap		Radiolucent focal defect of the posterior portion of a rib shaft. The 'gaps' may lead to flail chest.
http://purl.obolibrary.org/obo/HP_0030283	Partial absence of the septum pellucidum	http://purl.obolibrary.org/obo/HP_0007375	Abnormal septum pellucidum morphology		Only part of the septum pellucidum (a thin, triangular, vertical membrane separating the lateral ventricles of the brain) is present. This feature can be appreciated on magnetic resonance tomography or computed tomography of the brain.
http://purl.obolibrary.org/obo/HP_0030284	Triangular tongue	http://purl.obolibrary.org/obo/HP_0000158	Macroglossia		A form of macrogloassia (increased size of the tongue) characterized by a broad based root of the tongue but a small tongue tip, giving the appearance of a triangle.
http://purl.obolibrary.org/obo/HP_0030285	Splayed superior cerebellar peduncle	http://purl.obolibrary.org/obo/HP_0011932	Abnormal superior cerebellar peduncle morphology		Abnormal splayed configuration (spreading out) of the superior cerebellar peduncle.
http://purl.obolibrary.org/obo/HP_0030286	Atrophic superior cerebellar peduncle	http://purl.obolibrary.org/obo/HP_0011932	Abnormal superior cerebellar peduncle morphology		Atrophy of the superior cerebellar peduncle.
http://purl.obolibrary.org/obo/HP_0030290	Unossified sacrum	http://purl.obolibrary.org/obo/HP_0025370	Abnormal ossification of the sacrum		Lack of ossification of the sacrum.
http://purl.obolibrary.org/obo/HP_0030292	Tibial metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0030291	Lower-limb metaphyseal irregularity		Irregularity of the normally smooth surface of a metaphysis of a tibia.
http://purl.obolibrary.org/obo/HP_0030293	Fibular metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0030291	Lower-limb metaphyseal irregularity		Irregularity of the normally smooth surface of a metaphysis of a fibula.
http://purl.obolibrary.org/obo/HP_0030300	10 pairs of ribs	http://purl.obolibrary.org/obo/HP_0000921	Missing ribs		Presence of only 10 (instead of the usual 12) pairs of ribs.
http://purl.obolibrary.org/obo/HP_0030301	Abnormality of the anterior commissure	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		An anomaly of the anterior commissure, a bundle of nerve fibers that connect the two cerebral hemispheres across the midline. The anterior commissure plays a role in pain sensation and contains decussating fibers from the olfactory tracts.
http://purl.obolibrary.org/obo/HP_0030302	Agenesis of the anterior commissure	http://purl.obolibrary.org/obo/HP_0030301	Abnormality of the anterior commissure		Absence of the anterior commissure.
http://purl.obolibrary.org/obo/HP_0030303	Hypoplastic anterior commissure	http://purl.obolibrary.org/obo/HP_0030301	Abnormality of the anterior commissure		Underdevelopment of the anterior commissure.
http://purl.obolibrary.org/obo/HP_0030306	11 thoracic vertebrae	http://purl.obolibrary.org/obo/HP_0030305	Decreased number of vertebrae		The presence of 11 instead of the normal 12 thoracic vertebrae.
http://purl.obolibrary.org/obo/HP_0030308	Flared distal tibial metaphysis	http://purl.obolibrary.org/obo/HP_0030307	Flared lower limb metaphysis		The presence of a splayed (i.e.,flared) metaphyseal segment of the distal tibia.
http://purl.obolibrary.org/obo/HP_0030309	Flared distal fibular metaphysis	http://purl.obolibrary.org/obo/HP_0030307	Flared lower limb metaphysis		The presence of a splayed (i.e.,flared) metaphyseal segment of the distal fibula.
http://purl.obolibrary.org/obo/HP_0030312	Obliteration of the calvarial diploe	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Absence of the spongy bone structure (or tissue) of the internal part of the skull cap (i.e., of the calvarial diploe).
http://purl.obolibrary.org/obo/HP_0030318	Angular cheilitis	http://purl.obolibrary.org/obo/HP_0100825	Cheilitis		A type of inflammation of the lips involving one or both of the corners of the mouth.
http://purl.obolibrary.org/obo/HP_0030320	Increased intervertebral space	http://purl.obolibrary.org/obo/HP_0005108	Abnormal intervertebral disk morphology		An increase in the vertical distance between adjacent vertebral bodies, observed as an increase in the intervertebral disk space.
http://purl.obolibrary.org/obo/HP_0030321	Abnormal vertebral artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		An anomaly of the vertebral artery, the major artery of the neck that originates from the subclavian artery and merges to form the single midline basilar artery in a complex called the vertebrobasilar system.
http://purl.obolibrary.org/obo/HP_0030322	Vertebral artery hypoplasia	http://purl.obolibrary.org/obo/HP_0030321	Abnormal vertebral artery morphology		Underdevelopment of the vertebral artery.
http://purl.obolibrary.org/obo/HP_0030323	Unilateral vertebral artery hypoplasia	http://purl.obolibrary.org/obo/HP_0030322	Vertebral artery hypoplasia		Underdevelopment of the vertebral artery on one side.
http://purl.obolibrary.org/obo/HP_0030324	Bilateral vertebral artery hypoplasia	http://purl.obolibrary.org/obo/HP_0030322	Vertebral artery hypoplasia		Underdevelopment of the vertebral artery on both sides.
http://purl.obolibrary.org/obo/HP_0030325	Cervicomedullary schisis	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		Fissure within the spinal cord of the neck.
http://purl.obolibrary.org/obo/HP_0030326	Abnormal macrophage count	http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology		An anomaly in the number of macrophages.
http://purl.obolibrary.org/obo/HP_0030327	Abnormal osteoclast count	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		An anomaly in the number of osteoclasts in bone tissue, bone-resorbing cells that develop from macrophages. This finding can be observed by histological examination of bone tissue.
http://purl.obolibrary.org/obo/HP_0030328	Decreased osteoclast count	http://purl.obolibrary.org/obo/HP_0030327	Abnormal osteoclast count		Decreased number of osteoclasts in bone tissue.
http://purl.obolibrary.org/obo/HP_0030329	Retinal thinning on OCT	http://purl.obolibrary.org/obo/HP_0020040	Abnormal anteroposterior retina thickness on OCT		Reduced anteroposterior thickness of the retina. This phenotype can be appreciated by retinal optical coherence tomography (OCT).
http://purl.obolibrary.org/obo/HP_0030330	Multinucleated giant chondrocytes in epiphyseal cartilage	http://purl.obolibrary.org/obo/HP_0032929	Abnormal chondrocyte morphology		The presence of cartilage cells (chondrocytes) that are substantially increased in size and contain more than one nucleus and are located within the resting zone of the epiphyseal cartilage.
http://purl.obolibrary.org/obo/HP_0030331	Impaired stimulus-induced skin wrinkling	http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology		A reduced ability of the skin of the fingertips to wrinkle when exposed to stimuli such as soaking in water or application of EMLA cream (the fingertip remains smooth).
http://purl.obolibrary.org/obo/HP_0030339	Decreased circulating gonadotropin concentration	http://purl.obolibrary.org/obo/HP_0030338	Abnormal circulating gonadotropin concentration		A reduction of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
http://purl.obolibrary.org/obo/HP_0030341	Decreased circulating follicle stimulating hormone concentration	http://purl.obolibrary.org/obo/HP_0030346	Abnormal circulating follicle-stimulating hormone concentration		A reduction of the circulating level of follicle-stimulating hormone (FSH).
http://purl.obolibrary.org/obo/HP_0030344	Decreased circulating luteinizing hormone level	http://purl.obolibrary.org/obo/HP_0030339	Decreased circulating gonadotropin concentration		A reduction in the circulating level of luteinizing hormone (LH).
http://purl.obolibrary.org/obo/HP_0030346	Abnormal circulating follicle-stimulating hormone concentration	http://purl.obolibrary.org/obo/HP_0030338	Abnormal circulating gonadotropin concentration		An anomaly of the circulating level of follicle-stimulating hormone (FSH).
http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level	http://purl.obolibrary.org/obo/HP_0033799	Abnormal circulating sex hormone concentration		An anomaly in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.
http://purl.obolibrary.org/obo/HP_0030348	Increased circulating androgen concentration	http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level		An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.
http://purl.obolibrary.org/obo/HP_0030349	Decreased circulating androgen concentration	http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level		A reduction in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.
http://purl.obolibrary.org/obo/HP_0030350	Erythematous papule	http://purl.obolibrary.org/obo/HP_0200034	Papule		A circumscribed, solid elevation of skin with no visible fluid that is reddish (erythematous) in color.
http://purl.obolibrary.org/obo/HP_0030351	Urticarial plaque	http://purl.obolibrary.org/obo/HP_0200035	Skin plaque		A well-circumscribed, intensely pruritic, raised wheal (edema of the superficial skin) typically 1 to 2 cm in diameter.
http://purl.obolibrary.org/obo/HP_0030352	Abnormal circulating insulin-like growth factor 1 concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030353	Decreased circulating insulin-like growth factor 1 concentration	http://purl.obolibrary.org/obo/HP_0030352	Abnormal circulating insulin-like growth factor 1 concentration		The concentration of insulin-like growth factor 1 (IGF1) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0030355	Abnormal circulating interferon-gamma concentration	http://purl.obolibrary.org/obo/HP_0011116	Abnormal circulating interferon concentration		Abnormal levels of interferon gamma measured in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030356	Increased circulating interferon-gamma concentration	http://purl.obolibrary.org/obo/HP_0030355	Abnormal circulating interferon-gamma concentration		An elevation in the concentration of interferon gamma measured in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030357	Small cell lung carcinoma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		Small cell lung cancer (SCLC) is a type of highly malignant lung cancer that is composed of small ovoid cells. In the past, SCLC was called oat cell carcinoma because the microscopic appearance of the cells was felt to resemble oats. SLCLC usually originates near the bronchi and in many cases may grow and metastasize quickly.
http://purl.obolibrary.org/obo/HP_0030359	Squamous cell lung carcinoma	http://purl.obolibrary.org/obo/HP_0030358	Non-small cell lung carcinoma		A type of non-small cell lung carcinoma that is derived from stratified squamous epithelial cells.
http://purl.obolibrary.org/obo/HP_0030360	Large cell lung carcinoma	http://purl.obolibrary.org/obo/HP_0030358	Non-small cell lung carcinoma		A type of non-small cell lung carcinoma that is derived from undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung, and which is differentiate from small-cell lung carcinoma by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of salt-and-pepper appearance of the chromatin.
http://purl.obolibrary.org/obo/HP_0030362	Reduced muscle carnitine level	http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration		A reduction in the level of carnitine in muscle tissue.
http://purl.obolibrary.org/obo/HP_0030363	Primary Caesarian section	http://purl.obolibrary.org/obo/HP_0011410	Caesarean section		Delivery by Caesarian section representing the first time the mother has delivered by Caesarian section.
http://purl.obolibrary.org/obo/HP_0030364	Secondary Caesarian section	http://purl.obolibrary.org/obo/HP_0011410	Caesarean section		Delivery by Caesarian section representing where the mother has already had a previous Cesarean delivery, and this is a repeat Cesarean birth.
http://purl.obolibrary.org/obo/HP_0030365	Vaginal birth after Caesarean	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		Vaginal birth after Caesarean (VBAC) refers to the situation where the mother has had a previous Cesarean delivery but has now delivered vaginally.
http://purl.obolibrary.org/obo/HP_0030366	Delivery by Odon device	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		The Odon device is an instrument for assisted vaginal deliveries that is applied on the head of the baby and used to apply traction to assist the birth process.
http://purl.obolibrary.org/obo/HP_0030367	Finger hyperphalangy	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		Hyperphalangy is a digit morphology in which increased numbers of phalanges are arranged linearly within a digit. That is, there is an accessory phalanx that is arranged linearly with the other phalanges.
http://purl.obolibrary.org/obo/HP_0030368	Hyperphalangy of the 2nd finger	http://purl.obolibrary.org/obo/HP_0030367	Finger hyperphalangy		An accessory phalanx of the index (second) finger that is arranged linearly with the other phalanges. Hyperphalangy of the index finger results from an accessory ossification center at the metacarpophalangeal joint, resulting in radial deviation of the index finger. Note that this term refers only to this type of hyperphalangy.
http://purl.obolibrary.org/obo/HP_0030369	Induced vaginal delivery	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		Vaginal delivery following induction of labor, a procedure used to stimulate uterine contractions during pregnancy before labor begins on its own.
http://purl.obolibrary.org/obo/HP_0030370	Abnormal naive B cell proportion	http://purl.obolibrary.org/obo/HP_0025539	Abnormal B cell subset distribution		Abnormal increase or decrease of the naive B cell subpopulation, commonly characterized as CD27-IgM+, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0030371	Increased naive B cell proportion	http://purl.obolibrary.org/obo/HP_0030370	Abnormal naive B cell proportion		The proportion of naive B cellsin the blood circulation is above the upper limit of normal with respect to the reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0030372	Decreased naive B cell proportion	http://purl.obolibrary.org/obo/HP_0030370	Abnormal naive B cell proportion		The proportion of naive B cellsin the blood circulation is below the lower limit of normal with respect to the reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0030373	Abnormal memory B cell proportion	http://purl.obolibrary.org/obo/HP_0025539	Abnormal B cell subset distribution		A deviation of the normal proportion of memory B cells in circulation relative to total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).
http://purl.obolibrary.org/obo/HP_0030374	Decreased memory B cell proportion	http://purl.obolibrary.org/obo/HP_0030373	Abnormal memory B cell proportion		A reduction in the normal proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).
http://purl.obolibrary.org/obo/HP_0030375	Increased memory B cell proportion	http://purl.obolibrary.org/obo/HP_0030373	Abnormal memory B cell proportion		An elevation in the proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).
http://purl.obolibrary.org/obo/HP_0030376	Abnormal immature B cell proportion	http://purl.obolibrary.org/obo/HP_0025539	Abnormal B cell subset distribution		A deviation from normal proportion of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+).
http://purl.obolibrary.org/obo/HP_0030377	Increased immature B cell proportion	http://purl.obolibrary.org/obo/HP_0030376	Abnormal immature B cell proportion		An elevation in the proportion above normal of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+).
http://purl.obolibrary.org/obo/HP_0030378	Decreased immature B cell proportion	http://purl.obolibrary.org/obo/HP_0030376	Abnormal immature B cell proportion		A reduction in normal proportion of immature B cells (CD19+/ CD21low)in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+).
http://purl.obolibrary.org/obo/HP_0030379	Abnormal transitional B cell proportion	http://purl.obolibrary.org/obo/HP_0025539	Abnormal B cell subset distribution		Abnormal increase or decrease of the transitional B cell subpopulation, commonly characterized as CD27-CD24hiCD38hi or CD27-IgMhiCD38hi, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0030380	Decreased transitional B cell proportion	http://purl.obolibrary.org/obo/HP_0030379	Abnormal transitional B cell proportion		Abnormal decrease of the transitional B cell subpopulation, commonly characterized as CD27-CD24hiCD38hi or CD27-IgMhiCD38hi, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0030381	Increased transitional B cell proportion	http://purl.obolibrary.org/obo/HP_0030379	Abnormal transitional B cell proportion		Abnormal increase of the transitional B cell subpopulation, commonly characterized as CD27-CD24hiCD38hi or CD27-IgMhiCD38hi, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0030383	Abnormal marginal zone B cell proportion	http://purl.obolibrary.org/obo/HP_0030373	Abnormal memory B cell proportion		A deviation of the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells.
http://purl.obolibrary.org/obo/HP_0030384	Decreased marginal zone B cell proportion	http://purl.obolibrary.org/obo/HP_0030383	Abnormal marginal zone B cell proportion		A reduction in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells.
http://purl.obolibrary.org/obo/HP_0030385	Increased marginal zone B cell proportion	http://purl.obolibrary.org/obo/HP_0030383	Abnormal marginal zone B cell proportion		An elevation in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells.
http://purl.obolibrary.org/obo/HP_0030386	Abnormal class-switched memory B cell proportion	http://purl.obolibrary.org/obo/HP_0030373	Abnormal memory B cell proportion		A deviation of the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM-/IgD-) in circulation relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.
http://purl.obolibrary.org/obo/HP_0030387	Increased class-switched memory B cell proportion	http://purl.obolibrary.org/obo/HP_0030386	Abnormal class-switched memory B cell proportion		An increase in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.
http://purl.obolibrary.org/obo/HP_0030388	Decreased class-switched memory B cell proportion	http://purl.obolibrary.org/obo/HP_0030386	Abnormal class-switched memory B cell proportion		A reduction in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.
http://purl.obolibrary.org/obo/HP_0030389	Abnormal circulating thromboxane concentration	http://purl.obolibrary.org/obo/HP_0030361	Abnormal circulating eicosanoid concentration		Any deviation from the normal concentration of thromboxane in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030390	Reduced circulating leukotriene C4 concentration	http://purl.obolibrary.org/obo/HP_0030361	Abnormal circulating eicosanoid concentration		An abnormally decreased concentration of leukotriene C4 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030391	Spoken word recognition deficit	http://purl.obolibrary.org/obo/HP_0002463	Language impairment		Reduced ability of lexical discrimination, which refers to the process of distinguishing a stimulus word from other phonologically similar words. Lexical discrimination can be defined as the process of correctly identifying words in the mental lexicon to match the phonological input of a stimulus.
http://purl.obolibrary.org/obo/HP_0030392	Choroid plexus carcinoma	http://purl.obolibrary.org/obo/HP_0100836	Malignant neoplasm of the central nervous system		Intraventricular papillary neoplasm derived from choroid plexus epithelium. Plexus tumors are most common in the lateral and fourth ventricles; while 80% of lateral ventricle tumors present in children, fourth ventricle tumors are evenly distributed in all age groups. Clinically, choroid plexus tumors tend to cause hydrocephalus and increased intracranial pressure. Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III.
http://purl.obolibrary.org/obo/HP_0030393	Endolymphatic sac tumor	http://purl.obolibrary.org/obo/HP_0040096	Neoplasm of the inner ear		A low-grade papillary epithelial neoplasm (adenocarcinoma) with a slow growth pattern. The endolymphatic duct emerges from the posterior wall of the saccule (of the inner ear) and ends in a blind pouch, the endolymphatic sac. Endolymphatic sac tumors (ELSTs) are known under different names in the literature (Heffner tumor, aggressive papillary middle ear tumor, and low-grade adenocarcinoma of endolymphatic sac origin).
http://purl.obolibrary.org/obo/HP_0030394	Fallopian tube carcinoma	http://purl.obolibrary.org/obo/HP_0033020	Female reproductive system neoplasm		Carcinoma that originates in the Fallopian tube. It may be located in the wall or within the lumen as a growth attached to the wall by a stalk.
http://purl.obolibrary.org/obo/HP_0030396	Abnormal platelet granule secretion	http://purl.obolibrary.org/obo/HP_0011869	Abnormal platelet function		Platelets are replete with secretory granules, which are critical to normal platelet function. Among the three types of platelet secretory granules - alpha-granules, dense granules, and lysosomes - the alpha-granule is the most abundant. Granule contents must be released from their intracellular repository in order to achieve their physiologic function, and this term refers to a functional defect in granule secretion.
http://purl.obolibrary.org/obo/HP_0030397	Abnormal platelet dense granule secretion	http://purl.obolibrary.org/obo/HP_0030396	Abnormal platelet granule secretion		Abnormal release of dense granules from platelets.
http://purl.obolibrary.org/obo/HP_0030398	Abnormal platelet ATP dense granule secretion	http://purl.obolibrary.org/obo/HP_0030397	Abnormal platelet dense granule secretion		Abnormal secretion of the platelet dense-granule content adenosine triphosphate (ATP).
http://purl.obolibrary.org/obo/HP_0030399	Abnormal platelet alpha granule secretion	http://purl.obolibrary.org/obo/HP_0030396	Abnormal platelet granule secretion		Abnormal release of alpha granule contents from platelets.
http://purl.obolibrary.org/obo/HP_0030400	Abnormal platelet lysosome secretion	http://purl.obolibrary.org/obo/HP_0030396	Abnormal platelet granule secretion		Abnormal release of lysosome contents from platelets.
http://purl.obolibrary.org/obo/HP_0030401	Abnormal platelet dense granule ATP/ADP ratio	http://purl.obolibrary.org/obo/HP_0012484	Abnormal dense granules		Deviation from normal of the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) within platelets.
http://purl.obolibrary.org/obo/HP_0030403	Spontaneous platelet aggregation	http://purl.obolibrary.org/obo/HP_0030402	Abnormal platelet aggregation		Clumping together of platelets in the blood in a platelet aggregation test without addition of agents normally used to induce aggregation.
http://purl.obolibrary.org/obo/HP_0030404	Glucagonoma	http://purl.obolibrary.org/obo/HP_0030405	Pancreatic endocrine tumor		An endocrine tumor of the pancreas that secretes excessive amounts of glucagon.
http://purl.obolibrary.org/obo/HP_0030406	Primary peritoneal carcinoma	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum.
http://purl.obolibrary.org/obo/HP_0030407	Pineocytoma	http://purl.obolibrary.org/obo/HP_0030694	Pineal parenchymal cell neoplasm		A type of pineal parenchymal cell neoplasm that is a mature well-differentiated tumor (WHO grade I).
http://purl.obolibrary.org/obo/HP_0030408	Pineoblastoma	http://purl.obolibrary.org/obo/HP_0030694	Pineal parenchymal cell neoplasm		Pineoblastoma is a rare primitive neuroectodermal tumor (PNET) arising in the pineal gland. Pineoblastomas are classified as a WHO grade IV tumor and comprise one-fourth to one-half of pineal parenchymal tumors. Pineoblastoma is a highly cellular tumor originating in the pineal gland and containing small, poorly differentiated cells.
http://purl.obolibrary.org/obo/HP_0030409	Renal transitional cell carcinoma	http://purl.obolibrary.org/obo/HP_0009726	Renal neoplasm		A malignant tumor that arises from the transitional (urothelial) epithelial cells lining the urinary tract from the renal calyces to the ureteral orifice.
http://purl.obolibrary.org/obo/HP_0030410	Sebaceous gland carcinoma	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		A carcinoma that arises in a sebaseous gland (an exocrine gland of the skin that secretes sebum, a waxy substance)
http://purl.obolibrary.org/obo/HP_0030411	Jejunal adenocarcinoma	http://purl.obolibrary.org/obo/HP_0040274	Adenocarcinoma of the small intestine		A malignant epithelial tumor with a glandular organization that originates in the jejunum.
http://purl.obolibrary.org/obo/HP_0030412	Ileal adenocarcinoma	http://purl.obolibrary.org/obo/HP_0040274	Adenocarcinoma of the small intestine		A malignant epithelial tumor with a glandular organization that originates in the ileum.
http://purl.obolibrary.org/obo/HP_0030413	Squamous cell carcinoma of the tongue	http://purl.obolibrary.org/obo/HP_0100648	Neoplasm of the tongue		A carcinoma derived from a squamous epithelial cell of the tongue.
http://purl.obolibrary.org/obo/HP_0030414	Verrucous cell carcinoma of the tongue	http://purl.obolibrary.org/obo/HP_0030413	Squamous cell carcinoma of the tongue		A low-grade variant of squamous cell carcinoma of the tongue with a warty (verrucous) appearance.
http://purl.obolibrary.org/obo/HP_0030415	Sarcomatoid carcinoma of the tongue	http://purl.obolibrary.org/obo/HP_0030413	Squamous cell carcinoma of the tongue		Sarcomatoid (spindle cell) carcinomas of the tongue is a variant of squamous carcinoma of tongue that is monoclonal, having evolved from a conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation.
http://purl.obolibrary.org/obo/HP_0030416	Vulvar neoplasm	http://purl.obolibrary.org/obo/HP_0033020	Female reproductive system neoplasm		A tumor (abnormal growth of tissue) of the female external genital tract (vulva).
http://purl.obolibrary.org/obo/HP_0030417	Squamous cell carcinoma of the vulva	http://purl.obolibrary.org/obo/HP_0030416	Vulvar neoplasm		A cancer that originates in the squamous cells that line the surface of the vulva.
http://purl.obolibrary.org/obo/HP_0030418	Vulvar melanoma	http://purl.obolibrary.org/obo/HP_0030416	Vulvar neoplasm		A type of vulvar cancer that originates from melanocytes of the vulva.
http://purl.obolibrary.org/obo/HP_0030419	Bartholin gland carcinoma	http://purl.obolibrary.org/obo/HP_0030416	Vulvar neoplasm		A cancer arising in a cell of the Bartholin gland, a racemose gland located slightly posterior to the opening of the vagina.
http://purl.obolibrary.org/obo/HP_0030420	Vulvar adenocarcinoma	http://purl.obolibrary.org/obo/HP_0030416	Vulvar neoplasm		An adenocarcinoma arising in the vulva.
http://purl.obolibrary.org/obo/HP_0030423	Splenic cyst	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		A closed sac located in the spleen.
http://purl.obolibrary.org/obo/HP_0030424	Epididymal cyst	http://purl.obolibrary.org/obo/HP_0009714	Abnormal epididymis morphology		A smooth, extratesticular, spherical cyst in the head of the epididymis.
http://purl.obolibrary.org/obo/HP_0030425	Calcified ovarian cyst	http://purl.obolibrary.org/obo/HP_0000138	Ovarian cyst		A cyst of the ovary that exhibits deposition of calcium salts.
http://purl.obolibrary.org/obo/HP_0030426	Ossifying fibroma	http://purl.obolibrary.org/obo/HP_0010614	Fibroma		A benign central bone tumor composed of fibrous connective tissue within which bone is formed.
http://purl.obolibrary.org/obo/HP_0030427	Ossifying fibroma of the jaw	http://purl.obolibrary.org/obo/HP_0030426	Ossifying fibroma		A benign central bone tumor of the jaw composed of fibrous connective tissue within which bone is formed.
http://purl.obolibrary.org/obo/HP_0030428	Cutaneous myxoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		A myxoma originating in the skin.
http://purl.obolibrary.org/obo/HP_0030429	Juvenile nasopharyngeal angiofibroma	http://purl.obolibrary.org/obo/HP_0012288	Neoplasm of head and neck		A benign but highly vascular nasopharyngeal neoplasm. The tumor originates from the sphenopalatine foramen and involves both the pterygopalatine fossa and the posterior nasal cavity.
http://purl.obolibrary.org/obo/HP_0030430	Neuroma	http://purl.obolibrary.org/obo/HP_0100007	Neoplasm of the peripheral nervous system		A tumor made up of nerve cells and nerve fibers.
http://purl.obolibrary.org/obo/HP_0030431	Osteochondroma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A cartilage capped bony outgrowth of a long bone. Osteochondroma arises on the external surface of bone containing a marrow cavity that is continuous with that of the underlying bone.
http://purl.obolibrary.org/obo/HP_0030432	Chondroblastoma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells.
http://purl.obolibrary.org/obo/HP_0030433	Osteoid osteoma	http://purl.obolibrary.org/obo/HP_0100246	Osteoma		A bening tumor of bone composed of a central zone named nidus which is an atypical bone completely enclosed within a well vascularized stroma and a peripheral sclerotic reaction zone.
http://purl.obolibrary.org/obo/HP_0030434	Pilomatrixoma	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		Pilomatricoma is an asymptomatic slowly growing benign cutaneous tumor, differentiating towards the hair matrix of the hair follicle. It is covered by normal or hyperemic skin, and usually varies in size from 0.5 to 3 cm.
http://purl.obolibrary.org/obo/HP_0030436	Fibrofolliculoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		Fibrofolliculoma is a clinically asymptomatic, 2-4 mm, skin-colored, dome-shaped smooth papule. It usually arises in the form of multiple lesions in adults in different areas such as the scalp, forehead, face, and neck. According to histology, the lesion is a fibrotic hamartoma characterized by infundibular epithelial proliferation and perifollicular fibrous proliferation.
http://purl.obolibrary.org/obo/HP_0030438	Anal canal squamous cell carcinoma	http://purl.obolibrary.org/obo/HP_0030437	Anal canal neoplasm		A squamous cell carcinoma that originates in the anal canal.
http://purl.obolibrary.org/obo/HP_0030439	Anal canal adenocarcinoma	http://purl.obolibrary.org/obo/HP_0040275	Adenocarcinoma of the large intestine		An adenoma carcinoma that originates in the anal canal.
http://purl.obolibrary.org/obo/HP_0030440	Anal margin neoplasm	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A tumor of the anal margin.
http://purl.obolibrary.org/obo/HP_0030441	Anal margin Paget's disease	http://purl.obolibrary.org/obo/HP_0030440	Anal margin neoplasm		An intraepithelial adenocarcinoma originating in the anal margin and characterized by presence of typical Paget's cells, appearing as large rounded vacuolated cells.
http://purl.obolibrary.org/obo/HP_0030442	Anal margin squamous cell carcinoma	http://purl.obolibrary.org/obo/HP_0030440	Anal margin neoplasm		A squamous cell carcinoma that originates in the skin of the anal margin.
http://purl.obolibrary.org/obo/HP_0030443	Anal margin basal cell carcinoma	http://purl.obolibrary.org/obo/HP_0030440	Anal margin neoplasm		A basal cell carcinoma that originates in the anal margin.
http://purl.obolibrary.org/obo/HP_0030444	Anal margin melanoma	http://purl.obolibrary.org/obo/HP_0030440	Anal margin neoplasm		A melanoma that originates in the anal margin.
http://purl.obolibrary.org/obo/HP_0030445	Pulmonary carcinoid tumor	http://purl.obolibrary.org/obo/HP_0100570	Carcinoid tumor		A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma.
http://purl.obolibrary.org/obo/HP_0030447	Merkel cell skin cancer	http://purl.obolibrary.org/obo/HP_0040192	APUdoma		A malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. Most patients present with rapidly growing, painless, firm, non-tender, dome-shaped red, occasionally ulcerated skin nodules, which have a red or bluish color, measuring up to several centimeters, on predominantly sun-exposed areas of the body. The overlying skin is smooth and shiny, sometimes exhibiting ulcerative, acneiform or telangiectatic features.
http://purl.obolibrary.org/obo/HP_0030449	Therapeutic abortion	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		Delivery by means of therapeutic termination of pregnancy. Therapeutic abortion may be done to end a pregnancy if the mother's life is in danger or if the baby has abnormalities involving the major organ systems and is not expected to survive after birth or by choice.
http://purl.obolibrary.org/obo/HP_0030451	Mesenteric cyst	http://purl.obolibrary.org/obo/HP_0100016	Abnormal mesentery morphology		A closed fluid filled sac originating from the mesentary.
http://purl.obolibrary.org/obo/HP_0030452	Chylolymphatic mesenteric cyst	http://purl.obolibrary.org/obo/HP_0030451	Mesenteric cyst		A type of mesenteric cyst that is lined with a thin endothelium or mesothelium and filled with chylous and lymphatic fluid.
http://purl.obolibrary.org/obo/HP_0030465	Undetectable light-adapted electroretinogram	http://purl.obolibrary.org/obo/HP_0008275	Abnormal light-adapted electroretinogram		No detectable response to the light-adapted 3.0 ERG (single-flash cone response). This type of ERG measures responses of the cone system; a-waves arise from cone photoreceptors and cone off-bipolar cells; the b-wave comes from On- and Off-cone bipolar cells.
http://purl.obolibrary.org/obo/HP_0030467	Abnormal pattern electroretinogram	http://purl.obolibrary.org/obo/HP_0000512	Abnormal electroretinogram		An anomalous response to a pattern electroretinogram (PERG), a particular kind of ERG obtained in response to contrast modulation of patterned visual stimuli at constant mean luminance-typically contrast-reversing gratings or checkerboards-whose characteristics are fundamentally different from those of the traditional ERG in response to diffuse flashes of light.
http://purl.obolibrary.org/obo/HP_0030469	Abnormal dark-adapted electroretinogram	http://purl.obolibrary.org/obo/HP_0030466	Abnormal full-field electroretinogram		An electroretinographic anomaly detected by dark-adapted full-field ERG. The dark adapted ERG targets rod-pathway function.
http://purl.obolibrary.org/obo/HP_0030483	Reduced amplitude of dark-adapted bright flash electroretinogram a-wave	http://purl.obolibrary.org/obo/HP_0030478	Abnormal amplitude of dark-adapted bright flash electroretinogram		An abnormal reduction in the amplitude of the a-wave.
http://purl.obolibrary.org/obo/HP_0030484	Supernormal dark-adapted bright flash electroretinogram b-wave	http://purl.obolibrary.org/obo/HP_0030478	Abnormal amplitude of dark-adapted bright flash electroretinogram		The b-wave amplitude exceeding the upper limit of normal under scotopic (dark-adapted) conditions with high-intensity stimulation.
http://purl.obolibrary.org/obo/HP_0030491	Choriocapillaris atrophy	http://purl.obolibrary.org/obo/HP_0000533	Chorioretinal atrophy		Atrophy of the capillary lamina of choroid.
http://purl.obolibrary.org/obo/HP_0030495	Abnormal macular vasculature morphology	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		Any structural anomaly of the blood vessels of the macula.
http://purl.obolibrary.org/obo/HP_0030496	Macular exudate	http://purl.obolibrary.org/obo/HP_0030495	Abnormal macular vasculature morphology		Yellow-white intraretinal deposits in the macula typically associated with damaged inner blood-retina barrier and exudation of serous fluid and lipids from the retinal microvasculature.
http://purl.obolibrary.org/obo/HP_0030497	Macular cotton wool spot	http://purl.obolibrary.org/obo/HP_0031606	Retinal cotton wool spot		Fluffy white patch in the macula, representing localized areas of dense white swelling of the retinal nerve fiber layer.
http://purl.obolibrary.org/obo/HP_0030499	Macular drusen	http://purl.obolibrary.org/obo/HP_0011510	Drusen		Drusen localted in the macula.
http://purl.obolibrary.org/obo/HP_0030501	Macular crystals	http://purl.obolibrary.org/obo/HP_0030500	Yellow/white macular lesion		Crystalline deposits in the macula, located intra-retinally.
http://purl.obolibrary.org/obo/HP_0030503	Macular telangiectasia	http://purl.obolibrary.org/obo/HP_0030495	Abnormal macular vasculature morphology		Localized irregular dilatation of small tortuous intraretinal blood vessels in the macular area.
http://purl.obolibrary.org/obo/HP_0030504	Clustered congenital hypertrophy of retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0007649	Congenital hypertrophy of retinal pigment epithelium		Grouped, flat, well-demarcated pigmented lesions at the level of the pigment epithelium (that are said to resemble bear tracks). Less frequently, the lesions may be white ('polar bear tracks').
http://purl.obolibrary.org/obo/HP_0030505	Nummular pigmentation of the retina	http://purl.obolibrary.org/obo/HP_0007703	Abnormal retinal pigmentation		Clumped pigmentary changes of nummular appearance (i.e., thought to resemble the shape of a coin or multiple coins stuck together) at the level of the retinal pigment epithelium.
http://purl.obolibrary.org/obo/HP_0030507	Retinal crystals	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Crystalline deposits in the retina.
http://purl.obolibrary.org/obo/HP_0030511	Bradyopsia	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Difficulty in seeing moving objects.
http://purl.obolibrary.org/obo/HP_0030515	Moderately reduced visual acuity	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		Moderate reduction of the ability to see. On the 6m visual acuity scale, moderate reduction is defined as less than 6/18 but at least 6/60. On the 20ft visual acuity scale, moderate reduction is defined as less than 20/70 but at least 20/200. On the decimal visual acuity scale, moderate reduction is defined as less than 0.3 but at least 0.1.
http://purl.obolibrary.org/obo/HP_0030522	Mild constriction of peripheral visual field	http://purl.obolibrary.org/obo/HP_0001133	Constriction of peripheral visual field		A diminution of the peripheral visual field whereby at least 50 degrees of central field are preserved in all meridians.
http://purl.obolibrary.org/obo/HP_0030525	Moderate constriction of peripheral visual field	http://purl.obolibrary.org/obo/HP_0001133	Constriction of peripheral visual field		Peripheral visual field constriction with 20-49 degrees binocular visual field preserved.
http://purl.obolibrary.org/obo/HP_0030526	Severe constriction of peripheral visual field	http://purl.obolibrary.org/obo/HP_0001133	Constriction of peripheral visual field		Peripheral visual field constriction with 10-19 degrees central field preserved.
http://purl.obolibrary.org/obo/HP_0030527	Very severe constriction of peripheral visual field	http://purl.obolibrary.org/obo/HP_0001133	Constriction of peripheral visual field		Peripheral visual field constriction with <10 degrees central field preserved.
http://purl.obolibrary.org/obo/HP_0030529	Ring scotoma	http://purl.obolibrary.org/obo/HP_0000575	Scotoma		An annular field defect centered on fixation.
http://purl.obolibrary.org/obo/HP_0030588	Abnormal visual field test	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		Abnormal result of a test designed to test an individual's central and peripheral vision by determining the ability of the individual to perceive objects at differing locations of the visual field.
http://purl.obolibrary.org/obo/HP_0030599	Abnormal Esterman grid perimetry test	http://purl.obolibrary.org/obo/HP_0030595	Abnormal static automated perimetry test		The Esterman grid test assays scores visual acuity. The grid consists of 100 units whose unequal size and distribution reflect the unequal functional value of different parts of the field-in effect a weighted or relative-value scale. Because each unit equals 1 percent, a simple count of units yields the functional score in percent.
http://purl.obolibrary.org/obo/HP_0030602	Abnormal fundus autofluorescence imaging	http://purl.obolibrary.org/obo/HP_0030601	Abnormal posterior segment imaging		Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Autofluorescent patterns result from the complex interaction of fluorophores such a lipofuscin, which release an autofluorescent signal, and elements such as melanin and rhodopsin, which absorb the excitation beam and attenuate autofluorescence. Other structures such as retinal vessels and the crystalline lens may also influence autofluorescence through blocking and interference.
http://purl.obolibrary.org/obo/HP_0030603	Abnormal optical coherence tomography	http://purl.obolibrary.org/obo/HP_0030601	Abnormal posterior segment imaging		Optical coherence tomography (OCT) is an optical method for cross-sectional imaging with a resolution approaching that of histopathology and a depth of penetration of a few mm. In ophthalmology, OCT has become a standard of care for retinal imaging. This term groups abnormal findings that are considered OCT-specific.
http://purl.obolibrary.org/obo/HP_0030604	Abnormal fundus fluorescein angiography	http://purl.obolibrary.org/obo/HP_0030601	Abnormal posterior segment imaging		An abnormality observed by retinal fluorescein angiography, which involves the intravenous injection of fluorescein dye followed by fluorescent imaging of the fundus immediately after injection and for up to ten minutes thereafter. It can be used to study various retinal abnormalities including especially anomalies of the choroidal and retinal circulation.
http://purl.obolibrary.org/obo/HP_0030609	Photoreceptor layer loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT		Loss of the outer nuclear layer (photoreceptor layer) as assessed by ocular coherence tomography.
http://purl.obolibrary.org/obo/HP_0030631	Hyperautofluorescent macular lesion	http://purl.obolibrary.org/obo/HP_0025158	Hyperautofluorescent retinal lesion		Increased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging.
http://purl.obolibrary.org/obo/HP_0030632	Hypoautofluorescent macular lesion	http://purl.obolibrary.org/obo/HP_0025159	Hypoautofluorescent retinal lesion		Decreased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging.
http://purl.obolibrary.org/obo/HP_0030636	Occult macular dystrophy	http://purl.obolibrary.org/obo/HP_0007754	Macular dystrophy		Occult macular dystrophy is a, typically hereditary, abnormality of the macula associated with progressive foveal cone dysfunction and no apparent fundoscopic, full-field electroretinogram (ERG), or fluorescein angiogram abnormalities.
http://purl.obolibrary.org/obo/HP_0030642	Fundus albipunctatus	http://purl.obolibrary.org/obo/HP_0012045	Retinal flecks		Widespread white lesions of uniform, small and round appearance.
http://purl.obolibrary.org/obo/HP_0030645	Central	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that is located close to the median plane or midline of the body or of the referenced structure.
http://purl.obolibrary.org/obo/HP_0030652	Vitreous haze	http://purl.obolibrary.org/obo/HP_0011531	Vitritis		Vitreous haze is the obscuration of fundus details by vitreous cells and protein exudation.
http://purl.obolibrary.org/obo/HP_0030654	Umbilical cord cyst	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Any cystic lesion associated with the umbilical cord.
http://purl.obolibrary.org/obo/HP_0030655	Umbilical cord knot	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		An entwining of a segment of umbilical cord, usually without obstructing fetal circulation and commonly result from fetal slippage through a loop of the cord.
http://purl.obolibrary.org/obo/HP_0030656	Umbilical vein varix	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Focal dilation of the umbilical vein.
http://purl.obolibrary.org/obo/HP_0030657	Umbilical cord hematoma	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Bleeding from the vessels of the cord with extravasation of blood into the Wharton jelly surrounding the umbilical cord vessels.
http://purl.obolibrary.org/obo/HP_0030658	Marginal umbilical cord insertion	http://purl.obolibrary.org/obo/HP_0011418	Abnormal insertion of umbilical cord		Insertion of the umbilical cord within 2 cm from the placental edge.
http://purl.obolibrary.org/obo/HP_0030659	Velamentous cord insertion	http://purl.obolibrary.org/obo/HP_0011418	Abnormal insertion of umbilical cord		Insertion of the umbilical cord into the chorio-amniotic membranes of the placenta.
http://purl.obolibrary.org/obo/HP_0030660	Furcate cord insertion	http://purl.obolibrary.org/obo/HP_0011418	Abnormal insertion of umbilical cord		Branching of the umbilical cord before its insertion into the placenta.
http://purl.obolibrary.org/obo/HP_0030661	Vitreous snowballs	http://purl.obolibrary.org/obo/HP_0011531	Vitritis		Yellow-white inflammatory aggregates in the vitreous that are found in the midvitreous and inferior periphery.
http://purl.obolibrary.org/obo/HP_0030662	Vitreous inflammatory cells	http://purl.obolibrary.org/obo/HP_0011531	Vitritis		The presence of inflammatory cells such as lymphocytes and macrophages in the vitreous.
http://purl.obolibrary.org/obo/HP_0030663	Optically empty vitreous	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Vestigial vitreous gel occupying the immediate retrolental space and minimal to no discernible gel in the central vitreous cavity, giving the appearance of an empty vitreous cavity.
http://purl.obolibrary.org/obo/HP_0030664	Beevor's sign	http://purl.obolibrary.org/obo/HP_0009023	Abdominal wall muscle weakness		Weakness of the inferior portion of the rectus abdominal muscle, which is ascertained clinically as follows. When a patient sits up or raises the head from a recumbent position, the umbilicus is displaced toward the head. This is the result of paralysis of the inferior portion of the rectus abdominal muscle, so that the upper fibers predominate pulling upwards the umbilicus.
http://purl.obolibrary.org/obo/HP_0030665	Rubral tremor	http://purl.obolibrary.org/obo/HP_0001337	Tremor		Rubral tremor is characterized by a slow coarse tremor at rest that is exacerbated by postural adjustments and by guided voluntary movements.
http://purl.obolibrary.org/obo/HP_0030667	Peripheral retinal neovascularization	http://purl.obolibrary.org/obo/HP_0030666	Retinal neovascularization		A type of retinal neovascularization that affects the periphery of the retina.
http://purl.obolibrary.org/obo/HP_0030668	Periorbital dermoid cyst	http://purl.obolibrary.org/obo/HP_0001144	Orbital cyst		A cyst that is localized in the region of the orbit and exhibits an epithelial lining with a keratin-filled lumen. Hair follicles are one of the adnexal structures that are commonly found in walls of dermoid cysts.
http://purl.obolibrary.org/obo/HP_0030671	Abnormal common tendinous ring morphology	http://purl.obolibrary.org/obo/HP_0030669	Abnormal ocular adnexa morphology		Any anomaly of the ring of fibrous tissue that surrounds the optic nerve at its entrance at the apex of the orbit. The common tendinous ring, also known as the annulus of Zinn or annular tendon, is the origin for five of the seven extraocular muscles.
http://purl.obolibrary.org/obo/HP_0030672	Asteroid hyalosis	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		The presence of small, white vitreous opacities consisting of calcium phosphate and complex, layered lipid deposits.
http://purl.obolibrary.org/obo/HP_0030673	Erosive vitreoretinopathy	http://purl.obolibrary.org/obo/HP_0007773	Vitreoretinopathy		A form of vitreoretinopathy characterized by thinning (erosion) of the retinal pigment epithelium that permits increased visualization of the choroidal vessels.
http://purl.obolibrary.org/obo/HP_0030675	Contracture of proximal interphalangeal joints of 2nd-5th fingers	http://purl.obolibrary.org/obo/HP_0001215	Camptodactyly of 2nd-5th fingers		Chronic loss of joint motion of the proximal interphalangeal joint of the 2nd, 3rd, 4th, and 5th fingers due to structural changes in non-bony tissue.
http://purl.obolibrary.org/obo/HP_0030676	Satyr ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Sharp pointed superior portion of the ear, with variable overfolding of the helix.
http://purl.obolibrary.org/obo/HP_0030677	Mozart ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		A congenital auricular deformity, which is mainly characterized by a bulging appearance of the anterosuperior portion of the auricle, a convexly protruded cavum conchae, and a slit-like narrowing of the orifice of the external auditory meatus.
http://purl.obolibrary.org/obo/HP_0030679	Ash-leaf spot	http://purl.obolibrary.org/obo/HP_0009719	Hypomelanotic macule		A hypopigmented spot in the shape of a leaf from the mountain ash tree.
http://purl.obolibrary.org/obo/HP_0030681	Abnormal morphology of myocardial trabeculae	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Any structural anomaly of the muscular columns which project from the inner surface of the right and left ventricles of the heart (cardiac trabeculae, trabeculae carneae).
http://purl.obolibrary.org/obo/HP_0030682	Left ventricular noncompaction	http://purl.obolibrary.org/obo/HP_0031192	Abnormal morphology of left ventricular trabeculae		Left ventricular noncompaction (LVNC) is defined by 3 markers: prominent left ventricular (LV) trabeculae, deep intertrabecular recesses, and the thin compacted layer.
http://purl.obolibrary.org/obo/HP_0030683	Recurrent bacterial vaginosis	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Repeated symptomatic episodes of inflammation of the vagina that can result from a spectrum of conditions that cause vaginal and sometimes vulvar symptoms, such as itching, burning, irritation, odor, and vaginal discharge.
http://purl.obolibrary.org/obo/HP_0030684	Abnormal adiponectin level	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		A deviation from the normal circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue, and that plays a crucial role in the regulation of insulin sensitivity and glucose metabolism.
http://purl.obolibrary.org/obo/HP_0030685	Decreased adiponectin level	http://purl.obolibrary.org/obo/HP_0030684	Abnormal adiponectin level		A reduced circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue.
http://purl.obolibrary.org/obo/HP_0030686	Increased adiponectin level	http://purl.obolibrary.org/obo/HP_0030684	Abnormal adiponectin level		An elevated circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue.
http://purl.obolibrary.org/obo/HP_0030687	Abnormal circulating glucagon concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		A deviation from the normal concentration of glucagon in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030688	Increased glucagon level	http://purl.obolibrary.org/obo/HP_0030687	Abnormal circulating glucagon concentration		An elevated concentration of glucagon in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030689	Decreased glucagon level	http://purl.obolibrary.org/obo/HP_0030687	Abnormal circulating glucagon concentration		A reduced concentration of glucagon in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030690	Gingival cleft	http://purl.obolibrary.org/obo/HP_0000168	Abnormality of the gingiva		A fissure in the gingiva (gums), i.e., the mucosal tissue that lies over the mandible and maxilla.
http://purl.obolibrary.org/obo/HP_0030691	Divergence nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		A condition in which both eyes beat outward simultaneously.
http://purl.obolibrary.org/obo/HP_0030692	Brain neoplasm	http://purl.obolibrary.org/obo/HP_0100006	Neoplasm of the central nervous system		A benign or malignant neoplasm that arises from or metastasizes to the brain.
http://purl.obolibrary.org/obo/HP_0030706	Ranula	http://purl.obolibrary.org/obo/HP_0010286	Abnormal salivary gland morphology		A ranula is a mucocele that occurs in the floor of the mouth and usually involve the major salivary glands. Specifically, the ranula originates in the body of the sublingual gland, in the ducts of the sublingual gland, in the Wharton's duct of the submandibular gland or infrequently from the minor salivary glands at this location.
http://purl.obolibrary.org/obo/HP_0030707	Unilateral lung agenesis	http://purl.obolibrary.org/obo/HP_0006703	Aplasia/Hypoplasia of the lungs		Lack of development of one lung.
http://purl.obolibrary.org/obo/HP_0030708	Myeloschisis	http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect		The severe form of a neural tube defect where the open neural tube appears as a flattened, plate-like mass of nervous tissue with no overlying membrane.
http://purl.obolibrary.org/obo/HP_0030709	Myelocystocele	http://purl.obolibrary.org/obo/HP_0002196	Myelopathy		Myelocystocele is characterized by a large, ependyma-lined, cystic dilation of the caudal end of the central canal of the spinal cord; it projects dorsally through a lamina defect, with overlying varying amounts of lipomatous subcutaneous tissue. Myelocystoceles are associated with a tethered cord and meningocele, which communicates with the spinal subarachnoid space, but not with the central canal cyst.
http://purl.obolibrary.org/obo/HP_0030710	Lipomeningocele	http://purl.obolibrary.org/obo/HP_0002435	Meningocele		A form of closed neural tube defect in which the spinal tissue lies within the spinal cord having a junction between the spinal cord and the lipoma. Intact skin covers the defect. Neurologic findings first appear during the second year of life.
http://purl.obolibrary.org/obo/HP_0030711	Hydrocolpos	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		Distention of the vagina caused by accumulation of fluid due to congenital vaginal obstruction.
http://purl.obolibrary.org/obo/HP_0030712	Uterine synechiae	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		Adhesions or scar tissue that form inside the cavity of the uterus.
http://purl.obolibrary.org/obo/HP_0030713	Vein of Galen aneurysmal malformation	http://purl.obolibrary.org/obo/HP_0012480	Abnormal cerebral vein morphology		Vein of Galen aneurysmal malformation is a choroidal type of arteriovenous malformation that develops between 6 and 11 weeks of gestation. It results from 1 or more arteriovenous fistulas shunting blood toward the prosencephalic vein of Markowski, the embryonic precursor of the vein of Galen. This abnormal shunt leads to progressive dilation of the vein and prevents its involution and subsequent development into the vein of Galen.
http://purl.obolibrary.org/obo/HP_0030714	Subchorionic thrombohematoma	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		A large maternal clot that separates the chorionic plate from the villous chorion.
http://purl.obolibrary.org/obo/HP_0030715	Bronchial atresia	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		A developmental anomaly characterized by focal obliteration of the proximal segment of a bronchus. The bronchial pattern is entirely normal distal to the site of stenosis.
http://purl.obolibrary.org/obo/HP_0030716	Acrania	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Partial or complete absence of the flat bones of the cranial vault. The condition is frequently, though not always, associated with anencephaly.
http://purl.obolibrary.org/obo/HP_0030717	Meconium peritonitis	http://purl.obolibrary.org/obo/HP_0002586	Peritonitis		Peritonitis caused by intrauterine intestinal rupture and spillage of fetal meconium into the fetal peritoneal cavity. Intra-peritoneal meconium usually calcifies, sometimes within 24 hours. Ultrasound findings may include intraabdominal calcifications.
http://purl.obolibrary.org/obo/HP_0030718	Right atrial enlargement	http://purl.obolibrary.org/obo/HP_0025580	Abnormal right atrium morphology		Increase in size of the right atrium.
http://purl.obolibrary.org/obo/HP_0030719	Unguarded tricuspid valve	http://purl.obolibrary.org/obo/HP_0011662	Tricuspid atresia		A form of agenesis of the tricuspid valve in which (although the normal orifice between the right atrium and right ventricle exists) there is no tricuspid valvular tissue.
http://purl.obolibrary.org/obo/HP_0030720	Subchorionic septal cyst	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Cyst on the surface of the placenta consisting of amnion and chorion.
http://purl.obolibrary.org/obo/HP_0030721	Tetraphocomelia	http://purl.obolibrary.org/obo/HP_0009829	Phocomelia		Phocomelia involving all four extremities.
http://purl.obolibrary.org/obo/HP_0030722	Ectopic liver	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Ectopic liver is a rare developmental anomaly in which liver tissue is situated outside the liver. Thus, ectopic liver refers to autonomous islands of normal liver parenchyma located outside the liver. The term ectopic liver is also used, to include liver appendices attached to the native liver by a thin stalk although being fully separated from the latter.
http://purl.obolibrary.org/obo/HP_0030723	Congenital megalourethra	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		Dilation and elongation of the penile urethra associated with absence or hypoplasia of the corpora spongiosa and cavernosa.
http://purl.obolibrary.org/obo/HP_0030725	Neurenteric cyst	http://purl.obolibrary.org/obo/HP_0030724	Central nervous system cyst		The neurenteric cyst is a rare lesion composed of heterotopic endodermal tissue. During the third week of human embryogenesis, the neurenteric canal unites the yolk sac and the amniotic cavity as it traverses the primitive notochordal plate. Persistence of the normally transient neurenteric canal prevents appropriate separation of endoderm and notochord. This results in a variable degree of communication between neural and enteric epithelium.
http://purl.obolibrary.org/obo/HP_0030726	Spinal neurenteric cyst	http://purl.obolibrary.org/obo/HP_0030725	Neurenteric cyst		A neurenteric cyst located in the spine.
http://purl.obolibrary.org/obo/HP_0030727	Intracranial neurenteric cyst	http://purl.obolibrary.org/obo/HP_0030725	Neurenteric cyst		A neurenteric cyst located within the skull.
http://purl.obolibrary.org/obo/HP_0030728	Meromelia	http://purl.obolibrary.org/obo/HP_0009826	Limb undergrowth		Partial absence of a free limb (excluding girdle). It can refer to the proximal, middle or distal segment of the upper or lower limb. The deficiency may be transverse or longitudinal. Thus, meromelia is a lack of a part, but not all, of one or more limbs with the presence of a hand or foot.
http://purl.obolibrary.org/obo/HP_0030729	Frontoethmoidal meningocele	http://purl.obolibrary.org/obo/HP_0002435	Meningocele		A herniation of meninges through a congenital bone defect in the skull at the junction of the frontal and ethmoidal bones.
http://purl.obolibrary.org/obo/HP_0030730	Parietal meningocele	http://purl.obolibrary.org/obo/HP_0002435	Meningocele		A herniation of meninges through a congenital bone defect in the skull in the parietal region.
http://purl.obolibrary.org/obo/HP_0030731	Carcinoma	http://purl.obolibrary.org/obo/HP_0031492	Epithelial neoplasm		A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus).
http://purl.obolibrary.org/obo/HP_0030732	Dysplastic tricuspid valve	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		A congenital malformation of the tricuspid valve characterized by leaflet deformation.
http://purl.obolibrary.org/obo/HP_0030733	Vesicoallantoic abdominal wall defect	http://purl.obolibrary.org/obo/HP_0010478	Abnormality of the urachus		An abdominal wall defected related to a developmental anomaly of the allantois, which is an embryonic structure that develops as a diverticulum off the yolk sac at about 16 days post fertilization. During further development, the allantois becomes incorporated into the body of the embryo, connecting the ventral aspect of the urogenital sinus (which will develop into the upper pole of the urinary bladder) to the external portion of the umbilicus. Upon further development, the lumen of the allantois becomes obliterated and forms a thick fibrous cord called the urachus, which connects the apex of the bladder to the umbilicus. In adults, the urachus is known as the median umbilical ligament. Failure of the allantoic cavity to obliterate can result of one of four conditions: 1) congenital patent urachus (a completely open connection between bladder and umbilicus); 2) vesicourachal diverticulum (a diverticulum off the bladder but not communicating with the umbilicus); umbilical cyst and sinus (not communicating with the bladder); and 4) alternating urachal sinus. An abdominal wall defect can be associated with a urachal cyst.
http://purl.obolibrary.org/obo/HP_0030735	Ureterovesical junction obstruction	http://purl.obolibrary.org/obo/HP_0006000	Ureteral obstruction		Blockage at the level of the bladder and the ureter caused by stenosis of the ureteral valves or failure of a narrow juxtavesical ureteral segment to dilate due to segmented fibrosis or localized absence of muscle.
http://purl.obolibrary.org/obo/HP_0030737	Altman type I sacrococcygeal teratoma	http://purl.obolibrary.org/obo/HP_0030736	Sacrococcygeal teratoma		A type of sacrococcygeal teratoma that is predominantly external and projects from the sacrococcygeal region and presents with distortion of the buttocks.
http://purl.obolibrary.org/obo/HP_0030738	Altman type II sacrococcygeal teratoma	http://purl.obolibrary.org/obo/HP_0030736	Sacrococcygeal teratoma		A type of sacrococcygeal teratoma that is predominantly external but has a large intrapelvic component.
http://purl.obolibrary.org/obo/HP_0030739	Altman type III sacrococcygeal teratoma	http://purl.obolibrary.org/obo/HP_0030736	Sacrococcygeal teratoma		A type of sacrococcygeal teratoma that is predominantly intrapelvic with a small external, buttock mass.
http://purl.obolibrary.org/obo/HP_0030740	Anomalous muscle bundle of the right ventricle	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		An accessory (not normally present) muscle bundle in the right ventricle which obstructs the right ventricular outflow tract.
http://purl.obolibrary.org/obo/HP_0030741	Mediastinal teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		A teratoma located within the mediastinum (the cavity between the pleural sacs that contains the heart and all of the thoracic viscera except the lungs).
http://purl.obolibrary.org/obo/HP_0030742	Glial remnants posterior to lens	http://purl.obolibrary.org/obo/HP_0007968	Remnants of the hyaloid vascular system		This anomaly, also known as Mittendorf dot, is a benign, nonprogressive recognizable lesion that does not cause visual impairment. However, it can resemble a pathological congenital or acquired cataract lesion which may enlarge and cause visual impairment. The dot appears as a black speck that ranges in size from the dot made by a sharp pencil point to the size of a poppy seed. It is usually well defined, although occasionally there may be irregular, fine lines radiating outward from the dot.
http://purl.obolibrary.org/obo/HP_0030743	Glial remnants anterior to the optic disc	http://purl.obolibrary.org/obo/HP_0007968	Remnants of the hyaloid vascular system		Persistence of a posterior remnant of the hyaloid artery located at the optic disc.
http://purl.obolibrary.org/obo/HP_0030744	Hyaloid vascular remnant and retrolental mass	http://purl.obolibrary.org/obo/HP_0007968	Remnants of the hyaloid vascular system		A type of persistence of the hyaloid vascular system associated with a retrolental mass that may lead to fetal cataract.
http://purl.obolibrary.org/obo/HP_0030745	Dilatation of the ductus arteriosus	http://purl.obolibrary.org/obo/HP_0011603	Congenital malformation of the great arteries		Ductus arteriosus aneurysm (DAA) is a saccular dilatation of the ductus arteriosus. DAA can be either congenital or acquired (e.g. as a complication of surgical closure of a patent ductus arteriosus). Although the majority of patients with congenital DAA are asymptomatic and have a benign course, severe complications, such as rupture or thromboembolism, can occur. DAA is likely to emerge in the third trimester from the aortic junction of the DA, extending towards its pulmonary end.
http://purl.obolibrary.org/obo/HP_0030746	Intraventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial hemorrhage		Bleeding into the ventricles of the brain.
http://purl.obolibrary.org/obo/HP_0030747	Preterm intraventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0030746	Intraventricular hemorrhage		Intraventricular hemorrhage that occurs in a premature infant.
http://purl.obolibrary.org/obo/HP_0030748	Grade I preterm intraventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0030747	Preterm intraventricular hemorrhage		Intraventricular hemorrhage that occurs in a preterm infant and that is restricted to subependymal region/germline matrix which is seen in the caudothalamic groove.
http://purl.obolibrary.org/obo/HP_0030749	Grade II preterm intraventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0030747	Preterm intraventricular hemorrhage		Intraventricular hemorrhage that occurs in a preterm infant and that has extension into normal-sized ventricles and typically fills less than 50% of the volume of the ventricle.
http://purl.obolibrary.org/obo/HP_0030750	Grade III preterm intraventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0030747	Preterm intraventricular hemorrhage		Intraventricular hemorrhage that occurs in a preterm infant and that has extension into dilated ventricles.
http://purl.obolibrary.org/obo/HP_0030751	Grade IV preterm intraventricular hemorrhage	http://purl.obolibrary.org/obo/HP_0030747	Preterm intraventricular hemorrhage		Intraventricular hemorrhage that occurs in a preterm infant and that shows parenchymal extension.
http://purl.obolibrary.org/obo/HP_0030752	Dacryocystocele	http://purl.obolibrary.org/obo/HP_0000579	Nasolacrimal duct obstruction		A nasolacrimal duct obstruction presenting as a grey-blue cystic swelling just below the medial canthus. Believed to be a result of concomitant upper obstruction of the Rosenmuller valve and lower obstruction of the Hasner valve.
http://purl.obolibrary.org/obo/HP_0030753	Intrauterine fetal demise of one twin after midgestation	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		Loss of one twin occurring after midgestation (17 weeks gestation).
http://purl.obolibrary.org/obo/HP_0030754	Allantoic cyst	http://purl.obolibrary.org/obo/HP_0010478	Abnormality of the urachus		A swelling formed at the base of umbilicus associated with a patent urachus which results from an allantoic remnant. The urachus is a fibrous remnant of the allantois which communicates from the apex of the urinary bladder to the umbilicus. Failed obliteration of the urachus can lead to various abnormalities: urachal cyst, urachal diverticulum, sinus or patent urachus - the most common type. Allantoic cysts in infants with patent urachus can be formed due to the drainage of urine into the umbilical cord, or in uncommon situations, after leakage of hypo-osmotic urine into the Wharton's jelly.
http://purl.obolibrary.org/obo/HP_0030755	Craniofacial teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		A teratoma located in the craniofacial region.
http://purl.obolibrary.org/obo/HP_0030756	Erythrodontia	http://purl.obolibrary.org/obo/HP_0011073	Abnormality of dental color		Reddish, brown opalescent discoloration of teeth in normal light.
http://purl.obolibrary.org/obo/HP_0030757	Tooth abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A pocket of pus located within a region of a tooth.
http://purl.obolibrary.org/obo/HP_0030758	Periapical tooth abscess	http://purl.obolibrary.org/obo/HP_0030757	Tooth abscess		A tooth abscess that occurs at the tip of the root (apex) of a tooth.
http://purl.obolibrary.org/obo/HP_0030759	Adipocyte hypertrophy	http://purl.obolibrary.org/obo/HP_0009124	Abnormal adipose tissue morphology		An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy.
http://purl.obolibrary.org/obo/HP_0030762	Mesangiolysis	http://purl.obolibrary.org/obo/HP_0033232	Abnormal glomerular mesangial matrix morphology		Partial or complete dissolution of the mesangial matrix, identified by reduced staining on a periodic acid-Schiff (PAS) or silver stain.
http://purl.obolibrary.org/obo/HP_0030763	Amniotic Sheet	http://purl.obolibrary.org/obo/HP_0011409	Abnormal placental membrane morphology		A sheet like projection that can result from uterine synechiae that has been encompassed by the expanding chorion and amnion.
http://purl.obolibrary.org/obo/HP_0030764	Ochronosis	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Brown or blue-gray discoloration of the skin that can present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. The sclerae are also typically involved.
http://purl.obolibrary.org/obo/HP_0030765	Sleep terror	http://purl.obolibrary.org/obo/HP_0025184	Arousal parasomnia		Autonomic arousal, screaming, sweating, crying, outbursts during sleep, usually no recollection at the individual level; typically observed by others.
http://purl.obolibrary.org/obo/HP_0030766	Ear pain	http://purl.obolibrary.org/obo/HP_0046506	Pain in head and neck region		Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia).
http://purl.obolibrary.org/obo/HP_0030767	Epignathus	http://purl.obolibrary.org/obo/HP_0100649	Neoplasm of the oral cavity		Epignathus is a teratoma originating from the upper jaw, usually connected with the sphenoid bone or hard palate.
http://purl.obolibrary.org/obo/HP_0030769	Exencephaly	http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect		A malformation of the neural tube with a large amount of protruding brain tissue and absence of calvarium.
http://purl.obolibrary.org/obo/HP_0030770	Craniorachischisis	http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect		A neural tube defect in which both the brain and spinal cord remain open to varying degrees.
http://purl.obolibrary.org/obo/HP_0030771	Mallet finger	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Mallet finger refers to a condition in which the end joint of a finger bends but will not straighten by itself. In this situation, the joint can be pushed straight but will not hold that position on its own.
http://purl.obolibrary.org/obo/HP_0030772	Proximal femoral focal deficiency	http://purl.obolibrary.org/obo/HP_0005613	Aplasia/hypoplasia of the femur		Proximal femoral focal deficiency is a deformity manifested by hypoplasia of a variable portion of the femur with shortening of the entire limb.
http://purl.obolibrary.org/obo/HP_0030773	Internuclear ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000602	Ophthalmoplegia		An abnormality of conjugate lateral gaze in which the affected eye shows impairment of adduction. The pathognomonic clinical sign of internuclear ophthalmoplegia is an impaired adduction while testing horizontal saccades on the side of the lesion in the ipsilateral medial longitudinal fascicule.
http://purl.obolibrary.org/obo/HP_0030774	Mitochondrial swelling	http://purl.obolibrary.org/obo/HP_0012087	Abnormal mitochondrial shape		The mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures.
http://purl.obolibrary.org/obo/HP_0030775	Modic type vertebral endplate changes	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		An abnormal magnetic resonance tomography signal from a vertebral endplate according to a widely used classification published by Dr. Michael Modic.
http://purl.obolibrary.org/obo/HP_0030776	Modic type I vertebral endplate changes	http://purl.obolibrary.org/obo/HP_0030775	Modic type vertebral endplate changes		An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1-weighted sequences and high signal on T2-weighted sequences. Modic type I changes are thought to represent bone marrow edema and inflammation.
http://purl.obolibrary.org/obo/HP_0030777	Modic type II vertebral endplate changes	http://purl.obolibrary.org/obo/HP_0030775	Modic type vertebral endplate changes		An abnormal magnetic resonance tomography signal from a vertebral endplate with a high signal on T1-weighted sequences and high- or isointense signal on T2 sequences. Modic type II signals are thought to indicate fatty replacement in the bone marrow.
http://purl.obolibrary.org/obo/HP_0030778	Modic type III vertebral endplate changes	http://purl.obolibrary.org/obo/HP_0030775	Modic type vertebral endplate changes		An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1 and T2-weighted sequences. Modic type III signals are thought to correspond to subchondral sclerosis seen on plain radiographs.
http://purl.obolibrary.org/obo/HP_0030779	Ethmocephaly	http://purl.obolibrary.org/obo/HP_0001360	Holoprosencephaly		Ethmocephaly is the rarest form of holoprosencephaly, which occurs due to an incomplete cleavage of the forebrain. Clinically, the disease presents with a proboscis, hypotelorism, microphthalmos and malformed ears.
http://purl.obolibrary.org/obo/HP_0030781	Increased circulating free fatty acid level	http://purl.obolibrary.org/obo/HP_0040300	Abnormal circulating free fatty acid concentration		A higher than normal levels of the fatty acids which can occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues.
http://purl.obolibrary.org/obo/HP_0030783	Increased circulating interleukin 6 concentration	http://purl.obolibrary.org/obo/HP_6000441	Abnormal circulating interleukin 6 concentration		The concentration of interleukin-6 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0030784	Anomic aphasia	http://purl.obolibrary.org/obo/HP_0002381	Aphasia		An inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name.
http://purl.obolibrary.org/obo/HP_0030785	Mediastinal cystic lymphangioma	http://purl.obolibrary.org/obo/HP_0100764	Lymphangioma		A lymphangioma (congenital malformation consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures) located within the mediastinum, i.e., the central compartment of the thoracic cavity that is surrounded by loose connective tissue. Mediastinal lymphangioma is a slow growing mass with benign features, and accounts for 1% of all mediastinal tumors.
http://purl.obolibrary.org/obo/HP_0030786	Photopsia	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Perceived flashes of light.
http://purl.obolibrary.org/obo/HP_0030787	Cerumen abnormality	http://purl.obolibrary.org/obo/HP_0000372	Abnormal auditory canal morphology		Any anomaly of the cerumen (ear wax), the yellowish waxy substance secreted in the ear canal.
http://purl.obolibrary.org/obo/HP_0030788	Impacted cerumen	http://purl.obolibrary.org/obo/HP_0030787	Cerumen abnormality		Blockage of the external auditory canal by a buildup of earwax.
http://purl.obolibrary.org/obo/HP_0030789	Excessive cerumen	http://purl.obolibrary.org/obo/HP_0030787	Cerumen abnormality		An increased quantity of earwax.
http://purl.obolibrary.org/obo/HP_0030790	Abnormal cerumen color	http://purl.obolibrary.org/obo/HP_0030787	Cerumen abnormality		An anomalous earwax color. Earwax (cerumen) is usually light to dark brown or orange in color.
http://purl.obolibrary.org/obo/HP_0030792	Jaw neoplasm	http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology		A tumor originating in the jaw (mandible or maxilla).
http://purl.obolibrary.org/obo/HP_0030793	Jaw swelling	http://purl.obolibrary.org/obo/HP_0030791	Abnormal jaw morphology		Abnormal enlargement in the upper jaw (maxilla) or in the lower jaw (mandible).
http://purl.obolibrary.org/obo/HP_0030794	Abnormal circulating C-peptide concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of C-peptide in the blood circulation.
http://purl.obolibrary.org/obo/HP_0030795	Decreased circulating C-peptide concentration	http://purl.obolibrary.org/obo/HP_0030794	Abnormal circulating C-peptide concentration		The concentration of C-peptide in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0030796	Elevated circulating C-peptide concentration	http://purl.obolibrary.org/obo/HP_0030794	Abnormal circulating C-peptide concentration		The concentration of C-peptide in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0030797	Reduced volume of central subdivision of bed nucleus of stria terminalis	http://purl.obolibrary.org/obo/HP_0030798	Abnormality of the bed nucleus of stria terminalis		A diminished volume of the central part of the bed nucleus of the stria terminalis.
http://purl.obolibrary.org/obo/HP_0030798	Abnormality of the bed nucleus of stria terminalis	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		The stria terminalis is a slender, compact fiber bundle that connects the amygdala (amygdaloid body) with the hypothalamus and other basal forebrain regions. The bed nucleus of the stria terminalis is a limbic forebrain structure that receives heavy projections from, among other areas, the basolateral amygdala, and projects in turn to hypothalamic and brainstem target areas that mediate many of the autonomic and behavioral responses to aversive or threatening stimuli. This term refers to an anomaly of the bed nucleus.
http://purl.obolibrary.org/obo/HP_0030799	Scaphocephaly	http://purl.obolibrary.org/obo/HP_0000268	Dolichocephaly		Scaphocephaly is a subtype of dolichocephaly where the anterior and posterior aspects of the cranial vault are pointed (boat-shaped). Scaphocephaly is caused by a precocious fusion of sagittal suture without other associated synostosis.
http://purl.obolibrary.org/obo/HP_0030800	Abnormal visual accommodation	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		An anomaly in the process of visual accommodation, which is the process of adjustment of the eye to enable sharp vision of objects at different distances. Accommodation is mediated by contraction of the ciliary muscles, which alter the convexity of the lens and, consequently, its refractive power.
http://purl.obolibrary.org/obo/HP_0030801	Reduced visual accommodation	http://purl.obolibrary.org/obo/HP_0030800	Abnormal visual accommodation		A decreased ability of the eye to adjust and thereby enable sharp vision of objects at different distances.
http://purl.obolibrary.org/obo/HP_0030802	Lower eyelid retraction	http://purl.obolibrary.org/obo/HP_0500043	Eyelid retraction		Inferior malposition of the lower eyelid margin without eyelid eversion.
http://purl.obolibrary.org/obo/HP_0030803	Platonychia	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		Abnormal flat nail.
http://purl.obolibrary.org/obo/HP_0030804	Trachyonychia	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		Excessive longitudinal ridging that gives the surface of the nail plate a rough appearance. It results from multiple foci of defective keratinization of the proximal nail matrix.
http://purl.obolibrary.org/obo/HP_0030805	Absent lunula	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		Lack of the lunula at the base of a nail. The lunula is the crescent-shaped whitish area of the bed of a fingernail or toenail.
http://purl.obolibrary.org/obo/HP_0030806	Fast-growing nails	http://purl.obolibrary.org/obo/HP_0030807	Abnormal nail growth		Nails whose growth is quicker than normal.
http://purl.obolibrary.org/obo/HP_0030808	Ragged cuticle	http://purl.obolibrary.org/obo/HP_0025755	Abnormal nail shape		The cuticle (properly known as the eponychium, or the medial nail fold or the proximal nail fold), is the thickened layer of skin surrounding fingernails and toenails. Its function is to protect the area between the nail and epidermis from exposure to bacteria. This term refers to the presence of and irregular edge or outline of the cuticle.
http://purl.obolibrary.org/obo/HP_0030811	Tongue pain	http://purl.obolibrary.org/obo/HP_0046506	Pain in head and neck region		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the tongue.
http://purl.obolibrary.org/obo/HP_0030812	Enlarged tonsils	http://purl.obolibrary.org/obo/HP_0100765	Abnormality of the tonsils		Increase in size of the tonsils, small collections of lymphoid tissue facing into the aerodigestive tract on either side of the back part of the throat.
http://purl.obolibrary.org/obo/HP_0030813	Absent tonsils	http://purl.obolibrary.org/obo/HP_0100765	Abnormality of the tonsils		Lack of observable tonsillar tissue.
http://purl.obolibrary.org/obo/HP_0030814	Orange discolored tonsils	http://purl.obolibrary.org/obo/HP_0100765	Abnormality of the tonsils		A phenomenon of orange colored oral tonsils. This feature is characteristic of Tangier disease and illustrated will by Figure 1 of PMID:19470903.
http://purl.obolibrary.org/obo/HP_0030815	Lipoma of the tongue	http://purl.obolibrary.org/obo/HP_0100648	Neoplasm of the tongue		A lipoma localized to the tongue. May present as a nontender, soft, spherical mass of the tongue.
http://purl.obolibrary.org/obo/HP_0030816	Gingival recession	http://purl.obolibrary.org/obo/HP_0000168	Abnormality of the gingiva		The loss of gum tissue. The result is that gum tissue is recessed and its position on the tooth is lowered, exposing the roots of the teeth.
http://purl.obolibrary.org/obo/HP_0030817	Beaked nails	http://purl.obolibrary.org/obo/HP_0025755	Abnormal nail shape		Severe nail curvature, causing the tip of the nail to point downwards with respect to the axis of the finger. Beaked nails are caused by resorption of the distal digit.
http://purl.obolibrary.org/obo/HP_0030818	Central nail canal	http://purl.obolibrary.org/obo/HP_0008404	Nail dystrophy		The presence of a depressed line (canal) in the center of the nail.
http://purl.obolibrary.org/obo/HP_0030819	Ski jump nail	http://purl.obolibrary.org/obo/HP_0025755	Abnormal nail shape		Nails that slope upward at the free edge.
http://purl.obolibrary.org/obo/HP_0030820	Hooded eyelid	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Eyelid partly covered by skin when eyes are open.
http://purl.obolibrary.org/obo/HP_0030821	Hooded lower eyelid	http://purl.obolibrary.org/obo/HP_0030820	Hooded eyelid		Lower eyelid partly covered by skin when eyes are open.
http://purl.obolibrary.org/obo/HP_0030822	Hooded upper eyelid	http://purl.obolibrary.org/obo/HP_0030820	Hooded eyelid		Upper eyelid partly covered by skin when eyes are open.
http://purl.obolibrary.org/obo/HP_0030823	Scleral thickening	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		Increased dimension of the sclera in the anterior-posterior axis.
http://purl.obolibrary.org/obo/HP_0030824	Mizuo phenomenon	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Change in the color of the fundus from red in the dark-adapted state to golden immediately or shortly after the onset of the light. The color of the fundus reflex in the light adapted state has also been described as golden-yellow, gray-white, and yellow-white. This reflex can appear either homogeneous or in streaks in the fundus. The retinal vessels appear to be protruding in contrast to the radiant background. Dark adaptation leads to disappearance of the unusual fundus coloration [Digital Journal of Ophthalmology 2008; Volume 14, Number 14].
http://purl.obolibrary.org/obo/HP_0030825	Absent foveal reflex	http://purl.obolibrary.org/obo/HP_0000493	Abnormal foveal morphology		Absent reflectivity of the fovea, which normally is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope.
http://purl.obolibrary.org/obo/HP_0030826	Eyelid fasciculation	http://purl.obolibrary.org/obo/HP_0031785	Abnormal eyelid movement		Tiny, repetitive muscle contractions in the eyelids, causing the appearance of twitching.
http://purl.obolibrary.org/obo/HP_0030828	Wheezing	http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound		A high-pitched whistling sound associated with labored breathing.
http://purl.obolibrary.org/obo/HP_0030830	Crackles	http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound		Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position.
http://purl.obolibrary.org/obo/HP_0030831	Rhonchi	http://purl.obolibrary.org/obo/HP_0030829	Abnormal breath sound		Abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds.
http://purl.obolibrary.org/obo/HP_0030832	Vitreous strands	http://purl.obolibrary.org/obo/HP_0100832	Vitreous floaters		Fiber- or rope-like opacities located within the vitreous humor.
http://purl.obolibrary.org/obo/HP_0030833	Neck pain	http://purl.obolibrary.org/obo/HP_0046506	Pain in head and neck region		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the neck.
http://purl.obolibrary.org/obo/HP_0030834	Shoulder pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the shoulder.
http://purl.obolibrary.org/obo/HP_0030835	Elbow pain	http://purl.obolibrary.org/obo/HP_0012513	Upper limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the elbow.
http://purl.obolibrary.org/obo/HP_0030836	Wrist pain	http://purl.obolibrary.org/obo/HP_0012513	Upper limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the wrist.
http://purl.obolibrary.org/obo/HP_0030837	Finger pain	http://purl.obolibrary.org/obo/HP_0046505	Hand pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the finger.
http://purl.obolibrary.org/obo/HP_0030838	Hip pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip.
http://purl.obolibrary.org/obo/HP_0030839	Knee pain	http://purl.obolibrary.org/obo/HP_0012514	Lower limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee.
http://purl.obolibrary.org/obo/HP_0030840	Ankle pain	http://purl.obolibrary.org/obo/HP_0012514	Lower limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ankle.
http://purl.obolibrary.org/obo/HP_0030841	Toe pain	http://purl.obolibrary.org/obo/HP_0012514	Lower limb pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the toe.
http://purl.obolibrary.org/obo/HP_0030842	Choking episodes	http://purl.obolibrary.org/obo/HP_0100738	Abnormal eating behavior		Incidents in which a piece of food or other objects get stuck in the upper airway and provoke coughing, gagging, inability to talk, and difficulty breathing.
http://purl.obolibrary.org/obo/HP_0030843	Cardiac amyloidosis	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Extracellular deposition in cardiac tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding.
http://purl.obolibrary.org/obo/HP_0030844	Undetectable pattern electroretinogram	http://purl.obolibrary.org/obo/HP_0030467	Abnormal pattern electroretinogram		Absent response to a pattern electroretinogram (PERG).
http://purl.obolibrary.org/obo/HP_0030845	Heliotrope rash of eyelid	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Heliotrope rash is a violaceous discoloration of the eyelids associated with periorbital edema.
http://purl.obolibrary.org/obo/HP_0030846	Abnormality of venous physiology	http://purl.obolibrary.org/obo/HP_0030163	Abnormal vascular physiology		An anomaly of venous function.
http://purl.obolibrary.org/obo/HP_0030847	Abnormal jugular venous pressure	http://purl.obolibrary.org/obo/HP_0030846	Abnormality of venous physiology		An anomaly of the jugular venous pressure. The internal jugular veins, being continuous with the superior vena cava, provide a visible measure of the degree to which the systemic venous reservoir is filled. The vertical height above the right atrium to which they are distended and above which they are in a collapsed state provides an imperfect reflection of the right atrial pressure.
http://purl.obolibrary.org/obo/HP_0030848	Elevated jugular venous pressure	http://purl.obolibrary.org/obo/HP_0030847	Abnormal jugular venous pressure		Increased jugular venous pressure.
http://purl.obolibrary.org/obo/HP_0030849	Hepatojugular reflux	http://purl.obolibrary.org/obo/HP_0030847	Abnormal jugular venous pressure		The examiner applies firm but persistent pressure over the liver for 10 seconds while observing the mean jugular venous pressure. Normally there is either no rise or only a transient (i.e., 2 to 3 sec) rise in mean jugular venous pressure. A sustained increase in the mean venous pressure until abdominal compression is released is abnormal and indicates impaired right heart function. This abnormal response is called hepatojugular reflux.
http://purl.obolibrary.org/obo/HP_0030850	Abnormal pulse pressure	http://purl.obolibrary.org/obo/HP_0030163	Abnormal vascular physiology		An anomaly of the pulse pressure, which is defined as the systolic pressured minus the diastolic pressure.
http://purl.obolibrary.org/obo/HP_0030851	Low pulse pressure	http://purl.obolibrary.org/obo/HP_0030850	Abnormal pulse pressure		Reduced amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure).
http://purl.obolibrary.org/obo/HP_0030852	High pulse pressure	http://purl.obolibrary.org/obo/HP_0030850	Abnormal pulse pressure		Increased amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure).
http://purl.obolibrary.org/obo/HP_0030854	Scleral staphyloma	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		A staphyloma is a localized defect in the eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure.
http://purl.obolibrary.org/obo/HP_0030855	Anterior staphyloma	http://purl.obolibrary.org/obo/HP_0030854	Scleral staphyloma		A localized defect in the anterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure.
http://purl.obolibrary.org/obo/HP_0030856	Posterior staphyloma	http://purl.obolibrary.org/obo/HP_0030854	Scleral staphyloma		A localized defect in the posterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure.
http://purl.obolibrary.org/obo/HP_0030857	Eye movement-induced pain	http://purl.obolibrary.org/obo/HP_0200026	Ocular pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye that is worse in certain directions of gaze and during prolonged gaze holding.
http://purl.obolibrary.org/obo/HP_0030858	Addictive behavior	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		When an activity, substance, object, or behavior becomes a major focus of a person's life, excluding other activities, or has begun to harm the individual or others physically, mentally, or socially, it can be considered addictive behavior. A person can become addicted or compulsively engaged with anything.
http://purl.obolibrary.org/obo/HP_0030859	Anti-topoisomerase I antibody positivity	http://purl.obolibrary.org/obo/HP_0033476	Extractable nuclear antigen positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against topoisomerase I.
http://purl.obolibrary.org/obo/HP_0030860	Abnormal CSF amyloid concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Abnormal concentration of amyloid in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0030861	Decreased CSF amyloid concentration	http://purl.obolibrary.org/obo/HP_0030860	Abnormal CSF amyloid concentration		Reduced concentration of amyloid in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0030862	Elevated CSF amyloid concentration	http://purl.obolibrary.org/obo/HP_0030860	Abnormal CSF amyloid concentration		Increased concentration of amyloid in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0030863	Nasal flaring	http://purl.obolibrary.org/obo/HP_0002098	Respiratory distress		Widening of the nostrils upon inhalation as a manifestation of respiratory distress.
http://purl.obolibrary.org/obo/HP_0030864	Intercostal retractions	http://purl.obolibrary.org/obo/HP_0002098	Respiratory distress		A pulling inward of the soft tissues between the ribs upon inhalation. This is a sign of increased use of the chest muscles for breathing and is a manifestation of respiratory distress.
http://purl.obolibrary.org/obo/HP_0030865	Large elbow	http://purl.obolibrary.org/obo/HP_0020300	Abnormal elbow morphology		Abnormal increased size of the elbow joint.
http://purl.obolibrary.org/obo/HP_0030866	Large knee	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		Abnormally increased size of the knee joint.
http://purl.obolibrary.org/obo/HP_0030867	Vertical orbital dystopia	http://purl.obolibrary.org/obo/HP_0100886	Abnormality of globe location		The orbits do not lie on the same horizontal plane, that is, one eye is lower than the other.
http://purl.obolibrary.org/obo/HP_0030868	Monorchism	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Having only one testis in the scrotum.
http://purl.obolibrary.org/obo/HP_0030869	Anorchism	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		An abnormality of XY sexual development characterized by the absence of both testes at birth.
http://purl.obolibrary.org/obo/HP_0030871	Facet joint arthrosis	http://purl.obolibrary.org/obo/HP_0030870	Abnormality of spinal facet joint		Osteoarthritis of facet joints in the spine. Degeneration of cartilage in the facet joints results in bone rubbing on bone and reactive new bone formation visible on X-ray.
http://purl.obolibrary.org/obo/HP_0030873	Anti-centromere antibody positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against the centromeres or centromere components.
http://purl.obolibrary.org/obo/HP_0030874	Oxygen desaturation on exertion	http://purl.obolibrary.org/obo/HP_0012418	Hypoxemia		Oxygen saturation less than 95% on exertion or arterial partial pressure of oxygen falling by more than 1kPa.
http://purl.obolibrary.org/obo/HP_0030876	Increased pulmonary capillary wedge pressure	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		Pulmonary capillary wedge pressure (PCWP) above 15mmHg.
http://purl.obolibrary.org/obo/HP_0030877	Reduced FEV1/FVC ratio	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		Abnormally low FEV1/FVC (FEV1 - forced expiratory volume in 1 second; FVC forced vital capacity).
http://purl.obolibrary.org/obo/HP_0030879	Interlobular septal thickening	http://purl.obolibrary.org/obo/HP_0033711	Pulmonary interstitial thickening		Presence of thickening of the interlobular septa of the lungs as seen on a CT scan.
http://purl.obolibrary.org/obo/HP_0030881	Shoulder impingement	http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology		Trapping and compression of the rotator cuff tendons during shoulder movements.
http://purl.obolibrary.org/obo/HP_0030882	Coronary artery aneurysm	http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology		Enlargement of the diameter (cross-section) of a coronary artery as defined by a focal dilation of a segment at least 1.5 times larger than the reference vessel.
http://purl.obolibrary.org/obo/HP_0030883	Femoroacetabular impingement	http://purl.obolibrary.org/obo/HP_0001384	Abnormal hip joint morphology		Femoroacetabular impingement (FAI) results from one or more bony abnormalities that lead to abnormal contact between the acetabulum and the femoral head or neck. The femoral abnormality is proposed to cause compression and shear stresses in the region between the labrum and cartilage, anterosuperiorly. These stresses cause a separation between the labrum and cartilage as the labrum is pushed outwards and the cartilage is pushed centrally. This eventually leads to articular degeneration and eventually global hip osteoarthritis.
http://purl.obolibrary.org/obo/HP_0030884	Gastrojejunal tube feeding in infancy	http://purl.obolibrary.org/obo/HP_0008872	Feeding difficulties in infancy		Feeding problem necessitating gastrojejunal tube feeding.
http://purl.obolibrary.org/obo/HP_0030885	Recurrent parasitic infections	http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection		Increased susceptibility to parasitic infections as manifested by recurrent episodes of parasitic infection.
http://purl.obolibrary.org/obo/HP_0030887	Increased T cell apoptosis	http://purl.obolibrary.org/obo/HP_0030886	Abnormal T cell apoptosis		Abnormal increase of apoptosis by peripheral blood T cells in an in vitro culture, compared to a healthy control sample. May be either spontaneous, induced by UV, X-ray, FasL or other agens. Commonly measured by surface expression of phosphatidyl serine labelled by Annexin V, but other methods such as staning of cleaved Caspases may be used by different laboratories.
http://purl.obolibrary.org/obo/HP_0030888	C3 nephritic factor positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against C3 convertase (C3bBb).
http://purl.obolibrary.org/obo/HP_0030889	Congenital shortened small intestine	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		Substantially shortened length of the small intestine as a result of a developmental defect.
http://purl.obolibrary.org/obo/HP_0030890	Hyperintensity of cerebral white matter on MRI	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		A brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter.
http://purl.obolibrary.org/obo/HP_0030891	Periventricular white matter hyperintensities	http://purl.obolibrary.org/obo/HP_0030890	Hyperintensity of cerebral white matter on MRI		Areas of brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles.
http://purl.obolibrary.org/obo/HP_0030892	Deep cerebral white matter hyperintensities	http://purl.obolibrary.org/obo/HP_0030890	Hyperintensity of cerebral white matter on MRI		Areas of brighter than expected signal on magnetic resonance imaging emanating from locations distant from the ventricular system.
http://purl.obolibrary.org/obo/HP_0030893	Abnormal response to short acting pulmonary vasodilator	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		Pulmonary vasodilator testing is performed during right-heart catheterization and involves a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide. The current definition of a normal (positive) response is a drop in mean pulmonary artery pressure of at least 10 mm Hg (or 20 percent) to below 40 mm Hg.
http://purl.obolibrary.org/obo/HP_0030894	Insufficient response to short acting pulmonary vasodilator	http://purl.obolibrary.org/obo/HP_0030893	Abnormal response to short acting pulmonary vasodilator		No fall in mean pulmonary arterial pressure (mPAP) falls by at least 10 mmHg to an absolute value less than 40 mmHg without a degradation in cardiac output (CO) in response to a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide.
http://purl.obolibrary.org/obo/HP_0030896	Abnormal gastrointestinal transit time	http://purl.obolibrary.org/obo/HP_0030895	Abnormal gastrointestinal motility		A deviation from the normal amount of time required for food to pass through the intestines.
http://purl.obolibrary.org/obo/HP_0030897	Decreased intestinal transit time	http://purl.obolibrary.org/obo/HP_0030896	Abnormal gastrointestinal transit time		A reduction in the length of time required for food to pass through the intestines.
http://purl.obolibrary.org/obo/HP_0030898	Pruritis on abdomen	http://purl.obolibrary.org/obo/HP_0000989	Pruritus		Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the abdomen.
http://purl.obolibrary.org/obo/HP_0030899	Pruritis on hand	http://purl.obolibrary.org/obo/HP_0000989	Pruritus		Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the hand.
http://purl.obolibrary.org/obo/HP_0030900	Pruritus on foot	http://purl.obolibrary.org/obo/HP_0000989	Pruritus		Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the foot.
http://purl.obolibrary.org/obo/HP_0030901	Pruritis on breast	http://purl.obolibrary.org/obo/HP_0000989	Pruritus		Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the breast.
http://purl.obolibrary.org/obo/HP_0030902	Palmomental reflex	http://purl.obolibrary.org/obo/HP_0002476	Primitive reflex		A type of primitive reflex characterized by an involuntary contraction of the mentalis muscle of the chin caused by stimulation of the thenar eminence of the palm.
http://purl.obolibrary.org/obo/HP_0030903	Grasp reflex	http://purl.obolibrary.org/obo/HP_0002476	Primitive reflex		A type of primitive reflex that can be elicated when the hand of the examiner is gently inserted into the palm of the patient's hand. The palmar surface is stroked or simply touched. The flexor surfaces of the fingers may be stimulated also by the examiner's fingers. The stimulus should be in a distal direction. With a positive response, the patient grasps the examiner's hand with variable strength and continues to grasp as the examiner's hand is moved. Ability to release the grip voluntarily depends on the activity of the reflex; some patients can do so readily, while others can even be lifted off the bed, since the grasp has such power [NCBI Books:NBK395].
http://purl.obolibrary.org/obo/HP_0030904	Glabellar reflex	http://purl.obolibrary.org/obo/HP_0002476	Primitive reflex		A type of primitive reflex that is elicited by repetitive tapping on the forehead. Normal subjects usually blink in response to the first several taps, but if blinking persists, the response is abnormal and considered to be a sign of frontal release. Persistent blinking is also known as Myerson's sign.
http://purl.obolibrary.org/obo/HP_0030905	Snout reflex	http://purl.obolibrary.org/obo/HP_0002476	Primitive reflex		A type of primitive reflex that is elicited by tapping the upper lip lightly. The contraction of the muscles causes the mouth to resemble a snout.
http://purl.obolibrary.org/obo/HP_0030906	Suck reflex	http://purl.obolibrary.org/obo/HP_0002476	Primitive reflex		A type of primitive reflex that is elicited by lightly touching or tapping on the lips with an object such as a tongue blade, reflex hammer, or the examiner's finger. At times the reflex is obtained merely by approaching the lips with an object. A positive suck reflex consists of sucking movements by the lips when they are stroked or touched.
http://purl.obolibrary.org/obo/HP_0030907	Thunderclap headache	http://purl.obolibrary.org/obo/HP_0002315	Headache		Severe head pain with sudden onset, reaching its maximum intensity in less than one minute and lasting from one hour to ten days.
http://purl.obolibrary.org/obo/HP_0030908	Liver kidney microsome type 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against P450 2D6, a cytochrome P450 mono-oxygenase. Anti-LKM-1 antibodies are considered to be a diagnostic marker of autoimmune hepatitis type 2 (AIH2).
http://purl.obolibrary.org/obo/HP_0030909	Anti-liver cytosolic antigen type 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against a 60-kd peptide contained in the liver cytosolic fraction.
http://purl.obolibrary.org/obo/HP_0030911	Bifid clitoris	http://purl.obolibrary.org/obo/HP_0000056	Abnormal clitoris morphology		Two clitorides located side by side.
http://purl.obolibrary.org/obo/HP_0030912	Duplicated clitoris	http://purl.obolibrary.org/obo/HP_0000056	Abnormal clitoris morphology		Supernumerary clitoris.
http://purl.obolibrary.org/obo/HP_0030913	Exaggerated rugosity of the labia majora	http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology		Marked rugae formation of the skin of the labia majora.
http://purl.obolibrary.org/obo/HP_0030914	Abnormal peristalsis	http://purl.obolibrary.org/obo/HP_0002579	Gastrointestinal dysmotility		An anomaly of the wave-like muscle contractions of the digestive tract.
http://purl.obolibrary.org/obo/HP_0030934	Oral erythroplakia	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		A velvety red but not ulcerated lesion of the oral mucosa. The texture may be roughened or normal, and the lesion is neither raised nor depressed.
http://purl.obolibrary.org/obo/HP_0030935	Abnormal intestinal smooth muscle morphology	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		A structural anomaly of the nonstriated, involuntary muscle tissue of the intestine.
http://purl.obolibrary.org/obo/HP_0030936	Abnormal layering of muscularis propria	http://purl.obolibrary.org/obo/HP_0030935	Abnormal intestinal smooth muscle morphology		Abnormal layering of the intestinal muscularis propria into three layers; (1) inner circular; (2) additional oblique; and (3) outer longitudinal layer.
http://purl.obolibrary.org/obo/HP_0030937	Fibrotic muscularis propria	http://purl.obolibrary.org/obo/HP_0030935	Abnormal intestinal smooth muscle morphology		The presence of excessive fibrous connective tissue in the muscularis propria of the intestine. Fibrosis is a reparative or reactive process.
http://purl.obolibrary.org/obo/HP_0030938	Enteric intraneuronal nuclear inclusion bodies	http://purl.obolibrary.org/obo/HP_0025029	Abnormal enteric neuron morphology		Aggregates of stainable substances (proteins) in the nuclei of enteric neurons.
http://purl.obolibrary.org/obo/HP_0030939	Palpebral thickening	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		An increased thickness of the eyelid not related to acute inflammation.
http://purl.obolibrary.org/obo/HP_0030943	Vulvodynia	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain in the vulvar area
http://purl.obolibrary.org/obo/HP_0030946	Conjunctival papillae	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Raised tissue masses located on the palpebral conjunctiva with a central vessel. Papillae are created by a focal infiltration of inflammatory cells.
http://purl.obolibrary.org/obo/HP_0030947	Conjunctival follicles	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Small, dome-shaped nodules without a prominent central vessel located on the conjunctiva. The lymphoid follicles are located in the subendothelial region of the conjunctiva. They consist of a germinal center that contains immature, proliferating lymphocytes, as well as a corona that contains mature lymphocytes and plasma cells.
http://purl.obolibrary.org/obo/HP_0030948	Elevated gamma-glutamyltransferase level	http://purl.obolibrary.org/obo/HP_0034444	Abnormal gamma-glutamyltransferase level		Increased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.
http://purl.obolibrary.org/obo/HP_0030950	Pulmonary venous hypertension	http://purl.obolibrary.org/obo/HP_0030875	Abnormality of pulmonary circulation		An abnormal increase in pressure in the pulmonary veins, usually as a result of left atrial hypertension.
http://purl.obolibrary.org/obo/HP_0030951	Skeletal muscle fibrosis	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Excessive formation of fibrous bands of scar tissue in between muscle fibers.
http://purl.obolibrary.org/obo/HP_0030952	Birdshot choroidal lesions	http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology		Multiple cream-yellow colored hypopigmented lesions typically located at the level of the outer choroid. They are between 50 and 1,500 micrometers in size with a characteristic nasal, radial distribution in the postequatorial fundus.
http://purl.obolibrary.org/obo/HP_0030953	Conjunctival hyperemia	http://purl.obolibrary.org/obo/HP_0025337	Red eye		Dilatation of the blood vessels of the conjunctiva leading to a red appearance of the sclera.
http://purl.obolibrary.org/obo/HP_0030955	Addictive alcohol use	http://purl.obolibrary.org/obo/HP_5200329	Problematic alcohol consumption		An addictive behavior is defined as drinking excessive amounts of alcohol over a prolonged period of time, having difficulty in reducing the amount of alcohol consumed, strongly desiring alcohol, and experiencing withdrawal symptoms when not drinking alcohol.
http://purl.obolibrary.org/obo/HP_0040009	Hyperparakeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		Histological term to illustrate the combined presence of parakeratosis and hyperkeratosis. Abnormal keratinization of the epidermal stratum corneum (horny layer) with increased keratin formation and preservation of the nuclei in the superficial cells.
http://purl.obolibrary.org/obo/HP_0040030	Chorioretinal hypopigmentation	http://purl.obolibrary.org/obo/HP_0007661	Abnormality of chorioretinal pigmentation		Focal or global or heterogeneous loss of choroidal and retinal pigment epithelium (RPE) pigmentation in the absence of atrophy.
http://purl.obolibrary.org/obo/HP_0040036	Onychogryphosis of fingernail	http://purl.obolibrary.org/obo/HP_0001805	Onychogryphosis		Thickened fingernails.
http://purl.obolibrary.org/obo/HP_0040040	Toenail onycholysis	http://purl.obolibrary.org/obo/HP_0008388	Abnormal toenail morphology		Painless and spontaneous separation of a toenail from the nail bed.
http://purl.obolibrary.org/obo/HP_0040082	Happy demeanor	http://purl.obolibrary.org/obo/HP_5200261	Abnormal demeanor		A conspicuously happy disposition, characterized by frequent smiling and laughing, which may be contextually inappropriate or unrelated to the situation.
http://purl.obolibrary.org/obo/HP_0040087	Abnormal circulating folate concentration	http://purl.obolibrary.org/obo/HP_0020350	Abnormal circulating vitamin concentration		Any deviation from the normal concentration of folate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0040089	Abnormal total natural killer cell count	http://purl.obolibrary.org/obo/HP_0012176	Abnormal natural killer cell morphology		Abnormal increase or decrease of total natural killer (NK) cells, commonly characterized as CD3-CD19- and CD16+ or CD56+ lymphocytes, in the blood, per microlitre, or altered NK cell phenotype, compared to a reference range for a given sex and age-group, measured ex vivo.
http://purl.obolibrary.org/obo/HP_0040090	Abnormal tympanic membrane morphology	http://purl.obolibrary.org/obo/HP_0000370	Abnormality of the middle ear		Any structural abnormality of the tympanic membrane
http://purl.obolibrary.org/obo/HP_0040097	Neoplasm of the ceruminal gland	http://purl.obolibrary.org/obo/HP_0040095	Neoplasm of the outer ear		A tumor (abnormal growth of tissue) of the ceruminal gland.
http://purl.obolibrary.org/obo/HP_0040103	Acquired stenosis of the external ear canal	http://purl.obolibrary.org/obo/HP_0000402	Stenosis of the external auditory canal		Stenosis or narrowing of the external ear canal (EAC) occurs lateral to the tympanic membrane resulting in a skin lined blind canal.
http://purl.obolibrary.org/obo/HP_0040104	Osseous stenosis of the external auditory canal	http://purl.obolibrary.org/obo/HP_0000402	Stenosis of the external auditory canal		A narrowing of the bony part of the ear canal, which can be congenital or acquired through causes like chronic infections, trauma, or radiation therapy.
http://purl.obolibrary.org/obo/HP_0040115	Abnormal Eustachian tube morphology	http://purl.obolibrary.org/obo/HP_0000370	Abnormality of the middle ear		A structural anomaly of the Eustachian tube (ET). The ET is a biomechanical valve between the nasopharynx and the middle ear. Physiologically, it controls the passive adaptation of the middle ear air pressure to the ambient air pressure primarily via direct muscular actions of the soft palate. In the closed state it protects the middle ear. Inadequate function of the ET causes middle ear ventilation disorders.
http://purl.obolibrary.org/obo/HP_0040127	Abnormal sweat homeostasis	http://purl.obolibrary.org/obo/HP_0012337	Abnormal homeostasis		An abnormality of the composition of sweat or the levels of its components.
http://purl.obolibrary.org/obo/HP_0040135	Abnormal transferrin saturation	http://purl.obolibrary.org/obo/HP_0011031	Abnormality of iron homeostasis		Any abnormality in the serum transferrin saturation, which is calculated by dividing the serum iron level by total iron-binding capacity.
http://purl.obolibrary.org/obo/HP_0040137	Comedonal acne	http://purl.obolibrary.org/obo/HP_0001061	Acne		A type of acne in which open and closed comedones comprise the majority of the lesions, with substantially fewer papules and pustules.
http://purl.obolibrary.org/obo/HP_0040138	Mucinous histiocytosis	http://purl.obolibrary.org/obo/HP_0100727	Histiocytosis		Multiple subcutaneous non-fragile and skin-coloured papules characterized by interstitial infiltrate of spindle and epithelioid histiocytes, and mucin. There are well circumscribed aggregates of epithelioid histiocytes and mucin in the upper and middle dermis,with the histiocytes arranged between collagen bundles and separated from the epidermis by a Grenz zone.
http://purl.obolibrary.org/obo/HP_0040139	Lipogranulomatosis	http://purl.obolibrary.org/obo/HP_0004356	Abnormality of lysosomal metabolism		Yellow nodules of lipoid material are deposited in the skin and mucosae. This gives rise to granulomatous reactions.
http://purl.obolibrary.org/obo/HP_0040142	Reduced circulating 5-oxoprolinase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity or concentration of 5-oxoprolinase in the blood circulation below the lower limit of normal. This enzyme catalyzes the reaction 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate.
http://purl.obolibrary.org/obo/HP_0040143	Dystopic os odontoideum	http://purl.obolibrary.org/obo/HP_0005667	Os odontoideum		Os odontoideum is classified into two anatomic types (orthotopic and dystopic). Os odontoideum is defined as an ossicle that consists of smooth and separate caudal portions of the odontoid process. With orthotopic os odontoideum, the ossicle moves with the anterior arch of the atlas, while the dystopic type consists of an ossicle near the basion, or one that is fused with the clivus
http://purl.obolibrary.org/obo/HP_0040144	L-2-hydroxyglutaric aciduria	http://purl.obolibrary.org/obo/HP_0032278	2-hydroxyglutarate aciduria		An increase in the level of L-2-hydroxyglutaric acid in the urine.
http://purl.obolibrary.org/obo/HP_0040145	Dicarboxylic acidemia	http://purl.obolibrary.org/obo/HP_0032368	Acidemia		The concentration of dicarboxylic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0040148	Cortical myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		Cortical myoclonus mainly affects the distal upper limbs and face, which reflects the largest cortical representations of these body areas. It is often focal, but may be multifocal, bilateral or generalized, as a consequence of intracortical and transcallosal spreading of abnormal activity. It typically occurs on voluntary action and may affect speech and gait. Cortical myoclonic jerks are stimulus sensitive, typically to touch, but sensitivity to visual stimuli is also described. Most patients with cortical myoclonus have both positive myoclonus and NM, occurring either independently or together as a complex of the two kinds of myoclonus. If cortical myoclonus is prolonged and lasts for hours, days or weeks, it is called epilepsia partials continua and is considered to be a rare form of focal epileptic status. Focal cortical myoclonus almost always points to an underlining lesion of the sensori-motor cortex, which produces hyperexcitability (e.g. vascular, inflammatory or neoplastic).
http://purl.obolibrary.org/obo/HP_0040149	Woolly scalp hair	http://purl.obolibrary.org/obo/HP_0002224	Woolly hair		The presence of wooly hair on the scalp. The term wooly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter.
http://purl.obolibrary.org/obo/HP_0040154	Acne inversa	http://purl.obolibrary.org/obo/HP_0001061	Acne		A chronic skin condition involving the inflammation of the apocrine sweat glands, forming pimple-like bumps known as abscesses.
http://purl.obolibrary.org/obo/HP_0040155	Elevated urinary 3-hydroxybutyric acid	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		An increased amount of 3-hydroxybutyric acid in the urine.
http://purl.obolibrary.org/obo/HP_0040162	Orthokeratosis	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		Formation of an anuclear keratin layer
http://purl.obolibrary.org/obo/HP_0040164	Lipomas of eyelids	http://purl.obolibrary.org/obo/HP_0012032	Lipoma		Fatty tumors on the eyelids.
http://purl.obolibrary.org/obo/HP_0040165	Periostitis	http://purl.obolibrary.org/obo/HP_0030313	Abnormal periosteum morphology		Inflammation of the periosteum
http://purl.obolibrary.org/obo/HP_0040175	Platelet-activating factor acetylhydrolase deficiency	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced level of platelet-activating factor acetylhydrolase.
http://purl.obolibrary.org/obo/HP_0040176	Abnormal circulating phospholipid concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		Any deviation from the normal concentration of a phospholipid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0040181	Chapped lip	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Cracking, fissuring, and peeling of the skin of the lips.
http://purl.obolibrary.org/obo/HP_0040182	Inappropriate sinus tachycardia	http://purl.obolibrary.org/obo/HP_0011703	Sinus tachycardia		Inappropriate sinus tachycardia is a nonparoxysmal tachyarrhythmia characterized by an increased resting heart rate (HR) and/or an exaggerated HR response to minimal exertion or a change in body posture. HR is constantly above the physiological range with no appropriate relation to metabolic or physiological demands.
http://purl.obolibrary.org/obo/HP_0040186	Maculopapular exanthema	http://purl.obolibrary.org/obo/HP_4000054	Exanthem		A skin rash that is characterized by diffuse cutaneous erythema with areas of skin elevation. It may evolve to vesicles or papules as part of a more severe clinical entity. Different degrees of angioedema with involvement of subcutaneous tissue may also appear.
http://purl.obolibrary.org/obo/HP_0040187	Neonatal sepsis	http://purl.obolibrary.org/obo/HP_0100806	Sepsis		Systemic inflammatory response to infection in newborn babies.
http://purl.obolibrary.org/obo/HP_0040189	Scaling skin	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Refers to the loss of the outer layer of the epidermis in large, scale-like flakes.
http://purl.obolibrary.org/obo/HP_0040192	APUdoma	http://purl.obolibrary.org/obo/HP_0100568	Neoplasm of the endocrine system		An endocrine tumor arising from an APUD cell.
http://purl.obolibrary.org/obo/HP_0040196	Mild microcephaly	http://purl.obolibrary.org/obo/HP_0040195	Decreased head circumference		Decreased occipito-frontal (head) circumference (OFC). For the microcephaly OFC must be between -3 SD and -2 SD compared to appropriate, age matched, normal standards (i.e. -3 SD <= OFC < -2 SD).
http://purl.obolibrary.org/obo/HP_0040197	Encephalomalacia	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		Encephalomalacia is the softening or loss of brain tissue after cerebral infarction, cerebral ischemia, infection, craniocerebral trauma, or other injury.
http://purl.obolibrary.org/obo/HP_0040200	Motor impersistence	http://purl.obolibrary.org/obo/HP_0011443	Abnormality of coordination		The inability to maintain postures or positions (such as keeping eyes closed, protruding the tongue, maintaining conjugate gaze steadily in a fixed direction, or making a prolonged 'ah' sound) without repeated prompts.
http://purl.obolibrary.org/obo/HP_0040201	Simultanapraxia	http://purl.obolibrary.org/obo/HP_0040200	Motor impersistence		A subset of motor impersistence, defined as the inability to perform more than two of the simple voluntary acts simultaneously, such as closing the eyes and protruding the tongue.
http://purl.obolibrary.org/obo/HP_0040203	Abnormal CSF neopterin concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Abnormal concentration of neopterin in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0040204	Elevated CSF neopterin level	http://purl.obolibrary.org/obo/HP_0040203	Abnormal CSF neopterin concentration		Increased concentration of neopterin in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0040205	Decreased CSF neopterin level	http://purl.obolibrary.org/obo/HP_0040203	Abnormal CSF neopterin concentration		Decreased concentration of neopterin in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0040206	Abnormal circulating neopterin concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		Any deviation from the normal concentration of neopterin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0040207	Abnormal CSF pterin concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Abnormal concentration of a pterin in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0040208	Elevated CSF biopterin level	http://purl.obolibrary.org/obo/HP_0040207	Abnormal CSF pterin concentration		Concentration of biopterin in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0040209	Decreased CSF biopterin level	http://purl.obolibrary.org/obo/HP_0040207	Abnormal CSF pterin concentration		Concentration of biopterin in the cerebrospinal fluid (CSF) below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0040210	Abnormal circulating biopterin concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		A deviation from the normal concentration of biopterin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0040212	Risus sardonicus	http://purl.obolibrary.org/obo/HP_0005324	Disturbance of facial expression		Fixed sarcastic grimace and anxious expression. Caused by spasms of the masseter and other facial muscles.
http://purl.obolibrary.org/obo/HP_0040213	Hypopnea	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Hypopnea is referring to breathing that is abnormally shallow.
http://purl.obolibrary.org/obo/HP_0040214	Abnormal circulating insulin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An abnormal concentration of insulin in the body.
http://purl.obolibrary.org/obo/HP_0040216	Hypoinsulinemia	http://purl.obolibrary.org/obo/HP_0040214	Abnormal circulating insulin concentration		A decreased concentration of insulin in the blood.
http://purl.obolibrary.org/obo/HP_0040217	Elevated hemoglobin A1c	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		An increased concentration of hemoglobin A1c (HbA1c), which is the product of nonenzymatic attachment of a hexose molecule to the N-terminal amino acid of the hemoglobin molecule. This reaction is dependent on blood glucose concentration, and therefore reflects the mean glucose concentration over the previous 8 to 12 weeks. The HbA1c level provides a better indication of long-term glycemic control than one-time blood or urinary glucose measurements.
http://purl.obolibrary.org/obo/HP_0040218	Reduced total natural killer cell count	http://purl.obolibrary.org/obo/HP_0040089	Abnormal total natural killer cell count		The absolute count of natural killer cells in the blood, per microlitre, is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0040219	Absent natural killer cells	http://purl.obolibrary.org/obo/HP_0040089	Abnormal total natural killer cell count		Absence of detectable circulating NK cells, commonly characterized as CD3-CD19- and CD16+ or CD56+ lymphocytes, in the blood. Usually, less than 20 cells per microlitre is considered to be an absence.
http://purl.obolibrary.org/obo/HP_0040222	Maternal thrombophilia	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		An increased tendency towards thrombosis in the mother during a pregnancy.
http://purl.obolibrary.org/obo/HP_0040224	Abnormality of fibrinolysis	http://purl.obolibrary.org/obo/HP_0001928	Abnormality of coagulation		Clinical phenotype characterized by delayed bleeding accelerated break down of blood clot (fibrinolysis)
http://purl.obolibrary.org/obo/HP_0040225	Decrease in high molecular weight von Willebrand factor Multimers	http://purl.obolibrary.org/obo/HP_0030131	Abnormal von Willebrand factor multimer distribution		A decrease in high molecular weight von Willebrand factor multimers.
http://purl.obolibrary.org/obo/HP_0040226	Decreased level of heparin co-factor II	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		An abnormality of coagulation related to a decreased concentration of heparin co-factor II
http://purl.obolibrary.org/obo/HP_0040227	Decreased level of histidine-rich glycoprotein	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Decrease of these levels result in increased inhibition of fibrinolysis and reduced inhibition of coagulation
http://purl.obolibrary.org/obo/HP_0040228	Decreased circulating plasminogen concentration	http://purl.obolibrary.org/obo/HP_0032312	Decreased circulating globulin concentration		The concentration of plasminogen in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0040229	Decreased level of thrombomodulin	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Thrombomodulin is a cofactor in the thrombin induced activation of Protein C. In the case of deficiency there will be less Protein C and tendency to clot
http://purl.obolibrary.org/obo/HP_0040230	Decreased level of tissue plasminogen activator	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		The tPA protein catalyzes the conversion of plasiminogen to plasmin, and thus break down of clots. When there is a deficiency there will be an increase of thrombosis
http://purl.obolibrary.org/obo/HP_0040232	Delayed onset bleeding	http://purl.obolibrary.org/obo/HP_0040231	Abnormal onset of bleeding		Abnormal bleeding related to a procedure or trauma which does not start at the time of the initial insult, but after delay by at least 24 hours.
http://purl.obolibrary.org/obo/HP_0040233	Factor XIII subunit A deficiency	http://purl.obolibrary.org/obo/HP_0008357	Reduced factor XIII activity		Deficiency of factor XIII subunit A, leading to a reduced factor XIII activity. Activated Factor XIII cross-links fibrin polymers solidifying the clot.
http://purl.obolibrary.org/obo/HP_0040234	Factor XIII subunit B deficiency	http://purl.obolibrary.org/obo/HP_0008357	Reduced factor XIII activity		Deficiency of factor XIII subunit B, leading to a reduced factor XIII activity. Activated Factor XIII cross-links fibrin polymers solidifying the clot.
http://purl.obolibrary.org/obo/HP_0040235	Leukocyte inclusion bodies	http://purl.obolibrary.org/obo/HP_0008264	Neutrophil inclusion bodies		The presence of intraceullar inclusion bodies (aggregates of stainable substances, usually proteins) in leukocytes.
http://purl.obolibrary.org/obo/HP_0040236	Hyperfibrinolysis	http://purl.obolibrary.org/obo/HP_0040224	Abnormality of fibrinolysis		Increased degradation of fibrin, associated with clot instability and bleeding
http://purl.obolibrary.org/obo/HP_0040237	Impaired binding of factor VIII to VWF	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		Impaired binding of factor VIII to von Willebrand Factor. This is determined using a modified ELISA assay.
http://purl.obolibrary.org/obo/HP_0040238	Impaired neutrophil chemotaxis	http://purl.obolibrary.org/obo/HP_0005400	Reduction of neutrophil motility		An impairment of the migration of neutrophils towards chemoattractants as part of the innate immune response
http://purl.obolibrary.org/obo/HP_0040239	Increased plasma vitamin K epoxide after vitamin K supplementation	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Increased plasma vitamin K epoxide after vitamin K supplementation is present in VKCFD (vitamin K-dependent clotting factor deficiency) type 2, but not in VKCFD type 1.
http://purl.obolibrary.org/obo/HP_0040240	Increased ratio of VWF propeptide to VWF antigen	http://purl.obolibrary.org/obo/HP_0012146	Abnormality of von Willebrand factor		An increased VWF propeptide to VWF antigen indicates that deficiency of VWF is not due to impaired synthesis but due to rapid clearance. The VWF propeptide is measured by ELISA.
http://purl.obolibrary.org/obo/HP_0040241	Increased RIPA	http://purl.obolibrary.org/obo/HP_0030402	Abnormal platelet aggregation		Increased platelet agglutination in response to low-dose ristocetin
http://purl.obolibrary.org/obo/HP_0040242	Muscle hemorrhage	http://purl.obolibrary.org/obo/HP_0011029	Internal hemorrhage		Bleeding occurring within a muscle
http://purl.obolibrary.org/obo/HP_0040243	Prolonged euglobulin clot lysis time	http://purl.obolibrary.org/obo/HP_0040224	Abnormality of fibrinolysis		Abnormally increased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored.
http://purl.obolibrary.org/obo/HP_0040244	Prolonged Russell's viper venom time	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Increased time to coagulation in the Russell's viper venom assay
http://purl.obolibrary.org/obo/HP_0040245	Reduced alpha-2-antiplasmin activity	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Reduced activity of alpha-2-antiplasmin. This protein inactivates the protease plasmin that drives fibrinolysis.
http://purl.obolibrary.org/obo/HP_0040246	Reduced antithrombin antigen	http://purl.obolibrary.org/obo/HP_0010990	Abnormality of the common coagulation pathway		Reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation.
http://purl.obolibrary.org/obo/HP_0040247	Reduced euglobulin clot lysis time	http://purl.obolibrary.org/obo/HP_0040224	Abnormality of fibrinolysis		Abnormally decreased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored.
http://purl.obolibrary.org/obo/HP_0040248	Reduced plasminogen activator inhibitor 1 activity	http://purl.obolibrary.org/obo/HP_0430126	Abnormal circulating plasminogen activator inhibitor 1 activity		Reduced activity of plasminogen activator inhibitor 1. This protein down-regulates fibrinolysis in the circulation by inhibiting the two major plasminogen activators: tissue-plasminogen activator and urokinase-plasminogen activator.
http://purl.obolibrary.org/obo/HP_0040249	Reduced plasminogen activator inhibitor 1 antigen	http://purl.obolibrary.org/obo/HP_0430126	Abnormal circulating plasminogen activator inhibitor 1 activity		Reduced level of plasminogen activator inhibitor 1 antigen.
http://purl.obolibrary.org/obo/HP_0040250	Reduced prothrombin antigen	http://purl.obolibrary.org/obo/HP_0012200	Abnormality of prothrombin		Reduced prothrombin antigen as measured by ELISA assay. Prothrombin is a vitamin K-dependent coagulation factor that is proteolytically cleaved to form thrombin.
http://purl.obolibrary.org/obo/HP_0040251	Hand dimple	http://purl.obolibrary.org/obo/HP_0010781	Skin dimple		A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the hand.
http://purl.obolibrary.org/obo/HP_0040256	Aplastic/Hypoplastic nasopharyngeal adenoids	http://purl.obolibrary.org/obo/HP_3000033	Abnormal nasopharyngeal adenoid morphology		Absence or underdevelopment of the nasopharyngeal adenoids.
http://purl.obolibrary.org/obo/HP_0040257	Abnormal size of nasopharyngeal adenoids	http://purl.obolibrary.org/obo/HP_3000033	Abnormal nasopharyngeal adenoid morphology		A deviation in the size of nasopharyngeal adenoids.
http://purl.obolibrary.org/obo/HP_0040258	Hypoplastic nasopharyngeal adenoids	http://purl.obolibrary.org/obo/HP_0040260	Decreased size of nasopharyngeal adenoids		Underdevelopment of the nasopharyngeal adenoids.
http://purl.obolibrary.org/obo/HP_0040259	Aplastic nasopharyngeal adenoids	http://purl.obolibrary.org/obo/HP_0040256	Aplastic/Hypoplastic nasopharyngeal adenoids		Absence of the nasopharyngeal adenoids as a developmental defect.
http://purl.obolibrary.org/obo/HP_0040260	Decreased size of nasopharyngeal adenoids	http://purl.obolibrary.org/obo/HP_0040257	Abnormal size of nasopharyngeal adenoids		An abnormal decrease in the size of nasopharyngeal adenoids.
http://purl.obolibrary.org/obo/HP_0040261	Increased size of nasopharyngeal adenoids	http://purl.obolibrary.org/obo/HP_0040257	Abnormal size of nasopharyngeal adenoids		An abnormal increase in the size of nasopharyngeal adenoids.
http://purl.obolibrary.org/obo/HP_0040262	Glue ear	http://purl.obolibrary.org/obo/HP_0000388	Otitis media		Middle ear is filled with glue-like fluid instead of air.
http://purl.obolibrary.org/obo/HP_0040264	Jaw pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the jaw.
http://purl.obolibrary.org/obo/HP_0040265	Upper limb muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0003712	Skeletal muscle hypertrophy		Abnormal increase in muscle size and mass of one or both arms not due to training.
http://purl.obolibrary.org/obo/HP_0040270	Impaired glucose tolerance	http://purl.obolibrary.org/obo/HP_0001952	Glucose intolerance		An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose.
http://purl.obolibrary.org/obo/HP_0040272	Hyperintensity of MRI T2 signal of the spinal cord	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		A region of high intensity (brightness) observed upon magnetic resonance imaging (MRI) scans of the spinal cord.
http://purl.obolibrary.org/obo/HP_0040273	Adenocarcinoma of the intestines	http://purl.obolibrary.org/obo/HP_0002672	Gastrointestinal carcinoma		A malignant epithelial tumor with a glandular organization that originates in the intestines.
http://purl.obolibrary.org/obo/HP_0040275	Adenocarcinoma of the large intestine	http://purl.obolibrary.org/obo/HP_0040273	Adenocarcinoma of the intestines		A malignant epithelial tumor with a glandular organization that originates in the large intestine.
http://purl.obolibrary.org/obo/HP_0040279	Frequency	http://purl.obolibrary.org/obo/HP_0000001	All		Class to represent frequency of phenotypic abnormalities within a patient cohort.
http://purl.obolibrary.org/obo/HP_0040280	Obligate	http://purl.obolibrary.org/obo/HP_0040279	Frequency		Always present, i.e. in 100% of the cases.
http://purl.obolibrary.org/obo/HP_0040281	Very frequent	http://purl.obolibrary.org/obo/HP_0040279	Frequency		Present in 80% to 99% of the cases.
http://purl.obolibrary.org/obo/HP_0040282	Frequent	http://purl.obolibrary.org/obo/HP_0040279	Frequency		Present in 30% to 79% of the cases.
http://purl.obolibrary.org/obo/HP_0040283	Occasional	http://purl.obolibrary.org/obo/HP_0040279	Frequency		Present in 5% to 29% of the cases.
http://purl.obolibrary.org/obo/HP_0040284	Very rare	http://purl.obolibrary.org/obo/HP_0040279	Frequency		Present in 1% to 4% of the cases.
http://purl.obolibrary.org/obo/HP_0040285	Excluded	http://purl.obolibrary.org/obo/HP_0040279	Frequency		Present in 0% of the cases.
http://purl.obolibrary.org/obo/HP_0045006	Aplasia of lymphatic vessels	http://purl.obolibrary.org/obo/HP_0100766	Abnormal lymphatic vessel morphology		Aplasia (absence) of the lymphatic vessels.
http://purl.obolibrary.org/obo/HP_0045011	Decreased urine bicarbonate concentration	http://purl.obolibrary.org/obo/HP_0011279	Abnormality of urine bicarbonate level		Abnormally decreased concentration of hydrogencarbonate in the urine.
http://purl.obolibrary.org/obo/HP_0045025	Narrow palpebral fissure	http://purl.obolibrary.org/obo/HP_0200007	Abnormal size of the palpebral fissures		Reduction in the vertical distance between the upper and lower eyelids.
http://purl.obolibrary.org/obo/HP_0045026	Abnormal mediastinum morphology	http://purl.obolibrary.org/obo/HP_0045027	Abnormality of the thoracic cavity		Any structural anomaly of the central compartment of the thoracic cavity.
http://purl.obolibrary.org/obo/HP_0045028	Microlissencephaly	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		Severe microcephaly and lissencephaly with granular surfaces with immature cortical plate, reduced in thickness, with focal polymicrogyria and immature small neurons with rare processes, intermingled with a considerable number of glial elements.
http://purl.obolibrary.org/obo/HP_0045029	Eosinophilic fasciitis	http://purl.obolibrary.org/obo/HP_0100537	Fasciitis		Inflammation and thickening (localized fibrosis) of the fascia, the tissue under the skin and over the muscle, typically associated with a build up of eosinophils in the muscles and tissues.
http://purl.obolibrary.org/obo/HP_0045034	Elevated urinary 3-aminoisobutyric acid	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		An increased amount of 3-aminoisobutyric acid in the urine.
http://purl.obolibrary.org/obo/HP_0045038	Gastric lymphoma	http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach		Lymphoma that originates in the stomach itself.
http://purl.obolibrary.org/obo/HP_0045040	Abnormal circulating lactate dehydrogenase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate.
http://purl.obolibrary.org/obo/HP_0045041	Reduced circulating lactate dehydrogenase concentration	http://purl.obolibrary.org/obo/HP_0045040	Abnormal circulating lactate dehydrogenase concentration		Concentration of lactate dehydrogenase in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0045042	Decreased circulating complement C4 concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		Concentration of the complement component C4 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0045043	Decreased circulating complement C4a concentration	http://purl.obolibrary.org/obo/HP_0045042	Decreased circulating complement C4 concentration		Concentration of the complement component C4a in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0045044	Decreased circulating complement C4b concentration	http://purl.obolibrary.org/obo/HP_0045042	Decreased circulating complement C4 concentration		Concentration of the complement component C4b in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0045045	Elevated circulating acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0012071	Abnormal circulating acylcarnitine concentration		Concentration of acylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0045046	Decreased circulating insulin-like growth factor-binding protein acid labile subunit concentration	http://purl.obolibrary.org/obo/HP_0031034	Abnormal circulating insulin-like growth factor-binding protein acid labile subunit concentration		The concentration of insulin-like growth factor-binding protein acid labile subunit in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0045047	HbS hemoglobin	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Presence of an abnormal type of hemoglobin characterized by the substitution of a glutamic acid residue at position 7 following the initial methionine residue by a valine (the mutation causative of sickle cell disease). The mutation promotes the polymerization of the HbS under conditions of low oxygen concentration. HbS can be identified by multiple methodologies including hemoglobin electrophoresis and high-performance liquid chromatography.
http://purl.obolibrary.org/obo/HP_0045048	Increased HbA2 hemoglobin	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia.
http://purl.obolibrary.org/obo/HP_0045049	Abnormal DLCO	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		An abnormal amount of oxygen passes into the blood from the lungs and/or an abnormal amount of carbon dioxide passes from the blood into the lungs.
http://purl.obolibrary.org/obo/HP_0045050	Increased DLCO	http://purl.obolibrary.org/obo/HP_0045049	Abnormal DLCO		Increased ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test.
http://purl.obolibrary.org/obo/HP_0045051	Decreased DLCO	http://purl.obolibrary.org/obo/HP_0045049	Abnormal DLCO		Reduced ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test.
http://purl.obolibrary.org/obo/HP_0045052	Abnormality of the brachial nerve plexus	http://purl.obolibrary.org/obo/HP_0410010	Abnormality of somatic nerve plexus		Any abnormality of the brachial nerve plexus.
http://purl.obolibrary.org/obo/HP_0045053	Abnormality of the lumbosacral nerve plexus	http://purl.obolibrary.org/obo/HP_0410010	Abnormality of somatic nerve plexus		Any abnormality of the lumbosacral nerve plexus.
http://purl.obolibrary.org/obo/HP_0045055	Tiger tail banding	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		An abnormal appearance of hair under polarizing microscopy (using crossed polarizers), whereby hair shafts show striking alternating bright and dark bands, often referred to as tiger tail banding.
http://purl.obolibrary.org/obo/HP_0045057	Decreased circulating alpha-fetoprotein concentration	http://purl.obolibrary.org/obo/HP_0045056	Abnormal circulating alpha-fetoprotein concentration		The concentration of alpha-fetoprotein in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0045059	Hyperkeratotic papule	http://purl.obolibrary.org/obo/HP_0200034	Papule		A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point that is composed of localized hyperkeratosis (the latter may be demonstrated histopathologically).
http://purl.obolibrary.org/obo/HP_0045063	Increased PIVKA-II	http://purl.obolibrary.org/obo/HP_0012200	Abnormality of prothrombin		Des-gamma carboxyprothrombin (DCP) or pro-thrombin induced by vitamin K absence-II (PIVKA-II) is an abnormal prothrombin protein that is increased in the serum of patients with HCC. Generation of DCP is thought to be a result of an acquired defect in the post- translational carboxylation of the prothrombin precursor in malignant cells.
http://purl.obolibrary.org/obo/HP_0045079	Distal femoral metaphyseal irregularity	http://purl.obolibrary.org/obo/HP_0030291	Lower-limb metaphyseal irregularity		Irregularity of the normally smooth surface of the distal metaphysis of the femur.
http://purl.obolibrary.org/obo/HP_0400000	Tall chin	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		Increased vertical distance from the vermillion border of the lower lip to the inferior-most point of the chin.
http://purl.obolibrary.org/obo/HP_0400001	Chin with vertical crease	http://purl.obolibrary.org/obo/HP_0000306	Abnormality of the chin		Vertical crease fold situated below the vermilion border of the lower lip and above the fatty pad of the chin with the face at rest.
http://purl.obolibrary.org/obo/HP_0400002	Extra concha fold	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Folds or ridges within the concha that are distinct from the crus helix.
http://purl.obolibrary.org/obo/HP_0400003	Focal absence of the external ear	http://purl.obolibrary.org/obo/HP_0008772	Aplasia/Hypoplasia of the external ear		Absence of a localized portion of the ear that cannot be described by a more precise term (e.g., absent ear lobe).
http://purl.obolibrary.org/obo/HP_0400004	Long ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Median longitudinal ear length greater than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear.
http://purl.obolibrary.org/obo/HP_0400005	Short ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		Median longitudinal ear length less than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear.
http://purl.obolibrary.org/obo/HP_0400007	Polymenorrhea	http://purl.obolibrary.org/obo/HP_0000140	Abnormality of the menstrual cycle		Frequent menses; menstrual cycles lasting less than 21 days.
http://purl.obolibrary.org/obo/HP_0400008	Menometrorrhagia	http://purl.obolibrary.org/obo/HP_0000140	Abnormality of the menstrual cycle		Prolonged/excessive menses and bleeding at irregular intervals.
http://purl.obolibrary.org/obo/HP_0410000	Abnormal vomer morphology	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		An abnormality of the vomer.
http://purl.obolibrary.org/obo/HP_0410006	Abnormality of ophthalmic artery	http://purl.obolibrary.org/obo/HP_3000062	Abnormal internal carotid artery morphology		Abnormality of the first branch of the internal carotid artery.
http://purl.obolibrary.org/obo/HP_0410009	Abnormality of the somatic nervous system	http://purl.obolibrary.org/obo/HP_0410008	Abnormality of the peripheral nervous system		Any abnormality of the part of the peripheral nervous system associated with sensation and skeletal muscle voluntary control of body movements.
http://purl.obolibrary.org/obo/HP_0410010	Abnormality of somatic nerve plexus	http://purl.obolibrary.org/obo/HP_0410009	Abnormality of the somatic nervous system		Any abnormality of the somatic nerve plexus.
http://purl.obolibrary.org/obo/HP_0410011	Abnormality of masticatory muscle	http://purl.obolibrary.org/obo/HP_0045037	Abnormality of jaw muscles		Any abnormality of the masticatory muscle.
http://purl.obolibrary.org/obo/HP_0410012	Abnormal mouth floor morphology	http://purl.obolibrary.org/obo/HP_0000163	Abnormal oral cavity morphology		Any abnormality of the mouth floor.
http://purl.obolibrary.org/obo/HP_0410013	Abnormality of the submandibular region	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		Any abnormality of the submandibular region, the region between the mandible and the hyoid bone contains the submandibular and sublingual glands, suprahyoid muscles, submandibular ganglion, and lingual artery.
http://purl.obolibrary.org/obo/HP_0410014	Abnormal ganglion morphology	http://purl.obolibrary.org/obo/HP_0012639	Abnormal nervous system morphology		An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0410015	Abnormal peripheral nervous system ganglion morphology	http://purl.obolibrary.org/obo/HP_0410014	Abnormal ganglion morphology		An abnormality of nerve cell cluster or a group of nerve cell bodies located in the peripheral autonomic nervous system.
http://purl.obolibrary.org/obo/HP_0410016	Abnormal cranial ganglion morphology	http://purl.obolibrary.org/obo/HP_0410014	Abnormal ganglion morphology		An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system of the cranium.
http://purl.obolibrary.org/obo/HP_0430000	Abnormal frontal bone morphology	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		An abnormality of the frontal bone.
http://purl.obolibrary.org/obo/HP_0430002	Abnormal lacrimal bone morphology	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		An abnormality of the lacrimal bone.
http://purl.obolibrary.org/obo/HP_0430003	Abnormal palatine bone morphology	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		An abnormality of the palatine bone.
http://purl.obolibrary.org/obo/HP_0430005	Abnormal ethmoid bone morphology	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		An abnormality of the ethmoid bone
http://purl.obolibrary.org/obo/HP_0430006	Ectopic cilia of eyelid	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		An eyelash that emerges from the underside (conjunctiva) of the upper or lower eyelid.
http://purl.obolibrary.org/obo/HP_0430007	Symblepharon	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		A partial or complete adhesion of the palpebral conjunctiva of the eyelid to the bulbar conjunctiva of the eyeball.
http://purl.obolibrary.org/obo/HP_0430008	Accessory eyelid	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		The presence of more than the normal number of eyelids.
http://purl.obolibrary.org/obo/HP_0430010	Microblepharia	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Abnormal shortness of the vertical dimensions of the eyelids.
http://purl.obolibrary.org/obo/HP_0430011	Defect of palpebral conjunctiva	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		An abnormality of the palpebral conjunctiva.
http://purl.obolibrary.org/obo/HP_0430012	Incomplete ossification of palatine bone	http://purl.obolibrary.org/obo/HP_0430003	Abnormal palatine bone morphology		Failure to complete ossification (maturation and calcification) of the palatine bone.
http://purl.obolibrary.org/obo/HP_0430013	Absent palatine bone ossification	http://purl.obolibrary.org/obo/HP_0430003	Abnormal palatine bone morphology		Lack of formation of the palatine bone.
http://purl.obolibrary.org/obo/HP_0430014	Abnormality of musculature of soft palate	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		An abnormality of one or more of the five muscles of the soft palate.
http://purl.obolibrary.org/obo/HP_0430015	Abnormal morphology of musculature of pharynx	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		An abnormality of any of the muscles of the pharynx.
http://purl.obolibrary.org/obo/HP_0430016	Abnormality of tensor veli palatini muscle	http://purl.obolibrary.org/obo/HP_0430014	Abnormality of musculature of soft palate		An abnormality of the tensor veli palatini muscle
http://purl.obolibrary.org/obo/HP_0430017	Abnormality of uvular muscle	http://purl.obolibrary.org/obo/HP_0430014	Abnormality of musculature of soft palate		An abnormality of the uvular muscle
http://purl.obolibrary.org/obo/HP_0430018	Abnormality of nasal musculature	http://purl.obolibrary.org/obo/HP_0000301	Abnormality of facial musculature		An abnormality of the muscles of the structure of the nose.
http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression	http://purl.obolibrary.org/obo/HP_0000301	Abnormality of facial musculature		An abnormality of any of the muscles of facial expression, which are innervated by the seventh (VII) cranial nerve and control facial expression.
http://purl.obolibrary.org/obo/HP_0430020	Abnormality of levator labii superioris alaeque nasi muscle	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of the levator labii superioris alaeque nasi muscle.
http://purl.obolibrary.org/obo/HP_0430021	Abnormal common carotid artery morphology	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		An abnormality of the common carotid arteries, which provide the arterial supply to the head and neck and give rise to the internal carotid artery and the external carotid artery.
http://purl.obolibrary.org/obo/HP_0430022	Abnormality of the sphenoid sinus	http://purl.obolibrary.org/obo/HP_0000245	Abnormal paranasal sinus morphology		An abnormality of the sphenoid sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The sphenoid sinus is located within the sphenoid bone.
http://purl.obolibrary.org/obo/HP_0430023	Abnormality of the maxillary sinus	http://purl.obolibrary.org/obo/HP_0000245	Abnormal paranasal sinus morphology		An abnormality of the maxillary sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The maxillary sinus is located within the skeleton of the midface, lateral to the nasal cavity.
http://purl.obolibrary.org/obo/HP_0430024	Abnormality of external jugular vein	http://purl.obolibrary.org/obo/HP_3000042	Abnormal jugular vein morphology		An abnormality of an external jugular vein of the neck.
http://purl.obolibrary.org/obo/HP_0430025	Bilateral facial palsy	http://purl.obolibrary.org/obo/HP_0010628	Facial palsy		Two-sided or bilateral weakness of the muscles of facial expression and eye closure.
http://purl.obolibrary.org/obo/HP_0430028	Hyperplasia of the maxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		Abnormally increased dimension of the maxilla, especially relative to the mandible, resulting in a malocclusion or malalignment between the upper and lower teeth or in anterior positioning of the nasal base, increased convexity of the face, increased nasolabial angle, or increased width (transverse dimension of the maxilla.
http://purl.obolibrary.org/obo/HP_0430029	Hyperplasia of the premaxilla	http://purl.obolibrary.org/obo/HP_0010758	Abnormality of the premaxilla		An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively large in size compared to the other parts of the maxilla or other facial structures.
http://purl.obolibrary.org/obo/HP_3000005	Abnormality of masseter muscle	http://purl.obolibrary.org/obo/HP_0410011	Abnormality of masticatory muscle		An abnormality of a masseter muscle.
http://purl.obolibrary.org/obo/HP_3000006	Abnormality of medial pterygoid muscle	http://purl.obolibrary.org/obo/HP_0410011	Abnormality of masticatory muscle		An abnormality of a medial pterygoid muscle.
http://purl.obolibrary.org/obo/HP_3000007	Abnormality of mentalis muscle	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a mentalis muscle.
http://purl.obolibrary.org/obo/HP_3000008	Abnormality of mylohyoid muscle	http://purl.obolibrary.org/obo/HP_0410013	Abnormality of the submandibular region		An abnormality of a mylohyoid muscle.
http://purl.obolibrary.org/obo/HP_3000009	Abnormality of nasalis muscle	http://purl.obolibrary.org/obo/HP_0430018	Abnormality of nasal musculature		An abnormality of a nasalis muscle.
http://purl.obolibrary.org/obo/HP_3000010	Abnormality of orbicularis oris muscle	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of an orbicularis oris muscle.
http://purl.obolibrary.org/obo/HP_3000011	Abnormality of palatoglossus muscle	http://purl.obolibrary.org/obo/HP_0430014	Abnormality of musculature of soft palate		An abnormality of a palatoglossus muscle.
http://purl.obolibrary.org/obo/HP_3000012	Abnormality of palatopharyngeus muscle	http://purl.obolibrary.org/obo/HP_0430015	Abnormal morphology of musculature of pharynx		An abnormality of a palatopharyngeus muscle.
http://purl.obolibrary.org/obo/HP_3000013	Abnormal platysma muscle morphology	http://purl.obolibrary.org/obo/HP_0011006	Abnormal morphology of the musculature of the neck		An abnormality of the platysma muscle.
http://purl.obolibrary.org/obo/HP_3000014	Abnormality of procerus muscle	http://purl.obolibrary.org/obo/HP_0430018	Abnormality of nasal musculature		An abnormality of a procerus.
http://purl.obolibrary.org/obo/HP_3000015	Abnormality of risorius muscle	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a risorius muscle.
http://purl.obolibrary.org/obo/HP_3000016	Abnormality of styloglossus muscle	http://purl.obolibrary.org/obo/HP_0040174	Abnormality of extrinsic muscle of tongue		An abnormality of the styloglossus muscle.
http://purl.obolibrary.org/obo/HP_3000017	Abnormality of temporalis muscle	http://purl.obolibrary.org/obo/HP_0410011	Abnormality of masticatory muscle		An abnormality of a temporalis muscle.
http://purl.obolibrary.org/obo/HP_3000018	Abnormality of zygomaticus major muscle	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a zygomaticus major muscle.
http://purl.obolibrary.org/obo/HP_3000019	Abnormal buccal mucosa morphology	http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology		An abnormality of a buccal mucosa.
http://purl.obolibrary.org/obo/HP_3000020	Abnormality of zygomaticus minor muscle	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a zygomaticus minor muscle.
http://purl.obolibrary.org/obo/HP_3000021	Abnormal buccal fat pad morphology	http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology		An abnormality of a buccal fat pad.
http://purl.obolibrary.org/obo/HP_3000023	Abnormality of angular artery	http://purl.obolibrary.org/obo/HP_3000024	Abnormal facial artery morphology		An abnormality of the angular artery, the terminal branch of the facial artery.
http://purl.obolibrary.org/obo/HP_3000024	Abnormal facial artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any structural abnormality of a facial artery, one of the branches of the external carotid artery.
http://purl.obolibrary.org/obo/HP_3000025	Abnormality of ciliary ganglion	http://purl.obolibrary.org/obo/HP_0410016	Abnormal cranial ganglion morphology		An abnormality of a ciliary ganglion.
http://purl.obolibrary.org/obo/HP_3000027	Abnormality of buccinator muscle	http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology		An abnormality of a buccinator muscle.
http://purl.obolibrary.org/obo/HP_3000028	Abnormality of depressor anguli oris muscle	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a depressor anguli oris muscle.
http://purl.obolibrary.org/obo/HP_3000029	Abnormality of depressor labii inferioris	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a depressor labii inferioris.
http://purl.obolibrary.org/obo/HP_3000031	Abnormality of anterior ethmoidal artery	http://purl.obolibrary.org/obo/HP_0410006	Abnormality of ophthalmic artery		An abnormality of an anterior ethmoidal artery.
http://purl.obolibrary.org/obo/HP_3000032	Abnormality of central retinal artery	http://purl.obolibrary.org/obo/HP_0410006	Abnormality of ophthalmic artery		An abnormality of a central retinal artery.
http://purl.obolibrary.org/obo/HP_3000033	Abnormal nasopharyngeal adenoid morphology	http://purl.obolibrary.org/obo/HP_0100765	Abnormality of the tonsils		Any abnormality of nasopharyngeal adenoids.
http://purl.obolibrary.org/obo/HP_3000035	Abnormality of cervical plexus	http://purl.obolibrary.org/obo/HP_0410010	Abnormality of somatic nerve plexus		Abnormality of the plexus of the ventral rami of the first four cervical spinal nerves which are located from C1 to C4 cervical segment in the neck.
http://purl.obolibrary.org/obo/HP_3000037	Abnormal neck blood vessel morphology	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		An abnormality of a blood vessel of the neck, including branches of the arterial and venous systems of the neck.
http://purl.obolibrary.org/obo/HP_3000038	Abnormal cricoid cartilage morphology	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Any structural abnormality of a cricoid cartilage, that is, of the ring-shaped cartilage of the larynx.
http://purl.obolibrary.org/obo/HP_3000039	Abnormality of dorsal nasal artery	http://purl.obolibrary.org/obo/HP_0410006	Abnormality of ophthalmic artery		An abnormality of a dorsal nasal artery.
http://purl.obolibrary.org/obo/HP_3000041	Abnormal external carotid artery morphology	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		A structural abnormality of an external carotid artery.
http://purl.obolibrary.org/obo/HP_3000042	Abnormal jugular vein morphology	http://purl.obolibrary.org/obo/HP_3000037	Abnormal neck blood vessel morphology		Any structural abnormality of a jugular vein.
http://purl.obolibrary.org/obo/HP_3000043	Abnormal facial vein morphology	http://purl.obolibrary.org/obo/HP_3000037	Abnormal neck blood vessel morphology		An abnormality of a facial vein.
http://purl.obolibrary.org/obo/HP_3000044	Abnormality of frontal process of maxilla	http://purl.obolibrary.org/obo/HP_0000326	Abnormal maxilla morphology		An abnormality of a frontal process of the maxilla bone.
http://purl.obolibrary.org/obo/HP_3000045	Abnormality of genioglossus muscle	http://purl.obolibrary.org/obo/HP_0040174	Abnormality of extrinsic muscle of tongue		An abnormality of a genioglossus muscle.
http://purl.obolibrary.org/obo/HP_3000046	Abnormal geniohyoid muscle morphology	http://purl.obolibrary.org/obo/HP_0011006	Abnormal morphology of the musculature of the neck		An abnormality of a geniohyoid muscle.
http://purl.obolibrary.org/obo/HP_3000047	Abnormal glossopharyngeal nerve morphology	http://purl.obolibrary.org/obo/HP_0045010	Abnormal peripheral nerve morphology by anatomical site		Any structural anomaly of the glossopharyngeal nerve, the ninth paired cranial nerve (CN IX).
http://purl.obolibrary.org/obo/HP_3000048	Abnormal great auricular nerve morphology	http://purl.obolibrary.org/obo/HP_0045010	Abnormal peripheral nerve morphology by anatomical site		Any structural anomaly of a great auricular nerve.
http://purl.obolibrary.org/obo/HP_3000049	Abnormal greater palatine artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		An abnormality of a greater palatine artery.
http://purl.obolibrary.org/obo/HP_3000051	Abnormal hyoglossus muscle morphology	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		An abnormality of a hyoglossus muscle.
http://purl.obolibrary.org/obo/HP_3000052	Abnormal hyoid bone morphology	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Any structural abnormality of the hyoid bone (hyoid), a small U-shaped (horseshoe-shaped) solitary bone, situated in the midline of the neck anteriorly at the base of the mandible and posteriorly at the fourth cervical vertebra.
http://purl.obolibrary.org/obo/HP_3000053	Abnormal hypopharynx morphology	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		A structural anomaly of the hypopharyx, which is the most inferior portion of the pharynx. The hypopharynx continues from the oropharynx at the pharyngoepiglottic fold superiorly and extends inferiorly to the level of the inferior aspect of the cricoid cartilage, which marks the beginning of the cervical esophagus.
http://purl.obolibrary.org/obo/HP_3000054	Abnormal inferior alveolar artery morphology	http://purl.obolibrary.org/obo/HP_0031816	Abnormal oral morphology		An abnormality of an inferior alveolar artery.
http://purl.obolibrary.org/obo/HP_3000055	Abnormality of inferior alveolar nerve	http://purl.obolibrary.org/obo/HP_0045010	Abnormal peripheral nerve morphology by anatomical site		An abnormality of an inferior alveolar nerve.
http://purl.obolibrary.org/obo/HP_3000056	Abnormality of artery of lower lip	http://purl.obolibrary.org/obo/HP_3000024	Abnormal facial artery morphology		An abnormality of an artery of lower lip.
http://purl.obolibrary.org/obo/HP_3000057	Abnormality of inferior oblique extraocular muscle	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		An abnormality of an inferior oblique extraocular muscle.
http://purl.obolibrary.org/obo/HP_3000058	Abnormality of inferior rectus extraocular muscle	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		An abnormality of an inferior rectus extraocular muscle.
http://purl.obolibrary.org/obo/HP_3000059	Abnormal inferior thyroid vein morphology	http://purl.obolibrary.org/obo/HP_0002624	Abnormal venous morphology		An abnormality of an inferior thyroid vein.
http://purl.obolibrary.org/obo/HP_3000060	Abnormal infraorbital artery morphology	http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology		An abnormality of an infraorbital artery.
http://purl.obolibrary.org/obo/HP_3000061	Abnormality of infra-orbital nerve	http://purl.obolibrary.org/obo/HP_0010824	Abnormal fifth cranial nerve morphology		A structural abnormality of an infra-orbital nerve. The infraorbital nerve arises from the maxillary branch of the trigeminal nerve and normally traverses the orbital floor in the infraorbital canal.
http://purl.obolibrary.org/obo/HP_3000063	Abnormality of internal jugular vein	http://purl.obolibrary.org/obo/HP_3000042	Abnormal jugular vein morphology		An abnormality of an internal jugular vein.
http://purl.obolibrary.org/obo/HP_3000064	Abnormality of intrinsic muscle of tongue	http://purl.obolibrary.org/obo/HP_0040173	Abnormality of the tongue muscle		An abnormality of an intrinsic muscle of tongue.
http://purl.obolibrary.org/obo/HP_3000065	Abnormal lacrimal artery morphology	http://purl.obolibrary.org/obo/HP_3000036	Abnormal head blood vessel morphology		An abnormality of a lacrimal artery.
http://purl.obolibrary.org/obo/HP_3000066	Abnormal lacrimal sac morphology	http://purl.obolibrary.org/obo/HP_0000614	Abnormal nasolacrimal system morphology		An abnormality of a lacrimal sac.
http://purl.obolibrary.org/obo/HP_3000067	Abnormal lateral cricoarytenoid muscle morphology	http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology		Any structural abnormality of a lateral crico-arytenoid muscle, which extends from the lateral cricoid cartilage to the muscular process of the arytenoid cartilage, and can adduct the vocal cords, which closes the rima glottidis and thereby protects the airway.
http://purl.obolibrary.org/obo/HP_3000069	Abnormality of lateral rectus extra-ocular muscle	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		An abnormality of a lateral rectus extra-ocular muscle.
http://purl.obolibrary.org/obo/HP_3000070	Abnormality of levator anguli oris	http://purl.obolibrary.org/obo/HP_0430019	Abnormality of muscle of facial expression		An abnormality of a levator anguli oris.
http://purl.obolibrary.org/obo/HP_3000072	Abnormal levator palpebrae superioris morphology	http://purl.obolibrary.org/obo/HP_0008049	Abnormality of the extraocular muscles		An abnormality of a levator palpebrae superioris.
http://purl.obolibrary.org/obo/HP_3000073	Abnormality of levator veli palatini muscle	http://purl.obolibrary.org/obo/HP_0430014	Abnormality of musculature of soft palate		An abnormality of a levator veli palatini.
http://purl.obolibrary.org/obo/HP_3000074	Abnormal lingual artery morphology	http://purl.obolibrary.org/obo/HP_3000036	Abnormal head blood vessel morphology		Any structural abnormality of a lingual artery.
http://purl.obolibrary.org/obo/HP_3000076	Abnormality of lingual tonsil	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		An abnormality of a lingual tonsil.
http://purl.obolibrary.org/obo/HP_3000078	Abnormal mandible coronoid process morphology	http://purl.obolibrary.org/obo/HP_0031816	Abnormal oral morphology		An abnormality of a mandible coronoid process.
http://purl.obolibrary.org/obo/HsapDv_0000001	life cycle	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Temporal interval that defines human life from the prenatal stage until late adulthood.
http://purl.obolibrary.org/obo/HsapDv_0000045	prenatal stage	http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage		Prenatal stage that starts with fertilization and ends at birth.
http://purl.obolibrary.org/obo/MPATH_0	pathological entity	http://purl.obolibrary.org/obo/MPATH_1000	pathological phenotype observation		Pathological structure or process
http://purl.obolibrary.org/obo/MPATH_1	cell and tissue damage	http://purl.obolibrary.org/obo/MPATH_603	pathological anatomical entity		The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors.
http://purl.obolibrary.org/obo/MPATH_105	circulatory disorder	http://purl.obolibrary.org/obo/MPATH_603	pathological anatomical entity		Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body.
http://purl.obolibrary.org/obo/MPATH_126	growth and differentiation defect	http://purl.obolibrary.org/obo/MPATH_603	pathological anatomical entity		Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs.
http://purl.obolibrary.org/obo/MPATH_14	process of degenerative change	http://purl.obolibrary.org/obo/MPATH_597	cell and tissue damage process		A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell.
http://purl.obolibrary.org/obo/MPATH_149	squamous hyperplasia	http://purl.obolibrary.org/obo/MPATH_602	hyperplastic tissue		Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia).
http://purl.obolibrary.org/obo/MPATH_154	hyperkeratosis	http://purl.obolibrary.org/obo/MPATH_149	squamous hyperplasia		Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis.
http://purl.obolibrary.org/obo/MPATH_175	healing and repair process	http://purl.obolibrary.org/obo/MPATH_596	pathological process		The process, normal or abnormal, of damage repair or wound closure.
http://purl.obolibrary.org/obo/MPATH_176	connective tissue replacement	http://purl.obolibrary.org/obo/MPATH_175	healing and repair process		Replacement of connective tissue by fibro-fatty deposits and scar tissue.
http://purl.obolibrary.org/obo/MPATH_188	immunopathological process	http://purl.obolibrary.org/obo/MPATH_596	pathological process		Inappropriate or aberrant activation or suppression of the immune or inflammatory response.
http://purl.obolibrary.org/obo/MPATH_194	immune mediated disease	http://purl.obolibrary.org/obo/MPATH_188	immunopathological process		Tissue response to inappropriate immune/inflammatory process.
http://purl.obolibrary.org/obo/MPATH_196	dermatitis	http://purl.obolibrary.org/obo/MPATH_212	inflammation		Inflammation of the skin.
http://purl.obolibrary.org/obo/MPATH_212	inflammation	http://purl.obolibrary.org/obo/MPATH_194	immune mediated disease		A tissue reaction to an internal or external injury.
http://purl.obolibrary.org/obo/MPATH_218	neoplasm	http://purl.obolibrary.org/obo/MPATH_603	pathological anatomical entity		A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant.
http://purl.obolibrary.org/obo/MPATH_25	tissue specific degenerative process	http://purl.obolibrary.org/obo/MPATH_14	process of degenerative change		Degenerative process characteristic of a particular tissue.
http://purl.obolibrary.org/obo/MPATH_254	complex tumor	http://purl.obolibrary.org/obo/MPATH_218	neoplasm		Tumors showing multiple histological componants/differentiation.
http://purl.obolibrary.org/obo/MPATH_267	glandular tumor	http://purl.obolibrary.org/obo/MPATH_218	neoplasm		Neoplasms derived from glandular epithelial cells.
http://purl.obolibrary.org/obo/MPATH_270	adenoma	http://purl.obolibrary.org/obo/MPATH_556	potentially cancerous lesions		A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.
http://purl.obolibrary.org/obo/MPATH_309	gonadal tumor	http://purl.obolibrary.org/obo/MPATH_218	neoplasm		Germ cell and non-germ cell tumors of the testis and ovary.
http://purl.obolibrary.org/obo/MPATH_310	germ cell tumor	http://purl.obolibrary.org/obo/MPATH_309	gonadal tumor		Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells.
http://purl.obolibrary.org/obo/MPATH_322	teratoma	http://purl.obolibrary.org/obo/MPATH_310	germ cell tumor		Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1).
http://purl.obolibrary.org/obo/MPATH_33	intracellular and extracellular accumulation	http://purl.obolibrary.org/obo/MPATH_1	cell and tissue damage		Accumulation of substances within, on the surface of or between cells.
http://purl.obolibrary.org/obo/MPATH_335	hematopoietic/lymphoid malignancies/disorder	http://purl.obolibrary.org/obo/MPATH_218	neoplasm		Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages.
http://purl.obolibrary.org/obo/MPATH_342	myeloid leukaemia	http://purl.obolibrary.org/obo/MPATH_496	Non-Lymphoid leukaemias		Leukaemias of the myeloid lineage.
http://purl.obolibrary.org/obo/MPATH_379	odontogenic tumor	http://purl.obolibrary.org/obo/MPATH_218	neoplasm		Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) .
http://purl.obolibrary.org/obo/MPATH_404	soft tissue tumor	http://purl.obolibrary.org/obo/MPATH_218	neoplasm		Neoplasms of the soft and connective tissues.
http://purl.obolibrary.org/obo/MPATH_474	ectasia	http://purl.obolibrary.org/obo/MPATH_66	dilatation		Dilation of a tubular structure.
http://purl.obolibrary.org/obo/MPATH_496	Non-Lymphoid leukaemias	http://purl.obolibrary.org/obo/MPATH_515	non-Lymphoid neoplasias		Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition.
http://purl.obolibrary.org/obo/MPATH_515	non-Lymphoid neoplasias	http://purl.obolibrary.org/obo/MPATH_335	hematopoietic/lymphoid malignancies/disorder		Hematological neoplasias of non-lymphoid origin.
http://purl.obolibrary.org/obo/MPATH_55	developmental and structural abnormality	http://purl.obolibrary.org/obo/MPATH_603	pathological anatomical entity		Developmental and structural abnormalities occurring during embryonic development or during adult life.
http://purl.obolibrary.org/obo/MPATH_555	mineralisation	http://purl.obolibrary.org/obo/MPATH_33	intracellular and extracellular accumulation		Deposition of any homogeneous inorganic material.
http://purl.obolibrary.org/obo/MPATH_556	potentially cancerous lesions	http://purl.obolibrary.org/obo/MPATH_218	neoplasm		Lesions which in some cases have the potential to become progressively growing malignant tumors.
http://purl.obolibrary.org/obo/MPATH_56	developmental or adult structural  defect	http://purl.obolibrary.org/obo/MPATH_55	developmental and structural abnormality		Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult.
http://purl.obolibrary.org/obo/MPATH_596	pathological process	http://purl.obolibrary.org/obo/MPATH_0	pathological entity		The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.
http://purl.obolibrary.org/obo/MPATH_597	cell and tissue damage process	http://purl.obolibrary.org/obo/MPATH_596	pathological process		Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology.
http://purl.obolibrary.org/obo/MPATH_599	developmental process abnormalities	http://purl.obolibrary.org/obo/MPATH_596	pathological process		developmental process abnormalities
http://purl.obolibrary.org/obo/MPATH_602	hyperplastic tissue	http://purl.obolibrary.org/obo/MPATH_126	growth and differentiation defect		An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation.
http://purl.obolibrary.org/obo/MPATH_603	pathological anatomical entity	http://purl.obolibrary.org/obo/MPATH_0	pathological entity		Anatomically located instance of pathological response or entity.
http://purl.obolibrary.org/obo/MPATH_607	healing and repair structure	http://purl.obolibrary.org/obo/MPATH_603	pathological anatomical entity		Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage.
http://purl.obolibrary.org/obo/MPATH_64	developmental dysplasia	http://purl.obolibrary.org/obo/MPATH_599	developmental process abnormalities		Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth.
http://purl.obolibrary.org/obo/MPATH_66	dilatation	http://purl.obolibrary.org/obo/MPATH_56	developmental or adult structural  defect		Increase in the diameter of an orifice or tubular structure beyond its normal dimensions.
http://purl.obolibrary.org/obo/MPATH_86	organ specific developmental defect	http://purl.obolibrary.org/obo/MPATH_55	developmental and structural abnormality		Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations.
http://purl.obolibrary.org/obo/MPATH_89	cardiovascular developmental defect	http://purl.obolibrary.org/obo/MPATH_86	organ specific developmental defect		Abnormal development of the heart or vascular tissue resulting in morphological abnormality.
http://purl.obolibrary.org/obo/NBO_0000001	body part movement	http://purl.obolibrary.org/obo/NBO_0000338	kinesthetic behavior		A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC]
http://purl.obolibrary.org/obo/NBO_0000007	mouth movement	http://purl.obolibrary.org/obo/NBO_0000001	body part movement		The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC]
http://purl.obolibrary.org/obo/NBO_0000079	feeding behavior	http://purl.obolibrary.org/obo/NBO_0001845	consumption behavior		The act of bringing an object or substance into the body by swallowing, surrounding or absorbing it [NBO:SMAC]
http://purl.obolibrary.org/obo/NBO_0000314	visual behavior	http://purl.obolibrary.org/obo/NBO_0000308	sensation behavior		"Behavior related to the actions or reactions of an organism in response to a visual stimulus." [GO:0007632]
http://purl.obolibrary.org/obo/NBO_0000338	kinesthetic behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		"Movement behavior of the body or its parts."
http://purl.obolibrary.org/obo/NBO_0000339	motor coordination	http://purl.obolibrary.org/obo/NBO_0000317	vestibular behavior		"The coordination of combinations of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions." [wikipedia:Motor_coordination]
http://purl.obolibrary.org/obo/NBO_0000469	stress related behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		"Behavior related to how the body reacts to a stressor ( a stimulus that causes stress), real or imagined." [wikipedia:Stress_(biological)]
http://purl.obolibrary.org/obo/NBO_0000610	auditory hallucination	http://purl.obolibrary.org/obo/NBO_0000608	hallucination		"A form of hallucination that involves perceiving sounds without auditory stimulus." [wikipedia:Auditory_hallucination]
http://purl.obolibrary.org/obo/NBO_0000613	nonverbal communication behavior	http://purl.obolibrary.org/obo/NBO_0000612	communication behavior		"Communication behavior related to the process of conveying meaning in the form of non-word messages through for example gesture, body language or posture; facial expression and eye contact etc." [wikipedia:.wikipedia.org/wiki/Nonverbal_communication]
http://purl.obolibrary.org/obo/NBO_0001786	regulation of behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		"Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GO:0050795]
http://purl.obolibrary.org/obo/NBO_0000316	auditory behavior	http://purl.obolibrary.org/obo/NBO_0000308	sensation behavior		"Behavior related to the actions or reactions of an organism in response to a sound." [GO:0031223]
http://purl.obolibrary.org/obo/UBERON_0036074	vein of vestibular aqueduct	http://purl.obolibrary.org/obo/UBERON_0001638	vein		A vein that leaves the vestibule through an individual bone canal running parallel to the vestibular aqueduct up to the dura of the posterior side of the petrosa in the area of the endolymphatic sac. It then opens in the inferior petrosal sinus or the jugular bulb. The vein receives other branches from the bone, dura and sac.
http://purl.obolibrary.org/obo/GO_1905951	mitochondrion DNA recombination	http://purl.obolibrary.org/obo/GO_0006310	DNA recombination		Any DNA recombination that takes place in mitochondrion.
http://purl.obolibrary.org/obo/HP_0020071	Viremia	http://purl.obolibrary.org/obo/HP_0031863	Bloodstream infectious agent		The presence of virus in the blood.
http://purl.obolibrary.org/obo/HP_0020072	Persistent EBV viremia	http://purl.obolibrary.org/obo/HP_0032248	Persistent viremia		Persistent or recurrent detection of Epstein-Barr virus (EBV) in the blood that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_0032173	Continuous diaphragm sign	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		This sign is seen in pneumomediastinum in which air accumulates between the lower border of the heart and the superior part of the diaphragm, which results in complete visualization of the diaphragm in chest X-ray, hence named continuous diaphragm sign.
http://purl.obolibrary.org/obo/HP_0032174	Tree-in-bud pattern	http://purl.obolibrary.org/obo/HP_0033775	Pulmonary imaging sign		The tree-in-bud pattern represents centrilobular branching structures that resemble a budding tree. The pattern reflects a spectrum of endo- and peribronchiolar disorders, including mucoid impaction, inflammation, and/or fibrosis (See Figure 70 of PMID:18195376).
http://purl.obolibrary.org/obo/HP_0032175	Signet ring sign	http://purl.obolibrary.org/obo/HP_0033775	Pulmonary imaging sign		This finding is composed of a ring-shaped opacity representing a dilated bronchus in cross section and a smaller adjacent opacity representing its pulmonary artery, with the combination resembling a signet (or pearl) ring. It is the basic sign of bronchiectasis in pulmonary computed tomography imaging.
http://purl.obolibrary.org/obo/HP_0032176	Apical pulmonary opacity	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		An apical cap is a caplike lesion at the lung apex, usually caused by intrapulmonary and pleural fibrosis pulling down extrapleural fat or possibly by chronic ischemia resulting in hyaline plaque formation on the visceral pleura. The prevalence increases with age. It can also be seen in hematoma resulting from aortic rupture or in other fluid collection associated with infection or tumor, either outside the parietal pleura or loculated within the pleural space.
http://purl.obolibrary.org/obo/HP_0032177	Parenchymal consolidation	http://purl.obolibrary.org/obo/HP_0031457	Pulmonary opacity		Consolidation refers to an exudate or other product of disease that replaces alveolar air, rendering the lung solid (as in infective pneumonia).
http://purl.obolibrary.org/obo/HP_0032178	Flaky paint dermatosis	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		A dermatosis characterized by generalized shiny, enamel-like, hyperpigmented scales in an irregular pattern. The scales may peel or desquamate, rather like old, sun-baked blistered paint, often with areas of underlying hypopigmentation. This has led to the terms peeling paint or flaky paint dermatosis (See the Figure in PMID:24285001).
http://purl.obolibrary.org/obo/HP_0032181	Anomalous hepatic venous drainage into the left atrium	http://purl.obolibrary.org/obo/HP_0006707	Abnormality of the hepatic vasculature		An abnormality of the hepatic veins, which normally drain de-oxygenated blood from the liver into the inferior vena cava, whereby the hepatic veins drain into the left atrium.
http://purl.obolibrary.org/obo/HP_0032182	Abnormal memory T cell proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		An abnormal proportion of memory T cells compared to the total number of T cells in the blood. Memory T cells have previously encountered and responded to their cognate antigen and upon a repeated encounter with the antigen can mount a faster and stronger response.
http://purl.obolibrary.org/obo/HP_0032183	Decreased memory T cell proportion	http://purl.obolibrary.org/obo/HP_0032182	Abnormal memory T cell proportion		An abnormally reduced proportion of memory T cells compared to the total number of T cells in the blood.
http://purl.obolibrary.org/obo/HP_0032184	Increased memory T cell proportion	http://purl.obolibrary.org/obo/HP_0032182	Abnormal memory T cell proportion		An abnormally elevated proportion of memory T cells compared to the total number of T cells in the blood.
http://purl.obolibrary.org/obo/HP_0032185	Disseminated molluscum contagiosum	http://purl.obolibrary.org/obo/HP_0032163	Unusual molluscum contagiosum		Increased susceptibility to Molluscum contagiosum infections as manifested by a severe, invasive, or disseminated infection with Molluscum contagiosum over the body.
http://purl.obolibrary.org/obo/HP_0032186	Anal neoplasm	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		A benign or malignant neoplasm that affects the anal canal or anal margin.
http://purl.obolibrary.org/obo/HP_0032187	Anal intraepithelial neoplasia	http://purl.obolibrary.org/obo/HP_0032186	Anal neoplasm		Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer.
http://purl.obolibrary.org/obo/HP_0032188	Cellular hypersensitivity to mitomycin C	http://purl.obolibrary.org/obo/HP_0003254	Abnormality of DNA repair		An increased cellular sensitivity to the DNA cross-linking agent, mitomycin C (MMC). In the presence of increased sensitivity, MMC causes increased cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle.
http://purl.obolibrary.org/obo/HP_0032189	Cellular hypersensitivity to diepoxybutane	http://purl.obolibrary.org/obo/HP_0003254	Abnormality of DNA repair		An increased cellular sensitivity to the DNA cross-linking agent, diepoxybutane (DEB). In the presence of increased sensitivity, DEB causes cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle.
http://purl.obolibrary.org/obo/HP_0032190	Abnormal meniscus morphology	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		Abnormal structure of the meniscus of the knee, two crescent shape fibrocartilaginous pads that disperse the weight of the body and reduce friction of the knee joint during movement.
http://purl.obolibrary.org/obo/HP_0032191	Torn meniscus	http://purl.obolibrary.org/obo/HP_0032190	Abnormal meniscus morphology		A tear in the cartilaginous pad (meniscus) of the knee.
http://purl.obolibrary.org/obo/HP_0032192	Hydatidiform mole	http://purl.obolibrary.org/obo/HP_0001194	Abnormalities of placenta or umbilical cord		Hydatidiform mole (HM) is an aberrant human pregnancy with absence of, or abnormal embryonic development, hydropic degeneration of chorionic villi, and excessive proliferation of the trophoblast.
http://purl.obolibrary.org/obo/HP_0032193	Decreased low-density lipoprotein particle size	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		An abnormal decrease in the average size of low-density lipoprotein particle size in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032195	Abnormal S wave	http://purl.obolibrary.org/obo/HP_0012249	Abnormal ST segment		Any anomaly of the S wave, which is the third component of the QRS wave complex. The S wave signifies the final depolarization of the ventricles at the base of the heart.
http://purl.obolibrary.org/obo/HP_0032196	Prominent S wave in lead I	http://purl.obolibrary.org/obo/HP_0032195	Abnormal S wave		Increased amplitude (0.1 mV or more) and/or duration (40 ms or more) of the S wave as measured in lead I of the electrocardiogram.
http://purl.obolibrary.org/obo/HP_0032197	Deep S wave in lead V5	http://purl.obolibrary.org/obo/HP_0032195	Abnormal S wave		Abnormal depth of the S wave in lead V5 of the electrocardiogram.
http://purl.obolibrary.org/obo/HP_0032198	Decreased prothrombin time	http://purl.obolibrary.org/obo/HP_0032199	Abnormal prothrombin time		Abnormally short time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.
http://purl.obolibrary.org/obo/HP_0032200	Perivascular fibrosis	http://purl.obolibrary.org/obo/HP_0033353	Abnormal blood vessel morphology		The presence of thick collagen bundles around blood vessels, often in an onion-skin type whorling pattern.
http://purl.obolibrary.org/obo/HP_0032201	Rotator cuff tear	http://purl.obolibrary.org/obo/HP_0100261	Abnormal tendon morphology		The term rotator cuff describes the tendons connecting the infraspinatus, supraspinatus, teres minor, and subscapularis muscles to the humeral head.Traumatic tears of the rotator cuff tend to occur at the tendon-bone junction of the supraspinatus and greater tuberosity of the humerus whereas degenerative tears tend to be seen posteriorly at the junction of the supraspinatus and infraspinatu A rotator cuff tear is when one or more of these tendons tears or detaches from the humerus.
http://purl.obolibrary.org/obo/HP_0032202	Vulvar intraepithelial neoplasia	http://purl.obolibrary.org/obo/HP_0030416	Vulvar neoplasm		Vulvar intraepithelial neoplasia (VIN) is widely accepted as the precursor lesion of vulvar squamous cell carcinoma (VSCC). VSCC arises via either a human papilloma virus (HPV)-associated pathway, or more commonly, via a mechanism independent of HPV, often being linked to chronic inflammatory conditions such as lichen sclerosus (LS). Accordingly, two distinct subtypes of VIN are recognized: the HPV-associated high-grade squamous intraepithelial lesion/usual VIN (HSIL/uVIN) and the non-HPV-associated differentiated VIN (dVIN). HSIL is clinically identified by its multifocal, warty appearance and on histology by conspicuous cytological and architectural atypia. Differentiated VIN, on the other hand, often produces ill-defined lesions, and on histology, notoriously mimics non-neoplastic epithelial disorders (NNED), particularly LS. As a result, dVIN is rarely identified in advance of a diagnosis of invasive malignancy, despite being the precursor lesion of the majority of VSCC.
http://purl.obolibrary.org/obo/HP_0032203	Lymphoid nodular hyperplasia	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		Lymphoid nodular hyperplasia (LNH) of the terminal ileum and colon has been considered a mucosal response to nonspecific stimuli, most often infections, and consequently has been regarded as a pathophysiologic phenomenon during infancy and childhood. LNH can be ascertained by colonoscopy, whereby a lymphoid nodule is defined as an extruding follicle with a diameter of not more than 2 mm, and LNH is defined as a cluster of not more than 10 of such extruding lymphoid nodules (see Figure 1 of PMID:17368236).
http://purl.obolibrary.org/obo/HP_0032204	Chronic active EBV infection	http://purl.obolibrary.org/obo/HP_0031035	Chronic infection		Chronic active Epstein-Barr virus (EBV) infection is an uncommon outcome of EBV infection and may present as a waxing and waning or fulminant syndrome. Unlike acute infectious mononucleosis, wherein EBV establishes lifelong infection and survives by maintaining a delicate balance with the host as a latent infection, in chronic active EBV infection the host-virus balance is disturbed.
http://purl.obolibrary.org/obo/HP_0032205	Elevated circulating galectin-3 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of galectin-3 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032208	Increased urinary type 1 collagen N-terminal telopeptide level	http://purl.obolibrary.org/obo/HP_0033384	Elevated urinary collagen degradation products		An increased concentration of type 1 collagen N-terminal telopeptide (NTx) level in the urine. Generally the test is performed over a period of time, for instance, 10 cc of morning urine can be collected following 12 hours overnight fasting or for 24 hours.
http://purl.obolibrary.org/obo/HP_0032209	Abnormal circulating free T3 concentration	http://purl.obolibrary.org/obo/HP_0031508	Abnormal circulating thyroid hormone concentration		A deviation from the normal concentration of free triiodothyronine (T3) in the blood circulation. A proportion of T3 is bound to plasma proteins in the blood, including mainly thyroxine binding globulin, transthyretin, and albumin. T3 that is not bound to a protein is referred to as free T3.
http://purl.obolibrary.org/obo/HP_0032210	Decreased circulating free T3	http://purl.obolibrary.org/obo/HP_0032209	Abnormal circulating free T3 concentration		A reduced concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032211	Increased urinary epithelial cell count	http://purl.obolibrary.org/obo/HP_0012614	Abnormal urine cytology		An increased number of epithelial cells per high-power field in urinanalysis.
http://purl.obolibrary.org/obo/HP_0032212	Increased urinary squamous epithelial cell count	http://purl.obolibrary.org/obo/HP_0032211	Increased urinary epithelial cell count		An increased number of squamous epithelial cells per high-power field in urinanalysis.
http://purl.obolibrary.org/obo/HP_0032213	Increased urinary renal tubular epithelial cell count	http://purl.obolibrary.org/obo/HP_0032211	Increased urinary epithelial cell count		An increased number of renal tubular epithelial cells per high-power field in urinanalysis.
http://purl.obolibrary.org/obo/HP_0032214	Increased urinary transitional epithelial cell count	http://purl.obolibrary.org/obo/HP_0032211	Increased urinary epithelial cell count		An increased number of transitional epithelial cells per high-power field in urinanalysis.
http://purl.obolibrary.org/obo/HP_0032215	Disseminated cutaneous warts	http://purl.obolibrary.org/obo/HP_0200043	Verrucae		Multiple skin warts located in multiple parts of the body, e.g., neck, trunks, and extremities.
http://purl.obolibrary.org/obo/HP_0032216	Lymphocytic infiltration of the colorectal mucosa	http://purl.obolibrary.org/obo/HP_0025090	Abnormal large intestinal mucosa morphology		Abnormally increased intraepithelial lymphocyte count. This finding may be appreciated as large numbers of surface intraepithelial lymphocytes as seen (for instance) with hematoxylin and eosin staining of a colonic biopsy sample taken during colonoscopy.
http://purl.obolibrary.org/obo/HP_0032217	Indurated nodule	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		A skin nodule that is unusually hard (indurated).
http://purl.obolibrary.org/obo/HP_0032218	Decreased total CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_5210415	Decreased total CD4+ T cell number		Abnormal decrease of helper CD3+CD4+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0032219	Increased total CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_5210416	Increased CD4+ T cell number		Abnormal increase of helper CD3+CD4+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0032220	Interface hepatitis	http://purl.obolibrary.org/obo/HP_0012115	Hepatitis		Inflammation of the liver characterized by a mononuclear cell infiltrate whereby portal inflammatory cells extend through the limiting plate between the portal tract and liver parenchyma.
http://purl.obolibrary.org/obo/HP_0032221	Periportal emperipolesis	http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology		The engulfing of lymphocytes by hepatocytes, which typically occurs in the interface hepatitis area.
http://purl.obolibrary.org/obo/HP_0032222	Serrated intestinal polyps	http://purl.obolibrary.org/obo/HP_0200008	Intestinal polyposis		The presence of multiple serrated polyps in the intestine. Unlike conventional adenomas, which are uniformly dysplastic, the vast majority of serrated lesions contain no dysplasia. The serrated class includes the hyperplastic polyps, which are not considered precancerous; sessile serrated polyps (also called sessile serrated adenomas); and traditional serrated adenomas. Sessile serrated polyps are larger on average and more often located in the proximal colon. Sessile serrated polyps have a more irregular surface, a pattern to the surface that has been called cloudlike, and indistinct edges compared with hyperplastic polyps. Sessile serrated polyps also have large open pits on the surface (type O pits) when viewed with magnification.
http://purl.obolibrary.org/obo/HP_0032223	Blood group	http://purl.obolibrary.org/obo/HP_0000001	All		Any of the various types of human blood whose antigen characteristics determine compatibility in transfusion. While the ABO and Rhesus systems are the most well known, there are in total about 300 different blood type antigens distributed across 34 different blood type systems.
http://purl.obolibrary.org/obo/HP_0032224	ABO blood group	http://purl.obolibrary.org/obo/HP_0032223	Blood group		The ABO system consists of A and B antigens and antibodies against these antigens.
http://purl.obolibrary.org/obo/HP_0032225	Perifollicular fibroma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		Perifollicular fibroma is a rare cutaneous hamartoma that shows differentiation in the connective tissue sheath of hair follicles. It can occur as a solitary papule or as multiple lesions. Histologically, the lesion consists of a concentric arrangement of cellular fibrous tissue around a normal hair follicle.
http://purl.obolibrary.org/obo/HP_0032226	Abnormal sebaceous gland morphology	http://purl.obolibrary.org/obo/HP_0011138	Abnormal skin adnexa morphology		Any structural anomaly of the sebaceous glands.
http://purl.obolibrary.org/obo/HP_0032227	Sebaceous hyperplasia	http://purl.obolibrary.org/obo/HP_0032226	Abnormal sebaceous gland morphology		A common, benign skin condition involving hypertrophy of the sebaceous glands characterized by single or multiple lesions that manifest as yellow, soft, small papules with umbilication. The lesions are located commonly on the central face (specifically, the nose, cheeks and forehead) but may also occur elsewhere, including the chest, mouth, scrotum, foreskin, penile shaft, vulva, and areola.
http://purl.obolibrary.org/obo/HP_0032228	Trichodiscoma	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		A small benign fibrovascular tumor of the dermal part of the hair disk. Trichodiscoma is rather simple in appearance and consists of a dome-shaped fibrous tumor with a prominent vascular component that fills the papillary dermis under an atrophic epidermis. As in a normal hair disk, a hair follicle may be present at one edge of the papular lesion.
http://purl.obolibrary.org/obo/HP_0032229	Perinuclear antineutrophil antibody positivity	http://purl.obolibrary.org/obo/HP_0003453	Antineutrophil antibody positivity		The presence of autoantibodies in the serum that react against proteins predominantly expressed in perinuclear region of neutrophils.
http://purl.obolibrary.org/obo/HP_0032230	Cytoplasmic antineutrophil antibody positivity	http://purl.obolibrary.org/obo/HP_0003453	Antineutrophil antibody positivity		The presence of autoantibodies in the serum that react against proteins predominantly expressed in cytoplasmic granules of neutrophils.
http://purl.obolibrary.org/obo/HP_0032231	Hypochromia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		A qualitative impression that red blood cells have less color than normal when examined under a microscope, usually related to a reduced amount of hemoglobin in the red blood cells.
http://purl.obolibrary.org/obo/HP_0032232	Elevated circulating CK-MB concentration	http://purl.obolibrary.org/obo/HP_0040081	Abnormal circulating creatine kinase activity		The concentration of CK-MB (= creatine kinase MB) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032233	Elevated circulating creatine kinase BB isoform concentration	http://purl.obolibrary.org/obo/HP_0040081	Abnormal circulating creatine kinase activity		The concentration of creatine kinase BB isoform in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032234	Elevated circulating creatine kinase MM isoform concentration	http://purl.obolibrary.org/obo/HP_0040081	Abnormal circulating creatine kinase activity		The concentration of creatine kinase MM isoform in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032235	Anti-La/SS-B antibody positivity	http://purl.obolibrary.org/obo/HP_0033476	Extractable nuclear antigen positivity		The presence of autoantibodies in the blood circulation that react against La/SSB autoantigens.
http://purl.obolibrary.org/obo/HP_0032236	Increased circulating immature neutrophil count	http://purl.obolibrary.org/obo/HP_0032309	Abnormal granulocyte count		An abnormally increased number of immature neutrophils in the peripheral blood circulation.
http://purl.obolibrary.org/obo/HP_0032237	Increased circulating myelocyte count	http://purl.obolibrary.org/obo/HP_0032236	Increased circulating immature neutrophil count		The number of myelocytes in the peripheral blood circulation is above the upper limit of normal. Myelocytes are immature neutrophils with a size of 12-18 micrometers, a round or oval nucleus with no nucleoli, bluish-pink staining cytoplasm with primary and secondary granules, and a nucleus:cytoplasm ratio of 2:1.
http://purl.obolibrary.org/obo/HP_0032238	Increased circulating metamyelocyte count	http://purl.obolibrary.org/obo/HP_0032236	Increased circulating immature neutrophil count		The number of metamyelocytes in the peripheral blood circulation is above the upper limit of normal. Metamyelocytes are immature neutrophils with a size of 10-18 micrometers, an indented or kidney-shaped nucleus, pinkish-blue staining cytoplasm with secondary granules, and a nucleus:cytoplasm ratio of 1.5:1.
http://purl.obolibrary.org/obo/HP_0032239	Increased circulating band cell count	http://purl.obolibrary.org/obo/HP_0032236	Increased circulating immature neutrophil count		The number of band cells in the peripheral blood circulation is above the upper limit of normal. Band cells are immature neutrophils with a size of 10-18 micrometers, a horseshoe-shaped nucleus with no nucleoli, light-pink staining cytoplasm with many small secondary granules, and a nucleus:cytoplasm ratio of 1:2.
http://purl.obolibrary.org/obo/HP_0032240	Elevated circulating E-selectin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of E-selectin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032241	Cervical neoplasm	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		A tumor (abnormal growth of tissue) of the uterine cervix.
http://purl.obolibrary.org/obo/HP_0032242	Cervical intraepithelial neoplasia	http://purl.obolibrary.org/obo/HP_0032241	Cervical neoplasm		A precancerous condition characterized by dysplasia of the cervical epithelium. Cervical intraepithelial neoplasia (CIN) 1, 2 and 3 based on its relationship with the prognosis. CIN 1 is mild dysplasia, which is mostly observed because it disappears as part of its natural course. CIN 3 includes severe dysplasia and carcinoma in situ, and management involves treatment because it is highly likely to develop into invasive cancer.
http://purl.obolibrary.org/obo/HP_0032244	Decreased serum thromboxane B2	http://purl.obolibrary.org/obo/HP_0030389	Abnormal circulating thromboxane concentration		A reduction in the concentration of thromboxane B2 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032247	Persistent CMV viremia	http://purl.obolibrary.org/obo/HP_0032248	Persistent viremia		Persistent or recurrent detection of cytomegalovirus (CMV) in the blood that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_0032248	Persistent viremia	http://purl.obolibrary.org/obo/HP_0032169	Severe infection		Persistence of virus in the blood circulation longer than would be normal in an immunocompetent host.
http://purl.obolibrary.org/obo/HP_0032249	Coccidioidomycosis	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		Infection by a Coccidioides species fungus. These are dimorphic, soil-dwelling, fungi known to cause a broad spectrum of disease, ranging from a mild febrile illness to severe pulmonary manifestations or disseminated disease. The genus Coccidioides is comprised of two genetically distinct species: Coccidioides immitis and C. posadasii.
http://purl.obolibrary.org/obo/HP_0032250	Acinetobacter infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		An infection by Acinetobacter baumannii, a Gram-negative bacillus that is aerobic, pleomorphic and non-motile. An opportunistic pathogen, A. baumannii has a high incidence among immunocompromised individuals, particularly those who have experienced a prolonged (over 90 d) hospital stay.
http://purl.obolibrary.org/obo/HP_0032252	Granuloma	http://purl.obolibrary.org/obo/HP_0032251	Abnormal immune system morphology		A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.
http://purl.obolibrary.org/obo/HP_0032253	Eosinophilic granuloma	http://purl.obolibrary.org/obo/HP_0032252	Granuloma		A type of granuloma characterized morphologically by the predominance of Langerhans cells with characteristic grooved, folded, indented nuclei in the appropriate milieu that includes variable numbers of eosinophils and histiocytes including multinucleated forms, often appearing similar to osteoclasts or touton like giant cells, neutrophils and small lymphocytes. The concentration of the eosinophilic infiltrate varies from scattered mature cells to sheet-like masses of cells. Occasionally, areas of bone necrosis may interrupt the cellular infiltrate. The foamy cells may also be amassed in clumps, which are of no clinical significance because these clumps represent phagocytosis of lipid debris.
http://purl.obolibrary.org/obo/HP_0032254	Elevated circulating copper concentration	http://purl.obolibrary.org/obo/HP_0010836	Abnormal circulating copper concentration		The concentration of copper cation in the blood circulation is above the upper limit of normal. This term refers to the total copper concentration.
http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		An infection that is caused by a fungus that would generally not be able to cause an infection in a host with a normal immune system. Such fungi take advantage of the opportunity, so to speak, that is provided by a weakened immune system.
http://purl.obolibrary.org/obo/HP_0032256	Unusual Histoplasma capsulatum infection	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An increased susceptibility to Histoplasma capsulatum infections as manifested by a recurrent or severe/invasive infection with Histoplasma capsulatum, or occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_0032257	Severe Histoplasma capsulatum infection	http://purl.obolibrary.org/obo/HP_0032256	Unusual Histoplasma capsulatum infection		Histoplasmosis infection involving multiple sites of the body. Disseminated histoplasmosis can involve various organs, including reticuloendothelial organs, gastrointestinal tract, adrenal glands, central nervous system, endovascular structures, kidney, and skin. It typically presents with systemic symptoms like fever, generalized fatigue, night sweats, weight loss, and the symptoms related to the specific organ involved. Severe disseminated disease can manifest as septic shock, multi organ failure, and ARDS.
http://purl.obolibrary.org/obo/HP_0032258	Pulmonary histoplasmosis	http://purl.obolibrary.org/obo/HP_0032256	Unusual Histoplasma capsulatum infection		Infection of the lungs with Histoplasma capsulatum. Symptoms may include fever, headache, weakness, chest pain and dry cough. When imaging is done, chest radiographs may show patchy pneumonia involving one or more lobes with adenopathy of the mediastinum or hilum.
http://purl.obolibrary.org/obo/HP_0032259	Chronic tinea infection	http://purl.obolibrary.org/obo/HP_0031035	Chronic infection		The term tinea means fungal infection, whereas dermatophyte refers to the fungal organisms that cause tinea. This term refers to a tinea infection that is chronic or recalcitrant to treatment and may be reflective of an immune defect.
http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection	http://purl.obolibrary.org/obo/HP_0031690	Opportunistic infection		An infection that is caused by a bacterium that would generally not be able to cause an infection in a host with a normal immune system. Such bacteria take advantage of the opportunity, so to speak, that is provided by a weakened immune system.
http://purl.obolibrary.org/obo/HP_0032261	Nontuberculous mycobacterial pulmonary infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		An infection of the lung caused by environmental mycobacteria. Such infections can occur in individuals with predisposing lung disease or immune disease.
http://purl.obolibrary.org/obo/HP_0032262	Pulmonary tuberculosis	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		A lung infection by Mycobacterium tuberculosis a slightly curved non-motile, aerobic, non-capsulated and non-spore forming strains of mycobacteria.
http://purl.obolibrary.org/obo/HP_0032264	Anti-NMDA receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor.
http://purl.obolibrary.org/obo/HP_0032265	CSF autoimmune antibody positivity	http://purl.obolibrary.org/obo/HP_0002960	Autoimmunity		The presence of an antibody in the cerebrospinal fluid (CSF) that is directed against the organism's own cells or tissues.
http://purl.obolibrary.org/obo/HP_0032266	CSF anti-NMDA receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0032265	CSF autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the cerebrospinal fluid (CSF) that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor.
http://purl.obolibrary.org/obo/HP_0032267	Empty delta sign	http://purl.obolibrary.org/obo/HP_0010303	Abnormal spinal meningeal morphology		This sign is created by a nonenhancing thrombus in the dural sinus surrounded by triangular enhancing dura as seen on cross-section. The sign, seen on contrast-enhanced CT scan images, suggests dural sinovenous thrombosis. It is best seen on wider window settings. It is a reliable sign of sinus thrombosis but is seen only in 25-30% of these cases.
http://purl.obolibrary.org/obo/HP_0032268	Dural tail sign	http://purl.obolibrary.org/obo/HP_0010303	Abnormal spinal meningeal morphology		This sign represents thickening and enhancement of the dura mater in continuity with a mass, which on MR images, gives the appearance of a tail arising from the mass. The dural tail is thought to represent reactive change; however, it may also be due to tumor invasion. Three criteria need to be met for a positive dural tail sign: the tail should be seen on two successive images through the tumor, it should taper away from the tumor, and it must enhance more than the tumor.
http://purl.obolibrary.org/obo/HP_0032269	Lemon sign	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		The lemon sign refers to the shape of the fetal skull at ultrasonography (US) when the frontal bones lose their normal convex contour and appear flattened or inwardly scalloped. This gives the skull a shape that is said to resemble a lemon.. The sign is seen on transverse sonograms of the fetal cranium obtained at the level of the ventricles.
http://purl.obolibrary.org/obo/HP_0032270	Optic nerve tram-track sign	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		A tram-track sign is composed of two enhancing areas of tumor separated from each other by the negative defect of the optic nerve. It is seen on contrast-enhanced CT scan and MRI images, in optic nerve sheath meningioma. The sign helps distinguish between optic nerve sheath meningioma and optic glioma. Optic glioma arises from glial cells within the optic nerve and there is no clear separation between the nerve and the tumor; hence the tram-track sign is not seen in optic gliomas. Calcification may be seen in optic nerve sheath meningiomas in 20-50% of cases and hence the tram-track sign may be seen on nonenhanced CT scan images as a linear calcification around the nerve, but this is less common.
http://purl.obolibrary.org/obo/HP_0032271	Extrapulmonary tuberculosis	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		A type of tubercular infection located outside of the lung, which is the most common location of tuberculosis. There are two types of clinical manifestation of tuberculosis (TB) are pulmonary TB (PTB) and extrapulmonary TB (EPTB). The former is most common. EPTB refers to TB involving organs other than the lungs (e.g., pleura, lymph nodes, abdomen, genitourinary tract, skin, joints and bones, or meninges). A patient with both pulmonary and EPTB is classified as a case of PTB.
http://purl.obolibrary.org/obo/HP_0032273	Increased circulating N-acetylaspartic acid concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		Concentration of N-acetylaspartic acid in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032274	Increased CSF N-acetylaspartic acid concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		An abnormally increased concentration of N-acetylaspartic acid in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0032275	Recurrent shingles	http://purl.obolibrary.org/obo/HP_0005353	Recurrent herpes		Repeated episodes of a localized, painful cutaneous eruption related to reactivation of varicella zoster virus (VZV) and characterized by a characteristic rash in one or two adjacent dermatomes.
http://purl.obolibrary.org/obo/HP_0032276	Prominent subcalcaneal fat pad	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		Abnormally increased prominence of the fat pad underneath the heal. This feature can be appreciated in figure 1 of PMID:26769062.
http://purl.obolibrary.org/obo/HP_0032278	2-hydroxyglutarate aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of 2-hydroxyglutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032281	Abnormal base excess	http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis		Deviation from the normal quantity of base excess, defined as the amount of strong acid (in millimoles per liter) that needs to be added in vitro to 1 liter of fully oxygenated whole blood to return a blood sample to standard conditions (pH of 7.40, Pco2 of 40 mm Hg, and temperature of 37 degrees C).
http://purl.obolibrary.org/obo/HP_0032282	Contact dermatitis	http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis		An inflammatory process in skin caused by an exogenous agent that directly or indirectly injure the skin. If the offending agent is identified and removed, the eruption will resolve. An unusual or patterned eruption may be a clue to the presence of a contact dermatitis. Patch testing may be helpful in the differential diagnosis.
http://purl.obolibrary.org/obo/HP_0032283	Disseminated non-tuberculous mycobacterial infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Disseminated infection with non-tuberculous mycobacteria (NTM), involving multiple organ systems that occurs in the context of immune deficiency.
http://purl.obolibrary.org/obo/HP_0032284	Ultra-low vision with retained motion projection	http://purl.obolibrary.org/obo/HP_0032123	Ultra-low vision		Ultra-low vision but with retained ability to identify a moving object (typically hand motion at distance of 30 cm).
http://purl.obolibrary.org/obo/HP_0032285	Ultra-low vision with retained light projection	http://purl.obolibrary.org/obo/HP_0032123	Ultra-low vision		Ultra-low vision but with retained ability to perceive the difference between light and dark. Also when light is projected in each of the four quadrants of the visual field, the individual is able to correctly identify the origin of the light stimulus.
http://purl.obolibrary.org/obo/HP_0032286	Ultra-low vision with retained light perception	http://purl.obolibrary.org/obo/HP_0032123	Ultra-low vision		Ultra-low vision but with retained ability to perceive the difference between light and dark.
http://purl.obolibrary.org/obo/HP_0032287	Ultra-low vision with no light perception	http://purl.obolibrary.org/obo/HP_0032123	Ultra-low vision		Ultra-low vision with complete lack of light and form perception.
http://purl.obolibrary.org/obo/HP_0410292	Abnormal circulating isohemagglutinin concentration	http://purl.obolibrary.org/obo/HP_0012475	Impaired specific antibody response		An abnormal level of isohemagglutinin in the blood. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person).
http://purl.obolibrary.org/obo/HP_0033028	Anti-U1 ribonucleoprotein antibody positivity	http://purl.obolibrary.org/obo/HP_0033476	Extractable nuclear antigen positivity		The presence autoantibodies in the serum that react to proteins (70 Kd, A, C) that are associated with U1 RNA and form U1snRNP.
http://purl.obolibrary.org/obo/HP_0033030	Anti-glomerular basement membrane-antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react to the glomerular basement membrane.
http://purl.obolibrary.org/obo/HP_0033031	Hyperpyrexia	http://purl.obolibrary.org/obo/HP_0001945	Fever		An extreme elevation of core body temperature above normal defined as a rectal temperature of 41.1 degrees Celsius (106 degrees Fahrenheit).
http://purl.obolibrary.org/obo/HP_0033032	Triggered by an abusive adult	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is induced by an abusive adult (usually a parent).
http://purl.obolibrary.org/obo/HP_0033033	Anti-MDA5 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react to Anti-MDA5 (Anti-melanoma differentiation-associated proteine 5).
http://purl.obolibrary.org/obo/HP_0033034	Anti-citrullinated protein antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence autoantibodies in the serum that react do different citrullinated antigens, including filaggrin, fibrinogen, vimentin and collagen.
http://purl.obolibrary.org/obo/HP_0033035	Abnormal Schwann cell morphology	http://purl.obolibrary.org/obo/HP_0100705	Abnormal glial cell morphology		Abnormality of schwann cells, glial cells that ensheath axons of neurons in the peripheral nervous system and are necessary for their maintenance and function.
http://purl.obolibrary.org/obo/HP_0033036	Decreased nasal nitric oxide	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Reduced level of nasal nitric oxide (nNO). Current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines for nNO measurements recommend air aspiration via a nasal probe while the subject exhales through the mouth against resistance in order to maintain velum closure.
http://purl.obolibrary.org/obo/HP_0033038	Anti-RNA-polymerase-III-autoantibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react to RNA-polymerase III.
http://purl.obolibrary.org/obo/HP_0033039	Increased circulating precipitin concentration	http://purl.obolibrary.org/obo/HP_0012224	Circulating immune complexes		The concentration (titer) of antigen-precipitating IgG in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033040	Anti-Sm antibody positivity	http://purl.obolibrary.org/obo/HP_0033476	Extractable nuclear antigen positivity		The presence of autoantibodies in the serum that react to seven proteins that consist of a core of small nuclear ribonucleoprotein (snRNP) particles.
http://purl.obolibrary.org/obo/HP_0033041	Cytokine storm	http://purl.obolibrary.org/obo/HP_0011113	Abnormality of cytokine secretion		Excessive or uncontrolled release of proinflammatory cytokines.
http://purl.obolibrary.org/obo/HP_0033042	Abnormal chorion morphology	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Any structural anomaly of the fetal part of the placenta, which is known as the chorion.
http://purl.obolibrary.org/obo/HP_0033043	Edematous chorionic villi	http://purl.obolibrary.org/obo/HP_0033042	Abnormal chorion morphology		Swelling of the chorionic villi owing to fluid accumulation.
http://purl.obolibrary.org/obo/HP_0033044	Motor regression	http://purl.obolibrary.org/obo/HP_0002376	Developmental regression		Loss of previously achieved motor skills, as manifested by loss of developmental motor milestones.
http://purl.obolibrary.org/obo/HP_0033045	Bipedal edema	http://purl.obolibrary.org/obo/HP_0010741	Pedal edema		A palpable swelling in both feet and ankles caused by an increase in interstitial fluid volume (excess fluid).
http://purl.obolibrary.org/obo/HP_0033046	Michaelis-Gutmann bodies	http://purl.obolibrary.org/obo/HP_0004311	Abnormal macrophage morphology		Basophilic intracytoplasmic inclusions in macrophages. The inclusions have a small, round laminated appearance. Electron microscopy of Michaelis-Gutmann bodies exhibits partially digested bacteria.
http://purl.obolibrary.org/obo/HP_0033047	Body ache	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Body ache is a complaint that is often used to denote vague symptoms of mild fatigue, lethargy, or dull aches. We will define it here to mean a dull and poorly localizable pain that is described by the affected individual to affect multiple joints or body parts or even the entire body.
http://purl.obolibrary.org/obo/HP_0033048	Substantia nigra hypointensity on susceptibility-weighted imaging	http://purl.obolibrary.org/obo/HP_0045007	Abnormal substantia nigra morphology		Hypointence (dark) appearance of the substantia nigra inmagnetic resonance imaging using susceptibility weighted imaging (SWI).
http://purl.obolibrary.org/obo/HP_0033049	Globus pallidus hypointensity on susceptibility-weighted imaging	http://purl.obolibrary.org/obo/HP_0002453	Abnormal globus pallidus morphology		Hypointence (dark) appearance of the globus pallidus inmagnetic resonance imaging using susceptibility weighted imaging (SWI).
http://purl.obolibrary.org/obo/HP_0033050	Pharyngalgia	http://purl.obolibrary.org/obo/HP_0033152	Abnormal pharynx physiology		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the throat.
http://purl.obolibrary.org/obo/HP_0033051	Impaired executive functioning	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia.
http://purl.obolibrary.org/obo/HP_0033052	Non-epileptic seizure	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		Psychogenic non-epileptic seizures (PNES) are not abnormal perceptions or abnormal beliefs/judgments, nor are they epileptic attacks. They are behaviors that simulate epileptic attacks, not fully consciously.
http://purl.obolibrary.org/obo/HP_0033053	Pseudoseizure	http://purl.obolibrary.org/obo/HP_0033052	Non-epileptic seizure		Sudden, involuntary seizure-like attacks that, unlike epileptic seizures, are not related to electrographic ictal discharges.
http://purl.obolibrary.org/obo/HP_0033054	Myoclonic tremor	http://purl.obolibrary.org/obo/HP_0040148	Cortical myoclonus		A tremor-like cortical myoclonus. The tremulous movements are in fact small, high-frequency myoclonic jerks, induced by posture or action. They can be mild, but can also be more incapacitating. When present in the lower limbs, these may lead to gait disorders and even drop attacks. These tremor-like movements during action can be mistaken for essential tremor or epileptic seizures.
http://purl.obolibrary.org/obo/HP_0033055	Impaired ability to plan	http://purl.obolibrary.org/obo/HP_0033051	Impaired executive functioning		Impaired ability to anticipate future events, implement instructions or goals, and develop appropriate steps ahead of time in order to carry out a task or activity.
http://purl.obolibrary.org/obo/HP_0033056	Impaired ability to organize	http://purl.obolibrary.org/obo/HP_0033051	Impaired executive functioning		Impaired ability to bring order to information, actions, or materials to achieve a goal or to follow an established organized routine.
http://purl.obolibrary.org/obo/HP_0033058	Decreased circulating complement C7 concentration	http://purl.obolibrary.org/obo/HP_0033057	Decreased circulating terminal complement component concentration		Concentration of the complement component C7 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033059	Decreased circulating complement C6 concentration	http://purl.obolibrary.org/obo/HP_0033057	Decreased circulating terminal complement component concentration		Concentration of the complement component C6 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033060	Decreased circulating complement C5 concentration	http://purl.obolibrary.org/obo/HP_0033057	Decreased circulating terminal complement component concentration		Concentration of the complement component C5 in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033061	Increased factor IX activity	http://purl.obolibrary.org/obo/HP_0033062	Abnormal factor IX activity		Elevated activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.
http://purl.obolibrary.org/obo/HP_0033063	Shortened sleep phase	http://purl.obolibrary.org/obo/HP_0006979	Sleep-wake cycle disturbance		A tendency to sleep fewer hours than usual while feeling well-rested.
http://purl.obolibrary.org/obo/HP_0033064	Renal interstitial globotriaosylceramide inclusions	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Accumulation of globotriaosylceramide (GL-3) in kidney tissues, which can be quantified as the number of globotriaosylceramide (GL-3) inclusions/kidney interstitial capillary (KIC).
http://purl.obolibrary.org/obo/HP_0033065	Mild albuminuria	http://purl.obolibrary.org/obo/HP_0012592	Albuminuria		The presence of mildly increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio (ACR) less than 30 mg/gm (less than 3.4 mg/mmol).
http://purl.obolibrary.org/obo/HP_0033066	Severe albuminuria	http://purl.obolibrary.org/obo/HP_0012592	Albuminuria		The presence of severely increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio greater than 300 mg/gm (greater than 34 mg/mmol).
http://purl.obolibrary.org/obo/HP_0033068	Medication crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		A variety of drugs may occasionally cause transient crystalluria, in isolation or in conjunction with other urinary abnormalities. Overdose, dehydration, or hypoalbuminaemia, which increases the unbound drug which is ultrafiltrated by the glomerulus, are the factors usually favoring the precipitation of crystals within the tubular lumina. In some cases, medication-induced crystalluria has a distinct phenotypic appearance. For instance, Sulphadiazine crystals appear as strongly birefringent 'shocks of wheat' or 'shells' with an amber color. Acyclovir crystals are birefringent and needle-shaped, and when present in abundance give to urine a silky and opalescent macroscopic appearance.
http://purl.obolibrary.org/obo/HP_0033069	Renal interstitial IgG4+ plasma cell infiltration	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		An increased number of IgG4+ plasma cells in the interstitial space of the kidney.
http://purl.obolibrary.org/obo/HP_0033070	Impaired self monitoring	http://purl.obolibrary.org/obo/HP_0033051	Impaired executive functioning		Impaired ability to track awareness of the effect that one's behavior has on others and how it compares with standards or expectations for behavior.
http://purl.obolibrary.org/obo/HP_0033071	Impaired task monitoring	http://purl.obolibrary.org/obo/HP_0033051	Impaired executive functioning		Impaired ability to keep track of one's problem-solving success or failure, and to identify and correct mistakes during performance of a goal.
http://purl.obolibrary.org/obo/HP_0033073	Urate tophus	http://purl.obolibrary.org/obo/HP_0011356	Regional abnormality of skin		Intradermal urate crystal deposits appeared as small, superficial, pustule-like, whitish lesions. The lesions may be the focus of inflammatory episodes with increasing pain, swelling, and erythema of the intradermal tophi.
http://purl.obolibrary.org/obo/HP_0033074	Steroid-responsive anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		Amelioration of anemia upon treatment with a steroid medication.
http://purl.obolibrary.org/obo/HP_0033075	Inappropriately normal thyroid-stimulating hormone level	http://purl.obolibrary.org/obo/HP_0031097	Abnormal circulating thyroid-stimulating hormone concentration		A normal or elevated serum thyroid-stimulating hormone (TSH) level in the face of an elevation in circulating FT4 and/or FT3.
http://purl.obolibrary.org/obo/HP_0033076	Abnormal circulating free T4 concentration	http://purl.obolibrary.org/obo/HP_0031508	Abnormal circulating thyroid hormone concentration		A deviation from the normal concentration of free thyroxine (T4) in the blood circulation. Circulating T4 is almost entirely bound to specific transport proteins such as thyroxine-binding globulin (TBG) but it is the unbound (free) fraction that is able to enter tissues and exert effects.
http://purl.obolibrary.org/obo/HP_0033077	Increased circulating free T4 concentration	http://purl.obolibrary.org/obo/HP_0033076	Abnormal circulating free T4 concentration		An elevated concentration of free thyroxine (fT4) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033078	Decreased circulating free T4 concentration	http://purl.obolibrary.org/obo/HP_0033076	Abnormal circulating free T4 concentration		A reduced concentration of free thyroxine (fT4) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033080	Abnormal TSH response to thyrotrophin-releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide synthesized by, stored within, and released from the hypothalamus. It stimulates the synthesis and release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. Following administration of exogenous TRH, a transient increase in serum TSH is expected. This term refers to an abnormal response in the TRH stimulation test.
http://purl.obolibrary.org/obo/HP_0033081	Absent TSH response to thyrotrophin-releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0033080	Abnormal TSH response to thyrotrophin-releasing hormone stimulation test		Failure to increase serum TSH levels in response to a TRH stimulation test.
http://purl.obolibrary.org/obo/HP_0033082	Reduced TSH response to thyrotrophin-releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0033080	Abnormal TSH response to thyrotrophin-releasing hormone stimulation test		A lower than normal TSH response to thyrotrophin-releasing hormone stimulation test.
http://purl.obolibrary.org/obo/HP_0033083	Increased circulating farnesol concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		An elevated level of farnesol in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033084	Abnormal antral follicle count	http://purl.obolibrary.org/obo/HP_0031066	Abnormal ovarian physiology		Any deviation from a count of antral follicles that is normal for age. Antral follicles appear as small fluid-filled sacs that contain an immature egg. Antral follicle count can be measured (usually on day 2-5 of the menstrual cycle) by transvaginal ultrasound. The number of antral follicles may reflect ovarian reserve.
http://purl.obolibrary.org/obo/HP_0033085	Reduced antral follicle count	http://purl.obolibrary.org/obo/HP_0033084	Abnormal antral follicle count		A count of antral follicles that is lower than normal for age.
http://purl.obolibrary.org/obo/HP_0033086	Increased antral follicle count	http://purl.obolibrary.org/obo/HP_0033084	Abnormal antral follicle count		A count of antral follicles that is higher than normal for age.
http://purl.obolibrary.org/obo/HP_0033087	Quotidian fever	http://purl.obolibrary.org/obo/HP_0032323	Periodic fever		Fever that occurs at daily intervals.
http://purl.obolibrary.org/obo/HP_0033088	Valinuria	http://purl.obolibrary.org/obo/HP_0033089	Branched-chain aminoaciduria		Urine valine level above the normal range.
http://purl.obolibrary.org/obo/HP_0041052	Agenesis of putamen	http://purl.obolibrary.org/obo/HP_0031982	Abnormal putamen morphology		A developmental defect characterized by the absence of the putamen owing to its failure to develop.
http://purl.obolibrary.org/obo/HP_0041055	Fractured humerus	http://purl.obolibrary.org/obo/HP_0041245	Fractured shoulder bone		A partial or complete breakage of the humerus.
http://purl.obolibrary.org/obo/HP_0041056	Hot cross bun sign	http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology		A cruciform-shaped hyperintensity within the pons found on T2-weighted magnetic resonance imaging (MRI).
http://purl.obolibrary.org/obo/HP_0041057	Transient decreased circulating IgG4 concentration	http://purl.obolibrary.org/obo/HP_0032138	Decreased circulating IgG4 concentration		A temporary reduction beneath the normal level of total immunoglobulin G4 (IgG4) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0041058	Chronic decreased circulating IgG4 concentration	http://purl.obolibrary.org/obo/HP_0032138	Decreased circulating IgG4 concentration		A lasting decrease of immunoglobulin G4 (IgG4) in the blood.
http://purl.obolibrary.org/obo/HP_0041059	Chronic absent circulating IgG4	http://purl.obolibrary.org/obo/HP_0032138	Decreased circulating IgG4 concentration		A lasting absence of immunoglobulin G4 (IgG4) in the blood, whereby at most trace quantities of IgG4 can be measured.
http://purl.obolibrary.org/obo/HP_0041061	Fractured calcaneus	http://purl.obolibrary.org/obo/HP_0041247	Fractured tarsal bone		A partial or complete breakage of the calcaneus.
http://purl.obolibrary.org/obo/HP_0041062	Transient decreased circulating IgG2 concentration	http://purl.obolibrary.org/obo/HP_0008348	Decreased circulating IgG2 concentration		A temporary reduction beneath the normal level of total immunoglobulin G2 (IgG2) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0041063	Chronic decreased circulating IgG2 concentration	http://purl.obolibrary.org/obo/HP_0008348	Decreased circulating IgG2 concentration		A lasting decrease of immunoglobulin G2 (IgG2) in the blood.
http://purl.obolibrary.org/obo/HP_0041065	Chronic absent circulating IgG2	http://purl.obolibrary.org/obo/HP_0008348	Decreased circulating IgG2 concentration		A lasting absence of immunoglobulin G2 (IgG2) in the blood, whereby at most trace quantities of IgG2 can be measured.
http://purl.obolibrary.org/obo/HP_0041067	Transient decreased circulating IgG1 concentration	http://purl.obolibrary.org/obo/HP_0032136	Decreased circulating IgG1 concentration		A temporary reduction beneath the normal level of total immunoglobulin G1 (IgG1) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0041068	Chronic decreased circulating IgG1 concentration	http://purl.obolibrary.org/obo/HP_0032136	Decreased circulating IgG1 concentration		A lasting decrease of immunoglobulin G1 (IgG1) in the blood.
http://purl.obolibrary.org/obo/HP_0041069	Chronic absent circulating IgG1	http://purl.obolibrary.org/obo/HP_0032136	Decreased circulating IgG1 concentration		A lasting absence of immunoglobulin G1 (IgG1) in the blood, whereby at most trace quantities of IgG1 can be measured.
http://purl.obolibrary.org/obo/HP_0041071	Transient decreased circulating IgG3 concentration	http://purl.obolibrary.org/obo/HP_0032137	Decreased circulating IgG3 concentration		A temporary reduction beneath the normal level of total immunoglobulin G3 (IgG3) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0041072	Chronic decreased circulating IgG3 concentration	http://purl.obolibrary.org/obo/HP_0032137	Decreased circulating IgG3 concentration		A lasting decrease of immunoglobulin G3 (IgG3) in the blood.
http://purl.obolibrary.org/obo/HP_0041073	Fractured thoracic vertebra	http://purl.obolibrary.org/obo/HP_0041166	Fractured vertebra		A partial or complete breakage of the thoracic vertebra.
http://purl.obolibrary.org/obo/HP_0041074	Chronic absent circulating IgG3	http://purl.obolibrary.org/obo/HP_0032137	Decreased circulating IgG3 concentration		A lasting absence of immunoglobulin G3 (IgG3) in the blood, whereby at most trace quantities of IgG3 can be measured.
http://purl.obolibrary.org/obo/HP_0041076	Abnormal immunoglobulin level in body fluid	http://purl.obolibrary.org/obo/HP_0005372	Abnormal B cell physiology		An abnormal deviation from normal levels of immunoglobulins in body fluids, such as mucous.
http://purl.obolibrary.org/obo/HP_0041077	Increased immunoglobulin level in body fluid	http://purl.obolibrary.org/obo/HP_0041076	Abnormal immunoglobulin level in body fluid		An elevation from normal levels of immunoglobulins in body fluids, such as mucous.
http://purl.obolibrary.org/obo/HP_0041079	Decreased body fat percentage	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		The percentage of fat as a part of total body weight below the norm, usually defined as less than 14% for females and less than 8% for males.
http://purl.obolibrary.org/obo/HP_0041080	Abnormal exhausted T cell proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		A deviation from the normal proportion of exhausted T cell relative to T cell in the blood.
http://purl.obolibrary.org/obo/HP_0041081	Fractured lower leg	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		Bone fracture anywhere in the tibia, fibula, or ankle.
http://purl.obolibrary.org/obo/HP_0041082	Fractured skull	http://purl.obolibrary.org/obo/HP_0000929	Abnormal skull morphology		A partial or complete breakage of the skull.
http://purl.obolibrary.org/obo/HP_0041083	Fractured phalanx	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the phalanx.
http://purl.obolibrary.org/obo/HP_0041084	Compression-fractured thoracic vertebra	http://purl.obolibrary.org/obo/HP_0041073	Fractured thoracic vertebra		A fracture of the thoracic vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.
http://purl.obolibrary.org/obo/HP_0041085	Compression-fractured vertebra	http://purl.obolibrary.org/obo/HP_0041166	Fractured vertebra		A fracture of the vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.
http://purl.obolibrary.org/obo/HP_0041086	Compression-fractured cervical vertebra	http://purl.obolibrary.org/obo/HP_0041167	Fractured cervical vertebra		A fracture of the cervical vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.
http://purl.obolibrary.org/obo/HP_0041087	Compression-fractured lumbar vertebra	http://purl.obolibrary.org/obo/HP_0041168	Fractured lumbar vertebra		A fracture of the lumbar vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.
http://purl.obolibrary.org/obo/HP_0041088	Avulsion fractured humerus	http://purl.obolibrary.org/obo/HP_0041055	Fractured humerus		A fractured in which a fragment of the humerus tears away from the main mass of bone as a result of physical trauma.
http://purl.obolibrary.org/obo/HP_0041089	Avulsion fractured tibia	http://purl.obolibrary.org/obo/HP_0041143	Fractured tibia		A fractured in which a fragment of the tibia tears away from the main mass of bone as a result of physical trauma.
http://purl.obolibrary.org/obo/HP_0041090	Pelvic avulsion fracture	http://purl.obolibrary.org/obo/HP_0041161	Pelvis fracture		An avulsion fracture (i.e., a type of fracture in which a piece of bone tears away from the site where the muscle attaches to the bone) of a bone of the pelvis.
http://purl.obolibrary.org/obo/HP_0041091	Avulsion fractured epiphysis of femur	http://purl.obolibrary.org/obo/HP_0041189	Fractured epiphysis of femur		A fractured in which the fragment of the epiphysis of femur bone tears away from the main mass of bone as a result of physical trauma.
http://purl.obolibrary.org/obo/HP_0041092	Emotional hypersensitivity	http://purl.obolibrary.org/obo/HP_0020007	Abnormal affect regulation		Heightened emotional reactivity or response to environmental stimuli, including the emotions of others that include behaviors or expressive outbursts that are beyond the accepted cultural range and norms.
http://purl.obolibrary.org/obo/HP_0041114	Fractured metaphysis of femur	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the metaphysis of femur.
http://purl.obolibrary.org/obo/HP_0041115	Fractured right clavicle	http://purl.obolibrary.org/obo/HP_0041144	Fractured clavicle bone		A partial or complete breakage of the right clavicle.
http://purl.obolibrary.org/obo/HP_0041116	Fractured left clavicle	http://purl.obolibrary.org/obo/HP_0041144	Fractured clavicle bone		A partial or complete breakage of the left clavicle.
http://purl.obolibrary.org/obo/HP_0041117	Fractured lower limb segment	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		A partial or complete breakage of the lower limb segment.
http://purl.obolibrary.org/obo/HP_0041118	Fractured upper limb segment	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		A partial or complete breakage of the upper limb segment.
http://purl.obolibrary.org/obo/HP_0041119	Fractured metacarpus skeleton	http://purl.obolibrary.org/obo/HP_0004277	Fractured hand bones		A partial or complete breakage of the metacarpus skeleton.
http://purl.obolibrary.org/obo/HP_0041121	Fractured epiphysis of fifth metacarpal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of fifth metacarpal bone.
http://purl.obolibrary.org/obo/HP_0041143	Fractured tibia	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the tibia.
http://purl.obolibrary.org/obo/HP_0041144	Fractured clavicle bone	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the clavicle bone.
http://purl.obolibrary.org/obo/HP_0041145	Fractured acetabular part of hip bone	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the acetabular part of hip bone.
http://purl.obolibrary.org/obo/HP_0041146	Fractured coccyx	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the coccyx.
http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the epiphysis.
http://purl.obolibrary.org/obo/HP_0041149	Fractured navicular bone of pes	http://purl.obolibrary.org/obo/HP_0041247	Fractured tarsal bone		A partial or complete breakage of the navicular bone of pes.
http://purl.obolibrary.org/obo/HP_0041150	Fractured cuboid bone	http://purl.obolibrary.org/obo/HP_0041226	Fractured distal tarsal bone		A partial or complete breakage of the cuboid bone.
http://purl.obolibrary.org/obo/HP_0041152	Fractured sternoclavicular joint	http://purl.obolibrary.org/obo/HP_0009810	Abnormality of upper limb joint		A partial or complete breakage of the sternoclavicular joint.
http://purl.obolibrary.org/obo/HP_0041153	Fractured ankle	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		A fracture or multiple fractures of one or more of three bones in the ankle joint: the tibia (shinbone), the fibula (outer ankle bone), and the talus (which is the bone that connects your leg to your foot).
http://purl.obolibrary.org/obo/HP_0041155	Fractured mandible	http://purl.obolibrary.org/obo/HP_0041234	Fractured bone of jaw		A partial or complete breakage of the mandible.
http://purl.obolibrary.org/obo/HP_0041156	Fractured orbit of skull	http://purl.obolibrary.org/obo/HP_3000030	Abnormal morphology of bony orbit of skull		A partial or complete breakage of the orbit of skull.
http://purl.obolibrary.org/obo/HP_0041157	Fractured larynx	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		A partial or complete breakage of the larynx.
http://purl.obolibrary.org/obo/HP_0041159	Fractured rib	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the rib.
http://purl.obolibrary.org/obo/HP_0041161	Pelvis fracture	http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology		A break in one or more bones of the pelvis.
http://purl.obolibrary.org/obo/HP_0041162	Metatarsal fracture	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of a metatarsal bone.
http://purl.obolibrary.org/obo/HP_0041163	Fractured manual digit	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		A partial or complete breakage of the manual digit.
http://purl.obolibrary.org/obo/HP_0041164	Fractured talus	http://purl.obolibrary.org/obo/HP_0041247	Fractured tarsal bone		A partial or complete breakage of the talus.
http://purl.obolibrary.org/obo/HP_0041165	Fractured maxilla	http://purl.obolibrary.org/obo/HP_0041234	Fractured bone of jaw		A partial or complete breakage of the maxilla.
http://purl.obolibrary.org/obo/HP_0041166	Fractured vertebra	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the vertebra.
http://purl.obolibrary.org/obo/HP_0041167	Fractured cervical vertebra	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		A partial or complete breakage of the cervical vertebra.
http://purl.obolibrary.org/obo/HP_0041168	Fractured lumbar vertebra	http://purl.obolibrary.org/obo/HP_0041166	Fractured vertebra		A partial or complete breakage of the lumbar vertebra.
http://purl.obolibrary.org/obo/HP_0041172	Fractured fused sacrum	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the fused sacrum.
http://purl.obolibrary.org/obo/HP_0041173	Fractured metacarpophalangeal joint	http://purl.obolibrary.org/obo/HP_0011911	Abnormal metacarpophalangeal joint morphology		A partial or complete breakage of the metacarpophalangeal joint.
http://purl.obolibrary.org/obo/HP_0041174	Fractured distal finger phalanx	http://purl.obolibrary.org/obo/HP_0041241	Fractured finger phalanx		A partial or complete breakage of the distal phalanx of manus.
http://purl.obolibrary.org/obo/HP_0041175	Fractured middle phalanx of pes	http://purl.obolibrary.org/obo/HP_0041240	Toe phalanx fracture		A partial or complete breakage of the middle phalanx of pes.
http://purl.obolibrary.org/obo/HP_0041176	Fractured distal phalanx of manual digit 2	http://purl.obolibrary.org/obo/HP_0041174	Fractured distal finger phalanx		A partial or complete breakage of the distal phalanx of manual digit 2.
http://purl.obolibrary.org/obo/HP_0041177	Fractured distal phalanx of manual digit 3	http://purl.obolibrary.org/obo/HP_0041174	Fractured distal finger phalanx		A partial or complete breakage of the distal phalanx of manual digit 3.
http://purl.obolibrary.org/obo/HP_0041178	Fractured distal phalanx of manual digit 4	http://purl.obolibrary.org/obo/HP_0041174	Fractured distal finger phalanx		A partial or complete breakage of the distal phalanx of manual digit 4.
http://purl.obolibrary.org/obo/HP_0041179	Fractured distal phalanx of manual digit 5	http://purl.obolibrary.org/obo/HP_0041174	Fractured distal finger phalanx		A partial or complete breakage of the distal phalanx of manual digit 5.
http://purl.obolibrary.org/obo/HP_0041180	Fractured distal phalanx of pedal digit 1	http://purl.obolibrary.org/obo/HP_0041240	Toe phalanx fracture		A partial or complete breakage of the distal phalanx of pedal digit 1.
http://purl.obolibrary.org/obo/HP_0041181	Fractured distal phalanx of pedal digit 3	http://purl.obolibrary.org/obo/HP_0041240	Toe phalanx fracture		A partial or complete breakage of the distal phalanx of pedal digit 3.
http://purl.obolibrary.org/obo/HP_0041182	Fractured middle phalanx of manual digit 2	http://purl.obolibrary.org/obo/HP_0041236	Fractured middle phalanx of finger		A partial or complete breakage of the middle phalanx of manual digit 2.
http://purl.obolibrary.org/obo/HP_0041183	Fractured middle phalanx of manual digit 3	http://purl.obolibrary.org/obo/HP_0041236	Fractured middle phalanx of finger		A partial or complete breakage of the middle phalanx of manual digit 3.
http://purl.obolibrary.org/obo/HP_0041184	Fractured middle phalanx of manual digit 4	http://purl.obolibrary.org/obo/HP_0041236	Fractured middle phalanx of finger		A partial or complete breakage of the middle phalanx of manual digit 4.
http://purl.obolibrary.org/obo/HP_0041185	Fractured middle phalanx of manual digit 5	http://purl.obolibrary.org/obo/HP_0041236	Fractured middle phalanx of finger		A partial or complete breakage of the middle phalanx of manual digit 5.
http://purl.obolibrary.org/obo/HP_0041186	Fractured middle phalanx of pedal digit 3	http://purl.obolibrary.org/obo/HP_0041175	Fractured middle phalanx of pes		A partial or complete breakage of the middle phalanx of pedal digit 3.
http://purl.obolibrary.org/obo/HP_0041187	Fractured proximal phalanx of pedal digit 1	http://purl.obolibrary.org/obo/HP_0041240	Toe phalanx fracture		A partial or complete breakage of the proximal phalanx of pedal digit 1.
http://purl.obolibrary.org/obo/HP_0041188	Fractured proximal phalanx of manual digit 1	http://purl.obolibrary.org/obo/HP_0041243	Fractured proximal phalanx of finger		A partial or complete breakage of the proximal phalanx of manual digit 1.
http://purl.obolibrary.org/obo/HP_0041189	Fractured epiphysis of femur	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of femur.
http://purl.obolibrary.org/obo/HP_0041190	Fractured epiphysis of second metacarpal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of second metacarpal bone.
http://purl.obolibrary.org/obo/HP_0041191	Fractured epiphysis of third metacarpal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of third metacarpal bone.
http://purl.obolibrary.org/obo/HP_0041192	Fractured epiphysis of fourth metacarpal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of fourth metacarpal bone.
http://purl.obolibrary.org/obo/HP_0041193	Fractured epiphysis of first metatarsal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of first metatarsal bone.
http://purl.obolibrary.org/obo/HP_0041194	Fractured epiphysis of second metatarsal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of second metatarsal bone.
http://purl.obolibrary.org/obo/HP_0041195	Fractured epiphysis of third metatarsal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of third metatarsal bone.
http://purl.obolibrary.org/obo/HP_0041196	Fractured distal epiphysis of radius	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the distal epiphysis of radius.
http://purl.obolibrary.org/obo/HP_0041197	Fractured proximal epiphysis of first metacarpal bone	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the proximal epiphysis of first metacarpal bone.
http://purl.obolibrary.org/obo/HP_0041198	Fractured proximal epiphysis of middle phalanx of manual digit 3	http://purl.obolibrary.org/obo/HP_0041209	Fractured epiphysis of middle phalanx of manus		A partial or complete breakage of the proximal epiphysis of middle phalanx of manual digit 3.
http://purl.obolibrary.org/obo/HP_0041199	Fractured interphalangeal joint	http://purl.obolibrary.org/obo/HP_0011297	Abnormal digit morphology		A partial or complete breakage of the interphalangeal joint.
http://purl.obolibrary.org/obo/HP_0041200	Fractured sternal end of clavicle	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the sternal end of clavicle.
http://purl.obolibrary.org/obo/HP_0041209	Fractured epiphysis of middle phalanx of manus	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the epiphysis of middle phalanx of manus.
http://purl.obolibrary.org/obo/HP_0041210	Fractured lateral malleolus of fibula	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the lateral malleolus of fibula.
http://purl.obolibrary.org/obo/HP_0041211	Fractured proximal phalanx of digit 2	http://purl.obolibrary.org/obo/HP_0041083	Fractured phalanx		A partial or complete breakage of the proximal phalanx of digit 2.
http://purl.obolibrary.org/obo/HP_0041212	Fractured proximal phalanx of digit 3	http://purl.obolibrary.org/obo/HP_0041083	Fractured phalanx		A partial or complete breakage of the proximal phalanx of digit 3.
http://purl.obolibrary.org/obo/HP_0041213	Fractured proximal phalanx of digit 4	http://purl.obolibrary.org/obo/HP_0041083	Fractured phalanx		A partial or complete breakage of the proximal phalanx of digit 4.
http://purl.obolibrary.org/obo/HP_0041214	Fractured proximal phalanx of digit 5	http://purl.obolibrary.org/obo/HP_0041083	Fractured phalanx		A partial or complete breakage of the proximal phalanx of digit 5.
http://purl.obolibrary.org/obo/HP_0041215	Fractured fused metatarsal bones 2-4	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the fused metatarsal bones 2-4.
http://purl.obolibrary.org/obo/HP_0041216	Fractured distal epiphysis of distal phalanx of manual digit 1	http://purl.obolibrary.org/obo/HP_0041147	Fractured epiphysis		A partial or complete breakage of the distal epiphysis of distal phalanx of manual digit 1.
http://purl.obolibrary.org/obo/HP_0041217	Fractured shoulder	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A fracture or multiple fractures of the humerus (ball) or the glenoid (socket) of the shoulder joint.
http://purl.obolibrary.org/obo/HP_0041218	Fractured distal phalanx	http://purl.obolibrary.org/obo/HP_0041083	Fractured phalanx		A partial or complete breakage of the distal phalanx.
http://purl.obolibrary.org/obo/HP_0041219	Elbow fracture	http://purl.obolibrary.org/obo/HP_0041118	Fractured upper limb segment		A partial or complete breakage of the elbow.
http://purl.obolibrary.org/obo/HP_0041220	Fractured facial bone	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the facial bone.
http://purl.obolibrary.org/obo/HP_0041221	Fractured head of femur	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the head of femur.
http://purl.obolibrary.org/obo/HP_0041222	Fractured fibula	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the fibula.
http://purl.obolibrary.org/obo/HP_0041223	Fractured metatarsal bone of digit 5	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the metatarsal bone of digit 5.
http://purl.obolibrary.org/obo/HP_0041224	Fractured manual digit bone	http://purl.obolibrary.org/obo/HP_0040070	Abnormal upper limb bone morphology		A partial or complete breakage of the manual digit bone.
http://purl.obolibrary.org/obo/HP_0041225	Fractured 1st metacarpal	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A partial or complete breakage of the metacarpal bone of digit 1.
http://purl.obolibrary.org/obo/HP_0041226	Fractured distal tarsal bone	http://purl.obolibrary.org/obo/HP_0041247	Fractured tarsal bone		A partial or complete breakage of the distal tarsal bone.
http://purl.obolibrary.org/obo/HP_0041227	Fractured distal tarsal bone 2	http://purl.obolibrary.org/obo/HP_0041226	Fractured distal tarsal bone		A partial or complete breakage of the distal tarsal bone 2.
http://purl.obolibrary.org/obo/HP_0041228	Fractured distal tarsal bone 3	http://purl.obolibrary.org/obo/HP_0041226	Fractured distal tarsal bone		A partial or complete breakage of the distal tarsal bone 3.
http://purl.obolibrary.org/obo/HP_0041230	Fractured metatarsal bone of digit 4	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the metatarsal bone of digit 4.
http://purl.obolibrary.org/obo/HP_0041231	Fractured metatarsal bone of digit 1	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the metatarsal bone of digit 1.
http://purl.obolibrary.org/obo/HP_0041233	Fractured ilium	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the ilium.
http://purl.obolibrary.org/obo/HP_0041234	Fractured bone of jaw	http://purl.obolibrary.org/obo/HP_0041220	Fractured facial bone		A partial or complete breakage of the bone of jaw.
http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the hindlimb bone.
http://purl.obolibrary.org/obo/HP_0041236	Fractured middle phalanx of finger	http://purl.obolibrary.org/obo/HP_0041241	Fractured finger phalanx		A partial or complete breakage of the middle phalanx of a finger.
http://purl.obolibrary.org/obo/HP_0041237	Fractured patella	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the patella.
http://purl.obolibrary.org/obo/HP_0041239	Fractured thumb phalanx	http://purl.obolibrary.org/obo/HP_0041241	Fractured finger phalanx		A partial or complete breakage of a phalanx of the thumb.
http://purl.obolibrary.org/obo/HP_0041240	Toe phalanx fracture	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the phalanx of pes.
http://purl.obolibrary.org/obo/HP_0041241	Fractured finger phalanx	http://purl.obolibrary.org/obo/HP_0041224	Fractured manual digit bone		A partial or complete breakage of the phalanx of a finger.
http://purl.obolibrary.org/obo/HP_0041243	Fractured proximal phalanx of finger	http://purl.obolibrary.org/obo/HP_0041241	Fractured finger phalanx		A partial or complete breakage of the proximal phalanx of manus.
http://purl.obolibrary.org/obo/HP_0041244	Fractured scapula	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of the scapula.
http://purl.obolibrary.org/obo/HP_0041245	Fractured shoulder bone	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		A partial or complete breakage of a shoulder bone.
http://purl.obolibrary.org/obo/HP_0041246	Fractured sternum	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		A partial or complete breakage of the sternum.
http://purl.obolibrary.org/obo/HP_0041247	Fractured tarsal bone	http://purl.obolibrary.org/obo/HP_0041235	Fractured hindlimb bone		A partial or complete breakage of the tarsal bone.
http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone	http://purl.obolibrary.org/obo/HP_0004277	Fractured hand bones		A partial or complete breakage of the carpal bone.
http://purl.obolibrary.org/obo/HP_0041249	Fractured nose	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		A partial or complete breakage of the nose.
http://purl.obolibrary.org/obo/PR_000050097	creatine kinase (human)	http://purl.obolibrary.org/obo/PR_000029067	Homo sapiens protein		A creatine kinase that is encoded in the genome of human.
http://purl.obolibrary.org/obo/HP_0033090	Increased aromatic amino acid level in urine	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An elevated level of an aromatic amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0033093	Increased glutamine family amino acid level in urine	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An elevated level of an glutamine family amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0033095	Increased sulfur amino acid level in urine	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An elevated level of a sulfur-containing amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0033096	Increased aspartate family amino acid level in urine	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An elevated level of an aspartate family amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level	http://purl.obolibrary.org/obo/HP_0003355	Aminoaciduria		An elevated urine level of a compound that is derived from an amino acid.
http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level	http://purl.obolibrary.org/obo/HP_0003355	Aminoaciduria		An increased level in the urine of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
http://purl.obolibrary.org/obo/HP_0033099	Increased serine family amino acid in urine	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An increased level of a serine family amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine	http://purl.obolibrary.org/obo/HP_0003355	Aminoaciduria		An elevated level of a proteinogenic amino acid in the urine. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine.
http://purl.obolibrary.org/obo/HP_0033107	Abnormal circulating proteinogenic amino acid concentration	http://purl.obolibrary.org/obo/HP_0003112	Abnormal circulating amino acid concentration		Any deviation from the normal concentration of proteinogenic amino acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration	http://purl.obolibrary.org/obo/HP_0003112	Abnormal circulating amino acid concentration		Any deviation from the normal concentration of proteinogenic amino acid derivative in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function	http://purl.obolibrary.org/obo/HP_0030872	Abnormal cardiac ventricular function		Anomalous physiology (function) of the right ventricle.
http://purl.obolibrary.org/obo/HP_0033127	Abnormality of the musculoskeletal system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		An anomaly of the musculoskeletal system, which consists of the bones of the skeleton, muscles, cartilage, tendons, ligaments, joints, and other connective tissue. The musculoskeletal system supports the weight of the body, maintains body position and produces movements of the body or of parts of the body.
http://purl.obolibrary.org/obo/HP_0033130	Abnormal renal echogenicity	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Anomalous echogenicity of the kidney on ultrasound examination.
http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology	http://purl.obolibrary.org/obo/HP_0000600	Abnormality of the pharynx		A structural anomaly of the pharynx.
http://purl.obolibrary.org/obo/CHEBI_167114	2-hydroxydicarboxylate(2-)	http://purl.obolibrary.org/obo/CHEBI_35693	dicarboxylic acid anion		Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group. Major species at pH 7.3.
http://purl.obolibrary.org/obo/CL_0009057	anorectum goblet cell	http://purl.obolibrary.org/obo/CL_1000320	large intestine goblet cell		A goblet cell that is located in the anorectum.
http://purl.obolibrary.org/obo/CL_0009063	enteroendocrine cell of anorectum	http://purl.obolibrary.org/obo/CL_1001516	intestinal enteroendocrine cell		An enteroendocrine cell that is located in the anorectum.
http://purl.obolibrary.org/obo/UBERON_8440004	laminar subdivision of the cortex	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		One or a subset of adjacent layers of the neocortex.
http://purl.obolibrary.org/obo/UBERON_7500065	condyle of talus	http://purl.obolibrary.org/obo/UBERON_0009979	condyle		An articular prominence of a talus that engages with the tibia.
http://purl.obolibrary.org/obo/UBERON_7500078	styloid process of radius	http://purl.obolibrary.org/obo/UBERON_0009979	condyle		A condyle on the distal end and lateral side of a radius.
http://purl.obolibrary.org/obo/UBERON_7500094	tubercle of calcaneus	http://purl.obolibrary.org/obo/UBERON_4100000	skeletal element projection		A raised projection on the calcaneus.
http://purl.obolibrary.org/obo/CL_4028001	pulmonary capillary endothelial cell	http://purl.obolibrary.org/obo/CL_2000016	lung microvascular endothelial cell		Any capillary endothelial cell that is part of a lung.
http://purl.obolibrary.org/obo/HP_0025669	Abnormal neck physiology	http://purl.obolibrary.org/obo/HP_0000464	Abnormality of the neck		Any functional anomaly of the neck region.
http://purl.obolibrary.org/obo/HP_0025723	Abnormal fetal skin morphology	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		Any structural anomaly of the skin of the fetus or newborn. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0034200	Abnormal CSF homovanillic acid concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Any deviation from the normal concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine.
http://purl.obolibrary.org/obo/HP_0034237	Open neural tube defect	http://purl.obolibrary.org/obo/HP_0045005	Neural tube defect		A type of neural tube defect that is not covered by skin.
http://purl.obolibrary.org/obo/HP_0034238	Closed neural tube defect	http://purl.obolibrary.org/obo/HP_0045005	Neural tube defect		A type of neural tube defect that is covered by skin.
http://purl.obolibrary.org/obo/HP_0041095	Decreased middle cerebral artery pulsatility index	http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology		Abnormally reduced blood flow pulsatility in in the middle cerebral artery (MCA). The pulsatility index (PI) is calculated using the following equation PI = (peak systolic velocity-end-diastolic velocity)/mean velocity.
http://purl.obolibrary.org/obo/HP_4000072	Abnormal language feature	http://purl.obolibrary.org/obo/HP_0034434	Abnormal communication		The presence of any atypical form of expressive language.
http://purl.obolibrary.org/obo/HP_4000073	Pronoun reversal	http://purl.obolibrary.org/obo/HP_4000072	Abnormal language feature		Atypical language features characterized by first vs. second or third person pronoun errors such as using 'you' or 'he/she' in place of 'I'.
http://purl.obolibrary.org/obo/HP_4000074	Involuntary vocalization	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		Production of sound done without will or conscious control. Involuntary vocalizations include tics, stereotypies vocalizations as part of dystonia or chorea, continuous vocalizing behaviors such as groaning or grunting, pathological laughter and crying, and others. These vocalizations are not recognized as socially or culturally appropriate.
http://purl.obolibrary.org/obo/HP_4000075	Reduced frequency of facial expressions	http://purl.obolibrary.org/obo/HP_4000087	Abnormal communicative facial expressions		The number of times facial expressions are produced in a given period is lower than expected given the social and cultural context.
http://purl.obolibrary.org/obo/HP_4000076	Use of another person's body to communicate	http://purl.obolibrary.org/obo/HP_0000758	Abnormal nonverbal communicative behavior		Moving another person's hand, body part, or body to communicate a desire, e.g. pushing or pulling someone toward a desired object or placing someone's hand on something.
http://purl.obolibrary.org/obo/HP_4000077	Fixated interest with abnormal focus	http://purl.obolibrary.org/obo/HP_4000070	Fixated interests		A fixated interest in a specific topic that is atypical for the social context of the individual, such as topics of a non-social nature like fossils or vacuum cleaners.
http://purl.obolibrary.org/obo/HP_4000078	Fixated interest with abnormal intensity	http://purl.obolibrary.org/obo/HP_4000070	Fixated interests		An abnormally intense interest in a topic or object that is not atypical for the social context of the affected person.
http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking	http://purl.obolibrary.org/obo/HP_5200046	Sensory behavioral abnormality		Unusual interest in sensory aspects of the environment.
http://purl.obolibrary.org/obo/HP_4000081	Reduced production of gestures	http://purl.obolibrary.org/obo/HP_4000090	Abnormal gesture use		Diminished use of typical non-verbal conversational gestures such as shaking the head to indicate no or nodding the head to indicate yes.
http://purl.obolibrary.org/obo/HP_4000082	Reduced cooperative play	http://purl.obolibrary.org/obo/HP_5200104	Abnormal play		Impairment in a child's ability to be able to play in a way that involves peer collaboration. Collaborative play involves things such as verbal and non-verbal communication (e.g., self-initiated interactions), turn-taking, sharing, reciprocity, and collaborative problem-solving. It is often contrasted to parallel play, which involves a form of social play in which two children do similar activities near each other and often mimic each other. Typically developing children develop collaborative play between the ages of 4 and 5.
http://purl.obolibrary.org/obo/HP_4000083	Lack of interest in peers	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		Lack of interest in peers of comparable age and social groups is evident when an individual, such as a child, shows more interest in socializing with adults rather than children their own age.
http://purl.obolibrary.org/obo/HP_4000084	Reduced sharing of interests	http://purl.obolibrary.org/obo/HP_5200027	Infrequent social initiations		An absence or abnormally low frequency of engaging with others to share personal interests or topics. Interest sharing includes offers of information about oneself as a form of social interaction.
http://purl.obolibrary.org/obo/HP_4000085	Reduced object sharing	http://purl.obolibrary.org/obo/HP_5200027	Infrequent social initiations		An absence or reduction in object sharing. Object sharing is an early emerging social skill in which a child will share objects such as toys, balls, or books with parents or peers during object play.
http://purl.obolibrary.org/obo/CL_4023072	brain vascular cell	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A cell that is part of the brain vasculature.
http://purl.obolibrary.org/obo/UBERON_8600018	neuroendocrine system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		A regulatory system of the body that integrates the nervous system and the endocrine system. This system is formed by specialized neuroendocrine cells located mainly in the nervous system and neuroendocrine glands. However, they can also be found as either single cells or small clusters of cells dispersed throughout the surface epithelium of different tissues. The neuroendocrine system functions through the release of neurotransmitters and neurohormones, enabling communication between the endocrine and nervous systems to govern vitally important processes that include growth, reproduction, metabolism and energy homeostasis, electrolyte and water balance, and responses to stress.
http://purl.obolibrary.org/obo/HP_6000692	Abnormal circulating proANP concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of proANP (atrial natriuretic peptide pro-hormone) in the blood circulation.
http://purl.obolibrary.org/obo/CL_4042003	border associated macrophage	http://purl.obolibrary.org/obo/CL_0000878	central nervous system macrophage		A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier.
http://purl.obolibrary.org/obo/HP_0025731	Anti-glycosylphosphatidylinositol anchored high-density lipoprotein binding protein 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glycosylphosphatidylinositol anchored high-density lipoprotein binding protein 1.
http://purl.obolibrary.org/obo/HP_0025733	Streak gonad	http://purl.obolibrary.org/obo/HP_0000133	Gonadal dysgenesis		A type of gonadal dysgenesis in which the gonadal tissue is underdeveloped and appears as fibrous, streak-like structures instead of fully formed ovaries or testes.
http://purl.obolibrary.org/obo/HP_0025734	Elevated urinary 5-hydroxyhexanoic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of 5-hydroxyhexanoic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/CL_0008041	mesothelial cell of intestine	http://purl.obolibrary.org/obo/CL_0000077	mesothelial cell		A mesothelial cell that is part of the intestinal serosa.
http://purl.obolibrary.org/obo/UBERON_0035036	naris epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		An epithelium that is part of a naris [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0035118	material entity in digestive tract	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included.
http://purl.obolibrary.org/obo/UBERON_0035814	pericardial fat	http://purl.obolibrary.org/obo/UBERON_0035818	visceral fat		The sum of epicardial and paracardial fat deposits.
http://purl.obolibrary.org/obo/UBERON_0035818	visceral fat	http://purl.obolibrary.org/obo/UBERON_0001013	adipose tissue		Any fat deposit surrounding a visceral organ.
http://purl.obolibrary.org/obo/UBERON_0036146	cardiopharyngeal field	http://purl.obolibrary.org/obo/UBERON_0007688	anlage		An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles.
http://purl.obolibrary.org/obo/UBERON_0036150	skin appendage follicle	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		An organ subunit in the skin that gives rise to cutaneous appendage.
http://purl.obolibrary.org/obo/UBERON_0034947	gas in respiratory system	http://purl.obolibrary.org/obo/UBERON_0034873	bodily gas		Any portion of gas located in a part of the respiratory system.
http://purl.obolibrary.org/obo/UBERON_0035159	entire surface of organism	http://purl.obolibrary.org/obo/UBERON_0006984	anatomical surface		Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface.
http://purl.obolibrary.org/obo/UBERON_0035174	right ear	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The organ of hearing located on the right side of the head.
http://purl.obolibrary.org/obo/UBERON_0035295	left ear	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		The organ of hearing located on the left side of the head[ncit,modified].
http://purl.obolibrary.org/obo/GO_0120031	plasma membrane bounded cell projection assembly	http://purl.obolibrary.org/obo/GO_0030031	cell projection assembly		Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.
http://purl.obolibrary.org/obo/GO_0120035	regulation of plasma membrane bounded cell projection organization	http://purl.obolibrary.org/obo/GO_0031344	regulation of cell projection organization		Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.
http://purl.obolibrary.org/obo/GO_0106014	regulation of inflammatory response to wounding	http://purl.obolibrary.org/obo/GO_0050727	regulation of inflammatory response		Any process that modulates the frequency, rate or extent of the inflammatory response to wounding.
http://purl.obolibrary.org/obo/GO_0106015	negative regulation of inflammatory response to wounding	http://purl.obolibrary.org/obo/GO_0106014	regulation of inflammatory response to wounding		Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding.
http://purl.obolibrary.org/obo/GO_0106016	positive regulation of inflammatory response to wounding	http://purl.obolibrary.org/obo/GO_0106014	regulation of inflammatory response to wounding		Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding.
http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology	http://purl.obolibrary.org/obo/HP_0000130	Abnormality of the uterus		Any anomaly of the structure of the uterus
http://purl.obolibrary.org/obo/GO_0099182	presynaptic intermediate filament cytoskeleton	http://purl.obolibrary.org/obo/GO_0099569	presynaptic cytoskeleton		The intermediate filament cytoskeleton that is part of a presynapse.
http://purl.obolibrary.org/obo/HP_0025562	Anterior chamber cells grade 0.5+	http://purl.obolibrary.org/obo/HP_0025560	Anterior chamber cells		Anterior chamber cells with 1-5 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.
http://purl.obolibrary.org/obo/HP_0025571	Christmas tree cataract	http://purl.obolibrary.org/obo/HP_0000518	Cataract		A type of cataract that shows a spectacular display of multiple colors that glitters with the change of incident light like an illuminated Christmas tree.
http://purl.obolibrary.org/obo/PATO_0045041	normal angle to	http://purl.obolibrary.org/obo/PATO_0045040	normal position		An angle which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045058	normal circumference	http://purl.obolibrary.org/obo/PATO_0045057	normal perimeter		A circumference which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045087	normal frequency	http://purl.obolibrary.org/obo/PATO_0045000	normal rate		A frequency which is relatively normal.
http://purl.obolibrary.org/obo/PATO_0045044	normal pressure	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A pressure which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045052	normal depth	http://purl.obolibrary.org/obo/PATO_0045050	normal size		A depth quality which is relatively normal or average
http://purl.obolibrary.org/obo/HP_0025587	Hyperdeviation	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		A type of strabismus in which the visual axis of one eye is higher than that of the other.
http://purl.obolibrary.org/obo/HP_0025575	Abnormal superior vena cava morphology	http://purl.obolibrary.org/obo/HP_0005345	Abnormal vena cava morphology		Any structural anomaly of the principal vein draining blood from the upper portion of the body and delivering it to the right ventricle of the heart.
http://purl.obolibrary.org/obo/HP_0025576	Abnormal inferior vena cava morphology	http://purl.obolibrary.org/obo/HP_0005345	Abnormal vena cava morphology		Any structural anomaly of the principal vein draining blood from the lower portion of the body.
http://purl.obolibrary.org/obo/HP_0025579	Abnormal left atrium morphology	http://purl.obolibrary.org/obo/HP_0005120	Abnormal cardiac atrium morphology		Any structural abnormality of the left atrium.
http://purl.obolibrary.org/obo/HP_0031651	Abnormal tricuspid valve physiology	http://purl.obolibrary.org/obo/HP_0031650	Abnormal atrioventricular valve physiology		Any functional defect of the tricuspid valve.
http://purl.obolibrary.org/obo/HP_0031690	Opportunistic infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system.
http://purl.obolibrary.org/obo/GO_0110096	cellular response to aldehyde	http://purl.obolibrary.org/obo/GO_1901701	cellular response to oxygen-containing compound		Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus.
http://purl.obolibrary.org/obo/CHEBI_139592	tertiary alpha-hydroxy ketone	http://purl.obolibrary.org/obo/CHEBI_139588	alpha-hydroxy ketone		An α-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups.
http://purl.obolibrary.org/obo/HP_0031806	Abnormal total basophil count	http://purl.obolibrary.org/obo/HP_0032309	Abnormal granulocyte count		Abnormal increase or decrease of absolute number of basophils in the blood, per microliter, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0031807	Increased total basophil count	http://purl.obolibrary.org/obo/HP_0031806	Abnormal total basophil count		Abnormal increase of absolute number of basophils in the blood, per microliter, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0031808	Decreased total basophil count	http://purl.obolibrary.org/obo/HP_0031806	Abnormal total basophil count		Abnormal decrease of absolute number of basophils in the blood, per microliter, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0031809	Archibald's sign	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		Shortening of the fourth and fifth metacarpals when the fist is clenched.
http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react to gangliosides.
http://purl.obolibrary.org/obo/HP_0031811	Bilirubinuria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Presence of conjugated bilirubin in the urine.
http://purl.obolibrary.org/obo/HP_0031812	Nitrituria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Presence of nitrites in the urine.
http://purl.obolibrary.org/obo/HP_0031813	Colonic eosinophilia	http://purl.obolibrary.org/obo/HP_0032064	Gastrointestinal eosinophilia		An excess of eosinophilic cells in colonic tissue, i.e., eosinophilic infiltration in the colon.
http://purl.obolibrary.org/obo/HP_0031814	Palilalia	http://purl.obolibrary.org/obo/HP_4000074	Involuntary vocalization		Palilalia is the involuntary repetition of one's own phrases, words, or syllables 2 or more times in a row. Typically, palilalic utterances decrease in volume with the increasing number of repetitions. Sometimes, the repetitions are also uttered with an accelerating speed.
http://purl.obolibrary.org/obo/HP_0031817	Decreased circulating parathyroid hormone level	http://purl.obolibrary.org/obo/HP_0100530	Abnormal circulating calcium-phosphate regulating hormone concentration		An abnormally decreased concentration of parathyroid hormone.
http://purl.obolibrary.org/obo/HP_0031818	Abnormal waist to hip ratio	http://purl.obolibrary.org/obo/HP_0004323	Abnormality of body weight		A deviation from normal of the waist to hip ratio, defined as the waist measurement divided by hip measurement.
http://purl.obolibrary.org/obo/HP_0031819	Increased waist to hip ratio	http://purl.obolibrary.org/obo/HP_0031818	Abnormal waist to hip ratio		Increased waist-to-hip ratio (WHR) is a measurement above the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement.
http://purl.obolibrary.org/obo/HP_0031820	Decreased waist to hip ratio	http://purl.obolibrary.org/obo/HP_0031818	Abnormal waist to hip ratio		Decreased waist-to-hip ratio (WHR) is a measurement below the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement.
http://purl.obolibrary.org/obo/HP_0031821	Abnormal hypoxanthine-guanine phosphoribosyltransferase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.
http://purl.obolibrary.org/obo/HP_0031822	Elevated hypoxanthine-guanine phosphoribosyltransferase level	http://purl.obolibrary.org/obo/HP_0031821	Abnormal hypoxanthine-guanine phosphoribosyltransferase level		Abnormally increased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.
http://purl.obolibrary.org/obo/HP_0031823	Reduced hypoxanthine-guanine phosphoribosyltransferase level	http://purl.obolibrary.org/obo/HP_0031821	Abnormal hypoxanthine-guanine phosphoribosyltransferase level		Abnormally decreased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.
http://purl.obolibrary.org/obo/HP_0031824	Hepatic mastocytosis	http://purl.obolibrary.org/obo/HP_0100495	Mastocytosis		Liver mast cell infiltration.
http://purl.obolibrary.org/obo/HP_0031825	Freezing of gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Freezing of gait is defined as a brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk.
http://purl.obolibrary.org/obo/HP_0031827	Absent abdominal reflex	http://purl.obolibrary.org/obo/HP_0031828	Abnormal superficial reflex		Lack of contraction of abdominal muscles in the quadrant of the abdomen that is stimulated by scraping the skin tangential to or toward the umbilicus.
http://purl.obolibrary.org/obo/HP_0031829	Absent cremaster reflex	http://purl.obolibrary.org/obo/HP_0031828	Abnormal superficial reflex		Lack of response to scratching of the skin of the medial thigh, which in males normally elicits a brisk, short elevation of the ipsilateral testis, a phenomenon that is referred to as the cremaster reflex.
http://purl.obolibrary.org/obo/HP_0031830	Pinguecula	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		A pinguecula is a yellowish to brown protruding lesion in the conjunctiva that is easily seen on the nasal and temporal sides of the cornea.
http://purl.obolibrary.org/obo/HP_0031831	Decreased serum zinc	http://purl.obolibrary.org/obo/HP_0008277	Abnormal circulating zinc concentration		A reduced concentration of zinc in the blood.
http://purl.obolibrary.org/obo/HP_0031832	Hypermetric downward saccades	http://purl.obolibrary.org/obo/HP_0007338	Hypermetric saccades		Overshoot of downward saccadic eye movements.
http://purl.obolibrary.org/obo/HP_0031833	Hypometric upward saccades	http://purl.obolibrary.org/obo/HP_0000571	Hypometric saccades		Saccadic undershoot of upward saccadic eye movements, i.e., an upward saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.
http://purl.obolibrary.org/obo/HP_0031834	Aortopulmonary collateral arteries	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus.
http://purl.obolibrary.org/obo/HP_0031835	Abnormal circulating superoxide dismutase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Concentration or activity of superoxide dismutase is above or below the limits of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031836	Increased circulating superoxide dismutase concentration	http://purl.obolibrary.org/obo/HP_0031835	Abnormal circulating superoxide dismutase activity		Concentration or activity of superoxide dismutase is above the upper limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031837	Decreased circulating superoxide dismutase concentration	http://purl.obolibrary.org/obo/HP_0031835	Abnormal circulating superoxide dismutase activity		Concentration or activity of superoxide dismutase is below the lower limit of normal in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031838	Presence of xenobiotic	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Presence of a chemical substance found within an individual that is not naturally produced or expected to be present in human tissues or bodily fluids.
http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic	http://purl.obolibrary.org/obo/HP_0031838	Presence of xenobiotic		The presence of a xenobiotic in urine.
http://purl.obolibrary.org/obo/HP_0031841	Positive urine methadone test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in urine.
http://purl.obolibrary.org/obo/HP_0031843	Abnormally slow thought process	http://purl.obolibrary.org/obo/HP_0025769	Disordered formal thought process		An inner sense from the self that thoughts are abnormally slow and the individual feels that they are unable to increase their rate of thinking. The primary pathology is the decreased rate and other qualities of thinking (e.g. naming of objects) are intact, just slowed. This may be associated with slowed speech, but may be internal and masked by speech that is limited to brief (yes or no) answers.
http://purl.obolibrary.org/obo/HP_0031844	Euphoria	http://purl.obolibrary.org/obo/HP_0100851	Abnormal emotional state		Elevation of emotional tone or mood that significantly deviates from normative affective functioning. This state is characterized by an overwhelming and all-encompassing sense of joyous well-being; it is associated with unfounded grandiosity, or grossly inflated self-esteem, rapid speech, impulsivity, and an impaired capacity for self-regulation, irrespective of context.
http://purl.obolibrary.org/obo/HP_0031845	Abnormal libido	http://purl.obolibrary.org/obo/HP_0008768	Abnormal sexual behavior		Any deviation from the normal sexual drive or desire for sexual activity.
http://purl.obolibrary.org/obo/HP_0031846	Femur fracture	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		A break or crush injury of the thigh bone (femur).
http://purl.obolibrary.org/obo/HP_0031847	Difficulty walking backward	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Reduced ability to walk (ambulate) in a backwards direction.
http://purl.obolibrary.org/obo/HP_0031848	Cock-walk gait	http://purl.obolibrary.org/obo/HP_0031954	Dystonic gait		An abnormality of gait that can be observed in individuals with dystonic posture in which the individual walks with an extended trunk and flexed arms, while strutting on the toes without the heels touching the floor.
http://purl.obolibrary.org/obo/HP_0031849	Sleep-wake inversion	http://purl.obolibrary.org/obo/HP_0006979	Sleep-wake cycle disturbance		A reversal of sleeping habits, with a tendency to sleep during the day and be awake at night.
http://purl.obolibrary.org/obo/HP_0031851	Reduced hematocrit	http://purl.obolibrary.org/obo/HP_0031850	Abnormal hematocrit		A reduction below the normal ratio of the volume of red blood cells to the total volume of blood.
http://purl.obolibrary.org/obo/HP_0031853	Isomerism	http://purl.obolibrary.org/obo/HP_0030853	Heterotaxy		Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other.
http://purl.obolibrary.org/obo/HP_0031856	Hobby horse gait	http://purl.obolibrary.org/obo/HP_0031954	Dystonic gait		An abnormal gait characterized by toe walking, stiff legs, and skipping. The gait pattern has some resemblance to cock-walk gait, but affected individuals are able to improve their dystonic gait by walking backward.
http://purl.obolibrary.org/obo/HP_0031858	Esophageal furrows	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Longitudinal grooves in the surface of the esophagus arranged in a longitudinal fashion (from top to bottom of the esophagus).
http://purl.obolibrary.org/obo/HP_0031860	Abnormal heart rate variability	http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia		Any abnormality in the variability of the time interval between successive heartbeats.
http://purl.obolibrary.org/obo/HP_0031861	Decreased heart rate variability	http://purl.obolibrary.org/obo/HP_0031860	Abnormal heart rate variability		Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.
http://purl.obolibrary.org/obo/HP_0031862	Increased heart rate variability	http://purl.obolibrary.org/obo/HP_0031860	Abnormal heart rate variability		Increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.
http://purl.obolibrary.org/obo/HP_0031863	Bloodstream infectious agent	http://purl.obolibrary.org/obo/HP_0430150	Positive blood infectious agent test		The presence of an infectious agent in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031864	Bacteremia	http://purl.obolibrary.org/obo/HP_0031863	Bloodstream infectious agent		Presence of viable bacteria in the blood.
http://purl.obolibrary.org/obo/HP_0031866	Clasp-knife sign	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		Clasp-knife phenomenon refers to increased muscle tone while bending or stretching a limb, whereby there is a sudden relaxation (decrease in resistance) as the muscle continues to be stretched. This phenomenon has been likened to opening a clasp knife.
http://purl.obolibrary.org/obo/HP_0031867	Neck hypertonia	http://purl.obolibrary.org/obo/HP_0001276	Hypertonia		Increased passive stiffness or tightness of the neck musculature.
http://purl.obolibrary.org/obo/HP_0031868	Optic ataxia	http://purl.obolibrary.org/obo/HP_0001251	Ataxia		Difficulty reaching visually guided goals in peripheral vision, with the deficit, leaves voluntary eye movements largely unaffected.
http://purl.obolibrary.org/obo/HP_0031870	Phosphohydroxylysinuria	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		An elevated concentration of phosphohydroxylysine in the urine.
http://purl.obolibrary.org/obo/HP_0031871	Abnormal Langerhans cell morphology	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles in immune surveillance and homeostasis.
http://purl.obolibrary.org/obo/HP_0031872	Absent Birbeck granules in Langerhans cells	http://purl.obolibrary.org/obo/HP_0031871	Abnormal Langerhans cell morphology		Birbeck granules (BG) are cytoplasmic organelles that are only found in Langerhans cells (LC). The function of BG is still not completely understood, although most studies point toward an active role in receptor-mediated endocytosis and participation in the antigen-processing/presenting function of LC. This feature refers to the absence of BG in LC, a feature that can be documented by means of electron microscopy.
http://purl.obolibrary.org/obo/HP_0031873	Early chronotype	http://purl.obolibrary.org/obo/HP_0006979	Sleep-wake cycle disturbance		A tendency towards rising very early in the morning and going to bed early in the evening.
http://purl.obolibrary.org/obo/HP_0031874	Late chronotype	http://purl.obolibrary.org/obo/HP_0006979	Sleep-wake cycle disturbance		A tendency towards waking up very late in the morning and staying up late at night.
http://purl.obolibrary.org/obo/HP_0031875	Abnormal circulating hepcidin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of hepcidin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031876	Decreased circulating hepcidin concentration	http://purl.obolibrary.org/obo/HP_0031875	Abnormal circulating hepcidin concentration		Concentration of hepcidin in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031877	Elevated circulating hepcidin concentration	http://purl.obolibrary.org/obo/HP_0031875	Abnormal circulating hepcidin concentration		Concentration of hepcidin in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031878	Acromicria	http://purl.obolibrary.org/obo/HP_0002813	Abnormal limb bone morphology		Small hands and feet in proportion to the rest of the body.
http://purl.obolibrary.org/obo/HP_0031879	Abnormal eyelid physiology	http://purl.obolibrary.org/obo/HP_0032040	Abnormal ocular adnexa physiology		Any functional abnormality of the eyelid.
http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity	http://purl.obolibrary.org/obo/HP_0031879	Abnormal eyelid physiology		Abnormally lax eyelid associated with tissue relaxation; it can be demonstrated by the eyelid distraction test and/or the eyelid snap test.
http://purl.obolibrary.org/obo/HP_0031881	Decreased tear drainage	http://purl.obolibrary.org/obo/HP_0009926	Epiphora		A form of watery eye associated with obstruction of the nasolacrimal system. This may arise at the level of the punctum, the canaliculi, the sac or the nasolacrimal duct.
http://purl.obolibrary.org/obo/HP_0031882	Agyria	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		A congenital abnormality of the cerebral hemisphere characterized by lack of gyrations (convolutions) of the cerebral cortex. Agyria is defined as cortical regions lacking gyration with sulci great than 3 cm apart and cerebral cortex thicker than 5 mm.
http://purl.obolibrary.org/obo/HP_0031883	Increased proinsulin:insulin ratio	http://purl.obolibrary.org/obo/HP_0011014	Abnormal glucose homeostasis		An elevated concentration of proinsulin (the prohormone precursor to insulin) to mature insulin in the circulation.
http://purl.obolibrary.org/obo/HP_0031884	Abnormal CSF glucose concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		A deviation from normal concentration of glucose content in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0031885	Hyperglycorrhachia	http://purl.obolibrary.org/obo/HP_0031884	Abnormal CSF glucose concentration		Abnormally high glucose concentration in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0031887	Abnormal chylomicron concentration	http://purl.obolibrary.org/obo/HP_0010979	Abnormal circulating lipoprotein cholesterol concentration		Any deviation from the normal circulating concentration of chylomicrons.
http://purl.obolibrary.org/obo/HP_0031890	Increased urine urobilinogen	http://purl.obolibrary.org/obo/HP_0032472	Abnormal urine urobilinogen level		An elevated concentration of urobilinogen in the urine.
http://purl.obolibrary.org/obo/HP_0031891	Decreased total eosinophil count	http://purl.obolibrary.org/obo/HP_0020064	Abnormal total eosinophil count		Abnormal decrease of absolute number of eosinophils in the blood, per microlitre, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0031898	Rouleaux formation	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells.
http://purl.obolibrary.org/obo/HP_0031901	Elevated total serum tryptase	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormally elevated concentration of total tryptase (alpha and beta tryptase) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031903	Abnormal circulating selenium concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		Any deviation from the normal circulating concentration of selenium.
http://purl.obolibrary.org/obo/HP_0031904	Abnormal total hemolytic complement activity	http://purl.obolibrary.org/obo/HP_0005339	Abnormality of complement system		Any deviation from the normal total hemolytic complement activity in the circulation.
http://purl.obolibrary.org/obo/HP_0031905	Increased total hemolytic complement activity	http://purl.obolibrary.org/obo/HP_0031904	Abnormal total hemolytic complement activity		An abnormally elevated total hemolytic complement activity in the circulation.
http://purl.obolibrary.org/obo/HP_0031907	Anti-mitochondrial M2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of M2 anti-mitochondrial antibody (immunoglobulins) in the serum.
http://purl.obolibrary.org/obo/HP_0031908	Micrographia	http://purl.obolibrary.org/obo/HP_0011446	Abnormality of mental function		Abnormally small-sized handwriting is formally defined as an impairment of fine motor skills, which mainly manifests as a progressive or stable reduction in amplitude during a writing task.
http://purl.obolibrary.org/obo/HP_0410144	Abnormal circulating biotinidase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormality in the biotinidase level, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.
http://purl.obolibrary.org/obo/HP_0410145	Decreased circulating biotinidase concentration	http://purl.obolibrary.org/obo/HP_0410144	Abnormal circulating biotinidase concentration		Concentration of biotinidase in the blood circulation below the lower limit of normal. Biotidinase is an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.
http://purl.obolibrary.org/obo/HP_0410146	Elevated circulating biotinidase concentration	http://purl.obolibrary.org/obo/HP_0410144	Abnormal circulating biotinidase concentration		Concentration of biotinidase in the blood circulation above the upper limit of normal. Biotidinase is an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.
http://purl.obolibrary.org/obo/HP_0410147	Eosinophilic infiltration in the stomach mucosa	http://purl.obolibrary.org/obo/HP_0032064	Gastrointestinal eosinophilia		Infiltration of eosinophils in the stomach mucosa, that is diagnosed by an upper endoscopy and microscopy that shows more than 20 eosinophils per high-power field in association with peripheral eosinophilia and the absence of secondary cause of eosinophilia.
http://purl.obolibrary.org/obo/HP_0410148	Idiopathic anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845	Anaphylactic shock		A rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment.
http://purl.obolibrary.org/obo/HP_0410149	Drug-induced anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845	Anaphylactic shock		A form of anaphylaxis that is triggered by intake of drugs or medications.
http://purl.obolibrary.org/obo/HP_0410151	Eosinophilic infiltration of the esophagus	http://purl.obolibrary.org/obo/HP_0032064	Gastrointestinal eosinophilia		Infiltration of numerous eosinophils (usually greater than 15 per high power field) into the squamous epithelium of the esophagus, and layering of eosinophils on the surface layer of the esophagus.
http://purl.obolibrary.org/obo/HP_0410152	Eosinophilic microabscess formation in the esophagus	http://purl.obolibrary.org/obo/HP_0100633	Esophagitis		The formation of small localized collection of eosinophiles (an eosinophilic microabscess) in the esophagus. Usually clusters of greater than or equal to 4 eosinophils are seen, that appear as exudates or white spots or white plaques.
http://purl.obolibrary.org/obo/HP_0410153	Increased level of methylsuccinic acid in urine	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of methylsuccinic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410154	Elevated circulating myristic acid concentration	http://purl.obolibrary.org/obo/HP_0003455	Elevated circulating long chain fatty acid concentration		The concentration of myristic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410156	Increased level of N-acetylneuraminic acid in urine	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An increase in the level of N-acetylneuraminic acid in the urine.
http://purl.obolibrary.org/obo/HP_0410157	Increased level of N-acetylneuraminic acid in fibroblasts	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		An increase in the level of N-acetylneuraminic acid in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_0410166	Defective interstrand cross-link repair	http://purl.obolibrary.org/obo/HP_0003254	Abnormality of DNA repair		A defect in the of the process of interstrand cross-link repair: removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
http://purl.obolibrary.org/obo/HP_0410167	Abnormal morphology of the chest musculature	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		Any abnormality of the chest muscles.
http://purl.obolibrary.org/obo/HP_0410168	Abnormality of the back musculature	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		Any abnormality of the back muscles.
http://purl.obolibrary.org/obo/HP_0410169	Abnormal morphology of the shoulder musculature	http://purl.obolibrary.org/obo/HP_0001446	Abnormality of the musculature of the upper limbs		A structural abnormality of the shoulder (glenohumeral) muscles, which comprise the rotator cuff (supraspinatus, infraspinatus, teres minor, subscapularis), the deltoid, the latissimus dorsi, and the pectoralis major.
http://purl.obolibrary.org/obo/HP_0410170	Hippocampal atrophy	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		Partial or complete wasting (loss) of hippocampus tissue that was once present.
http://purl.obolibrary.org/obo/HP_0410171	Increased cotinine level	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Increased concentration of cotinine in urine.
http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic	http://purl.obolibrary.org/obo/HP_0031838	Presence of xenobiotic		The presence of a xenobiotic in blood.
http://purl.obolibrary.org/obo/HP_0410173	Increased circulating troponin I concentration	http://purl.obolibrary.org/obo/HP_0500020	Abnormal cardiac biomarker test		An increased concentration of tropnin I in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction.
http://purl.obolibrary.org/obo/HP_0410174	Increased circulating troponin T concentration	http://purl.obolibrary.org/obo/HP_0500020	Abnormal cardiac biomarker test		An increased concentration of tropnin T in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction.
http://purl.obolibrary.org/obo/HP_0410175	Hyperketonemia	http://purl.obolibrary.org/obo/HP_0001946	Ketosis		An increase in the level of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the blood.
http://purl.obolibrary.org/obo/HP_0410176	Abnormal circulating glucose-6-phosphate dehydrogenase concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		An anomaly in the level of glucose-6-phosphate dehydrogenase.
http://purl.obolibrary.org/obo/HP_0410178	Elevated circulating glucose-6-phosphate dehydrogenase activity	http://purl.obolibrary.org/obo/HP_0410176	Abnormal circulating glucose-6-phosphate dehydrogenase concentration		The activity of glucose-6-phosphate dehydrogenase in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410179	Decreased circulating glucose-6-phosphate dehydrogenase activity	http://purl.obolibrary.org/obo/HP_0410176	Abnormal circulating glucose-6-phosphate dehydrogenase concentration		The activity of glucose-6-phosphate dehydrogenase in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0410180	Abnormal glucose-6-phosphate dehydrogenase level in dried blood spot	http://purl.obolibrary.org/obo/HP_0410176	Abnormal circulating glucose-6-phosphate dehydrogenase concentration		An anomaly in the level of glucose-6-phosphate dehydrogenase in a dried blood spot.
http://purl.obolibrary.org/obo/HP_0410181	Increased glucose-6-phosphate dehydrogenase level in dried blood spot	http://purl.obolibrary.org/obo/HP_0410180	Abnormal glucose-6-phosphate dehydrogenase level in dried blood spot		An increase in the level of glucose-6-phosphate dehydrogenase in a dried blood spot.
http://purl.obolibrary.org/obo/HP_0410182	Decreased glucose-6-phosphate dehydrogenase level in dried blood spot	http://purl.obolibrary.org/obo/HP_0410180	Abnormal glucose-6-phosphate dehydrogenase level in dried blood spot		A decrease in the level of glucose-6-phosphate dehydrogenase in a dried blood spot.
http://purl.obolibrary.org/obo/HP_0410183	Abnormal glucose-6-phosphate dehydrogenase level in leukocytes	http://purl.obolibrary.org/obo/HP_0034858	Abnormal leukocyte enzyme concentration or activity		An anomaly in the level of glucose-6-phosphate dehydrogenase in leukocytes.
http://purl.obolibrary.org/obo/HP_0410184	Abnormal erythrocyte glucose-6-phosphate dehydrogenase concentration	http://purl.obolibrary.org/obo/HP_0034737	Abnormal erythrocyte metabolite concentration		An anomaly in the level of glucose-6-phosphate dehydrogenase in red blood cells.
http://purl.obolibrary.org/obo/HP_0410185	Abnormal glucose-6-phosphate dehydrogenase level in tissue	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		An anomaly in the level of glucose-6-phosphate dehydrogenase in tissue.
http://purl.obolibrary.org/obo/HP_0410186	Increased glucose-6-phosphate dehydrogenase level in tissue	http://purl.obolibrary.org/obo/HP_0410185	Abnormal glucose-6-phosphate dehydrogenase level in tissue		An increase in the level of glucose-6-phosphate dehydrogenase in tissue.
http://purl.obolibrary.org/obo/HP_0410187	Decreased glucose-6-phosphate dehydrogenase level in tissue	http://purl.obolibrary.org/obo/HP_0410185	Abnormal glucose-6-phosphate dehydrogenase level in tissue		A decrease in the level of glucose-6-phosphate dehydrogenase in tissue.
http://purl.obolibrary.org/obo/HP_0410188	Decreased erythrocyte glucose-6-phosphate dehydrogenase concentration	http://purl.obolibrary.org/obo/HP_0410184	Abnormal erythrocyte glucose-6-phosphate dehydrogenase concentration		A decrease in the level of glucose-6-phosphate dehydrogenase in red blood cells.
http://purl.obolibrary.org/obo/HP_0410189	Increased erythrocyte glucose-6-phosphate dehydrogenase concentration	http://purl.obolibrary.org/obo/HP_0410184	Abnormal erythrocyte glucose-6-phosphate dehydrogenase concentration		An increase in the level of glucose-6-phosphate dehydrogenase in red blood cells.
http://purl.obolibrary.org/obo/HP_0410190	Decreased glucose-6-phosphate dehydrogenase level in leukocytes	http://purl.obolibrary.org/obo/HP_0410183	Abnormal glucose-6-phosphate dehydrogenase level in leukocytes		A decrease in the level of glucose-6-phosphate dehydrogenase in leukocytes.
http://purl.obolibrary.org/obo/HP_0410191	Increased glucose-6-phosphate dehydrogenase level in leukocytes	http://purl.obolibrary.org/obo/HP_0410183	Abnormal glucose-6-phosphate dehydrogenase level in leukocytes		An increase in the level of glucose-6-phosphate dehydrogenase in leukocytes.
http://purl.obolibrary.org/obo/HP_0410193	Abnormal circulating UDP glucose-4-epimerase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An abnormality in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.
http://purl.obolibrary.org/obo/HP_0410194	Increased circulating UDP glucose-4-epimerase concentration	http://purl.obolibrary.org/obo/HP_0410193	Abnormal circulating UDP glucose-4-epimerase concentration		An increase in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.
http://purl.obolibrary.org/obo/HP_0410195	Decreased circulating UDP glucose-4-epimerase concentration	http://purl.obolibrary.org/obo/HP_0410193	Abnormal circulating UDP glucose-4-epimerase concentration		A decrease in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.
http://purl.obolibrary.org/obo/HP_0410196	Abnormal erythrocyte UDP glucose-4-epimerase concentration	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		An abnormality in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.
http://purl.obolibrary.org/obo/HP_0410197	Increased erythrocyte UDP glucose-4-epimerase concentration	http://purl.obolibrary.org/obo/HP_0410196	Abnormal erythrocyte UDP glucose-4-epimerase concentration		An increase in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.
http://purl.obolibrary.org/obo/HP_0410198	Decreased erythrocyte UDP glucose-4-epimerase concentration	http://purl.obolibrary.org/obo/HP_0410196	Abnormal erythrocyte UDP glucose-4-epimerase concentration		A decrease in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.
http://purl.obolibrary.org/obo/HP_0500086	Optic nerve gray crescent	http://purl.obolibrary.org/obo/HP_0012511	Temporal optic disc pallor		Having a characteristic appearance of a slate gray area of pigmentation within the disk margins that commonly appears along the inferotemporal or temporal neuroretinal rim areas.
http://purl.obolibrary.org/obo/HP_0500087	Peripapillary atrophy	http://purl.obolibrary.org/obo/HP_0012512	Diffuse optic disc pallor		Thinning in the layers of the retina and retinal pigment epithelium around the optic nerve.
http://purl.obolibrary.org/obo/HP_0500089	Optic nerve sheath meningioma	http://purl.obolibrary.org/obo/HP_0002858	Meningioma		A benign tumor of meningothelial cells of the meninges that usually occurs in middle age. It is typically unilateral and there is an association with neurofibromatosis type 2.
http://purl.obolibrary.org/obo/HP_0500090	Periocular capillary hemangioma	http://purl.obolibrary.org/obo/HP_0005306	Capillary hemangioma		A capillary hemangioma surrounding the eyeball but within the orbit.
http://purl.obolibrary.org/obo/HP_0500091	Lymphangioma of the orbit	http://purl.obolibrary.org/obo/HP_0100764	Lymphangioma		A hamartoma of lymph vessels that usually presents in childhood. It tends to increase in size with head-down posture and with the Valsalva maneuver. Superficial lesions are visible as transilluminable cystic spaces of the lid or conjunctiva that may also contain blood. Deep lesions may cause gradual proptosis or present acutely with orbital pain and reduced vision due to hemorrhage.
http://purl.obolibrary.org/obo/HP_0500092	Orbital rhabdomyosarcoma	http://purl.obolibrary.org/obo/HP_0002859	Rhabdomyosarcoma		A mesenchymal tumor that is considered to be the commonest primary orbital malignancy in children. Histologically, it may be differentiated into embryonal, alveolar, and pleomorphic types. It is usually intraconal or within the superior orbit.
http://purl.obolibrary.org/obo/HP_0500093	Food allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Primary food allergies primarily occur as a result (most likely) of gastrointestinal sensitization to predominantly stable food allergens (glycoproteins). A secondary food allergy develops after primary sensitization to airborne allergens (e. g., pollen allergens) with subsequent reactions (due to cross-reactivity) to structurally related often labile allergens in (plant) foods.
http://purl.obolibrary.org/obo/HP_0500094	Latex allergy	http://purl.obolibrary.org/obo/HP_0012393	Allergy		Latex allergy is an IgE-mediated immediate hypersensitivity response to natural rubber latex (NRL) protein with a variety of clinical signs ranging from contact urticaria, angioedema, asthma, and anaphylaxis.
http://purl.obolibrary.org/obo/HP_0500095	Food-induced anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845	Anaphylactic shock		Food-induced anaphylaxis is a severe, potentially fatal, systemic allergic reaction that occurs suddenly after contact with an allergy-causing food.
http://purl.obolibrary.org/obo/HP_0500096	Venom-induced anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845	Anaphylactic shock		A form of anaphylaxis that is triggered by exposure to venom.
http://purl.obolibrary.org/obo/HP_0500097	Stool xenobiotic	http://purl.obolibrary.org/obo/HP_0031838	Presence of xenobiotic		Presence of xenobiotic in stool.
http://purl.obolibrary.org/obo/HP_0500098	Meconium xenobiotic	http://purl.obolibrary.org/obo/HP_0500097	Stool xenobiotic		Presence of a xenobiotic in meconium.
http://purl.obolibrary.org/obo/HP_0500099	Hair xenobiotic	http://purl.obolibrary.org/obo/HP_0031838	Presence of xenobiotic		Presence of xenobiotic in hair.
http://purl.obolibrary.org/obo/HP_0500100	Plasma/serum xenobiotic	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Presence of a xenobiotic in plasma and/or serum.
http://purl.obolibrary.org/obo/HP_0500101	Gastric fluid xenobiotic	http://purl.obolibrary.org/obo/HP_0031838	Presence of xenobiotic		Presence of a xenobiotic in gastric fluid.
http://purl.obolibrary.org/obo/HP_0031938	Abnormal conus terminalis morphology	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		Any structural anomaly of the conus terminalis, which is the distal bulbous part of the spinal cord at the location where the spinal cord tapers and ends (usually between the L1 and L2 lumbar vertebrae).
http://purl.obolibrary.org/obo/HP_0031970	Abnormal blood urea nitrogen concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		Any deviation from the normal concentration of urea nitrogen in the blood.
http://purl.obolibrary.org/obo/HP_0410287	Intrathoracic hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the intrathoracic or chest region.
http://purl.obolibrary.org/obo/HP_0410288	Hyperamylasemia	http://purl.obolibrary.org/obo/HP_0410282	Abnormal circulating amylase concentration		The concentration of amylase in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410289	Hypoamylasemia	http://purl.obolibrary.org/obo/HP_0410282	Abnormal circulating amylase concentration		The concentration of amylase in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0410290	Positive urine norpropoxyphene test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of norpropoxyphene in urine.
http://purl.obolibrary.org/obo/HP_0410291	Negativism	http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition		Opposing or not responding to instructions or external stimuli.
http://purl.obolibrary.org/obo/HP_0410293	Absent circulating isohemagglutinin	http://purl.obolibrary.org/obo/HP_0410292	Abnormal circulating isohemagglutinin concentration		Absent or undetectable level of isohemagglutinin. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person).
http://purl.obolibrary.org/obo/HP_0410294	Decreased specific antibody response to protein vaccine	http://purl.obolibrary.org/obo/HP_0032140	Decreased specific antibody response to vaccination		A reduced ability to synthesize postvaccination antibodies against proteins in vaccines, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410295	Complete or near-complete absence of specific antibody response to tetanus vaccine	http://purl.obolibrary.org/obo/HP_0410294	Decreased specific antibody response to protein vaccine		The inability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410296	Complete or near-complete absence of specific antibody response to hepatitis B vaccine	http://purl.obolibrary.org/obo/HP_0410294	Decreased specific antibody response to protein vaccine		The inability to synthesize postvaccination antibodies against a hepatisis B antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410297	Partial absence of specific antibody response to tetanus vaccine	http://purl.obolibrary.org/obo/HP_0410294	Decreased specific antibody response to protein vaccine		A reduced ability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410298	Partial absence of specific antibody response to hepatitis B vaccine	http://purl.obolibrary.org/obo/HP_0410294	Decreased specific antibody response to protein vaccine		A reduced ability to synthesize postvaccination antibodies against a hepatitis B antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410299	Decreased specific antibody response to unconjugated polysaccharide vaccine	http://purl.obolibrary.org/obo/HP_0032140	Decreased specific antibody response to vaccination		A reduced ability to synthesize postvaccination antibodies against unconjugated polysaccharides in vaccines, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410300	Complete or near-complete absence of specific antibody response to unconjugated pneumococcus polysaccharide	http://purl.obolibrary.org/obo/HP_0410299	Decreased specific antibody response to unconjugated polysaccharide vaccine		The inability to synthesize postvaccination antibodies against a pneumococcus antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410301	Partial absence of specific antibody response to unconjugated pneumococcus polysaccharide	http://purl.obolibrary.org/obo/HP_0410299	Decreased specific antibody response to unconjugated polysaccharide vaccine		A reduced ability to synthesize postvaccination antibodies against a pneumococcus antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410302	Decreased specific antibody response to protein-conjugated polysaccharide vaccine	http://purl.obolibrary.org/obo/HP_0032140	Decreased specific antibody response to vaccination		A reduced ability to synthesize postvaccination antibodies against protein-conjugated polysaccharides in vaccines, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410303	Complete or near-complete absence of specific antibody response to protein-conjugated Haemophilus influenzae type b vaccine	http://purl.obolibrary.org/obo/HP_0410302	Decreased specific antibody response to protein-conjugated polysaccharide vaccine		The inability to synthesize postvaccination antibodies against a protein-conjugated Haemophilus influenzae type b (Hib) antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410304	Complete or near-complete absence of specific antibody response to protein-conjugated meningococcus vaccine	http://purl.obolibrary.org/obo/HP_0410302	Decreased specific antibody response to protein-conjugated polysaccharide vaccine		The inability to synthesize postvaccination antibodies against a protein-conjugated meningococcus antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410305	Partial absence of specific antibody response to protein-conjugated Haemophilus influenzae type b vaccine	http://purl.obolibrary.org/obo/HP_0410302	Decreased specific antibody response to protein-conjugated polysaccharide vaccine		A reduced ability to synthesize postvaccination antibodies against a protein-conjugated Haemophilus influenzae type b (Hib) antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410306	Partial absence of specific antibody response to protein-conjugated meningococcus vaccine	http://purl.obolibrary.org/obo/HP_0410302	Decreased specific antibody response to protein-conjugated polysaccharide vaccine		A reduced ability to synthesize postvaccination antibodies against a protein-conjugated meningococcus antigen, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0410307	Positive stool methadone test	http://purl.obolibrary.org/obo/HP_0500097	Stool xenobiotic		Detection of methadone and its metabolites in the stool.
http://purl.obolibrary.org/obo/HP_0410308	Decreased specific antibody response to infection	http://purl.obolibrary.org/obo/HP_0012475	Impaired specific antibody response		A reduced ability to synthesize antibodies against antigens from an infectious agent or pathogen (such as bacteria, viruses, parasites, etc.), as measured by antibody titer determination following infection.
http://purl.obolibrary.org/obo/CL_0001200	lymphocyte of B lineage, CD19-positive	http://purl.obolibrary.org/obo/CL_0000945	lymphocyte of B lineage		A lymphocyte of B lineage that is CD19-positive.
http://purl.obolibrary.org/obo/CL_0001201	B cell, CD19-positive	http://purl.obolibrary.org/obo/CL_0001200	lymphocyte of B lineage, CD19-positive		A B cell that is CD19-positive.
http://purl.obolibrary.org/obo/CL_0001203	CD8-positive, alpha-beta memory T cell, CD45RO-positive	http://purl.obolibrary.org/obo/CL_0000909	CD8-positive, alpha-beta memory T cell		A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative.
http://purl.obolibrary.org/obo/CL_0008033	decidual pericyte	http://purl.obolibrary.org/obo/CL_2000078	placental pericyte		A pericyte of the decidual vasculature.
http://purl.obolibrary.org/obo/CL_0008034	mural cell	http://purl.obolibrary.org/obo/CL_4033054	perivascular cell		Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.
http://purl.obolibrary.org/obo/CL_0008035	microcirculation associated smooth muscle cell	http://purl.obolibrary.org/obo/CL_0008034	mural cell		Any vascular associated smooth muscle cell that is part of some microcirculatory vessel.
http://purl.obolibrary.org/obo/HP_0032678	Eyelid myoclonia seizure	http://purl.obolibrary.org/obo/HP_0002123	Generalized myoclonic seizure		An eyelid myoclonia seizure is a type of generalized myoclonic seizure which may or may not be associated with loss of awareness.
http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure	http://purl.obolibrary.org/obo/HP_0033259	Non-motor seizure		A type of focal-onset seizure characterized by non-motor signs or symptoms (or behavior arrest) as its initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032792	Tonic seizure	http://purl.obolibrary.org/obo/HP_0020219	Motor seizure		A tonic seizure is a type of motor seizure characterized by unilateral or bilateral limb stiffening or elevation, often with neck stiffening.
http://purl.obolibrary.org/obo/HP_0032860	Generalized non-convulsive status epilepticus without coma	http://purl.obolibrary.org/obo/HP_0032671	Non-convulsive status epilepticus without coma		Generalized non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically generalized. It is a prolonged absence seizure.
http://purl.obolibrary.org/obo/HP_0032943	Abnormal urine pH	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		A deviation of urine pH from the normal range of 4.5 to 7.8.
http://purl.obolibrary.org/obo/PATO_0040042	decreased ratio	http://purl.obolibrary.org/obo/PATO_0002303	decreased object quality		A decreased quality inhering in a bearer by virtue of the bearer's decreased magnitude in proportion to the magnitude of another entity.
http://purl.obolibrary.org/obo/PATO_0040043	increased ratio	http://purl.obolibrary.org/obo/PATO_0002305	increased object quality		An increased quality inhering in a bearer by virtue of the bearer's increased magnitude in proportion to the magnitude of another entity.
http://purl.obolibrary.org/obo/CHEBI_157750	heparan sulfate polyanion	http://purl.obolibrary.org/obo/CHEBI_61660	organic sulfamate oxoanion		A carbohydrate acid derivative anion that is a polyanionic form of heparan sulfate arising from global deprotonation of the carboxy and N-sulfo groups; major species at pH 7.3.
http://purl.obolibrary.org/obo/CHEBI_176843	vitamin B12	http://purl.obolibrary.org/obo/CHEBI_75769	B vitamin		Any member of a group of cobalamin vitamers that exhibit biological activity against vitamin B<small><sub>12</sub></small> deficiency. Vitamin B<small><sub>12</sub></small> deficiency is associated with low red blood cell count and anemia. The vitamers are found in foods such as cereals, meat, fish, and poultry. The vitamers include adenosylcobalamin, hydroxocobalamin, cyanocobalamin, aquacobalamin, nitritocobalamin and methylcobabalamin (also includes their ionized, salt and phosphate derivatives).
http://purl.obolibrary.org/obo/CL_0017500	neutrophillic cytoplasm	http://purl.obolibrary.org/obo/GO_0005737	cytoplasm		Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.
http://purl.obolibrary.org/obo/CL_0017502	acidophilic cytoplasm	http://purl.obolibrary.org/obo/GO_0005737	cytoplasm		Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.
http://purl.obolibrary.org/obo/CL_0017503	basophilic cytoplasm	http://purl.obolibrary.org/obo/GO_0005737	cytoplasm		Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.
http://purl.obolibrary.org/obo/CL_0017504	polychromatophilic cytoplasm	http://purl.obolibrary.org/obo/GO_0005737	cytoplasm		Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.
http://purl.obolibrary.org/obo/UBERON_8410077	airway submucosal gland	http://purl.obolibrary.org/obo/UBERON_0036225	respiratory system gland		A submucosal gland found in a respiratory tract.
http://purl.obolibrary.org/obo/UBERON_0039856	right ovarian vein	http://purl.obolibrary.org/obo/UBERON_0001145	ovarian vein		Ovarian vein, each instance of which is a tributary  of some inferior vena cava that drains the right pampiniform plexus of some broad ligament.
http://purl.obolibrary.org/obo/UBERON_0039857	left ovarian vein	http://purl.obolibrary.org/obo/UBERON_0001145	ovarian vein		Ovarian vein, each instance of which is a tributary  of some left renal vein that drains the left pampiniform plexus of some broad ligament.
http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		An anomalous structural finding of the fetal gastrointestinal system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0034252	Absent corneal reflex	http://purl.obolibrary.org/obo/HP_0034251	Abnormal corneal reflex		Absence of the corneal blinking reflex, which normally induces involuntary blinking of the eyelids following contact of the cornea. The corneal blink reflex is caused by a loop between the trigeminal sensory nerves and the facial motor (VII) nerve innervation of the orbicularis oculi muscles.
http://purl.obolibrary.org/obo/HP_0034253	Eosinophil nuclear hypersegmentation	http://purl.obolibrary.org/obo/HP_0001879	Abnormal eosinophil morphology		An excessive division of the lobes of the nucleus of eosinophils. Eosinophils with more than two nuclear lobes are commonly regarded as hypersegmented, because seventy to ninety percent of peripheral blood eosinophils have two nuclear lobes.
http://purl.obolibrary.org/obo/HP_0034254	Face of the giant panda sign	http://purl.obolibrary.org/obo/HP_0002418	Abnormal midbrain morphology		The face of the giant panda sign on T2-weighted MRI is characterized by preservation of normal signal intensity in the red nuclei and lateral portion of the pars reticulata of the substantia nigra, high signal in the tegmentum, and hypointensity of the superior colliculus. The findings are said to resemble the face of a giant panda.
http://purl.obolibrary.org/obo/HP_0034255	Colovesical fistula	http://purl.obolibrary.org/obo/HP_0100819	Intestinal fistula		An aberrant, pathological communication between the colon and the bladder.
http://purl.obolibrary.org/obo/HP_0034256	Absent dermoepidermal hemidesmosomes	http://purl.obolibrary.org/obo/HP_0032449	Abnormal dermoepidermal hemidesmosome morphology		Lack of demonstrable hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin.
http://purl.obolibrary.org/obo/HP_0034257	C4 nephritic factor positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that recognize C4b2a, the C3 convertase of the classical pathway of complement.
http://purl.obolibrary.org/obo/HP_0034259	Hypoplasia of the midbrain	http://purl.obolibrary.org/obo/HP_0034258	Aplasia/Hypoplasia of the midbrain		A developmental defect characterized by underdevelopment of the mesencephalon.
http://purl.obolibrary.org/obo/HP_0034260	Aplastic zygomatic arch	http://purl.obolibrary.org/obo/HP_0005557	Abnormal zygomatic arch morphology		Developmental defect characterized by the absence of the zygomatic arch.
http://purl.obolibrary.org/obo/HP_0034262	Absent lanugo	http://purl.obolibrary.org/obo/HP_0025723	Abnormal fetal skin morphology		Lack of development of lanugo, the fine, soft, unpigmented hair on the body of a fetus or newborn baby.
http://purl.obolibrary.org/obo/HP_0034263	Abnormal vaginal bleeding	http://purl.obolibrary.org/obo/HP_0034268	Abnormal vaginal physiology		Abnormal vaginal bleeding occurs between menstrual periods, after sex, or after menopause. Menstrual periods that are heavier or last longer than usual or last more than seven days also are considered abnormal.
http://purl.obolibrary.org/obo/HP_0034264	Postcoital vaginal bleeding	http://purl.obolibrary.org/obo/HP_0034263	Abnormal vaginal bleeding		Postcoital bleeding (PCB) consists of spotting or bleeding after sexual intercourse that is not related to a person's menstrual cycle.
http://purl.obolibrary.org/obo/HP_0034265	Mastalgia	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain in the breast.
http://purl.obolibrary.org/obo/HP_0034266	Vaginal bleeding during sex	http://purl.obolibrary.org/obo/HP_0034263	Abnormal vaginal bleeding		Bleeding during sex.
http://purl.obolibrary.org/obo/HP_0034267	Pelvic pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones.
http://purl.obolibrary.org/obo/HP_0034268	Abnormal vaginal physiology	http://purl.obolibrary.org/obo/HP_0030012	Abnormal female reproductive system physiology		Any anomaly of vagina function.
http://purl.obolibrary.org/obo/HP_0034269	Abnormal vaginal discharge	http://purl.obolibrary.org/obo/HP_0034268	Abnormal vaginal physiology		Anomalous amount, odor, or consistency of the fluid or mucus that comes from the vagina
http://purl.obolibrary.org/obo/HP_0034270	Serrated incisors	http://purl.obolibrary.org/obo/HP_0011063	Abnormal incisor morphology		Incisor teeth with irregular edges said to resemble a saw.
http://purl.obolibrary.org/obo/HP_0034271	Copper beaten skull	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Diffuse prominent gyral impressions on the inner table of skull vault said to resemble beaten copper.
http://purl.obolibrary.org/obo/HP_0034272	Perifoveal hypoautofluorescence	http://purl.obolibrary.org/obo/HP_0025159	Hypoautofluorescent retinal lesion		Decreased amount of autofluorescence (emission of fluorescent light from ocular structures in the absence of sodium fluorescein) in the retina in the region surrounding the fovea.
http://purl.obolibrary.org/obo/HP_0034273	Premature sagging cheeks	http://purl.obolibrary.org/obo/HP_0004426	Abnormal cheek morphology		Drooping or sinking of tissues of the cheeks more than would be expected at a given age. Sagging can occur due to a relative excess of skin and/or lack of elastic recoil as well as fat accumulation.
http://purl.obolibrary.org/obo/HP_0034275	Verrucous epidermal nevus	http://purl.obolibrary.org/obo/HP_0010816	Epidermal nevus		A type of epidermal nevus (which represent Blaschkoid hamartomas of the skin that result from mosaic post-zygotic mutations) that appears as skin-colored-to-brown, sharply demarcated, papillomatous papules that coalesce into plaques. The majority of these nevi are either present at birth or occur within the first year of life.
http://purl.obolibrary.org/obo/HP_0034276	Elevated circulating thymidine concentration	http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration		Concentration of thymidine in the blood circulation above the normal range.
http://purl.obolibrary.org/obo/HP_0034277	Elevated circulating deoxyuridine concentration	http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration		Concentration of 2-deoxyuridine in the blood circulation is above the normal range.
http://purl.obolibrary.org/obo/HP_0034278	Multinucleated erythroblast	http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology		Erythroblasts with multiple nuclei. Erythroblasts are nucleated precrusor cells of erythrocytes that are localized to the bone marrow. Normally, erythroblasts have a single nucleus. The abnormal finding of erythrocytes with two or more nuclei may be related to defects in cytokinesis.
http://purl.obolibrary.org/obo/HP_0034279	2,8-dihydroxyadenine crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		The presence of 2,8-dihydroxyadenine crystals in the urine. The crystals appear as round, yellow-brown crystals.
http://purl.obolibrary.org/obo/HP_0034280	Target cells	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		Target cells (codocytes) have a centrally located disk of hemoglobin surrounded by an area of pallor with an outer rim of hemoglobin adjacent to the cell membrane giving the cell the appearance of a target.
http://purl.obolibrary.org/obo/HP_0034282	Subcutaneous ossification	http://purl.obolibrary.org/obo/HP_0011986	Ectopic ossification		Formation of abnormal, extraskeletal bony tissue in the soft tissue beneath the skin. Subcutaneous ossifications may be observed by radiography or by palpation.
http://purl.obolibrary.org/obo/HP_0034283	Increased fecal protoporphyrin concentration	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Abnormally high concentration of protoporphyrin (derivative of porphyrin with propionic acid groups) in feces.
http://purl.obolibrary.org/obo/HP_0034284	Recurrent gingivitis	http://purl.obolibrary.org/obo/HP_0002719	Recurrent infections		Increased susceptibility to gingivitis, as manifested by recurrent or chronic episodes of infections or inflammations of the gums (gingival tissue) that are unusual in frequency or severity for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_0034285	Enteroviral encephalitis	http://purl.obolibrary.org/obo/HP_0033993	Viral encephalitis		Inflammation of the brain related to infection by an enterovirus.
http://purl.obolibrary.org/obo/HP_0034287	Afibrinogenemia	http://purl.obolibrary.org/obo/HP_0011898	Abnormality of circulating fibrinogen		Lack of detectable fibrinogen in the blood circulation.
http://purl.obolibrary.org/obo/CL_4030027	GABAergic amacrine cell	http://purl.obolibrary.org/obo/CL_0011005	GABAergic interneuron		An amacrine cell that uses GABA as a neurotransmitter.
http://purl.obolibrary.org/obo/GO_0140962	multicellular organismal-level chemical homeostasis	http://purl.obolibrary.org/obo/GO_0048878	chemical homeostasis		A homeostatic process involved in the maintenance of a steady state level of a chemical within extracellular body fluids, such as blood, xylem or phloem, of a multicellular organism. This is distinct from maintenance of cellular homeostasis, which occurs within a cell.
http://purl.obolibrary.org/obo/CL_4033001	endothelial cell of arteriole of lymph node	http://purl.obolibrary.org/obo/CL_1000412	endothelial cell of arteriole		A(n) endothelial cell that is part of a(n) arteriole of lymph node.
http://purl.obolibrary.org/obo/HP_0034809	Abnormal sperm physiology	http://purl.obolibrary.org/obo/HP_0000025	Functional abnormality of male internal genitalia		Abnormality of a sperm function including protection of paternal DNA, traversing the female reproductive tract, oocyte localisation, penetration of the zona pellucida, oocyte activation and centriole deposition.
http://purl.obolibrary.org/obo/HP_0034819	Iris nodule	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		The presence of a nodule (small rounded lump of tissue) in the iris.
http://purl.obolibrary.org/obo/HP_0034915	Abnormal anus morphology	http://purl.obolibrary.org/obo/HP_0025033	Abnormal digestive system morphology		A structural anomaly of the anus.
http://purl.obolibrary.org/obo/HP_0034930	Digestive system neoplasm	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system		A tumor (abnormal growth of tissue) of the digestive system.
http://purl.obolibrary.org/obo/HP_0034934	Abnormal circulating 7-dehydrocholesterol concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		Concentration of 7-dehydrocholesterol in the blood circulation outside the limits of normal.
http://purl.obolibrary.org/obo/HP_4000187	Spermatogonial maturation arrest	http://purl.obolibrary.org/obo/HP_0031038	Spermatogenesis maturation arrest		A type of spermatogenesis maturation arrest in which the block of developmental occurs in the spermatogonial stage. Testicular histology shows seminiferous tubules with Sertoli cells and spermatogonial cells but no further differentiated cells like spermatocytes or round spermatids.
http://purl.obolibrary.org/obo/HP_0025805	Absent circulating T cells	http://purl.obolibrary.org/obo/HP_0011839	Abnormal total T cell number		Absence of detectable circulating T cells, commonly characterized as CD3+ lymphocytes, in the blood. These may include both TCR alpha/beta and gamma/delta T cells. Usually, less than 50 T cells per microlitre is considered to be an absence.
http://purl.obolibrary.org/obo/HP_0025807	Decreased natural killer cell degranulation	http://purl.obolibrary.org/obo/HP_0012177	Abnormal natural killer cell physiology		Abnormal decrease of NK cell degranulation in response to stimulation, commonly measured through surface CD107a expression in response to cocultivation with a murine cell line. Other methods may be used by different laboratories.
http://purl.obolibrary.org/obo/HP_0025808	Decreased natural killer cell-induced killing of target cells	http://purl.obolibrary.org/obo/HP_0012177	Abnormal natural killer cell physiology		Abnormal decrease of natural killer (NK) cell cytotoxicity. Assaying NK cytotoxicity involves coculturing NK calls with target cells and measuring the extent of cell death by methods such as luminescence-based (luciferase) assays, biophotonic assays, and flow cytometry-based Cr-release assays.
http://purl.obolibrary.org/obo/HP_0025809	Generalized scaling	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		Desquamation (scaling) involving nearly all of the surface of the skin.
http://purl.obolibrary.org/obo/HP_0025810	Ichthyosis linearis circumflexa	http://purl.obolibrary.org/obo/HP_0008064	Ichthyosis		A type of ichthyosis characterized by migratory, annular and polycyclic erythematous patches with double-edged scales at the periphery of the lesions.
http://purl.obolibrary.org/obo/HP_0025811	Trichorrhexis invaginata	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		A type of hair shaft dysmorphology in which the proximal part of the hair shaft overlaps the distal part, showing a bamboo-like appearance. This feature is pathognomic for Netherton syndrome, and can be ascertained by light microscopy.
http://purl.obolibrary.org/obo/HP_0025812	Seborrheic scales on scalp	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		Fine white-greasy scales on scalp.
http://purl.obolibrary.org/obo/HP_0025813	Eyebrow scaling skin	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		Loss of the outer layer of the epidermis in the area of the eyebrow in large, scale-like flakes.
http://purl.obolibrary.org/obo/HP_0025814	Patchy stratum granulosum of epidermis	http://purl.obolibrary.org/obo/HP_0033806	Abnormal epidermis stratum granulosum morphology		The stratum granulosum of the epidermis (granular layer) displays areas of discontinuity.
http://purl.obolibrary.org/obo/HP_0025815	Absent stratum granulosum of epidermis	http://purl.obolibrary.org/obo/HP_0033806	Abnormal epidermis stratum granulosum morphology		The stratum granulosum of the epidermis (granular layer) cannot be observed.
http://purl.obolibrary.org/obo/HP_0025816	Hypogranulosis	http://purl.obolibrary.org/obo/HP_0033806	Abnormal epidermis stratum granulosum morphology		The height (thickness) of the stratum granulosum of the epidermis (granular layer) is below the lower limit of normal but the stratum granulosum is visible.
http://purl.obolibrary.org/obo/HP_0025817	Psoriasiform acanthosis	http://purl.obolibrary.org/obo/HP_0025092	Epidermal acanthosis		A type of epidermal acanthosis characterized by regular elongated rete ridges.
http://purl.obolibrary.org/obo/HP_0025818	Intraepidermal microabscess formation	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Infiltrating neutrophils in the epidermis, mostly into the stratum corneum. Characteristic for psoriasis.
http://purl.obolibrary.org/obo/HP_0025819	Palmoplantar peeling	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		Splitting within the the upper lyer (stratum corneum) of the epidermis clinically characterized by shedding of dead cells from the outermost layer of skin.
http://purl.obolibrary.org/obo/HP_0025820	Offspring of consanguineous relationship	http://purl.obolibrary.org/obo/HP_0032316	Family history		The parents of the index patient are related as second cousins or closer.
http://purl.obolibrary.org/obo/HP_0025821	Lower eyelid erythema	http://purl.obolibrary.org/obo/HP_0040323	Eyelid erythema		Redness of the skin of the lower eyelid, caused by hyperemia of the capillaries in the lower layers of the skin.
http://purl.obolibrary.org/obo/HP_0025822	Upper eyelid erythema	http://purl.obolibrary.org/obo/HP_0040323	Eyelid erythema		Redness of the skin of the upper eyelid, caused by hyperemia of the capillaries in the lower layers of the skin.
http://purl.obolibrary.org/obo/HP_0025823	Positive provocative functional shoulder test	http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology		Abnormal result of a physical test of the shoulder that attempts to provoke pain in order to diagnosis a specific injury.
http://purl.obolibrary.org/obo/HP_0025824	Decreased neutrophil phagocytosis	http://purl.obolibrary.org/obo/HP_0011990	Abnormal neutrophil physiology		Abnormal decrease of neutrophil phagocytic activity, commonly measured after stimulation with E. coli using flow cytometry.
http://purl.obolibrary.org/obo/HP_0025825	Decreased neutrophil adhesion	http://purl.obolibrary.org/obo/HP_0011990	Abnormal neutrophil physiology		Abnormal decrease of neutrophil adhesion capacity, commonly measured as surface expression of CD18, CD11a or CD11b using flow cytometry.
http://purl.obolibrary.org/obo/HP_0025826	Severely decreased neutrophil count	http://purl.obolibrary.org/obo/HP_0001875	Decreased total neutrophil count		Severe decrease in circulating neutrophils, usually characterized as fewer than 500 neutrophils per microlitre.
http://purl.obolibrary.org/obo/HP_0025827	Abnormal Th1 T cell proportion	http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology		Abnormal increase or decrease of Th1 cells, commonly characterized through the intracellular synthesis of IFNg or surface expression of CXCR3, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies or the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin. Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0025828	Increased Th1 T cell proportion	http://purl.obolibrary.org/obo/HP_0025827	Abnormal Th1 T cell proportion		Abnormal increase of Th1 cells, commonly characterized through the intracellular synthesis of IFNg or surface expression of CXCR3, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies or the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin. Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0025829	Decreased Th1 T cell proportion	http://purl.obolibrary.org/obo/HP_0025827	Abnormal Th1 T cell proportion		Abnormal decrease of Th1 cells, commonly characterized through the intracellular synthesis of IFNg or surface expression of CXCR3, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies or the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin. Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0025830	Abnormal Th17 T cell proportion	http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology		Abnormal increase or decrease of Th17 cells, commonly characterized through the intracellular synthesis of IL-17 or surface expression of CCR6, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies, the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin, or staphylococcal enterotoxin B (SEB). Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0025831	Increased Th17 T cell proportion	http://purl.obolibrary.org/obo/HP_0025830	Abnormal Th17 T cell proportion		Abnormal increase of Th17 cells, commonly characterized through the intracellular synthesis of IL-17 or surface expression of CCR6, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies, the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin, or staphylococcal enterotoxin B (SEB). Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0025832	Decreased Th17 T cell proportion	http://purl.obolibrary.org/obo/HP_0025830	Abnormal Th17 T cell proportion		Abnormal decrease of Th17 cells, commonly characterized through the intracellular synthesis of IL-17 or surface expression of CCR6, measured as proportion of total CD3+CD4+ T cells, usually after stimulation. The stimulation is usually unspecific and may include the use of anti-CD3 beads or antibodies, the use of phorbol-12-myristate-13-acetate (PMA) with ionomycin, or staphylococcal enterotoxin B (SEB). Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0025833	Decreased PMA/ionomycin-induced T-cell proliferation	http://purl.obolibrary.org/obo/HP_0031381	Decreased mitogen-induced T-cell proliferation		Abnormal decrease of T cell proliferation in response to phorbol-12-myristate-13-acetate (PMA) and ionomycin stimulation. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation and strength of stimulation may vary between laboratories.
http://purl.obolibrary.org/obo/HP_0025834	Impaired phytohemagglutinin-induced T lymphocyte transformation	http://purl.obolibrary.org/obo/HP_0031381	Decreased mitogen-induced T-cell proliferation		Def: A reduced rate of T lymphocyte transformation in response to in vitro stimulation to the mitogen phytohemagglutinin (PHA). Following PHA stimulation, T cells normally undergo morphological and biochemical alterations that reflect the transformation into lymphoblasts. There are several methods for quantifying this effect including measuring the uptake of the radioactive marker 3H-TdR, methyl thiazolyl tetrazolium colorimetric analysis (MTT assay), and morphological examination under the microscope or using a hematology analyzer. Various types of stimulation index compare the amount of proliferation between treated and control cells. An impaired test refers to a result in which the amount of stimulation is subnormal.
http://purl.obolibrary.org/obo/HP_0025835	Decreased CD8+ T cell degranulation	http://purl.obolibrary.org/obo/HP_0011840	Abnormal T cell physiology		Abnormal decrease of CD8-positive T cell degranulation in response to stimulation, commonly measured through surface CD107a expression in response to cocultivation with a murine cell line. Other methods may be used by different laboratories.
http://purl.obolibrary.org/obo/HP_0025836	Increased total CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_5210424	Increased total CD8+ T cell number		Abnormal increase of cytotoxic CD3+CD8+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0025837	Abnormal RTE CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0031392	Abnormal CD4+ T cell subset proportion		Abnormal increase or decrease of the recent thymic emmigrant (RTE) CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, with the necessary expression of CD31+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
http://purl.obolibrary.org/obo/HP_0025838	Increased RTE CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0025837	Abnormal RTE CD4+ T cell proportion		Abnormal increase of the recent thymic emmigrant (RTE) CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, with the necessary expression of CD31+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
http://purl.obolibrary.org/obo/HP_0025839	Decreased RTE CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0025837	Abnormal RTE CD4+ T cell proportion		Abnormal decrease of the recent thymic emmigrant (RTE) CD4+ T cell subpopulation, commonly characterized as CD45RA+, CD45RO-, or CD27+, with the necessary expression of CD31+, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. These cells are sometimes also characterized as CD62L+ and CCR7+.
http://purl.obolibrary.org/obo/HP_0025841	Decreased HLA-DR+ CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0025840	Abnormal HLA-DR+ CD4+ T cell proportion		Abnormal reduction of the activated HLA-DR+ CD4+ T cell subpopulation, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0025842	Abnormal HLA-DR+ CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_5200023	Abnormal HLA-DR+ T cell proportion		Abnormal increase or decrease of the activated HLA-DR+ CD8+ T cell subpopulation, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0025843	Increased HLA-DR+ CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0025842	Abnormal HLA-DR+ CD8+ T cell proportion		Abnormal increase of the activated HLA-DR+ CD8+ T cell subpopulation, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0025844	Decreased HLA-DR+ CD8+ T cell proportion	http://purl.obolibrary.org/obo/HP_0025842	Abnormal HLA-DR+ CD8+ T cell proportion		Abnormal decrease of the activated HLA-DR+ CD8+ T cell subpopulation, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0025845	Abnormal TCR repertoire	http://purl.obolibrary.org/obo/HP_0002843	Abnormal T cell morphology		Abnormal distribution of the TCR repertoire expressed on T cells. This usually means oligoclonality (fewer TCR clonotypes compared to a healthy age-matched control) or monoclonality (one dominant TCR clone detected). This may be measured through different methods depending on the lab, but commonly include TCR spectratyping or TCRB CDR3 sequencing.
http://purl.obolibrary.org/obo/HP_0025846	Decreased natural killer cell perforin expression	http://purl.obolibrary.org/obo/HP_0012177	Abnormal natural killer cell physiology		Abnormal decrease of intracellular expression of perforin within NK cells, commonly characterized as CD3-CD19- and CD16+ or CD56+ lymphocytes, ex vivo.
http://purl.obolibrary.org/obo/HP_0025847	Fish allergy	http://purl.obolibrary.org/obo/HP_0410333	Seafood allergy		Hypersensitivity in form of an adverse immune reaction against fish.
http://purl.obolibrary.org/obo/HP_0025848	Shellfish allergy	http://purl.obolibrary.org/obo/HP_0410333	Seafood allergy		Hypersensitivity in form of an adverse immune reaction against shellfish (an aquatic shelled mollusc such as an oyster or mussel, or a crustacean such as a crab or shrimp).
http://purl.obolibrary.org/obo/HP_0025849	Localized along nerve distribution	http://purl.obolibrary.org/obo/HP_0012838	Localized		Refers to findings sich as paresthesias or weakness that are distributed according to the anatomical location of a periperipheral nerve.
http://purl.obolibrary.org/obo/GO_0140041	cellular detoxification of methylglyoxal	http://purl.obolibrary.org/obo/GO_0110095	cellular detoxification of aldehyde		Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal. These may include chemical modification or transport of methylglyoxal away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
http://purl.obolibrary.org/obo/HP_0031711	Asymmetric abdominal aortic aneurysm	http://purl.obolibrary.org/obo/HP_0005112	Abdominal aortic aneurysm		An abdominal aortic aneurysm that is not symmetric around its axis (not axisymmetric).
http://purl.obolibrary.org/obo/PATO_0045038	normal photosensitivity	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A photosensitivity which is relatively normal or average
http://purl.obolibrary.org/obo/CHEBI_140948	fatty acid 18:1	http://purl.obolibrary.org/obo/CHEBI_35366	fatty acid		Any monounsaturated fatty acid containing 18 carbons and 1 double bond.
http://purl.obolibrary.org/obo/HP_0025647	Steroid-sensitive nephrotic syndrome	http://purl.obolibrary.org/obo/HP_0000100	Nephrotic syndrome		A type of nephrotic syndrome in which complete remission (albumin urine dipstick negative/trace or proteinuria <4mg/m2/d or urinary protein to creatinine ratio <200mg/g (<20 mg/mmol) for 3 consecutive days) is achieved within initial 4 weeks of corticosteroid therapy.
http://purl.obolibrary.org/obo/UBERON_0036285	wall of left ventricle	http://purl.obolibrary.org/obo/UBERON_0004784	heart ventricle wall		Wall of ventricle which is continuous with the wall of aorta.
http://purl.obolibrary.org/obo/UBERON_0036286	wall of right ventricle	http://purl.obolibrary.org/obo/UBERON_0004784	heart ventricle wall		Wall of ventricle which is continuous with the wall of pulmonary trunk.
http://purl.obolibrary.org/obo/UBERON_0036293	oral frenulum	http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa		A small fold of mucous membrane in the mouth, connecting either the tongue or the lip to the mouth mucosa.
http://purl.obolibrary.org/obo/UBERON_0036294	mucosa of lip	http://purl.obolibrary.org/obo/UBERON_0003729	mouth mucosa		A mucosa that is part of a lip region [Automatically generated definition].
http://purl.obolibrary.org/obo/CHEBI_144637	4-hydroxy-D-proline	http://purl.obolibrary.org/obo/CHEBI_84185	D-proline derivative		The <small>D</small>-stereoisomer of 4-hydroxyproline.
http://purl.obolibrary.org/obo/CHEBI_144829	tumour antigen	http://purl.obolibrary.org/obo/CHEBI_59132	antigen		An antigenic substance produced in tumour cells, which triggers an immune response in the host.
http://purl.obolibrary.org/obo/CHEBI_145810	insulin	http://purl.obolibrary.org/obo/CHEBI_25905	peptide hormone		A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the β cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies.
http://purl.obolibrary.org/obo/CHEBI_146306	partially-defined glycan	http://purl.obolibrary.org/obo/CHEBI_78616	carbohydrates and carbohydrate derivatives		A member of the class of carbohydrates and carbohydrate derivatives that is any oligosaccharide or polysaccharide in which the identity of one or more of the individual monosaccharide units, their connectivity (position of attachment) or the stereochemistry (α- or β-) of one or more of the glycosidic linkages is not known.
http://purl.obolibrary.org/obo/CHEBI_146500	D-Galp-(1->3)-D-GalpNAc	http://purl.obolibrary.org/obo/CHEBI_146306	partially-defined glycan		An amino disaccharide that is 2-acetamido-2-deoxy-<small>D</small>-galactopyranose in which the hydroxy group at position 3 has been converted to the corresponding <small>D</small>-galactopyranoside. The stereochemistry at the anomeric position in each of the galactopyranose rings is not stated.
http://purl.obolibrary.org/obo/PR_000050025	angiotensinogenase	http://purl.obolibrary.org/obo/PR_000000001	protein		A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.
http://purl.obolibrary.org/obo/CL_0011019	mesothelial cell of epicardium	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		A mesothelial cell that is part of the epicardium.
http://purl.obolibrary.org/obo/CL_0011021	fibroblast of upper back skin	http://purl.obolibrary.org/obo/CL_0011022	fibroblast of skin of back		A fibroblast that is part of upper back skin.
http://purl.obolibrary.org/obo/CL_0011022	fibroblast of skin of back	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		A fibroblast that is part of skin of back.
http://purl.obolibrary.org/obo/CL_0011024	double negative T regulatory cell	http://purl.obolibrary.org/obo/CL_0002489	double negative thymocyte		A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation.
http://purl.obolibrary.org/obo/CL_0019001	tracheobronchial serous cell	http://purl.obolibrary.org/obo/CL_0000313	serous secreting cell		Any serous secreting cell that is part of the tracheobronchial epithelium.
http://purl.obolibrary.org/obo/CL_0019002	tracheobronchial chondrocyte	http://purl.obolibrary.org/obo/CL_0000138	chondrocyte		Any chondrocyte that is part of the tracheobronchial tree.
http://purl.obolibrary.org/obo/CL_0019003	tracheobronchial goblet cell	http://purl.obolibrary.org/obo/CL_0002370	respiratory tract goblet cell		Any goblet cell that is part of the tracheobronchial epithelium.
http://purl.obolibrary.org/obo/HP_0033640	Acetabular erosions	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		Erosion (loss of substance) of the acetabular subchondral cortical bone. The acetabulum is the concave surface that meets with the head of the femur, forming the hip joint.
http://purl.obolibrary.org/obo/HP_0033643	Increased circulating very long-chain fatty acid concentration	http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration		Increased concentration of very long-chain fatty acids in the blood circulation. Very long-chain fatty acids are fatty acids (FAs) with a chain-length of 22 or more carbons.
http://purl.obolibrary.org/obo/HP_0033644	Elevated circulating erythropoietin concentration	http://purl.obolibrary.org/obo/HP_0034442	Abnormal circulating erythropoietin concentration		Increased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production.
http://purl.obolibrary.org/obo/HP_0033645	Midline brainstem cleft	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		A developmental defect characterized by an abnormal cleft (V-shaped indentation of the stalklike part of the brain consisting of the medulla oblongata, the midbrain, and the pons.
http://purl.obolibrary.org/obo/HP_0033646	Absent hippocampal commissure	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		Absence of the fibers that connect the contralateral hippocampi via the crura of the fornix and run beneath the posterior portion of the corpus callosum.
http://purl.obolibrary.org/obo/HP_0033647	Silhouette sign	http://purl.obolibrary.org/obo/HP_0033775	Pulmonary imaging sign		The silhouette sign is the absence of depiction of an anatomic soft-tissue border. It is caused by consolidation and/or atelectasis of the adjacent lung, by a large mass, or by contiguous pleural fluid. The silhouette sign results from the juxtaposition of structures of similar radiographic attenuation. The sign actually refers to the absence of a silhouette.
http://purl.obolibrary.org/obo/HP_0033648	Pulmonary pseudocavity	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		A pseudocavity appears as an oval or round area of low attenuation in lung nodules, masses, or areas of consolidation that represent spared parenchyma, normal or ectatic bronchi, or focal emphysema rather than cavitation. These pseudocavities usually measure less than 1 cm in diameter. They have been described in patients with adenocarcinoma, bronchioloalveolar carcinoma, and benign conditions such as infectious pneumonia.
http://purl.obolibrary.org/obo/HP_0033649	Paraseptal emphysema	http://purl.obolibrary.org/obo/HP_0002097	Emphysema		Paraseptal emphysema is characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa. This emphysema is characterized by subpleural and peribronchovascular regions of low attenuation separated by intact interlobular septa, sometimes associated with bullae.
http://purl.obolibrary.org/obo/HP_0033650	Pulmonary parenchymal band	http://purl.obolibrary.org/obo/HP_0031457	Pulmonary opacity		A parenchymal band is a linear opacity, usually 1-3 mm thick and up to 5 cm long that usually extends to the visceral pleura (which is often thickened and may be retracted at the site of contact). It reflects pleuroparenchymal fibrosis and is usually associated with distortion of the lung architecture. Parenchymal bands are most frequently encountered in individuals who have been exposed to asbestos.
http://purl.obolibrary.org/obo/HP_0033651	Pulmonary mycetoma	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		A mycetoma is a discrete mass of intertwined hyphae, usually of an Aspergillus species, matted together by mucus, fibrin, and cellular debris colonizing a cavity, usually from prior fibrocavitary disease (eg, tuberculosis or sarcoidosis). A mycetoma may move to a dependent location when the patient changes position and may show an air crescent sign. CT scans may show a spongelike pattern and foci of calcification in the mycetoma.
http://purl.obolibrary.org/obo/HP_0033652	Broncholith	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		A broncholith, a calcified peribronchial lymph node that erodes into an adjacent bronchus, is most often the consequence of Histoplasma or tuberculous infection. The imaging appearance is of a small calcific focus in or immediately adjacent to an airway, most frequently the right middle lobe bronchus. Broncholiths are readily identified on CT scans. Distal obstructive changes may include atelectasis, mucoid impaction, and bronchiectasis
http://purl.obolibrary.org/obo/HP_0033653	Bronchocele	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		A bronchocele is bronchial dilatation due to retained secretions (mucoid impaction) usually caused by proximal obstruction, either congenital (eg, bronchial atresia) or acquired (eg, obstructing cancer). A bronchocele is a tubular or branching Y-or V-shaped structure that may resemble a gloved finger. The CT attenuation of the mucus is generally that of soft tissue but may be modified by its composition (eg, high-attenuation material in allergic bronchopulmonary aspergillosis). In the case of bronchial atresia, the surrounding lung may be of decreased attenuation because of reduced ventilation and, thus, perfusion.
http://purl.obolibrary.org/obo/HP_0033654	Beaded septum sign	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Irregular and nodular thickening of interlobular septa reminiscent of a row of beads.
http://purl.obolibrary.org/obo/HP_0033655	Pulmonary cavity	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		A gas-filled space, seen as lucency or low-attenuation area, within a nodule, mass or area of parenchymal consolidations. It has a clearly defined wall over 4 mm thick.
http://purl.obolibrary.org/obo/HP_0033656	Juxtaphrenic peak	http://purl.obolibrary.org/obo/HP_0031457	Pulmonary opacity		A juxtaphrenic peak is a small triangular opacity based at the apex of the dome of a hemidiaphragm, associated with upper lobe volume loss of any cause (eg, postirradiation fibrosis or upper lobectomy). It is most readily appreciated on a frontal chest radiograph. The peak is caused by upward retraction of the inferior accessory fissure or an intrapulmonary septum associated with the pulmonary ligament.
http://purl.obolibrary.org/obo/HP_0033657	Linear atelectasis	http://purl.obolibrary.org/obo/HP_0100750	Atelectasis		Linear atelectasis is a focal area of subsegmental atelectasis with a linear configuration, almost always extending to the pleura. It is commonly horizontal but sometimes oblique or vertical. The thickness of the atelectasis may range from a few millimeters to more than 1 cm.
http://purl.obolibrary.org/obo/HP_0033658	Rounded atelectasis	http://purl.obolibrary.org/obo/HP_0100750	Atelectasis		Rounded atelectasis is rounded collapsed lung associated with invaginated fibrotic pleura and thickened and fibrotic interlobular septa. Most frequently, it is the consequence of an asbestos-induced exudative pleural effusion with resultant pleural scarring, but it may occur with any cause of pleural fibrosis. On chest radiographs, rounded atelectasis appears as a mass abutting a pleural surface, usually in the posterior part of a lower lobe. Distorted vessels have a curvilinear disposition as they converge on the mass (the comet tail sign). The degree of lobar retraction depends on the volume of atelectatic lung. It is almost invariably associated with other signs of pleural fibrosis (eg, blunting of costophrenic angle). CT is more sensitive for the detection and display of the characteristic features of rounded atelectasis. An additional sign is homogeneous uptake of contrast medium in the atelectatic lung.
http://purl.obolibrary.org/obo/HP_0033660	Hand paresthesia	http://purl.obolibrary.org/obo/HP_0031006	Acroparesthesia		Tingling (often referred to as a pins and needles feeling) and numbness in the hand.
http://purl.obolibrary.org/obo/HP_0033661	Air crescent	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		An air crescent is a collection of air in a crescentic shape that separates the wall of a cavity from an inner mass. The air crescent sign is often considered characteristic of either Aspergillus colonization of preexisting cavities or retraction of infarcted lung in angioinvasive aspergillosis. However, the air crescent sign has also been reported in other conditions, including tuberculosis, Wegener granulomatosis, intracavitary hemorrhage, and lung cancer. The crescent can be seen in both plain X-ray and CT scan.
http://purl.obolibrary.org/obo/HP_0033662	Air bronchogram	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		An air bronchogram is a pattern of air-filled (low-attenuation) bronchi on a background of opaque (high-attenuation) airless lung. The sign implies (a) patency of proximal airways and (b) evacuation of alveolar air by means of absorption (atelectasis) or replacement (eg, pneumonia) or a combination of these processes. In rare cases, the displacement of air is the result of marked interstitial expansion (eg, lymphoma).
http://purl.obolibrary.org/obo/HP_0033663	Air trapping	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Air trapping is retention of air in the lung distal to an obstruction (usually partial). Air trapping is seen on end-expiration CT scans as parenchymal areas with less than normal increase in attenuation and lack of volume reduction. Comparison between inspiratory and expiratory CT scans can be helpful when air trapping is subtle or diffuse.
http://purl.obolibrary.org/obo/HP_0033664	Ganglioglioma	http://purl.obolibrary.org/obo/HP_0025170	Neuronal/glioneuronal neoplasm of the central nervous system		Gangliogliomas are rare tumors of the central nervous system. The are WHO grade I and considered low grade. They are well differentiated neuroepithelial tumors consisting of both dysplastic neuronal and neoplastic glial cells.
http://purl.obolibrary.org/obo/HP_0033665	Diminished health-related quality of life	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A reduction in an individual's subjective assessment of his or her sense of well-being and ability to perform social roles.
http://purl.obolibrary.org/obo/HP_0033666	Diminished physical functioning	http://purl.obolibrary.org/obo/HP_0033665	Diminished health-related quality of life		A reduction in the ability to perform activities of daily living as compared to previous abilities because of functional deficits due to illness. The 36-item Short Form (SF-36) health survey questionnaire is one of many methods used to measure patients' perceptions of diminished physical functioning.
http://purl.obolibrary.org/obo/HP_0033667	Diminished mental health	http://purl.obolibrary.org/obo/HP_0033665	Diminished health-related quality of life		A reduction in the subjective feeling of mental well being.
http://purl.obolibrary.org/obo/HP_0033669	Enlarged amygdala	http://purl.obolibrary.org/obo/HP_0033668	Abnormal amygdala morphology		A increase in the volume (size) of the amygdyla.
http://purl.obolibrary.org/obo/HP_0033670	Organizing pneumonia	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities.
http://purl.obolibrary.org/obo/HP_0033671	Pulmonary oligemia	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Oligemia is a reduction in pulmonary blood volume. Most frequently, this reduction is regional, but occasionally it is generalized. Regional oligemia is usually associated with reduced blood flow in the oligemic area. Oligemia appears as a regional or widespread decrease in the size and number of identifiable pulmonary vessels, which is indicative of less than normal blood flow.
http://purl.obolibrary.org/obo/HP_0033672	Positive carpal Tinel sign	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		The Tinel test is performed by lightly tapping (percussing) over the median nerve. It is positive (abnormal) if the patient experiences pain and paresthesias (tingling, numbness) along the distribution of the median nerve.
http://purl.obolibrary.org/obo/HP_0033673	Positive Phalen test	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		The Phalen maneuver is performed by having the patient hold both wrists in complete and forced flexion (pushing the dorsal surfaces of both hands together) for 30-60 seconds. This can increase the pressure in the carpal tunnel. The test is positive (abnormal) if the patient experiences characteristic symptoms of carpal tunnel syndrome (pain and paresthesias along the distribution of the median nerve, i.e., thumb, index finger, and middle finger).
http://purl.obolibrary.org/obo/HP_0033674	Pulmonary blood flow redistribution	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Pulmonary blood flow redistribution refers to any departure from the normal distribution of blood flow in the lungs that is caused by an increase in pulmonary vascular resistance elsewhere in the pulmonary vascular bed. Pulmonary blood flow redistribution is indicated by a decrease in the size and/or number of visible pulmonary vessels in one or more lung regions, with a corresponding increase in number and/or size of pulmonary vessels in other parts of the lung.
http://purl.obolibrary.org/obo/HP_0033678	Acute coronary syndrome	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		The term acute coronary syndrome (ACS) refers to any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI).
http://purl.obolibrary.org/obo/HP_0033684	Abnormal muscle fiber-type distribution	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Ay deviation from the normal distribution of fiber types in skeletal muscle. The skeletal muscle groups of the mammalian body are made up of bundles of muscle fibers. These fibers can be assigned to different Types, with characteristic movement rates, response to neural inputs, and metabolic styles. Skeletal muscle fibers are broadly classified as slow-twitch (type 1) and fast-twitch (type 2). Multiple fiber types are generally intermingled within a single muscle group, and different muscle groups have varying proportions of fiber types
http://purl.obolibrary.org/obo/HP_0033687	Short term memory impairment	http://purl.obolibrary.org/obo/HP_0002354	Memory impairment		A deficit in the retention of pieces of information (memory chunks) for a relatively short time (usually up to 30 seconds).
http://purl.obolibrary.org/obo/HP_0033725	Thin corpus callosum	http://purl.obolibrary.org/obo/HP_0001273	Abnormal corpus callosum morphology		An abnormally thin corpus callous, due to atrophy, hypoplasia or agenesis. This term is intended to be used in situations where it is not known if thinning of the corpus callosum (for instance, as visualized by magnetic resonance tomography) is due to abnormal development (e.g. a leukodystrophy) or atrophy following normal development (e.g. neurodegeneration).
http://purl.obolibrary.org/obo/HP_0033747	Abnormal exteroceptive sensation	http://purl.obolibrary.org/obo/HP_0003474	Somatic sensory dysfunction		A type of somatic sensory dysfunction characterized by abnormality of superficial sensation that is mediated by receptors in skin and mucous membranes.
http://purl.obolibrary.org/obo/HP_0033800	Blistering by anatomical location	http://purl.obolibrary.org/obo/HP_0008066	Abnormal blistering of the skin		Blistering (presence of multiple fluid filled blisters) categorized according to the body site where they occur.
http://purl.obolibrary.org/obo/HP_0033804	Subepidermal blistering	http://purl.obolibrary.org/obo/HP_0033801	Blistering by histological location		A type of blistering in which the lesions are located beneath the epidermis.
http://purl.obolibrary.org/obo/HP_0033835	Abnormal renal vascular morphology	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		Anomalous structure of a blood vessel in the kidney.
http://purl.obolibrary.org/obo/HP_4000059	Abnormal lung development	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		A structural defect associated with abnormal development of the lung.
http://purl.obolibrary.org/obo/PATO_0040048	erythematous	http://purl.obolibrary.org/obo/PATO_0000051	morphology		Red due to increase blood circulation in a defined area.
http://purl.obolibrary.org/obo/CHEBI_176783	vitamin C	http://purl.obolibrary.org/obo/CHEBI_50523	butenolide		Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include <small>L</small>-ascorbic acid and its salt, ionized and oxidized forms.
http://purl.obolibrary.org/obo/CL_4030000	choroidal melanocyte	http://purl.obolibrary.org/obo/CL_0000148	melanocyte		A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses.
http://purl.obolibrary.org/obo/CL_4030002	effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated	http://purl.obolibrary.org/obo/CL_0000791	mature alpha-beta T cell		An alpha-beta memory T cell with the phenotype CD45RA-positive.
http://purl.obolibrary.org/obo/HP_0034305	2:1 atrioventricular block	http://purl.obolibrary.org/obo/HP_0011706	Second degree atrioventricular block		A type of second-degree atrioventricular block in which every other P wave is not conducted through the AV node such that only every other P wave is followed by a QRS complex.
http://purl.obolibrary.org/obo/HP_0034306	Ventricular bigeminy	http://purl.obolibrary.org/obo/HP_0006682	Premature ventricular contraction		An electrocardiographic finding of a normal QRS followed by a premature ventricular contraction; a rhythmic pairing of normal and atypical beats originating in the ventricles in a 1-1 ratio such that an ectopic ventricular beat follows each regular heartbeat.
http://purl.obolibrary.org/obo/HP_0034307	Elevated left ventricular end-diastolic diameter	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		The LV end-diastolic internal diameter was measured from two-dimensional (2D) images in the parasternal long-axis view, timed with mitral valve closure at the level of the mitral valve chordae.
http://purl.obolibrary.org/obo/HP_0034308	Prolonged P wave	http://purl.obolibrary.org/obo/HP_0031595	Abnormal P wave		Abnormal increased in the duration of the P wave, which is a marker of delayed inter-atrial conduction.
http://purl.obolibrary.org/obo/HP_0034309	Multiflagellar spermatozoa	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		Spermatozoa with multiple flagella attached to the sperm head.
http://purl.obolibrary.org/obo/HP_0034310	Post-vaccination yellow fever	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		Infection with the yellow fever virus of the live-attenuated vaccine.
http://purl.obolibrary.org/obo/HP_0034311	Hypoplastic optic chiasm	http://purl.obolibrary.org/obo/HP_0025163	Abnormal optic chiasm morphology		Developmental defect characterized by undergrowth of the optic chiasm.
http://purl.obolibrary.org/obo/HP_0034312	Nocturnal hypoxemia	http://purl.obolibrary.org/obo/HP_0012418	Hypoxemia		Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent.
http://purl.obolibrary.org/obo/HP_0034313	Hyperdynamic left ventricular ejection fraction	http://purl.obolibrary.org/obo/HP_0034314	Abnormal left ventricular ejection fraction		An abnormally increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent.
http://purl.obolibrary.org/obo/HP_0034315	Chronic cough	http://purl.obolibrary.org/obo/HP_0012735	Cough		A persistent cough, defined as a cough lasting longer than eight weeks in adults or longer than four weeks in children.
http://purl.obolibrary.org/obo/HP_0034316	Thinning of the substantia nigra pars compacta	http://purl.obolibrary.org/obo/HP_0045007	Abnormal substantia nigra morphology		Reduced volume of pars compacta of the substantia nigra.
http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		Increased susceptibility to viral infections as manifested by recurrent or severe/invasive viral infection, or by viral infection occurring in an unusual anatomical location.
http://purl.obolibrary.org/obo/HP_0034319	CNS vasculitis with reactivation of varicella-zoster virus	http://purl.obolibrary.org/obo/HP_0034318	Unusual virus reactivation		A vasculopathy in the central nervous system (CNS) following reactivation of varicella-zoster virus due to a productive viral infection of both large and small cerebral arteries.
http://purl.obolibrary.org/obo/HP_0034320	Muscle fiber intracytoplasmic reducing inclusion bodies	http://purl.obolibrary.org/obo/HP_0100303	Muscle fiber cytoplasmatic inclusion bodies		Intracytoplasmic inclusions in myofibers that reduce nitro-blue tetrazolium (NBT) and thus stain strongly with the menadione-NBT stain.
http://purl.obolibrary.org/obo/HP_0034321	Elevated circulating guanidinoacetic acid concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		Concentration of guanidinoacetic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034322	Reduced tissue galactocerebrosidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of galactocerebrosidase (EC 3.2.1.46) below the lower limit of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_0034323	Reduced circulating growth hormone concentration	http://purl.obolibrary.org/obo/HP_0032367	Abnormal circulating growth hormone concentration		Concentration of growth hormone in the blood circulation below normal limits.
http://purl.obolibrary.org/obo/HP_0034324	Brachiocephalic artery aneurysm	http://purl.obolibrary.org/obo/HP_0002617	Vascular dilatation		An abnormal widening (dilatation) of the brachiocephalic artery
http://purl.obolibrary.org/obo/HP_0034325	Common carotid artery aneurysm	http://purl.obolibrary.org/obo/HP_0430021	Abnormal common carotid artery morphology		An abnormal widening (dilatation) of the common carotid artery.
http://purl.obolibrary.org/obo/HP_0034326	Adenomyosis	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		Inappropriate (ectopic) endometrial tissue proliferation within the uterine myometrium, often presenting clinically with painful menses and heavy menstrual bleeding.
http://purl.obolibrary.org/obo/HP_0034327	Posterior corneal stroma punctiform multicolored opacities	http://purl.obolibrary.org/obo/HP_0011492	Abnormal corneal stroma morphology		Thin, punctiform elements of various colors in the posterior stroma of the cornea, immediately anterior to Descemet membrane. The elements are visible to direct and indirect illumination.
http://purl.obolibrary.org/obo/HP_0034328	Fibro-obliterative bile-duct lesion	http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology		A condition in which the lumen of a bile duct has been filled by fibrous scar material, in effect replacing the bile duct with a fibrous scar.
http://purl.obolibrary.org/obo/HP_0034329	Dysplastic megalencephaly	http://purl.obolibrary.org/obo/HP_0001355	Megalencephaly		A congenital brain malformation characterized by marked overgrowth and dysplasia affecting one or both cerebral hemispheres, and, in some cases, subcortical brain regions as well. The presence of dysplasia in dysplastic megalencephaly distinguishes it from other forms of generalized megalencephaly.
http://purl.obolibrary.org/obo/HP_0034330	Regional right ventricular hypokinesis	http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function		Decreased range of right ventricular motion in a portion of the right ventricle of the heart.
http://purl.obolibrary.org/obo/HP_0034331	McConnell sign	http://purl.obolibrary.org/obo/HP_0034330	Regional right ventricular hypokinesis		Severe hypokinesia of the mid-free wall of the right ventricle of the heart with a normal contraction of the apical segment of the right ventricle.
http://purl.obolibrary.org/obo/HP_0034332	Cognitive regression	http://purl.obolibrary.org/obo/HP_0002376	Developmental regression		Loss of cognitive developmental skills, as manifested by loss of developmental cognitive milestones.
http://purl.obolibrary.org/obo/HP_0034333	Increased circulating hypoxanthine concentration	http://purl.obolibrary.org/obo/HP_0004368	Elevated circulating purine concentration		Elevated concentration of hypoxanthine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034336	Splenic infarction	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Ischemia and necrosis of part or all of the spleen resulting from compromise of blood supply resulting from arterial or venous occlusion.
http://purl.obolibrary.org/obo/HP_0034337	Claw hand deformity	http://purl.obolibrary.org/obo/HP_0009473	Joint contracture of the hand		An abnormality of the hand characterized by metacarpophalangeal (MCP) hyperextension and proximal interphalangeal (PIP) and distal interphalangeal (DIP) flexion. The position of the affected hand is said to resemble a claw.
http://purl.obolibrary.org/obo/HP_0034339	Pseudoautosomal inheritance	http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance		A pattern of inheritance observed for alleles in the X-Y identical regions is referred to as pseudoautosomal inheritance, because it resembles the pattern seen for alleles located on autosomes.
http://purl.obolibrary.org/obo/HP_0034340	Pseudoautosomal dominant inheritance	http://purl.obolibrary.org/obo/HP_0034339	Pseudoautosomal inheritance		A type of pseudoautosomal inheritance that is dominant and in which heterozygous males and females both manifest a disease phenotype.
http://purl.obolibrary.org/obo/HP_0034341	Pseudoautosomal recessive inheritance	http://purl.obolibrary.org/obo/HP_0034339	Pseudoautosomal inheritance		A type of pseudoautosomal inheritance that is recessive and in which biallelic males and females both manifest a disease phenotype.
http://purl.obolibrary.org/obo/HP_0034342	Trapezius muscle aplasia	http://purl.obolibrary.org/obo/HP_0011006	Abnormal morphology of the musculature of the neck		A developmental defect characterized by lack of formation of the trapezius muscle, which is broad superficial muscle that extends from the posterior neck to the posterior part of the trunk (thorax).
http://purl.obolibrary.org/obo/HP_0034343	Requires heterozygosity	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		A rarely encountered phenomenon in which condition is most severe in the heterozygous state. Such disorders are rare and currently all are X-linked. Most X-linked recessive conditions manifest if hemizygous in males, or biallelic in females, though may have a mild phenotype in the heterozygous state in females.
http://purl.obolibrary.org/obo/HP_0034344	Female-limited expression	http://purl.obolibrary.org/obo/HP_0001470	Sex-limited expression		Used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in the female sex.
http://purl.obolibrary.org/obo/HP_0034346	Nesidioblastosis	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		An abnormality of pancreatic beta cells characterized by a proliferation of abnormal beta cells throughout the entire pancreas, with enlarged islet size and number (hypertrophic islets), increased periductular islets, enlarged beta-cell nuclei and abundant clear cytoplasm. Occasionally beta cells with pleomorphic nuclei, ductuloinsular complexes, and neoformation of islets from ducts are observed.
http://purl.obolibrary.org/obo/HP_0034347	Greater auricular nerve thickening	http://purl.obolibrary.org/obo/HP_3000048	Abnormal great auricular nerve morphology		Increase in thickness of the great auricular nerve, a cutaneous nerve of the head. It originates from the cervical plexus, with branches of spinal nerves C2 and C3. Thickening may lead to the nerve being palpable or even visible in this region.
http://purl.obolibrary.org/obo/HP_0034348	Subpulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001642	Pulmonic stenosis		A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately below the pulmonary valve.
http://purl.obolibrary.org/obo/HP_0034349	Supravalvar pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001642	Pulmonic stenosis		A cardiovascular malformation associated with narrowing at the level of the pulmonary sinotubular junction above the pulmonic valve.
http://purl.obolibrary.org/obo/HP_0034350	Valvular pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0001642	Pulmonic stenosis		A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately at the level of the pulmonary valve.
http://purl.obolibrary.org/obo/HP_0034351	Neuromyotonia	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		Peripheral nerve hyperexcitability manifesting as spontaneous discharges originating from motor axons or their terminals, lead to overactivity of muscles, typically manifesting as twitches, cramps and stiffness.
http://purl.obolibrary.org/obo/HP_0034352	Bile duct polyp	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		An elevated growth from the the mucosa of the bile duct.
http://purl.obolibrary.org/obo/HP_0034354	Trichoschisis	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		Transverse fractures through the hair shafts (trichoschisis). Trichoschisis is characterized by a sharp transverse fracture of the hair shaft.
http://purl.obolibrary.org/obo/HP_0034355	White cerebellum sign	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		On computed tomography of the brain,the white (or dense) cerebellum sign is seen when the cerebellum appears dense with respect to the cerebral parenchyma. The increase in attenuation of cerebellum is in fact a relative hyperdensity caused by decreased attenutation of the brain. It represents anoxic-ischemic cerebral injury, and has a very poor prognosis.
http://purl.obolibrary.org/obo/HP_0034356	Impaired renal tubular reabsorption of low molecular weight protein	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Increased loss of low-molecular weight proteins by the kidneys, measured in terms of the fractional excretion (FE). The FE of low-molecular-weight proteins such as beta2-microglobulin can be measured in terms of plasma and urine concentrations, since urinary low-molecular-weight protein concentrations can vary with water reabsorption.
http://purl.obolibrary.org/obo/HP_0034357	Impaired renal tubular reabsorption of glucose	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Increased fractional excretion (FE) of glucose in the urine. The FE of glucose is the percentage of the glucose filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine glucose, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption.
http://purl.obolibrary.org/obo/HP_0034358	Impaired renal tubular reabsorption of sodium	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Increased fractional excretion (FE) of sodium in the urine. The FE of sodium is the percentage of the sodium filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption.
http://purl.obolibrary.org/obo/HP_0034359	Impaired renal tubular reabsorption of phosphate	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		Increased fractional excretion (FE) of glucose in the phosphate. The FE of glucose is the percentage of the phosphate filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine phosphate, rather than by the interpretation of urinary phosphate concentration alone, as urinary glucose concentrations can vary with water reabsorption.
http://purl.obolibrary.org/obo/HP_0034360	Action myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		A type of myoclonus (arrhythmic muscular jerking) that is induced by voluntary movement. It is made worse by attempts at precise or coordinated movement (intention myoclonus) and may also be provoked by certain sensory stimuli.
http://purl.obolibrary.org/obo/HP_0034361	Redundant umbilical skin	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		Greater than normal amount of skin surrounding the umbilicus (belly button) with protrusion of the umbilicus above the plane of the abdomen.
http://purl.obolibrary.org/obo/HP_0034362	Dull foveal reflex	http://purl.obolibrary.org/obo/HP_0000493	Abnormal foveal morphology		Reduced brightness of the foveal reflex, which normally is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope.
http://purl.obolibrary.org/obo/HP_0034363	Corneal pterygium	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Corneal pterygium is an ocular surface disease characterized mainly by a wing-shaped growth of limbal and conjunctival tissue over the adjacent cornea.
http://purl.obolibrary.org/obo/HP_0034364	Fibrofatty replacement of right ventricular myocardium	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		Replacement of the myocardium of the right ventricular free wall by fat and fibrous tissue.
http://purl.obolibrary.org/obo/HP_0034365	Elevated circulating alpha-aminoadipic semialdehyde concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		Increased concentration of alpha-aminoadipic semialdehyde in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034366	Fracture blister	http://purl.obolibrary.org/obo/HP_0033800	Blistering by anatomical location		Fracture blister is a type of blister that forms following acute bone fractures, typically near the ankle, wrist elbow or foot, where skin adheres tightly to bone with little subcutaneous fat cushioning. The blister that results resembles that of a second degree burn.
http://purl.obolibrary.org/obo/HP_0034367	Decreased circulating beta-mannosidase activity	http://purl.obolibrary.org/obo/HP_0034725	Abnormal circulating beta-mannosidase activity		Activity of the enzyme beta-mannosidase below the lower limit of normal. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides.
http://purl.obolibrary.org/obo/HP_0034368	Urolithiasis	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		Renal stones are formed within the kidneys, and this is called nephrolithiasis. Urolithiasis is a condition that occurs when these stones exit the renal pelvis and move into the remainder of the urinary collecting system, which includes the ureters, bladder, and urethra.
http://purl.obolibrary.org/obo/HP_0034369	Decreased level of coenzyme Q10 in skeletal muscle	http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration		Reduced amount of coenzyme Q10,a naturally occurring quinone, in skeletal muscle tissue.
http://purl.obolibrary.org/obo/HP_0034371	Decreased circulating prekallikrein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of prekallikrein in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034373	External tibial torsion	http://purl.obolibrary.org/obo/HP_0100694	Tibial torsion		External twisting of the tibia resulting in the toes of each foot pointing outward (outtoeing) .
http://purl.obolibrary.org/obo/HP_0034374	Trident acetabulum	http://purl.obolibrary.org/obo/HP_0010454	Acetabular spurs		Abnormal appearance of the acetabulum characterized by spurs at the medial and lateral acetabular margin and in the center of the acetabulum, giving rise to shape resembling a three-pronged spear sadi to resemble a trident.
http://purl.obolibrary.org/obo/HP_0034377	Single atrioventricular valve regurgitation	http://purl.obolibrary.org/obo/HP_0034376	Atrioventricular valve regurgitation		Regurgitation of the single atrioventricular valve regurgitation (AVVR) in the context of a congenital heart defect with a single ventricle. Roughly three quarters of patients following Fontan procedure display AVVR.
http://purl.obolibrary.org/obo/HP_0034380	Juvenile type testicular granulosa cell tumor	http://purl.obolibrary.org/obo/HP_0010788	Testicular neoplasm		Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia.
http://purl.obolibrary.org/obo/HP_0034381	Central nervous system axonal spheroid	http://purl.obolibrary.org/obo/HP_0002011	Morphological central nervous system abnormality		Axonal spheroids are bubble-like biological features that form on most degenerating axons. During neurodegeneration, bubble-like swellings form along the length of the axon, a primary and early effect of dynamic axonal deformation. These varicosities, spheroids, or swellings have been described as beads on a string and branches bearing fruit, and they frequently appear on degenerating axons. The focal swellings on degenerating axons, axonal spheroids, are often filled with cellular debris such as organelles, pathological proteins, and disorganized cytoskeletal elements.
http://purl.obolibrary.org/obo/HP_0034382	Disease remission	http://purl.obolibrary.org/obo/HP_0031797	Clinical course		A decrease in or disappearance of signs and symptoms typically associated with a disease course.
http://purl.obolibrary.org/obo/HP_0034383	Elevated circulating biliverdin concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		Increased concentration of biliverdin, a green tetrapyrrolic bile pigment, in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034384	Elevated circulating insulin:C-peptide ratio	http://purl.obolibrary.org/obo/HP_0040214	Abnormal circulating insulin concentration		Increased ratio of insulin to C-peptide in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034385	Abnormal left ventricular endsystolic diameter	http://purl.obolibrary.org/obo/HP_0025169	Left ventricular systolic dysfunction		A deviation from the normal range of the left ventricular endsystolic diameter.
http://purl.obolibrary.org/obo/HP_0034386	Reduced left ventricular endsystolic diameter	http://purl.obolibrary.org/obo/HP_0034385	Abnormal left ventricular endsystolic diameter		A lower than normal left ventricular endsystolic diameter.
http://purl.obolibrary.org/obo/HP_0034387	Bacterial encephalitis	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		Encephalitis caused by bacterial infection.
http://purl.obolibrary.org/obo/HP_0034388	Hilar lymph node enlargement	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Hilar lymphadenopathy is swelling or enlargement of lymph nodes localized in hila, wedge-shaped anatomical structures containing pulmonary vessels, major bronchi, nerves and lymph nodes. Hilar lymph nodes are not visible on chest X-ray if they are not enlarged. Hilar lymph node enlargement can be caused by benign and malignant conditions and can be symmetrical (bilateral) or asymmetrical (unilateral).
http://purl.obolibrary.org/obo/HP_0034389	Pulmonary vein varix	http://purl.obolibrary.org/obo/HP_0030968	Abnormal pulmonary vein morphology		Pulmonary vein varix (PVV), refers to a localized dilatation of a pulmonary vein. PVV is a rare condition and can be congenital or acquired. PVV typically occur at the confluence of the veins adjacent to the left atrium. PVVs are sometimes classified into three morphological types: saccular, tortuous and confluent.
http://purl.obolibrary.org/obo/HP_0034390	Decreased CSF glycine concentration	http://purl.obolibrary.org/obo/HP_0500229	Abnormal CSF glycine concentration		Abnormally decreased levels of glycine in cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0034393	Elbow extension contracture	http://purl.obolibrary.org/obo/HP_0034391	Elbow contracture		An elbow contracture that limits the ability of the elbow joint to flex (flexion of the the elbow joint refers to bending the elbow joint to bring the hand closer to the shoulder), meaning that the elbow is fixed in an extended (straight) position.
http://purl.obolibrary.org/obo/HP_0034394	Forearm supination contracture	http://purl.obolibrary.org/obo/HP_0100360	Upper-limb joint contracture		A contracture that limits the ability of the forearm to stabilize the hand in pronation (pronation refers to a rotation of the forearm that causes the palm and forearm to face downwards), meaning that the palm is fixed in a upward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between.
http://purl.obolibrary.org/obo/HP_0034395	Forearm pronation contracture	http://purl.obolibrary.org/obo/HP_0100360	Upper-limb joint contracture		A contracture that limits the ability of the forearm to stabilize the hand in supiation (supination refers to a rotation of the forearm that causes the palm and forearm to face upwards), meaning that the palm is fixed in a downward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between.
http://purl.obolibrary.org/obo/HP_4000087	Abnormal communicative facial expressions	http://purl.obolibrary.org/obo/HP_0000758	Abnormal nonverbal communicative behavior		Abnormal expressions (movements or position of muscles of the face that convey the emotional state of an individual to observers during social interactions) comprising abnormalities of quantity, range, context-appropriateness, and quality.
http://purl.obolibrary.org/obo/HP_4000088	Facial expressions that do not match the context	http://purl.obolibrary.org/obo/HP_4000087	Abnormal communicative facial expressions		Production of facial expressions that are misaligned with the social context.
http://purl.obolibrary.org/obo/HP_4000089	Abnormal quality of facial expression	http://purl.obolibrary.org/obo/HP_4000087	Abnormal communicative facial expressions		Spontaneous production of communicative facial expressions that have poor quality or are exaggerated or muted.
http://purl.obolibrary.org/obo/HP_4000090	Abnormal gesture use	http://purl.obolibrary.org/obo/HP_0000758	Abnormal nonverbal communicative behavior		Abnormality in the use of gestures defined as hand, shoulder, and head movements that convey a shared meaning within a culture that replace or supplement verbal communication.
http://purl.obolibrary.org/obo/HP_4000092	Poor conversational reciprocity	http://purl.obolibrary.org/obo/HP_5200136	Reduced social reciprocity		Reduced use of reciprocal (back and forth) conversation, as compared to what would be expected for language level.
http://purl.obolibrary.org/obo/CL_4033013	suprabasal keratinocyte	http://purl.obolibrary.org/obo/CL_4052061	epidermal keratinocyte		A keratinocyte that resides in the epidermal suprabasal layer and expresses differentiation markers, including keratin 1 and keratin 10, in both humans and mice. In human interfollicular epidermis, this cell retains proliferative capacity and possesses retrodifferentiation potential, acquiring basal-like properties during wound healing or basement membrane contact.
http://purl.obolibrary.org/obo/HP_0025732	Abnormal social development	http://purl.obolibrary.org/obo/HP_0012433	Abnormal social behavior		A substantial lag in the achievement of or divergence from typical milestones in social interaction and communication skills. Social-emotional competencies in young children include helping, sharing, comforting, and exhibiting empathy and compliance.
http://purl.obolibrary.org/obo/CL_0001066	erythroid progenitor cell, mammalian	http://purl.obolibrary.org/obo/CL_0000038	erythroid progenitor cell		A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).
http://purl.obolibrary.org/obo/CL_0008017	adult skeletal muscle myoblast	http://purl.obolibrary.org/obo/CL_0000515	skeletal muscle myoblast		A skeletal muscle myoblast that is part of a skeletal mucle.  These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.
http://purl.obolibrary.org/obo/CL_0008019	mesenchymal cell	http://purl.obolibrary.org/obo/CL_0000219	motile cell		A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
http://purl.obolibrary.org/obo/CL_0008022	endocardial cushion cell	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.
http://purl.obolibrary.org/obo/CL_0011007	paraxial cell	http://purl.obolibrary.org/obo/CL_0000222	mesodermal cell		A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.
http://purl.obolibrary.org/obo/CL_0011012	neural crest cell	http://purl.obolibrary.org/obo/CL_0002321	embryonic cell (metazoa)		A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.
http://purl.obolibrary.org/obo/CL_2000007	articular chondrocyte of knee joint	http://purl.obolibrary.org/obo/CL_1001607	articular chondrocyte		Chondrocyte forming the hyaline cartilage found in the knee joint.
http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell		Any blood vessel endothelial cell that is part of a microvascular endothelium.
http://purl.obolibrary.org/obo/CL_2000010	dermis blood vessel endothelial cell	http://purl.obolibrary.org/obo/CL_0000071	blood vessel endothelial cell		Any blood vessel endothelial cell that is part of a dermis.
http://purl.obolibrary.org/obo/CL_2000011	dermis lymphatic vessel endothelial cell	http://purl.obolibrary.org/obo/CL_0002138	endothelial cell of lymphatic vessel		Any endothelial cell of lymphatic vessel that is part of a dermis.
http://purl.obolibrary.org/obo/CL_2000012	fibroblast of pedal digit skin	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		Any skin fibroblast that is part of a pedal digit skin.
http://purl.obolibrary.org/obo/CL_2000013	fibroblast of skin of abdomen	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		Any skin fibroblast that is part of a skin of abdomen.
http://purl.obolibrary.org/obo/CL_2000014	fibroblast of upper leg skin	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		Any skin fibroblast that is part of a upper leg skin.
http://purl.obolibrary.org/obo/CL_2000015	fibroblast of arm	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		Any skin fibroblast that is part of a arm.
http://purl.obolibrary.org/obo/CL_2000016	lung microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		Any lung endothelial cell that is part of a microvascular endothelium.
http://purl.obolibrary.org/obo/CL_2000017	fibroblast of peridontal ligament	http://purl.obolibrary.org/obo/CL_0002556	fibroblast of periodontium		Any fibroblast that is part of a periodontal ligament.
http://purl.obolibrary.org/obo/CL_2000018	endothelial cell of coronary artery	http://purl.obolibrary.org/obo/CL_1000413	endothelial cell of artery		Any endothelial cell of artery that is part of a coronary artery.
http://purl.obolibrary.org/obo/CL_2000020	inner cell mass cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any native cell that is part of a inner cell mass.
http://purl.obolibrary.org/obo/CL_2000021	sebaceous gland cell	http://purl.obolibrary.org/obo/CL_0000255	eukaryotic cell		Any native cell that is part of a sebaceous gland.
http://purl.obolibrary.org/obo/CL_2000022	cardiac septum cell	http://purl.obolibrary.org/obo/CL_0002494	cardiocyte		Any native cell that is part of a cardiac septum.
http://purl.obolibrary.org/obo/CL_2000023	spinal cord ventral column interneuron	http://purl.obolibrary.org/obo/CL_0005000	spinal cord interneuron		Any interneuron that is part of a spinal cord ventral column.
http://purl.obolibrary.org/obo/CL_2000025	spinal cord oligodendrocyte	http://purl.obolibrary.org/obo/CL_0000128	oligodendrocyte		Any oligodendrocyte that is part of a spinal cord.
http://purl.obolibrary.org/obo/CL_2000027	cerebellar basket cell	http://purl.obolibrary.org/obo/CL_0000118	basket cell		A GABAergic inhibitory interneuron located in the molecular layer of the cerebellar cortex. It projects axons that form specialized synaptic structures around Purkinje cells, including pericellular baskets, which wrap around the Purkinje cell soma, and the pinceau: a brush-like terminal that contacts the initial segment of the Purkinje cell axon. The basket cell modulates Purkinje cell activity through both chemical (GABAergic) and non-synaptic (ephaptic) mechanisms. It is arranged in sagittal rows that align with Purkinje cell zones, contributing to the cerebellum's modular and topographically organized architecture. It plays an essential role in regulating motor coordination and potentially cognitive functions.
http://purl.obolibrary.org/obo/CL_2000028	cerebellum glutamatergic neuron	http://purl.obolibrary.org/obo/CL_1001611	cerebellar neuron		Any glutamatergic neuron that is part of a cerebellum.
http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		Any neuron that is part of a central nervous system.
http://purl.obolibrary.org/obo/CL_2000030	hypothalamus cell	http://purl.obolibrary.org/obo/CL_0002319	neural cell		Any native cell that is part of a hypothalamus.
http://purl.obolibrary.org/obo/CL_2000032	peripheral nervous system neuron	http://purl.obolibrary.org/obo/CL_0000540	neuron		A neuron that is part of a peripheral nervous system.
http://purl.obolibrary.org/obo/CL_2000033	limb basal cell of epidermis	http://purl.obolibrary.org/obo/CL_0002187	basal cell of epidermis		Any basal cell of epidermis that is part of a limb.
http://purl.obolibrary.org/obo/CL_2000040	bladder microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		Any microvascular endothelial cell that is part of a urinary bladder.
http://purl.obolibrary.org/obo/CL_2000041	dermis microvascular lymphatic vessel endothelial cell	http://purl.obolibrary.org/obo/CL_0011030	dermal microvascular endothelial cell		Any dermis lymphatic vessel endothelial cell that is part of a microvascular endothelium.
http://purl.obolibrary.org/obo/CL_2000042	embryonic fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		Any fibroblast that is part of a embryo.
http://purl.obolibrary.org/obo/CL_2000043	brain pericyte	http://purl.obolibrary.org/obo/CL_0002575	central nervous system pericyte		Any pericyte cell that is part of a brain.
http://purl.obolibrary.org/obo/CL_2000044	brain microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		Any microvascular endothelial cell that is part of a brain.
http://purl.obolibrary.org/obo/CL_2000045	foreskin melanocyte	http://purl.obolibrary.org/obo/CL_1000458	melanocyte of skin		Any melanocyte of skin that is part of a skin of prepuce of penis.
http://purl.obolibrary.org/obo/CL_2000046	ventricular cardiac muscle cell	http://purl.obolibrary.org/obo/CL_0000746	cardiac muscle cell		Any cardiac muscle cell that is part of a cardiac ventricle.
http://purl.obolibrary.org/obo/CL_2000047	brainstem motor neuron	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		Any motor neuron that is part of a brainstem.
http://purl.obolibrary.org/obo/CL_2000051	splenic fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		Any fibroblast that is part of a spleen.
http://purl.obolibrary.org/obo/CL_2000052	umbilical artery endothelial cell	http://purl.obolibrary.org/obo/CL_1000413	endothelial cell of artery		Any endothelial cell of artery that is part of a umbilical cord.
http://purl.obolibrary.org/obo/CL_2000053	splenic endothelial cell	http://purl.obolibrary.org/obo/CL_0000115	endothelial cell		Any endothelial cell that is part of a spleen.
http://purl.obolibrary.org/obo/CL_2000055	liver dendritic cell	http://purl.obolibrary.org/obo/CL_0000451	dendritic cell		Any dendritic cell that is part of a liver.
http://purl.obolibrary.org/obo/CL_2000059	prostate gland microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		Any microvascular endothelial cell that is part of a prostate gland.
http://purl.obolibrary.org/obo/CL_2000061	placental amniotic mesenchymal stromal cell	http://purl.obolibrary.org/obo/CL_0000134	mesenchymal stem cell		Any mesenchymal stem cell that is part of a placenta.
http://purl.obolibrary.org/obo/CL_2000062	placental villus capillary endothelial cell	http://purl.obolibrary.org/obo/CL_0009092	endothelial cell of placenta		Any capillary endothelial cell that is part of a placenta.
http://purl.obolibrary.org/obo/CL_2000063	ovarian fibroblast	http://purl.obolibrary.org/obo/CL_0002132	stromal cell of ovary		Any fibroblast that is part of a female gonad.
http://purl.obolibrary.org/obo/CL_2000064	ovarian surface epithelial cell	http://purl.obolibrary.org/obo/CL_0002078	meso-epithelial cell		A meso-epithelial cell of the ovarian surface epithelium, varying in shape from flat to cuboidal to pseudostratified columnar. This cell plays a crucial role in ovulation by producing proteolytic enzymes in response to gonadotropins, facilitating follicle rupture through tissue breakdown and TNF-alpha signaling. Additionally, this cell contributes to post-ovulatory wound repair (Morris et al., 2022) and exhibits stem cell-like properties (Flesken-Nikitin et al., 2013; Wang et al., 2019).
http://purl.obolibrary.org/obo/CL_2000065	ovarian microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		Any microvascular endothelial cell that is part of a female urethra.
http://purl.obolibrary.org/obo/CL_2000066	cardiac ventricle fibroblast	http://purl.obolibrary.org/obo/CL_0002548	fibroblast of cardiac tissue		Any fibroblast that is part of a cardiac ventricle.
http://purl.obolibrary.org/obo/CL_2000067	cardiac atrium fibroblast	http://purl.obolibrary.org/obo/CL_0002548	fibroblast of cardiac tissue		Any fibroblast that is part of a cardiac atrium.
http://purl.obolibrary.org/obo/CL_2000068	pericardium fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		Any fibroblast that is part of a pericardium.
http://purl.obolibrary.org/obo/CL_2000069	gallbladder fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		Any fibroblast that is part of a gallbladder.
http://purl.obolibrary.org/obo/CL_2000070	optic choroid fibroblast	http://purl.obolibrary.org/obo/CL_0000348	choroidal cell of the eye		Any fibroblast that is part of a optic choroid.
http://purl.obolibrary.org/obo/CL_2000071	mammary microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		Any microvascular endothelial cell that is part of a breast.
http://purl.obolibrary.org/obo/CL_2000072	adipose microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000008	microvascular endothelial cell		Any microvascular endothelial cell that is part of a adipose tissue.
http://purl.obolibrary.org/obo/CL_2000073	migratory cardiac neural crest cell	http://purl.obolibrary.org/obo/CL_0000333	migratory neural crest cell		Any migratory neural crest cell that is part of a cardiac neural crest.
http://purl.obolibrary.org/obo/CL_2000074	splenocyte	http://purl.obolibrary.org/obo/CL_0000738	leukocyte		Any leukocyte that is part of a spleen.
http://purl.obolibrary.org/obo/CL_2000076	hindlimb stylopod vein endothelial cell	http://purl.obolibrary.org/obo/CL_0002543	vein endothelial cell		Any vein endothelial cell that is part of a hindlimb stylopod.
http://purl.obolibrary.org/obo/CL_2000077	skeletal muscle tissue of pectoralis major striated muscle cell	http://purl.obolibrary.org/obo/CL_0000737	striated muscle cell		Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major.
http://purl.obolibrary.org/obo/CL_2000078	placental pericyte	http://purl.obolibrary.org/obo/CL_0000669	pericyte		Any pericyte cell that is part of a placenta.
http://purl.obolibrary.org/obo/CL_2000079	mesenchymal stem cell of femoral bone marrow	http://purl.obolibrary.org/obo/CL_0002540	mesenchymal stem cell of the bone marrow		Any mesenchymal stem cell of the bone marrow that is part of a femur.
http://purl.obolibrary.org/obo/CL_2000080	mesenchymal stem cell of abdominal adipose tissue	http://purl.obolibrary.org/obo/CL_0002570	mesenchymal stem cell of adipose tissue		Any mesenchymal stem cell of adipose tissue that is part of an abdomen.
http://purl.obolibrary.org/obo/CL_2000081	melanocyte of skin of face	http://purl.obolibrary.org/obo/CL_1000458	melanocyte of skin		Any melanocyte of skin that is part of a skin of face.
http://purl.obolibrary.org/obo/CL_2000084	conjunctiva goblet cell	http://purl.obolibrary.org/obo/CL_1000432	conjunctival epithelial cell		A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (containing MUC5AC in humans; Muc5ac/Muc5b in mice). These gel-forming mucins support tear film stability, ocular lubrication, and pathogen defence. The conjunctival goblet cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-10 in humans, claudin-2 in mice) and regulates immune homeostasis by facilitating soluble antigen transport to dendritic cells through goblet cell-associated antigen passages (GAPs) (Barbosa et al., 2017). The transcription factor SPDEF is essential for its differentiation.
http://purl.obolibrary.org/obo/CL_2000085	mononuclear cell of umbilical cord	http://purl.obolibrary.org/obo/CL_0000842	mononuclear leukocyte		Any mononuclear cell that is part of a umbilical cord.
http://purl.obolibrary.org/obo/CL_2000086	neocortex basket cell	http://purl.obolibrary.org/obo/CL_0010011	cerebral cortex GABAergic interneuron		Any basket cell that is part of a neocortex.
http://purl.obolibrary.org/obo/CL_2000088	Ammon's horn basket cell	http://purl.obolibrary.org/obo/CL_1001569	hippocampal interneuron		Any basket cell that is part of a Ammon's horn.
http://purl.obolibrary.org/obo/CL_2000091	endometrial microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_0009095	endothelial cell of uterus		Any microvascular endothelial cell that is part of a endometrial blood vessel.
http://purl.obolibrary.org/obo/CL_2000092	hair follicular keratinocyte	http://purl.obolibrary.org/obo/CL_4052061	epidermal keratinocyte		Any keratinocyte that is part of a hair follicle.
http://purl.obolibrary.org/obo/CL_2000093	bronchus fibroblast of lung	http://purl.obolibrary.org/obo/CL_0002553	fibroblast of lung		Any fibroblast of lung that is part of a bronchus.
http://purl.obolibrary.org/obo/CL_2000095	cord blood hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0002352	gestational hematopoietic stem cell		Any hematopoietic stem cell that is part of a umbilical cord blood.
http://purl.obolibrary.org/obo/UBERON_0034995	jaw mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		Mesenchyme that is part of a developing jaw [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0035034	eyelid epithelium	http://purl.obolibrary.org/obo/UBERON_0015808	eye epithelium		An epithelium that is part of an eyelid [Automatically generated definition].
http://purl.obolibrary.org/obo/UBERON_0035049	excretory duct of salivary gland	http://purl.obolibrary.org/obo/UBERON_0035050	excretory duct		Any of the interlobular excretory ducts of a salivary gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts[MP,generalized].
http://purl.obolibrary.org/obo/UBERON_0035073	duct of eccrine sweat gland	http://purl.obolibrary.org/obo/UBERON_0000058	duct		A duct made up of simple tubular epithelium that is part of an eccrine sweat gland. The main function of the duct of the eccrine sweat gland is the reabsorption of Na and Cl ions as sweat flows through the duct. It has two cell layers: basal and luminal. It is continuous with the secretory coil and goes towards the skin surface. The distal segment of the duct is relatively straight and connects with the acrosyringium in the epidermis. Most of the ion reabsorption occurs in the proximal part of the duct.
http://purl.obolibrary.org/obo/UBERON_0035267	neck of gallbladder	http://purl.obolibrary.org/obo/UBERON_0001560	neck of organ		The narrowest portion of the gallbladder and distal to the cystic duct.
http://purl.obolibrary.org/obo/UBERON_0035316	prostatic capsule	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		The membrane the surrounds the prostate gland.
http://purl.obolibrary.org/obo/UBERON_0035553	left cardiac chamber	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Any chamber of the left side of the heart.
http://purl.obolibrary.org/obo/UBERON_0035554	right cardiac chamber	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Any chamber of the right side of the heart.
http://purl.obolibrary.org/obo/UBERON_0035639	ocular adnexa	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.
http://purl.obolibrary.org/obo/UBERON_0035804	future mouth	http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube		The primordial mouth region of the developing head.
http://purl.obolibrary.org/obo/UBERON_0035805	muscle layer of sigmoid colon	http://purl.obolibrary.org/obo/UBERON_0012489	muscle layer of colon		A muscle layer that is part of the sigmoid colon.
http://purl.obolibrary.org/obo/UBERON_0035820	peritoneal sac	http://purl.obolibrary.org/obo/UBERON_0005906	serous sac		A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity.
http://purl.obolibrary.org/obo/GO_1905952	regulation of lipid localization	http://purl.obolibrary.org/obo/GO_0032879	regulation of localization		Any process that modulates the frequency, rate or extent of lipid localization.
http://purl.obolibrary.org/obo/GO_1905953	negative regulation of lipid localization	http://purl.obolibrary.org/obo/GO_1905952	regulation of lipid localization		Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization.
http://purl.obolibrary.org/obo/GO_1905954	positive regulation of lipid localization	http://purl.obolibrary.org/obo/GO_1905952	regulation of lipid localization		Any process that activates or increases the frequency, rate or extent of lipid localization.
http://purl.obolibrary.org/obo/HP_0025373	Interictal EEG abnormality	http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality		Interictal refers to a period of time between epileptic seizures. Electroencephalographic (EEG) patterns are important in the differential diagnosis of epilepsy, and the EEG is almost always abnormal during a seizure. Some persons with seizures may show EEG abnormalities between seizures, while others do not. In some cases, multiple interictal EEGs must be recorded before an abnormality is observed. In most cases the electrographic pattern of seizure onset is completely different from the activity recorded during interictal discharge.
http://purl.obolibrary.org/obo/HP_0030956	Abnormality of cardiovascular system electrophysiology	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		An anomaly of the electrical conduction physiology of the heart.
http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		A structural anomaly of the axial musculature, comprising muscles of the head and neck, muscles of the vertebral column, muscles of the thoracic wall, muscles of the abdominal wall, and muscles of the pelvic floor.
http://purl.obolibrary.org/obo/HP_0025451	Testicular adrenal rest tumor	http://purl.obolibrary.org/obo/HP_0010788	Testicular neoplasm		Testicular adrenal rest tumor (TART) is a abenign tumor of the testis. TART generally occurs multiply and bilaterally within the rete testis. Histologically, TART resemble adrenocortical tissue, which led to the name. The tumous are not encapsulated and consist of sheets or confluent cords of large polygonal cells with abundant eosinophilic cytoplasm.
http://purl.obolibrary.org/obo/HP_0025379	Anti-thyroid peroxidase antibody positivity	http://purl.obolibrary.org/obo/HP_0430050	Anti-thyroid antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid peroxidase.
http://purl.obolibrary.org/obo/HP_0025380	Increased circulating androstenedione concentration	http://purl.obolibrary.org/obo/HP_0030348	Increased circulating androgen concentration		Increased concentration of androstenedione in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025381	Anti-pituitary antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		Circulating antipituitary antibodies (APA) are markers of autoimmune hypophysitis, which may cause deficient pituitary function.
http://purl.obolibrary.org/obo/HP_0025382	Hypodipsia	http://purl.obolibrary.org/obo/HP_0030082	Abnormal drinking behavior		Reduced fluid intake (drinking) in a clinical situation where the plasma molarity or sodium concentration normally would induce greater fluid intake.
http://purl.obolibrary.org/obo/HP_0025383	Dorsocervical fat pad	http://purl.obolibrary.org/obo/HP_0001001	Abnormality of subcutaneous fat tissue		An area of fat accumulation at the back of the neck in the form of a hump.
http://purl.obolibrary.org/obo/HP_0025384	Diet-resistant subcutaneous adipose tissue	http://purl.obolibrary.org/obo/HP_0009124	Abnormal adipose tissue morphology		Areas of subcutanous fat tissue that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery.
http://purl.obolibrary.org/obo/HP_0025385	Diet-resistant subcutaneous adipose tissue below waist	http://purl.obolibrary.org/obo/HP_0025384	Diet-resistant subcutaneous adipose tissue		Areas of subcutanous fat tissue below the waist that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery.
http://purl.obolibrary.org/obo/HP_0025386	Bitemporal hollowing	http://purl.obolibrary.org/obo/HP_0000606	Abnormality of the periorbital region		Depression of profile in both temporal regions.
http://purl.obolibrary.org/obo/HP_0025387	Pill-rolling tremor	http://purl.obolibrary.org/obo/HP_0002322	Resting tremor		A type of resting tremor characterized by simultaneous rubbing movements of thumb and index fingers against each other.
http://purl.obolibrary.org/obo/HP_0025388	Thyroid nodule	http://purl.obolibrary.org/obo/HP_0011772	Abnormal thyroid morphology		A nodular lesion that develops in the thyroid gland. The term "thyroid nodule" refers to any abnormal growth that forms a lump in the thyroid gland.
http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		High-resolution computed tomography (HRCT) can distinguish findings that characterize characterize interstitial lung diseases in a way not possible with other modalities.
http://purl.obolibrary.org/obo/HP_0025390	Reticular pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		On pulmonary high-resolution computed tomography, reticular pattern is characterized by innumerable interlacing shadows suggesting a mesh.
http://purl.obolibrary.org/obo/HP_0025391	Crazy paving pattern	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		The so-called crazy paving pattern appears as thickened interlobular septa and intralobular lines superimposed on a background of ground-glass opacity, resembling irregularly shaped paving stones. The crazy-paving pattern is often sharply demarcated from more normal lung and may have a geographic outline. It was originally reported in patients with alveolar proteinosis and is also encountered in other diffuse lung diseases that affect both the interstitial and airspace compartments, such as lipoid pneumonia.
http://purl.obolibrary.org/obo/HP_0025392	Nodular pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		A nodular pattern is characterized on pulmonary high-resolution computed tomography by the presence of numerous rounded opacities that range from 2 mm to 1 cm in diameter, with micronodules defined as smaller than 3 mm in diameter.
http://purl.obolibrary.org/obo/HP_0025393	Reticulonodular pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		Co-occurrence of reticular and micronodular patterns on pulmonary high-resolution computed tomography.
http://purl.obolibrary.org/obo/HP_0025394	Cystic pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		On pulmonary high-resolution computed tomography, the cystic pattern is composed by well-defined, round and circumscribed air-containing parenchymal spaces with a well-defined wall and interface with normal lung. The wall of the cysts may be uniform or varied in thickness, but usually is thin (less than 2 mm) and occurs without associated emphysema.
http://purl.obolibrary.org/obo/HP_0025395	Combined cystic and ground-glass pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0031457	Pulmonary opacity		Co-occurrence of the cystic pattern and the ground-glass pattern on pulmonary high-resolution computed tomography,
http://purl.obolibrary.org/obo/HP_0025396	Decreased attenuation pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		Areas of low density corresponding to parenchymal destruction and reduced perfusion, and attenuation of the pulmonary vasculature, as visualized on pulmonary high-resolution computed tomography.
http://purl.obolibrary.org/obo/HP_0025397	Mosaic attenuation pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		A patchwork of intermingled areas of increased and decreased attenuation visualized on pulmonary high-resolution computed tomography.
http://purl.obolibrary.org/obo/HP_0025398	Nodular-perilymphatic pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025392	Nodular pattern on pulmonary HRCT		A nodular pattern on pulmonary high-resolution computed tomography that has a perilymphatic distribution.
http://purl.obolibrary.org/obo/HP_0025399	Nodular-centrilobular with tree-in-bud pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025392	Nodular pattern on pulmonary HRCT		A nodular pattern on pulmonary high-resolution computed tomography that displays a tree-in-bud pattern, representing centrilobular branching structures that resemble a budding tree.
http://purl.obolibrary.org/obo/HP_0025400	Nodular-random pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025392	Nodular pattern on pulmonary HRCT		A nodular pattern on pulmonary high-resolution computed tomography that has an apparently random pattern.
http://purl.obolibrary.org/obo/HP_0025401	Staring gaze	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		An abnormality in which the eyes are held permanently wide open.
http://purl.obolibrary.org/obo/HP_0025402	Square-wave jerks	http://purl.obolibrary.org/obo/HP_0032114	Saccadic intrusion		Square wave jerks are saccadic eye movements which, when recorded with open eyes are considered to be a pathological sign, caused by fixation instability, and pointing to a central neurological lesion.
http://purl.obolibrary.org/obo/HP_0025403	Stooped posture	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		A habitual positioning of the body with the head and upper back bent forward.
http://purl.obolibrary.org/obo/HP_0025404	Abnormal visual fixation	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Any anomaly in the process of ocular fixation, which is the maintaining of the visual gaze on a single location.
http://purl.obolibrary.org/obo/HP_0025405	Visual fixation instability	http://purl.obolibrary.org/obo/HP_0025404	Abnormal visual fixation		A deficit in the ability to fixate eye movements in order to stabilize images on the retina
http://purl.obolibrary.org/obo/HP_0025406	Asthenia	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.
http://purl.obolibrary.org/obo/HP_0025407	Rectourethral fistula	http://purl.obolibrary.org/obo/HP_0010480	Urethral fistula		An abnormal connection (fistula) between the rectum and the urethra.
http://purl.obolibrary.org/obo/HP_0025410	Splenogonadal fusion	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Joining of the spleen and a gonad during embryological development.
http://purl.obolibrary.org/obo/HP_0025413	Fossa navicularis urethral stricture	http://purl.obolibrary.org/obo/HP_0012227	Urethral stricture		A type of urethral stricture affecting the fossa navicularis, which is the spongy part of the male urethra located at the glans penis.
http://purl.obolibrary.org/obo/HP_0025414	Pendulous urethral stricture	http://purl.obolibrary.org/obo/HP_0012227	Urethral stricture		A type of urethral stricture affecting the pendulous urethra, which is straight and fixed to the corpora cavernosa.
http://purl.obolibrary.org/obo/HP_0025415	Bulbar urethral stricture	http://purl.obolibrary.org/obo/HP_0012227	Urethral stricture		A type of urethral stricture affecting the bulbar urethra, which is the part of the urethra that traverses the root of the penis.
http://purl.obolibrary.org/obo/HP_0025416	Vaginal stricture	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		A narrowing of the vagina owing to scar formation.
http://purl.obolibrary.org/obo/HP_0025417	Patulous urethra	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		Urethra more open or expanded than normal.
http://purl.obolibrary.org/obo/HP_0025418	Renal cortical necrosis	http://purl.obolibrary.org/obo/HP_0032618	Renal necrosis		Patchy or diffuse ischemic destruction of all the elements of renal cortex resulting from significantly diminished renal arterial perfusion. Coagulative necrosis may be present, involving all tubular segments and glomeruli. Nuclei may be pale and pyknotic, or may no longer be apparent. Thrombi may be present in vessels at the edge of the infarct.
http://purl.obolibrary.org/obo/HP_0025419	Pulmonary pneumatocele	http://purl.obolibrary.org/obo/HP_0032445	Pulmonary cyst		A pneumatocele is a thin walled, gas-filled space in the lung. It is most frequently caused by acute pneumonia, trauma, or aspiration of hydrocarbon fluid and is usually transient. The mechanism is believed to be a combination of parenchymal necrosis and check-valve airway obstruction. A pneumatocele appears as an approximately round, thin-walled airspace in the lung.
http://purl.obolibrary.org/obo/HP_0025420	Diffuse alveolar hemorrhage	http://purl.obolibrary.org/obo/HP_0040223	Pulmonary hemorrhage		A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen.
http://purl.obolibrary.org/obo/HP_0025421	Pneumomediastinum	http://purl.obolibrary.org/obo/HP_0045026	Abnormal mediastinum morphology		The presence of free air in the mediastinum.
http://purl.obolibrary.org/obo/HP_0025422	Pleural cyst	http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology		A closed sac-like structure originating from the pleura that contains a liquid, gaseous, or semisolid substance.
http://purl.obolibrary.org/obo/HP_0025425	Laryngospasm	http://purl.obolibrary.org/obo/HP_0025424	Abnormal larynx physiology		A spasm (involuntary contraction) of the vocal cords that can make it difficult to speak or breathe.
http://purl.obolibrary.org/obo/HP_0025427	Abnormal bronchus physiology	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		Any anomaly of the function of the bronchi.
http://purl.obolibrary.org/obo/HP_0025430	High-pitched cry	http://purl.obolibrary.org/obo/HP_0025429	Abnormal cry		A type of crying in an abnormally high-pitched voice.
http://purl.obolibrary.org/obo/HP_0025431	Staccato cry	http://purl.obolibrary.org/obo/HP_0025429	Abnormal cry		A type of cry that is abnormal because it is consists of unusually shortened and detached vocalizations.
http://purl.obolibrary.org/obo/HP_0025432	Acanthoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		A benign epithelial skin tumor manifesting as a slightly elevated circular plaque or nodule with a red, pink or brown color and a diameter up to 22 mm.
http://purl.obolibrary.org/obo/HP_0025433	Decreased lecithin cholesterol acyl transferase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced level of the enzyme lecithin cholesterol acyl transferase.
http://purl.obolibrary.org/obo/HP_0025434	Reduced circulating CH50 activity	http://purl.obolibrary.org/obo/HP_0031904	Abnormal total hemolytic complement activity		A diminished activity of the classical complement pathway as measured by the assay for 50% haemolytic complement (CH50) activity of serum.
http://purl.obolibrary.org/obo/HP_0025435	Increased circulating lactate dehydrogenase concentration	http://purl.obolibrary.org/obo/HP_0045040	Abnormal circulating lactate dehydrogenase concentration		An elevated level of the enzyme lactate dehydrogenase in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025436	Elevated serum 11-deoxycortisol	http://purl.obolibrary.org/obo/HP_0003118	Increased circulating cortisol level		Increased concentration of 11-deoxycortisol in the circulation. 11-deoxycorticosterone, which is also known as simply deoxycorticosterone and 21-hydroxyprogesterone, is a steroid hormore that is produces in the adrenals and is a precursor to aldosterone.
http://purl.obolibrary.org/obo/HP_0025437	Macrozoospermia	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Increased size of the head of sperm.
http://purl.obolibrary.org/obo/HP_0025439	Pharyngitis	http://purl.obolibrary.org/obo/HP_0033151	Abnormal pharynx morphology		Inflammation (due to infection or irritation) of the pharynx.
http://purl.obolibrary.org/obo/HP_0025440	Warm reactive autoantibody positivity	http://purl.obolibrary.org/obo/HP_6000388	Anti-erythrocyte autoantibody positivity		Warm reactive autoantibodies are RBC-directed immune responses that are maximally reactive at 37 degrees C.
http://purl.obolibrary.org/obo/HP_0025441	Achilles tendon calcification	http://purl.obolibrary.org/obo/HP_0005109	Abnormal Achilles tendon morphology		Ectopic deposition of calcium salts in the Achilles tendon.
http://purl.obolibrary.org/obo/HP_0025443	Abnormal cardiac atrial physiology	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		An abnormality of the function of the cardiac atria.
http://purl.obolibrary.org/obo/HP_0025444	Reduced amygdala volume	http://purl.obolibrary.org/obo/HP_0033668	Abnormal amygdala morphology		A decrease in the volume (size) of the amygdyla.
http://purl.obolibrary.org/obo/HP_0025445	Abnormal papillary muscle morphology	http://purl.obolibrary.org/obo/HP_0001711	Abnormal left ventricle morphology		Any structural anomaly of the papillary muscles of the left ventricle.
http://purl.obolibrary.org/obo/HP_0025446	Anomalous insertion of papillary muscle directly into anterior mitral leaflet	http://purl.obolibrary.org/obo/HP_0025445	Abnormal papillary muscle morphology		A congenital malformation in which one or both of the papillary muscles (posteromedial or anterolateral) insert directly (that is, without interpositioned chordae tendineae) into the anterior mitral leaflet.
http://purl.obolibrary.org/obo/HP_0025447	Displacement of the papillary muscles	http://purl.obolibrary.org/obo/HP_0025445	Abnormal papillary muscle morphology		Abnormal location of the insertion of a papillary muscle into the left ventricular wall.
http://purl.obolibrary.org/obo/HP_0025448	Anterior displacement of the papillary muscles	http://purl.obolibrary.org/obo/HP_0025447	Displacement of the papillary muscles		Abnormally anterior location of the papillary muscles of the left ventricle.
http://purl.obolibrary.org/obo/HP_0025449	Apically displaced anterolateral papillary muscle	http://purl.obolibrary.org/obo/HP_0025447	Displacement of the papillary muscles		Abnormal location of the insertion of the anterolateral papillary muscle near to the apex of the left ventricle. This feature may be appreciated by noting that this muscle is usually not seen in the apical level of the parasternal short-axis echocardiographic view,
http://purl.obolibrary.org/obo/HP_0025452	Pyoderma gangrenosum	http://purl.obolibrary.org/obo/HP_0200042	Skin ulcer		A deep skin ulcer with a well defined border, which is usually violet or blue. The ulcer edge is often undermined (worn and damaged) and the surrounding skin is erythematous and indurated. The ulcer often starts as a small papule or collection of papules, which break down to form small ulcers with a so called cat's paw appearance. These coalesce and the central area then undergoes necrosis to form a single ulcer.
http://purl.obolibrary.org/obo/HP_0025453	Delayed adrenarche	http://purl.obolibrary.org/obo/HP_0000823	Delayed puberty		Occurrence of adrenarche at a later than normal age. Adrenarche normally occurs between six and eight years of age with increased adrenal androgen secretion; its exact biologic role is not well understood. It is accompanied by changes in pilosebaceous units, a transient growth spurt and the appearance of axillary and pubic hair in some children, but no sexual development.
http://purl.obolibrary.org/obo/HP_0025455	Decreased CSF 5-hydroxyindolacetic acid concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		5-HIAA (5-hydroxyindolacetic acid) concentration in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025457	Decreased CSF protein concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		CSF total protein level is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025458	Decreased CSF albumin concentration	http://purl.obolibrary.org/obo/HP_0500238	Abnormal CSF albumin concentration		CSF albumin level is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025459	Increased CSF/serum albumin ratio	http://purl.obolibrary.org/obo/HP_0030981	Abnormal CSF/serum albumin ratio		An increase above normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration.
http://purl.obolibrary.org/obo/HP_0025460	High myoinositol in brain by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An elevated level of myoinositol in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology	http://purl.obolibrary.org/obo/HP_0025354	Abnormal cellular phenotype		Any anomaly of cell structure.
http://purl.obolibrary.org/obo/HP_0025463	Abnormality of redox activity	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		An abnormality of the processes that maintain the redox environment of a cell or compartment within a cell, that is, the balance between reduction and oxidation chemical reactions.
http://purl.obolibrary.org/obo/HP_0025464	Increased reactive oxygen species production	http://purl.obolibrary.org/obo/HP_0025463	Abnormality of redox activity		An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage.
http://purl.obolibrary.org/obo/HP_0025465	Abnormal circulating beta globulin concentration	http://purl.obolibrary.org/obo/HP_0032179	Abnormal circulating globulin concentration		Any deviation from the normal concentration of beta globulin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025466	Beta 2-microglobulinuria	http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level		Increased level of beta 2-microglobulins in the urine.
http://purl.obolibrary.org/obo/HP_0025469	Anagen effluvium	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		An abnormal loss of anagen (growth phase) hairs.
http://purl.obolibrary.org/obo/HP_0025470	Telogen effluvium	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		A type of hair loss characterized by an abnormal increase in dormant, telogen stage hair follicles.
http://purl.obolibrary.org/obo/HP_0025471	Congenital panfollicular nevus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		A hamartomatous proliferation containing malformed hair follicles in various stages of development. Panfolliculomas are well-circumscribed lesions demonstrating all stages of follicular differentiation.
http://purl.obolibrary.org/obo/HP_0025472	Recurrent plantar mycosis	http://purl.obolibrary.org/obo/HP_0002841	Recurrent fungal infections		A history of repeated fungal infections located on the sole of the foot, usually manifested by scaling, maceration, and itching.
http://purl.obolibrary.org/obo/HP_0025473	Hyperpigmented papule	http://purl.obolibrary.org/obo/HP_0200034	Papule		A papule (circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point) that exhibits increased pigmentation (is darker) compared to the surrounding skin.
http://purl.obolibrary.org/obo/HP_0025474	Erythematous plaque	http://purl.obolibrary.org/obo/HP_0200035	Skin plaque		A plaque (a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter) with a red or reddish color often associated with inflammation or irritation.
http://purl.obolibrary.org/obo/HP_0025475	Erythematous macule	http://purl.obolibrary.org/obo/HP_0012733	Macule		A macule (flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin) with a red or reddish color often associated with inflammation or irritation.
http://purl.obolibrary.org/obo/HP_0025476	Testicular lipomatosis	http://purl.obolibrary.org/obo/HP_0001012	Multiple lipomas		Multiple foci of adipocytes within the testicular interstitium, usually presenting as multiple bilateral ill-defined hyperechoic intratesticular lesions of different sizes but generally with maximum diameter of 4 mm.
http://purl.obolibrary.org/obo/HP_0025477	Periarticular calcification	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		Calcified deposits in soft tissue structures outside a joint.
http://purl.obolibrary.org/obo/HP_0025478	Atrial standstill	http://purl.obolibrary.org/obo/HP_0005115	Supraventricular arrhythmia		Atrial standstill or silent atrium is a rare condition presenting with the absence of electrical and mechanical activity in the atria. It presents with the absence of P waves, bradycardia, and wide QRS complex in the electrocardiogram.
http://purl.obolibrary.org/obo/HP_0025479	Self-neglect	http://purl.obolibrary.org/obo/HP_0000745	Abnormal diminished volition		A pathological neglect of personal needs and well-being that includes attending to self-grooming, personal care and the attention to cleanliness of personal space.
http://purl.obolibrary.org/obo/HP_0025480	Lipomyelomeningocele	http://purl.obolibrary.org/obo/HP_0034238	Closed neural tube defect		A type of spinal dysraphism presenting as a subcutaneous fatty mass, that is, a spinal defect associated with lipomatous tissue, and covered by skin. The most usual location for lipomyelomeningocele is at the gluteal cleft.
http://purl.obolibrary.org/obo/HP_0025481	Cervical hemivertebrae	http://purl.obolibrary.org/obo/HP_0002937	Hemivertebrae		Absence of one half of the vertebral body in the cervical spine.
http://purl.obolibrary.org/obo/HP_0025482	Positive perchlorate discharge test	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		An abnormal result of the perchlorate discharge test. In this test, first radioactive iodine is administered, sufficient time is allowed to pass so that the radioactive iodine is captured by the thyroid,and then, perchlorate is administered orally. The perchlorate displaces non-organified iodide from the thyroid. The perchlorate discharge test is considered positive (abnormal) if there is an abnormally rapid loss of radioactive iodine from the thyroid.
http://purl.obolibrary.org/obo/HP_0025483	Abnormal circulating thyroglobulin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of thyroglobulin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025484	Elevated circulating thyroglobulin concentration	http://purl.obolibrary.org/obo/HP_0025483	Abnormal circulating thyroglobulin concentration		The concentration of thyroglobulin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0025485	Vaginal adenosis	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, thought to be derived from persistent Müllerian (synonymous with paramesonephric) epithelium islets in postembryonic life.
http://purl.obolibrary.org/obo/HP_0025486	Fused labia majora	http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology		The outer labia are sealed together.
http://purl.obolibrary.org/obo/HP_0025488	Detrusor sphincter dyssynergia	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		A urodynamic anomaly characterized by bladder outlet obstruction from detrusor muscle contraction with concomitant involuntary urethral sphincter activation.
http://purl.obolibrary.org/obo/HP_0025489	Bladder duplication	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		A congenital anomaly characterized by the presence of two bladders.
http://purl.obolibrary.org/obo/HP_0025490	Myocardial bridging	http://purl.obolibrary.org/obo/HP_0011686	Abnormal coronary artery course		A congenital variant of a coronary artery in which a portion of an epicardial coronary artery (most frequently the middle segment of the left anterior descending artery) takes an intramuscular course.
http://purl.obolibrary.org/obo/HP_0025491	Venous stenosis	http://purl.obolibrary.org/obo/HP_0002624	Abnormal venous morphology		Narrowing of a vein due to intimal hyperplasia and fibrosis.
http://purl.obolibrary.org/obo/HP_0025492	Microcoria	http://purl.obolibrary.org/obo/HP_0007700	Ocular anterior segment dysgenesis		A small pupil (typically diameter less than 2 mm) that dilates poorly or not at all in response to topically administered mydriatic drugs.
http://purl.obolibrary.org/obo/HP_0025493	Palmoplantar erythema	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Redness of the skin of the palm of the hand and the sole of the foot caused by hyperemia of the capillaries in the lower layers of the skin.
http://purl.obolibrary.org/obo/HP_0025494	Coated aorta	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Regular circumferential periaortic fibrosis involving the whole aorta and leading to a coated aorta appearance on computed tomography scans
http://purl.obolibrary.org/obo/HP_0025495	Descending aorta hypoplasia	http://purl.obolibrary.org/obo/HP_0031934	Abnormal descending aorta morphology		Significant luminal narrowing of a long segment of the descending aorta.
http://purl.obolibrary.org/obo/HP_0025496	Abnormal coronary artery physiology	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Any anomaly of the function of a coronary artery.
http://purl.obolibrary.org/obo/HP_0025497	Coronary artery spasm	http://purl.obolibrary.org/obo/HP_0025496	Abnormal coronary artery physiology		A brief and sudden narrowing of a coronary artery.
http://purl.obolibrary.org/obo/HP_0025498	Aceruloplasminemia	http://purl.obolibrary.org/obo/HP_0033144	Abnormal circulating ceruloplasmin concentration		Absence of ceruloplasmin in the blood.
http://purl.obolibrary.org/obo/HP_0025499	Class I obesity	http://purl.obolibrary.org/obo/HP_0001513	Obesity		Obesity with a body mass index of 30 to 34.9 kg per square meter.
http://purl.obolibrary.org/obo/HP_0025500	Class II obesity	http://purl.obolibrary.org/obo/HP_0001513	Obesity		Obesity with a body mass index of 35 to 39.9 kg per square meter.
http://purl.obolibrary.org/obo/HP_0025501	Class III obesity	http://purl.obolibrary.org/obo/HP_0001513	Obesity		Obesity with a body mass index of 40 kg per square meter or higher.
http://purl.obolibrary.org/obo/HP_0025502	Overweight	http://purl.obolibrary.org/obo/HP_0004324	Increased body weight		Increased body weight with a body mass index of 25-29.9 kg per square meter.
http://purl.obolibrary.org/obo/HP_0025503	Anomalous coronary artery arising from the opposite sinus	http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin		Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva.
http://purl.obolibrary.org/obo/HP_0025505	Anomalous origin of the circumflex artery from the right sinus of Valsalva	http://purl.obolibrary.org/obo/HP_0011636	Abnormal coronary artery origin		The circumflex coronary artery originates from the right aortic sinus of Valsalva.
http://purl.obolibrary.org/obo/HP_0025506	Coronary artery sandwich anomaly	http://purl.obolibrary.org/obo/HP_0025503	Anomalous coronary artery arising from the opposite sinus		Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva, with the additional feature that the artery passes between the two great arteries. This carries a risk of the artery being compressed by these two vessels,
http://purl.obolibrary.org/obo/HP_0025507	Yellow papule	http://purl.obolibrary.org/obo/HP_0200034	Papule		A papule with yellow color.
http://purl.obolibrary.org/obo/HP_0025508	Gottron's papules	http://purl.obolibrary.org/obo/HP_0200034	Papule		Violaceous papules overlying the dorsal and lateral aspects of the metacarpophalangeal and proximal interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0025509	Piezogenic pedal papules	http://purl.obolibrary.org/obo/HP_0200034	Papule		Flesh-colored or yellowish papules, 2 mm or larger, that are responses to internal mechanical pressure and weakness in the connective tissue in the dermis, appear commonly over the medial aspect of the heel, but in some cases on the wrists. They are thought to represent herniations of adipose tissue through the plantar fascia retinaculum.
http://purl.obolibrary.org/obo/HP_0025510	Nevus spilus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		A tan, regularly bordered patch with darker macules within the lesion.
http://purl.obolibrary.org/obo/HP_0025511	Nevus sebaceus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		A solitary yellow-orange slightly raised plaque typically on scalp or face. The plaque typically thickens and becomes more verrucous or pebbly during childhood.
http://purl.obolibrary.org/obo/HP_0025512	Skin-colored papule	http://purl.obolibrary.org/obo/HP_0200034	Papule		A papule with the same color as the surrounding skin.
http://purl.obolibrary.org/obo/HP_0025513	Scleral rupture	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		Breakage of the sclera.
http://purl.obolibrary.org/obo/HP_0025514	Morning glory anomaly	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		An abnormality of the optic nerve in which the optic nerve is large and funneled and displays a conical excavation of the optic disc. The optic disc appears dysplastic.
http://purl.obolibrary.org/obo/HP_0025515	Delayed thelarche	http://purl.obolibrary.org/obo/HP_0000823	Delayed puberty		Later than normal development of the breasts.
http://purl.obolibrary.org/obo/HP_0025516	Coronary-pulmonary artery fistula	http://purl.obolibrary.org/obo/HP_0011641	Coronary artery fistula		A congenital malformation with abnormal connection between one of the coronary arteries and the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0025517	Hypoplastic hippocampus	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		Underdevelopment of the hippocampus.
http://purl.obolibrary.org/obo/HP_0025518	Visual gaze preference	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		An abnormality of gaze that can be observed following an acute supranuclear cerebral lesion (e.g., stroke) that is characterized by an acute inability to direct gaze contralateral to the side of the lesion and is accompanied by a tendency for tonic deviation of the eyes toward the side of the lesion.
http://purl.obolibrary.org/obo/HP_0025519	Multiple biliary hamartomas	http://purl.obolibrary.org/obo/HP_0100574	Biliary tract neoplasm		Multiple biliary hamartomas are a rare clinicopathologic entity, consisting of small (less than 1.5cm), usually multiple and nodular cystic lesions in the liver.
http://purl.obolibrary.org/obo/HP_0025520	Calcinosis cutis	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		Deposition of calcium in the skin.
http://purl.obolibrary.org/obo/HP_0025521	Increased body fat percentage	http://purl.obolibrary.org/obo/HP_0001507	Growth abnormality		The percentage of fat as a part of total body weight above the norm, usually defined as 32% for females and 25% for males.
http://purl.obolibrary.org/obo/HP_0025522	Elongated chordae tendinae of the mitral valve	http://purl.obolibrary.org/obo/HP_0025523	Abnormal morphology of the chordae tendinae of the mitral valve		Abnormal increased in length of the chordae tendinae of the mitral valve.
http://purl.obolibrary.org/obo/HP_0025524	Palmoplantar scaling skin	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		Loss of the outer layer of the epidermis in large, scale-like flakes localized to the palm of the hand and the sole of the foot.
http://purl.obolibrary.org/obo/HP_0025525	Scaling skin on fingertip	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		Loss of the outer layer of the epidermis in large, scale-like flakes localized to one or more fingertips.
http://purl.obolibrary.org/obo/HP_0025526	Psoriasiform lesion	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		A skin lesions that resembles the lesions observed in psoriasis, viz., an erythematous plaque covered by fine silvery scales. Psoriasiform lesions can be observed in psoriasis as well as in other conditions including allergic contact dermatitis, seborrhoeic dermatitis, Atopic dermatitis, pityriasis rubra, and lichen simplex chronicus.
http://purl.obolibrary.org/obo/HP_0025527	Serpiginous cutaneous lesion	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A skin lesion with a snake- or serpent-like distribution.
http://purl.obolibrary.org/obo/HP_0025528	Annular cutaneous lesion	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A lesion of the skin with a ring-like distribution.
http://purl.obolibrary.org/obo/HP_0025529	Hyperpigmented nodule	http://purl.obolibrary.org/obo/HP_0200036	Skin nodule		A nodule of the skin that exhibits an increased amount of pigmentation.
http://purl.obolibrary.org/obo/HP_0025530	Xanthomas of the palmar creases	http://purl.obolibrary.org/obo/HP_0000991	Xanthomatosis		The presence of multiple xanthomas (xanthomata) in the skin distributed in the creases of the palm of the hand. Xanthomas are yellowish, firm, lipid-laden nodules in the skin.
http://purl.obolibrary.org/obo/HP_0025531	Harlequin phenomenon	http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology		The Harlequin phenomenon consists of a sudden change in skin color, resulting in two different body colors, one on each half of the body.
http://purl.obolibrary.org/obo/HP_0025532	Positive pathergy test	http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology		With the pathergy test, a small, sterile needle is inserted into the skin of the forearm. The site of injectionis circuled and observed after one and two days. If a small red bump or pustule at the site of needle insertion occurs, the pathergy test is considered to have a positive (abnormal) result.
http://purl.obolibrary.org/obo/HP_0025534	Ocular melanocytosis	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		A congenital lesion of the sclera characterized by unilateral patchy but extensive slate-gray or bluish discoloration of the sclera . The conjunctiva are spared.
http://purl.obolibrary.org/obo/HP_0025535	Shawl sign	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Erythematous, poikilodermatous macules distributed in a shawl pattern over the shoulders, arms and upper back.
http://purl.obolibrary.org/obo/HP_0025536	V-sign	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Erythematous, poikilodermatous macules distributed in a V-shaped distribution over the anterior neck and chest.
http://purl.obolibrary.org/obo/HP_0025537	Plantar edema	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		An abnormal accumulation of fluid beneath the skin on sole of the foot.
http://purl.obolibrary.org/obo/HP_0025538	Palmar edema	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		An abnormal accumulation of fluid beneath the skin on the palm of the hand.
http://purl.obolibrary.org/obo/HP_0025539	Abnormal B cell subset distribution	http://purl.obolibrary.org/obo/HP_0002846	Abnormal B cell morphology		Abnormal increase or decrease of any B cell subpopulation, measured as percentage of total CD19+ or CD20+ B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number	http://purl.obolibrary.org/obo/HP_0002843	Abnormal T cell morphology		Abnormal increase or decrease of absolute number (either count per volume or percentage of total lymphocytes) of any T cell subpopulation, commonly characterized as CD3+ lymphocytes, in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0030961	Microspherophakia	http://purl.obolibrary.org/obo/HP_0034375	Spherophakia		Microspherophakia is a rare congenital anomaly characterized by the abnormal spherical shape of the crystalline lens. It is characterized by an increased anteroposterior thickness of the lens associated with reduced equatorial diameter. The primary pathology lies in the development of zonules. The condition is often bilateral and is characterized by small, thick, and spherical lenses.
http://purl.obolibrary.org/obo/HP_0030965	Aortic stiffness	http://purl.obolibrary.org/obo/HP_0030964	Abnormal aortic physiology		The elastic properties of the aorta allow the aorta to store half of the cardiac ejected blood volume per beat, whereby aortic recoil during diastole pushes the remaining stored volume forward into the peripheral circulation, a phenomenon known as the Windkessel function. Aortic stiffness occurs as the elastic fibers within the arterial wall become disrupted due to mechanical stress (with age or due to other factors). Aortic stiffness refers to a reduction in the elasticity of the aorta, which is associated with an elevated pulse pressure, increased wave reflection, and often hypertension.
http://purl.obolibrary.org/obo/HP_0030969	Abnormal pulmonary vein physiology	http://purl.obolibrary.org/obo/HP_0011718	Abnormality of the pulmonary veins		An abnormality of the function of the pulmonary veins.
http://purl.obolibrary.org/obo/HP_0030970	Abnormal vena cava physiology	http://purl.obolibrary.org/obo/HP_0030846	Abnormality of venous physiology		An abnormality of the function of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava.
http://purl.obolibrary.org/obo/HP_0030973	Postexertional symptom exacerbation	http://purl.obolibrary.org/obo/HP_0003546	Exercise intolerance		Post-exertional symptom exacerbation (PESE), also referred to as post-exertional malaise (PEM), is defined as the worsening of symptoms that can follow minimal cognitive, physical, emotional, or social activity, or activity that could previously be tolerated. Symptoms typically worsen 12 to 72 hours after activity and can last for days or even weeks, sometimes leading to a relapse.
http://purl.obolibrary.org/obo/HP_0030974	Cryptozoospermia	http://purl.obolibrary.org/obo/HP_0000798	Oligozoospermia		A type of oligozoospermia in which spermatozoa can be detected in an ejaculate only after centrifugation and inspection of the pellet.
http://purl.obolibrary.org/obo/HP_0030975	Pontine tegmental cap	http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology		An abnormal curved or vaulted (capped) structure covering the middle third of the dorsal pontine tegmentum and projecting into the fourth ventricle.
http://purl.obolibrary.org/obo/HP_0030977	Increased factor VIII activity	http://purl.obolibrary.org/obo/HP_0030976	Abnormal factor VIII activity		Increased activity of the coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X.
http://purl.obolibrary.org/obo/HP_0030978	Decreased CSF/serum albumin ratio	http://purl.obolibrary.org/obo/HP_0030981	Abnormal CSF/serum albumin ratio		A reduction below normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration.
http://purl.obolibrary.org/obo/HP_0030979	Dilatation of large choroidal vessels	http://purl.obolibrary.org/obo/HP_0000610	Abnormal choroid morphology		Enlargement of the large blood vessels in the choroid.
http://purl.obolibrary.org/obo/HP_0030980	Reduced brain glutamine level by MRS	http://purl.obolibrary.org/obo/HP_0034496	Abnormal brain glutamine level by MRS		An decrease in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0030981	Abnormal CSF/serum albumin ratio	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		A deviation from the normal range of the ratio of the albumin concentration in the cerebrospinal fluid (CSF) to the concentration in serum (which may be defined as 3.2-9.0). This is an index of blood-brain barrier (BBB) integrity, adjusted for the serum albumin concentration, and an increased ratio is taken as a sign of a loss of integrity of the BBB with leakage of albumin into the CSF.
http://purl.obolibrary.org/obo/HP_0030983	Ovarian thecoma	http://purl.obolibrary.org/obo/HP_0031918	Ovarian sex cord-stromal tumor		A sex cord-stromal tumor of the ovary. Thecomas range from small tumors to large solid or solid-cystic masses of up to 15 cm. They are unilateral in over 90 percent of cases and are rarely malignant. Thecomas are stromal tumors made up of cells that resemble theca cells, lutein cells and fibroblasts. They are traditionally classified within the sex cord-stromal tumor category of ovarian tumor types.
http://purl.obolibrary.org/obo/HP_0030984	Abnormal serum bile acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		A deviation from the normal concentration of serum bile acid concentration.
http://purl.obolibrary.org/obo/HP_0030985	Decreased serum bile acid concentration	http://purl.obolibrary.org/obo/HP_0030984	Abnormal serum bile acid concentration		A reduction in the concentration of bile acid in the blood.
http://purl.obolibrary.org/obo/HP_0030986	Biliary epithelial hyperplasia	http://purl.obolibrary.org/obo/HP_0012440	Abnormal biliary tract morphology		Hyperplasia of lining epithelia of the septal and large bile ducts manifesting as micropapillary projections or as a stratification of the epithelium with or without dilatation of the duct lumen.
http://purl.obolibrary.org/obo/HP_0030987	Suppurative cholangitis	http://purl.obolibrary.org/obo/HP_0030151	Cholangitis		Cholangitis characterized by the presence of numerous polymorphonuclear cells around and within the wall as well as within the lumen of the ducts. This may involve ducts of any size and is occasionally associated with abscess formation (cholangitic abscess).
http://purl.obolibrary.org/obo/HP_0030988	Granulomatous cholangitis	http://purl.obolibrary.org/obo/HP_0030151	Cholangitis		Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts.
http://purl.obolibrary.org/obo/HP_0030989	Lymphoid cholangitis	http://purl.obolibrary.org/obo/HP_0030151	Cholangitis		Cholangitis characterized by a close association between duct branches, usually interlobular bile ducts, and lymphocytic aggregates, which may show a follicular arrangement.
http://purl.obolibrary.org/obo/HP_0030990	Pleomorphic cholangitis	http://purl.obolibrary.org/obo/HP_0030151	Cholangitis		Cholangitis associated with mixed inflammatory infiltrates and the presence of fibrosis or sclerosis of the biliary tree.
http://purl.obolibrary.org/obo/HP_0030991	Sclerosing cholangitis	http://purl.obolibrary.org/obo/HP_0030151	Cholangitis		Cholangitis associated with evident ductal fibrosis that develops as a consequence of long-standing bile duct inflammatory, obstruction, or ischemic injury; it can be obliterative or nonobliterative.
http://purl.obolibrary.org/obo/HP_0030992	Abnormal pancreatic duct morphology	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Any structural anomaly of the pancreatic duct, which is the tubular structure that collects exocrine pancreatic secretions and transports them to the duodenum.
http://purl.obolibrary.org/obo/HP_0030993	Duplication of pancreatic duct	http://purl.obolibrary.org/obo/HP_0030992	Abnormal pancreatic duct morphology		A congenital anomaly characterized by the presence of two separate pancreatic ducts.
http://purl.obolibrary.org/obo/HP_0030994	Pancreas divisum	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		A congenital anomaly of the pancreas that results from failed fusion of the dorsal and ventral ducts during embyological development. Three variants have been described: type 1 or classical divisum in which there is total failure of fusion; type 2 in which dorsal drainage is dominant in the absence of the duct of Wirsung; and type 3 or incomplete divisum where a small communicating branch is present.
http://purl.obolibrary.org/obo/HP_0030996	Megaduodenum	http://purl.obolibrary.org/obo/HP_0002246	Abnormal duodenum morphology		Dilation and elongation of the duodenum with hypertrophy of all layers of the duodenum.
http://purl.obolibrary.org/obo/HP_0030997	Atretic vas deferens	http://purl.obolibrary.org/obo/HP_0012872	Abnormal vas deferens morphology		Abnormal closure or blockage of the vas deferens.
http://purl.obolibrary.org/obo/HP_0030998	Cerebrospinal fluid rhinorrhoea	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		Drainage of cerebrospinal fluid through the nose. This can occur when there is a fistula between the dura and the skull base and discharge of cerebrospinal fluid (CSF) from the nose.
http://purl.obolibrary.org/obo/HP_0030999	Abnormal vestibular saccule morphology	http://purl.obolibrary.org/obo/HP_0011376	Abnormal morphology of the vestibule of the inner ear		Any structural anomaly of the saccule of the vestibule. The saccule is the otolith organ that senses motions in the sagittal plane (i.e., up-down movement).
http://purl.obolibrary.org/obo/HP_0031000	Vestibular saccular degeneration	http://purl.obolibrary.org/obo/HP_0030999	Abnormal vestibular saccule morphology		Deterioration or loss of the tissues of the saccule of the vestibule.
http://purl.obolibrary.org/obo/HP_0031001	Minifascicle formation	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		A nerve fascicle or fasciculus is a small bundle of axons, enclosed by the perineurium. A minifascule refers to a group of thinly myelinated and unmyelinated axons surrounded by a delicate perineurium, and with a smaller diameter than a normal nerve fascicle.
http://purl.obolibrary.org/obo/HP_0031002	Neuritis	http://purl.obolibrary.org/obo/HP_0000759	Abnormal peripheral nervous system morphology		Inflammation of a nerve.
http://purl.obolibrary.org/obo/HP_0031003	Polyneuritis	http://purl.obolibrary.org/obo/HP_0031002	Neuritis		Simultaneous inflammation of multiple nerves.
http://purl.obolibrary.org/obo/HP_0031004	Hemiareflexia	http://purl.obolibrary.org/obo/HP_0001284	Areflexia		Areflexia that is limited to one side of the body.
http://purl.obolibrary.org/obo/HP_0031006	Acroparesthesia	http://purl.obolibrary.org/obo/HP_0003401	Paresthesia		A type of paresthesia (tingling, pins-and-needles, burning or numbness or stiffness) that occurs in the hands and feet and particularly in the fingers and toes.
http://purl.obolibrary.org/obo/HP_0031008	Lingual dystonia	http://purl.obolibrary.org/obo/HP_0012179	Craniofacial dystonia		Involuntary protrusions, movements, spams and contortions of the tongue.
http://purl.obolibrary.org/obo/HP_0031009	Ainhum	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Development of a fibrotic constriction ring involving the base of one or more toes, conditioning eversion and absorption of distal structures, possibly progressing to spontaneous amputation.
http://purl.obolibrary.org/obo/HP_0031010	Hyperphalangy of the 3rd finger	http://purl.obolibrary.org/obo/HP_0030367	Finger hyperphalangy		An accessory phalanx of the third (middle) finger that is arranged linearly with the other phalanges. Hyperphalangy results from an accessory ossification center at the metacarpophalangeal joint.
http://purl.obolibrary.org/obo/HP_0031011	Fatty streak	http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis		Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV.
http://purl.obolibrary.org/obo/HP_0031012	Thin-cap fibroatheroma	http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis		Thin-cap fibroatheroma is characterized by a relatively large necrotic core with an overlying thin fibrous cap measuring less than 65 micrometers and typically containing numerous macrophages, and is considered to be the precursor lesion of plaque rupture which is the most common cause of coronary thrombosis.
http://purl.obolibrary.org/obo/HP_0031015	Intrahepatic portal vein sclerosis	http://purl.obolibrary.org/obo/HP_0031941	Abnormal portal venous system morphology		Sclerosis of the intrahepatic portal veins of the liver and generally accompanied by non-cirrhotic portal hypertension, features of which may include splenomegaly and varices.
http://purl.obolibrary.org/obo/HP_0031016	Alternating radiolucent and radiodense metaphyseal lines	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Areas of radio-opaque sclerotic bands alternating with those of normal lucency give rise to stripes akin to a zebra.
http://purl.obolibrary.org/obo/HP_0031017	Swiss cheese atrial septal defect	http://purl.obolibrary.org/obo/HP_0001631	Atrial septal defect		Multiple defects in the atrial septum.
http://purl.obolibrary.org/obo/HP_0031018	Eccrine syringofibroadenoma	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		Eccrine syringofibroadenoma (ESFA) is a benign adnexal tumor arising most often on the extremities of elderly individuals characterized by anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells and ductal structures. ESFA stains positively with epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA).
http://purl.obolibrary.org/obo/HP_0031019	Pyknotic bone marrow neutrophils	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		Nuclear lobes of neutrophils in the bone marrow are thickened and condensed, and individual lobes are connected by unusually long chromatin filaments.
http://purl.obolibrary.org/obo/HP_0031020	Bone marrow hypercellularity	http://purl.obolibrary.org/obo/HP_0012145	Abnormality of multiple cell lineages in the bone marrow		A larger than normal amount or percentage of hematopoietic cells relative to marrow fat.
http://purl.obolibrary.org/obo/HP_0031021	Squamous Papilloma	http://purl.obolibrary.org/obo/HP_0012740	Papilloma		A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy [NCI thesaurus].
http://purl.obolibrary.org/obo/HP_0031022	Oropharyngeal squamous papilloma	http://purl.obolibrary.org/obo/HP_0031021	Squamous Papilloma		A benign exophytic neoplasm that arises from the oropharynx. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium [NCI thesaurus].
http://purl.obolibrary.org/obo/HP_0031023	Multiple mucosal neuromas	http://purl.obolibrary.org/obo/HP_0030430	Neuroma		Multiple painful, dome-shaped, translucent pink to skin-colored papules on oral mucosa. Histologically, the lesions may demonstrate dermal proliferation of well-demarcated nerve bundles associated with abundant mucin and surrounded by a distinct perineural sheath.
http://purl.obolibrary.org/obo/HP_0031024	Cylindroma	http://purl.obolibrary.org/obo/HP_0012842	Skin appendage neoplasm		A benign skin adnexal tumor of eccrine differentiation.
http://purl.obolibrary.org/obo/HP_0031025	Gastric leiomyosarcoma	http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach		A malignant neoplasm of the stomach that grows submucosally in the gastric wall. Necrosis and hemorrhage may be visible radiologically. Histologically, spindle cells with abnormal mitotic activity may be visible.
http://purl.obolibrary.org/obo/HP_0031026	Snail-like ilia	http://purl.obolibrary.org/obo/HP_0002867	Abnormal ilium morphology		The ilia is round and hypoplastic with a very flat acetabular roof and a very unusual medial projection of bone that is said to resemble the head of a snail. Figure 4 of PMID:3799723 illustrates this feature.
http://purl.obolibrary.org/obo/HP_0031027	Internal notch of the femoral head	http://purl.obolibrary.org/obo/HP_0003368	Abnormal femoral head morphology		A small V-shaped indentation on the internal aspect of the femoral head. This feature is well illustrated in Figure 5 of PMID:11694546.
http://purl.obolibrary.org/obo/HP_0031028	Lactescent serum	http://purl.obolibrary.org/obo/HP_0002155	Hypertriglyceridemia		Serum sample with a grossly white (milk-like, i.e., lactescent) appearance. This feature is indicative of an extremely elevated serum triglyceride level.
http://purl.obolibrary.org/obo/HP_0031029	Elevated circulating CEA concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of CEA (carcinoembryonic antigen) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031030	Elevated circulating mucin 16 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of mucin-16 (also known as CA-125) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031031	Abnormal circulating retinol-binding protein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of retinol-binding protein in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031032	Decreased circulating retinol-binding protein concentration	http://purl.obolibrary.org/obo/HP_0031031	Abnormal circulating retinol-binding protein concentration		The concentration of retinol-binding protein in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031033	Impaired urinary acidification	http://purl.obolibrary.org/obo/HP_0012211	Abnormal renal physiology		The kidney contributes towards acid-base homeostasis by excreting H+ ions and retaining bicarbonate. This process is known as acidification of the urine. The pH of urine ranges normally from 4.5 to 8. The inability to reduce the pH of the urine in a situation where it would be otherwise expected is known as an acidification defect.
http://purl.obolibrary.org/obo/HP_0031034	Abnormal circulating insulin-like growth factor-binding protein acid labile subunit concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of insulin-like growth factor-binding protein acid labile subunit in the blood circulation.
http://purl.obolibrary.org/obo/HP_0031035	Chronic infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.
http://purl.obolibrary.org/obo/HP_0031036	Decreased circulating GH-binding protein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of GH-binding protein (= growth hormone-binding protein) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031037	Reduced insulin-like factor 3 level	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Blood concentration of insulin-like factor 3 (ILF3) is below normal limits.
http://purl.obolibrary.org/obo/HP_0031038	Spermatogenesis maturation arrest	http://purl.obolibrary.org/obo/HP_0008669	Abnormal spermatogenesis		Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa.
http://purl.obolibrary.org/obo/HP_0031039	Spermatocyte maturation arrest	http://purl.obolibrary.org/obo/HP_0031038	Spermatogenesis maturation arrest		A type of spermatogenesis maturation arrest in which the block of developmental occurs in the spermatocyte stage. Testicular histology shows seminiferous tubules with Sertoli cells, spermatogonial cells and spermatocytes but no further differentiated cells like round spermatids.
http://purl.obolibrary.org/obo/HP_0031040	Round spermatid arrest	http://purl.obolibrary.org/obo/HP_0031038	Spermatogenesis maturation arrest		A failure of spermatogenesis to progress beyond the round spermatid stage. The round spermatid is the first haploid cells produced during spermatogenesis and normally further develop into mature spermatozoa. This abnormality can be visualized with testicular biopsy and is characterized seminiferous tubules with increased numbers of round spermatids with few or no mature spermatozoa.
http://purl.obolibrary.org/obo/HP_0031041	Obstruction of the superior vena cava	http://purl.obolibrary.org/obo/HP_0025575	Abnormal superior vena cava morphology		Blockage of blood flow through the superior vena cava (SVC). Because the venous drainage from the upper extremities, upper thorax and head is obstructed, SVC obstruction presents with symptoms related to engorgement of these areas. Both the degree of SVC compromise and the extent of collateral veins determine the varied clinical presentation, which can be as mild as slight facial and upper extremity edema or as dire as intracranial swelling, seizures, hemodynamic instability and tracheal obstruction.
http://purl.obolibrary.org/obo/HP_0031042	Strawberry tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		Inflamed tongue with hyperplastic (enlarged) fungiform papillae that is said to resemble a strawberry or raspberry.
http://purl.obolibrary.org/obo/HP_0031043	Type A4 brachydactyly	http://purl.obolibrary.org/obo/HP_0009370	Type A brachydactyly		A type of brachydactyly characterized by brachymesophalangy affecting mainly the 2nd and 5th digits.
http://purl.obolibrary.org/obo/HP_0031044	Type A5 brachydactyly	http://purl.obolibrary.org/obo/HP_0009370	Type A brachydactyly		A type of brachydactyly characterized by absent middle phalanges of digits 2 to 5.
http://purl.obolibrary.org/obo/HP_0031045	Acral blistering	http://purl.obolibrary.org/obo/HP_0033800	Blistering by anatomical location		Bullae (defined as fluid-filled blisters more than 5 mm in diameter with thin walls) of the skin with an acral distribution (affecting peripheral regions such as hands and feet).
http://purl.obolibrary.org/obo/HP_0031046	Absent soft palate	http://purl.obolibrary.org/obo/HP_0100736	Abnormal soft palate morphology		A developmental defect characterized by lack of a soft palate.
http://purl.obolibrary.org/obo/HP_0031048	Light-chain paraproteinemia	http://purl.obolibrary.org/obo/HP_0031047	Paraproteinemia		An abnormal immunoglobulin light chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.
http://purl.obolibrary.org/obo/HP_0031049	Heavy-chain paraproteinemia	http://purl.obolibrary.org/obo/HP_0031047	Paraproteinemia		An abnormal immunoglobulin heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.
http://purl.obolibrary.org/obo/HP_0031050	Whole-immunoglobulin paraproteinemia	http://purl.obolibrary.org/obo/HP_0031047	Paraproteinemia		An abnormal immunoglobulin (heavy and light chain) in the circulation and typically produced by a clonal population of B-cell derived plasma cells.
http://purl.obolibrary.org/obo/HP_0031052	Elevated vascular endothelial growth factor level	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Increased blood concentration of vascular endothelial growth factor (VEGF).
http://purl.obolibrary.org/obo/HP_0031053	Coarctation in the transverse aortic arch	http://purl.obolibrary.org/obo/HP_0001680	Coarctation of aorta		Narrowing or constriction of the aorta localized to the region of the transverse aortic arch.
http://purl.obolibrary.org/obo/HP_0031054	Long segment coarctation of the aorta	http://purl.obolibrary.org/obo/HP_0001680	Coarctation of aorta		Coarctation of the aorta is a narrowing or constriction of a long segment of the arch of the aorta.
http://purl.obolibrary.org/obo/HP_0031056	Fusiform cerebral aneurysm	http://purl.obolibrary.org/obo/HP_0004944	Dilatation of the cerebral artery		A localized circumferential (i.e., bulges on all sides) dilatation or ballooning of a cerebral artery.
http://purl.obolibrary.org/obo/HP_0031057	Skin fissure	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A clearly-defined and roughly linear cleavage in the skin that usually extends to the dermis.
http://purl.obolibrary.org/obo/HP_0031058	Impairment of activities of daily living	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		Difficulty in performing one or more activities normally performed every day, such as eating, bathing, dressing, grooming, work, homemaking, and leisure.
http://purl.obolibrary.org/obo/HP_0031059	Impaired ability to bathe oneself	http://purl.obolibrary.org/obo/HP_0031058	Impairment of activities of daily living		This term applies to an individual who requires help to bathe more than one part of the body, get in or out of the tub or shower, or who requires total bathing.
http://purl.obolibrary.org/obo/HP_0031060	Impaired ability to dress oneself	http://purl.obolibrary.org/obo/HP_0031058	Impairment of activities of daily living		This applies to an individual who needs help with dressing or needs to be completely dressed.
http://purl.obolibrary.org/obo/HP_0031061	Impaired toileting ability	http://purl.obolibrary.org/obo/HP_0031058	Impairment of activities of daily living		This term applies to an individual who requires help transferring to the toilet, cleaning self or who uses bedpan or commode.
http://purl.obolibrary.org/obo/HP_0031062	Impaired transferring ability	http://purl.obolibrary.org/obo/HP_0031058	Impairment of activities of daily living		Applies to an individual who needs help in moving from bed to chair or requires a complete transfer.
http://purl.obolibrary.org/obo/HP_0031063	Impaired feeding ability	http://purl.obolibrary.org/obo/HP_0031058	Impairment of activities of daily living		Applies to an individual who needs partial or total help with feeding or requires parenteral feeding.
http://purl.obolibrary.org/obo/HP_0031067	Empty ovarian follicle	http://purl.obolibrary.org/obo/HP_0031066	Abnormal ovarian physiology		A failure to collect oocytes after an apparently normal controlled ovarian hyperstimulation cycle for in vitro fertilization.
http://purl.obolibrary.org/obo/HP_0031069	Abnormal femoral torsion	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		Femoral torsion, also known as femoral rotation or femoral version, refers to the twist between the proximal and distal parts of the femur on the transverse plane. Femoral anteversion averages between 30-40 degrees at birth, and between 8-14 degrees in adults. This term applies if the amount of femoral torsion deviates from this range.
http://purl.obolibrary.org/obo/HP_0031071	Abnormal endocrine morphology	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		Any anomaly of the structure of an organ ofthe endocrine system.
http://purl.obolibrary.org/obo/HP_0031072	Abnormal endocrine physiology	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the endocrine system		Any anomaly of the function of the endocrine system.
http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test	http://purl.obolibrary.org/obo/HP_0031072	Abnormal endocrine physiology		An anomalous response to a test that is designed to probe the function of the endocrine system.
http://purl.obolibrary.org/obo/HP_0031074	Abnormal response to ACTH stimulation test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		An anomalous response to stimulation by administration of the adrenocorticotropic hormone (ACTH). ACTH stimulation normally stimulates the adrenal glands to release cortisol and adrenaline.
http://purl.obolibrary.org/obo/HP_0031075	Abnormal response to insulin tolerance test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		An anomalous response to the insulin tolerance test (ITT), in which insulin is administered intravenously and blood glucose and potentially other compounds are measured at intervals. Insulin administration is intended to induce extreme hypoglycemia (bloodgluoce below 40 mg/dl), which in turn induces release of adrenocorticotropic hormone (ACTH) and growth hormone (GH). ACTH induces the adrenal gland to release cortisol, which together with GH opposes the action of insulin on the blood glucose level.
http://purl.obolibrary.org/obo/HP_0031076	Impaired cortisol response to insulin stimulation test	http://purl.obolibrary.org/obo/HP_0031075	Abnormal response to insulin tolerance test		Failure of cortisol levels to respond adequately (by increasing) to the insulin tolerance test (ITT).
http://purl.obolibrary.org/obo/HP_0031077	Abnormal response to corticotropin releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		An anomalous response to the corticotropin releasing hormone (CRH) stimulation test. Normally,CRH is released by the hypothalamus to induce adrenocorticotropic hormone (ACTH) release by the anterior pituitary. In the stimulation test, CRH is administered intravenously and ACTH and cortisol are measured at intervals.
http://purl.obolibrary.org/obo/HP_0031078	Impaired cortisol response to corticotropin releasing hormone stimulation test	http://purl.obolibrary.org/obo/HP_0031077	Abnormal response to corticotropin releasing hormone stimulation test		Failure of cortisol levels to respond adequately (by increasing) to the corticotropin releasing hormone stimulation test.
http://purl.obolibrary.org/obo/HP_0031079	Impaired growth-hormone response to insulin stimulation test	http://purl.obolibrary.org/obo/HP_0031075	Abnormal response to insulin tolerance test		Failure of growth hormone levels to respond adequately (by increasing) to the insulin tolerance test (ITT).
http://purl.obolibrary.org/obo/HP_0031080	Abnormal response to glucagon stimulation test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		An anomalous response to the glucagon stimulation test, which like the insulin tolerance test (ITT) stimulates the release of both adrenocorticotropic hormone (ACTH) and growth hormone (GH).
http://purl.obolibrary.org/obo/HP_0031081	Impaired cortisol response to glucagon stimulation test	http://purl.obolibrary.org/obo/HP_0031080	Abnormal response to glucagon stimulation test		Failure of cortisol levels to respond adequately (by increasing) to the glucagon stimulation test.
http://purl.obolibrary.org/obo/HP_0031082	Impaired growth-hormone response to glucagon stimulation test	http://purl.obolibrary.org/obo/HP_0031080	Abnormal response to glucagon stimulation test		Failure of growth hormone levels to respond adequately (by increasing) to the glucagon stimulation test.
http://purl.obolibrary.org/obo/HP_0031083	Abnormal response to human chorionic gonadotrophin stimulation test	http://purl.obolibrary.org/obo/HP_0031073	Abnormal response to endocrine stimulation test		An anomalous response to intravenous stimulation by human chorionic gonadotrophin. Stimulation with hCG stimulates testicular Leydig cells to secrete androgens via the Leydig hormone receptors.
http://purl.obolibrary.org/obo/HP_0031084	Excessive insulin response to glucagon test	http://purl.obolibrary.org/obo/HP_0031080	Abnormal response to glucagon stimulation test		An abnormally high increase in insulin levels following a glucagon stimulation test.
http://purl.obolibrary.org/obo/HP_0031085	Decreased circulating prealbumin concentration	http://purl.obolibrary.org/obo/HP_0033450	Abnormal circulating prealbumin concentration		The concentration of prealbumin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031086	Ectopic ovary	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		Undescended or ectopic ovaries are characterized by the attachment of the upper pole of the ovary to an area above the level of the common iliac vessels.
http://purl.obolibrary.org/obo/HP_0031087	Absent pubertal growth spurt	http://purl.obolibrary.org/obo/HP_0001510	Growth delay		The abrupt and transient increase in the annual growth rate normally observed in adolescent individuals does not occur.
http://purl.obolibrary.org/obo/HP_0031088	Vaginal dryness	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		Persistent vaginal dryness.
http://purl.obolibrary.org/obo/HP_0031089	Palatal edema	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		Swelling related to fluid accumulation within the palate.
http://purl.obolibrary.org/obo/HP_0031090	Finger dactylitis	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Fingers appear swollen and plump owing to inflammation of the complete finger.
http://purl.obolibrary.org/obo/HP_0031091	Toe dactylitis	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Toes appear swollen and plump owing to inflammation of the complete toe.
http://purl.obolibrary.org/obo/HP_0031092	Spindle-shaped finger	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		Swelling of the hand at the knuckles, that gives the fingers a spindle shape (i.e., a round stick with tapered end and a broader base).
http://purl.obolibrary.org/obo/HP_0031096	Delayed vertebral ossification	http://purl.obolibrary.org/obo/HP_0100569	Abnormally ossified vertebrae		A decrease in the amount of mineralized bone in one or more vertebrae compared with that expected for a given developmental age.
http://purl.obolibrary.org/obo/HP_0031098	Decreased thyroid-stimulating hormone level	http://purl.obolibrary.org/obo/HP_0031097	Abnormal circulating thyroid-stimulating hormone concentration		Reduced amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0031099	Abnormal circulating inhibin level	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal concentration of inhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone.
http://purl.obolibrary.org/obo/HP_0031100	Decreased circulating inhibin B concentration	http://purl.obolibrary.org/obo/HP_0430147	Abnormal circulating inhibin B concentration		The concentration of inhibin B in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031101	Abnormal circulating antimullerian hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases.
http://purl.obolibrary.org/obo/HP_0031102	Increased circulating antimullerian hormone concentration	http://purl.obolibrary.org/obo/HP_0031101	Abnormal circulating antimullerian hormone concentration		An elevation above the normal range of the antimullerian hormone in the circulation.
http://purl.obolibrary.org/obo/HP_0031103	Decreased circulating antimullerian hormone circulation	http://purl.obolibrary.org/obo/HP_0031101	Abnormal circulating antimullerian hormone concentration		A reduction below the normal range of the antimullerian hormone in the circulation.
http://purl.obolibrary.org/obo/HP_0031104	Insulin receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against the insulin receptor.
http://purl.obolibrary.org/obo/HP_0031106	T-shaped uterus	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		An abnormality of the uterus characterized by a normal uterine outline but with an abnormal T-shaped uterine cavity with narrowing cavity due to thickened lateral walls with a correlation 2/3 uterine corpus and 1/3 cervix. The abnormlaity is said to resemble the letter T in hysterosalpingographic imaging.
http://purl.obolibrary.org/obo/HP_0031107	Decreased fibular diameter	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		Reduced width of the cross sectional diameter of the fibula.
http://purl.obolibrary.org/obo/HP_0031108	Triceps weakness	http://purl.obolibrary.org/obo/HP_0008997	Proximal upper limb muscle weakness		A lack of strength in the triceps muscle, which normally is responsible for extending (straightening) the elbow and mediating certain shoulder movements.
http://purl.obolibrary.org/obo/HP_0031117	Purely bicuspid aortic valve	http://purl.obolibrary.org/obo/HP_0001647	Bicuspid aortic valve		A type of bicuspid aortic valve (BAV) characterized by two equal-sized cusps, with no raphe and only two commissures. There is a lateral arrangement of the free edge of the cusps. Note that this differs from some other forms of BAV in which there are three commissures and two of the three cusps are joined by a raphe forming two functional leaflets. This type of BAV often is associated with aortic stenosis.
http://purl.obolibrary.org/obo/HP_0031118	Single raphe bicuspid aortic valve	http://purl.obolibrary.org/obo/HP_0001647	Bicuspid aortic valve		A type of bicuspid aortic valvue (BAV) characterized by the presence of a single raphe that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps, resulting in two leaflets of unequal size.
http://purl.obolibrary.org/obo/HP_0031119	Bicuspid aortic valve with right-left cusp fusion	http://purl.obolibrary.org/obo/HP_0031118	Single raphe bicuspid aortic valve		A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and left cusps (RL fusion pattern). This results in two leaflefts with an anterior-posterior leaflet orientation (also called the typical pattern). There is thus one completely developed noncoronary cusp, two completely developed commissures, and one raphe between the underdeveloped left and right coronary cusps extending to the corresponding malformed commissure.
http://purl.obolibrary.org/obo/HP_0031120	Bicuspid aortic valve with right-noncoronary cusp fusion	http://purl.obolibrary.org/obo/HP_0031118	Single raphe bicuspid aortic valve		A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and noncoronary cusps (RN fusion pattern). This results in two leaflets with right-left leaflet orientation (also called the atypical pattern). There is thus one completely developed left cusp, two completely developed commissures, and one raphe between the underdeveloped right and noncoronary coronary cusps extending to the corresponding malformed commissure.
http://purl.obolibrary.org/obo/HP_0031121	Bicuspid aortic valve with left-noncoronary cusp fusion	http://purl.obolibrary.org/obo/HP_0031118	Single raphe bicuspid aortic valve		A type of bicuspid aortic valve (BAV) characterized by a single raphe between the left and noncoronary cusps (LN fusion pattern). There is thus one completely developed right cusp, two completely developed commissures, and one raphe between the underdeveloped left and noncoronary coronary cusps extending to the corresponding malformed commissure.
http://purl.obolibrary.org/obo/HP_0031122	Two-raphe bicuspid aortic valve	http://purl.obolibrary.org/obo/HP_0001647	Bicuspid aortic valve		A type of bicuspid aortic valvue (BAV) characterized by the presence of two raphes that each extend from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV has developmental anlagen of three cusps, commissures, and sinuses, but two commissures are more or less malformed and obliterated, giving rise to a raphe, a fibrous ridge, which extends from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV is typically associated with a high degree of aortic stenosis.
http://purl.obolibrary.org/obo/HP_0031123	Recurrent gastroenteritis	http://purl.obolibrary.org/obo/HP_0004798	Recurrent infection of the gastrointestinal tract		Increased susceptibility to gastroenteritis, an infectious inflammationof the stomach and small intestines manifested by signs and symptoms such as diarheas and abdominal pain, as manifested by recurrent episodes of gastroenteritis.
http://purl.obolibrary.org/obo/HP_0031124	Decreased platelet thromboxane A2 receptor	http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression		Decreased cell membrane concentration of thromboxane A2 receptor that is stimulated by thromboxane A2 (TBXA2).
http://purl.obolibrary.org/obo/HP_0031125	Decreased platelet alpha-2A-adrenergic receptor	http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression		Decreased cell membrane concentration of alpha-2A adrenergic receptor that is stimulated by epinephrine.
http://purl.obolibrary.org/obo/HP_0031126	Impaired clot retraction	http://purl.obolibrary.org/obo/HP_0011869	Abnormal platelet function		Platelets contain contractile proteins (actin and myosin) that induce clot retraction. As the platelets contract, they pull on the surrounding fibrin strands, squeezing serum form the mass, compacting the clot and drawing the ruptured edges of the blood vessel more closely together. Clot retraction is directly proportional to the platelet count and inversely proportional to the fibrinogen concentration.
http://purl.obolibrary.org/obo/HP_0031127	Impaired convulxin-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to convulxin as manifested by reduced or lacking aggregation of platelets upon addition of convulxin.
http://purl.obolibrary.org/obo/HP_0031128	Impaired collagen-related peptide-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to collagen-related peptide (CRP) as manifested by reduced or lacking aggregation of platelets upon addition of CRP.
http://purl.obolibrary.org/obo/HP_0031129	Impaired phorbol myristate acetate-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to phorbol myristate acetate (PMA) as manifested by reduced or lacking aggregation of platelets upon addition of PMA.
http://purl.obolibrary.org/obo/HP_0031130	Impaired calcium ionophore-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540	Impaired platelet aggregation		Abnormal response to calcium Ionophore (such as A23187) as manifested by reduced or lacking aggregation of platelets upon addition of the ionophore.
http://purl.obolibrary.org/obo/HP_0031131	Abnormal platelet phosphatidylserine exposure	http://purl.obolibrary.org/obo/HP_0011869	Abnormal platelet function		An abnormality of phosphatidylserine (PS) on activated platelets. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the plasma-oriented surface of discrete membrane vesicles that derive from activated platelets. Thrombin, the central molecule of coagulation, is produced from prothrombin by a complex (prothrombinase) between factor Xa and its protein cofactor (factor V(a)) that forms on platelet-derived membranes. This complex enhances the rate of activation of prothrombin to thrombin by roughly 150,000 fold relative to factor X(a) in solution. The negatively charged surface of PS-containing platelet-derived membranes is at least partly responsible for this rate enhancement.
http://purl.obolibrary.org/obo/HP_0031132	Impaired annexin V binding to platelet phosphatidylserine	http://purl.obolibrary.org/obo/HP_0031131	Abnormal platelet phosphatidylserine exposure		Reduced binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031133	Increased annexin V binding to platelet phosphatidylserine	http://purl.obolibrary.org/obo/HP_0031132	Impaired annexin V binding to platelet phosphatidylserine		Elevated binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry.
http://purl.obolibrary.org/obo/HP_0031134	Cor triatriatum sinister	http://purl.obolibrary.org/obo/HP_0010774	Cor triatriatum		A developmental anomaly of the heart characterized by the presence of three atria because the left atrium is divided by an abnormal septum.
http://purl.obolibrary.org/obo/HP_0031135	Triggered by physical trauma	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure to a trauma (injury to tissue).
http://purl.obolibrary.org/obo/HP_0031136	Decreased acrosin in sperm head	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		A reduced amount of the enzyme acrosin in the sperm head acrosome. The acrosome is an organelle in the anterior half of the head of spermatozoa, and acrosin is a protease that contributes to the digestation of the zona pellucida in the fertilization process.
http://purl.obolibrary.org/obo/HP_0031138	Abnormal circulating B-type natriuretic peptide concentration	http://purl.obolibrary.org/obo/HP_6000692	Abnormal circulating proANP concentration		A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP).
http://purl.obolibrary.org/obo/HP_0031139	Frog-leg posture	http://purl.obolibrary.org/obo/HP_0001252	Hypotonia		A type of rest posture in an infant that indicated a generalized reduction in muscle tone. The hips are flexed and the legs are abducted to an extent that causes the lateral thigh to rest upon the supporting surface. This posture is said to resemble the legs of a frog.
http://purl.obolibrary.org/obo/HP_0031140	Abnormal liver sonography	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		An abnormal appearance of the liver or any of its components on sonography (ultrasound).
http://purl.obolibrary.org/obo/HP_0031141	Increased hepatic echogenicity	http://purl.obolibrary.org/obo/HP_0031142	Abnormal hepatic echogenicity		Increased echogenicity of liver tissue on sonography, manifested as an increased amount of white on the screen of the sonography device.
http://purl.obolibrary.org/obo/HP_0031142	Abnormal hepatic echogenicity	http://purl.obolibrary.org/obo/HP_0031140	Abnormal liver sonography		Any deviation from the normal degree of echogenicity of the liver on sonography. Echogenicity refers to the ability of a tissue to reflect or transmit ultrasound waves in the context of surrounding tissues. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. Based on echogenicity, a structure can be characterized as hyperechoic (white on the screen), hypoechoic (gray on the screen) and anechoic (black on the screen).
http://purl.obolibrary.org/obo/HP_0031143	Decreased hepatic echogenicity	http://purl.obolibrary.org/obo/HP_0031142	Abnormal hepatic echogenicity		Reduced echogenicity of liver tissue on sonography, manifested as an increased amount of black on the screen of the sonography device.
http://purl.obolibrary.org/obo/HP_0031144	Coarsened hepatic echotexture	http://purl.obolibrary.org/obo/HP_0031140	Abnormal liver sonography		The appearance of the liver in sonographic images is normally uniform. This term applies when there is an irregular or non-uniform appearance of the liver parenchyma in liver sonography.
http://purl.obolibrary.org/obo/HP_0031145	Starry sky appearance on hepatic sonography	http://purl.obolibrary.org/obo/HP_0031140	Abnormal liver sonography		An abnormal echotexture visible in liver ultrasound manifesting as a diffuse hyperechoic liver echotexture with multiple, small hypoechoic lesions. The appearance is said to resemble a starry sky (multiple white spots on a dark background).
http://purl.obolibrary.org/obo/HP_0031146	Impaired oral bolus formation	http://purl.obolibrary.org/obo/HP_0002015	Dysphagia		An abnormality of swallowing characterized by reduced tongue coordination to form bolus after chewing. Food material spreads over the oral cavity instead of being concentrated into a bolus that is easily swallowed.
http://purl.obolibrary.org/obo/HP_0031150	Vitreomacular adhesion	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Perifoveal vitreous separation with remaining vitreomacular attachment and unperturbed foveal morphologic features. It is an OCT finding that is almost always the result of normal vitreous aging, which may lead to pathologic conditions.
http://purl.obolibrary.org/obo/HP_0031151	Vitreomacular traction	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Vitreomacular traction is characterized by anomalous posterior vitreous detachment accompanied by anatomic distortion of the fovea, which may include pseudocysts, macular schisis, cystoid macular edema, and subretinal fluid. Vitreomacular traction can be subclassified by the diameter of vitreous attachment to the macular surface as measured by OCT, with attachment of 1500 micrometers or less defined as focal and attachment of more than 1500 micrometers as broad.
http://purl.obolibrary.org/obo/HP_0031152	Full-thickness macular hole	http://purl.obolibrary.org/obo/HP_0011508	Macular hole		Full-thickness macular hole (FTMH) is defined as a foveal lesion with interruption of all retinal layers from the internal limiting membrane to the retinal pigment epithelium. Full-thickness macular hole is primary if caused by vitreous traction or secondary if directly the result of pathologic characteristics other than vitreomacular traction. Full-thickness macular hole is subclassified by size of the hole as determined by OCT and the presence or absence of vitreomacular traction.
http://purl.obolibrary.org/obo/HP_0031153	Membranous vitreous appearance	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Vitreous humor of the eye displaying consisting of a vestigial gel in the retrolental space bounded by a convoluted membrane.
http://purl.obolibrary.org/obo/HP_0031154	Beaded vitreous appearance	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		Vitreous humor of the eye displaying beaded bundles of irregular diameters.
http://purl.obolibrary.org/obo/HP_0031155	Increased Arden ratio of electrooculogram	http://purl.obolibrary.org/obo/HP_0030454	Abnormal electrooculogram		An abnormal increase in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record.
http://purl.obolibrary.org/obo/HP_0031156	Decreased platelet glycoprotein Ib	http://purl.obolibrary.org/obo/HP_0011878	Abnormal platelet membrane protein expression		Decreased platelet cell membrane concentration of glycoprotein Ib.
http://purl.obolibrary.org/obo/HP_0031157	Carotid cavernous fistula	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		An abnormal connection between a carotid artery and the cavernous sinus.
http://purl.obolibrary.org/obo/HP_0031158	Widened atrophic scar	http://purl.obolibrary.org/obo/HP_0001075	Atrophic scars		An atrophic scar (fibrous connective tissue resulting from incomplete healing of a wound) that has stretched (gotten wider), a manifestation of tissue fragility.
http://purl.obolibrary.org/obo/HP_0031159	Thinning of Descemet membrane	http://purl.obolibrary.org/obo/HP_0011490	Abnormal Descemet membrane morphology		A reduction in the thickness of Descemet's membrane.
http://purl.obolibrary.org/obo/HP_0031160	Myelokathexis	http://purl.obolibrary.org/obo/HP_0012135	Abnormal granulocytopoietic cell morphology		Impaired egress of mature neutrophils from bone marrow causing neutropenia.
http://purl.obolibrary.org/obo/HP_0031161	Reduced brain glutamate level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An decrease in the level of glutamate (Glu) in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0031162	Impaired oropharyngeal swallow response	http://purl.obolibrary.org/obo/HP_0002015	Dysphagia		Delay or absence of the swallow response, reflexes triggered by the contact the food bolus makes with the anterior faucial pillars.
http://purl.obolibrary.org/obo/HP_0031163	Low femoral bone density	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		Reduced bone mineral density of the femur.
http://purl.obolibrary.org/obo/HP_0031164	Growth arrest lines	http://purl.obolibrary.org/obo/HP_0031367	Metaphyseal striations		Growth arrest lines are alternating transverse rings of sclerosis at the metaphysis of a long bone.
http://purl.obolibrary.org/obo/HP_0031165	Multifocal seizures	http://purl.obolibrary.org/obo/HP_0007359	Focal-onset seizure		Seizures that start from several different areas of the brain (i.e., with multiple ictal onset locations).
http://purl.obolibrary.org/obo/HP_0031166	Eyelid myokymia	http://purl.obolibrary.org/obo/HP_0002411	Myokymia		Involuntary, fine, continuous, undulating contractions of the eyelid.
http://purl.obolibrary.org/obo/HP_0031167	Triggered by ingestion of potassium-rich food	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by eating or drinking foods rich in potassium.
http://purl.obolibrary.org/obo/HP_0031169	Postterm pregnancy	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		A pregnancy that extends to 42 weeks of gestation or beyond.
http://purl.obolibrary.org/obo/HP_0031170	Female fetal virilization	http://purl.obolibrary.org/obo/HP_0034242	Abnormal fetal genitourinary system morphology		Fetal masculinization of female external genitalia.
http://purl.obolibrary.org/obo/HP_0031171	Femoral spur	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		A bony projection (spur, osteophyte) originating from the femur, often in the medial femoral neck.
http://purl.obolibrary.org/obo/HP_0031172	Sectoral retinitis pigmentosa	http://purl.obolibrary.org/obo/HP_0000510	Rod-cone dystrophy		A variant of retinitis pigmentosa in which there is a regional distribution of the retinal degeneration.
http://purl.obolibrary.org/obo/HP_0031173	Tibial spur	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		A bony projection (spur, osteophyte) originating from the tibia.
http://purl.obolibrary.org/obo/HP_0031174	Double-layered patella	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		An anomaly of the patella characterized by two layers visible on lateral knee X-ray such that one layer is in front of the other in the sagittal orientation (See Figure 2A and 3B of PMID:12966518). This finding persists into adulthood.
http://purl.obolibrary.org/obo/HP_0031175	Absent cervical vertebra	http://purl.obolibrary.org/obo/HP_0008465	Absent vertebra		A developmental defect characterized by agenesis of one or more vertebral bodies of the cervical spine.
http://purl.obolibrary.org/obo/HP_0031176	Absent thoracic vertebra	http://purl.obolibrary.org/obo/HP_0008465	Absent vertebra		A developmental defect characterized by agenesis of one or more vertebral bodies of the thoracic spine.
http://purl.obolibrary.org/obo/HP_0031177	Finger flexor weakness	http://purl.obolibrary.org/obo/HP_0030237	Hand muscle weakness		Reduced ability to flex (bend) the fingers. This can manifest as incomplete closure of the hand due to weakness in finger flexion.
http://purl.obolibrary.org/obo/HP_0031178	Fixed head retroflexion	http://purl.obolibrary.org/obo/HP_0000234	Abnormality of the head		Head is bent in the posterior direction in a permanent fashion.
http://purl.obolibrary.org/obo/HP_0031179	Nuchal rigidity	http://purl.obolibrary.org/obo/HP_0005986	Limitation of neck motion		Resistance of the extensor muscles of the neck to being bent forwards (i.e., impaired neck flexion) as a result of muscle spasm of the extensor muscles of the neck. Nuchal rigidity is not a fixed rigidity. Nuchal rigidity has been used as a bedside test for meningism, although its sensitivity for this purpose has been debated.
http://purl.obolibrary.org/obo/HP_0031180	Erythema migrans	http://purl.obolibrary.org/obo/HP_0010783	Erythema		An expanding erythematous (red) skin lesion, usually round or oval, by definition at least 5 cm in size (in largest diameter).
http://purl.obolibrary.org/obo/HP_0031181	Necrolytic migratory erythema	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution.
http://purl.obolibrary.org/obo/HP_0031185	Elevated circulating NT-proBNP concentration	http://purl.obolibrary.org/obo/HP_0031138	Abnormal circulating B-type natriuretic peptide concentration		The concentration of NT-proBNP (= N-terminal pro-B-type natriuretic peptide, = N-terminal prohormone of brain natriuretic peptide) in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031186	Abnormal circulating deoxycorticosterone level	http://purl.obolibrary.org/obo/HP_0012112	Abnormal circulating corticosterone level		An abnormality of the concentration of deoxycorticosterone in the blood. Deoxycorticosterone comprises 11-deoxycorticosterone and 21-deoxycorticosterone.
http://purl.obolibrary.org/obo/HP_0031187	Abnormal circulating pregnenolone concentration	http://purl.obolibrary.org/obo/HP_0033799	Abnormal circulating sex hormone concentration		An abnormality of the concentration of pregnenolone in the blood.
http://purl.obolibrary.org/obo/HP_0410020	Fish odor	http://purl.obolibrary.org/obo/HP_0500001	Body odor		Body odor characterized by an offensive body odor and the smell of rotting fish due to the excessive excretion of trimethylamine (TMA) in the urine, sweat, and breath of affected individuals.
http://purl.obolibrary.org/obo/HP_0410021	Musty odor	http://purl.obolibrary.org/obo/HP_0500001	Body odor		Pungent body odor.
http://purl.obolibrary.org/obo/HP_0410022	Vaginal fish odor	http://purl.obolibrary.org/obo/HP_0410020	Fish odor		A fish odor in the vaginal area, that is characteristic of bacterial vaginosis (BV), and is due to trimethylamine (TMA).
http://purl.obolibrary.org/obo/HP_0410026	Abnormal periodontium morphology	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		Any abnormality of the periodontium.
http://purl.obolibrary.org/obo/HP_0410027	Alveolar bone loss around teeth	http://purl.obolibrary.org/obo/HP_0410026	Abnormal periodontium morphology		A decrease in the amount of alveolar bone around the root of a tooth.
http://purl.obolibrary.org/obo/HP_0410028	Recurrent oral herpes	http://purl.obolibrary.org/obo/HP_0005353	Recurrent herpes		Recurrent episodes of oral herpes, typically characterized by blisters or ulcers on the gums, lips and/or tongue caused by herpes virus.
http://purl.obolibrary.org/obo/HP_0410033	Unilateral alveolar cleft of maxilla	http://purl.obolibrary.org/obo/HP_0010289	Cleft maxillary alveolar ridge		One sided alveolar cleft of the maxilla.
http://purl.obolibrary.org/obo/HP_0410034	Bilateral alveolar cleft of maxilla	http://purl.obolibrary.org/obo/HP_0010289	Cleft maxillary alveolar ridge		Nonmidline alveolar cleft of the maxilla.
http://purl.obolibrary.org/obo/HP_0500001	Body odor	http://purl.obolibrary.org/obo/HP_0025142	Constitutional symptom		A perceived unpleasant smell given off by the body.
http://purl.obolibrary.org/obo/HP_0500005	Anal pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		Pain in and around the anus or rectum (perianal region).
http://purl.obolibrary.org/obo/HP_0500006	Urethritis	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		Inflammation of the urethra.
http://purl.obolibrary.org/obo/HP_0500007	Iris flocculi	http://purl.obolibrary.org/obo/HP_0000525	Abnormality iris morphology		Multiple cysts along the pupillary margin that appear as spherical or tear-drop-shaped pigmented lesions or wrinkled masses emerging from the pupillary border of the iris.
http://purl.obolibrary.org/obo/HP_0500008	Cornea verticillata	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea.
http://purl.obolibrary.org/obo/HP_0500009	Dysplastic gangliocytoma of the cerebellum	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		It is a rare, slowly growing tumor of the cerebellum, a gangliocytoma sometimes considered to be a hamartoma, characterized by diffuse hypertrophy of the granular layer of the cerebellum.
http://purl.obolibrary.org/obo/HP_0500011	Moon facies	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		A rounded, puffy face with fat deposits in the temporal fossa and cheeks, a double chin.
http://purl.obolibrary.org/obo/HP_0500013	Lack of gonadotropin-releasing hormone pulsatility	http://purl.obolibrary.org/obo/HP_0500012	Abnormal gonadotropin-releasing hormone concentration		Secretion of gonadotropin-releasing hormone that does not occur in a pulsatile fashion.
http://purl.obolibrary.org/obo/HP_0500016	Abnormal cardiac MRI	http://purl.obolibrary.org/obo/HP_0500015	Abnormal cardiac test		Abnormal results of a MRI for the heart.
http://purl.obolibrary.org/obo/HP_0500017	Abnormal cardiac catheterization	http://purl.obolibrary.org/obo/HP_0500015	Abnormal cardiac test		Abnormal results from the diagnostic tests resulting from cardiac catheterization.
http://purl.obolibrary.org/obo/HP_0500018	Abnormal cardiac exercise stress test	http://purl.obolibrary.org/obo/HP_0500015	Abnormal cardiac test		Abnormal results of exercise on heart function.
http://purl.obolibrary.org/obo/HP_0500019	Abnormal resting energy expenditure from metabolic cart test	http://purl.obolibrary.org/obo/HP_0500015	Abnormal cardiac test		Resting energy expenditure (REE) can be measured with indirect calorimetry using a metabolic cart, which is used to measure the oxygen consumption (VO2) and carbon dioxide production (VCO2).
http://purl.obolibrary.org/obo/HP_0500020	Abnormal cardiac biomarker test	http://purl.obolibrary.org/obo/HP_0500015	Abnormal cardiac test		Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes.
http://purl.obolibrary.org/obo/HP_0500021	Reduced brain gamma-aminobutyric acid level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		An decreased level of gamma-aminobutyric acid in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0500022	Abnormal circulating dehydroepiandrosterone concentration	http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level		A deviation from the normal concentration of dehydroepiandrosterone in the circulation.
http://purl.obolibrary.org/obo/HP_0500023	Shoulder muscle aplasia	http://purl.obolibrary.org/obo/HP_0001464	Aplasia/Hypoplasia involving the shoulder musculature		Absence of shoulder muscles.
http://purl.obolibrary.org/obo/HP_0500024	Aplasia of the musculature of the pelvis	http://purl.obolibrary.org/obo/HP_0001471	Aplasia/Hypoplasia of the musculature of the pelvis		Absence of the musculature of the pelvis.
http://purl.obolibrary.org/obo/HP_0500026	Hypoplasia of the musculature of the pelvis	http://purl.obolibrary.org/obo/HP_0001471	Aplasia/Hypoplasia of the musculature of the pelvis		Underdevelopment of the musculature of the pelvis.
http://purl.obolibrary.org/obo/HP_0500027	Aplastic colon	http://purl.obolibrary.org/obo/HP_0100811	Aplasia/Hypoplasia of the colon		Congenital absence of the colon
http://purl.obolibrary.org/obo/HP_0500028	Cotton wool plaques	http://purl.obolibrary.org/obo/HP_0100256	Senile plaques		Deposition of large, diffuse cotton wool amyloid plaques (CWPs) lacking a dense core and associated neuritic changes.
http://purl.obolibrary.org/obo/HP_0500031	Sclerosis of the carpal bones	http://purl.obolibrary.org/obo/HP_0004054	Sclerosis of hand bone		An elevation in bone density in one or more carpal bones of the hand.
http://purl.obolibrary.org/obo/HP_0500032	Abnormal neuron branching	http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology		Abnormality of the structure and branching of the dendrites of a neuron.
http://purl.obolibrary.org/obo/GO_0140053	mitochondrial gene expression	http://purl.obolibrary.org/obo/GO_0010467	gene expression		The process of transcribing and translating the mitochondrial genome (mtDNA) to produce at least a subset of oxidative phosphorylation (OXPHOS) proteins, 2 rRNAs, and mitochondrial tRNAs, which are critical for ATP production. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
http://purl.obolibrary.org/obo/UBERON_0036224	corticobulbar and corticospinal tracts	http://purl.obolibrary.org/obo/UBERON_0001018	axon tract		The corticobulbar and corticospinal tracts combined.
http://purl.obolibrary.org/obo/UBERON_0036225	respiratory system gland	http://purl.obolibrary.org/obo/UBERON_0002530	gland		Any gland that is part os the respiratory system.
http://purl.obolibrary.org/obo/GO_0099160	postsynaptic intermediate filament cytoskeleton	http://purl.obolibrary.org/obo/GO_0099571	postsynaptic cytoskeleton		The intermediate filament cytoskeleton that is part of a postsynapse.
http://purl.obolibrary.org/obo/UBERON_0036245	parenchyma of mammary gland	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		Parenchymal tissue that consists of the alveoli, grape-like clusters where milk is stored, and branching ducts, which are tubular canals carrying gladular secretions.
http://purl.obolibrary.org/obo/UBERON_0036246	incudostapedial joint	http://purl.obolibrary.org/obo/UBERON_0036248	joint of auditory ossicle		The small synovial joint connecting the inclus and the stapes, located between the lenticular process on the long crus of the incus and the head of the stapes.
http://purl.obolibrary.org/obo/UBERON_0036247	incudomallear joint	http://purl.obolibrary.org/obo/UBERON_0036248	joint of auditory ossicle		The saddle-shaped synovial joint connecting the incus and the malleus.
http://purl.obolibrary.org/obo/UBERON_0036248	joint of auditory ossicle	http://purl.obolibrary.org/obo/UBERON_0002217	synovial joint		Any synovial joint that connects auditory ossicles.
http://purl.obolibrary.org/obo/GO_0120111	neuron projection cytoplasm	http://purl.obolibrary.org/obo/GO_0005737	cytoplasm		All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.
http://purl.obolibrary.org/obo/CHEBI_139120	carotenoid beta-end derivative	http://purl.obolibrary.org/obo/CHEBI_23044	carotenoid		Any carotenoid derivative with an β-end group
http://purl.obolibrary.org/obo/HP_0020035	Lower limb dysmetria	http://purl.obolibrary.org/obo/HP_0002406	Limb dysmetria		A lack of coordination of leg movement manifested by undershoot or overshoot of the intended position of the leg.
http://purl.obolibrary.org/obo/HP_0020036	Upper limb dysmetria	http://purl.obolibrary.org/obo/HP_0002406	Limb dysmetria		A lack of coordination of arm movement manifested by undershoot or overshoot of the intended position of the arm.
http://purl.obolibrary.org/obo/HP_0020037	Astasia	http://purl.obolibrary.org/obo/HP_0100022	Abnormality of movement		A postural abnormality characterized by the inability to stand without external support despite having sufficient muscle strength.
http://purl.obolibrary.org/obo/HP_0020038	Vertebrobasilar dolichoectasia	http://purl.obolibrary.org/obo/HP_0030321	Abnormal vertebral artery morphology		Elongation, dilatation, and/or tortuosity of the vertebrobasilar segment. The definition of VBD includes: (i) diameter of basilar or vertebral artery over 4.5 mm; or (ii) deviation of any portion more than 10 mm from the shortest expected course; and (iii) length of basilar artery over 29.5 mm or length of intracranial vertebral artery over 23.5 mm.
http://purl.obolibrary.org/obo/HP_0031570	Tessier number 0 facial cleft	http://purl.obolibrary.org/obo/HP_0100629	Midline facial cleft		A Number 0 Tessier cleft is a true median cleft lip with a broad columella and bifid nasal tip. The alveolar cleft is between the central incisors. The nasal septum may be thickened, duplicated, or absent. The nasal bridge is usually broad with associated orbital hypertelorism. The midline soft tissue anomaly may range from a mild broadening of the philtrum or there may be a true median cleft lip. The columella and nasal tip are typically bifid and broadened with a midline depression. The alae nasi are intact but laterally displaced. The nose appears shortened in the vertical dimension.
http://purl.obolibrary.org/obo/HP_0031571	Paramedian facial cleft	http://purl.obolibrary.org/obo/HP_0002006	Tessier cleft		A type of facial cleft located near to but not directly on the midline of the face.
http://purl.obolibrary.org/obo/HP_0031572	Tessier number 1 facial cleft	http://purl.obolibrary.org/obo/HP_0031571	Paramedian facial cleft		As seen in a typical cleft lip, a cleft of the lip is found in the region of the cupid's bow. The nostril is cleft through the alar dome and extends above onto the nasal dorsum. It passes medial to a normal, but dys- topic, medial canthus. There is an alveolar cleft between the central and lateral incisors that extends above through the pyriform margin lateral to the anterior nasal spine; the nasal septum is not involved. The bony cleft extends through the nasal bone or between the junction of the nasal bone and frontal process of the maxilla. Above the cleft lip, the clefting of the alar dome is associated with deviation to the opposite side of the shortened and broadened columella and nasal tip. Extension of the soft tissue cleft onto the nasal dorsum can be manifest as a series of vertical soft tissue furrows and ridges. Vertical inner canthal dysto- pia and severe telecanthus mark the superior aspect of the Number 1 facial cleft. A cranial soft tissue extension characterized by a tongue-like projection of the frontal hairline delineates the number 13 cleft. Skeletal clefting of the maxilla may extend posteriorly to form a complete cleft of the hard and soft palate. The maxilla is hypoplastic in all three dimensions. There is a keel-shaped alveolus and anterior open bite. Normal septation is preserved between the nasal cavity and the hypoplastic maxillary antrum on the affected side. Distortion of the nasal skeleton produces gross flattening of the nasal dorsum. There is asymmetry of the pterygoid plates, of the greater and lesser wings of the sphenoid, and of the floor of the anterior cranial fossa. The distortion of the cranial base may result in a mild plagiocephaly.
http://purl.obolibrary.org/obo/HP_0031573	Tessier number 2 facial cleft	http://purl.obolibrary.org/obo/HP_0031571	Paramedian facial cleft		As is typically seen in isolated cleft cases, a cleft of the lip is present. There is hypoplasia, but not true notching of the ala nasi with flattening of the lateral part of the nose. The nasal root is broadened, with lateral displacement of the inner canthus. The palpebral fissure and lacrimal drainage system are not disturbed. The alveolar cleft is through the lateral incisor area and extends to the pyriform aperture. There is normal septation between the nasal cavity and maxillary sinus. Notching at the junction between the nasal bone is present, as is a broad, flat frontal process of the maxilla. Transverse ethmoid enlargement produces orbital hypertelorism. Above the cleft of the lip and palate is a true broad cleft of the nostril that is medial to the intact, but laterally displaced, tail of the alar cartilage. A shallow soft tissue groove extends superiorly to the asymmetrically widened nasal root. The lacrimal system, palpebral fissures, and eyebrows remain intact. The alveolar cleft extends posteriorly as a complete unilateral cleft of the hard and soft palate. The nasal septum is intact but deviated to the opposite side. The nasal cavity remains separated from the normally pneumatized, although hypoplastic, maxilla on the cleft side. Above the nasomaxillary notching, the ethmoid sinus is less well developed, and there is no pneumatization of the frontal sinus on this side. Anterior rotation of the greater and lesser wings of the sphenoid occurs on the cleft side in relation to the narrower orbit and smaller ethmoid sinus. There is mild asymmetry of the anterior cranial fossa, which is narrower on the cleft side. The cranium is brachycephalic with marked occipital flattening.
http://purl.obolibrary.org/obo/HP_0031574	Orbital cleft	http://purl.obolibrary.org/obo/HP_0002006	Tessier cleft		A facial cleft characterized by involvement of the orbit.
http://purl.obolibrary.org/obo/HP_0031575	Tessier number 3 facial cleft	http://purl.obolibrary.org/obo/HP_0031574	Orbital cleft		As in the Number 1 and Number 2 clefts, this cleft extends through the lip in the region of the typical cleft lip; however, it does not extend through the base. The cleft continues superiorly to involve the inner canthus and lower eyelid medial to the inferior lacrimal punctum, thereby disrupting the nasolacrimal system. Microphthalmia may be present. The alveolar cleft is between the lateral incisor and the canine. Absent septation between the nasal cavity and maxillary antrum, together with the distortion of the frontal process of the maxilla and lacrimal fossa, produces direct communication between the orbit, maxillary sinus, and nose. There is hypoplasia of the soft tissue margins of the cleft in the vertical dimension. This produces extreme soft tissue deficiency between the alar base and the cleft of the medial aspect of the lower eyelid. The inferior lacrimal punctum is evident at the lateral margin of the lower eyelid cleft. The lacrimal drainage system ends as an opening directly onto the cheek without communication into the nasal cavity. The globe is normal in size, but it is displaced inferiorly and laterally. The nasal septum shows the characteristic distortion seen in typical cleft lip and palate. There is absence of septation between the nasal cavity on the cleft side and the maxilla. The maxilla is hypoplastic in three dimensions, with a marked reduction in pneumatization. Superior extension of the skeletal clefting into the medial portion of the orbital floor and into the inferior orbital rim in the region of the frontal process of the maxilla allows direct communication between the orbit above and the nasomaxillary region below. There is mild narrowing of the ethmoid sinus and of the body of the sphenoid on the cleft side. The pterygoid process appears anatomically normal, but less displaced from the midline compared with that of the noncleft side. Both the orbit and the floor of the anterior cranial fossa are inferiorly displaced.
http://purl.obolibrary.org/obo/HP_0031576	Tessier number 4 facial cleft	http://purl.obolibrary.org/obo/HP_0031574	Orbital cleft		The cleft lip is midway between the philtral ridge and the commissure of the mouth. The cleft is lateral to the normally shaped and placed nasal ala and passes onto the cheek. The cleft extends through the lower eyelid lateral to the punctum. The lacrimal system and inner canthus are normal. Microphthalmia may be present. The alveolar cleft passes between the lateral incisor and canine, as in the Number 3 cleft. The cleft passes around the pyriform aperture and continues through the portion of the maxillary sinus medial to the infraorbital foramen. The cleft terminates at the medial end of the inferior orbital rim. There is severe vertical soft tissue deficiency in a Number 4 cleft, with the medial margins of the cleft lip extending directly into the medially placed cleft of the lower eyelid. Within the medial segment of the right-sided cleft lip, muscle elements are apparently absent. Muscle bunching is noted in the ipsilateral lateral lip segment, as is seen in a typical unilateral cleft lip. The anatomically normal nasal ala is superiorly displaced in association with a severe deficiency in the overall nasal length. Marked dystopia of the right globe results in its inferior displacement into the medially deficient orbital floor and inferior rim. Both globes are otherwise normal. The complete palatal cleft passes through the maxilla medial to the infraorbital foramen and extends to the medial portion of the inferior orbital rim without evidence of an intact maxillary sinus. Bony septation persists medially, thereby separating the nasal cavity from the orbit, maxillary sinus, and mouth, which are contiguous. Marked midfacial hypoplasia is present. The cleft is manifest as asymmetry of the body of the sphenoid; it is smaller on the right, with asymmetric placement of the pterygoid plates relative to the midline. The orbital floor cleft has no communication with the inferior orbital fissure. The cleft does not extend to the skull base, but there is marked facial asymmetry associated with plagiocephaly.
http://purl.obolibrary.org/obo/HP_0031577	Tessier number 5 facial cleft	http://purl.obolibrary.org/obo/HP_0031574	Orbital cleft		The cleft of the lip is just medial to the oral commissure and extends across the cheek as a furrow. It ends as a cleft at the junction of the middle and lateral third of the lower eyelid. Microphthalmia is frequently present. The alveolar cleft is through the premolar region and extends superiorly through the orbit at the inferolateral part of the rim and floor. There is a vertical soft tissue deficiency between the lateral portion of the lip and the lower eyelid cleft. The left side of the nose shows vertical shortening, and the left alar base is displaced superiorly. Facial asymmetry secondary to the skeletal abnormality is reflected by a vertical orbital dystopia. However, bothglobes are normal, and there is no abnormality of the upper eyelids, eyebrow, forehead, or frontal hairline. The skeletal clefts vary, ranging from a narrow skeletal furrow that traverses the anterior maxillary wall as on the rightto a broad cleft of the maxilla lateral to the infraorbital foramen and maxillary sinus. This latter cleft enters the inferolateral orbital rim and floor without posterior communication with the inferior orbital fissure on the left side. Medial collapse of the lateral maxillary segments is present bilaterally, with reduction in the transverse dimensions of the maxillary arch. Manifestations of the skeletal disturbance in the sphenoid include a shortening and thickening of the lateral orbital walls in the region of the greater wing and mild asymmetric placement of the pterygoid plates relative to the midline. The right-sided pterygoid plates are smaller and closer to the midline. There is minimal asymmetry of the cranial base and calvarium.
http://purl.obolibrary.org/obo/HP_0031578	Tessier number 6 facial cleft	http://purl.obolibrary.org/obo/HP_0100731	Transverse facial cleft		A facial cleft extending from the zygomatic arch to the eye. This zygomaticomaxillary cleft is similar to that typically found in Treacher Collins syndrome. The overlying tissue shows a vertical sclerodermic furrow radiating from the labial commissure or the angle of the mandible across the cheek to a coloboma of the lower eyelid between the middle and lateral one-third. Microphthalmia is not observed. The skeletal cleft is between the maxilla and zygoma; it passes through the inferolateral orbital rim to enter the inferior orbital fissure. No alveolar cleft is present. The zygomatic arch is intact. The soft tissue furrow, which is more apparent on the right, radiates from the oral commissure toward the lateral two-thirds of the lower eyelid. The antimongoloid obliquity of the palpebral fissures is associated with laterally placed lower eyelid clefts and some ectropion. A left-sided anophthalmia is accompanied by adjacent soft tissue hypoplasia and is reflected in a short palpebral fissure, enophthalmos, and minor ptosis of the eyebrow. No abnormality is present in the alveolar arch except for some tilting of the occlusal plane secondary to hypoplasia of the left side of the maxilla. There is a vertical bony groove in the region of the zygomaticomaxillary suture that ends in the inferolateral portion of a small bony orbit. More laterally, the remainder of the zygomatic body and arch is normal in both shape and dimension. The lateral orbital floor is downslanting but intact, and it lacks direct communication with the temporal or infratemporal fossae. The hypoplasia of the left side of the maxilla and orbit is associated with a reduction in the transverse and anteroposterior dimensions of the anterior cranial fossa; mild asymmetry of the middle cranial fossa and calvarium is present. No significant asymmetry of size, shape, or position is present in the sphenoid.
http://purl.obolibrary.org/obo/HP_0031579	Tessier number 7 facial cleft	http://purl.obolibrary.org/obo/HP_0100731	Transverse facial cleft		The temporozygomatic Number 7 cleft is found in both Treacher Collins syndrome and hemifacial microsomia. Soft tissue manifestations include macrostomia, malformations of the external and middle ear, temporalis muscle, variable involvement of the seventh cranial nerve (in hemifacial microsomia), and abnormalities of the preauricular hair in Treacher Collins syndrome. The skeletal cleft is through the pterygomaxillary junction, and vertical maxillary hypoplasia is present. In addition, abnormality of the mandibular ramus, coronoid, and condyle and absence of the zygomatic arch are typically present. A soft tissue furrow extends from the macrostomia laterally and superiorly across the cheek toward the preauricular hairline. The lower eyelids are intact. The anatomy of the external ear is normal, and there are no preauricular tags. Bony clefting is through the pterygomaxillary junction with hypoplasia of the alveolar process in the molar region, thereby producing a posterior open bite. The maxilla is hypoplastic, although the maxillary sinuses are symmetrically pneumatized. The hypoplastic zygomatic body arches upward, but then it takes a downward course and is severely malformed and displaced. The zygoma is continuous posteriorly with an apparently normal zygomatic process of the temporal bone. The mandibular condyle and coronoid process are hypoplastic and asymmetric. There is no antegonial notching of the mandible. Marked cranial base asymmetry, with tilting and asymmetric positioning of the temporomandibular articulations, is present. The anatomy of the sphenoid is abnormal, especially on the right where there is no recognizable medial or lateral pterygoid plate.
http://purl.obolibrary.org/obo/HP_0031580	Tessier number 8 facial cleft	http://purl.obolibrary.org/obo/HP_0100731	Transverse facial cleft		The frontozygomatic or Number 8 cleft is found in both Treacher Collins syndrome and the Goldenhar variant of hemifacial microsomia. Skeletal defects are more prominent in Treacher Collins syndrome, whereas the soft tissue clefting is more typical in cases of ''Goldenhar syndrome''. Soft tissue clefting presents as a dermatocele, a true lateral eyelid coloboma with absence of the outer canthus, and anomalies of the globe itself, especially epibulbar cysts in patients with Goldenhar syndrome. The frontozygomatic bony cleft produces absence of the lateral orbital rim; this border now is formed by the hypoplastic greater wing of the sphenoid. The absence of bony support for the outer canthus produces lateral canthal dystopia and the characteristic antimongoloid slant of the palpebral fissures. Secondary to the bony deficiency in the lateral orbital wall and floor, there is soft tissue continuity between the orbit, temporal fossa, and infratemporal region. Preauricular hairline indicators delineate the Number 8 cleft as the first of the northbound clefts. Complete absence of the bony lateral orbital wall and rim constitute the skeletal element of the Number 8 cleft. The lateral border of the orbit is formed by the greater wing of the sphenoid from which small spicules of bone, which represent the rudimentary zygoma, may be found in Treacher Collins syndrome. The symmetry of the facial anomalies is reflected in the apparently normal symmetric anterior and middle cranial fossae.
http://purl.obolibrary.org/obo/HP_0031581	Tessier number 9 facial cleft	http://purl.obolibrary.org/obo/HP_0031574	Orbital cleft		This is an upper lateral orbital cleft. The soft tissue deformity is in the lateral one-third of the upper eyelid, and the bony cleft is through the superolateral orbital angle. Microphthalmia is present. The superolateral bony deficiency of the orbits allows a lateral displacement of the globes. The lateral one-third of the upper eyelid and the outer canthus are distorted, thus preventing apposition to the globe. The upper eyelid does not have a true cleft. A soft tissue furrow radiates superiorly and posterisphenoid is symmetric and normal. Mild cranial base asymmetry is reflected in the pterygoid plates. The left pair is more laterally displaced from the midline. Skull vault plagiocephaly is evident with an apparent reduction in the anteroposterior dimension of the anterior cranial fossa.
http://purl.obolibrary.org/obo/HP_0031582	Tessier number 10 facial cleft	http://purl.obolibrary.org/obo/HP_0031574	Orbital cleft		In a Number 10 Tessier cleft there is an upper central orbital cleft with a cleft of the middle one-third of the upper eyelid, which often results in total ablepharia. The eyebrow is disrupted, being virtually absent medially, whereas the lateral portion angles upward toward the frontal hairline. There may be ocular anomalies, including colobomata of the iris. The skeletal cleft is through the midportion of the supraorbital rim, the adjacent frontal bone, and the orbital roof lateral to the supraorbital nerve. A frontal encephalocele frequently occupies the frontal bony cleft. The palpebral fissure is grossly elongated with an amblyopic eye displaced inferiorly and laterally. There is also a divergent squint of the right eye. The eyebrow is deficient medially and becomes thinned out laterally , where it is contiguous with a broad downward and forward projection of the frontotemporal hairline (this may be seen in both the Number 9 and 10 clefts.) A broad frontal encephalocele bulges forward from the middle one-third of the right forehead, supraorbital ridge, and orbital roof. The bony cleft, through which the frontal encephalocele presents, involves the anterior half of the orbital roof, the supraorbital rim, and two-thirds of the vertical height of the frontal bone lateral to the supraorbital nerve. The bony orbit is inferiorly displaced and widened with the lateral orbital wall shortened and laterally deviated. Similar distortion of the anterior cranial fossa is evident, being broader and more flattened on the affected side. The calvarium above the level of the cleft and the cranial base below is symmetric.
http://purl.obolibrary.org/obo/HP_0031583	Tessier number 11 facial cleft	http://purl.obolibrary.org/obo/HP_0031574	Orbital cleft		An upper medial orbital cleft produces a cleft of the medial one-third of the upper eyelid that extends through the eyebrow into the frontal hairline. The skeletal element of the cleft in the region of the frontal process of the maxilla may either pass lateral to the ethmoid, through the supraorbital rim, or it may pass through the ethmoidal labyrinth to produce orbital hypertelorism. This cleft usually accompanies the Number 3 cleft. The soft tissue features include a cleft of the medial portion of the upper eyelid, an irregularity in hair orientation at the medial end of the eyebrow, and a long tongue-like projection of the frontal hairline onto the forehead. There is a mild flattening of the frontal process of the maxilla and extensive pneumatization of both the ethmoidal and frontal sinuses, both of which are more prominent on the cleft side. No bony clefting of the supraorbital rim or frontal bone is evident. The cranial base and sphenoid architecture, including the pterygoid processes, are symmetric and normal.
http://purl.obolibrary.org/obo/HP_0031584	Tessier number 12 facial cleft	http://purl.obolibrary.org/obo/HP_0031571	Paramedian facial cleft		There is a soft tissue cleft medial to the inner canthus with a cleft of the root of the eyebrow. The frontal process of the maxilla is flat and broadened, and the ethmoid labyrinth is increased in transverse dimension, thereby producing orbital hypertelorism. The cribriform plate is of normal width. The frontal sinus is enlarged. Even though the frontal bone is flattened, bony clefts with encephalocele have not been observed. There is a lateral displacement of the inner canthus with a mild thinning, aplasia, or irregularity of the medial end of the eyebrow. There are no eyelid clefts. The soft tissue contour of the forehead is normal, with only a short downward prolongation of the paramedian frontal hairline to mark the superior extent of the soft tissue cleft. Flattening of the frontal process of the maxilla, an increase in the transverse dimension of the ethmoid sinus, and a laterally convex bowing of the medial orbital wall produce orbital hypertelorism. Superiorly there is a minor flattening of the frontal bone medially, and the nasofrontal angle is somewhat obtuse. The extensive pneumatization of the sinuses on the cleft side extends backward through the frontal and ethmoid sinuses and into the sphenoid sinus. The anatomy of the sphenoid, including the pterygoid processes, is otherwise normal. The anterior and middle cranial fossae floors are both broadened on the cleft side with minor widening of the cribriform plate.
http://purl.obolibrary.org/obo/HP_0031585	Tessier number 13 facial cleft	http://purl.obolibrary.org/obo/HP_0031571	Paramedian facial cleft		There is a paramedian frontal encephalocele and a soft tissue cleft that passes medial to an intact eyebrow. The frontal bone shows a paramedian bony cleft with an associated encephalocele. The olfactory groove, cribriform plate, and ethmoid sinus are all increased in transverse diameter, resulting in hypertelorism. The cleft extends medially to the undisturbed eyebrow to end in a short paramedian frontal widow's peak. The bony cleft begins in the region of the nasal bone and extends superiorly through the full height of the frontal bone. Posteriorly, the cleft extends through the cribriform plate and ethmoid sinus as far as the lesser wing and body of the sphenoid. The pterygoid processes are anatomically normal, but they are displaced laterally from the midline on the cleft side. There is orbital hypertelorism below and asymmetry of the floor of the anterior cranial fossa above.
http://purl.obolibrary.org/obo/HP_0031586	Tessier number 14 facial cleft	http://purl.obolibrary.org/obo/HP_0100629	Midline facial cleft		This midline cranial cleft usually occurs with a midline facial cleft that completes a median craniofacial dysraphia. A broad nasal root and bifid nose are associated with orbital hypertelorism and a median frontal encephalocele. The frontal bone abnormality varies from a minor flattening to a large midline defect. There is an increased distance between the olfactory grooves. The crista galli is widened, duplicated, or in some cases absent. Marked inferior prolapse of the enlarged ethmoid bone occurs with orbital hypertelorism. The severe orbital hypertelorism is associated with a broad flattening of the glabella and extreme lateral displacement of the inner canthi. The periorbita, including the eyelids and eyebrows, are otherwise normal. A long midline projection of the frontal hairline marks the superior extent of the soft tissue features of this midline cranial cleft. The median frontal defect delineates the region through which the frontal encephalocele herniates. The lateral segments of the frontal bone sweep upward from the region of the intact glabella and are flattened laterally. No pneumatization of the frontal sinus is evident. The crista galli and the perpendicular plate of the ethmoid are bifid. Just as the ethmoid, including the cribriform plate, is widened and caudally displaced, the sphenoid sinus is broadened and extensively, but symmetrically pneumatized. The lateral rotation of the greater and lesser wings of the sphenoid results in a relative shortening of the anteroposterior dimension of the middle cranial fossa. The floor of the anterior cranial fossa is upslanting from its medial aspect to its lateral aspect, with a harlequin appearance on the coronal scan.
http://purl.obolibrary.org/obo/HP_0031587	Tessier number 30 facial cleft	http://purl.obolibrary.org/obo/HP_0100629	Midline facial cleft		A lower midline facial cleft, also known as the median mandibular cleft. It is a rare anomaly, which may be limited to a defect in the soft tissue of the lower lip. However, in the more severe form, it may extend into the bony mandibular symphysis.
http://purl.obolibrary.org/obo/HP_0031588	Unhappy demeanor	http://purl.obolibrary.org/obo/HP_5200261	Abnormal demeanor		A noticeably unhappy disposition is characterized by negative assumptions, self-defeating talk, fear of failure, and negative rumination about past events.
http://purl.obolibrary.org/obo/HP_0031589	Suicidal ideation	http://purl.obolibrary.org/obo/HP_0025785	Abnormal preoccupation		Frequent thoughts about or preoccupation with killing oneself.
http://purl.obolibrary.org/obo/HP_0031590	Asthenopia	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		Eye strain, i.e., a feeling of fatigue or discomfort of the eyes related to 'overuse' of the eyes in activities such as reading or working at the computer and often accompanied by lacrimation or headache.
http://purl.obolibrary.org/obo/HP_0031591	Enlarged Eustachian valve	http://purl.obolibrary.org/obo/HP_0025576	Abnormal inferior vena cava morphology		An abnormally large Eustachian valve (postnatally). The Eustachian valve is also known as the valve of the inferior vena cava, and is an embryologic remnant of the valve of the inferior vena cava.
http://purl.obolibrary.org/obo/HP_0031592	Situs inversus with levocardia	http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments		Situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia.
http://purl.obolibrary.org/obo/HP_0031594	PR segment depression	http://purl.obolibrary.org/obo/HP_0031596	Abnormal PR segment		A reduction in voltage of the PR segment below baseline.
http://purl.obolibrary.org/obo/HP_0031595	Abnormal P wave	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		Any anomaly of the P wave of the EKG, which results from atrial depolarization. The P wave occurs when the sinoatrial node creates an action potential that depolarizes the atria.
http://purl.obolibrary.org/obo/HP_0031596	Abnormal PR segment	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		An anomaly of the PR segment, which begins at the endpoint of the P wave and ends at the onset of the QRS complex. The PR segment is normally flat and isoelectric.
http://purl.obolibrary.org/obo/HP_0031597	PR segment elevation	http://purl.obolibrary.org/obo/HP_0031596	Abnormal PR segment		An increase in voltage of the PR segment above baseline.
http://purl.obolibrary.org/obo/HP_0031598	Notched P wave	http://purl.obolibrary.org/obo/HP_0031595	Abnormal P wave		V-shaped cut (notch) in the middle of the P wave.
http://purl.obolibrary.org/obo/HP_0031599	P mitrale	http://purl.obolibrary.org/obo/HP_0031595	Abnormal P wave		A broad (120 ms or longer in duration) and bifid P-wave in EKG lead II.
http://purl.obolibrary.org/obo/HP_0031600	P wave inversion	http://purl.obolibrary.org/obo/HP_0031595	Abnormal P wave		P wave below instead of above the baseline. P-wave inversion in the inferior leads may indicate a non-sinus origin of the P waves.
http://purl.obolibrary.org/obo/HP_0031601	P pulmonale	http://purl.obolibrary.org/obo/HP_0031595	Abnormal P wave		The presence of tall, peaked P waves in EKG lead II.
http://purl.obolibrary.org/obo/HP_0031602	Abnormal mucociliary clearance	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		An anomaly in the system of mucociliary transport, which functions to transport the mucous layer lining the respiratory epithelium by ciliary beating.
http://purl.obolibrary.org/obo/HP_0031603	Impaired nasal mucociliary clearance	http://purl.obolibrary.org/obo/HP_0031602	Abnormal mucociliary clearance		An abnormally increased amount of time required to clear mucus (and substances contained in the mucus) from the nasal mucosa. The nasal mucociliary clearance (NMC) system functions to transport the mucous layer lining the nasal epithelium towards the naso pharynx by ciliary beating in a metachronous fashion at a frequency of 7-16 Hz. NMC depends upon two principal components: physicochemical qualities and quantities of mucus and the properties of cilia that propel it. NMC is considered to be representative of pulmonary clearance. normal NMC time is determined to be up to 20 minutes. Duration of 30 minutes is considered as the cutoff point that discriminates normal subjects from subjects with impaired NMC. NMC can be measured by determination of the transport time of markers that are placed on the nasal mucosa including saccharine, radioactive markers, and dyes.
http://purl.obolibrary.org/obo/HP_0031604	Agenesis of the carotid canal	http://purl.obolibrary.org/obo/HP_0009911	Abnormal temporal bone morphology		A developmental defect characterized by the lack of formation of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse.
http://purl.obolibrary.org/obo/HP_0031606	Retinal cotton wool spot	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Fluffy white patch in the inner retina, representing localized areas of dense white swelling of the retinal nerve fiber layer.
http://purl.obolibrary.org/obo/HP_0031607	Pelvic organ prolapse	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		Pelvic organ prolapse (POP) refers to the protrusion of one or more female pelvic organs outside the pelvis through the vagina including uterus, bladder and intestines, and causes the pelvic organs to drop downward to the vaginal wall. That is, POP is defined as the anatomical prolapse with descent of at least one of the vaginal walls to or beyond the vaginal hymen with maximal Valsalva effort with the presence either of bothersome characteristic symptoms, most commonly the sensation of vaginal bulge, or of functional or medical compromise due to prolapse without symptom bother.
http://purl.obolibrary.org/obo/HP_0031609	Macular geographic atrophy	http://purl.obolibrary.org/obo/HP_0001105	Retinal atrophy		Chronic progressive degeneration of the macula that can be seen as part of late-stage age-related macular degeneration (AMD).
http://purl.obolibrary.org/obo/HP_0031610	Recurrent shoulder dislocation	http://purl.obolibrary.org/obo/HP_0031869	Recurrent joint dislocation		Shoulder dislocation occurring repeated times.
http://purl.obolibrary.org/obo/PATO_0045032	normal mobility	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A mobility which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045050	normal size	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A size quality which is relatively normal or average
http://purl.obolibrary.org/obo/HP_0032016	Abnormal sputum	http://purl.obolibrary.org/obo/HP_0012252	Abnormal respiratory system morphology		Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin.
http://purl.obolibrary.org/obo/HP_0020064	Abnormal total eosinophil count	http://purl.obolibrary.org/obo/HP_0032309	Abnormal granulocyte count		Abnormal increase or decrease of absolute number of eosinophils in the blood, per microlitre, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032101	Unusual infection	http://purl.obolibrary.org/obo/HP_0010978	Abnormality of immune system physiology		Increased susceptibility to infection, as manifested by recurrent infection, severe or invasive infection, infection occurring in an unusual anatomical location, or infection with opportunistic organisms, that is unusual for a healthy individual of the same age.
http://purl.obolibrary.org/obo/HP_0032135	Decreased circulating IgG subclass concentration	http://purl.obolibrary.org/obo/HP_0004315	Decreased circulating IgG concentration		A reduction below the normal concentration of a subclass of immunoglobulin G (IgG) in the blood.
http://purl.obolibrary.org/obo/HP_0032148	Episodic pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		Intermittent pain, i.e., pain that occurs occasionally and at irregular intervals.
http://purl.obolibrary.org/obo/HP_0032153	Joint subluxation	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		A partial dislocation of a joint.
http://purl.obolibrary.org/obo/HP_0410240	Abnormal circulating IgA concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		An abnormal deviation from normal levels of IgA immunoglobulin in blood.
http://purl.obolibrary.org/obo/HP_0410241	Abnormal circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		An abnormal deviation from normal levels of IgE immunoglobulin in blood.
http://purl.obolibrary.org/obo/HP_0410242	Abnormal circulating IgG concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		An abnormal deviation from normal levels of IgG immunoglobulin in blood.
http://purl.obolibrary.org/obo/HP_0410280	Pediatric onset	http://purl.obolibrary.org/obo/HP_0003674	Onset		Onset of disease manifestations before adulthood, defined here as before the age of 16 years, but excluding neonatal or congenital onset.
http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Any deviation of the concentration of one or more proteins in the urine.
http://purl.obolibrary.org/obo/HP_0020131	Abnormal tubular basement membrane morphology	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Abnormal structure of the basement membrane of the renal tubulus.
http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure	http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure		A focal cognitive seizure involves an alteration in a cognitive function (which can be a deficit or a positive phenomenon such as forced thought), which occurs at seizure onset. To be classified as a focal cognitive seizure, the change in cognitive function should be specific and out of proportion to other relatively unimpaired aspects of cognition, because all cognition is impaired in a focal impaired awareness seizure.
http://purl.obolibrary.org/obo/HP_0032681	Focal aware cognitive seizure	http://purl.obolibrary.org/obo/HP_0032682	Focal aware non-motor seizure		A focal aware cognitive seizure during which awareness is retained throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032682	Focal aware non-motor seizure	http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure		A focal non-motor seizure in which awareness is retained throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032684	Focal aware cognitive seizure with auditory agnosia	http://purl.obolibrary.org/obo/HP_0032685	Focal cognitive seizure with auditory agnosia		A focal cognitive seizure with auditory agnosia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032685	Focal cognitive seizure with auditory agnosia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by auditory agnosia as the initial semiological manifestation. For example a person may hear a ringing sound, but may not connect this with the concept that the sound is from a telephone ringing.
http://purl.obolibrary.org/obo/HP_0032686	Focal aware cognitive seizure with memory impairment	http://purl.obolibrary.org/obo/HP_0032687	Focal cognitive seizure with memory impairment		A focal cognitive seizure with memory impairment characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032687	Focal cognitive seizure with memory impairment	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by transient memory impairment as the initial semiological manifestation whilst other cognitive functions and awareness are preserved at seizure onset. The memory impairment may be an inability to recall events occurring prior to the seizure (retrograde amnesia), or failure to encode new memories for events occurring during the seizure (anterograde amnesia).
http://purl.obolibrary.org/obo/HP_0032688	Focal aware cognitive seizure with dissociation	http://purl.obolibrary.org/obo/HP_0032689	Focal cognitive seizure with dissociation		A focal cognitive seizure with dissociation characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032689	Focal cognitive seizure with dissociation	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by an experience of being disconnected from, though aware of, self or environment as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032690	Focal aware cognitive seizure with dyscalculia/acalculia	http://purl.obolibrary.org/obo/HP_0032691	Focal cognitive seizure with dyscalculia/acalculia		A focal cognitive seizure with dyscalculia and or acalculia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032691	Focal cognitive seizure with dyscalculia/acalculia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by dyscalculia / acalculia as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032692	Focal cognitive seizure with forced thinking	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by forced thinking as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032693	Focal cognitive seizure with neglect	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by neglect as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032694	Focal cognitive seizure with dyslexia/alexia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by dyslexia / alexia as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032696	Focal cognitive seizure with receptive dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by receptive dysphasia / aphasia as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032698	Focal cognitive seizure with conduction dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by conduction dysphasia / aphasia as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032699	Focal cognitive seizure with dysgraphia/agraphia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by dysgraphia / agraphia as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032700	Focal cognitive seizure with left-right confusion	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by left-right confusion as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032701	Focal cognitive seizure with anomia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by anomia as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032702	Focal cognitive seizure with expressive dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032680	Focal cognitive seizure		A focal cognitive seizure characterized by expressive dysphasia / aphasia as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032704	Focal aware cognitive seizure with illusion	http://purl.obolibrary.org/obo/HP_0032681	Focal aware cognitive seizure		A focal cognitive seizure with illusion characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032705	Focal aware cognitive seizure with forced thinking	http://purl.obolibrary.org/obo/HP_0032692	Focal cognitive seizure with forced thinking		A focal cognitive seizure with forced thinking characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032706	Focal aware cognitive seizure with left-right confusion	http://purl.obolibrary.org/obo/HP_0032700	Focal cognitive seizure with left-right confusion		A focal cognitive seizure with left-right confusion characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032707	Focal aware cognitive seizure with dyslexia/alexia	http://purl.obolibrary.org/obo/HP_0032694	Focal cognitive seizure with dyslexia/alexia		A focal cognitive seizure with dyslexia / alexia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032708	Focal aware cognitive seizure with anomia	http://purl.obolibrary.org/obo/HP_0032701	Focal cognitive seizure with anomia		A focal cognitive seizure with anomia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032709	Focal aware cognitive seizure with dysgraphia/agraphia	http://purl.obolibrary.org/obo/HP_0032699	Focal cognitive seizure with dysgraphia/agraphia		A focal cognitive seizure with dysgraphia / agraphia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032710	Focal aware cognitive seizure with receptive dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032696	Focal cognitive seizure with receptive dysphasia/aphasia		A focal cognitive seizure with receptive dysphasia / aphasia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032711	Focal aware clonic seizure	http://purl.obolibrary.org/obo/HP_0020217	Focal aware motor seizure		A type of focal clonic seizure during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032712	Focal impaired awareness motor seizure	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A type of focal motor seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032713	Focal impaired awareness motor seizure with version	http://purl.obolibrary.org/obo/HP_0032712	Focal impaired awareness motor seizure		A focal motor seizure with version characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032714	Focal impaired awareness bilateral motor seizure	http://purl.obolibrary.org/obo/HP_0032715	Focal bilateral motor seizure		A focal bilateral motor seizure characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032715	Focal bilateral motor seizure	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A type of focal motor seizure (it commences in one hemisphere) involving bilateral muscle groups rapidly at seizure onset.
http://purl.obolibrary.org/obo/HP_0032716	Focal impaired awareness non-motor seizure	http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure		A focal non-motor seizure characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032717	Focal impaired awareness motor seizure with dystonia	http://purl.obolibrary.org/obo/HP_0032718	Focal motor seizure with dystonia		A focal motor seizure with dystonia characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032718	Focal motor seizure with dystonia	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A focal motor seizure in which the initial semiological manifestation is the sustained contraction of both agonist and antagonist muscles producing athetoid or twisting movements, which produces abnormal postures.
http://purl.obolibrary.org/obo/HP_0032719	Focal impaired awareness motor seizure with dysarthria/anarthria	http://purl.obolibrary.org/obo/HP_0032720	Focal motor seizure with dysarthria/anarthria		A focal motor seizure with dysarthria / anarthria characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032720	Focal motor seizure with dysarthria/anarthria	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A type of focal motor seizure characterized by difficulty with articulation of speech, due to impaired coordination of muscles involved in speech sound production as the initial semiological manifestation. Receptive and expressive language functions are intact, however speech is poorly articulated and is less intelligible.
http://purl.obolibrary.org/obo/HP_0032721	Focal motor seizure with paresis/paralysis	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A focal motor seizure characterized by weakness or complete paralysis of a muscle or group of muscles as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0032722	Focal aware tonic seizure	http://purl.obolibrary.org/obo/HP_0020217	Focal aware motor seizure		A type of focal tonic seizure during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032723	Focal aware motor seizure with dystonia	http://purl.obolibrary.org/obo/HP_0032718	Focal motor seizure with dystonia		A focal motor seizure with dystonia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032724	Focal impaired awareness tonic seizure	http://purl.obolibrary.org/obo/HP_0032712	Focal impaired awareness motor seizure		A focal tonic seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032725	Focal impaired awareness clonic seizure	http://purl.obolibrary.org/obo/HP_0032712	Focal impaired awareness motor seizure		A type of focal clonic seizure during which awareness is partially or fully impaired at some point in the seizure.
http://purl.obolibrary.org/obo/HP_0032726	Focal impaired awareness hyperkinetic seizure	http://purl.obolibrary.org/obo/HP_0032712	Focal impaired awareness motor seizure		A focal hyperkinetic seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032727	Focal emotional seizure with agitation	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		Focal emotional seizure with agitation is characterized by the presence of psychomotor agitation as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures.
http://purl.obolibrary.org/obo/HP_0032728	Focal impaired awareness atonic seizure	http://purl.obolibrary.org/obo/HP_0032712	Focal impaired awareness motor seizure		A focal atonic seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032729	Focal emotional seizure with pleasure	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		Focal emotional seizure with pleasure is characterized by the presence of a positive emotional experience with pleasure, bliss, joy, enhanced personal well-being, heightened self-awareness or ecstasy.
http://purl.obolibrary.org/obo/HP_0032730	Focal impaired awareness myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032712	Focal impaired awareness motor seizure		A focal myoclonic seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032731	Focal aware hyperkinetic seizure	http://purl.obolibrary.org/obo/HP_0020217	Focal aware motor seizure		A type of focal hypermotor seizure during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032732	Focal aware motor seizure with paresis/paralysis	http://purl.obolibrary.org/obo/HP_0032721	Focal motor seizure with paresis/paralysis		A focal motor seizure with paresis / paralysis characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032733	Focal aware motor seizure with dysarthria/anarthria	http://purl.obolibrary.org/obo/HP_0032720	Focal motor seizure with dysarthria/anarthria		A focal motor seizure with dysarthria / anarthria characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032734	Focal aware emotional seizure	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		A focal emotional seizure during which awareness is retained throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032735	Focal aware emotional seizure with anger	http://purl.obolibrary.org/obo/HP_0032736	Focal emotional seizure with anger		Focal emotional seizure with anger in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032736	Focal emotional seizure with anger	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		Focal emotional seizure with anger is characterized by the presence of anger, as an expressed or observed emotion, at the outset of the seizure. It may be accompanied by aggressive behavior.
http://purl.obolibrary.org/obo/HP_0032737	Focal emotional seizure with paranoia	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		Focal emotional seizure with paranoia is characterized by the presence of paranoia as an expressed or observed emotion at the outset of the seizure.
http://purl.obolibrary.org/obo/HP_0032738	Focal aware emotional seizure with fear/anxiety/panic	http://purl.obolibrary.org/obo/HP_0032739	Focal emotional seizure with fear/anxiety/panic		Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032739	Focal emotional seizure with fear/anxiety/panic	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		Focal emotional seizure with anxiety is characterized by the presence of anxiety, fear or panic as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures.
http://purl.obolibrary.org/obo/HP_0032740	Focal aware autonomic seizure	http://purl.obolibrary.org/obo/HP_0032682	Focal aware non-motor seizure		A focal aware autonomic seizure has an initial manifestation pertaining to autonomic nervous system function, which may be objective (for example, pupillary dilation) or subjective (for example, nausea). As a type of focal aware seizure, awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032741	Focal aware emotional seizure with paranoia	http://purl.obolibrary.org/obo/HP_0032737	Focal emotional seizure with paranoia		Focal emotional seizure with paranoia in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032742	Focal aware emotional seizure with pleasure	http://purl.obolibrary.org/obo/HP_0032734	Focal aware emotional seizure		Focal emotional seizure with pleasure in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032743	Focal aware emotional seizure with crying	http://purl.obolibrary.org/obo/HP_0032734	Focal aware emotional seizure		Focal emotional seizure with crying (dacrystic)in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032744	Focal aware emotional seizure with agitation	http://purl.obolibrary.org/obo/HP_0032734	Focal aware emotional seizure		Focal emotional seizure with agitation in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032745	Focal aware emotional seizure with laughing	http://purl.obolibrary.org/obo/HP_0032734	Focal aware emotional seizure		Focal emotional seizure with laughing in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure	http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure		A focal emotional seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032747	Focal impaired awareness emotional seizure with pleasure	http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure		Focal emotional seizure with pleasure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032748	Focal impaired awareness emotional seizure with anger	http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure		Focal emotional seizure with anger in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032749	Focal impaired awareness emotional seizure with paranoia	http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure		Focal emotional seizure with paranoia in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032750	Focal impaired awareness emotional seizure with laughing	http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure		Focal emotional seizure with laughing in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032751	Focal impaired awareness emotional seizure with crying	http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure		Focal emotional seizure with crying in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032752	Focal impaired awareness emotional seizure with fear/anxiety/panic	http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure		Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032753	Focal impaired awareness emotional seizure with agitation	http://purl.obolibrary.org/obo/HP_0032746	Focal impaired awareness emotional seizure		A focal emotional seizure with agitation in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032754	Focal aware sensory seizure	http://purl.obolibrary.org/obo/HP_0032682	Focal aware non-motor seizure		A focal sensory seizure during which awareness is retained throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032755	Focal impaired awareness autonomic seizure	http://purl.obolibrary.org/obo/HP_0032716	Focal impaired awareness non-motor seizure		A focal autonomic seizure characterized by impaired awareness at some point within the seizure.
http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure	http://purl.obolibrary.org/obo/HP_0032716	Focal impaired awareness non-motor seizure		A focal cognitive seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032757	Focal aware hemiclonic seizure	http://purl.obolibrary.org/obo/HP_0032711	Focal aware clonic seizure		A focal hemiclonic seizure in which awareness is retained throughout.
http://purl.obolibrary.org/obo/HP_0032758	Focal aware myoclonic seizure	http://purl.obolibrary.org/obo/HP_0020217	Focal aware motor seizure		A type of focal myoclonic seizure during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032759	Focal sensory seizure with vestibular features	http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure		A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0032760	Focal sensory seizure with hot-cold sensations	http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure		A seizure characterized by sensations of feeling hot or cold as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0032761	Focal aware autonomic seizure with pallor/flushing	http://purl.obolibrary.org/obo/HP_0032762	Focal autonomic seizure with pallor/flushing		A focal autonomic seizure with pallor / flushing characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032762	Focal autonomic seizure with pallor/flushing	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by changes of the skin as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032763	Focal autonomic seizure with pupillary dilation/constriction	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by pupillary dilatation or contraction as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032764	Focal autonomic seizure with erection	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by penile erection as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032765	Focal autonomic seizure with urge to urinate/defecate	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by an urge to unripe or defecate as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032766	Focal autonomic seizure with hypoventilation/hyperventilation/altered respiration	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by changes in respiratory rate as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032767	Focal autonomic seizure with piloerection	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032768	Focal aware autonomic seizure with pupillary dilation/constriction	http://purl.obolibrary.org/obo/HP_0032763	Focal autonomic seizure with pupillary dilation/constriction		A focal autonomic seizure with pupillary dilation / constriction characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032769	Focal aware autonomic seizure with hypoventilation/hyperventilation/altered respiration	http://purl.obolibrary.org/obo/HP_0032766	Focal autonomic seizure with hypoventilation/hyperventilation/altered respiration		An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032770	Focal aware autonomic seizure with erection	http://purl.obolibrary.org/obo/HP_0032764	Focal autonomic seizure with erection		A focal autonomic seizure with erection characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032771	Focal autonomic seizure with lacrimation	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by lacrimation as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032772	Focal impaired awareness autonomic seizure with piloerection	http://purl.obolibrary.org/obo/HP_0032767	Focal autonomic seizure with piloerection		A Focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032773	Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole	http://purl.obolibrary.org/obo/HP_0011154	Focal autonomic seizure		A type of focal autonomic seizure characterized by changes in heart rate as the initial semiological feature.
http://purl.obolibrary.org/obo/HP_0032774	Focal impaired awareness autonomic seizure with urge to urinate/defecate	http://purl.obolibrary.org/obo/HP_0032765	Focal autonomic seizure with urge to urinate/defecate		A focal autonomic seizure with urge to urinate / defecate characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032775	Focal impaired awareness autonomic seizure with hypoventilation/hyperventilation/altered respiration	http://purl.obolibrary.org/obo/HP_0032766	Focal autonomic seizure with hypoventilation/hyperventilation/altered respiration		An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032777	Focal impaired awareness autonomic seizure with pallor/flushing	http://purl.obolibrary.org/obo/HP_0032762	Focal autonomic seizure with pallor/flushing		A focal autonomic seizure with pallor / flushing characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032778	Focal impaired awareness autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena	http://purl.obolibrary.org/obo/HP_0032755	Focal impaired awareness autonomic seizure		A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032779	Focal impaired awareness autonomic seizure with pupillary dilation/constriction	http://purl.obolibrary.org/obo/HP_0032763	Focal autonomic seizure with pupillary dilation/constriction		A focal autonomic seizure with pupillary dilation / constriction characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032780	Focal impaired awareness autonomic seizure with erection	http://purl.obolibrary.org/obo/HP_0032764	Focal autonomic seizure with erection		A focal autonomic seizure with erection characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032781	Focal aware autonomic seizure with urge to urinate/defecate	http://purl.obolibrary.org/obo/HP_0032765	Focal autonomic seizure with urge to urinate/defecate		A focal autonomic seizure with urge to urinate / defecate characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032782	Focal impaired awareness autonomic seizure with lacrimation	http://purl.obolibrary.org/obo/HP_0032771	Focal autonomic seizure with lacrimation		A focal autonomic seizure with lacrimation characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032783	Focal aware autonomic seizure with piloerection	http://purl.obolibrary.org/obo/HP_0032767	Focal autonomic seizure with piloerection		A focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032784	Focal aware autonomic seizure with palpitations/tachycardia/bradycardia/asystole	http://purl.obolibrary.org/obo/HP_0032773	Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole		An autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032785	Focal aware autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena	http://purl.obolibrary.org/obo/HP_0032740	Focal aware autonomic seizure		A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032786	Migrating focal seizure	http://purl.obolibrary.org/obo/HP_0007359	Focal-onset seizure		A migrating focal seizure is a seizure that involves different body parts, usually without overlap, in a consecutive manner so that the offset of a seizure in one part coincides with its onset in another, even shifting multiple times between the sides of the body. They can be associated with autonomic manifestations.
http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure	http://purl.obolibrary.org/obo/HP_0032716	Focal impaired awareness non-motor seizure		A focal sensory seizure in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032788	Focal impaired awareness autonomic seizure with palpitations/tachycardia/bradycardia/asystole	http://purl.obolibrary.org/obo/HP_0032773	Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole		A focal autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032789	Focal aware behavior arrest seizure	http://purl.obolibrary.org/obo/HP_0032682	Focal aware non-motor seizure		A focal behavior arrest seizure characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032790	Focal impaired awareness behavior arrest seizure	http://purl.obolibrary.org/obo/HP_0032716	Focal impaired awareness non-motor seizure		A focal behavior arrest seizure characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032791	Focal impaired awareness cognitive seizure with anomia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with anomia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032793	Focal impaired awareness cognitive seizure with receptive dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with receptive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032795	Generalized myoclonic-tonic-clonic seizure	http://purl.obolibrary.org/obo/HP_0032677	Generalized-onset motor seizure		A generalized myoclonic-tonic-clonic seizure is a type of generalized motor seizure characterized by a single or multiple jerks of limbs bilaterally, followed by tonic and clonic phases. The initial jerks can be considered to be either a brief period of clonus or myoclonus.
http://purl.obolibrary.org/obo/HP_0032796	Focal impaired awareness cognitive seizure with left-right confusion	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with left-right confusion characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032797	Focal aware sensory seizure with olfactory features	http://purl.obolibrary.org/obo/HP_0032754	Focal aware sensory seizure		Seizures characterized by olfactory phenomena at onset - usually an odor, which is often unpleasant.
http://purl.obolibrary.org/obo/HP_0032798	Focal impaired awareness cognitive seizure with neglect	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with neglect characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032799	Focal impaired awareness hemiclonic seizure	http://purl.obolibrary.org/obo/HP_0032725	Focal impaired awareness clonic seizure		A focal hemiclonic seizure in which awareness is impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032800	Focal aware sensory seizure with vestibular features	http://purl.obolibrary.org/obo/HP_0032759	Focal sensory seizure with vestibular features		A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation.
http://purl.obolibrary.org/obo/HP_0032801	Focal impaired awareness cognitive seizure with memory impairment	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with memory impairment characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032802	Focal impaired awareness cognitive seizure with dyscalculia/acalculia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with dyscalculia / acalculia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032803	Focal impaired awareness cognitive seizure with dysgraphia/agraphia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with dysgraphia / agraphia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032804	Focal impaired awareness sensory seizure with olfactory features	http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure		A focal sensory seizure with olfaction in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032805	Focal impaired awareness sensory seizure with vestibular features	http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure		A focal sensory seizure with vestibular features in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032806	Focal impaired awareness sensory seizure with visual features	http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure		A focal sensory seizure with visual features in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032807	Neonatal seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		A seizure occurring within the neonatal period (28 days beyond the full term date).
http://purl.obolibrary.org/obo/HP_0032808	Neonatal seizure with electrographic correlate	http://purl.obolibrary.org/obo/HP_0032807	Neonatal seizure		Neonatal seizure is a seizure type that occurs in neonatal period and is characterized by an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end. This event can be associated or not with a clinical manifestation.
http://purl.obolibrary.org/obo/HP_0032809	Neonatal electro-clinical seizure	http://purl.obolibrary.org/obo/HP_0032808	Neonatal seizure with electrographic correlate		Neonatal electro-clinical seizure is an electrographic event occurring in neonatal period and coupled with a clinical manifestation.
http://purl.obolibrary.org/obo/HP_0032810	Focal sensory seizure with cephalic sensation	http://purl.obolibrary.org/obo/HP_0011157	Focal sensory seizure		A seizure characterized by a sensation in the head such as light-headedness or headache as its first clinical manifestation.
http://purl.obolibrary.org/obo/HP_0032811	Neonatal electrographic only seizure	http://purl.obolibrary.org/obo/HP_0032808	Neonatal seizure with electrographic correlate		Neonatal electrographic only seizure is an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end, which is not associated with a clinical manifestation.
http://purl.obolibrary.org/obo/HP_0032813	Neonatal electro-clinical motor seizure	http://purl.obolibrary.org/obo/HP_0032809	Neonatal electro-clinical seizure		Neonatal electro-clinical motor seizure is a type of neonatal electro-clinical seizure with predominant motor features.
http://purl.obolibrary.org/obo/HP_0032814	Neonatal electro-clinical clonic seizure	http://purl.obolibrary.org/obo/HP_0032813	Neonatal electro-clinical motor seizure		Neonatal electro-clinical clonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups; it can be symmetric or asymmetric.
http://purl.obolibrary.org/obo/HP_0032815	Neonatal electro-clinical myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032813	Neonatal electro-clinical motor seizure		Neonatal electro-clinical myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal).
http://purl.obolibrary.org/obo/HP_0032816	Neonatal multifocal myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032815	Neonatal electro-clinical myoclonic seizure		Neonatal multifocal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) that occurs at multiple sites.
http://purl.obolibrary.org/obo/HP_0032817	Neonatal focal myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032815	Neonatal electro-clinical myoclonic seizure		Neonatal focal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) which occurs focally.
http://purl.obolibrary.org/obo/HP_0032818	Neonatal focal clonic seizure	http://purl.obolibrary.org/obo/HP_0032814	Neonatal electro-clinical clonic seizure		Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is unilateral regularly repeating jerking involving the same muscle groups.
http://purl.obolibrary.org/obo/HP_0032819	Neonatal bilateral clonic seizure	http://purl.obolibrary.org/obo/HP_0032814	Neonatal electro-clinical clonic seizure		Neonatal bilateral clonic seizure is a type of neonatal electro-clinical clonic seizure where the clonic jerking is bilateral.
http://purl.obolibrary.org/obo/HP_0032820	Neonatal multifocal clonic seizure	http://purl.obolibrary.org/obo/HP_0032814	Neonatal electro-clinical clonic seizure		Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups, which occurs at multiple sites.
http://purl.obolibrary.org/obo/HP_0032821	Neonatal electro-clinical tonic seizure	http://purl.obolibrary.org/obo/HP_0032813	Neonatal electro-clinical motor seizure		Neonatal electro-clinical tonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a sustained increase in muscle tone, usually focal, that can be unilateral or bilateral, and lasting a few seconds to minutes.
http://purl.obolibrary.org/obo/HP_0032822	Neonatal electro-clinical autonomic seizure	http://purl.obolibrary.org/obo/HP_0032812	Neonatal electro-clinical non-motor seizure		Neonatal electro-clinical non-motor autonomic seizure is a type of neonatal electro-clinical seizure with predominant features of autonomic alterations, involving cardiovascular, pupillary, gastrointestinal, sudomotor, vasomotor, and thermoregulatory functions. May present as apnea.
http://purl.obolibrary.org/obo/HP_0032823	Neonatal electro-clinical seizure with behavior arrest	http://purl.obolibrary.org/obo/HP_0032812	Neonatal electro-clinical non-motor seizure		Neonatal electro-clinical non-motor seizure with behavior arrest is a type of neonatal electro-clinical seizure characterized by an arrest of activities, freezing, immobilization, with or without apnea and/or other autonomic manifestations.
http://purl.obolibrary.org/obo/HP_0032824	Neonatal focal tonic seizure	http://purl.obolibrary.org/obo/HP_0032821	Neonatal electro-clinical tonic seizure		Neonatal focal tonic seizure is a type of neonatal electro-clinical tonic seizure with a focal sustained increase in muscle tone, lasting a few seconds to minutes.
http://purl.obolibrary.org/obo/HP_0032825	Neonatal electro-clinical sequential seizure	http://purl.obolibrary.org/obo/HP_0032809	Neonatal electro-clinical seizure		Neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic signs, often changing lateralization within or between seizures.
http://purl.obolibrary.org/obo/HP_0032826	Focal neonatal sequential seizure	http://purl.obolibrary.org/obo/HP_0032825	Neonatal electro-clinical sequential seizure		Focal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic focal signs, often changing lateralization within or between seizures.
http://purl.obolibrary.org/obo/HP_0032827	Multifocal neonatal sequential seizure	http://purl.obolibrary.org/obo/HP_0032825	Neonatal electro-clinical sequential seizure		Multifocal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic multifocal signs.
http://purl.obolibrary.org/obo/HP_0032828	Neonatal bilateral symmetric tonic seizure	http://purl.obolibrary.org/obo/HP_0032821	Neonatal electro-clinical tonic seizure		Neonatal bilateral symmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body symmetrically.
http://purl.obolibrary.org/obo/HP_0032829	Neonatal electro-clinical motor seizure with automatism	http://purl.obolibrary.org/obo/HP_0032813	Neonatal electro-clinical motor seizure		Neonatal electro-clinical motor seizure with automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awareness, and in association with other features.
http://purl.obolibrary.org/obo/HP_0032830	Neonatal seizure with bilateral asymmetric automatism	http://purl.obolibrary.org/obo/HP_0032829	Neonatal electro-clinical motor seizure with automatism		Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with coordinated motor activity, typically oral, usually with impaired awareness, occurring at both sides of the body asymmetrically.
http://purl.obolibrary.org/obo/HP_0032831	Neonatal bilateral asymmetric tonic seizure	http://purl.obolibrary.org/obo/HP_0032821	Neonatal electro-clinical tonic seizure		Neonatal bilateral asymmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body but asymmetrically.
http://purl.obolibrary.org/obo/HP_0032832	Neonatal bilateral asymmetric myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032815	Neonatal electro-clinical myoclonic seizure		Neonatal bilateral asymmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) that occurs at both sides of the body asymmetrically.
http://purl.obolibrary.org/obo/HP_0032833	Neonatal epileptic spasm	http://purl.obolibrary.org/obo/HP_0032813	Neonatal electro-clinical motor seizure		A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: grimacing, head nodding, or subtle eye movements. May occur in clusters.
http://purl.obolibrary.org/obo/HP_0032834	Neonatal seizure with unilateral automatism	http://purl.obolibrary.org/obo/HP_0032829	Neonatal electro-clinical motor seizure with automatism		Neonatal seizure with bilateral asymmetric automatisms is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awareness, occurring at one side of the body.
http://purl.obolibrary.org/obo/HP_0032835	Neonatal seizure with bilateral symmetric automatism	http://purl.obolibrary.org/obo/HP_0032829	Neonatal electro-clinical motor seizure with automatism		Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awareness, occurring at both sides of the body symmetrically.
http://purl.obolibrary.org/obo/HP_0032836	Neonatal bilateral symmetric myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032815	Neonatal electro-clinical myoclonic seizure		Neonatal bilateral symmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) that occurs at both sides of the body symmetrically.
http://purl.obolibrary.org/obo/HP_0032837	Bilateral asymmetric neonatal sequential seizure	http://purl.obolibrary.org/obo/HP_0032825	Neonatal electro-clinical sequential seizure		Asymmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting asymmetrically with a variety of clinical and electrographic signs, often changing lateralization within or between seizures.
http://purl.obolibrary.org/obo/HP_0032838	Neonatal unilateral epileptic spasm	http://purl.obolibrary.org/obo/HP_0032833	Neonatal epileptic spasm		Neonatal unilateral epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs at one side of the body.
http://purl.obolibrary.org/obo/HP_0032839	Bilateral symmetric neonatal sequential seizure	http://purl.obolibrary.org/obo/HP_0032825	Neonatal electro-clinical sequential seizure		Symmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting symmetrically but with a variety of clinical and electrographic signs.
http://purl.obolibrary.org/obo/HP_0032840	Neonatal bilateral symmetric epileptic spasm	http://purl.obolibrary.org/obo/HP_0032833	Neonatal epileptic spasm		Neonatal bilateral symmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs symmetrically at both sides of the body.
http://purl.obolibrary.org/obo/HP_0032841	Neonatal bilateral asymmetric epileptic spasm	http://purl.obolibrary.org/obo/HP_0032833	Neonatal epileptic spasm		Neonatal bilateral asymmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs asymmetrically at both sides of the body.
http://purl.obolibrary.org/obo/HP_0032842	Generalized-onset epileptic spasm	http://purl.obolibrary.org/obo/HP_0032677	Generalized-onset motor seizure		A type of epileptic spasm of generalized onset.
http://purl.obolibrary.org/obo/HP_0032843	Focal-onset epileptic spasm	http://purl.obolibrary.org/obo/HP_0011097	Epileptic spasm		A type of epileptic spasm of focal onset.
http://purl.obolibrary.org/obo/HP_0032844	Focal impaired awareness epileptic spasm	http://purl.obolibrary.org/obo/HP_0032843	Focal-onset epileptic spasm		A type of focal-onset epileptic spasm in which awareness is impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032845	Focal aware epileptic spasm	http://purl.obolibrary.org/obo/HP_0032843	Focal-onset epileptic spasm		A type of focal-onset epileptic spasm in which awareness is preserved throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032846	Focal motor seizure with negative myoclonus	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A type of focal motor seizure characterized by a sudden interruption in normal tonic muscle activity lasting 500 ms or less, without evidence of preceding myoclonus as the initial semiological manifestation. The interruption in muscle tone is briefer than seen in a focal atonic seizure.
http://purl.obolibrary.org/obo/HP_0032847	Focal impaired awareness hemifacial clonic seizure	http://purl.obolibrary.org/obo/HP_0032725	Focal impaired awareness clonic seizure		Focal seizure characterized at onset by clonic movements affecting half of the face with impairment of awareness in which awareness is impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032848	Focal aware cognitive seizure with neglect	http://purl.obolibrary.org/obo/HP_0032693	Focal cognitive seizure with neglect		A focal cognitive seizure with neglect characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032849	Aphasic status epilepticus	http://purl.obolibrary.org/obo/HP_0032673	Focal non-convulsive status epilepticus without coma		Aphasic status epilepticus is a type of focal non-convulsive status epilepticus without coma characterized by a cognitive (rather than motor) language deficit.
http://purl.obolibrary.org/obo/HP_0032850	Focal aware cognitive seizure with expressive dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032702	Focal cognitive seizure with expressive dysphasia/aphasia		A focal cognitive seizure with expressive dysphasia / aphasia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032851	Focal aware sensory seizure with visual features	http://purl.obolibrary.org/obo/HP_0032754	Focal aware sensory seizure		A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colors, or other shapes, simple patterns, scotomata, or amaurosis.
http://purl.obolibrary.org/obo/HP_0032852	Focal impaired awareness cognitive seizure with conduction dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with conduction dysphasia / aphasia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032853	Focal impaired awareness sensory seizure with hot-cold sensations	http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure		A focal sensory seizure with hot-cold sensations in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032854	Focal aware hemifacial clonic seizure	http://purl.obolibrary.org/obo/HP_0032711	Focal aware clonic seizure		Focal seizure characterized at onset by clonic movements affecting half of the face with retained awareness throughout.
http://purl.obolibrary.org/obo/HP_0032855	Photosensitive myoclonic-tonic-clonic seizure	http://purl.obolibrary.org/obo/HP_0032795	Generalized myoclonic-tonic-clonic seizure		Generalised myoclonic-tonic-clonic seizure provoked by flashing or flickering light.
http://purl.obolibrary.org/obo/HP_0032856	Focal aware bilateral motor seizure	http://purl.obolibrary.org/obo/HP_0032715	Focal bilateral motor seizure		A type of focal bilateral motor seizure during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032857	Focal aware motor seizure with negative myoclonus	http://purl.obolibrary.org/obo/HP_0032846	Focal motor seizure with negative myoclonus		A focal motor seizure with negative myoclonus characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032858	Focal impaired awareness motor seizure with negative myoclonus	http://purl.obolibrary.org/obo/HP_0032846	Focal motor seizure with negative myoclonus		A focal motor seizure with negative myoclonus characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032859	Focal impaired awareness motor seizure with paresis/paralysis	http://purl.obolibrary.org/obo/HP_0032721	Focal motor seizure with paresis/paralysis		A focal motor seizure with paresis / paralysis characterized by impaired awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032861	Focal non-convulsive status epilepticus with impairment of consciousness	http://purl.obolibrary.org/obo/HP_0032673	Focal non-convulsive status epilepticus without coma		Focal non-convulsive status epilepticus with impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness is impaired.
http://purl.obolibrary.org/obo/HP_0032862	Status epilepticus with ictal paresis	http://purl.obolibrary.org/obo/HP_0032663	Focal motor status epilepticus		A type of focal motor status epilepticus characterized by prolonged ictal paresis or inhibitory motor seizures.
http://purl.obolibrary.org/obo/HP_0032863	Typical absence status epilepticus	http://purl.obolibrary.org/obo/HP_0032860	Generalized non-convulsive status epilepticus without coma		Typical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged typical absence seizure.
http://purl.obolibrary.org/obo/HP_0032864	Focal aware sensory seizure with auditory features	http://purl.obolibrary.org/obo/HP_0032754	Focal aware sensory seizure		A type of focal sensory seizure with auditory features during which awareness is retained throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032865	Myoclonic absence status epilepticus	http://purl.obolibrary.org/obo/HP_0032860	Generalized non-convulsive status epilepticus without coma		Myoclonic absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged myoclonic absence seizure. Myoclonic absence status epilepticus consists of proximal, predominantly upper extremity myoclonic jerks corresponding with 3 Hz spike-wave discharges in the EEG.
http://purl.obolibrary.org/obo/HP_0032866	Oculoclonic status epilepticus	http://purl.obolibrary.org/obo/HP_0032663	Focal motor status epilepticus		A type of focal motor status epilepticus characterized by repetitive and rapid saccades, in association with epileptic discharges.
http://purl.obolibrary.org/obo/HP_0032867	Refractory status epilepticus	http://purl.obolibrary.org/obo/HP_0002133	Status epilepticus		Refractory status epilepticus is defined as status epilepticus continuing despite two appropriately selected and dosed antiepileptic drugs, including a benzodiazepine.
http://purl.obolibrary.org/obo/HP_0032868	Super-refractory status epilepticus	http://purl.obolibrary.org/obo/HP_0032867	Refractory status epilepticus		Super-refractory status epilepticus is defined as refractory status epilepticus continuing for 24 h or more following initiation of anesthetic medications, including cases in which seizure control is attained after induction of anesthetic drugs but recurs on weaning the patient off the anesthetic agent.
http://purl.obolibrary.org/obo/HP_0032869	Focal non-convulsive status epilepticus without impairment of consciousness	http://purl.obolibrary.org/obo/HP_0032673	Focal non-convulsive status epilepticus without coma		Focal non-convulsive status epilepticus without impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness remains intact.
http://purl.obolibrary.org/obo/HP_0032870	Focal impaired awareness cognitive seizure with dyslexia/alexia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with dyslexia / alexia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032871	Focal aware cognitive seizure with hallucination	http://purl.obolibrary.org/obo/HP_0032681	Focal aware cognitive seizure		A focal cognitive seizure with hallucination characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032872	Focal impaired awareness cognitive seizure with illusion	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with illusion characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032873	Focal aware sensory seizure with cephalic sensation	http://purl.obolibrary.org/obo/HP_0032810	Focal sensory seizure with cephalic sensation		A seizure characterized by a sensation in the head such as light-headedness or headache.
http://purl.obolibrary.org/obo/HP_0032874	Focal impaired awareness cognitive seizure with auditory agnosia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with auditory agnosia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032876	Focal aware cognitive seizure with conduction dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032698	Focal cognitive seizure with conduction dysphasia/aphasia		A focal cognitive seizure with conduction dysphasia / aphasia characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032877	Focal aware sensory seizure with hot-cold sensations	http://purl.obolibrary.org/obo/HP_0032760	Focal sensory seizure with hot-cold sensations		A seizure characterized by sensations of feeling hot and then cold.
http://purl.obolibrary.org/obo/HP_0032878	Focal impaired awareness sensory seizure with cephalic sensation	http://purl.obolibrary.org/obo/HP_0032810	Focal sensory seizure with cephalic sensation		A focal sensory seizure with cephalic sensation in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032879	Focal impaired awareness seizure with dissociation at onset	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive epileptic seizure with dissociation at the onset of the seizure and with impairment of awareness at at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032880	Focal impaired awareness sensory seizure with auditory features	http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure		A focal sensory seizure with auditory features in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032882	Focal impaired awareness cognitive seizure with deja vu/jamais vu	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with deja vu / jamais vu characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032883	Focal aware cognitive seizure with deja vu/jamais vu	http://purl.obolibrary.org/obo/HP_0032681	Focal aware cognitive seizure		A focal cognitive seizure with deja vu / jamais vu characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032884	Focal aware sensory seizure with somatosensory features	http://purl.obolibrary.org/obo/HP_0032754	Focal aware sensory seizure		A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move. Awareness is retained throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032885	Focal impaired awareness cognitive seizure with hallucination	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with hallucination characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032886	Focal impaired awareness cognitive seizure with expressive dysphasia/aphasia	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with expressive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032887	Generalized atonic seizure	http://purl.obolibrary.org/obo/HP_0032677	Generalized-onset motor seizure		Generalized atonic seizure is a type of generalized motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1-2 s, involving head, trunk, jaw, or limb musculature.
http://purl.obolibrary.org/obo/HP_0032888	Focal impaired awareness cognitive seizure with forced thinking	http://purl.obolibrary.org/obo/HP_0032756	Focal impaired awareness cognitive seizure		A focal cognitive seizure with forced thinking characterized by impairment of awareness at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032889	Focal aware sensory seizure with gustatory features	http://purl.obolibrary.org/obo/HP_0032754	Focal aware sensory seizure		A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes.
http://purl.obolibrary.org/obo/HP_0032890	Focal impaired awareness sensory seizure with somatosensory features	http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure		A focal sensory seizure with somatosensory features in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032891	Focal aware motor seizure with version	http://purl.obolibrary.org/obo/HP_0020217	Focal aware motor seizure		A focal motor seizure with version characterized by retained awareness throughout the seizure.
http://purl.obolibrary.org/obo/HP_0032892	Infection-related seizure	http://purl.obolibrary.org/obo/HP_0001250	Seizure		Seizure associated with a presumed or proven infection (excluding infection of the central nervous system) or inflammatory state without an alternative precipitant such as metabolic derangement, and regardless of the presence or absence of a fever.
http://purl.obolibrary.org/obo/HP_0032893	Gastroenteritis-related afebrile seizure	http://purl.obolibrary.org/obo/HP_0032892	Infection-related seizure		Afebrile (less than 38.0 degrees Celcius), brief, and generalized seizures accompanying gastroenteritis without an alternative cause.
http://purl.obolibrary.org/obo/HP_0032895	Febrile seizure outside the age of 3 months to 6 years	http://purl.obolibrary.org/obo/HP_0032894	Seizure precipitated by febrile infection		Any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38.0 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in people beyond the typical arrange of 3 months-6 years with no prior history of afebrile seizure.
http://purl.obolibrary.org/obo/HP_0032896	Music-induced seizure	http://purl.obolibrary.org/obo/HP_0020207	Reflex seizure		Seizure precipitated by listening to music or other complex sounds.
http://purl.obolibrary.org/obo/HP_0032897	Focal impaired awareness sensory seizure with gustatory features	http://purl.obolibrary.org/obo/HP_0032787	Focal impaired awareness sensory seizure		A focal sensory seizure with gustatory features in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure	http://purl.obolibrary.org/obo/HP_0011153	Focal motor seizure		A focal seizure characterized at onset by coordinated motor activity. This often resembles a voluntary movement and may consist of an inappropriate continuation of preictal motor activity.
http://purl.obolibrary.org/obo/HP_0032899	Focal orofacial automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by orofacial automatisms at onset.
http://purl.obolibrary.org/obo/HP_0032900	Focal manual automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by manual automatisms at onset.
http://purl.obolibrary.org/obo/HP_0032901	Focal pedal automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.
http://purl.obolibrary.org/obo/HP_0032902	Focal perseverative automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset.
http://purl.obolibrary.org/obo/HP_0032903	Focal vocal automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset.
http://purl.obolibrary.org/obo/HP_0032904	Focal verbal automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset.
http://purl.obolibrary.org/obo/HP_0032905	Focal sexual automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by involuntary sexual behavior at onset.
http://purl.obolibrary.org/obo/HP_0032906	Focal head nodding automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by involuntary head nodding at onset.
http://purl.obolibrary.org/obo/HP_0032907	Focal undressing automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure characterized by involuntary undressing at onset.
http://purl.obolibrary.org/obo/HP_0032908	Focal aware undressing automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by involuntary undressing at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A focal seizure with automatism in which awareness is partially or fully impaired at some point during the seizure.
http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure	http://purl.obolibrary.org/obo/HP_0032898	Focal automatism seizure		A type of focal automatism seizure during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032911	Focal aware orofacial automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by orofacial automatisms at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032912	Focal aware manual automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by manual automatisms at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032913	Focal aware pedal automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset and during which awareness is fully retained throughout. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.
http://purl.obolibrary.org/obo/HP_0032914	Focal aware perseverative automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032915	Focal aware vocal automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032916	Focal aware verbal automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032917	Focal aware sexual automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by involuntary sexual behavior at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032918	Focal impaired awareness orofacial automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by orofacial automatisms at onset.
http://purl.obolibrary.org/obo/HP_0032919	Focal aware head nodding automatism seizure	http://purl.obolibrary.org/obo/HP_0032910	Focal aware automatism seizure		A type of focal automatism seizure characterized by involuntary head nodding at onset and during which awareness is fully retained throughout.
http://purl.obolibrary.org/obo/HP_0032920	Focal impaired awareness manual automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by manual automatisms at onset.
http://purl.obolibrary.org/obo/HP_0032921	Focal impaired awareness pedal automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.
http://purl.obolibrary.org/obo/HP_0032922	Focal impaired awareness perseverative automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by inappropriate continuation of pre-seizure movement or behavior at onset.
http://purl.obolibrary.org/obo/HP_0032923	Focal impaired awareness vocal automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset.
http://purl.obolibrary.org/obo/HP_0032924	Focal impaired awareness verbal automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive words, phrases, or brief sentences at onset.
http://purl.obolibrary.org/obo/HP_0032925	Focal impaired awareness sexual automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by involuntary sexual behavior at onset.
http://purl.obolibrary.org/obo/HP_0032926	Focal impaired awareness head nodding automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary head nodding at onset.
http://purl.obolibrary.org/obo/HP_0032927	Focal impaired awareness undressing automatism seizure	http://purl.obolibrary.org/obo/HP_0032909	Focal impaired awareness automatism seizure		A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary undressing at onset.
http://purl.obolibrary.org/obo/HP_0032928	Elevated CSF neurofilament light chain concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large caliber myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases.
http://purl.obolibrary.org/obo/HP_0032929	Abnormal chondrocyte morphology	http://purl.obolibrary.org/obo/HP_0002763	Abnormal cartilage morphology		Any abnormal structure of a chondrocyte, which is a polymorphic cell that forms cartilage.
http://purl.obolibrary.org/obo/HP_0032930	Lacunar halos around chondrocytes	http://purl.obolibrary.org/obo/HP_0032929	Abnormal chondrocyte morphology		Concentric rings around the chondrocytes.
http://purl.obolibrary.org/obo/HP_0032932	Increased circulating pancreatic triacylglycerol lipase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An increased level of triacylglycerol lipase in the blood circulation (can be measured in serum or plasma).
http://purl.obolibrary.org/obo/HP_0032933	Airway hyperresponsiveness	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		An increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist.
http://purl.obolibrary.org/obo/HP_0032934	Spontaneous cerebrospinal fluid leak	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		A spontaneous cerebrospinal fluid leak (SCSFL) is a spontaneous and unexplained leak of the cerebrospinal fluid from the dura surrounding either the brain (cranial leak) or spine (spinal leak).
http://purl.obolibrary.org/obo/HP_0032935	Posterior crocodile shagreen of the cornea	http://purl.obolibrary.org/obo/HP_0007881	Central corneal dystrophy		Grayish, polygonal pattern of opacities with intervening clear zones across the central cornea that resembles crocodile skin.
http://purl.obolibrary.org/obo/HP_0032936	Intrusion symptom	http://purl.obolibrary.org/obo/HP_5200230	Maladaptive fear-related cognitions		Unintentional re-experiencing of a traumatic event involves symptoms that typically include sensory impressions and emotional responses stemming from the trauma. These symptoms seem to lack a sense of time perspective and context.
http://purl.obolibrary.org/obo/HP_0032937	Intrusive mental imagery	http://purl.obolibrary.org/obo/HP_0032936	Intrusion symptom		After experiencing psychological trauma, individuals may repeatedly encounter sensory-perceptual impressions of the event that intrude into their consciousness involuntarily. These intrusive memories often manifest as visual images (such as mental pictures), but can also involve sounds, smells, tastes, and physical sensations. They are accompanied by a variety of negative emotions linked to the most intense moments of the traumatic memory.
http://purl.obolibrary.org/obo/HP_0032938	Recurrent trauma-related distressing dreams	http://purl.obolibrary.org/obo/HP_0032936	Intrusion symptom		Recurrent distressing dreams occur when the content and/or emotional impact of the dream is connected to a traumatic event or events.
http://purl.obolibrary.org/obo/HP_0032939	Physiological reactivity to cues	http://purl.obolibrary.org/obo/HP_0032936	Intrusion symptom		Marked physiological reactions to internal or external cues that symbolize or resemble an aspect of the traumatic event(s).
http://purl.obolibrary.org/obo/HP_0032940	Dissociation	http://purl.obolibrary.org/obo/HP_5200216	Abnormal perceptual state		Disruption or detachment of certain aspects of one's normal psychological functioning typically involves a disconnection or separation from thoughts, feelings, sensations, memories, or one's sense of identity or reality.
http://purl.obolibrary.org/obo/HP_0032941	Intense psychological distress to cues	http://purl.obolibrary.org/obo/HP_0032936	Intrusion symptom		Intense or prolonged psychological distress occurs when individuals are exposed to internal or external cues that symbolize or resemble an aspect of the traumatic event or events.
http://purl.obolibrary.org/obo/HP_0032942	Avoidance of stimuli associated with traumatic event	http://purl.obolibrary.org/obo/HP_0100852	Abnormal fear-induced behavior		Avoidance of or efforts to avoid distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s). Avoidance of or efforts to avoid external reminders (people, places, conversations, activities, objects, situations) that arouse distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s).
http://purl.obolibrary.org/obo/HP_0032944	Alkaline urine	http://purl.obolibrary.org/obo/HP_0032943	Abnormal urine pH		Urine pH of 8 or higher.
http://purl.obolibrary.org/obo/HP_0041051	Ageusia	http://purl.obolibrary.org/obo/HP_0000223	Abnormality of taste sensation		A rare condition that is characterized by a complete loss of taste function of the tongue.
http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology	http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine		Any morphological abnormality of the cervical vertebral column.
http://purl.obolibrary.org/obo/CHEBI_157668	carbocyclic fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_28868	fatty acid anion		Any fatty acid anion containing a ring composed of carbon atoms. Major microspecies at pH 7.3
http://purl.obolibrary.org/obo/GO_0140513	nuclear protein-containing complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.
http://purl.obolibrary.org/obo/GO_0140546	defense response to symbiont	http://purl.obolibrary.org/obo/GO_0098542	defense response to other organism		Reactions triggered in response to the presence of a symbiont that act to protect or prevent damage to the host.
http://purl.obolibrary.org/obo/CL_0009021	stromal cell of lamina propria of large intestine	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A stromal cell found in the lamina propria of the large intestine.
http://purl.obolibrary.org/obo/CL_0009022	stromal cell of lamina propria of small intestine	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A stromal cell found in the lamina propria of the small intestine.
http://purl.obolibrary.org/obo/CL_0009024	mesothelial cell of small intestine	http://purl.obolibrary.org/obo/CL_0008041	mesothelial cell of intestine		A mesothelial cell that is part of the small intestine.
http://purl.obolibrary.org/obo/CL_0009025	mesothelial cell of colon	http://purl.obolibrary.org/obo/CL_0008041	mesothelial cell of intestine		A mesothelial cell that is part of the colon.
http://purl.obolibrary.org/obo/CHEBI_189840	dicarboxylic fatty acid	http://purl.obolibrary.org/obo/CHEBI_35692	dicarboxylic acid		Any fatty acid containing two carboxy groups.
http://purl.obolibrary.org/obo/CL_0009100	hepatic portal fibroblast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen.
http://purl.obolibrary.org/obo/UBERON_8410081	blood microvessel	http://purl.obolibrary.org/obo/UBERON_0010523	microcirculatory vessel		Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins.
http://purl.obolibrary.org/obo/CL_4023168	somatosensory neuron	http://purl.obolibrary.org/obo/CL_2000032	peripheral nervous system neuron		A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli.
http://purl.obolibrary.org/obo/CL_4023079	midbrain-derived inhibitory neuron	http://purl.obolibrary.org/obo/CL_2000029	central nervous system neuron		A GABAergic inhibitory neuron that is derived from the midbrain.
http://purl.obolibrary.org/obo/HP_0034434	Abnormal communication	http://purl.obolibrary.org/obo/HP_0025792	Abnormal cognitive process		Presence of any form of communication (e.g., verbal or non-verbal) that does not align with cultural expectations or developmental level.
http://purl.obolibrary.org/obo/HP_0034435	Abnormal eye contact	http://purl.obolibrary.org/obo/HP_0000758	Abnormal nonverbal communicative behavior		Any abnormality of eye contact behavior. We define eye contact as a form of nonverbal communication between two individuals who are facing each other in which an individual directs the eyes towards the eyes or face of the other individual. Eye contact occurs frequently and voluntarily during face-to-face verbal communication. The duration and frequency of eye contact that is interpreted to be appropriate may follow social and situational norms.
http://purl.obolibrary.org/obo/CL_4033061	endothelial cell of central vein of liver	http://purl.obolibrary.org/obo/CL_0002543	vein endothelial cell		An endothelial cell that is part of a central vein of liver.
http://purl.obolibrary.org/obo/HP_5201015	Craniofacial cleft	http://purl.obolibrary.org/obo/HP_0000234	Abnormality of the head		Congenital abnormality with cleft (gap or opening) in the craniofacial bones. Craniofacial cleft includes facial cleft, orofacial clef, and cleft of the jaw.
http://purl.obolibrary.org/obo/GO_0170033	L-amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0006520	amino acid metabolic process		The chemical reactions and pathways involving an L-amino acid.
http://purl.obolibrary.org/obo/HP_0025799	Abnormal wrist physiology	http://purl.obolibrary.org/obo/HP_0003019	Abnormality of the wrist		Any functional anomaly of the wrist.
http://purl.obolibrary.org/obo/UBERON_7770007	descending colon epithelium	http://purl.obolibrary.org/obo/UBERON_0000397	colonic epithelium		An epithelial layer that lines the descending colon.
http://purl.obolibrary.org/obo/UBERON_7770008	sigmoid colon epithelium	http://purl.obolibrary.org/obo/UBERON_0000397	colonic epithelium		An epithelial layer that lines the sigmoid colon.
http://purl.obolibrary.org/obo/UBERON_8600135	descending colon lamina propria	http://purl.obolibrary.org/obo/UBERON_0011189	lamina propria of large intestine		The lamina propria that underlies the epithelial lining of the descending colon.
http://purl.obolibrary.org/obo/UBERON_8600136	sigmoid colon lamina propria	http://purl.obolibrary.org/obo/UBERON_0011189	lamina propria of large intestine		The lamina propria that underlies the epithelial lining of the sigmoid colon.
http://purl.obolibrary.org/obo/UBERON_8600140	rectum lamina propria	http://purl.obolibrary.org/obo/UBERON_0011189	lamina propria of large intestine		The lamina propria that underlies the epithelial lining of the rectum.
http://purl.obolibrary.org/obo/CL_0008061	GABA-Chol neuron	http://purl.obolibrary.org/obo/CL_0000617	GABAergic neuron		A neuron that releases both gamma-aminobutyric acid and acetylcholine as vesicular neurotransmitters.  Examples include some types of striatal interneuron.
http://purl.obolibrary.org/obo/GO_0120032	regulation of plasma membrane bounded cell projection assembly	http://purl.obolibrary.org/obo/GO_0120035	regulation of plasma membrane bounded cell projection organization		Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly.
http://purl.obolibrary.org/obo/GO_0120033	negative regulation of plasma membrane bounded cell projection assembly	http://purl.obolibrary.org/obo/GO_0120032	regulation of plasma membrane bounded cell projection assembly		Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly.
http://purl.obolibrary.org/obo/GO_0120034	positive regulation of plasma membrane bounded cell projection assembly	http://purl.obolibrary.org/obo/GO_0120032	regulation of plasma membrane bounded cell projection assembly		Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly.
http://purl.obolibrary.org/obo/CHEBI_137682	methylhistidine	http://purl.obolibrary.org/obo/CHEBI_24599	histidine derivative		A histidine derivative in which histidine is substituted with a methyl group.
http://purl.obolibrary.org/obo/CHEBI_137982	tertiary ammonium ion	http://purl.obolibrary.org/obo/CHEBI_25697	organic cation		An organic cation obtained by protonation of the amino group of any tertiary amino compound.
http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity	http://purl.obolibrary.org/obo/CHEBI_33579	main group molecular entity		Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0°C and 100 kPa).
http://purl.obolibrary.org/obo/HP_0031772	Abnormal posterior circulating artery morphology	http://purl.obolibrary.org/obo/HP_0012518	Abnormal circle of Willis morphology		Any structural anomaly of the posterior circulating artery (PCOM).
http://purl.obolibrary.org/obo/HP_0031773	Posterior communicating artery aneurysm	http://purl.obolibrary.org/obo/HP_0031772	Abnormal posterior circulating artery morphology		A widening (ballooning) localized in the wall of the posterior communicating artery.
http://purl.obolibrary.org/obo/HP_0031774	Posterior communicating artery infundibulum	http://purl.obolibrary.org/obo/HP_0031772	Abnormal posterior circulating artery morphology		A funnel-shaped symmetrical enlargement of the origin of the posterior communicating artery at its junction with the internal carotid artery.
http://purl.obolibrary.org/obo/HP_0031775	Neurogenic strabismus	http://purl.obolibrary.org/obo/HP_0000486	Strabismus		An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them.
http://purl.obolibrary.org/obo/HP_0031776	Cyclotropia	http://purl.obolibrary.org/obo/HP_0025589	Cyclodeviation		A form of manifest strabismus (heterotropia) in which the one eye is wheel rotated so that the upper end of its vertical axis is nasal (incyclotropia) or temporal (excyclotropia).
http://purl.obolibrary.org/obo/HP_0031777	Cyclophoria	http://purl.obolibrary.org/obo/HP_0025589	Cyclodeviation		A form of latent strabismus (heterophoria) in which the occluded eye wheel-rotates on dissociation.
http://purl.obolibrary.org/obo/HP_0031778	Incyclophoria	http://purl.obolibrary.org/obo/HP_0031777	Cyclophoria		A type of cyclophoria (latent strabismus in which the occluded eye wheel-rotates on dissociation.) in which the upper poles of the globes are rotated inward (medially) to each other.
http://purl.obolibrary.org/obo/HP_0031779	Excyclophoria	http://purl.obolibrary.org/obo/HP_0031777	Cyclophoria		A type of cyclophoria (latent strabismus in which the occluded eye wheel-rotates on dissociation.) in which the upper poles of the globes are rotated outward (laterally) to each other.
http://purl.obolibrary.org/obo/HP_0031780	Eosinophilic ascites	http://purl.obolibrary.org/obo/HP_0032064	Gastrointestinal eosinophilia		A type of ascites in which there are large numbers of eosinophils in the ascitis fluid.
http://purl.obolibrary.org/obo/HP_0031781	Microtropia with identity	http://purl.obolibrary.org/obo/HP_0031724	Microtropia		A type of microtropia with no manifest movement on cover test, the eccentric fixation point coinciding with the angle of ARC.
http://purl.obolibrary.org/obo/HP_0031782	Microtropia without identity	http://purl.obolibrary.org/obo/HP_0031724	Microtropia		A type of microtropia in which the manifest movement is demonstrated on the cover-uncover test.
http://purl.obolibrary.org/obo/HP_0031783	Absent coronary sinus	http://purl.obolibrary.org/obo/HP_0011642	Abnormal coronary sinus morphology		A developmental defect in which the coronary sinus fails to form.
http://purl.obolibrary.org/obo/HP_0031785	Abnormal eyelid movement	http://purl.obolibrary.org/obo/HP_0031879	Abnormal eyelid physiology		An abnormality in voluntary or involuntary eyelid movements or their control.
http://purl.obolibrary.org/obo/HP_0031786	Cogan lid twitch	http://purl.obolibrary.org/obo/HP_0031785	Abnormal eyelid movement		Transient eyelid retraction during refixation from down to straight ahead.
http://purl.obolibrary.org/obo/HP_0031787	Oblique astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		Astigmatism in which the refractive power of the vertical meridian is the greatest.
http://purl.obolibrary.org/obo/HP_0031788	With the rule astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		Refractive error in which the vertical meridian is relatively hypermetropic and the horizontal meridian is relatively myopic (or ocular astigmatism in which the refractive power of the horizontal meridian is the greatest).
http://purl.obolibrary.org/obo/HP_0031789	Against the rule astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		Astigmatism with more plus power on the horizontal meridian.
http://purl.obolibrary.org/obo/HP_0031790	Mixed astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		A type of astigmatism in which an unequal curvature of the cornea and some cases additionally of the lens causes one meridian of the eye to be hyperopic (farsighted) and a second meridian that is perpendicular to the first to be myopic (nearsighted).
http://purl.obolibrary.org/obo/HP_0031791	Lenticular astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		A type of astigmatism related to an irregular shape of the lens.
http://purl.obolibrary.org/obo/HP_0031792	Irregular astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		A type of astigmatism in which the principle meridians are not 90 degrees apart and which is associated with loss of vision.
http://purl.obolibrary.org/obo/HP_0031793	Increased serum leptin	http://purl.obolibrary.org/obo/HP_0004361	Abnormal circulating leptin concentration		An increased concentration of leptin in the blood.
http://purl.obolibrary.org/obo/HP_0031794	Decreased circulating glycerol level	http://purl.obolibrary.org/obo/HP_0031795	Abnormal circulating glycerol level		A decrease below the normal concentration of glycerol in the blood.
http://purl.obolibrary.org/obo/HP_0031795	Abnormal circulating glycerol level	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		Any deviation from the normal concentration of glycerol in the blood.
http://purl.obolibrary.org/obo/HP_0031796	Recurrent	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		Applies to a sign, symptom or manifestation that occurs multiple times separated by intervals in which the sign, symptom, or manifestation is not present.
http://purl.obolibrary.org/obo/HP_0031798	Elevated circulating apolipoprotein B concentration	http://purl.obolibrary.org/obo/HP_0033460	Elevated circulating apolipoprotein concentration		The concentration of apolipoprotein B in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031799	Decreased circulating apolipoprotein A-I concentration	http://purl.obolibrary.org/obo/HP_0033459	Decreased circulating apolipoprotein concentration		The concentration of apolipoprotein A-I in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0031800	Elevated circulating apolipoprotein A-II concentration	http://purl.obolibrary.org/obo/HP_0033460	Elevated circulating apolipoprotein concentration		The concentration of apolipoprotein A-II in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0031805	Intraretinal hemorrhage	http://purl.obolibrary.org/obo/HP_0000573	Retinal hemorrhage		A subtype of fundus hemorrhage occurring within the neurosensory retina. Intraretinal hemorrhages may be 'dot' or' blot' shaped, flame shaped or confluent depending upon their depth within the retina.
http://purl.obolibrary.org/obo/HP_0410050	Decreased circulating 1,5 anhydroglucitol concentration	http://purl.obolibrary.org/obo/HP_0020347	Abnormal circulating monosaccharide concentration		Concetration of 1,5 anhydroglucitol in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0410051	Increased level of 3-hydroxy-3-methylglutaric acid in urine	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of 3-hydroxy-3-methylglutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410052	Increased level of allantoin in serum	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		An increase in the level of allantoin in the serum.
http://purl.obolibrary.org/obo/HP_0410053	Elevated circulating gamma-aminobutyric acid concentration	http://purl.obolibrary.org/obo/HP_0034025	Abnormal circulating GABA concentration		An increase in the level of Gamma-aminobutyric acid (GABA) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0410054	Decreased circulating GABA concentration	http://purl.obolibrary.org/obo/HP_0034025	Abnormal circulating GABA concentration		A decrease in the level of GABA in the serum.
http://purl.obolibrary.org/obo/HP_0410055	Decreased level of erythritol in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		A decrease in the level of erythritol in the urine.
http://purl.obolibrary.org/obo/HP_0410056	Decreased CSF erythritol concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Concentration of erythritol in the cerebrospinal fluid below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0410057	Elevated circulating D-threitol concentration	http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration		The concentration of D-threitol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410058	Increased CSF D-threitol concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of D-threitol in the cerebrospinal fluid is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410059	Increased level of D-threitol in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increase in the level of D-threitol in the urine.
http://purl.obolibrary.org/obo/HP_0410060	Decreased level of D-mannose in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		A decrease in the level of D-mannose in the urine.
http://purl.obolibrary.org/obo/HP_0410061	Increased circulating galactitol concentration	http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration		The concentration of galactitol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410062	Increased level of galactitol in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increase in the level of galactitol in the urine.
http://purl.obolibrary.org/obo/HP_0410063	Increased level of galactonate in red blood cells	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		An increase in the level of galactonate in the red blood cells.
http://purl.obolibrary.org/obo/HP_0410064	Increased level of galactitol in red blood cells	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		An increase in the level of galactitol in the red blood cells.
http://purl.obolibrary.org/obo/HP_0410065	Increased level of hippuric acid in blood	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		An increase in the level of hippuric acid in the blood.
http://purl.obolibrary.org/obo/HP_0410066	Increased level of hippuric acid in urine	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		An increase in the level of hippuric acid in the urine.
http://purl.obolibrary.org/obo/HP_0410067	Increased level of L-fucose in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increase in the level of L-fucose in the urine.
http://purl.obolibrary.org/obo/HP_0410069	Increased level of propylene glycol in blood	http://purl.obolibrary.org/obo/HP_0032180	Abnormal circulating metabolite concentration		An increase in the level of propylene glycol in the blood.
http://purl.obolibrary.org/obo/HP_0410070	Increased level of ribitol in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increase in the level of ribitol in the urine. Ribotol is a crystalline pentose alcohol (C5H12O5) and is a metabolic end product formed by the reduction of ribose.
http://purl.obolibrary.org/obo/HP_0410071	Increased CSF ribitol concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of ribitol in the cerebrospinal fluid is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410072	Increased level of ribose in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increase in the level of ribose in the urine.
http://purl.obolibrary.org/obo/HP_0410073	Increased CSF ribose concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of ribose in the cerebrospinal fluid is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410074	Increased level of xylitol in urine	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		An increase in the level of xylitol in the urine.
http://purl.obolibrary.org/obo/HP_0410075	Increased CSF xylitol concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		The concentration of xylitol in the cerebrospinal fluid is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0410132	Increased level of L-pyroglutamic acid in urine	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		An increase in the level of L-pyroglutamic acid in the urine.
http://purl.obolibrary.org/obo/HP_0410133	Chronic urticaria	http://purl.obolibrary.org/obo/HP_0001025	Urticaria		Urticaria characterized by spontaneously recurring hives for 6 weeks or longer.
http://purl.obolibrary.org/obo/HP_0410134	Physical urticaria	http://purl.obolibrary.org/obo/HP_0001025	Urticaria		Urticaria caused by physical agents, such as heat, cold, light, friction.
http://purl.obolibrary.org/obo/HP_0410135	Cold urticaria	http://purl.obolibrary.org/obo/HP_0410134	Physical urticaria		Urticaria may be caused by cold temperatures.
http://purl.obolibrary.org/obo/HP_0410136	Aquagenic urticaria	http://purl.obolibrary.org/obo/HP_0410134	Physical urticaria		A form of physical urticaria, in which contact with water, regardless of its temperature and source, evokes pruritic follicular wheals on the skin.
http://purl.obolibrary.org/obo/HP_0410137	Solar urticaria	http://purl.obolibrary.org/obo/HP_0410134	Physical urticaria		Urticaria in response to exposure to ultraviolet-A (UVA), ultraviolet-B (UVB), visible and rarely infrared light.
http://purl.obolibrary.org/obo/HP_0410138	Vibratory urticaria	http://purl.obolibrary.org/obo/HP_0410134	Physical urticaria		Urticaria in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum.
http://purl.obolibrary.org/obo/HP_0410139	Exercise induced anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845	Anaphylactic shock		Anaphylaxis after physical activity.
http://purl.obolibrary.org/obo/HP_0500034	Nasolacrimal sac obstruction	http://purl.obolibrary.org/obo/HP_3000066	Abnormal lacrimal sac morphology		Blockage of the nasolacrimal sac.
http://purl.obolibrary.org/obo/HP_0500035	Nasolacrimal sac granuloma	http://purl.obolibrary.org/obo/HP_0500034	Nasolacrimal sac obstruction		A mass of granulation tissue in response to chronic dacryocystitis as polypoid formations or they follow accidental injury, from probing and as a reaction to retained foreign bodies in the sac.
http://purl.obolibrary.org/obo/HP_0500036	Nasolacrimal sac papilloma	http://purl.obolibrary.org/obo/HP_0500035	Nasolacrimal sac granuloma		Benign tumor of the nasolacrimal sac.
http://purl.obolibrary.org/obo/HP_0500037	Nasolacrimal sac epithelial papillary carcinoma	http://purl.obolibrary.org/obo/HP_3000066	Abnormal lacrimal sac morphology		The malignant epithelial neoplasm with papillary growths in the nasolacrimal sac.
http://purl.obolibrary.org/obo/HP_0500039	Conjunctival cicatrization	http://purl.obolibrary.org/obo/HP_0030947	Conjunctival follicles		An abnormality of the conjuctiva and ocular surface caused by conjunctival inflammation and associated with scarring.
http://purl.obolibrary.org/obo/HP_0500040	Dermolipoma of the conjunctiva	http://purl.obolibrary.org/obo/HP_0500039	Conjunctival cicatrization		A benign tumor composed of adipose tissue and dense connective tissue usually located near the temporal fornix.
http://purl.obolibrary.org/obo/HP_0500041	Myopic astigmatism	http://purl.obolibrary.org/obo/HP_0000483	Astigmatism		A condition where one or both of the two principal meridians focus in the front of the retina when the eye is at rest.
http://purl.obolibrary.org/obo/HP_0500042	Latent hypermetropia	http://purl.obolibrary.org/obo/HP_0008499	High hypermetropia		A term to describe when farsightedness is masked when the accommodative muscles are used to increase the focusing power of the eye.
http://purl.obolibrary.org/obo/HP_0500043	Eyelid retraction	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		With the eyes in primary position, the sclera is visible above the superior corneal limbus.
http://purl.obolibrary.org/obo/HP_0500044	Upper eyelid retraction	http://purl.obolibrary.org/obo/HP_0500043	Eyelid retraction		An elevation of the eyelid above the normal level in the primary position.
http://purl.obolibrary.org/obo/HP_0500045	Collier's sign	http://purl.obolibrary.org/obo/HP_0500044	Upper eyelid retraction		A unilateral or bilateral eyelid retraction due to midbrain lesions.
http://purl.obolibrary.org/obo/HP_0500046	Seborrhoeic blepharitis	http://purl.obolibrary.org/obo/HP_0025610	Posterior blepharitis		Inflammation of the eyelid due to overactivity of the sebaceous gland.
http://purl.obolibrary.org/obo/HP_0500047	Nasolacrimal sac lymphoma	http://purl.obolibrary.org/obo/HP_3000066	Abnormal lacrimal sac morphology		A type of lymphoma that involves the nasolacrimal sac.
http://purl.obolibrary.org/obo/HP_0500048	Delayed canalization of nasolacrimal duct	http://purl.obolibrary.org/obo/HP_0000579	Nasolacrimal duct obstruction		A very common condition in which the extreme end of the nasolacrimal duct underneath the inferior turbinate fails to complete its canalization in the newborn period.
http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity	http://purl.obolibrary.org/obo/HP_0000488	Retinopathy		An avascular or abnormally vascularized retina that occurs in premature infants and can lead to blindness.
http://purl.obolibrary.org/obo/HP_0500050	Retinopathy of prematurity stage 1	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		The retinal vessels stop and then a linear flat white line is present that usually runs the circumference of the vascular retina.
http://purl.obolibrary.org/obo/HP_0500051	Retinopathy of prematurity stage 2	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		The accumulating neovascularization thickens and manifests as a linear bump. The neovascularization remains along the surface of the retina and does not extend off the retina into the cortical vitreous.
http://purl.obolibrary.org/obo/HP_0500052	Retinopathy of prematurity stage 3	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		The neovascularization accumulates at the edge of the vascularized retina and extends into the vitreous (also called extra retinal fibrosis proliferation). In cases of Zone 2 and Zone 3, this may be sausage shaped. In more posterior Zone 1 disease, the stage 3 can appear as a direct extension of the normal retinal vessels but extending tangentially over the avascular retina.
http://purl.obolibrary.org/obo/HP_0500053	Retinopathy of prematurity stage 4	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		Scar tissue that forms a continuous sheet coming up from the edge of the vascularized retina. This scar tissue can grow toward the vitreous base/posterior lens capsule resulting in traction, distortion, and even detachment.
http://purl.obolibrary.org/obo/HP_0500054	Retinopathy of prematurity stage 4a	http://purl.obolibrary.org/obo/HP_0500053	Retinopathy of prematurity stage 4		A detachment that involves the peripheral retina that does not extend into the macula.
http://purl.obolibrary.org/obo/HP_0500055	Retinopathy of prematurity stage 4b	http://purl.obolibrary.org/obo/HP_0500053	Retinopathy of prematurity stage 4		A detachment that involves the peripheral retina that involves the macula itself. The detachment usually starts in the temporal periphery although can also involve the nasal retina as well.
http://purl.obolibrary.org/obo/HP_0500056	Retinopathy of prematurity stage 5	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		Funnel detachment from the retina with generally traction in all four quadrants.
http://purl.obolibrary.org/obo/HP_0500057	Retinopathy of prematurity stage 5a	http://purl.obolibrary.org/obo/HP_0500056	Retinopathy of prematurity stage 5		An open funnel detachment of the retina with generally traction in all four quadrants.
http://purl.obolibrary.org/obo/HP_0500058	Retinopathy of prematurity stage 5b	http://purl.obolibrary.org/obo/HP_0500056	Retinopathy of prematurity stage 5		A closed funnel detachment of the retina with generally traction in all four quadrants.
http://purl.obolibrary.org/obo/HP_0500059	Retinopathy of prematurity zone I	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		Retinopathy which extends from the center of the optic disc to twice the distance from the center of the optic disc to the center of the macula.
http://purl.obolibrary.org/obo/HP_0500060	Retinopathy of prematurity zone II	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		Retinopathy which extends centrifugally from the edge of zone I to the nasal ora serrata.
http://purl.obolibrary.org/obo/HP_0500061	Retinopathy of prematurity zone III	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		Retinopathy which is a residual crescent of retina anterior to zone II.
http://purl.obolibrary.org/obo/HP_0500062	Retinopathy of prematurity plus	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		Venous dilatation and arteriolar tortuosity of the posterior retinal vessels and may later increase in severity to include iris vascular engorgement, poor pupillary dilatation (rigid pupil), and vitreous haze. This definition has been further refined in the later clinical trials in which the diagnosis of plus disease could be made if sufficient vascular dilatation and tortuosity are present in at least 2 quadrants of the eye.
http://purl.obolibrary.org/obo/HP_0500063	Retinopathy of prematurity pre-plus	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		As vascular abnormalities of the posterior pole that are insufficient for the diagnosis of plus disease but that demonstrate more arterial tortuosity and more venous dilatation than normal.
http://purl.obolibrary.org/obo/HP_0500064	Retinopathy of prematurity threshold	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		A retinopathy with a 50% likelihood of progressing to retinal detachment. Threshold disease is considered to be present when stage 3 retinopathy of prematurity (ROP) is present in either zone I or zone II, with at least 5 continuous or 8 total clock hours of disease, and the presence of plus disease.
http://purl.obolibrary.org/obo/HP_0500065	Retinopathy of prematurity prethreshold	http://purl.obolibrary.org/obo/HP_0500049	Retinopathy of prematurity		High risk patients who were in Zone 1 (no Plus or stage 3) or Zone 2 with Plus or stage 3 but not both.
http://purl.obolibrary.org/obo/HP_0500066	Latent myopia	http://purl.obolibrary.org/obo/HP_0000545	Myopia		The difference between total and manifest myopia.
http://purl.obolibrary.org/obo/HP_0500069	Paralytic ectropion	http://purl.obolibrary.org/obo/HP_0000656	Ectropion		A type of ectropion associated with orbicularis muscle weakness caused by cranial nerve VII palsy.
http://purl.obolibrary.org/obo/HP_0500070	Conjunctival dermolipoma	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		A conjuctival lesion composed of adipose tissue and dense connective tissue. Such choristomas of dermal elements are normally found at the outer canthus, and have a gelatinous appearance. Classically, there is an indistinct posterior border (with the lesion frequently extending into the orbit) and a well-demarcated anterior border several millimeters posterior to the limbus.
http://purl.obolibrary.org/obo/HP_0500072	Absolute eccentric fixation	http://purl.obolibrary.org/obo/HP_0025549	Eccentric visual fixation		Eccentric fixation in which the angle of eccentricity equals the objective angle of deviation.
http://purl.obolibrary.org/obo/HP_0500073	Abnormal ocular alignment	http://purl.obolibrary.org/obo/HP_0000496	Abnormality of eye movement		Any deviation from the normal ocular alignment.
http://purl.obolibrary.org/obo/HP_0500074	Dissociated vertical deviation	http://purl.obolibrary.org/obo/HP_0500073	Abnormal ocular alignment		An incomitant tendency for an occluded eye to elevate and extort which resolves on uncovering.
http://purl.obolibrary.org/obo/HP_0500075	Dissociated horizontal deviation	http://purl.obolibrary.org/obo/HP_0500073	Abnormal ocular alignment		A change in horizontal ocular alignment, unrelated to accommodation, that is brought about solely by a change in the balance of visual input from the two eyes.
http://purl.obolibrary.org/obo/HP_0500076	Alternating hypertropia	http://purl.obolibrary.org/obo/HP_0025586	Hypertropia		A type of vertical tropia in which, when one eye is fixing, the other eye is deviated upwards.
http://purl.obolibrary.org/obo/HP_0500077	Alternating hyperphoria	http://purl.obolibrary.org/obo/HP_0025585	Hyperphoria		A type of vertical phoria in which, in dissociation, the occluded eye deviates upwards.
http://purl.obolibrary.org/obo/HP_0500078	Alternating hypotropia	http://purl.obolibrary.org/obo/HP_0025584	Hypotropia		A type of vertical tropia in which, when one eye is fixing, the other eye is deviated downwards.
http://purl.obolibrary.org/obo/HP_0500079	Alternating hypophoria	http://purl.obolibrary.org/obo/HP_0031725	Hypophoria		A type of vertical phoria in which, in dissociation, the occluded eye deviates downwards.
http://purl.obolibrary.org/obo/HP_0500081	Pseudophakia	http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology		The term pseudophakia refers to having an artificial lens implanted after the natural eye lens has been removed. During cataract surgery the natural cloudy lens is replaced by an pseudophakia intraocular lens (IOL).
http://purl.obolibrary.org/obo/UBERON_0036264	zygomaticotemporal nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit.
http://purl.obolibrary.org/obo/HP_0020054	Abnormal erythrocyte physiology	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of blood and blood-forming tissues		Any functional abnormality of erythrocytes (red-blood cells).
http://purl.obolibrary.org/obo/HP_0025613	Focal emotional seizure	http://purl.obolibrary.org/obo/HP_0032679	Focal non-motor seizure		Seizures presenting with an emotion or the appearance of having an emotion as an early prominent feature, such as fear, spontaneous joy or euphoria, laughing (gelastic), or crying, (dacrystic). These emotional seizures may occur with or without objective clinical signs of a seizure evident to the observer.
http://purl.obolibrary.org/obo/HP_0032072	Popliteal synovial cyst	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		A fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior to the medial femoral condyle.
http://purl.obolibrary.org/obo/HP_0032073	Aplasia of the fallopian tube	http://purl.obolibrary.org/obo/HP_0008655	Aplasia/Hypoplasia of the fallopian tube		Aplasia, that is failure to develop, of the fallopian tube.
http://purl.obolibrary.org/obo/HP_0032075	Splenopancreatic fusion	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Fusion of the pancreatic tail and spleen.
http://purl.obolibrary.org/obo/HP_0032077	Male urethral meatus stenosis	http://purl.obolibrary.org/obo/HP_0032076	Abnormal male urethral meatus morphology		An abnormal narrowing of the urethral opening (meatus) of the penis.
http://purl.obolibrary.org/obo/HP_0032078	Angel-shaped phalanx	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		A phalangeal malformation that is termed angel-shaped phalanx (ASP), because of its resemblance to the angels used for decoration of Christmas trees. The various components of an angel-shaped phalanx are: diaphyseal cuff (wings), surrounding a meta-diaphyseal core (body), which may appear empty or structured with a cone-shaped epiphysis (skirt) and pseudoepiphysis (head).
http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration	http://purl.obolibrary.org/obo/HP_0001679	Abnormal aortic morphology		Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections.
http://purl.obolibrary.org/obo/HP_0032081	Intralamellar mucoid extracellular matrix accumulation	http://purl.obolibrary.org/obo/HP_0200146	Mucoid extracellular matrix accumulation		A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix does not significantly alter the arrangement of the lamellar units.
http://purl.obolibrary.org/obo/HP_0032082	Translamellar mucoid extracellular matrix accumulation	http://purl.obolibrary.org/obo/HP_0200146	Mucoid extracellular matrix accumulation		A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix alters the arrangement of the lamellar units to varying degrees.
http://purl.obolibrary.org/obo/HP_0032083	Aortic elastic fiber fragmentation	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		Loss and/or fragmentation of elastic fibers of the media of the aorta creating increasingly extended translamellar spaces, with absence of elastic fibers, and increased gaps in elastic fiber lamellae as identified on a stain for elastic fibers.
http://purl.obolibrary.org/obo/HP_0032084	Aortic elastic fiber thinning	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		A thinning out of elastic fibers of the media of the aorta that creates widening of intralamellar spaces, as identified on a stain for elastic fibers.
http://purl.obolibrary.org/obo/HP_0032085	Aortic elastic fiber disorganization	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		Nonparallel arrangement/disarray of elastic fibers of the media of the aorta as identified on a stain for elastic fibers.
http://purl.obolibrary.org/obo/HP_0032086	Aortic smooth muscle cell nuclei loss	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		A region of the aortic media in which smooth muscle cell nuclei, involving multiple lamellae, are not clearly identifiable on an hematoxylin and eosin stain.
http://purl.obolibrary.org/obo/HP_0032087	Aortic laminar medial collapse	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		Architecturally, a compaction of aortic medial elastic fibers that creates thinning of the lamellar unit secondary to a band-like smooth muscle cell loss identified using a stain for elastic fibers.
http://purl.obolibrary.org/obo/HP_0032088	Aortic smooth muscle cell disorganization	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		Nonparallel arrangement/disarray of smooth muscle cells of the aortic media creating focal/multifocal disarray or sometimes nodular aggregates of smooth muscle cells.
http://purl.obolibrary.org/obo/HP_0032089	Aortic medial fibrosis	http://purl.obolibrary.org/obo/HP_0032079	Medial degeneration		An increase in collagen fibers creating areas of substitutive fibrosis or a widening of intralamellar spaces in the media of the aorta. This can be seen in conjunction with a loss to varying degrees of parallel arrangement of the elastic lamellae (or lamellar units).
http://purl.obolibrary.org/obo/HP_0032090	Intralamellar aortic medial fibrosis	http://purl.obolibrary.org/obo/HP_0032089	Aortic medial fibrosis		A type of aortic medial fibrosis in which the increase in collagen does not significantly alter the arrangement of the lamellar units.
http://purl.obolibrary.org/obo/HP_0032091	Translamellar aortic medial fibrosis	http://purl.obolibrary.org/obo/HP_0032089	Aortic medial fibrosis		A type of aortic medial fibrosis in which the increase in collagen is more scar-like, altering the arrangement of the lamellar units.
http://purl.obolibrary.org/obo/HP_0032092	Left ventricular outflow tract obstruction	http://purl.obolibrary.org/obo/HP_0005162	Abnormal left ventricular function		Left ventricular outflow tract (LVOT) obstruction can occur at the valvular, subvalvular, or supravalvular level. In general, there is an obstruction to forward flow which increases afterload, and if untreated, can result in hypertrophy, dilatation, and eventual failure of the left ventricle.
http://purl.obolibrary.org/obo/HP_0032094	Elevated circulating surfactant protein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of surfactant protein in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032096	Abnormal circulating manganese concentration	http://purl.obolibrary.org/obo/HP_0011030	Abnormal circulating transition element cation concentration		Any deviation from the normal concentration of manganese cation in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032097	Hypermanganesemia	http://purl.obolibrary.org/obo/HP_0032096	Abnormal circulating manganese concentration		The concentration of manganese cation in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032098	Hypomanganesemia	http://purl.obolibrary.org/obo/HP_0032096	Abnormal circulating manganese concentration		The concentration of manganese cation in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0032099	Perioral radial furrowing	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		The presence of radial grooves in the skin surrounding the mouth (see Figure 4 of PMID:27833976).
http://purl.obolibrary.org/obo/HP_0032100	Abnormal doll's eye reflex	http://purl.obolibrary.org/obo/HP_0007670	Abnormal vestibulo-ocular reflex		The doll's eye reflex (also known as oculocephalic reflex) is a test of brain function that is performed in comatose patients by elevating the head roughly 30 degrees and rapidly rotating the head from side to side with the eyes kept open. A normal response is for the eyes to move in the opposite direction. If the eyes do not move in the opposite direction this may indicate severe brain damage.
http://purl.obolibrary.org/obo/HP_0032102	Wilson sign	http://purl.obolibrary.org/obo/HP_0030839	Knee pain		Wilson sign is defined as the elicitation of pain by internally rotating the patient's tibia during knee extension between 90 degrees and 30 degrees of flexion and then relieving that pain by externally rotating the tibia.
http://purl.obolibrary.org/obo/HP_0032104	Saccadic oscillation	http://purl.obolibrary.org/obo/HP_0000570	Abnormal saccadic eye movements		An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by an immediate corrective saccade.
http://purl.obolibrary.org/obo/HP_0032105	Macrosaccadic oscillations	http://purl.obolibrary.org/obo/HP_0032104	Saccadic oscillation		A type of saccadic oscillations with brief periods of fixation between saccades (intersaccadic interval approximately 200 msec). Macrosaccadic oscillations (up to 40 degrees) straddle the intended fixation position and show a crescendo-decrescendo pattern.
http://purl.obolibrary.org/obo/HP_0032106	Conjunctival icterus	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease.
http://purl.obolibrary.org/obo/HP_0032107	Limbal stem cell deficiency	http://purl.obolibrary.org/obo/HP_0004328	Abnormal anterior eye segment morphology		A condition characterized by a loss or deficiency of the stem cells in the limbus that are vital for re-population of the corneal epithelium and to the barrier function of the limbus.
http://purl.obolibrary.org/obo/HP_0032108	Mildly reduced contrast sensitivity	http://purl.obolibrary.org/obo/HP_0032036	Reduced contrast sensitivity		A mild reduction in the ability to perceive visual contrast characterized by 0.20-0.59 log unit contrast sensitivity loss.
http://purl.obolibrary.org/obo/HP_0032109	Moderately reduced contrast sensitivity	http://purl.obolibrary.org/obo/HP_0032036	Reduced contrast sensitivity		A moderate reduction in the ability to perceive visual contrast characterized by 0.60-0.99 log unit contrast sensitivity loss.
http://purl.obolibrary.org/obo/HP_0032110	Severely reduced contrast sensitivity	http://purl.obolibrary.org/obo/HP_0032036	Reduced contrast sensitivity		A severe reduction in the ability to perceive visual contrast characterized by 1.00 log unit or more contrast sensitivity loss.
http://purl.obolibrary.org/obo/HP_0032111	Abnormal Vistech contrast sensitivity test	http://purl.obolibrary.org/obo/HP_0032036	Reduced contrast sensitivity		An abnormality in perception of contrast as measured by the Vistech wall chart sine wave grating test.
http://purl.obolibrary.org/obo/HP_0032112	Abnormal Pelli Robson contrast sensitivity chart test	http://purl.obolibrary.org/obo/HP_0032036	Reduced contrast sensitivity		An abnormality in perception of contrast as measured by the Pelli-Robson contrast sensitivity chart, which is a large wall-mounted chart, with letters of a fixed size (comprising spatial frequencies appropriate for estimating peak contrast sensitivity) that decrease in contrast.
http://purl.obolibrary.org/obo/HP_0032113	Semidominant inheritance	http://purl.obolibrary.org/obo/HP_0034345	Mendelian inheritance		A mode of inheritance that is observed for traits related to a gene encoded on chromosomes in which a trait can manifest in a monoallelic (e.g. heterozygotes) and biallelic (e.g. homozygotes, compound heterozygotes) state, with similar or differing phenotype severity present dependent on the number of alleles affected.
http://purl.obolibrary.org/obo/HP_0032114	Saccadic intrusion	http://purl.obolibrary.org/obo/HP_0000570	Abnormal saccadic eye movements		An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by a delayed corrective saccade.
http://purl.obolibrary.org/obo/HP_0032116	Macrosquare-wave jerks	http://purl.obolibrary.org/obo/HP_0032114	Saccadic intrusion		Horizontal 10-40 degree excursions from fixation and back again.
http://purl.obolibrary.org/obo/HP_0032118	Retinitis	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		Inflammation of the retina of the eye.
http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology	http://purl.obolibrary.org/obo/HP_0410008	Abnormality of the peripheral nervous system		Any functional abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord.
http://purl.obolibrary.org/obo/HP_0032121	Froment sign	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		An abnormal result of a physical examination of the the hand that tests for palsy of the ulnar nerve. This nerve innervates the adductor pollicis and interossei muscles and thereby enables adduction of the thumb and extension of the interphalangeal joint. An abnormal result consists in reduced functionality and muscular weakness in the pinch grip between the thumb and index finger of the affected hand as the patient attempts to pinch a piece of paper that the examiner tries to pull away. The flexor pollicis longus muscle tries to compensate for the weakness by flexing the tip of the thumb at the interphalangeal joint.
http://purl.obolibrary.org/obo/HP_0032122	Very low visual acuity	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		A reduction in visual acuity with best corrected visual acuity between 1.40 (20/500) and 1.89 logMAR (up to roughly 20/1590).
http://purl.obolibrary.org/obo/HP_0032123	Ultra-low vision	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		Best corrected visual acuity worse than 1.90 logMAR (roughly 20/1590).
http://purl.obolibrary.org/obo/HP_0032124	Abnormal unswitched memory B cell proportion	http://purl.obolibrary.org/obo/HP_0030373	Abnormal memory B cell proportion		Abnormal increase or decrease of the unswitched memory B cell subpopulation, commonly characterized as CD27+IgM+, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032125	Increased unswitched memory B cell proportion	http://purl.obolibrary.org/obo/HP_0032124	Abnormal unswitched memory B cell proportion		Abnormal increase of the unswitched memory B cell subpopulation, commonly characterized as CD27+IgM+, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032126	Decreased unswitched memory B cell proportion	http://purl.obolibrary.org/obo/HP_0032124	Abnormal unswitched memory B cell proportion		Abnormal reduction of the unswitched memory B cell subpopulation, commonly characterized as CD27+IgM+, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032127	Abnormal plasmablast proportion	http://purl.obolibrary.org/obo/HP_0025539	Abnormal B cell subset distribution		Abnormal increase or decrease of plasmablasts, commonly characterized as CD27+CD38hi and sometimes additionally as IgMlowCD24-, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032128	Increased plasmablast proportion	http://purl.obolibrary.org/obo/HP_0032127	Abnormal plasmablast proportion		Abnormal increase of plasmablasts, commonly characterized as CD27+CD38hi and sometimes additionally as IgMlowCD24-, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032129	Decreased plasmablast proportion	http://purl.obolibrary.org/obo/HP_0032127	Abnormal plasmablast proportion		Abnormal decrease of plasmablasts, commonly characterized as CD27+CD38hi and sometimes additionally as IgMlowCD24-, measured as percentage of total B cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032130	Mycobacterium abscessus abscessus infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections.
http://purl.obolibrary.org/obo/HP_0032131	Cervical dysplasia	http://purl.obolibrary.org/obo/HP_0012888	Abnormal uterine cervix morphology		Cervical dysplasia is the precursor to cervical cancer. It is caused by the persistent infection of the human papillomavirus (HPV) into the cervical tissue. Affected cells develop morphologic features with immature basaloid- type squamous cells and mitotic figures in the upper half of the cervical epithelium.
http://purl.obolibrary.org/obo/HP_0032132	Decreased circulating total IgG concentration	http://purl.obolibrary.org/obo/HP_0004315	Decreased circulating IgG concentration		A reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.
http://purl.obolibrary.org/obo/HP_0032133	Transient decreased circulating total IgG concentration	http://purl.obolibrary.org/obo/HP_0032132	Decreased circulating total IgG concentration		A temporary reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.
http://purl.obolibrary.org/obo/HP_0032134	Chronic decreased circulating total IgG concentration	http://purl.obolibrary.org/obo/HP_0032132	Decreased circulating total IgG concentration		A lasting reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.
http://purl.obolibrary.org/obo/HP_0032136	Decreased circulating IgG1 concentration	http://purl.obolibrary.org/obo/HP_0032135	Decreased circulating IgG subclass concentration		A reduction in immunoglobulin levels of the IgG1 subclass in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032137	Decreased circulating IgG3 concentration	http://purl.obolibrary.org/obo/HP_0032135	Decreased circulating IgG subclass concentration		A reduction in immunoglobulin levels of the IgG3 subclass in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032138	Decreased circulating IgG4 concentration	http://purl.obolibrary.org/obo/HP_0032135	Decreased circulating IgG subclass concentration		A reduction in immunoglobulin levels of the IgG4 subclass in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032139	Decreased circulating isohemagglutinin concentration	http://purl.obolibrary.org/obo/HP_0410292	Abnormal circulating isohemagglutinin concentration		Level of isohemagglutinin reduced below expected concentration. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person).
http://purl.obolibrary.org/obo/HP_0032140	Decreased specific antibody response to vaccination	http://purl.obolibrary.org/obo/HP_0012475	Impaired specific antibody response		A reduced ability to synthesize postvaccination antibodies against toxoids and polysaccharides in vaccines, as measured by antibody titer determination following vaccination.
http://purl.obolibrary.org/obo/HP_0032141	Precordial pain	http://purl.obolibrary.org/obo/HP_0100749	Chest pain		A type of chest pain that arises in the or under the left breast and often described as throbbing, stabbing, or burning, and lasting hours or longer. The pain may arise with or after effort, and may spread to the left arm or left side of the neck.
http://purl.obolibrary.org/obo/HP_0032142	Fetor hepaticus	http://purl.obolibrary.org/obo/HP_0100812	Halitosis		Fetor hepaticus is the characteristic breath of patients with severe parenchymal liver disease, which has been said to resemble the odor of a mixture of rotten eggs and garlic.
http://purl.obolibrary.org/obo/HP_0032143	Burning mouth	http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology		An intense sensation of burning, scalding, or tingling feeling of the tongue or other regions of the oral mucosa.
http://purl.obolibrary.org/obo/HP_0032144	Coffee ground vomitus	http://purl.obolibrary.org/obo/HP_0002239	Gastrointestinal hemorrhage		Vomit that has the appearance of coffee grounds, which occurs due to the presence of coagulated blood in the vomit.
http://purl.obolibrary.org/obo/HP_0032145	Sural nerve atrophy	http://purl.obolibrary.org/obo/HP_0045010	Abnormal peripheral nerve morphology by anatomical site		Wasting of the sural nerve, a sensory nerve in the calf region of the leg.
http://purl.obolibrary.org/obo/HP_0032146	HbC hemoglobin	http://purl.obolibrary.org/obo/HP_0011902	Abnormal hemoglobin		Presence of an abnormal type of hemoglobin characterized by the substitution of a glutamic acid residue at position 7 following the initial methionine residue by a lysine (6GAG>6AAG). The presence of HbC can be determined by hemoglobin electrophoresis.
http://purl.obolibrary.org/obo/HP_0032147	Erythromelalgia	http://purl.obolibrary.org/obo/HP_0012531	Pain		Recurrent episodes of redness, burning pain, and warmth of the extremities following exposure to heat or exercise with symptoms predominantly involving the feet.
http://purl.obolibrary.org/obo/HP_0032149	Breakthrough pain	http://purl.obolibrary.org/obo/HP_0032148	Episodic pain		A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain.
http://purl.obolibrary.org/obo/HP_0032150	Paroxysmal rectal pain	http://purl.obolibrary.org/obo/HP_0032148	Episodic pain		Excruciating burning pain in the rectal area that may be triggered by defecation.
http://purl.obolibrary.org/obo/HP_0032151	Episodic eosinophilia	http://purl.obolibrary.org/obo/HP_0001880	Increased total eosinophil count		Recurrent episodes of marked eosinophilia that resolve spontaneously.
http://purl.obolibrary.org/obo/HP_0032152	Keratosis pilaris	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		An anomaly of the hair follicles of the skin that typically presents as small, rough, brown folliculocentric papules distributed over characteristic areas of the skin, particularly the outer-upper arms and thighs.
http://purl.obolibrary.org/obo/HP_0032154	Aphthous ulcer	http://purl.obolibrary.org/obo/HP_0031446	Erosion of oral mucosa		Oral aphthous ulcers typically present as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border.
http://purl.obolibrary.org/obo/HP_0032155	Abdominal cramps	http://purl.obolibrary.org/obo/HP_0002027	Abdominal pain		A type of abdominal pain characterized by a feeling of contractions and typically fluctuating in intensity.
http://purl.obolibrary.org/obo/HP_0032156	Skin detachment	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Loss of sections of skin either spontaneously or after gentle handling.
http://purl.obolibrary.org/obo/HP_0032157	Recurrent genital herpes	http://purl.obolibrary.org/obo/HP_0005353	Recurrent herpes		Recurrent episodes of genital herpes, typically characterized by stages of erythema, papules, short-lived vesicles, painful ulcers, and crusts on the skin of the genitals and surrounding area, and that typically resolve over a period of 2 to 3 weeks.
http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		An unusual infection classified by the affected body part.
http://purl.obolibrary.org/obo/HP_0032159	Fungal meningitis	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		A meningitis caused by fungal infection, with the principal causative organism being Cryptococcus neoformans (cryptococcal meningitis); other causes include Candida and Coccidioides species. A fungal meningitis is most often a manifestation of unusual susceptibility to infection, particularly in severe T-cell deficiencies.
http://purl.obolibrary.org/obo/HP_0032160	Cryptococcal meningitis	http://purl.obolibrary.org/obo/HP_0032159	Fungal meningitis		A type of fungal meningitis caused by an encapsulated yeast that belongs to the genus Cryptococcus. Cryptococcus neoformans and Cryptococcus gattii are responsible for the majority of cases of human cryptococcosis.
http://purl.obolibrary.org/obo/HP_0032161	Coccidioidal meningitis	http://purl.obolibrary.org/obo/HP_0032159	Fungal meningitis		A type of fungal meningitis caused by dissemination of coccidioides to basilar meninges.
http://purl.obolibrary.org/obo/HP_0032162	Unusual skin infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		Increased susceptibility to infection of the skin, nails, or mucous membranes, as manifested by recurrent or severe cutaneous or mucosal infection, or by skin or mucous membrane infection caused by an atypical or opportunistic organism.
http://purl.obolibrary.org/obo/HP_0032163	Unusual molluscum contagiosum	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Molluscum contagiosum is a cutaneous viral infection that is commonly observed in both healthy and immunocompromised children. The infection is caused by a member of the Poxviridae family, the molluscum contagiosum virus. Molluscum contagiosum presents as single or multiple small white or flesh-colored papules that typically have a central umbilication. The central umbilication may be difficult to observe in young children and, instead, may bear an appearance similar to an acneiform eruption. The lesions vary in size (from 1 mm to 1 cm in diameter) and are painless, although a subset of patients report pruritus in the area of infection. On average, 11-20 papules appear on the body during the course of infection and generally remains a self-limiting disease. However, in immunosuppressed patients, molluscum contagiosum can be a severe infection with hundreds of lesions developing on the body. Extensive eruption is indicative of an advanced immunodeficiency state.
http://purl.obolibrary.org/obo/HP_0032164	Increased circulating folate concentration	http://purl.obolibrary.org/obo/HP_0040087	Abnormal circulating folate concentration		The concentration of folic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032165	Placental mesenchymal dysplasia	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Placental mesenchymal dysplasia is a rare anomaly characterized by placentomegaly, dilatation of chorionic vessels and hydropic stem villi with cistern-like formation. It is often clinically mistaken for a partial hydatidiform mole but there is no trophoblastic proliferation. P57 immunohistochemical expression is discordant, showing a normal positive expression in the cytotrophoblastic cells, and loss of expression in the stromal cells.
http://purl.obolibrary.org/obo/HP_0032167	Clostridium difficile enteritis	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		An infection of the small intestine (enteritis) by clostridium difficile.
http://purl.obolibrary.org/obo/HP_0032168	Clostridium difficile colitis	http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection		An infection of the colon (colitis) by clostridium difficile.
http://purl.obolibrary.org/obo/HP_0032169	Severe infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection.
http://purl.obolibrary.org/obo/HP_0032170	Severe varicella zoster infection	http://purl.obolibrary.org/obo/HP_5210116	Unusual VZV infection		An unusually severe form of varicella zoster virus (VZV) infection. In the majority of the cases, especially in children, varicella is a very mild infection characterized by skin lesions, low grade fever and malaise. Severe infection is characterized by manifestations including VZV pneumonia, hepatitis, meningitis, and disseminated varicella.
http://purl.obolibrary.org/obo/HP_0032171	Bladder pain	http://purl.obolibrary.org/obo/HP_0012531	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the urinary bladder. Bladder pain may be more pronounced with a full bladder and relieved upon urination, but this is not always the case.
http://purl.obolibrary.org/obo/HP_0410263	Brain imaging abnormality	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		An anomaly of metabolism or structure of the brain identified by imaging.
http://purl.obolibrary.org/obo/HP_0410266	Visceral hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma arising from within visceral structures, the internal organs of the body.
http://purl.obolibrary.org/obo/HP_0500164	Abnormal blood carbon dioxide level	http://purl.obolibrary.org/obo/HP_0012415	Abnormal blood gas level		An abnormality of carbon dioxide (CO2) in the arterial blood.
http://purl.obolibrary.org/obo/HP_0500165	Abnormal blood oxygen level	http://purl.obolibrary.org/obo/HP_0012415	Abnormal blood gas level		An abnormality of the partial pressure of oxygen in the arterial blood.
http://purl.obolibrary.org/obo/HP_0020073	Hypopigmented macule	http://purl.obolibrary.org/obo/HP_0012733	Macule		A white or lighter patch of skin that may appear anywhere on the body and are caused by decreased skin pigmentation.
http://purl.obolibrary.org/obo/HP_0032179	Abnormal circulating globulin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of globulins in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032180	Abnormal circulating metabolite concentration	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		An abnormal level of an analyte measured in the blood.
http://purl.obolibrary.org/obo/HP_0032199	Abnormal prothrombin time	http://purl.obolibrary.org/obo/HP_0012200	Abnormality of prothrombin		Any deviation from the normal amount of time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.
http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Any deviation from the normal concentration of a metabolite in a tissue.
http://purl.obolibrary.org/obo/HP_0032245	Abnormal metabolism	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		An abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products.
http://purl.obolibrary.org/obo/CL_0011013	motile sperm cell	http://purl.obolibrary.org/obo/CL_0000219	motile cell		A sperm cell that is cabaple of motion (motility).
http://purl.obolibrary.org/obo/CL_0011016	flagellated sperm cell	http://purl.obolibrary.org/obo/CL_0011013	motile sperm cell		A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion.
http://purl.obolibrary.org/obo/HP_0032945	Renal interstitial inflammation	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		Histopathological findings of inflammation of the renal interstitium potentially involving fibrotic as well as non-fibrotic areas, composed of lymphocytes, monocytes, plasma cells.
http://purl.obolibrary.org/obo/HP_0032946	Renal cortical interstitial inflammation	http://purl.obolibrary.org/obo/HP_0032945	Renal interstitial inflammation		Histopathological findings of inflammation of the renal interstitium involving fibrotic as well as non-fibrotic renal cortex, composed of lymphocytes, monocytes, plasma cells.
http://purl.obolibrary.org/obo/HP_0032947	Renal medullary interstitial inflammation	http://purl.obolibrary.org/obo/HP_0032945	Renal interstitial inflammation		Histopathological findings of inflammation of the interstitium of the renal medulla, composed of lymphocytes, monocytes, plasma cells.
http://purl.obolibrary.org/obo/HP_0032948	Renal interstitial fibrosis	http://purl.obolibrary.org/obo/HP_0032581	Abnormal renal interstitial morphology		The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic.
http://purl.obolibrary.org/obo/HP_0032949	Renal interstitial calcium phosphate deposits	http://purl.obolibrary.org/obo/HP_0032644	Renal interstitial deposits		The presence of interstitial aggregates of purple finely granular/laminated calcium- and phosphate deposits.
http://purl.obolibrary.org/obo/HP_0032950	Abnormal renal tubular lumen morphology	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Abnormal structure or form of the lumen (opening) of kidney tubules.
http://purl.obolibrary.org/obo/HP_0032951	Renal tubular viral cytopathic changes	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. Distal tubules are more commonly involved than proximal tubules. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage. Tubular destruction may be associated with necrotizing interstitial granulomas. Severe granulomatous tubulointerstitial nephritis appears to be characteristic of adenoviral infection and is quite rare in other viral infections. Focal wedge-shaped necrosis may occur in renal parenchyma. Immunostaining for adenovirus shows strong nuclear and cytoplasmic staining in infected cells.
http://purl.obolibrary.org/obo/HP_0032952	Usual-type tubular atrophy	http://purl.obolibrary.org/obo/HP_0000092	Renal tubular atrophy		A type of renal tubular atrophy in which the tubules show thick tubular basement membranes lined by small cuboidal or flat cells. Generally accompanied by fibrosis.
http://purl.obolibrary.org/obo/HP_0032953	Renal tubular cytomegalovirus inclusions	http://purl.obolibrary.org/obo/HP_0032951	Renal tubular viral cytopathic changes		Characteristic intranuclear glassy-appearing basophilic inclusions with surrounding halo (owl's eye-type inclusion) and marked increase in the size of the cell (cytomegaly), particularly in tubular epithelial cells and in endothelial cells. Often accompanied by cytopathic changes including patchy interstitial pleomorphic infiltrate with lymphocytes, plasma cells, and macrophages.
http://purl.obolibrary.org/obo/HP_0032954	Renal tubular adenovirus inclusions	http://purl.obolibrary.org/obo/HP_0032951	Renal tubular viral cytopathic changes		Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. The inclusions stain positive for adenovirus (e.g., Figure 3 of PMID:29273157). Distal tubules are more commonly involved than proximal tubules. Occasionally glomerular visceral and parietal epithelial cells can be infected. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage.
http://purl.obolibrary.org/obo/HP_0032955	Renal tubular polyoma virus inclusions	http://purl.obolibrary.org/obo/HP_0032951	Renal tubular viral cytopathic changes		Renal tubular nuclear inclusions have a ground-glass appearance with irregular central clearing, or a coarse, vesicular appearance. Distal tubules are involved more often than proximal tubules. There may be only medullary involvement in early stages, and parietal epithelial cells may be involved in later stages of the infection. Infected epithelial cell nuclei stain with antibody to the large T antigen of the SV40 virus, which serves as a surrogate marker of human polyomavirus infection.
http://purl.obolibrary.org/obo/HP_0032956	Renal tubular herpes simplex virus inclusions	http://purl.obolibrary.org/obo/HP_0032951	Renal tubular viral cytopathic changes		Renal tubular nuclear inclusions that stain positive for herpes simplex virus (HSV). HSV is typically associated with multinucleated giant cells with nuclear inclusions and may cause hemorrhagic interstitial nephritis.
http://purl.obolibrary.org/obo/HP_0032957	Dysmorphic hematuria	http://purl.obolibrary.org/obo/HP_0000790	Hematuria		The presence of dysmorphic urinary erythrocytes. This feature can be observed by phase-contrastmicroscopy, differential interference microscopy, and bright-field microscopy. The acanthocyte or G1 cell, which is a doughnut-shaped cell with one or more blebs, is reported to constitute a special form of dysmorphic erythro-cyte (D cell) specific for glomerular hematuria.
http://purl.obolibrary.org/obo/HP_0032958	Urinary oval fat bodies	http://purl.obolibrary.org/obo/HP_0012614	Abnormal urine cytology		The presence in the urine of desquamated tubular epithelial cells or macrophages filled with lipid droplets.
http://purl.obolibrary.org/obo/HP_0032959	Intratubular calcium oxalate casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		Birefringent calcium- and oxalate-containing casts located within the tubuli of the kidney.
http://purl.obolibrary.org/obo/HP_0032960	Intratubular calcium phosphate casts	http://purl.obolibrary.org/obo/HP_0032623	Renal intratubular casts		Purple and finely granular/laminated calcium- and phosphate-containing casts located within the tubuli of the kidney.
http://purl.obolibrary.org/obo/HP_0032961	Magnesium ammonium phosphate crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		Magnesium ammonium phosphate crystals in the urine.
http://purl.obolibrary.org/obo/HP_0032962	Tubular microcystic change	http://purl.obolibrary.org/obo/HP_0032950	Abnormal renal tubular lumen morphology		Dilated renal tubules (over twice the diameter of a normal proximal tubule) containing eosinophilic amorphous material. This feature is generally accompanied by scalloping of the cast profile. The epithelium lining the microcyst is generally flattened and does not reveal brush border.
http://purl.obolibrary.org/obo/HP_0032963	Complex renal cyst	http://purl.obolibrary.org/obo/HP_0000107	Renal cyst		A renal cyst characterized by epithelium lined space (squamous/columnar) with septations.
http://purl.obolibrary.org/obo/HP_0032964	Uric acid crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		The presence of uric acid crystals in the urine.
http://purl.obolibrary.org/obo/HP_0032965	Interstitial emphysema	http://purl.obolibrary.org/obo/HP_0002097	Emphysema		Interstitial emphysema is characterized by air dissecting within the interstitium of the lung, typically in the peribronchovascular sheaths, interlobular septa, and visceral pleura. It is most commonly seen in neonates receiving mechanical ventilation. It is rarely recognized radiographically in adults and is infrequently seen on CT scans. It appears as perivascular lucent or low attenuating halos and small cysts.
http://purl.obolibrary.org/obo/HP_0032966	Centrilobular emphysema	http://purl.obolibrary.org/obo/HP_0002097	Emphysema		A type of emphysema characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli. This is the commonest form of emphysema in cigarette smokers. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones.
http://purl.obolibrary.org/obo/HP_0032967	Panacinar emphysema	http://purl.obolibrary.org/obo/HP_0002097	Emphysema		Panacinar emphysema involves all portions of the acinus and secondary pulmonary lobule more or less uniformly. It predominates in the lower lobes and is the form of emphysema associated with1-antitrypsin deficiency. CT scans show a generalized decrease of the lung parenchyma with a decrease in the caliber of blood vessels in the affected lung. Severe panacinar emphysema may coexist and merge with severe centrilobular emphysema. The appearance of feature less decreased attenuation may be indistinguishable from severe constrictive obliterative bronchiolitis.
http://purl.obolibrary.org/obo/HP_0032968	Expiratory air trapping	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Abnormal retention of gas within a lung or part of a lung, as a result of airway obstruction of abnormalities in lung compliance. In the classic presentation, the lung will appear normal at inspiration, but on exhalation, the diseased portions of the lung which have lost connective tissue recoil will remain lucent while the healthy portions of the lung will become more dense due to atelectasis. This helps distinguish it from mosaic attenuation due to patchy fibrosis, as occurs with nonspecific interstitial pneumonia, and in early usual interstitial pneumonitis (the hallmark imaging diagnosis of interstitial lung disease) in which there is no change with inspiration and expiration.
http://purl.obolibrary.org/obo/HP_0032969	Traction bronchiectasis	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Distortion of the bronchial airways due to mechanical traction on the bronchi resulting from fibrosis of the surrounding lung parenchyma. CT findings represent irregular bronchial dilatation caused by surrounding retractile pulmonary fibrosis. Dilated airways are usually identifiable as such but may be seen as cysts.
http://purl.obolibrary.org/obo/HP_0032971	Computed tomographic halo sign	http://purl.obolibrary.org/obo/HP_0025179	Ground-glass opacification		CT finding of ground-glass opacity surrounding a nodule or mass. It was first described as a sign of hemorrhage around foci of invasive aspergillosis. The halo sign is nonspecific and may also be caused by hemorrhage associated with other types of nodules or by local pulmonary infiltration by neoplasm.
http://purl.obolibrary.org/obo/HP_0032972	Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025392	Nodular pattern on pulmonary HRCT		A nodular pattern on pulmonary high-resolution computed tomography which are anatomically located centrally within secondary pulmonary lobules. Centrilobular nodules may be dense (i.e., solid) and of homogeneous opacity or ground-glass opacity, and may range from a few millimeters to about 1 cm in size. Because of the similar size of secondary lobules, centrilobular nodules often appear to be evenly spaced. Centrilobular nodules are usually separated from the pleural surfaces, fissures, and interlobular septa by a distance of at least several millimeters. They may appear patchy or diffuse in different diseases.
http://purl.obolibrary.org/obo/HP_0032973	Abnormal bronchoalveolar lavage fluid morphology	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		Abnormal type or counts of nucleated immune cells and acellular components in bronchoalveolar lavage (BAL) fluid. BAL us performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. BAL is commonly used to inform the differential diagnosis of interstitial lung disease or to monitor therapeutic interventions.
http://purl.obolibrary.org/obo/HP_0032974	Abnormal cellular composition of bronchoalveolar fluid	http://purl.obolibrary.org/obo/HP_0032973	Abnormal bronchoalveolar lavage fluid morphology		Deviation from the commonly in healthy people observe cellular distribution. Normal ranges are macrophages over 80%, lymphocytes less than 15%, neutrophils less than 3%, eosinophils less than 0.5%, mast cells less than 0.5%.
http://purl.obolibrary.org/obo/HP_0032975	Abnormal bronchoalveolar fluid protein level	http://purl.obolibrary.org/obo/HP_0032973	Abnormal bronchoalveolar lavage fluid morphology		Any deviation from the normal concentration of protein in the bronchoalveolar fluid.
http://purl.obolibrary.org/obo/HP_0032976	Elevated bronchoalveolar lavage fluid lymphocyte proportion	http://purl.obolibrary.org/obo/HP_0032974	Abnormal cellular composition of bronchoalveolar fluid		Usually, Lymphoycytes make up less than 15% of all cells found in the bronchoalveloar lavage fluid. This elevated cell proportion can be induced by virus or drugs, or is associated with specific diseases.
http://purl.obolibrary.org/obo/HP_0032977	Elevated bronchoalveolar lavage fluid neutrophil proportion	http://purl.obolibrary.org/obo/HP_0032974	Abnormal cellular composition of bronchoalveolar fluid		Usually, Neutrophils make up less than 3% of all cells found in the broncho-alveloar lavage fluid. In children, standard value of neutrophils is higher depending on their age (children under the age of 5 show a maximum value of 10%). This elevated cell proportion is a sign for acute and chronic infections (HP:0012387, HP:0006538) and can be associated to specific diseases.
http://purl.obolibrary.org/obo/HP_0032978	Lipid-laden macrophages in bronchoalveolar fluid	http://purl.obolibrary.org/obo/HP_0032984	Abnormal alveolar macrophage morphology		Accumulation of lipids in alveolar macrophages with droplet-shaped fat inclusions.
http://purl.obolibrary.org/obo/HP_0032979	Hemosiderin-laden macrophages in bronchoalveolar fluid	http://purl.obolibrary.org/obo/HP_0032984	Abnormal alveolar macrophage morphology		Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP).
http://purl.obolibrary.org/obo/HP_0032980	Absent bronchoalveolar surfactant-protein C	http://purl.obolibrary.org/obo/HP_0032975	Abnormal bronchoalveolar fluid protein level		Significantly decreased level or failed detection of surfactant protein C in broncho-alveolar lavage fluid. Comment: Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions, whereas SP-B and SP-C are hydrophobic molecules, which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle. Lack of SP-C may result of surfactant metabolism dysfunction and is also observed in patients with other diffuse parenchymal lung diseases, pathogenetically related to the alveolar surfactant region.
http://purl.obolibrary.org/obo/HP_0032981	Absent bronchoalveolar dimeric surfactant-protein B	http://purl.obolibrary.org/obo/HP_0032975	Abnormal bronchoalveolar fluid protein level		Significantly decreased level or failed detection of surfactant protein B in broncho-alveolar lavage fluid.
http://purl.obolibrary.org/obo/HP_0032983	Atoll sign	http://purl.obolibrary.org/obo/HP_0025179	Ground-glass opacification		CT finding of central ground-glass opacity surrounded by denser consolidation of crescentic shape (forming more than three-fourths of a circle) or complete ring of at least 2 mm in thickness. A rare sign, it was initially reported to be specific for cryptogenic organizing pneumonia, but was subsequently described in patients with paracoccidioidomycosis.
http://purl.obolibrary.org/obo/HP_0032984	Abnormal alveolar macrophage morphology	http://purl.obolibrary.org/obo/HP_0032974	Abnormal cellular composition of bronchoalveolar fluid		Alveolar macrophages usually make up the majority of cells in the bronchoalveolar space (over 80%). The may contain intracellular material depending on underlying diseases or due to exposition to inhaled particles.
http://purl.obolibrary.org/obo/HP_0032985	Dust particle inclusion in alveolar macrophages	http://purl.obolibrary.org/obo/HP_0032984	Abnormal alveolar macrophage morphology		Accumulation of inhaled, nondigestable particles in macrophages.
http://purl.obolibrary.org/obo/HP_0032986	Smoker-inclusions in alveolar macrophages	http://purl.obolibrary.org/obo/HP_0032984	Abnormal alveolar macrophage morphology		In otherwise healthy smokers, characteristic so called smoker-inclusion can be found within the macrophages in the bronchoalveolar fluid. These blue/ black/ round/ oval cytoplasmic inclusions consist of pigmented lipid deposits.
http://purl.obolibrary.org/obo/HP_0032987	Elevated bronchoalveolar lavage fluid eosinophil proportion	http://purl.obolibrary.org/obo/HP_0032974	Abnormal cellular composition of bronchoalveolar fluid		Usually, eosinophils make up less than 0.5% of all cells found in the broncho-alveloar lavage fluid. But in eosinophilic lung disease, the eosinophil cell proportion typically represents more than 25%. Comment: An elevated level of eosinophil cells are also a result of infections, or an allergic reaction or can be drug-induced.
http://purl.obolibrary.org/obo/HP_0032988	Persistent head lag	http://purl.obolibrary.org/obo/HP_0001270	Motor delay		The Premie-Neuro and the Dubowitz Neurological Examination score head lag in the same manner. Scoring for both is as follows: 0 = head drops and stays back, 1 = tries to lift head but drops it back, 2 = able to lift head slightly, 3 = lifts head in line with body, and 4 = head in front of body. This term applies if head lag persists beyond an expected age at a level of 0 or 1. Persistent head lag beyond age 4 mo has been linked to poor outcomes.
http://purl.obolibrary.org/obo/HP_0032989	Delayed ability to roll over	http://purl.obolibrary.org/obo/HP_0002194	Delayed gross motor development		Delayed achievement of the ability to roll front to back and back to front.
http://purl.obolibrary.org/obo/HP_0032990	Localized pulmonary hemorrhage	http://purl.obolibrary.org/obo/HP_0040223	Pulmonary hemorrhage		Circumscribed pulmonary hemorrhage originating from a single bleeding site in the lungs. This can be due to infections, tumorigenesis, foreign bodies, or vascular abnormalities. Patient often feel the site of bleeding, contrast CT scan or angiography may localize the bleeder.
http://purl.obolibrary.org/obo/HP_0032991	Abnormal pulmonary fissure morphology	http://purl.obolibrary.org/obo/HP_4000059	Abnormal lung development		An abnormal form or number of the pulmonary fissures.
http://purl.obolibrary.org/obo/HP_0032992	Abnormal pulmonary fissure architecture	http://purl.obolibrary.org/obo/HP_0032991	Abnormal pulmonary fissure morphology		An abnormal form or location of a pulmonary fissure.
http://purl.obolibrary.org/obo/HP_0032993	Abnormal pulmonary fissure count	http://purl.obolibrary.org/obo/HP_0032991	Abnormal pulmonary fissure morphology		A deviation from the normal number of pulmonary fissures.
http://purl.obolibrary.org/obo/HP_0032994	Supernumerary pulmonary fissure	http://purl.obolibrary.org/obo/HP_0032993	Abnormal pulmonary fissure count		Presence of a lung fissure that does not exist normally. Supernumerary fissures include the superior accessory fissure, the medial basal fissure, the left horizontal fissure, and the azygos fissure form supernumerary lobes.
http://purl.obolibrary.org/obo/HP_0032995	Decreased pulmonary fissure count	http://purl.obolibrary.org/obo/HP_0032993	Abnormal pulmonary fissure count		Lack of one or more of the normal pulmonary fissures.
http://purl.obolibrary.org/obo/HP_0032996	Abnormal circulating cystatin-C concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of cystatin-C in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032997	Decreased circulating cystatin-C concentration	http://purl.obolibrary.org/obo/HP_0032996	Abnormal circulating cystatin-C concentration		The concentration of cystatin-C in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0032998	Elevated circulating cystatin-C concentration	http://purl.obolibrary.org/obo/HP_0032996	Abnormal circulating cystatin-C concentration		The concentration of cystatin-C in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032999	Increased fecal porphyrin	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Abnormally high concentration of fecal porphyrins in feces.
http://purl.obolibrary.org/obo/HP_0033000	Subglottic laryngitis	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		Narrowing of the larynx, commonly occurring during viral respiratory tract infections, in particular in children, leads to symptoms such as hoarseness, a barking cough, stridor, and sometimes dyspnea and respiratory failure.
http://purl.obolibrary.org/obo/HP_0033001	Laryngeal papilloma	http://purl.obolibrary.org/obo/HP_0100605	Neoplasm of the larynx		A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the larynx.
http://purl.obolibrary.org/obo/HP_0033002	Bronchial papilloma	http://purl.obolibrary.org/obo/HP_0030077	Bronchial neoplasm		A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on a bronchus.
http://purl.obolibrary.org/obo/HP_0033003	Tracheal papilloma	http://purl.obolibrary.org/obo/HP_0100551	Neoplasm of the trachea		A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the trachea.
http://purl.obolibrary.org/obo/HP_0033004	Palmar warts	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		Multiple verrucous lesions on the skin of the palm. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by human papillomavirus (HPV).
http://purl.obolibrary.org/obo/HP_0033005	Plantar warts	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		Multiple verrucous lesions on the skin of the sole of the foot. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by caused by human papillomavirus (HPV).
http://purl.obolibrary.org/obo/HP_0033006	Diffuse alveolar damage	http://purl.obolibrary.org/obo/HP_0033137	Abnormal pulmonary alveolar system morphology		Diffuse alveolar damage (DAD) describes a common histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis, and crack cocaine inhalation.
http://purl.obolibrary.org/obo/HP_0033007	Architectural distortion of the lung	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		Architectural distortion is characterized by abnormal displacement of bronchi, vessels, fissures, or septa caused by diffuse or localized lung disease, particularly interstitial fibrosis. This is visible in lung biopsy and CT scans in a distorted appearance and is usually associated with pulmonary fibrosis and accompanied by volume loss.
http://purl.obolibrary.org/obo/HP_0033008	Increased Z-disc width	http://purl.obolibrary.org/obo/HP_0020202	Abnormal Z disk morphology		Abnormally increased width of the Z-disk of the sarcomere, resulting from splitting or opening of the Z-disc (c.f., Figure 2 of PMID:28732005).
http://purl.obolibrary.org/obo/HP_0033009	Increased fecal coproporphyrin 1	http://purl.obolibrary.org/obo/HP_0032999	Increased fecal porphyrin		Abnormally high concentration of coproporphyrin 1 in feces.
http://purl.obolibrary.org/obo/HP_0033010	Increased fecal coproporphyrin 3	http://purl.obolibrary.org/obo/HP_0032999	Increased fecal porphyrin		Abnormally high concentration of coproporphyrin 3 in feces
http://purl.obolibrary.org/obo/HP_0033011	Platystencephaly	http://purl.obolibrary.org/obo/HP_0002683	Abnormal calvaria morphology		Extreme width of the skull in the occipital region, with anterior narrowing and prognathism.
http://purl.obolibrary.org/obo/HP_0033012	Abnormal salivary metabolite concentration	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Any deviation from the normal concentration of a metabolite in saliva.
http://purl.obolibrary.org/obo/HP_0033013	Abnormal salivary cortisol level	http://purl.obolibrary.org/obo/HP_0033012	Abnormal salivary metabolite concentration		Any deviation from the normal concentration of cortisol in saliva.
http://purl.obolibrary.org/obo/HP_0033014	Decreased salivary cortisol level	http://purl.obolibrary.org/obo/HP_0033013	Abnormal salivary cortisol level		Abnormally reduced concentration of cortisol in saliva.
http://purl.obolibrary.org/obo/HP_0033015	Increased salivary cortisol level	http://purl.obolibrary.org/obo/HP_0033013	Abnormal salivary cortisol level		Abnormally elevated concentration of cortisol in saliva.
http://purl.obolibrary.org/obo/HP_0033016	Chronic decreased circulating IgD concentration	http://purl.obolibrary.org/obo/HP_0410245	Decreased circulating IgD concentration		A lasting reduction beneath the normal level of total immunoglobulin D (IgD) in the blood.
http://purl.obolibrary.org/obo/HP_0033017	Transient decreased circulating IgD concentration	http://purl.obolibrary.org/obo/HP_0410245	Decreased circulating IgD concentration		A temporary reduction beneath the normal level of total immunoglobulin D (IgD) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033018	Chronic absent circulating IgD	http://purl.obolibrary.org/obo/HP_0410245	Decreased circulating IgD concentration		A lasting absence of immunoglobulin D (IgD) in the blood, whereby at most trace quantities of IgD can be measured.
http://purl.obolibrary.org/obo/HP_0033019	Male reproductive system neoplasm	http://purl.obolibrary.org/obo/HP_0010787	Genital neoplasm		A neoplasm that affects the male reproductive system.
http://purl.obolibrary.org/obo/HP_0033021	Transient decreased circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0005479	Decreased circulating IgE concentration		A temporary reduction beneath the normal level of total immunoglobulin E (IgE) in the blood.
http://purl.obolibrary.org/obo/HP_0033022	Chronic decreased circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0005479	Decreased circulating IgE concentration		A lasting reduction beneath the normal level of total immunoglobulin E (IgE) in the blood.
http://purl.obolibrary.org/obo/HP_0033023	Chronic absent circulating IgE	http://purl.obolibrary.org/obo/HP_0005479	Decreased circulating IgE concentration		A lasting absence of immunoglobulin E (IgE) in the blood circulation, whereby at most trace quantities of IgE can be measured.
http://purl.obolibrary.org/obo/HP_0033024	Transient decreased circulating IgA concentration	http://purl.obolibrary.org/obo/HP_0002720	Decreased circulating IgA concentration		A temporary reduction beneath the normal level of total immunoglobulin A (IgA) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033025	Chronic absent circulating total IgG	http://purl.obolibrary.org/obo/HP_0032132	Decreased circulating total IgG concentration		A lasting absence of immunoglobulin G (IgG) in the blood, whereby at most trace quantities of IgG can be measured.
http://purl.obolibrary.org/obo/HP_0033026	White oral mucosal macule	http://purl.obolibrary.org/obo/HP_0100669	Abnormal pigmentation of the oral mucosa		A small circumscribed whitish change in the color of the oral mucosa that is neither elevated nor depressed.
http://purl.obolibrary.org/obo/HP_0033027	Retinal peau d'orange	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		A pebbly orange appearance of the fundus that is said to resemble the skin of an orange.
http://purl.obolibrary.org/obo/HP_0046502	Anorgasmia	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of reproductive system physiology		Inability of individual to reach orgasm.
http://purl.obolibrary.org/obo/HP_0046503	Increased libido	http://purl.obolibrary.org/obo/HP_0031845	Abnormal libido		Elevated sexual desire.
http://purl.obolibrary.org/obo/HP_0046504	Decreased libido	http://purl.obolibrary.org/obo/HP_0031845	Abnormal libido		Decreased sexual desire.
http://purl.obolibrary.org/obo/HP_0046505	Hand pain	http://purl.obolibrary.org/obo/HP_0012513	Upper limb pain		An unpleasant sensation characterized by physical discomfort localized to the hand.
http://purl.obolibrary.org/obo/HP_0046507	Bradypnea	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Bradypnea is referring to breathing that is abnormally slow.
http://purl.obolibrary.org/obo/HP_0500265	Increased CD8+ TEMRA T cell proportion	http://purl.obolibrary.org/obo/HP_0410392	Increased memory CD8+ T cell proportion		An increased proportion of CD8-positive effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.
http://purl.obolibrary.org/obo/HP_0500266	Decreased CD8+ TEMRA T cell proportion	http://purl.obolibrary.org/obo/HP_0410385	Decreased memory CD8+ T cell proportion		An decreased proportion of CD8-positive effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.
http://purl.obolibrary.org/obo/HP_0500269	Abnormal gamma-delta T cell proportion	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Abnormal increase or decrease of TCR gamma/delta positive T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0500270	Increased gamma-delta T cell proportion	http://purl.obolibrary.org/obo/HP_0500269	Abnormal gamma-delta T cell proportion		Abnormal increase of TCR gamma/delta positive T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0500271	Decreased gamma-delta T cell proportion	http://purl.obolibrary.org/obo/HP_0500269	Abnormal gamma-delta T cell proportion		Abnormal decrease of TCR gamma/delta positive T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/UBERON_7500046	proximal-most point of head of femur	http://purl.obolibrary.org/obo/UBERON_0006983	anatomical point		The proximal-most point of the head of a femur.
http://purl.obolibrary.org/obo/UBERON_7500047	proximal-most point of head of humerus	http://purl.obolibrary.org/obo/UBERON_0006983	anatomical point		The proximal-most point of the head of a humerus.
http://purl.obolibrary.org/obo/UBERON_7500049	proximal-most point of greater trochanter of femur	http://purl.obolibrary.org/obo/UBERON_0006983	anatomical point		The proximal-most point of the greater trochanter of a femur.
http://purl.obolibrary.org/obo/UBERON_8000006	left side of back	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.
http://purl.obolibrary.org/obo/UBERON_8000007	right side of back	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.
http://purl.obolibrary.org/obo/UBERON_8300000	skin of scalp	http://purl.obolibrary.org/obo/UBERON_0001084	skin of head		A zone of skin that is part of a scalp.
http://purl.obolibrary.org/obo/UBERON_8300001	right forelimb	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A forelimb that is on the right side of a pectoral complex.
http://purl.obolibrary.org/obo/UBERON_8300002	left forelimb	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A forelimb that is on the left side of a pectoral complex.
http://purl.obolibrary.org/obo/UBERON_8300003	right hindlimb	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A hindlimb that is on the right side of a pelvic complex.
http://purl.obolibrary.org/obo/UBERON_8300004	left hindlimb	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		A hindlimb that is on the left side of a pelvic complex.
http://purl.obolibrary.org/obo/PATO_0055003	increased rate of occurrence	http://purl.obolibrary.org/obo/PATO_0050000	rate of occurence		A rate of occurrence that is relatively high.
http://purl.obolibrary.org/obo/CHEBI_176497	geroprotector	http://purl.obolibrary.org/obo/CHEBI_50267	protective agent		Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
http://purl.obolibrary.org/obo/CHEBI_176842	vitamin B9	http://purl.obolibrary.org/obo/CHEBI_75769	B vitamin		Any B-vitamin that exhibits biological activity against vitamin B<small><sub>9</sub></small> deficiency. Vitamin B<small><sub>9</sub></small> refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B<small><sub>9</sub></small> leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B<small><sub>9</sub></small> deficiency include fatigue, muscle weakness, and pale skin.
http://purl.obolibrary.org/obo/CHEBI_176911	fatty acylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		Any O-acylcarnitine in which the acyl group is a fatty acid and the carnitine component has configuration undefined.
http://purl.obolibrary.org/obo/UBERON_8410001	small intestine venule	http://purl.obolibrary.org/obo/UBERON_0001979	venule		Venule of villus of small intestine.
http://purl.obolibrary.org/obo/UBERON_8410002	small intestine lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		A lymphatic vessel that supplies the small intestine.
http://purl.obolibrary.org/obo/UBERON_8410004	small intestine arteriole	http://purl.obolibrary.org/obo/UBERON_0001980	arteriole		Arteriole of villus of small intestine.
http://purl.obolibrary.org/obo/UBERON_8410008	venule of anorectum	http://purl.obolibrary.org/obo/UBERON_0001979	venule		A venule that is located in the anorectum.
http://purl.obolibrary.org/obo/UBERON_8410009	arteriole of anorectum	http://purl.obolibrary.org/obo/UBERON_0001980	arteriole		An arteriole that is located in the anorectum.
http://purl.obolibrary.org/obo/UBERON_8410015	arteriole of colon	http://purl.obolibrary.org/obo/UBERON_0001980	arteriole		An arteriole located in the colon.
http://purl.obolibrary.org/obo/UBERON_8410032	trabecular sinus of lymph node	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		The trabecular sinus is the lymph-filled space outside the trabeculae between lobules of the lymph node. This is a continuation of the subcapsular sinus which receives the afferent vessels and is present beneath the capsule. This space is traversed by both reticular fibers and cells in the lymph.
http://purl.obolibrary.org/obo/UBERON_8410035	medullary arteriole of lymph node	http://purl.obolibrary.org/obo/UBERON_8410042	arteriole of lymph node		An arteriole that arises from the hilar artery of a lymph node and radiates centrifugally, branching in the medulla.
http://purl.obolibrary.org/obo/UBERON_8410036	medullary venule of lymph node	http://purl.obolibrary.org/obo/UBERON_8410041	venule of lymph node		Medullary venules are a continuation of high endothelial venules which condense repeatedly in the interfollicular cortex and peripheral deep cortical unit and then transition to medullary venules at the corticomedullary junction. The medullary venules condense and return centripetally to the hilar vein.
http://purl.obolibrary.org/obo/UBERON_8410041	venule of lymph node	http://purl.obolibrary.org/obo/UBERON_0001979	venule		A venule that is part of a lymph node.
http://purl.obolibrary.org/obo/UBERON_8410042	arteriole of lymph node	http://purl.obolibrary.org/obo/UBERON_0001980	arteriole		An arteriole that is part of a lymph node.
http://purl.obolibrary.org/obo/UBERON_8410043	bronchus submucosal gland	http://purl.obolibrary.org/obo/UBERON_8410077	airway submucosal gland		A submucosal gland located in a bronchus.
http://purl.obolibrary.org/obo/UBERON_8410048	venule of colon	http://purl.obolibrary.org/obo/UBERON_0001979	venule		A venule located in the colon.
http://purl.obolibrary.org/obo/UBERON_8410050	anorectum	http://purl.obolibrary.org/obo/UBERON_0004921	subdivision of digestive tract		A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus.
http://purl.obolibrary.org/obo/UBERON_8410051	lymphatic vessel of colon	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		A lymphatic vessel located in the colon.
http://purl.obolibrary.org/obo/UBERON_8410056	capillary of anorectum	http://purl.obolibrary.org/obo/UBERON_0001982	capillary		A capillary that is part of the anorectum.
http://purl.obolibrary.org/obo/UBERON_8410057	capillary of colon	http://purl.obolibrary.org/obo/UBERON_0001982	capillary		A capillary that is part of the colon.
http://purl.obolibrary.org/obo/GO_0140694	membraneless organelle assembly	http://purl.obolibrary.org/obo/GO_0070925	organelle assembly		The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.
http://purl.obolibrary.org/obo/CL_0009006	enteroendocrine cell of small intestine	http://purl.obolibrary.org/obo/CL_1001598	small intestine secretory cell		An enteroendocrine cell that is located in the small intestine.
http://purl.obolibrary.org/obo/CL_0009037	lymph node mantle zone B cell	http://purl.obolibrary.org/obo/CL_0000236	B cell		A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule.
http://purl.obolibrary.org/obo/CL_0009040	stromal cell of lamina propria of colon	http://purl.obolibrary.org/obo/CL_0009021	stromal cell of lamina propria of large intestine		A stromal cell found in the lamina propria of the colon.
http://purl.obolibrary.org/obo/CL_0009042	enteroendocrine cell of colon	http://purl.obolibrary.org/obo/CL_1001516	intestinal enteroendocrine cell		An enteroendocrine cell that is located in the colon.
http://purl.obolibrary.org/obo/CL_0009043	intestinal crypt stem cell of colon	http://purl.obolibrary.org/obo/CL_0009016	intestinal crypt stem cell of large intestine		An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon.
http://purl.obolibrary.org/obo/CL_0009044	lymphocyte of small intestine lamina propria	http://purl.obolibrary.org/obo/CL_0000542	lymphocyte		A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response.
http://purl.obolibrary.org/obo/CL_0009089	lung pericyte	http://purl.obolibrary.org/obo/CL_0000669	pericyte		A pericyte cell that is part of a lung.
http://purl.obolibrary.org/obo/HP_0034251	Abnormal corneal reflex	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		An anomaly of the corneal reflex that normally induces involuntary blinking of the eyelids following contact of the cornea.
http://purl.obolibrary.org/obo/HP_0034258	Aplasia/Hypoplasia of the midbrain	http://purl.obolibrary.org/obo/HP_0002418	Abnormal midbrain morphology		Absence or underdevelopment of the midbrain (mesencephalon).
http://purl.obolibrary.org/obo/HP_0034261	Aplasia/Hypoplasia of facial bones	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		A developmental defect characterized by absence or underdevelopment of one or more facial bone.
http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		A deep defect in the esophageal, gastric, duodenal or intestinal wall involving the entire mucosal thickness and penetrating through the muscularis mucosae.
http://purl.obolibrary.org/obo/HP_0034281	Phalangeal cone-shaped epiphyses	http://purl.obolibrary.org/obo/HP_0010579	Cone-shaped epiphysis		Cone-shaped epiphyses of the phalanges of the hands or feet. Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery.
http://purl.obolibrary.org/obo/UBERON_8450002	excretory system	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		An anatomical system that eliminates waste products that arise as a result of metabolic activity.
http://purl.obolibrary.org/obo/UBERON_8480029	skin of external genitalia	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		A zone of skin that is part of the external genitalia.
http://purl.obolibrary.org/obo/HP_0034398	Toe deformity	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Abnormal positioning of toe phalanges. Deformities of the lesser toes often occur gradually, though they can be brought on by trauma. The main adult sagittal plane deformities consist of claw toes, hammer toes and mallet toes. Axial plane deformities include crossover toes.
http://purl.obolibrary.org/obo/HP_0034504	Septate gallbladder	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Septate gallbladder is characterized by the presence of a septum that divides the gallbladder in two chambers. When the septum dividing the gallbladder lies longitudinally it is called bilobed gallbladder and when there is a transverse septum separating the fundus from the rest of the gallbladder it is called an hour-glass gallbladder.
http://purl.obolibrary.org/obo/HP_0034396	Hippocampal malrotation	http://purl.obolibrary.org/obo/HP_0025100	Abnormal hippocampus morphology		Hippocampal malrotation, also termed incomplete inversion of the hippocampus or hippocampal malformation, is an increasingly recognized neuroimaging finding of undetermined clinical significance. It is characterized by features including (i) Round or pyramidal shape instead of ovoid shape; (ii) Medial position of the hippocampus on the hippocampal sulcus; (iii) The collateral sulcus is excessively deep or verticalized; (iv) Fimbria located medial to the hippocampus; (v) Small or displaced fornix; (vi) Enlarged temporal horn and empty choroid fissure; (vii) Thickened subiculum; (viii) Reduced upper horizontal portion of the parahippocampal gyrus.
http://purl.obolibrary.org/obo/HP_0034397	Claw toe deformity	http://purl.obolibrary.org/obo/HP_0034398	Toe deformity		Claw toes are characterized by hyperextension at the metatarsal-phalangeal joints and flexion of the interphalangeal joints.
http://purl.obolibrary.org/obo/HP_0034399	Prolonged central motor conduction time	http://purl.obolibrary.org/obo/HP_0012079	Abnormality of central motor conduction		Increased duration of the central motor conduction time (CMCT). The CMCT estimates the conduction time of corticospinal fibers between motor cortex and spinal (or bulbar) motoneurons. It includes the times for excitation of cortical cells, conduction via the corticobulbar-corticospinal tract and excitation of the motoneuron sufficient to reach its firing threshold. CMCT is calculated by subtracting the peripheral conduction time from the MEP latency recorded after cortical stimulation.
http://purl.obolibrary.org/obo/HP_0034400	Circumferential skin creases on extremities	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Ringed creases of the skin of the extremities related to folding of excess skin.
http://purl.obolibrary.org/obo/HP_0034401	Atypical teratoid/rhabdoid tumor	http://purl.obolibrary.org/obo/HP_0002898	Embryonal neoplasm		An aggressive malignant embryonal neoplasm arising from the central nervous system. It is composed of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm. Mutations of the SMARCB1 gene or very rarely SMARCA4 (BRG1) gene are present. The vast majority of cases occur in childhood. Symptoms include lethargy, vomiting, cranial nerve palsy, headache, and hemiplegia.
http://purl.obolibrary.org/obo/HP_0034402	Rhabdoid tumor of the kidney	http://purl.obolibrary.org/obo/HP_0034557	Rhabdoid tumor		A highly aggressive, extremely rare neoplasm of the kidney that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers, and pathologic diagnosis requires familiarity with these microscopic features plus awareness that adult onset is possible. It can be associated with abnormalities of chromosome 22. It is characterized by the presence of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm.
http://purl.obolibrary.org/obo/HP_0034403	Subcutaneous panniculitis-like T-cell lymphoma	http://purl.obolibrary.org/obo/HP_0012190	T-cell lymphoma		A form of T-cell non-Hodgkin lymphoma in which cytotoxic CD8+ T cells infiltrate adipose tissue forming subcutaneous nodules.
http://purl.obolibrary.org/obo/HP_0034404	Fungal hyphae in sputum	http://purl.obolibrary.org/obo/HP_0032016	Abnormal sputum		Presence of hyphae (long, branching, filamentous structures produced by fungi) in sputum.
http://purl.obolibrary.org/obo/HP_0034405	Enlarged tectum	http://purl.obolibrary.org/obo/HP_0002363	Abnormal brainstem morphology		Increasaed size of the tectum, which is the region of the midbrain posterior to the cerebral aqueduct of Sylvius. The midbrain is the most superior portion of the brainstem.
http://purl.obolibrary.org/obo/HP_0034407	Reduced circulating 3-ketoacyl-CoA thiolase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Decreased concentration of 3-ketoacyl-CoA thiolase in th blood circulation.
http://purl.obolibrary.org/obo/HP_0034408	Solitary angiokeratoma	http://purl.obolibrary.org/obo/HP_0001014	Angiokeratoma		A dark, keratotic papule about 2-10 mm in diameter, usually occurring on the lower extremeities. Usually the lesions begin as bright, soft, and nonkeratotic paules which grow larger and change to a firm, blue to black and keratotic stage.
http://purl.obolibrary.org/obo/HP_0034409	Fordyce angiokeratoma	http://purl.obolibrary.org/obo/HP_0001014	Angiokeratoma		A type of angiokeratoma that most commonly occurs on the scrotum of patients who are 40 years old or older. The typical single lesion is a dark red to blue dome-shaped papule 2-4 mm in diameter with a very discrete keratotic surface. Typically, they are multiple and arranged in a line parallel to the raphe mediana of the scrotum. They also occur on the vulva and less commnly on the penis.
http://purl.obolibrary.org/obo/HP_0034410	Angiokeratoma circumscriptum naeviforme	http://purl.obolibrary.org/obo/HP_0001014	Angiokeratoma		A type of angiokeratoma that typically presents in childhood as a large, mostly linear and unilateral hyperkeratotic plaque which is composed of confluent keratotic papules. The size ranges from a few centimeters up to a major part of the body surface. Initially the lesions present as multiple reddish macules, clinically similar to a nevus flammeus. Within several years they develop into acanthokeratotic papules that agrregate into plaques which may have a hyperkeratotic surface.
http://purl.obolibrary.org/obo/HP_0034411	Angiokeratoma of Mibelli	http://purl.obolibrary.org/obo/HP_0001014	Angiokeratoma		A type of angiokeratoma that typically presents in women on the dorsa of fingers and toes and multiple dark red papules with a slightly verrucous surface, each measuring about 3-5 mm in diameter.
http://purl.obolibrary.org/obo/HP_0034412	Laryngeal mass	http://purl.obolibrary.org/obo/HP_0025423	Abnormal larynx morphology		A lump in the region of the larynx. A mass is any lump in the body that can be caused by the abnormal growth of cells, a cyst, hormonal changes or an immune reaction. Typically a mass is an initial finding that will lead to additional workup. Laryngeal masses can be visualized by multiple methods include computed tomography.
http://purl.obolibrary.org/obo/HP_0034413	Palate mass	http://purl.obolibrary.org/obo/HP_0000174	Abnormal palate morphology		A lump in the region of the palate. A mass is any lump in the body that can be caused by the abnormal growth of cells, a cyst, hormonal changes or an immune reaction. Typically a mass is an initial finding that will lead to additional workup.
http://purl.obolibrary.org/obo/HP_0034414	Thick oral frenulum	http://purl.obolibrary.org/obo/HP_0000190	Abnormal oral frenulum morphology		Increased thickness of an oral frenulum, flaps of mucous membrane that extend from the midline gingiva to the upper or lower lip.
http://purl.obolibrary.org/obo/HP_0034415	Tooth avulsion	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		A type of dental trauma characterized by total dislocation of the tooth from its socket.
http://purl.obolibrary.org/obo/HP_0034416	Torn oral frenulum	http://purl.obolibrary.org/obo/HP_0000190	Abnormal oral frenulum morphology		Laceration or tear of an oral frenulum, flaps of mucous membrane that extend from the midline gingiva to the upper or lower lip.
http://purl.obolibrary.org/obo/HP_0034417	Intraoral laceration	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		A wound of the mucosa within the oral cavity covering lips, tongue, palate, gingiva, pharynx, or retropharynx.
http://purl.obolibrary.org/obo/HP_0034418	Erythematous oral mucosa	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		An erythematous lesion of the oral mucosa may result from a variety of tissue alterations, including inflammation, erythrocyte extravasation, and atrophy or reduced keratinization of the surface epithelium.
http://purl.obolibrary.org/obo/HP_0034419	Mitral chordae tendinae rupture	http://purl.obolibrary.org/obo/HP_0025523	Abnormal morphology of the chordae tendinae of the mitral valve		Breakage of the chordae tendinae of the mitral valve. This can lead to loss of tension of one of the mitral valve leaflets and mitral regurgitation.
http://purl.obolibrary.org/obo/HP_0034420	History of cardiovascular procedure	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		Indicates that a cardiovascular procedure such as stenting, bypass, catherization was performed on a patient.
http://purl.obolibrary.org/obo/HP_0034421	Ejection click	http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound		A high-pitched sound that occurs at the moment of maximal opening of the aortic or pulmonary valves. They are heard just after the first heart sound. The sounds occur in the presence of a dilated aorta or pulmonary artery or in the presence of a bicuspid or flexible stenotic aortic or pulmonary valve. Ejection clicks may also be called ejection sounds.
http://purl.obolibrary.org/obo/HP_0034422	Cryofibrinogenemia	http://purl.obolibrary.org/obo/HP_0011898	Abnormality of circulating fibrinogen		Cryofibrinogen is an abnormal protein that forms precipitate only in plasma. consisting of fibrinogen, fibronectin, alpha1-antitrypsin and alpha2-macroglobulin.
http://purl.obolibrary.org/obo/HP_0034423	Triggered by allergens	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about by exposure to allergens.
http://purl.obolibrary.org/obo/HP_0034424	Clicking tinnitus	http://purl.obolibrary.org/obo/HP_0000360	Tinnitus		A type of tinnitus that presents as clicks, resembling the noise made by the snapping together of 2 fingers.
http://purl.obolibrary.org/obo/HP_0034425	Reduced hair sulfur content	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		Abnormally low amount of sulfur in hair.
http://purl.obolibrary.org/obo/HP_0034426	Chromhidrosis	http://purl.obolibrary.org/obo/HP_0000971	Abnormal sweat gland morphology		Secretion of colored sweat.
http://purl.obolibrary.org/obo/HP_0034427	Purulent eye discharge	http://purl.obolibrary.org/obo/HP_0100533	Inflammatory abnormality of the eye		Secretion of pus-like (purulent) material from the eye, which may caused the eyelids to be matted together.
http://purl.obolibrary.org/obo/HP_0034428	Megaloblepharon	http://purl.obolibrary.org/obo/HP_0000492	Abnormal eyelid morphology		Disproportionately large eyelids
http://purl.obolibrary.org/obo/HP_0034429	Bacteria in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0034747	CSF infectious agent		Presence of bacteria in the cerebrospinal fluid, as manifested by visual inspection or bacterial culture results.
http://purl.obolibrary.org/obo/HP_0034431	Joint crepitus	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		A popping, clicking or crackling sound that accompaniees movement of a joint.
http://purl.obolibrary.org/obo/HP_0034432	Intertriginous distribution	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to the localization of a skin lesion involving any area of the body where two opposing skin surfaces can touch and rub or chaff.
http://purl.obolibrary.org/obo/HP_0034433	Distributed along skin tension lines	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to the localization of a skin lesion that correspond to skin tension lines, which are linear clefts in the skin that indicate the direction of orientation of the underlying collagen fibers. Skin tension lines are also known as Langer's lines or lines of cleavage.
http://purl.obolibrary.org/obo/HP_0034436	Gaze avoidance	http://purl.obolibrary.org/obo/HP_0034435	Abnormal eye contact		A deliberate avoidance of eye contact.
http://purl.obolibrary.org/obo/HP_0034437	Excessive eye contact	http://purl.obolibrary.org/obo/HP_0034435	Abnormal eye contact		Tendency to maintain sustained eye contact for an inappropriately long period of time.
http://purl.obolibrary.org/obo/HP_0034438	Balanitis	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		Inflammation of glans penis
http://purl.obolibrary.org/obo/HP_0034439	Instep location	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that is situated in the arched middle portion of the foot in front of the ankle joint (i.e., instep).
http://purl.obolibrary.org/obo/HP_0034440	Ameliorated by ultraviolet light exposure	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a skin lesion that is improved or made more bearable by exposure to ultraviolet light (sunshine or phototherapy).
http://purl.obolibrary.org/obo/HP_0034441	Decreased circulating aspartic acid concentration	http://purl.obolibrary.org/obo/HP_0500158	Abnormal circulating aspartic acid concentration		An reduced concentration of aspartic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034443	Reduced circulating erythropoietin concentration	http://purl.obolibrary.org/obo/HP_0034442	Abnormal circulating erythropoietin concentration		Decreased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production.
http://purl.obolibrary.org/obo/HP_0034445	Reduced gamma-glutamyltransferase level	http://purl.obolibrary.org/obo/HP_0034444	Abnormal gamma-glutamyltransferase level		Decreased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.
http://purl.obolibrary.org/obo/HP_0034446	Elevated circulating histamine concentration	http://purl.obolibrary.org/obo/HP_0033405	Abnormal circulating organic amino compound concentration		Increased concentration of histamine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034447	Increased circulating interleukin 18 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		An increased concentration of interleukin-18 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034448	Abnormal phytanic acid:pristanic acid ratio	http://purl.obolibrary.org/obo/HP_0010964	Abnormal circulating long-chain fatty-acid concentration		Any deviation from the normal ratio of blood phytanic acid concentration to pristanic acid concentration.
http://purl.obolibrary.org/obo/HP_0034449	Increased phytanic acid:pristanic acid ratio	http://purl.obolibrary.org/obo/HP_0034448	Abnormal phytanic acid:pristanic acid ratio		An elevation above the normal ratio of blood phytanic acid concentration to pristanic acid concentration.
http://purl.obolibrary.org/obo/HP_0034450	Decreased phytanic acid:pristanic acid ratio	http://purl.obolibrary.org/obo/HP_0034448	Abnormal phytanic acid:pristanic acid ratio		A reduction below the normal ratio of blood phytanic acid concentration to pristanic acid concentration.
http://purl.obolibrary.org/obo/HP_0034451	Rectovesical fistula	http://purl.obolibrary.org/obo/HP_0100590	Rectal fistula		An aberrant, pathological communication between the rectum and the bladder.
http://purl.obolibrary.org/obo/HP_0034452	Rectoureteral fistula	http://purl.obolibrary.org/obo/HP_0100590	Rectal fistula		An abnormal connection (fistula) between the rectum and the ureter.
http://purl.obolibrary.org/obo/HP_0034453	Hypoplastic umbilicus	http://purl.obolibrary.org/obo/HP_0001551	Abnormal umbilicus morphology		Underdevelopment of the umbilicus.
http://purl.obolibrary.org/obo/HP_0034454	Arachnoid granulation	http://purl.obolibrary.org/obo/HP_0100700	Abnormal arachnoid mater morphology		Arachnoid granulations (AGs) are tufts of arachnoid membrane invaginated into the dural sinuses through which cerebrospinal fluid (CSF) enters the venous system. The lesions are primarily located in the parasagittal region along the superior sagittal sinus, which is occasionally seen at the transverse sinus. Normally dural venous sinus AGs typically range from 2 to 8 mm in size, but may grow enough to expand the dural sinuses, and even the inner table, diploic space and outer table of the skull.
http://purl.obolibrary.org/obo/HP_0034455	Increased CSF taurine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Increased concentration of taurine in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0034456	Elevated circulating glutathione concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An abnormally increased level of glutathione in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034457	Hawkinsinuria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of hawkinsin in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034458	Elevated urinary phenylpyruvic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An abnormally increased amount of phenylpyruvic acid in the urine.
http://purl.obolibrary.org/obo/HP_0034459	Ameliorated by lumbar puncture	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by lumbar puncture.
http://purl.obolibrary.org/obo/HP_0034460	Increased CSF uracil concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		An increased level of uracil in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0034461	Elevated urine kynurenine level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An abnormally increased amount of kynurenine in the urine.
http://purl.obolibrary.org/obo/HP_0034462	Increased CSF L-alloisoleucine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		An abnormally increased concentration of L-alloisoleucine in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0034463	Hydroxylysinemia	http://purl.obolibrary.org/obo/HP_0010908	Abnormal circulating lysine concentration		An increased concentration of hydroxylysine in the blood circulation. Hydroxylysine arises from a post-translational hydroxy modification of lysine and is unique to collagen and proteins containing collagen-like sequences. Elevated concentrations of hydroxylysine may indicate increased bone turnover.
http://purl.obolibrary.org/obo/HP_0034464	Homocitrullinuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		An increased amount of L-homocitrulline in the urine. L-homocitrulline is an L-lysine derivative that is L-lysine having a carbamoyl group at the N(6)-position. It is found in individuals with urea cycle disorders.
http://purl.obolibrary.org/obo/HP_0034465	2-hydroxyadipic aciduria	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of 2-hydroxyadipic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034466	Homoargininuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		An increased amount of homoarginine in the urine. Homoarginine is a nonproteinogenic alpha amino acid.
http://purl.obolibrary.org/obo/HP_0034467	Increased urinary cysteine level	http://purl.obolibrary.org/obo/HP_0033095	Increased sulfur amino acid level in urine		An increased concentration of cysteine in the urine.
http://purl.obolibrary.org/obo/HP_0034468	Gastric xanthoma	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		Gastric xanthomas (also known as xanthelasmas) are are plaque-like red lesions defined by the presence of histiocytic containing lipids.
http://purl.obolibrary.org/obo/HP_0034469	Decreased stool elastase level	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Reduced amount of pancreatic elastase in the stool. This feature may be observed with pancreatic insufficiency.
http://purl.obolibrary.org/obo/HP_0034470	Elevated stool chloride content	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Elevated amount of chloride in the stool.
http://purl.obolibrary.org/obo/HP_0034471	Increased fecal coproporphyrin III:coproporphyrin I ratio	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Abnormal relative increase in the amount of fecal coproporphyrin III as compared to coproporphyrin I in the feces.
http://purl.obolibrary.org/obo/HP_0034472	Increased fecal harderoporphyrin	http://purl.obolibrary.org/obo/HP_0032999	Increased fecal porphyrin		Abnormally high concentration of harderoporphyrin in feces.
http://purl.obolibrary.org/obo/HP_0034473	Increased fecal heptacarboxylporphyrin	http://purl.obolibrary.org/obo/HP_0032999	Increased fecal porphyrin		Abnormally high concentration of heptacarboxylporphyrin in feces.
http://purl.obolibrary.org/obo/HP_0034474	Increased fecal pentacarboxylporphyrin	http://purl.obolibrary.org/obo/HP_0032999	Increased fecal porphyrin		Abnormally high concentration of pentacarboxylporphyrin in feces.
http://purl.obolibrary.org/obo/HP_0034475	Increased fecal isocoproporphyrin	http://purl.obolibrary.org/obo/HP_0032999	Increased fecal porphyrin		Abnormally high concentration of isocoproporphyrin in feces.
http://purl.obolibrary.org/obo/HP_0034476	Positive fecal Clostridium botulinum test	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Identification of Clostridium botulinum toxin in the feces.
http://purl.obolibrary.org/obo/HP_0034477	Perihepatic adhesions	http://purl.obolibrary.org/obo/HP_0002585	Abnormal peritoneum morphology		Abnormal union of the membranous surfaces of the liver capsule and the parietal peritoneum due to inflammation or injury. Adhesions may be visualized by laparoscopy and may have a violin string appearance.
http://purl.obolibrary.org/obo/HP_0034478	Dilated vas deferens	http://purl.obolibrary.org/obo/HP_0012872	Abnormal vas deferens morphology		Abnormal increase in diameter (expansion) of the vas deferens.
http://purl.obolibrary.org/obo/HP_0034479	Enlarged epididymis	http://purl.obolibrary.org/obo/HP_0009714	Abnormal epididymis morphology		Abnormal increase in the size of the epididymis.
http://purl.obolibrary.org/obo/HP_0034481	Atypical gestures	http://purl.obolibrary.org/obo/HP_4000090	Abnormal gesture use		Spontaneous production of communicative gestures that are perceived as odd or mechanical, or are poorly integrated with other means of communication. This may include inaccurate mimicry of typical gestures.
http://purl.obolibrary.org/obo/HP_0034483	Bone marrow vacuolated lymphocytes	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		The presence of lymphocytes with multilple vacuoles (a membrane-bound cell organelle) in the bone marrow.
http://purl.obolibrary.org/obo/HP_0034484	Spinal cord calcifications	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		The presence of calcium deposition in the spinal cord.
http://purl.obolibrary.org/obo/HP_0034485	Neuroepithelial cyst	http://purl.obolibrary.org/obo/HP_0100835	Benign neoplasm of the central nervous system		A benign epithelial-lined cystic lesion that can occur anywhere in the neuraxis. Neuroepithelial cysts are ependymal or epithelial lined fluid collections of unknown etiology within the central nervous system parenchyma with no obvious ventricular or subarachnoid connection. Most cysts are asymptomatic, however, some present with seizures, mass effect, or rarely with movement disorders. On imaging, they present as CSF-like parenchymal cysts with smooth, rounded borders and minimal or no surrounding signal intensity abnormality.
http://purl.obolibrary.org/obo/HP_0034486	Reduced circulating interleukin 7 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		A diminished concentration of interleukin-7 in the circulation.
http://purl.obolibrary.org/obo/HP_0034487	Increased circulating interleukin 12 concentration	http://purl.obolibrary.org/obo/HP_6000442	Abnormal circulating interleukin 12 concentration		An increased concentration of interleukin-12 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034488	Increased circulating interleukin 13 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		An increased concentration of interleukin-13 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034489	Increased circulating interleukin 2 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		An increased concentration of interleukin-2 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034490	Increased circulating interleukin 4 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		An increased concentration of interleukin-4 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034491	Increased circulating interleukin 5 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		An increased concentration of interleukin-5 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034492	Salpingitis	http://purl.obolibrary.org/obo/HP_0011027	Abnormal fallopian tube morphology		An inflammation of the fallopian tube.
http://purl.obolibrary.org/obo/HP_0034493	Tubo-ovarian abscess	http://purl.obolibrary.org/obo/HP_0100592	Peritoneal abscess		A tubo-ovarian abscess (TOA) is a complex infectious mass of the adnexa that forms as a sequela of pelvic inflammatory disease.
http://purl.obolibrary.org/obo/HP_0034494	Opacified paranasal sinuses	http://purl.obolibrary.org/obo/HP_0000245	Abnormal paranasal sinus morphology		White appearance (radio-opaqueness) of a paranasal sinus on radiography.
http://purl.obolibrary.org/obo/HP_0034495	Elevated brain glutamine level by MRS	http://purl.obolibrary.org/obo/HP_0034496	Abnormal brain glutamine level by MRS		An increased in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS).
http://purl.obolibrary.org/obo/HP_0034497	Increased urinary hexanoic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of hexanoic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034498	Hepatic focal nodular hyperplasia	http://purl.obolibrary.org/obo/HP_0002896	Neoplasm of the liver		Hepatic focal nodular hyperplasia (FNH) is a benign hepatic tumor. FNH develops within hepatic parenchymal tissue that is otherwise histologically normal. Macroscopically, the tumor is characterized by the presence of depressed, grayish-white scar, which is generally (but not always) located at the center of the lesion, with fibrous septa radiating outward, toward the periphery of the tumor. This stellate scar is found in only 50% of all FNH nodules, but its presence is regarded as pathognomonic. The lesion itself is usually lighter in color than the tissue that surrounds it, and it sometimes has a yellowish hue. FNH nodules are generally not capsulated; their margins are well defined, and they are sometimes lobulated.
http://purl.obolibrary.org/obo/HP_0034499	Increased bone marrow iron	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		An increased amount of iron in the bone marrow.
http://purl.obolibrary.org/obo/HP_0034500	Glenoid fracture	http://purl.obolibrary.org/obo/HP_0041245	Fractured shoulder bone		A fracture of the glenoid fossa, a relatively shallow dish is located on the lateral scapula and is the socket portion of the shoulder joint that meets to articulate the humeral head.
http://purl.obolibrary.org/obo/HP_0034501	Widened mediastinum	http://purl.obolibrary.org/obo/HP_0045026	Abnormal mediastinum morphology		Abnormal increase in the width of the mediastinum, often defined as being greater than 6 to 8 cm.
http://purl.obolibrary.org/obo/HP_0034502	Narrow mediastinum	http://purl.obolibrary.org/obo/HP_0045026	Abnormal mediastinum morphology		Abnormal decrease in the width of the mediastinum.
http://purl.obolibrary.org/obo/HP_0034503	Ovarian torsion	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		Ovarian torsion is a twisting of the ligaments that support the adnexa, cutting off the blood flow to the ovary.
http://purl.obolibrary.org/obo/HP_0034505	Gallbladder wall thickening	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Abnormal increased in the thickness of the wall of the gallbladder.
http://purl.obolibrary.org/obo/HP_0034506	Gallbladder enlargement	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Abnormal increased in the thickness of the size of the gallbladder.
http://purl.obolibrary.org/obo/HP_0034507	Gallbladder mass	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		An abnormal lesion or swelling seen on gallbladder imaging.
http://purl.obolibrary.org/obo/HP_0034508	Fingerprint bodies	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Fingerprint bodies are inclusion bodies located at the periphery of the muscle fibers underneath the sarcolemma (subsarcolemmal), consisting of non-membrane-bound packed lamellae arranged in concentric patterns resembling fingerprints.
http://purl.obolibrary.org/obo/HP_0034509	Spheroid bodies	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		An accumulation of myofilamentous material within individual muscle fibers, forming usually round but occasionally elongated bodies ranging from 2 to 15 pm in size. The so-called spheroid bodies stain green with the modified trichrome preparation and are mainly present in the periphery of type 1 muscle fibers, where they may occupy large sectors sharply demarcated from the remainder of the cross-sectioned muscle fiber.
http://purl.obolibrary.org/obo/HP_0034510	Abnormal muscle tissue enzyme activity or level	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Any deviation from the normal activity or histological staining of an enzyme in muscle tissue, usually measured in a muscle biopsy specimen.
http://purl.obolibrary.org/obo/HP_0034511	Reduced muscle aconitase activity	http://purl.obolibrary.org/obo/HP_0034510	Abnormal muscle tissue enzyme activity or level		Diminished activity of the enzyne aconitase in muscle tissue.
http://purl.obolibrary.org/obo/HP_0034512	Transitional-cell carcinoma of the ureter	http://purl.obolibrary.org/obo/HP_0100516	Neoplasm of the ureter		A cancer of the ureter that most often arises in the distal third of the ureter and is often diagnosed during the sixth and seventh decades of life. The most common presentation is gross hematuria or flank pain.
http://purl.obolibrary.org/obo/HP_0034513	Increased circulating Interferon-alpha concentration	http://purl.obolibrary.org/obo/HP_0011116	Abnormal circulating interferon concentration		An elevation in the concentration of interferon alpha measured in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034514	Liver hamartoma	http://purl.obolibrary.org/obo/HP_0010566	Hamartoma		A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the liver.
http://purl.obolibrary.org/obo/HP_0034515	Ameloblastoma	http://purl.obolibrary.org/obo/HP_0100612	Odontogenic neoplasm		Ameloblastoma is a benign odontogenic tumor generally present in the jaw bone. The tumor originates from the residual epithelium of the tooth germ, epithelium of odontogenic cysts stratified squamous epithelium and epithelium of the enamel organ.
http://purl.obolibrary.org/obo/HP_0034516	Ameliorated by ketogenic diet	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by following a ketogenic diet.
http://purl.obolibrary.org/obo/CL_4033049	taste receptor cell of tongue	http://purl.obolibrary.org/obo/CL_0002319	neural cell		A taste receptor cell that is part of a taste bud of a tongue.
http://purl.obolibrary.org/obo/UBERON_8600012	submucosal gland acinus	http://purl.obolibrary.org/obo/UBERON_0014717	mucous acinus		A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium.
http://purl.obolibrary.org/obo/HP_0035015	Elevated circulating short-chain acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0045045	Elevated circulating acylcarnitine concentration		Concentration of short-chain acylcarnitine in the blood circulation above the upper limit of normal. Acylcarnitines are classified according to the number of carbon atoms in the acyl-chain. Short chain acylcarnitines have between two and five carbon atoms in the acyl-chain (C2-C5),
http://purl.obolibrary.org/obo/HP_0035016	Elevated circulating C4-acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035015	Elevated circulating short-chain acylcarnitine concentration		The concentration of C4-acylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0045045	Elevated circulating acylcarnitine concentration		Concentration of medium-chain acylcarnitine in the blood circulation above the upper limit of normal. Acylcarnitines are classified according to the number of carbon atoms in the acyl-chain. Medium-chain acylcarnitines have between six and twelve carbon atoms in the acyl-chain (C6-C12),
http://purl.obolibrary.org/obo/HP_0035018	Elevated circulating long-chain acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0045045	Elevated circulating acylcarnitine concentration		Concentration of long-chain acylcarnitine in the blood circulation above the upper limit of normal. Acylcarnitines are classified according to the number of carbon atoms in the acyl-chain. Long-chain acylcarnitines have between thirteen and twenty carbon atoms in the acyl-chain (C13-C20),
http://purl.obolibrary.org/obo/HP_0035019	Elevated circulating C5 acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035015	Elevated circulating short-chain acylcarnitine concentration		Concentration of C5 acylcarnitines in the blood circulation above the upper limit of normal. C5 acylcarnitines have a five-carbon acyl chain.
http://purl.obolibrary.org/obo/HP_0035020	Elevated circulating C18 acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035018	Elevated circulating long-chain acylcarnitine concentration		Concentration of C18 acylcarnitines in the blood circulation above the upper limit of normal. C18 acylcarnitines have a eighteen-carbon acyl chain.
http://purl.obolibrary.org/obo/HP_0035021	Elevated circulating C16 acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035018	Elevated circulating long-chain acylcarnitine concentration		Concentration of C16 acylcarnitines in the blood circulation above the upper limit of normal. C16 acylcarnitines have a sixteen-carbon acyl chain.
http://purl.obolibrary.org/obo/HP_0035022	Elevated circulating very long-chain acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0045045	Elevated circulating acylcarnitine concentration		Concentration of very long-chain acylcarnitine in the blood circulation above the upper limit of normal. Acylcarnitines are classified according to the number of carbon atoms in the acyl-chain. Very long-chain acylcarnitines have twentyone or more carbon atoms in the acyl-chain (C21 and higher),
http://purl.obolibrary.org/obo/HP_0035023	Elevated circulating acetylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035015	Elevated circulating short-chain acylcarnitine concentration		Concentration of acetylcarnitine (C2 acylcarnitine) in the blood circulation above the upper limit of normal. Acetylcarnitine has a two-carbon acyl chain.
http://purl.obolibrary.org/obo/HP_0035024	Elevated circulating methylmalonylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035016	Elevated circulating C4-acylcarnitine concentration		Concentration of methylmalonylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035025	Elevated circulating 3-hydroxyhexadecanoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035021	Elevated circulating C16 acylcarnitine concentration		Concentration of 3-hydroxyhexadecanoylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035026	Elevated circulating C6 acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration		Concentration of C6 acylcarnitines in the blood circulation above the upper limit of normal. C6 acylcarnitines have a six-carbon acyl chain.
http://purl.obolibrary.org/obo/HP_0035027	Elevated circulating methylglutarylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035026	Elevated circulating C6 acylcarnitine concentration		The concentration of O-methylglutarylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035028	Elevated circulating 3-hydroxyisovalerylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035019	Elevated circulating C5 acylcarnitine concentration		Concentration of 3-hydroxyisovalerylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035029	Elevated circulating 3-hydroxyhexanoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035026	Elevated circulating C6 acylcarnitine concentration		Concentration of 3-hydroxyhexanoylcarnitine (C6-OH) in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035030	Elevated circulating carnitine concentration	http://purl.obolibrary.org/obo/HP_0010967	Abnormal circulating carnitine concentration		Concentration of carnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035031	Elevated circulating tiglylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035019	Elevated circulating C5 acylcarnitine concentration		Concentration of tiglylcarnitine (C5:1) in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0035032	Reduced circulating acetylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033445	Reduced circulating acylcarnitine concentration		Concentration of acetylcarnitine (C2 acylcarnitine) in the blood circulation below the lower limit of normal. Acetylcarnitine has a two-carbon acyl chain.
http://purl.obolibrary.org/obo/HP_0035033	Decreased circulating octadecenoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033445	Reduced circulating acylcarnitine concentration		The concentration of octadecenoylcarnitine (C18:1 acylcarnitine) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_5200204	Disturbed perception with a stimulus	http://purl.obolibrary.org/obo/HP_5200202	Abnormal interpretation of external stimuli		A perceptual experience in which an individual's perception of sensory stimuli is altered or disrupted in some way, resulting in abnormal or distorted sensory perceptions despite the presence of actual external stimuli.
http://purl.obolibrary.org/obo/HP_5200242	Cognitive distortion	http://purl.obolibrary.org/obo/HP_0025785	Abnormal preoccupation		A cognitive distortion is a maladaptive, exaggerated, or irrational thought pattern.
http://purl.obolibrary.org/obo/HP_5200283	Sleep-related breathing disorders	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		Conditions of abnormal and difficult respiration during sleep, including chronic snoring and sleep apnea.
http://purl.obolibrary.org/obo/HP_5200297	Abnormal transition from wakefulness to sleep	http://purl.obolibrary.org/obo/HP_5200293	Sleep-wake transition abnormality		Abnormal transition of consciousness from wakefulness to sleep.
http://purl.obolibrary.org/obo/HP_5200406	Tactile agnosia	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		The inability to recognize objects by touch is called tactile agnosia.
http://purl.obolibrary.org/obo/GO_0160307	protein biosynthetic process	http://purl.obolibrary.org/obo/GO_0009059	macromolecule biosynthetic process		The chemical reactions and pathways resulting in the formation of protein.
http://purl.obolibrary.org/obo/GO_0180064	protein O-linked glycosylation via xylose	http://purl.obolibrary.org/obo/GO_0006493	protein O-linked glycosylation		A glycoprotein biosynthetic process starting with the covalent linkage of a xylose via a beta-glycosidic bond to the oxygen atom of a serine or a threonine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan.
http://purl.obolibrary.org/obo/CL_4052061	epidermal keratinocyte	http://purl.obolibrary.org/obo/CL_0000362	epidermal cell		A keratinocyte of the skin epidermis that synthesizes keratin and undergoes successive stages of differentiation as it migrates from the basal layer to the cornified (stratum corneum) layer. These differentiation stages include the basal, spinous (prickle), and granular cell layers. This cell is central to epidermal homeostasis, mediating wound healing, immune modulation, including the secretion of cytokines and chemokines that recruit neutrophils (Simmons and Gallo, 2024), and intercellular communication with adjacent melanocytes (Marrapodi and Bellei, 2024).
http://purl.obolibrary.org/obo/CL_4052058	Merkel cell of epidermis	http://purl.obolibrary.org/obo/CL_0000362	epidermal cell		A Merkel cell found mainly in the basal layer of the epidermis and the outer root sheath of hair follicles, particularly concentrated in areas with high tactile acuity, such as touch domes, hair follicles, and fingertips.
http://purl.obolibrary.org/obo/HP_0020007	Abnormal affect regulation	http://purl.obolibrary.org/obo/HP_0025766	Abnormal affect		A disturbance in the processes by which emotional responses are initiated, modulated, sustained, or terminated in a contextually appropriate manner. Abnormal affect regulation involves maladaptive patterns in the generation, intensity, or control of affective experience and expression, leading to inconsistent, excessive, or insufficient modulation of emotion relative to situational demands.
http://purl.obolibrary.org/obo/HP_0025288	Excessive sleep	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		A clinical phenomenon characterized by sleeping longer than what is typical or necessary for a person's age and context, or by recurrent episodes of sleep that intrude upon the waking hours. Excessive sleep is identified through self-reports or observations and may involve prolonged nighttime sleep, frequent daytime naps, or episodes of unintentional sleep.
http://purl.obolibrary.org/obo/HP_4000063	Sleep related hallucination	http://purl.obolibrary.org/obo/HP_5200293	Sleep-wake transition abnormality		Hallucination during onset/falling asleep in any sensory modality, usually auditory, visual, or tactile.
http://purl.obolibrary.org/obo/HP_6001302	Aphakia	http://purl.obolibrary.org/obo/HP_0000517	Abnormal lens morphology		Absence of the crystalline lens in the eye, which may be congenital or acquired (e.g., following surgical removal of the lens for cataracts or trauma).
http://purl.obolibrary.org/obo/HP_0020001	Clinical anophthalmos	http://purl.obolibrary.org/obo/HP_0000528	Anophthalmia		Congenital anophthalmos is a rare ocular anomaly in which histologically detectable eyeball structures are absent due to poor development of the primary optic nerve vesicle. However, with appropriate imaging or intraoperatively, rudimentary remains of this structure can usually be detected. Therefore, the term clinical congenital anophthalmos seems more appropriate and denotes a phenotypic range between microphthalmos and anophthalmos.
http://purl.obolibrary.org/obo/HP_0020002	Ileal stricture	http://purl.obolibrary.org/obo/HP_0001549	Abnormal ileum morphology		A pathological narrowing of the ileum that is caused by the development of a ring of scar tissue that constricts the ileal lumen.
http://purl.obolibrary.org/obo/HP_0020003	Embryo developmental arrest	http://purl.obolibrary.org/obo/HP_0033335	Abnormal preimplantation embryonic development		A failure of an embryo to progress through the early stages of preimplantation development (typically from fertilization, i.e., 1-cell zygote, to blastocyst on day 5-6), and is used clinically when embryos fail to reach transferable stages in assisted reproductive technologies (ARTs) such in vitro fertilization (IVF). Arrested embryo development is characterized by downregulation of metabolic activity and cessation of cell division. In order for an embryo to be characterized as non-viable, i.e., arrested, it should present with a lack of cleaving activity and fail to show a sign of mitotic cellular division for at least 24 hours. One can observe failure of a zygote to cleave, cleavage stage arrest either on day 2 or day 3 when the embryo is expected to be between the 2 and 8-cell stage, failure to compact to morula, or failure to form a blastocyst.
http://purl.obolibrary.org/obo/HP_0020004	Abnormal CSF guanidinoacetic acid concentration	http://purl.obolibrary.org/obo/HP_0500184	Abnormal CSF amino acid concentration		The concentration of guanidinoacetic acid in the cerebrospinal fluid (CSF) is outside the limits of normal.
http://purl.obolibrary.org/obo/HP_0020005	Decreased CSF guanidinoacetic acid concentration	http://purl.obolibrary.org/obo/HP_0020004	Abnormal CSF guanidinoacetic acid concentration		The concentration of guanidinoacetic acid in the cerebrospinal fluid (CSF) is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025002	Abnormal cecum morphology	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		A structural anomaly of the cecum, which is the proximal blind pouch of the ascending colon, is located at the ileocecal junction in the right iliac fossa.
http://purl.obolibrary.org/obo/HP_0025003	Flail chest	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		Flail chest is a physical exam finding that can be present in the setting of chest wall trauma or injury. When multiple adjacent ribs are fractured in 2 or more places, this can create a focal "free-floating" segment of the chest wall that moves independently from the rest of the chest.
http://purl.obolibrary.org/obo/HP_0025036	Type I radial ray deficiency	http://purl.obolibrary.org/obo/HP_0006433	Radial ray deficiency		A type of radial ray deficiency characterized by short distal radius. The distal radial epiphysis is present but delayed in appearance. The growth of the distal radial epiphysis is decreased causing a normal appearing but short radius. There is little radial deviation of the hand due to adequate radial carpal support. The radius has normal proximal epiphyseal growth. Thumb hypoplasia is almost always present.
http://purl.obolibrary.org/obo/HP_0025054	Type II radial ray deficiency	http://purl.obolibrary.org/obo/HP_0006433	Radial ray deficiency		A type of radial ray deficiency characterized by a hypoplastic radius. The radius has both proximal and distal epiphyses but growth is defective in both. This type is essentially a radius in miniature. Growth of the radius proceeds at a decreased rate.
http://purl.obolibrary.org/obo/HP_0025055	Type III radial ray deficiency	http://purl.obolibrary.org/obo/HP_0006433	Radial ray deficiency		A type of radial ray deficiency characterized by partial absence of the radius. The radius is partially absent. The defect can be in the proximal, middle, or distal third. All have been reported , but the most frequent is the absence of the distal one or two thirds. The hand is radially displaced . The ulna is thickened, shortened , and bowed radially, and the wrist is unsupported.
http://purl.obolibrary.org/obo/HP_0025056	Type IV radial ray deficiency	http://purl.obolibrary.org/obo/HP_0006433	Radial ray deficiency		A type of radial ray deficiency characterized by total absence of the radius. This represents the most common type of radial deficiency. The hand is unsupported and is usually severely radially displaced.
http://purl.obolibrary.org/obo/HP_0025067	Recurrent sepsis	http://purl.obolibrary.org/obo/HP_0100806	Sepsis		Repeated bouts of sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.
http://purl.obolibrary.org/obo/HP_0025091	Wrist sign	http://purl.obolibrary.org/obo/HP_0100807	Long fingers		The wrist sign is positive when the tip of the thumb covers the entire fingernail of the fifth finger when wrapped around the contralateral wrist.
http://purl.obolibrary.org/obo/HP_0025111	Acquired aphakia	http://purl.obolibrary.org/obo/HP_6001302	Aphakia		Absence of the crystalline lens in the eye known to be the result of a non-congenital condition, e.g., following surgical removal of the lens for cataracts or trauma.
http://purl.obolibrary.org/obo/HP_0025120	Abnormal circulating reverse T3 concentration	http://purl.obolibrary.org/obo/HP_0031508	Abnormal circulating thyroid hormone concentration		Concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation is ouside of the limits of normal.
http://purl.obolibrary.org/obo/HP_0025183	Abnormal total CD4+ T cell number	http://purl.obolibrary.org/obo/HP_0025540	Abnormal T cell subset number		Abnormal increase or decrease of absolute number of helper CD3+CD4+ T cells (either count per volume or percentage of total lymphocytes), compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
http://purl.obolibrary.org/obo/HP_0025184	Arousal parasomnia	http://purl.obolibrary.org/obo/HP_0025234	Parasomnia		An altered state of arousal during sleep that may be reported by the individual or an observation of others.
http://purl.obolibrary.org/obo/HP_0025187	Sleep talking	http://purl.obolibrary.org/obo/HP_5200300	Abnormal movement during sleep		Vocalization (production of recognizable words or other sounds) during sleep with lack of awareness.
http://purl.obolibrary.org/obo/HP_0025189	Hypnic jerks	http://purl.obolibrary.org/obo/HP_5200300	Abnormal movement during sleep		Hypnic jerks are characterized by sudden and brief (less than 1 second), non-periodic simultaneous contractions of the whole body or one or more extremities at the onset of sleep.
http://purl.obolibrary.org/obo/HP_4000064	Poor sleep	http://purl.obolibrary.org/obo/HP_0002360	Sleep disturbance		Subjectively or observationally reported sleep that is insufficiently restorative, disrupted, or of inadequate quality, regardless of duration. Poor sleep may involve difficulty maintaining sleep continuity, frequent awakenings, a sense of light or shallow sleep, or waking up feeling unrefreshed. It is typically identified through self-report or clinical interview and not by objective measurements.
http://purl.obolibrary.org/obo/HP_0025298	Extended nighttime sleep	http://purl.obolibrary.org/obo/HP_0025288	Excessive sleep		Sleeping for a longer duration than usual during the night.
http://purl.obolibrary.org/obo/HP_0025299	Frequent napping	http://purl.obolibrary.org/obo/HP_0025288	Excessive sleep		Regular episodes of sleep that occur during the day outside of the main sleep period.
http://purl.obolibrary.org/obo/HP_0025365	Free-running sleep pattern	http://purl.obolibrary.org/obo/HP_0006979	Sleep-wake cycle disturbance		A condition in which the intrinsic circadian rhythm is no longer entrained to the 24-h schedule. Normal individuals who are exposed to an environment devoid of zeitgebers develop free-running rhythms with a period longer than 24 h.
http://purl.obolibrary.org/obo/HP_6001274	Thumb sign	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		The distal phalanx of the adducted thumb extends beyond the ulnar border of the palm (The thumb protrudes from the clenched fist).
http://purl.obolibrary.org/obo/HP_6001275	Tibialis anterior tendon rupture	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Partial or complete breakage (rupture) of the tibialis anterior tendon (TAT). The TAT is the principal dorsiflexor of the ankle joint and secondary invertor of the foot. It has important roles in the different stages of gait; in the swing phase, it concentrically dorsiflex the ankle for foot clearance and during plantarflexion of the ankle in the stance phase, it eccentrically contract to stabilize the ankle and prevent damage to the foot and ankle. Clinically, presentations in acute lacerations or direct trauma cases are straight forward, in chronic and atraumatic cases usually the symptoms at the time of TAT rupture are more subtle. Other manifestations include mild pain, localized mass, palpable gap, loss of strength, instability during gait, gait disturbances with forefoot dropping and stumbling and high stepping gait.
http://purl.obolibrary.org/obo/HP_6001276	Decreased circulating ADAMTS13 activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Activity of the enzyme von Willebrand factor-cleaving protease (ADAMTS13) in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001277	Abnormal methacholine challenge test	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		An abnormal result of the methacholine challenge test, which is a bronchoprovocation technique used to evaluate airway hyperresponsiveness, particularly in patients with suspected asthma.
http://purl.obolibrary.org/obo/HP_6001278	Positive stool glutamate dehydrogenase test	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Detection of the presence of glutamate dehydrogenase produced by Clostridium difficile in a stool sample.
http://purl.obolibrary.org/obo/HP_6001279	Retrocorneal membrane	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		A retrocorneal membrane is an abnormal, fibrous or cellular tissue layer that forms on the posterior surface of the cornea, typically on or adjacent to the Descemet membrane. It may result from trauma, surgery (e.g., penetrating keratoplasty), inflammation, or endothelial cell dysfunction, and can lead to visual impairment depending on its density and extent.
http://purl.obolibrary.org/obo/HP_6001280	Adrenal hemorrhage	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Adrenal hemorrhage is bleeding within the capsule of the adrenal gland.
http://purl.obolibrary.org/obo/HP_6001281	Optic nerve sheath dilatation	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		An abnormal increase in the diameter of the optic nerve sheath, typically due to elevated intracranial pressure or local pathology affecting cerebrospinal fluid (CSF) dynamics. It can be detected via imaging modalities such as ultrasound or MRI and may be associated with papilledema, idiopathic intracranial hypertension, or optic nerve tumors.
http://purl.obolibrary.org/obo/HP_6001282	Right ventricular thrombus	http://purl.obolibrary.org/obo/HP_0001707	Abnormal right ventricle morphology		A blood clot (thrombus) localized in the right ventricle.
http://purl.obolibrary.org/obo/HP_6001283	Severe Candida infection	http://purl.obolibrary.org/obo/HP_0020101	Invasive fungal infection		Increased susceptibility to Candida infections as manifested by a severe or invasive infection with Candida. Severe manifestations include invasive candidiasis with hematogenous spread (candidaemia), hepatosplenic candidiasis, renal candidiasis, Candida endophthalmitis, and Candida endocarditis.
http://purl.obolibrary.org/obo/HP_6001284	Phrenic neuropathy	http://purl.obolibrary.org/obo/HP_0032120	Abnormal peripheral nervous system physiology		A functional deficit of the phrenic nerve. Phrenic neuropathy (PhN) is a debilitating condition characterized by impairment of the diaphragm muscle, the primary inspiratory muscle. Diaphragm muscle ultrasound is a noninvasive tool that appears to offer both high sensitivity and specificity for diagnosis. Alternatively, electrodiagnostic studies can assess phrenic nerve health. PhN is commonly diagnosed via diaphragm muscle US or fluoroscopy (sniff test) with paradoxical or significantly decreased diaphragm muscle movement.
http://purl.obolibrary.org/obo/HP_6001285	Glomerular basement membrane subendothelial remodeling	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		New glomerular basement membrane matrix formation under the endothelial cell.
http://purl.obolibrary.org/obo/HP_6001286	Glomerular endothelium swelling	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		Enlargement of the glomerular endothelium (the innermost layer of the glomerular filtration barrier) causing capillary lumen narrowing and loss of fenetrations.
http://purl.obolibrary.org/obo/HP_6001287	Medullary collecting duct ectasia	http://purl.obolibrary.org/obo/HP_0004742	Abnormal renal collecting system morphology		Widening of the lumen of the lumen of the collecting ducts in the renal medulla.
http://purl.obolibrary.org/obo/HP_6001289	Corneal keloid	http://purl.obolibrary.org/obo/HP_0011495	Abnormal corneal epithelium morphology		A raised, opaque, and fibrous lesion on the cornea resembling a dermal keloid, typically composed of disorganized collagen and fibrovascular tissue. Corneal keloids can impair vision and are often secondary to trauma, surgery, or underlying congenital disorders.
http://purl.obolibrary.org/obo/HP_6001290	Podocytic mitochondrial proliferation	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		An ultrastructural abnormality of the kidney glomeruli characterized by an excessive number or abnormal aggregation of mitochondria in podocytes.
http://purl.obolibrary.org/obo/HP_6001291	Elevated vitamin D metabolite ratio	http://purl.obolibrary.org/obo/HP_0100511	Abnormal circulating vitamin D concentration		The ratio of 24,25(OH)2D to 25(OH)D (also known as vitamin D metabolite ratio or VMR) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001292	Aggravated by vitamin D supplementation	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by treatment or supplementation with vitamin D.
http://purl.obolibrary.org/obo/HP_6001293	Aggravated by sun exposure	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that becomes worse with exposure to sunlight.
http://purl.obolibrary.org/obo/HP_6001294	Tubular accumulation of uromodulin	http://purl.obolibrary.org/obo/HP_0032950	Abnormal renal tubular lumen morphology		Accumulation of uromodulin within renal tubular cells or lumina.
http://purl.obolibrary.org/obo/HP_6001295	Elevated stool reducing substances	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Elevated level of reducing substances in the feces. If carbohydrate malabsorption is suspected, a reducing substance should be investigated in the stool using the Benedict or Fehling test. The presence of reducing substances may indicate an abnormality in carbohydrate (e.g., sucrose, lactase) metabolism. The unabsorbed sugars in stool are measured as reducing substances.
http://purl.obolibrary.org/obo/HP_6001296	Osteochondral lesion of talus	http://purl.obolibrary.org/obo/HP_0008365	Abnormal talus morphology		Osteochondral lesion of the talus (OLT) is an injury involving the articular cartilage and subchondral bone, defined as any damage involving both articular cartilage and subchondral bone of the talar dome. OLT can cause ankle joint pain and can sometimes lead to instability and manifest as an area of abnormal, damaged cartilage and bone on the top of the talus bone (the lower bone of the ankle joint).
http://purl.obolibrary.org/obo/HP_6001297	Mallet toe	http://purl.obolibrary.org/obo/HP_0034398	Toe deformity		A mallet toe involves the distal interphalangeal (DIP) joint [such that] the distal phalanx is flexed on the middle phalanx.
http://purl.obolibrary.org/obo/HP_6001298	Bunionette deformity	http://purl.obolibrary.org/obo/HP_0008089	Abnormality of the fifth metatarsal bone		The bunionette, or tailor's bunion, is a lateral prominence of the fifth metatarsal head. Most commonly, bunionettes are the result of a widened 4-5 intermetatarsal angle with associated varus of the metatarsophalangeal joint.
http://purl.obolibrary.org/obo/HP_6001299	Elevated CSF beta chorionic gonadotropin concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		The concentration of beta chorionic gonadotropin in the cerebrospinal fluid (CSF) is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001300	Pigment epithelium detachment	http://purl.obolibrary.org/obo/HP_0007703	Abnormal retinal pigmentation		Separation of the retinal pigment epithelium (RPE) from the underlying Bruch membrane.
http://purl.obolibrary.org/obo/HP_6001301	Retinal gliosis	http://purl.obolibrary.org/obo/HP_0000546	Retinal degeneration		A pathological condition characterized by the proliferation of glial cells in the retina, often occurring as a reactive response to injury, inflammation, or degenerative changes, and typically resulting in structural and functional alterations in the retina.
http://purl.obolibrary.org/obo/HP_6001303	Pain on thumb extension	http://purl.obolibrary.org/obo/HP_0046505	Hand pain		An unpleasant sensation characterized by physical discomfort that is triggered upon extension (straightening) of the thumb.
http://purl.obolibrary.org/obo/HP_6001304	Fractured lunate bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the lunate bone.
http://purl.obolibrary.org/obo/HP_6001305	Fractured triquetrum bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the triquetrum bone.
http://purl.obolibrary.org/obo/HP_6001306	Fractured pisiform bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the pisiform bone.
http://purl.obolibrary.org/obo/HP_6001307	Fractured trapezium bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the trapezium bone.
http://purl.obolibrary.org/obo/HP_6001308	Fractured trapezoid bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the trapezoid bone.
http://purl.obolibrary.org/obo/HP_6001309	Fractured capitate bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the capitate bone.
http://purl.obolibrary.org/obo/HP_6001310	Fractured hamate bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the hamate bone.
http://purl.obolibrary.org/obo/HP_6001311	Pulsatile abdominal mass	http://purl.obolibrary.org/obo/HP_0031500	Abdominal mass		An abnormal enlargement or swelling in the abdomen that pulses or throbs.
http://purl.obolibrary.org/obo/HP_6001312	Nonpulsatile abdominal mass	http://purl.obolibrary.org/obo/HP_0031500	Abdominal mass		An abnormal enlargement or swelling in the abdomen that does not pulse or throb.
http://purl.obolibrary.org/obo/HP_6001313	Iatrogenic anophthalmos	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		A form of acquired anophthalmos resulting from surgical removal of the eye (enucleation or evisceration), typically performed due to trauma, intraocular tumors, intractable pain in a blind eye, or severe infection. Unlike congenital anophthalmos, the orbit may have previously developed normally and prosthetic rehabilitation is often pursued.
http://purl.obolibrary.org/obo/HP_6001314	Reduced erythrocyte glutathione peroxidase	http://purl.obolibrary.org/obo/HP_0030272	Abnormal erythrocyte enzyme concentration or activity		Activity or concentration of in the level of glutathione peroxidase (EC 1.11.1.9) in erythrocytes below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001315	Elevated circulating malonyl carnitine concentration	http://purl.obolibrary.org/obo/HP_0010966	Abnormal circulating fatty acid anion concentration		The concentration of malonylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001316	Sertoli cell hypoplasia	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		Abnormal decrease in the number of Sertoli cells in the testis.
http://purl.obolibrary.org/obo/HP_6001317	Positive talar tilt test	http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology		An abnormal result of the talar tilt test. This test assesses ankle ligament integrity, particularly the calcaneofibular ligament (CFL) and the deltoid ligaments. To perform the test, the foot is placed at an angle of 90 degrees with the leg, the calcaneofibular ligament is perpendicular and the anterior talofibular ligament is parallel to the long axis of the talus. Therefore, inversion in this position results in strain on the calcaneofibular ligament.
http://purl.obolibrary.org/obo/HP_6001318	Plantar ecchymosis	http://purl.obolibrary.org/obo/HP_0031364	Ecchymosis		A purpuric lesion that is larger than 1 cm in diameter and is located on the sole of the foot.
http://purl.obolibrary.org/obo/HP_6001319	Prolonged exposure to axillary pressure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of prolonged compressive pressure in the axillary region.
http://purl.obolibrary.org/obo/HP_6001320	Lateral ankle pain	http://purl.obolibrary.org/obo/HP_0030840	Ankle pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the outer side of the ankle.
http://purl.obolibrary.org/obo/HP_6001321	Medial ankle pain	http://purl.obolibrary.org/obo/HP_0030840	Ankle pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the inner side of the ankle.
http://purl.obolibrary.org/obo/HP_6001322	Posterior ankle pain	http://purl.obolibrary.org/obo/HP_0030840	Ankle pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back of the ankle.
http://purl.obolibrary.org/obo/HP_6001323	Anterior ankle pain	http://purl.obolibrary.org/obo/HP_0030840	Ankle pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the front of the ankle.
http://purl.obolibrary.org/obo/HP_6001324	Exacerbated by colchicine	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by treatment with colchizine.
http://purl.obolibrary.org/obo/HP_6001325	Retinal periphlebitis	http://purl.obolibrary.org/obo/HP_6001165	Abnormal retinal vein morphology		A condition characterized by inflammation of the outer walls of retinal veins, often presenting as vascular sheathing or exudates along the venous walls.
http://purl.obolibrary.org/obo/HP_6001326	Purulent pericardial effusion	http://purl.obolibrary.org/obo/HP_0001698	Pericardial effusion		Elevated leukocyte count in the pericardial fluid ranging from a a microscopic purulent pericardial effusion to gross pus in the pericardial space.
http://purl.obolibrary.org/obo/HP_6001327	Conjunctival erosion	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		A condition characterized by the localized loss or breakdown of the conjunctival epithelium, often resulting in exposure of the underlying tissue. Conjunctival erosion may cause symptoms such as redness, irritation, foreign body sensation, and tearing. It can result from trauma, chemical injuries, ocular surface diseases, or prolonged use of contact lenses.
http://purl.obolibrary.org/obo/HP_6001328	Positive Mycobacterium tuberculosis sputum culture	http://purl.obolibrary.org/obo/HP_0430107	Sputum infectious agent		Growth of mycobacterium tuberculosis in a sputum culture.
http://purl.obolibrary.org/obo/HP_6001329	Increased external rotation of shoulder	http://purl.obolibrary.org/obo/HP_0430047	Large joint hypermobility		Increased rotation of the lower part of the arm away from the body (tested with the elbow flexed and the elbow held next to the side of the body or shoulder 90 degrees abducted to the side).
http://purl.obolibrary.org/obo/HP_6001330	Positive trunk flexion test	http://purl.obolibrary.org/obo/HP_0001382	Joint hypermobility		The proband is asked to flex the trunk forward with knees straight. The result of the test is considered positive (abnormal) if the palms can be made to rest flat on the floor.
http://purl.obolibrary.org/obo/HP_6001331	Tibiotalar arthritis	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		AP, oblique, or lateral view x-ray of the ankle showing radiographic evidence of osteoarthritis such as joint space narrowing, subchondral sclerosis, subchondral cysts, and/or osteophyte formation in the tibiotalar joint.
http://purl.obolibrary.org/obo/HP_6001332	Anterior ankle osteophyte	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Imaging study of the ankle revealing osteophyte (bone spur) formation at the anterior aspect of the ankle (tibial or talar neck).
http://purl.obolibrary.org/obo/HP_6001333	Midfoot arthritis	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		AP, oblique, or lateral view x-ray of the foot showing radiographic evidence of osteoarthritis in the midfoot (tarsometatarsal (TMT) joints, naviculocuneiform joint, intercuneiform joints, and/or metatarsal cuneiform joints), such as joint space narrowing, subchondral sclerosis, subchondral cysts, and/or osteophyte formation in the tibiotalar joint.
http://purl.obolibrary.org/obo/HP_6001334	Decreased circulating reverse T3 concentration	http://purl.obolibrary.org/obo/HP_0025120	Abnormal circulating reverse T3 concentration		Concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001335	Stocking-glove distribution	http://purl.obolibrary.org/obo/HP_0012838	Localized		Distribution of findings in hands and feet with a distal to proximal gradient of severity (being more severe in the more distal locations).
http://purl.obolibrary.org/obo/HP_6001336	Hairy kidney sign	http://purl.obolibrary.org/obo/HP_0012210	Abnormal renal morphology		A radiological sign related to infiltration of histiocytes into the kidneys and perirenal fat. This infiltration, along with thickening of fibrous bands within the perirenal fat, creates a hairy appearance on cross-sectional imaging studies.
http://purl.obolibrary.org/obo/HP_6001337	White appearance of duodenal mucosa	http://purl.obolibrary.org/obo/HP_0002246	Abnormal duodenum morphology		On a typical diet (e.g., no dietary fat restriction), the intestinal mucosa may have a gelee blanche or white hoar frosting appearance on endoscopy.
http://purl.obolibrary.org/obo/HP_6001338	Acromioclavicular joint separation	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		An acromioclavicular (AC) joint joint separation, often called a shoulder separation, is a dislocation of the clavicle from the acromion. This feature is ascertainable radiographically by AC joint x-ray views including bilateral anteroposterior (AP) view, axillary lateral view, and/or Zanca view showing either superior, posterior, or inferior displacement of the distal clavicle in relation to the acromion at the AC joint.
http://purl.obolibrary.org/obo/HP_6001339	Acromioclavicular joint arthritis	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		Degenerative disease of the acromioclavicular (AC) joint that manifests radiographically as Zanca view X-ray of the AC joint showing radiographic evidence of osteoarthritis such as joint space narrowing, subchondral sclerosis, subchondral cysts, and/or osteophyte formation in the AC joint.
http://purl.obolibrary.org/obo/HP_6001340	Positive shoulder cross-body adduction test	http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology		A test used with suspected chronic acromioclavicular joint lesions (which are a common source of pain and disability in the shoulder). The test is considered positive with pain in the ipsilateral acromioclavicular joint when patient straightens the affected arm forward and reaches for the contralateral shoulder with extra manual cross body (adduction) pressure on the arm from the examiner.
http://purl.obolibrary.org/obo/HP_6001341	Proximal humeral epiphysiolysis	http://purl.obolibrary.org/obo/HP_0010598	Abnormality of the proximal humeral epiphysis		Proximal humeral epiphysiolysis (Little League shoulder) is a shear or stress injury of the epiphyseal cartilage of the proximal humerus. Anteroposterior (AP) view of the shoulder in external rotation showing widening of the proximal humerus physis in comparison to contralateral shoulder with possible metaphyseal bony irregularity.
http://purl.obolibrary.org/obo/HP_6001342	Positive anterior drawer test	http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology		A test for ankle instability in which an anterior pull on the calcaneus with is applied with one hand while stabilizing the end of the tibia/fibula with the other hand. The test is considered positive (abnormal) if it results in more than one cm of anterior translation of the foot compared to the healthy, contralateral ankle.
http://purl.obolibrary.org/obo/HP_6001343	Peroneal tendon tear	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Injury to a peroneal tendon, as can be ascertained by an MRI study of the ankle showing partial or complete tear of one or both of the peroneal tendons.
http://purl.obolibrary.org/obo/HP_6001344	Fifth metatarsal apophysitis	http://purl.obolibrary.org/obo/HP_0008089	Abnormality of the fifth metatarsal bone		Iselin's disease is a traction apophysitis of base of fifth metatarsal. The apophysis is within the peroneus brevis tendon insertion site and appears radiographically at about age 10 in female and age 12 in male and usually fuses by age 11 in female and by age 14 in male. Repetitive microtrauma from the peroneus brevis tendon, as occurs in sports activities is the cause of traction apophysitis. It can be ascertained by oblique foot radiographs showing apophyseal irregularity (enlarged apophysis, disordered ossification, widened chondro-osseous junction) at the base of the fifth metatarsal.
http://purl.obolibrary.org/obo/HP_6001345	Tibial tubercle apophysitis	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		Lateral knee radiograph showing tibial tuberosity apophysis irregularity and fragmentation; tibial tubercle osteochondrosis; traction apophysitis of the tibial tubercle.
http://purl.obolibrary.org/obo/HP_6001346	Enteric anendocrinosis	http://purl.obolibrary.org/obo/HP_0002242	Abnormal intestine morphology		Near absence of small intestinal and colonic endocrine cells. This feature can be ascertained histopathologically and may also be manifested as a lack of staining for enteroendocrive markers such as synaptophysin.
http://purl.obolibrary.org/obo/HP_6001347	Metatarsal head osteochondrosis	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		Avascular necrosis of a metatarsal head, most commonly involving the second, but also the third or fourth, metatarsal.
Comment: Affected individuals may present with foot pain on weight-bearing, swelling, and tenderness. Radiological features include widening of the metatarsophalangeal joint space and flattening of the affected metatarsal head, at later stages metatarsal head sclerosis, cortical thickening, and intra-articular loose bodies. Osteochondrosis is a condition resulting from an epiphysis injury that alters enchondral ossification and produces irregularity at the joint surface. Freiberg disease is characterized as osteochondrosis of the metatarsal heads (primarily the second).
http://purl.obolibrary.org/obo/HP_6001348	Hallux sesamoiditis	http://purl.obolibrary.org/obo/HP_0001844	Abnormal hallux morphology		Inflammation of the sesamoid bones of the hallux ( two ovoid-shaped ossicles embedded within the tendons under the big toe). This feature can be ascertained by MRI of the foot, revealing edema within one or both of the hallux sesamoids.
http://purl.obolibrary.org/obo/HP_6001349	Os trigonum	http://purl.obolibrary.org/obo/HP_0008365	Abnormal talus morphology		Os trigonum (OT) is one of the most common accessory ossicles in the foot and ankle region. In clinical practice, OT is a considerable factor that may predispose patients to posterior ankle impingement syndrome (PAIS). Lateral ankle x-ray with foot in plantarflexion reveals an accessory ossicle at the posterior aspect of the talus, between the posterior distal tibia and calcaneal tuberosity.
http://purl.obolibrary.org/obo/HP_6001350	Positive heel squeeze test	http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology		The squeeze test is the most common examination for diagnosing calcaneal apophysitis (Sever disease) and is conducted by compressing the medial and lateral aspects of the calcaneus. The test is considered positive (abnormal) if squeezing elicits pain.
http://purl.obolibrary.org/obo/HP_6001351	Calcaneal apophysitis	http://purl.obolibrary.org/obo/HP_0008364	Abnormality of the calcaneus		Inflammation of the calcaneal apophysis (bony projection where the Achilles tendon attaches to the heel). Lateral foot x-ray shows increased density in the calcaneal apophysis or fragmentation of the apophysis.
http://purl.obolibrary.org/obo/HP_6001352	Decreased circulating guanidinoacetic acid concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		The concentration of guanidinoacetic acid in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6001353	Elevated circulating C-triol concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		The concentration of cholestane-3beta, 5alpha, 6beta-triol (C-triol) in the blood circulation is above the upper limit of normal. C-triol is a diagnostic biomarker for Niemann-Pick disease type C.
http://purl.obolibrary.org/obo/HP_6001354	Germinal vesicle oocyte maturation arrest	http://purl.obolibrary.org/obo/HP_0034914	Oocyte maturation arrest		A type of oocyte maturation arrest that occurs prior to the breakdown of the germinal vesicle (which is a hallmark of reinitiation of meiosis I and entry into M phase).
http://purl.obolibrary.org/obo/HP_6001355	Metaphase II oocyte maturation arrest	http://purl.obolibrary.org/obo/HP_0034914	Oocyte maturation arrest		The morphologic classification of MII generally denotes an oocyte that is mature, having arrested in metaphase II and is presumed to be capable of fertilization. However, there are subsets of women who produce oocytes with MII morphology that are not capable of embryo formation even with fertilization. This incongruence between morphologic maturity and capacity could be attributed to either the inclusion within the morphologic classification immature oocytes arrested at any stage between PBI formation and metaphase II, which are not capable of fertilization, or oocytes arrested normally at metaphase II that do not possess the ability to complete meiosis.
http://purl.obolibrary.org/obo/HP_6001356	Mixed oocyte maturation arrest	http://purl.obolibrary.org/obo/HP_0034914	Oocyte maturation arrest		A type of oocyte maturation failure whereby oocytes arrest at more than one stage of meiosis.
http://purl.obolibrary.org/obo/HP_6001357	Dorsal forearm pain	http://purl.obolibrary.org/obo/HP_6000299	Forearm pain		Pain localized to dorsal (non-palmar) aspect of the forearm.
http://purl.obolibrary.org/obo/HP_6001358	Volar forearm pain	http://purl.obolibrary.org/obo/HP_6000299	Forearm pain		Pain on the volar (palmar) aspect of the forearm.
http://purl.obolibrary.org/obo/HP_6001359	Cholesterol gallbladder polyp	http://purl.obolibrary.org/obo/HP_6001260	Gallbladder polyp		A non-neoplastic gallbladder polyp that is hyperplastic and consists of a lipid deposit. Cholesterol polyps are generally less than 10 mm. often multiple cholesterol polyps are present. They are often associated with vesicular cholesterolosis and are thought to have no malignant potential.
http://purl.obolibrary.org/obo/UBERON_8600148	tooth surface structure	http://purl.obolibrary.org/obo/UBERON_0003102	surface structure		A surface structure that is part of a calcareous tooth.
http://purl.obolibrary.org/obo/HP_0025199	Fragmented sleep	http://purl.obolibrary.org/obo/HP_4000064	Poor sleep		Sleep characterized by frequent interruptions, stopping and starting, which disrupt the normal progression of sleep stages.
http://purl.obolibrary.org/obo/HP_0025409	Abnormal spleen physiology	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the spleen		Any anomaly of the function of the spleen.
http://purl.obolibrary.org/obo/HP_0025429	Abnormal cry	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		Any anomaly of the vocalizing of an infant's crying, i.e.,the typically loud voice production that is accompanied by tears and agitation.
http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration	http://purl.obolibrary.org/obo/HP_0002921	Abnormal cerebrospinal fluid morphology		Any deviation from the normal range of a protein concentration in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0030972	Abnormal systemic blood pressure	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		A chronic deviation from normal pressure in the systemic arterial system.
http://purl.obolibrary.org/obo/HP_0030976	Abnormal factor VIII activity	http://purl.obolibrary.org/obo/HP_0010989	Abnormality of the intrinsic pathway		A deviation from the normal activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X.
http://purl.obolibrary.org/obo/HP_0031064	Impaired continence	http://purl.obolibrary.org/obo/HP_0031058	Impairment of activities of daily living		Partial or total incontinence of bowel or bladder.
http://purl.obolibrary.org/obo/HP_0031097	Abnormal circulating thyroid-stimulating hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0410031	Submucous cleft of soft and hard palate	http://purl.obolibrary.org/obo/HP_0410005	Cleft hard palate		Soft and hard-palate submucous clefts are characterized by bony defects in the midline of the soft and hard palate that are covered by the lining (ie mucous membrane) of the roof of the mouth.
http://purl.obolibrary.org/obo/HP_0500012	Abnormal gonadotropin-releasing hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		A deviation from the normal circulating concentration of the normal gonadotropin-releasing hormone (GnRH). Intermittent GnRH secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
http://purl.obolibrary.org/obo/HP_0500015	Abnormal cardiac test	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of the cardiovascular system		Abnormal test result of cardiovascular physiology.
http://purl.obolibrary.org/obo/HP_0031593	Abnormal PR interval	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		An anomaly of the PR interval, which is the portion of the ECG from the onset of the P wave to the beginning of the QRS complex. A normal PR interval in adults is 0.12-0.2 seconds.
http://purl.obolibrary.org/obo/HP_0031605	Abnormal fundus pigmentation	http://purl.obolibrary.org/obo/HP_0001098	Abnormal fundus morphology		Any anomaly of the pigmentation of the fundus, the posterior part of the eye including the retina and optic nerve. Fundus pigmentation should be evaluated in the context of skin and hair color.
http://purl.obolibrary.org/obo/GO_0110095	cellular detoxification of aldehyde	http://purl.obolibrary.org/obo/GO_1990748	cellular detoxification		Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
http://purl.obolibrary.org/obo/HP_0020058	Abnormal red blood cell count	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Any deviation from the normal number of red blood cells per volume in the circulation.
http://purl.obolibrary.org/obo/HP_0020059	Increased red blood cell count	http://purl.obolibrary.org/obo/HP_0020058	Abnormal red blood cell count		An abnormal elevation above the normal number of red blood cells per volume in the circulation.
http://purl.obolibrary.org/obo/HP_0020060	Decreased red blood cell count	http://purl.obolibrary.org/obo/HP_0020058	Abnormal red blood cell count		An abnormal reduction below the normal number of red blood cells per volume in the circulation.
http://purl.obolibrary.org/obo/HP_0020061	Abnormal hemoglobin concentration	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Any deviation from the normal concentration of hemoglobin in the blood.
http://purl.obolibrary.org/obo/HP_0020062	Decreased hemoglobin concentration	http://purl.obolibrary.org/obo/HP_0020061	Abnormal hemoglobin concentration		An abnormal reduction below normal hemoglobin concentration in the circulation.
http://purl.obolibrary.org/obo/HP_0032017	Sputum eosinophilia	http://purl.obolibrary.org/obo/HP_0032016	Abnormal sputum		An increased proportion of eosinophils in sputum in the differentiated cell count.
http://purl.obolibrary.org/obo/HP_0032018	Multiple mononeuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		A type of peripheral neuropathy that happens when there is damage to two or more different nerve areas characterized by peripheral neuropathy of both the motor and sensory nerves of at least two different nerve trunks. Different nerves are affected either simultaneously or sequentially.
http://purl.obolibrary.org/obo/HP_0032019	Muscle eosinophilia	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		Eosinophil infiltration of skeletal muscle.
http://purl.obolibrary.org/obo/HP_0032020	Eosinophilic bladder infiltration	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Transmural inflammation of the bladder predominantly with eosinophils, associated with fibrosis with or without muscle necrosis.
http://purl.obolibrary.org/obo/HP_0032021	Eosinophilic liver infiltration	http://purl.obolibrary.org/obo/HP_0032064	Gastrointestinal eosinophilia		Cellular infiltration of the liver parenchyma with a preponderance of eosinophils.
http://purl.obolibrary.org/obo/HP_0032022	Eosinophilic dermal infiltration	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Presence of abnormally increased amounts of intraepidermal inflammatory cells with a predominance of eosinophils.
http://purl.obolibrary.org/obo/HP_0032023	Eosinophilic gallbladder infiltration	http://purl.obolibrary.org/obo/HP_0032064	Gastrointestinal eosinophilia		Cellular infiltrate confirmed by a cellular infiltrate comprised of mainly eosinophils in the gallbladder wall on histological examination.
http://purl.obolibrary.org/obo/HP_0032024	Ileal ulcer	http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer		An erosion of the mucous membrane in a portion of the ileum.
http://purl.obolibrary.org/obo/HP_0032025	Decreased circulating alpha-1-antitrypsin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of alpha-1-antitrypsin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0032026	Anetoderma	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Circumscribed area of flaccid skin due to the loss of elastic tissue in the dermis.
http://purl.obolibrary.org/obo/HP_0032027	Retinal dots	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		Yellow, white or grayish lesions in the retina that are well-defined/distinct, individual and mostly uniform in size.
http://purl.obolibrary.org/obo/HP_0032028	Macular dots	http://purl.obolibrary.org/obo/HP_0030500	Yellow/white macular lesion		Yellow, white or grayish lesions in the macula that are well-defined/distinct, individual and mostly uniform in size.
http://purl.obolibrary.org/obo/HP_0032029	Floppy eyelid	http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity		Excessive eyelid tissue laxity, typically affecting both upper eyelids and associated with spontanteous tarsal eversion during sleep. It is more common in the obese, it may be associated with obstructive sleep apnea and it may result in corneal exposure or chronic papillary conjunctivitis.
http://purl.obolibrary.org/obo/HP_0032030	Lateral canthal tendon laxity	http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity		Laxity of the tendon stabilizing the lateral aspect of the tarsal plate to the zygomatic bone. This can result in rounded appearance of the lateral canthus. Also, when the eyelid is pulled medially, more than 2 mm movement of the canthal angle may be observed.
http://purl.obolibrary.org/obo/HP_0032031	Medial canthal tendon laxity	http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity		Laxity of the tendon stabilizing the medial aspect of the tarsal plate to the anterior and posterior lacrimal crests. This may lead to more than 2mm movement of the punctum when the eyelid is pulled laterally.
http://purl.obolibrary.org/obo/HP_0032032	Horizontal eyelid laxity	http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity		Abnormally lax eyelid associated with tissue relaxation, predominantly in the horizontal plane. It can be demonstrated by the horizontal eyelid distraction test (e.g. by pulling the eyelid medially and laterally). Medial and/or lateral canthal tendon laxity are often present.
http://purl.obolibrary.org/obo/HP_0032033	Vertical eyelid laxity	http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity		Abnormally lax eyelid associated with tissue relaxation, predominantly in the vertical plane. It can be demonstrated by vertical lid pull. Loosening of vertical stabilizing structures (e.g. lower lid retractors) or tarsal atrophy are often present.
http://purl.obolibrary.org/obo/HP_0032034	Upper eyelid laxity	http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity		Abnormally lax upper eyelid associated with tissue relaxation.
http://purl.obolibrary.org/obo/HP_0032035	Lower eyelid laxity	http://purl.obolibrary.org/obo/HP_0031880	Eyelid laxity		Abnormally lax lower eyelid associated with tissue relaxation.
http://purl.obolibrary.org/obo/HP_0032036	Reduced contrast sensitivity	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		An abnormality in perception of contrast. Spatial contrast is a physical dimension referring to the light-dark transition of a border or an edge in an image that delineates the existence of a pattern or an object. Contrast sensitivity refers to a measure of how much contrast a person requires to see a target. Contrast-sensitivity measurements differ from acuity measurements; acuity is a measure of the spatial-resolving ability of the visual system under conditions of very high contrast, whereas contrast sensitivity is a measure of the threshold contrast for seeing a target.
http://purl.obolibrary.org/obo/HP_0032037	Mildly reduced visual acuity	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		Mild reduction of the ability to see. On the 6m visual acuity scale, mild reduction is defined as less than 6/12 but at least 6/18. On the 20ft visual acuity scale, mild reduction is defined as less than 20/40 but at least 20/70. On the decimal visual acuity scale, mild reduction is defined as less than 0.5 but at least 0.3.
http://purl.obolibrary.org/obo/HP_0032039	Abnormality of the ocular adnexa	http://purl.obolibrary.org/obo/HP_0000315	Abnormality of the orbital region		An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.
http://purl.obolibrary.org/obo/HP_0032040	Abnormal ocular adnexa physiology	http://purl.obolibrary.org/obo/HP_0032039	Abnormality of the ocular adnexa		A functional anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.
http://purl.obolibrary.org/obo/HP_0032041	Vocal cord polyp	http://purl.obolibrary.org/obo/HP_0008777	Abnormal vocal cord morphology		A small growth on a vocal cord that may appear as pedunculated or sessile and have varying size, shape, and color.
http://purl.obolibrary.org/obo/HP_0032043	Odynophagia	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		Pain experienced with swallowing.
http://purl.obolibrary.org/obo/HP_0032044	Decreased vigilance	http://purl.obolibrary.org/obo/HP_0004372	Reduced consciousness		A decrease in the ability to maintain sustained attention is characterized by reduced alertness.
http://purl.obolibrary.org/obo/HP_0032045	Hypoplastic carotid canal	http://purl.obolibrary.org/obo/HP_0009911	Abnormal temporal bone morphology		Underdevelopment of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse.
http://purl.obolibrary.org/obo/HP_0032046	Focal cortical dysplasia	http://purl.obolibrary.org/obo/HP_0002539	Cortical dysplasia		A type of malformation of cortical development that primarily affects areas of neocortex. It can be identified on conventional magnetic resonance imaging as focal cortical thickening, abnormal gyration, and blurring between gray and white matter, often associated with clusters of heterotopic neurons.
http://purl.obolibrary.org/obo/HP_0032047	Focal cortical dysplasia type I	http://purl.obolibrary.org/obo/HP_0032046	Focal cortical dysplasia		A type of focal cortical dysplasia that is characterized by abnormal cortical layering.
http://purl.obolibrary.org/obo/HP_0032048	Focal cortical dysplasia type Ia	http://purl.obolibrary.org/obo/HP_0032047	Focal cortical dysplasia type I		A subtype of focal cortical dysplasia type I that is characterized by abnormal radial cortical lamination.
http://purl.obolibrary.org/obo/HP_0032049	Focal cortical dysplasia type Ib	http://purl.obolibrary.org/obo/HP_0032047	Focal cortical dysplasia type I		A subtype of focal cortical dysplasia type I that is characterized by abnormal tangential cortical lamination.
http://purl.obolibrary.org/obo/HP_0032050	Focal cortical dysplasia type Ic	http://purl.obolibrary.org/obo/HP_0032049	Focal cortical dysplasia type Ib		A subtype of focal cortical dysplasia type I that is characterized by abnormal radial and tangential cortical lamination.
http://purl.obolibrary.org/obo/HP_0032051	Focal cortical dysplasia type II	http://purl.obolibrary.org/obo/HP_0032046	Focal cortical dysplasia		A type of focal cortical dysplasia that is characterized by disrupted cortical lamination and specific cytological abnormalities.
http://purl.obolibrary.org/obo/HP_0032052	Focal cortical dysplasia type IIa	http://purl.obolibrary.org/obo/HP_0032051	Focal cortical dysplasia type II		A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons, which present with a significantly enlarged cell body and nucleus, malorientation, abnormally distributed intracellular Nissl substance and cytoplasmic accumulation of neurofilament proteins.
http://purl.obolibrary.org/obo/HP_0032053	Focal cortical dysplasia type IIb	http://purl.obolibrary.org/obo/HP_0032051	Focal cortical dysplasia type II		A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons (significantly enlarged with accumulation of neurofilament proteins) and balloon cells.
http://purl.obolibrary.org/obo/HP_0032054	Focal cortical dysplasia type III	http://purl.obolibrary.org/obo/HP_0032046	Focal cortical dysplasia		A type of focal cortical dysplasia that is characterized by cortical lamination abnormalities associated with a principal lesion, usually adjacent to or affecting the same cortical area/lobe.
http://purl.obolibrary.org/obo/HP_0032055	Focal cortical dysplasia type IIIa	http://purl.obolibrary.org/obo/HP_0032054	Focal cortical dysplasia type III		A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural organization (cortical dyslamination) or cytoarchitectural composition (hypertrophic neurons outside Layer 5) in patients with hippocampal sclerosis (also known as Ammon's horn sclerosis).
http://purl.obolibrary.org/obo/HP_0032056	Focal cortical dysplasia type IIIb	http://purl.obolibrary.org/obo/HP_0032054	Focal cortical dysplasia type III		A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) and/or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to glial or glioneuronal tumor.
http://purl.obolibrary.org/obo/HP_0032057	Focal cortical dysplasia type IIIc	http://purl.obolibrary.org/obo/HP_0032054	Focal cortical dysplasia type III		A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural (cortical dyslamination, hypoplasia) or cytoarchitectural composition of the neocortex (hypertrophic neurons), which occur adjacent to vascular malformations (cavernomas, arteriovenous malformations, leptomeningeal vascular malformations, telangiectasias, meningioangiomatosis).
http://purl.obolibrary.org/obo/HP_0032058	Focal cortical dysplasia type IIId	http://purl.obolibrary.org/obo/HP_0032054	Focal cortical dysplasia type III		A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to other lesions acquired during early life (not included into FCD Type IIIa-c). These lesions comprise a large spectrum including traumatic brain injury, glial scarring after prenatal or perinatal ischemic injury or bleeding, and inflammatory or infectious diseases, i.e. Rasmussen encephalitis, limbic encephalitis, bacterial or viral infections.
http://purl.obolibrary.org/obo/HP_0032059	Mild malformation of cortical development	http://purl.obolibrary.org/obo/HP_0002539	Cortical dysplasia		A malformation of cortical development characterized by mild abnormalities of the cortex: excessive heterotopic neurons in Layer 1 or microscopic neuronal clusters or excess of single neurons of normal morphology in deep white matter.
http://purl.obolibrary.org/obo/HP_0032060	Epithelioid hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area.
http://purl.obolibrary.org/obo/HP_0032061	Severely increased total eosinophil count	http://purl.obolibrary.org/obo/HP_0001880	Increased total eosinophil count		Severe increase in circulating eosinophils, usually characterized as more than 1500 eosinophils per microlitre.
http://purl.obolibrary.org/obo/HP_0032062	Mallory-Weiss tear	http://purl.obolibrary.org/obo/HP_0002031	Abnormal esophagus morphology		Vomiting-induced mucosal laceration at the esophago-gastric junction.
http://purl.obolibrary.org/obo/HP_0032063	Ankle joint effusion	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		Abnormal accumulation of fluid in or around the ankle joint.
http://purl.obolibrary.org/obo/HP_0032064	Gastrointestinal eosinophilia	http://purl.obolibrary.org/obo/HP_0012718	Abnormal gastrointestinal tract morphology		Eosinophilic infiltration of one or more gastrointestinal organs. Gastrointestinal eosinophilia is a broad term for abnormal eosinophil accumulation in the GI tract, involving many different disease identities. These diseases include primary eosinophil associated gastrointestinal diseases, gastrointestinal eosinophilia in HES and all gastrointestinal eosinophilic states associated with known causes. Each of these diseases has its unique features but there is no absolute boundary between them.
http://purl.obolibrary.org/obo/HP_0032065	Abnormal circulating bicarbonate concentration	http://purl.obolibrary.org/obo/HP_0020330	Abnormal circulating inorganic anion concentration		Any deviation from the normal concentration of bicarbonate, HCO3[-], in the circulation.
http://purl.obolibrary.org/obo/HP_0032066	Decreased serum bicarbonate concentration	http://purl.obolibrary.org/obo/HP_0032065	Abnormal circulating bicarbonate concentration		An abnormal reduction of the concentration of bicarbonate, HCO3[-], in the circulation.
http://purl.obolibrary.org/obo/HP_0032067	Elevated serum bicarbonate concentration	http://purl.obolibrary.org/obo/HP_0032065	Abnormal circulating bicarbonate concentration		An abnormal increase in the concentration of bicarbonate, HCO3[-], in the circulation.
http://purl.obolibrary.org/obo/HP_0032068	Increased urinary mucus	http://purl.obolibrary.org/obo/HP_0033072	Abnormal macroscopic urine appearance		An increased amount of urinary mucus. A small amount of mucus is produced by mucous membrane epithelial cells of the urinary tract. An increased amount of mucus can be detected upon urinalysis or other assays and may indicate conditions such as urinary tract infection, urinary tract reconstruction involving the use of bowel segments, or contamination of the urine sample prior to urinalysis.
http://purl.obolibrary.org/obo/HP_0032069	Anti-thyroglobulin antibody positivity	http://purl.obolibrary.org/obo/HP_0430050	Anti-thyroid antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react to thyroglobulin.
http://purl.obolibrary.org/obo/HP_0032070	Leptomeningeal enhancement	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		Contrast material enhancement of the pia mater or enhancement that extends into the subarachnoid spaces of the sulci and cisterns is leptomeningeal enhancement. Leptomeningeal enhancement is usually associated with meningitis, which may be bacterial, viral, or fungal. The primary mechanism of this enhancement is breakdown of the blood-brain barrier without angiogenesis.
http://purl.obolibrary.org/obo/HP_0032071	Eosinophilic pneumonia	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia.
http://purl.obolibrary.org/obo/HP_0040334	Purulent rhinitis	http://purl.obolibrary.org/obo/HP_0002257	Chronic rhinitis		Chronic rhinitis accompanied by pus formation.
http://purl.obolibrary.org/obo/HP_0410204	Increased intestinal transit time	http://purl.obolibrary.org/obo/HP_0030896	Abnormal gastrointestinal transit time		An increase in the length of time required for food to pass through the intestines.
http://purl.obolibrary.org/obo/HP_0410205	Abnormal circulating nicotinurate concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		Any deviation from the normal concentration of nicotinurate in the blood.
http://purl.obolibrary.org/obo/HP_0410206	Increased circulating nicotinurate level	http://purl.obolibrary.org/obo/HP_0410205	Abnormal circulating nicotinurate concentration		An increased amount of nicotinurate in the blood.
http://purl.obolibrary.org/obo/HP_0410207	Positive methadone plasma/serum test	http://purl.obolibrary.org/obo/HP_0500100	Plasma/serum xenobiotic		Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in plasma or serum.
http://purl.obolibrary.org/obo/HP_0410208	Positive plasma/serum cotinine test	http://purl.obolibrary.org/obo/HP_0500100	Plasma/serum xenobiotic		Detection of cotinine, an alkaloid found in tobacco and the predominant metabolite of nicotine, in plasma or serum.
http://purl.obolibrary.org/obo/HP_0410209	Folate deficiency in CSF	http://purl.obolibrary.org/obo/HP_0020351	Abnormal CSF folate concentration		A reduced concentration of folic acid, which is also known as vitamin B9 in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0410210	Abnormal cord blood measurement	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		An abnormality in any umbilical cord measurement performed after birth, such as the blood gas level.
http://purl.obolibrary.org/obo/HP_0410212	Hyperoxemia in cord blood	http://purl.obolibrary.org/obo/HP_0500259	Abnormal oxygen level in cord blood		An abnormally high level of blood oxygen in the cord blood.
http://purl.obolibrary.org/obo/HP_0410213	Hypoxemia in cord blood	http://purl.obolibrary.org/obo/HP_0500259	Abnormal oxygen level in cord blood		An abnormally low level of blood oxygen in the cord blood.
http://purl.obolibrary.org/obo/HP_0410214	Hypercapnia in cord blood	http://purl.obolibrary.org/obo/HP_0500258	Abnormal carbon dioxide level in cord blood		Abnormally elevated blood carbon dioxide (CO2) level in the cord blood.
http://purl.obolibrary.org/obo/HP_0410215	Hypocapnia in cord blood	http://purl.obolibrary.org/obo/HP_0500258	Abnormal carbon dioxide level in cord blood		Abnormally decreased blood carbon dioxide (CO2) level in the cord blood.
http://purl.obolibrary.org/obo/HP_0410216	Abnormal circulating 5-methyltetrahydrofolate concentration	http://purl.obolibrary.org/obo/HP_0040087	Abnormal circulating folate concentration		An abnormal concentration of 5-methyltetrahydrofolate (5-MTHF) in the blood.
http://purl.obolibrary.org/obo/HP_0410217	Reduced blood 5-methyltetrahydrofolate level	http://purl.obolibrary.org/obo/HP_0410216	Abnormal circulating 5-methyltetrahydrofolate concentration		A decreased concentration of 5-methyltetrahydrofolate in the blood.
http://purl.obolibrary.org/obo/HP_0410218	Hypoplasia of maxilla relative to mandible	http://purl.obolibrary.org/obo/HP_0000327	Hypoplasia of the maxilla		Abnormally small dimension of the maxilla (upper jaw) relative to the mandible (lower jaw).
http://purl.obolibrary.org/obo/HP_0410219	Hypoplasia of mandible relative to maxilla	http://purl.obolibrary.org/obo/HP_0000347	Micrognathia		Abnormally small dimension of the mandible (lower jaw) relative to the maxilla (upper jaw).
http://purl.obolibrary.org/obo/HP_0410220	Increased anti-dairy protein IgE antibody level	http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level		Increased level of IgE antibody against dairy proteins, including casein, alpha-lactalbumin, beta-lactoglobulin or bovine serum albumin contained in cow, sheep or goat milk and milk products.
http://purl.obolibrary.org/obo/HP_0410221	Increased anti-animal protein IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against animal proteins, such as albumins that are present in animal hair, dander, shed skin, saliva and urine.
http://purl.obolibrary.org/obo/HP_0410222	Increased anti-seafood IgE antibody level	http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level		Increased level of IgE antibody against seafood, including fish, shrimp, lobster, crab, squid and abalone.
http://purl.obolibrary.org/obo/HP_0410223	Increased anti-dust mite IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against dust mites, such as house dust mites.
http://purl.obolibrary.org/obo/HP_0410224	Increased anti-bacteria IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against bacteria.
http://purl.obolibrary.org/obo/HP_0410225	Increased anti-drug IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against a drug or class of drugs, such as antibiotics.
http://purl.obolibrary.org/obo/HP_0410226	Increased anti-feather IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against feathers, which could be indicative of an allergy against feathers themselves, or mite allergens present in feathers.
http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against proteins found in foods, such as milk, egg, soy, wheat, peanut, treenut, fish, and shellfish.
http://purl.obolibrary.org/obo/HP_0410228	Increased anti-plant based food allergen IgE antibody level	http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level		Increased level of IgE antibody against a plant based food allergen, including vegetables and fruits.
http://purl.obolibrary.org/obo/HP_0410229	Increased anti-gluten IgE antibody level	http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level		Increased level of IgE antibody against gluten, a protein found in wheat, barley, and rye.
http://purl.obolibrary.org/obo/HP_0410230	Increased anti-nut food product IgE antibody level	http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level		Increased level of IgE antibody against nut food products such as peanuts or tree nuts, such as hazelnuts, walnuts, cashews, and almonds.
http://purl.obolibrary.org/obo/HP_0410231	Increased anti-egg IgE antibody level	http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level		Increased level of IgE antibody against eggs, including egg whites, egg yolks, and egg proteins such as ovoalbumin and ovomucoid.
http://purl.obolibrary.org/obo/HP_0410232	Increased anti-fungi IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against fungus, such as molds like zygomycota, ascomycota and deuteromycota.
http://purl.obolibrary.org/obo/HP_0410233	Increased anti-meat allergen IgE antibody level	http://purl.obolibrary.org/obo/HP_0410227	Increased anti-food allergen IgE antibody level		Increased level of IgE antibody against meat, such as mammalian meat, including beef or pork, or poultry, like duck or chicken.
http://purl.obolibrary.org/obo/HP_0410234	Increased anti-parasite IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against parasites, such as helminths (parasitic worms, such as Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenalis, Necator americanus, Strongyloides stercoralis) or parasites such as Toxoplasma gondii.
http://purl.obolibrary.org/obo/HP_0410235	Increased anti-insect IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against antigens from insects such as moths, mosquitos, or cockroaches.
http://purl.obolibrary.org/obo/HP_0410236	Increased anti-venom IgE antibody level	http://purl.obolibrary.org/obo/HP_0410235	Increased anti-insect IgE antibody level		Increased level of IgE antibody against venom from insects such as bees, wasps, hornets, yellowjackets.
http://purl.obolibrary.org/obo/HP_0410238	Increased anti-plant product IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against antigens from plants and products derived from plants, such as wood or pollen.
http://purl.obolibrary.org/obo/HP_0500132	Hypovalinemia	http://purl.obolibrary.org/obo/HP_0010914	Abnormal circulating valine concentration		The concentration of valine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500133	Hypotyrosinemia	http://purl.obolibrary.org/obo/HP_0010917	Abnormal circulating tyrosine concentration		An decreased concentration of tyrosine in the blood.
http://purl.obolibrary.org/obo/HP_0500134	Hypertryptophanemia	http://purl.obolibrary.org/obo/HP_0004365	Abnormal circulating tryptophan concentration		The concentration of tryptophan in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0500135	Hypotryptophanemia	http://purl.obolibrary.org/obo/HP_0004365	Abnormal circulating tryptophan concentration		The concentration of tryptophan in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500136	Hypothreoninemia	http://purl.obolibrary.org/obo/HP_0010900	Abnormal circulating threonine concentration		The concentration of threonine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500138	Hyperserinemia	http://purl.obolibrary.org/obo/HP_0012278	Abnormal circulating serine concentration		An increased amount of serine in the blood.
http://purl.obolibrary.org/obo/HP_0500139	Hypoprolinemia	http://purl.obolibrary.org/obo/HP_0010907	Abnormal circulating proline concentration		The concentration of proline in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500140	Decreased circulating hydroxyproline concentration	http://purl.obolibrary.org/obo/HP_0010907	Abnormal circulating proline concentration		A decreased amount of hydroxyproline in the blood.
http://purl.obolibrary.org/obo/HP_0500141	Hypophenylalaninemia	http://purl.obolibrary.org/obo/HP_0010893	Abnormal circulating phenylalanine concentration		The concentration of phenylalanine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500142	Hypolysinemia	http://purl.obolibrary.org/obo/HP_0010908	Abnormal circulating lysine concentration		The concentration of lysine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500143	Hypoleucinemia	http://purl.obolibrary.org/obo/HP_0004357	Abnormal circulating leucine concentration		The concentration of leucine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500144	Hypoisoleucinemia	http://purl.obolibrary.org/obo/HP_0010912	Abnormal circulating isoleucine concentration		The concentration of isoleucine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500145	Hypohistidinemia	http://purl.obolibrary.org/obo/HP_0010904	Abnormal circulating histidine concentration		The concentration of histidine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500147	Hypoglutaminemia	http://purl.obolibrary.org/obo/HP_0010903	Abnormal circulating glutamine concentration		The concentration of glutamine in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0500148	Abnormal circulating glutamate concentration	http://purl.obolibrary.org/obo/HP_0010902	Abnormal circulating glutamine family amino acid concentration		Any deviation from the normal concentration of glutamate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0500149	Hyperglutamatemia	http://purl.obolibrary.org/obo/HP_0500148	Abnormal circulating glutamate concentration		Concentration of glutamate in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0500150	Hypoglutamatemia	http://purl.obolibrary.org/obo/HP_0500148	Abnormal circulating glutamate concentration		A decreased amount of glutamate in the blood.
http://purl.obolibrary.org/obo/HP_0500151	Hypercystinemia	http://purl.obolibrary.org/obo/HP_0010918	Abnormal circulating cysteine concentration		An increased amount of cystine in the blood.
http://purl.obolibrary.org/obo/HP_0500152	Hypocystinemia	http://purl.obolibrary.org/obo/HP_0010918	Abnormal circulating cysteine concentration		A decreased amount of cystine in the blood.
http://purl.obolibrary.org/obo/HP_0500153	Hyperargininemia	http://purl.obolibrary.org/obo/HP_0010909	Abnormal circulating arginine concentration		An increased amount of arginine levels in the blood.
http://purl.obolibrary.org/obo/HP_0500154	Hypoalaninemia	http://purl.obolibrary.org/obo/HP_0010916	Abnormal circulating alanine concentration		A decreased amount of alanine in the blood.
http://purl.obolibrary.org/obo/HP_0500155	Abnormal circulating asparagine concentration	http://purl.obolibrary.org/obo/HP_0010899	Abnormal circulating aspartate family amino acid concentration		Any deviation from the normal concentration of asparagine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0500156	Hyperasparaginemia	http://purl.obolibrary.org/obo/HP_0500155	Abnormal circulating asparagine concentration		An increased amount of asparagine in the blood.
http://purl.obolibrary.org/obo/HP_0500157	Hypoasparaginemia	http://purl.obolibrary.org/obo/HP_0500155	Abnormal circulating asparagine concentration		A decreased amount of asparagine in the blood.
http://purl.obolibrary.org/obo/HP_0500158	Abnormal circulating aspartic acid concentration	http://purl.obolibrary.org/obo/HP_0010899	Abnormal circulating aspartate family amino acid concentration		Any deviation from the normal concentration of aspartate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0500159	Increased circulating aspartic acid concentration	http://purl.obolibrary.org/obo/HP_0500158	Abnormal circulating aspartic acid concentration		An increased concentration of aspartic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0500160	Abnormal circulating carnosine concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		Any deviation from the normal concentration of carnosine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0500161	Increased circulating carnosine concentration	http://purl.obolibrary.org/obo/HP_0500160	Abnormal circulating carnosine concentration		Concentration of carnosine in the blood circulation above normal limits.
http://purl.obolibrary.org/obo/HP_0500162	Decreased circulating carnosine concentration	http://purl.obolibrary.org/obo/HP_0500160	Abnormal circulating carnosine concentration		A decreased amount of carnosine in blood.
http://purl.obolibrary.org/obo/HP_0410239	Positive urine norcotinine test	http://purl.obolibrary.org/obo/HP_0031840	Urine xenobiotic		Detection of norcotinine, a metabolite of nicotine, in urine.
http://purl.obolibrary.org/obo/HP_0410243	Abnormal circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		An abnormal deviation from normal levels of IgM immunoglobulin in blood.
http://purl.obolibrary.org/obo/HP_0410244	Abnormal circulating IgD concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		An abnormal deviation from normal levels of IgD immunoglobulin in blood.
http://purl.obolibrary.org/obo/HP_0410245	Decreased circulating IgD concentration	http://purl.obolibrary.org/obo/HP_0410244	Abnormal circulating IgD concentration		An abnormally decreased level of immunoglobulin D (IgD) in blood.
http://purl.obolibrary.org/obo/HP_0410246	Increased circulating IgD concentration	http://purl.obolibrary.org/obo/HP_0410244	Abnormal circulating IgD concentration		An abnormally increased level of immunoglobulin D in blood.
http://purl.obolibrary.org/obo/HP_0410247	Increased anti-animal dander IgE antibody level	http://purl.obolibrary.org/obo/HP_0410221	Increased anti-animal protein IgE antibody level		Increased level of IgE antibody against animal dander, tiny scales shed from animal skin or hair, such as from pet dogs or cats.
http://purl.obolibrary.org/obo/HP_0410248	Increased anti-house dust mite IgE antibody level	http://purl.obolibrary.org/obo/HP_0410223	Increased anti-dust mite IgE antibody level		Increased level of IgE antibody against house dust mites, a common allergen.
http://purl.obolibrary.org/obo/HP_0410249	Increased anti-alpha-gal IgE antibody level	http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration		Increased level of IgE antibody against galactose-alpha-1, 3 galactose (alpha-gal), a carbohydrate found in mammalian meat.
http://purl.obolibrary.org/obo/HP_0410251	Decreased neutrophil toll-like receptor signalling	http://purl.obolibrary.org/obo/HP_0011990	Abnormal neutrophil physiology		Abnormal decrease of neutrophil activation following toll-like receptor (TLR) ligation, commonly measured by evaluation of CD62L shedding after stimulation with lipopolysaccharide (LPS) using flow cytometry.
http://purl.obolibrary.org/obo/HP_0410252	Persistently decreased total neutrophil count	http://purl.obolibrary.org/obo/HP_0001875	Decreased total neutrophil count		Abnormal decrease of the absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group, which persists for 3 or more months.
http://purl.obolibrary.org/obo/HP_0410253	Myeloid maturation arrest	http://purl.obolibrary.org/obo/HP_0033606	Bone marrow maturation arrest		Chornic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0410254	Cyclic neutropenia in myeloid maturation arrest in bone marrow	http://purl.obolibrary.org/obo/HP_0040289	Cyclically decreased total neutrophil count		Cyclic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0410255	Transiently decreased total neutrophil count	http://purl.obolibrary.org/obo/HP_0001875	Decreased total neutrophil count		Abnormal decrease of the absolute number of neutrophils in the blood, per microlitre, compared to a reference range for a given sex and age-group, which persists for less than 3 months and then spontaneously recovers, but does not recur cyclically.
http://purl.obolibrary.org/obo/HP_0410256	Infection associated neutropenia	http://purl.obolibrary.org/obo/HP_0410255	Transiently decreased total neutrophil count		Transient neutropenia caused by an infection, such as with a virus, bacteria or protozoan.
http://purl.obolibrary.org/obo/HP_0410257	Neutrophilia in presence of infection	http://purl.obolibrary.org/obo/HP_0011897	Increased total neutrophil count		An increased number of neutrophils circulating in the blood during an infection, such as with a bacteria, virus or fungus.
http://purl.obolibrary.org/obo/HP_0410258	Neutrophilia in absence of infection	http://purl.obolibrary.org/obo/HP_0011897	Increased total neutrophil count		An increased number of neutrophils circulating in the blood in the absence of an infection. Factors contributing to neutrophilia could include inflammation or congenital disorders.
http://purl.obolibrary.org/obo/HP_0410259	Hepatopulmonary fusion	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Fusion of the liver with the lung.
http://purl.obolibrary.org/obo/HP_0410260	Asymmetrical gluteal crease	http://purl.obolibrary.org/obo/HP_0001437	Abnormality of the musculature of the lower limbs		The presence of an asymmetrical gluteal crease, the horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg.
http://purl.obolibrary.org/obo/HP_0410261	Wide space between 4th and 5th toe	http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology		A widely spaced gap between the fourth toe and the fifth (pinky) toe.
http://purl.obolibrary.org/obo/HP_0410262	Lower cranial nerve dysfunction	http://purl.obolibrary.org/obo/HP_0031910	Abnormal cranial nerve physiology		A functional abnormality affecting the lower cranial nerves, which include the paired 9th (glossopharyngeal), 10th (vagal), 11th (accessory) and 12th (hypoglossal) cranial nerves.
http://purl.obolibrary.org/obo/HP_0410264	Subglottic hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, located in the airway, typically below the vocal chords, that can cause severe obstruction of the airway.
http://purl.obolibrary.org/obo/HP_0410265	Supraglottic hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, located in the upper part of the larynx (voice box) including the epiglottis; the area above the vocal cords.
http://purl.obolibrary.org/obo/HP_0410267	Intestinal hemangioma	http://purl.obolibrary.org/obo/HP_0410266	Visceral hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, located in the intestines, which includes the bowel.
http://purl.obolibrary.org/obo/HP_0410268	Spleen hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the spleen.
http://purl.obolibrary.org/obo/HP_0410269	Labial hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the upper lip.
http://purl.obolibrary.org/obo/HP_0410270	Esophageal hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the esophagus.
http://purl.obolibrary.org/obo/HP_0410271	Laryngeal hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the glottic or supraglottic regions.
http://purl.obolibrary.org/obo/HP_0410272	Vulvar hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the vulva.
http://purl.obolibrary.org/obo/HP_0410273	Retropharyngeal hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the retropharyngeal space, the portion of the peripharyngeal space that is located posterior to the pharynx.
http://purl.obolibrary.org/obo/HP_0410274	Paraspinal hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the paraspinal muscular region, the muscles next to the spine.
http://purl.obolibrary.org/obo/HP_0410275	Lumbosacral hemangioma	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		A spinal cord hemangioma located in the lumbosacral spine region.
http://purl.obolibrary.org/obo/HP_0410276	Supraumbilical raphe	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		An abnormality of the sternum that presents at birth as a ventral sternal non-union defect, due to an abnormality of the fusion of the layers of the skin. It presents as a scar-like line that extends upward from the umbilicus (belly button).
http://purl.obolibrary.org/obo/HP_0410277	Sternal pit	http://purl.obolibrary.org/obo/HP_0000766	Abnormal sternum morphology		A sternal pit is a small indentation or dimple in the skin overlying the sternum of the chest. In some cases, the skin defect can be linear, extending several inches over the sternum.
http://purl.obolibrary.org/obo/HP_0410278	Pituitary gland cyst	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		A fluid-filled sacs that develop on or near the pituitary gland.
http://purl.obolibrary.org/obo/HP_0410279	Atrophic pituitary gland	http://purl.obolibrary.org/obo/HP_0012506	Small pituitary gland		Partial or complete wasting (loss) of the pituitary gland.
http://purl.obolibrary.org/obo/HP_0410281	Dyspepsia	http://purl.obolibrary.org/obo/HP_0002027	Abdominal pain		A heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness, early satiation, epigastric pain and epigastric burning, but other upper gastrointestinal symptoms such as nausea, belching or abdominal bloating often occur.
http://purl.obolibrary.org/obo/HP_0410282	Abnormal circulating amylase concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of amylase in the blood circulation.
http://purl.obolibrary.org/obo/HP_0410283	Positive blood acetaminophen test	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Detection of acetaminophen in the blood.
http://purl.obolibrary.org/obo/HP_0410284	Positive norpropoxyphene blood test	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Detection of norpropoxyphene in the blood, a major metabolite of the opioid analgesic drug dextropropoxyphene.
http://purl.obolibrary.org/obo/HP_0410285	Positive meconium methadone test	http://purl.obolibrary.org/obo/HP_0500098	Meconium xenobiotic		Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in meconium.
http://purl.obolibrary.org/obo/HP_0410286	Positive blood molindone test	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Detection of molindone in the blood, an antipyschotic used for treatment of schizophrenia.
http://purl.obolibrary.org/obo/HP_0500163	Hypoornithinemia	http://purl.obolibrary.org/obo/HP_0012025	Abnormal circulating ornithine concentration		An abnormal decrease in ornithine in the blood.
http://purl.obolibrary.org/obo/HP_0500166	Abnormal circulating gastrin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		An abnormal concentration of gastrin in the blood.
http://purl.obolibrary.org/obo/HP_0500167	Hypergastrinemia	http://purl.obolibrary.org/obo/HP_0500166	Abnormal circulating gastrin concentration		An elevated amount of gastrin in the blood.
http://purl.obolibrary.org/obo/HP_0500170	Abnormal concentration of acylcarnitine in the urine	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An abnormal amount of acylcarnitine in the urine.
http://purl.obolibrary.org/obo/HP_0500173	Reflex asystolic syncope	http://purl.obolibrary.org/obo/HP_0001279	Syncope		A loss of consciousness followed by stiffening and brief clonic movements affecting some or all limbs, often misinterpreted as an epileptic seizure.
http://purl.obolibrary.org/obo/UBERON_0036295	renal pelvis/ureter	http://purl.obolibrary.org/obo/UBERON_0000477	anatomical cluster		The upper tract of the renal system. The renal pelvis is the large cavity in the middle of each kidney. Urine drains from each kidney through a long tube called the ureter, into the bladder, where it is stored until it is passed from the body through the urethra.
http://purl.obolibrary.org/obo/HP_0032367	Abnormal circulating growth hormone concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal level of growth hormone (GH) in the blood circulation. GH or somatotropin is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration. Its secretion from the pituitary is regulated by the neurosecretory nuclei of the hypothalamus, which can release Growth hormone-releasing hormone (GHRH or somatocrinin) and Growth hormone-inhibiting hormone (GHIH or somatostatin) into the hypophyseal portal venous blood surrounding the pituitary. GH is secreted in a pulsatile manner, which is one of the reasons why an isolated measurement of its blood concentration is not meaningful.
http://purl.obolibrary.org/obo/HP_0020075	Leucine crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		The presence of leucine crystals in the urine.
http://purl.obolibrary.org/obo/HP_0020076	Wrist ganglion	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		A benign soft tissue tumor of the wrist usually found in the dorsal aspect of the wrist and communicate with the joint via a pedicle. This pedicle usually originates not only at the scapholunate ligament, but also may arise from a number of other sites over the dorsal aspect of the wrist capsule.
http://purl.obolibrary.org/obo/HP_0020077	Carnitinuria	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		An elevated level of carnitine in the urine.
http://purl.obolibrary.org/obo/HP_0020078	Alaninuria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An increased level of alanine in the urine.
http://purl.obolibrary.org/obo/HP_0020079	Beta-alaninuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of beta-alanine in the urine, when normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0020080	Erythrocyte inclusion bodies	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		Nuclear or cytoplasmic aggregates of substances in red blood cells.
http://purl.obolibrary.org/obo/HP_0020081	Pappenheimer bodies	http://purl.obolibrary.org/obo/HP_0020080	Erythrocyte inclusion bodies		A type of erythrocyte inclusion characterized by basophilic stippling of erythrocytes, that is, by numerous very small coarse or fine blue granules within the cytoplasm with the additional stipulation that the stippled particles are due to iron granules (demonstrable by the Prussian blue stain).
http://purl.obolibrary.org/obo/HP_0020082	Heinz bodies	http://purl.obolibrary.org/obo/HP_0020080	Erythrocyte inclusion bodies		A type of erythrocyte inclusion composed of denatured hemoglobin.
http://purl.obolibrary.org/obo/HP_0020083	Furuncle	http://purl.obolibrary.org/obo/HP_0025084	Folliculitis		An infection of a hair follicle that extends subcutaneously, forming an abscess.
http://purl.obolibrary.org/obo/HP_0020084	Carbuncle	http://purl.obolibrary.org/obo/HP_0025084	Folliculitis		A pustular lesion of the skin emerging from group of infected hair follicles, characterized by a deep location and dissecting through tissue planes. A carbuncle is larger and deeper than a furuncle.
http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		An infection resulting from live attenuated vaccines (LAV), that is, a vaccine prepared from living viruses or bacteria that have been weakened under laboratory conditions. LAV vaccines will replicate in a vaccinated individual and produce an immune response but usually cause mild or no disease. are derived from disease-causing pathogens.
http://purl.obolibrary.org/obo/HP_0020086	BCGitis	http://purl.obolibrary.org/obo/HP_5210408	BCG-associated disease		Local or regional infection with Bacillus Calmette-Guerin (BCG) following vaccination.
http://purl.obolibrary.org/obo/HP_0020087	BCGosis	http://purl.obolibrary.org/obo/HP_5210408	BCG-associated disease		Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.
http://purl.obolibrary.org/obo/HP_0020088	Post-vaccination measles	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		Infection with the measles virus of the live-attenuated vaccine. This is an extremely rare event and may indicate immunocompromise in some cases.
http://purl.obolibrary.org/obo/HP_0020089	Post-vaccination rubella	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		Infection with the rubella virus of the live-attenuated vaccine.
http://purl.obolibrary.org/obo/HP_0020090	Post-vaccination polio	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		Infection with live attenuated polio vaccine following vaccination. This is an extremely rare event that may indicate immunocompromise.
http://purl.obolibrary.org/obo/HP_0020091	Post-vaccination rotavirus infection	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		Infection with live attenuated rotavirus vaccine following vaccination.
http://purl.obolibrary.org/obo/HP_0020093	Recurrent deep organ abscess formation	http://purl.obolibrary.org/obo/HP_0032169	Severe infection		Repeated episodes of the formation of abscesses in organs. An abscess is a circumscribed area of pus or necrotic debris in the parenchyma or an organ.
http://purl.obolibrary.org/obo/HP_0020095	Prolonged need of intravenous antibiotic therapy	http://purl.obolibrary.org/obo/HP_0032169	Severe infection		The requirement for prolonged antibiotic treatment beyond what would be expected for a given infection in a healthy individual of the same age, suggesting unusual susceptibility to infection or failure to respond to standard therapy.
http://purl.obolibrary.org/obo/HP_0020097	Infection due to encapsulated bacteria	http://purl.obolibrary.org/obo/HP_5210000	Unusual bacterial infection		Increased susceptibility to infections with encapsulated bacteria, as manifested by recurrent or severe/invasive infection with encapsulated bacterial organisms such as Streptococcus pneumoniae, Haemophilus influenzae type b, or Neisseria meningitidis.
http://purl.obolibrary.org/obo/HP_0020099	Severe norovirus infection	http://purl.obolibrary.org/obo/HP_5210310	Unusual norovirus infection		An unusually severe course of infection with Human norovirus, previously known as Norwalk virus. Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen. Norovirus infection-associated illness may also be more prolonged and severe in immunocompromised individuals and may be associated with remarkably persistent viral excretion in some of these individuals.
http://purl.obolibrary.org/obo/HP_0020101	Invasive fungal infection	http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection		Fungal infection characterized by invasion of host tissues.
http://purl.obolibrary.org/obo/HP_0020102	Pneumocystis jirovecii pneumonia	http://purl.obolibrary.org/obo/HP_0032255	Opportunistic fungal infection		An opportunistic disease caused by invasion of unicellular fungus Pneumocystis jirovecii. Transmission of P. jirovecii cysts takes place through the airborne route, and usually, its presence in lungs is asymptomatic. However, people with impaired immunity, especially those with CD4+ T cell count below 200/microliter, are still at risk of the development of Pneumocystis pneumonia due to P. jirovecii invasion. Symptoms induced by this disease are not specific: progressive dyspnea, non-productive cough, low-grade fever, arterial partial pressure of oxygen below 65 mmHg, and chest radiographs demonstrating bilateral, interstitial shadowing.
http://purl.obolibrary.org/obo/HP_0020103	Invasive pulmonary aspergillosis	http://purl.obolibrary.org/obo/HP_0020101	Invasive fungal infection		Infection of the lungs with aspergillus. In the respiratory mucosa, the spores may germinate into hyphae, which in turn can invade the mucosa leading to invasive pulmonary aspergillosis.
http://purl.obolibrary.org/obo/HP_0020104	Unusual protozoan infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		An unusual protozoan infection that is regarded as a sign of a pathological susceptibility to infection by a protozoal agent.
http://purl.obolibrary.org/obo/HP_0020105	Severe Toxoplasma infection	http://purl.obolibrary.org/obo/HP_5210127	Unusual Toxoplasma infection		Toxoplasmosis is a widespread parasitic infection that is frequently asymptomatic in immunocompetent patients. However, this obligate intracellular protozoan parasite can evade the immune system and persist for the life of its host in cyst form, predominantly in the brain, retina, and muscles. Reactivation of latent cysts may occur when the immune system fails to maintain cytokine pressure, which mainly relies on gamma interferon (IFN-gamma). Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs).
http://purl.obolibrary.org/obo/HP_0020106	Severe giardiasis	http://purl.obolibrary.org/obo/HP_0020104	Unusual protozoan infection		An unusually severe infection due to Giardia lamblia, also called Giardia duodenalis or Giardia intestinalis, which is a protozoan parasite of the small intestine that causes extensive morbidity worldwide.
http://purl.obolibrary.org/obo/HP_0020107	Unusual helminthic infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		An unusual helminthic infection that is regarded as a sign of a pathological susceptibility to infection by a worm (helminth).
http://purl.obolibrary.org/obo/HP_0020108	Unusual parasitic infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		An unusual parasitic infection that is regarded as a sign of a pathological susceptibility to infection by a parasite.
http://purl.obolibrary.org/obo/HP_0020110	Bone fracture	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		A partial or complete breakage of the continuity of a bone.
http://purl.obolibrary.org/obo/HP_0020111	Abnormal regulatory T cell proportion	http://purl.obolibrary.org/obo/HP_0031392	Abnormal CD4+ T cell subset proportion		Abnormal increase or decrease of the regulatory (Treg) CD4+ T cell subpopulation, commonly characterized by the CD127lowCD25hi phenotype, with the optional additional positivity for FoxP3, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0020112	Increased regulatory T cell proportion	http://purl.obolibrary.org/obo/HP_0020111	Abnormal regulatory T cell proportion		Abnormal increase of the regulatory (Treg) CD4+ T cell subpopulation, commonly characterized by the CD127lowCD25hi phenotype, with the optional additional positivity for FoxP3, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0020113	Decreased regulatory T cell proportion	http://purl.obolibrary.org/obo/HP_0020111	Abnormal regulatory T cell proportion		Abnormal decrease of the regulatory (Treg) CD4+ T cell subpopulation, commonly characterized by the CD127lowCD25hi phenotype, with the optional additional positivity for FoxP3, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0020114	Persistent human papillomavirus infection	http://purl.obolibrary.org/obo/HP_0032169	Severe infection		Human papillomaviruses (HPVs) are small oncogenic viruses. HPV has been shown to cause a variety of lesions and malignancies, which predominantly affect the anogenital region. Low-risk, non-oncogenic HPV types are associated with anogenital warts and recurrent respiratory papillomatosis while high-risk, oncogenic types are associated with cervical, penile, anal, vaginal, vulvar, and oropharyngeal cancers. Infection with anogenital HPV is usually asymptomatic and resolves spontaneously without consequences in the immunocompetent host. When disease does occur, the most common manifestation is genital warts, which may be small papules, or flat, smooth or pedunculated lesions. This resolution of HPV lesions is not generally seen in the immunosuppressed, resulting in severe, persistent and extensive manifestations of HPV disease.
http://purl.obolibrary.org/obo/HP_0025616	Sterile abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		An abscess not caused by infection with pyogenic bacteria. Operationally, a sterile abscess is inferred if investigations of an abscess fail to reveal evidence of pathogenic organisms.
http://purl.obolibrary.org/obo/HP_0025617	Abnormal total plasma cell count	http://purl.obolibrary.org/obo/HP_0002846	Abnormal B cell morphology		An abnormal number of plasma cells in the blood circulation. Plasma cells are terminally differentiated B cells dedicated to the production of a high amount of antibodies.
http://purl.obolibrary.org/obo/HP_0025618	Reduced plasma cell count	http://purl.obolibrary.org/obo/HP_0025617	Abnormal total plasma cell count		An abnormally low number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies.
http://purl.obolibrary.org/obo/HP_0025619	Elevated plasma cell count	http://purl.obolibrary.org/obo/HP_0025617	Abnormal total plasma cell count		An abnormally high number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies.
http://purl.obolibrary.org/obo/HP_0025624	Decreased effector memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410386	Decreased CD4+ memory T cell proportion		An abnormally decreased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.
http://purl.obolibrary.org/obo/HP_0025625	Increased effector memory CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410391	Increased memory CD4+ T cell proportion		An abnormally increased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells may have a CD3/CD4/CD62L-/CD45RA phenotype.
http://purl.obolibrary.org/obo/HP_0025626	Increased circulating oleate level	http://purl.obolibrary.org/obo/HP_0003455	Elevated circulating long chain fatty acid concentration		An abnormally high concentration of oleic acid (oleate) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025627	Increased circulating octadecanoate level	http://purl.obolibrary.org/obo/HP_0003455	Elevated circulating long chain fatty acid concentration		An abnormally high concentration of octadecanoate in the blood circulation. Octadecanoate is a fatty acid anion 18:0 that is the conjugate base of octadecanoic acid (stearic acid).
http://purl.obolibrary.org/obo/HP_0025628	Increased circulating myristoleate level	http://purl.obolibrary.org/obo/HP_0003455	Elevated circulating long chain fatty acid concentration		An abnormally high concentration of myristoleate in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025629	Anti-myelin-associated glycoprotein antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against myelin-associated glycoprotein (MAG).
http://purl.obolibrary.org/obo/HP_0025630	Argininosuccinic aciduria	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		Increased amount of argininosuccinate in the urine.
http://purl.obolibrary.org/obo/HP_0025631	Alpha-aminobutyric aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Increased amount of alpha-aminobutyric acid in the urine.
http://purl.obolibrary.org/obo/HP_0032288	Polyclonal elevation of circulating IgG concentration	http://purl.obolibrary.org/obo/HP_0003237	Increased circulating IgG concentration		An increase in polyclonal immunoglobulins resulting from many different plasma cells. On serum electrophoresis, a polyclonal gammopathy is characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains.
http://purl.obolibrary.org/obo/HP_0032289	Oligoclonal elevation of circulating IgG concentration	http://purl.obolibrary.org/obo/HP_0003237	Increased circulating IgG concentration		An increase in circulating immunoglobulins characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.
http://purl.obolibrary.org/obo/HP_0032290	Monoclonal elevation of circulating IgG concentration	http://purl.obolibrary.org/obo/HP_0003237	Increased circulating IgG concentration		An increase in circulating immunoglobulins characterized by a single band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.
http://purl.obolibrary.org/obo/HP_0032291	Monoclonal elevation of circulating intact IgG concentration	http://purl.obolibrary.org/obo/HP_0032290	Monoclonal elevation of circulating IgG concentration		A type of monoclonal elevation of IgG in which the involved immunoglobulin has a normal structure with a light and heavy chain.
http://purl.obolibrary.org/obo/HP_0032292	Monoclonal elevation of circulating IgG light chain concentration	http://purl.obolibrary.org/obo/HP_0032290	Monoclonal elevation of circulating IgG concentration		A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a light chain but not a heavy chain.
http://purl.obolibrary.org/obo/HP_0032293	Monoclonal elevation of circulating IgG heavy chain concentration	http://purl.obolibrary.org/obo/HP_0032290	Monoclonal elevation of circulating IgG concentration		A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a heavy chain but not a light chain.
http://purl.obolibrary.org/obo/HP_0032294	Monoclonal elevation of IgG kappa chain	http://purl.obolibrary.org/obo/HP_0032292	Monoclonal elevation of circulating IgG light chain concentration		A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a kappa light chain but not a heavy chain.
http://purl.obolibrary.org/obo/HP_0032295	Monoclonal elevation of IgG lambda chain	http://purl.obolibrary.org/obo/HP_0032292	Monoclonal elevation of circulating IgG light chain concentration		A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a lambda light chain but not a heavy chain.
http://purl.obolibrary.org/obo/HP_0032296	Increased circulating IgG subclass concentration	http://purl.obolibrary.org/obo/HP_0003237	Increased circulating IgG concentration		An elevation of circulating IgG level predominantly related to an elevation of one of the four IgG subclasses.
http://purl.obolibrary.org/obo/HP_0032297	Increased circulating IgG3 concentration	http://purl.obolibrary.org/obo/HP_0032296	Increased circulating IgG subclass concentration		An abnormally increased concentration of the IgG3 subtype in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032298	Increased circulating IgG1 concentration	http://purl.obolibrary.org/obo/HP_0032296	Increased circulating IgG subclass concentration		An abnormally increased concentration of the IgG1 subtype in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032299	Increased circulating IgG2 concentration	http://purl.obolibrary.org/obo/HP_0032296	Increased circulating IgG subclass concentration		An abnormally increased concentration of the IgG2 subtype in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032300	Increased circulating IgG4 concentration	http://purl.obolibrary.org/obo/HP_0032296	Increased circulating IgG subclass concentration		An abnormally increased concentration of the IgG4 subtype in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032301	Genital warts	http://purl.obolibrary.org/obo/HP_0200043	Verrucae		Warts affecting the skin in the genital area (penile shaft, scrotum, vagina, or labia majora). Warts can be small, beginning as a pinhead-size swelling that may become larger and take on a pedunculated appearance. Warts can spread and coalesce into large masses in the genital or anal area. Their color is variable but tends to be skin colored or darker, and they may occasionally bleed. Warts may cause itching, redness, or discomfort. An outbreak of genital warts may also cause psychological distress.
http://purl.obolibrary.org/obo/HP_0032302	Kappa Bence Jones proteinuria	http://purl.obolibrary.org/obo/HP_0030156	Bence Jones Proteinuria		The presence of free monoclonal kappa immunoglobulin light chains in the urine.
http://purl.obolibrary.org/obo/HP_0032303	Lambda Bence Jones proteinuria	http://purl.obolibrary.org/obo/HP_0030156	Bence Jones Proteinuria		The presence of free monoclonal lambda immunoglobulin light chains in the urine.
http://purl.obolibrary.org/obo/HP_0032304	Abnormal circulating mannose-binding protein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of mannose-binding protein in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032305	Decreased circulating mannose-binding protein concentration	http://purl.obolibrary.org/obo/HP_0032304	Abnormal circulating mannose-binding protein concentration		The concentration of mannose-binding protein in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0032306	Elevated circulating mannose-binding protein concentration	http://purl.obolibrary.org/obo/HP_0032304	Abnormal circulating mannose-binding protein concentration		The concentration of mannose-binding protein in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032308	Increased circulating procalcitonin concentration	http://purl.obolibrary.org/obo/HP_0100530	Abnormal circulating calcium-phosphate regulating hormone concentration		An elevated concentration of procalcitonin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032310	Increased total granulocyte count	http://purl.obolibrary.org/obo/HP_0032309	Abnormal granulocyte count		An increased count of granulocytes in the peripheral blood circulation.
http://purl.obolibrary.org/obo/HP_0032312	Decreased circulating globulin concentration	http://purl.obolibrary.org/obo/HP_0032179	Abnormal circulating globulin concentration		The concentration of globulins in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0032313	Frontotemporal hypertrichosis	http://purl.obolibrary.org/obo/HP_0002219	Facial hypertrichosis		Excessive, increased hair growth located in the region of the forehead and temple.
http://purl.obolibrary.org/obo/HP_0032314	Abnormal areolar morphology	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		An abnormal appearance or structure of the ring of pigmented skin that surrounds the nipple.
http://purl.obolibrary.org/obo/HP_0032315	Areolar fullness	http://purl.obolibrary.org/obo/HP_0032314	Abnormal areolar morphology		The areola (ring of pigmented skin surrounding the nipple) is filled out so as to produce a rounded shape.
http://purl.obolibrary.org/obo/HP_0032316	Family history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Information about close relatives of an individual who is the proband of a study or who is being investigated with the goal of identifying a medical diagnosis. Usually, the family history includes information from three generations of relatives, including children, brothers and sisters, parents, aunts and uncles, nieces and nephews, grandparents, and cousins.
http://purl.obolibrary.org/obo/HP_0032317	Family history of cancer	http://purl.obolibrary.org/obo/HP_0032316	Family history		A close blood relative had cancer.
http://purl.obolibrary.org/obo/HP_0032318	Family history of heart disease	http://purl.obolibrary.org/obo/HP_0032316	Family history		A close blood relative had heart disease.
http://purl.obolibrary.org/obo/HP_0032319	Health status	http://purl.obolibrary.org/obo/HP_0032316	Family history		Health status of a family member with respect to the disease being investigated in a proband.
http://purl.obolibrary.org/obo/HP_0032320	Affected	http://purl.obolibrary.org/obo/HP_0032319	Health status		This term applies to a family member who is diagnosed with the same condition as the individual who is the primary focus of investigation (the proband).
http://purl.obolibrary.org/obo/HP_0032321	Unaffected	http://purl.obolibrary.org/obo/HP_0032319	Health status		This term applies to a family member in whom the diagnosis that is the primary focus of investigation is excluded.
http://purl.obolibrary.org/obo/HP_0032322	Healthy	http://purl.obolibrary.org/obo/HP_0032319	Health status		No history of any serious disease, including the disease being investigated in the proband.
http://purl.obolibrary.org/obo/HP_0032323	Periodic fever	http://purl.obolibrary.org/obo/HP_0001954	Recurrent fever		Episodic fever that recurs at regular intervals.
http://purl.obolibrary.org/obo/HP_0032324	Non-periodic recurrent fever	http://purl.obolibrary.org/obo/HP_0001954	Recurrent fever		Episodic fever that recurs at irregular intervals.
http://purl.obolibrary.org/obo/HP_0032325	Lacunar stroke	http://purl.obolibrary.org/obo/HP_0002140	Ischemic stroke		A stroke related to a small infarct (2-20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons, that is presumed to result from the occlusion of a single small perforating artery supplying the subcortical areas of the brain.
http://purl.obolibrary.org/obo/HP_0032326	Methicillin-resistant Staphylococcus aureus infection	http://purl.obolibrary.org/obo/HP_0032260	Opportunistic bacterial infection		Infection with staphylococcus aureus resistant to the antibiotic methicillin (MRSA). MRSA can infect any individual but is more common among hospitalized patients, and can also occur as an opportunistic infection.
http://purl.obolibrary.org/obo/HP_0032327	Interhemispheric cyst	http://purl.obolibrary.org/obo/HP_0012703	Abnormal subarachnoid space morphology		Cystic collection (sac-like, fluid containing pocket of membranous tissue) located in the interhemispheric fissure, with or without communication with the ventricular system.
http://purl.obolibrary.org/obo/HP_0032328	Temporomandibular joint adhesion	http://purl.obolibrary.org/obo/HP_0010754	Abnormality of the temporomandibular joint		Formation of one or more fibrous bands within the temporomandibular joint (TMJ) with resulting limitation of movement of the TMJ. Adhesions may be seen in degenerative processes that involve the TMJ.
http://purl.obolibrary.org/obo/HP_0032329	Increased urinary 11-deoxycortisol level	http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level		An abnormally elevated concentration of 11-deoxycortisol in the urine.
http://purl.obolibrary.org/obo/HP_0032330	Increased urinary 11-deoxycorticosterone level	http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level		An abnormally elevated concentration or amount of 11-deoxycorticosterone in the urine.
http://purl.obolibrary.org/obo/HP_0032331	Increased urinary 11-deoxytetrahydrocorticosterone level	http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level		An abnormally elevated concentration or amount of 11-deoxytetrahydrocorticosterone the urine.
http://purl.obolibrary.org/obo/HP_0032332	Oligoclonal elevation of circulating IgM concentration	http://purl.obolibrary.org/obo/HP_0003496	Increased circulating IgM concentration		An increase in circulating IgM characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase.
http://purl.obolibrary.org/obo/HP_0032333	Polyclonal elevation of circulating IgA	http://purl.obolibrary.org/obo/HP_0003261	Increased circulating IgA concentration		A heterogeneous increase in IgA mmunoglobulins characterized by a diffuse band on serum electrophoresis.
http://purl.obolibrary.org/obo/HP_0032334	Oligoclonal elevation of circulating IgA	http://purl.obolibrary.org/obo/HP_0003261	Increased circulating IgA concentration		An increase in circulating IgA characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.
http://purl.obolibrary.org/obo/HP_0032335	Monoclonal elevation of circulating IgA	http://purl.obolibrary.org/obo/HP_0003261	Increased circulating IgA concentration		An increase in circulating IgA characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.
http://purl.obolibrary.org/obo/HP_0032337	Monoclonal elevated circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0003212	Increased circulating IgE concentration		An increase in circulating IgE characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.
http://purl.obolibrary.org/obo/HP_0032338	Oligoclonal elevated circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0003212	Increased circulating IgE concentration		An increase in circulating IgE characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.
http://purl.obolibrary.org/obo/HP_0032339	Polyclonal elevated circulating IgE concentration	http://purl.obolibrary.org/obo/HP_0003212	Increased circulating IgE concentration		A heterogeneous increase in IgE mmunoglobulins characterized by a diffuse band on serum electrophoresis.
http://purl.obolibrary.org/obo/HP_0032341	Reduced forced vital capacity	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		An abnormal reduction in the amount of air a person can expel following maximal inspiration.
http://purl.obolibrary.org/obo/HP_0032342	Reduced forced expiratory volume in one second	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		An abnormal reduction in the amount of air a person can forcefully expel in one second.
http://purl.obolibrary.org/obo/HP_0032344	Upslanting toenail	http://purl.obolibrary.org/obo/HP_0008388	Abnormal toenail morphology		Upturned concavity of toenails.
http://purl.obolibrary.org/obo/HP_0032345	Elevated circulating CA19-9 concentration	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		The concentration of carbohydrate antigen 19-9 (CA19-9) in the blood circulation is above the upper limit of normal. CA 19-9, also known as sialyl Lewis A, is a tetrasaccharide overexpressed on a wide range of cancerous cells. CA 19-9 is a tumor-associated carbohydrate antigen (TACAs) that is both a local (anchored on cell surface or tumor site) and shed (in systemic circulation) antigen. CA 19-9 is expressed at low levels in normal tissues but overexpressed in cancer cells.
http://purl.obolibrary.org/obo/HP_0032346	Cutaneous lichen amyloidosis	http://purl.obolibrary.org/obo/HP_0012309	Cutaneous amyloidosis		Lichen amyloidosis presents with multiple localized or rarely generalized, hyperpigmented grouped papules with a predilection for the shins, calves, ankles, and dorsa of the feet and thighs.
http://purl.obolibrary.org/obo/HP_0032347	Cutaneous macular amyloidosis	http://purl.obolibrary.org/obo/HP_0012309	Cutaneous amyloidosis		A type of cutaneous amyloidosis that is characterized by hyperpigmented patches with indefinite margins composed of grayish brown macules, often with a reticulated or rippled appearance.
http://purl.obolibrary.org/obo/HP_0032348	Cutaneous nodular amyloidosis	http://purl.obolibrary.org/obo/HP_0012309	Cutaneous amyloidosis		A type of cutaneous amyloidosis that is characterized clinically by waxy, purpuric plaques and nodules and histologically by amyloid deposits in the dermis and subcutaneous tissue.
http://purl.obolibrary.org/obo/HP_0032349	Serinuria	http://purl.obolibrary.org/obo/HP_0033099	Increased serine family amino acid in urine		A increased concentration of serine in the urine.
http://purl.obolibrary.org/obo/HP_0032350	Sulfocysteinuria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		A increased concentration of sulfocysteine in the urine.
http://purl.obolibrary.org/obo/HP_0032351	Phenylalaninuria	http://purl.obolibrary.org/obo/HP_0033090	Increased aromatic amino acid level in urine		Increased level of phenylalanine in urine.
http://purl.obolibrary.org/obo/HP_0032352	Methioninuria	http://purl.obolibrary.org/obo/HP_0033095	Increased sulfur amino acid level in urine		Level of methionine in urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032353	Leucinuria	http://purl.obolibrary.org/obo/HP_0033089	Branched-chain aminoaciduria		Increased level of leucine in urine.
http://purl.obolibrary.org/obo/HP_0032355	Decreased peak expiratory flow	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		A reduction in the maximum expiratory flow per minute, which can be used to measure how fast a subject can exhale as well as to judge the strength of the expiratory muscles and the condition of the large airways.
http://purl.obolibrary.org/obo/HP_0032356	Decreased pre-bronchodilator forced vital capacity	http://purl.obolibrary.org/obo/HP_0032341	Reduced forced vital capacity		An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed before the administration of a bronchodilating medication.
http://purl.obolibrary.org/obo/HP_0032357	Decreased post-bronchodilator forced vital capacity	http://purl.obolibrary.org/obo/HP_0032341	Reduced forced vital capacity		An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed after the administration of a bronchodilating medication.
http://purl.obolibrary.org/obo/HP_0032358	Decreased post-bronchodilator forced expiratory volume in one second	http://purl.obolibrary.org/obo/HP_0032342	Reduced forced expiratory volume in one second		An abnormal reduction in the amount of air a person can forcefully expel in one second, with the test being performed after the administration of a bronchodilating medication.
http://purl.obolibrary.org/obo/HP_0032359	Decreased forced expiratory flow 25-75%	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled.
http://purl.obolibrary.org/obo/HP_0032360	Decreased pre-bronchodilator forced expiratory flow 25-75%	http://purl.obolibrary.org/obo/HP_0032359	Decreased forced expiratory flow 25-75%		A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled. Here, the test is performed before the administration of a bronchodilating medication.
http://purl.obolibrary.org/obo/HP_0032361	Decreased post-bronchodilator forced expiratory flow 25-75%	http://purl.obolibrary.org/obo/HP_0032359	Decreased forced expiratory flow 25-75%		A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled. Here, the test is performed after the administration of a bronchodilating medication.
http://purl.obolibrary.org/obo/HP_0032362	Increased circulating corticosterone level	http://purl.obolibrary.org/obo/HP_0012112	Abnormal circulating corticosterone level		An abnormally elevated concentration of corticosterone in the blood.
http://purl.obolibrary.org/obo/HP_0032363	Decreased circulating corticosterone level	http://purl.obolibrary.org/obo/HP_0012112	Abnormal circulating corticosterone level		An abnormally reduced concentration of corticosterone in the blood.
http://purl.obolibrary.org/obo/HP_0032365	Exacerbated by aspirin exposure	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by ingestion of aspirin.
http://purl.obolibrary.org/obo/HP_0032366	Positive direct antiglobulin test	http://purl.obolibrary.org/obo/HP_6000388	Anti-erythrocyte autoantibody positivity		A positive result of the direct antiglobulin test (DAT), a method of demonstrating the presence of antibody or complement bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction.
http://purl.obolibrary.org/obo/HP_0032369	Alkalemia	http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis		An abnormally high blood pH (usually defined as 7.41 or above).
http://purl.obolibrary.org/obo/HP_0032370	Blood group A	http://purl.obolibrary.org/obo/HP_0032224	ABO blood group		ABO phenotype A, corresponding to the genotype AO or AA.
http://purl.obolibrary.org/obo/HP_0032371	Isoleucinuria	http://purl.obolibrary.org/obo/HP_0033089	Branched-chain aminoaciduria		An increased concentration of isoleucine in the urine.
http://purl.obolibrary.org/obo/HP_0032372	Increased peripheral blast count	http://purl.obolibrary.org/obo/HP_0011893	Abnormal leukocyte count		An increased count in the peripheral blood of cells that are precursors to mature circulating blood cells such as neutrophiles, monocytes, lymphocutes, and erythrocytes. Blasts are not usually found in significant numbers in the peripheral blood circulation, but can be observed in hematopoietic neoplasms such as leukemia, severe infections, and as a result of certain medications.
http://purl.obolibrary.org/obo/HP_0032373	Duffy blood group	http://purl.obolibrary.org/obo/HP_0032223	Blood group		The Duffy blood group system is based on the presence of a glycoprotein termed Fy that is on the surface of erythrocytes and some other cells. There are two Duffy antigens named Fya and Fyb, and thus there are four Duffy phenotypes: a+b+, a+b-, a-b+,a-b-.
http://purl.obolibrary.org/obo/HP_0032374	Duffy Fya positivity	http://purl.obolibrary.org/obo/HP_0032373	Duffy blood group		Presence of the Duffy Fya antigen.
http://purl.obolibrary.org/obo/HP_0032375	Duffy Fyb positivity	http://purl.obolibrary.org/obo/HP_0032373	Duffy blood group		Presence of the Duffy Fyb antigen.
http://purl.obolibrary.org/obo/HP_0032376	Anti-beta 2 glycoprotein I antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		Presence of antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS).
http://purl.obolibrary.org/obo/HP_0032377	Increased urinary orosomucoid	http://purl.obolibrary.org/obo/HP_0020129	Abnormal urine protein level		An increased concentration in the urine of alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM). AGP is a 41-43-kDa glycoprotein with a pI of 2.8-3.8. AGP is an acute-phase protein that has many activities including, but not limited to, acting as an acute-phase reactant and disease marker, modulating immunity, binding and carrying drugs, maintaining the barrier function of capillary, and mediating the sphingolipid metabolism.
http://purl.obolibrary.org/obo/HP_0032378	Immediate-type hypersensitivity drug reaction	http://purl.obolibrary.org/obo/HP_0100326	Immunologic hypersensitivity		Hypersensitivity that is observed within 1 hr of exposures. A variety of adverse reactions can occur within minutes to hours of exposure to a drug. Some can be related to the pharmacological action of the drug (WHO Adverse Reaction Terminology type A for augmented) and usually have a low mortality. Others are not readily predictable based on the structure and pharmacological action of the drug and have a relatively high mortality risk (Type B for bizarre). The most serious form of immediate onset drug hypersensitivity reaction, anaphylaxis. Other reactions including itching, dizziness/light-headedness, nausea, chest discomfort but without any objective skin features, physical signs or physiological compromise. Skin only reactions include generalized erythema, urticaria or angioedema without any sentinel features (see below) of other organ involvement.
http://purl.obolibrary.org/obo/HP_0032379	Polymorphous light eruption	http://purl.obolibrary.org/obo/HP_0000992	Cutaneous photosensitivity		The cardinal symptom is severely pruritic skin lesions. Macular, papular, papulovesicular, urticarial, multiforme- and plaque-like variants are differentiated morphologically, hence the name polymorphous. Usually one morphology dominates in a single individual (monomorphous). The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. Distinct lesions then develop. The upper chest, upper arms, backs of the hands, thighs, and the sides of the face are the primary localizations. The skin lesions resolve spontaneously within several days of ceasing sun exposure and do not leave behind any traces.
http://purl.obolibrary.org/obo/HP_0032381	Hydroa vacciniforme	http://purl.obolibrary.org/obo/HP_0000992	Cutaneous photosensitivity		In response to the spring sun distinct inflamed reddened skin develops on the ears, nose, cheeks, fingers, backs of the hands, and the lower arms, on which blisters with serous or hemorrhagic content develop. These dry out with the formation of a blackish scab. After shedding of the scab, depressed, varioliform, often hypopigmented scars remain. In addition, hyper- and hypopigmentation are present together, resulting in a polymorphous skin presentation.
http://purl.obolibrary.org/obo/HP_0032382	Uniparental disomy	http://purl.obolibrary.org/obo/HP_0034335	Inheritance qualifier		Inheritance of both homologues of a chromosome pair from the same parent.
http://purl.obolibrary.org/obo/HP_0032383	Uniparental heterodisomy	http://purl.obolibrary.org/obo/HP_0032382	Uniparental disomy		A type of uniparental disomy in which the two different chromosomes (or chromosome segments) of the same parent are transmitted.
http://purl.obolibrary.org/obo/HP_0032384	Uniparental isodisomy	http://purl.obolibrary.org/obo/HP_0032382	Uniparental disomy		A type of uniparental disomy in which the two identical chromosomes (or chromosome segments) of the same parent are transmitted.
http://purl.obolibrary.org/obo/HP_0032385	Abnormal circulating transferrin concentration	http://purl.obolibrary.org/obo/HP_0025465	Abnormal circulating beta globulin concentration		Any deviation from the normal concentration of transferrin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032386	Elevated circulating transferrin concentration	http://purl.obolibrary.org/obo/HP_0032385	Abnormal circulating transferrin concentration		The concentration of transferrin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032387	Decreased circulating transferrin concentration	http://purl.obolibrary.org/obo/HP_0032385	Abnormal circulating transferrin concentration		The concentration of transferrin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0032388	Periventricular nodular heterotopia	http://purl.obolibrary.org/obo/HP_0007165	Periventricular heterotopia		Nodules of heterotopia along the ventricular walls. There can be a single nodule or a large number of nodules, they can exist on either or both sides of the brain at any point along the higher ventricle margins, they can be small or large, single or multiple.
http://purl.obolibrary.org/obo/HP_0032389	Periventricular laminar heterotopia	http://purl.obolibrary.org/obo/HP_0007165	Periventricular heterotopia		A large mass of heterotopia in a laminar configuration along the ventricular walls. Usually bilateral.
http://purl.obolibrary.org/obo/HP_0032390	Periventricular ribbonlike heterotopia	http://purl.obolibrary.org/obo/HP_0007165	Periventricular heterotopia		Heterotopia that forms a continuous wavy line along the ventricular wall.
http://purl.obolibrary.org/obo/HP_0032391	Subcortical heterotopia	http://purl.obolibrary.org/obo/HP_0002282	Gray matter heterotopia		A form of heterotopia were the mislocalized gray matter is located deep within the white matter.
http://purl.obolibrary.org/obo/HP_0032392	Nodular subcortical heterotopia in peritrigonal regions	http://purl.obolibrary.org/obo/HP_0032391	Subcortical heterotopia		Solid nodular heterotopia situated in the region of the peritrigonal optic pathway posterior to the deep gray nuclei.
http://purl.obolibrary.org/obo/HP_0032393	Diffuse ribbon-like subcortical heterotopia	http://purl.obolibrary.org/obo/HP_0032391	Subcortical heterotopia		Subcortical heterotopia consisting of a bilateral and symmetric single continuous, undulating ribbon-like layer of gray matter located in the frontal, parietal and occipital lobes. It has no visible connection to the overlying cortex.
http://purl.obolibrary.org/obo/HP_0032394	Mesial parasagittal subcortical heterotopia	http://purl.obolibrary.org/obo/HP_0032391	Subcortical heterotopia		Subcortical heterotopia extending along the mesial aspect of the lateral ventricles, with direct connection to mesial polymicrogyria-like cortex at the anterior and posterior limits of the heterotopia.
http://purl.obolibrary.org/obo/HP_0032395	Curvilinear subcortical heterotopia	http://purl.obolibrary.org/obo/HP_0032391	Subcortical heterotopia		Large subcortical heterotopia of variable morphology with streaks and swirls. These always connect to the overlying cortex in at least one, but usually in multiple, locations. Spaces with the signal intensity of CSF are usually seen within the heterotopia.
http://purl.obolibrary.org/obo/HP_0032396	Transmantle columnar heterotopia	http://purl.obolibrary.org/obo/HP_0032391	Subcortical heterotopia		Linear heterotopia spanning from the cerebral mantle from the pia to the ependyma.
http://purl.obolibrary.org/obo/HP_0032397	Citrullinuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of citrulline in the urine, when normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032398	Dysgyria	http://purl.obolibrary.org/obo/HP_0002536	Abnormal cortical gyration		An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation.
http://purl.obolibrary.org/obo/HP_0032399	Dysgyria with normal cortical thickness	http://purl.obolibrary.org/obo/HP_0032398	Dysgyria		An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation but with a normal thickness of the cortex.
http://purl.obolibrary.org/obo/HP_0032400	Dysgyria with thickened cortex	http://purl.obolibrary.org/obo/HP_0032398	Dysgyria		An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation and a thickened cortex intermediate between pachygyria and polymicrogyria.
http://purl.obolibrary.org/obo/HP_0032401	Aspartic aciduria	http://purl.obolibrary.org/obo/HP_0033096	Increased aspartate family amino acid level in urine		A increased concentration of aspartic acid in the urine.
http://purl.obolibrary.org/obo/HP_0032403	Asparaginuria	http://purl.obolibrary.org/obo/HP_0033096	Increased aspartate family amino acid level in urine		An increased concentration of asparagine in the urine.
http://purl.obolibrary.org/obo/HP_0032404	Testicular mass	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		An abnormal bulge or lump in a testis. A testicular mass has a long differential diagnosis including testicular torsion, epididymitis, acute orchitis, strangulated hernia and testicular cancer.
http://purl.obolibrary.org/obo/HP_0032405	Increased urinary phosphoserine level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		An increased level of phosphoserine in the urine.
http://purl.obolibrary.org/obo/HP_0032406	Unilateral perisylvian polymicrogyria	http://purl.obolibrary.org/obo/HP_0012650	Perisylvian polymicrogyria		A type of perisylvian polymicrogyria that largely affects one side of the brain.
http://purl.obolibrary.org/obo/HP_0032407	Bilateral perisylvian polymicrogyria	http://purl.obolibrary.org/obo/HP_0025646	Bilateral polymicrogyria		A type of perisylvian polymicrogyria that affects both sides of the brain.
http://purl.obolibrary.org/obo/HP_0032408	Breast mass	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		A breast lump is any discrete mass in a breast noticed by the patient, significant other, or physician.
http://purl.obolibrary.org/obo/HP_0032409	Subcortical band heterotopia	http://purl.obolibrary.org/obo/HP_0032391	Subcortical heterotopia		A form of subcortical heterotopia with mislocalized gray matter within the white matter.It is defined as longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter. It is part of the lissencephaly spectrum.
http://purl.obolibrary.org/obo/HP_0032410	Bilateral generalized polymicrogyria	http://purl.obolibrary.org/obo/HP_0025646	Bilateral polymicrogyria		Symmetric generalized polymicrogyria with no obvious gradient or region of maximal severity; may have abnormal high signal in white matter.
http://purl.obolibrary.org/obo/HP_0032411	Posterior predominant subcortical band heterotopia	http://purl.obolibrary.org/obo/HP_0032409	Subcortical band heterotopia		Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the occipital cortex.
http://purl.obolibrary.org/obo/HP_0032412	Anterior predominant subcortical band heterotopia	http://purl.obolibrary.org/obo/HP_0032409	Subcortical band heterotopia		Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible in the frontal and temporal lobes.
http://purl.obolibrary.org/obo/HP_0032413	Diffuse subcortical band heterotopia	http://purl.obolibrary.org/obo/HP_0032409	Subcortical band heterotopia		Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the whole brain.
http://purl.obolibrary.org/obo/HP_0032414	Hydroxylysinuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The presence of an elevated amount of 5-hydroxylysine in the urine. This compound is a hydroxylated derivative of the amino acid lysine that is present in certain collagens.
http://purl.obolibrary.org/obo/HP_0032415	Parasagittal parieto-occipital polymicrogyria	http://purl.obolibrary.org/obo/HP_0002126	Polymicrogyria		Polymicrogyria in parasagittal and mesial aspects of parieto-occipital cortex.
http://purl.obolibrary.org/obo/HP_0032417	Periglomerular fibrosis	http://purl.obolibrary.org/obo/HP_0031264	Abnormal Bowman capsule morphology		Circumferential fibrosis in the interstitium surrounding Bowman's capsule
http://purl.obolibrary.org/obo/HP_0032418	Abnormal HDL subfraction concentration	http://purl.obolibrary.org/obo/HP_0031888	Abnormal circulating HDL-C concentration		An abnormal concentration of an HDL subfraction, which can be determined by methods such as electrophoresis followed by densitometric determination of the areas under the peaks. Large HDL subfractions are defined as HDL1 (greater than 12 nm), HDL2b (9.7-12 nm), and HDL2a (8.8-9.69 nm). Small HDL subfractions are defined as HDL3a (8.2-8.79 nm), HDL3b (7.8-8.19 nm), and HDL3c (7.20-7.79 nm).
http://purl.obolibrary.org/obo/HP_0032419	Abnormal HDL2a concentration	http://purl.obolibrary.org/obo/HP_0032418	Abnormal HDL subfraction concentration		Any deviation from the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm.
http://purl.obolibrary.org/obo/HP_0032420	Increased HDL2a concentration	http://purl.obolibrary.org/obo/HP_0032419	Abnormal HDL2a concentration		An elevation above the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm.
http://purl.obolibrary.org/obo/HP_0032421	Decreased HDL2a concentration	http://purl.obolibrary.org/obo/HP_0032419	Abnormal HDL2a concentration		A reduction below the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm.
http://purl.obolibrary.org/obo/HP_0032422	Abnormal HDL2b concentration	http://purl.obolibrary.org/obo/HP_0032418	Abnormal HDL subfraction concentration		Any deviation from the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.
http://purl.obolibrary.org/obo/HP_0032423	Decreased HDL2b concentration	http://purl.obolibrary.org/obo/HP_0032422	Abnormal HDL2b concentration		A reduction below the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.
http://purl.obolibrary.org/obo/HP_0032424	Increased HDL2b concentration	http://purl.obolibrary.org/obo/HP_0032422	Abnormal HDL2b concentration		An elevation above the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.
http://purl.obolibrary.org/obo/HP_0032425	Abnormal HDL3a concentration	http://purl.obolibrary.org/obo/HP_0032418	Abnormal HDL subfraction concentration		Any deviation from the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.
http://purl.obolibrary.org/obo/HP_0032426	Abnormal HDL3b concentration	http://purl.obolibrary.org/obo/HP_0032418	Abnormal HDL subfraction concentration		Any deviation from the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.
http://purl.obolibrary.org/obo/HP_0032427	Abnormal HDL3c concentration	http://purl.obolibrary.org/obo/HP_0032418	Abnormal HDL subfraction concentration		Any deviation from the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.
http://purl.obolibrary.org/obo/HP_0032428	Increased HDL3a concentration	http://purl.obolibrary.org/obo/HP_0032425	Abnormal HDL3a concentration		An elevation above the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.
http://purl.obolibrary.org/obo/HP_0032429	Decreased HDL3a concentration	http://purl.obolibrary.org/obo/HP_0032425	Abnormal HDL3a concentration		A reduction below the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.
http://purl.obolibrary.org/obo/HP_0032430	Increased HDL3b concentration	http://purl.obolibrary.org/obo/HP_0032426	Abnormal HDL3b concentration		An elevation above the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.
http://purl.obolibrary.org/obo/HP_0032431	Decreased HDL3b concentration	http://purl.obolibrary.org/obo/HP_0032426	Abnormal HDL3b concentration		A reduction below the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.
http://purl.obolibrary.org/obo/HP_0032432	Increased HDL3c concentration	http://purl.obolibrary.org/obo/HP_0032427	Abnormal HDL3c concentration		An elevation above the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.
http://purl.obolibrary.org/obo/HP_0032433	Decreased HDL3c concentration	http://purl.obolibrary.org/obo/HP_0032427	Abnormal HDL3c concentration		A reduction below the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.
http://purl.obolibrary.org/obo/HP_0032434	Delayed umbilical cord separation	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		Separation of the umbilical cord occurs at an abnormally late timepoint.
http://purl.obolibrary.org/obo/HP_0032435	Neonatal omphalitis	http://purl.obolibrary.org/obo/HP_0010881	Abnormality of the umbilical cord		An infection of the umbilicus and/or surrounding tissues occurring in the neonatal period.
http://purl.obolibrary.org/obo/HP_0032436	Abnormal circulating C-reactive protein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of C-reactive protein in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032437	Decreased circulating C-reactive protein concentration	http://purl.obolibrary.org/obo/HP_0032436	Abnormal circulating C-reactive protein concentration		The concentration of C-reactive protein in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0032438	Platelet anisocytosis	http://purl.obolibrary.org/obo/HP_0011875	Abnormal platelet morphology		Abnormally increased variability in the size of platelets.
http://purl.obolibrary.org/obo/HP_0032439	Airborn particle hypersensitivity	http://purl.obolibrary.org/obo/HP_0100326	Immunologic hypersensitivity		An abnormally increased sensitivity to airborn particles. This can be diagnosed on the basis of the medical history, taking into account seasonality or a relationship to the concentration of airborn particles in the environment of the affected individual. Aerosol challenge is a gold standard of establishment of the symptom. There exist particle hypersensitivity (diesel exhaust, metals, inorganic material) vs. allergen (including pollen dander, etc) hypersensitivity. The responses are usually different and testing for allergen hypersensitivity is done in concert with serum IgE and or skin testing to the suspected allergen.
http://purl.obolibrary.org/obo/HP_0032440	Blood group B	http://purl.obolibrary.org/obo/HP_0032224	ABO blood group		ABO phenotype B, corresponding to the genotype BO or BB.
http://purl.obolibrary.org/obo/HP_0032441	Blood group AB	http://purl.obolibrary.org/obo/HP_0032224	ABO blood group		ABO phenotype AB, corresponding to the genotype AB.
http://purl.obolibrary.org/obo/HP_0032442	Blood group O	http://purl.obolibrary.org/obo/HP_0032224	ABO blood group		ABO phenotype O, corresponding to the genotype OO.
http://purl.obolibrary.org/obo/HP_0032443	Past medical history	http://purl.obolibrary.org/obo/HP_0000001	All		In a medical encounter, the physician generally will interview the patient about his or her current problem, and may perform additional testing. The past medical history (PMH) in contrast records information about the patient's medical, personal and family history that might be relevant to the presenting illness or to provide optimal clinical management. The PMH generally includes (if relevant) other major illnesses, hospitalizations, surgeries, injuries, allergies, gynecologic and obstetric history, family history, personal history including occupational history, alcohol and drug use, etc.
http://purl.obolibrary.org/obo/HP_0032444	Status post organ transplantation	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		The affected individual has received an organ transplant previous to the current medical encounter.
http://purl.obolibrary.org/obo/HP_0032446	Pulmonary bulla	http://purl.obolibrary.org/obo/HP_0002097	Emphysema		Pulmonary bullae are rounded focal regions of emphysema with a thin wall which measure more than 1 cm in diameter. They are often subpleural in location and are typically larger in the apices. In some cases, bullae can be very large and result in compression of adjacent lung tissue. A giant bulla is arbitrarily defined as one that occupies at least one third of the volume of a hemithorax. When large, bullae can simulate pneumothorax. The most common cause is paraseptal emphysema but bullae may also be seen in association with centrilobular emphysema.
http://purl.obolibrary.org/obo/HP_0032447	Pulmonary bleb	http://purl.obolibrary.org/obo/HP_0002097	Emphysema		A bleb is a small gas-containing space within the visceral pleura or in the subpleural lung, not larger than 1 cm in diameter. CT findings show a bleb as a thin-walled cystic air space contiguous with the pleura.
http://purl.obolibrary.org/obo/HP_0032448	Achlorhydria	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		A condition in which production of hydrochloric acid in the stomach is absent.
http://purl.obolibrary.org/obo/HP_0032449	Abnormal dermoepidermal hemidesmosome morphology	http://purl.obolibrary.org/obo/HP_0031538	Abnormal dermoepidermal junction morphology		An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane.
http://purl.obolibrary.org/obo/HP_0032450	Positive blood arsenic test	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		Detection of arsenic in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032451	Oral melanotic macule	http://purl.obolibrary.org/obo/HP_0100669	Abnormal pigmentation of the oral mucosa		Flat, distinct, discolored area of oral mucosal membrane less than 1 cm wide not associated with a change in the thickness or texture of the affected mucosal membrane. The lesions are small, solitary, well-circumscribed and often uniformly pigmented.
http://purl.obolibrary.org/obo/HP_0032452	Oral melanoacanthoma	http://purl.obolibrary.org/obo/HP_0100669	Abnormal pigmentation of the oral mucosa		Oral melanoacanthoma usually presents as an asymptomatic, ill-defined, rapidly enlarging, macular pigmentation. Although most lesions are heavily pigmented, the coloration may or may not be uniform. Any mucosal site may be affected, but buccal mucosal involvement is most common. Although typically solitary, rare patients may present with multifocal lesions.
http://purl.obolibrary.org/obo/HP_0032453	Abnormal lip pigmentation	http://purl.obolibrary.org/obo/HP_0000159	Abnormal lip morphology		Abnormal coloring of the lip, whereby the lip discolored, blotchy, or darker or lighter than normal.
http://purl.obolibrary.org/obo/HP_0032454	Labial melanotic macule	http://purl.obolibrary.org/obo/HP_0032453	Abnormal lip pigmentation		Flat, distinct, discolored area on the lip less than 1 cm wide not associated with a change in the thickness or texture.
http://purl.obolibrary.org/obo/HP_0032455	Reduced granulocyte CD18 level	http://purl.obolibrary.org/obo/HP_0031553	Reduced granulocyte surface marker level		Reduced level of CD18 on the granulocyte surface. This feature can be assessed by flow cytometry.
http://purl.obolibrary.org/obo/HP_0032456	Unlayered lissencephaly	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		A type of lissencephaly whereby upon neuropathological examination the cortical plate is severely disorganized with a festooned-like pattern and with neither lamination nor clear demarcation between white and gray matter.
http://purl.obolibrary.org/obo/HP_0032457	2-3-layered lissencephaly	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		Pachygyria-agyria spectrum whereby at neuropathological examination the cortical plate consists of a two-three layered organization made up of a molecular layer, a relatively thin wavy layer with a higher cellular density and a third layer with lower cellularity.
http://purl.obolibrary.org/obo/HP_0032458	Narrowing of medullary canal	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		A reduction in diameter and volume of the central cavity of bone where red or yellow bone marrow is located.
http://purl.obolibrary.org/obo/HP_0032460	Decreased phosphoribosylpyrophosphate synthetase level	http://purl.obolibrary.org/obo/HP_0032459	Abnormal phosphoribosylpyrophosphate synthetase level		Abnormally reduced level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.
http://purl.obolibrary.org/obo/HP_0032462	Increased circulating palmitate level	http://purl.obolibrary.org/obo/HP_0003455	Elevated circulating long chain fatty acid concentration		An elevation beyond the normal concentration of palmitate (palmitic acid) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032463	Reduced circulating fibronectin level	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		A reduction below the normal concentration of fibronectin the the blood circulation.
http://purl.obolibrary.org/obo/HP_0032464	Ureteral hypoplasia	http://purl.obolibrary.org/obo/HP_0025633	Abnormal ureter morphology		Underdevelopment of the ureter.
http://purl.obolibrary.org/obo/HP_0032465	Bladder trabeculation	http://purl.obolibrary.org/obo/HP_0025487	Abnormal bladder morphology		Muscular projections that protrude into the lumen of the bladder, criss-crossing the walls of the bladder on its inner surface.
http://purl.obolibrary.org/obo/HP_0032466	Aplasia of the olfactory bulb	http://purl.obolibrary.org/obo/HP_0040327	Abnormal morphology of the olfactory bulb		Lack of formation (congenital absence) of the olfactory bulb.
http://purl.obolibrary.org/obo/HP_0032467	Past obstetric history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Information about past pregnancies including gravidity (number of times a woman has been pregnant, regardless of the outcome), parity (total number of births), gestational age of births, and medical conditions related to past pregnancies.
http://purl.obolibrary.org/obo/HP_0032468	History of stillbirth	http://purl.obolibrary.org/obo/HP_0032467	Past obstetric history		One or more previous pregnancies resulted in stillbirth, defined as death of a fetus in the later stages of pregnancy (definitions in the literature vary, with cut-offs ranging from 20 to 28 weeks gestation).
http://purl.obolibrary.org/obo/HP_0032469	Anti-asialoglycoprotein receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		Presence of autoantibodies against the asialoglycoprotein receptor (ASGPR) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032470	Monilethrix	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		The hair shaft has a beaded appearance due to the presence of elliptical nodes that have the diameter of normal hair and are medullated, regularly separated by internodes that are narrow, devoid of medulla and are the site of fracture.
http://purl.obolibrary.org/obo/HP_0032471	Focal polymicrogyria	http://purl.obolibrary.org/obo/HP_0002126	Polymicrogyria		Polymicrogyria affecting one or multiple small areas of the cerebral cortex.
http://purl.obolibrary.org/obo/HP_0032472	Abnormal urine urobilinogen level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		An abnormal concentration of urobilinogen in the urine.
http://purl.obolibrary.org/obo/HP_0032473	Decreased urine urobilinogen	http://purl.obolibrary.org/obo/HP_0032472	Abnormal urine urobilinogen level		An abnormally reduced concentration of urobilinogen in the urine.
http://purl.obolibrary.org/obo/HP_0032477	Elevated circulating vitamin B6 concentration	http://purl.obolibrary.org/obo/HP_0032476	Abnormal circulating vitamin B6 concentration		An abnormally increased concentration of vitamin B6 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032478	Lateral spinal meningocele	http://purl.obolibrary.org/obo/HP_0002435	Meningocele		Protrusion of the arachnoid and dura through spinal foramina.
http://purl.obolibrary.org/obo/HP_0032479	Preimplantation lethality	http://purl.obolibrary.org/obo/HP_0033335	Abnormal preimplantation embryonic development		It is estimated that about 40-70 percent of human embryos produced in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are viable embryos, whereas others arrest at different early stages of development. The phenotype of preimplantation lethality is inferred if IVF and ICSI cycles fail because all of an individual's embryos are arrested at early stages of development.
http://purl.obolibrary.org/obo/HP_0032480	Beta-aminoisobutyric aciduria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		An increased amount of beta-aminoisobutyric acid in the urine. Beta-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.
http://purl.obolibrary.org/obo/HP_0032481	Abnormal pituitary glycoprotein hormone alpha subunit level	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Any deviation from the normal concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081).
http://purl.obolibrary.org/obo/HP_0032482	Decreased pituitary glycoprotein hormone alpha subunit level	http://purl.obolibrary.org/obo/HP_0032481	Abnormal pituitary glycoprotein hormone alpha subunit level		An reduced concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081).
http://purl.obolibrary.org/obo/HP_0032484	Elevated fecal sodium	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		An elevated concentration of sodium in feces.
http://purl.obolibrary.org/obo/HP_0032485	Abnormal fecal osmolality	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Abnormal concentration of feces as assessed by the total number of solute particles per kilogram.
http://purl.obolibrary.org/obo/HP_0032486	Elevated fecal osmolality	http://purl.obolibrary.org/obo/HP_0032485	Abnormal fecal osmolality		Abnormally high concentration of feces as assessed by the total number of solute particles per kilogram.
http://purl.obolibrary.org/obo/HP_0032487	Reduced fecal osmolality	http://purl.obolibrary.org/obo/HP_0032485	Abnormal fecal osmolality		Abnormally low concentration of feces as assessed by the total number of solute particles per kilogram.
http://purl.obolibrary.org/obo/HP_0032488	Abnormal fecal pH	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Any deviation from the normal pH of feces. The pH reflects the acidity or alkalinity of a solution on a logarithmic scale on which 7 is neutral, whereby lower values are more acid and higher values more alkaline.
http://purl.obolibrary.org/obo/HP_0032489	Elevated fecal pH	http://purl.obolibrary.org/obo/HP_0032488	Abnormal fecal pH		Abnormally high fecal pH, i.e., abnormal alkalinity of feces.
http://purl.obolibrary.org/obo/HP_0032490	Decreased fecal pH	http://purl.obolibrary.org/obo/HP_0032488	Abnormal fecal pH		Abnormally low fecal pH, i.e., abnormal acidity of feces.
http://purl.obolibrary.org/obo/HP_0032491	Increased circulating argininosuccinic acid	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An increased level of the non-proteinogenic amino acid argininosuccinic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0032492	Anti-myelin oligodendrocyte glycoprotein antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		Presence of antibodies in the serum that react against myelin oligodendrocyte glycoprotein.
http://purl.obolibrary.org/obo/HP_0032493	Elevated circulating trypsinogen concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of trypsinogen in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032495	Abnormal terminal:vellus ratio	http://purl.obolibrary.org/obo/HP_0010720	Abnormal hair pattern		A deviation from the normal proportion of terminal to vellus hairs.
http://purl.obolibrary.org/obo/HP_0032496	Elevated terminal:vellus ratio	http://purl.obolibrary.org/obo/HP_0032495	Abnormal terminal:vellus ratio		An increased proportion of terminal hairs compared to vellus hairs.
http://purl.obolibrary.org/obo/HP_0032497	Reduced terminal:vellus ratio	http://purl.obolibrary.org/obo/HP_0032495	Abnormal terminal:vellus ratio		A terminal:vellus ratio under 4:1 is characteristic of androgenetic alopecia.
http://purl.obolibrary.org/obo/HP_0410327	Dairy allergy	http://purl.obolibrary.org/obo/HP_0500093	Food allergy		Hypersensitivity in form of an adverse immune reaction against dairy.
http://purl.obolibrary.org/obo/HP_0500238	Abnormal CSF albumin concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Any deviation from the normal concentration of albumin in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/GO_0140353	lipid export from cell	http://purl.obolibrary.org/obo/GO_0006869	lipid transport		The directed movement of a lipid from a cell, into the extracellular region.
http://purl.obolibrary.org/obo/CL_0009010	transit amplifying cell	http://purl.obolibrary.org/obo/CL_0000000	cell		Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells.
http://purl.obolibrary.org/obo/CL_0009011	transit amplifying cell of colon	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the colon. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.
http://purl.obolibrary.org/obo/CL_0009012	transit amplifying cell of small intestine	http://purl.obolibrary.org/obo/CL_0002254	epithelial cell of small intestine		A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.
http://purl.obolibrary.org/obo/CL_0009016	intestinal crypt stem cell of large intestine	http://purl.obolibrary.org/obo/CL_0002253	epithelial cell of large intestine		An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.
http://purl.obolibrary.org/obo/CL_0009017	intestinal crypt stem cell of small intestine	http://purl.obolibrary.org/obo/CL_0002254	epithelial cell of small intestine		An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.
http://purl.obolibrary.org/obo/CL_0009018	lymphocyte of large intestine lamina propria	http://purl.obolibrary.org/obo/CL_0000542	lymphocyte		A lymphocyte that resides in the lamina propria of the large intestine.
http://purl.obolibrary.org/obo/CL_0009019	nephrogenic zone cell	http://purl.obolibrary.org/obo/CL_0002681	kidney cortical cell		A kidney cortical cell that is part of the nephrogenic zone.
http://purl.obolibrary.org/obo/CL_0010017	zygote	http://purl.obolibrary.org/obo/CL_0000000	cell		A zygote in a plant or an animal.
http://purl.obolibrary.org/obo/CL_0011027	skeletal muscle fibroblast	http://purl.obolibrary.org/obo/CL_1001609	muscle fibroblast		Any fibroblast that is part of skeletal muscle tissue.
http://purl.obolibrary.org/obo/CL_0019020	extrahepatic cholangiocyte	http://purl.obolibrary.org/obo/CL_1000488	cholangiocyte		An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes.
http://purl.obolibrary.org/obo/CL_0019021	endothelial cell of periportal hepatic sinusoid	http://purl.obolibrary.org/obo/CL_1000398	endothelial cell of hepatic sinusoid		An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid.
http://purl.obolibrary.org/obo/CL_0019022	endothelial cell of pericentral hepatic sinusoid	http://purl.obolibrary.org/obo/CL_1000398	endothelial cell of hepatic sinusoid		An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid.
http://purl.obolibrary.org/obo/CL_4006000	fibroblast of breast	http://purl.obolibrary.org/obo/CL_0000057	fibroblast		A fibroblast that is part of the breast.
http://purl.obolibrary.org/obo/CL_4006001	fibroblast of skin of scalp	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		A fibroblast that is part of the skin of scalp.
http://purl.obolibrary.org/obo/HP_0033362	Recurrent coughing spasms	http://purl.obolibrary.org/obo/HP_0012735	Cough		Repeated occurrence of episodes of coughing, with each episode consisting of at least five minutes of continuous coughing.
http://purl.obolibrary.org/obo/HP_0033363	Hyaline membranes	http://purl.obolibrary.org/obo/HP_0033137	Abnormal pulmonary alveolar system morphology		Hyaline membranes are homogeneous eosinophilic material composed of cellular debris, plasma proteins, and surfactant plastered against alveolar ducts and alveolar walls. The hyaline membranes are deposited along the walls of the alveoli, where gas exchange typically occurs, thereby making gas exchange difficult.
http://purl.obolibrary.org/obo/HP_0033364	Lipoid pneumonia	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		A specific form of lung inflammation that results from accumulation of lipids in the alveoli. Lipoid pneumonia can be either exogenous or endogenous in cause based on the source of the lipid.
http://purl.obolibrary.org/obo/HP_0033365	Endogenous lipoid pneumonia	http://purl.obolibrary.org/obo/HP_0033364	Lipoid pneumonia		A type of lipoid pneumonia in which the source of the lipids is the body itself. When an airway is obstructed, it is often the case that distal to the obstruction, lipid-laden macrophages and giant cells fill the lumen of the disconnected airspace.
http://purl.obolibrary.org/obo/HP_0033366	Exogenous lipoid pneumonia	http://purl.obolibrary.org/obo/HP_0033364	Lipoid pneumonia		A type of lipoid pneumonia in which the source of the lipids is external to the body.
http://purl.obolibrary.org/obo/HP_0033367	Orthodeoxia	http://purl.obolibrary.org/obo/HP_0012418	Hypoxemia		Low level of blood oxygen induced by changing from a recumbent to an upright position.
http://purl.obolibrary.org/obo/HP_0033368	Platypnea	http://purl.obolibrary.org/obo/HP_0002094	Dyspnea		A type of dyspnea that occurs when the affected person changes from a recumbent to an upright position.
http://purl.obolibrary.org/obo/HP_0033369	Cavitating leukodystrophy	http://purl.obolibrary.org/obo/HP_0002415	Leukodystrophy		A type of leukodystrophy characterized by multiple small cavitations typically in the periventricular and deep cerebral white matter. The cavitations are visible as a central cavity with cerebrospinal fluid-like signal intensity.
http://purl.obolibrary.org/obo/HP_0033370	Bronchial telangiectasia	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		Telangiectasias (small dilated blood vessels located near the surface of the skin or mucous membranes) located in the trachoebronchial system.
http://purl.obolibrary.org/obo/HP_0033371	Bronchocentric granulomatosis	http://purl.obolibrary.org/obo/HP_0030250	Pulmonary granulomatosis		Granulomatous inflammation that surrounds the bronchi and bronchioles, replacing bronchial walls and mucosa. In bronchocentric granulomatosis, the lumen of the airway contains necrotic debris, and palisaded histiocytes surround the lumen.
http://purl.obolibrary.org/obo/HP_0033372	Abnormal KCO	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		Any deviation from the normal range of KCO. The KCO is a measurement of the rate constant for alveolar uptake of CO during breath-holding in the single breath measurement of DLCO at full inflation. The DLCO is derived as the product of the KCO and the single breath alveolar volume (VA) divided by PB-PH2O.
http://purl.obolibrary.org/obo/HP_0033373	Increased KCO	http://purl.obolibrary.org/obo/HP_0033372	Abnormal KCO		Increased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index).
http://purl.obolibrary.org/obo/HP_0033374	Decreased KCO	http://purl.obolibrary.org/obo/HP_0033372	Abnormal KCO		Decreased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index).
http://purl.obolibrary.org/obo/HP_0033375	Anthracosis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Anthracosis is the deposition of black carbon pigment. It is commonly seen in perihilar lymph nodes as well as within lung parenchyma. There can be prominent storiforming (i.e., spiral patterning) of histiocytes, to such an extent as to mimic a neoplastic lesion histologically. Anthracosis is a common finding in smokers and polluted city dwellers.
http://purl.obolibrary.org/obo/HP_0033376	Alveolar septal thickening	http://purl.obolibrary.org/obo/HP_0033137	Abnormal pulmonary alveolar system morphology		Increased width of the alveolar septum, which is the structure that separates neighboring alveoli. This finding can be appreciated on histology.
http://purl.obolibrary.org/obo/HP_0033377	Increased airway neuroendocrine cells	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Presence of increased numbers of bombesin-immuno-positive neuroendocrine cells (NECs) within distal airways. There are no formal criteria for an increase (which is also dependent on the sensitivity of the staining method), findings of neuroendocrine cells in at least 70% of bronchioles by lung biopsy and at least 10% NECs in an individual airway are consistent with the diagnosis of Neuroendocrine cell hyperplasia of infancy in the appropriate clinical setting. Increases are also seen in other clinical settings. Neuroendocrine neoplasms of the lung encompass NE tumors (NETs), which split into typical and atypical carcinoids, and NE carcinomas (NECs).
http://purl.obolibrary.org/obo/HP_0033378	Increased airway neuroepithelial bodies	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Presence of increased numbers of bombesin-immuno-positive neuroendocrine cell cluster (neuroepithelial bodies) in the alveolar ducts.
http://purl.obolibrary.org/obo/HP_0033380	Nasal chondritis	http://purl.obolibrary.org/obo/HP_0100662	Chondritis		Inflammation of the cartilage of the nose.
http://purl.obolibrary.org/obo/HP_0033381	Elevated circulating stearoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035020	Elevated circulating C18 acylcarnitine concentration		Abnormally increased concentration of O-stearoylcarnitine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033382	Elevated circulating palmitoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035021	Elevated circulating C16 acylcarnitine concentration		Abnormally increased concentration of palmitoylcarnitine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033383	Decreased compound muscle action potential amplitude	http://purl.obolibrary.org/obo/HP_0030179	Abnormal peripheral action potential amplitude		Reduced level of the compound muscle action potential (CMAP), which is recorded following electrical stimulation of a nerve from surface electrodes overlying a muscle supplied by that nerve.
http://purl.obolibrary.org/obo/HP_0033384	Elevated urinary collagen degradation products	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Increased level in the urine of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease.
http://purl.obolibrary.org/obo/HP_0033385	Elevated urine pyridinoline level	http://purl.obolibrary.org/obo/HP_0033384	Elevated urinary collagen degradation products		An increased amount of pyridinoline in the urine.
http://purl.obolibrary.org/obo/HP_0033386	Abnormal circulating collagen degradation product concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		Abnormal concentration in the blood circulation of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease.
http://purl.obolibrary.org/obo/HP_0033387	Elevated circulating pyridinoline concentration	http://purl.obolibrary.org/obo/HP_0033386	Abnormal circulating collagen degradation product concentration		An increased concentration of hydroxylysyl-pyridinoline (pyridinoline) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033388	Abnormal bronchial artery morphology	http://purl.obolibrary.org/obo/HP_0011004	Abnormal systemic arterial morphology		Any structural abnormality of a bronchial artery.
http://purl.obolibrary.org/obo/HP_0033389	Bronchopulmonary anastomosis	http://purl.obolibrary.org/obo/HP_0033388	Abnormal bronchial artery morphology		Abnormal arterial anastomosis (connection) between bronchial and pulmonary arteries.
http://purl.obolibrary.org/obo/HP_0033390	Bronchial artery dilatation	http://purl.obolibrary.org/obo/HP_0033388	Abnormal bronchial artery morphology		Increased caliber of a bronchial artery, which can be defined as a bronchial artery diameter that exceeds 2 mm.
http://purl.obolibrary.org/obo/HP_0033391	Bronchial artery hypertrophy	http://purl.obolibrary.org/obo/HP_0033388	Abnormal bronchial artery morphology		Increase in the volume of bronchial artery wall due to the enlargement of its component cells.
http://purl.obolibrary.org/obo/HP_0033392	Perivascular pre-capillary pulmonary artery inflammation	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Inflammatory cell infiltration surrounding precapillary pulmonary arteries (arterioles; 20-70 micrometer).
http://purl.obolibrary.org/obo/HP_0033393	Irregularly shaped sperm tail	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		Irregular or changing caliber (diameter) along the tail of the sperm.
http://purl.obolibrary.org/obo/HP_0033394	Anti-carbonic anhydrase II antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase II.
http://purl.obolibrary.org/obo/HP_0033395	Antilactoferrin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against lactoferrin.
http://purl.obolibrary.org/obo/HP_0033396	Glomerular extracapillary fibrin	http://purl.obolibrary.org/obo/HP_0033312	Abnormal Bowman space morphology		Presence of ropey, eosinophilic material (brght red on Trichrome staining) consistent with extracapillary fibrin outside of capillary lumina.
http://purl.obolibrary.org/obo/HP_0033397	Bowman-space proteinaceous debris	http://purl.obolibrary.org/obo/HP_0033312	Abnormal Bowman space morphology		The presence of eosinophilic Periodic Acid Schiff (PAS)-positive cell free, protein-derived material occupying Bowman's space.
http://purl.obolibrary.org/obo/HP_0033398	Pleural plaque	http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology		Deposits of hyalinized collagen fibers in the parietal pleura (preferentially pleura adjacent to ribs, particularly the sixth through ninth ribs).
http://purl.obolibrary.org/obo/HP_0033399	Persistent fever	http://purl.obolibrary.org/obo/HP_0001945	Fever		Fever that persists longer than expected for an acute infectious disease. No precise threshold exists, and the clinical interpretation of fever is context-dependent, but as a rule of thumb, this term refers to fever that persists longer than 2-3 weeks.
http://purl.obolibrary.org/obo/HP_0033400	Acute abdomen	http://purl.obolibrary.org/obo/HP_0002027	Abdominal pain		A sudden onset of abdominal pain with associated nausea or vomiting. The acute abdomen may be caused by an infection, inflammation, vascular occlusion, or obstruction.
http://purl.obolibrary.org/obo/HP_0033402	Digital ischemia	http://purl.obolibrary.org/obo/HP_0033401	Tissue ischemia		Restriction of arterial blood supply to a digit (finger or toe) associated with insufficient oxygenation to support the metabolic requirements of the digit. Clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis.
http://purl.obolibrary.org/obo/HP_0033403	Testicular ischemia	http://purl.obolibrary.org/obo/HP_0033401	Tissue ischemia		Restriction of arterial blood supply to a testis associated with insufficient oxygenation to support the metabolic requirements of the tissue. Clinical manifestations may include pain and swelling of the affected testis.
http://purl.obolibrary.org/obo/HP_0033404	Intestinal ischemia	http://purl.obolibrary.org/obo/HP_0033401	Tissue ischemia		Restriction of arterial blood supply to the intestine associated with insufficient oxygenation to support the metabolic requirements of the tissue. Acute intestinal ischemia can involve the small or large intestine, and usually presents with sudden severe non-specific abdominal pain.
http://purl.obolibrary.org/obo/HP_0033405	Abnormal circulating organic amino compound concentration	http://purl.obolibrary.org/obo/HP_0004364	Abnormal circulating nitrogen compound concentration		Any deviation from the normal concentration of organic amino compound in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033406	Elevated circulating phosphoethanolamine concentration	http://purl.obolibrary.org/obo/HP_0033405	Abnormal circulating organic amino compound concentration		An increased concentration of o-phosphoethanolamine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033407	Elevated urine acetoacetic acid level	http://purl.obolibrary.org/obo/HP_0002919	Ketonuria		Elevated amount of acetoacetic acid in the urine.
http://purl.obolibrary.org/obo/HP_0033408	Elevated circulating acetoacetic acid concentration	http://purl.obolibrary.org/obo/HP_0410175	Hyperketonemia		An increased level of acetoacetic acid in the blood circulation. Acetoacetic acid is one of the predominant ketone bodies.
http://purl.obolibrary.org/obo/HP_0033409	Elevated urinary 2-hydroxybutyric acid	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		An increased amount of 2-hydroxybutyric acid in the urine.
http://purl.obolibrary.org/obo/HP_0033410	Elevated circulating cartilage oligomeric matrix protein concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of cartilage oligomeric matrix protein in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033411	Lower extremity akinesia	http://purl.obolibrary.org/obo/HP_0002304	Akinesia		Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the lower extremities.
http://purl.obolibrary.org/obo/HP_0033412	Upper extremity akinesia	http://purl.obolibrary.org/obo/HP_0002304	Akinesia		Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the upper extremities.
http://purl.obolibrary.org/obo/HP_0033413	Upper extremity hypokinesia	http://purl.obolibrary.org/obo/HP_0002375	Hypokinesia		Abnormally diminished movement of the upper extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.
http://purl.obolibrary.org/obo/HP_0033414	Lower extremity hypokinesia	http://purl.obolibrary.org/obo/HP_0002375	Hypokinesia		Abnormally diminished movement of the lower extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.
http://purl.obolibrary.org/obo/HP_0033415	Cardiac tamponade	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		The accumulation of pericardial fluid with subsequent compression of all cardiac chambers which prevents cardiac filling.
http://purl.obolibrary.org/obo/HP_0033416	Hip adductor weakness	http://purl.obolibrary.org/obo/HP_0003749	Pelvic girdle muscle weakness		Reduced ability to bring the leg toward the midline of the body.
http://purl.obolibrary.org/obo/HP_0033417	Elevated circulating hydroxybutyric acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		An increased concentration in the blood circulation of a hydroxybutyric acid, that is, of a compound comprising a butyric acid core carrying at least one hydroxy substituent.
http://purl.obolibrary.org/obo/HP_0033418	Elevated circulating 2-hydroxybutyric acid concentration	http://purl.obolibrary.org/obo/HP_0033417	Elevated circulating hydroxybutyric acid concentration		Elevation of the 2-hydroxybutyric acid concentration in the blood above the normal range.
http://purl.obolibrary.org/obo/HP_0033419	Elevated circulating 3-hydroxybutyric acid concentration	http://purl.obolibrary.org/obo/HP_0033417	Elevated circulating hydroxybutyric acid concentration		Elevation of the 3-hydroxybutyric acid concentration in the blood above the normal range.
http://purl.obolibrary.org/obo/HP_0033420	Pulmonary arterial plexiform lesion	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Focal proliferation of pulmonary artery endothelial cells, leading to the formation of complex capillary-like channels.
http://purl.obolibrary.org/obo/HP_0033421	Pulmonary artery intimal thickening	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Increased thickness of the intimal layer of the pulmonary artery. Throughout the pulmonary arterial tree, the thin intima consists of a non-fenestrated monolayer of endothelial cells lining the vessel lumen, as well as a sub-endothelial interstitium that extends to the internal elastic lamina. Intimal thickness in human lung ranges from 1-16% of total wall thickness. Pulmonary artery intimal thickening can be defined as a relative intima thickness to the thickness of the vessel wall of over 10%.
http://purl.obolibrary.org/obo/HP_0033422	Pulmonary artery adventitial fibrosis	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Increased amount of collagen, proteoglycans, and other extracellular matrix proteins resulting in scarring and thickening in the adventia of the pulmonary arterial tree.
http://purl.obolibrary.org/obo/HP_0033423	Pulmonary arterial hypertension with positive acute response to NO challenge	http://purl.obolibrary.org/obo/HP_0002092	Pulmonary arterial hypertension		A form of pulmonary arterial hypertension in which there is a reduction of mean pulmonary artery pressure (mPAP) at least 10 mmHg to reach an absolute value of mPAP not more than 40 mmHg with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm.
http://purl.obolibrary.org/obo/HP_0033424	Pulmonary arterial hypertension with lack of acute response to NO challenge	http://purl.obolibrary.org/obo/HP_0002092	Pulmonary arterial hypertension		A form of pulmonary arterial hypertension with lack of adequate hemodynamic response to NO challenge (adequate response is defined as a reduction of mean pulmonary artery pressure (mPAP) of at least 10 mmHg to reach an absolute value of mPAP 40 mmHg or less with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm).
http://purl.obolibrary.org/obo/HP_0033425	Periungual erythema	http://purl.obolibrary.org/obo/HP_0100803	Abnormal periungual morphology		Erythema (redness of the skin caused by hyperemia in superficial capillaries) in the region surrounding a fingernail or toe nail.
http://purl.obolibrary.org/obo/HP_0033426	Pulmonary air embolism	http://purl.obolibrary.org/obo/HP_0002204	Pulmonary embolism		Venous air embolism is a consequence of air being introduced into the venous circulation, and subsequently to the right heart, and pulmonary circulation. When small amounts of air reach pulmonary circulation they can be removed by gas diffusion across the arteriolar wall into the alveoli, amounts of gas exceeding 50 ml can cause pulmonary outflow tract obstruction with or without concomitant arterial embolisation.
http://purl.obolibrary.org/obo/HP_0033427	Pulmonary capillary angioectasia	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		Focal accumulation of dilated pulmonary capillaries.
http://purl.obolibrary.org/obo/HP_0033428	Systemic autoinflammation	http://purl.obolibrary.org/obo/HP_0012649	Increased inflammatory response		Dysregulation of the innate immune system characterized by systemic pathobiology, i.e., with symptoms that can affect the entire body.
http://purl.obolibrary.org/obo/HP_0033430	Non-infectious meningitis	http://purl.obolibrary.org/obo/HP_0033429	Neuroinflammation		Inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space between the meninges (subarachnoid space) when it is caused by disorders that are not infections or by drugs or vaccines.
http://purl.obolibrary.org/obo/HP_0033431	Cytomegalovirus colitis	http://purl.obolibrary.org/obo/HP_5210182	Unusual viral colitis		Infection and inflammation of the colon caused by cytomegalovirus (CMV) infection that occurs in the context of unusual susceptibility to infection.
http://purl.obolibrary.org/obo/HP_0033433	Ileocecal ulcer	http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer		An erosion of the mucous membrane in the region connecting the ileum and cecum.
http://purl.obolibrary.org/obo/HP_0033434	Nasal septum perforation	http://purl.obolibrary.org/obo/HP_0000419	Abnormal nasal septum morphology		A full-thickness defect of the nasal septum.
http://purl.obolibrary.org/obo/HP_0033435	Abnormal circulating keto acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		Any deviation from the normal concentration of a keto acid (also called ketoacid or oxo carboxylic acid) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033436	Elevated circulating 3-methyl-2-oxovaleric acid concentration	http://purl.obolibrary.org/obo/HP_0033435	Abnormal circulating keto acid concentration		The concentration of 3-methyl-2-oxovaleric acidin the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033437	Elevated circulating 4-methyl-2-oxopentanoic acid concentration	http://purl.obolibrary.org/obo/HP_0033435	Abnormal circulating keto acid concentration		The concentration of 4-methyl-2-oxopentanoic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033438	Elevated circulating myoglobin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		An increased blood concentration of myoglobin.
http://purl.obolibrary.org/obo/HP_0033439	Elevated circulating decenoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration		The concentration of decenoylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033440	Elevated circulating octenoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035017	Elevated circulating medium-chain acylcarnitine concentration		The concentration of O-octenoylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033441	Elevated circulating hexanoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035026	Elevated circulating C6 acylcarnitine concentration		The concentration of hexanoylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033442	Elevated circulating glutarylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035019	Elevated circulating C5 acylcarnitine concentration		Concentration of glutarylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033443	Elevated circulating propionylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035015	Elevated circulating short-chain acylcarnitine concentration		The concentration of propionylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033444	Elevated circulating dodecanoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0430143	Elevated circulating C12 acylcarnitine concentration		Concentration of dodecanoylcarnitine (C12:0) in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033445	Reduced circulating acylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0012071	Abnormal circulating acylcarnitine concentration		An abnormally reduced concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine.
http://purl.obolibrary.org/obo/HP_0033446	Elevated circulating butyrylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035016	Elevated circulating C4-acylcarnitine concentration		Concentration of O-butyrylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033447	Elevated circulating isovalerylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035019	Elevated circulating C5 acylcarnitine concentration		Concentration of O-isovalerylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033448	Increased mid-arm muscle circumference	http://purl.obolibrary.org/obo/HP_0001457	Abnormality of the musculature of the upper arm		Elevation of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children.
http://purl.obolibrary.org/obo/HP_0033449	Decreased mid-arm muscle circumference	http://purl.obolibrary.org/obo/HP_0001457	Abnormality of the musculature of the upper arm		Reduction of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children.
http://purl.obolibrary.org/obo/HP_0033450	Abnormal circulating prealbumin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of prealbumin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033451	Elevated circulating prealbumin concentration	http://purl.obolibrary.org/obo/HP_0033450	Abnormal circulating prealbumin concentration		The concentration of prealbumin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033453	Limited neck extension	http://purl.obolibrary.org/obo/HP_0005986	Limitation of neck motion		Reduced ability to move the head back towards the ceiling so that one is looking upwards.
http://purl.obolibrary.org/obo/HP_0033456	Elevated urine keto acid level	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		Increased amount of a keta acid in the urine.
http://purl.obolibrary.org/obo/HP_0033457	Elevated urine 3-methyl-2-oxovaleric acid level	http://purl.obolibrary.org/obo/HP_0033456	Elevated urine keto acid level		Increased amount of 3-methyl-2-oxovaleric acid in the urine.
http://purl.obolibrary.org/obo/HP_0033458	Elevated urine 4-methyl-2-oxopentanoic acid level	http://purl.obolibrary.org/obo/HP_0033456	Elevated urine keto acid level		Increased amount of 4-methyl-2-oxopentanoic acid in the urine.
http://purl.obolibrary.org/obo/HP_0033459	Decreased circulating apolipoprotein concentration	http://purl.obolibrary.org/obo/HP_0025201	Abnormal circulating apolipoprotein concentration		The concentration of apolipoprotein in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033461	Elevated circulating 3-hydroxylinoleylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035020	Elevated circulating C18 acylcarnitine concentration		Increased concentration of 3-hydroxylinoleylcarnitine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033462	Elevated circulating oleylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035020	Elevated circulating C18 acylcarnitine concentration		Increased concentration of oleylcarnitine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033464	Elevated circulating 3-hydroxypalmitoleylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035021	Elevated circulating C16 acylcarnitine concentration		Concentration of 3-hydroxypalmitoleylcarnitine in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033465	Elevated circulating tetradecanoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035018	Elevated circulating long-chain acylcarnitine concentration		The concentration of tetradecanoylcarnitine in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033466	Weak grip	http://purl.obolibrary.org/obo/HP_0030237	Hand muscle weakness		Reduced grip strength. Gripping is the motion by which the hand tightly grasps an object or other hand.
http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score	http://purl.obolibrary.org/obo/HP_0030917	Low APGAR score		A normal APGAR score can be coded as 'not Low 10-minute APGAR score'.
http://purl.obolibrary.org/obo/HP_0033475	Limited shoulder abduction	http://purl.obolibrary.org/obo/HP_0006467	Limited shoulder movement		Decreased ability to move the arm away from the midline of the body.
http://purl.obolibrary.org/obo/HP_0033478	Increased circulating lipoprotein lipase concentration	http://purl.obolibrary.org/obo/HP_0033477	Abnormal circulating lipoprotein lipase concentration		Increased concentration of lipoprotein lipase in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033480	Hypobilirubinemia	http://purl.obolibrary.org/obo/HP_0033479	Abnormal circulating bilirubin concentration		Concentration of bilirubin in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0033481	Limited lateral neck flexion	http://purl.obolibrary.org/obo/HP_0005986	Limitation of neck motion		Reduced range of motion resulting in decreased ability to move the ear toward the top of the shoulder.
http://purl.obolibrary.org/obo/HP_0033482	Limited shoulder flexion	http://purl.obolibrary.org/obo/HP_0006467	Limited shoulder movement		A reduced ability to flex the shoulder. Shoulder flexion is the motion that moves the arms from a resting position by the side of the body to a position above the head.
http://purl.obolibrary.org/obo/HP_0033483	Podocyte infolding	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Folding of cytoplasmic processes of podocytes into the glomerular basement membrane (GBM) with thickening of the lamina densa and microspheres and/or microtubular structures within the GBM.
http://purl.obolibrary.org/obo/HP_0033484	Elevated circulating linoleylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0035020	Elevated circulating C18 acylcarnitine concentration		Increased concentration of linoleylcarnitine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033485	Glomerular basement membrane disruption	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		A point of rupture in the glomerular basement membrane (GBM) where the discontinuous portions of GBM are still identifiable with a basement membrane stain such as Periodic acid Schiff (PAS) or silver.
http://purl.obolibrary.org/obo/HP_0033486	Abnormal glomerular basement membrane texture	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Anomalous appearance or structure of the surface of the glomerular basement membrane.
http://purl.obolibrary.org/obo/HP_0033487	Glomerular basement membranes powdery deposit	http://purl.obolibrary.org/obo/HP_0033486	Abnormal glomerular basement membrane texture		Punctate electron-dense material typically in a band-like distribution along the lamina rara interna and within tubular basement membranes within the subendothelial aspect of the glomerular basement membrane.
http://purl.obolibrary.org/obo/HP_0033488	Glomerular endocapillary leukocyte hypercellularity	http://purl.obolibrary.org/obo/HP_0025363	Glomerular endocapillary hypercellularity		Increased number of leukocytes internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries.
http://purl.obolibrary.org/obo/HP_0033489	Glomerular endocapillary neutrophil hypercellularity	http://purl.obolibrary.org/obo/HP_0033488	Glomerular endocapillary leukocyte hypercellularity		Increased number of neutrophils internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries.
http://purl.obolibrary.org/obo/HP_0033490	Glomerular endocapillary foam-cell hypercellularity	http://purl.obolibrary.org/obo/HP_0033488	Glomerular endocapillary leukocyte hypercellularity		Presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in the glomerulus often occupying the endocapillary space.
http://purl.obolibrary.org/obo/HP_0033491	Global mesangial sclerosis	http://purl.obolibrary.org/obo/HP_0033232	Abnormal glomerular mesangial matrix morphology		A generalized global (over 80%) increase of mesangial matrix that is present throughout the mesangial stalk (with or without associated mesangial hypercellularity).
http://purl.obolibrary.org/obo/HP_0033492	Podocyte cytoskeletal condensation	http://purl.obolibrary.org/obo/HP_0031265	Abnormal glomerular visceral epithelial cell morphology		Reorganization of podocyte cytoskeletal proteins at the glomerular basement membrane (GBM) aspect of the cell, with associated cytoplasmic electron density at the GBM aspect of the podocyte.
http://purl.obolibrary.org/obo/HP_0033493	Mesangial matrix expansion	http://purl.obolibrary.org/obo/HP_0033232	Abnormal glomerular mesangial matrix morphology		Increased mesangial extracellular material with interspace width of over 2 mesangial cell nuclei, in one or more peripheral mesangial areas.
http://purl.obolibrary.org/obo/HP_0033494	Glomerular basement membrane amyloid spicule	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Amyloid spicules are projections of typically silver-positive material from the outer aspect of the glomerular capillary wall, perpendicular to the glomerular basement membrane (GBM), most often caused by amyloidosis with the latter confirmed by additional stains.
http://purl.obolibrary.org/obo/HP_0033495	Segmental glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0000096	Glomerular sclerosis		Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration and can include hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman capsule.
http://purl.obolibrary.org/obo/HP_0033496	Perihilar segmental glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0033495	Segmental glomerulosclerosis		Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration is present at the vascular pole, involving less than 50% of the tuft. It can be accompanied by other descriptors such as hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman's capsule.
http://purl.obolibrary.org/obo/HP_0033497	Tip variant segmental glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0033495	Segmental glomerulosclerosis		Segmental solidification of the glomerular tuft characterized by an adhesion at the tip of the glomerular tuft abutting the proximal tubular taek-off can be accompanied by increased extracellular matrix, causing glomerular capillary obliteration at the glomerular tip. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed.
http://purl.obolibrary.org/obo/HP_0033498	Segmental glomerulosclerosis away from the vascular and tubular poles	http://purl.obolibrary.org/obo/HP_0033495	Segmental glomerulosclerosis		Segmental solidification of the glomerular tuft characterized by increased extracellular matrix, causing glomerular capillary obliteration at neither the tubular or vascular poles. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed.
http://purl.obolibrary.org/obo/HP_0033499	Glomerular basement membrane electron dense deposits	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Electron-dense deposits in the lamina densa with a ribbon or a sausage structure.
http://purl.obolibrary.org/obo/HP_0033500	Subendothelial glomerular basement membrane electron dense deposits	http://purl.obolibrary.org/obo/HP_0033499	Glomerular basement membrane electron dense deposits		Electron dense deposits in the glomerular basement membrane (GBM) subendothelial space associated with a prominent GBM reflecting an increase in thickness. This feature can be associated with GBM remodeling along the endothelial aspect.
http://purl.obolibrary.org/obo/HP_0033501	Subepithelial glomerular basement membrane electron dense deposits	http://purl.obolibrary.org/obo/HP_0033499	Glomerular basement membrane electron dense deposits		Prominent glomerular basement membrane (GBM) reflecting a diffuse and relatively uniform increase in thickness (subjective estimate) with exogenous material deposited between the outer (epithelial) aspect of the GBM and the visceral epithelial cell, with varying degrees of incorporation into the GBM.
http://purl.obolibrary.org/obo/HP_0033502	Abnormal esterified to free carnitine ratio	http://purl.obolibrary.org/obo/HP_0012071	Abnormal circulating acylcarnitine concentration		Any deviation from the normal ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.
http://purl.obolibrary.org/obo/HP_0033503	Elevated CSF fumarate concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		An increased concentration of fumarate, an intermediate in the citric acid cycle, in the cebrebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0033504	Elevated circulating fumarate concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		An increased concentration of fumarate, an intermediate in the citric acid cycle, in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033505	Livedo reticularis	http://purl.obolibrary.org/obo/HP_0033832	Livedo		Livedo reticularis is characterized by the presence of a bluish purple, mottled or netlike pattern in unbroken circles on the skin. Exposure to cold environments usually intensifies the vascular pattern. Presumably, the condition results from slow or stagnant blood flow, vessel-wall pathology, and decreased oxygen tension.
http://purl.obolibrary.org/obo/HP_0033506	Increased esterified to free carnitine ratio	http://purl.obolibrary.org/obo/HP_0033502	Abnormal esterified to free carnitine ratio		An elevated ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.
http://purl.obolibrary.org/obo/HP_0033507	Decreased esterified to free carnitine ratio	http://purl.obolibrary.org/obo/HP_0033502	Abnormal esterified to free carnitine ratio		A reduced ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.
http://purl.obolibrary.org/obo/HP_0033508	EBV meningitis	http://purl.obolibrary.org/obo/HP_5210216	Viral meningitis		Inflammation of the meninges related to infection by Epstein-Barr virus.
http://purl.obolibrary.org/obo/HP_0033509	EBV encephalitis	http://purl.obolibrary.org/obo/HP_0033993	Viral encephalitis		Inflammation of the brain related to infection by Epstein-Barr virus.
http://purl.obolibrary.org/obo/HP_0033510	Cutaneous horn	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A cutaneous horn is a keratinized non-malignant protrusion on the surface of the skin. Diagnosis is established by biopsy of the horn and biopsy of the horn and the underlying skin.
http://purl.obolibrary.org/obo/HP_0033511	Addictive substance use	http://purl.obolibrary.org/obo/HP_0030858	Addictive behavior		Chronic compulsive drug seeking and continued use despite harmful consequences.
http://purl.obolibrary.org/obo/HP_0033512	Addictive stimulant use	http://purl.obolibrary.org/obo/HP_0033511	Addictive substance use		Addiction to a stimulant drug is defined as a drug that typically increases alertness, attention, and energy while also elevating blood pressure, heart rate, and breathing.
http://purl.obolibrary.org/obo/HP_0033513	Addictive cocaine use	http://purl.obolibrary.org/obo/HP_0033512	Addictive stimulant use		Addiction to cocaine.
http://purl.obolibrary.org/obo/HP_0033514	Addictive amphetamine use	http://purl.obolibrary.org/obo/HP_0033512	Addictive stimulant use		Addiction to amphetamine or dextroamphetamine is a serious concern.
http://purl.obolibrary.org/obo/HP_0033515	Addictive opioid use	http://purl.obolibrary.org/obo/HP_0033511	Addictive substance use		Addiction to opioids.
http://purl.obolibrary.org/obo/HP_0033516	Addictive benzodiazepine use	http://purl.obolibrary.org/obo/HP_5200331	Addictive sedative use		Addiction to a benzodiazepine.
http://purl.obolibrary.org/obo/HP_0033517	Addictive heroin use	http://purl.obolibrary.org/obo/HP_0033515	Addictive opioid use		Addiction to heroin.
http://purl.obolibrary.org/obo/HP_0033518	Addictive methylphenidate use	http://purl.obolibrary.org/obo/HP_0033512	Addictive stimulant use		Addiction to methylphenidate.
http://purl.obolibrary.org/obo/HP_0033519	Addictive methamphetamine use	http://purl.obolibrary.org/obo/HP_0033512	Addictive stimulant use		Addiction to methamphetamine.
http://purl.obolibrary.org/obo/HP_0033520	Paradoxical embolism	http://purl.obolibrary.org/obo/HP_0001907	Thromboembolism		Paradoxical embolism describes the passage of a venous or right-sided cardiac thrombus into the arterial or systemic circulation.
http://purl.obolibrary.org/obo/HP_0033521	Nasal dryness	http://purl.obolibrary.org/obo/HP_0000433	Abnormal nasal mucosa morphology		A lack of humidification of the nasal mucosa.
http://purl.obolibrary.org/obo/HP_0033522	Cerebral cavernous malformation	http://purl.obolibrary.org/obo/HP_0100659	Abnormal cerebral vascular morphology		A cerebral cavernous malformation (also known as cavernoma, cavernous angioma, cavernous hemangioma) is a collection of structurally abnormal slow-flow capillaries predominantly in the central nervous system. These are multiple mulberry-like distended caverns of dilated thin-walled capillaries without the normal intervening brain parenchymal architecture. Often, individual cavernomas are surrounded by hemosiderin representing remote oozing due to the abnormal capillaries.
http://purl.obolibrary.org/obo/HP_0033523	Abnormal sperm principal piece morphology	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		A structural anomaly of the part of the sperm flagellum that is distal to the sperm midpiece and mitochondrial sheath and which leads into the end piece.
http://purl.obolibrary.org/obo/HP_0033524	Abnormal sperm axoneme morphology	http://purl.obolibrary.org/obo/HP_0012864	Abnormal sperm morphology		Abnormal structure of the sperm axonemal structure which consists of a ring of nine microtubular doublets and a central pair of microtubules, giving the classical 9+2 microtubular arrangement. The axoneme contains a central pair of microtubules (C1 and C2) that are connected by a bridge-like structure forming the central pair complex (CPC). Each of the nine outer doublets is composed of type A and B microtubules and connected by radial spokes to the CPC.
http://purl.obolibrary.org/obo/HP_0033525	Absent sperm axoneme central pair complex	http://purl.obolibrary.org/obo/HP_0033524	Abnormal sperm axoneme morphology		Absence of the central pair of microtubules in the sperm axoneme, thereby forming a 9+0 pattern instead of the normal 9+2 pattern.
http://purl.obolibrary.org/obo/HP_0033526	Limited ankle dorsiflexion	http://purl.obolibrary.org/obo/HP_0010505	Limitation of movement at ankles		Reduced ability to move the foot up toward the shin.
http://purl.obolibrary.org/obo/HP_0033527	Decreased gonadotropin-stimulated testosterone-to-androstenedione ratio	http://purl.obolibrary.org/obo/HP_0030347	Abnormal circulating androgen level		A reduced amount of testosterone relative in androstenedione in the blood circulation following administration of hCG (Human Chorionic Gonadotropin).
http://purl.obolibrary.org/obo/HP_0033528	Abnormal cardiac output	http://purl.obolibrary.org/obo/HP_0011028	Abnormality of blood circulation		A deviation from normal Cardiac output, which is defined as the amount of blood pumped by the heart minute and is the mechanism whereby blood flows around the body, especially providing blood flow to the brain and other vital organs.
http://purl.obolibrary.org/obo/HP_0033529	Abnormal cardiac index	http://purl.obolibrary.org/obo/HP_0033528	Abnormal cardiac output		Any deviation from the normal value of the cardiac index, defined as cardiac output divided by body surface area.
http://purl.obolibrary.org/obo/HP_0033530	Increased cardiac index	http://purl.obolibrary.org/obo/HP_0033529	Abnormal cardiac index		An elevated cardiac index, defined as cardiac output divided by body surface area.
http://purl.obolibrary.org/obo/HP_0033531	Decreased cardiac index	http://purl.obolibrary.org/obo/HP_0033529	Abnormal cardiac index		A reduced cardiac index, defined as cardiac output divided by body surface area.
http://purl.obolibrary.org/obo/HP_0033532	Decreased cardiac output	http://purl.obolibrary.org/obo/HP_0033528	Abnormal cardiac output		A decreased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat.
http://purl.obolibrary.org/obo/HP_0033533	Increased cardiac output	http://purl.obolibrary.org/obo/HP_0033528	Abnormal cardiac output		An increased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat.
http://purl.obolibrary.org/obo/HP_0033534	Increased circulating brain natriuretic peptide concentration	http://purl.obolibrary.org/obo/HP_0031138	Abnormal circulating B-type natriuretic peptide concentration		An increased concentration of brain natriuretic peptide in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033535	Reduced platelet dense granules	http://purl.obolibrary.org/obo/HP_0012530	Abnormal number of dense granules		Decreased number of platelet dense granules, a type of platelet organelle.
http://purl.obolibrary.org/obo/HP_0033536	Reduced platelet alpha granules	http://purl.obolibrary.org/obo/HP_0012528	Abnormal number of alpha granules		A reduced number of platelet alpha granules.
http://purl.obolibrary.org/obo/HP_0033537	Mosaic pulmonary attenuation pattern	http://purl.obolibrary.org/obo/HP_0025389	Pulmonary interstitial high-resolution computed tomography abnormality		Mosaic attenuation refers to heterogeneous areas of differing pulmonary attenuation on CT imaging.
http://purl.obolibrary.org/obo/HP_0033538	Aortic annulus calcification	http://purl.obolibrary.org/obo/HP_0004380	Aortic valve calcification		Pathological deposition of calcium salts in the aortic annulus, a fibrous ring-like structure found at the insertion point of the basal attachments of the aortic valve leaflets within the left ventricular outflow tract.
http://purl.obolibrary.org/obo/HP_0033539	Bilateral apical pulmonary fibrosis	http://purl.obolibrary.org/obo/HP_0002206	Pulmonary fibrosis		A reticular pattern of linear or lineonodular densities in apical portions of both the right and left lungs seen initially on high-resolution computed tomography and in case of progression also on standard chest x-ray.
http://purl.obolibrary.org/obo/HP_0033540	Reversible airflow obstruction	http://purl.obolibrary.org/obo/HP_0006536	Airway obstruction		Airflow obstruction with a significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL.
http://purl.obolibrary.org/obo/HP_0033541	Irreversible airflow obstruction	http://purl.obolibrary.org/obo/HP_0006536	Airway obstruction		Airflow obstruction without significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL.
http://purl.obolibrary.org/obo/HP_0033542	Bronchial wall thickening	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Radiological appearance of increased density around the walls of a bronchus or large bronchiole. This feature is thought to be related to edema involving the bronchial wall as well as the peribronchial interstitial space. If the cross section of a bronchus is captured in a radiograph or computed tomography image, it is said to have the appearance of a donut because of the central lucency representing the airway of the bronchus surrounded by a circular region of increased density.
http://purl.obolibrary.org/obo/HP_0033543	Addictive nicotine use	http://purl.obolibrary.org/obo/HP_0033511	Addictive substance use		Nicotine addiction can be defined as a chronic, compulsive craving for nicotine and continued usage despite harmful consequences.
http://purl.obolibrary.org/obo/HP_0033544	Mesangial fibril deposition	http://purl.obolibrary.org/obo/HP_0001966	Abnormal glomerular mesangium morphology		Extracellular mesangial accumulation of slender proteinaceous fibers.
http://purl.obolibrary.org/obo/HP_0033545	Mesangial fibrillary deposits	http://purl.obolibrary.org/obo/HP_0033544	Mesangial fibril deposition		Extracellular mesangial aggregates composed of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material.
http://purl.obolibrary.org/obo/HP_0033546	Mesangial microfibril deposition	http://purl.obolibrary.org/obo/HP_0033544	Mesangial fibril deposition		Unbranched noncollagenous microfibrils within the mesangial matrix, composed of proteins not present within the glomerular basement membrane (GBM), most notably fibrillin-1, that attach to mesangial cells and GBM structural proteins.
http://purl.obolibrary.org/obo/HP_0033547	Mesangial immunotactoid deposits	http://purl.obolibrary.org/obo/HP_0033544	Mesangial fibril deposition		Extracellular mesangial aggregates composed of non-branching fibrils, focally parallel over 30 nM in diameter. The term immunotactoid refers to highly organized immune depositions appearing as rod-like microtubular structures in ultrastructural examination.
http://purl.obolibrary.org/obo/HP_0033548	Mesangial amyloid deposition	http://purl.obolibrary.org/obo/HP_0033544	Mesangial fibril deposition		Extracellular mesangial aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass.
http://purl.obolibrary.org/obo/HP_0033549	Nodular mesangiosclerosis	http://purl.obolibrary.org/obo/HP_0033232	Abnormal glomerular mesangial matrix morphology		Lobular, round to oval mesangial lesions with an acellular hyaline/matrix core surrounded by compressed mesangial nuclei.
http://purl.obolibrary.org/obo/HP_0033550	Necrotizing pulmonary granulomatosis	http://purl.obolibrary.org/obo/HP_0030250	Pulmonary granulomatosis		A granuloma that is associated with necrotic changes. Caseation necrosis is defined as a region in granulomas with eosinophilic, granular and cheese-like cellular debris with necrosis. The word caseous itself means pertaining or related to cheese, and comes from the Latin word caseus, meaning cheese.
http://purl.obolibrary.org/obo/HP_0033551	Non-necrotizing pulmonary granulomatosis	http://purl.obolibrary.org/obo/HP_0030250	Pulmonary granulomatosis		A granuloma located in the lung that is not associated with necrotic changes.
http://purl.obolibrary.org/obo/HP_0033552	Chronic villitis	http://purl.obolibrary.org/obo/HP_0011409	Abnormal placental membrane morphology		Villitis of unknown etiology (synonymous with villitis of unknown etiology) is a histologic diagnosis and, although it may have a variable distribution, evidence indicates that 3 parenchymal blocks will identify 62% of villitis, reaching an asymptote of 6 and 7 blocks identifying 85% of villitis. Villitis of unknown etiology by definition excludes those cases where an etiology is identified, such as viral or acute infections, and thus is preferred to the term nonspecific chronic villitis. It is usually lymphohistiocytic: although the presence of rare plasma cells does not exclude the diagnosis, thorough evaluation for an infectious etiology, such as cytomegalovirus, is required in a predominantly plasma cell villitis.
http://purl.obolibrary.org/obo/HP_0033553	Septic embolism	http://purl.obolibrary.org/obo/HP_0001907	Thromboembolism		Embolization of intravascular thrombus containing microorganisms into the distant tissues via arterial system.
http://purl.obolibrary.org/obo/HP_0033554	Anti-Mi2 antibody positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		The presence of autoantibodies in the blood circulation that react against the Mi-2 antigen.
http://purl.obolibrary.org/obo/HP_0033555	Anti-Ro/SS-A antibody positivity	http://purl.obolibrary.org/obo/HP_0033476	Extractable nuclear antigen positivity		The presence of autoantibodies in the blood circulation that react against Ro/SSA autoantigens.
http://purl.obolibrary.org/obo/HP_0033556	Anti-nucleoporin 62 antibody positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against nucleoporin 62.
http://purl.obolibrary.org/obo/HP_0033557	Anti-proteinase 3 antibody positivity	http://purl.obolibrary.org/obo/HP_0032230	Cytoplasmic antineutrophil antibody positivity		The presence of autoantibodies in the blood circulation that react against proteinase 3. Proteinase 3 (PR3) antigen is a 29-kD serine protease that exists as a protein triplet in human neutrophils
http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		The presence of autoantibodies in the blood circulation that react against histone antigens.
http://purl.obolibrary.org/obo/HP_0033559	Anti-myeloperoxidase antibody positivity	http://purl.obolibrary.org/obo/HP_0032229	Perinuclear antineutrophil antibody positivity		The presence of autoantibodies in the blood circulation that react against myeloperoxidase.
http://purl.obolibrary.org/obo/HP_0033560	Anti-PM-Scl antibody positivity	http://purl.obolibrary.org/obo/HP_0003493	Antinuclear antibody positivity		Anti-PM-Scl antibodies target components of RNA-processing exosome complex in the nucleolus. There are ten proteins in this complex and antibodies to eight of them are found at varying frequencies; PM/Scl-100, PM/Scl-75, hRrp4, hRrp42, hRrp46, hCs14, hRrp41, and hRrp40.
http://purl.obolibrary.org/obo/HP_0033561	Anti-bactericidal/permeability-increasing protein antibody positivity	http://purl.obolibrary.org/obo/HP_0032230	Cytoplasmic antineutrophil antibody positivity		The presence of autoantibodies in the blood circulation that react against bactericidal/permeability-increasing protein (BPI). BPI is an endotoxin-binding host protein with important antibacterial effects against Gram-negative bacteria, such as Pseudomonas aeruginosa. BPI is a 55 kDalton protein that is most abundant in the azurophilic granules of neutrophils. BPI also acts as a target antigen for antineutrophil cytoplasmic autoantibodies.
http://purl.obolibrary.org/obo/HP_0033562	Anti-glycoprotein-210 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against glycoprotein-210.
http://purl.obolibrary.org/obo/HP_0033563	Anti-tissue transglutaminase antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against tissue transglutaminase.
http://purl.obolibrary.org/obo/HP_0033564	Stasis dermatitis	http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis		Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Stasis dermatitis presents initially as poorly demarcated erythematous plaques of the lower legs bilaterally, classically involving the medial malleolus.
http://purl.obolibrary.org/obo/HP_0033565	Anti-epidermal transglutaminase antibody positivity	http://purl.obolibrary.org/obo/HP_0033563	Anti-tissue transglutaminase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against epidermal transglutaminase.
http://purl.obolibrary.org/obo/HP_0033566	Abnormal ventricular axis	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		Any deviation from the normal direction of the ventricular axis. The left ventricle makes up most of the heart muscle under normal circumstances and therefore generates the most electrical force visible on the EKG. The normal ventricular axis is directed downward and slightly towards the left. The ventricular axis can be determined by analyzing the QRS complex, which represents ventricular depolarization.
http://purl.obolibrary.org/obo/HP_0033567	Right axis deviation	http://purl.obolibrary.org/obo/HP_0033566	Abnormal ventricular axis		A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between +90 degrees and 180 degrees, or beyond +100 degrees if the adult range is used.
http://purl.obolibrary.org/obo/HP_0033568	Left axis deviation	http://purl.obolibrary.org/obo/HP_0033566	Abnormal ventricular axis		A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between -30 degrees and -90 degrees.
http://purl.obolibrary.org/obo/HP_0033569	Extreme axis deviation	http://purl.obolibrary.org/obo/HP_0033566	Abnormal ventricular axis		A kind of abnormal ventricular axis in the EKG whereby the QRS axis fall sbetween -90 degrees and 180 degrees. In this case, the ventricular vector is directed upward and to the right.
http://purl.obolibrary.org/obo/HP_0033570	Indeterminate ventricular axis	http://purl.obolibrary.org/obo/HP_0033566	Abnormal ventricular axis		A kind of abnormal ventricular axis in the EKG whereby the QRS complex is isoelectric or equiphasic in all leads with no dominant QRS deflection.
http://purl.obolibrary.org/obo/HP_0033571	Peripheral lung neovascularity	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		The presence of small, tortuous, micronodular, serpiginous intrapulmonary vessels often in the subpleural lung or in proximity to centrilobular arterioles, coursing in directions inconsistent with known arteriolar anatomy.
http://purl.obolibrary.org/obo/HP_0033572	Anti-H1 antibody positivity	http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity		The presence of autoantibodies in the blood circulation that react against histone H1.
http://purl.obolibrary.org/obo/HP_0033573	Anti-H4 antibody positivity	http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity		The presence of autoantibodies in the blood circulation that react against histone H4.
http://purl.obolibrary.org/obo/HP_0033574	Anti-H3 antibody positivity	http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity		The presence of autoantibodies in the blood circulation that react against histone H3.
http://purl.obolibrary.org/obo/HP_0033575	Anti-H2A antibody positivity	http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity		The presence of autoantibodies in the blood circulation that react against histone H2A.
http://purl.obolibrary.org/obo/HP_0033576	Anti-H2B antibody positivity	http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity		The presence of autoantibodies in the blood circulation that react against histone H2B.
http://purl.obolibrary.org/obo/HP_0033577	In situ pulmonary artery thrombosis	http://purl.obolibrary.org/obo/HP_0030966	Abnormal pulmonary artery morphology		Localized thrombosis in pulmonary arteries frequently found in patients with idiopathic and hereditary pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease.
http://purl.obolibrary.org/obo/HP_0033579	Decreased growth hormone responses to growth hormone-releasing hormone challenge	http://purl.obolibrary.org/obo/HP_0000824	Decreased response to growth hormone stimulation test		Insufficient growth hormone secretion following administration of growth hormone-releasing hormone.
http://purl.obolibrary.org/obo/HP_0033580	Compound motor action potential abnormality	http://purl.obolibrary.org/obo/HP_0040131	Abnormal motor nerve conduction velocity		An abnormal finding in a compound motor action potential measurement in EMG. Nerve conduction studies involve the application of a depolarising square wave electrical pulses to the skin over a peripheral nerve producing: (1) a propagated nerve action potential (NAP) recorded at a distant point over the same nerve: and (2) a compound muscle action potential (CMAP) arising from the activation of muscle fibers in a target muscle supplied by the nerve. In both cases these may be recorded with surface or needle electrodes. The CMAP is a summated voltage response from the individual muscle fiber action potentials. The shortest latency of the CMAP is the time from stimulus artifact to onset of the response and is a biphasic response with an initial upward deflection followed by a smaller downward deflection. The CMAP amplitude is measured from baseline to negative peak (the neurophysiological convention is that negative voltage is demonstrated by an upward deflection) and measured in millivolts (mV).
http://purl.obolibrary.org/obo/HP_0033581	Absent peripheral lymph nodes in presence of infection	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		The absence of any palpable lymph nodes in the presence of symptoms suggesting infection in that drainage area should raise suspicion for immunodeficiency diseases.
http://purl.obolibrary.org/obo/HP_0033583	Follicular bronchiolitis	http://purl.obolibrary.org/obo/HP_0033582	Pulmonary interstitial lymphocyte infiltration		Follicular bronchiolitis is a polyclonal hyperplasia of bronchiolar associated lymphoid tissue characterized by the is characterized by the development of lymphoid follicles with germinal centers in walls of the small airways.
http://purl.obolibrary.org/obo/HP_0033584	Nonspecific interstitial pneumonia	http://purl.obolibrary.org/obo/HP_0006515	Interstitial pneumonitis		Temporally uniform (all lesions are in the same stage of evolution) pattern of diffuse inflammatory interstitial process, mostly symmetric over the entire lung, involving mainly the alveolar septa.
http://purl.obolibrary.org/obo/HP_0033585	Fibrotic non-specific interstitial pneumonia	http://purl.obolibrary.org/obo/HP_0033584	Nonspecific interstitial pneumonia		A type of non-specific interstitial pneumonia in which interstitial thickening is due to uniform dense or loose fibrosis and mild chronic inflammation.
http://purl.obolibrary.org/obo/HP_0033586	Cellular non-specific interstitial pneumonia	http://purl.obolibrary.org/obo/HP_0033584	Nonspecific interstitial pneumonia		A type of non-specific interstitial pneumonia in which interstitial thickening is mainly due to infiltration of inflammatory cells and type II pneumocyte hyperplasia.
http://purl.obolibrary.org/obo/HP_0033587	Vulvar abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A circumscribed area of pus or necrotic debris in the vulvar region.
http://purl.obolibrary.org/obo/HP_0033588	Labial adhesion	http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology		Synechia vulvae (adhesions of the labia minora) are characterized by a complete or partial fusion of the labia minora in the midline.
http://purl.obolibrary.org/obo/HP_0033589	Flatulence	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Passage of excessive amounts of gas and the feeling of abdominal fullness and bloating.
http://purl.obolibrary.org/obo/HP_0033590	Inguinal abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		A circumscribed area of pus or necrotic debris in the groin (inguinal region).
http://purl.obolibrary.org/obo/HP_0033591	Staghorn calculus	http://purl.obolibrary.org/obo/HP_0000787	Kidney stone		Large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system.
http://purl.obolibrary.org/obo/HP_0033592	Anti-H3-H4 antibody positivity	http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity		The presence of autoantibodies in the blood circulation that react against the H3-H4 histone dimer.
http://purl.obolibrary.org/obo/HP_0033593	Anti-H2A-H2B antibody positivity	http://purl.obolibrary.org/obo/HP_0033558	Anti-histone antibody positivity		The presence of autoantibodies in the blood circulation that react against the H2A-H2B histone dimer.
http://purl.obolibrary.org/obo/HP_0033594	Elevated urinary 7-biopterin level	http://purl.obolibrary.org/obo/HP_0040416	Abnormal urinary nitrogen compound level		An abnormally increased amount of 7-biopterin in the urine.
http://purl.obolibrary.org/obo/HP_0033595	Elevated circulating globotriaosylceramide concentration	http://purl.obolibrary.org/obo/HP_0004343	Abnormal glycosphingolipid metabolism		Increased concentration of globotriaosylceramide (Gb3) in the blood circulation. Globotriaosylceramide, also named ceramidetrihexoside, is the primary lipid storage in Fabry disease.
http://purl.obolibrary.org/obo/HP_0033596	Elevated urinary 3-methylcrotonylglycine level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An abnormally increased amount of 3-methylcrotonylglycine in the urine.
http://purl.obolibrary.org/obo/HP_0033597	Decreased mucosal sucrase-isomaltase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced activity of the linked disaccharidase, sucrase-isomaltase, which is a glycoprotein localized to the brush border membrane of small intestinal villi.
http://purl.obolibrary.org/obo/HP_0033598	Fibrillar glomerular subepithelial deposits	http://purl.obolibrary.org/obo/HP_0033603	Glomerular subepithelial deposits		Fibrillar deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).
http://purl.obolibrary.org/obo/HP_0033599	Glomerular amyloid subepithelial deposits	http://purl.obolibrary.org/obo/HP_0033598	Fibrillar glomerular subepithelial deposits		A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).
http://purl.obolibrary.org/obo/HP_0033600	Fibrillary glomerular subepithelial deposits	http://purl.obolibrary.org/obo/HP_0033598	Fibrillar glomerular subepithelial deposits		A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).
http://purl.obolibrary.org/obo/HP_0033601	Glomerular subepithelial immune-complex deposits	http://purl.obolibrary.org/obo/HP_0033603	Glomerular subepithelial deposits		A type of glomerular subepithelial deposit characterized by finely granular material deposited between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM and corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).
http://purl.obolibrary.org/obo/HP_0033602	Glomerular hyaline subepithelial deposits	http://purl.obolibrary.org/obo/HP_0033603	Glomerular subepithelial deposits		A type of glomerular subepithelial deposit characterized by a moderately electron-dense, generally homogenous, amorphous-appearing extracellular material located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).
http://purl.obolibrary.org/obo/HP_0033603	Glomerular subepithelial deposits	http://purl.obolibrary.org/obo/HP_0030949	Glomerular deposits		Deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature may be associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).
http://purl.obolibrary.org/obo/HP_0033604	Glomerular capillary wire loop deposits	http://purl.obolibrary.org/obo/HP_0030949	Glomerular deposits		Glomerulus showing markedly and irregularly thickened capillary walls with massive fuchsinophilic subendothelial deposits, resulting in narrowing of capillary lumina. This feature is said to resemble a wire loop.
http://purl.obolibrary.org/obo/HP_0033605	Pustular rash	http://purl.obolibrary.org/obo/HP_0000988	Skin rash		A rash composed of pustular lesions. A pustule is defined as a vesicle or bulla containing purulent material. It varies in size and may occur at different levels within the epidermis: subcorneal, intraepidermal, or basement membrane zones. The pustules may or may not be sterile and are normally filled with neutrophils.
http://purl.obolibrary.org/obo/HP_0033606	Bone marrow maturation arrest	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		Interruption of the procecss of diffferentiation of hematopoietic cells in the bone marrow, manifested by an increased proportion of immature cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0033607	Bone marrow arrest at the promyelocytic stage	http://purl.obolibrary.org/obo/HP_0033606	Bone marrow maturation arrest		A type of bone marrow maturation arrest characterized by accumulation of neutrophil precursor cells in the bone marrow.
http://purl.obolibrary.org/obo/HP_0033608	Pulmonary nodule	http://purl.obolibrary.org/obo/HP_0031983	Abnormal pulmonary thoracic imaging finding		Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging.
http://purl.obolibrary.org/obo/HP_0033609	Solid pulmonary nodule	http://purl.obolibrary.org/obo/HP_0033608	Pulmonary nodule		A type of pulmonary nodule whose density obscures the underlying parenchyma and thus has a "solid" appearance.
http://purl.obolibrary.org/obo/HP_0033610	Subsolid pulmonary nodule	http://purl.obolibrary.org/obo/HP_0033608	Pulmonary nodule		Pulmonary subsolid nodules (SSNs) refer to pulmonary nodules with pure ground-glass nodules and part-solid ground-glass nodules. A ground-glass nodule (GGN) is the morphologic description of a pulmonary nodule category on thin-section chest computed tomography (CT). During the past decade, the natural history, management strategy and long-term prognosis in the case of GGNs have attracted attention.
http://purl.obolibrary.org/obo/HP_0033611	Part-solid pulmonary nodule	http://purl.obolibrary.org/obo/HP_0033610	Subsolid pulmonary nodule		Part-solid pulmonary nodules are nodules that present with both ground-glass and solid components in which the underlying lung architecture cannot be visualized.
http://purl.obolibrary.org/obo/HP_0033612	Pure ground-glass pulmonary nodule	http://purl.obolibrary.org/obo/HP_0033610	Subsolid pulmonary nodule		Pure ground-glass pulmonary nodules (GGNs) are defined as focal nodular areas of increased lung attenuation through which lung parenchymal structures, such as the pulmonary vessels or bronchial structures, can be observed.
http://purl.obolibrary.org/obo/HP_0033613	Perifissural pulmonary nodule	http://purl.obolibrary.org/obo/HP_0033608	Pulmonary nodule		Solid, homogenous nodules characterized by a smooth margin and oval, rounded, lentiform or triangular shape. They are typically located within 15 mm from the issue or the pleura. Perifissural nodules may be further differentiated into typical (have contact with interlobar septum) and atypical (do not have contact with interlobar septum). They likely represent intrapulmonary lymphnodes.
http://purl.obolibrary.org/obo/HP_0033614	Tracheal bronchus	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Aberrant or accessory bronchus supplying the upper lobe originating from the lateral wall of the trachea. The tracheal bronchus is more commonly right-sided, has a variable length and may be blind-ended. Two common types of tracheal bronchus are: supernumerary and displaced.
http://purl.obolibrary.org/obo/HP_0033615	Displaced tracheal bronchus	http://purl.obolibrary.org/obo/HP_0033614	Tracheal bronchus		Accessory bronchus originating from trachea replacing one of the segmental branches of the anatomically normal upper lobe bronchus.
http://purl.obolibrary.org/obo/HP_0033616	Accessory cardiac bronchus	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Accessory bronchus originating from the medial wall of the right or left ban bronchus or bronchus intermedius. A cardiac bronchus is usually blind-ended.
http://purl.obolibrary.org/obo/HP_0033617	Supernumerary tracheal bronchus	http://purl.obolibrary.org/obo/HP_0033614	Tracheal bronchus		Accessory bronchus which exits the trachea in addition to an anatomically normal branching upper lobe bronchus.
http://purl.obolibrary.org/obo/HP_0033618	Displaced lobar tracheal bronchus	http://purl.obolibrary.org/obo/HP_0033614	Tracheal bronchus		Accessory entire right upper lobe bronchial system originating from the trachea with absent anatomically normal upper lobe bronchus.
http://purl.obolibrary.org/obo/HP_0033619	Typical perifissural nodule	http://purl.obolibrary.org/obo/HP_0033613	Perifissural pulmonary nodule		A perifissural nodule that has contact with the interlobar septum (and is therefore considered typical).
http://purl.obolibrary.org/obo/HP_0033620	Atypical perifissural nodule	http://purl.obolibrary.org/obo/HP_0033613	Perifissural pulmonary nodule		A perifissural nodule that does not have contact with the interlobar septum (and is therefore considered atypical).
http://purl.obolibrary.org/obo/HP_0033621	Bronchial diverticula	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		Bronchial diverticula are blind-ended outpouchings arising from the bronchial tree. They are commonly pulsion diverticula acquired related to chronic cough. Subcarinal air cyst is thought to represent a small main bronchial diverticulum.
http://purl.obolibrary.org/obo/HP_0033622	Migratory erythematous plaque	http://purl.obolibrary.org/obo/HP_0010783	Erythema		A migratory, centrifugal, erythematous, tender, non-purpuric, and well-demarcated plaque. This feature may be observed in TNF receptor-associated periodic syndrome, in which it often occurs together with migratory myalgia in muscles located underneath the affected areas of skin.
http://purl.obolibrary.org/obo/HP_0033623	Birth history	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		Information about the delivery and health status at birth typically elicited as a part of the past medical history.
http://purl.obolibrary.org/obo/HP_0033624	History of congenital CMV infection	http://purl.obolibrary.org/obo/HP_0033623	Birth history		A congenital cytomegalovirus (CMV) infection of the newborn can follow either a primary or recurrent maternal infection. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. Affected infants may develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits.
http://purl.obolibrary.org/obo/HP_0033625	Emotional insecurity	http://purl.obolibrary.org/obo/HP_0020007	Abnormal affect regulation		A feeling of general unease or nervousness that may be triggered by a sense of vulnerability or instability, which is perceived as threatening.
http://purl.obolibrary.org/obo/HP_0033626	Increased non-HDL cholesterol concentration	http://purl.obolibrary.org/obo/HP_0003107	Abnormal circulating cholesterol concentration		Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol).
http://purl.obolibrary.org/obo/HP_0033627	Increased urine harderoporphyrin level	http://purl.obolibrary.org/obo/HP_0010473	Porphyrinuria		Concentration of harderoporphyrin in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033628	Bowel irritability	http://purl.obolibrary.org/obo/HP_0011458	Abdominal symptom		Intermittent abdominal pain with diarrhea and/or constipation.
http://purl.obolibrary.org/obo/HP_0033629	IgG4 autoimmune antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of an antibody of subclass IgG4 in the blood circulation that is directed against the organism's own cells or tissues.
http://purl.obolibrary.org/obo/HP_0033630	Brain fog	http://purl.obolibrary.org/obo/HP_0100543	Cognitive impairment		Brain fog is a type of transient cognitive dysfunction that comprises a constellation of symptoms that impair intellectual functioning to a level that interferes with daily activities, commonly including forgetfulness, mental slowness, difficulty thinking or focusing, a perceived slowing of mental processing speed, inability to find the right words, a sensation that the mind went blank or is "cloudy". Brain fog tends to recur and may be triggered by factors such as physical fatigue, lack of sleep, and prolonged standing or may appear to occur spontaneously.
http://purl.obolibrary.org/obo/HP_0033631	Spondylitis	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		Inflammation of the vertebrae (vertebral bodies) or spine.
http://purl.obolibrary.org/obo/HP_0033632	Abnormal alveolar volume	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		Alveolar volume (VA) is a volume accessible during 10-second breath-hold, measured during a single breath maneuver. VA is calculated by knowing the fractional concentration of the tracer gas (eg helium) and the volume of the gas inhaled. VA = Vi*(Fi tracer/Fa tracer). In this equation, Vi = inspired volume of tracer gas, Fi tracer= inspired fraction of tracer gas, Fa tracer = alveolar (exhaled) fraction of tracer gas.
http://purl.obolibrary.org/obo/HP_0033633	Decreased alveolar volume	http://purl.obolibrary.org/obo/HP_0033632	Abnormal alveolar volume		An abnormal reduction in alveolar volume.
http://purl.obolibrary.org/obo/HP_0033634	Increased alveolar volume	http://purl.obolibrary.org/obo/HP_0033632	Abnormal alveolar volume		An abnormal elevation in alveolar volume.
http://purl.obolibrary.org/obo/HP_0033635	Post-capillary pulmonary hypertension	http://purl.obolibrary.org/obo/HP_0004890	Elevated pulmonary artery pressure		Post-capillary pulmonary hypertension is a hemodynamic condition characterized by elevated mean pulmonary artery pressure (mPAP greater than 20 mmHg) and pulmonary artery wedge pressure (PAWP greater than 15 mmHg) and pulmonary vascular resistance (PVR less than 3 Wood units).
http://purl.obolibrary.org/obo/HP_0033636	Combined pre- and post-capillary pulmonary hypertension	http://purl.obolibrary.org/obo/HP_0004890	Elevated pulmonary artery pressure		Combined pre- and post-capillary pulmonary hypertension is a haemodynamic condition characterized by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary artery wedge pressure (PAWP over 15 mmHg) and pulmonary vascular resistance (PVR at least 3 Wodd units).
http://purl.obolibrary.org/obo/HP_0033637	Anti-endomysial antibody positivity	http://purl.obolibrary.org/obo/HP_0033563	Anti-tissue transglutaminase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endomysial tissue transglutaminase 2 (tTG2).
http://purl.obolibrary.org/obo/HP_0033638	Intralobular septal thickening	http://purl.obolibrary.org/obo/HP_0033711	Pulmonary interstitial thickening		Intralobular septal thickening is a computed tomography finding of increased width of the walls (septa) within a pulmonary lobule. Secondary pulmonary lobules represent a cluster of up to 30 acini 9 supplied by a common distal pulmonary artery and bronchiole. These clustered acini are bounded by interstitial fibrous septa (interlobular septa) which outline an irregular polyhedron of varying size between 1 and 2.5 cm. Interlobular septal thickening is seen on chest radiographs as thin linear opacities at right angles to and in contact with the lateral pleural surfaces near the lung bases. In contrast, intralobular septal thickening are visible as fine linear opacities in a lobule when the intralobular interstitial tissue is abnormally thickened. When numerous, they may appear as a fine reticular pattern.
http://purl.obolibrary.org/obo/HP_0033639	Septic pulmonary embolism	http://purl.obolibrary.org/obo/HP_0033553	Septic embolism		Embolization of intravascular thrombus containing microorganisms into the pulmonary parenchyma via arterial system. Septic pulmonary embolism (PE) can be associated with multiple additional clinical manifestations such as fever, tachypnea, and hemoptysis. This HPO term refers to the finding of the septic embolus in the lung, which can be inferred from radiological findings. Typical radiographic features of septic PE include patchy air space lesions simulating non-specific bronchopneumonia; multiple ill defined round or wedge shaped densities of varying sizes from approximately 0.5 to 3.5 cm located peripherally; lesions abutting the pleura and located at the end of vessels (feeding vessel sign) seen on chest CT scans. Other pulmonary features suggesting septic PE include bilateral, occasional unilateral, rapid progression of cavities or abscess formations.
http://purl.obolibrary.org/obo/HP_0033641	Aortic valve leaflet calcification	http://purl.obolibrary.org/obo/HP_0004380	Aortic valve calcification		Deposition of calcium salts in the leaflets (cusps) of the aortic valve.
http://purl.obolibrary.org/obo/HP_0033642	Mitral valve leaflet calcification	http://purl.obolibrary.org/obo/HP_0004382	Mitral valve calcification		Deposition of calcium salts in the leaflets (cusps) of the mitral valve.
http://purl.obolibrary.org/obo/UBERON_8410024	intestinal junction	http://purl.obolibrary.org/obo/UBERON_1100000	digestive tract junction		An anatomical junction between two parts of the intestine.
http://purl.obolibrary.org/obo/UBERON_1100000	digestive tract junction	http://purl.obolibrary.org/obo/UBERON_0007651	anatomical junction		An anatomical junction between two parts of the digestive tract.
http://purl.obolibrary.org/obo/CL_0009052	smooth muscle cell of anorectum	http://purl.obolibrary.org/obo/CL_1000279	smooth muscle cell of large intestine		A smooth muscle cell that is located in the anorectum.
http://purl.obolibrary.org/obo/CL_0009061	intestinal crypt stem cell of anorectum	http://purl.obolibrary.org/obo/CL_0009016	intestinal crypt stem cell of large intestine		An intestinal crypt stem cell that is located in the anorectum.
http://purl.obolibrary.org/obo/UBERON_8480024	skin of sacral region	http://purl.obolibrary.org/obo/UBERON_0001415	skin of pelvis		A zone of skin that is part of the sacral region.
http://purl.obolibrary.org/obo/CL_4030034	respiratory tract multiciliated cell	http://purl.obolibrary.org/obo/CL_0005012	multiciliated epithelial cell		A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis.
http://purl.obolibrary.org/obo/CL_4030035	dental pulp stem cell	http://purl.obolibrary.org/obo/CL_0002148	dental pulp cell		A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation.
http://purl.obolibrary.org/obo/CL_4033005	serous secreting cell of bronchus submucosal gland	http://purl.obolibrary.org/obo/CL_0019001	tracheobronchial serous cell		A(n) serous secreting cell that is part of a(n) bronchus submucosal gland.
http://purl.obolibrary.org/obo/CL_4033008	vein endothelial cell of respiratory system	http://purl.obolibrary.org/obo/CL_0002543	vein endothelial cell		A(n) vein endothelial cell that is part of a(n) respiratory system.
http://purl.obolibrary.org/obo/CL_4033037	mucus secreting cell of tracheobronchial tree submucosal gland	http://purl.obolibrary.org/obo/CL_0008055	respiratory tract secretory epithelial cell		A mucus secreting cell of a submucosal gland of the tracheobronchial tree.
http://purl.obolibrary.org/obo/HP_0034761	Neurofibroma by anatomical location	http://purl.obolibrary.org/obo/HP_0001067	Neurofibroma		Neurofibroma categorized according to the anatomical site of origin.
http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		The amount of an organic compound in the urine, normalized for urine concentration, is outside the limits of normal. An organic compound is defined here as a chemical compound that contains a carbon-hydrogen or carbon-carbon bond, although some other definitions exist. Examples of organic compounds includes alkanes, alkenes, alkynes, aromatic compounds, alcohols, ketones, aldehydes, carboxylic acids, and esters.
http://purl.obolibrary.org/obo/GO_0140392	extracellular protein-containing complex	http://purl.obolibrary.org/obo/GO_0032991	protein-containing complex		A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together outside a cell.
http://purl.obolibrary.org/obo/UBERON_0000001	gross anatomical part	http://purl.obolibrary.org/obo/UBERON_0000465	material anatomical entity		Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell.  Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells.
http://purl.obolibrary.org/obo/PATO_0045021	normal flexibility	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A flexibility which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045081	normal viscosity	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A viscosity which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045061	normal width	http://purl.obolibrary.org/obo/PATO_0045050	normal size		A width which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045064	normal strength	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A strength which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045053	normal height	http://purl.obolibrary.org/obo/PATO_0045050	normal size		A height which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045084	normal duration	http://purl.obolibrary.org/obo/PATO_0045073	normal process quality		A duration quality of a process which is relatively normal.
http://purl.obolibrary.org/obo/CHEBI_139589	retinoid anion	http://purl.obolibrary.org/obo/CHEBI_29067	carboxylic acid anion		A carboxylic acid anion obtained by deprotonation of any retinoid carboxy group.
http://purl.obolibrary.org/obo/GO_0062033	positive regulation of mitotic sister chromatid segregation	http://purl.obolibrary.org/obo/GO_0033047	regulation of mitotic sister chromatid segregation		Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.
http://purl.obolibrary.org/obo/HP_0032544	Predominant small joint localization	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applies to an abnormality that mainly affects the small joints, including fingers, toes, interphalangeal, metacarpophalangeal, metatarsophalangeal, wrists, ankles, vertebrae, and neck.
http://purl.obolibrary.org/obo/HP_0032545	Abdominal rigidity	http://purl.obolibrary.org/obo/HP_0002027	Abdominal pain		Involuntary tightening of the abdominal musculature that occurs in response to touching the abdomen to avoid pain. Rigidity can occur in the presence of abdominal inflammation and usually involves only the inflamed area.
http://purl.obolibrary.org/obo/HP_0032546	Abdominal guarding	http://purl.obolibrary.org/obo/HP_0002027	Abdominal pain		A voluntary contraction of the abdominal wall musculature to avoid pain.
http://purl.obolibrary.org/obo/HP_0032547	Low intraocular pressure	http://purl.obolibrary.org/obo/HP_0012632	Abnormal intraocular pressure		An abnormal decrease of the pressure within the eye.
http://purl.obolibrary.org/obo/HP_0032548	Increased placental thickness	http://purl.obolibrary.org/obo/HP_0012767	Abnormal placental size		Abnormally elevated placental thickness.
http://purl.obolibrary.org/obo/HP_0032549	Persistent asymmetrical tonic neck reflex	http://purl.obolibrary.org/obo/HP_0002476	Primitive reflex		Persistence beyond the normal age (roughly the first half of the first year of life) of the asymmetric tonic neck reflex (ATNR), which is an easily elicited primitive reflex in the immediate newborn period. The ATNR refers to the phenomenon whereby when the face of an infant is turned to one side, the ipsilateral arm and leg extend and the contralateral arm and leg flex. This posture has been compared to a typical posture of fencers.
http://purl.obolibrary.org/obo/HP_0032550	Howell-Jolly bodies	http://purl.obolibrary.org/obo/HP_0020080	Erythrocyte inclusion bodies		Howell-Jolly bodies are small, intra-erythrocytic remnants of erythrocyte nuclei. These inclusions are solitary in each erythrocyte and strongly basophilic. These are often confused with overlying platelets, but can be distinguished by the presence of a halo around overlying platelets.
http://purl.obolibrary.org/obo/HP_0032551	Hemorrhoids	http://purl.obolibrary.org/obo/HP_0002034	Abnormal rectum morphology		Enlarged, bulging blood vessels in and around the anus often associated with rectal bleeding, itching, and pain.
http://purl.obolibrary.org/obo/HP_0032552	Abnormal pulse	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		An anomaly of the rhythmic throbbing of an artery that reflects the widening of the artery as blood flows through it and is caused by successive contractions of the heart.
http://purl.obolibrary.org/obo/HP_0032553	Weak pulse	http://purl.obolibrary.org/obo/HP_0032552	Abnormal pulse		A diminution in the amplitude (strength) of the pulse such that the examiner has difficulty feeling the pulse.
http://purl.obolibrary.org/obo/HP_0032554	Absent pulse	http://purl.obolibrary.org/obo/HP_0032552	Abnormal pulse		The pulsation of an artery where the pulse is taken (e.g. the radial artery at the wrist) cannot be detected on physical examination.
http://purl.obolibrary.org/obo/HP_0032555	Bounding pulse	http://purl.obolibrary.org/obo/HP_0032552	Abnormal pulse		Increased amplitude (strength) of the pulse.
http://purl.obolibrary.org/obo/HP_0032556	Circumoral cyanosis	http://purl.obolibrary.org/obo/HP_0034031	Facial cyanosis		Persistent blue color of the skin that surrounds the mouth.
http://purl.obolibrary.org/obo/HP_0032557	History of bone marrow transplant	http://purl.obolibrary.org/obo/HP_0430103	Past surgical history		A past medical history of hematopoietic stem cell transplantation involving myeloablative chemoradiotherapy followed by stem cell rescue with autologous or human leukocyte antigen (HLA)-matched stem cells derived from a donor.
http://purl.obolibrary.org/obo/HP_0032558	Absent sperm flagella	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		Sperm cells lacking flagella.
http://purl.obolibrary.org/obo/HP_0032559	Short sperm flagella	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		Sperm cells with abnormally short flagella.
http://purl.obolibrary.org/obo/HP_0032560	Coiled sperm flagella	http://purl.obolibrary.org/obo/HP_0012868	Abnormal sperm tail morphology		Sperm cells whose flagella are twisted (coiled).
http://purl.obolibrary.org/obo/HP_0032561	Microcephalic sperm head	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Decreased size of the head of sperm.
http://purl.obolibrary.org/obo/HP_0032562	Tapered sperm head	http://purl.obolibrary.org/obo/HP_0012865	Abnormal sperm head morphology		Sperm with cigar-shaped heads that gradually dimish in diameter (taper).
http://purl.obolibrary.org/obo/HP_0032563	Dacryocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		Presence of teardrop-shaped red blood cells.
http://purl.obolibrary.org/obo/CL_3000004	peripheral sensory neuron	http://purl.obolibrary.org/obo/CL_2000032	peripheral nervous system neuron		A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing.
http://purl.obolibrary.org/obo/HP_0025643	Tarlov cyst	http://purl.obolibrary.org/obo/HP_0030724	Central nervous system cyst		A cerebrospinal fluid-filled nerve root cyst most often localized in the sacral spine.
http://purl.obolibrary.org/obo/HP_0032564	Ileitis	http://purl.obolibrary.org/obo/HP_0001549	Abnormal ileum morphology		Inflammation of the ileum.
http://purl.obolibrary.org/obo/HP_0032566	Oval macrocytosis	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		Enlarged, oval-shaped erythrocytes (red blood cells).
http://purl.obolibrary.org/obo/HP_0032567	Lipiduria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		An increased lipid content in the urine.
http://purl.obolibrary.org/obo/HP_0032568	Urinary mulberry cells	http://purl.obolibrary.org/obo/HP_0012614	Abnormal urine cytology		Distal tubular epithelial cells in which globotriaosylceramide (Gb3) has accumulated. they are the characteristic feature of Fabry disease. Urinary mulberry bodies are a component of mulberry cells that can be distinguished easily from fat particles by their inner lamellar appearance.
http://purl.obolibrary.org/obo/HP_0032569	Temporal bossing	http://purl.obolibrary.org/obo/HP_0009911	Abnormal temporal bone morphology		Prominence (bulging) in the temple region, which is the part of the skull where the frontal, parietal, temporal, and sphenoid bones join on the side of the head.
http://purl.obolibrary.org/obo/HP_0041042	Absent neutrophil lactoferrin	http://purl.obolibrary.org/obo/HP_0012551	Absent neutrophil specific granules		The absence of lactoferrin in neutrophil granules, which could be caused by either an isolated failure of synthesis of this protein (or the production of an antigenically unrecognizable form of lactoferrin) or a complete deficiency of specific granule production.
http://purl.obolibrary.org/obo/HP_0041043	Neutrophil nuclear clefts	http://purl.obolibrary.org/obo/HP_0410310	Abnormality of neutrophil morphology in CSF		An abnormality of the nucleus of neutrophils, which presents as either a type I nuclear cleft, where the nuclear cleft may show a transition into a round/oval shape. The second type nuclear cleft, which runs perpendicular to the nuclear surface, and this type of cleft might be related to nuclear lobe formation.
http://purl.obolibrary.org/obo/HP_0041044	Low neutrophil alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003282	Decreased circulating alkaline phosphatase activity		An abnormally reduced level of alkaline phosphatase in neutrophils, which could be due to absence of enzyme or the production of defective enzyme.
http://purl.obolibrary.org/obo/HP_0041045	Increased neutrophil mitochondria	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		An increased number of mitochondria detected in neutrophils.
http://purl.obolibrary.org/obo/HP_0041046	Increased neutrophil ribosomes	http://purl.obolibrary.org/obo/HP_0011992	Abnormal neutrophil morphology		An increased number of ribosomes detected in neutrophils.
http://purl.obolibrary.org/obo/HP_0041047	Bladder outlet obstruction	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		A compression or resistance upon the bladder outflow channel at any location from the bladder neck to urethral meatus, which usually causes lower urinary tract symptoms (LUTS).
http://purl.obolibrary.org/obo/HP_0041048	Decreased expression of GPI-anchored proteins on the cell surface	http://purl.obolibrary.org/obo/HP_0031551	Reduced cell surface marker level		A decrease in the protein expression of GPI-anchor proteins, such as CD55 and CD59, at the cell surface, which suggests a defect in GPI-anchor biosynthesis.
http://purl.obolibrary.org/obo/HP_0045088	Clinical relevance	http://purl.obolibrary.org/obo/HP_0012823	Clinical modifier		Subontology for annotating phenotypic features as distinctive or minor findings in patients. The subontology is intended to be used to annotate subjective clinical impressions of whether a certain finding is important for the differential diagnosis.
http://purl.obolibrary.org/obo/HP_0045089	Distinctive finding	http://purl.obolibrary.org/obo/HP_0045088	Clinical relevance		In clinical parlance, findings are occasionally interpreted as being distinctive or minor, reflecting a subjective clinical impression of the importance of a feature for the differential diagnosis. A minor finding is taken to be one that is likely to have high utility in distinguishing the correct diagnosis from other candidates in the differential.
http://purl.obolibrary.org/obo/HP_0045090	Minor finding	http://purl.obolibrary.org/obo/HP_0045088	Clinical relevance		In clinical parlance, findings are occasionally interpreted as being distinctive or minor, reflecting a subjective clinical impression of the importance of a feature for the differential diagnosis. A minor finding is taken to be one that is unlikely to help distinguish the correct diagnosis from other candidates in the differential.
http://purl.obolibrary.org/obo/HP_0410362	Decreased O-mannosyl glycans on alpha-dystroglycan	http://purl.obolibrary.org/obo/HP_0012358	Abnormal protein O-linked glycosylation		Hypoglycosylation of alpha-dystroglycan with O-mannosyl glycans. Alpha-dystroglycan is a functional target of O-mannosyl glycosylation and functional glycosylation of alpha-DG is essential in its interaction with the extracellular matrix.
http://purl.obolibrary.org/obo/HP_0410367	Increased hepatitis A virus antibody level	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		An abnormally increased level of immunoglobulin against hepatitis A virus in the blood.
http://purl.obolibrary.org/obo/HP_0410369	Increased hepatitis B virus antibody level	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		An abnormally increased level of immunoglobulin against hepatitis B virus in the blood.
http://purl.obolibrary.org/obo/HP_0410371	Increased hepatitis C virus antibody level	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		An abnormally increased level of immunoglobulin against hepatitis C virus in the blood.
http://purl.obolibrary.org/obo/HP_0500262	Atrichia	http://purl.obolibrary.org/obo/HP_0011362	Abnormal hair quantity		The most dramatic and severe form of hair loss characterized by an absence of hair follicles.
http://purl.obolibrary.org/obo/UBERON_0037144	wall of heart	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees.
http://purl.obolibrary.org/obo/PATO_0010006	cell morphology	http://purl.obolibrary.org/obo/PATO_0000051	morphology		A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure.
http://purl.obolibrary.org/obo/PATO_0070010	stellate morphology	http://purl.obolibrary.org/obo/PATO_0070026	multipolar neuron morphology		A cell morphology that inheres in neurons that have dendritic processes radiating from the cell body forming a star-like shape.
http://purl.obolibrary.org/obo/CL_0009045	B cell of medullary sinus of lymph node	http://purl.obolibrary.org/obo/CL_0000236	B cell		A B cell found in the lymph node medullary sinus.
http://purl.obolibrary.org/obo/CL_0009084	glandular epithelial cell of endometrium	http://purl.obolibrary.org/obo/CL_0002149	epithelial cell of uterus		An epithelial cell that is part of an endometrium glandular epithelium.
http://purl.obolibrary.org/obo/CL_0009086	endothelial cell of respiratory system lymphatic vessel	http://purl.obolibrary.org/obo/CL_0002138	endothelial cell of lymphatic vessel		An endothelial cell that is part of a respiratory system lymphatic vessel.
http://purl.obolibrary.org/obo/CL_0009092	endothelial cell of placenta	http://purl.obolibrary.org/obo/CL_0000115	endothelial cell		An endothelial cell that is part of a placenta.
http://purl.obolibrary.org/obo/CL_0009093	smooth muscle cell of placenta	http://purl.obolibrary.org/obo/CL_0000192	smooth muscle cell		A smooth muscle cell that is part of a placenta.
http://purl.obolibrary.org/obo/CL_0009094	endothelial cell of hepatic portal vein	http://purl.obolibrary.org/obo/CL_0002543	vein endothelial cell		An endothelial cell that is part of a hepatic portal vein.
http://purl.obolibrary.org/obo/CL_0009095	endothelial cell of uterus	http://purl.obolibrary.org/obo/CL_0000115	endothelial cell		An endothelial cell that is part of a uterus.
http://purl.obolibrary.org/obo/CL_4030001	stromal cell of thymus	http://purl.obolibrary.org/obo/CL_0000499	stromal cell		A stromal cell that is part of the thymus.
http://purl.obolibrary.org/obo/HP_0025652	Abnormal placental adhesion into the uterine wall	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Abnormal placental adhesion is characterized by an anomalous adherence of the placenta to the uterine wall. Based on the degree of adhesion, placental invasion can be classified into accreta, increta, or percreta.
http://purl.obolibrary.org/obo/HP_0025653	Placenta percreta	http://purl.obolibrary.org/obo/HP_0025652	Abnormal placental adhesion into the uterine wall		Placenta percreta is a rare form of morbidly adherent placenta with penetration through the myometrium reaching serosa and even adjacent pelvic organs.
http://purl.obolibrary.org/obo/HP_0025654	Placenta accreta	http://purl.obolibrary.org/obo/HP_0025652	Abnormal placental adhesion into the uterine wall		Abnormally firm adherence of the placenta to the uterine wall.
http://purl.obolibrary.org/obo/HP_0025655	Placenta increta	http://purl.obolibrary.org/obo/HP_0025652	Abnormal placental adhesion into the uterine wall		Abnormal placental pentration into but not beyond the uterine wall.
http://purl.obolibrary.org/obo/HP_0025656	Prenatal double bubble sign	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Sonographic detection of a double bubble sign in the upper abdomen is strongly indicative of duodenal obstruction. One bubble represents fetal stomach, and the other is attributed to a dilated proximal part of the duodenum; continuity between both bubbles is required for the sign.
http://purl.obolibrary.org/obo/HP_0025659	Decreased circulating creatine kinase activity	http://purl.obolibrary.org/obo/HP_0040081	Abnormal circulating creatine kinase activity		The activity of creatine kinase in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0025660	Chiari type II malformation	http://purl.obolibrary.org/obo/HP_0002308	Chiari malformation		A type of Chiari malformation that consists of brainstem herniation and a towering cerebellum in addition to the herniated cerebellar tonsils and vermis due to an open distal spinal dysraphism/myelomeningocele.
http://purl.obolibrary.org/obo/HP_0025661	Chiari type III malformation	http://purl.obolibrary.org/obo/HP_0002308	Chiari malformation		A type of Chiari malformation that involves herniation of the hindbrain (cerebellum with or without the brainstem) into a low occipital or high cervical meningoencephalocele.
http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		An anomalous structural finding of the fetal skeleton. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other terms from the skeletal hierarchy can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0025663	Reduced fetal femur/foot length ratio	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		This ratio relates the length of the fetal femur to that of the fetal foot. The ratio is approximately 1 throughout the age range of 14 to 40 weeks of gestation. A substantial reduction in the raio can help differentiate fetuses that have dysplastic limb reduction from those whose limbs are short because of constitutional factors or IUGR. It can reduce the problem of an unknown gestational age and help to distinguish between fetal skeletal dysplasia and intrauterine growth retardation caused by other factors.
http://purl.obolibrary.org/obo/HP_0025664	Moderate to late preterm birth	http://purl.obolibrary.org/obo/HP_0001622	Premature birth		Birth at 32 to 36 completed weeks of gestation.
http://purl.obolibrary.org/obo/HP_0025665	Extremely preterm birth	http://purl.obolibrary.org/obo/HP_0001622	Premature birth		Birth before 28 completed weeks of gestation (up to and including 27 weeks and 6 days of gestation).
http://purl.obolibrary.org/obo/HP_0025666	Very preterm birth	http://purl.obolibrary.org/obo/HP_0001622	Premature birth		Birth before 32 completed weeks of gestation (28 up to but not including 32 weeks).
http://purl.obolibrary.org/obo/HP_0025670	Syntelencephaly	http://purl.obolibrary.org/obo/HP_0001360	Holoprosencephaly		Syntelencephaly is a rare malformation that consists of an abnormal midline connection of the cerebral hemispheres in the posterior frontal and parietal regions, with interhemispheric separation of the basal forebrain, anterior frontal lobes, and occipital regions.
http://purl.obolibrary.org/obo/HP_0025671	Fetal pericardial effusion	http://purl.obolibrary.org/obo/HP_0010948	Abnormal fetal cardiovascular morphology		An abnormal accumulation of fluid in which the heart is partially or completely surrounded by fluid that is seen in all views and the thickness of the fluid as observed by prenatal ultrasound is above age-dependent norms.
http://purl.obolibrary.org/obo/HP_0025672	Fetal skin edema	http://purl.obolibrary.org/obo/HP_0025723	Abnormal fetal skin morphology		A separation of skin in one or more regions of the body or even along the entire length of body wall (to a degree greater than gestational-age related norms) related to pathologically increased fluid accumulation in the subcutaneous tissue.
http://purl.obolibrary.org/obo/HP_0025673	Loculated ascites	http://purl.obolibrary.org/obo/HP_0001541	Ascites		A type of ascites (peritoneal fluid collection) that is divided into loculi (compartments) by septa (fibrous walls). Ascites fluid can become loculated when confined by adhesions, malignancy or infection.
http://purl.obolibrary.org/obo/HP_0025674	Meconium pseudocyst	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		A meconium-containing cyst in the peritoneal space . Meconium pseudocysts form in the presence of meconium peritonitis, which is defined as a sterile peritonitis caused by escape of meconium from the intestinal tract into the general peritoneal cavity during the fetal or perinatal period. When the extruded meconium becomes walled off, it can form a rim-calcified mass representing the meconium pseudocyst.
http://purl.obolibrary.org/obo/HP_0025675	Premature closure of the ductus arteriosus	http://purl.obolibrary.org/obo/HP_0034190	Abnormal fetal cardiovascular physiology		A prenatal partial or complete closure of the ductus arteriosus (i.e., prior to delivery).
http://purl.obolibrary.org/obo/HP_0025676	Fetal pleural effusion	http://purl.obolibrary.org/obo/HP_0034243	Abnormal fetal pulmonary morphology		Fetal pleural effusion is the accumulation of excess fluid in the layers of tissue (pleura) lining the lungs and wall of the chest. It may be primary, also termed hydrothorax, occurring as an isolated finding or it may be secondary, most commonly resulting from non-immune hydrops.
http://purl.obolibrary.org/obo/HP_0025677	Fetal chylothorax	http://purl.obolibrary.org/obo/HP_0025676	Fetal pleural effusion		The presence of chyle (a type of lipid-rich lymph) in the pleural space (the space surrounding the lung) as observed in a fetus.
http://purl.obolibrary.org/obo/HP_0025678	Fetal hydrothorax	http://purl.obolibrary.org/obo/HP_0025676	Fetal pleural effusion		Accumulation of lymphatic fluid in the pleural space. This finding is usually observed by prenatal sonography. Once neonatal feeding is established and the lymphatic fluid contains chyle, transformation to chylothorax may be observed.
http://purl.obolibrary.org/obo/HP_0025679	Diskitis	http://purl.obolibrary.org/obo/HP_0005108	Abnormal intervertebral disk morphology		Inflammation of an intervertebral disk or disk space.
http://purl.obolibrary.org/obo/HP_0025680	Compound muscle action potential amplitude facilitation	http://purl.obolibrary.org/obo/HP_0030179	Abnormal peripheral action potential amplitude		Compound muscle action potential amplitude (CMAP) facilitation denotes an increase in tendon reflexes, strength, or CMAP amplitude after 10 seconds of maximal voluntary contraction.
http://purl.obolibrary.org/obo/HP_0025681	Distal clavicular thinning	http://purl.obolibrary.org/obo/HP_0006645	Thin clavicle		Abnormally reduced diameter (cross section) of the clavicles that is limited to the distal region.
http://purl.obolibrary.org/obo/HP_0025682	Crouch gait	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		A gait disturbance that is characterized by excessive ankle dorsiflexion, knee and hip flexion during the stance phase.
http://purl.obolibrary.org/obo/HP_0025683	Abnormal amyloid beta 42 peptide CSF concentration	http://purl.obolibrary.org/obo/HP_0025688	Abnormal amyloid beta peptide CSF concentration		Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta42, which is 42 amino acids in length, is the longer form.
http://purl.obolibrary.org/obo/HP_0025684	Decreased amyloid beta 42 peptide CSF concentration	http://purl.obolibrary.org/obo/HP_0025683	Abnormal amyloid beta 42 peptide CSF concentration		A reduction from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0025685	Increased amyloid beta 42 peptide CSF concentration	http://purl.obolibrary.org/obo/HP_0025683	Abnormal amyloid beta 42 peptide CSF concentration		An elevation above the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0025686	Abnormal amyloid beta 40 peptide CSF concentration	http://purl.obolibrary.org/obo/HP_0025688	Abnormal amyloid beta peptide CSF concentration		Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta40, which is 40 amino acids in length, is the shorter form.
http://purl.obolibrary.org/obo/HP_0025687	Increased amyloid beta 40 peptide CSF concentration	http://purl.obolibrary.org/obo/HP_0025686	Abnormal amyloid beta 40 peptide CSF concentration		An elevation above the normal concentration of amyloid beta 40 peptide in the cerebrospinal fluid (CSF).
http://purl.obolibrary.org/obo/HP_0025688	Abnormal amyloid beta peptide CSF concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		Any anomaly in the concentration of a cleaved APP amyloid beta protein fragment in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0025689	Extra-abdominal umbilical vein varix	http://purl.obolibrary.org/obo/HP_0030656	Umbilical vein varix		Focal dilatation of the extra-abdominal portion of the umbilical vein. An extra-abdominal umbilical varix is difficult to diagnose prenatally as it can appear like a cyst on ultrasound prior to birth.
http://purl.obolibrary.org/obo/HP_0025690	Fetal intra-abdominal umbilical vein varix	http://purl.obolibrary.org/obo/HP_0030656	Umbilical vein varix		Fetal intra-abdominal umbilical vein varix (FIUVV) is defined by the focal dilatation of the fetal umbilical vein between its entry in the abdomen and its ending in the portal system. The dilatation can be defined using one of the following criteria: a portion of intra-abdominal umbilical vein that is at least 50% wider than the non-dilated portion; a dilatation of 9 mm or more, or a dilatation greater than 2 SD above the mean value for gestational age.
http://purl.obolibrary.org/obo/HP_0025691	Impaired fasting glucose	http://purl.obolibrary.org/obo/HP_0003074	Hyperglycemia		Impaired fasting glucose (IFG) is indicated by a fasting plasma glucose above normal but below the diabetic range. Levels between 110 mg/dl (6.1 mmol/l) to 125 mg/dl (6.9 mmol/l) are diagnostic of IFG.
http://purl.obolibrary.org/obo/HP_0025692	Atelencephaly	http://purl.obolibrary.org/obo/HP_0007364	Aplasia/Hypoplasia of the cerebrum		A defect of development of the brain characterized by absence of the telencephalon (embryonic structure from which the mature cerebrum develops).
http://purl.obolibrary.org/obo/HP_0025693	Pituitary macroadenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A pituitary gland adenoma that is larger than 10mm.
http://purl.obolibrary.org/obo/HP_0025694	Pituitary microadenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		A pituitary adenoma that is less than 10 mm in diameter.
http://purl.obolibrary.org/obo/HP_0025695	Mucus plug	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		Mucus that is abnormally thick in consistency (ie, inspissated) and plugs the airway is known as a mucus plug. Mucus plugs consist of mucins and cells and can partially or completely obstruct one or more airways and cause serious consequences, including atelectasis and recurrent infection.
http://purl.obolibrary.org/obo/HP_0025696	Airway casts	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		A replicate of airways from accumulated and condensed mucous and cellular material. These semisolid occlusions take the shape of the airway within they are formed, leading to obstruction of the tracheobronchial tree with consecutive respiratory insufficiency. Based on their principal composition, one can differentiate fibrin casts and mucin casts. Plastic bronchitis is the name of the condition characterized by the formation of airway casts.
http://purl.obolibrary.org/obo/HP_0025697	Fibrin casts	http://purl.obolibrary.org/obo/HP_0025696	Airway casts		A type of airway casts that consist of plasma components and inflammatory cells.
http://purl.obolibrary.org/obo/HP_0025698	Mucin casts	http://purl.obolibrary.org/obo/HP_0025696	Airway casts		A type of airway casts that consist of impacted mucus.
http://purl.obolibrary.org/obo/HP_0025699	Perisylvian FDG hypermetabolism	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (FDG-PET/CT) evaluates the glucose metabolism of the brain. FDG uptake is interpreted to represent glycolysis. This term therefore represents an abnormally increased FDG uptake (increased glucose metabolism) in the region of the brain that surrounds the Sylvian fissure.
http://purl.obolibrary.org/obo/HP_0025700	Anhydramnios	http://purl.obolibrary.org/obo/HP_0001560	Abnormality of the amniotic fluid		A complete or near-complete lack of amniotic fluid surrounding a fetus. This finding can be observed sonographically in the third trimesters if the deepest pocket of amniotic fluid is less than or equal to 2 cm.
http://purl.obolibrary.org/obo/HP_0025701	Distended jugular lymphatic sacs	http://purl.obolibrary.org/obo/HP_0025667	Fetal neck anomaly		The jugular lymphatic sacs (JLS) are a physiological and temporary part of fetal lymphatic development. They are formed from small buds of lymphatic endothelial cells arising from the internal jugular veins. By 14 weeks gestation they have developed into lymphatic nodes which drain into the systemic circulation. Visibility of JLS on ultrasound past 14 weeks of gestation implies distension and this may be associated with raised nuchal translucency.
http://purl.obolibrary.org/obo/HP_0025702	Type 1 schizencephaly	http://purl.obolibrary.org/obo/HP_0010636	Schizencephaly		A type of Schizencephaly in which there is a trans-mantle column of abnormal gray matter but no evidence of a CSF-containing cleft on MR imaging.
http://purl.obolibrary.org/obo/HP_0025703	Type 2 schizencephaly	http://purl.obolibrary.org/obo/HP_0010636	Schizencephaly		A type of Schizencephaly in which CSF-containing cleft is present with abutting lining lips of abnormal gray matter that are opposed to each other.
http://purl.obolibrary.org/obo/HP_0025704	Type 3 schizencephaly	http://purl.obolibrary.org/obo/HP_0010636	Schizencephaly		A type of Schizencephaly in which CSF-containing cleft present with non-abutting lining lips of abnormal gray matter.
http://purl.obolibrary.org/obo/HP_0025705	Abnormal fetal nasal bone visualization	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		Abnormal appearance or non-visualization (apparent absence) of the nasal bone of a fetus in first trimester sonographic screening. Assessment of the fetal nasal bone is generally performed at 11-14 weeks gestational age.
http://purl.obolibrary.org/obo/HP_0025706	Absent fetal nasal bone	http://purl.obolibrary.org/obo/HP_0025705	Abnormal fetal nasal bone visualization		The nasal bone is considered absent when it is not visualized on a midsagittal view of the profile. In the second trimester, a true midsagittal view of the fetal profile is obtained and magnified to fill the majority of the image space. The nasal bone appears as an echogenic linear structure below the skin edge. The optimal angle of insonation is 45 degrees to the longitudinal axis of the fetal nasal bone. If the angle of insonation is 0 or 180 degrees, the nasal bone may appear artificially absent. The presence or absence of the nasal bone may be determined at the time of the 11- to 14-week ultrasound examination and used as part of the risk assessment for aneuploidy.
http://purl.obolibrary.org/obo/HP_0025707	Hypoplastic fetal nasal bone	http://purl.obolibrary.org/obo/HP_0025705	Abnormal fetal nasal bone visualization		Length of the nasal bone below a predetermined cut-off as seen on antenatal ultrasound using standard imaging techniques.
http://purl.obolibrary.org/obo/HP_0025708	Early young adult onset	http://purl.obolibrary.org/obo/HP_0011462	Young adult onset		Onset of disease at an age of greater than or equal to 16 to under 19 years.
http://purl.obolibrary.org/obo/HP_0025709	Intermediate young adult onset	http://purl.obolibrary.org/obo/HP_0011462	Young adult onset		Onset of disease at an age of greater than or equal to 19 to under 25 years.
http://purl.obolibrary.org/obo/HP_0025710	Late young adult onset	http://purl.obolibrary.org/obo/HP_0011462	Young adult onset		Onset of disease at an age of greater than or equal to 25 to under 40 years.
http://purl.obolibrary.org/obo/HP_0025711	Convergence-retraction nystagmus	http://purl.obolibrary.org/obo/HP_0000639	Nystagmus		Convergence-retraction nystagmus is an irregular, jerky nystagmus in which both eyeballs rhythmically converge and retract into the orbit, particularly on attempting an upward gaze.
http://purl.obolibrary.org/obo/HP_0025712	Spontaneous chorioamniotic separation	http://purl.obolibrary.org/obo/HP_0011409	Abnormal placental membrane morphology		Persistence separation of the chorionic and amnionic membranes after the 16th week of gestation (not as a result of a procedure such as amniocentesis).
http://purl.obolibrary.org/obo/HP_0025713	Neurite dystrophy	http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology		Dystrophic neurites are abnormal neuronal processes characterized microscopically by aberrant sprouting, dystrophic expansion, and accumulation of various cellular organelles and cytoskeletal/signaling proteins.
http://purl.obolibrary.org/obo/HP_0025714	Cerebral cortical microinfarct	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		An infarct located on the outer layer of the cerebrum that can only be observed microscopically. Cerebral microinfarcts are typically defined as sharply delimited microscopic regions of cellular death or tissue necrosis, sometimes with cavitation (that is, a central fluid-filled cavity). The term microscopic denotes that these lesions are not visible by gross inspection of the brain but seen by light microscopy. The term infarct is most commonly used for ischemia-related tissue loss, and indeed the pathologic appearance of microinfarcts is consistent with that of known ischemic infarctions.
http://purl.obolibrary.org/obo/HP_0025715	Abnormal umbilical artery doppler waveform during pregnancy	http://purl.obolibrary.org/obo/HP_0025657	Abnormal umbilical blood flow measurement		Abnormal waveforms the Doppler sonographic examination of bloodflow in the umbilical artery. vUmbilical arterial Doppler assessment is used in surveillance of fetal health in the third trimester.
http://purl.obolibrary.org/obo/HP_0025716	Fetal anemia	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		Low hemoglobin/hematocrit in a fetus as evidenced by percutaneous umbilical cord sampling and Doppler ultrasonographic assessment of the peak velocity of systolic blood flow in the middle cerebral artery.
http://purl.obolibrary.org/obo/HP_0025717	Skeletal muscle autophagosome accumulation	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Abnormal accumulation of autophagosomes in skeletal muscle tissue.
http://purl.obolibrary.org/obo/HP_0025718	Skeletal muscle hyperechogenicity	http://purl.obolibrary.org/obo/HP_0011805	Abnormal skeletal muscle morphology		An increased echo intensity of muscle tissue on sonography, defined as an increased amount of returning echoes per square area of muscle tissue. On cross-section, normal muscle appears as a relatively anechoic structure with hyperechoic speckles within the tissue representing perimysial septa, giving it a starry night appearance. The boundaries of each muscle are delineated by the presence of hyperechoic fascia. In muscle disorders, one of the hallmark findings is replacement of healthy muscle with fat and fibrosis, manifested by an increase in echogenicity from higher sound transitions in the muscle. This increase in echogenicity is most distinct in conditions that lead to chronic pathology, such as long-standing muscle inflammation, dystrophy, or denervation.
http://purl.obolibrary.org/obo/HP_0025719	Maternal vascular malperfusion	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		Gross findings of maternal vascular malperfusion include placental hypoplasia, placental infarction, and retroplacental hemorrhage. If information is available, it is preferable to annotate using the HPO terms that corresponding to the specific abnormalities.
http://purl.obolibrary.org/obo/HP_0025720	Limited horizontal extraocular movement	http://purl.obolibrary.org/obo/HP_0007941	Limited extraocular movements		Limited mobility of the eye to move from side to side (horizontally) within its socket.
http://purl.obolibrary.org/obo/HP_0025721	Limited vertical extraocular movement	http://purl.obolibrary.org/obo/HP_0007941	Limited extraocular movements		Limited mobility of the eye to move up and down (vertically) within its socket.
http://purl.obolibrary.org/obo/HP_0025722	Cerebral infarct	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		A necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors.
http://purl.obolibrary.org/obo/HP_0025724	Caseous vernix-like desquamation	http://purl.obolibrary.org/obo/HP_0025723	Abnormal fetal skin morphology		Vernix caseosa is a physiological, viscous biofilm that is produced by desquamated fetal skin and sebaceous glands covering the fetus at the third trimester in-utero. The substance's gross morphology in post-partum is described by the etymology, as vernix means varnish, and caseosa means cheesy-like matter. This finding refers to an abnormally thick and greasy vernix caseosa-like scale present at birth.
http://purl.obolibrary.org/obo/HP_0025725	Type 1 congenital pulmonary airway malformation	http://purl.obolibrary.org/obo/HP_0010959	Congenital pulmonary airway malformation		A type of congenital pulmonary airway malformation that is characterized by multiple large cysts or a single dominant cyst.
http://purl.obolibrary.org/obo/HP_0025726	Type 2 congenital pulmonary airway malformation	http://purl.obolibrary.org/obo/HP_0010959	Congenital pulmonary airway malformation		A type of congenital pulmonary airway malformation that is characterized by multiple evenly spaced cysts (sponge-like appearance).
http://purl.obolibrary.org/obo/HP_0025727	Type 3 congenital pulmonary airway malformation	http://purl.obolibrary.org/obo/HP_0010959	Congenital pulmonary airway malformation		A type of congenital pulmonary airway malformation that is characterized by a bulky firm mass with an adenomatoid appearance.
http://purl.obolibrary.org/obo/HP_0025728	Periventricular pseudocyst	http://purl.obolibrary.org/obo/HP_0002518	Abnormal periventricular white matter morphology		Pseudocysts that lack an epithelial lining, PVPCs are frequently observed in the caudothalamic groove or in the infero-lateral aspect of the frontal horns of the lateral ventricles, but may also be located elsewhere along the periventricular germinal matrix, as in the temporal or occipital horns.
http://purl.obolibrary.org/obo/HP_0025729	Fetal vascular malperfusion	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		The term fetal vascular malperfusion (FVM) is used to describe placental pathology that is thought to result from an obstruction in fetal blood flow that could result from a number of conditions (eg, umbilical cord lesions, hypercoagulability, complications of fetal cardiac dysfunction, such as hypoxia, etc.).
http://purl.obolibrary.org/obo/HP_0025730	Foramen ovale aneurysm	http://purl.obolibrary.org/obo/HP_0010948	Abnormal fetal cardiovascular morphology		Foramen ovale aneurysm (FOA) or atrial septal aneurysm is abnormal redundancy of the atrial septum primum, with bulging of the septum by at least half the width of the atrial chamber, or by at least 10 mm beyond the level of the atrial septum. The abnormal protrusion of the interatrial septum results in decreased left atrial volume. On color Doppler there is reduced left ventricular inflow.
http://purl.obolibrary.org/obo/HP_0034043	Increased fecal bile acid	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		Elevated amount of bile acids in the feces.
http://purl.obolibrary.org/obo/HP_0034044	Trident pelvis	http://purl.obolibrary.org/obo/HP_0001384	Abnormal hip joint morphology		Spurs at the medial and lateral acetabular margin and in the center of the acetabulum gives rise to shape resembling a three-pronged spear known as trident.
http://purl.obolibrary.org/obo/HP_0034045	Angulated muscle fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Normal muscle fibers are polygonal-shaped in cross section, are multinucleated, and have minimal amounts of endomysial connective tissue. In contrast, angulated (also known as angular) muscle fibers have long and narrow vertices (corners) with sharp edges and a pointed tip.
http://purl.obolibrary.org/obo/HP_0034046	Mandibular osteolysis	http://purl.obolibrary.org/obo/HP_0002797	Osteolysis		Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to the mandible.
http://purl.obolibrary.org/obo/HP_0034047	Rib osteolysis	http://purl.obolibrary.org/obo/HP_0002797	Osteolysis		Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to a rib.
http://purl.obolibrary.org/obo/HP_0034048	Decreased circulating chenodeoxycholic acid concentration	http://purl.obolibrary.org/obo/HP_0030985	Decreased serum bile acid concentration		A reduced concentration of chenodeoxycholic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034049	Elevated urinary prostaglandin E2 level	http://purl.obolibrary.org/obo/HP_0003527	Hyperprostaglandinuria		An increased amount of prostaglandin E2 in the urine.
http://purl.obolibrary.org/obo/HP_0034050	Elevated urinary prostaglandin E2 metabolite level	http://purl.obolibrary.org/obo/HP_0003527	Hyperprostaglandinuria		An increased amount of prostaglandin E2 metabolite (PGE-M) in the urine.
http://purl.obolibrary.org/obo/HP_0034051	Hypoplastic anterior limbs of the internal capsule	http://purl.obolibrary.org/obo/HP_0012502	Abnormality of the internal capsule		Underdevelopment of the frontal part (anterior crus or anterior limb) of the internal capsule.
http://purl.obolibrary.org/obo/HP_0034052	Impaired toe-walking ability	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		Difficulty or reduced ability to walk on toes. Toe-walking can be tested as a part of the neurological examination. Foot plantar flexion weakness leads to difficulties in walking on toes.
http://purl.obolibrary.org/obo/HP_0034054	Probst bundles	http://purl.obolibrary.org/obo/HP_0001273	Abnormal corpus callosum morphology		Probst bundles (also known as longitudinal callosal fascicles) are neuroanatomical homologues to the corpus callosum and can occur in association with callosal agenesis. Probst bundles are white matter fibers that normally cross the corpus callosum but (because of the agenesis of the corpus callosum) fail to cross the midline, such that when they reach the corticoseptal boundary, they turn and run parallel to the interhemispheric fissure within the septal leaves, indenting the medial walls of the lateral ventricles.
http://purl.obolibrary.org/obo/HP_0034055	Anti-side-chain cleavage enzyme antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc), which is encoded by CYP11A1 cytochrome P450 family 11 subfamily A member 1 (Gene ID:1583).
http://purl.obolibrary.org/obo/HP_0034056	Increased fecal calprotectin level	http://purl.obolibrary.org/obo/HP_0031685	Abnormal stool composition		An increased amount of calprotectin in the feces.
http://purl.obolibrary.org/obo/HP_0034057	Fetal anomaly	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate.
http://purl.obolibrary.org/obo/HP_0034060	Triggered by fava bean ingestion	http://purl.obolibrary.org/obo/HP_0033793	Triggered by food ingestion		Applies to a sign or symptom that is provoked or brought about by eating fava beans.
http://purl.obolibrary.org/obo/HP_0034061	Anti-steroid 17alpha-hydroxylase antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against steroid 17alpha-hydroxylase.
http://purl.obolibrary.org/obo/HP_0034062	Anti-insulin antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against insulin.
http://purl.obolibrary.org/obo/HP_0034063	Anti-islet antigen-2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against tyrosine phosphatase IA-2.
http://purl.obolibrary.org/obo/HP_0034064	Anti-salivary protein antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against salivary protein.
http://purl.obolibrary.org/obo/HP_0034065	Anti-Zinc transporter 8 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against zinc transporter 8.
http://purl.obolibrary.org/obo/HP_0034066	Anti-carbonic anhydrase VI antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase VI.
http://purl.obolibrary.org/obo/HP_0034067	Tonofilament clumping	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Formation of lumps of tonofilaments, which are bundles of keratin filaments. In some but not all epithelia, keratin filaments are conspicuously bundled as tonofilaments. Inside the cell they braid the nucleus, span through the cytoplasm and are attached to the cytoplasmic plaques of the typical epithelial cell-cell junctions, the desmosomes.
http://purl.obolibrary.org/obo/HP_0034068	Anti-plasminogen binding peptide antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against plasminogen binding peptide.
http://purl.obolibrary.org/obo/HP_0034069	Anti-parotid secretory protein antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against parotid secretory protein.
http://purl.obolibrary.org/obo/HP_0034070	Anti-enterocyte antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against enterocytes.
http://purl.obolibrary.org/obo/HP_0034071	Anti-21-hydroxylase antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against 21-hydroxylase.
http://purl.obolibrary.org/obo/HP_0034072	Abnormal fetal long-bone echogenicity	http://purl.obolibrary.org/obo/HP_0025662	Abnormal fetal skeletal morphology		Any deviation from the normal appearing echogenicity of the fetal bone. Echogenicity refers to the ability of tissue to reflect ultrasound waves back toward the transducer and produce an echo. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. The higher the echogenicity of tissues, the brighter they appear on ultrasound imaging.
http://purl.obolibrary.org/obo/HP_0034073	Reduced fetal long bone echogenicity	http://purl.obolibrary.org/obo/HP_0034072	Abnormal fetal long-bone echogenicity		An abnormally decreased echogenicity of fetal long bones in a prenatal sonographic investigation. This finding is due to hypomineralization and can be seen in some disorders such as hypophosphatasia, osteogenesis imperfecta, and achondrogenesis.
http://purl.obolibrary.org/obo/HP_0034074	Increased fetal long bone echogenicity	http://purl.obolibrary.org/obo/HP_0034072	Abnormal fetal long-bone echogenicity		An abnormally elevated echogenicity of fetal long bones in a prenatal sonographic investigation. This finding is due to hypermineralization.
http://purl.obolibrary.org/obo/HP_0034075	Decreased circulating apolipoprotein B concentration	http://purl.obolibrary.org/obo/HP_0033459	Decreased circulating apolipoprotein concentration		The concentration of apolipoprotein B in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034076	Anti-ribosome Po antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ribosome Po.
http://purl.obolibrary.org/obo/HP_0034077	Anti-complement component C1q antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against C1q.
http://purl.obolibrary.org/obo/HP_0034078	Anti-centromere protein A antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-A.
http://purl.obolibrary.org/obo/HP_0034079	Anti-centromere protein B antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-B.
http://purl.obolibrary.org/obo/HP_0034080	Anti-U3 RNP antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U3 RNP.
http://purl.obolibrary.org/obo/HP_0034081	Anti-Th/To antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Th/To.
http://purl.obolibrary.org/obo/HP_0034082	Anti-bicaudal D2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against bicaudal D2.
http://purl.obolibrary.org/obo/HP_0034083	Anti-nucleolus-organizing region antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Nor90.
http://purl.obolibrary.org/obo/HP_0034084	Anti-phosphatidyl ethanolamine antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl ethanolamine.
http://purl.obolibrary.org/obo/HP_0034085	Anti-PM-Scl100 antibody positivity	http://purl.obolibrary.org/obo/HP_0033560	Anti-PM-Scl antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl100.
http://purl.obolibrary.org/obo/HP_0034086	Anti-PM-Scl75 antibody positivity	http://purl.obolibrary.org/obo/HP_0033560	Anti-PM-Scl antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl75.
http://purl.obolibrary.org/obo/HP_0034087	Anti-U11/U12 RNP antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U11/U12 RNP.
http://purl.obolibrary.org/obo/HP_0034088	Anti-Ku antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ku.
http://purl.obolibrary.org/obo/HP_0034089	Anti-B23 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against B23.
http://purl.obolibrary.org/obo/HP_0034090	Anti-RuvBL1/2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against RuvBL1/2.
http://purl.obolibrary.org/obo/HP_0034091	Anti-platelet derived growth factor receptor	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against platelet derived growth factor receptor.
http://purl.obolibrary.org/obo/HP_0034092	Anti-cyclic citrullinated peptide antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cyclic citrullinated peptide.
http://purl.obolibrary.org/obo/HP_0034093	Anti-Ro52/TRIM21 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro52/TRIM21.
http://purl.obolibrary.org/obo/HP_0034094	Anti-angiotensin receptor type-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin receptor type-1.
http://purl.obolibrary.org/obo/HP_0034095	Anti-endothelin-1 type A receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endothelin-1 type A receptor.
http://purl.obolibrary.org/obo/HP_0034096	Anti-phosphatidic acid antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidic acid.
http://purl.obolibrary.org/obo/HP_0034097	Anti-phosphatidyl choline antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl choline.
http://purl.obolibrary.org/obo/HP_0034098	Anti-phosphatidyl glycerol antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl glycerol.
http://purl.obolibrary.org/obo/HP_0034099	Anti-phosphatidyl inositol antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl inositol.
http://purl.obolibrary.org/obo/HP_0034100	Anti-phosphatidyl serine antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl serine.
http://purl.obolibrary.org/obo/HP_0034101	Anti-annexin-V antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against annexin-V.
http://purl.obolibrary.org/obo/HP_0034102	Anti-sphingolipid antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against sphingolipids.
http://purl.obolibrary.org/obo/HP_0034103	Anti-GM1 antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		Ganglioside-monosialic acid (GM1) is a type of glycosphingolipid with one sialic acid. GM1 is located on the outer layer of the plasma membrane, and plays a vital role in neurogenesis, nerve development, differentiation and repair after injury
http://purl.obolibrary.org/obo/HP_0034104	Anti-neutrophil elastase antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neutrophil elastase.
http://purl.obolibrary.org/obo/HP_0034105	Anti-transcription intermediary factor-1gamma antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against transcription intermediary factor-1gamma.
http://purl.obolibrary.org/obo/HP_0034106	Anti-Su antigen/argonaute 2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Su antigen/argonaute 2.
http://purl.obolibrary.org/obo/HP_0034107	Anti-p53 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against p53.
http://purl.obolibrary.org/obo/HP_0034108	Anti-Y-box protein-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Y-box protein-1.
http://purl.obolibrary.org/obo/HP_0034109	Anti-GW182 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GW182.
http://purl.obolibrary.org/obo/HP_0034110	Anti-Gerbich phenotype 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ge-1.
http://purl.obolibrary.org/obo/HP_0034111	Anti-MIT3 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against MIT3.
http://purl.obolibrary.org/obo/HP_0034112	Anti-GM1 IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0034103	Anti-GM1 antibody positivity		The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GM1.
http://purl.obolibrary.org/obo/HP_0034114	Anti-hexokinase-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against hexokinase-1.
http://purl.obolibrary.org/obo/HP_0034115	Anti-Kelch like protein 12 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Kelch like protein 12.
http://purl.obolibrary.org/obo/HP_0034117	Anti-angiotensin-converting enzyme 2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin-converting enzyme 2.
http://purl.obolibrary.org/obo/HP_0034118	Anti-GM1 IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0034103	Anti-GM1 antibody positivity		The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GM1.
http://purl.obolibrary.org/obo/HP_0034119	Anti-GD1a IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0034121	Anti-GD1a antibody positivity		The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a.
http://purl.obolibrary.org/obo/HP_0034120	Anti-GD1a IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0034121	Anti-GD1a antibody positivity		The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a.
http://purl.obolibrary.org/obo/HP_0034121	Anti-GD1a antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a.
http://purl.obolibrary.org/obo/HP_0034122	Anti-GQ1b antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b.
http://purl.obolibrary.org/obo/HP_0034123	Anti-GQ1b IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0034122	Anti-GQ1b antibody positivity		The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b.
http://purl.obolibrary.org/obo/HP_0034124	Anti-GD1b antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside.
http://purl.obolibrary.org/obo/HP_0034125	Anti-GD1b IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0034124	Anti-GD1b antibody positivity		The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside.
http://purl.obolibrary.org/obo/HP_0034126	Anti-GD1b IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0034124	Anti-GD1b antibody positivity		The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside.
http://purl.obolibrary.org/obo/HP_0034127	Anti-GQ1b IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0034122	Anti-GQ1b antibody positivity		The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b.
http://purl.obolibrary.org/obo/HP_0034128	Anti-GT1a antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside.
http://purl.obolibrary.org/obo/HP_0034129	Anti-GT1a IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0034128	Anti-GT1a antibody positivity		The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside.
http://purl.obolibrary.org/obo/HP_0034130	Anti-GT1a IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0034128	Anti-GT1a antibody positivity		The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside.
http://purl.obolibrary.org/obo/HP_0034131	Anti-GT1b antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against T1b ganglioside.
http://purl.obolibrary.org/obo/HP_0034132	Anti-GM2 antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM2.
http://purl.obolibrary.org/obo/HP_0034133	Anti-GM3 antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM3.
http://purl.obolibrary.org/obo/HP_0034134	Anti-GM4 antibody positivity	http://purl.obolibrary.org/obo/HP_0031810	Anti-ganglioside antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM4.
http://purl.obolibrary.org/obo/HP_0034135	Anti-neurofascin-155 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF155.
http://purl.obolibrary.org/obo/HP_0034136	Anti-neurofascin 186 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF186.
http://purl.obolibrary.org/obo/HP_0034137	Anti-contactin-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CNTN1.
http://purl.obolibrary.org/obo/HP_0034138	Anti-contactin-associated protein 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034137	Anti-contactin-1 antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-contactin-associated protein 1.
http://purl.obolibrary.org/obo/HP_0034139	Anti-SUMO-activating enzyme antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE.
http://purl.obolibrary.org/obo/HP_0034140	Anti-SUMO-activating enzyme subunit 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034139	Anti-SUMO-activating enzyme antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 1.
http://purl.obolibrary.org/obo/HP_0034141	Anti-SUMO-activating enzyme subunit 2 antibody positivity	http://purl.obolibrary.org/obo/HP_0034139	Anti-SUMO-activating enzyme antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 2.
http://purl.obolibrary.org/obo/HP_0034142	Anti-nuclear matrix protein-2 antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NXP-2.
http://purl.obolibrary.org/obo/HP_0034143	Anti-threonyl-tRNA synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against threonyl-tRNA synthetase.
http://purl.obolibrary.org/obo/HP_0034144	Anti-hY-RNA complex antibody positivity	http://purl.obolibrary.org/obo/HP_0033476	Extractable nuclear antigen positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro60.
http://purl.obolibrary.org/obo/HP_0034145	Anti-alanyl-tRNA synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against alanyl-tRNA synthetase.
http://purl.obolibrary.org/obo/HP_0034146	Anti-glycyl tRNA-synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glycyl tRNA-synthetase.
http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a tRNA synthetase enzyme.
http://purl.obolibrary.org/obo/HP_0034148	Anti-isoleucyl tRNA-synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against isoleucyl tRNA-synthetase.
http://purl.obolibrary.org/obo/HP_0034149	Anti-phenylalanyl tRNA synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phenylalanyl tRNA synthetase.
http://purl.obolibrary.org/obo/HP_0034150	Anti-tyrosyl-tRNA synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against tyrosyl-tRNA synthetase.
http://purl.obolibrary.org/obo/HP_0034151	Anti-asparaginyl-tRNA synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against asparaginyl-tRNA synthetase.
http://purl.obolibrary.org/obo/HP_0034152	Anti-histidyl tRNA synthetase antibody positivity	http://purl.obolibrary.org/obo/HP_0034147	Anti-aminoacyl-tRNA synthetase antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against histidyl tRNA synthetase.
http://purl.obolibrary.org/obo/HP_0034153	Anti-cytosolic-5-nucleotidase-1A antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cytosolic-5-nucleotidase-1A (cN1A).
http://purl.obolibrary.org/obo/HP_0034154	Anti-Ki antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ki.
http://purl.obolibrary.org/obo/HP_0034155	Anti-sp100 antibody positivity	http://purl.obolibrary.org/obo/HP_0025353	Anti-multiple nuclear dots antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against sp100. Autoantibodies causing the MND pattern are directed against sp100, sp140, promyelocytic leukemia nuclear body proteins (PML) or ubiquitin-like modifier (SUMO) proteins, while in the punctate nuclear envelope pattern, the target antigens are gp210, nucleoporin-62 or laminin B receptor proteins.
http://purl.obolibrary.org/obo/HP_0034156	Anti-beta-2-Glycoprotein I IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0032376	Anti-beta 2 glycoprotein I antibody positivity		Presence of IgG antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome.
http://purl.obolibrary.org/obo/HP_0034157	Anti-beta-2-Glycoprotein I IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0032376	Anti-beta 2 glycoprotein I antibody positivity		Presence of IgM antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome.
http://purl.obolibrary.org/obo/HP_0034158	Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity	http://purl.obolibrary.org/obo/HP_0034063	Anti-islet antigen-2 antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against the tyrosine phossphatase region of islet antigen 2A (this region is a specific part of IA-2). Usually IA-2A are measured using the intracellular portion of IA-2 (IA-2ic) made up of the protein tyrosine phosphatase (PTP) and juxtamembrane (JM) regions.
http://purl.obolibrary.org/obo/HP_4000066	Abnormal iliac artery morphology	http://purl.obolibrary.org/obo/HP_0020317	Abnormal abdominal aorta branch artery morphology		Any structural anomaly of the iliac artery.
http://purl.obolibrary.org/obo/CHEBI_194548	4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol	http://purl.obolibrary.org/obo/CHEBI_33567	catecholamine		A catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen.
http://purl.obolibrary.org/obo/CL_4033044	deuterosomal cell	http://purl.obolibrary.org/obo/CL_0002368	respiratory tract epithelial cell		An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis.
http://purl.obolibrary.org/obo/CL_4030058	TCR-positive macrophage	http://purl.obolibrary.org/obo/CL_0000235	macrophage		A macrophage that expresses the T cell receptor complex at the cell surface.
http://purl.obolibrary.org/obo/CL_4030066	ureteric bud cell	http://purl.obolibrary.org/obo/CL_0002518	kidney epithelial cell		An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion.
http://purl.obolibrary.org/obo/CL_4033057	luminal adaptive secretory precursor cell of mammary gland	http://purl.obolibrary.org/obo/CL_0011026	progenitor cell		A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8.
http://purl.obolibrary.org/obo/UBERON_8600024	pulmonary venule	http://purl.obolibrary.org/obo/UBERON_0003512	lung blood vessel		A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa.
http://purl.obolibrary.org/obo/HP_0430106	Abnormal brain-evoked potentials	http://purl.obolibrary.org/obo/HP_0030178	Abnormality of central nervous system electrophysiology		Any anomaly of brain-evoked potentials, defined as potentials generated by exteroceptive stimuli reflect synchronized activity by neuronal and axonal groups in the central nervous system (CNS) resulting from the arrival of nerve impulses after stimulation of a peripheral nerve or its receptors. Depending on the type of stimulus, evoked potentials are categorized as visual (VEP), auditory (AEP), or somatosensory (SSEP). Motor evoked potentials (MEP) occur when the brain's motor area is stimulated. They result from the activation of a sufficient number of motor units.
http://purl.obolibrary.org/obo/HP_0430135	Abnormal circulating hepatic transaminase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Any deviation from the normal concentration in the blood circulation of alanine aminotransferase or aspartate aminotransferase.
http://purl.obolibrary.org/obo/HP_0025756	Abnormal nail attachment	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		An anomaly of the connection of the nail to the nailbed.
http://purl.obolibrary.org/obo/HP_0025757	Abnormal nail surface	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		An anomaly of the surface of the nail.
http://purl.obolibrary.org/obo/HP_0025779	Disorder of thought content	http://purl.obolibrary.org/obo/HP_0025792	Abnormal cognitive process		Thought content disorders are characterized by abnormal beliefs and convictions (that are to be assessed given the culture and personal background of the affected individual).
http://purl.obolibrary.org/obo/HP_0025780	Abnormal volitional state	http://purl.obolibrary.org/obo/HP_0025766	Abnormal affect		An abnormality of internal states of motivation or drive that compromise, or interfere with, the ability of the person to attend to basic personal, social, or vocational activities.
http://purl.obolibrary.org/obo/HP_0025783	Diagnostic behavioral phenotype	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		The Human Phenotype Ontology provides terms to describe specific phenotypic abnormalities rather than disease diagnoses. Nevertheless, it is common for descriptions such as 'Autism' to be used to describe individuals affected with Mendelian forms of neurodevelopmental disease and many other conditions. If possible, we recommend annotation using specific terms in other branchs of the Atypical behavior subontology, but if this is not possible, then terms from this branch may be used.
http://purl.obolibrary.org/obo/HP_6000918	Transverse terminal upper limb defect	http://purl.obolibrary.org/obo/HP_6000818	Transverse terminal limb defect		A congenital anomaly that appears as an amputation at different levels of the arm, e.g. humerus, proximal forearm, wrist or finger. The limb is missing the terminal (distal) segment(s), with preservation of all the segment(s) proximal to the missing segment.
http://purl.obolibrary.org/obo/HP_6000899	Positive skin scabies test	http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test		Identification of scabies by means of an examination of the skin such as microscopic identification of scabies mites, eggs, or feces from obtained scales by skin scraping.
http://purl.obolibrary.org/obo/HP_6000900	Positive mumps virus PCR test in the blood circulation	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of the mumps virus in the blood circulation by a method such as polymerase chain reaction (PCR) or reverse transcriptase (RT)-PCR.
http://purl.obolibrary.org/obo/HP_6000901	Positive bloodstream tuberculosis-induced T-cell-based interferon-gamma release assay	http://purl.obolibrary.org/obo/HP_0430150	Positive blood infectious agent test		Detection of Mycobacterium tuberculosis in the bloodstream by means of detection of interferon-gamma secreted by T cells in response to specific antigens from Mycobacterium tuberculosis, commonly 6kD early secretory antigenic target-6 and 10kD culture filtrate protein-10.
http://purl.obolibrary.org/obo/HP_6000902	Positive blood Neisseria gonorrhoeae culture	http://purl.obolibrary.org/obo/HP_0031864	Bacteremia		Growth of Neisseria gonorrhoeae in a culture derived from circulating blood.
http://purl.obolibrary.org/obo/HP_6000903	Anti-mumps antibody positivity	http://purl.obolibrary.org/obo/HP_0430059	Bloodstream virus-specific antibody positivity		The presence of antibodies in the blood circulation that react against a component of Mumps virus.
http://purl.obolibrary.org/obo/HP_6000904	Positive Vibrio cholerae stool culture	http://purl.obolibrary.org/obo/HP_0034866	Positive stool infectious agent test		Growth of Vibrio cholerae in a culture derived from a feces sample.
http://purl.obolibrary.org/obo/HP_6000905	Positive cutaneous varicella zoster virus nucleic acid test	http://purl.obolibrary.org/obo/HP_0430117	Positive skin infectious agent test		Detection of mucocutaneous varicella zoster virus nucleic acid in the skin by a method such as polymerase chain reaction. The sample is usually obtained by swab from skin or mucous membranes.
http://purl.obolibrary.org/obo/HP_6000906	Positive bloodstream cryptococcus culture	http://purl.obolibrary.org/obo/HP_5210107	Disseminated Cryptococcus infection		Growth of Cryptococcus in a culture derived from a blood sample.
http://purl.obolibrary.org/obo/HP_6000907	Positive bloodstream Borrelia miyamotoi nucleic acid test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of Borrelia miyamotoi in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000908	Positive bloodstream Coxsackievirus nucleic acid pathogen test	http://purl.obolibrary.org/obo/HP_0430067	Positive bloodstream nucleic acid pathogen test		Detection of nucleic acid of Coxsackievirus in the blood circulation by a method such as polymerase chain reaction (PCR).
http://purl.obolibrary.org/obo/HP_6000910	Diminished tissue alpha-L-iduronidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of alpha-L-iduronidase (IDUA; EC 3.2.1.76) below the lower limit of normal. FECH enzyme can be measured in multiple tissues including cultured fibroblasts and leukocytes.
http://purl.obolibrary.org/obo/HP_6000911	Reduced tissue neuraminidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of neuraminidase (EC 3.2.1.18)in tissues below the lower limit of normal. The activity can be measured in multiple tissues including culutured fibroblasts. Neuraminidase is also known as lysosomal sialidase.
http://purl.obolibrary.org/obo/HP_6000912	Nummular keratitis	http://purl.obolibrary.org/obo/HP_0000491	Keratitis		Nummular keratitis consists of multiple scattered small round anterior corneal superficial stromal infiltrates.
http://purl.obolibrary.org/obo/HP_6000913	Swelling of inguinal region	http://purl.obolibrary.org/obo/HP_0004298	Abnormal abdominal wall morphology		Bulging in the area of the lower abdomen, just above the thigh and near the groin.
http://purl.obolibrary.org/obo/HP_6000914	Single lesion	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance are solitary and localized to a part of the skin, a tissue or an organ that differs from the surrounding healthy tissue.
http://purl.obolibrary.org/obo/HP_6000915	Dysorthography	http://purl.obolibrary.org/obo/HP_0001328	Specific learning disability		A specific disorder of spelling. A score on a standardized spelling test is at least two standard errors of prediction below the level expected on the basis of the child's chronological age and general intelligence in the context of scores on reading accuracy and comprehension and on arithmetic that are within the normal range (within two standard deviations from the mean).
http://purl.obolibrary.org/obo/HP_6000916	Echogenic fetal colon	http://purl.obolibrary.org/obo/HP_0010943	Echogenic fetal bowel		A type of echogenic fetal bowel in which the hyperechogenicity is strictly limited to the colon.
http://purl.obolibrary.org/obo/HP_6000917	Bone marrow edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Accumulation of excess fluid in the bone marrow.
http://purl.obolibrary.org/obo/HP_6000919	Trousseau sign	http://purl.obolibrary.org/obo/HP_0003394	Muscle spasm		After inflating a blood pressure cuff from 10 mm Hg to 20 mm Hg over the patient's systolic blood pressure, the Trousseau sign is considered positive if carpal spasm develops, with flexion of the thumb and adduction of the finger within 3 minutes. However, this can be painful, so the time should be noted, and the cuff should be deflated once the test is positive.
http://purl.obolibrary.org/obo/HP_6000920	Craniocervical junction constriction	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		Congenital or acquired abnormalities of the occipital bone, foramen magnum, or first two cervical vertebrae that decrease the space for the lower brain stem and cervical cord. These malformations can lead to cranial nerve compression, vertebral artery compression, and obstructive hydrocephalus.
http://purl.obolibrary.org/obo/HP_6000921	Fibular torsion	http://purl.obolibrary.org/obo/HP_0002991	Abnormal fibula morphology		Excessively rotated (also called torsion) position of the fibula (calf bone). An increased external rotation of the fibula in the incisura tibiofibularis of more than 5 degrees may lead to an increased pressure and will negatively affect the cartilage.
http://purl.obolibrary.org/obo/HP_6000922	Abnormal finger phalanx ossification	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		Any abnormal process of ossification of the phalangeal bones, which normally are ossified from the body and proximal extremity. Ossification of the body commences during the eighth week of fetal development. Ossification of the proximal extremity commences in the bones between the third and fourth years.
http://purl.obolibrary.org/obo/HP_6000923	Positive bloodstream EBV monospot test	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		The monospot test is a latex agglutination test which utilizes equine erythrocytes as the primary substrate and tests for specific heterophile antibodies produced by the human immune system in response to EBV infection. When these specific antibodies are present in the patient's blood specimen, exposure to equine erythrocytes will lead to clumping of the sample, thus signaling a positive agglutination reaction.
http://purl.obolibrary.org/obo/HP_6000924	Positive CSF Toxoplasma gondii antibody positivity	http://purl.obolibrary.org/obo/HP_0430139	CSF pathogen-specific antibody positivity		The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of Toxoplasma gondii.
http://purl.obolibrary.org/obo/HP_6000925	Positive tuberculin skin test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		A positive result of the tuberculin skin test suggesting previous expouse or infection with mycobacterium teberculosis. A standard dose of five tuberculin units (TU) (0.1ml) is injected intradermally (into the skin) and read 48 to 72 h later. A person who has been exposed to the bacteria is expected to mount an immune response in the skin containing the bacterial proteins. The volar aspect of the forearm is the preferred site of test. The basis of reading is the presence or absence of induration, which may be determined by inspection (from a side view against the light as well as by direct light) and by palpation. For standardization, the diameter of induration should be measured transversely to the long axis of the forearm and recorded in millimeters.
http://purl.obolibrary.org/obo/HP_6000926	Anti-Treponema pallidum antibody positivity	http://purl.obolibrary.org/obo/HP_0430061	Bloodstream antibacterial antibody positivity		The presence of antibodies in the blood circulation that react against a component of Treponema pallidum.
http://purl.obolibrary.org/obo/HP_6000927	Positive CSF Borrelia burgdorferi antibody positivity	http://purl.obolibrary.org/obo/HP_0430139	CSF pathogen-specific antibody positivity		The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of Borrelia burgdorferi.
http://purl.obolibrary.org/obo/HP_6000928	Positive CSF JC-virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430139	CSF pathogen-specific antibody positivity		The presence of antibodies in the cerebrospinal fluid (CSF) that react against a component of JC-virus (also known as JC-polyomavirus and John Cunningham virus).
http://purl.obolibrary.org/obo/HP_6000929	Neutralizing anti-rabies virus antibody positivity	http://purl.obolibrary.org/obo/HP_0430051	Bloodstream pathogen-specific antibody positivity		The presence of antibodies in the blood circulation that act against the rabies virus function by blocking the binding of the glycoprotein to a receptor or preventing the membrane fusion process.
http://purl.obolibrary.org/obo/HP_6000930	Impaired hepatobiliary scintigraphy tracer uptake	http://purl.obolibrary.org/obo/HP_0025155	Abnormal hepatobiliary system physiology		An abnormal reduction in the amount of radioactive tracer uptake upon hepatobiliary scintigraphy.
http://purl.obolibrary.org/obo/HP_6000931	Calcified pulmonary nodule	http://purl.obolibrary.org/obo/HP_0033608	Pulmonary nodule		A pulmonary nodule with calcium deposits. On radiography, these nodules appear dense.
http://purl.obolibrary.org/obo/HP_6000932	Postprandial exacerbation	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is more severe following a meal.
http://purl.obolibrary.org/obo/HP_6000933	Koebner Phenomenon	http://purl.obolibrary.org/obo/HP_0011122	Abnormal skin physiology		The appearance of new skin lesions on previously unaffected skin secondary to trauma. This phenomenon is also termed the isomorphic (from Greek, equal shape) response, given the fact that the new lesions that appear are clinically and histologically identical to the patient's underlying cutaneous disease.
http://purl.obolibrary.org/obo/HP_6000934	Glenoid dysplasia	http://purl.obolibrary.org/obo/HP_0011912	Abnormality of the glenoid fossa		Glenoid dysplasia is a developmental anomaly of the scapula that is characterized by a bony deficiency of the posteroinferior glenoid and the adjacent scapular neck.
http://purl.obolibrary.org/obo/HP_6000935	Prolonged retraction of penile foreskin	http://purl.obolibrary.org/obo/HP_4000144	Recent past medical history		A past medical history of recently having retracted the penile foreskin for a prolonged period of time. Paraphimosis commonly occurs iatrogenically, when the foreskin is retracted for cleaning, placement of a urinary catheter, a procedure such as a cystoscopy, or for penile examination. Failure to return the retracted foreskin over the glans promptly after the initial retraction can lead to paraphimosis.
http://purl.obolibrary.org/obo/HP_6000936	Thickened cortex of the clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		Abnormal thickening of the cortex of the clavicle.
http://purl.obolibrary.org/obo/HP_6000937	Thickened cortex of the mandible	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		Abnormal thickening of the cortex of the mandible.
http://purl.obolibrary.org/obo/HP_6000938	Thumb hypoplasia grade 1	http://purl.obolibrary.org/obo/HP_0009778	Short thumb		Minor hypoplasia (developmental undergrowth) of the thumb, whereby all musculoskeletal and neurovascular components of the digit are present, just small in size (Blauth classification).
http://purl.obolibrary.org/obo/HP_6000939	Thumb hypoplasia grade 2	http://purl.obolibrary.org/obo/HP_0009778	Short thumb		A type of developmental undergrowth of the thumb, whereby all of the osseous structures are present (may be small), and there is metacarpophalangeal joint ulnar collateral ligament instability and thenar hypoplasia.
http://purl.obolibrary.org/obo/HP_6000940	Thumb hypoplasia grade 3A	http://purl.obolibrary.org/obo/HP_0009778	Short thumb		A type of developmental undergrowth of the thumb, whereby there are musculotendinous and osseous deficiencies with the carpometacarpal (CMC) joint intact. Absence of active motion at the metacarpophalangeal (MCP) or interphalangeal (IP) joint.
http://purl.obolibrary.org/obo/HP_6000941	Thumb hypoplasia grade 3B	http://purl.obolibrary.org/obo/HP_0009778	Short thumb		A type of developmental undergrowth of the thumb, whereby there are musculotendinous and osseous deficiencies characterized by basal metacarpal aplasia with deficient carpometacarpal (CMC) joint, and absence of metacarpophalangeal (MCP) or interphalangeal (IP) joint.
http://purl.obolibrary.org/obo/HP_6000942	Thumb hypoplasia grade 4	http://purl.obolibrary.org/obo/HP_0009778	Short thumb		A type of developmental undergrowth of the thumb characterized by attachment to the hand only by the skin and digital neurovascular structures.
http://purl.obolibrary.org/obo/HP_6000943	Femoral osteopoikilosis	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		Multiple multiple, small, well-defined radiodense foci of cortical-like bone in the medullary space parallel to the trabeculae located in the femur. The loci correspond to condensations of the lamellar trabeculae on histology.
http://purl.obolibrary.org/obo/HP_6000944	Carotidynia	http://purl.obolibrary.org/obo/HP_0046506	Pain in head and neck region		Pain or tenderness in the region of the carotid artery.
http://purl.obolibrary.org/obo/HP_6000945	Asymmetric blood pressure between arms	http://purl.obolibrary.org/obo/HP_0025749	Asymmetric blood pressure between limbs		A substantial difference in blood pressure (e.g., 20 mmHg) between the right and left arms.
http://purl.obolibrary.org/obo/HP_6000947	Hemimelia of lower leg	http://purl.obolibrary.org/obo/HP_6000946	Transverse terminal lower limb defect		A developmental defect leading to a transverse deficiency with absence of the lower leg (eg tibia and fibula), ankle and foot.
http://purl.obolibrary.org/obo/HP_6000948	Hemimelia of forearm	http://purl.obolibrary.org/obo/HP_6000918	Transverse terminal upper limb defect		A developmental defect leading to a transverse deficiency with absence of the forearm (eg ulna and radius), wrist and hand.
http://purl.obolibrary.org/obo/HP_6000949	Sodium glucose transport inhibitor exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treateed with a sodium glucose transport inhibitors such as dapagliflozin, empagliflozin, canagliflozin, sglt-i, SGLT2, bexagliflozin, ertugliflozin, sotagliflozin, jardiance, invokana, forxiga, brenzavvy, steglatro, inpefa.
http://purl.obolibrary.org/obo/HP_6000950	Breath-holding spell	http://purl.obolibrary.org/obo/HP_0002793	Abnormal pattern of respiration		A benign paroxysmal nonepileptic disorder occurring in healthy children 6 to 48 months of age. The episodes start with a provocation such as emotional upset or minor injury, and might progress to breath holding, cyanosis, and syncope.
http://purl.obolibrary.org/obo/HP_6000951	Flared proximal tibial metaphysis	http://purl.obolibrary.org/obo/HP_0030307	Flared lower limb metaphysis		The presence of a splayed (i.e.,flared) metaphyseal segment of the proximal tibia.
http://purl.obolibrary.org/obo/HP_6000952	Delayed toe phalanx ossification	http://purl.obolibrary.org/obo/HP_0010675	Abnormal foot bone ossification		Delayed maturation and calcification of any of the toe phalanges.
http://purl.obolibrary.org/obo/HP_6000953	Sorbitol ingestion	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A history of ingestion of a relatively high amount of foods containing sorbitol.
http://purl.obolibrary.org/obo/HP_6000954	Positive peritoneal fluid bacterial culture	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Growth of bacteria in a culture dervied from ascites fluid.
http://purl.obolibrary.org/obo/HP_6000955	Ocular cystine crystal deposition	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		Accumulation of cystine crsytals in the eye. Patients present with crystal accumulation affecting the cornea and conjunctiva, but crystals can also be deposited in the iris, ciliary body, choroid and retinal pigment epithelium (RPE), and lens capsule. Corneal crystal deposition starts in infancy in the anterior periphery of the cornea, and progresses centrally and posteriorly. The crystals, which have a fine, uniform needle-shaped structure, are diffusely distributed within the corneal tissues.
http://purl.obolibrary.org/obo/HP_6000956	Exuberant granulation tissue	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A manifestation of abnormal wound healing in which there is formation of excessive granulation tissue, with the granulation tissue rising above the level of surrounding skin and creating a raised, reddish, moist, and bumpy surface.
http://purl.obolibrary.org/obo/HP_6000957	Oral mucosal papule	http://purl.obolibrary.org/obo/HP_3000019	Abnormal buccal mucosa morphology		A small (less than 5 mm in diameter), elevated, circumscribed, solid, palpable mass located in thte mucosa of the oral cavity.
http://purl.obolibrary.org/obo/HP_6000958	Excessive piloerection	http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology		Abnormally increased degree of goose bump formation, that is, of involuntary formation of bumps on a person's skin at the base of body hairs.
http://purl.obolibrary.org/obo/HP_6000959	Scalp edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		A palpable swelling in the scalp caused by an increase in interstitial fluid volume (excess fluid).
http://purl.obolibrary.org/obo/HP_6000960	Serpiginous burrow	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		A slightly raised and often reddish serpentine or curvilinear path in the skin.
http://purl.obolibrary.org/obo/HP_6000961	Positive brain-tissue rabies nucleic acid test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Detection of rabies nucleic acid in brain tissue by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000962	Positive respiratory tract Bordetella pertussis nucleic acid test	http://purl.obolibrary.org/obo/HP_6000836	Positive respiratory tract nucleic acid pathogen test		Detection of Bordetella pertussis PCR nucleic acid in in nasopharyngeal secretions by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6000963	Demonstration of acid-fast bacilli in wound tissue	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Demonstration of acid-fast bacilli by microscopic examination of wound tissue. Acid fastness is a physical property that gives a bacterium the ability to resist decolorization by acids during staining procedures.
http://purl.obolibrary.org/obo/HP_6000964	Positive tissue encapsulated budding yeast test	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Identification of encapsulated budding yeasts in smears of body fluids, secretions, exudates, or other specimens.
http://purl.obolibrary.org/obo/HP_6000965	Positive tissue coccidioidomycosis culture	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Growth of coccidioidomycosis in a culture derived from skin or an organ.
http://purl.obolibrary.org/obo/HP_6000966	Diminished tissue dihydropteridine reductase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of dihydropteridine reductase (EC 1.6.99.7) below the lower limit of normal. This enzyme can be measured in multiple tissues including leukocytes and erythrocytes.
http://purl.obolibrary.org/obo/HP_6000967	Decreased circulating transcobalamin-1 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of transcobalamin-1 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000968	Decreased circulating cationic trypsinogen concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of cationic trypsinogen in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000969	Diminished circulating hyaluronidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		The activity or concentration of hyaluronidase in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000970	Diminished sulfotransferase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Rate of proteoglycan sulfation (sulfotransferase activity) is below the lower limit of normal in cultured fibroblasts.
http://purl.obolibrary.org/obo/HP_6000971	Elevated tissue alpha-N-acetylglucosaminidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of alpha-N-acetylglucosaminidase (EC 3.2.1.50) above the upper limit of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts. It is also known as alpha-acetylglucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, and alpha-D-2-acetamido-2-deoxyglucosidase.
http://purl.obolibrary.org/obo/HP_6000972	Abnormal tissue alpha-N-acetylglucosaminidase activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of alpha-N-acetylglucosaminidase (EC 3.2.1.50) outside of the limits of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts. It is also known as alpha-acetylglucosaminidase, N-acetyl-alpha-D-glucosaminidase, N-acetyl-alpha-glucosaminidase, and alpha-D-2-acetamido-2-deoxyglucosidase.
http://purl.obolibrary.org/obo/HP_6000973	Elevated circulating trihydroxycholestanoic acid concentration	http://purl.obolibrary.org/obo/HP_0011013	Abnormal circulating carbohydrate concentration		The concentration of trihydroxycholestanoic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000974	Elevated circulating glyoxylic acid concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of glyoxylic acid in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000975	Elevated CSF sepiapterin concentration	http://purl.obolibrary.org/obo/HP_0040207	Abnormal CSF pterin concentration		Concentration of sepiapterin in the cerebrospinal fluid (CSF) above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000976	Intrahepatic inclusion bodies	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Nuclear or cytoplasmic aggregates of stainable substances within hepatocytes.
http://purl.obolibrary.org/obo/HP_6000977	Muscle vacuoles	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions.
http://purl.obolibrary.org/obo/HP_6000978	Nonrimmed muscle vacuoles	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, non-rimmed vacuoles lack the prominent dark border (rim) seen in rimmed vacuoles.
http://purl.obolibrary.org/obo/HP_6000979	Reduced hepatic glycogen phosphorylase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity or concentration of glycogen phosphorylase L in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_6000980	Bone marrow hemophagocytosis	http://purl.obolibrary.org/obo/HP_0012156	Hemophagocytosis		Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages observed in the bone marrow.
http://purl.obolibrary.org/obo/HP_6000981	Splenic granulomatosis	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Splenic inflammation involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells.
http://purl.obolibrary.org/obo/HP_6000982	Immediate detumescence of penis at time of symptom onset	http://purl.obolibrary.org/obo/HP_0010461	Abnormality of the male genitalia		Loss of erection at the time point of pain or other symptom onset.
http://purl.obolibrary.org/obo/HP_6000983	History of aortic valve replacement	http://purl.obolibrary.org/obo/HP_0034420	History of cardiovascular procedure		History of having received a surgical replacement of the aortic valve.
http://purl.obolibrary.org/obo/HP_6000984	Coved type ST segment elevation	http://purl.obolibrary.org/obo/HP_0012251	ST segment elevation		An ST-segment elevation of at least 2 mm in at least one right precordial lead (V1 to V3), followed by an r'-wave and a concave or straight ST segment. The descending ST segment crosses the isoelectric line and is followed by a negative and symmetric T-wave.
http://purl.obolibrary.org/obo/HP_6000985	Saddle-back type ST segment elevation	http://purl.obolibrary.org/obo/HP_0012251	ST segment elevation		An ST-segment elevation of at least 0.5 mm (generally at least 2 mm in V2) in at least one right precordial lead (V1 to V3), followed by a convex ST. The r'-wave may or may not overlap the J point, but it has a slow downward slope. The ST segment is followed by a positive T-wave in V2 and is of variable morphology in V1.
http://purl.obolibrary.org/obo/HP_6000986	Substantially elevated circulating ethanol concentration	http://purl.obolibrary.org/obo/HP_0410172	Blood xenobiotic		A blood concentration of ethanol that is consistent with alcohol intoxication, generally assumed to be 0.0800 g/dL or higher.
http://purl.obolibrary.org/obo/HP_6000987	Tortuous appearance of the stomach	http://purl.obolibrary.org/obo/HP_0002577	Abnormal stomach morphology		Abnormal twisting or winding of the stomach.
http://purl.obolibrary.org/obo/HP_6000988	Cochlear nerve aplasia	http://purl.obolibrary.org/obo/HP_0011396	Abnormality of the cochlear nerve		A developmental defect causing an absence of the cochlear nerve resulting in sensorineural hearing loss.
http://purl.obolibrary.org/obo/HP_6000989	Slit-like lateral ventricle	http://purl.obolibrary.org/obo/HP_0030047	Abnormal lateral ventricle morphology		Abnormally small lateral ventricle with a slit-like appearance.
http://purl.obolibrary.org/obo/HP_6000990	Fetal methamphetamine exposure	http://purl.obolibrary.org/obo/HP_0034756	Fetal exposure history		A history of exposure during pregnancy (including during the period of conception) of the mother of a fetus or child to methamphetamine.
http://purl.obolibrary.org/obo/HP_6000991	Elevated circulating 4-hydroxybutyric acid concentration	http://purl.obolibrary.org/obo/HP_0033417	Elevated circulating hydroxybutyric acid concentration		Concentration of 4-hydroxybutyric acid in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000992	Elevated urinary 2,4-dihydroxybutyric acid level	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		The amount of 2,4-dihydroxybutyric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6000993	Pupillary hypersensitivity to parasympathomimetic agents	http://purl.obolibrary.org/obo/HP_0007686	Abnormal pupillary function		A higher than normal tendency of parasympathomimetic agents to induce miosis.
http://purl.obolibrary.org/obo/HP_6000994	Lack of pupillary response to hydroxyamphetamine	http://purl.obolibrary.org/obo/HP_0007686	Abnormal pupillary function		4-hydroxyamphetamine is used in eye drops to dilate the pupil, e.g.., to induce mydriasis for fundus examinations. This term refers to a lack of response of the pupil to topical application of 4-hydroxyamphetamine.
http://purl.obolibrary.org/obo/HP_6000995	Subcortical U fiber lesion	http://purl.obolibrary.org/obo/HP_0010993	Abnormal cerebral subcortex morphology		Abnormal morphology of subcortical U fibers, typically as assessed by abnromal intensity on magnetic resonance imaging of the brain.
http://purl.obolibrary.org/obo/HP_6000996	Intraspinal extradural lipoma	http://purl.obolibrary.org/obo/HP_6000590	Spinal lipoma		A lipoma (a benign encapsulated mass with lobulated mature adipose tissue enclosed by fibrous tissue) located within the spine but outside of the dura mater.
http://purl.obolibrary.org/obo/HP_6000997	Intranasal mass	http://purl.obolibrary.org/obo/HP_0010640	Abnormal nasal cavity morphology		An abnormal enlargement or swelling localized to the nasal cavity. The word mass is usually used at an early stage of the diagnostic workup before the precise nature of the swelling has been determined.
http://purl.obolibrary.org/obo/HP_6000998	Liver rupture	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Subcapsular hepatic rupture is characterized by the development of a hematoma, often quite large, beneath the liver capsule. An interval of days or hours may elapse between the time of injury and the first appearance of symptoms. A history of injury may be entirely lacking, or may be so unremarkable that it is elicited only by diligent interrogation. The hematoma tends to increase in size.
http://purl.obolibrary.org/obo/HP_6000999	Elevated urinary mandelic acid	http://purl.obolibrary.org/obo/HP_0033303	Elevated urinary monocarboxylic acid level		The amount of mandelic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001000	Elevated urine malic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The amount of malic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001001	Elevated urine 3-hydroxysebacic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of 3-hydroxysebacic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001002	Elevated urinary vanillactic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of vanillactic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001003	Elevated urine 4,5-dihydroxyhexanoic acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		The amount of 4,5-dihydroxyhexanoic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001004	Elevated urine hydroxyphenyllactic acid level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of hydroxyphenyllactic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001005	Positive gastric CMV intranuclear inclusions	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Demonstration of the presence of cytomegalovirus in the stomach by means of a method such as in-situ hybridization.
http://purl.obolibrary.org/obo/HP_6001006	Elevated urine dihydroxycholestanoic acid level	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		The amount of dihydroxycholestanoic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001007	Elevated urinary bile alcohol level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		The amount of bile alcohol in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001008	Elevated urine glucose tetrasaccharide level	http://purl.obolibrary.org/obo/HP_0010471	Oligosacchariduria		The amount of glucose tetrasaccharide in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001009	Increased urine 4-hydroxy-2-oxoglutarate level	http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria		The amount of 4-hydroxy-2-oxoglutarate in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001010	Inability to protrude lips	http://purl.obolibrary.org/obo/HP_0030319	Weakness of facial musculature		Lack of ability to purse or pucker the lips.
http://purl.obolibrary.org/obo/HP_6001011	Wet voice	http://purl.obolibrary.org/obo/HP_0001608	Abnormality of the voice		Wet voice is a perceptual vocal quality that is gurgly or liquid sounding and is due to the voice being produced through moisture. It is commonly used as an indicator of penetration and/or aspiration in clinical swallowing assessments and bedside screening tests.
http://purl.obolibrary.org/obo/HP_6001012	Erythema marginatum	http://purl.obolibrary.org/obo/HP_0010783	Erythema		An erythematous (pink-red, depending on the skin color of the affected individual) macule that spreads peripherally and coalesces to form polycyclic or serpentine patches or plaques. Lesions occur in crops over days to weeks and are evanescent. The rate of migration is 2 to 12 mm over a period of a few hours. Erythema marginatum tends to affect the trunk more than the extremities and to not be accompanied by pruritus.
http://purl.obolibrary.org/obo/HP_6001013	Mechanic's hands	http://purl.obolibrary.org/obo/HP_0010765	Palmar hyperkeratosis		Mechanic's hands are fissured, erythematous, hyperkeratotic eruptions on the hands, resembling the type of occupational dermatosis said to resemble the hands of a manual laborer. The lesions are classically on the lateral edges of the fingers and thumbs, largely sparing the palmar, and dorsal aspects of the digits.
http://purl.obolibrary.org/obo/HP_6001014	Hiker's feet	http://purl.obolibrary.org/obo/HP_0007556	Plantar hyperkeratosis		Hyperkeratotic scaly fissured plaques on the fingers/palms or soles, generally more evident on the lateral aspect of index fingers.
http://purl.obolibrary.org/obo/HP_6001015	Anti-HLA-DQ antibody positivity	http://purl.obolibrary.org/obo/HP_0034018	Anti-class II HLA antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen (HLA-DQ). DQ is one of several antigens involved in antibody-mediated rejection of organ transplants.
http://purl.obolibrary.org/obo/HP_6001016	Inappropriate normal or low erythropoietin	http://purl.obolibrary.org/obo/HP_0034442	Abnormal circulating erythropoietin concentration		Erythropoietin is produced and released into the blood by the kidneys in response to hypoxemia, and would normally be expected to increase with decreasing hemoglobin levels. This term applies if the increase fails to occur, as may be seen in conditions including chronic kidney disease.
http://purl.obolibrary.org/obo/HP_6001017	Rapid gastric emptying	http://purl.obolibrary.org/obo/HP_0030896	Abnormal gastrointestinal transit time		A condition in which food moves through the stomach into the small intestine at an abnormally fast rate.
http://purl.obolibrary.org/obo/HP_6001018	Mediastinal lymph node calcification	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		Abnormal deposition of calcium in mediastinal lymph nodes.
http://purl.obolibrary.org/obo/HP_6001019	Eggshell calcification of lymph nodes	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		Eggshell calcification refers to fine calcification seen at the periphery of a mass and usually relates to lamellar lymph node calcification.
http://purl.obolibrary.org/obo/HP_6001020	Knee joint effusion	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		Abnormal accumulation of fluid within the knee joint or around the knee. Symptoms maye include, pain, swelling, and stiffness.
http://purl.obolibrary.org/obo/HP_6001021	Subcutaneous emphysema	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Skin emphysema/Subcutaneous emphysema occurs when gas or air accumulates and seeps under the skin, where normally no gas should be present. While the presence of air in subcutaneous or mediastinal tissue is not dangerous in itself, prompt recognition of the underlying cause is essential.
http://purl.obolibrary.org/obo/HP_6001022	Elevated bone scintigraphy uptake	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Bone scintigraph is performed with technetium 99m-labeled diphosphonates. The uptake of these radiopharmaceuticals depicts osteoblastic activity and regional blood flow to bone.
http://purl.obolibrary.org/obo/HP_6001023	Diminished long-chain-enoyl-CoA hydratase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of long-chain-enoyl-CoA hydratase (EC 4.2.1.74) as measured in cultured fibroblasts is below the limits of normal.
http://purl.obolibrary.org/obo/HP_6001024	Diminished acetyl-CoA C-acyltransferase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Concentration or activity of acetyl-CoA C-acyltransferase (EC 2.3.1.16) as measured in cultured fibroblasts is below the limits of normal. This enzyme catalyzes the reaction acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA. It is also known as 3-ketoacyl-CoA thiolase and beta-ketothiolase.
http://purl.obolibrary.org/obo/HP_6001025	Pathological inclusion body	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		Pathological inclusion bodies are are composed of glycogen, proteins, nucleic acids, lipids, hemosiderin, and calcium, that accumulate as metabolic by-products, catabolic products of macromolecular complexes, or in the context of cell injury.
http://purl.obolibrary.org/obo/HP_6001026	Reduced epidermal collagen IV alpha 5 chain staining	http://purl.obolibrary.org/obo/HP_0031512	Abnormal cutaneous collagen fibril morphology		Diminished or absent collagen alpha5(IV) chain staining pattern in the epidermal basement membrane.
http://purl.obolibrary.org/obo/HP_6001027	Diminished glomerular basement membrane collagen IV alpha 3 chain staining	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Abnormal reduction in the amount of the alpha 3 chain of collagen IV in the basement membrane of the glomeruli of the kidney.
http://purl.obolibrary.org/obo/HP_6001028	Diminished glomerular basement membrane collagen IV alpha 4 chain staining	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Abnormal reduction in the amount of the alpha 4 chain of collagen IV in the basement membrane of the glomeruli of the kidney.
http://purl.obolibrary.org/obo/HP_6001029	Diminished glomerular basement membrane collagen IV alpha 5 chain staining	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		Abnormal reduction in the amount of the alpha 5 chain of collagen IV in the basement membrane of the glomeruli of the kidney.
http://purl.obolibrary.org/obo/HP_6001031	Cystine nephrolithiasis	http://purl.obolibrary.org/obo/HP_0000787	Kidney stone		A cystine stone is a type of kidney stone that is yellowish brown with a granular surface. They are observed in individuals with Cystinuria and tend to be of early onset, to occur repeatedly, and to be associated with urinary tract infections.
http://purl.obolibrary.org/obo/HP_6001032	Hepatic cystine accumulation	http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology		Accumulation of cystine in the liver.
http://purl.obolibrary.org/obo/HP_6001033	Bone marrow cystine accumulation	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		The presence of cystine crystals in bone marrow cells as demonstrated in a fresh bone marrow aspiration sample.
http://purl.obolibrary.org/obo/HP_6001035	Tubular jejunal duplication	http://purl.obolibrary.org/obo/HP_0005265	Abnormal jejunum morphology		A segment of the jejunum that runs parallel to the normal jejunum and communicates with the jejunal lumen at one or both ends.
http://purl.obolibrary.org/obo/HP_6001036	Left ventricular rupture	http://purl.obolibrary.org/obo/HP_0001711	Abnormal left ventricle morphology		A full thickness tear or breakage of the myocardium of the left ventricle.
http://purl.obolibrary.org/obo/HP_6001037	Punctate pontine perivascular enhancement	http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology		Multiple punctate (speckled, patchy spot-like) and/or curvilinear areas of gadolinium enhancement distributed around blood vessels in the pons.
http://purl.obolibrary.org/obo/HP_6001038	Intestinal worm	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Presence of one or more adult worms in the intestine as demonstrated by sonography or passage of a worm in the stool. On sonography, worms may appear as linear, echogenic structures within the intestines.
http://purl.obolibrary.org/obo/HP_6001039	Scrotal worm	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Demonstration of one or more worms in the scrotum. This finding can be appreciated by sonography, where echogenic, linear structures could be seen moving within the scrotum.
http://purl.obolibrary.org/obo/HP_6001040	Small intestinal adenoma	http://purl.obolibrary.org/obo/HP_0100833	Neoplasm of the small intestine		A small bowel tumor with adenomatous epithelium.
http://purl.obolibrary.org/obo/HP_6001041	Maternal retinal mottling	http://purl.obolibrary.org/obo/HP_0002686	Pregnancy history		Mottling (spots or blotches with different shades) of the retinal pigment epithelium in the mother of the index patient. Retinal mottling may indicate a mosaic X-linked inactivation state in the mother.
http://purl.obolibrary.org/obo/HP_6001042	Twisted gallbladder pedicle	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		A stretched conical-shaped structure found at the gallbladder neck with several linear echoes converging towards its tip. This finding is demonstrated by sonography and can indicate gallbladder volvulus.
http://purl.obolibrary.org/obo/HP_6001043	Cholecyst-enteric fistula	http://purl.obolibrary.org/obo/HP_0012437	Abnormal gallbladder morphology		Fistula between the gallbladder and the intestine.
http://purl.obolibrary.org/obo/HP_6001044	Dyschronometria	http://purl.obolibrary.org/obo/HP_0010524	Disturbed sensory perception		Impaired ability to accurately measure or estimate time intervals.
http://purl.obolibrary.org/obo/HP_6001045	History of recent intermittent breastfeeding	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		History of recently intermittent breastfeeding an infant (i.e., on and off).
http://purl.obolibrary.org/obo/HP_6001046	Breast cyst	http://purl.obolibrary.org/obo/HP_0031093	Abnormal breast morphology		A benign, fluid-filled sac in the breast.
http://purl.obolibrary.org/obo/HP_6001047	Circumscribed	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance are well-defined and localized to a specific area.
http://purl.obolibrary.org/obo/HP_6001048	Lobulated	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that displays multiple indentations and/or elevations producing an irregular surface contour.
http://purl.obolibrary.org/obo/HP_6001049	Spiculated	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality with irregular, radiating, or spiky edges.
http://purl.obolibrary.org/obo/HP_6001050	Whorled	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality whose distribution and appearance resembles series of a concentric circles or spirals.
http://purl.obolibrary.org/obo/HP_6001051	Delta brush pattern on EEG	http://purl.obolibrary.org/obo/HP_0002353	EEG abnormality		Delta brushes are transient patterns characterised by a slow delta wave with superimposed fast activity.
http://purl.obolibrary.org/obo/HP_6001052	Tibiotalar synostosis	http://purl.obolibrary.org/obo/HP_0005929	Synostosis involving the tibia		Fusion of the junction between the distal tibia, fibula and the talus.
http://purl.obolibrary.org/obo/HP_6001053	Vertebra plana	http://purl.obolibrary.org/obo/HP_0002953	Vertebral compression fracture		he term given when a vertebral body has lost almost its entire height anteriorly and posteriorly, representing a very advanced compression fracture.
http://purl.obolibrary.org/obo/HP_6001054	Intoeing	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		An abnormal gait caused by a rotational variation anywhere in the lower extremity that causes the foot to point inward, instead of pointing straight ahead or outward, when walking or running.
http://purl.obolibrary.org/obo/HP_6001055	Palpable thrill on extremity	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		A vibration felt upon palpation of a blood vessel over an extremity.
http://purl.obolibrary.org/obo/HP_6001056	Out-toeing	http://purl.obolibrary.org/obo/HP_0001288	Gait disturbance		The feet turn excessively outward when walking, caused by a rotational variation in the leg.
http://purl.obolibrary.org/obo/HP_6001057	Ankle dislocation	http://purl.obolibrary.org/obo/HP_0030311	Lower extremity joint dislocation		An abnormal separation between the talo-tibial joint.
http://purl.obolibrary.org/obo/HP_6001058	Anti-neuronal intermediate filament antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neuronal intermediate filament.
http://purl.obolibrary.org/obo/HP_6001059	Anti-DREBRIN antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the serum that react against dendritic spine scaffolding protein Drebrin.
http://purl.obolibrary.org/obo/HP_6001060	Anti-lipoprotein lipase autoantibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-lipoprotein lipase.
http://purl.obolibrary.org/obo/HP_6001061	Anti-apolipoprotein CII autoantibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies in the blood circulation that react against apoCII.
http://purl.obolibrary.org/obo/HP_6001062	Eosinophilic neuronal inclusion bodies	http://purl.obolibrary.org/obo/HP_0012757	Abnormal neuron morphology		The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neurons that stain with eosin, a red or pink dye.
http://purl.obolibrary.org/obo/HP_6001063	Sweaty foot-like odor	http://purl.obolibrary.org/obo/HP_0500001	Body odor		A characteristic smell said to resemble the odor of dirty socks.
http://purl.obolibrary.org/obo/HP_6001065	Hair shaft lesion	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Applies to an abnormality that is located on hair shafts.
http://purl.obolibrary.org/obo/HP_6001066	Prolonged use of tightly fitting footwear	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of use of tightly fitting shoes for a long period of time.
http://purl.obolibrary.org/obo/HP_6001067	Triggered by high protein intake	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		Applies to a sign or symptom that is provoked or brought about ingestion of high quantities of protein.
http://purl.obolibrary.org/obo/HP_6001068	Thickened tricuspid valve cusp	http://purl.obolibrary.org/obo/HP_0001702	Abnormal tricuspid valve morphology		An abnormally increased thickness of a leaflet of the tricuspid valve.
http://purl.obolibrary.org/obo/HP_6001069	Displaced anterior fontanelle	http://purl.obolibrary.org/obo/HP_0000236	Abnormal anterior fontanelle morphology		Abnormal shifting of the anterior fontanelle fropm its normal central position.
http://purl.obolibrary.org/obo/HP_6001070	Subdural hygroma	http://purl.obolibrary.org/obo/HP_0010651	Abnormal meningeal morphology		Accumulation of cerebral spinal fluid in the subdural space.
http://purl.obolibrary.org/obo/HP_6001071	Incus ankylosis	http://purl.obolibrary.org/obo/HP_0011453	Abnormal incus morphology		Incus ankylosis refers to congenital or acquired fixation of the incus, which is associated with conductive hearing resulting from impairment of the sound-conduction mechanism (the external auditory canal, tympanic membrane, and/or middle-ear ossicles).
http://purl.obolibrary.org/obo/HP_6001072	Excessive diet restriction	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A tendency to reject a variety of foods and/or to eat a restricted range of foods.
http://purl.obolibrary.org/obo/HP_6001073	Left ventricular apical dyskinesis	http://purl.obolibrary.org/obo/HP_0031482	Abnormal regional left ventricular contraction		Dyskinesis is used to describe ventricular muscle segments that bulge outside the left ventricular cavity during systole, as opposed to contracting inwards with the rest of the segments.
http://purl.obolibrary.org/obo/HP_6001074	Longitudinal erythronychia	http://purl.obolibrary.org/obo/HP_0001597	Abnormal nail morphology		A longitudinal red band extending from the proximal nail fold or lunula to the distal nail plate.
http://purl.obolibrary.org/obo/HP_6001075	Exacerbated by exposure to sunlight	http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication		Applied to a sign or symptom that is worsened by exposure to sunlight.
http://purl.obolibrary.org/obo/HP_6001076	Exacerbated by heat	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is made worse by exposure to heat (high ambient temperatures).
http://purl.obolibrary.org/obo/HP_6001077	Exacerbated by excessive sweating	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is made worse by excessive sweating.
http://purl.obolibrary.org/obo/HP_6001078	Malignant pleural effusion	http://purl.obolibrary.org/obo/HP_0002103	Abnormal pleura morphology		The accumulation of a significant amount of exudate in the pleural space, accompanied by the presence of malignant cells or tumour tissue.
http://purl.obolibrary.org/obo/HP_6001079	Inappropriately low urine osmolality following challenge	http://purl.obolibrary.org/obo/HP_0033358	Abnormal urine osmolality		In diabetes insipidus, affected individuals produce large quantities of dilute urine. In nephrogenic DI, the kidneys do not respond to vasopressin. In a water deprivation test or with administration of exogenous vasopressin, the osmolaltiy of the urine does not increase as normally.
http://purl.obolibrary.org/obo/HP_6001080	Reduced urine tetrahydrocortisol plus 5-alpha-THF to tetrahydrocortisone ratio	http://purl.obolibrary.org/obo/HP_0012029	Abnormal urine steroid level		Abnormally low ratio of tetrahydrocortisol (THF) plus 5-alpha-THF to tetrahydrocortisone (THE).
http://purl.obolibrary.org/obo/HP_6001081	Elevated urinary 2,4-dihydroxyglutarate level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The amount of 2,4-dihydroxyglutarate in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001082	Abnormal urine D-xylose test	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		An abnormal result of the xylose absorption test that is used to assess the ability of the intestines to absorb D-xylose. D-xylose is a five-carbon monosaccharide found in some plants. The patient drinks a solution containing a specific amount of D-xylose and the concentration of xylose is measured in the blood circulation and then in the urine. A low amount of D-xylose indicates reduced small intestinal absorbtion.
http://purl.obolibrary.org/obo/HP_6001083	Cerebral hemisphere mass lesion	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		An abnormal growth or accumulation of tissue in a hemisphere of the cerebrum. Typically a mass is an initial finding that will lead to additional workup.
http://purl.obolibrary.org/obo/HP_6001084	T2-hyperintense putaminal rim	http://purl.obolibrary.org/obo/HP_0031982	Abnormal putamen morphology		Increased signal on T2 magnetic resonance imaging characterized by a linear region of high signal surrounding the lateral aspect of the putamen at 1.5 Tesla.
http://purl.obolibrary.org/obo/HP_6001085	Posterior fossa mass lesion	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		An abnormal growth or accumulation of tissue in the posterior fossa, affecting the cerebellum or fourth ventricle. Typically a mass is an initial finding that will lead to additional workup.
http://purl.obolibrary.org/obo/HP_6001086	Irregular RR interval	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		Abnormal increased variability in the timing between consecutive R-waves on an electrocardiogram.
http://purl.obolibrary.org/obo/HP_6001087	Irregular P-P interval	http://purl.obolibrary.org/obo/HP_0003115	Abnormal EKG		Abnormally increased variability in the timing between consecutive P-waves on an electrocardiogram.
http://purl.obolibrary.org/obo/HP_6001088	Fungal hair infection	http://purl.obolibrary.org/obo/HP_0430030	Positive infectious agent test		Demonstration of fungi growing on hair by a method such as microscopy of hairs mounted on slides with 10% potassium hydroxide.
http://purl.obolibrary.org/obo/HP_6001089	Long hairstyle	http://purl.obolibrary.org/obo/HP_0032443	Past medical history		A past medical history of having long, full hair.
http://purl.obolibrary.org/obo/HP_6001090	Conjunctival subepithelial fibrosis	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		fine white linear scars under intact conjunctival epithelium. This scarring appears in areas of previous conjunctival ulceration or pseudomembrane formation, weeks to months after the insult is healed.
http://purl.obolibrary.org/obo/HP_6001091	Conjunctival fornix foreshortening	http://purl.obolibrary.org/obo/HP_0000502	Abnormal conjunctiva morphology		Abnormal reduction in depth of the fornix of the conjunctiva. The fornix is the area where the conjunctiva folds back upon itself, thereby creating a recessed space.
http://purl.obolibrary.org/obo/HP_6001092	Strong ultraviolet light exposure	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		History of exposure to ultraviolet light, such as may be encountered with outdoor activities, living near equator, radiation.
http://purl.obolibrary.org/obo/HP_6001093	Exposure to vaginal douching	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of intravaginal cleansing with a liquid solution for personal hygiene or aesthetic reasons.
http://purl.obolibrary.org/obo/HP_6001094	Exposure to oily lotions or creams	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of applying oily lotions or creams to the skin.
http://purl.obolibrary.org/obo/HP_6001095	Elevated circulating pristanic acid concentration following branched-chain fatty acid ingestion	http://purl.obolibrary.org/obo/HP_0010964	Abnormal circulating long-chain fatty-acid concentration		Concentration of pristanic acid in the blood circulation above the upper limit of normal. This finding can be observed in Zellweger syndrome. Note that branched-chain fatty acid accumulation depends on dietary intake of phytanic acid, which is minimal in formula- and breast-fed infants. Thus, phytanic and pristanic acid levels are normal in a neonate with Zellweger spectrum disorder.
http://purl.obolibrary.org/obo/HP_6001096	Decreased CD4+ T cell ZAP-70 protein expression	http://purl.obolibrary.org/obo/HP_0002843	Abnormal T cell morphology		Reduction in the level of ZAP-70 protein CD4-positive T cells.
http://purl.obolibrary.org/obo/HP_6001097	Dorsal flexion contracture of the ankle	http://purl.obolibrary.org/obo/HP_0034677	Ankle contracture		A type of contracture in which the dorsal flexion muscles of the ankle are contracted.
http://purl.obolibrary.org/obo/HP_6001098	Metaphyseal undermodelling	http://purl.obolibrary.org/obo/HP_0000944	Abnormal metaphysis morphology		Lack of the normal diaphyseal constriction (thinning of long bones toward the midshaft area) giving the submetaphyseal areas an abnormally wide appearance.
http://purl.obolibrary.org/obo/HP_6001099	Iliac vein compression	http://purl.obolibrary.org/obo/HP_0002624	Abnormal venous morphology		Compression of the common iliac vein against the spine by the contralateral common iliac artery.
http://purl.obolibrary.org/obo/HP_6001100	Positive serum amyloid P scintigraphy	http://purl.obolibrary.org/obo/HP_0011034	Amyloid deposition		Detection of abnormal amyloid deposits in the body by 123I-labeled serum amyloid P component (SAP) scintigraphy.
http://purl.obolibrary.org/obo/HP_6001101	Crossed brainstem sign	http://purl.obolibrary.org/obo/HP_0011442	Abnormal central motor function		Motor and/or sensory cranial nerve findings ipsilateral to the lesion, and at the same time motor and/or sensory findings on the contralateral side of the body.
http://purl.obolibrary.org/obo/HP_6001102	Inability to puff cheeks	http://purl.obolibrary.org/obo/HP_0030319	Weakness of facial musculature		Reduced ability to inflate the cheeks by blowing air into them while keeping the lips closed.
http://purl.obolibrary.org/obo/HP_6001103	Entoptic phenomenon	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		Visual sensations caused by changes within the eye itself, rather than by the normal light stimulation process. Entoptic phenomena are classified in the syndrome as floaters, blue field entoptic phenomenon, photopsia and self-light of the eye.
http://purl.obolibrary.org/obo/HP_6001104	Abnormal vestibulo-spinal reflex	http://purl.obolibrary.org/obo/HP_0001751	Abnormal vestibular function		An abnormality of the vestibulospinal (VS) reflexes, which contribute to the control of postural orientation. In this task, they continuously collaborate with reflexes elicited by stimulation of visual and somatosensory receptors. Labyrinthine receptors are sensitive to modifications (i) of the head position with respect to the earth vertical or (ii) of the angular/linear velocity of head motion in space. This information can be used to monitor deviations from the maintained body position.
http://purl.obolibrary.org/obo/HP_6001105	Positive probe-to-bone test	http://purl.obolibrary.org/obo/HP_0032674	Cutaneous wound		An abnormal result of the probe-to-bone (PTB) test. The PTB test is performed by inserting a sterile, metal surgical probe into the ulcer and is positive if a hard, gritty surface is felt inside. For large wounds, this may require gentle exploration of the wound with the probe.
http://purl.obolibrary.org/obo/HP_6001106	Exposure to repetitive hand impact	http://purl.obolibrary.org/obo/HP_4000110	Exposure history		A history of exposure to repetitive impact on palm or hand, such as working with a jackhammer.
http://purl.obolibrary.org/obo/HP_6001107	Fractured scaphoid bone	http://purl.obolibrary.org/obo/HP_0041248	Fractured carpal bone		A partial or complete breakage of the scaphoid bone.
http://purl.obolibrary.org/obo/HP_6001108	Local anesthetic ineffectiveness	http://purl.obolibrary.org/obo/HP_0001311	Abnormal nervous system electrophysiology		Resistance to the effects of local anaesthesia, with delayed onset or failure of local anesthetics to incude numbness or relieve pain.
http://purl.obolibrary.org/obo/HP_6001109	Palmoplantar location	http://purl.obolibrary.org/obo/HP_0012838	Localized		Applied to lesions whose distribution is confined or restricted to the palms of the hands and soles of the feet.
http://purl.obolibrary.org/obo/HP_6001110	Oral mucosa plaque	http://purl.obolibrary.org/obo/HP_0011830	Abnormal oral mucosa morphology		A raised, flat-topped lesion with a diameter of one centimeter or more that is located in the mucosa of the mouth.
http://purl.obolibrary.org/obo/HP_6001111	Positive saliva rabies nucleic acid test	http://purl.obolibrary.org/obo/HP_6000579	Positive oropharangeal infectious agent test		Detection of rabies nucleic acid in saliva by a method such as polymerase chain reaction.
http://purl.obolibrary.org/obo/HP_6001112	Elevated tissue arylsulfatase A activity	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Activity of arylsulfatase A (EC 3.1.6.8) above the upper limit of normal. The activity can be measured in multiple tissues including culutured fibroblasts and leukocytes or in the blood circulation.
http://purl.obolibrary.org/obo/HP_6001113	Elevated circulating methysterol concentration	http://purl.obolibrary.org/obo/HP_0003119	Abnormal circulating lipid concentration		The concentration of a methysterol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_6001114	Elevated urinary adipic acid	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The amount of adipic acid in the urine, normalized for urine concentration, is above the upper limit of normal. Adipic acid is an alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane.
http://purl.obolibrary.org/obo/UBERON_8450003	embryonic craniocervical region	http://purl.obolibrary.org/obo/UBERON_0007811	craniocervical region		A craniocervical region that is part of an embryo.
http://purl.obolibrary.org/obo/GO_0140139	solid phase of basement membrane	http://purl.obolibrary.org/obo/GO_0030312	external encapsulating structure		The solid compartment of the basement membrane ECM, including a specific subset of basement membrane collagens and basement membrane glycoproteins like laminins or nidogens.
http://purl.obolibrary.org/obo/GO_0140143	collagenous component of basement membrane	http://purl.obolibrary.org/obo/GO_0030312	external encapsulating structure		Collagenous component of basement membrane ECMs, including collagen IV and other types of collagen specifically expressed in basement membrane.
http://purl.obolibrary.org/obo/GO_0140149	non-collagenous component of interstitial matrix	http://purl.obolibrary.org/obo/GO_0030312	external encapsulating structure		The non-collagenous component of interstitial extracellular matrices, including glycoprotein like fibronectin and elastin.
http://purl.obolibrary.org/obo/GO_0140151	solid phase of interstitial matrix	http://purl.obolibrary.org/obo/GO_0030312	external encapsulating structure		The solid compartment of the interstitial matrix, including interstitial collagens such as fibrillar and fibril-associated collagens and non-collagenous glycoproteins like fibronectin and elastin.
http://purl.obolibrary.org/obo/GO_0140152	collagenous component of interstitial matrix	http://purl.obolibrary.org/obo/GO_0030312	external encapsulating structure		Main components of the interstitial matrix solid phase, including fibrillar and fibril-associated collagens.
http://purl.obolibrary.org/obo/GO_0140154	chicken-wire-like collagen network	http://purl.obolibrary.org/obo/GO_0098645	complex of network-forming collagens		Network-forming collagens can either form a chicken-wire-like network or a hexagonal network. Collagen type IV forms a chicken-wire-like structure and is found in the basement membrane.
http://purl.obolibrary.org/obo/HP_0031094	Abnormal breast physiology	http://purl.obolibrary.org/obo/HP_0000769	Abnormality of the breast		Any anomaly of the function of the breast.
http://purl.obolibrary.org/obo/HP_0031109	Agalactia	http://purl.obolibrary.org/obo/HP_0031094	Abnormal breast physiology		Failure of secretion of milk following childbirth associated with an inability to breastfeed an infant.
http://purl.obolibrary.org/obo/HP_0031110	Twin-to-twin transfusion	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		As a result of sharing a single placenta, the blood supplies of monochorionic twin fetuses can become connected, so that they share blood circulation: although each fetus uses its own portion of the placenta, the connecting blood vessels within the placenta allow blood to pass from one twin to the other.Depending on the number, type and direction of the interconnecting blood vessels (anastomoses), blood can be transferred disproportionately from one twin (the donor) to the other (the recipient). This state of transfusion causes the donor twin to have decreased blood volume, retarding the donor's development and growth. The blood volume of the recipient twin is increased, which can strain the fetus's heart and eventually lead to heart failure.
http://purl.obolibrary.org/obo/HP_0031188	Genital edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		A buildup of fluid that causes swelling in the soft tissues of the genital area.
http://purl.obolibrary.org/obo/HP_0031189	Wrist drop	http://purl.obolibrary.org/obo/HP_0003484	Upper limb muscle weakness		A condition in which the affected individual cannot extend the wrist, which hangs flaccidly.
http://purl.obolibrary.org/obo/HP_0031190	Superficial dermal perivascular inflammatory infiltrate	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Numerous lymphocytes surrounding blood vessels in the superficial part of the dermis.
http://purl.obolibrary.org/obo/HP_0031191	Deep dermal perivascular inflammatory infiltrate	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		Numerous lymphocytes surrounding blood vessels in the deep part of the dermis.
http://purl.obolibrary.org/obo/HP_0031192	Abnormal morphology of left ventricular trabeculae	http://purl.obolibrary.org/obo/HP_0030681	Abnormal morphology of myocardial trabeculae		Any structural anomaly of the muscular columns which project from the inner surface of the left ventricle of the heart (cardiac trabeculae, trabeculae carneae).
http://purl.obolibrary.org/obo/HP_0031193	Abnormal morphology of right ventricular trabeculae	http://purl.obolibrary.org/obo/HP_0030681	Abnormal morphology of myocardial trabeculae		Any structural anomaly of the muscular columns which project from the inner surface of the right ventricle of the heart (cardiac trabeculae, trabeculae carneae).
http://purl.obolibrary.org/obo/HP_0031194	Increased density of left ventricular trabeculae	http://purl.obolibrary.org/obo/HP_0031192	Abnormal morphology of left ventricular trabeculae		An increased density (number and tightness) of the muscular columns which project from the inner surface of the left ventricles of the heart (cardiac trabeculae, trabeculae carneae).
http://purl.obolibrary.org/obo/HP_0031195	Apical hypertrabeculation of the left ventricle	http://purl.obolibrary.org/obo/HP_0031192	Abnormal morphology of left ventricular trabeculae		An increased number and density of the trabeculae in the apex (tip) of the left ventricle.
http://purl.obolibrary.org/obo/HP_0031196	Thin myocardium compact layer	http://purl.obolibrary.org/obo/HP_0031192	Abnormal morphology of left ventricular trabeculae		Reduced thickness of the outer, dense layer of the myocardium.
http://purl.obolibrary.org/obo/HP_0031197	Cellular urinary casts	http://purl.obolibrary.org/obo/HP_0012615	Cylindruria		A type of urinary cast composed of cells incorporated in a protein matrix. The cells can be those found in the urinary sediment (erythrocytes, leuklocytes, renal tubular epithelial cells).
http://purl.obolibrary.org/obo/HP_0031198	Renal tubular epithelial cell casts	http://purl.obolibrary.org/obo/HP_0031197	Cellular urinary casts		A type of cellular urinary cast composed of renal tubular epithelial cells.
http://purl.obolibrary.org/obo/HP_0031199	Acellular urinary casts	http://purl.obolibrary.org/obo/HP_0012615	Cylindruria		A type of urinary cast composed of a proteinaceous matrix without a substantial number of cells.
http://purl.obolibrary.org/obo/HP_0031200	Hyaline casts	http://purl.obolibrary.org/obo/HP_0031199	Acellular urinary casts		A type of acellular urinary cast that are composed only of Tamm-Horsfall glycoprotein, a fact which explains their low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends.
http://purl.obolibrary.org/obo/HP_0031201	Granular casts	http://purl.obolibrary.org/obo/HP_0031199	Acellular urinary casts		A type of acelluar casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented.
http://purl.obolibrary.org/obo/HP_0031202	Waxy casts	http://purl.obolibrary.org/obo/HP_0031199	Acellular urinary casts		A type of acellular urinary casts that display a melted wax (waxy) appearance, which gives them a high refractive index. They are frequently dark, with blunt extremities, indented and cracked edges and a large size, which is often several times that of other types of casts.
http://purl.obolibrary.org/obo/HP_0031203	Fatty casts	http://purl.obolibrary.org/obo/HP_0031199	Acellular urinary casts		A type of acellular urinary casts that contain lipid droplets, oval fat bodies or cholesterol crystals, and are often associated with the free forms of these elements. Their identification may require the use of polarized light microscopy, under which fatty particles embedded into the cast matrix appear as Maltese crosses.
http://purl.obolibrary.org/obo/HP_0031204	Bacterial cell casts	http://purl.obolibrary.org/obo/HP_0012615	Cylindruria		A type of urinary cast that contain bacteria. Bacterial casts can be difficult to identify and can be distinguished from other types of casts using phase contrast microscopy. Bacterial casts are diagnostic of acute pyelonephritis or intrinsic renal infection.
http://purl.obolibrary.org/obo/HP_0031205	Reduced lysosomal acid lipase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduction in the activity of lysosomal acid lipase (LAL) in the blood. Lysosomal lipase activity is measured. LAL hydrolyzes cholesteryl esters derived from cell internalization of plasma lipoproteins.
http://purl.obolibrary.org/obo/HP_0031206	Striatal T2 hyperintensity	http://purl.obolibrary.org/obo/HP_0007183	Focal T2 hyperintense basal ganglia lesion		Abnormally bright T2 signal from the striatum on brain magnetic resonance imaging.
http://purl.obolibrary.org/obo/UBERON_0036217	coelomic fluid	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		A bodily fluid that is located in the coelom.
http://purl.obolibrary.org/obo/UBERON_0036242	post-embryonic notochord	http://purl.obolibrary.org/obo/UBERON_0002328	notochord		A notochord that has persisted beyond the embryonic stage.
http://purl.obolibrary.org/obo/UBERON_0036243	vaginal fluid	http://purl.obolibrary.org/obo/UBERON_0006314	bodily fluid		Fluid that lines the vaginal walls that consists of multiple secretions that collect in the vagina from different glands.
http://purl.obolibrary.org/obo/UBERON_0036262	uterine ligament	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		Any of the eight ligaments pertaining to the uterus including the anterior, posterior, lateral, sacro-uterine and round ligaments.
http://purl.obolibrary.org/obo/PATO_0045040	normal position	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A position which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045013	normal curvature	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A curvature which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045088	normal sensitivity of a process	http://purl.obolibrary.org/obo/PATO_0045073	normal process quality		A sensitivity of a process which is relatively normal.
http://purl.obolibrary.org/obo/PATO_0045066	normal susceptibility toward	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A susceptibility toward an external stimulus which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045010	normal concentration	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A concentration which is relatively normal or average.
http://purl.obolibrary.org/obo/PATO_0045086	normal occurrence	http://purl.obolibrary.org/obo/PATO_0045073	normal process quality		An occurrence which is relatively normal.
http://purl.obolibrary.org/obo/PATO_0045059	normal thickness	http://purl.obolibrary.org/obo/PATO_0045050	normal size		A thickness which is relatively normal or average
http://purl.obolibrary.org/obo/PATO_0045049	normal sensitivity toward	http://purl.obolibrary.org/obo/PATO_0045001	normal object quality		A sensitivity toward an external stimulus which is relatively normal or average
http://purl.obolibrary.org/obo/GO_0140244	regulation of translation at presynapse	http://purl.obolibrary.org/obo/GO_0140243	regulation of translation at synapse		Any process that regulates translation occurring at the presynapse.
http://purl.obolibrary.org/obo/HP_0032263	Increased blood pressure	http://purl.obolibrary.org/obo/HP_0030972	Abnormal systemic blood pressure		Abnormal increase in blood pressure. An individual measurement of increased blood pressure does not necessarily imply hypertension. In practical terms, multiple measurements are recommended to diagnose the presence of hypertension.
http://purl.obolibrary.org/obo/HP_0020074	Crystalluria	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		The presence of crystals in the urine.
http://purl.obolibrary.org/obo/HP_0020096	Recurrent streptococcal infections	http://purl.obolibrary.org/obo/HP_0002718	Recurrent bacterial infections		Increased susceptibility to streptococcal infections as manifested by recurrent episodes of streptococcal infections.
http://purl.obolibrary.org/obo/HP_0020100	Unusual fungal infection	http://purl.obolibrary.org/obo/HP_0032101	Unusual infection		An unusual fungal infection that is regarded as a sign of a pathological susceptibility to infection by a fungal agent.
http://purl.obolibrary.org/obo/HP_0025615	Abscess	http://purl.obolibrary.org/obo/HP_0032251	Abnormal immune system morphology		An abscess is a localized collection of purulent material surrounded by inflammation and granulation.
http://purl.obolibrary.org/obo/HP_0032309	Abnormal granulocyte count	http://purl.obolibrary.org/obo/HP_0011893	Abnormal leukocyte count		Abnormal increase or decrease of absolute number of granulocytes in the blood, per microliter, compared to a reference range for a given sex and age-group.
http://purl.obolibrary.org/obo/HP_0032311	Elevated circulating globulin concentration	http://purl.obolibrary.org/obo/HP_0032179	Abnormal circulating globulin concentration		The concentration of globulins in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0032368	Acidemia	http://purl.obolibrary.org/obo/HP_0004360	Abnormality of acid-base homeostasis		An abnormally low blood pH (usually defined as less than 7.35).
http://purl.obolibrary.org/obo/HP_0032416	Retinal microaneurysm	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		A localized dilation or outpouching of microvasculature formed due to disruption of the vessel wall of a retinal capillary blood vessel. The lesions present as small red dots with distinct margins and are not larger than a blood vessel width at the disk margin.
http://purl.obolibrary.org/obo/HP_0032445	Pulmonary cyst	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid.
http://purl.obolibrary.org/obo/HP_0032459	Abnormal phosphoribosylpyrophosphate synthetase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Any deviation from the normal level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.
http://purl.obolibrary.org/obo/HP_0032476	Abnormal circulating vitamin B6 concentration	http://purl.obolibrary.org/obo/HP_0004340	Abnormal circulating vitamin B concentration		An abnormal concentration of vitamin B6 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0025635	Ureteral polyp	http://purl.obolibrary.org/obo/HP_0100516	Neoplasm of the ureter		A growth protruding from the mucous membrane of the ureter. Ureteral polyps can be attached to the ureter by a broad base or a thin stalk.
http://purl.obolibrary.org/obo/HP_0025636	Endometritis	http://purl.obolibrary.org/obo/HP_0030126	Abnormal endometrium morphology		Inflammation of the inner lining of the uterus (endometrium).
http://purl.obolibrary.org/obo/HP_0025637	Vasospasm	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Narrowing of an artery due to constriction of the blood vessels.
http://purl.obolibrary.org/obo/HP_0025638	Elevated urinary N-butyrylglycine	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		An increased level of N-butyrylglycine in the urine.
http://purl.obolibrary.org/obo/HP_0025639	Increased urinary zinc level	http://purl.obolibrary.org/obo/HP_0025640	Abnormal urinary mineral level		An abnormally elevated amount of zinc in the urine, typically as assessed by a 24 hour urine collection.
http://purl.obolibrary.org/obo/HP_0025640	Abnormal urinary mineral level	http://purl.obolibrary.org/obo/HP_0003110	Abnormality of urine homeostasis		An abnormal concentration or amount of a mineral in the urine. Medically relevant minerals include calcium, phosphorus, potassium, sodium, chloride, magnesium, iron, zinc, iodine, chromium, copper, fluoride, molybdenum, manganese, and selenium.
http://purl.obolibrary.org/obo/HP_0025641	Elevated circulating glycolate concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		The concentration of glycolate in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0041049	Starch intolerance	http://purl.obolibrary.org/obo/HP_0002024	Malabsorption		An inability to digest starch.
http://purl.obolibrary.org/obo/CHEBI_155837	tripeptide zwitterion	http://purl.obolibrary.org/obo/CHEBI_60466	peptide zwitterion		A peptide zwitterion obtained from the tranfer of a proton from the carboxy group to the amino group of any tripeptide. It contains an equal number of positively-charged and negatively-charged functional groups. Major structure at pH 7.3.
http://purl.obolibrary.org/obo/HP_0033057	Decreased circulating terminal complement component concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9.
http://purl.obolibrary.org/obo/HP_0041078	Decreased immunoglobulin level in body fluid	http://purl.obolibrary.org/obo/HP_0041076	Abnormal immunoglobulin level in body fluid		An reduction from normal levels of immunoglobulins in body fluids, such as mucous.
http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration	http://purl.obolibrary.org/obo/HP_0003112	Abnormal circulating amino acid concentration		Any deviation from the normal concentration in the blood circulation of an alpha-amino acid that is not a member of the group of 23 proteinogenic amino acids.
http://purl.obolibrary.org/obo/HP_0033129	Abnormal shoulder physiology	http://purl.obolibrary.org/obo/HP_0034430	Abnormal joint physiology		Anopmalous function of the shoulder. The shoulder is a ball-and-socket joint that is made up of humerus, scapula and clavicle, which are connected by the sternoclavicular joint (SC), the acromioclavicular joint (AC), the glenohumeral joint (GH), and the scapulothoracic joint (ST). The GH, AC and SC joints link the upper extremity to the axial skeleton at the thorax and enable movement at the shoulder joint: flexion, extension, and rotation of the arm.
http://purl.obolibrary.org/obo/HP_0033137	Abnormal pulmonary alveolar system morphology	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		A structural abnormality of the pulmonary acinus, alveolar parenchyma, or alveoli.
http://purl.obolibrary.org/obo/HP_0033144	Abnormal circulating ceruloplasmin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of ceruloplasmin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033162	Abnormal urinary pyrimidine level	http://purl.obolibrary.org/obo/HP_0032572	Abnormal urinary nucleobase concentration		Any deviation from the normal amount of a pyrimidine compound in the urine. Pyrimidines and pyrimidine derivatives are compounds containing a pyrimidne ring, which is a six-member aromatic heterocycle which consists of two nitrogen atoms (at positions 1 and 3) and four carbon atoms. The nucleotides cytosine, thymine and uracil are pyrimidines.
http://purl.obolibrary.org/obo/HP_0033089	Branched-chain aminoaciduria	http://purl.obolibrary.org/obo/HP_0033100	Increased proteinogenic amino acid level in urine		An increased level of a branched chain family amino acid in the urine.
http://purl.obolibrary.org/obo/HP_0033091	Tyrosinuria	http://purl.obolibrary.org/obo/HP_0033090	Increased aromatic amino acid level in urine		An abnormally increased level of tyrosine in the urine.
http://purl.obolibrary.org/obo/HP_0033092	Increased urine succinate level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of succinate in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033094	Increased urine glutamate level	http://purl.obolibrary.org/obo/HP_0033093	Increased glutamine family amino acid level in urine		An increased concentration of glutamate in the urine.
http://purl.obolibrary.org/obo/HP_0033101	Elevated urine aconitic acid level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		An abnormally increased level of aconitic acid in the urine.
http://purl.obolibrary.org/obo/HP_0033102	Monkey wrench femoral neck	http://purl.obolibrary.org/obo/HP_0003367	Abnormal femoral neck morphology		The femoral neck region shows medial metaphyseal beaking and a significant enlargement of the lesser trochanter (with some enlargement also of the greater trochanter), producing a monkey wrench (Swedish key) configuration of the proximal femur. A monkey wrench refers to a type of adjustable wrench with one fixed and one adjustable jaw at right angles to a straight handle.
http://purl.obolibrary.org/obo/HP_0033103	Elevated circulating CHI3L1 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of CHI3L1 in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033104	Inappropriate absence of fever	http://purl.obolibrary.org/obo/HP_0004370	Abnormality of temperature regulation		Failure to develop fever in the presence of an infection that normally would be expected to elicit a febrile response.
http://purl.obolibrary.org/obo/HP_0033105	Interhypothalamic adhesion	http://purl.obolibrary.org/obo/HP_0012286	Abnormal hypothalamus morphology		An abnormal parenchymal band connecting the medial margins of the left and right hypothalami across the third ventricle.
http://purl.obolibrary.org/obo/HP_0033106	Elevated circulating D-dimer concentration	http://purl.obolibrary.org/obo/HP_0040224	Abnormality of fibrinolysis		An increased concentration of D-dimers, a marker of fibrin degradation, in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033110	Elevated circulating alpha-aminobutyric acid concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An abnormally increased level of alpa-aminobutyric acid in the blood circulation. Alpha-aminobutyric acid alpha-amino acid that is butyric acid bearing a single amino substituent located at position 2.
http://purl.obolibrary.org/obo/HP_0033111	3-hydroxyisovaleric aciduria	http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria		Concentration of 3-hydroxyisovaleric acid in the urine above the normal range.
http://purl.obolibrary.org/obo/HP_0033112	Elevated circulating apolipoprotein C-III concentration	http://purl.obolibrary.org/obo/HP_0033460	Elevated circulating apolipoprotein concentration		The concentration of apolipoprotein C-III in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033113	Gallop rhythm	http://purl.obolibrary.org/obo/HP_0031657	Abnormal heart sound		In the normal heart cycle, two heart sounds can be heard by auscultation per cycle: S1 and S2. A gallop rhythm refers to the presence of three or four heart sounds per cardiac cycle, which is said to resemble the gallop of a horse.
http://purl.obolibrary.org/obo/HP_0033114	Quadruple gallop rhythm	http://purl.obolibrary.org/obo/HP_0033113	Gallop rhythm		A type of gallop rhythm in which both the third and the fourth sounds are present.
http://purl.obolibrary.org/obo/HP_0033115	Elevated circulating tenascin-C concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of tenascin-C in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033116	Duodenal gastric metaplasia	http://purl.obolibrary.org/obo/HP_0002246	Abnormal duodenum morphology		Foci of gastric-type mucus-secreting cells interspersed between duodenal enterocytes. These foci of gastric epithelial cells contain Periodic acid-Schiff (PAS)-positive neutral mucin and lack a brush border.
http://purl.obolibrary.org/obo/HP_0033117	Duodenitis	http://purl.obolibrary.org/obo/HP_0002246	Abnormal duodenum morphology		Inflammation of the lining of the upper small intestine (duodenum).
http://purl.obolibrary.org/obo/HP_0033119	Elevated right ventricular systolic pressure	http://purl.obolibrary.org/obo/HP_0033118	Abnormal right ventricular function		Elevation of right ventricular systolic pressure (RVSP) above normal limits. In adults, RVSP is normally 20-30 mmHg.
http://purl.obolibrary.org/obo/HP_0033120	Nummular eczema	http://purl.obolibrary.org/obo/HP_0000964	Eczematoid dermatitis		A type of eczema characterized by pruritic coin-shaped patches on the skin. Nummular eczema most commonly occurs on the extremities, particularly the legs, but may occur anywhere on the trunk, hands, or feet
http://purl.obolibrary.org/obo/HP_0033121	Barking cough	http://purl.obolibrary.org/obo/HP_0012735	Cough		A cough with a characteristic sound that has been compared to a seal's bark.
http://purl.obolibrary.org/obo/HP_0033122	Absent P wave	http://purl.obolibrary.org/obo/HP_0031595	Abnormal P wave		The P wave that normally precedes each QRS complex by a fixed PR interval of 120 to 200 milliseconds is not present.
http://purl.obolibrary.org/obo/HP_0033123	Elevated circulating osteopontin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of osteopontin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033124	Elevated circulating sorbitol concentration	http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration		An concentration of sorbitol in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033125	Follicular lymphoma	http://purl.obolibrary.org/obo/HP_0012191	B-cell lymphoma		An indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement.
http://purl.obolibrary.org/obo/HP_0033126	Cutaneous necrosis	http://purl.obolibrary.org/obo/HP_0011355	Localized skin lesion		Skin and subcutaneous tissue necrosis (tissue death). Clinically, cutaneous necrosis may present as a painful and extremely tender black eschar (dead tissue found in a full-thickness wound) surrounded by dusky grey-red colored skin or as slough (dead tissue, usually cream or yellow in colour).
http://purl.obolibrary.org/obo/HP_0033128	Delayed ability to crawl	http://purl.obolibrary.org/obo/HP_0002194	Delayed gross motor development		A failure to achieve the ability to crawl at an appropriate developmental stage. Normal infant motor development is marked by a series of postural milestones including learning to crawl on hands and knees between the ages of 6 and 10 months.
http://purl.obolibrary.org/obo/HP_0033131	Renal medullary hyperechogenicity	http://purl.obolibrary.org/obo/HP_0033130	Abnormal renal echogenicity		Increased echogenecity of the medullary region of the kidney.
http://purl.obolibrary.org/obo/HP_0033132	Renal cortical hyperechogenicity	http://purl.obolibrary.org/obo/HP_0033130	Abnormal renal echogenicity		Increased echogenecity of the kidney cortex.
http://purl.obolibrary.org/obo/HP_0033134	Abdominal adhesions	http://purl.obolibrary.org/obo/HP_0001438	Abnormal abdomen morphology		Fibrous bands (i.e., bands of scar-like tissue) that span two or more intra-abdominal organs and/or the inner abdominal wall (i.e. peritoneal membrane).
http://purl.obolibrary.org/obo/HP_0033135	Hepatic infarction	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Hepatic infarction is defined as areas of coagulative necrosis from hepatocyte cell death caused by local ischemia. Liver infarctions appear as hypoechoic nonvascular regions on conventional and Doppler sonography.
http://purl.obolibrary.org/obo/HP_0033136	Lymph node abscess	http://purl.obolibrary.org/obo/HP_5210134	Unusual cholangitis		An inflamed lymph node that is filled with pus.
http://purl.obolibrary.org/obo/HP_0033138	Right atrial thrombus	http://purl.obolibrary.org/obo/HP_0025580	Abnormal right atrium morphology		A thrombus (i.e., a blood clot formed in situ within the vascular system) located in the right atrium of the heart.
http://purl.obolibrary.org/obo/HP_0033139	Elevated circulating uracil concentration	http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration		Concentration of uracil in the blood circulation is above the normal range.
http://purl.obolibrary.org/obo/HP_0033140	Blake's pouch cyst	http://purl.obolibrary.org/obo/HP_0000932	Abnormal posterior cranial fossa morphology		The presence of an upwardly displaced normal cerebellar vermis, normal appearance of the fastigium, tentorium and size of the cisterna magna.
http://purl.obolibrary.org/obo/HP_0033141	Severe SARS-CoV-2 infection	http://purl.obolibrary.org/obo/HP_0034317	Unusual viral infection		Unusually severe clinical course of SARS-CoV-2 infection, manifested clinically by features such as dyspnea and hypoxia with diffuse bilateral ground-glass opacities of the lungs on computed tomographic scan with progressive respiratory insufficiency necessitating oxygen supplementation or mechanical ventilation.
http://purl.obolibrary.org/obo/HP_0033142	Long nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		Increased superior-inferior length of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose.
http://purl.obolibrary.org/obo/HP_0033143	Jejunitis	http://purl.obolibrary.org/obo/HP_0005265	Abnormal jejunum morphology		Inflammation of the lining of the middle section of the small intestine.
http://purl.obolibrary.org/obo/HP_0033145	Elevated circulating ceruloplasmin concentration	http://purl.obolibrary.org/obo/HP_0033144	Abnormal circulating ceruloplasmin concentration		The concentration of ceruloplasmin in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033146	Elevated circulating methylsuccinic acid concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		Increased concentration of methylsuccinic acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033147	Abnormal circulating short-chain fatty acid concentration	http://purl.obolibrary.org/obo/HP_0004359	Abnormal circulating fatty acid concentration		Any deviation from the normal concentration of short-chain fatty acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033148	Increased circulating isovaleric acid concentration	http://purl.obolibrary.org/obo/HP_0033147	Abnormal circulating short-chain fatty acid concentration		Increased concentration of isovaleric acid, a C5, branched-chain saturated fatty acid, in the blood concentration.
http://purl.obolibrary.org/obo/HP_0033149	Intrahepatic bile duct dilatation	http://purl.obolibrary.org/obo/HP_0011040	Abnormal intrahepatic bile duct morphology		Increased diameter (caliber) of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts).
http://purl.obolibrary.org/obo/HP_0033150	Anorectal abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		An abscess located at the junction of the anal canal and the rectum.
http://purl.obolibrary.org/obo/HP_0033152	Abnormal pharynx physiology	http://purl.obolibrary.org/obo/HP_0000600	Abnormality of the pharynx		A functional anomaly of the pharynx.
http://purl.obolibrary.org/obo/HP_0033153	Elevated circulating dodecenoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0430143	Elevated circulating C12 acylcarnitine concentration		An abnormally increased circulation of dodecenoylcarnitine, C12:1, in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033154	Elevated circulating deoxypyridinoline concentration	http://purl.obolibrary.org/obo/HP_0033386	Abnormal circulating collagen degradation product concentration		An increased concentration of lysyl-pyridinoline (deoxypyridinoline) cross-links in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033155	Elevated circulating L-alloisoleucine concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		Abnormally increased concentration of L-alloisoleucine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033156	Elevated urine L-alloisoleucine level	http://purl.obolibrary.org/obo/HP_0033097	Increased urine proteinogenic amino acid derivative level		Abnormally increased level of L-alloisoleucine in the urine.
http://purl.obolibrary.org/obo/HP_0033157	Elevated circulating 3-methylhistidine concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		Abnormal increase of the concentration of 3-methylhistidine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033158	Reduced respiratory ciliary beating frequency	http://purl.obolibrary.org/obo/HP_0012261	Abnormal respiratory motile cilium physiology		An abnormal reduction in the number of beats per unit time of the respiratory cilia.
http://purl.obolibrary.org/obo/HP_0033159	Reduced urinary inosine level	http://purl.obolibrary.org/obo/HP_0040421	Abnormal urinary inosine level		The amount of inosine in the urine, normalized for urine concentration, is below the lower limit of normal. Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
http://purl.obolibrary.org/obo/HP_0033160	Decreased urinary guanosine level	http://purl.obolibrary.org/obo/HP_0040423	Abnormal urinary guanosine level		The amount of guanosine in the urine, normalized for urine concentration, is below the lower limit of normal. Guanosine is a purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level	http://purl.obolibrary.org/obo/HP_0032572	Abnormal urinary nucleobase concentration		Any deviation from the normal amount of a purine compound in the urine. Purines are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring. Two of the four deoxyribonucleotides (deoxyadenosine and deoxyguanosine) and two of the four ribonucleotides (adenosine, or AMP, and guanosine, or GMP) are purines.
http://purl.obolibrary.org/obo/HP_0033163	Small intestinal bacterial overgrowth	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		An increased number and/or abnormal type of bacteria in the small bowel. Small intestinal bacterial overgrowth has been defined as the presence of greater than one hundred thousand bacteria (i.e. colony-forming units, CFU) per mL of proximal jejunal aspiration. The normal value is ten thousand or few CFU/ml.
http://purl.obolibrary.org/obo/HP_0033164	Focal active colitis	http://purl.obolibrary.org/obo/HP_0002583	Colitis		Focal active colitis (FAC) is characterized by focal crypt damage caused by neutrophils. FAC is characterized by an inflammatory infiltrate consisting of intraepithelial neutrophils and/or neutrophils invading the lumen of the criptae, with no other microscopic alteration of the colonic mucosa and, in particular, without the presence of signs of chronic inflammation.
http://purl.obolibrary.org/obo/HP_0033165	Necrotizing enterocolitis	http://purl.obolibrary.org/obo/HP_0004387	Enterocolitis		Inflammation of the intestine leading to bacterial invasion causing cellular damage and death which causes necrosis of the colon and intestine.
http://purl.obolibrary.org/obo/HP_0033166	Recurrent viral upper respiratory tract infections	http://purl.obolibrary.org/obo/HP_0004429	Recurrent viral infections		An increased susceptibility to viral upper respiratory tract infections as manifested by a history of recurrent viral upper respiratory tract infections (otitis, sinusitis, pharyngitis, tonsillitis).
http://purl.obolibrary.org/obo/HP_0033167	Neutrophilic urticarial dermatosis	http://purl.obolibrary.org/obo/HP_0001025	Urticaria		A neutrophilic interstitial, perivascular and/or perieccrine infiltrate with leukocytoclasia. Notably, leukocytoclastic vasculitis is not present.
http://purl.obolibrary.org/obo/HP_0033168	Reduced mevalonate kinase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Abnormally reduced activity of mevalonate kinase, which is a key enzyme in the mevalonate biosynthetic pathway that leads to the synthesis of both cholesterol and nonsterol isoprenoids.
http://purl.obolibrary.org/obo/HP_0033169	Reduced total lung capacity	http://purl.obolibrary.org/obo/HP_0030878	Abnormality on pulmonary function testing		Abnormally reduced volume of air in the lungs upon the maximum effort of inspiration.
http://purl.obolibrary.org/obo/HP_0033170	Abnormal skinfold thickness measurement	http://purl.obolibrary.org/obo/HP_0004323	Abnormality of body weight		Any deviation from the normal range of a skinfold thickness, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers.
http://purl.obolibrary.org/obo/HP_0033171	Abnormal triceps skinfold thickness	http://purl.obolibrary.org/obo/HP_0033170	Abnormal skinfold thickness measurement		Any deviation from the normal range of the thickness of the triceps skinfold, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers.
http://purl.obolibrary.org/obo/HP_0033172	Increased triceps skinfold thickness	http://purl.obolibrary.org/obo/HP_0033171	Abnormal triceps skinfold thickness		Increased thickness of the triceps skinfold, which is measured halfway down the back of the upper arm is increased.
http://purl.obolibrary.org/obo/HP_0033173	Milky appearance of bronchoalveolar lavage fluid	http://purl.obolibrary.org/obo/HP_0032973	Abnormal bronchoalveolar lavage fluid morphology		Return of lavage fluid with a milky appearance due to the accumulation of a mixture of pulmonary surfactant, which is a lipoprotein complex, in the alveolar space.
http://purl.obolibrary.org/obo/HP_0033174	Bloody bronchoalveolar lavage fluid	http://purl.obolibrary.org/obo/HP_0032973	Abnormal bronchoalveolar lavage fluid morphology		Return of lavage fluid characteristically has a bloody appearance in pulmonary alveolar hemorrhage. This is due to admixture of blood, which typically increases with each consecutive lavage portion. Microscopically erythrocytes can be seen. After 24 to 48 h macrophages contain phagocytosed erythrocytes, indicating previous bleeding.
http://purl.obolibrary.org/obo/HP_0033175	Elevated circulating 5-oxoproline concentration	http://purl.obolibrary.org/obo/HP_0033108	Abnormal circulating proteinogenic amino acid derivative concentration		Concentration of L-pyroglutamic acid in the blood is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033176	Submandibular lymph node enlargement	http://purl.obolibrary.org/obo/HP_0002716	Lymphadenopathy		Increased size of the lymph nodes that are located beneath the mandible (lower jaw).
http://purl.obolibrary.org/obo/HP_0033177	Elevated circulating suberic acid concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		An increased concentration of suberic acid in the blood circulation. Suberic acid is an alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.
http://purl.obolibrary.org/obo/HP_0033178	Increased circulating interleukin 8 concentration	http://purl.obolibrary.org/obo/HP_0011117	Abnormal circulating interleukin concentration		An increased concentration of interleukin-8 in the circulation.
http://purl.obolibrary.org/obo/HP_0033179	Elevated circulating aconitic acid concentration	http://purl.obolibrary.org/obo/HP_0004354	Abnormal circulating carboxylic acid concentration		Concentration of aconitic acid in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033180	Torsion of appendix of testis	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		The appendix testis or hydatid of Morgagni, is a vestigial remnant of the Müllerian duct located on the superior pole of the testicle between the testis and epididymis. Although this appendage has no vital function, it is present in 50% of males. Torsion of twisting of this vestigial remnant can be incredibly painful, but usually requires no medical intervention.
http://purl.obolibrary.org/obo/HP_0033181	Spinal epidural abscess	http://purl.obolibrary.org/obo/HP_0025615	Abscess		Spinal epidural abscess (SEA) is caused by a suppurative infection in the epidural space. The mass effect of the abscess can compress and reduce blood flow to the spinal cord, conus medullaris, or cauda equina.
http://purl.obolibrary.org/obo/HP_0033182	Increased circulating cathepsin D level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		An increase in concentration of cathepsin D in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033183	Bilobed right lung	http://purl.obolibrary.org/obo/HP_0002101	Abnormal lung lobation		A developmental defect of pulmonary lobation characterized by the presence of only two lobes of the right lung.
http://purl.obolibrary.org/obo/HP_0033185	Triggered by EBV infection	http://purl.obolibrary.org/obo/HP_0033198	Triggered by viral infection		Applies to a sign or symptom that is provoked or brought about by infection by the Epstein-Barr virus.
http://purl.obolibrary.org/obo/HP_0033186	Misalignment of the pulmonary veins	http://purl.obolibrary.org/obo/HP_0030968	Abnormal pulmonary vein morphology		The term is commonly used to describe a putative abnormal location of pulmonary vein branches adjacent to pulmonary arteries within the same adventitial sheath. However, evidence has been provided that the vessels in question are not pulmonary veins, however represent dilated bronchial veins.
http://purl.obolibrary.org/obo/HP_0033187	Hyperimidodipeptiduria	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		Elevated levels of proline-containing dipeptides in urine.
http://purl.obolibrary.org/obo/HP_0033188	Cystic acne	http://purl.obolibrary.org/obo/HP_0001061	Acne		A severe type of acne characterized by the formation of cysts enclosing a mixture of keratin and sebum.
http://purl.obolibrary.org/obo/HP_0033189	Radiculomegaly	http://purl.obolibrary.org/obo/HP_0040220	Abnormal size of the dental root		Tooth root length more than 2 SD above mean, or subjectively apparently increased tooth root length.
http://purl.obolibrary.org/obo/HP_0033190	Hypertrichotic hyperpigmented patch	http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin		A large nonpalpable spot of the skin over 1 cm in dimension with increased pigmentation and increased hair growth.
http://purl.obolibrary.org/obo/HP_0033191	Increased circulating selenium concentration	http://purl.obolibrary.org/obo/HP_0031903	Abnormal circulating selenium concentration		An increased concentration of selenium in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033192	Decreased circulating selenium concentration	http://purl.obolibrary.org/obo/HP_0031903	Abnormal circulating selenium concentration		An abnormally reduced concentration of selenium in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033193	Ballooning hepatocyte degeneration	http://purl.obolibrary.org/obo/HP_0034713	Abnormal hepatocyte morphology		Swelling of the hepatocyte, rounding of its contour, and alteration of the cytoplasm, which takes on a reticulated, rarefied, or flocculant quality. The cytoplasm of the ballooned hepatocytes often contains clumps of eosinophilic ropey material known as Mallory-Denk bodies (MDBs) or Mallory hyaline, which is composed of hyperphosphorylated misfolded intermediate filaments, ubiquitin, and ubiquitin-binding protein P62.
http://purl.obolibrary.org/obo/HP_0033194	Perioral erythema	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the mouth.
http://purl.obolibrary.org/obo/HP_0033195	Perianal erythema	http://purl.obolibrary.org/obo/HP_0010783	Erythema		Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the anus.
http://purl.obolibrary.org/obo/HP_0033196	Portal inflammation	http://purl.obolibrary.org/obo/HP_0004297	Abnormality of the biliary system		Infiltration of portal fields by inflammatory cells.
http://purl.obolibrary.org/obo/HP_0033197	Hepatic lobular inflammation	http://purl.obolibrary.org/obo/HP_0030146	Abnormal liver parenchyma morphology		Infiltration of inflammatory cells in lobules of the liver. A focus of lobular inflammation can be defined as two or more inflammatory cells (neutrophils, lymphocytes and other mononuclear cells, eosinophils and microgranulomas) within the lobule present within the sinusoids or surrounding injured hepatocytes (ballooned or apoptotic hepatocytes).
http://purl.obolibrary.org/obo/HP_0033198	Triggered by viral infection	http://purl.obolibrary.org/obo/HP_0033184	Triggered by infection		Applies to a sign or symptom that is provoked or brought about by infection by a virus.
http://purl.obolibrary.org/obo/HP_0033199	Increased circulating interleukin 10 concentration	http://purl.obolibrary.org/obo/HP_0034162	Abnormal circulating interleukin 10 concentration		An elevation of the concentration of interleukin 10 in the blood circulation.
http://purl.obolibrary.org/obo/HP_0033200	Triceps hyporeflexia	http://purl.obolibrary.org/obo/HP_0012391	Hyporeflexia of upper limbs		Reduced intensity of the triceps tendon reflex.
http://purl.obolibrary.org/obo/HP_0033201	Biceps hyporeflexia	http://purl.obolibrary.org/obo/HP_0012391	Hyporeflexia of upper limbs		Reduced intensity of the biceps tendon reflex.
http://purl.obolibrary.org/obo/HP_0033202	Brachioradialis hyporeflexia	http://purl.obolibrary.org/obo/HP_0012391	Hyporeflexia of upper limbs		Reduced intensity of the brachioradialis tendon reflex.
http://purl.obolibrary.org/obo/HP_0033203	Brachioradialis hyperreflexia	http://purl.obolibrary.org/obo/HP_0007350	Upper limb hyperreflexia		Increased intensity of the brachioradialis reflex.
http://purl.obolibrary.org/obo/HP_0033204	Triceps hyperreflexia	http://purl.obolibrary.org/obo/HP_0007350	Upper limb hyperreflexia		Increased intensity of the triceps reflex.
http://purl.obolibrary.org/obo/HP_0033205	Biceps hyperreflexia	http://purl.obolibrary.org/obo/HP_0007350	Upper limb hyperreflexia		Increased intensity of the biceps reflex.
http://purl.obolibrary.org/obo/HP_0033206	Hyperactive Achilles reflex	http://purl.obolibrary.org/obo/HP_0002395	Lower limb hyperreflexia		Increased intensity of the Achilles reflex.
http://purl.obolibrary.org/obo/HP_0033207	Increased CD21low B cell proportion	http://purl.obolibrary.org/obo/HP_0025539	Abnormal B cell subset distribution		Increased proportion relative to B-lymphocytes of a subset of B lymphocytes characterized by dim/low levels of CD21, i.e., CD21-/low, in flow cytometry, and additionally enriched in autoreactive clones as determined for instance by clonse showing rheumatoid factor (anti-IgG) reactivity and antibodies recognizing cytoplasmic and to a lesser extent nuclear structures.
http://purl.obolibrary.org/obo/HP_0033208	Alveolar capillary dysplasia	http://purl.obolibrary.org/obo/HP_4000060	Abnormal pulmonary alveolar system development		A developmental defect of the alveolar airspace during cananicular lung development characterized by a decreased number of pulmonary capillaries located away from the alveolar epithelium, thickened alveolar septae, media hypertrophy of small pulmonary arteries and muscularization of distal arterioles, and in some cases lymphangiectasis.
http://purl.obolibrary.org/obo/HP_0033209	Acinar dysplasia	http://purl.obolibrary.org/obo/HP_0006703	Aplasia/Hypoplasia of the lungs		Arrest of lung development in the pseudoglandular stage (weeks 8 to 16 of human gestation) resulting in small sized lungs, predominantly composed of bronchial and bronchiolar structures embedded in abundant loose mesenchyme that is poorly vascularized. Acinar structures are essentially absent, with no significant formation of saccules and no alveoli.
http://purl.obolibrary.org/obo/HP_0033210	Congenital alveolar dysplasia	http://purl.obolibrary.org/obo/HP_0006703	Aplasia/Hypoplasia of the lungs		Arrest of lung development in the cananicular stage (weeks 18 to 26 of human gestation) resulting in simplified acinar spaces, frequently with abundant intervening mesenchyme and no alveoli. In later arrest growth stages early saccular formations may be seen. May resemble the lobular maldevelopment often seen in alveolar capillary dysplasia/misaligment of the pulmonary veins without vein misalignment or marked hypertensive changes of the pulmonary arteries.
http://purl.obolibrary.org/obo/HP_0033211	Decreased total iron binding capacity	http://purl.obolibrary.org/obo/HP_0033212	Abnormal total iron binding capacity		A reduction in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity.
http://purl.obolibrary.org/obo/HP_0033212	Abnormal total iron binding capacity	http://purl.obolibrary.org/obo/HP_0011031	Abnormality of iron homeostasis		Any deviation from the normal total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added.
http://purl.obolibrary.org/obo/HP_0033213	Elevated urine suberic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of suberic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0033214	Recurrent viral pneumonia	http://purl.obolibrary.org/obo/HP_0006532	Recurrent pneumonia		Increased susceptibility to viral pneumonia, as manifested by recurrent episodes of viral pneumonias.
http://purl.obolibrary.org/obo/HP_0033401	Tissue ischemia	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		Ischemia is defined as a restriction of arterial blood supply to a tissue associated with insufficient oxygenation to support the metabolis requirements of the tissue. Depending on the involved tissues, clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis. Additional associated manifestations include hemodynamic parameters (reduced blood pressure distal to the site of restricted arterial supply) and angiographic evidence of arterial occclusion.
http://purl.obolibrary.org/obo/HP_0033578	Pre-capillary pulmonary hypertension	http://purl.obolibrary.org/obo/HP_0004890	Elevated pulmonary artery pressure		Pre-capillary pulmonary hypertension is a haemodynamic condition characterized by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary vascular resistance (PVR 3 Wood units or more) accompanied by normal pulmonary artery wedge pressure (PAWP not more than 15 mmHg).
http://purl.obolibrary.org/obo/HP_0033582	Pulmonary interstitial lymphocyte infiltration	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		Abnormal accumulation of lymphocytes in the interstitium of the lung.
http://purl.obolibrary.org/obo/CL_0011030	dermal microvascular endothelial cell	http://purl.obolibrary.org/obo/CL_2000010	dermis blood vessel endothelial cell		Any microvascular endothelial cell that is part of the dermis.
http://purl.obolibrary.org/obo/HP_0025667	Fetal neck anomaly	http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology		A structural anomaly in the fetal neck region. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.
http://purl.obolibrary.org/obo/HP_0025668	Abnormal neck morphology	http://purl.obolibrary.org/obo/HP_0000464	Abnormality of the neck		Any structural anomaly of the neck region.
http://purl.obolibrary.org/obo/HP_0034058	Abnormal fetal morphology	http://purl.obolibrary.org/obo/HP_0034057	Fetal anomaly		Any structural anomaly of the fetus.
http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology	http://purl.obolibrary.org/obo/HP_0034057	Fetal anomaly		Any functional anomaly of the fetus.
http://purl.obolibrary.org/obo/HP_0034521	Periorificial hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		Scaling and overgrowth of horny tissue of the skin surrounding body orifices (including peri-auricular, peri-oral, peri-anal areas.
http://purl.obolibrary.org/obo/HP_0034522	Eosinophilic lymph node infiltration	http://purl.obolibrary.org/obo/HP_0034582	Abnormal lymph node cell composition		Presence of an elevated number of eosinophils in a lymph node (usually as demonstrated by lymph node biopsy).
http://purl.obolibrary.org/obo/HP_0034523	Blood parasite	http://purl.obolibrary.org/obo/HP_0031863	Bloodstream infectious agent		Detection of a parasitic organism in the blood stream. Blood parasites include malaria plasmodia, microfilaria species, trypanosomes (the causative agents of African sleeping sickness and South American Changas disease) and the causative agents of schistosomiasis of the bladder and the intestine.
http://purl.obolibrary.org/obo/HP_0034524	Bloodstream trypomastigotes	http://purl.obolibrary.org/obo/HP_0034523	Blood parasite		Presence of trypomastigote parasites in the blood stream. This finding can be demonstrated by the identification of trypomastigote parasites on peripheral blood smear.
http://purl.obolibrary.org/obo/HP_0034525	Adamantinoma	http://purl.obolibrary.org/obo/HP_0010622	Neoplasm of the skeletal system		A primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.
http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Deviation from the normal activity of an enzyme in muscle tissue.
http://purl.obolibrary.org/obo/HP_0034527	Reduced muscle phosphoglycerate kinase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Reduced activity of phosphoglycerate kinase (PGK) in muscle tissue. PGK is a glycolytic enzyme that catalyzes one of the two ATP-producing reactions in the glycolytic pathway, through the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.
http://purl.obolibrary.org/obo/HP_0034528	Reduced fibroblast type III procollagen synthesis	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		Diminished production of type III procollagen by cultured skin fibroblasts.
http://purl.obolibrary.org/obo/HP_0034529	Reduced muscle myoadenylate deaminase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Diminished activity of the enzyme myoadenylate deaminase. Myoadenylate deaminase is the muscle isoform of adenosine monophosphate (AMP) deaminase and catalyzes the deamination of AMP to inosine monophosphate and ammonia.
http://purl.obolibrary.org/obo/HP_0034530	Bent long bone	http://purl.obolibrary.org/obo/HP_0011314	Abnormal long bone morphology		A developmental defect of a long bone, such as the femur or the humerus, characterized by a sharply curve deviation located in the diaphysis (shaft) of the bone.
http://purl.obolibrary.org/obo/HP_0034531	Tracheal rupture	http://purl.obolibrary.org/obo/HP_0002778	Abnormal tracheal morphology		A break or tear in the trachea.
http://purl.obolibrary.org/obo/HP_0034532	Increased myocardial glycogen content	http://purl.obolibrary.org/obo/HP_0001637	Abnormal myocardium morphology		Elevated amount of glycogen in the myocardium.
http://purl.obolibrary.org/obo/HP_0034533	Triggered by monoamine oxidase inhibitor	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to a monoamine oxidase inhibitor.
http://purl.obolibrary.org/obo/HP_0034534	Triggered by serotonin reuptake inhibitor	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to a serotonin reuptake inhibitor.
http://purl.obolibrary.org/obo/HP_0034535	Ameliorated by acetazolamide	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with acetazolamide.
http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by treatment with a medication. Terms in this subhierarchy are intended to be used for cases in which the fact that a manifestation of a disease responds to a specific treatment can be used in the differential diagnosis.
http://purl.obolibrary.org/obo/HP_0034537	Ameliorated by vitamin B12	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with vitamin B12.
http://purl.obolibrary.org/obo/HP_0034538	Ameliorated by thiamine	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with thiamine.
http://purl.obolibrary.org/obo/HP_0034539	Ameliorated by dantrolene	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with dantrolene.
http://purl.obolibrary.org/obo/HP_0034540	Ameliorated by biotin	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with biotin.
http://purl.obolibrary.org/obo/HP_0034541	Reduced bone-marrow megakaryocyte size	http://purl.obolibrary.org/obo/HP_0012143	Abnormal megakaryocyte morphology		Decreased in average size (diameter) of megakaryocytes in the bone marrow. Megakaryocyte diameter can be assessed as using automated cellular imaging systems.
http://purl.obolibrary.org/obo/HP_0034542	Hairshafts with longitudinal grooves	http://purl.obolibrary.org/obo/HP_0003328	Abnormal hairshaft morphology		Long narrow depressions running lengthwise in hairshafts. This feature can be appreciated by scanning electron microsopy.
http://purl.obolibrary.org/obo/HP_0034543	Mycobacterium bacteremia	http://purl.obolibrary.org/obo/HP_0031864	Bacteremia		Presence of viable mycobacteria in the blood.
http://purl.obolibrary.org/obo/HP_0034544	Decreased delta-aminolevulinate dehydratase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced activity of the enzyme delta-aminolevulinate dehydratase. The enzyme is active in erythrocytes.
http://purl.obolibrary.org/obo/HP_0034545	Elevated circulating pancreatic secretory trypsin inhibitor activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Increased activity of the enzyme pancreatic secretory trypsin inhibitor in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034546	Presence of uterus in 46,XY individual	http://purl.obolibrary.org/obo/HP_0000812	Abnormal internal genitalia		A developmental anomaly in which an individual with an X chromosome and a Y chromosome (usually 46,XY) has a uterus. The uterus and Fallopian tubes are derived from the Müllerian duct and thus this phenotype is generally also associated with the presence of Fallopian tubes.
http://purl.obolibrary.org/obo/HP_0034547	Intraluminal meconium calcification	http://purl.obolibrary.org/obo/HP_0034207	Abnormal fetal gastrointestinal system morphology		Deposition of calcium in meconium present in the internal cavity of the fetal bowel. This manifestation may be the result of any distal intestinal obstruction.
http://purl.obolibrary.org/obo/HP_0034548	Portal vein hypoplasia	http://purl.obolibrary.org/obo/HP_0031941	Abnormal portal venous system morphology		A developmental defect characterized by underdevelopment of the portal vein.
http://purl.obolibrary.org/obo/HP_0034549	Adrenal leiomyoma	http://purl.obolibrary.org/obo/HP_0100631	Neoplasm of the adrenal gland		Adrenal leiomyoma is a rare, benign solid tumor that develops from the smooth muscle of the adrenal vein and its tributaries
http://purl.obolibrary.org/obo/HP_0034550	Small intestinal lymphoplasmacytic infiltrate	http://purl.obolibrary.org/obo/HP_0002244	Abnormal small intestine morphology		Infiltration of the wall of the small intestine by lymphocytes and mature plasma cells.
http://purl.obolibrary.org/obo/HP_0034551	Triggered by neuroleptic medication	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to neuroleptic (also known as antipsychotic) medication.
http://purl.obolibrary.org/obo/HP_0034552	Abnormal peroxisomal morphology	http://purl.obolibrary.org/obo/HP_0025461	Abnormal cell morphology		Structural anomaly of peroxisomes, which are small, membrane-enclosed metabolic organelles with roles in the metabolism of complex lipids and reactive ionic species.
http://purl.obolibrary.org/obo/HP_0034553	Absence of peroxisomes	http://purl.obolibrary.org/obo/HP_0034552	Abnormal peroxisomal morphology		Lack of observable peroxisomes. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy.
http://purl.obolibrary.org/obo/HP_0034554	Paucity of peroxisomes	http://purl.obolibrary.org/obo/HP_0034552	Abnormal peroxisomal morphology		Reduced number of observable peroxisomes per cell. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy.
http://purl.obolibrary.org/obo/HP_0034555	Reduced sulfide:quinone oxidoreductase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Reduced activity of the enzyme sulfide:quinone oxidoreductase, which typically is measured in a biopsy specimen from liver or muscle.
http://purl.obolibrary.org/obo/HP_0034556	Deficit at segmental level	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		Refers to distribution of neurological deficits that corresponds to a deficit of a specific spinal segment and all segments below it.
http://purl.obolibrary.org/obo/HP_0034557	Rhabdoid tumor	http://purl.obolibrary.org/obo/HP_0011792	Neoplasm by histology		Rhabdoid tumors are rare aggressive malignancies in infants and young children with a poor prognosis. The most common anatomic localizations are the central nervous system, the kidneys, and other soft tissues.
http://purl.obolibrary.org/obo/HP_0034558	Rhabdoid tumor of the ovary	http://purl.obolibrary.org/obo/HP_0034557	Rhabdoid tumor		A highly aggressive, extremely rare neoplasm of the ovary that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers.
http://purl.obolibrary.org/obo/HP_0034559	Cardiac rhabdoid tumor	http://purl.obolibrary.org/obo/HP_0034557	Rhabdoid tumor		A rare and aggressive neoplasms developing mainly in the kidney but also in cerebral and extra-cerebral tissues and rarely in the heart. Histologically, rhabdoid renal and extrarenal tumors share common characteristics. The cells are polygonal, with eccentric, vesicular nuclei and prominent nucleoli, eosinophilic cytoplasmic inclusions. The tumors have an infiltrative growth pattern, necrosis, and high proliferative index. The immunohistochemistry tools of investigation facilitate differential diagnosis by showing loss of INI-1 expression, usually accompanied by germline mutations of the SMARCB1 gene. When INI-1 is still expressed in the affected tissues, a rhabdoid tumor with SMARCA4 mutations should be considered.
http://purl.obolibrary.org/obo/HP_0034560	Malignant rhabdoid tumor of the bladder	http://purl.obolibrary.org/obo/HP_0034557	Rhabdoid tumor		A rhabdoid tumor (a rare aggressive malignancies in infants and young children with a poor prognosis) originating in the urinary bladder.
http://purl.obolibrary.org/obo/HP_0034561	Malignant rhabdoid tumor of liver	http://purl.obolibrary.org/obo/HP_0034557	Rhabdoid tumor		A malginant rhabdoid tumor (MRT) originating in the liver. MRT are best characterized by the presence of round or polygonal cells with abundant eosinophilic cytoplasm, typical eosinophilic perinuclear inclusions, vesicular nuclei and prominent nucleoli. Immunohistochemical expression of vimentin and epithelial markers and lack of staining for S-100, myoglobin and desmin are commonly found, but are non-specific.
http://purl.obolibrary.org/obo/HP_0034562	Malignant rhabdoid tumor of muscle	http://purl.obolibrary.org/obo/HP_0034557	Rhabdoid tumor		A malginant rhabdoid tumor (MRT) originating in muscle tissue.
http://purl.obolibrary.org/obo/HP_0034563	Neck teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		A teratoma located in the neck.
http://purl.obolibrary.org/obo/HP_0034564	Kidney teratoma	http://purl.obolibrary.org/obo/HP_0009792	Teratoma		A teratoma located in a kidney.
http://purl.obolibrary.org/obo/HP_0034565	Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level	http://purl.obolibrary.org/obo/HP_0033161	Abnormal urinary purine level		Increased amount of 5-amino-4-imidazolecarboxamide(AICA)-riboside in the urine. AICA-riboside is the dephosphorylated counterpart of AICAR, an intermediate of de novo purine biosynthesis.
http://purl.obolibrary.org/obo/HP_0034566	Aplasia of posterior communicating artery	http://purl.obolibrary.org/obo/HP_0031772	Abnormal posterior circulating artery morphology		A developmental anomnaly characterized by the lack of development of the posterior communicating artery.
http://purl.obolibrary.org/obo/HP_0034567	Optic pit	http://purl.obolibrary.org/obo/HP_0000587	Abnormal optic nerve morphology		A developmental anomaly characterized by congenital excavation of the optic nerve head.
http://purl.obolibrary.org/obo/HP_0034568	Ameliorated by naloxone	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with naloxone, an opioid antagonist.
http://purl.obolibrary.org/obo/HP_0034569	Ameliorated by pyridoxal phosphate	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by ingestion of pyridoxal phosphate (activated vitamin B6).
http://purl.obolibrary.org/obo/HP_0034570	Thickened intrahepatic portal venules	http://purl.obolibrary.org/obo/HP_0031941	Abnormal portal venous system morphology		Increased width of the vascular wall of portal venules within the liver.
http://purl.obolibrary.org/obo/HP_0034571	Ovarian fibrosis	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		Excessive proliferation of fibroblasts and deposition of extracellular matrix within the ovary.
http://purl.obolibrary.org/obo/HP_0034572	Pigment incontinence	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		A process in which melanosomes (melanin granules) are deposited in the dermis. The dermal melanosomes are observed to be mainly in macrophages. This phenomenon of pigmentary incontinence usually follows an inflammatory process with the basic feature of basal cell damage, such as in lichen planus, lupus erythematosus, Riehl's melanosis, incontinentia pigmenti (Bloch-Sulzberger), and fixed drug eruption. Incontinence of pigment, or dropping off of epidermal melanin into the dermis, frequently produces a clinically recognizable and characteristic slate-gray pigmentation.
http://purl.obolibrary.org/obo/HP_0034574	Reduced epidermal keratin 10 protein expression	http://purl.obolibrary.org/obo/HP_0035004	Reduced epidermal keratin protein expression		Amount of keratin 10 in the epidermis below the lower limit of normal. The findiong is typically ascertained by immunofluorescent microscopy.
http://purl.obolibrary.org/obo/HP_0034576	Reduced epidermal bullous pemphigoid antigen 1 protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		Lower than normal amount of bullous pemphigoid antigen 1 (BP230) in the epidermis.
http://purl.obolibrary.org/obo/HP_0034581	Bloodstream Trypanosoma cruzi	http://purl.obolibrary.org/obo/HP_0034523	Blood parasite		Presence of Trypanosoma cruzi in the blood stream. Trypanosoma cruzii is the etiological agent of Chagas disease.
http://purl.obolibrary.org/obo/HP_0034582	Abnormal lymph node cell composition	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		A deviation from the normal distribution of cell types or their relative proportions in a lymph node.
http://purl.obolibrary.org/obo/HP_0034583	Lipid-laden lymph node macrophages	http://purl.obolibrary.org/obo/HP_0034582	Abnormal lymph node cell composition		Lymph node with increased numbers of macrophages heavily laden with lipids.
http://purl.obolibrary.org/obo/HP_0034584	Abnormal pancreatic acinus morphology	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		Structural anomal of pancreatic acinus.
http://purl.obolibrary.org/obo/HP_0034585	Cochlear nerve hypoplasia	http://purl.obolibrary.org/obo/HP_0011396	Abnormality of the cochlear nerve		A developmental defect characterized by underdevelopment of the cochlear nerve.
http://purl.obolibrary.org/obo/HP_0034586	Glutathionuria	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		Level of glutathione in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034587	Nevus psiloliparus	http://purl.obolibrary.org/obo/HP_0003764	Nevus		Nevus psiloliparus is a rare fatty tissue nevus that is a marker for encephalocraniocutaneous lipomatosis, a neurocutaneous syndrome with ocular and central nervous system anomalies. Clinically, nevus psiloliparus is often described as a congenital alopecia and appears as an irregularly shaped, circumscribed area of alopecia on the scalp. Histopathology demonstrates a near-complete absence of mature hair follicles with preservation of arrector pili muscles and mature adipocytes within the dermis.
http://purl.obolibrary.org/obo/HP_0034588	Crypt hyperplasia	http://purl.obolibrary.org/obo/HP_0025129	Abnormal small intestinal mucosa morphology		Crypt hyperplasia denotes elongation of the length of the crypts of Lieberkuhn, a process that initially precedes villous atrophy. Elongation may be caused by expansion of the lamina propria as a result of the proliferation of stromal cells, an influx of inflammatory cells and tissue remodeling.
http://purl.obolibrary.org/obo/HP_0034589	Increased circulating dehydroepiandrosterone-sulfate concentration	http://purl.obolibrary.org/obo/HP_0500022	Abnormal circulating dehydroepiandrosterone concentration		Concentration of dehydroepiandrosterone-sulfate in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034590	Abnormal circulating thyroxine-binding globulin concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		Any deviation from the normal concentration of thyroxine-binding globulin in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034591	Decreased circulating thyroxine-binding globulin concentration	http://purl.obolibrary.org/obo/HP_0034590	Abnormal circulating thyroxine-binding globulin concentration		The concentration of thyroxine-binding globulin in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034592	Elevated circulating beta-aminoisobutyric acid concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An increased concentration of beta-aminoisobutyric acid in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034593	Elevated circulating dihydrouracil concentration	http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration		An increased concentration of dihydrouracil in the blood circulation. Dihydrouracil is an intermediate in the catabolism of uracil that is also known as 5,6-dihydrouracil.
http://purl.obolibrary.org/obo/HP_0034594	Elevated circulating dihydrothymine concentration	http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration		An increased concentration of dihydrothymine in the blood circulation. Dihydrouracil is an intermediate in the catabolism of thymine.
http://purl.obolibrary.org/obo/HP_0034595	Elevated circulating N-carbamoyl-beta-alanine concentration	http://purl.obolibrary.org/obo/HP_0033109	Abnormal circulating non-proteinogenic amino acid concentration		An increased concentrationof N-carbamoyl-beta-alanine in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034596	Elevated ciculating 5-hydroxymethyluracil concentration	http://purl.obolibrary.org/obo/HP_0004353	Abnormal circulating pyrimidine concentration		An increased concentration of 5-hydroxymethyluracil in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034597	Decreased CSF creatinine concentration	http://purl.obolibrary.org/obo/HP_0025454	Abnormal CSF metabolite concentration		Concentration of creatinine in the cerebrrospinal fluid below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034598	Elevated urinary creatine level	http://purl.obolibrary.org/obo/HP_6000531	Abnormal urinary organic compound level		An increased amount of creatine in the urine.
http://purl.obolibrary.org/obo/HP_0034599	Decreased circulating biotin concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Concentration of biotin in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034600	Elevated circulating thrombopoietin concentration	http://purl.obolibrary.org/obo/HP_0003117	Abnormal circulating hormone concentration		Concentration of thrombopoietin in the blood circulation above the upper limit of normal. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney that stimulates the production and differentiation of megakaryocytes.
http://purl.obolibrary.org/obo/HP_0034601	Decreased circulating C1q concentration	http://purl.obolibrary.org/obo/HP_0004431	Reduced circulating complement concentration		Concentration or activity of the C1q protein in the blood circulation below the lower limit of normal. C1q is the first component of the classical pathway and is composed of the C1qA chain, C1qB chain, and C1qC chain, which are encoded by C1qA, C1qB, and C1qC genes.
http://purl.obolibrary.org/obo/HP_0034602	Decreased circulating apolipoprotein A-II concentration	http://purl.obolibrary.org/obo/HP_0033459	Decreased circulating apolipoprotein concentration		The concentration of apolipoprotein A-II in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034604	Elevated circulating DOPA concentration	http://purl.obolibrary.org/obo/HP_0010996	Abnormal circulating monocarboxylic acid concentration		Concentration of DOPA (3,4-dihydroxyphenylalanine) in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034605	Elevated CSF DOPA concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		Concentration of DOPA (3,4-dihydroxyphenylalanine) in the cerebrospinal fluid above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034606	Elevated circulating porphyrin concentration	http://purl.obolibrary.org/obo/HP_0010472	Abnormal circulating porphyrin concentration		The concentration of porphyrins in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034607	Decreased circulating 17-hydroxyprogesterone concentration	http://purl.obolibrary.org/obo/HP_0008233	Decreased circulating progesterone		Concentration of 17-hydroxyprogesterone in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034608	Decreased circulating transcobalamin-2 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of transcobalamin-2 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034609	Polychromasia	http://purl.obolibrary.org/obo/HP_0004312	Abnormal reticulocyte morphology		Increased variation in the color of the erythrocytes (red blood cells), including pale red, normal or dark colors, indicating a highly variable hemoglobin concentration. Typically this indicates the release of immature erythrocytes in states of anemia.
http://purl.obolibrary.org/obo/HP_0034610	Decreased circulating myo-inositol concentration	http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration		Concentration of myo-inositol in the blood circulation below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034611	Elevated circulating arabinitol concentration	http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration		Concentration of arabinitol in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034612	Elevated urine arabitol level	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		Amount of arabitol in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034613	Elevated urine erythritol level	http://purl.obolibrary.org/obo/HP_0031979	Abnormal urine carbohydrate level		Amount of erythritol in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034614	Elevated circulating erythritol concentration	http://purl.obolibrary.org/obo/HP_0020349	Abnormal circulating sugar alcohol concentration		Concentration of erythritol in the blood circulation above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034615	Decreased circulating matrix metalloproteinase 2 concentration	http://purl.obolibrary.org/obo/HP_0010876	Abnormal circulating protein concentration		The concentration of matrix metalloproteinase 2 in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034616	Abnormal circulating coenzyme concentration	http://purl.obolibrary.org/obo/HP_0430071	Abnormal circulating organic compound concentration		Concentration of a coenzyme (an organic molecule that binds to the active sites of an enzyme to promote the catalysis of a reaction) is above or below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034617	Elevated circulating S-adenosyl methionine concentration	http://purl.obolibrary.org/obo/HP_0034616	Abnormal circulating coenzyme concentration		Concentration of S-adenosyl methionine (SAM) in the blood circulation above the upper limit of normal. SAM is a cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.
http://purl.obolibrary.org/obo/HP_0034618	Abnormal circulating membrane cofactor protein concentration	http://purl.obolibrary.org/obo/HP_0032213	Increased urinary renal tubular epithelial cell count		Any deviation from the normal concentration of membrane cofactor protein in the blood circulation.
http://purl.obolibrary.org/obo/HP_0034619	Decreased circulating membrane cofactor protein concentration	http://purl.obolibrary.org/obo/HP_0034618	Abnormal circulating membrane cofactor protein concentration		The concentration of membrane cofactor protein in the blood circulation is below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034620	Elevated circulating membrane cofactor protein concentration	http://purl.obolibrary.org/obo/HP_0034618	Abnormal circulating membrane cofactor protein concentration		The concentration of membrane cofactor protein in the blood circulation is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034621	Hepatic xanthomatosis	http://purl.obolibrary.org/obo/HP_0410042	Abnormal liver morphology		Lipid deposits localized within the liver. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034622	Adrenal xanthomatosis	http://purl.obolibrary.org/obo/HP_0011732	Abnormal adrenal morphology		Lipid deposits localized within the adrenal gland. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034623	Splenic xanthomatosis	http://purl.obolibrary.org/obo/HP_0025408	Abnormal spleen morphology		Lipid deposits localized within the spleen. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034624	Spinal cord xanthomatosis	http://purl.obolibrary.org/obo/HP_0002143	Abnormal spinal cord morphology		Lipid deposits localized within the spinal cord. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034625	Brain xanthomatosis	http://purl.obolibrary.org/obo/HP_0012443	Abnormal brain morphology		Lipid deposits localized within the brain. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034626	Pulmonary xanthomatosis	http://purl.obolibrary.org/obo/HP_0002088	Abnormal lung morphology		Lipid deposits localized within the lung. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034627	Bone marrow xanthomatosis	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		Lipid deposits localized within the bone marrow. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034628	Lymph node xanthomatosis	http://purl.obolibrary.org/obo/HP_0002733	Abnormal lymph node morphology		Lipid deposits localized within one or more lymph nodes. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.
http://purl.obolibrary.org/obo/HP_0034629	Xanthoma of bone	http://purl.obolibrary.org/obo/HP_0011842	Abnormal skeletal morphology		Xanthoma of bone is an exceedingly rare benign primary bone tumor histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells.
http://purl.obolibrary.org/obo/HP_0034630	Ameliorated by folinic acid	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to a sign or symptom that is improved or made more bearable by treatment with folinic acid.
http://purl.obolibrary.org/obo/HP_0034631	Triggered by succinylcholine anesthetic	http://purl.obolibrary.org/obo/HP_4000101	Triggered by exposure to medication		Applies to a sign or symptom that is provoked or brought about by exposure to a succinylcholine anesthetic such as suxamethonium.
http://purl.obolibrary.org/obo/HP_0034632	Exogenous androgen exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with an exogenous androgen medication.
http://purl.obolibrary.org/obo/HP_0034633	Reduced muscle enolase activity	http://purl.obolibrary.org/obo/HP_0034526	Abnormal enzyme activity in muscle tissue		Diminished activity of the enzyme enolase in muscle tissue. The enzyme enolase catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. In adult human muscle, over 90% of enolase activity is accounted for by the beta-enolase subunit, the protein product of the ENO3 gene.
http://purl.obolibrary.org/obo/HP_0034634	Dopamine antagonist exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with a dopamine antagonist including metaclopramide, phenothiazine; haloperidol, chlorpromazine, promethazine, prochlorperazine, ziprasidone, and quetiapine.
http://purl.obolibrary.org/obo/HP_0034635	Muscle fiber granulofilamentous inclusion bodies	http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies		The presence of inclusion bodies within the cytoplasm of muscle cells that contain a mxiture of granules and filaments.
http://purl.obolibrary.org/obo/HP_0034636	Bone marrow myeloid vacuolization	http://purl.obolibrary.org/obo/HP_0012130	Abnormal erythroid lineage cell morphology		Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of myeloid precursors in the bone marrow.
http://purl.obolibrary.org/obo/HP_0034637	Pulmonary cylindroma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		A cylindroma located in the lung. Cylindromas are well-circumscribed, smooth, pale pink nodular tumors, often with arborizing vessels visible. The tumors are slow growing and vary in size from a few millimeters to over 5 mm.
http://purl.obolibrary.org/obo/HP_0034638	Colonic fibrinopurulent exudate	http://purl.obolibrary.org/obo/HP_0002250	Abnormal large intestine morphology		Fluid visible on the colonic surface containing fibrin, inflammatory cells, and cellular debris.
http://purl.obolibrary.org/obo/HP_0034639	Bloodstream microfilaria	http://purl.obolibrary.org/obo/HP_0034523	Blood parasite		Presence of filaria in the blood stream. Filariasis is a common cause of elephantiasis in Coastal Districts of India. The initial manifestations are repeated episodes of fever with chills and rigor, lymphadenopathy which gradually progress to elephantiasis. In India filarial infestation is commonly caused by W. bancrofti and Brugia malayi, the former responsible for almost 98 percent of all cases.
http://purl.obolibrary.org/obo/HP_0034640	Skin infectious agent	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		The presence of an infectious agent in the skin.
http://purl.obolibrary.org/obo/HP_0034641	Dermal microfilaria	http://purl.obolibrary.org/obo/HP_0034640	Skin infectious agent		Presence of filariae in the skin.
http://purl.obolibrary.org/obo/HP_0034642	Dermal papillary IgA deposition	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		Accumulation of immunoglobulin A (IgA) surrounding dermal papillae, which are specialized cells that support the hair follicle.
http://purl.obolibrary.org/obo/HP_0034643	Dermal immune complex deposition	http://purl.obolibrary.org/obo/HP_0011121	Abnormal skin morphology		Accumulation of antigen-bound antibody in the skin.
http://purl.obolibrary.org/obo/HP_0034644	Abnormal liver metabolite concentration	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		The concentration of a metabolite in the liver is above or below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034645	Hepatic polyglucosan accumulation	http://purl.obolibrary.org/obo/HP_0031137	Storage in hepatocytes		Intracellular accumulation of polyglucosan bodies-containing amylopectinlike polysaccharide-in the liver.
http://purl.obolibrary.org/obo/HP_0034646	Urinary bladder neurofibroma	http://purl.obolibrary.org/obo/HP_0009725	Bladder neoplasm		A neurofibroma (benign peripheral nerve sheath tumor) located in the urinary bladder.
http://purl.obolibrary.org/obo/HP_0034647	Synovial granuloma	http://purl.obolibrary.org/obo/HP_0005262	Abnormal synovial membrane morphology		An aggregation of macrophages (forming in response to chronic inflammation) localized in the lining of a joint (synovium).
http://purl.obolibrary.org/obo/HP_0034648	Elevated urine fumaric acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of fumaric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034649	Elevated urine N-acetylaspartic acid level	http://purl.obolibrary.org/obo/HP_0033098	Increased urinary non-proteinogenic amino acid level		The amount of N-acetylaspartate in the urine, when corrected for urine concentration, is above upper limit of normal. This feature can be measured using gas chromatography-mass spectrometry.
http://purl.obolibrary.org/obo/HP_0034650	Elevated urine suberylglycine level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		Level of suberylglycine in urine above upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034651	Elevated urine phenylpropionylglycine level	http://purl.obolibrary.org/obo/HP_0031980	Abnormal urine carboxylic acid level		Level of phenylpropionylglycine in urine above upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034652	Elevated urine octenedioic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of octenedioic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Level of a monocarboxylic acid in the urine above the upper limit of normal. A monocarboxylic acid is an oxoacid containing one carboxy group.
http://purl.obolibrary.org/obo/HP_0034654	Elevated urine octanoic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		Amount of octanoic acid in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034655	Elevated urine glutaconic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of glutaconic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034656	Elevated urine 3-hydroxyglutaric level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of 3-hydroxyglutaric acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034657	Elevated urine malonic acid level	http://purl.obolibrary.org/obo/HP_0003215	Dicarboxylic aciduria		The concentration of malonic acid in the urine, normalized for urine concentration, is above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034658	Elevated urine propionylglycine level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Amount of propionylglycine in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034659	Elevated urine tiglylglycine level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Amount of tiglylglycine in the urine above upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034660	Elevated urine 2-methylacetoacetic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		Amount of 2-methylacetoacetic acid in the urine above upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034661	Elevated urine 3-hydroxypropionic acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		Amount of 3-hydroxypropionic acid in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034662	Elevated urine 2-methylcitric acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Amount of 2-methylcitric acid in the urine above the upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034663	Elevated urine 4-hydroxyisovaleric acid level	http://purl.obolibrary.org/obo/HP_0034653	Monocarboxylic aciduria		Amount of 4-hydroxyisovaleric acid in urine above upper limit of normal.
http://purl.obolibrary.org/obo/HP_0034664	Elevated urine 2-hydroxy-3-methylvaleric acid level	http://purl.obolibrary.org/obo/HP_0040156	Elevated urinary carboxylic acid		Amount of 2-hydroxy-3-methylvaleric acid in the urine above the upper limit of normal. 2-Hydroxy-3-methylpentanoic acid or 2-hydroxy-3-methylvaleric acid (HMVA) is an organic acid generated by L-isoleucine metabolism.
http://purl.obolibrary.org/obo/HP_0034665	Shoulder contracture	http://purl.obolibrary.org/obo/HP_0100360	Upper-limb joint contracture		Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the shoulder joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.
http://purl.obolibrary.org/obo/HP_0034666	Shoulder extension contracture	http://purl.obolibrary.org/obo/HP_0034665	Shoulder contracture		Lack of the full expected passive range of flexion of the shoulder joint (Shoulder flexion puts the arms from a resting position at one's sides to straight above the head; thus, with shoulder extension contracture it is not possible to raise the arms above the head fully).
http://purl.obolibrary.org/obo/HP_0034667	Thumb extension contracture	http://purl.obolibrary.org/obo/HP_0009600	Thumb contracture		Movement in the sagittal plane that increases the angle of the thumb joint (straightens the joint); motion involving posterior bending of the vertebral column or returning to the upright position from a flexed position.
http://purl.obolibrary.org/obo/HP_0034668	Tongue myxoma	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		A myxoma (benign soft tissue neoplasm characterized by the presence of spindle and stellate cells, lobulated growth pattern, and myxoid stroma formation) localized in the tongue.
http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology	http://purl.obolibrary.org/obo/HP_0002815	Abnormality of the knee		A structural abnormality of the knee joint or surrounding structures.
http://purl.obolibrary.org/obo/HP_0034670	Abnormal knee physiology	http://purl.obolibrary.org/obo/HP_0002815	Abnormality of the knee		A functional anomaly of the knee joint.
http://purl.obolibrary.org/obo/HP_0034671	Knee contracture	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the knee joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.
http://purl.obolibrary.org/obo/HP_0034672	Knee extension contracture	http://purl.obolibrary.org/obo/HP_0034671	Knee contracture		A type of knee joint contracture in which the knee lacks full expected flexion, such that the upper and lower leg cannot be brought together.
http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology	http://purl.obolibrary.org/obo/HP_0003028	Abnormality of the ankle		A structural anomaly of the ankle.
http://purl.obolibrary.org/obo/HP_0034674	Abnormal ankle physiology	http://purl.obolibrary.org/obo/HP_0003028	Abnormality of the ankle		A functional anomaly of the ankle.
http://purl.obolibrary.org/obo/HP_0034675	Toe joint contracture	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a toe joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.
http://purl.obolibrary.org/obo/HP_0034676	Extension contracture of toe	http://purl.obolibrary.org/obo/HP_0034675	Toe joint contracture		A type of toe joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together.
http://purl.obolibrary.org/obo/HP_0034681	Finger joint contracture	http://purl.obolibrary.org/obo/HP_0009473	Joint contracture of the hand		Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a finger joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.
http://purl.obolibrary.org/obo/HP_0034682	Extension contracture of finger	http://purl.obolibrary.org/obo/HP_0034681	Finger joint contracture		A type of finger joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together.
http://purl.obolibrary.org/obo/HP_0034683	Reduced muscle telethonin level	http://purl.obolibrary.org/obo/HP_0030089	Abnormal muscle fiber protein expression		Amount of telethonin protein expression in muscle tissue below lower limit of normal. Telethonin is a 19-kDa sarcomeric protein, localized to the Z-disc of skeletal and cardiac muscles.
http://purl.obolibrary.org/obo/HP_0034684	Abnormal enzyme concentration or activity	http://purl.obolibrary.org/obo/HP_0001939	Abnormality of metabolism/homeostasis		Concentration or activity of an enzyme is above or below the limits of normal.
http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration	http://purl.obolibrary.org/obo/HP_6000231	Abnormal tissue enzyme concentration or activity		Concentration or activity of an enzyme is above or below the limits of normal in liver tissue.
http://purl.obolibrary.org/obo/HP_0034686	Reduced hepatic urocanase activity	http://purl.obolibrary.org/obo/HP_0034685	Abnormal liver enzyme activity or concentration		Activity of urocanase in the liver below the lower limit of normal.
http://purl.obolibrary.org/obo/HP_0034687	Impaired cerebroside sulfate hydrolysis	http://purl.obolibrary.org/obo/HP_0011017	Abnormal cellular physiology		Reduced hydrolysis (splitting of a bond and the addition of the hydrogen anion of water) of the sulfuric ester linkage in the molecule of cerebroside sulfate, possibly leading to accumuation of cerebroside sulfate.
http://purl.obolibrary.org/obo/HP_0034688	Reduced peroxisomal glutaryl-CoA oxidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Diminished enzyme activity of peroxisomal glutaryl-CoA oxidase, an enzyme that metabolizes glutaryl-CoA (a metabolite of L-lysine, L-hydroxy-lysine and L-tryptophan) by dehydrogenation to glutaconyl-CoA directly followed by decarboxylation of this to crotonyl-CoA.
http://purl.obolibrary.org/obo/HP_0034689	Reduced sterol 27-hydroxylase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Diminished activity of the enzyme sterol 27-hydroxylase, which participates in the degradation of cholesterol to bile acid. Sterol 27-hydroxylase catalyzes the first step in the normal oxidation of the steroid side chain, converting cholesterol, as well as different 7a-hydroxylated cholesterol metabolites, to 27-oxygenated steroids.
http://purl.obolibrary.org/obo/HP_0034690	Reduced short-chain acyl-CoA dehydrogenase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Diminished activity of the enzyme Short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid beta-oxidation that catalyzes the first step in mitochondrial beta-oxidation of fatty acids.
http://purl.obolibrary.org/obo/HP_0034691	Reduced 3-phosphoglycerate dehydrogenase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+.
http://purl.obolibrary.org/obo/HP_0034692	Elongated mitochondria	http://purl.obolibrary.org/obo/HP_0012087	Abnormal mitochondrial shape		Increase in length of mitochondria.
http://purl.obolibrary.org/obo/HP_4000162	Decreased Succinyl-CoA 3-ketoacid CoA transferase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Decreased activity of the enzyme succinyl-CoA 3-ketoacid CoA transferase.
http://purl.obolibrary.org/obo/HP_4000163	Reduced phytanic acid oxidase activity in cultured fibroblasts	http://purl.obolibrary.org/obo/HP_4000195	Abnormal enzyme activity in cultured fibroblasts		Activity of the enzyme phytanoyl-CoA hydroxylase (PhyH; EC 1.14.11.18) below the lower limit of normal in cultured fibroblasts. PhyH plays a role in the catabolism of phytanic acid, a branched-chain fatty acid that is a normal constituent of the human diet.
http://purl.obolibrary.org/obo/HP_4000164	Reduced bifunctional protein activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		Diminished activity of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4), also known as D-bifunctional protein (DBP), a peroxisomal enzyme that catalyzes multiple steps of beta-oxidation of very long chain fatty acids.
http://purl.obolibrary.org/obo/HP_4000165	Decreased circulating plasmalogen concentration	http://purl.obolibrary.org/obo/HP_0040176	Abnormal circulating phospholipid concentration		Reduced plasmalogen concentration in the blood circulation.
http://purl.obolibrary.org/obo/HP_4000166	Post-vaccination varicella zoster virus infection	http://purl.obolibrary.org/obo/HP_0020085	Infection following live vaccination		Infection with live, attenuated varicella-zoster virus following vaccination. This is an extremely rare event that may indicate immunocompromise.
http://purl.obolibrary.org/obo/HP_4000167	Recent steroid exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with corticosteroid medications in recent weeks.
http://purl.obolibrary.org/obo/HP_4000168	Shark teeth	http://purl.obolibrary.org/obo/HP_0006292	Abnormality of dental eruption		Eruption of permanent teeth behind deciduous (baby) teeth before they have fallen out, resulting in a double row of teeth. This phenomen is typically observed between the ages of 5 to 7 years.
http://purl.obolibrary.org/obo/HP_4000169	Pontine T2 hypointensity	http://purl.obolibrary.org/obo/HP_0007361	Abnormal pons morphology		A darker than expected T2 signal on magnetic resonance imaging (MRI) of the pons.
http://purl.obolibrary.org/obo/HP_4000170	Anti-platelet antigen antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against antigens present on the surface of thrombocytes such as the glycoproteins GPIIb/IIIa, GPIb/IX, and GPIa/IIa.
http://purl.obolibrary.org/obo/HP_4000171	Anti-voltage-gated potassium channel antibody positivity	http://purl.obolibrary.org/obo/HP_0030057	Autoimmune antibody positivity		The presence of autoantibodies (immunoglobulins) in the serum that react against a voltage-gated potassium channel.
http://purl.obolibrary.org/obo/HP_4000172	Vegan diet	http://purl.obolibrary.org/obo/HP_4000123	Nutrition history		A history of following a vegan diet characterized by avoidance of food sourced from animals including meat, fish, and dairy products.
http://purl.obolibrary.org/obo/HP_4000173	History of previous pregnancy with hydrops fetalis	http://purl.obolibrary.org/obo/HP_0032467	Past obstetric history		One or more previous pregnancies in which the fetus developed hydrops fetalis.
http://purl.obolibrary.org/obo/HP_4000174	Ameliorated by potassium supplements	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by ingesting a potassium supplement.
http://purl.obolibrary.org/obo/HP_4000175	Ameliorated by niacin	http://purl.obolibrary.org/obo/HP_0025254	Ameliorated by		Applies to a sign or symptom that is improved or made more bearable by ingesting niacin (vitamin B3).
http://purl.obolibrary.org/obo/HP_4000176	Aggravated by exposure to medication	http://purl.obolibrary.org/obo/HP_0025285	Aggravated by		Applied to a sign or symptom that is worsened by treatment with a medication.
http://purl.obolibrary.org/obo/HP_4000177	Bleeding ameliorated by vitamin K	http://purl.obolibrary.org/obo/HP_0034536	Ameliorated by exposure to medication		Applies to bleeding that is significantly reduced by treatment with vitamin K.
http://purl.obolibrary.org/obo/HP_4000178	Anti-retroviral therapy exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with an antiretroviral agent.
http://purl.obolibrary.org/obo/HP_4000179	Potassium-wasting diuretic exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with a potassium-wasting diuretic such as thiazide (chlorothiazide, chlorthalidone, hydrochlorothiazide, indapamide, metolazone) and loop (bumetanide, ethacrynic acid, furosemide, torsemide) diuretics.
http://purl.obolibrary.org/obo/HP_4000180	Tricyclic antidepressant exposure	http://purl.obolibrary.org/obo/HP_4000112	Medication history		History of having been treated with a tricyclic antidepressant medication.
http://purl.obolibrary.org/obo/HP_4000181	Excessive dental attrition	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		A higher than expected amount of attrition of teeth, as menifested by loss of tooth characteristics including rounding or sharpening of incisal edges, loss of cusps, and fracturing of teeth, to an extent that is deemed more than would be expected at a given age.
http://purl.obolibrary.org/obo/HP_4000182	Positionally dependent pain	http://purl.obolibrary.org/obo/HP_0025280	Pain characteristic		Pain improves or worsens with changes in body position.
http://purl.obolibrary.org/obo/HP_5200001	Selective mutism	http://purl.obolibrary.org/obo/HP_0002300	Mutism		Voluntary failure to use spoken language (at whatever level attained) in selective social contexts over a period of time.
http://purl.obolibrary.org/obo/HP_5200002	Limited repertoire of facial expression	http://purl.obolibrary.org/obo/HP_4000087	Abnormal communicative facial expressions		An abnormally limited range of facial expressions demonstrated by a lack of nuance of facial expression to match specific social situations or an inability to demonstrate a normal range of emotions with one's face.
http://purl.obolibrary.org/obo/HP_5200003	Excessive interest in others	http://purl.obolibrary.org/obo/HP_5200020	Abnormal interest in others		A strong desire to interact and engage with others that is perceived to be inappropriate or excessive in the context of cultural norms.
http://purl.obolibrary.org/obo/HP_5200005	Abnormal pitch	http://purl.obolibrary.org/obo/HP_5200010	Abnormal Intonation		Persistently abnormally high or low-pitched vocalization or speech than is considered the norm for the context of social situation or significantly different from baseline of the individual.
http://purl.obolibrary.org/obo/HP_5200006	Disjointed sentences	http://purl.obolibrary.org/obo/HP_0025782	Abnormal syntax		Persistent abnormalities in the sentence structure in speech, phrases may not be logically connected to each other, gives the impression of rambling. This may be a characteristic feature of the individual or may be a change from the norm of the affected individual.
http://purl.obolibrary.org/obo/HP_5200007	Neologism	http://purl.obolibrary.org/obo/HP_0025773	Abnormal semantics		Consistent use of an invented word that is unique to an individual.
http://purl.obolibrary.org/obo/HP_5200008	Overly formal/pedantic language	http://purl.obolibrary.org/obo/HP_0025773	Abnormal semantics		Use of language that is overly formal, precise, detailed, or pedantic for the social context.
http://purl.obolibrary.org/obo/HP_5200009	Midline hand movements	http://purl.obolibrary.org/obo/HP_5200018	Stereotypic upper-extremity movements		Hand stereotypies within the medial plane of the body.
http://purl.obolibrary.org/obo/HP_5200010	Abnormal Intonation	http://purl.obolibrary.org/obo/HP_0031434	Abnormal prosody		Abnormal rise and fall of the voice in speech and vocalization for the context and cultural situation.
http://purl.obolibrary.org/obo/HP_5200011	Abnormal speech rate	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		Speech that is abnormally fast or slow as compared to the perceived cultural norm.
http://purl.obolibrary.org/obo/HP_5200012	Abnormal speech rhythm	http://purl.obolibrary.org/obo/HP_0031434	Abnormal prosody		Speech with persistent abnormal rhythm or pattern for the context and cultural situation. This may occur constantly throughout conversations with the person or may occur in periodic bursts lasting several minutes to hours.
http://purl.obolibrary.org/obo/HP_5200013	Ambiguous facial expression	http://purl.obolibrary.org/obo/HP_4000089	Abnormal quality of facial expression		Spontaneous production of communicative facial expressions that have poor quality or are perceived as odd or mechanical. This may include inaccurate mimicry of typical facial expressions. These expressions may be difficult to interpret for someone who is not familiar with the individual making the expression.
http://purl.obolibrary.org/obo/HP_5200014	Exaggerated facial expression	http://purl.obolibrary.org/obo/HP_4000089	Abnormal quality of facial expression		A tendency to make facial expressions that are exaggerated and a failure to make subtle facial expressions in a social context when a subtle expression is more appropriate.
http://purl.obolibrary.org/obo/HP_5200015	Muted facial expression	http://purl.obolibrary.org/obo/HP_4000089	Abnormal quality of facial expression		A tendency to produce facial expressions with decreased intensity or expressivity which appear muted or flat.
http://purl.obolibrary.org/obo/HP_5200016	Abnormal peer relationships	http://purl.obolibrary.org/obo/HP_5200024	Abnormal relationship		The state of having abnormal relationships with others. This does not describe specific aspects of one's social aptitudes but rather a state which may come about from these aptitudes, such as lacking peer relationships or lacking close friends.
http://purl.obolibrary.org/obo/HP_5200017	Stereotypic movements of face and head	http://purl.obolibrary.org/obo/HP_0000733	Motor stereotypy		Abnormal movements of face and head.
http://purl.obolibrary.org/obo/HP_5200018	Stereotypic upper-extremity movements	http://purl.obolibrary.org/obo/HP_0000733	Motor stereotypy		Abnormal movements of the upper extremities.
http://purl.obolibrary.org/obo/HP_5200019	Stereotypic whole-body movements	http://purl.obolibrary.org/obo/HP_0000733	Motor stereotypy		Abnormal movements of the whole body.
http://purl.obolibrary.org/obo/HP_5200020	Abnormal interest in others	http://purl.obolibrary.org/obo/HP_0025732	Abnormal social development		A deviation from typical perceived social engagement with other individuals given the social context. This may manifest as either an excessive interest (e.g., persistent preoccupation with another person, excessive attempts to engage) or an abnormal lack of interest (e.g., minimal or absent social curiosity) in others.
http://purl.obolibrary.org/obo/HP_5200021	Reduced social insight	http://purl.obolibrary.org/obo/HP_5200401	Abnormal judgment		A lack of awareness of social rules in multiple social settings, which are simple or intuitive to others in the same social setting.
http://purl.obolibrary.org/obo/HP_5200022	Reduced awareness of convention	http://purl.obolibrary.org/obo/HP_5200021	Reduced social insight		Reduced awareness of expected conventions, which are normal and expected for particular social settings or interactions.
http://purl.obolibrary.org/obo/HP_5200024	Abnormal relationship	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		The state of having abnormal relationships with others. This does not describe specific aspects of one's social aptitudes but rather a state which may come about from these aptitudes, such as lacking peer relationships, lacking close friends, or having a relational network that is abnormal given one's cultural context.
http://purl.obolibrary.org/obo/HP_5200026	Impaired social imitation	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		Reduced use of imitation of tasks or movements of others in play or learning.
http://purl.obolibrary.org/obo/HP_5200027	Infrequent social initiations	http://purl.obolibrary.org/obo/HP_5200020	Abnormal interest in others		Social initiation refers to the ability to begin interactions with other people. This term refers to a reduction in the frequency with which an individual attempts to begin interactions. The term should only be used for individuals who are assessed to have sufficient intellectual and language skills to interact with others.
http://purl.obolibrary.org/obo/HP_5200028	Reduced responsiveness to social cues	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		A tendency to display responces to social cues that are interpreted (e.g., by family members, peers, or caregivers) as diminished compared to what would be expected based on the developmental stage and cultural context of an individual.
http://purl.obolibrary.org/obo/HP_5200029	Social disinhibition	http://purl.obolibrary.org/obo/HP_5200123	Abnormal response to social norms		A tendency to violate social norms because of a failure to resist temptations or urges in social settings.
http://purl.obolibrary.org/obo/HP_5200030	Diminished integration of verbal and non-verbal communicative behavior	http://purl.obolibrary.org/obo/HP_0034434	Abnormal communication		A communicative abnormality where one's nonverbal and verbal communication are poorly integrated. This may occur when verbal and nonverbal communication are intact alone but are abnormal when used together, or an abnormality in the use of typically integrated communication such as the use of beat gestures during speech.
http://purl.obolibrary.org/obo/HP_5200035	Reduced cooperative imaginative play	http://purl.obolibrary.org/obo/HP_5200136	Reduced social reciprocity		Failure of a child to engage with peers games that involve creating imaginary scenarios or narratives, for instance, in which children pretend to be characters or act out adventurous scenarios.
http://purl.obolibrary.org/obo/HP_5200037	Lack of expressed empathy	http://purl.obolibrary.org/obo/HP_0012760	Reduced social responsiveness		The observation that an affected person tends not to provide situationally appropriate responses to other people in times when these people are in emotional need. For instance, failure to provide comfort to a person who is sad or crying.
http://purl.obolibrary.org/obo/HP_5200038	Bradylalia	http://purl.obolibrary.org/obo/HP_5200011	Abnormal speech rate		Speech that is abnormally slow as compared to the perceived cultural norm.
http://purl.obolibrary.org/obo/HP_5200039	Excessively loud speech	http://purl.obolibrary.org/obo/HP_5200043	Abnormal speech volume		Speech which is persistently abnormally and noticeably loud or high volume for the social and cultural context and is not due to a structural or muscular abnormality. Those around the person often consider them to be shouting.
http://purl.obolibrary.org/obo/HP_5200040	Excessively quiet speech	http://purl.obolibrary.org/obo/HP_5200043	Abnormal speech volume		Speech which is persistently abnormally quiet, or of low in volume for the social and cultural context. This includes persistent and inappropriate whispering. It is not due to a medical or surgical condition that results in hoarseness, nor structural or muscular abnormality that results in low speech volume.
http://purl.obolibrary.org/obo/HP_5200043	Abnormal speech volume	http://purl.obolibrary.org/obo/HP_0002167	Abnormal speech pattern		Speech that is abnormally loud or quiet for the social and cultural context in which it is spoken. It is clinically noted by others, including family, friends, or clinical providers.
http://purl.obolibrary.org/obo/HP_5200044	Reduced attention regulation	http://purl.obolibrary.org/obo/HP_0100543	Cognitive impairment		An abnormality in one's ability to control their attention towards a specific subject or task can include difficulties in changing or maintaining attention.
http://purl.obolibrary.org/obo/HP_5200045	Reduced impulse control	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		Reduced ability to control, or a failure to resist a temptation, urge, or impulse.
http://purl.obolibrary.org/obo/HP_5200046	Sensory behavioral abnormality	http://purl.obolibrary.org/obo/HP_0000708	Atypical behavior		Abnormal sensory behavior, including avoiding or seeking sensory input or difficulty modulating sensory stimuli.
http://purl.obolibrary.org/obo/HP_5200047	Idiosyncratic gesture	http://purl.obolibrary.org/obo/HP_0034481	Atypical gestures		When one uses gestures that are unique to them and have no apparent meaning to others.
http://purl.obolibrary.org/obo/HP_5200049	Atypical sorting	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		Atypical focus on arranging, balancing, or positioning objects; may be atypical in focus or intensity.
http://purl.obolibrary.org/obo/HP_5200050	Excessive checking	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		Checking behavior that is excessive for the situational context.
http://purl.obolibrary.org/obo/HP_5200051	Excessive hand washing	http://purl.obolibrary.org/obo/HP_0000722	Compulsive behaviors		Hand washing behavior that is excessive for the situational context.
http://purl.obolibrary.org/obo/HP_5200052	Resistance to trivial environmental changes	http://purl.obolibrary.org/obo/HP_5200130	Insistence on sameness		Distress in response to minor changes in one's environmental expectations.
http://purl.obolibrary.org/obo/HP_5200055	Reduced co-speech gestures	http://purl.obolibrary.org/obo/HP_5200030	Diminished integration of verbal and non-verbal communicative behavior		Reduced use of speech-integrated gestures such as the use of beat gestures.
http://purl.obolibrary.org/obo/HP_5200056	Limited head nodding or shaking	http://purl.obolibrary.org/obo/HP_4000081	Reduced production of gestures		Absence or reduction in the use of head nodding to indicate agreement or head shaking to indicate disagreement.
http://purl.obolibrary.org/obo/HP_5200057	Limited pointing	http://purl.obolibrary.org/obo/HP_4000081	Reduced production of gestures		Absence or reduction in the use of pointing to request or direct another's attention.
http://purl.obolibrary.org/obo/HP_5200058	Sensory hypersensitivity	http://purl.obolibrary.org/obo/HP_5200046	Sensory behavioral abnormality		A decreased tolerance to sensory stimuli that triggers emotional and/or physical distress.
http://purl.obolibrary.org/obo/HP_5200060	Auditory hypersensitivity	http://purl.obolibrary.org/obo/HP_5200058	Sensory hypersensitivity		Hyperresponsive to sound that is abnormal in intensity and/or frequency.
http://purl.obolibrary.org/obo/HP_5200065	Tactile sensory seeking	http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking		Pursuit of a specific texture that is abnormal in intensity and/or frequency.
http://purl.obolibrary.org/obo/CL_0020011	hair follicle associated fibroblast	http://purl.obolibrary.org/obo/CL_0002620	skin fibroblast		A specialized dermal fibroblast within the hair follicle mesenchymal compartment that participates in epithelial-mesenchymal signaling to regulate hair morphogenesis, cycling, and homeostasis through production of inductive signals and extracellular matrix maintenance.
http://purl.obolibrary.org/obo/CL_4072103	hair follicle dermal stem cell	http://purl.obolibrary.org/obo/CL_0002559	hair follicle cell		A bipotent mesenchymal stem cell that resides in the dermal sheath, specifically within the dermal sheath cup at the base of the hair follicle, characterized by its capacity for self-renewal and differentiation into both dermal sheath and dermal papilla cells throughout hair cycling. In humans, this cell is marked by enriched expression of gremlin-2 (GREM2) and dipeptidase-1 (DPEP1), and acts as a progenitor reservoir sustaining and regenerating the follicle's mesenchymal compartments.
http://purl.obolibrary.org/obo/CL_0020029	cuboidal epithelial cell	http://purl.obolibrary.org/obo/CL_0000075	columnar/cuboidal epithelial cell		An epithelial cell that has a cuboidal morphology.
http://purl.obolibrary.org/obo/CL_0020030	CD4-positive exhausted alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000624	CD4-positive, alpha-beta T cell		A CD4-positive alpha-beta T cell that displays impaired function and altered differentiation as a result of chronic antigenic stimulation (e.g., chronic infection, tumors, or persistent inflammation). This state is characterised by sustained expression of PD-1 as a shared feature. Additional exhaustion-associated molecules, including the transcription factor TOX, and context- or stage-dependent changes in markers such as LAG-3, TIM-3, CD39, and T-bet, may also be observed; however, the expression levels of these molecules vary depending on exhaustion stage and tissue environment.
http://purl.obolibrary.org/obo/CL_0020031	CD8-positive exhausted alpha-beta T cell	http://purl.obolibrary.org/obo/CL_0000625	CD8-positive, alpha-beta T cell		A CD8-positive alpha-beta T cell that displays impaired function and altered differentiation as a result of chronic antigenic stimulation (e.g., chronic infection, tumours, or persistent inflammation). This state is characterised by sustained expression of PD-1 as a shared feature. Additional exhaustion-associated molecules, including expression of the transcription factor TOX and reduced T-bet, and context- or stage-dependent changes in markers such as LAG-3, TIM-3, CD39, and EOMES, may also be observed; however, the expression levels of these molecules vary depending on exhaustion stage and disease context.
http://purl.obolibrary.org/obo/HP_0100299	Muscle fiber inclusion bodies	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		
http://purl.obolibrary.org/obo/CHEBI_27216	urate(2-)	http://purl.obolibrary.org/obo/CHEBI_46818	urate anion		
http://purl.obolibrary.org/obo/CHEBI_35875	imidazopyrimidine	http://purl.obolibrary.org/obo/CHEBI_33833	heteroarene		
http://purl.obolibrary.org/obo/CHEBI_36887	18-oxo steroid	http://purl.obolibrary.org/obo/CHEBI_35789	oxo steroid		
http://purl.obolibrary.org/obo/CHEBI_33408	pnictogen oxoacid	http://purl.obolibrary.org/obo/CHEBI_33302	pnictogen molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33484	chalcogen oxoacid	http://purl.obolibrary.org/obo/CHEBI_33304	chalcogen molecular entity		
http://purl.obolibrary.org/obo/CHEBI_35605	carbon oxoacid	http://purl.obolibrary.org/obo/CHEBI_36963	organooxygen compound		
http://purl.obolibrary.org/obo/CHEBI_36029	butenoate	http://purl.obolibrary.org/obo/CHEBI_58951	short-chain fatty acid anion		
http://purl.obolibrary.org/obo/CHEBI_51447	organic univalent group	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		
http://purl.obolibrary.org/obo/CHEBI_51446	organic divalent group	http://purl.obolibrary.org/obo/CHEBI_33247	organic group		
http://purl.obolibrary.org/obo/CHEBI_22495	aminobenzoic acid	http://purl.obolibrary.org/obo/CHEBI_22723	benzoic acids		
http://purl.obolibrary.org/obo/CHEBI_36299	tricarboxylic acid monoanion	http://purl.obolibrary.org/obo/CHEBI_35753	tricarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_36853	hydroxy seco-steroid	http://purl.obolibrary.org/obo/CHEBI_35350	hydroxy steroid		
http://purl.obolibrary.org/obo/CHEBI_46723	phosphate mineral	http://purl.obolibrary.org/obo/CHEBI_46662	mineral		
http://purl.obolibrary.org/obo/CHEBI_233443	N-acetyl-L-alpha-amino acid anion	http://purl.obolibrary.org/obo/CHEBI_48927	N-acyl-L-alpha-amino acid		
http://purl.obolibrary.org/obo/CHEBI_33760	hexonate	http://purl.obolibrary.org/obo/CHEBI_22299	aldonate		
http://purl.obolibrary.org/obo/CHEBI_30353	isopropyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_36830	monoanion	http://purl.obolibrary.org/obo/CHEBI_22563	anion		
http://purl.obolibrary.org/obo/CHEBI_184023	Argininosuccinic acid	http://purl.obolibrary.org/obo/CHEBI_22661	aspartic acid derivative		
http://purl.obolibrary.org/obo/CHEBI_33242	inorganic hydride	http://purl.obolibrary.org/obo/CHEBI_33692	hydrides		
http://purl.obolibrary.org/obo/CHEBI_33262	elemental oxygen	http://purl.obolibrary.org/obo/CHEBI_33259	elemental molecular entity		
http://purl.obolibrary.org/obo/CHEBI_27365	zinc ion	http://purl.obolibrary.org/obo/CHEBI_37253	elemental zinc		
http://purl.obolibrary.org/obo/CHEBI_33973	elemental magnesium	http://purl.obolibrary.org/obo/CHEBI_25108	magnesium molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33513	alkaline earth cation	http://purl.obolibrary.org/obo/CHEBI_33299	alkaline earth molecular entity		
http://purl.obolibrary.org/obo/CHEBI_26833	sulfur atom	http://purl.obolibrary.org/obo/CHEBI_33303	chalcogen		
http://purl.obolibrary.org/obo/CHEBI_32656	D-asparaginate	http://purl.obolibrary.org/obo/CHEBI_32660	asparaginate		
http://purl.obolibrary.org/obo/CHEBI_32657	D-asparaginium	http://purl.obolibrary.org/obo/CHEBI_32661	asparaginium		
http://purl.obolibrary.org/obo/CHEBI_33433	monoatomic halogen	http://purl.obolibrary.org/obo/CHEBI_33238	monoatomic entity		
http://purl.obolibrary.org/obo/CHEBI_33861	transition element coordination entity	http://purl.obolibrary.org/obo/CHEBI_33497	transition element molecular entity		
http://purl.obolibrary.org/obo/CHEBI_35507	natural product fundamental parent	http://purl.obolibrary.org/obo/CHEBI_33245	organic fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_35552	heterocyclic organic fundamental parent	http://purl.obolibrary.org/obo/CHEBI_33245	organic fundamental parent		
http://purl.obolibrary.org/obo/CHEBI_35573	organic mancude parent	http://purl.obolibrary.org/obo/CHEBI_35568	mancude ring		
http://purl.obolibrary.org/obo/CHEBI_33434	elemental halogen	http://purl.obolibrary.org/obo/CHEBI_33259	elemental molecular entity		
http://purl.obolibrary.org/obo/CHEBI_33459	pnictogen oxoanion	http://purl.obolibrary.org/obo/CHEBI_35406	oxoanion		
http://purl.obolibrary.org/obo/CHEBI_35881	pnictogen hydride	http://purl.obolibrary.org/obo/CHEBI_33242	inorganic hydride		
http://purl.obolibrary.org/obo/CHEBI_33485	chalcogen oxoanion	http://purl.obolibrary.org/obo/CHEBI_35406	oxoanion		
http://purl.obolibrary.org/obo/CHEBI_27363	zinc atom	http://purl.obolibrary.org/obo/CHEBI_33340	zinc group element atom		
http://purl.obolibrary.org/obo/CHEBI_33561	d-block element atom	http://purl.obolibrary.org/obo/CHEBI_27081	transition element atom		
http://purl.obolibrary.org/obo/CHEBI_33663	cyclic hydrocarbon	http://purl.obolibrary.org/obo/CHEBI_24632	hydrocarbon		
http://purl.obolibrary.org/obo/CHEBI_27364	zinc molecular entity	http://purl.obolibrary.org/obo/CHEBI_33673	zinc group molecular entity		
http://purl.obolibrary.org/obo/CHEBI_24148	galactonate	http://purl.obolibrary.org/obo/CHEBI_33778	galactonates		
http://purl.obolibrary.org/obo/CHEBI_51958	organic polycyclic compound	http://purl.obolibrary.org/obo/CHEBI_33635	polycyclic compound		
http://purl.obolibrary.org/obo/CHEBI_36841	11-hydroxy steroid	http://purl.obolibrary.org/obo/CHEBI_35350	hydroxy steroid		
http://purl.obolibrary.org/obo/CHEBI_33241	oxoacid derivative	http://purl.obolibrary.org/obo/CHEBI_37577	heteroatomic molecular entity		
http://purl.obolibrary.org/obo/CHEBI_50329	2-carboxyethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50336	4-hydroxybenzyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50331	3-amino-3-oxopropyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50337	1H-indol-3-ylmethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50338	1H-imidazol-4-ylmethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_50341	1-hydroxyethyl group	http://purl.obolibrary.org/obo/CHEBI_50325	proteinogenic amino-acid side-chain group		
http://purl.obolibrary.org/obo/CHEBI_32859	valinate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/HP_0005701	Multiple enchondromatosis	http://purl.obolibrary.org/obo/HP_0002763	Abnormal cartilage morphology		
http://purl.obolibrary.org/obo/HP_0006956	Lateral ventricle dilatation	http://purl.obolibrary.org/obo/HP_0002119	Ventriculomegaly		
http://purl.obolibrary.org/obo/HP_0006051	Metacarpal periosteal thickening	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0006175	Proximal phalangeal periosteal thickening	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0008074	Metatarsal periosteal thickening	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		
http://purl.obolibrary.org/obo/HP_0006763	Anal canal squamous carcinoma	http://purl.obolibrary.org/obo/HP_0030437	Anal canal neoplasm		
http://purl.obolibrary.org/obo/HP_0008045	Enlarged flash visual evoked potentials	http://purl.obolibrary.org/obo/HP_0030462	Abnormal amplitude of flash visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0008275	Abnormal light-adapted electroretinogram	http://purl.obolibrary.org/obo/HP_0030466	Abnormal full-field electroretinogram		
http://purl.obolibrary.org/obo/HP_0008482	Asymmetry of spinal facet joints	http://purl.obolibrary.org/obo/HP_0030870	Abnormality of spinal facet joint		
http://purl.obolibrary.org/obo/HP_0008472	Prominent protruding coccyx	http://purl.obolibrary.org/obo/HP_0040017	Protruding coccyx		
http://purl.obolibrary.org/obo/HP_0040050	Sparse upper eyelashes	http://purl.obolibrary.org/obo/HP_0000653	Sparse eyelashes		
http://purl.obolibrary.org/obo/HP_0040054	Short upper eyelashes	http://purl.obolibrary.org/obo/HP_0010764	Short eyelashes		
http://purl.obolibrary.org/obo/HP_0007776	Sparse lower eyelashes	http://purl.obolibrary.org/obo/HP_0000653	Sparse eyelashes		
http://purl.obolibrary.org/obo/HP_0040053	Long lower eyelashes	http://purl.obolibrary.org/obo/HP_0000527	Long eyelashes		
http://purl.obolibrary.org/obo/HP_0040055	Short lower eyelashes	http://purl.obolibrary.org/obo/HP_0010764	Short eyelashes		
http://purl.obolibrary.org/obo/HP_0040122	Impairment of the the acoustic reflex	http://purl.obolibrary.org/obo/HP_0040121	Abnormality of the acoustic reflex		
http://purl.obolibrary.org/obo/HP_0040158	Short intermamillary distance	http://purl.obolibrary.org/obo/HP_0040157	Abnormal intermamillary distance		
http://purl.obolibrary.org/obo/HP_0040169	Loose anagen hair	http://purl.obolibrary.org/obo/HP_0040170	Abnormality of hair growth		
http://purl.obolibrary.org/obo/HP_0040221	Hypoplasia of the dental root	http://purl.obolibrary.org/obo/HP_0040220	Abnormal size of the dental root		
http://purl.obolibrary.org/obo/HP_0045035	Decreased urinary copper concentration	http://purl.obolibrary.org/obo/HP_0045036	Abnormal urinary copper concentration		
http://purl.obolibrary.org/obo/HP_0009825	Aplasia involving bones of the extremities	http://purl.obolibrary.org/obo/HP_0045060	Aplasia/hypoplasia involving bones of the extremities		
http://purl.obolibrary.org/obo/HP_0200154	Agenesis of mandibular lateral incisor	http://purl.obolibrary.org/obo/HP_0200153	Agenesis of lateral incisor		
http://purl.obolibrary.org/obo/HP_0040032	Hypoplasia of the upper eyelids	http://purl.obolibrary.org/obo/HP_0430009	Hypoplasia of eyelid		
http://purl.obolibrary.org/obo/HP_0005290	Internal carotid artery hypoplasia	http://purl.obolibrary.org/obo/HP_3000062	Abnormal internal carotid artery morphology		
http://purl.obolibrary.org/obo/HP_0005790	Short mandibular condyles	http://purl.obolibrary.org/obo/HP_0003778	Short mandibular rami		
http://purl.obolibrary.org/obo/UBERON_0035005	preputial swelling of male	http://purl.obolibrary.org/obo/UBERON_0035004	preputial swelling		
http://purl.obolibrary.org/obo/HP_0006756	Diffuse leiomyomatosis	http://purl.obolibrary.org/obo/HP_0031459	Soft tissue neoplasm		
http://purl.obolibrary.org/obo/HP_0410375	Increased naive CD4+ T cell proportion	http://purl.obolibrary.org/obo/HP_0410373	Abnormal naive CD4+ T cell proportion		
http://purl.obolibrary.org/obo/HP_0008762	Repetitive compulsive behavior	http://purl.obolibrary.org/obo/HP_0031432	Restricted or repetitive behaviors or interests		
http://purl.obolibrary.org/obo/HP_0011667	Bilateral superior vena cava with bridging vein	http://purl.obolibrary.org/obo/HP_0033379	Bilateral superior vena cava		
http://purl.obolibrary.org/obo/HP_0011668	Bilateral superior vena cava with no bridging vein	http://purl.obolibrary.org/obo/HP_0033379	Bilateral superior vena cava		
http://purl.obolibrary.org/obo/HP_0006094	Finger joint hypermobility	http://purl.obolibrary.org/obo/HP_0006256	Abnormality of hand joint mobility		
http://purl.obolibrary.org/obo/HP_0005340	Spastic/hyperactive bladder	http://purl.obolibrary.org/obo/HP_0000009	Functional abnormality of the bladder		
http://purl.obolibrary.org/obo/HP_0008720	Primary testicular failure	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		
http://purl.obolibrary.org/obo/HP_0010789	Abnormality of the Leydig cells	http://purl.obolibrary.org/obo/HP_0000035	Abnormal testis morphology		
http://purl.obolibrary.org/obo/HP_0032076	Abnormal male urethral meatus morphology	http://purl.obolibrary.org/obo/HP_0000036	Abnormal penis morphology		
http://purl.obolibrary.org/obo/HP_0008656	Incomplete male pseudohermaphroditism	http://purl.obolibrary.org/obo/HP_0000037	Male pseudohermaphroditism		
http://purl.obolibrary.org/obo/HP_0100674	Vaginal hematocele	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		
http://purl.obolibrary.org/obo/HP_0100675	Vaginal pyocele	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		
http://purl.obolibrary.org/obo/HP_0100676	Vaginal lymphocele	http://purl.obolibrary.org/obo/HP_0000045	Abnormal scrotum morphology		
http://purl.obolibrary.org/obo/HP_0008640	Congenital macroorchidism	http://purl.obolibrary.org/obo/HP_0000053	Macroorchidism		
http://purl.obolibrary.org/obo/HP_0040255	Aplasia/Hypoplasia of the clitoris	http://purl.obolibrary.org/obo/HP_0000056	Abnormal clitoris morphology		
http://purl.obolibrary.org/obo/HP_0040252	Abnormal size of the clitoris	http://purl.obolibrary.org/obo/HP_0000056	Abnormal clitoris morphology		
http://purl.obolibrary.org/obo/HP_0008739	Labial pseudohypertrophy	http://purl.obolibrary.org/obo/HP_0000065	Labial hypertrophy		
http://purl.obolibrary.org/obo/HP_0008714	Ureterovesical stenosis	http://purl.obolibrary.org/obo/HP_0000071	Ureteral stenosis		
http://purl.obolibrary.org/obo/HP_0008705	Ureteral triplication	http://purl.obolibrary.org/obo/HP_0000073	Ureteral duplication		
http://purl.obolibrary.org/obo/HP_0030012	Abnormal female reproductive system physiology	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of reproductive system physiology		
http://purl.obolibrary.org/obo/HP_0032628	Renal intratubular crystals	http://purl.obolibrary.org/obo/HP_0000091	Abnormal renal tubule morphology		
http://purl.obolibrary.org/obo/HP_0032583	Renal glomerular foam cells	http://purl.obolibrary.org/obo/HP_0003651	Foam cells		
http://purl.obolibrary.org/obo/HP_0033215	Obliterative abnormality of the renal glomerulus	http://purl.obolibrary.org/obo/HP_0000095	Abnormal renal glomerulus morphology		
http://purl.obolibrary.org/obo/HP_0011407	Proportionate tall stature	http://purl.obolibrary.org/obo/HP_0000098	Tall stature		
http://purl.obolibrary.org/obo/HP_0008695	Transient nephrotic syndrome	http://purl.obolibrary.org/obo/HP_0000100	Nephrotic syndrome		
http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the digestive system	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		
http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		
http://purl.obolibrary.org/obo/HP_0045027	Abnormality of the thoracic cavity	http://purl.obolibrary.org/obo/HP_0000118	Phenotypic abnormality		
http://purl.obolibrary.org/obo/HP_0008272	Renal tubular lysine transport defect	http://purl.obolibrary.org/obo/HP_0000124	Renal tubular dysfunction		
http://purl.obolibrary.org/obo/HP_0032565	Vaginal mucosal ulceration	http://purl.obolibrary.org/obo/HP_0000142	Abnormal vagina morphology		
http://purl.obolibrary.org/obo/HP_0012041	Decreased fertility in males	http://purl.obolibrary.org/obo/HP_0000144	Decreased fertility		
http://purl.obolibrary.org/obo/HP_0008675	Enlarged polycystic ovaries	http://purl.obolibrary.org/obo/HP_0100879	Enlarged ovaries		
http://purl.obolibrary.org/obo/HP_0006326	Buried teeth encased in mucopolysaccharide	http://purl.obolibrary.org/obo/HP_0000164	Abnormality of the dentition		
http://purl.obolibrary.org/obo/HP_0100338	Non-midline cleft palate	http://purl.obolibrary.org/obo/HP_0000175	Cleft palate		
http://purl.obolibrary.org/obo/HP_0410005	Cleft hard palate	http://purl.obolibrary.org/obo/HP_0100737	Abnormal hard palate morphology		
http://purl.obolibrary.org/obo/HP_0005498	Midline skin dimples over anterior/posterior fontanelles	http://purl.obolibrary.org/obo/HP_0000236	Abnormal anterior fontanelle morphology		
http://purl.obolibrary.org/obo/HP_0100955	Giant cell granuloma of mandible	http://purl.obolibrary.org/obo/HP_0000277	Abnormal mandible morphology		
http://purl.obolibrary.org/obo/HP_0005336	Forehead hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0009019	Progressive loss of facial adipose tissue	http://purl.obolibrary.org/obo/HP_0000292	Loss of facial adipose tissue		
http://purl.obolibrary.org/obo/HP_0045037	Abnormality of jaw muscles	http://purl.obolibrary.org/obo/HP_0000301	Abnormality of facial musculature		
http://purl.obolibrary.org/obo/HP_0004676	Prominent supraorbital arches in adult	http://purl.obolibrary.org/obo/HP_0000336	Prominent supraorbital ridges		
http://purl.obolibrary.org/obo/HP_0008541	Superiorly displaced ears	http://purl.obolibrary.org/obo/HP_0000357	Abnormal location of ears		
http://purl.obolibrary.org/obo/HP_0040080	Anteverted ears	http://purl.obolibrary.org/obo/HP_0000357	Abnormal location of ears		
http://purl.obolibrary.org/obo/HP_0040099	Abnormality of the round window	http://purl.obolibrary.org/obo/HP_0000370	Abnormality of the middle ear		
http://purl.obolibrary.org/obo/HP_0040100	Abnormality of the vestibular window	http://purl.obolibrary.org/obo/HP_0000370	Abnormality of the middle ear		
http://purl.obolibrary.org/obo/HP_0005289	Abnormal nasolabial region morphology	http://purl.obolibrary.org/obo/HP_0000366	Abnormality of the nose		
http://purl.obolibrary.org/obo/HP_0008605	Unilateral external ear deformity	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		
http://purl.obolibrary.org/obo/HP_0008608	Hypertrophic auricular cartilage	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		
http://purl.obolibrary.org/obo/HP_0010723	Cystic lesions of the pinnae	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		
http://purl.obolibrary.org/obo/HP_0100830	Round ear	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		
http://purl.obolibrary.org/obo/HP_0040112	Abnormal number of tubercles	http://purl.obolibrary.org/obo/HP_0000377	Abnormal pinna morphology		
http://purl.obolibrary.org/obo/HP_0040101	Cutaneous atresia of the external auditory canal	http://purl.obolibrary.org/obo/HP_0000413	Atresia of the external auditory canal		
http://purl.obolibrary.org/obo/HP_0040102	Osseous atresia of the external auditory canal	http://purl.obolibrary.org/obo/HP_0000413	Atresia of the external auditory canal		
http://purl.obolibrary.org/obo/HP_0005322	Prominent nasal septum	http://purl.obolibrary.org/obo/HP_0000419	Abnormal nasal septum morphology		
http://purl.obolibrary.org/obo/HP_0005281	Hypoplastic nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		
http://purl.obolibrary.org/obo/HP_0005285	Absent nasal bridge	http://purl.obolibrary.org/obo/HP_0000422	Abnormal nasal bridge morphology		
http://purl.obolibrary.org/obo/HP_0005275	Cartilaginous ossification of nose	http://purl.obolibrary.org/obo/HP_0000429	Abnormal morphology of the nasal alae		
http://purl.obolibrary.org/obo/HP_0005274	Prominent nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		
http://purl.obolibrary.org/obo/HP_0005278	Hypoplastic nasal tip	http://purl.obolibrary.org/obo/HP_0000436	Abnormal nasal tip morphology		
http://purl.obolibrary.org/obo/HP_0200138	Bilateral choanal atresia/stenosis	http://purl.obolibrary.org/obo/HP_0004502	Bilateral choanal atresia		
http://purl.obolibrary.org/obo/HP_0010879	Postnatal cystic hygroma	http://purl.obolibrary.org/obo/HP_0000476	Cystic hygroma		
http://purl.obolibrary.org/obo/HP_0007866	Retinal infarction	http://purl.obolibrary.org/obo/HP_0000479	Abnormal retinal morphology		
http://purl.obolibrary.org/obo/HP_0008061	Aplasia/Hypoplasia of the retina	http://purl.obolibrary.org/obo/HP_0008057	Aplasia/Hypoplasia affecting the fundus		
http://purl.obolibrary.org/obo/HP_0007705	Corneal degeneration	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		
http://purl.obolibrary.org/obo/HP_0040004	Abnormality of corneal shape	http://purl.obolibrary.org/obo/HP_0000481	Abnormal cornea morphology		
http://purl.obolibrary.org/obo/HP_0007406	Hyperpigmentation of eyelids	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0008496	Multiple rows of eyelashes	http://purl.obolibrary.org/obo/HP_0000499	Abnormal eyelash morphology		
http://purl.obolibrary.org/obo/HP_0030512	Difficulty adjusting to changes in luminance	http://purl.obolibrary.org/obo/HP_0000504	Abnormality of vision		
http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity	http://purl.obolibrary.org/obo/HP_0000505	Visual impairment		
http://purl.obolibrary.org/obo/HP_0030468	Abnormal multifocal electroretinogram	http://purl.obolibrary.org/obo/HP_0000512	Abnormal electroretinogram		
http://purl.obolibrary.org/obo/HP_0007905	Abnormal iris vasculature	http://purl.obolibrary.org/obo/HP_0008047	Abnormality of the vasculature of the eye		
http://purl.obolibrary.org/obo/HP_0007740	Long eyelashes in irregular rows	http://purl.obolibrary.org/obo/HP_0000527	Long eyelashes		
http://purl.obolibrary.org/obo/HP_0007924	Slow decrease in visual acuity	http://purl.obolibrary.org/obo/HP_0000529	Progressive visual loss		
http://purl.obolibrary.org/obo/HP_0007661	Abnormality of chorioretinal pigmentation	http://purl.obolibrary.org/obo/HP_0000532	Abnormal chorioretinal morphology		
http://purl.obolibrary.org/obo/HP_0007733	Laterally curved eyebrow	http://purl.obolibrary.org/obo/HP_0000534	Abnormal eyebrow morphology		
http://purl.obolibrary.org/obo/HP_0030584	Color vision test abnormality	http://purl.obolibrary.org/obo/HP_0000551	Color vision defect		
http://purl.obolibrary.org/obo/HP_0007708	Absent inner eyelashes	http://purl.obolibrary.org/obo/HP_0000561	Absent eyelashes		
http://purl.obolibrary.org/obo/HP_0040056	Absent upper eyelashes	http://purl.obolibrary.org/obo/HP_0000561	Absent eyelashes		
http://purl.obolibrary.org/obo/HP_0030528	Paracentral scotoma	http://purl.obolibrary.org/obo/HP_0000575	Scotoma		
http://purl.obolibrary.org/obo/HP_0030530	Arcuate scotoma	http://purl.obolibrary.org/obo/HP_0000575	Scotoma		
http://purl.obolibrary.org/obo/HP_0007807	Optic nerve compression	http://purl.obolibrary.org/obo/HP_0001293	Cranial nerve compression		
http://purl.obolibrary.org/obo/HP_0007832	Pigmentation of the sclera	http://purl.obolibrary.org/obo/HP_0000591	Abnormal sclera morphology		
http://purl.obolibrary.org/obo/HP_0100011	Scleral schwannoma	http://purl.obolibrary.org/obo/HP_0100012	Neoplasm of the eye		
http://purl.obolibrary.org/obo/HP_0007833	Anterior chamber synechiae	http://purl.obolibrary.org/obo/HP_0000593	Abnormal anterior chamber morphology		
http://purl.obolibrary.org/obo/HP_0007715	Weak extraocular muscles	http://purl.obolibrary.org/obo/HP_0000597	Ophthalmoparesis		
http://purl.obolibrary.org/obo/HP_0008507	Static ophthalmoparesis	http://purl.obolibrary.org/obo/HP_0000597	Ophthalmoparesis		
http://purl.obolibrary.org/obo/HP_0006783	Posterior pharyngeal cleft	http://purl.obolibrary.org/obo/HP_0000600	Abnormality of the pharynx		
http://purl.obolibrary.org/obo/HP_0007650	Progressive ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0000602	Ophthalmoplegia		
http://purl.obolibrary.org/obo/HP_0007668	Impaired pursuit initiation and maintenance	http://purl.obolibrary.org/obo/HP_0000617	Abnormality of ocular smooth pursuit		
http://purl.obolibrary.org/obo/HP_0008003	Jerky ocular pursuit movements	http://purl.obolibrary.org/obo/HP_0000617	Abnormality of ocular smooth pursuit		
http://purl.obolibrary.org/obo/HP_0008030	Retinal arteritis	http://purl.obolibrary.org/obo/HP_0025188	Retinal vasculitis		
http://purl.obolibrary.org/obo/HP_0007965	Undetectable visual evoked potentials	http://purl.obolibrary.org/obo/HP_0000649	Abnormality of visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030455	Abnormality of pattern visual evoked potentials	http://purl.obolibrary.org/obo/HP_0000649	Abnormality of visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0007651	Ectropion of lower eyelids	http://purl.obolibrary.org/obo/HP_0000656	Ectropion		
http://purl.obolibrary.org/obo/HP_0007655	Eversion of lateral third of lower eyelids	http://purl.obolibrary.org/obo/HP_0000656	Ectropion		
http://purl.obolibrary.org/obo/HP_0007675	Progressive night blindness	http://purl.obolibrary.org/obo/HP_0000662	Nyctalopia		
http://purl.obolibrary.org/obo/HP_0007747	Monocular horizontal nystagmus	http://purl.obolibrary.org/obo/HP_0000666	Horizontal nystagmus		
http://purl.obolibrary.org/obo/HP_0008026	Horizontal opticokinetic nystagmus	http://purl.obolibrary.org/obo/HP_0000666	Horizontal nystagmus		
http://purl.obolibrary.org/obo/HP_0200141	Small, conical teeth	http://purl.obolibrary.org/obo/HP_0000698	Conical tooth		
http://purl.obolibrary.org/obo/HP_0006291	Marked delay in eruption of permanent teeth	http://purl.obolibrary.org/obo/HP_0000696	Delayed eruption of permanent teeth		
http://purl.obolibrary.org/obo/HP_0006321	Multiple non-erupting secondary teeth	http://purl.obolibrary.org/obo/HP_0000696	Delayed eruption of permanent teeth		
http://purl.obolibrary.org/obo/HP_0040078	Axonal degeneration	http://purl.obolibrary.org/obo/HP_0000764	Peripheral axonal degeneration		
http://purl.obolibrary.org/obo/HP_0006711	Aplasia/Hypoplasia involving bones of the thorax	http://purl.obolibrary.org/obo/HP_0009122	Aplasia/hypoplasia affecting bones of the axial skeleton		
http://purl.obolibrary.org/obo/HP_0006637	Sternal punctate calcifications	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		
http://purl.obolibrary.org/obo/HP_0005820	Superior rib anomalies	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		
http://purl.obolibrary.org/obo/HP_0006593	Anomalous rib insertion to vertebrae	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		
http://purl.obolibrary.org/obo/HP_0006641	Prominent floating ribs	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		
http://purl.obolibrary.org/obo/HP_0006655	Rib segmentation abnormalities	http://purl.obolibrary.org/obo/HP_0000772	Abnormal rib morphology		
http://purl.obolibrary.org/obo/HP_0006657	Hypoplasia of first ribs	http://purl.obolibrary.org/obo/HP_0000773	Short ribs		
http://purl.obolibrary.org/obo/HP_0006668	Twelfth rib hypoplasia	http://purl.obolibrary.org/obo/HP_0000773	Short ribs		
http://purl.obolibrary.org/obo/HP_0040045	Abnormal hemidiaphragm morphology	http://purl.obolibrary.org/obo/HP_0000775	Abnormality of the diaphragm		
http://purl.obolibrary.org/obo/HP_0006650	Thickening of the lateral border of the scapula	http://purl.obolibrary.org/obo/HP_0000782	Abnormal scapula morphology		
http://purl.obolibrary.org/obo/HP_0008222	Female infertility	http://purl.obolibrary.org/obo/HP_0000868	Decreased fertility in females		
http://purl.obolibrary.org/obo/HP_0008651	Uric acid urolithiasis independent of gout	http://purl.obolibrary.org/obo/HP_0000791	Uric acid nephrolithiasis		
http://purl.obolibrary.org/obo/HP_0008706	Distal urethral duplication	http://purl.obolibrary.org/obo/HP_0000795	Abnormality of the urethra		
http://purl.obolibrary.org/obo/HP_0008639	Gonadal hypoplasia	http://purl.obolibrary.org/obo/HP_0000812	Abnormal internal genitalia		
http://purl.obolibrary.org/obo/HP_0008702	Absent internal genitalia	http://purl.obolibrary.org/obo/HP_0000812	Abnormal internal genitalia		
http://purl.obolibrary.org/obo/HP_0100735	Hypertensive crisis	http://purl.obolibrary.org/obo/HP_0000822	Hypertension		
http://purl.obolibrary.org/obo/HP_0008240	Secondary growth hormone deficiency	http://purl.obolibrary.org/obo/HP_0000824	Decreased response to growth hormone stimulation test		
http://purl.obolibrary.org/obo/HP_0008204	Precocious puberty with Sertoli cell tumor	http://purl.obolibrary.org/obo/HP_0100619	Sertoli cell neoplasm		
http://purl.obolibrary.org/obo/HP_0008236	Isosexual precocious puberty	http://purl.obolibrary.org/obo/HP_0000826	Precocious puberty		
http://purl.obolibrary.org/obo/HP_0011782	Thyroid crisis	http://purl.obolibrary.org/obo/HP_0000836	Hyperthyroidism		
http://purl.obolibrary.org/obo/HP_0011783	Thyrotoxicosis from ectopic thyroid tissue	http://purl.obolibrary.org/obo/HP_0000836	Hyperthyroidism		
http://purl.obolibrary.org/obo/HP_0011784	Thyrotoxicosis with diffuse goiter	http://purl.obolibrary.org/obo/HP_0000836	Hyperthyroidism		
http://purl.obolibrary.org/obo/HP_0011785	Thyrotoxicosis with toxic multinodular goiter	http://purl.obolibrary.org/obo/HP_0000836	Hyperthyroidism		
http://purl.obolibrary.org/obo/HP_0011786	Thyrotoxicosis with toxic single thyroid nodule	http://purl.obolibrary.org/obo/HP_0000836	Hyperthyroidism		
http://purl.obolibrary.org/obo/HP_0040085	Abnormal circulating aldosterone concentration	http://purl.obolibrary.org/obo/HP_0000847	Abnormality of renin-angiotensin system		
http://purl.obolibrary.org/obo/HP_0008182	Adrenocortical hypoplasia	http://purl.obolibrary.org/obo/HP_0000849	Adrenocortical abnormality		
http://purl.obolibrary.org/obo/HP_0011774	Thyroid follicular adenoma	http://purl.obolibrary.org/obo/HP_0000854	Thyroid adenoma		
http://purl.obolibrary.org/obo/HP_0011777	Thyroid papillary adenoma	http://purl.obolibrary.org/obo/HP_0000854	Thyroid adenoma		
http://purl.obolibrary.org/obo/HP_0011778	Thyroid atypical adenoma	http://purl.obolibrary.org/obo/HP_0000854	Thyroid adenoma		
http://purl.obolibrary.org/obo/HP_0008255	Transient neonatal diabetes mellitus	http://purl.obolibrary.org/obo/HP_0000857	Neonatal insulin-dependent diabetes mellitus		
http://purl.obolibrary.org/obo/HP_0006584	Small abnormally formed scapulae	http://purl.obolibrary.org/obo/HP_0000882	Hypoplastic scapulae		
http://purl.obolibrary.org/obo/HP_0006631	Hypoplastic distal segments of scapulae	http://purl.obolibrary.org/obo/HP_0000882	Hypoplastic scapulae		
http://purl.obolibrary.org/obo/HP_0006603	Flared, irregular rib ends	http://purl.obolibrary.org/obo/HP_0000887	Cupped ribs		
http://purl.obolibrary.org/obo/HP_0006599	Medial widening of clavicle	http://purl.obolibrary.org/obo/HP_0000889	Abnormal clavicle morphology		
http://purl.obolibrary.org/obo/HP_0006589	Flaring of lower rib cage	http://purl.obolibrary.org/obo/HP_0000904	Flaring of rib cage		
http://purl.obolibrary.org/obo/HP_0006600	Progressive calcification of costochondral cartilage	http://purl.obolibrary.org/obo/HP_0100593	Calcification of cartilage		
http://purl.obolibrary.org/obo/HP_0005881	Spinal instability	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		
http://purl.obolibrary.org/obo/HP_0008433	Reversed usual vertebral column curves	http://purl.obolibrary.org/obo/HP_0000925	Abnormality of the vertebral column		
http://purl.obolibrary.org/obo/HP_0009116	Aplasia/Hypoplasia involving bones of the skull	http://purl.obolibrary.org/obo/HP_0009122	Aplasia/hypoplasia affecting bones of the axial skeleton		
http://purl.obolibrary.org/obo/HP_0005017	Polyarticular chondrocalcinosis	http://purl.obolibrary.org/obo/HP_0000934	Chondrocalcinosis		
http://purl.obolibrary.org/obo/HP_0006440	Increased density of long bone diaphyses	http://purl.obolibrary.org/obo/HP_0006392	Increased density of long bones		
http://purl.obolibrary.org/obo/HP_0100252	Diaphyseal dysplasia	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		
http://purl.obolibrary.org/obo/HP_0006490	Abnormal lower-limb metaphysis morphology	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		
http://purl.obolibrary.org/obo/HP_0008821	Hypoplastic inferior ilia	http://purl.obolibrary.org/obo/HP_0000946	Hypoplastic ilia		
http://purl.obolibrary.org/obo/HP_0005586	Hyperpigmentation in sun-exposed areas	http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0007440	Generalized hyperpigmentation	http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0007505	Progressive hyperpigmentation	http://purl.obolibrary.org/obo/HP_0000953	Hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0009123	Mixed hypo- and hyperpigmentation of the skin	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0200048	Cyanotic episode	http://purl.obolibrary.org/obo/HP_0000961	Cyanosis		
http://purl.obolibrary.org/obo/HP_0007480	Decreased sweating due to autonomic dysfunction	http://purl.obolibrary.org/obo/HP_0000966	Hypohidrosis		
http://purl.obolibrary.org/obo/HP_0007476	Anhidrotic ectodermal dysplasia	http://purl.obolibrary.org/obo/HP_0000968	Ectodermal dysplasia		
http://purl.obolibrary.org/obo/HP_0007529	Hidrotic ectodermal dysplasia	http://purl.obolibrary.org/obo/HP_0000968	Ectodermal dysplasia		
http://purl.obolibrary.org/obo/HP_0007607	Hypohidrotic ectodermal dysplasia	http://purl.obolibrary.org/obo/HP_0000968	Ectodermal dysplasia		
http://purl.obolibrary.org/obo/HP_0007458	Focal hyperextensible skin	http://purl.obolibrary.org/obo/HP_0000974	Hyperextensible skin		
http://purl.obolibrary.org/obo/HP_0004552	Scarring alopecia of scalp	http://purl.obolibrary.org/obo/HP_0002293	Alopecia of scalp		
http://purl.obolibrary.org/obo/HP_0010562	Keloids	http://purl.obolibrary.org/obo/HP_0000987	Atypical scarring of skin		
http://purl.obolibrary.org/obo/HP_0005603	Numerous congenital melanocytic nevi	http://purl.obolibrary.org/obo/HP_0000995	Melanocytic nevus		
http://purl.obolibrary.org/obo/HP_0005606	Hyperpigmented nevi and streak	http://purl.obolibrary.org/obo/HP_0000995	Melanocytic nevus		
http://purl.obolibrary.org/obo/HP_0007481	Hyperpigmented nevi	http://purl.obolibrary.org/obo/HP_0000995	Melanocytic nevus		
http://purl.obolibrary.org/obo/HP_0007452	Midface capillary hemangioma	http://purl.obolibrary.org/obo/HP_0000996	Facial capillary hemangioma		
http://purl.obolibrary.org/obo/HP_0007466	Midfrontal capillary hemangioma	http://purl.obolibrary.org/obo/HP_0000996	Facial capillary hemangioma		
http://purl.obolibrary.org/obo/HP_0007601	Midline facial capillary hemangioma	http://purl.obolibrary.org/obo/HP_0000996	Facial capillary hemangioma		
http://purl.obolibrary.org/obo/HP_0007525	Yellow subcutaneous tissue covered by thin, scaly skin	http://purl.obolibrary.org/obo/HP_0001001	Abnormality of subcutaneous fat tissue		
http://purl.obolibrary.org/obo/HP_0007552	Abnormal subcutaneous fat tissue distribution	http://purl.obolibrary.org/obo/HP_0001001	Abnormality of subcutaneous fat tissue		
http://purl.obolibrary.org/obo/HP_0007583	Telangiectasia macularis eruptiva perstans	http://purl.obolibrary.org/obo/HP_0001009	Telangiectasia		
http://purl.obolibrary.org/obo/HP_0007535	Hypopigmented streaks	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0007554	Confetti hypopigmentation pattern of lower leg skin	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0006773	Cutaneous angiolipomas	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		
http://purl.obolibrary.org/obo/HP_0005689	Dermatoglyphic ridges abnormal	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0005875	Increased dermatoglyphic whorls	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0005882	Dermatoglyphic variants	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0006189	Prominent interdigital folds	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0007602	Complex palmar dermatoglyphic pattern	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0007608	Abnormal palmar dermal ridges	http://purl.obolibrary.org/obo/HP_0001018	Abnormal palmar dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0007381	Congenital exfoliative erythroderma	http://purl.obolibrary.org/obo/HP_0001019	Erythroderma		
http://purl.obolibrary.org/obo/HP_0007461	Hemangiomatosis	http://purl.obolibrary.org/obo/HP_0001028	Hemangioma		
http://purl.obolibrary.org/obo/HP_0007585	Skin fragility with non-scarring blistering	http://purl.obolibrary.org/obo/HP_0001030	Fragile skin		
http://purl.obolibrary.org/obo/HP_0007412	Macular hyperpigmented dermopathy	http://purl.obolibrary.org/obo/HP_0001034	Hypermelanotic macule		
http://purl.obolibrary.org/obo/HP_0005602	Progressive vitiligo	http://purl.obolibrary.org/obo/HP_0001045	Vitiligo		
http://purl.obolibrary.org/obo/HP_0007486	Cavernous hemangioma of the face	http://purl.obolibrary.org/obo/HP_0001048	Cavernous hemangioma		
http://purl.obolibrary.org/obo/HP_0005590	Spotty hypopigmentation	http://purl.obolibrary.org/obo/HP_0001053	Hypopigmented skin patches		
http://purl.obolibrary.org/obo/HP_0005593	Macular hypopigmented whorls, streaks, and patches	http://purl.obolibrary.org/obo/HP_0001053	Hypopigmented skin patches		
http://purl.obolibrary.org/obo/HP_0007526	Hypopigmented skin patches on arms	http://purl.obolibrary.org/obo/HP_0001053	Hypopigmented skin patches		
http://purl.obolibrary.org/obo/HP_0005220	Multiple intestinal neurofibromatosis	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		
http://purl.obolibrary.org/obo/HP_0007524	Atypical neurofibromatosis	http://purl.obolibrary.org/obo/HP_0001067	Neurofibroma		
http://purl.obolibrary.org/obo/HP_0007438	Mottled pigmentation of the trunk and proximal extremities	http://purl.obolibrary.org/obo/HP_0001070	Mottled pigmentation		
http://purl.obolibrary.org/obo/HP_0007511	Mottled pigmentation of photoexposed areas	http://purl.obolibrary.org/obo/HP_0001070	Mottled pigmentation		
http://purl.obolibrary.org/obo/HP_0008007	Primary congenital glaucoma	http://purl.obolibrary.org/obo/HP_0001087	Developmental glaucoma		
http://purl.obolibrary.org/obo/HP_0008041	Late onset congenital glaucoma	http://purl.obolibrary.org/obo/HP_0001087	Developmental glaucoma		
http://purl.obolibrary.org/obo/HP_0007854	Glaucomatous visual field defect	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		
http://purl.obolibrary.org/obo/HP_0007987	Progressive visual field defects	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		
http://purl.obolibrary.org/obo/HP_0030531	Altitudinal visual field defect	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		
http://purl.obolibrary.org/obo/HP_0030644	Blind-spot enlargement	http://purl.obolibrary.org/obo/HP_0001123	Visual field defect		
http://purl.obolibrary.org/obo/HP_0007809	Punctate corneal dystrophy	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		
http://purl.obolibrary.org/obo/HP_0007836	Mosaic corneal dystrophy	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		
http://purl.obolibrary.org/obo/HP_0007880	Marginal corneal dystrophy	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		
http://purl.obolibrary.org/obo/HP_0007962	Speckled corneal dystrophy	http://purl.obolibrary.org/obo/HP_0001131	Corneal dystrophy		
http://purl.obolibrary.org/obo/HP_0007822	Central retinal exudate	http://purl.obolibrary.org/obo/HP_0001147	Retinal exudate		
http://purl.obolibrary.org/obo/HP_0007792	Microsaccadic pursuit	http://purl.obolibrary.org/obo/HP_0001152	Saccadic smooth pursuit interruptions		
http://purl.obolibrary.org/obo/HP_0007944	Intermittent microsaccadic pursuits	http://purl.obolibrary.org/obo/HP_0001152	Saccadic smooth pursuit interruptions		
http://purl.obolibrary.org/obo/HP_0008670	Partial vaginal septum	http://purl.obolibrary.org/obo/HP_0001153	Septate vagina		
http://purl.obolibrary.org/obo/HP_0006256	Abnormality of hand joint mobility	http://purl.obolibrary.org/obo/HP_0011729	Abnormality of joint mobility		
http://purl.obolibrary.org/obo/HP_0005831	Type B brachydactyly	http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly		
http://purl.obolibrary.org/obo/HP_0006008	Unilateral brachydactyly	http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly		
http://purl.obolibrary.org/obo/HP_0009370	Type A brachydactyly	http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly		
http://purl.obolibrary.org/obo/HP_0009373	Type C brachydactyly	http://purl.obolibrary.org/obo/HP_0001156	Brachydactyly		
http://purl.obolibrary.org/obo/HP_0005676	Rudimentary postaxial polydactyly of hands	http://purl.obolibrary.org/obo/HP_0001162	Postaxial hand polydactyly		
http://purl.obolibrary.org/obo/HP_0006136	Bilateral postaxial polydactyly	http://purl.obolibrary.org/obo/HP_0001162	Postaxial hand polydactyly		
http://purl.obolibrary.org/obo/HP_0004095	Curved fingers	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		
http://purl.obolibrary.org/obo/HP_0004188	Abnormal 4th finger morphology	http://purl.obolibrary.org/obo/HP_0001167	Abnormal finger morphology		
http://purl.obolibrary.org/obo/HP_0005190	Proximal finger joint hyperextensibility	http://purl.obolibrary.org/obo/HP_0001187	Hyperextensibility of the finger joints		
http://purl.obolibrary.org/obo/HP_0004239	Proximally placed carpal bones	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		
http://purl.obolibrary.org/obo/HP_0004264	Narrow carpal joint spaces	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		
http://purl.obolibrary.org/obo/HP_0005776	Carpal bone malsegmentation	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		
http://purl.obolibrary.org/obo/HP_0006014	Abnormally shaped carpal bones	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		
http://purl.obolibrary.org/obo/HP_0006180	Crowded carpal bones	http://purl.obolibrary.org/obo/HP_0001191	Abnormal carpal morphology		
http://purl.obolibrary.org/obo/HP_0030917	Low APGAR score	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of prenatal development or birth		
http://purl.obolibrary.org/obo/HP_0007020	Progressive spastic paraplegia	http://purl.obolibrary.org/obo/HP_0001258	Spastic paraplegia		
http://purl.obolibrary.org/obo/HP_0007326	Progressive choreoathetosis	http://purl.obolibrary.org/obo/HP_0001266	Choreoathetosis		
http://purl.obolibrary.org/obo/HP_0007086	Social and occupational deterioration	http://purl.obolibrary.org/obo/HP_0001268	Mental deterioration		
http://purl.obolibrary.org/obo/HP_0200011	Abnormal length of corpus callosum	http://purl.obolibrary.org/obo/HP_0001273	Abnormal corpus callosum morphology		
http://purl.obolibrary.org/obo/HP_0004926	Orthostatic hypotension due to autonomic dysfunction	http://purl.obolibrary.org/obo/HP_0001278	Orthostatic hypotension		
http://purl.obolibrary.org/obo/HP_0005307	Postural hypotension with compensatory tachycardia	http://purl.obolibrary.org/obo/HP_0001278	Orthostatic hypotension		
http://purl.obolibrary.org/obo/HP_0007097	Cranial nerve motor loss	http://purl.obolibrary.org/obo/HP_0001291	Abnormal cranial nerve morphology		
http://purl.obolibrary.org/obo/HP_0007958	Optic atrophy from cranial nerve compression	http://purl.obolibrary.org/obo/HP_0000648	Optic atrophy		
http://purl.obolibrary.org/obo/HP_0006789	Mitochondrial encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		
http://purl.obolibrary.org/obo/HP_0006846	Acute encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		
http://purl.obolibrary.org/obo/HP_0007030	Nonprogressive encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		
http://purl.obolibrary.org/obo/HP_0007239	Congenital encephalopathy	http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy		
http://purl.obolibrary.org/obo/HP_0030178	Abnormality of central nervous system electrophysiology	http://purl.obolibrary.org/obo/HP_0001311	Abnormal nervous system electrophysiology		
http://purl.obolibrary.org/obo/HP_0006899	Fusion of the cerebellar hemispheres	http://purl.obolibrary.org/obo/HP_0001317	Abnormal cerebellum morphology		
http://purl.obolibrary.org/obo/HP_0100307	Cerebellar hemisphere hypoplasia	http://purl.obolibrary.org/obo/HP_0001321	Cerebellar hypoplasia		
http://purl.obolibrary.org/obo/HP_0007000	Morning myoclonic jerks	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		
http://purl.obolibrary.org/obo/HP_0045084	Limb myoclonus	http://purl.obolibrary.org/obo/HP_0001336	Myoclonus		
http://purl.obolibrary.org/obo/HP_0032475	6-layered lissencephaly	http://purl.obolibrary.org/obo/HP_0001339	Lissencephaly		
http://purl.obolibrary.org/obo/HP_0006801	Hyperactive deep tendon reflexes	http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia		
http://purl.obolibrary.org/obo/HP_0007034	Generalized hyperreflexia	http://purl.obolibrary.org/obo/HP_0001347	Hyperreflexia		
http://purl.obolibrary.org/obo/HP_0007164	Slowed slurred speech	http://purl.obolibrary.org/obo/HP_0001350	Slurred speech		
http://purl.obolibrary.org/obo/HP_0005187	Progressive joint destruction	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		
http://purl.obolibrary.org/obo/HP_0025850	Abnormal synovial cavity morphology	http://purl.obolibrary.org/obo/HP_0001367	Abnormal joint morphology		
http://purl.obolibrary.org/obo/HP_0004631	Decreased cervical spine flexion due to contractures of posterior cervical muscles	http://purl.obolibrary.org/obo/HP_0001371	Flexion contracture		
http://purl.obolibrary.org/obo/HP_0005781	Contractures of the large joints	http://purl.obolibrary.org/obo/HP_0001371	Flexion contracture		
http://purl.obolibrary.org/obo/HP_0008780	Congenital bilateral hip dislocation	http://purl.obolibrary.org/obo/HP_0001374	Congenital hip dislocation		
http://purl.obolibrary.org/obo/HP_0005193	Restricted large joint movement	http://purl.obolibrary.org/obo/HP_0001376	Limitation of joint mobility		
http://purl.obolibrary.org/obo/HP_0006064	Limited interphalangeal movement	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006203	Decreased movement range in interphalangeal joints	http://purl.obolibrary.org/obo/HP_0006135	Decreased finger mobility		
http://purl.obolibrary.org/obo/HP_0006596	Restricted chest movement	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		
http://purl.obolibrary.org/obo/HP_0005060	Limited elbow flexion/extension	http://purl.obolibrary.org/obo/HP_0006376	Limited elbow flexion		
http://purl.obolibrary.org/obo/HP_0005852	Limited elbow extension and supination	http://purl.obolibrary.org/obo/HP_0001377	Limited elbow extension		
http://purl.obolibrary.org/obo/HP_0006583	Fatal liver failure in infancy	http://purl.obolibrary.org/obo/HP_0001399	Hepatic failure		
http://purl.obolibrary.org/obo/HP_0100626	Chronic hepatic failure	http://purl.obolibrary.org/obo/HP_0001399	Hepatic failure		
http://purl.obolibrary.org/obo/HP_0006575	Intrahepatic cholestasis with episodic jaundice	http://purl.obolibrary.org/obo/HP_0001406	Intrahepatic cholestasis		
http://purl.obolibrary.org/obo/HP_0006006	Hypotrophy of the small hand muscles	http://purl.obolibrary.org/obo/HP_0001421	Abnormality of the musculature of the hand		
http://purl.obolibrary.org/obo/HP_0009005	Weakness of the intrinsic hand muscles	http://purl.obolibrary.org/obo/HP_0001421	Abnormality of the musculature of the hand		
http://purl.obolibrary.org/obo/HP_0009054	Scapuloperoneal myopathy	http://purl.obolibrary.org/obo/HP_0001465	Amyotrophy involving the shoulder musculature		
http://purl.obolibrary.org/obo/HP_0005258	Pectoral muscle hypoplasia/aplasia	http://purl.obolibrary.org/obo/HP_0001435	Abnormality of the shoulder girdle musculature		
http://purl.obolibrary.org/obo/HP_0008969	Leg muscle stiffness	http://purl.obolibrary.org/obo/HP_0003552	Muscle stiffness		
http://purl.obolibrary.org/obo/HP_0100329	Tarsometatarsal synostosis	http://purl.obolibrary.org/obo/HP_0008368	Tarsal synostosis		
http://purl.obolibrary.org/obo/HP_0009013	Congenital absence of gluteal muscles	http://purl.obolibrary.org/obo/HP_0001471	Aplasia/Hypoplasia of the musculature of the pelvis		
http://purl.obolibrary.org/obo/HP_0007911	Congenital bilateral ptosis	http://purl.obolibrary.org/obo/HP_0007970	Congenital ptosis		
http://purl.obolibrary.org/obo/HP_0004238	Lytic defects of carpal bones	http://purl.obolibrary.org/obo/HP_0001495	Carpal osteolysis		
http://purl.obolibrary.org/obo/HP_0006644	Thoracic dysplasia	http://purl.obolibrary.org/obo/HP_0001547	Abnormal rib cage morphology		
http://purl.obolibrary.org/obo/HP_0005229	Jejunoileal ulceration	http://purl.obolibrary.org/obo/HP_0034274	Gastrointestinal ulcer		
http://purl.obolibrary.org/obo/HP_0032277	Lozenge-shaped umbilicus	http://purl.obolibrary.org/obo/HP_0001551	Abnormal umbilicus morphology		
http://purl.obolibrary.org/obo/HP_0007595	Redundant skin in infancy	http://purl.obolibrary.org/obo/HP_0001582	Redundant skin		
http://purl.obolibrary.org/obo/HP_0100605	Neoplasm of the larynx	http://purl.obolibrary.org/obo/HP_0100606	Neoplasm of the respiratory system		
http://purl.obolibrary.org/obo/HP_0004894	Laryngotracheal stenosis	http://purl.obolibrary.org/obo/HP_0002777	Tracheal stenosis		
http://purl.obolibrary.org/obo/HP_0005100	Premature birth following premature rupture of fetal membranes	http://purl.obolibrary.org/obo/HP_0001788	Premature rupture of membranes		
http://purl.obolibrary.org/obo/HP_0005267	Premature delivery because of cervical insufficiency or membrane fragility	http://purl.obolibrary.org/obo/HP_0001622	Premature birth		
http://purl.obolibrary.org/obo/HP_0011676	Tetralogy of Fallot with absent subarterial conus	http://purl.obolibrary.org/obo/HP_0001636	Tetralogy of Fallot		
http://purl.obolibrary.org/obo/HP_0011677	Tetralogy of Fallot with atrioventricular canal defect	http://purl.obolibrary.org/obo/HP_0001636	Tetralogy of Fallot		
http://purl.obolibrary.org/obo/HP_0004761	Post-angioplasty coronary artery restenosis	http://purl.obolibrary.org/obo/HP_0001677	Coronary artery atherosclerosis		
http://purl.obolibrary.org/obo/HP_0006681	Absent atrioventricular node	http://purl.obolibrary.org/obo/HP_0001678	Atrioventricular block		
http://purl.obolibrary.org/obo/HP_0011699	Atrial reentry tachycardia	http://purl.obolibrary.org/obo/HP_0001692	Atrial arrhythmia		
http://purl.obolibrary.org/obo/HP_0011725	Chaotic multifocal atrial tachycardia	http://purl.obolibrary.org/obo/HP_0001692	Atrial arrhythmia		
http://purl.obolibrary.org/obo/HP_0005129	Congenital hypertrophy of left ventricle	http://purl.obolibrary.org/obo/HP_0001712	Left ventricular hypertrophy		
http://purl.obolibrary.org/obo/HP_0100630	Neoplasia of the nasopharynx	http://purl.obolibrary.org/obo/HP_0100606	Neoplasm of the respiratory system		
http://purl.obolibrary.org/obo/HP_0011680	Single ventricle of indeterminate morphology	http://purl.obolibrary.org/obo/HP_0001750	Single ventricle		
http://purl.obolibrary.org/obo/HP_0008082	Medial deviation of the foot	http://purl.obolibrary.org/obo/HP_0001760	Abnormal foot morphology		
http://purl.obolibrary.org/obo/HP_0008090	Ankylosis of feet small joints	http://purl.obolibrary.org/obo/HP_0031013	Ankylosis		
http://purl.obolibrary.org/obo/HP_0008141	Dislocation of toes	http://purl.obolibrary.org/obo/HP_0030311	Lower extremity joint dislocation		
http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology	http://purl.obolibrary.org/obo/HP_0010631	Abnormality of the epiphyses of the feet		
http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		
http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes	http://purl.obolibrary.org/obo/HP_0001780	Abnormal toe morphology		
http://purl.obolibrary.org/obo/HP_0011411	Forceps delivery	http://purl.obolibrary.org/obo/HP_0001787	Abnormal delivery		
http://purl.obolibrary.org/obo/HP_0008407	Hyperconvex thumb nails	http://purl.obolibrary.org/obo/HP_0001795	Hyperconvex nail		
http://purl.obolibrary.org/obo/HP_0200105	Absent fifth toenail	http://purl.obolibrary.org/obo/HP_0001802	Absent toenail		
http://purl.obolibrary.org/obo/HP_0008078	Thin metatarsal cortices	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		
http://purl.obolibrary.org/obo/HP_0008102	Expanded metatarsals with widened medullary cavities	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		
http://purl.obolibrary.org/obo/HP_0008125	Second metatarsal posteriorly placed	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		
http://purl.obolibrary.org/obo/HP_0008133	Distal tapering of metatarsals	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		
http://purl.obolibrary.org/obo/HP_0040035	Abnormality of the fourth metatarsal bone	http://purl.obolibrary.org/obo/HP_0001832	Abnormal metatarsal morphology		
http://purl.obolibrary.org/obo/HP_0010056	Abnormality of the epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010057	Abnormal hallux phalanx morphology	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0200054	Foot monodactyly	http://purl.obolibrary.org/obo/HP_0001849	Foot oligodactyly		
http://purl.obolibrary.org/obo/HP_0004679	Large tarsal bones	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		
http://purl.obolibrary.org/obo/HP_0004688	Irregular tarsal bones	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		
http://purl.obolibrary.org/obo/HP_0008119	Deformed tarsal bones	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		
http://purl.obolibrary.org/obo/HP_0008144	Flattening of the talar dome	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		
http://purl.obolibrary.org/obo/HP_0100339	Abnormality of the os naviculare pedis	http://purl.obolibrary.org/obo/HP_0001850	Abnormality of the tarsal bones		
http://purl.obolibrary.org/obo/HP_0040018	Clinodactyly of hallux	http://purl.obolibrary.org/obo/HP_0010051	Deviation of the hallux		
http://purl.obolibrary.org/obo/HP_0012134	Dysplastic erythropoesis	http://purl.obolibrary.org/obo/HP_0001877	Abnormal erythrocyte morphology		
http://purl.obolibrary.org/obo/HP_0004863	Compensated hemolytic anemia	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		
http://purl.obolibrary.org/obo/HP_0005524	Macrocytic hemolytic disease	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		
http://purl.obolibrary.org/obo/HP_0005525	Spontaneous hemolytic crises	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		
http://purl.obolibrary.org/obo/HP_0008269	Increased red cell hemolysis by shear stress	http://purl.obolibrary.org/obo/HP_0001878	Hemolytic anemia		
http://purl.obolibrary.org/obo/HP_0005850	Congenital talipes calcaneovalgus	http://purl.obolibrary.org/obo/HP_0001884	Talipes calcaneovalgus		
http://purl.obolibrary.org/obo/HP_0040231	Abnormal onset of bleeding	http://purl.obolibrary.org/obo/HP_0001892	Abnormal bleeding		
http://purl.obolibrary.org/obo/HP_0005967	Mixed respiratory and metabolic acidosis	http://purl.obolibrary.org/obo/HP_0001942	Metabolic acidosis		
http://purl.obolibrary.org/obo/HP_0005976	Hyperkalemic metabolic acidosis	http://purl.obolibrary.org/obo/HP_0001942	Metabolic acidosis		
http://purl.obolibrary.org/obo/HP_0004910	Bicarbonate-wasting renal tubular acidosis	http://purl.obolibrary.org/obo/HP_0001947	Renal tubular acidosis		
http://purl.obolibrary.org/obo/HP_0005977	Hypochloremic metabolic alkalosis	http://purl.obolibrary.org/obo/HP_0001948	Alkalosis		
http://purl.obolibrary.org/obo/HP_0004909	Hypokalemic hypochloremic metabolic alkalosis	http://purl.obolibrary.org/obo/HP_0005977	Hypochloremic metabolic alkalosis		
http://purl.obolibrary.org/obo/HP_0040033	Aplasia/Hypoplasia of the fifth metatarsal bone	http://purl.obolibrary.org/obo/HP_0008089	Abnormality of the fifth metatarsal bone		
http://purl.obolibrary.org/obo/HP_0004861	Refractory macrocytic anemia	http://purl.obolibrary.org/obo/HP_0001972	Macrocytic anemia		
http://purl.obolibrary.org/obo/HP_0005532	Macrocytic dyserythropoietic anemia	http://purl.obolibrary.org/obo/HP_0001972	Macrocytic anemia		
http://purl.obolibrary.org/obo/HP_0004906	Hypernatremic dehydration	http://purl.obolibrary.org/obo/HP_0001986	Hypertonic dehydration		
http://purl.obolibrary.org/obo/HP_0008336	Complex organic aciduria	http://purl.obolibrary.org/obo/HP_0001992	Organic aciduria		
http://purl.obolibrary.org/obo/HP_0005461	Craniofacial disproportion	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		
http://purl.obolibrary.org/obo/HP_0100729	Large face	http://purl.obolibrary.org/obo/HP_0001999	Abnormal facial shape		
http://purl.obolibrary.org/obo/HP_0004385	Protracted diarrhea	http://purl.obolibrary.org/obo/HP_0002014	Diarrhea		
http://purl.obolibrary.org/obo/HP_0005240	Esophageal obstruction	http://purl.obolibrary.org/obo/HP_0004796	Gastrointestinal obstruction		
http://purl.obolibrary.org/obo/HP_0004403	Proximal esophageal atresia	http://purl.obolibrary.org/obo/HP_0002032	Esophageal atresia		
http://purl.obolibrary.org/obo/HP_0100743	Neoplasm of the rectum	http://purl.obolibrary.org/obo/HP_0100834	Neoplasm of the large intestine		
http://purl.obolibrary.org/obo/HP_0006918	Diffuse cerebral sclerosis	http://purl.obolibrary.org/obo/HP_0002060	Abnormal cerebral morphology		
http://purl.obolibrary.org/obo/HP_0007363	Aplasia/Hypoplasia of the pyramidal tract	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		
http://purl.obolibrary.org/obo/HP_0007153	Progressive extrapyramidal movement disorder	http://purl.obolibrary.org/obo/HP_0002071	Abnormality of extrapyramidal motor function		
http://purl.obolibrary.org/obo/HP_0007308	Extrapyramidal dyskinesia	http://purl.obolibrary.org/obo/HP_0100660	Dyskinesia		
http://purl.obolibrary.org/obo/HP_0007221	Progressive truncal ataxia	http://purl.obolibrary.org/obo/HP_0002078	Truncal ataxia		
http://purl.obolibrary.org/obo/HP_0006888	Meningoencephalocele	http://purl.obolibrary.org/obo/HP_0002084	Encephalocele		
http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature	http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the vasculature		
http://purl.obolibrary.org/obo/HP_0006531	Pleural lymphangiectasia	http://purl.obolibrary.org/obo/HP_0031842	Lymphangiectasis		
http://purl.obolibrary.org/obo/HP_0100527	Neoplasia of the pleura	http://purl.obolibrary.org/obo/HP_0100606	Neoplasm of the respiratory system		
http://purl.obolibrary.org/obo/HP_0005939	Multiple bilateral pneumothoraces	http://purl.obolibrary.org/obo/HP_0002107	Pneumothorax		
http://purl.obolibrary.org/obo/HP_0006522	Repeated pneumothoraces	http://purl.obolibrary.org/obo/HP_0002107	Pneumothorax		
http://purl.obolibrary.org/obo/HP_0007100	Progressive ventriculomegaly	http://purl.obolibrary.org/obo/HP_0002119	Ventriculomegaly		
http://purl.obolibrary.org/obo/HP_0100951	Enlarged fossa interpeduncularis	http://purl.obolibrary.org/obo/HP_0002119	Ventriculomegaly		
http://purl.obolibrary.org/obo/HP_0006799	Basal ganglia cysts	http://purl.obolibrary.org/obo/HP_0010576	Intracranial cystic lesion		
http://purl.obolibrary.org/obo/HP_0007146	Bilateral basal ganglia lesions	http://purl.obolibrary.org/obo/HP_0002134	Abnormal basal ganglia morphology		
http://purl.obolibrary.org/obo/HP_0007344	Atrophy/Degeneration involving the spinal cord	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		
http://purl.obolibrary.org/obo/HP_0008285	Transient hypophosphatemia	http://purl.obolibrary.org/obo/HP_0002148	Hypophosphatemia		
http://purl.obolibrary.org/obo/HP_0008288	Nonketotic hyperglycinemia	http://purl.obolibrary.org/obo/HP_0002154	Hyperglycinemia		
http://purl.obolibrary.org/obo/HP_0040140	Degeneration of the striatum	http://purl.obolibrary.org/obo/HP_0010994	Abnormal corpus striatum morphology		
http://purl.obolibrary.org/obo/HP_0004771	Premature graying of body hair	http://purl.obolibrary.org/obo/HP_0002216	Premature graying of hair		
http://purl.obolibrary.org/obo/HP_0004527	Large clumps of pigment irregularly distributed along hair shaft	http://purl.obolibrary.org/obo/HP_0002220	Melanin pigment aggregation in hair shafts		
http://purl.obolibrary.org/obo/HP_0004529	Atrophic, patchy alopecia	http://purl.obolibrary.org/obo/HP_0002232	Patchy alopecia		
http://purl.obolibrary.org/obo/HP_0005223	Duplicated colon	http://purl.obolibrary.org/obo/HP_0100668	Intestinal duplication		
http://purl.obolibrary.org/obo/HP_0004786	Jejunal diverticula	http://purl.obolibrary.org/obo/HP_0002256	Small bowel diverticula		
http://purl.obolibrary.org/obo/HP_0004799	Jejunoileal diverticula	http://purl.obolibrary.org/obo/HP_0002256	Small bowel diverticula		
http://purl.obolibrary.org/obo/HP_0004800	Duodenal diverticula	http://purl.obolibrary.org/obo/HP_0002256	Small bowel diverticula		
http://purl.obolibrary.org/obo/HP_0004499	Chronic rhinitis due to narrow nasal airway	http://purl.obolibrary.org/obo/HP_0002257	Chronic rhinitis		
http://purl.obolibrary.org/obo/HP_0007057	Poor hand-eye coordination	http://purl.obolibrary.org/obo/HP_0002311	Incoordination		
http://purl.obolibrary.org/obo/HP_0007199	Progressive spastic paraparesis	http://purl.obolibrary.org/obo/HP_0002313	Spastic paraparesis		
http://purl.obolibrary.org/obo/HP_0006962	Gait instability, worse in the dark	http://purl.obolibrary.org/obo/HP_0002317	Unsteady gait		
http://purl.obolibrary.org/obo/HP_0007001	Loss of Purkinje cells in the cerebellar vermis	http://purl.obolibrary.org/obo/HP_0002334	Abnormal cerebellar vermis morphology		
http://purl.obolibrary.org/obo/HP_0007065	Disorganization of the anterior cerebellar vermis	http://purl.obolibrary.org/obo/HP_0002334	Abnormal cerebellar vermis morphology		
http://purl.obolibrary.org/obo/HP_0006951	Retrocerebellar cyst	http://purl.obolibrary.org/obo/HP_0002350	Cerebellar cyst		
http://purl.obolibrary.org/obo/HP_0006859	Posterior leukoencephalopathy	http://purl.obolibrary.org/obo/HP_0002352	Leukoencephalopathy		
http://purl.obolibrary.org/obo/HP_0006943	Diffuse spongiform leukoencephalopathy	http://purl.obolibrary.org/obo/HP_0002352	Leukoencephalopathy		
http://purl.obolibrary.org/obo/HP_0006994	Diffuse leukoencephalopathy	http://purl.obolibrary.org/obo/HP_0002352	Leukoencephalopathy		
http://purl.obolibrary.org/obo/HP_0007311	Short stepped shuffling gait	http://purl.obolibrary.org/obo/HP_0002362	Shuffling gait		
http://purl.obolibrary.org/obo/HP_0007366	Atrophy/Degeneration affecting the brainstem	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		
http://purl.obolibrary.org/obo/HP_0007083	Hyperactive patellar reflex	http://purl.obolibrary.org/obo/HP_0007054	Proximal hyperreflexia		
http://purl.obolibrary.org/obo/HP_0005857	Cervical spina bifida	http://purl.obolibrary.org/obo/HP_0002414	Spina bifida		
http://purl.obolibrary.org/obo/HP_0006978	Dysmyelinating leukodystrophy	http://purl.obolibrary.org/obo/HP_0002415	Leukodystrophy		
http://purl.obolibrary.org/obo/HP_0007271	Occipital myelomeningocele	http://purl.obolibrary.org/obo/HP_0002436	Occipital meningocele		
http://purl.obolibrary.org/obo/HP_0007277	Paucity of anterior horn motor neurons	http://purl.obolibrary.org/obo/HP_0002450	Abnormal motor neuron morphology		
http://purl.obolibrary.org/obo/HP_0006961	Jerky head movements	http://purl.obolibrary.org/obo/HP_0002457	Abnormal head movements		
http://purl.obolibrary.org/obo/HP_0007111	Chronic hepatic encephalopathy	http://purl.obolibrary.org/obo/HP_0002480	Hepatic encephalopathy		
http://purl.obolibrary.org/obo/HP_0007365	Aplasia/Hypoplasia involving the corticospinal tracts	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		
http://purl.obolibrary.org/obo/HP_0008361	Corticospinal tract pallor	http://purl.obolibrary.org/obo/HP_0002492	Abnormal corticospinal tract morphology		
http://purl.obolibrary.org/obo/HP_0007299	Dysfunction of lateral corticospinal tracts	http://purl.obolibrary.org/obo/HP_0002493	Upper motor neuron dysfunction		
http://purl.obolibrary.org/obo/HP_0007042	Focal white matter lesions	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		
http://purl.obolibrary.org/obo/HP_0007052	Multifocal cerebral white matter abnormalities	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		
http://purl.obolibrary.org/obo/HP_0007204	Diffuse white matter abnormalities	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		
http://purl.obolibrary.org/obo/HP_0007341	Diffuse swelling of cerebral white matter	http://purl.obolibrary.org/obo/HP_0002500	Abnormal cerebral white matter morphology		
http://purl.obolibrary.org/obo/HP_0007346	Subcortical white matter calcifications	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		
http://purl.obolibrary.org/obo/HP_0006794	Loss of ability to walk in first decade	http://purl.obolibrary.org/obo/HP_0002505	Loss of ambulation		
http://purl.obolibrary.org/obo/HP_0008945	Loss of ability to walk in early childhood	http://purl.obolibrary.org/obo/HP_0002505	Loss of ambulation		
http://purl.obolibrary.org/obo/HP_0006895	Lower limb hypertonia	http://purl.obolibrary.org/obo/HP_0002509	Limb hypertonia		
http://purl.obolibrary.org/obo/HP_0007045	Midline brain calcifications	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		
http://purl.obolibrary.org/obo/HP_0007238	Nonarteriosclerotic cerebral calcification	http://purl.obolibrary.org/obo/HP_0002514	Cerebral calcification		
http://purl.obolibrary.org/obo/HP_0006790	Cerebral cortex with spongiform changes	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		
http://purl.obolibrary.org/obo/HP_0006891	Thick cerebral cortex	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		
http://purl.obolibrary.org/obo/HP_0007190	Neuronal loss in the cerebral cortex	http://purl.obolibrary.org/obo/HP_0002538	Abnormal cerebral cortex morphology		
http://purl.obolibrary.org/obo/HP_0006915	Inability to walk by childhood/adolescence	http://purl.obolibrary.org/obo/HP_0002540	Inability to walk		
http://purl.obolibrary.org/obo/HP_0005211	Midgut malrotation	http://purl.obolibrary.org/obo/HP_0002566	Intestinal malrotation		
http://purl.obolibrary.org/obo/HP_0005200	Retroperitoneal fibrosis	http://purl.obolibrary.org/obo/HP_0002585	Abnormal peritoneum morphology		
http://purl.obolibrary.org/obo/HP_0010676	Mechanical ileus	http://purl.obolibrary.org/obo/HP_0002595	Ileus		
http://purl.obolibrary.org/obo/HP_0008047	Abnormality of the vasculature of the eye	http://purl.obolibrary.org/obo/HP_0012372	Abnormal eye morphology		
http://purl.obolibrary.org/obo/HP_0025015	Abnormal vascular morphology	http://purl.obolibrary.org/obo/HP_0030680	Abnormal cardiovascular system morphology		
http://purl.obolibrary.org/obo/HP_0006566	Neonatal cholestatic liver disease	http://purl.obolibrary.org/obo/HP_0002611	Cholestatic liver disease		
http://purl.obolibrary.org/obo/HP_0004416	Precocious atherosclerosis	http://purl.obolibrary.org/obo/HP_0002621	Atherosclerosis		
http://purl.obolibrary.org/obo/HP_0004875	Neonatal inspiratory stridor	http://purl.obolibrary.org/obo/HP_0005348	Inspiratory stridor		
http://purl.obolibrary.org/obo/HP_0009103	Aplasia/Hypoplasia involving the pelvis	http://purl.obolibrary.org/obo/HP_0002644	Abnormal pelvic girdle bone morphology		
http://purl.obolibrary.org/obo/HP_0040163	Abnormal pelvis bone morphology	http://purl.obolibrary.org/obo/HP_0002644	Abnormal pelvic girdle bone morphology		
http://purl.obolibrary.org/obo/HP_0005716	Lethal skeletal dysplasia	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		
http://purl.obolibrary.org/obo/HP_0005775	Multiple skeletal anomalies	http://purl.obolibrary.org/obo/HP_0002652	Skeletal dysplasia		
http://purl.obolibrary.org/obo/HP_0040098	Basalioma of the outer ear	http://purl.obolibrary.org/obo/HP_0040095	Neoplasm of the outer ear		
http://purl.obolibrary.org/obo/HP_0006716	Hereditary nonpolyposis colorectal carcinoma	http://purl.obolibrary.org/obo/HP_0100834	Neoplasm of the large intestine		
http://purl.obolibrary.org/obo/HP_0005449	Bridged sella turcica	http://purl.obolibrary.org/obo/HP_0002681	Deformed sella turcica		
http://purl.obolibrary.org/obo/HP_0005463	Elongated sella turcica	http://purl.obolibrary.org/obo/HP_0002681	Deformed sella turcica		
http://purl.obolibrary.org/obo/HP_0005723	Shoe-shaped sella turcica	http://purl.obolibrary.org/obo/HP_0002681	Deformed sella turcica		
http://purl.obolibrary.org/obo/HP_0005478	Prominent frontal sinuses	http://purl.obolibrary.org/obo/HP_0002687	Abnormality of frontal sinus		
http://purl.obolibrary.org/obo/HP_0032251	Abnormal immune system morphology	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the immune system		
http://purl.obolibrary.org/obo/HP_0004889	Intermittent episodes of respiratory insufficiency due to muscle weakness	http://purl.obolibrary.org/obo/HP_0002747	Respiratory insufficiency due to muscle weakness		
http://purl.obolibrary.org/obo/HP_0004912	Hypophosphatemic rickets	http://purl.obolibrary.org/obo/HP_0002748	Rickets		
http://purl.obolibrary.org/obo/HP_0006463	Rickets of the lower limbs	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		
http://purl.obolibrary.org/obo/HP_0004619	Lumbar kyphoscoliosis	http://purl.obolibrary.org/obo/HP_0008454	Lumbar kyphosis		
http://purl.obolibrary.org/obo/HP_0008453	Congenital kyphoscoliosis	http://purl.obolibrary.org/obo/HP_0002751	Kyphoscoliosis		
http://purl.obolibrary.org/obo/HP_0004272	Cortical thinning of hand bones	http://purl.obolibrary.org/obo/HP_0005926	Abnormal hand cortical bone morphology		
http://purl.obolibrary.org/obo/HP_0004268	Osteoarthritis of the small joints of the hand	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0005086	Knee osteoarthritis	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		
http://purl.obolibrary.org/obo/HP_0008843	Hip osteoarthritis	http://purl.obolibrary.org/obo/HP_0002758	Osteoarthritis		
http://purl.obolibrary.org/obo/HP_0008178	Abnormal cartilage matrix	http://purl.obolibrary.org/obo/HP_0002763	Abnormal cartilage morphology		
http://purl.obolibrary.org/obo/HP_0100773	Cartilage destruction	http://purl.obolibrary.org/obo/HP_0002763	Abnormal cartilage morphology		
http://purl.obolibrary.org/obo/HP_0008755	Laryngotracheomalacia	http://purl.obolibrary.org/obo/HP_0002779	Tracheomalacia		
http://purl.obolibrary.org/obo/HP_0004881	Episodic hypoventilation	http://purl.obolibrary.org/obo/HP_0002791	Hypoventilation		
http://purl.obolibrary.org/obo/HP_0007110	Central hypoventilation	http://purl.obolibrary.org/obo/HP_0002791	Hypoventilation		
http://purl.obolibrary.org/obo/HP_0006520	Progressive pulmonary function impairment	http://purl.obolibrary.org/obo/HP_0002795	Abnormal respiratory system physiology		
http://purl.obolibrary.org/obo/HP_0009139	Osteolysis involving bones of the lower limbs	http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology		
http://purl.obolibrary.org/obo/HP_0045039	Osteolysis involving bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0040070	Abnormal upper limb bone morphology		
http://purl.obolibrary.org/obo/HP_0005745	Congenital foot contractures	http://purl.obolibrary.org/obo/HP_0005750	Lower-limb joint contracture		
http://purl.obolibrary.org/obo/HP_0005853	Congenital foot contraction deformities	http://purl.obolibrary.org/obo/HP_0002803	Congenital contracture		
http://purl.obolibrary.org/obo/HP_0040069	Abnormal lower limb bone morphology	http://purl.obolibrary.org/obo/HP_0002814	Abnormality of the lower limb		
http://purl.obolibrary.org/obo/HP_0040070	Abnormal upper limb bone morphology	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		
http://purl.obolibrary.org/obo/HP_0009142	Duplication of bones involving the upper extremities	http://purl.obolibrary.org/obo/HP_0002817	Abnormality of the upper limb		
http://purl.obolibrary.org/obo/HP_0003976	Constricted radius	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		
http://purl.obolibrary.org/obo/HP_0003977	Deformed radius	http://purl.obolibrary.org/obo/HP_0003959	Deformed forearm bones		
http://purl.obolibrary.org/obo/HP_0003978	Fractured radius	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		
http://purl.obolibrary.org/obo/HP_0003979	Lytic defects of the radius	http://purl.obolibrary.org/obo/HP_0003963	Lytic defects of the forearm bones		
http://purl.obolibrary.org/obo/HP_0003980	Pseudarthrosis of the radius	http://purl.obolibrary.org/obo/HP_0003965	Pseudarthrosis of the forearm bones		
http://purl.obolibrary.org/obo/HP_0003986	Exostoses of the radius	http://purl.obolibrary.org/obo/HP_0003960	Exostoses of the forearm bones		
http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology	http://purl.obolibrary.org/obo/HP_0003839	Abnormal upper limb epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0045008	Abnormal shape of the radius	http://purl.obolibrary.org/obo/HP_0002818	Abnormal morphology of the radius		
http://purl.obolibrary.org/obo/HP_0040061	Osteosclerosis of the radius	http://purl.obolibrary.org/obo/HP_0003967	Sclerotic forearm bones		
http://purl.obolibrary.org/obo/HP_0006408	Distal tapering femur	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		
http://purl.obolibrary.org/obo/HP_0006432	Trapezoidal distal femoral condyles	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		
http://purl.obolibrary.org/obo/HP_0006437	Disproportionate prominence of the femoral medial condyle	http://purl.obolibrary.org/obo/HP_0002823	Abnormal femur morphology		
http://purl.obolibrary.org/obo/HP_0100009	Intracranial meningioma	http://purl.obolibrary.org/obo/HP_0002858	Meningioma		
http://purl.obolibrary.org/obo/HP_0100010	Spinal meningioma	http://purl.obolibrary.org/obo/HP_0002858	Meningioma		
http://purl.obolibrary.org/obo/HP_0006743	Embryonal rhabdomyosarcoma	http://purl.obolibrary.org/obo/HP_0002898	Embryonal neoplasm		
http://purl.obolibrary.org/obo/HP_0006779	Alveolar rhabdomyosarcoma	http://purl.obolibrary.org/obo/HP_0002859	Rhabdomyosarcoma		
http://purl.obolibrary.org/obo/HP_0006715	Glomus tympanicum paraganglioma	http://purl.obolibrary.org/obo/HP_0002864	Paraganglioma of head and neck		
http://purl.obolibrary.org/obo/HP_0007129	Cerebellar medulloblastoma	http://purl.obolibrary.org/obo/HP_0002885	Medulloblastoma		
http://purl.obolibrary.org/obo/HP_0011779	Anaplastic thyroid carcinoma	http://purl.obolibrary.org/obo/HP_0002890	Thyroid carcinoma		
http://purl.obolibrary.org/obo/HP_0040198	Non-medullary thyroid carcinoma	http://purl.obolibrary.org/obo/HP_0002890	Thyroid carcinoma		
http://purl.obolibrary.org/obo/HP_0011758	Pituitary acidophilic stem cell adenoma	http://purl.obolibrary.org/obo/HP_0002893	Pituitary adenoma		
http://purl.obolibrary.org/obo/HP_0008176	Neonatal unconjugated hyperbilirubinemia	http://purl.obolibrary.org/obo/HP_0002904	Hyperbilirubinemia		
http://purl.obolibrary.org/obo/HP_0200148	Abnormal liver function tests during pregnancy	http://purl.obolibrary.org/obo/HP_0002910	Elevated circulating hepatic transaminase concentration		
http://purl.obolibrary.org/obo/HP_0008263	Thyroid defect in oxidation and organification of iodide	http://purl.obolibrary.org/obo/HP_0002926	Abnormality of thyroid physiology		
http://purl.obolibrary.org/obo/HP_0005659	Thoracic kyphoscoliosis	http://purl.obolibrary.org/obo/HP_0002943	Thoracic scoliosis		
http://purl.obolibrary.org/obo/HP_0004626	Lumbar scoliosis	http://purl.obolibrary.org/obo/HP_0002944	Thoracolumbar scoliosis		
http://purl.obolibrary.org/obo/HP_0008416	Six lumbar vertebrae	http://purl.obolibrary.org/obo/HP_0002946	Supernumerary vertebrae		
http://purl.obolibrary.org/obo/HP_0004557	Anterior vertebral fusion	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		
http://purl.obolibrary.org/obo/HP_0005640	Abnormal vertebral segmentation and fusion	http://purl.obolibrary.org/obo/HP_0002948	Vertebral fusion		
http://purl.obolibrary.org/obo/HP_0004575	Fusion of midcervical facet joints	http://purl.obolibrary.org/obo/HP_0002949	Fused cervical vertebrae		
http://purl.obolibrary.org/obo/HP_0008449	Progressive cervical vertebral spine fusion	http://purl.obolibrary.org/obo/HP_0002949	Fused cervical vertebrae		
http://purl.obolibrary.org/obo/HP_0005632	Absent forearm	http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology		
http://purl.obolibrary.org/obo/HP_0006368	Forearm reduction defects	http://purl.obolibrary.org/obo/HP_0002973	Abnormal forearm morphology		
http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology	http://purl.obolibrary.org/obo/HP_0040070	Abnormal upper limb bone morphology		
http://purl.obolibrary.org/obo/HP_0006894	Hypoplastic olfactory lobes	http://purl.obolibrary.org/obo/HP_0025057	Abnormal olfactory lobe morphology		
http://purl.obolibrary.org/obo/HP_0007036	Hypoplasia of olfactory tract	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		
http://purl.obolibrary.org/obo/HP_0011000	Aplasia/Hypoplasia of the optic tract	http://purl.obolibrary.org/obo/HP_0002977	Aplasia/Hypoplasia involving the central nervous system		
http://purl.obolibrary.org/obo/HP_0005928	Synostosis involving the fibula	http://purl.obolibrary.org/obo/HP_0009138	Synostosis involving bones of the lower limbs		
http://purl.obolibrary.org/obo/HP_0100535	Tibiofibular diastasis	http://purl.obolibrary.org/obo/HP_0002992	Abnormal tibia morphology		
http://purl.obolibrary.org/obo/HP_0005929	Synostosis involving the tibia	http://purl.obolibrary.org/obo/HP_0009138	Synostosis involving bones of the lower limbs		
http://purl.obolibrary.org/obo/HP_0006491	Abnormal tibial metaphysis morphology	http://purl.obolibrary.org/obo/HP_0006490	Abnormal lower-limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0006508	Abnormality of tibial epiphyses	http://purl.obolibrary.org/obo/HP_0006500	Abnormal lower limb epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0006376	Limited elbow flexion	http://purl.obolibrary.org/obo/HP_0002996	Limited elbow movement		
http://purl.obolibrary.org/obo/HP_0006742	Congenital neuroblastoma	http://purl.obolibrary.org/obo/HP_0003006	Neuroblastoma		
http://purl.obolibrary.org/obo/HP_0006747	Ganglioneuroblastoma	http://purl.obolibrary.org/obo/HP_0003006	Neuroblastoma		
http://purl.obolibrary.org/obo/HP_0006768	Localized neuroblastoma	http://purl.obolibrary.org/obo/HP_0003006	Neuroblastoma		
http://purl.obolibrary.org/obo/HP_0040172	Abnormality of occipitofrontalis muscle	http://purl.obolibrary.org/obo/HP_0003011	Abnormality of the musculature		
http://purl.obolibrary.org/obo/HP_0005028	Widened proximal tibial metaphyses	http://purl.obolibrary.org/obo/HP_0003016	Metaphyseal widening		
http://purl.obolibrary.org/obo/HP_0005042	Irregular, rachitic-like metaphyses	http://purl.obolibrary.org/obo/HP_0003025	Metaphyseal irregularity		
http://purl.obolibrary.org/obo/HP_0003973	Wide radioulnar joints	http://purl.obolibrary.org/obo/HP_0003059	Abnormality of the radioulnar joints		
http://purl.obolibrary.org/obo/HP_0006247	Enlarged interphalangeal joints	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0005195	Polyarticular arthropathy	http://purl.obolibrary.org/obo/HP_0003040	Arthropathy		
http://purl.obolibrary.org/obo/HP_0005021	Bilateral elbow dislocations	http://purl.obolibrary.org/obo/HP_0003042	Elbow dislocation		
http://purl.obolibrary.org/obo/HP_0006659	Internally rotated shoulders	http://purl.obolibrary.org/obo/HP_0003043	Abnormal shoulder morphology		
http://purl.obolibrary.org/obo/HP_0006378	Osteolysis of patellae	http://purl.obolibrary.org/obo/HP_0009139	Osteolysis involving bones of the lower limbs		
http://purl.obolibrary.org/obo/HP_0006397	Lateral displacement of patellae	http://purl.obolibrary.org/obo/HP_0003045	Abnormal patella morphology		
http://purl.obolibrary.org/obo/HP_0006446	Dysplastic patella	http://purl.obolibrary.org/obo/HP_0003330	Abnormal bone structure		
http://purl.obolibrary.org/obo/HP_0006172	Flattened, squared-off epiphyses of tubular bones	http://purl.obolibrary.org/obo/HP_0003071	Flattened epiphysis		
http://purl.obolibrary.org/obo/HP_0005829	Maldevelopment of radioulnar joint	http://purl.obolibrary.org/obo/HP_0003059	Abnormality of the radioulnar joints		
http://purl.obolibrary.org/obo/HP_0004002	Flattened radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0005715	Flattened knee epiphyses	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		
http://purl.obolibrary.org/obo/HP_0008279	Transient hyperlipidemia	http://purl.obolibrary.org/obo/HP_0003077	Hyperlipidemia		
http://purl.obolibrary.org/obo/HP_0040062	Slender radius	http://purl.obolibrary.org/obo/HP_0045008	Abnormal shape of the radius		
http://purl.obolibrary.org/obo/HP_0040129	Abnormal nerve conduction velocity	http://purl.obolibrary.org/obo/HP_0003134	Abnormality of peripheral nerve conduction		
http://purl.obolibrary.org/obo/HP_0008833	Irregular acetabular roof	http://purl.obolibrary.org/obo/HP_0003170	Abnormal acetabulum morphology		
http://purl.obolibrary.org/obo/HP_0008978	Necrotizing myopathy	http://purl.obolibrary.org/obo/HP_0003198	Myopathy		
http://purl.obolibrary.org/obo/HP_0008180	Mildly elevated creatine kinase	http://purl.obolibrary.org/obo/HP_0003236	Elevated circulating creatine kinase activity		
http://purl.obolibrary.org/obo/HP_0008331	Elevated creatine kinase after exercise	http://purl.obolibrary.org/obo/HP_0003236	Elevated circulating creatine kinase activity		
http://purl.obolibrary.org/obo/HP_0008265	Mitochondrial lysine transport defect	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		
http://purl.obolibrary.org/obo/HP_0008306	Abnormal iron deposition in mitochondria	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		
http://purl.obolibrary.org/obo/HP_0100950	Decreased 3-hydroxyacyl-CoA dehydrogenase level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		
http://purl.obolibrary.org/obo/HP_0200125	Mitochondrial respiratory chain defects	http://purl.obolibrary.org/obo/HP_0003287	Abnormality of mitochondrial metabolism		
http://purl.obolibrary.org/obo/HP_0008488	Anterior rounding of vertebral bodies	http://purl.obolibrary.org/obo/HP_0003300	Ovoid vertebral bodies		
http://purl.obolibrary.org/obo/HP_0004594	Hump-shaped mound of bone in central and posterior portions of vertebral endplate	http://purl.obolibrary.org/obo/HP_0003301	Irregular vertebral endplates		
http://purl.obolibrary.org/obo/HP_0008476	Irregular sclerotic endplates	http://purl.obolibrary.org/obo/HP_0003301	Irregular vertebral endplates		
http://purl.obolibrary.org/obo/HP_0004582	Irregularity of vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0004591	Disc-like vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0004609	Patchy distortion of vertebrae	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0004611	Anterior concavity of thoracic vertebrae	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0004618	Sandwich appearance of vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0004634	Cuboid-shaped vertebral bodies	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0008437	Bifid thoracic vertebrae	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0008516	Abnormality of the vertebral spinous processes	http://purl.obolibrary.org/obo/HP_0003312	Abnormal vertebral body morphology		
http://purl.obolibrary.org/obo/HP_0004637	Decreased cervical spine mobility	http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine		
http://purl.obolibrary.org/obo/HP_0005878	Enlarged sagittal diameter of the cervical canal	http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine		
http://purl.obolibrary.org/obo/HP_0008483	Cervical vertebral bodies with decreased anteroposterior diameter	http://purl.obolibrary.org/obo/HP_0003319	Abnormality of the cervical spine		
http://purl.obolibrary.org/obo/HP_0004020	Irregular ossification of the radial metaphysis	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0005841	Calcific stippling of infantile cartilaginous skeleton	http://purl.obolibrary.org/obo/HP_0003336	Abnormal enchondral ossification		
http://purl.obolibrary.org/obo/HP_0009107	Abnormal ossification involving the femoral head and neck	http://purl.obolibrary.org/obo/HP_0003366	Abnormal femoral neck/head morphology		
http://purl.obolibrary.org/obo/HP_0009108	Aplasia/Hypoplasia involving the femoral head and neck	http://purl.obolibrary.org/obo/HP_0009103	Aplasia/Hypoplasia involving the pelvis		
http://purl.obolibrary.org/obo/HP_0007249	Decreased number of small peripheral myelinated nerve fibers	http://purl.obolibrary.org/obo/HP_0003380	Decreased number of peripheral myelinated nerve fibers		
http://purl.obolibrary.org/obo/HP_0005678	Anterior atlanto-occipital dislocation	http://purl.obolibrary.org/obo/HP_0003414	Atlantoaxial dislocation		
http://purl.obolibrary.org/obo/HP_0008490	Sacral segmentation defect	http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology		
http://purl.obolibrary.org/obo/HP_0004589	Dysplasia of second lumbar vertebra	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		
http://purl.obolibrary.org/obo/HP_0005877	Multiple small vertebral fractures	http://purl.obolibrary.org/obo/HP_0003468	Abnormal vertebral morphology		
http://purl.obolibrary.org/obo/HP_0008515	Aplasia/Hypoplasia of the vertebrae	http://purl.obolibrary.org/obo/HP_0008518	Aplasia/Hypoplasia involving the vertebral column		
http://purl.obolibrary.org/obo/HP_0009056	Loss of subcutaneous adipose tissue from upper limbs	http://purl.obolibrary.org/obo/HP_0003635	Loss of subcutaneous adipose tissue in limbs		
http://purl.obolibrary.org/obo/HP_0004818	Paroxysmal nocturnal hemoglobinuria	http://purl.obolibrary.org/obo/HP_0003641	Hemoglobinuria		
http://purl.obolibrary.org/obo/HP_0005320	Lack of facial subcutaneous fat	http://purl.obolibrary.org/obo/HP_0003717	Minimal subcutaneous fat		
http://purl.obolibrary.org/obo/HP_0009069	Lethal infantile mitochondrial myopathy	http://purl.obolibrary.org/obo/HP_0003737	Mitochondrial myopathy		
http://purl.obolibrary.org/obo/HP_0008083	2nd-5th toe middle phalangeal hypoplasia	http://purl.obolibrary.org/obo/HP_0003795	Short middle phalanx of toe		
http://purl.obolibrary.org/obo/HP_0004037	Abnormal ulnar epiphysis morphology	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		
http://purl.obolibrary.org/obo/HP_0004016	Cupped radial metaphyses	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004021	Lytic defects of radial metaphysis	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004022	Sclerotic radial metaphysis with longitudinal striations	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004046	Spurred ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0005687	Deformed humeral heads	http://purl.obolibrary.org/obo/HP_0003871	Deformed humerus		
http://purl.obolibrary.org/obo/HP_0006362	Varus deformity of humeral neck	http://purl.obolibrary.org/obo/HP_0003887	Abnormal humeral head morphology		
http://purl.obolibrary.org/obo/HP_0004997	Multicentric ossification of proximal humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003897	Irregular ossification of the humeral epiphyses		
http://purl.obolibrary.org/obo/HP_0008838	Stippled calcification proximal humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003901	Stippled calcification of the humeral epiphyses		
http://purl.obolibrary.org/obo/HP_0005825	Mixed sclerosis of humeral metaphyses	http://purl.obolibrary.org/obo/HP_0003918	Sclerotic humeral metaphysis		
http://purl.obolibrary.org/obo/HP_0003996	Flattened radial head	http://purl.obolibrary.org/obo/HP_0003995	Abnormality of the radial head		
http://purl.obolibrary.org/obo/HP_0003997	Hypoplastic radial head	http://purl.obolibrary.org/obo/HP_0003995	Abnormality of the radial head		
http://purl.obolibrary.org/obo/HP_0004260	Large hamate bone	http://purl.obolibrary.org/obo/HP_0004237	Large carpal bones		
http://purl.obolibrary.org/obo/HP_0004263	Large capitate bone	http://purl.obolibrary.org/obo/HP_0004237	Large carpal bones		
http://purl.obolibrary.org/obo/HP_0006563	Malformation of the hepatic ductal plate	http://purl.obolibrary.org/obo/HP_0004297	Abnormality of the biliary system		
http://purl.obolibrary.org/obo/HP_0100296	Perifascicular muscle fiber atrophy	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		
http://purl.obolibrary.org/obo/HP_0100298	Motheaten muscle fibers	http://purl.obolibrary.org/obo/HP_0004303	Abnormal muscle fiber morphology		
http://purl.obolibrary.org/obo/HP_0007710	Peripheral vitreous opacities	http://purl.obolibrary.org/obo/HP_0004327	Abnormal vitreous humor morphology		
http://purl.obolibrary.org/obo/HP_0030601	Abnormal posterior segment imaging	http://purl.obolibrary.org/obo/HP_0004329	Abnormal posterior eye segment morphology		
http://purl.obolibrary.org/obo/HP_0007488	Diffuse skin atrophy	http://purl.obolibrary.org/obo/HP_0004334	Dermal atrophy		
http://purl.obolibrary.org/obo/HP_0005523	Lymphoproliferative disorder	http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm		
http://purl.obolibrary.org/obo/HP_0006782	Malignant eosinophil proliferation	http://purl.obolibrary.org/obo/HP_0004377	Hematological neoplasm		
http://purl.obolibrary.org/obo/HP_0004405	Prominent nipples	http://purl.obolibrary.org/obo/HP_0004404	Abnormal nipple morphology		
http://purl.obolibrary.org/obo/HP_0005428	Severe recurrent varicella	http://purl.obolibrary.org/obo/HP_0004429	Recurrent viral infections		
http://purl.obolibrary.org/obo/HP_0005327	Loss of facial expression	http://purl.obolibrary.org/obo/HP_0004673	Decreased facial expression		
http://purl.obolibrary.org/obo/HP_0005329	Fixed facial expression	http://purl.obolibrary.org/obo/HP_0004673	Decreased facial expression		
http://purl.obolibrary.org/obo/HP_0100784	Peripheral arteriovenous fistula	http://purl.obolibrary.org/obo/HP_0004947	Arteriovenous fistula		
http://purl.obolibrary.org/obo/HP_0040057	Abnormal nasal hair morphology	http://purl.obolibrary.org/obo/HP_0005105	Abnormal nasal morphology		
http://purl.obolibrary.org/obo/HP_0004603	Hyperconvex vertebral body endplates	http://purl.obolibrary.org/obo/HP_0005106	Abnormality of the vertebral endplates		
http://purl.obolibrary.org/obo/HP_0005765	Sacral meningocele	http://purl.obolibrary.org/obo/HP_0005107	Abnormal sacrum morphology		
http://purl.obolibrary.org/obo/HP_0005234	Neonatal intestinal obstruction	http://purl.obolibrary.org/obo/HP_0005214	Intestinal obstruction		
http://purl.obolibrary.org/obo/HP_0005250	High intestinal obstruction	http://purl.obolibrary.org/obo/HP_0005214	Intestinal obstruction		
http://purl.obolibrary.org/obo/HP_0005254	Unilateral chest hypoplasia	http://purl.obolibrary.org/obo/HP_0005257	Thoracic hypoplasia		
http://purl.obolibrary.org/obo/HP_0006647	Congenital microthorax	http://purl.obolibrary.org/obo/HP_0005257	Thoracic hypoplasia		
http://purl.obolibrary.org/obo/HP_0005954	Pulmonary capillary hemangiomatosis	http://purl.obolibrary.org/obo/HP_0007461	Hemangiomatosis		
http://purl.obolibrary.org/obo/HP_0005335	Sleepy facial expression	http://purl.obolibrary.org/obo/HP_0005324	Disturbance of facial expression		
http://purl.obolibrary.org/obo/HP_0100552	Neoplasm of the tracheobronchial system	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		
http://purl.obolibrary.org/obo/HP_0006366	Adductor longus contractures	http://purl.obolibrary.org/obo/HP_0005750	Lower-limb joint contracture		
http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology	http://purl.obolibrary.org/obo/HP_0005924	Abnormal hand epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0006012	Widened metacarpal shaft	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0006086	Thin metacarpal cortices	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0006166	Tubular metacarpal bones	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0006232	Expanded metacarpals with widened medullary cavities	http://purl.obolibrary.org/obo/HP_0005916	Abnormal metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0004275	Duplication of hand bones	http://purl.obolibrary.org/obo/HP_0009142	Duplication of bones involving the upper extremities		
http://purl.obolibrary.org/obo/HP_0004277	Fractured hand bones	http://purl.obolibrary.org/obo/HP_0020110	Bone fracture		
http://purl.obolibrary.org/obo/HP_0004284	Notched hand bones	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		
http://purl.obolibrary.org/obo/HP_0004285	Overmodelled hand bones	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		
http://purl.obolibrary.org/obo/HP_0004287	Pointed hand bones	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		
http://purl.obolibrary.org/obo/HP_0004292	Undermodelled hand bones	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		
http://purl.obolibrary.org/obo/HP_0005923	Abnormal hand metaphysis morphology	http://purl.obolibrary.org/obo/HP_0009809	Abnormal upper limb metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0005925	Abnormal hand diaphysis morphology	http://purl.obolibrary.org/obo/HP_0009808	Anomaly of the upper limb diaphyses		
http://purl.obolibrary.org/obo/HP_0006228	Valgus hand deformity	http://purl.obolibrary.org/obo/HP_0005922	Abnormal hand morphology		
http://purl.obolibrary.org/obo/HP_0009699	Osteolytic defects of the hand bones	http://purl.obolibrary.org/obo/HP_0045039	Osteolysis involving bones of the upper limbs		
http://purl.obolibrary.org/obo/HP_0004990	Epiphyseal streaking	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010577	Absent epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010578	Bracket epiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010584	Pseudoepiphyses	http://purl.obolibrary.org/obo/HP_0005930	Abnormal epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0005997	Neck joint contracture	http://purl.obolibrary.org/obo/HP_0034392	Joint contracture		
http://purl.obolibrary.org/obo/HP_0004253	Absent trapezium	http://purl.obolibrary.org/obo/HP_0004252	Abnormal trapezium morphology		
http://purl.obolibrary.org/obo/HP_0006176	Two carpal ossification centers present at birth	http://purl.obolibrary.org/obo/HP_0006257	Abnormality of carpal bone ossification		
http://purl.obolibrary.org/obo/HP_0009164	Abnormal calcification of the carpal bones	http://purl.obolibrary.org/obo/HP_0010766	Ectopic calcification		
http://purl.obolibrary.org/obo/HP_0045001	Abnormal ossification of the trapezium	http://purl.obolibrary.org/obo/HP_0004252	Abnormal trapezium morphology		
http://purl.obolibrary.org/obo/HP_0045004	Abnormal ossification of the trapezoid bone	http://purl.obolibrary.org/obo/HP_0004256	Abnormal trapezoid bone morphology		
http://purl.obolibrary.org/obo/HP_0006308	Atrophy of alveolar ridges	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		
http://purl.obolibrary.org/obo/HP_0009084	Midline notch of upper alveolar ridge	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		
http://purl.obolibrary.org/obo/HP_0009092	Progressive alveolar ridge hypertrophy	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		
http://purl.obolibrary.org/obo/HP_0009094	Cleft lower alveolar ridge	http://purl.obolibrary.org/obo/HP_0006477	Abnormal alveolar ridge morphology		
http://purl.obolibrary.org/obo/HP_0040079	Irregular dentition	http://purl.obolibrary.org/obo/HP_0006482	Abnormal dental morphology		
http://purl.obolibrary.org/obo/HP_0200153	Agenesis of lateral incisor	http://purl.obolibrary.org/obo/HP_0006485	Agenesis of incisor		
http://purl.obolibrary.org/obo/HP_0200160	Agenesis of maxillary incisor	http://purl.obolibrary.org/obo/HP_0006485	Agenesis of incisor		
http://purl.obolibrary.org/obo/HP_0011072	Rootless teeth	http://purl.obolibrary.org/obo/HP_0006486	Abnormal dental root morphology		
http://purl.obolibrary.org/obo/HP_0006417	Wide femoral metaphysis	http://purl.obolibrary.org/obo/HP_0006489	Abnormal femoral metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0010173	Aplasia/Hypoplasia of the phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0005292	Intimal thickening in the coronary arteries	http://purl.obolibrary.org/obo/HP_0006704	Abnormal coronary artery morphology		
http://purl.obolibrary.org/obo/HP_0006557	Polycystic liver disease	http://purl.obolibrary.org/obo/HP_0006706	Cystic liver disease		
http://purl.obolibrary.org/obo/HP_0006574	Hepatic arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0100026	Arteriovenous malformation		
http://purl.obolibrary.org/obo/HP_0006576	Hepatic vascular malformations	http://purl.obolibrary.org/obo/HP_0006707	Abnormality of the hepatic vasculature		
http://purl.obolibrary.org/obo/HP_0007063	Aplasia of the inferior half of the cerebellar vermis	http://purl.obolibrary.org/obo/HP_0006817	Aplasia/Hypoplasia of the cerebellar vermis		
http://purl.obolibrary.org/obo/HP_0007268	Aprosencephaly	http://purl.obolibrary.org/obo/HP_0007364	Aplasia/Hypoplasia of the cerebrum		
http://purl.obolibrary.org/obo/HP_0007009	Central nervous system degeneration	http://purl.obolibrary.org/obo/HP_0007367	Atrophy/Degeneration affecting the central nervous system		
http://purl.obolibrary.org/obo/HP_0006964	Cerebral cortical neurodegeneration	http://purl.obolibrary.org/obo/HP_0007369	Atrophy/Degeneration affecting the cerebrum		
http://purl.obolibrary.org/obo/HP_0007117	Corticospinal tract atrophy	http://purl.obolibrary.org/obo/HP_0007372	Atrophy/Degeneration involving the corticospinal tracts		
http://purl.obolibrary.org/obo/HP_0007354	Amyotrophic lateral sclerosis	http://purl.obolibrary.org/obo/HP_0007373	Motor neuron atrophy		
http://purl.obolibrary.org/obo/HP_0007104	Prolonged somatosensory evoked potentials	http://purl.obolibrary.org/obo/HP_0007377	Abnormality of somatosensory evoked potentials		
http://purl.obolibrary.org/obo/HP_0100290	Abnormality of peripheral somatosensory evoked potentials	http://purl.obolibrary.org/obo/HP_0007377	Abnormality of somatosensory evoked potentials		
http://purl.obolibrary.org/obo/HP_0006719	Benign gastrointestinal tract tumors	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		
http://purl.obolibrary.org/obo/HP_0006723	Intestinal carcinoid	http://purl.obolibrary.org/obo/HP_0100570	Carcinoid tumor		
http://purl.obolibrary.org/obo/HP_0100723	Gastrointestinal stroma tumor	http://purl.obolibrary.org/obo/HP_0007378	Neoplasm of the gastrointestinal tract		
http://purl.obolibrary.org/obo/HP_0005585	Spotty hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0007450	Increased groin pigmentation with raindrop depigmentation	http://purl.obolibrary.org/obo/HP_0009123	Mixed hypo- and hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0007456	Progressive reticulate hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0007521	Irregular hyperpigmentation of back	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0007546	Linear hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0007572	Hyperpigmented streaks	http://purl.obolibrary.org/obo/HP_0007400	Irregular hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0100816	Lip hyperpigmentation	http://purl.obolibrary.org/obo/HP_0032453	Abnormal lip pigmentation		
http://purl.obolibrary.org/obo/HP_0007455	Adermatoglyphia	http://purl.obolibrary.org/obo/HP_0007477	Abnormal dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0100888	Interdigital loops	http://purl.obolibrary.org/obo/HP_0007477	Abnormal dermatoglyphics		
http://purl.obolibrary.org/obo/HP_0008509	Aged leonine appearance	http://purl.obolibrary.org/obo/HP_0007495	Prematurely aged appearance		
http://purl.obolibrary.org/obo/HP_0007986	Increased retinal vascularity	http://purl.obolibrary.org/obo/HP_0008046	Abnormal retinal vascular morphology		
http://purl.obolibrary.org/obo/HP_0007873	Abnormally prominent line of Schwalbe	http://purl.obolibrary.org/obo/HP_0008048	Abnormal line of Schwalbe morphology		
http://purl.obolibrary.org/obo/HP_0007383	Congenital localized absence of skin	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		
http://purl.obolibrary.org/obo/HP_0007398	Asymmetric, linear skin defects	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		
http://purl.obolibrary.org/obo/HP_0007411	Hypoplastic-absent sebaceous glands	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		
http://purl.obolibrary.org/obo/HP_0007510	Focal dermal aplasia/hypoplasia	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		
http://purl.obolibrary.org/obo/HP_0007515	Hypoplastic pilosebaceous units	http://purl.obolibrary.org/obo/HP_0008065	Aplasia/Hypoplasia of the skin		
http://purl.obolibrary.org/obo/HP_0007392	Excessive wrinkled skin	http://purl.obolibrary.org/obo/HP_0100678	Premature skin wrinkling		
http://purl.obolibrary.org/obo/HP_0007522	Increased number of skin folds	http://purl.obolibrary.org/obo/HP_0008067	Abnormally lax or hyperextensible skin		
http://purl.obolibrary.org/obo/HP_0006769	Myxoid subcutaneous tumors	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		
http://purl.obolibrary.org/obo/HP_0007606	Multiple cutaneous malignancies	http://purl.obolibrary.org/obo/HP_0008069	Neoplasm of the skin		
http://purl.obolibrary.org/obo/HP_0008117	Shortening of the talar neck	http://purl.obolibrary.org/obo/HP_0008365	Abnormal talus morphology		
http://purl.obolibrary.org/obo/HP_0034677	Ankle contracture	http://purl.obolibrary.org/obo/HP_0034673	Abnormal ankle morphology		
http://purl.obolibrary.org/obo/HP_0008193	Primary gonadal insufficiency	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		
http://purl.obolibrary.org/obo/HP_0008197	Absence of pubertal development	http://purl.obolibrary.org/obo/HP_0008373	Puberty and gonadal disorders		
http://purl.obolibrary.org/obo/HP_0008393	Congenital curved nail of fourth toe	http://purl.obolibrary.org/obo/HP_0008388	Abnormal toenail morphology		
http://purl.obolibrary.org/obo/HP_0008460	Hypoplastic spinal processes	http://purl.obolibrary.org/obo/HP_0008518	Aplasia/Hypoplasia involving the vertebral column		
http://purl.obolibrary.org/obo/HP_0200111	Absent stapes head	http://purl.obolibrary.org/obo/HP_0008628	Abnormal stapes morphology		
http://purl.obolibrary.org/obo/HP_0008687	Hypoplasia of the prostate	http://purl.obolibrary.org/obo/HP_0008775	Abnormal prostate morphology		
http://purl.obolibrary.org/obo/HP_0008742	Prominent prostate median bar	http://purl.obolibrary.org/obo/HP_0008775	Abnormal prostate morphology		
http://purl.obolibrary.org/obo/HP_0100787	Prostate neoplasm	http://purl.obolibrary.org/obo/HP_0033019	Male reproductive system neoplasm		
http://purl.obolibrary.org/obo/HP_0005026	Mesomelic/rhizomelic limb shortening	http://purl.obolibrary.org/obo/HP_0008905	Rhizomelia		
http://purl.obolibrary.org/obo/HP_0005069	Rhizo-meso-acromelic limb shortening	http://purl.obolibrary.org/obo/HP_0008905	Rhizomelia		
http://purl.obolibrary.org/obo/HP_0004058	Hand monodactyly	http://purl.obolibrary.org/obo/HP_0009380	Finger aplasia		
http://purl.obolibrary.org/obo/HP_0006210	Postaxial oligodactyly	http://purl.obolibrary.org/obo/HP_0009380	Finger aplasia		
http://purl.obolibrary.org/obo/HP_0006230	Unilateral oligodactyly	http://purl.obolibrary.org/obo/HP_0009380	Finger aplasia		
http://purl.obolibrary.org/obo/HP_0009881	Aplasia of distal finger phalanx	http://purl.obolibrary.org/obo/HP_0009835	Aplasia/Hypoplasia of the distal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010242	Aplasia of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009851	Aplasia/Hypoplasia of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0040020	Radial deviation of the 5th finger	http://purl.obolibrary.org/obo/HP_0009179	Deviation of the 5th finger		
http://purl.obolibrary.org/obo/HP_0009485	Radial deviation of the hand or of fingers of the hand	http://purl.obolibrary.org/obo/HP_0009484	Deviation of the hand or of fingers of the hand		
http://purl.obolibrary.org/obo/HP_0040023	Clinodactyly of the thumb	http://purl.obolibrary.org/obo/HP_0040019	Finger clinodactyly		
http://purl.obolibrary.org/obo/HP_0005688	Dysplastic distal thumb phalanges with a central hole	http://purl.obolibrary.org/obo/HP_0009617	Abnormality of the distal phalanx of the thumb		
http://purl.obolibrary.org/obo/HP_0005895	Radial deviation of thumb terminal phalanx	http://purl.obolibrary.org/obo/HP_0009617	Abnormality of the distal phalanx of the thumb		
http://purl.obolibrary.org/obo/HP_0009641	Aplasia/Hypoplasia of the distal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009617	Abnormality of the distal phalanx of the thumb		
http://purl.obolibrary.org/obo/HP_0006147	Progressive fusion 2nd-5th proximal interphalangeal joints	http://purl.obolibrary.org/obo/HP_0009700	Finger symphalangism		
http://purl.obolibrary.org/obo/HP_0005048	Synostosis of carpal bones	http://purl.obolibrary.org/obo/HP_0009702	Carpal synostosis		
http://purl.obolibrary.org/obo/HP_0005694	Partial fusion of proximal row of carpal bones	http://purl.obolibrary.org/obo/HP_0009702	Carpal synostosis		
http://purl.obolibrary.org/obo/HP_0006207	Partial fusion of carpals	http://purl.obolibrary.org/obo/HP_0009702	Carpal synostosis		
http://purl.obolibrary.org/obo/HP_0034480	Absent epididymidis	http://purl.obolibrary.org/obo/HP_0009714	Abnormal epididymis morphology		
http://purl.obolibrary.org/obo/HP_0006402	Distal shortening of limbs	http://purl.obolibrary.org/obo/HP_0009826	Limb undergrowth		
http://purl.obolibrary.org/obo/HP_0006865	Sensorimotor polyneuropathy affecting arms more than legs	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0006903	Congenital peripheral neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0006949	Episodic peripheral neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0007133	Progressive peripheral neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0007141	Sensorimotor neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0007178	Motor polyneuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral neuropathy		
http://purl.obolibrary.org/obo/HP_0007327	Mixed demyelinating and axonal polyneuropathy	http://purl.obolibrary.org/obo/HP_0012447	Abnormal myelination		
http://purl.obolibrary.org/obo/HP_0009838	Curved distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009770	Curved phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009839	Osteolytic defects of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009771	Osteolytic defects of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009875	Triangular shaped distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009774	Triangular shaped phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010062	Osteolytic defects of the phalanges of the hallux	http://purl.obolibrary.org/obo/HP_0010057	Abnormal hallux phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010198	Osteolytic defects of the middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010351	Osteolytic defects of the phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010363	Osteolytic defects of the phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010375	Osteolytic defects of the phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0010387	Osteolytic defects of the phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010091	Hallux symphalangism	http://purl.obolibrary.org/obo/HP_0010179	Toe symphalangism		
http://purl.obolibrary.org/obo/HP_0010076	Aplasia/Hypoplasia of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010058	Aplasia/Hypoplasia of the phalanges of the hallux		
http://purl.obolibrary.org/obo/HP_0010413	Aplasia/Hypoplasia of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100369	Aplasia/Hypoplasia of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010368	Abnormality of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100370	Aplasia/Hypoplasia of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010380	Abnormality of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100371	Aplasia/Hypoplasia of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010392	Abnormality of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010080	Osteolytic defects of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010062	Osteolytic defects of the phalanges of the hallux		
http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010343	Aplasia/Hypoplasia of the 5th toe	http://purl.obolibrary.org/obo/HP_0010760	Absent toe		
http://purl.obolibrary.org/obo/HP_0010344	Deviation of the 5th toe	http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes		
http://purl.obolibrary.org/obo/HP_0006157	Prominent palmar flexion creases	http://purl.obolibrary.org/obo/HP_0010490	Abnormality of the palmar creases		
http://purl.obolibrary.org/obo/HP_0006450	Multicentric ossification of proximal femoral epiphyses	http://purl.obolibrary.org/obo/HP_0009107	Abnormal ossification involving the femoral head and neck		
http://purl.obolibrary.org/obo/HP_0004005	Large radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010165	Enlarged epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004004	Irregular radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0005063	Fragmented, irregular epiphyses	http://purl.obolibrary.org/obo/HP_0100168	Fragmented epiphyses		
http://purl.obolibrary.org/obo/HP_0006361	Irregular femoral epiphysis	http://purl.obolibrary.org/obo/HP_0006499	Abnormal femoral epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010167	Irregular epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004010	Small radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010170	Small epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010325	Aplasia/Hypoplasia of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010319	Abnormal second toe morphology		
http://purl.obolibrary.org/obo/HP_0010331	Aplasia/Hypoplasia of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010320	Abnormal third toe morphology		
http://purl.obolibrary.org/obo/HP_0010337	Aplasia/Hypoplasia of the 4th toe	http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology		
http://purl.obolibrary.org/obo/HP_0006514	Intraalveolar nodular calcifications	http://purl.obolibrary.org/obo/HP_0033137	Abnormal pulmonary alveolar system morphology		
http://purl.obolibrary.org/obo/HP_0010770	Pilonidal fistula	http://purl.obolibrary.org/obo/HP_0010767	Sacrococcygeal pilonidal abnormality		
http://purl.obolibrary.org/obo/HP_0025657	Abnormal umbilical blood flow measurement	http://purl.obolibrary.org/obo/HP_0034059	Abnormal fetal physiology		
http://purl.obolibrary.org/obo/HP_0004922	Atypical hyperphenylalaninemia	http://purl.obolibrary.org/obo/HP_0010893	Abnormal circulating phenylalanine concentration		
http://purl.obolibrary.org/obo/HP_0007236	Recurrent subcortical infarcts	http://purl.obolibrary.org/obo/HP_0010993	Abnormal cerebral subcortex morphology		
http://purl.obolibrary.org/obo/HP_0033479	Abnormal circulating bilirubin concentration	http://purl.obolibrary.org/obo/HP_0010995	Abnormal circulating dicarboxylic acid concentration		
http://purl.obolibrary.org/obo/HP_0025279	Migratory	http://purl.obolibrary.org/obo/HP_0011008	Temporal pattern		
http://purl.obolibrary.org/obo/HP_0006673	Reduced systolic function	http://purl.obolibrary.org/obo/HP_0011025	Abnormal cardiovascular system physiology		
http://purl.obolibrary.org/obo/HP_0005571	Increased renal tubular phosphate reabsorption	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		
http://purl.obolibrary.org/obo/HP_0008666	Impaired histidine renal tubular absorption	http://purl.obolibrary.org/obo/HP_0011038	Abnormal renal tubular resorption		
http://purl.obolibrary.org/obo/HP_0008528	Long hairs growing from helix of pinna	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		
http://purl.obolibrary.org/obo/HP_0100810	Pointed helix	http://purl.obolibrary.org/obo/HP_0011039	Abnormal helix morphology		
http://purl.obolibrary.org/obo/HP_0006286	Yellow-brown discoloration of the teeth	http://purl.obolibrary.org/obo/HP_0011073	Abnormality of dental color		
http://purl.obolibrary.org/obo/HP_0007384	Aberrant melanosome maturation	http://purl.obolibrary.org/obo/HP_0011125	Abnormal dermal melanosome morphology		
http://purl.obolibrary.org/obo/HP_0007482	Generalized papillary lesions	http://purl.obolibrary.org/obo/HP_0011354	Generalized abnormality of skin		
http://purl.obolibrary.org/obo/HP_0007439	Generalized keratosis follicularis	http://purl.obolibrary.org/obo/HP_0011368	Epidermal thickening		
http://purl.obolibrary.org/obo/HP_0011391	Abnormal inner ear nerve morphology	http://purl.obolibrary.org/obo/HP_0011390	Abnormal inner ear morphology		
http://purl.obolibrary.org/obo/HP_0004454	Abnormal middle ear reflexes	http://purl.obolibrary.org/obo/HP_0011452	Functional abnormality of the middle ear		
http://purl.obolibrary.org/obo/HP_0007900	Hypoplastic lacrimal duct	http://purl.obolibrary.org/obo/HP_0011481	Abnormal lacrimal duct morphology		
http://purl.obolibrary.org/obo/HP_0007881	Central corneal dystrophy	http://purl.obolibrary.org/obo/HP_0011493	Central opacification of the cornea		
http://purl.obolibrary.org/obo/HP_0011543	Superior-inferior ventricles without criss-cross atrioventricular valves	http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments		
http://purl.obolibrary.org/obo/HP_0011544	L-looping of the right ventricle	http://purl.obolibrary.org/obo/HP_0011534	Abnormal spatial orientation of the cardiac segments		
http://purl.obolibrary.org/obo/HP_0040075	Hypopituitarism	http://purl.obolibrary.org/obo/HP_0011747	Abnormality of the anterior pituitary		
http://purl.obolibrary.org/obo/HP_0040167	Facial papilloma	http://purl.obolibrary.org/obo/HP_0012740	Papilloma		
http://purl.obolibrary.org/obo/HP_0100748	Muscular edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		
http://purl.obolibrary.org/obo/HP_0034370	Abnormal muscle tissue metabolite concentration	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		
http://purl.obolibrary.org/obo/HP_0430004	Frontomalar faciosynostosis	http://purl.obolibrary.org/obo/HP_0011821	Abnormal facial skeleton morphology		
http://purl.obolibrary.org/obo/HP_0040185	Macrothrombocytopenia	http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia		
http://purl.obolibrary.org/obo/HP_0008346	Increased red cell sickling tendency	http://purl.obolibrary.org/obo/HP_0011895	Anemia due to reduced life span of red cells		
http://purl.obolibrary.org/obo/HP_0011597	Right aortic arch with left descending aorta and left ductus arteriosus	http://purl.obolibrary.org/obo/HP_0012020	Right aortic arch		
http://purl.obolibrary.org/obo/HP_0011598	Right aortic arch with retroesophageal left subclavian artery	http://purl.obolibrary.org/obo/HP_0012020	Right aortic arch		
http://purl.obolibrary.org/obo/HP_0006276	Hyperechogenic pancreas	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		
http://purl.obolibrary.org/obo/HP_0100732	Pancreatic fibrosis	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		
http://purl.obolibrary.org/obo/HP_0100844	Pancreatic fistula	http://purl.obolibrary.org/obo/HP_0012090	Abnormal pancreas morphology		
http://purl.obolibrary.org/obo/HP_0031007	Orofacial action-specific dystonia induced by speech	http://purl.obolibrary.org/obo/HP_0012179	Craniofacial dystonia		
http://purl.obolibrary.org/obo/HP_0030453	Abnormal visual electrophysiology	http://purl.obolibrary.org/obo/HP_0012373	Abnormal eye physiology		
http://purl.obolibrary.org/obo/HP_0005609	Gallbladder dysfunction	http://purl.obolibrary.org/obo/HP_0012438	Abnormal gallbladder physiology		
http://purl.obolibrary.org/obo/HP_0007295	Chaotic rapid conjugate ocular movements	http://purl.obolibrary.org/obo/HP_0012547	Abnormal involuntary eye movements		
http://purl.obolibrary.org/obo/HP_0007738	Uncontrolled eye movements	http://purl.obolibrary.org/obo/HP_0012547	Abnormal involuntary eye movements		
http://purl.obolibrary.org/obo/HP_0034482	Abnormal spinal cord physiology	http://purl.obolibrary.org/obo/HP_0012638	Abnormal nervous system physiology		
http://purl.obolibrary.org/obo/HP_0100953	Enlarged interhemispheric fissure	http://purl.obolibrary.org/obo/HP_0012703	Abnormal subarachnoid space morphology		
http://purl.obolibrary.org/obo/HP_0004796	Gastrointestinal obstruction	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		
http://purl.obolibrary.org/obo/HP_0005244	Gastrointestinal infarctions	http://purl.obolibrary.org/obo/HP_0012719	Functional abnormality of the gastrointestinal tract		
http://purl.obolibrary.org/obo/HP_0032166	Unusual gastrointestinal infection	http://purl.obolibrary.org/obo/HP_0032158	Unusual infection by anatomical site		
http://purl.obolibrary.org/obo/HP_0007441	Hyperpigmented/hypopigmented macules	http://purl.obolibrary.org/obo/HP_0009123	Mixed hypo- and hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0006717	Peripheral neuroepithelioma	http://purl.obolibrary.org/obo/HP_0100007	Neoplasm of the peripheral nervous system		
http://purl.obolibrary.org/obo/HP_0030076	Lobular carcinoma in situ	http://purl.obolibrary.org/obo/HP_0100013	Neoplasm of the breast		
http://purl.obolibrary.org/obo/HP_0004271	Cortical thickening of hand bones	http://purl.obolibrary.org/obo/HP_0005926	Abnormal hand cortical bone morphology		
http://purl.obolibrary.org/obo/HP_0010166	Fragmentation of the epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010160	Abnormal toe epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0100262	Synostosis involving digits	http://purl.obolibrary.org/obo/HP_0100240	Synostosis of joints		
http://purl.obolibrary.org/obo/HP_0040276	Adenocarcinoma of the colon	http://purl.obolibrary.org/obo/HP_0040275	Adenocarcinoma of the large intestine		
http://purl.obolibrary.org/obo/HP_0100300	Desmin bodies	http://purl.obolibrary.org/obo/HP_0100303	Muscle fiber cytoplasmatic inclusion bodies		
http://purl.obolibrary.org/obo/HP_0100302	Muscle fiber tubuloreticular inclusions	http://purl.obolibrary.org/obo/HP_0100303	Muscle fiber cytoplasmatic inclusion bodies		
http://purl.obolibrary.org/obo/HP_0100315	Lewy bodies	http://purl.obolibrary.org/obo/HP_0100314	Cerebral inclusion bodies		
http://purl.obolibrary.org/obo/HP_0005617	Bilateral camptodactyly	http://purl.obolibrary.org/obo/HP_0100490	Camptodactyly of finger		
http://purl.obolibrary.org/obo/HP_0030358	Non-small cell lung carcinoma	http://purl.obolibrary.org/obo/HP_0100526	Neoplasm of the lung		
http://purl.obolibrary.org/obo/HP_0005253	Increased anterioposterior diameter of thorax	http://purl.obolibrary.org/obo/HP_0100625	Enlarged thorax		
http://purl.obolibrary.org/obo/HP_0040141	Tardive dyskinesia	http://purl.obolibrary.org/obo/HP_0100660	Dyskinesia		
http://purl.obolibrary.org/obo/HP_0007414	Neonatal wrinkled skin of hands and feet	http://purl.obolibrary.org/obo/HP_0100678	Premature skin wrinkling		
http://purl.obolibrary.org/obo/HP_0100686	Enthesitis	http://purl.obolibrary.org/obo/HP_0100685	Abnormal Sharpey fiber morphology		
http://purl.obolibrary.org/obo/HP_0003960	Exostoses of the forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0007403	Hypertrophy of skin of soles	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		
http://purl.obolibrary.org/obo/HP_0008113	Multiple plantar creases	http://purl.obolibrary.org/obo/HP_0100872	Abnormality of the plantar skin of foot		
http://purl.obolibrary.org/obo/HP_0007690	Map-dot-fingerprint corneal dystrophy	http://purl.obolibrary.org/obo/HP_0200020	Corneal erosion		
http://purl.obolibrary.org/obo/HP_0007755	Juvenile epithelial corneal dystrophy	http://purl.obolibrary.org/obo/HP_0200020	Corneal erosion		
http://purl.obolibrary.org/obo/UBERON_0005613	left dorsal aorta	http://purl.obolibrary.org/obo/UBERON_0003513	trunk blood vessel		
http://purl.obolibrary.org/obo/UBERON_0005622	right dorsal aorta	http://purl.obolibrary.org/obo/UBERON_0003513	trunk blood vessel		
http://purl.obolibrary.org/obo/UBERON_0037458	hair of neck	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		
http://purl.obolibrary.org/obo/UBERON_0037459	hair of limb	http://purl.obolibrary.org/obo/UBERON_0001037	strand of hair		
http://purl.obolibrary.org/obo/UBERON_0001551	vein of hindlimb zeugopod	http://purl.obolibrary.org/obo/UBERON_0004261	lower leg blood vessel		
http://purl.obolibrary.org/obo/UBERON_0036268	pelvic vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		
http://purl.obolibrary.org/obo/UBERON_0039228	sigmoid vein	http://purl.obolibrary.org/obo/UBERON_0001638	vein		
http://purl.obolibrary.org/obo/UBERON_0015838	molar dental pulp	http://purl.obolibrary.org/obo/UBERON_0001754	dental pulp		
http://purl.obolibrary.org/obo/UBERON_0015251	modified sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0001821	sebaceous gland		
http://purl.obolibrary.org/obo/HP_0006533	Bronchodysplasia	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		
http://purl.obolibrary.org/obo/HP_0006539	Bronchial cartilage hypoplasia	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		
http://purl.obolibrary.org/obo/HP_0032970	Traction bronchiolectasis	http://purl.obolibrary.org/obo/HP_0025426	Abnormal bronchus morphology		
http://purl.obolibrary.org/obo/HP_0005308	Pulmonary artery vasoconstriction	http://purl.obolibrary.org/obo/HP_0030967	Abnormal pulmonary artery physiology		
http://purl.obolibrary.org/obo/HP_0005304	Hypoplastic pulmonary veins	http://purl.obolibrary.org/obo/HP_0030968	Abnormal pulmonary vein morphology		
http://purl.obolibrary.org/obo/HP_0011591	Left aortic arch with cervical origin of the right subclavian artery	http://purl.obolibrary.org/obo/HP_0031055	Abnormal branching pattern of left aortic arch		
http://purl.obolibrary.org/obo/HP_0100879	Enlarged ovaries	http://purl.obolibrary.org/obo/HP_0031065	Abnormal ovarian morphology		
http://purl.obolibrary.org/obo/HP_0006441	Lateral humeral condyle aplasia	http://purl.obolibrary.org/obo/HP_0031095	Abnormal humerus morphology		
http://purl.obolibrary.org/obo/HP_0006561	Lipid accumulation in hepatocytes	http://purl.obolibrary.org/obo/HP_0031137	Storage in hepatocytes		
http://purl.obolibrary.org/obo/HP_0034789	Muscular vasculitis	http://purl.obolibrary.org/obo/HP_0034784	Vasculitis by anatomical site		
http://purl.obolibrary.org/obo/HP_0005291	Inflammatory arteriopathy	http://purl.obolibrary.org/obo/HP_0034785	Vasculitis by histology		
http://purl.obolibrary.org/obo/HP_0005300	Nodular inflammatory vasculitis	http://purl.obolibrary.org/obo/HP_0034785	Vasculitis by histology		
http://purl.obolibrary.org/obo/HP_0004048	Narrow joint spaces of wrist	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		
http://purl.obolibrary.org/obo/HP_0004049	Decreased carpal angles of wrist	http://purl.obolibrary.org/obo/HP_0025798	Abnormal wrist morphology		
http://purl.obolibrary.org/obo/CHEBI_35143	hemoglobin	http://purl.obolibrary.org/obo/CHEBI_5386	globin		
http://purl.obolibrary.org/obo/CHEBI_5386	globin	http://purl.obolibrary.org/obo/CHEBI_35137	hemoprotein		
http://purl.obolibrary.org/obo/CHEBI_47017	tetrahydrofuranol	http://purl.obolibrary.org/obo/CHEBI_26912	oxolanes		
http://purl.obolibrary.org/obo/CHEBI_38796	pteroates	http://purl.obolibrary.org/obo/CHEBI_22494	aminobenzoate		
http://purl.obolibrary.org/obo/CHEBI_38316	pyrimidinecarboxylate anion	http://purl.obolibrary.org/obo/CHEBI_35757	monocarboxylic acid anion		
http://purl.obolibrary.org/obo/CHEBI_177917	phenolic steroid	http://purl.obolibrary.org/obo/CHEBI_33853	phenols		
http://purl.obolibrary.org/obo/CHEBI_76282	suberate(2-)	http://purl.obolibrary.org/obo/CHEBI_133291	saturated dicarboxylic acid dianion(2-)		
http://purl.obolibrary.org/obo/CHEBI_15379	dioxygen	http://purl.obolibrary.org/obo/CHEBI_138675	gas molecular entity		
http://purl.obolibrary.org/obo/CHEBI_156255	S-adenosyl-D-methionine	http://purl.obolibrary.org/obo/CHEBI_26830	sulfonium compound		
http://purl.obolibrary.org/obo/CHEBI_42485	formyl group	http://purl.obolibrary.org/obo/CHEBI_27207	univalent carboacyl group		
http://purl.obolibrary.org/obo/CHEBI_46912	ornithinium(1+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_32532	histidinium(2+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_32697	argininium(2+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_46913	ornithinium(2+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_32531	histidinium(1+)	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_32833	threoninium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_32860	valinium	http://purl.obolibrary.org/obo/CHEBI_33719	alpha-amino-acid cation		
http://purl.obolibrary.org/obo/CHEBI_29917	thiol group	http://purl.obolibrary.org/obo/CHEBI_33246	inorganic group		
http://purl.obolibrary.org/obo/CHEBI_33703	amino-acid cation	http://purl.obolibrary.org/obo/CHEBI_25697	organic cation		
http://purl.obolibrary.org/obo/CHEBI_50315	chloronium	http://purl.obolibrary.org/obo/CHEBI_50313	onium cation		
http://purl.obolibrary.org/obo/HP_0006882	Severe hydrocephalus	http://purl.obolibrary.org/obo/HP_0000238	Hydrocephalus		
http://purl.obolibrary.org/obo/HP_0005346	Abnormal facial expression	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the face		
http://purl.obolibrary.org/obo/HP_0040119	Unilateral conductive hearing impairment	http://purl.obolibrary.org/obo/HP_0000405	Conductive hearing impairment		
http://purl.obolibrary.org/obo/HP_0040113	Old-aged sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0000407	Sensorineural hearing impairment		
http://purl.obolibrary.org/obo/HP_0004406	Spontaneous, recurrent epistaxis	http://purl.obolibrary.org/obo/HP_0000421	Epistaxis		
http://purl.obolibrary.org/obo/HP_0007970	Congenital ptosis	http://purl.obolibrary.org/obo/HP_0000508	Ptosis		
http://purl.obolibrary.org/obo/HP_0200068	Nonprogressive visual loss	http://purl.obolibrary.org/obo/HP_0000572	Visual loss		
http://purl.obolibrary.org/obo/HP_0040068	Abnormality of limb bone	http://purl.obolibrary.org/obo/HP_0040064	Abnormality of limbs		
http://purl.obolibrary.org/obo/HP_0004565	Severe platyspondyly	http://purl.obolibrary.org/obo/HP_0000926	Platyspondyly		
http://purl.obolibrary.org/obo/HP_0005752	Flattened moderately deformed vertebrae	http://purl.obolibrary.org/obo/HP_0000926	Platyspondyly		
http://purl.obolibrary.org/obo/HP_0008418	Squared-off platyspondyly	http://purl.obolibrary.org/obo/HP_0000926	Platyspondyly		
http://purl.obolibrary.org/obo/HP_0005595	Generalized hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		
http://purl.obolibrary.org/obo/HP_0007390	Hyperkeratosis with erythema	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		
http://purl.obolibrary.org/obo/HP_0007448	Hyperkeratosis over edematous areas	http://purl.obolibrary.org/obo/HP_0000969	Edema		
http://purl.obolibrary.org/obo/HP_0007490	Linear arrays of macular hyperkeratoses in flexural areas	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		
http://purl.obolibrary.org/obo/HP_0007501	Streaks of hyperkeratosis along each finger onto the palm	http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis		
http://purl.obolibrary.org/obo/HP_0008410	Subungual hyperkeratotic fragments	http://purl.obolibrary.org/obo/HP_0009723	Abnormal subungual morphology		
http://purl.obolibrary.org/obo/HP_0025533	Peau d'orange	http://purl.obolibrary.org/obo/HP_0000969	Edema		
http://purl.obolibrary.org/obo/HP_0007530	Punctate palmoplantar hyperkeratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		
http://purl.obolibrary.org/obo/HP_0007553	Congenital symmetrical palmoplantar keratosis	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		
http://purl.obolibrary.org/obo/HP_0007613	Spinous keratoses of palms and soles	http://purl.obolibrary.org/obo/HP_0000972	Palmoplantar hyperkeratosis		
http://purl.obolibrary.org/obo/HP_0006089	Palmar hyperhidrosis	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		
http://purl.obolibrary.org/obo/HP_0007427	Reticulated skin pigmentation	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0007483	Depigmentation/hyperpigmentation of skin	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0007587	Numerous pigmented freckles	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0007610	Blotching pigmentation of the skin	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0007617	Fine, reticulate skin pigmentation	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0007623	Pigmentation anomalies of sun-exposed skin	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0200015	Symmetric great toe depigmentation	http://purl.obolibrary.org/obo/HP_0001000	Abnormal skin pigmentation		
http://purl.obolibrary.org/obo/HP_0008376	Nasal dysarthria	http://purl.obolibrary.org/obo/HP_0001260	Dysarthria		
http://purl.obolibrary.org/obo/HP_0005472	Orbital craniosynostosis	http://purl.obolibrary.org/obo/HP_3000030	Abnormal morphology of bony orbit of skull		
http://purl.obolibrary.org/obo/HP_0005059	Arthralgia/arthritis	http://purl.obolibrary.org/obo/HP_0002829	Arthralgia		
http://purl.obolibrary.org/obo/HP_0033037	Migratory arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		
http://purl.obolibrary.org/obo/HP_0005681	Juvenile rheumatoid arthritis	http://purl.obolibrary.org/obo/HP_0001370	Rheumatoid arthritis		
http://purl.obolibrary.org/obo/HP_0005008	Large joint dislocations	http://purl.obolibrary.org/obo/HP_0001373	Joint dislocation		
http://purl.obolibrary.org/obo/HP_0006243	Phalangeal dislocation	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0006688	Paroxysmal tachycardia	http://purl.obolibrary.org/obo/HP_0001649	Tachycardia		
http://purl.obolibrary.org/obo/HP_0004696	Talipes cavus equinovarus	http://purl.obolibrary.org/obo/HP_0001762	Talipes equinovarus		
http://purl.obolibrary.org/obo/HP_0005505	Refractory anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		
http://purl.obolibrary.org/obo/HP_0200136	Oral-pharyngeal dysphagia	http://purl.obolibrary.org/obo/HP_0002015	Dysphagia		
http://purl.obolibrary.org/obo/HP_0005943	Respiratory arrest	http://purl.obolibrary.org/obo/HP_0002093	Respiratory insufficiency		
http://purl.obolibrary.org/obo/HP_0200073	Respiratory insufficiency due to defective ciliary clearance	http://purl.obolibrary.org/obo/HP_0012261	Abnormal respiratory motile cilium physiology		
http://purl.obolibrary.org/obo/HP_0004885	Episodic respiratory distress	http://purl.obolibrary.org/obo/HP_0002098	Respiratory distress		
http://purl.obolibrary.org/obo/HP_0005828	Transient pulmonary infiltrates	http://purl.obolibrary.org/obo/HP_0002113	Pulmonary infiltrates		
http://purl.obolibrary.org/obo/HP_0008394	Congenital onychodystrophy	http://purl.obolibrary.org/obo/HP_0002164	Nail dysplasia		
http://purl.obolibrary.org/obo/HP_0007272	Progressive psychomotor deterioration	http://purl.obolibrary.org/obo/HP_0002344	Progressive neurologic deterioration		
http://purl.obolibrary.org/obo/HP_0007017	Progressive forgetfulness	http://purl.obolibrary.org/obo/HP_0002354	Memory impairment		
http://purl.obolibrary.org/obo/HP_0006904	Late-onset spinocerebellar degeneration	http://purl.obolibrary.org/obo/HP_0002503	Spinocerebellar tract degeneration		
http://purl.obolibrary.org/obo/HP_0007232	Spinocerebellar tract disease in lower limbs	http://purl.obolibrary.org/obo/HP_0002503	Spinocerebellar tract degeneration		
http://purl.obolibrary.org/obo/HP_0040183	Encopresis	http://purl.obolibrary.org/obo/HP_0002607	Bowel incontinence		
http://purl.obolibrary.org/obo/HP_0005010	Osteomyelitis leading to amputation due to slow healing fractures	http://purl.obolibrary.org/obo/HP_0002754	Osteomyelitis		
http://purl.obolibrary.org/obo/HP_0200083	Severe limb shortening	http://purl.obolibrary.org/obo/HP_0002983	Micromelia		
http://purl.obolibrary.org/obo/HP_0008273	Transient aminoaciduria	http://purl.obolibrary.org/obo/HP_0003355	Aminoaciduria		
http://purl.obolibrary.org/obo/HP_0008970	Scapulohumeral muscular dystrophy	http://purl.obolibrary.org/obo/HP_0003560	Muscular dystrophy		
http://purl.obolibrary.org/obo/HP_0008929	Asymmetric short stature	http://purl.obolibrary.org/obo/HP_0004322	Short stature		
http://purl.obolibrary.org/obo/HP_0006515	Interstitial pneumonitis	http://purl.obolibrary.org/obo/HP_0006530	Abnormal pulmonary interstitial morphology		
http://purl.obolibrary.org/obo/HP_0006572	Subacute progressive viral hepatitis	http://purl.obolibrary.org/obo/HP_0006562	Viral hepatitis		
http://purl.obolibrary.org/obo/HP_0008890	Severe short-limb dwarfism	http://purl.obolibrary.org/obo/HP_0008873	Disproportionate short-limb short stature		
http://purl.obolibrary.org/obo/HP_0008909	Lethal short-limbed short stature	http://purl.obolibrary.org/obo/HP_0008873	Disproportionate short-limb short stature		
http://purl.obolibrary.org/obo/HP_0011405	Childhood onset short-limb short stature	http://purl.obolibrary.org/obo/HP_0008873	Disproportionate short-limb short stature		
http://purl.obolibrary.org/obo/HP_0009059	Congenital generalized lipodystrophy	http://purl.obolibrary.org/obo/HP_0009125	Lipodystrophy		
http://purl.obolibrary.org/obo/HP_0005700	Increased bone density with cystic changes	http://purl.obolibrary.org/obo/HP_0011001	Increased bone mineral density		
http://purl.obolibrary.org/obo/HP_0007473	Crusting erythematous dermatitis	http://purl.obolibrary.org/obo/HP_0011123	Inflammatory abnormality of the skin		
http://purl.obolibrary.org/obo/UBERON_0000005	chemosensory organ	http://purl.obolibrary.org/obo/UBERON_0000020	sense organ		
http://purl.obolibrary.org/obo/UBERON_0035764	pulmonary lymph node	http://purl.obolibrary.org/obo/UBERON_0000029	lymph node		
http://purl.obolibrary.org/obo/UBERON_0005282	ventricular system of brain	http://purl.obolibrary.org/obo/UBERON_0000467	anatomical system		
http://purl.obolibrary.org/obo/UBERON_0005726	chemosensory system	http://purl.obolibrary.org/obo/UBERON_0001032	sensory system		
http://purl.obolibrary.org/obo/UBERON_0007037	mechanosensory system	http://purl.obolibrary.org/obo/UBERON_0001032	sensory system		
http://purl.obolibrary.org/obo/UBERON_0008713	pectoral girdle and thoracic body wall skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0001134	skeletal muscle tissue		
http://purl.obolibrary.org/obo/UBERON_0009657	artery of lip	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0039355	urethral artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0039261	pancreatic artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0035039	rectal artery	http://purl.obolibrary.org/obo/UBERON_0001637	artery		
http://purl.obolibrary.org/obo/UBERON_0001712	upper eyelid	http://purl.obolibrary.org/obo/UBERON_0001711	eyelid		
http://purl.obolibrary.org/obo/UBERON_0001713	lower eyelid	http://purl.obolibrary.org/obo/UBERON_0001711	eyelid		
http://purl.obolibrary.org/obo/UBERON_0035767	intrapulmonary bronchus	http://purl.obolibrary.org/obo/UBERON_0002185	bronchus		
http://purl.obolibrary.org/obo/UBERON_0019231	manual digit 1 or 5	http://purl.obolibrary.org/obo/UBERON_0019221	digit 1 or 5		
http://purl.obolibrary.org/obo/UBERON_0019232	manual digit 2, 3 or 4	http://purl.obolibrary.org/obo/UBERON_0019222	digit 2, 3 or 4		
http://purl.obolibrary.org/obo/UBERON_0005604	extrahepatic part of hepatic duct	http://purl.obolibrary.org/obo/UBERON_0002394	bile duct		
http://purl.obolibrary.org/obo/HP_0031652	Abnormal aortic valve physiology	http://purl.obolibrary.org/obo/HP_0031653	Abnormal heart valve physiology		
http://purl.obolibrary.org/obo/HP_0005201	Anomalous splenoportal venous system	http://purl.obolibrary.org/obo/HP_0031941	Abnormal portal venous system morphology		
http://purl.obolibrary.org/obo/HP_0033288	Glomerular basement membrane spikes	http://purl.obolibrary.org/obo/HP_0033282	Abnormal glomerular basement membrane morphology		
http://purl.obolibrary.org/obo/HP_0025745	Abnormal urine amino acid level	http://purl.obolibrary.org/obo/HP_0033354	Abnormal urine metabolite level		
http://purl.obolibrary.org/obo/HP_0006986	Upper limb spasticity	http://purl.obolibrary.org/obo/HP_0034353	Appendicular spasticity		
http://purl.obolibrary.org/obo/CHEBI_28838	lutein	http://purl.obolibrary.org/obo/CHEBI_23045	carotenol		
http://purl.obolibrary.org/obo/CHEBI_35148	(6'S)-beta,epsilon-carotene	http://purl.obolibrary.org/obo/CHEBI_28425	alpha-carotene		
http://purl.obolibrary.org/obo/CHEBI_32457	cysteinate(2-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_32530	histidinate(2-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_32785	tyrosinate(2-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_32529	histidinate(1-)	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_32832	threoninate	http://purl.obolibrary.org/obo/CHEBI_33558	alpha-amino-acid anion		
http://purl.obolibrary.org/obo/CHEBI_48378	carboximidic acid	http://purl.obolibrary.org/obo/CHEBI_48377	imidic acid		
http://purl.obolibrary.org/obo/CHEBI_33767	cobalt group molecular entity	http://purl.obolibrary.org/obo/CHEBI_33676	d-block molecular entity		
http://purl.obolibrary.org/obo/CHEBI_176718	octadecatrienoylcarnitine	http://purl.obolibrary.org/obo/CHEBI_17387	O-acylcarnitine		
http://purl.obolibrary.org/obo/CHEBI_33729	tetritol	http://purl.obolibrary.org/obo/CHEBI_17522	alditol		
http://purl.obolibrary.org/obo/CHEBI_35134	metalloprotein	http://purl.obolibrary.org/obo/CHEBI_33837	conjugated protein		
http://purl.obolibrary.org/obo/CHEBI_26981	threitol	http://purl.obolibrary.org/obo/CHEBI_48299	butane-1,2,3,4-tetrol		
http://purl.obolibrary.org/obo/CHEBI_33431	elemental chlorine	http://purl.obolibrary.org/obo/CHEBI_33434	elemental halogen		
http://purl.obolibrary.org/obo/CHEBI_33424	sulfur oxoacid derivative	http://purl.obolibrary.org/obo/CHEBI_33241	oxoacid derivative		
http://purl.obolibrary.org/obo/CHEBI_41609	carbonate	http://purl.obolibrary.org/obo/CHEBI_35604	carbon oxoanion		
http://purl.obolibrary.org/obo/CHEBI_38793	pteroate	http://purl.obolibrary.org/obo/CHEBI_38796	pteroates		
http://purl.obolibrary.org/obo/CHEBI_37826	sulfuric acid derivative	http://purl.obolibrary.org/obo/CHEBI_33424	sulfur oxoacid derivative		
http://purl.obolibrary.org/obo/CHEBI_37827	thiosulfuric acid derivative	http://purl.obolibrary.org/obo/CHEBI_33424	sulfur oxoacid derivative		
http://purl.obolibrary.org/obo/CHEBI_33358	cobalt group element atom	http://purl.obolibrary.org/obo/CHEBI_27081	transition element atom		
http://purl.obolibrary.org/obo/CHEBI_33366	copper group element atom	http://purl.obolibrary.org/obo/CHEBI_27081	transition element atom		
http://purl.obolibrary.org/obo/CHEBI_33635	polycyclic compound	http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound		
http://purl.obolibrary.org/obo/CHEBI_33661	monocyclic compound	http://purl.obolibrary.org/obo/CHEBI_33595	cyclic compound		
http://purl.obolibrary.org/obo/CHEBI_33664	monocyclic hydrocarbon	http://purl.obolibrary.org/obo/CHEBI_33663	cyclic hydrocarbon		
http://purl.obolibrary.org/obo/CHEBI_37175	organic hydride	http://purl.obolibrary.org/obo/CHEBI_33692	hydrides		
http://purl.obolibrary.org/obo/CHEBI_33888	cobalt molecular entity	http://purl.obolibrary.org/obo/CHEBI_33767	cobalt group molecular entity		
http://purl.obolibrary.org/obo/CHEBI_47018	monohydroxytetrahydrofuran	http://purl.obolibrary.org/obo/CHEBI_47017	tetrahydrofuranol		
http://purl.obolibrary.org/obo/CHEBI_47019	dihydroxytetrahydrofuran	http://purl.obolibrary.org/obo/CHEBI_47017	tetrahydrofuranol		
http://purl.obolibrary.org/obo/NBO_0000403	voluntary movement behavior	http://purl.obolibrary.org/obo/NBO_0000001	body part movement		
http://purl.obolibrary.org/obo/HP_0003985	Exostoses of the ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		
http://purl.obolibrary.org/obo/HP_0003987	Fractured ulna	http://purl.obolibrary.org/obo/HP_0025736	Long-bone fracture		
http://purl.obolibrary.org/obo/HP_0004017	Exostoses of the radial metaphysis	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0003998	Constricted radial neck	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004001	Medially deficient radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004006	Round radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004007	Sclerotic radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004008	Sloping radial epiphyses	http://purl.obolibrary.org/obo/HP_0003999	Abnormal radial epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004003	Medially flattened radial epiphyses	http://purl.obolibrary.org/obo/HP_0004002	Flattened radial epiphyses		
http://purl.obolibrary.org/obo/HP_0004009	Medially sloping radial epiphyses	http://purl.obolibrary.org/obo/HP_0004008	Sloping radial epiphyses		
http://purl.obolibrary.org/obo/HP_0004013	Medially fused radial epiphyseal plates	http://purl.obolibrary.org/obo/HP_0004012	Premature fusion of the radial epiphyseal plates		
http://purl.obolibrary.org/obo/HP_0004023	Sloping radial metaphysis	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004025	Spurred radial metaphysis	http://purl.obolibrary.org/obo/HP_0004015	Abnormal radial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004024	Medially sloping radial metaphysis	http://purl.obolibrary.org/obo/HP_0004023	Sloping radial metaphysis		
http://purl.obolibrary.org/obo/HP_0004028	Spurs of radial diaphysis	http://purl.obolibrary.org/obo/HP_0004027	Abnormality of radial diaphysis		
http://purl.obolibrary.org/obo/HP_0004029	Lytic defects of radial diaphysis	http://purl.obolibrary.org/obo/HP_0004027	Abnormality of radial diaphysis		
http://purl.obolibrary.org/obo/HP_0004030	Patchy sclerosis of radial diaphysis	http://purl.obolibrary.org/obo/HP_0004027	Abnormality of radial diaphysis		
http://purl.obolibrary.org/obo/HP_0004033	Curved olecranon	http://purl.obolibrary.org/obo/HP_0004032	Abnormal olecranon morphology		
http://purl.obolibrary.org/obo/HP_0004034	Irregular olecranon	http://purl.obolibrary.org/obo/HP_0004032	Abnormal olecranon morphology		
http://purl.obolibrary.org/obo/HP_0004036	Long styloid process of ulna	http://purl.obolibrary.org/obo/HP_0004035	Abnormal ulnar styloid process morphology		
http://purl.obolibrary.org/obo/HP_0004981	Prominent styloid process of ulna	http://purl.obolibrary.org/obo/HP_0004035	Abnormal ulnar styloid process morphology		
http://purl.obolibrary.org/obo/HP_0005068	Absent styloid process of ulna	http://purl.obolibrary.org/obo/HP_0004035	Abnormal ulnar styloid process morphology		
http://purl.obolibrary.org/obo/HP_0004035	Abnormal ulnar styloid process morphology	http://purl.obolibrary.org/obo/HP_0004037	Abnormal ulnar epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0004040	Corner fragments of ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004041	Cupped ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004043	Lytic defects of ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0045039	Osteolysis involving bones of the upper limbs		
http://purl.obolibrary.org/obo/HP_0004044	Pointed ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004039	Abnormal ulnar metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004240	Sclerotic foci within carpal bones	http://purl.obolibrary.org/obo/HP_0009164	Abnormal calcification of the carpal bones		
http://purl.obolibrary.org/obo/HP_0004281	Irregular sclerosis of hand bones	http://purl.obolibrary.org/obo/HP_0004054	Sclerosis of hand bone		
http://purl.obolibrary.org/obo/HP_0009549	Curved phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009770	Curved phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0040019	Finger clinodactyly	http://purl.obolibrary.org/obo/HP_0030084	Clinodactyly		
http://purl.obolibrary.org/obo/HP_0009946	Polydactyly affecting the 2nd finger	http://purl.obolibrary.org/obo/HP_0006159	Mesoaxial hand polydactyly		
http://purl.obolibrary.org/obo/HP_0009958	Polydactyly affecting the 3rd finger	http://purl.obolibrary.org/obo/HP_0006159	Mesoaxial hand polydactyly		
http://purl.obolibrary.org/obo/HP_0009334	Abnormality of the epiphysis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009437	Aplasia/Hypoplasia of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009447	Aplasia/Hypoplasia of the phalanges of the 3rd finger		
http://purl.obolibrary.org/obo/HP_0009971	Polydactyly affecting the 4th finger	http://purl.obolibrary.org/obo/HP_0006159	Mesoaxial hand polydactyly		
http://purl.obolibrary.org/obo/HP_0004219	Abnormality of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0004213	Abnormal 5th finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009239	Aplasia/Hypoplasia of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009376	Aplasia/Hypoplasia of the phalanges of the 5th finger		
http://purl.obolibrary.org/obo/HP_0004249	Accessory lunate	http://purl.obolibrary.org/obo/HP_0004248	Abnormal lunate bone morphology		
http://purl.obolibrary.org/obo/HP_0004245	Comma-shaped scaphoid	http://purl.obolibrary.org/obo/HP_0004243	Abnormal scaphoid morphology		
http://purl.obolibrary.org/obo/HP_0004242	Broad carpal bones	http://purl.obolibrary.org/obo/HP_0004237	Large carpal bones		
http://purl.obolibrary.org/obo/HP_0004250	Proximally placed lunate	http://purl.obolibrary.org/obo/HP_0004248	Abnormal lunate bone morphology		
http://purl.obolibrary.org/obo/HP_0004261	Wide hamate bone	http://purl.obolibrary.org/obo/HP_0004260	Large hamate bone		
http://purl.obolibrary.org/obo/HP_0006202	Osteolysis of scaphoids	http://purl.obolibrary.org/obo/HP_0009699	Osteolytic defects of the hand bones		
http://purl.obolibrary.org/obo/HP_0045003	Abnormal ossification of the scaphoid	http://purl.obolibrary.org/obo/HP_0004243	Abnormal scaphoid morphology		
http://purl.obolibrary.org/obo/HP_0006106	Absent trapezoid bone	http://purl.obolibrary.org/obo/HP_0004256	Abnormal trapezoid bone morphology		
http://purl.obolibrary.org/obo/HP_0006226	Osteoarthritis of the first carpometacarpal joint	http://purl.obolibrary.org/obo/HP_0004268	Osteoarthritis of the small joints of the hand		
http://purl.obolibrary.org/obo/HP_0006233	Osteoarthritis of the distal interphalangeal joint	http://purl.obolibrary.org/obo/HP_0004268	Osteoarthritis of the small joints of the hand		
http://purl.obolibrary.org/obo/HP_0004291	Stippled calcification of hand bones	http://purl.obolibrary.org/obo/HP_0004280	Irregular ossification of hand bones		
http://purl.obolibrary.org/obo/HP_0004286	Patchy sclerosis of hand bones	http://purl.obolibrary.org/obo/HP_0004281	Irregular sclerosis of hand bones		
http://purl.obolibrary.org/obo/HP_0004289	Sclerotic foci in hand bones	http://purl.obolibrary.org/obo/HP_0004281	Irregular sclerosis of hand bones		
http://purl.obolibrary.org/obo/HP_0004290	Sclerosis of hand bones with transverse striations	http://purl.obolibrary.org/obo/HP_0004281	Irregular sclerosis of hand bones		
http://purl.obolibrary.org/obo/HP_0005747	Easily subluxated first metacarpophalangeal joints	http://purl.obolibrary.org/obo/HP_0004294	Subluxation of metacarpal phalangeal joints		
http://purl.obolibrary.org/obo/HP_0005451	Decreased cranial base ossification	http://purl.obolibrary.org/obo/HP_0004331	Decreased skull ossification		
http://purl.obolibrary.org/obo/HP_0100496	Abnormal circulating vitamin B3 concentration	http://purl.obolibrary.org/obo/HP_0004340	Abnormal circulating vitamin B concentration		
http://purl.obolibrary.org/obo/HP_0008497	Congenital craniofacial dysostosis	http://purl.obolibrary.org/obo/HP_0004439	Craniofacial dysostosis		
http://purl.obolibrary.org/obo/HP_0004822	Atypical elliptocytosis	http://purl.obolibrary.org/obo/HP_0004445	Elliptocytosis		
http://purl.obolibrary.org/obo/HP_0040120	Abnormality of the reflex of the tensor tympani muscle	http://purl.obolibrary.org/obo/HP_0004454	Abnormal middle ear reflexes		
http://purl.obolibrary.org/obo/HP_0007536	Aplasia cutis congenita of midline scalp vertex	http://purl.obolibrary.org/obo/HP_0004471	Aplasia cutis congenita over the scalp vertex		
http://purl.obolibrary.org/obo/HP_0007590	Aplasia cutis congenita over posterior parietal area	http://purl.obolibrary.org/obo/HP_0004476	Aplasia cutis congenita over parietal area		
http://purl.obolibrary.org/obo/HP_0008452	Wafer-thin platyspondyly	http://purl.obolibrary.org/obo/HP_0004565	Severe platyspondyly		
http://purl.obolibrary.org/obo/HP_0004562	Beaking of vertebral bodies T12-L3	http://purl.obolibrary.org/obo/HP_0004568	Beaking of vertebral bodies		
http://purl.obolibrary.org/obo/HP_0004581	Increased anterior vertebral height	http://purl.obolibrary.org/obo/HP_0004570	Increased vertebral height		
http://purl.obolibrary.org/obo/HP_0008421	Tall lumbar vertebral bodies	http://purl.obolibrary.org/obo/HP_0004570	Increased vertebral height		
http://purl.obolibrary.org/obo/HP_0008475	Hypoplastic sacral vertebrae	http://purl.obolibrary.org/obo/HP_0008417	Vertebral hypoplasia		
http://purl.obolibrary.org/obo/HP_0008435	Absent in utero ossification of vertebral bodies	http://purl.obolibrary.org/obo/HP_0004606	Unossified vertebral bodies		
http://purl.obolibrary.org/obo/HP_0008425	Cuboid-shaped thoracolumbar vertebral bodies	http://purl.obolibrary.org/obo/HP_0004634	Cuboid-shaped vertebral bodies		
http://purl.obolibrary.org/obo/HP_0033286	Thickened glomerular basement membranes with electron dense deposits	http://purl.obolibrary.org/obo/HP_0004722	Thickened glomerular basement membrane		
http://purl.obolibrary.org/obo/HP_0006671	Paroxysmal atrial tachycardia	http://purl.obolibrary.org/obo/HP_0004763	Paroxysmal supraventricular tachycardia		
http://purl.obolibrary.org/obo/HP_0005249	Functional intestinal obstruction	http://purl.obolibrary.org/obo/HP_0004796	Gastrointestinal obstruction		
http://purl.obolibrary.org/obo/HP_0005941	Intermittent hyperpnea at rest	http://purl.obolibrary.org/obo/HP_0004879	Intermittent hyperventilation		
http://purl.obolibrary.org/obo/HP_0005946	Ventilator dependence with inability to wean	http://purl.obolibrary.org/obo/HP_0004887	Respiratory failure requiring assisted ventilation		
http://purl.obolibrary.org/obo/HP_0004919	Galactose intolerance	http://purl.obolibrary.org/obo/HP_0004915	Impairment of galactose metabolism		
http://purl.obolibrary.org/obo/HP_0005316	Peripheral pulmonary vessel aplasia	http://purl.obolibrary.org/obo/HP_0004930	Abnormality of the pulmonary vasculature		
http://purl.obolibrary.org/obo/HP_0005191	Congenital knee dislocation	http://purl.obolibrary.org/obo/HP_0004976	Knee dislocation		
http://purl.obolibrary.org/obo/HP_0006694	Early progressive calcific cardiac valvular disease	http://purl.obolibrary.org/obo/HP_0005146	Cardiac valve calcification		
http://purl.obolibrary.org/obo/HP_0005764	Polyarticular arthritis	http://purl.obolibrary.org/obo/HP_0005195	Polyarticular arthropathy		
http://purl.obolibrary.org/obo/HP_0100769	Synovitis	http://purl.obolibrary.org/obo/HP_0005262	Abnormal synovial membrane morphology		
http://purl.obolibrary.org/obo/HP_0005314	Anomalous branches of internal carotid artery	http://purl.obolibrary.org/obo/HP_0005344	Abnormal carotid artery morphology		
http://purl.obolibrary.org/obo/HP_0004886	Congenital laryngeal stridor	http://purl.obolibrary.org/obo/HP_0005348	Inspiratory stridor		
http://purl.obolibrary.org/obo/HP_0005951	Progressive inspiratory stridor	http://purl.obolibrary.org/obo/HP_0005348	Inspiratory stridor		
http://purl.obolibrary.org/obo/HP_0005494	Premature posterior fontanelle closure	http://purl.obolibrary.org/obo/HP_0005458	Premature closure of fontanelles		
http://purl.obolibrary.org/obo/HP_0012129	Abnormality of bone marrow stromal cells	http://purl.obolibrary.org/obo/HP_0005561	Abnormal bone marrow cell morphology		
http://purl.obolibrary.org/obo/HP_0007603	Freckles in sun-exposed areas	http://purl.obolibrary.org/obo/HP_0005586	Hyperpigmentation in sun-exposed areas		
http://purl.obolibrary.org/obo/HP_0006201	Hypermobility of distal interphalangeal joints	http://purl.obolibrary.org/obo/HP_0005620	Hypermobility of interphalangeal joints		
http://purl.obolibrary.org/obo/HP_0005612	Arthrogryposis-like hand anomaly	http://purl.obolibrary.org/obo/HP_0005684	Distal arthrogryposis		
http://purl.obolibrary.org/obo/HP_0005766	Disproportionate shortening of the tibia	http://purl.obolibrary.org/obo/HP_0005736	Short tibia		
http://purl.obolibrary.org/obo/HP_0006379	Proximal tibial hypoplasia	http://purl.obolibrary.org/obo/HP_0005736	Short tibia		
http://purl.obolibrary.org/obo/HP_0007293	Anterior sacral meningocele	http://purl.obolibrary.org/obo/HP_0005765	Sacral meningocele		
http://purl.obolibrary.org/obo/HP_0006426	Rudimentary to absent tibiae	http://purl.obolibrary.org/obo/HP_0005772	Aplasia/Hypoplasia of the tibia		
http://purl.obolibrary.org/obo/HP_0007627	Mandibular condyle aplasia	http://purl.obolibrary.org/obo/HP_0005790	Short mandibular condyles		
http://purl.obolibrary.org/obo/HP_0007628	Mandibular condyle hypoplasia	http://purl.obolibrary.org/obo/HP_0005790	Short mandibular condyles		
http://purl.obolibrary.org/obo/HP_0030294	Metaphyseal chondromatosis of tibia	http://purl.obolibrary.org/obo/HP_0005868	Metaphyseal enchondromatosis		
http://purl.obolibrary.org/obo/HP_0030295	Metaphyseal chondromatosis of femur	http://purl.obolibrary.org/obo/HP_0005868	Metaphyseal enchondromatosis		
http://purl.obolibrary.org/obo/HP_0030296	Metaphyseal chondromatosis of radius	http://purl.obolibrary.org/obo/HP_0005868	Metaphyseal enchondromatosis		
http://purl.obolibrary.org/obo/HP_0030297	Metaphyseal chondromatosis of ulna	http://purl.obolibrary.org/obo/HP_0005868	Metaphyseal enchondromatosis		
http://purl.obolibrary.org/obo/HP_0030298	Metaphyseal chondromatosis of humerus	http://purl.obolibrary.org/obo/HP_0005868	Metaphyseal enchondromatosis		
http://purl.obolibrary.org/obo/HP_0008462	Cervical instability	http://purl.obolibrary.org/obo/HP_0005881	Spinal instability		
http://purl.obolibrary.org/obo/HP_0007560	Unusual dermatoglyphics	http://purl.obolibrary.org/obo/HP_0005882	Dermatoglyphic variants		
http://purl.obolibrary.org/obo/HP_0007566	Index finger dermatoglyphic radial loop	http://purl.obolibrary.org/obo/HP_0005882	Dermatoglyphic variants		
http://purl.obolibrary.org/obo/HP_0200113	Aphalangy of hands and feet	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0200050	Bracket metacarpal epiphyses	http://purl.obolibrary.org/obo/HP_0005913	Abnormal metacarpal epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009770	Curved phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009774	Triangular shaped phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand	http://purl.obolibrary.org/obo/HP_0005918	Abnormal finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0006213	Thin proximal phalanges with broad epiphyses of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0004273	Cupped metaphyses of hand bones	http://purl.obolibrary.org/obo/HP_0005923	Abnormal hand metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0004288	Pseudoepiphyses of hand bones	http://purl.obolibrary.org/obo/HP_0010584	Pseudoepiphyses		
http://purl.obolibrary.org/obo/HP_0006026	Rounded epiphyses	http://purl.obolibrary.org/obo/HP_0005924	Abnormal hand epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0006543	Cardiorespiratory arrest	http://purl.obolibrary.org/obo/HP_0005943	Respiratory arrest		
http://purl.obolibrary.org/obo/HP_0006552	Fibrocystic lung disease	http://purl.obolibrary.org/obo/HP_0005948	Multiple pulmonary cysts		
http://purl.obolibrary.org/obo/HP_0006200	Widened distal phalanges	http://purl.obolibrary.org/obo/HP_0006009	Broad phalanx		
http://purl.obolibrary.org/obo/HP_0004235	Comma-shaped carpal bones	http://purl.obolibrary.org/obo/HP_0006014	Abnormally shaped carpal bones		
http://purl.obolibrary.org/obo/HP_0006149	Increased laxity of fingers	http://purl.obolibrary.org/obo/HP_0006094	Finger joint hypermobility		
http://purl.obolibrary.org/obo/HP_0006169	Decreased mobility 3rd-5th fingers	http://purl.obolibrary.org/obo/HP_0006135	Decreased finger mobility		
http://purl.obolibrary.org/obo/HP_0006095	Wide tufts of distal phalanges	http://purl.obolibrary.org/obo/HP_0006200	Widened distal phalanges		
http://purl.obolibrary.org/obo/HP_0006167	Prominent proximal interphalangeal joints	http://purl.obolibrary.org/obo/HP_0006237	Prominent interphalangeal joints		
http://purl.obolibrary.org/obo/HP_0006185	Enlarged proximal interphalangeal joints	http://purl.obolibrary.org/obo/HP_0006247	Enlarged interphalangeal joints		
http://purl.obolibrary.org/obo/HP_0006251	Limited wrist extension	http://purl.obolibrary.org/obo/HP_0006248	Limited wrist movement		
http://purl.obolibrary.org/obo/HP_0006135	Decreased finger mobility	http://purl.obolibrary.org/obo/HP_0006256	Abnormality of hand joint mobility		
http://purl.obolibrary.org/obo/HP_0004267	Narrow small joints of the hand	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006019	Reduced proximal interphalangeal joint space	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006162	Soft tissue swelling of interphalangeal joints	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006163	Enlarged metacarpophalangeal joints	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006217	Limited mobility of proximal interphalangeal joint	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006237	Prominent interphalangeal joints	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006252	Interphalangeal joint erosions	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006253	Swelling of proximal interphalangeal joints	http://purl.obolibrary.org/obo/HP_0006261	Abnormal phalangeal joint morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006209	Partial-complete absence of 5th phalanges	http://purl.obolibrary.org/obo/HP_0006262	Aplasia/Hypoplasia of the 5th finger		
http://purl.obolibrary.org/obo/HP_0009499	Abnormality of the epiphysis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0009500	Abnormality of the epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009501	Abnormality of the epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0006165	Proportionate shortening of all digits	http://purl.obolibrary.org/obo/HP_0006265	Aplasia/Hypoplasia of fingers		
http://purl.obolibrary.org/obo/HP_0006471	Fixed elbow flexion	http://purl.obolibrary.org/obo/HP_0006376	Limited elbow flexion		
http://purl.obolibrary.org/obo/HP_0006279	Beta-cell dysfunction	http://purl.obolibrary.org/obo/HP_0006476	Abnormality of the pancreatic islet cells		
http://purl.obolibrary.org/obo/HP_0006413	Broad tibial metaphyses	http://purl.obolibrary.org/obo/HP_0006491	Abnormal tibial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0006423	Peg-like central prominence of distal tibial metaphyses	http://purl.obolibrary.org/obo/HP_0006491	Abnormal tibial metaphysis morphology		
http://purl.obolibrary.org/obo/HP_0009817	Aplasia involving bones of the lower limbs	http://purl.obolibrary.org/obo/HP_0009825	Aplasia involving bones of the extremities		
http://purl.obolibrary.org/obo/HP_0009823	Aplasia involving bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0009825	Aplasia involving bones of the extremities		
http://purl.obolibrary.org/obo/HP_0010593	Abnormal fibular epiphysis morphology	http://purl.obolibrary.org/obo/HP_0006500	Abnormal lower limb epiphysis morphology		
http://purl.obolibrary.org/obo/HP_0010592	Abnormality of the distal tibial epiphysis	http://purl.obolibrary.org/obo/HP_0006508	Abnormality of tibial epiphyses		
http://purl.obolibrary.org/obo/HP_0006670	Impaired myocardial contractility	http://purl.obolibrary.org/obo/HP_0006673	Reduced systolic function		
http://purl.obolibrary.org/obo/HP_0005147	Bidirectional ventricular ectopy	http://purl.obolibrary.org/obo/HP_0006682	Premature ventricular contraction		
http://purl.obolibrary.org/obo/HP_0006696	Polymorphic and polytopic ventricular extrasystoles	http://purl.obolibrary.org/obo/HP_0006682	Premature ventricular contraction		
http://purl.obolibrary.org/obo/HP_0004394	Multiple gastric polyps	http://purl.obolibrary.org/obo/HP_0006753	Neoplasm of the stomach		
http://purl.obolibrary.org/obo/HP_0006965	Acute necrotizing encephalopathy	http://purl.obolibrary.org/obo/HP_0006846	Acute encephalopathy		
http://purl.obolibrary.org/obo/HP_0007069	Profound static encephalopathy	http://purl.obolibrary.org/obo/HP_0007030	Nonprogressive encephalopathy		
http://purl.obolibrary.org/obo/HP_0006992	Anterior basal encephalocele	http://purl.obolibrary.org/obo/HP_0007035	Anterior encephalocele		
http://purl.obolibrary.org/obo/HP_0007280	Acute infantile spinal muscular atrophy	http://purl.obolibrary.org/obo/HP_0007269	Spinal muscular atrophy		
http://purl.obolibrary.org/obo/HP_0009037	Segmental spinal muscular atrophy	http://purl.obolibrary.org/obo/HP_0007269	Spinal muscular atrophy		
http://purl.obolibrary.org/obo/HP_0011818	Nasofrontal encephalocele	http://purl.obolibrary.org/obo/HP_0007330	Frontoethmoidal encephalocele		
http://purl.obolibrary.org/obo/HP_0006827	Atrophy of the spinal cord	http://purl.obolibrary.org/obo/HP_0007344	Atrophy/Degeneration involving the spinal cord		
http://purl.obolibrary.org/obo/HP_0007348	Hypoplasia of the pyramidal tract	http://purl.obolibrary.org/obo/HP_0007363	Aplasia/Hypoplasia of the pyramidal tract		
http://purl.obolibrary.org/obo/HP_0100322	Aplasia of the pyramidal tract	http://purl.obolibrary.org/obo/HP_0007363	Aplasia/Hypoplasia of the pyramidal tract		
http://purl.obolibrary.org/obo/HP_0007016	Corticospinal tract hypoplasia	http://purl.obolibrary.org/obo/HP_0007365	Aplasia/Hypoplasia involving the corticospinal tracts		
http://purl.obolibrary.org/obo/HP_0007506	Congenital absence of skin of limbs	http://purl.obolibrary.org/obo/HP_0007383	Congenital localized absence of skin		
http://purl.obolibrary.org/obo/HP_0040043	Hypoplasia of the eccrine sweat glands	http://purl.obolibrary.org/obo/HP_0007592	Aplasia/Hypoplasia of the eccrine sweat glands		
http://purl.obolibrary.org/obo/HP_0007407	Excessive skin wrinkling on dorsum of hands and fingers	http://purl.obolibrary.org/obo/HP_0007392	Excessive wrinkled skin		
http://purl.obolibrary.org/obo/HP_0007605	Excessive wrinkling of palmar skin	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		
http://purl.obolibrary.org/obo/HP_0007574	Generalized bronze hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007440	Generalized hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0007599	Generalized reticulate brown pigmentation	http://purl.obolibrary.org/obo/HP_0007440	Generalized hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0007494	Discrete 2 to 5-mm hyper- and hypopigmented macules	http://purl.obolibrary.org/obo/HP_0007441	Hyperpigmented/hypopigmented macules		
http://purl.obolibrary.org/obo/HP_0007425	Hyperextensible skin of face	http://purl.obolibrary.org/obo/HP_0007458	Focal hyperextensible skin		
http://purl.obolibrary.org/obo/HP_0011930	Hyperextensible skin of chest	http://purl.obolibrary.org/obo/HP_0007458	Focal hyperextensible skin		
http://purl.obolibrary.org/obo/HP_0100761	Visceral angiomatosis	http://purl.obolibrary.org/obo/HP_0007461	Hemangiomatosis		
http://purl.obolibrary.org/obo/HP_0007504	Diffuse slow skin atrophy	http://purl.obolibrary.org/obo/HP_0007488	Diffuse skin atrophy		
http://purl.obolibrary.org/obo/HP_0007581	Mediosternal, longitudinal streak of hypopigmentation	http://purl.obolibrary.org/obo/HP_0007535	Hypopigmented streaks		
http://purl.obolibrary.org/obo/HP_0040042	Aplasia of the eccrine sweat glands	http://purl.obolibrary.org/obo/HP_0011136	Aplasia of the sweat glands		
http://purl.obolibrary.org/obo/HP_0010925	Nuclear punctate cataract	http://purl.obolibrary.org/obo/HP_0100018	Nuclear cataract		
http://purl.obolibrary.org/obo/HP_0040031	Chorioretinal hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007661	Abnormality of chorioretinal pigmentation		
http://purl.obolibrary.org/obo/HP_0030532	Visual acuity test abnormality	http://purl.obolibrary.org/obo/HP_0007663	Reduced visual acuity		
http://purl.obolibrary.org/obo/HP_0200066	Ribbonlike corneal degeneration	http://purl.obolibrary.org/obo/HP_0007705	Corneal degeneration		
http://purl.obolibrary.org/obo/HP_0008039	Subepithelial corneal opacities	http://purl.obolibrary.org/obo/HP_0007727	Opacification of the corneal epithelium		
http://purl.obolibrary.org/obo/HP_0007964	Degenerative vitreoretinopathy	http://purl.obolibrary.org/obo/HP_0007773	Vitreoretinopathy		
http://purl.obolibrary.org/obo/HP_0030490	Exudative vitreoretinopathy	http://purl.obolibrary.org/obo/HP_0007773	Vitreoretinopathy		
http://purl.obolibrary.org/obo/HP_0007935	Juvenile posterior subcapsular lenticular opacities	http://purl.obolibrary.org/obo/HP_0007787	Posterior subcapsular cataract		
http://purl.obolibrary.org/obo/HP_0100690	Mosaic central corneal dystrophy	http://purl.obolibrary.org/obo/HP_0007881	Central corneal dystrophy		
http://purl.obolibrary.org/obo/HP_0007760	Crystalline corneal dystrophy	http://purl.obolibrary.org/obo/HP_0007856	Punctate opacification of the cornea		
http://purl.obolibrary.org/obo/HP_0030461	Abnormal timing of flash visual evoked potentials	http://purl.obolibrary.org/obo/HP_0007928	Abnormal flash visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030463	Asymmetrical distribution of flash visual evoked potentials	http://purl.obolibrary.org/obo/HP_0007928	Abnormal flash visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0007779	Anterior segment of eye aplasia	http://purl.obolibrary.org/obo/HP_0008062	Aplasia/Hypoplasia affecting the anterior segment of the eye		
http://purl.obolibrary.org/obo/HP_0007503	Generalized ichthyosis	http://purl.obolibrary.org/obo/HP_0008064	Ichthyosis		
http://purl.obolibrary.org/obo/HP_0007559	Localized epidermolytic hyperkeratosis	http://purl.obolibrary.org/obo/HP_0008064	Ichthyosis		
http://purl.obolibrary.org/obo/HP_0008647	Pubertal developmental failure in females	http://purl.obolibrary.org/obo/HP_0008197	Absence of pubertal development		
http://purl.obolibrary.org/obo/HP_0008231	Macronodular adrenal hyperplasia	http://purl.obolibrary.org/obo/HP_0008221	Adrenal hyperplasia		
http://purl.obolibrary.org/obo/HP_0008225	Thyroid follicular hyperplasia	http://purl.obolibrary.org/obo/HP_0008249	Thyroid hyperplasia		
http://purl.obolibrary.org/obo/HP_0030472	Abnormal light-adapted single flash electroretinogram	http://purl.obolibrary.org/obo/HP_0008275	Abnormal light-adapted electroretinogram		
http://purl.obolibrary.org/obo/HP_0030473	Abnormal light-adapted flicker electroretinogram	http://purl.obolibrary.org/obo/HP_0008275	Abnormal light-adapted electroretinogram		
http://purl.obolibrary.org/obo/HP_0004916	Generalized distal tubular acidosis	http://purl.obolibrary.org/obo/HP_0008341	Distal renal tubular acidosis		
http://purl.obolibrary.org/obo/HP_0010058	Aplasia/Hypoplasia of the phalanges of the hallux	http://purl.obolibrary.org/obo/HP_0010173	Aplasia/Hypoplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0005682	Talocalcaneal synostosis	http://purl.obolibrary.org/obo/HP_0008368	Tarsal synostosis		
http://purl.obolibrary.org/obo/HP_0005802	Coalescence of tarsal bones	http://purl.obolibrary.org/obo/HP_0008368	Tarsal synostosis		
http://purl.obolibrary.org/obo/HP_0008097	Partial fusion of tarsals	http://purl.obolibrary.org/obo/HP_0008368	Tarsal synostosis		
http://purl.obolibrary.org/obo/HP_0008424	Hypoplastic 5th lumbar vertebrae	http://purl.obolibrary.org/obo/HP_0008417	Vertebral hypoplasia		
http://purl.obolibrary.org/obo/HP_0008434	Hypoplastic cervical vertebrae	http://purl.obolibrary.org/obo/HP_0011041	Aplasia/Hypoplasia of the cervical spine		
http://purl.obolibrary.org/obo/HP_0008447	Hypoplastic coccygeal vertebrae	http://purl.obolibrary.org/obo/HP_0008417	Vertebral hypoplasia		
http://purl.obolibrary.org/obo/HP_0008451	Posterior vertebral hypoplasia	http://purl.obolibrary.org/obo/HP_0008417	Vertebral hypoplasia		
http://purl.obolibrary.org/obo/HP_0008463	Central vertebral hypoplasia	http://purl.obolibrary.org/obo/HP_0008417	Vertebral hypoplasia		
http://purl.obolibrary.org/obo/HP_0008414	Lumbar kyphosis in infancy	http://purl.obolibrary.org/obo/HP_0008454	Lumbar kyphosis		
http://purl.obolibrary.org/obo/HP_0005638	Decreased anterioposterior diameter of lumbar vertebral bodies	http://purl.obolibrary.org/obo/HP_0008473	Narrow anterio-posterior vertebral body diameter		
http://purl.obolibrary.org/obo/HP_0008009	Three rows of eyelashes	http://purl.obolibrary.org/obo/HP_0008496	Multiple rows of eyelashes		
http://purl.obolibrary.org/obo/HP_0008464	Absent spinous processes of lower thoracic and lumbar vertebrae	http://purl.obolibrary.org/obo/HP_0008516	Abnormality of the vertebral spinous processes		
http://purl.obolibrary.org/obo/HP_0008436	Absent/hypoplastic coccyx	http://purl.obolibrary.org/obo/HP_0008517	Aplasia/Hypoplasia of the sacrum		
http://purl.obolibrary.org/obo/HP_0008559	Hypoplastic superior helix	http://purl.obolibrary.org/obo/HP_0008589	Hypoplastic helices		
http://purl.obolibrary.org/obo/HP_0008664	Urethral sphincter sclerosis	http://purl.obolibrary.org/obo/HP_0008661	Urethral stenosis		
http://purl.obolibrary.org/obo/HP_0100720	Hypoplasia of the ear cartilage	http://purl.obolibrary.org/obo/HP_0008772	Aplasia/Hypoplasia of the external ear		
http://purl.obolibrary.org/obo/HP_0040191	Rectus femoris muscle atrophy	http://purl.obolibrary.org/obo/HP_0009050	Quadriceps muscle atrophy		
http://purl.obolibrary.org/obo/HP_0009100	Thick anterior alveolar ridges	http://purl.obolibrary.org/obo/HP_0009085	Alveolar ridge overgrowth		
http://purl.obolibrary.org/obo/HP_0100862	Aplasia of the femoral head	http://purl.obolibrary.org/obo/HP_0009108	Aplasia/Hypoplasia involving the femoral head and neck		
http://purl.obolibrary.org/obo/HP_0100863	Aplasia of the femoral neck	http://purl.obolibrary.org/obo/HP_0009108	Aplasia/Hypoplasia involving the femoral head and neck		
http://purl.obolibrary.org/obo/HP_0007402	Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines	http://purl.obolibrary.org/obo/HP_0009123	Mixed hypo- and hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0007471	Axillary and groin hyperpigmentation and hypopigmentation	http://purl.obolibrary.org/obo/HP_0009123	Mixed hypo- and hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0007509	Patchy hypo- and hyperpigmentation	http://purl.obolibrary.org/obo/HP_0009123	Mixed hypo- and hyperpigmentation of the skin		
http://purl.obolibrary.org/obo/HP_0010025	Triangular epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010014	Abnormality of the epiphysis of the 1st metacarpal		
http://purl.obolibrary.org/obo/HP_0009282	Abnormality of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009172	Abnormal 4th finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009283	Abnormality of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009172	Abnormal 4th finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009284	Abnormality of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009172	Abnormal 4th finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009408	Aplasia/Hypoplasia of the phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009247	Abnormality of the epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009248	Abnormality of the epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009249	Abnormality of the epiphysis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0006179	Pseudoepiphyses of second metacarpal	http://purl.obolibrary.org/obo/HP_0010220	Abnormality of the epiphysis of the 2nd metacarpal		
http://purl.obolibrary.org/obo/HP_0010015	Absent epiphysis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010268	Absent epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0040025	Clinodactyly of the 4th finger	http://purl.obolibrary.org/obo/HP_0040019	Finger clinodactyly		
http://purl.obolibrary.org/obo/HP_0009289	Aplasia/Hypoplasia of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009408	Aplasia/Hypoplasia of the phalanges of the 4th finger		
http://purl.obolibrary.org/obo/HP_0009299	Aplasia/Hypoplasia of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009408	Aplasia/Hypoplasia of the phalanges of the 4th finger		
http://purl.obolibrary.org/obo/HP_0009288	Curved proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009854	Curved proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009300	Aplasia/Hypoplasia of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009408	Aplasia/Hypoplasia of the phalanges of the 4th finger		
http://purl.obolibrary.org/obo/HP_0004172	Abnormality of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009316	Abnormal 3rd finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009357	Abnormality of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009316	Abnormal 3rd finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009358	Abnormality of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009316	Abnormal 3rd finger phalanx morphology		
http://purl.obolibrary.org/obo/HP_0009447	Aplasia/Hypoplasia of the phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0040024	Clinodactyly of the 3rd finger	http://purl.obolibrary.org/obo/HP_0040019	Finger clinodactyly		
http://purl.obolibrary.org/obo/HP_0009332	Abnormality of the epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0009333	Abnormality of the epiphysis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009421	Aplasia/Hypoplasia of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009447	Aplasia/Hypoplasia of the phalanges of the 3rd finger		
http://purl.obolibrary.org/obo/HP_0009457	Aplasia/Hypoplasia of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009447	Aplasia/Hypoplasia of the phalanges of the 3rd finger		
http://purl.obolibrary.org/obo/HP_0009371	Type A1 brachydactyly	http://purl.obolibrary.org/obo/HP_0009370	Type A brachydactyly		
http://purl.obolibrary.org/obo/HP_0009372	Type A2 brachydactyly	http://purl.obolibrary.org/obo/HP_0009370	Type A brachydactyly		
http://purl.obolibrary.org/obo/HP_0006190	Radially deviated wrists	http://purl.obolibrary.org/obo/HP_0009486	Radial deviation of the hand		
http://purl.obolibrary.org/obo/HP_0006055	Ulnar deviated club hands	http://purl.obolibrary.org/obo/HP_0009487	Ulnar deviation of the hand		
http://purl.obolibrary.org/obo/HP_0009513	Absent epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010257	Absent epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009524	Absent epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010268	Absent epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009515	Cone-shaped epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010259	Cone-shaped epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009526	Cone-shaped epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010270	Cone-shaped epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009516	Enlarged epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010260	Enlarged epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009527	Enlarged epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010271	Enlarged epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009517	Fragmentation of the epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010261	Fragmentation of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009528	Fragmentation of the epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010272	Fragmentation of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009518	Irregular epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010262	Irregular epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009529	Irregular epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010273	Irregular epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009519	Ivory epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010263	Ivory epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009530	Ivory epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010274	Ivory epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009521	Small epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010265	Small epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009532	Small epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010276	Small epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009522	Stippling of the epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010266	Stippling of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009533	Stippling of the epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010277	Stippling of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009523	Triangular epiphysis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010267	Triangular epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009534	Triangular epiphysis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0010278	Triangular epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009565	Aplasia of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009881	Aplasia of distal finger phalanx		
http://purl.obolibrary.org/obo/HP_0009542	Abnormality of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009541	Abnormality of the phalanges of the 2nd finger		
http://purl.obolibrary.org/obo/HP_0009543	Abnormality of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009541	Abnormality of the phalanges of the 2nd finger		
http://purl.obolibrary.org/obo/HP_0009544	Abnormality of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009541	Abnormality of the phalanges of the 2nd finger		
http://purl.obolibrary.org/obo/HP_0009547	Broad phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009550	Osteolytic defects of the phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009771	Osteolytic defects of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009552	Aplasia/Hypoplasia of the phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009557	Aplasia/Hypoplasia of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009552	Aplasia/Hypoplasia of the phalanges of the 2nd finger		
http://purl.obolibrary.org/obo/HP_0009568	Aplasia/Hypoplasia of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009552	Aplasia/Hypoplasia of the phalanges of the 2nd finger		
http://purl.obolibrary.org/obo/HP_0009580	Aplasia/Hypoplasia of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009552	Aplasia/Hypoplasia of the phalanges of the 2nd finger		
http://purl.obolibrary.org/obo/HP_0030509	Retinal racemose hemangioma	http://purl.obolibrary.org/obo/HP_0009594	Retinal hamartoma		
http://purl.obolibrary.org/obo/HP_0030510	Combined hamartoma of the retinal pigment epithelium and retina	http://purl.obolibrary.org/obo/HP_0009594	Retinal hamartoma		
http://purl.obolibrary.org/obo/HP_0009696	Triangular epiphyses of the thumb	http://purl.obolibrary.org/obo/HP_0010238	Triangular epiphyses of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009658	Aplasia/Hypoplasia of the phalanges of the thumb	http://purl.obolibrary.org/obo/HP_0009767	Aplasia/Hypoplasia of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0100922	Sclerosis of thumb phalanx	http://purl.obolibrary.org/obo/HP_0100899	Sclerosis of finger phalanx		
http://purl.obolibrary.org/obo/HP_0009705	Synostosis involving the 2nd metacarpal	http://purl.obolibrary.org/obo/HP_0010010	Abnormal 2nd metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0009706	Synostosis involving the 3rd metacarpal	http://purl.obolibrary.org/obo/HP_0010011	Abnormal 3rd metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0009707	Synostosis involving the 4th metacarpal	http://purl.obolibrary.org/obo/HP_0010012	Abnormal 4th metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0009708	Synostosis involving the 5th metacarpal	http://purl.obolibrary.org/obo/HP_0010013	Abnormal 5th metacarpal morphology		
http://purl.obolibrary.org/obo/HP_0005867	4-5 metacarpal synostosis	http://purl.obolibrary.org/obo/HP_0009708	Synostosis involving the 5th metacarpal		
http://purl.obolibrary.org/obo/HP_0009843	Aplasia/Hypoplasia of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0009851	Aplasia/Hypoplasia of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0006112	Expanded phalanges with widened medullary cavities	http://purl.obolibrary.org/obo/HP_0009768	Broad phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0009846	Curved middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0009854	Curved proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0009847	Osteolytic defects of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0009855	Osteolytic defects of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0009850	Triangular shaped middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009833	Abnormal middle phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0009858	Triangular shaped proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0005726	Thumbs hypoplastic with bulbous tips	http://purl.obolibrary.org/obo/HP_0009778	Short thumb		
http://purl.obolibrary.org/obo/HP_0006045	Short pointed phalanges	http://purl.obolibrary.org/obo/HP_0009803	Short phalanx of finger		
http://purl.obolibrary.org/obo/HP_0006060	Tombstone-shaped proximal phalanges	http://purl.obolibrary.org/obo/HP_0009834	Abnormal proximal phalanx morphology of the hand		
http://purl.obolibrary.org/obo/HP_0008537	Cleft at the superior portion of the pinna	http://purl.obolibrary.org/obo/HP_0009902	Cleft helix		
http://purl.obolibrary.org/obo/HP_0006040	Long second metacarpal	http://purl.obolibrary.org/obo/HP_0010036	Aplasia/Hypoplasia of the 2nd metacarpal		
http://purl.obolibrary.org/obo/HP_0006161	Short metacarpals with rounded proximal ends	http://purl.obolibrary.org/obo/HP_0010049	Short metacarpal		
http://purl.obolibrary.org/obo/HP_0010085	Aplasia/Hypoplasia of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010194	Aplasia/Hypoplasia of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010089	Osteolytic defects of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010198	Osteolytic defects of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010090	Patchy sclerosis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0100943	Sclerosis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010092	Triangular shaped proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010201	Triangular shaped middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010083	Triangular shaped distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010192	Triangular shaped distal phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010084	Duplication of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010193	Duplication of distal phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100944	Sclerosis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0100948	Sclerosis of distal phalanx of toe		
http://purl.obolibrary.org/obo/HP_0010072	Patchy sclerosis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0100945	Sclerosis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010073	Synostosis involving the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010054	Abnormality of the first metatarsal bone		
http://purl.obolibrary.org/obo/HP_0010074	Triangular shaped 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010065	Triangular shaped phalanges of the hallux		
http://purl.obolibrary.org/obo/HP_0008111	Broad distal hallux	http://purl.obolibrary.org/obo/HP_0010055	Broad hallux		
http://purl.obolibrary.org/obo/HP_0010114	Bracket epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010163	Bracket epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010115	Cone-shaped epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010164	Cone-shaped epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010116	Enlarged epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010165	Enlarged epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010117	Fragmentation of the epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010166	Fragmentation of the epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010118	Irregular epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010167	Irregular epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010119	Ivory epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010168	Ivory epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010120	Pseudoepiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010169	Pseudoepiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010121	Small epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010170	Small epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010123	Triangular epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010172	Triangular epiphyses of the toes		
http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010056	Abnormality of the epiphyses of the hallux		
http://purl.obolibrary.org/obo/HP_0010053	Abnormality of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010065	Triangular shaped phalanges of the hallux	http://purl.obolibrary.org/obo/HP_0010180	Triangular shaped phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010110	Aplasia of the phalanges of the hallux	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010081	Patchy sclerosis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0100944	Sclerosis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010101	Partial duplication of the phalanges of the hallux	http://purl.obolibrary.org/obo/HP_0010066	Duplication of phalanx of hallux		
http://purl.obolibrary.org/obo/HP_0010102	Aplasia of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010645	Aplasia of the distal phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010096	Complete duplication of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010100	Complete duplication of hallux phalanx		
http://purl.obolibrary.org/obo/HP_0010097	Partial duplication of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010101	Partial duplication of the phalanges of the hallux		
http://purl.obolibrary.org/obo/HP_0010106	Aplasia of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0100388	Aplasia of the proximal phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010328	Polydactyly affecting the 2nd toe	http://purl.obolibrary.org/obo/HP_0010319	Abnormal second toe morphology		
http://purl.obolibrary.org/obo/HP_0010334	Polydactyly affecting the 3rd toe	http://purl.obolibrary.org/obo/HP_0010320	Abnormal third toe morphology		
http://purl.obolibrary.org/obo/HP_0010340	Polydactyly affecting the 4th toe	http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology		
http://purl.obolibrary.org/obo/HP_0010129	Cone-shaped epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010140	Cone-shaped epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010130	Enlarged epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010141	Enlarged epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010152	Enlarged epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010131	Fragmentation of the epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010142	Fragmentation of the epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010153	Fragmentation of the epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010132	Irregular epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010143	Irregular epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010154	Irregular epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010133	Ivory epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010144	Ivory epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010145	Pseudoepiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010135	Small epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010146	Small epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010137	Triangular epiphysis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010126	Abnormality of the epiphysis of the proximal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010148	Triangular epiphysis of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010124	Abnormality of the epiphysis of the distal phalanx of the hallux		
http://purl.obolibrary.org/obo/HP_0010156	Pseudoepiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010157	Small epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010158	Stippling of the epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010159	Triangular epiphysis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010125	Abnormality of the epiphysis of the 1st metatarsal		
http://purl.obolibrary.org/obo/HP_0010163	Bracket epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010578	Bracket epiphyses		
http://purl.obolibrary.org/obo/HP_0010164	Cone-shaped epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0034281	Phalangeal cone-shaped epiphyses		
http://purl.obolibrary.org/obo/HP_0010168	Ivory epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010583	Ivory epiphyses		
http://purl.obolibrary.org/obo/HP_0010169	Pseudoepiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010584	Pseudoepiphyses		
http://purl.obolibrary.org/obo/HP_0010172	Triangular epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010587	Triangular epiphysis		
http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010319	Abnormal second toe morphology		
http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010320	Abnormal third toe morphology		
http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology		
http://purl.obolibrary.org/obo/HP_0010180	Triangular shaped phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010161	Abnormal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010320	Abnormal third toe morphology		
http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010321	Abnormal fourth toe morphology		
http://purl.obolibrary.org/obo/HP_0100044	Absent epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100055	Absent epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100066	Absent epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100077	Absent epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100045	Bracket epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100056	Bracket epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100067	Bracket epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100078	Bracket epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100046	Cone-shaped epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100057	Cone-shaped epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100068	Cone-shaped epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100079	Cone-shaped epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100047	Enlarged epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100058	Enlarged epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100069	Enlarged epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100080	Enlarged epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100048	Fragmentation of the epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100059	Fragmentation of the epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100070	Fragmentation of the epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100081	Fragmentation of the epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100049	Irregular epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100060	Irregular epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100071	Irregular epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100082	Irregular epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100051	Pseudoepiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100062	Pseudoepiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100073	Pseudoepiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100084	Pseudoepiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100052	Small epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100063	Small epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100074	Small epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100085	Small epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100054	Triangular epiphyses of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100065	Triangular epiphyses of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100076	Triangular epiphyses of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100087	Triangular epiphyses of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010194	Aplasia/Hypoplasia of the middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010347	Aplasia/Hypoplasia of the phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010359	Aplasia/Hypoplasia of the phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010371	Aplasia/Hypoplasia of the phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0010383	Aplasia/Hypoplasia of the phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010746	Hypoplasia of the phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010173	Aplasia/Hypoplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010195	Broad middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010348	Broad phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010360	Broad phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010372	Broad phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0010384	Broad phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010192	Triangular shaped distal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010201	Triangular shaped middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010210	Triangular shaped proximal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010184	Abnormality of toe proximal phalanx		
http://purl.obolibrary.org/obo/HP_0010354	Triangular shaped phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010366	Triangular shaped phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010378	Triangular shaped phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0010390	Triangular shaped phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010368	Abnormality of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010380	Abnormality of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0010392	Abnormality of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010182	Abnormal distal toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010369	Abnormality of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330	Abnormality of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010381	Abnormality of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010183	Abnormality of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0010393	Abnormality of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010324	Abnormal 2nd toe phalanx morphology		
http://purl.obolibrary.org/obo/HP_0010382	Abnormal morphology of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010336	Abnormality of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0010394	Abnormal morphology of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010342	Abnormality of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010414	Broad distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100431	Broad distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010368	Abnormality of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100432	Broad distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010380	Abnormality of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100433	Broad distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010392	Abnormality of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010418	Patchy sclerosis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100939	Sclerosis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100467	Patchy sclerosis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100940	Sclerosis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010404	Aplasia/Hypoplasia of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100372	Aplasia/Hypoplasia of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010369	Abnormality of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100373	Aplasia/Hypoplasia of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010381	Abnormality of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100374	Aplasia/Hypoplasia of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010393	Abnormality of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010405	Broad middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100425	Broad middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010369	Abnormality of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100426	Broad middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010381	Abnormality of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100427	Broad middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010393	Abnormality of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010409	Patchy sclerosis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100935	Sclerosis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100461	Patchy sclerosis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100936	Sclerosis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010396	Broad proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100428	Broad proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010370	Abnormal morphology of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100429	Broad proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010382	Abnormal morphology of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100430	Broad proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010394	Abnormal morphology of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010400	Patchy sclerosis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100931	Sclerosis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100464	Patchy sclerosis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100932	Sclerosis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0010257	Absent epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010268	Absent epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0006035	Cone-shaped epiphyses of phalanges 2 to 5	http://purl.obolibrary.org/obo/HP_0010230	Cone-shaped epiphyses of the phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010248	Cone-shaped epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010259	Cone-shaped epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010270	Cone-shaped epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010249	Enlarged epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010260	Enlarged epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010271	Enlarged epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010250	Fragmentation of the epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010272	Fragmentation of the epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010251	Irregular epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010262	Irregular epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010273	Irregular epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010254	Small epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010265	Small epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010276	Small epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010255	Stippling of the epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010266	Stippling of the epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010277	Stippling of the epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010256	Triangular epiphyses of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010243	Abnormality of the epiphyses of the distal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0010267	Triangular epiphyses of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010244	Abnormality of the epiphyses of the middle phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0010278	Triangular epiphyses of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010245	Abnormality of the epiphyses of the proximal phalanges of the hand		
http://purl.obolibrary.org/obo/HP_0020342	Unusual stomatitis	http://purl.obolibrary.org/obo/HP_5210280	Unusual oral cavity infection		
http://purl.obolibrary.org/obo/HP_0040044	Hypoplasia of the diaphragm	http://purl.obolibrary.org/obo/HP_0010315	Aplasia/Hypoplasia of the diaphragm		
http://purl.obolibrary.org/obo/HP_0010326	Deviation of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes		
http://purl.obolibrary.org/obo/HP_0010332	Deviation of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes		
http://purl.obolibrary.org/obo/HP_0010338	Deviation of the 4th toe	http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes		
http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010323	Abnormality of the epiphyses of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0010430	Aplasia of the phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100344	Fibular deviation of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010326	Deviation of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100345	Tibial deviation of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010326	Deviation of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010329	Abnormality of the epiphyses of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100362	Aplasia of the phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100342	Fibular deviation of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010332	Deviation of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100343	Tibial deviation of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010332	Deviation of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010335	Abnormality of the epiphyses of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100363	Aplasia of the phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100340	Fibular deviation of the 4th toe	http://purl.obolibrary.org/obo/HP_0010338	Deviation of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100341	Tibial deviation of the 4th toe	http://purl.obolibrary.org/obo/HP_0010338	Deviation of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010341	Abnormality of the epiphyses of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100364	Aplasia of the phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100346	Fibular deviation of the 5th toe	http://purl.obolibrary.org/obo/HP_0010344	Deviation of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100347	Tibial deviation of the 5th toe	http://purl.obolibrary.org/obo/HP_0010344	Deviation of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010399	Osteolytic defects of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0010408	Osteolytic defects of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0010417	Osteolytic defects of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0010402	Triangular shaped proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358	Abnormal morphology of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0010411	Triangular shaped middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357	Abnormality of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0010420	Triangular shaped distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356	Abnormality of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100939	Sclerosis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100948	Sclerosis of distal phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100452	Osteolytic defects of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010363	Osteolytic defects of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100455	Osteolytic defects of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010363	Osteolytic defects of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100458	Osteolytic defects of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010363	Osteolytic defects of the phalanges of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100453	Osteolytic defects of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010375	Osteolytic defects of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100456	Osteolytic defects of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010375	Osteolytic defects of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100459	Osteolytic defects of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0010375	Osteolytic defects of the phalanges of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100454	Osteolytic defects of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010387	Osteolytic defects of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100457	Osteolytic defects of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010387	Osteolytic defects of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100460	Osteolytic defects of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010387	Osteolytic defects of the phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100487	Triangular shaped distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0010390	Triangular shaped phalanges of the 5th toe		
http://purl.obolibrary.org/obo/HP_0010436	Aplasia of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010430	Aplasia of the phalanges of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0010434	Aplasia of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100388	Aplasia of the proximal phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0025770	2-3 finger osseus syndactyly	http://purl.obolibrary.org/obo/HP_0010492	Osseous finger syndactyly		
http://purl.obolibrary.org/obo/HP_0006088	1-5 finger complete cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010554	Cutaneous finger syndactyly		
http://purl.obolibrary.org/obo/HP_0006400	Absent knee epiphyses	http://purl.obolibrary.org/obo/HP_0034669	Abnormal knee morphology		
http://purl.obolibrary.org/obo/HP_0005066	Cone-shaped epiphyses fused within their metaphyses	http://purl.obolibrary.org/obo/HP_0010579	Cone-shaped epiphysis		
http://purl.obolibrary.org/obo/HP_0006449	Distal radial epiphyseal osteolysis	http://purl.obolibrary.org/obo/HP_0010597	Abnormality of the distal radial epiphysis		
http://purl.obolibrary.org/obo/HP_0005709	2-3 toe cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010621	Cutaneous syndactyly of toes		
http://purl.obolibrary.org/obo/HP_0005767	1-2 toe complete cutaneous syndactyly	http://purl.obolibrary.org/obo/HP_0010621	Cutaneous syndactyly of toes		
http://purl.obolibrary.org/obo/HP_0100379	Aplasia of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100370	Aplasia/Hypoplasia of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100380	Aplasia of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100371	Aplasia/Hypoplasia of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0004274	Deficient ossification of hand bones	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		
http://purl.obolibrary.org/obo/HP_0004280	Irregular ossification of hand bones	http://purl.obolibrary.org/obo/HP_0010660	Abnormal hand bone ossification		
http://purl.obolibrary.org/obo/HP_0032336	Increased circulating specific IgE antibody concentration	http://purl.obolibrary.org/obo/HP_0010701	Abnormal circulating immunoglobulin concentration		
http://purl.obolibrary.org/obo/HP_0040091	Asymmetry of the size of ears	http://purl.obolibrary.org/obo/HP_0010722	Asymmetry of the ears		
http://purl.obolibrary.org/obo/HP_0040092	Asymmetry of the shape of the ears	http://purl.obolibrary.org/obo/HP_0010722	Asymmetry of the ears		
http://purl.obolibrary.org/obo/HP_0040093	Asymmetry of the position of the ears	http://purl.obolibrary.org/obo/HP_0010722	Asymmetry of the ears		
http://purl.obolibrary.org/obo/HP_0045018	Partial duplication of eyebrows	http://purl.obolibrary.org/obo/HP_0010730	Double eyebrow		
http://purl.obolibrary.org/obo/HP_0100387	Aplasia of the middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100388	Aplasia of the proximal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010745	Aplasia of the phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0030694	Pineal parenchymal cell neoplasm	http://purl.obolibrary.org/obo/HP_0010799	Pinealoma		
http://purl.obolibrary.org/obo/HP_0200094	Frontal open bite	http://purl.obolibrary.org/obo/HP_0010807	Open bite		
http://purl.obolibrary.org/obo/HP_0008478	Scheuermann-like vertebral changes	http://purl.obolibrary.org/obo/HP_0010891	Morbus Scheuermann		
http://purl.obolibrary.org/obo/HP_0007096	Hypoplasia of the optic tract	http://purl.obolibrary.org/obo/HP_0011000	Aplasia/Hypoplasia of the optic tract		
http://purl.obolibrary.org/obo/HP_0010999	Aplasia of the optic tract	http://purl.obolibrary.org/obo/HP_0011000	Aplasia/Hypoplasia of the optic tract		
http://purl.obolibrary.org/obo/HP_0005572	Decreased renal tubular phosphate excretion	http://purl.obolibrary.org/obo/HP_0011036	Abnormality of renal excretion		
http://purl.obolibrary.org/obo/HP_0008461	Cervical vertebral facet hypoplasia	http://purl.obolibrary.org/obo/HP_0011041	Aplasia/Hypoplasia of the cervical spine		
http://purl.obolibrary.org/obo/HP_0006330	Rotated maxillary central incisors	http://purl.obolibrary.org/obo/HP_0011062	Misalignment of incisors		
http://purl.obolibrary.org/obo/HP_0200116	Distal ileal atresia	http://purl.obolibrary.org/obo/HP_0011102	Ileal atresia		
http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression	http://purl.obolibrary.org/obo/HP_0011124	Abnormal epidermal morphology		
http://purl.obolibrary.org/obo/HP_0010846	EEG with persistent abnormal rhythmic activity	http://purl.obolibrary.org/obo/HP_0011176	EEG with constitutional variants		
http://purl.obolibrary.org/obo/HP_0040150	Epiblepharon of upper lid	http://purl.obolibrary.org/obo/HP_0011225	Epiblepharon		
http://purl.obolibrary.org/obo/HP_0040151	Epiblepharon of lower lid	http://purl.obolibrary.org/obo/HP_0011225	Epiblepharon		
http://purl.obolibrary.org/obo/HP_0045012	Decreased urinary catecholamine concentration	http://purl.obolibrary.org/obo/HP_0011281	Abnormality of urine catecholamine level		
http://purl.obolibrary.org/obo/HP_0040106	Abnormal lateral semicircular canal morphology	http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology		
http://purl.obolibrary.org/obo/HP_0040107	Abnormal posterior semicircular canal morphology	http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology		
http://purl.obolibrary.org/obo/HP_0040108	Abnormal anterior semicircular canal morphology	http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology		
http://purl.obolibrary.org/obo/HP_0040109	Abnormal utricle morphology	http://purl.obolibrary.org/obo/HP_0011380	Abnormal semicircular canal morphology		
http://purl.obolibrary.org/obo/HP_0011392	Abnormality of the vestibular nerve	http://purl.obolibrary.org/obo/HP_0011391	Abnormal inner ear nerve morphology		
http://purl.obolibrary.org/obo/HP_0007006	Dorsal column degeneration	http://purl.obolibrary.org/obo/HP_0011397	Abnormal spinal cord dorsal column morphology		
http://purl.obolibrary.org/obo/HP_0007827	Nodular corneal dystrophy	http://purl.obolibrary.org/obo/HP_0011494	Generalized opacification of the cornea		
http://purl.obolibrary.org/obo/HP_0007658	Large hyperpigmented retinal spots	http://purl.obolibrary.org/obo/HP_0011512	Fundus hyperpigmentation		
http://purl.obolibrary.org/obo/HP_0011549	Univentricular heart with absent left sided atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011547	Absent left sided atrioventricular connection		
http://purl.obolibrary.org/obo/HP_0011550	Biventricular heart with straddling right sided atrioventricular valve and absent left sided atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011547	Absent left sided atrioventricular connection		
http://purl.obolibrary.org/obo/HP_0011551	Right sided atrium to left ventricle and absent left sided atrioventricular connection	http://purl.obolibrary.org/obo/HP_0011547	Absent left sided atrioventricular connection		
http://purl.obolibrary.org/obo/HP_0011558	Double inlet to single ventricle with common atrioventricular orifice	http://purl.obolibrary.org/obo/HP_0011557	Double inlet to single ventricle of indeterminate morphology		
http://purl.obolibrary.org/obo/HP_0011559	Double inlet to single ventricle with two atrioventricular valves	http://purl.obolibrary.org/obo/HP_0011557	Double inlet to single ventricle of indeterminate morphology		
http://purl.obolibrary.org/obo/HP_0011694	Supraventricular tachycardia with a manifest accessory pathway	http://purl.obolibrary.org/obo/HP_0011688	Supraventricular tachycardia with an accessory connection mediated pathway		
http://purl.obolibrary.org/obo/HP_0011691	Supraventricular tachycardia with a concealed accessory pathway on the left free wall	http://purl.obolibrary.org/obo/HP_0011689	Supraventricular tachycardia with a concealed accessory connection		
http://purl.obolibrary.org/obo/HP_0011692	Supraventricular tachycardia with a concealed accessory pathway on the right free wall	http://purl.obolibrary.org/obo/HP_0011689	Supraventricular tachycardia with a concealed accessory connection		
http://purl.obolibrary.org/obo/HP_0011693	Supraventricular tachycardia with a concealed accessory pathway on the septum	http://purl.obolibrary.org/obo/HP_0011689	Supraventricular tachycardia with a concealed accessory connection		
http://purl.obolibrary.org/obo/HP_0011696	Supraventricular tachycardia with a manifest accessory pathway on the left free wall	http://purl.obolibrary.org/obo/HP_0011694	Supraventricular tachycardia with a manifest accessory pathway		
http://purl.obolibrary.org/obo/HP_0011697	Supraventricular tachycardia with a manifest accessory pathway on the right free wall	http://purl.obolibrary.org/obo/HP_0011694	Supraventricular tachycardia with a manifest accessory pathway		
http://purl.obolibrary.org/obo/HP_0011698	Supraventricular tachycardia with a manifest accessory pathway on the septum	http://purl.obolibrary.org/obo/HP_0011694	Supraventricular tachycardia with a manifest accessory pathway		
http://purl.obolibrary.org/obo/HP_0011775	Thyroid macrofollicular adenoma	http://purl.obolibrary.org/obo/HP_0011774	Thyroid follicular adenoma		
http://purl.obolibrary.org/obo/HP_0011776	Thyroid microfollicular adenoma	http://purl.obolibrary.org/obo/HP_0011774	Thyroid follicular adenoma		
http://purl.obolibrary.org/obo/HP_0006642	Large sternal ossification centers	http://purl.obolibrary.org/obo/HP_0011863	Abnormal sternal ossification		
http://purl.obolibrary.org/obo/HP_0006643	Fused sternal ossification centers	http://purl.obolibrary.org/obo/HP_0011863	Abnormal sternal ossification		
http://purl.obolibrary.org/obo/HP_0040015	Increased activity of mitochondrial respiratory chain	http://purl.obolibrary.org/obo/HP_0011922	Abnormal activity of mitochondrial respiratory chain		
http://purl.obolibrary.org/obo/HP_0040013	Decreased mitochondrial number	http://purl.obolibrary.org/obo/HP_0012102	Abnormal mitochondrial number		
http://purl.obolibrary.org/obo/HP_0040014	Increased mitochondrial number	http://purl.obolibrary.org/obo/HP_0012102	Abnormal mitochondrial number		
http://purl.obolibrary.org/obo/HP_0200122	Atypical or prolonged hepatitis	http://purl.obolibrary.org/obo/HP_0012115	Hepatitis		
http://purl.obolibrary.org/obo/HP_0200143	Megaloblastic erythroid hyperplasia	http://purl.obolibrary.org/obo/HP_0012132	Erythroid hyperplasia		
http://purl.obolibrary.org/obo/HP_0012136	Dysplastic granulopoesis	http://purl.obolibrary.org/obo/HP_0012135	Abnormal granulocytopoietic cell morphology		
http://purl.obolibrary.org/obo/HP_0012137	Abnormal number of granulocyte precursors	http://purl.obolibrary.org/obo/HP_0012135	Abnormal granulocytopoietic cell morphology		
http://purl.obolibrary.org/obo/HP_0012138	Granulocytic hyperplasia	http://purl.obolibrary.org/obo/HP_0012137	Abnormal number of granulocyte precursors		
http://purl.obolibrary.org/obo/HP_0200150	Increased serum bile acid concentration during pregnancy	http://purl.obolibrary.org/obo/HP_0012202	Increased serum bile acid concentration		
http://purl.obolibrary.org/obo/HP_0200106	Absent/shortened dynein arms	http://purl.obolibrary.org/obo/HP_0012255	Dynein arm defect of respiratory motile cilia		
http://purl.obolibrary.org/obo/HP_0012263	Immotile cilia	http://purl.obolibrary.org/obo/HP_0012262	Abnormal ciliary motility		
http://purl.obolibrary.org/obo/HP_0006598	Irregular ossification at anterior rib ends	http://purl.obolibrary.org/obo/HP_0012306	Abnormal rib ossification		
http://purl.obolibrary.org/obo/HP_0030516	Homonymous hemianopia	http://purl.obolibrary.org/obo/HP_0012377	Hemianopia		
http://purl.obolibrary.org/obo/HP_0030517	Heteronymous hemianopia	http://purl.obolibrary.org/obo/HP_0012377	Hemianopia		
http://purl.obolibrary.org/obo/HP_0034202	Abnormal iduronate sulfatase concentration	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		
http://purl.obolibrary.org/obo/HP_0034053	Decreased acid ceramidase activity	http://purl.obolibrary.org/obo/HP_0012379	Abnormal circulating enzyme concentration or activity		
http://purl.obolibrary.org/obo/HP_0046506	Pain in head and neck region	http://purl.obolibrary.org/obo/HP_0012531	Pain		
http://purl.obolibrary.org/obo/HP_0025049	Abnormal brain creatine level by MRS	http://purl.obolibrary.org/obo/HP_0012705	Abnormal metabolic brain imaging by MRS		
http://purl.obolibrary.org/obo/HP_0100100	Absent epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100111	Absent epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100122	Absent epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100101	Bracket epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100112	Bracket epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100123	Bracket epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100102	Cone-shaped epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100113	Cone-shaped epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100124	Cone-shaped epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100103	Enlarged epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100114	Enlarged epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100125	Enlarged epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100104	Fragmentation of the epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100115	Fragmentation of the epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100126	Fragmentation of the epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100105	Irregular epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100116	Irregular epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100127	Irregular epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100106	Ivory epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100117	Ivory epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100128	Ivory epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100107	Pseudoepiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100108	Small epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100119	Small epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100130	Small epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100110	Triangular epiphysis of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100121	Triangular epiphysis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100132	Triangular epiphysis of the proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		
http://purl.obolibrary.org/obo/HP_0100135	Absent epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100146	Absent epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100157	Absent epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100136	Bracket epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100147	Bracket epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100158	Bracket epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100137	Cone-shaped epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100148	Cone-shaped epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100159	Cone-shaped epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100138	Enlarged epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100149	Enlarged epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100160	Enlarged epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100139	Fragmentation of the epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100150	Fragmentation of the epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100161	Fragmentation of the epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100140	Irregular epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100151	Irregular epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100162	Irregular epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100141	Ivory epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100152	Ivory epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100163	Ivory epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100142	Pseudoepiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100153	Pseudoepiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100143	Small epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100154	Small epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100165	Small epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100145	Triangular epiphysis of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100156	Triangular epiphysis of the middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100167	Triangular epiphysis of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		
http://purl.obolibrary.org/obo/HP_0100169	Absent epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100180	Absent epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100191	Absent epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100170	Bracket epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100181	Bracket epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100192	Bracket epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100171	Cone-shaped epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100182	Cone-shaped epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100193	Cone-shaped epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100172	Enlarged epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100183	Enlarged epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100194	Enlarged epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100173	Fragmentation of the epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100184	Fragmentation of the epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100195	Fragmentation of the epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100174	Irregular epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100185	Irregular epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100196	Irregular epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100175	Ivory epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100186	Ivory epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100197	Ivory epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100176	Pseudoepiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100177	Small epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100188	Small epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100199	Small epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100179	Triangular epiphysis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094	Abnormality of the epiphysis of the distal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100190	Triangular epiphysis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095	Abnormality of the epiphysis of the middle phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100201	Triangular epiphysis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100202	Absent epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100213	Absent epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100224	Absent epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100203	Bracket epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100214	Bracket epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100225	Bracket epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100204	Cone-shaped epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100215	Cone-shaped epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100226	Cone-shaped epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100205	Enlarged epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100216	Enlarged epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100227	Enlarged epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100206	Fragmentation of the epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100217	Fragmentation of the epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100228	Fragmentation of the epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100207	Irregular epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100218	Irregular epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100229	Irregular epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100208	Ivory epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100219	Ivory epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100230	Ivory epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100209	Pseudoepiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100210	Small epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100221	Small epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100232	Small epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100212	Triangular epiphysis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100097	Abnormality of the epiphysis of the distal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100223	Triangular epiphysis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100098	Abnormality of the epiphysis of the middle phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0100234	Triangular epiphysis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100099	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		
http://purl.obolibrary.org/obo/HP_0006866	Midline central nervous system lipomas	http://purl.obolibrary.org/obo/HP_0100251	Multiple central nervous system lipomas		
http://purl.obolibrary.org/obo/HP_0100254	Stenosis of the medullary cavity of the long bones	http://purl.obolibrary.org/obo/HP_0100253	Abnormality of the medullary cavity of the long bones		
http://purl.obolibrary.org/obo/HP_0100264	Proximal symphalangism	http://purl.obolibrary.org/obo/HP_0100262	Synostosis involving digits		
http://purl.obolibrary.org/obo/HP_0010610	Palmar pits	http://purl.obolibrary.org/obo/HP_0040211	Abnormal skin morphology of the palm		
http://purl.obolibrary.org/obo/HP_0030460	Abnormal timing of pattern reversal visual evoked potentials	http://purl.obolibrary.org/obo/HP_0100289	Abnormality of pattern reversal visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030464	Asymmetrical distribution of pattern reversal visual evoked potentials	http://purl.obolibrary.org/obo/HP_0100289	Abnormality of pattern reversal visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0100334	Unilateral cleft palate	http://purl.obolibrary.org/obo/HP_0100338	Non-midline cleft palate		
http://purl.obolibrary.org/obo/HP_0100382	Aplasia of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100387	Aplasia of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100385	Aplasia of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100388	Aplasia of the proximal phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100383	Aplasia of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100387	Aplasia of the middle phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100386	Aplasia of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100388	Aplasia of the proximal phalanges of the toes		
http://purl.obolibrary.org/obo/HP_0100414	Complete duplication of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100405	Duplication of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100423	Partial duplication of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100405	Duplication of the proximal phalanx of the 4th toe		
http://purl.obolibrary.org/obo/HP_0100499	Tibial deviation of toes	http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes		
http://purl.obolibrary.org/obo/HP_0100500	Fibular deviation of toes	http://purl.obolibrary.org/obo/HP_0100498	Deviation of toes		
http://purl.obolibrary.org/obo/HP_0200118	Malabsorption of Vitamin B12	http://purl.obolibrary.org/obo/HP_0100508	Abnormality of vitamin metabolism		
http://purl.obolibrary.org/obo/HP_0006524	Tracheobronchial leiomyomatosis	http://purl.obolibrary.org/obo/HP_0100552	Neoplasm of the tracheobronchial system		
http://purl.obolibrary.org/obo/HP_0004599	Absent or minimally ossified vertebral bodies	http://purl.obolibrary.org/obo/HP_0100569	Abnormally ossified vertebrae		
http://purl.obolibrary.org/obo/HP_0006722	Small intestine carcinoid	http://purl.obolibrary.org/obo/HP_0100833	Neoplasm of the small intestine		
http://purl.obolibrary.org/obo/HP_0100573	Muscular cardiac diverticulum	http://purl.obolibrary.org/obo/HP_0100571	Cardiac diverticulum		
http://purl.obolibrary.org/obo/HP_0007586	Telangiectases producing 'marbled' skin	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		
http://purl.obolibrary.org/obo/HP_0007621	Telangiectasia of extensor surfaces	http://purl.obolibrary.org/obo/HP_0100585	Telangiectasia of the skin		
http://purl.obolibrary.org/obo/HP_0100624	Corpus cavernosum sclerosis	http://purl.obolibrary.org/obo/HP_0100623	Abnormal corpus cavernosum morphology		
http://purl.obolibrary.org/obo/HP_0034372	Internal tibial torsion	http://purl.obolibrary.org/obo/HP_0100694	Tibial torsion		
http://purl.obolibrary.org/obo/HP_0100709	Reduction of oligodendroglia	http://purl.obolibrary.org/obo/HP_0100706	Abnormal oligodendroglia morphology		
http://purl.obolibrary.org/obo/HP_0200133	Lumbosacral meningocele	http://purl.obolibrary.org/obo/HP_0100712	Abnormal lumbar spine morphology		
http://purl.obolibrary.org/obo/HP_0011415	Calcified placenta	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		
http://purl.obolibrary.org/obo/HP_0011416	Placental infarction	http://purl.obolibrary.org/obo/HP_0100767	Abnormal placenta morphology		
http://purl.obolibrary.org/obo/HP_0100890	Cyst of the ductus choledochus	http://purl.obolibrary.org/obo/HP_0100889	Abnormal ductus choledochus morphology		
http://purl.obolibrary.org/obo/HP_0100900	Sclerosis of the distal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100918	Sclerosis of 2nd finger phalanx		
http://purl.obolibrary.org/obo/HP_0100901	Sclerosis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0100919	Sclerosis of 3rd finger phalanx		
http://purl.obolibrary.org/obo/HP_0100902	Sclerosis of the distal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0100920	Sclerosis of 4th finger phalanx		
http://purl.obolibrary.org/obo/HP_0100903	Sclerosis of the distal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0100921	Sclerosis of 5th finger phalanx		
http://purl.obolibrary.org/obo/HP_0100904	Sclerosis of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100918	Sclerosis of 2nd finger phalanx		
http://purl.obolibrary.org/obo/HP_0100905	Sclerosis of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0100919	Sclerosis of 3rd finger phalanx		
http://purl.obolibrary.org/obo/HP_0100906	Sclerosis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0100920	Sclerosis of 4th finger phalanx		
http://purl.obolibrary.org/obo/HP_0100907	Sclerosis of the middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0100921	Sclerosis of 5th finger phalanx		
http://purl.obolibrary.org/obo/HP_0100908	Sclerosis of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100918	Sclerosis of 2nd finger phalanx		
http://purl.obolibrary.org/obo/HP_0100909	Sclerosis of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0100919	Sclerosis of 3rd finger phalanx		
http://purl.obolibrary.org/obo/HP_0100910	Sclerosis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0100920	Sclerosis of 4th finger phalanx		
http://purl.obolibrary.org/obo/HP_0100911	Sclerosis of the proximal phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0100921	Sclerosis of 5th finger phalanx		
http://purl.obolibrary.org/obo/HP_0100914	Sclerosis of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0100917	Sclerosis of proximal phalanx of finger		
http://purl.obolibrary.org/obo/HP_0100935	Sclerosis of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100947	Sclerosis of middle phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100933	Sclerosis of the proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100946	Sclerosis of proximal phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100937	Sclerosis of the middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100947	Sclerosis of middle phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100941	Sclerosis of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100948	Sclerosis of distal phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100934	Sclerosis of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100946	Sclerosis of proximal phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100938	Sclerosis of the middle phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100947	Sclerosis of middle phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100942	Sclerosis of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100948	Sclerosis of distal phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100943	Sclerosis of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0100947	Sclerosis of middle phalanx of toe		
http://purl.obolibrary.org/obo/HP_0100945	Sclerosis of the 1st metatarsal	http://purl.obolibrary.org/obo/HP_0100930	Sclerosis of hallux phalanx		
http://purl.obolibrary.org/obo/HP_0007835	S-shaped palpebral fissures	http://purl.obolibrary.org/obo/HP_0200005	Abnormal shape of the palpebral fissure		
http://purl.obolibrary.org/obo/HP_0005238	Discrete intestinal polyps	http://purl.obolibrary.org/obo/HP_0200008	Intestinal polyposis		
http://purl.obolibrary.org/obo/HP_0200012	Short corpus callosum	http://purl.obolibrary.org/obo/HP_0200011	Abnormal length of corpus callosum		
http://purl.obolibrary.org/obo/HP_0200030	Punctate vasculitis skin lesions	http://purl.obolibrary.org/obo/HP_0200029	Vasculitis in the skin		
http://purl.obolibrary.org/obo/HP_0007432	Intermittent generalized erythematous papular rash	http://purl.obolibrary.org/obo/HP_0200034	Papule		
http://purl.obolibrary.org/obo/HP_0200059	Metastatic angiosarcoma	http://purl.obolibrary.org/obo/HP_0200058	Angiosarcoma		
http://purl.obolibrary.org/obo/HP_0200107	Shortened inner dynein arms	http://purl.obolibrary.org/obo/HP_0200106	Absent/shortened dynein arms		
http://purl.obolibrary.org/obo/HP_0200108	Shortened outer dynein arms	http://purl.obolibrary.org/obo/HP_0200106	Absent/shortened dynein arms		
http://purl.obolibrary.org/obo/HP_0200109	Absent/shortened outer dynein arms	http://purl.obolibrary.org/obo/HP_0200106	Absent/shortened dynein arms		
http://purl.obolibrary.org/obo/UBERON_0005205	lamina propria of vagina	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		
http://purl.obolibrary.org/obo/UBERON_0036553	wall of synovial tendon sheath	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		
http://purl.obolibrary.org/obo/UBERON_0014848	tendon of quadriceps femoris	http://purl.obolibrary.org/obo/UBERON_0003589	hindlimb connective tissue		
http://purl.obolibrary.org/obo/UBERON_0035074	duct of apocrine sweat gland	http://purl.obolibrary.org/obo/UBERON_0000058	duct		
http://purl.obolibrary.org/obo/UBERON_0035050	excretory duct	http://purl.obolibrary.org/obo/UBERON_0000058	duct		
http://purl.obolibrary.org/obo/UBERON_0036441	wall of fallopian tube	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		
http://purl.obolibrary.org/obo/UBERON_0036521	wall of urethra	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		
http://purl.obolibrary.org/obo/UBERON_0036523	wall of vagina	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		
http://purl.obolibrary.org/obo/UBERON_0036658	wall of central canal of spinal cord	http://purl.obolibrary.org/obo/UBERON_0005358	ventricle of nervous system		
http://purl.obolibrary.org/obo/UBERON_0036661	wall of ventricular system of brain	http://purl.obolibrary.org/obo/UBERON_0005358	ventricle of nervous system		
http://purl.obolibrary.org/obo/UBERON_0036925	wall of eyeball	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		
http://purl.obolibrary.org/obo/UBERON_0036990	wall of pharyngotympanic tube	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		
http://purl.obolibrary.org/obo/UBERON_0037089	wall of orbit	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		
http://purl.obolibrary.org/obo/UBERON_0037191	wall of membranous labyrinth	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		
http://purl.obolibrary.org/obo/UBERON_0037237	wall of lacrimal duct	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		
http://purl.obolibrary.org/obo/UBERON_0035965	wall of blood vessel	http://purl.obolibrary.org/obo/UBERON_0000060	anatomical wall		
http://purl.obolibrary.org/obo/UBERON_0009856	sac	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0018254	skeletal musculature	http://purl.obolibrary.org/obo/UBERON_0000061	anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0009911	lobule	http://purl.obolibrary.org/obo/UBERON_0000063	organ subunit		
http://purl.obolibrary.org/obo/UBERON_0001726	papilla of tongue	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0003978	valve	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0006203	conchal part of pinna	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0010071	layer of tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0010938	muscle belly	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0011741	cardiac valve leaflet	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0013522	subdivision of tube	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0016409	base of glans penis	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		
http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ	http://purl.obolibrary.org/obo/UBERON_0000064	organ part		
http://purl.obolibrary.org/obo/UBERON_0011159	primary subdivision of cranial skeletal system	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		
http://purl.obolibrary.org/obo/UBERON_0012072	palatal part of dermatocranium	http://purl.obolibrary.org/obo/UBERON_0000075	subdivision of skeletal system		
http://purl.obolibrary.org/obo/UBERON_0000112	sexually immature stage	http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage		
http://purl.obolibrary.org/obo/UBERON_0002464	nerve trunk	http://purl.obolibrary.org/obo/UBERON_0000122	neuron projection bundle		
http://purl.obolibrary.org/obo/UBERON_0036253	orifice of skull	http://purl.obolibrary.org/obo/UBERON_0000161	orifice		
http://purl.obolibrary.org/obo/UBERON_0039175	subarachnoid space of brain	http://purl.obolibrary.org/obo/UBERON_0000315	subarachnoid space		
http://purl.obolibrary.org/obo/UBERON_0039176	subarachnoid space of spinal cord	http://purl.obolibrary.org/obo/UBERON_0000315	subarachnoid space		
http://purl.obolibrary.org/obo/UBERON_0019042	reproductive system mucosa	http://purl.obolibrary.org/obo/UBERON_0005156	reproductive structure		
http://purl.obolibrary.org/obo/UBERON_0001978	parenchyma of pancreas	http://purl.obolibrary.org/obo/UBERON_0000353	parenchyma		
http://purl.obolibrary.org/obo/UBERON_0019190	mucous gland of lung	http://purl.obolibrary.org/obo/UBERON_0036225	respiratory system gland		
http://purl.obolibrary.org/obo/UBERON_0036328	wall of coronary artery	http://purl.obolibrary.org/obo/UBERON_0037144	wall of heart		
http://purl.obolibrary.org/obo/UBERON_0036351	wall of brachiocephalic artery	http://purl.obolibrary.org/obo/UBERON_0000415	artery wall		
http://purl.obolibrary.org/obo/UBERON_0036352	wall of subclavian artery	http://purl.obolibrary.org/obo/UBERON_0000415	artery wall		
http://purl.obolibrary.org/obo/UBERON_0036422	wall of pulmonary artery	http://purl.obolibrary.org/obo/UBERON_0000415	artery wall		
http://purl.obolibrary.org/obo/UBERON_0037094	wall of common carotid artery	http://purl.obolibrary.org/obo/UBERON_0000415	artery wall		
http://purl.obolibrary.org/obo/UBERON_0005945	neurocranial trabecula	http://purl.obolibrary.org/obo/UBERON_0003932	cartilage element of chondrocranium		
http://purl.obolibrary.org/obo/UBERON_0001971	gastric juice	http://purl.obolibrary.org/obo/UBERON_0000456	secretion of exocrine gland		
http://purl.obolibrary.org/obo/UBERON_0010061	lumen of nasopharynx	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		
http://purl.obolibrary.org/obo/UBERON_0012466	extraembryonic cavity	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		
http://purl.obolibrary.org/obo/UBERON_0014466	subarachnoid fissure	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		
http://purl.obolibrary.org/obo/UBERON_0034905	gland lumen	http://purl.obolibrary.org/obo/UBERON_0000464	anatomical space		
http://purl.obolibrary.org/obo/UBERON_0000153	anterior region of body	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		
http://purl.obolibrary.org/obo/UBERON_0000154	posterior region of body	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		
http://purl.obolibrary.org/obo/UBERON_0001444	subdivision of head	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		
http://purl.obolibrary.org/obo/UBERON_0006333	snout	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		
http://purl.obolibrary.org/obo/UBERON_0009569	subdivision of trunk	http://purl.obolibrary.org/obo/UBERON_0000475	organism subdivision		
http://purl.obolibrary.org/obo/UBERON_0011860	collection of collagen fibrils	http://purl.obolibrary.org/obo/UBERON_0000476	acellular anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0003254	amniotic ectoderm	http://purl.obolibrary.org/obo/UBERON_0005292	extraembryonic tissue		
http://purl.obolibrary.org/obo/UBERON_0005497	non-neural ectoderm	http://purl.obolibrary.org/obo/UBERON_0004121	ectoderm-derived structure		
http://purl.obolibrary.org/obo/UBERON_0010536	nephron progenitor	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		
http://purl.obolibrary.org/obo/UBERON_0015757	heterogeneous tissue	http://purl.obolibrary.org/obo/UBERON_0000479	tissue		
http://purl.obolibrary.org/obo/UBERON_0012361	internal anal region	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		
http://purl.obolibrary.org/obo/UBERON_0012469	external anal region	http://purl.obolibrary.org/obo/UBERON_0000481	multi-tissue structure		
http://purl.obolibrary.org/obo/UBERON_0019304	sensory organ epithelium	http://purl.obolibrary.org/obo/UBERON_0000483	epithelium		
http://purl.obolibrary.org/obo/UBERON_0006930	glandular cuboidal epithelium	http://purl.obolibrary.org/obo/UBERON_0006799	glandular epithelium		
http://purl.obolibrary.org/obo/UBERON_0011272	embryonic skin basal layer	http://purl.obolibrary.org/obo/UBERON_0000490	unilaminar epithelium		
http://purl.obolibrary.org/obo/UBERON_0011592	future upper lip	http://purl.obolibrary.org/obo/UBERON_0003235	epithelium of upper jaw		
http://purl.obolibrary.org/obo/UBERON_0011596	future lower lip	http://purl.obolibrary.org/obo/UBERON_0003236	epithelium of lower jaw		
http://purl.obolibrary.org/obo/UBERON_0012313	1st arch maxillary ectoderm	http://purl.obolibrary.org/obo/UBERON_0015833	foregut epithelium		
http://purl.obolibrary.org/obo/UBERON_0004468	set of muscles of vertebral column	http://purl.obolibrary.org/obo/UBERON_0001015	musculature		
http://purl.obolibrary.org/obo/UBERON_0034729	sympathetic nerve	http://purl.obolibrary.org/obo/UBERON_0001021	nerve		
http://purl.obolibrary.org/obo/UBERON_0006224	elbow joint primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0006227	ethmoid bone primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0006236	tetrapod frontal bone primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0006244	hip joint primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0006256	knee joint primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0006274	tetrapod parietal bone primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0008801	parotid gland primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0008947	respiratory primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0010375	pancreas dorsal primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0010376	pancreas ventral primordium	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0010751	squamous part of temporal bone primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0011130	temporomandibular joint primordium	http://purl.obolibrary.org/obo/UBERON_0001048	primordium		
http://purl.obolibrary.org/obo/UBERON_0004622	sacral vertebra 1	http://purl.obolibrary.org/obo/UBERON_0001094	sacral vertebra		
http://purl.obolibrary.org/obo/UBERON_0018550	secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0007775	secondary tooth		
http://purl.obolibrary.org/obo/UBERON_0000219	vertebral foramen of atlas	http://purl.obolibrary.org/obo/UBERON_0005744	bone foramen		
http://purl.obolibrary.org/obo/UBERON_0036362	wall of anal canal	http://purl.obolibrary.org/obo/UBERON_0001169	wall of large intestine		
http://purl.obolibrary.org/obo/UBERON_0022357	mesentery of ileum	http://purl.obolibrary.org/obo/UBERON_0001170	mesentery of small intestine		
http://purl.obolibrary.org/obo/UBERON_0022281	epithelium of crypt of Lieberkuhn of large intestine	http://purl.obolibrary.org/obo/UBERON_0011184	epithelium of crypt of Lieberkuhn		
http://purl.obolibrary.org/obo/UBERON_0019241	pedal digit 1 or 5	http://purl.obolibrary.org/obo/UBERON_0019221	digit 1 or 5		
http://purl.obolibrary.org/obo/UBERON_0019242	pedal digit 2, 3 or 4	http://purl.obolibrary.org/obo/UBERON_0019222	digit 2, 3 or 4		
http://purl.obolibrary.org/obo/UBERON_0001425	pectoral lymphatic vessel	http://purl.obolibrary.org/obo/UBERON_0001473	lymphatic vessel		
http://purl.obolibrary.org/obo/UBERON_0008202	bone of hip region	http://purl.obolibrary.org/obo/UBERON_0001474	bone element		
http://purl.obolibrary.org/obo/UBERON_0001430	distal carpal bone 1	http://purl.obolibrary.org/obo/UBERON_0015084	distal carpal bone 1 endochondral element		
http://purl.obolibrary.org/obo/UBERON_0001431	distal carpal bone 2	http://purl.obolibrary.org/obo/UBERON_0015087	distal carpal bone 2 endochondral element		
http://purl.obolibrary.org/obo/UBERON_0001432	distal carpal bone 3	http://purl.obolibrary.org/obo/UBERON_0015090	distal carpal bone 3 endochondral element		
http://purl.obolibrary.org/obo/UBERON_0001433	distal carpal bone 4	http://purl.obolibrary.org/obo/UBERON_0015093	distal carpal bone 4 endochondral element		
http://purl.obolibrary.org/obo/UBERON_0002988	first dorsal interosseous of manus	http://purl.obolibrary.org/obo/UBERON_0001503	dorsal interosseous of manus		
http://purl.obolibrary.org/obo/UBERON_0006328	laryngeal intrinsic muscle	http://purl.obolibrary.org/obo/UBERON_0001568	muscle of larynx		
http://purl.obolibrary.org/obo/UBERON_0019254	upper eyelash	http://purl.obolibrary.org/obo/UBERON_0010171	strand of hair of face		
http://purl.obolibrary.org/obo/UBERON_0019255	lower eyelash	http://purl.obolibrary.org/obo/UBERON_0010171	strand of hair of face		
http://purl.obolibrary.org/obo/UBERON_0012175	acoustico-facial VII-VIII ganglion complex	http://purl.obolibrary.org/obo/UBERON_0010313	neural crest-derived structure		
http://purl.obolibrary.org/obo/UBERON_0013498	vestibulo-cochlear VIII ganglion complex	http://purl.obolibrary.org/obo/UBERON_0001714	cranial ganglion		
http://purl.obolibrary.org/obo/UBERON_0001730	extrinsic ligament of larynx	http://purl.obolibrary.org/obo/UBERON_0001743	ligament of larynx		
http://purl.obolibrary.org/obo/UBERON_0006325	laryngeal intrinsic ligament	http://purl.obolibrary.org/obo/UBERON_0001743	ligament of larynx		
http://purl.obolibrary.org/obo/UBERON_0000444	lymphoid follicle	http://purl.obolibrary.org/obo/UBERON_0001744	lymphoid tissue		
http://purl.obolibrary.org/obo/UBERON_0012069	epithelium-associated lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0001744	lymphoid tissue		
http://purl.obolibrary.org/obo/UBERON_0015844	molar dental papilla	http://purl.obolibrary.org/obo/UBERON_0001763	odontogenic papilla		
http://purl.obolibrary.org/obo/UBERON_0007619	limiting membrane of retina	http://purl.obolibrary.org/obo/UBERON_0001781	layer of retina		
http://purl.obolibrary.org/obo/UBERON_0001809	enteric ganglion	http://purl.obolibrary.org/obo/UBERON_0001808	parasympathetic ganglion		
http://purl.obolibrary.org/obo/UBERON_0022280	epithelium of crypt of Lieberkuhn of small intestine	http://purl.obolibrary.org/obo/UBERON_0011184	epithelium of crypt of Lieberkuhn		
http://purl.obolibrary.org/obo/UBERON_0019189	carotid artery endothelium	http://purl.obolibrary.org/obo/UBERON_0001917	endothelium of artery		
http://purl.obolibrary.org/obo/UBERON_0019196	iliac artery endothelium	http://purl.obolibrary.org/obo/UBERON_0001917	endothelium of artery		
http://purl.obolibrary.org/obo/UBERON_0005844	spinal cord segment	http://purl.obolibrary.org/obo/UBERON_0001948	regional part of spinal cord		
http://purl.obolibrary.org/obo/UBERON_0022292	splenic arteriole	http://purl.obolibrary.org/obo/UBERON_0003497	abdomen blood vessel		
http://purl.obolibrary.org/obo/UBERON_0036269	penis blood vessel	http://purl.obolibrary.org/obo/UBERON_0001981	blood vessel		
http://purl.obolibrary.org/obo/UBERON_0010059	hypoglossal cord	http://purl.obolibrary.org/obo/UBERON_0002036	striated muscle tissue		
http://purl.obolibrary.org/obo/UBERON_2001073	axial vasculature	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		
http://purl.obolibrary.org/obo/UBERON_0036302	vasculature of central nervous system plus retina	http://purl.obolibrary.org/obo/UBERON_0002049	vasculature		
http://purl.obolibrary.org/obo/UBERON_0003076	posterior neural tube	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0003080	anterior neural tube	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0005092	right horn of sinus venosus	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0006218	common atrial chamber	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0006232	facio-acoustic VII-VIII preganglion complex	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0006260	lingual swellings	http://purl.obolibrary.org/obo/UBERON_0010188	protuberance		
http://purl.obolibrary.org/obo/UBERON_0007237	1st arch mandibular component	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0007238	1st arch maxillary component	http://purl.obolibrary.org/obo/UBERON_0002050	embryonic structure		
http://purl.obolibrary.org/obo/UBERON_0010316	germ layer / neural crest	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		
http://purl.obolibrary.org/obo/UBERON_0010963	trunk and cervical myotome group	http://purl.obolibrary.org/obo/UBERON_0003082	myotome		
http://purl.obolibrary.org/obo/UBERON_0009664	gut mesentery	http://purl.obolibrary.org/obo/UBERON_0002095	mesentery		
http://purl.obolibrary.org/obo/UBERON_0030276	lumbar spinal cord ventral horn	http://purl.obolibrary.org/obo/UBERON_0002257	ventral horn of spinal cord		
http://purl.obolibrary.org/obo/UBERON_0032748	sacral spinal cord ventral horn	http://purl.obolibrary.org/obo/UBERON_0002257	ventral horn of spinal cord		
http://purl.obolibrary.org/obo/UBERON_0034730	olfactory tract linking bulb to ipsilateral dorsal telencephalon	http://purl.obolibrary.org/obo/UBERON_0002265	olfactory tract		
http://purl.obolibrary.org/obo/UBERON_2000238	olfactory tract linking bulb to ipsilateral ventral telencephalon	http://purl.obolibrary.org/obo/UBERON_0002265	olfactory tract		
http://purl.obolibrary.org/obo/UBERON_0005367	hippocampus granule cell layer	http://purl.obolibrary.org/obo/UBERON_0002305	layer of hippocampus		
http://purl.obolibrary.org/obo/UBERON_0029503	sacral spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0002315	gray matter of spinal cord		
http://purl.obolibrary.org/obo/UBERON_0029636	lumbar spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0002315	gray matter of spinal cord		
http://purl.obolibrary.org/obo/UBERON_0007417	peduncle of neuraxis	http://purl.obolibrary.org/obo/UBERON_0002316	white matter		
http://purl.obolibrary.org/obo/UBERON_0014932	periventricular white matter	http://purl.obolibrary.org/obo/UBERON_0002316	white matter		
http://purl.obolibrary.org/obo/UBERON_0026246	sacral spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0002318	white matter of spinal cord		
http://purl.obolibrary.org/obo/UBERON_0026386	lumbar spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0002318	white matter of spinal cord		
http://purl.obolibrary.org/obo/UBERON_0009708	dorsal pancreas	http://purl.obolibrary.org/obo/UBERON_0005177	trunk region element		
http://purl.obolibrary.org/obo/UBERON_0009709	ventral pancreas	http://purl.obolibrary.org/obo/UBERON_0005177	trunk region element		
http://purl.obolibrary.org/obo/UBERON_0011648	jaw muscle	http://purl.obolibrary.org/obo/UBERON_0002376	cranial muscle		
http://purl.obolibrary.org/obo/UBERON_0015789	cranial or facial muscle	http://purl.obolibrary.org/obo/UBERON_0002376	cranial muscle		
http://purl.obolibrary.org/obo/UBERON_0019206	tongue papilla epithelium	http://purl.obolibrary.org/obo/UBERON_0003357	epithelium of tongue		
http://purl.obolibrary.org/obo/UBERON_0016527	white matter of cerebral lobe	http://purl.obolibrary.org/obo/UBERON_0002437	cerebral hemisphere white matter		
http://purl.obolibrary.org/obo/UBERON_0006355	superior vesical vein	http://purl.obolibrary.org/obo/UBERON_0002460	vesical vein		
http://purl.obolibrary.org/obo/UBERON_0002004	trunk of sciatic nerve	http://purl.obolibrary.org/obo/UBERON_0002464	nerve trunk		
http://purl.obolibrary.org/obo/UBERON_0002442	axillary nerve trunk	http://purl.obolibrary.org/obo/UBERON_0002464	nerve trunk		
http://purl.obolibrary.org/obo/UBERON_0016413	medullary cavity of long bone	http://purl.obolibrary.org/obo/UBERON_0002484	bone marrow cavity		
http://purl.obolibrary.org/obo/UBERON_0015860	visceral abdominal lymph node	http://purl.obolibrary.org/obo/UBERON_0002507	abdominal lymph node		
http://purl.obolibrary.org/obo/UBERON_0008837	palmar/plantar part of autopod	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		
http://purl.obolibrary.org/obo/UBERON_0012139	segment of autopod	http://purl.obolibrary.org/obo/UBERON_0002529	limb segment		
http://purl.obolibrary.org/obo/UBERON_0002558	organ cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		
http://purl.obolibrary.org/obo/UBERON_0005606	hyaloid cavity	http://purl.obolibrary.org/obo/UBERON_0012467	enclosed anatomical space		
http://purl.obolibrary.org/obo/UBERON_0011565	lumen of gastrointestinal system	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		
http://purl.obolibrary.org/obo/UBERON_0035763	cavity of cardiac chamber	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		
http://purl.obolibrary.org/obo/UBERON_0035809	serous cavity	http://purl.obolibrary.org/obo/UBERON_0002553	anatomical cavity		
http://purl.obolibrary.org/obo/UBERON_0004703	dorsal thalamus	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		
http://purl.obolibrary.org/obo/UBERON_0007709	superior cerebellar peduncle of pons	http://purl.obolibrary.org/obo/UBERON_0002616	regional part of brain		
http://purl.obolibrary.org/obo/UBERON_0005502	rhombomere roof plate	http://purl.obolibrary.org/obo/UBERON_0003054	roof plate		
http://purl.obolibrary.org/obo/UBERON_0005113	metanephric cortex mesenchyme	http://purl.obolibrary.org/obo/UBERON_0004120	mesoderm-derived structure		
http://purl.obolibrary.org/obo/UBERON_0006210	body-wall mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		
http://purl.obolibrary.org/obo/UBERON_0036073	respiratory primordium mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003104	mesenchyme		
http://purl.obolibrary.org/obo/UBERON_0007690	early pharyngeal endoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		
http://purl.obolibrary.org/obo/UBERON_0013156	1st arch mandibular endoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		
http://purl.obolibrary.org/obo/UBERON_0016944	upper premolar tooth	http://purl.obolibrary.org/obo/UBERON_0007120	premolar tooth		
http://purl.obolibrary.org/obo/UBERON_0018613	secondary upper tooth	http://purl.obolibrary.org/obo/UBERON_0007775	secondary tooth		
http://purl.obolibrary.org/obo/UBERON_0018616	primary upper tooth	http://purl.obolibrary.org/obo/UBERON_0007115	deciduous tooth		
http://purl.obolibrary.org/obo/UBERON_0018621	upper canine tooth	http://purl.obolibrary.org/obo/UBERON_0003674	cuspid		
http://purl.obolibrary.org/obo/UBERON_0016943	lower premolar tooth	http://purl.obolibrary.org/obo/UBERON_0007120	premolar tooth		
http://purl.obolibrary.org/obo/UBERON_0018614	permanent lower tooth	http://purl.obolibrary.org/obo/UBERON_0007775	secondary tooth		
http://purl.obolibrary.org/obo/UBERON_0018617	primary lower tooth	http://purl.obolibrary.org/obo/UBERON_0007115	deciduous tooth		
http://purl.obolibrary.org/obo/UBERON_0018622	lower canine tooth	http://purl.obolibrary.org/obo/UBERON_0003674	cuspid		
http://purl.obolibrary.org/obo/UBERON_0006230	extrinsic ocular pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0006292	shoulder joint primordium	http://purl.obolibrary.org/obo/UBERON_0005856	developing mesenchymal condensation		
http://purl.obolibrary.org/obo/UBERON_0005667	connecting stalk mesoderm	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		
http://purl.obolibrary.org/obo/UBERON_0015851	upper right incisor tusk	http://purl.obolibrary.org/obo/UBERON_0015848	incisor tusk		
http://purl.obolibrary.org/obo/UBERON_0019253	upper secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018613	secondary upper tooth		
http://purl.obolibrary.org/obo/UBERON_0018623	lower secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018614	permanent lower tooth		
http://purl.obolibrary.org/obo/UBERON_0017635	paired venous dural sinus	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0019263	gray matter of hindbrain	http://purl.obolibrary.org/obo/UBERON_0003528	brain gray matter		
http://purl.obolibrary.org/obo/UBERON_0019264	gray matter of forebrain	http://purl.obolibrary.org/obo/UBERON_0003528	brain gray matter		
http://purl.obolibrary.org/obo/UBERON_0019267	gray matter of midbrain	http://purl.obolibrary.org/obo/UBERON_0003528	brain gray matter		
http://purl.obolibrary.org/obo/UBERON_0009644	trachea non-cartilage connective tissue	http://purl.obolibrary.org/obo/UBERON_0003571	trachea connective tissue		
http://purl.obolibrary.org/obo/UBERON_0013616	primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0007115	deciduous tooth		
http://purl.obolibrary.org/obo/UBERON_0013618	secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0007775	secondary tooth		
http://purl.obolibrary.org/obo/UBERON_0011144	adductor muscle of hip	http://purl.obolibrary.org/obo/UBERON_0011145	adductor muscle		
http://purl.obolibrary.org/obo/UBERON_0018583	primary canine tooth	http://purl.obolibrary.org/obo/UBERON_0007115	deciduous tooth		
http://purl.obolibrary.org/obo/UBERON_0018584	secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0007775	secondary tooth		
http://purl.obolibrary.org/obo/UBERON_0006720	pterygoid muscle	http://purl.obolibrary.org/obo/UBERON_0003681	masticatory muscle		
http://purl.obolibrary.org/obo/UBERON_0036343	wall of gallbladder	http://purl.obolibrary.org/obo/UBERON_0003697	abdominal wall		
http://purl.obolibrary.org/obo/UBERON_0011766	left recurrent laryngeal nerve	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0011767	right recurrent laryngeal nerve	http://purl.obolibrary.org/obo/UBERON_0015212	lateral structure		
http://purl.obolibrary.org/obo/UBERON_0015839	molar epithelium	http://purl.obolibrary.org/obo/UBERON_0003843	dental epithelium		
http://purl.obolibrary.org/obo/UBERON_0010687	pedal digit metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015036	pedal digit metatarsal endochondral element		
http://purl.obolibrary.org/obo/UBERON_0006304	future trigeminal ganglion	http://purl.obolibrary.org/obo/UBERON_0003869	presumptive ganglion		
http://purl.obolibrary.org/obo/UBERON_0001746	capsule of thyroid gland	http://purl.obolibrary.org/obo/UBERON_0003893	capsule		
http://purl.obolibrary.org/obo/UBERON_0010894	keratinous tooth	http://purl.obolibrary.org/obo/UBERON_0003913	tooth-like structure		
http://purl.obolibrary.org/obo/UBERON_0010062	pharyngotympanic tube epithelium	http://purl.obolibrary.org/obo/UBERON_0015813	middle ear epithelium		
http://purl.obolibrary.org/obo/UBERON_0010065	auditory meatus epithelium	http://purl.obolibrary.org/obo/UBERON_0015814	outer ear epithelium		
http://purl.obolibrary.org/obo/UBERON_0034969	epithelial layer of duct	http://purl.obolibrary.org/obo/UBERON_0003914	epithelial tube		
http://purl.obolibrary.org/obo/UBERON_0035037	jaw epithelium	http://purl.obolibrary.org/obo/UBERON_0003929	digestive tract epithelium		
http://purl.obolibrary.org/obo/UBERON_0022235	peduncle of diencephalon	http://purl.obolibrary.org/obo/UBERON_0007417	peduncle of neuraxis		
http://purl.obolibrary.org/obo/UBERON_0009950	olfactory bulb plexiform layer	http://purl.obolibrary.org/obo/UBERON_0004001	olfactory bulb layer		
http://purl.obolibrary.org/obo/UBERON_0013160	epithalamus ventricular layer	http://purl.obolibrary.org/obo/UBERON_0004060	neural tube ventricular layer		
http://purl.obolibrary.org/obo/UBERON_0034710	spinal cord ventricular layer	http://purl.obolibrary.org/obo/UBERON_0004060	neural tube ventricular layer		
http://purl.obolibrary.org/obo/UBERON_0009580	diencephalon mantle layer	http://purl.obolibrary.org/obo/UBERON_0004061	neural tube mantle layer		
http://purl.obolibrary.org/obo/UBERON_0009581	midbrain mantle layer	http://purl.obolibrary.org/obo/UBERON_0004061	neural tube mantle layer		
http://purl.obolibrary.org/obo/UBERON_0009583	spinal cord mantle layer	http://purl.obolibrary.org/obo/UBERON_0004061	neural tube mantle layer		
http://purl.obolibrary.org/obo/UBERON_0013159	epithalamus mantle layer	http://purl.obolibrary.org/obo/UBERON_0004061	neural tube mantle layer		
http://purl.obolibrary.org/obo/UBERON_0034709	hindbrain marginal layer	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		
http://purl.obolibrary.org/obo/UBERON_0005239	basal plate metencephalon	http://purl.obolibrary.org/obo/UBERON_0004064	neural tube basal plate		
http://purl.obolibrary.org/obo/UBERON_0005728	extraembryonic mesoderm	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		
http://purl.obolibrary.org/obo/UBERON_0010348	hyoid pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0005339	outflow tract pulmonary component	http://purl.obolibrary.org/obo/UBERON_0004145	outflow tract		
http://purl.obolibrary.org/obo/UBERON_0009196	indifferent external genitalia	http://purl.obolibrary.org/obo/UBERON_0004176	external genitalia		
http://purl.obolibrary.org/obo/UBERON_0004912	biliary bud	http://purl.obolibrary.org/obo/UBERON_0009854	digestive tract diverticulum		
http://purl.obolibrary.org/obo/UBERON_0008836	liver bud	http://purl.obolibrary.org/obo/UBERON_0009854	digestive tract diverticulum		
http://purl.obolibrary.org/obo/UBERON_0036072	respiratory primordium epithelium	http://purl.obolibrary.org/obo/UBERON_0015833	foregut epithelium		
http://purl.obolibrary.org/obo/UBERON_0011222	intra-ocular muscle	http://purl.obolibrary.org/obo/UBERON_0004277	eye muscle		
http://purl.obolibrary.org/obo/UBERON_0034902	sacral sympathetic nerve trunk	http://purl.obolibrary.org/obo/UBERON_0004295	sympathetic nerve trunk		
http://purl.obolibrary.org/obo/UBERON_0012416	respiratory system arterial smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004695	arterial system smooth muscle		
http://purl.obolibrary.org/obo/UBERON_0014886	distal epiphysis of distal phalanx of manual digit	http://purl.obolibrary.org/obo/UBERON_0014887	distal epiphysis of distal phalanx of digit		
http://purl.obolibrary.org/obo/UBERON_0013121	proximal epiphysis of phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0011973	epiphysis of phalanx of pes		
http://purl.obolibrary.org/obo/UBERON_0013122	distal epiphysis of phalanx of pes	http://purl.obolibrary.org/obo/UBERON_0011973	epiphysis of phalanx of pes		
http://purl.obolibrary.org/obo/UBERON_0018649	cardiac muscle tissue of ventricle	http://purl.obolibrary.org/obo/UBERON_0004493	cardiac muscle tissue of myocardium		
http://purl.obolibrary.org/obo/UBERON_2001053	future internal carotid artery	http://purl.obolibrary.org/obo/UBERON_0004573	systemic artery		
http://purl.obolibrary.org/obo/UBERON_0008339	microvascular endothelium	http://purl.obolibrary.org/obo/UBERON_0004638	blood vessel endothelium		
http://purl.obolibrary.org/obo/UBERON_0012276	endometrium glandular epithelium	http://purl.obolibrary.org/obo/UBERON_0007589	ciliated columnar oviduct epithelium		
http://purl.obolibrary.org/obo/UBERON_0004919	external urethral sphincter	http://purl.obolibrary.org/obo/UBERON_0004917	urethral sphincter		
http://purl.obolibrary.org/obo/UBERON_0000158	membranous layer	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		
http://purl.obolibrary.org/obo/UBERON_0010291	layer of sclera	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		
http://purl.obolibrary.org/obo/UBERON_0011234	fibrous membrane of synovial tendon sheath	http://purl.obolibrary.org/obo/UBERON_0004923	organ component layer		
http://purl.obolibrary.org/obo/UBERON_0018673	neck of fibula	http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element		
http://purl.obolibrary.org/obo/UBERON_4200172	neck of humerus	http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element		
http://purl.obolibrary.org/obo/UBERON_0006652	muscular layer of vagina	http://purl.obolibrary.org/obo/UBERON_0006660	muscular coat		
http://purl.obolibrary.org/obo/UBERON_0015843	molar enamel organ	http://purl.obolibrary.org/obo/UBERON_0005176	tooth enamel organ		
http://purl.obolibrary.org/obo/UBERON_0015410	heart plus pericardium	http://purl.obolibrary.org/obo/UBERON_0005178	thoracic cavity element		
http://purl.obolibrary.org/obo/UBERON_0010189	right atrium venous valve	http://purl.obolibrary.org/obo/UBERON_0006675	venous valve		
http://purl.obolibrary.org/obo/UBERON_0009920	optic neural crest	http://purl.obolibrary.org/obo/UBERON_0007530	migrating mesenchyme population		
http://purl.obolibrary.org/obo/UBERON_0006295	sternebral bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0005866	pre-cartilage condensation		
http://purl.obolibrary.org/obo/UBERON_0009618	trunk paraxial mesoderm	http://purl.obolibrary.org/obo/UBERON_0005256	trunk mesenchyme		
http://purl.obolibrary.org/obo/UBERON_0009722	entire pharyngeal arch endoderm	http://purl.obolibrary.org/obo/UBERON_0015833	foregut epithelium		
http://purl.obolibrary.org/obo/UBERON_0009881	anterior lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0005291	embryonic tissue		
http://purl.obolibrary.org/obo/UBERON_0009145	pharyngeal region of foregut	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0010531	metanephros induced blastemal cells	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0011757	differentiated genital tubercle	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0013238	future glans	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0014950	layer of developing cerebral cortex	http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0008878	palmar part of manus	http://purl.obolibrary.org/obo/UBERON_0008837	palmar/plantar part of autopod		
http://purl.obolibrary.org/obo/UBERON_0001889	trunk of phrenic nerve	http://purl.obolibrary.org/obo/UBERON_0005476	spinal nerve trunk		
http://purl.obolibrary.org/obo/UBERON_0002327	trunk of intercostal nerve	http://purl.obolibrary.org/obo/UBERON_0005476	spinal nerve trunk		
http://purl.obolibrary.org/obo/UBERON_0022248	cerebral nerve fasciculus	http://purl.obolibrary.org/obo/UBERON_0005838	fasciculus of brain		
http://purl.obolibrary.org/obo/UBERON_0002792	lumbar spinal cord	http://purl.obolibrary.org/obo/UBERON_0005844	spinal cord segment		
http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation	http://purl.obolibrary.org/obo/UBERON_0005856	developing mesenchymal condensation		
http://purl.obolibrary.org/obo/UBERON_0006219	deltoid pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0010929	stapedius pre-muscle condensation	http://purl.obolibrary.org/obo/UBERON_0009506	mesenchyme of middle ear		
http://purl.obolibrary.org/obo/UBERON_0010935	tensor tympani pre-muscle condensation	http://purl.obolibrary.org/obo/UBERON_0009506	mesenchyme of middle ear		
http://purl.obolibrary.org/obo/UBERON_0010955	trapezius pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0010258	mesenchyme from rhombencephalic neural crest		
http://purl.obolibrary.org/obo/UBERON_0010962	extensor pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0010970	intercostal pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_8450004	intercostal element		
http://purl.obolibrary.org/obo/UBERON_0010975	external oblique pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0010977	flexor pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0010982	latissimus dorsi pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0010983	levator scapulae pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0010984	pectoral pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0010986	serratus ventralis pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0011332	extrinsic tongue pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0005865	pre-muscle condensation		
http://purl.obolibrary.org/obo/UBERON_0006263	Meckel's cartilage pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0014387	mesenchyme derived from neural crest		
http://purl.obolibrary.org/obo/UBERON_0010213	laryngeal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0005866	pre-cartilage condensation		
http://purl.obolibrary.org/obo/UBERON_0010354	Reichert's cartilage pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0014387	mesenchyme derived from neural crest		
http://purl.obolibrary.org/obo/UBERON_0010063	tympanic cavity epithelium	http://purl.obolibrary.org/obo/UBERON_0015813	middle ear epithelium		
http://purl.obolibrary.org/obo/UBERON_0002231	body of rib	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		
http://purl.obolibrary.org/obo/UBERON_0007172	angle of scapula	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		
http://purl.obolibrary.org/obo/UBERON_0010424	distal segment of rib	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		
http://purl.obolibrary.org/obo/UBERON_0014444	pubic ramus	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		
http://purl.obolibrary.org/obo/UBERON_0016412	central part of body of bony vertebral centrum	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		
http://purl.obolibrary.org/obo/UBERON_0016419	bony part of vertebral arch	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		
http://purl.obolibrary.org/obo/UBERON_0017690	internal surface of frontal bone	http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ		
http://purl.obolibrary.org/obo/UBERON_0019294	commissure of telencephalon	http://purl.obolibrary.org/obo/UBERON_0005970	brain commissure		
http://purl.obolibrary.org/obo/UBERON_0006136	unmyelinated nerve fiber	http://purl.obolibrary.org/obo/UBERON_0006134	nerve fiber		
http://purl.obolibrary.org/obo/UBERON_0006532	oblique extraocular muscle	http://purl.obolibrary.org/obo/UBERON_0006531	oculomotor muscle		
http://purl.obolibrary.org/obo/UBERON_0006533	rectus extraocular muscle	http://purl.obolibrary.org/obo/UBERON_0006531	oculomotor muscle		
http://purl.obolibrary.org/obo/UBERON_0005795	embryonic uterus	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0006241	future spinal cord	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0006596	presumptive blood	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0006600	presumptive enteric nervous system	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0007026	presumptive gut	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0009615	midbrain hindbrain boundary neural plate	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0034875	future pituitary gland	http://purl.obolibrary.org/obo/UBERON_0006598	presumptive structure		
http://purl.obolibrary.org/obo/UBERON_0010222	anatomical line between pupils	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		
http://purl.obolibrary.org/obo/UBERON_0010231	anatomical line between outer ears	http://purl.obolibrary.org/obo/UBERON_0006800	anatomical line		
http://purl.obolibrary.org/obo/UBERON_0017269	primary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0007120	premolar tooth		
http://purl.obolibrary.org/obo/UBERON_0017270	secondary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0007775	secondary tooth		
http://purl.obolibrary.org/obo/UBERON_0015128	subepicardial layer of epicardium	http://purl.obolibrary.org/obo/UBERON_0007188	mesothelium of serous pericardium		
http://purl.obolibrary.org/obo/UBERON_0014706	primitive renal collecting duct system	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		
http://purl.obolibrary.org/obo/UBERON_0011921	connecting stalk blood islands	http://purl.obolibrary.org/obo/UBERON_0012275	meso-epithelium		
http://purl.obolibrary.org/obo/UBERON_0010221	laryngeal associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0007524	dense mesenchyme tissue		
http://purl.obolibrary.org/obo/UBERON_0007606	ciliated stratified columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0007602	stratified columnar epithelium		
http://purl.obolibrary.org/obo/UBERON_0014672	distal interphalangeal joint of pedal digit 2	http://purl.obolibrary.org/obo/UBERON_0014677	distal interphalangeal joint of digit 2		
http://purl.obolibrary.org/obo/UBERON_0014674	distal interphalangeal joint of pedal digit 4	http://purl.obolibrary.org/obo/UBERON_0014679	distal interphalangeal joint of digit 4		
http://purl.obolibrary.org/obo/UBERON_0014675	distal interphalangeal joint of pedal digit 5	http://purl.obolibrary.org/obo/UBERON_0014680	distal interphalangeal joint of digit 5		
http://purl.obolibrary.org/obo/UBERON_0014668	distal interphalangeal joint of manual digit 2	http://purl.obolibrary.org/obo/UBERON_0014677	distal interphalangeal joint of digit 2		
http://purl.obolibrary.org/obo/UBERON_0014670	distal interphalangeal joint of manual digit 4	http://purl.obolibrary.org/obo/UBERON_0014679	distal interphalangeal joint of digit 4		
http://purl.obolibrary.org/obo/UBERON_0014671	distal interphalangeal joint of manural digit 5	http://purl.obolibrary.org/obo/UBERON_0014680	distal interphalangeal joint of digit 5		
http://purl.obolibrary.org/obo/UBERON_0016426	proximal interphalangeal joint of little finger	http://purl.obolibrary.org/obo/UBERON_0009767	proximal interphalangeal joint		
http://purl.obolibrary.org/obo/UBERON_0006609	corpus cavernosum	http://purl.obolibrary.org/obo/UBERON_0008324	erectile tissue		
http://purl.obolibrary.org/obo/UBERON_0011320	ligament of temporomandibular joint	http://purl.obolibrary.org/obo/UBERON_0013765	digestive system element		
http://purl.obolibrary.org/obo/UBERON_0011628	early premaxilla	http://purl.obolibrary.org/obo/UBERON_0011597	bone of upper jaw		
http://purl.obolibrary.org/obo/UBERON_0014693	inferior alveolar artery	http://purl.obolibrary.org/obo/UBERON_0009654	alveolar artery		
http://purl.obolibrary.org/obo/UBERON_0036375	wall of right ureter	http://purl.obolibrary.org/obo/UBERON_0009916	wall of ureter		
http://purl.obolibrary.org/obo/UBERON_0036376	wall of left ureter	http://purl.obolibrary.org/obo/UBERON_0009916	wall of ureter		
http://purl.obolibrary.org/obo/UBERON_0013150	future brain vesicle	http://purl.obolibrary.org/obo/UBERON_0010000	multicellular anatomical structure		
http://purl.obolibrary.org/obo/UBERON_0010214	cricoid pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010213	laryngeal pre-cartilage condensation		
http://purl.obolibrary.org/obo/UBERON_0010219	thyroid pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010213	laryngeal pre-cartilage condensation		
http://purl.obolibrary.org/obo/UBERON_0010220	arytenoid pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010213	laryngeal pre-cartilage condensation		
http://purl.obolibrary.org/obo/UBERON_0009638	orbitosphenoid ossification center	http://purl.obolibrary.org/obo/UBERON_0010355	ossification center		
http://purl.obolibrary.org/obo/UBERON_0010528	pneumatic cavity of bone	http://purl.obolibrary.org/obo/UBERON_0010527	cavity of bone organ		
http://purl.obolibrary.org/obo/UBERON_0010700	phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015023	phalanx endochondral element		
http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element	http://purl.obolibrary.org/obo/UBERON_0015064	autopod cartilage		
http://purl.obolibrary.org/obo/UBERON_0010698	manual digit metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0015042	manual digit metacarpus endochondral element		
http://purl.obolibrary.org/obo/UBERON_0035129	pes cartilage element	http://purl.obolibrary.org/obo/UBERON_0015064	autopod cartilage		
http://purl.obolibrary.org/obo/UBERON_0011152	dorsal hyoid arch skeleton	http://purl.obolibrary.org/obo/UBERON_0010912	subdivision of skeleton		
http://purl.obolibrary.org/obo/UBERON_0014530	white matter lamina of neuraxis	http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer		
http://purl.obolibrary.org/obo/UBERON_0016550	spinal cord column	http://purl.obolibrary.org/obo/UBERON_0011215	central nervous system cell part cluster		
http://purl.obolibrary.org/obo/UBERON_0016570	lamina of gray matter of spinal cord	http://purl.obolibrary.org/obo/UBERON_0022303	nervous system cell part layer		
http://purl.obolibrary.org/obo/UBERON_0006525	left lung alveolar system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		
http://purl.obolibrary.org/obo/UBERON_0006526	right lung alveolar system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		
http://purl.obolibrary.org/obo/UBERON_0010191	aortic system	http://purl.obolibrary.org/obo/UBERON_0011216	organ system subdivision		
http://purl.obolibrary.org/obo/UBERON_0001606	muscle of iris	http://purl.obolibrary.org/obo/UBERON_0011222	intra-ocular muscle		
http://purl.obolibrary.org/obo/UBERON_0011344	lateral surface of mandible	http://purl.obolibrary.org/obo/UBERON_0011342	surface of mandible		
http://purl.obolibrary.org/obo/UBERON_0025261	thalamic fiber tract	http://purl.obolibrary.org/obo/UBERON_0011591	tract of diencephalon		
http://purl.obolibrary.org/obo/UBERON_0005434	cervical region	http://purl.obolibrary.org/obo/UBERON_0011676	subdivision of organism along main body axis		
http://purl.obolibrary.org/obo/UBERON_0018405	inferior alveolar nerve	http://purl.obolibrary.org/obo/UBERON_0011779	nerve of head region		
http://purl.obolibrary.org/obo/UBERON_0011824	fibrous connective tissue	http://purl.obolibrary.org/obo/UBERON_0011822	dense irregular connective tissue		
http://purl.obolibrary.org/obo/UBERON_0018135	fibrocollagenous connective tissue	http://purl.obolibrary.org/obo/UBERON_0011824	fibrous connective tissue		
http://purl.obolibrary.org/obo/UBERON_0014876	distal epiphysis of distal phalanx of pedal digit	http://purl.obolibrary.org/obo/UBERON_0014887	distal epiphysis of distal phalanx of digit		
http://purl.obolibrary.org/obo/UBERON_0009292	embryonic nasal process	http://purl.obolibrary.org/obo/UBERON_0012314	embryonic facial prominence		
http://purl.obolibrary.org/obo/UBERON_0012485	cloacal villus	http://purl.obolibrary.org/obo/UBERON_0012423	layer of microvilli		
http://purl.obolibrary.org/obo/UBERON_0009676	early telencephalic vesicle	http://purl.obolibrary.org/obo/UBERON_0013150	future brain vesicle		
http://purl.obolibrary.org/obo/UBERON_0013147	early mesencephalic vesicle	http://purl.obolibrary.org/obo/UBERON_0013150	future brain vesicle		
http://purl.obolibrary.org/obo/UBERON_0013148	early midbrain vesicle	http://purl.obolibrary.org/obo/UBERON_0013150	future brain vesicle		
http://purl.obolibrary.org/obo/UBERON_0013149	hindbrain vesicle	http://purl.obolibrary.org/obo/UBERON_0013150	future brain vesicle		
http://purl.obolibrary.org/obo/UBERON_0018643	deciduous molar tooth 2	http://purl.obolibrary.org/obo/UBERON_0018606	molar tooth 2		
http://purl.obolibrary.org/obo/UBERON_0018644	deciduous molar tooth 1	http://purl.obolibrary.org/obo/UBERON_0018376	molar tooth 1		
http://purl.obolibrary.org/obo/UBERON_0018588	upper first primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018644	deciduous molar tooth 1		
http://purl.obolibrary.org/obo/UBERON_0018599	upper second primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018643	deciduous molar tooth 2		
http://purl.obolibrary.org/obo/UBERON_0018607	permanent molar tooth 2	http://purl.obolibrary.org/obo/UBERON_0018606	molar tooth 2		
http://purl.obolibrary.org/obo/UBERON_0018608	permanent molar tooth 1	http://purl.obolibrary.org/obo/UBERON_0018376	molar tooth 1		
http://purl.obolibrary.org/obo/UBERON_0018575	upper first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018608	permanent molar tooth 1		
http://purl.obolibrary.org/obo/UBERON_0018576	upper second secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018607	permanent molar tooth 2		
http://purl.obolibrary.org/obo/UBERON_0018589	lower first primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018644	deciduous molar tooth 1		
http://purl.obolibrary.org/obo/UBERON_0018600	lower second primary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018643	deciduous molar tooth 2		
http://purl.obolibrary.org/obo/UBERON_0018578	lower first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018608	permanent molar tooth 1		
http://purl.obolibrary.org/obo/UBERON_0018579	lower second secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018607	permanent molar tooth 2		
http://purl.obolibrary.org/obo/UBERON_0014531	white matter lamina of diencephalon	http://purl.obolibrary.org/obo/UBERON_0014530	white matter lamina of neuraxis		
http://purl.obolibrary.org/obo/UBERON_0014532	white matter lamina of cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0014530	white matter lamina of neuraxis		
http://purl.obolibrary.org/obo/UBERON_0035053	interlobular duct of salivary gland	http://purl.obolibrary.org/obo/UBERON_0035049	excretory duct of salivary gland		
http://purl.obolibrary.org/obo/UBERON_0019292	white matter of pons	http://purl.obolibrary.org/obo/UBERON_0019291	white matter of metencephalon		
http://purl.obolibrary.org/obo/UBERON_0010701	phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0015064	autopod cartilage		
http://purl.obolibrary.org/obo/UBERON_0010697	pedal digit metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0035129	pes cartilage element		
http://purl.obolibrary.org/obo/UBERON_0010699	manual digit metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0035128	manus cartilage element		
http://purl.obolibrary.org/obo/UBERON_0015084	distal carpal bone 1 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015087	distal carpal bone 2 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015090	distal carpal bone 3 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015093	distal carpal bone 4 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015049	carpus endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015102	distal tarsal bone 1 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015099	distal tarsal endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015105	distal tarsal bone 2 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015099	distal tarsal endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015108	distal tarsal bone 3 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015099	distal tarsal endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015111	distal tarsal bone 4 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015099	distal tarsal endochondral element		
http://purl.obolibrary.org/obo/UBERON_0015114	distal tarsal bone 5 endochondral element	http://purl.obolibrary.org/obo/UBERON_0015099	distal tarsal endochondral element		
http://purl.obolibrary.org/obo/UBERON_0018554	primary lateral incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016476	primary incisor tooth		
http://purl.obolibrary.org/obo/UBERON_0005275	dorsal skin of digit	http://purl.obolibrary.org/obo/UBERON_0015249	digit skin		
http://purl.obolibrary.org/obo/UBERON_0034769	lymphomyeloid tissue	http://purl.obolibrary.org/obo/UBERON_0015757	heterogeneous tissue		
http://purl.obolibrary.org/obo/UBERON_0015850	upper left incisor tusk	http://purl.obolibrary.org/obo/UBERON_0015848	incisor tusk		
http://purl.obolibrary.org/obo/UBERON_0022279	strand of hair on external ear	http://purl.obolibrary.org/obo/UBERON_0016446	hair of head		
http://purl.obolibrary.org/obo/UBERON_0018553	primary central incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016476	primary incisor tooth		
http://purl.obolibrary.org/obo/UBERON_0016480	interlobular stroma of liver	http://purl.obolibrary.org/obo/UBERON_0016478	liver stroma		
http://purl.obolibrary.org/obo/UBERON_0016542	limbic cortex	http://purl.obolibrary.org/obo/UBERON_0016529	cortex of cerebral lobe		
http://purl.obolibrary.org/obo/UBERON_0016551	subdivision of spinal cord ventral column	http://purl.obolibrary.org/obo/UBERON_0016550	spinal cord column		
http://purl.obolibrary.org/obo/UBERON_0016453	lower secondary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0018614	permanent lower tooth		
http://purl.obolibrary.org/obo/UBERON_0017272	lower primary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0018617	primary lower tooth		
http://purl.obolibrary.org/obo/UBERON_0016452	upper secondary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0018613	secondary upper tooth		
http://purl.obolibrary.org/obo/UBERON_0017271	upper primary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0018616	primary upper tooth		
http://purl.obolibrary.org/obo/UBERON_0016454	upper central secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0019253	upper secondary incisor tooth		
http://purl.obolibrary.org/obo/UBERON_0016455	upper lateral secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0019253	upper secondary incisor tooth		
http://purl.obolibrary.org/obo/UBERON_0018667	neck of scapula	http://purl.obolibrary.org/obo/UBERON_0018664	neck of bone element		
http://purl.obolibrary.org/obo/UBERON_0019246	palmar skin crease	http://purl.obolibrary.org/obo/UBERON_3000981	limb external integument structure		
http://purl.obolibrary.org/obo/UBERON_0019247	plantar skin crease	http://purl.obolibrary.org/obo/UBERON_3000981	limb external integument structure		
http://purl.obolibrary.org/obo/UBERON_0019291	white matter of metencephalon	http://purl.obolibrary.org/obo/UBERON_0019258	white matter of hindbrain		
http://purl.obolibrary.org/obo/UBERON_0019269	gray matter of diencephalon	http://purl.obolibrary.org/obo/UBERON_0019264	gray matter of forebrain		
http://purl.obolibrary.org/obo/UBERON_0019293	white matter of pontine tegmentum	http://purl.obolibrary.org/obo/UBERON_0019292	white matter of pons		
http://purl.obolibrary.org/obo/UBERON_0019306	nose epithelium	http://purl.obolibrary.org/obo/UBERON_0019304	sensory organ epithelium		
http://purl.obolibrary.org/obo/UBERON_0022236	peduncle of thalamus	http://purl.obolibrary.org/obo/UBERON_0022235	peduncle of diencephalon		
http://purl.obolibrary.org/obo/UBERON_0034708	cerebellum marginal layer	http://purl.obolibrary.org/obo/UBERON_0034709	hindbrain marginal layer		
http://purl.obolibrary.org/obo/UBERON_0003110	otic region	http://purl.obolibrary.org/obo/UBERON_0034921	multi organ part structure		
http://purl.obolibrary.org/obo/UBERON_0018691	ventral side of post-anal tail	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		
http://purl.obolibrary.org/obo/UBERON_0018692	dorsal side of post-anal tail	http://purl.obolibrary.org/obo/UBERON_0034929	external soft tissue zone		
http://purl.obolibrary.org/obo/UBERON_0019243	skin crease	http://purl.obolibrary.org/obo/UBERON_3000961	external integument structure		
http://purl.obolibrary.org/obo/HP_0004407	Bony paranasal bossing	http://purl.obolibrary.org/obo/HP_0012812	Fullness of paranasal tissue		
http://purl.obolibrary.org/obo/HP_0008729	Absence of labia majora	http://purl.obolibrary.org/obo/HP_0012881	Abnormal labia majora morphology		
http://purl.obolibrary.org/obo/HP_0025029	Abnormal enteric neuron morphology	http://purl.obolibrary.org/obo/HP_0025028	Abnormal enteric nervous system morphology		
http://purl.obolibrary.org/obo/HP_0007459	Generalized anhidrosis	http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology		
http://purl.obolibrary.org/obo/HP_0007550	Hypohidrosis or hyperhidrosis	http://purl.obolibrary.org/obo/HP_0025276	Abnormality of skin adnexa physiology		
http://purl.obolibrary.org/obo/HP_0200085	Limb tremor	http://purl.obolibrary.org/obo/HP_0030188	Tremor by anatomical site		
http://purl.obolibrary.org/obo/HP_0009077	Weakness of long finger extensor muscles	http://purl.obolibrary.org/obo/HP_0030237	Hand muscle weakness		
http://purl.obolibrary.org/obo/HP_0030305	Decreased number of vertebrae	http://purl.obolibrary.org/obo/HP_0030304	Abnormal number of vertebrae		
http://purl.obolibrary.org/obo/HP_0004976	Knee dislocation	http://purl.obolibrary.org/obo/HP_0034670	Abnormal knee physiology		
http://purl.obolibrary.org/obo/HP_0200058	Angiosarcoma	http://purl.obolibrary.org/obo/HP_0030448	Soft tissue sarcoma		
http://purl.obolibrary.org/obo/HP_0030643	Vitelliform-like retinal lesions	http://purl.obolibrary.org/obo/HP_0030506	Yellow/white retinal lesion		
http://purl.obolibrary.org/obo/HP_0009087	Posteriorly placed tongue	http://purl.obolibrary.org/obo/HP_0030809	Abnormal tongue morphology		
http://purl.obolibrary.org/obo/HP_0040173	Abnormality of the tongue muscle	http://purl.obolibrary.org/obo/HP_0040286	Abnormal axial muscle morphology		
http://purl.obolibrary.org/obo/HP_0003984	Posteriorly dislocated ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		
http://purl.obolibrary.org/obo/HP_0003989	Notched ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		
http://purl.obolibrary.org/obo/HP_0003990	Pointed ulna	http://purl.obolibrary.org/obo/HP_0040071	Abnormal morphology of ulna		
http://purl.obolibrary.org/obo/HP_0003957	Cortical thickening of the forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003958	Cross-fusion of the forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003959	Deformed forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003963	Lytic defects of the forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003964	Osteoporotic forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003965	Pseudarthrosis of the forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003966	Sclerotic foci in forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003967	Sclerotic forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003969	Slender forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0003970	Undermodelled forearm bones	http://purl.obolibrary.org/obo/HP_0040072	Abnormal forearm bone morphology		
http://purl.obolibrary.org/obo/HP_0040131	Abnormal motor nerve conduction velocity	http://purl.obolibrary.org/obo/HP_0040129	Abnormal nerve conduction velocity		
http://purl.obolibrary.org/obo/HP_0040132	Abnormal sensory nerve conduction velocity	http://purl.obolibrary.org/obo/HP_0040129	Abnormal nerve conduction velocity		
http://purl.obolibrary.org/obo/HP_0045002	Absent ossification of the trapezium	http://purl.obolibrary.org/obo/HP_0045001	Abnormal ossification of the trapezium		
http://purl.obolibrary.org/obo/NBO_0000121	agonistic behavior	http://purl.obolibrary.org/obo/NBO_0000003	emotional behavior		
http://purl.obolibrary.org/obo/NBO_0000280	attraction-related behavior	http://purl.obolibrary.org/obo/NBO_0000011	social behavior		
http://purl.obolibrary.org/obo/NBO_0000612	communication behavior	http://purl.obolibrary.org/obo/NBO_0000011	social behavior		
http://purl.obolibrary.org/obo/NBO_0000741	aggressive behavior by means	http://purl.obolibrary.org/obo/NBO_0000015	aggressive behavior		
http://purl.obolibrary.org/obo/NBO_0000233	motivation behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		
http://purl.obolibrary.org/obo/NBO_0000003	emotional behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		
http://purl.obolibrary.org/obo/NBO_0000119	impulsive behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		
http://purl.obolibrary.org/obo/NBO_0000607	cognitive behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		
http://purl.obolibrary.org/obo/NBO_0001845	consumption behavior	http://purl.obolibrary.org/obo/NBO_0000313	behavior process		
http://purl.obolibrary.org/obo/NBO_0000609	visual hallucination	http://purl.obolibrary.org/obo/NBO_0000608	hallucination		
http://purl.obolibrary.org/obo/NBO_0000611	olfactory hallucination	http://purl.obolibrary.org/obo/NBO_0000608	hallucination		
http://purl.obolibrary.org/obo/UBERON_0006056	posterior surface of head	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		
http://purl.obolibrary.org/obo/UBERON_0017659	ventral surface of penis	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		
http://purl.obolibrary.org/obo/UBERON_0022288	surface of eyeball	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		
http://purl.obolibrary.org/obo/UBERON_0034928	dorsal surface of penis	http://purl.obolibrary.org/obo/UBERON_0036215	anatomical surface region		
http://purl.obolibrary.org/obo/HP_0005934	Imperfect vocal cord adduction	http://purl.obolibrary.org/obo/HP_0031801	Vocal cord dysfunction		
http://purl.obolibrary.org/obo/HP_5200130	Insistence on sameness	http://purl.obolibrary.org/obo/HP_5200241	Recurrent maladaptive behavior		
http://purl.obolibrary.org/obo/CHEBI_43254	(4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one	http://purl.obolibrary.org/obo/CHEBI_38337	pyrimidone		
http://purl.obolibrary.org/obo/CHEBI_192164	7-Dehydrocholesterol 5,6-oxide	http://purl.obolibrary.org/obo/CHEBI_50401	cholestanoid		
http://purl.obolibrary.org/obo/CHEBI_37253	elemental zinc	http://purl.obolibrary.org/obo/CHEBI_27364	zinc molecular entity		
http://purl.obolibrary.org/obo/CHEBI_47042	hydroxycalciol	http://purl.obolibrary.org/obo/CHEBI_36853	hydroxy seco-steroid		
http://purl.obolibrary.org/obo/CHEBI_47882	cyclic polypyrrole	http://purl.obolibrary.org/obo/CHEBI_38077	polypyrrole		
http://purl.obolibrary.org/obo/CHEBI_35136	iron protein	http://purl.obolibrary.org/obo/CHEBI_35134	metalloprotein		
http://purl.obolibrary.org/obo/CHEBI_35571	mancude organic heterocyclic parent	http://purl.obolibrary.org/obo/CHEBI_35573	organic mancude parent		
http://purl.obolibrary.org/obo/CHEBI_36608	acyclic acid anhydride	http://purl.obolibrary.org/obo/CHEBI_36606	acid anhydride		
http://purl.obolibrary.org/obo/UBERON_0007171	border of scapula	http://purl.obolibrary.org/obo/UBERON_0036304	anatomical border		
http://purl.obolibrary.org/obo/HP_0020341	Unusual periodontitis	http://purl.obolibrary.org/obo/HP_5210280	Unusual oral cavity infection		
http://purl.obolibrary.org/obo/HP_0020326	Increased breast-tissue progesterone receptor expression	http://purl.obolibrary.org/obo/HP_0020323	Abnormal breast-tissue cellular antigen expression		
http://purl.obolibrary.org/obo/UBERON_0036303	vasculature of central nervous system	http://purl.obolibrary.org/obo/UBERON_0036302	vasculature of central nervous system plus retina		
http://purl.obolibrary.org/obo/HP_0008110	Equinovarus deformity	http://purl.obolibrary.org/obo/HP_5210430	Hindfoot deformity		
http://purl.obolibrary.org/obo/HP_0034791	Increased muscle succinate dehydrogenase staining	http://purl.obolibrary.org/obo/HP_0034790	Abnormal muscle succinate dehydrogenase staining		
http://purl.obolibrary.org/obo/HP_0034792	Decreased muscle succinate dehydrogenase staining	http://purl.obolibrary.org/obo/HP_0034790	Abnormal muscle succinate dehydrogenase staining		
http://purl.obolibrary.org/obo/HP_5200132	Atypical sensory examination of objects	http://purl.obolibrary.org/obo/HP_4000079	Sensory seeking		
http://purl.obolibrary.org/obo/HP_5200133	Intense attachment to unusual objects	http://purl.obolibrary.org/obo/HP_5200108	Nonfunctional or atypical use of objects in play		
http://purl.obolibrary.org/obo/HP_0020278	Abnormal lymph-node lymphoctye nuclear morphology	http://purl.obolibrary.org/obo/HP_0020231	Abnormal lymph-node cellular finding		
http://purl.obolibrary.org/obo/HP_0020250	Abnormal lymph node marginal zone morphology	http://purl.obolibrary.org/obo/HP_0020249	Abnormal lymph-node marginal or mantle zone morphology		
http://purl.obolibrary.org/obo/HP_0020251	Abnormal lymph node mantle zone morphology	http://purl.obolibrary.org/obo/HP_0020249	Abnormal lymph-node marginal or mantle zone morphology		
http://purl.obolibrary.org/obo/HP_0020258	Germinal centers with absent marginal zones	http://purl.obolibrary.org/obo/HP_0020250	Abnormal lymph node marginal zone morphology		
http://purl.obolibrary.org/obo/HP_0030880	Raynaud phenomenon	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		
http://purl.obolibrary.org/obo/HP_0030964	Abnormal aortic physiology	http://purl.obolibrary.org/obo/HP_0025323	Abnormal arterial physiology		
http://purl.obolibrary.org/obo/HP_0040184	Oral bleeding	http://purl.obolibrary.org/obo/HP_0031815	Abnormal oral physiology		
http://purl.obolibrary.org/obo/HP_0032531	Elevated CSF gamma-aminobutyric acid concentration	http://purl.obolibrary.org/obo/HP_0500183	Abnormal CSF carboxylic acid concentration		
http://purl.obolibrary.org/obo/HP_0030646	Peripheral	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		
http://purl.obolibrary.org/obo/HP_0030647	Paracentral	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		
http://purl.obolibrary.org/obo/HP_0030648	Midperipheral	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		
http://purl.obolibrary.org/obo/HP_0030649	Pericentral	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		
http://purl.obolibrary.org/obo/HP_0030650	Focal	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		
http://purl.obolibrary.org/obo/HP_0030651	Multifocal	http://purl.obolibrary.org/obo/HP_0012836	Spatial pattern		
http://purl.obolibrary.org/obo/HP_0011472	Abnormal small intestinal villus morphology	http://purl.obolibrary.org/obo/HP_0025129	Abnormal small intestinal mucosa morphology		
http://purl.obolibrary.org/obo/HP_0034787	Accumulation of lipid droplets in small-bowel enterocytes	http://purl.obolibrary.org/obo/HP_0025129	Abnormal small intestinal mucosa morphology		
http://purl.obolibrary.org/obo/HP_0033184	Triggered by infection	http://purl.obolibrary.org/obo/HP_0025204	Triggered by		
http://purl.obolibrary.org/obo/HP_0030078	Lung adenocarcinoma	http://purl.obolibrary.org/obo/HP_0030358	Non-small cell lung carcinoma		
http://purl.obolibrary.org/obo/HP_0030446	Atypical pulmonary carcinoid tumor	http://purl.obolibrary.org/obo/HP_0030445	Pulmonary carcinoid tumor		
http://purl.obolibrary.org/obo/HP_0100289	Abnormality of pattern reversal visual evoked potentials	http://purl.obolibrary.org/obo/HP_0030455	Abnormality of pattern visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030456	Abnormality of pattern onset/offset visual evoked potentials	http://purl.obolibrary.org/obo/HP_0030455	Abnormality of pattern visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030457	Abnormal amplitude of pattern onset/offset visual evoked potentials	http://purl.obolibrary.org/obo/HP_0030456	Abnormality of pattern onset/offset visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030458	Abnormal timing of pattern onset/offset visual evoked potentials	http://purl.obolibrary.org/obo/HP_0030456	Abnormality of pattern onset/offset visual evoked potentials		
http://purl.obolibrary.org/obo/HP_0030485	Abnormal amplitude of pattern electroretinogram	http://purl.obolibrary.org/obo/HP_0030467	Abnormal pattern electroretinogram		
http://purl.obolibrary.org/obo/HP_0030486	Abnormal timing of pattern electroretinogram	http://purl.obolibrary.org/obo/HP_0030467	Abnormal pattern electroretinogram		
http://purl.obolibrary.org/obo/HP_0030487	Abnormal P50/N95 ratio of pattern electroretinogram	http://purl.obolibrary.org/obo/HP_0030467	Abnormal pattern electroretinogram		
http://purl.obolibrary.org/obo/HP_0030488	Abnormal central response of multifocal electroretinogram	http://purl.obolibrary.org/obo/HP_0030468	Abnormal multifocal electroretinogram		
http://purl.obolibrary.org/obo/HP_0030489	Abnormal paracentral response of multifocal electroretinogram	http://purl.obolibrary.org/obo/HP_0030468	Abnormal multifocal electroretinogram		
http://purl.obolibrary.org/obo/HP_0030470	Abnormal dark-adapted bright flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030469	Abnormal dark-adapted electroretinogram		
http://purl.obolibrary.org/obo/HP_0030471	Abnormal dark-adapted dim flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030469	Abnormal dark-adapted electroretinogram		
http://purl.obolibrary.org/obo/HP_0030474	Undetectable dark-adapted electroretinogram	http://purl.obolibrary.org/obo/HP_0030469	Abnormal dark-adapted electroretinogram		
http://purl.obolibrary.org/obo/HP_0030477	Abnormal timing of dark-adapted bright flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030470	Abnormal dark-adapted bright flash electroretinogram		
http://purl.obolibrary.org/obo/HP_0030475	Abnormal timing of dark-adapted dim flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030471	Abnormal dark-adapted dim flash electroretinogram		
http://purl.obolibrary.org/obo/HP_0030476	Abnormal amplitude of dark-adapted dim flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030471	Abnormal dark-adapted dim flash electroretinogram		
http://purl.obolibrary.org/obo/HP_0030481	Abnormal amplitude of light-adapted single flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030472	Abnormal light-adapted single flash electroretinogram		
http://purl.obolibrary.org/obo/HP_0030482	Abnormal timing of light-adapted single flash electroretinogram	http://purl.obolibrary.org/obo/HP_0030472	Abnormal light-adapted single flash electroretinogram		
http://purl.obolibrary.org/obo/HP_0030479	Abnormal amplitude of light-adapted flicker electroretinogram	http://purl.obolibrary.org/obo/HP_0030473	Abnormal light-adapted flicker electroretinogram		
http://purl.obolibrary.org/obo/HP_0030480	Abnormal timing of light-adapted flicker electroretinogram	http://purl.obolibrary.org/obo/HP_0030473	Abnormal light-adapted flicker electroretinogram		
http://purl.obolibrary.org/obo/HP_0030513	Difficulty adjusting from light to dark	http://purl.obolibrary.org/obo/HP_0030512	Difficulty adjusting to changes in luminance		
http://purl.obolibrary.org/obo/HP_0030514	Difficulty adjusting from dark to light	http://purl.obolibrary.org/obo/HP_0030512	Difficulty adjusting to changes in luminance		
http://purl.obolibrary.org/obo/HP_0030518	Congruous homonymous hemianopia	http://purl.obolibrary.org/obo/HP_0030516	Homonymous hemianopia		
http://purl.obolibrary.org/obo/HP_0030519	Congruous heteronymous hemianopia	http://purl.obolibrary.org/obo/HP_0030517	Heteronymous hemianopia		
http://purl.obolibrary.org/obo/HP_0030520	Binasal hemianopia	http://purl.obolibrary.org/obo/HP_0030517	Heteronymous hemianopia		
http://purl.obolibrary.org/obo/HP_0030521	Bitemporal hemianopia	http://purl.obolibrary.org/obo/HP_0030517	Heteronymous hemianopia		
http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test	http://purl.obolibrary.org/obo/HP_0030532	Visual acuity test abnormality		
http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test	http://purl.obolibrary.org/obo/HP_0030532	Visual acuity test abnormality		
http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test	http://purl.obolibrary.org/obo/HP_0030532	Visual acuity test abnormality		
http://purl.obolibrary.org/obo/HP_0030551	Visual acuity light perception with projection	http://purl.obolibrary.org/obo/HP_0030532	Visual acuity test abnormality		
http://purl.obolibrary.org/obo/HP_0030552	Visual acuity light perception without projection	http://purl.obolibrary.org/obo/HP_0030532	Visual acuity test abnormality		
http://purl.obolibrary.org/obo/HP_0030553	Visual acuity no light perception	http://purl.obolibrary.org/obo/HP_0030532	Visual acuity test abnormality		
http://purl.obolibrary.org/obo/HP_0030536	Unaided visual acuity 0.1 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030537	Unaided visual acuity 0.2 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030538	Unaided visual acuity 0.3 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030539	Unaided visual acuity 0.4 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030540	Unaided visual acuity 0.5 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030541	Unaided visual acuity 0.6 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030542	Unaided visual acuity 0.7 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030543	Unaided visual acuity 0.8 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030544	Unaided visual acuity 0.9 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030545	Unaided visual acuity 1.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030546	Unaided visual acuity 1.1 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030547	Unaided visual acuity 1.2 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030548	Unaided visual acuity 1.3 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030549	Unaided visual acuity 2.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030550	Unaided visual acuity 3.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030533	Abnormal unaided visual acuity test		
http://purl.obolibrary.org/obo/HP_0030554	Best corrected visual acuity 0.1 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030555	Best corrected visual acuity 0.2 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030556	Best corrected visual acuity 0.3 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030557	Best corrected visual acuity 0.4 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030558	Best corrected visual acuity 0.5 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030559	Best corrected visual acuity 0.7 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030560	Best corrected visual acuity 0.6 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030561	Best corrected visual acuity 0.8 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030562	Best corrected visual acuity 0.9 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030563	Best corrected visual acuity 1.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030564	Best corrected visual acuity 1.1 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030565	Best corrected visual acuity 1.2 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030566	Best corrected visual acuity 1.3 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030567	Best corrected visual acuity 2.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030568	Best corrected visual acuity 3.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030534	Abnormal best corrected visual acuity test		
http://purl.obolibrary.org/obo/HP_0030569	Pinhole visual acuity 0.1 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030570	Pinhole visual acuity 0.2 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030571	Pinhole visual acuity 0.3 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030572	Pinhole visual acuity 0.4 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030573	Pinhole visual acuity 0.5 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030574	Pinhole visual acuity 0.6 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030575	Pinhole visual acuity 0.7 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030576	Pinhole visual acuity 0.8 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030577	Pinhole visual acuity 0.9 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030578	Pinhole visual acuity 1.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030579	Pinhole visual acuity 1.1 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030580	Pinhole visual acuity 1.2 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030581	Pinhole visual acuity 1.3 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030582	Pinhole visual acuity 2.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030583	Pinhole visual acuity 3.0 LogMAR	http://purl.obolibrary.org/obo/HP_0030535	Abnormal pinhole visual acuity test		
http://purl.obolibrary.org/obo/HP_0030585	Red desaturation	http://purl.obolibrary.org/obo/HP_0030584	Color vision test abnormality		
http://purl.obolibrary.org/obo/HP_0030586	Abnormal Ishihara plate test	http://purl.obolibrary.org/obo/HP_0030584	Color vision test abnormality		
http://purl.obolibrary.org/obo/HP_0030587	Abnormal Hardy-Rand-Rittler plate test	http://purl.obolibrary.org/obo/HP_0030584	Color vision test abnormality		
http://purl.obolibrary.org/obo/HP_0030589	Abnormal confrontational visual field test	http://purl.obolibrary.org/obo/HP_0030588	Abnormal visual field test		
http://purl.obolibrary.org/obo/HP_0030590	Abnormal Amsler grid test	http://purl.obolibrary.org/obo/HP_0030588	Abnormal visual field test		
http://purl.obolibrary.org/obo/HP_0030591	Abnormal kinetic perimetry test	http://purl.obolibrary.org/obo/HP_0030588	Abnormal visual field test		
http://purl.obolibrary.org/obo/HP_0030592	Abnormal static perimetry test	http://purl.obolibrary.org/obo/HP_0030588	Abnormal visual field test		
http://purl.obolibrary.org/obo/HP_0030593	Abnormal manual kinetic perimetry test	http://purl.obolibrary.org/obo/HP_0030591	Abnormal kinetic perimetry test		
http://purl.obolibrary.org/obo/HP_0030594	Abnormal automated kinetic perimetry test	http://purl.obolibrary.org/obo/HP_0030591	Abnormal kinetic perimetry test		
http://purl.obolibrary.org/obo/HP_0030595	Abnormal static automated perimetry test	http://purl.obolibrary.org/obo/HP_0030592	Abnormal static perimetry test		
http://purl.obolibrary.org/obo/HP_0030596	Abnormal Humphrey SITA 30-2 perimetry test	http://purl.obolibrary.org/obo/HP_0030595	Abnormal static automated perimetry test		
http://purl.obolibrary.org/obo/HP_0030597	Abnormal Humphrey SITA 24-2 perimetry test	http://purl.obolibrary.org/obo/HP_0030595	Abnormal static automated perimetry test		
http://purl.obolibrary.org/obo/HP_0030598	Abnormal Humphrey SITA 10-2 perimetry test	http://purl.obolibrary.org/obo/HP_0030595	Abnormal static automated perimetry test		
http://purl.obolibrary.org/obo/HP_0030605	Abnormal indocyanine green angiography	http://purl.obolibrary.org/obo/HP_0030601	Abnormal posterior segment imaging		
http://purl.obolibrary.org/obo/HP_0030629	Perifoveal ring of hyperautofluorescence	http://purl.obolibrary.org/obo/HP_0030602	Abnormal fundus autofluorescence imaging		
http://purl.obolibrary.org/obo/HP_0030630	Irregular central macular autofluorescence	http://purl.obolibrary.org/obo/HP_0030602	Abnormal fundus autofluorescence imaging		
http://purl.obolibrary.org/obo/HP_0030611	Retinal pigment epithelial loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030603	Abnormal optical coherence tomography		
http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT	http://purl.obolibrary.org/obo/HP_0030603	Abnormal optical coherence tomography		
http://purl.obolibrary.org/obo/HP_0030607	Reduced OCT-measured macular thickness	http://purl.obolibrary.org/obo/HP_0030606	Abnormal OCT-measured macular thickness		
http://purl.obolibrary.org/obo/HP_0030608	Increased OCT-measured macular thickness	http://purl.obolibrary.org/obo/HP_0030606	Abnormal OCT-measured macular thickness		
http://purl.obolibrary.org/obo/HP_0030606	Abnormal OCT-measured macular thickness	http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030610	Photoreceptor outer segment loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT	http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030620	Inner retinal layer loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030625	Hyporeflective spaces on macular OCT	http://purl.obolibrary.org/obo/HP_0030612	Abnormal retinal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030614	Foveal photoreceptor layer loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030615	Foveal photoreceptor outer segment loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030616	Foveal retinal pigment epithelial loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030617	Abnormal OCT-measured foveal thickness	http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030621	Foveal inner retinal layer loss on macular OCT	http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030622	Abnormal foveal pit on macular OCT	http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030627	Foveal hyporeflective spaces on macular OCT	http://purl.obolibrary.org/obo/HP_0030613	Abnormal foveal morphology on macular OCT		
http://purl.obolibrary.org/obo/HP_0030618	Increased OCT-measured foveal thickness	http://purl.obolibrary.org/obo/HP_0030617	Abnormal OCT-measured foveal thickness		
http://purl.obolibrary.org/obo/HP_0030619	Reduced OCT-measured foveal thickness	http://purl.obolibrary.org/obo/HP_0030617	Abnormal OCT-measured foveal thickness		
http://purl.obolibrary.org/obo/HP_0030623	Intraretinal hyporeflective spaces on macular OCT	http://purl.obolibrary.org/obo/HP_0030625	Hyporeflective spaces on macular OCT		
http://purl.obolibrary.org/obo/HP_0030624	Subretinal hyporeflective spaces on macular OCT	http://purl.obolibrary.org/obo/HP_0030625	Hyporeflective spaces on macular OCT		
http://purl.obolibrary.org/obo/HP_0030626	Foveal intraretinal hyporeflective spaces on macular OCT	http://purl.obolibrary.org/obo/HP_0030627	Foveal hyporeflective spaces on macular OCT		
http://purl.obolibrary.org/obo/HP_0030628	Foveal subretinal hyporeflective spaces on macular OCT	http://purl.obolibrary.org/obo/HP_0030627	Foveal hyporeflective spaces on macular OCT		
http://purl.obolibrary.org/obo/HP_0030633	Perifoveal ring of hyperautofluorescence surrounded by normal autofluorescence	http://purl.obolibrary.org/obo/HP_0030629	Perifoveal ring of hyperautofluorescence		
http://purl.obolibrary.org/obo/HP_0030634	Perifoveal ring of hyperautofluorescence surrounded by abnormal autofluorescence	http://purl.obolibrary.org/obo/HP_0030629	Perifoveal ring of hyperautofluorescence		
http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score	http://purl.obolibrary.org/obo/HP_0030917	Low APGAR score		
http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score	http://purl.obolibrary.org/obo/HP_0030917	Low APGAR score		
http://purl.obolibrary.org/obo/HP_0030927	1-minute APGAR score of 0	http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030928	1-minute APGAR score of 1	http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030929	1-minute APGAR score of 2	http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030930	1-minute APGAR score of 3	http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030931	1-minute APGAR score of 4	http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030932	1-minute APGAR score of 5	http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030933	1-minute APGAR score of 6	http://purl.obolibrary.org/obo/HP_0030918	Low 1-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030920	5-minute APGAR score of 0	http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030921	5-minute APGAR score of 1	http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030922	5-minute APGAR score of 2	http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030923	5-minute APGAR score of 3	http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030924	5-minute APGAR score of 4	http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030925	5-minute APGAR score of 5	http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0030926	5-minute APGAR score of 6	http://purl.obolibrary.org/obo/HP_0030919	Low 5-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0040046	Abnormal left hemidiaphragm morphology	http://purl.obolibrary.org/obo/HP_0040045	Abnormal hemidiaphragm morphology		
http://purl.obolibrary.org/obo/HP_0040047	Abnormal right hemidiaphragm morphology	http://purl.obolibrary.org/obo/HP_0040045	Abnormal hemidiaphragm morphology		
http://purl.obolibrary.org/obo/HP_0040116	Aplasia of the Eustachian tube	http://purl.obolibrary.org/obo/HP_0040115	Abnormal Eustachian tube morphology		
http://purl.obolibrary.org/obo/HP_0040117	Atresia of the Eustachian tube	http://purl.obolibrary.org/obo/HP_0040115	Abnormal Eustachian tube morphology		
http://purl.obolibrary.org/obo/HP_0040118	Stenosis of the Eustachian tube	http://purl.obolibrary.org/obo/HP_0040115	Abnormal Eustachian tube morphology		
http://purl.obolibrary.org/obo/HP_0040269	Blocked Eustachian tube	http://purl.obolibrary.org/obo/HP_0040115	Abnormal Eustachian tube morphology		
http://purl.obolibrary.org/obo/HP_0040114	Absence of the reflex of the tensor tympani muscle	http://purl.obolibrary.org/obo/HP_0040120	Abnormality of the reflex of the tensor tympani muscle		
http://purl.obolibrary.org/obo/HP_0040123	Impairment of the reflex of the tensor tympani muscle	http://purl.obolibrary.org/obo/HP_0040120	Abnormality of the reflex of the tensor tympani muscle		
http://purl.obolibrary.org/obo/HP_0040128	Abnormal sweat electrolytes	http://purl.obolibrary.org/obo/HP_0040127	Abnormal sweat homeostasis		
http://purl.obolibrary.org/obo/HP_0040147	L-2-hydroxyglutaric acidemia	http://purl.obolibrary.org/obo/HP_0040145	Dicarboxylic acidemia		
http://purl.obolibrary.org/obo/HP_0040146	D-2-hydroxyglutaric acidemia	http://purl.obolibrary.org/obo/HP_0040145	Dicarboxylic acidemia		
http://purl.obolibrary.org/obo/HP_0040174	Abnormality of extrinsic muscle of tongue	http://purl.obolibrary.org/obo/HP_0040173	Abnormality of the tongue muscle		
http://purl.obolibrary.org/obo/HP_0040177	Abnormal level of platelet-activating factor	http://purl.obolibrary.org/obo/HP_0040176	Abnormal circulating phospholipid concentration		
http://purl.obolibrary.org/obo/HP_0040178	Increased level of platelet-activating factor	http://purl.obolibrary.org/obo/HP_0040177	Abnormal level of platelet-activating factor		
http://purl.obolibrary.org/obo/HP_0040179	Decreased level of platelet-activating factor	http://purl.obolibrary.org/obo/HP_0040177	Abnormal level of platelet-activating factor		
http://purl.obolibrary.org/obo/HP_0040190	White scaling skin	http://purl.obolibrary.org/obo/HP_0040189	Scaling skin		
http://purl.obolibrary.org/obo/HP_0040254	Decreased size of the clitoris	http://purl.obolibrary.org/obo/HP_0040252	Abnormal size of the clitoris		
http://purl.obolibrary.org/obo/HP_0040266	Proximal upper limb muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0040265	Upper limb muscle hypertrophy		
http://purl.obolibrary.org/obo/HP_0040267	Distal upper limb muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0040265	Upper limb muscle hypertrophy		
http://purl.obolibrary.org/obo/HP_0045054	Brachial plexus neuropathy	http://purl.obolibrary.org/obo/HP_0045052	Abnormality of the brachial nerve plexus		
http://purl.obolibrary.org/obo/HP_0200158	Agenesis of permanent mandibular lateral incisor	http://purl.obolibrary.org/obo/HP_0200154	Agenesis of mandibular lateral incisor		
http://purl.obolibrary.org/obo/HP_0200159	Agenesis of primary mandibular lateral incisor	http://purl.obolibrary.org/obo/HP_0200154	Agenesis of mandibular lateral incisor		
http://purl.obolibrary.org/obo/MPATH_346	autoimmune mediated disease	http://purl.obolibrary.org/obo/MPATH_194	immune mediated disease		
http://purl.obolibrary.org/obo/MPATH_675	psoriasiform dermatitis	http://purl.obolibrary.org/obo/MPATH_196	dermatitis		
http://purl.obolibrary.org/obo/NBO_0000444	eye movement	http://purl.obolibrary.org/obo/NBO_0000001	body part movement		
http://purl.obolibrary.org/obo/NBO_0000388	involuntary movement behavior	http://purl.obolibrary.org/obo/NBO_0000001	body part movement		
http://purl.obolibrary.org/obo/NBO_0000015	aggressive behavior	http://purl.obolibrary.org/obo/NBO_0000003	emotional behavior		
http://purl.obolibrary.org/obo/NBO_0000129	agitation behavior	http://purl.obolibrary.org/obo/NBO_0000003	emotional behavior		
http://purl.obolibrary.org/obo/NBO_0000617	laughing behavior	http://purl.obolibrary.org/obo/NBO_0000003	emotional behavior		
http://purl.obolibrary.org/obo/NBO_0000620	frustration behavior	http://purl.obolibrary.org/obo/NBO_0000003	emotional behavior		
http://purl.obolibrary.org/obo/NBO_0000018	fear/anxiety related behavior	http://purl.obolibrary.org/obo/NBO_0000469	stress related behavior		
http://purl.obolibrary.org/obo/NBO_0000747	jaw movement	http://purl.obolibrary.org/obo/NBO_0000007	mouth movement		
http://purl.obolibrary.org/obo/NBO_0000092	anxiety-related behavior	http://purl.obolibrary.org/obo/NBO_0000018	fear/anxiety related behavior		
http://purl.obolibrary.org/obo/NBO_0000054	suckling behavior	http://purl.obolibrary.org/obo/NBO_0000079	feeding behavior		
http://purl.obolibrary.org/obo/NBO_0000130	liquid consumption	http://purl.obolibrary.org/obo/NBO_0000079	feeding behavior		
http://purl.obolibrary.org/obo/NBO_0000134	food consumption	http://purl.obolibrary.org/obo/NBO_0000079	feeding behavior		
http://purl.obolibrary.org/obo/NBO_0000128	irritability behavior	http://purl.obolibrary.org/obo/NBO_0000121	agonistic behavior		
http://purl.obolibrary.org/obo/NBO_0000455	attention behavior	http://purl.obolibrary.org/obo/NBO_0000308	sensation behavior		
http://purl.obolibrary.org/obo/NBO_0000608	hallucination	http://purl.obolibrary.org/obo/NBO_0000308	sensation behavior		
http://purl.obolibrary.org/obo/NBO_0000751	perception behavior by means	http://purl.obolibrary.org/obo/NBO_0000308	sensation behavior		
http://purl.obolibrary.org/obo/NBO_0000355	posture	http://purl.obolibrary.org/obo/NBO_0000317	vestibular behavior		
http://purl.obolibrary.org/obo/NBO_0000317	vestibular behavior	http://purl.obolibrary.org/obo/NBO_0000327	somatic sensation related behavior		
http://purl.obolibrary.org/obo/NBO_0000347	gross motor coordination	http://purl.obolibrary.org/obo/NBO_0000339	motor coordination		
http://purl.obolibrary.org/obo/NBO_0000357	limb posture	http://purl.obolibrary.org/obo/NBO_0000355	posture		
http://purl.obolibrary.org/obo/NBO_0000356	body posture	http://purl.obolibrary.org/obo/NBO_0000355	posture		
http://purl.obolibrary.org/obo/NBO_0000389	reflexive behavior	http://purl.obolibrary.org/obo/NBO_0000388	involuntary movement behavior		
http://purl.obolibrary.org/obo/NBO_0000411	cranial nerve related reflex	http://purl.obolibrary.org/obo/NBO_0000389	reflexive behavior		
http://purl.obolibrary.org/obo/NBO_0000308	sensation behavior	http://purl.obolibrary.org/obo/NBO_0000607	cognitive behavior		
http://purl.obolibrary.org/obo/NBO_0000327	somatic sensation related behavior	http://purl.obolibrary.org/obo/NBO_0000751	perception behavior by means		
http://purl.obolibrary.org/obo/NBO_0002169	regulation of consumption behavior	http://purl.obolibrary.org/obo/NBO_0001786	regulation of behavior		
http://purl.obolibrary.org/obo/NBO_0002436	regulation of feeding behavior	http://purl.obolibrary.org/obo/NBO_0002169	regulation of consumption behavior		
http://purl.obolibrary.org/obo/NBO_0000063	regulation of eating behavior	http://purl.obolibrary.org/obo/NBO_0002436	regulation of feeding behavior		
http://purl.obolibrary.org/obo/NBO_0000064	regulation of drinking behavior	http://purl.obolibrary.org/obo/NBO_0002436	regulation of feeding behavior		
http://purl.obolibrary.org/obo/UBERON_0037447	wall of male urethra	http://purl.obolibrary.org/obo/UBERON_0036521	wall of urethra		
http://purl.obolibrary.org/obo/UBERON_0037455	wall of female urethra	http://purl.obolibrary.org/obo/UBERON_0036521	wall of urethra		
http://purl.obolibrary.org/obo/UBERON_0036654	wall of lateral ventricle	http://purl.obolibrary.org/obo/UBERON_0036661	wall of ventricular system of brain		
http://purl.obolibrary.org/obo/UBERON_0036655	wall of cerebral aqueduct	http://purl.obolibrary.org/obo/UBERON_0036661	wall of ventricular system of brain		
http://purl.obolibrary.org/obo/UBERON_0036656	wall of third ventricle	http://purl.obolibrary.org/obo/UBERON_0036661	wall of ventricular system of brain		
http://purl.obolibrary.org/obo/UBERON_0036657	wall of fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0036661	wall of ventricular system of brain		
http://purl.obolibrary.org/obo/HP_0033133	Renal cortical hypoechogeneity	http://purl.obolibrary.org/obo/HP_0033130	Abnormal renal echogenicity		
http://purl.obolibrary.org/obo/HP_0007549	Desquamation of skin soon after birth	http://purl.obolibrary.org/obo/HP_0025723	Abnormal fetal skin morphology		
http://purl.obolibrary.org/obo/HP_0100718	Uterine rupture	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		
http://purl.obolibrary.org/obo/HP_0100878	Enlarged uterus	http://purl.obolibrary.org/obo/HP_0031105	Abnormal uterus morphology		
http://purl.obolibrary.org/obo/UBERON_0016910	frenulum of lip	http://purl.obolibrary.org/obo/UBERON_0036294	mucosa of lip		
http://purl.obolibrary.org/obo/HP_0006549	Unilateral primary pulmonary dysgenesis	http://purl.obolibrary.org/obo/HP_4000059	Abnormal lung development		
http://purl.obolibrary.org/obo/HP_5200100	Facial expressions not directed to others	http://purl.obolibrary.org/obo/HP_4000087	Abnormal communicative facial expressions		
http://purl.obolibrary.org/obo/HP_5200101	Limited Repertoire of gestures	http://purl.obolibrary.org/obo/HP_4000090	Abnormal gesture use		
http://purl.obolibrary.org/obo/UBERON_0001560	neck of organ	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		
http://purl.obolibrary.org/obo/UBERON_0005913	zone of bone organ	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		
http://purl.obolibrary.org/obo/UBERON_0011140	superficial part of masseter muscle	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		
http://purl.obolibrary.org/obo/UBERON_0011313	posterior subdivision of masseter	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		
http://purl.obolibrary.org/obo/UBERON_0011314	anterior subdivision of masseter	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		
http://purl.obolibrary.org/obo/UBERON_0035606	cartilage of external acoustic meatus	http://purl.obolibrary.org/obo/UBERON_0034944	zone of organ		
http://purl.obolibrary.org/obo/HP_0032776	Focal aware autonomic seizure with lacrimation	http://purl.obolibrary.org/obo/HP_0032771	Focal autonomic seizure with lacrimation		
http://purl.obolibrary.org/obo/HP_0032812	Neonatal electro-clinical non-motor seizure	http://purl.obolibrary.org/obo/HP_0032809	Neonatal electro-clinical seizure		
http://purl.obolibrary.org/obo/HP_0004571	Widening of cervical spinal canal	http://purl.obolibrary.org/obo/HP_0046508	Abnormal cervical spine morphology		
http://purl.obolibrary.org/obo/HP_0005502	Increased red cell osmotic fragility	http://purl.obolibrary.org/obo/HP_0020054	Abnormal erythrocyte physiology		
http://purl.obolibrary.org/obo/HP_0005546	Increased red cell osmotic resistance	http://purl.obolibrary.org/obo/HP_0020054	Abnormal erythrocyte physiology		
http://purl.obolibrary.org/obo/HP_0007449	Confetti-like hypopigmented macules	http://purl.obolibrary.org/obo/HP_0020073	Hypopigmented macule		
http://purl.obolibrary.org/obo/HP_0008167	Very long chain fatty acid accumulation	http://purl.obolibrary.org/obo/HP_0032243	Abnormal tissue metabolite concentration		
http://purl.obolibrary.org/obo/HP_0034406	Elevated CSF angiotensin-converting enzyme concentration	http://purl.obolibrary.org/obo/HP_0025456	Abnormal CSF protein concentration		
http://purl.obolibrary.org/obo/HP_0410211	Abnormal blood gas level in cord blood	http://purl.obolibrary.org/obo/HP_0410210	Abnormal cord blood measurement		
http://purl.obolibrary.org/obo/HP_0500239	Increased CSF albumin concentration	http://purl.obolibrary.org/obo/HP_0500238	Abnormal CSF albumin concentration		
http://purl.obolibrary.org/obo/HP_0033468	10-minute APGAR score of 0	http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0033469	10-minute APGAR score of 1	http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0033470	10-minute APGAR score of 2	http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0033471	10-minute APGAR score of 3	http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0033472	10-minute APGAR score of 4	http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0033473	10-minute APGAR score of 5	http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score		
http://purl.obolibrary.org/obo/HP_0033474	10-minute APGAR score of 6	http://purl.obolibrary.org/obo/HP_0033467	Low 10-minute APGAR score		
http://purl.obolibrary.org/obo/UBERON_0005423	developing anatomical structure	http://purl.obolibrary.org/obo/UBERON_0000001	gross anatomical part		
http://purl.obolibrary.org/obo/HP_0033067	Cystine crystalluria	http://purl.obolibrary.org/obo/HP_0020074	Crystalluria		
http://purl.obolibrary.org/obo/HP_0004920	Phenylpyruvic acidemia	http://purl.obolibrary.org/obo/HP_0032368	Acidemia		
http://purl.obolibrary.org/obo/HP_0034575	Reduced epidermal collagen IV protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		
http://purl.obolibrary.org/obo/HP_0034577	Reduced epidermal collagen VII protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		
http://purl.obolibrary.org/obo/HP_0034578	Reduced epidermal collagen XVII protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		
http://purl.obolibrary.org/obo/HP_0034579	Reduced epidermal integrin alpha6beta4 protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		
http://purl.obolibrary.org/obo/HP_0034580	Reduced epidermal plectin protein expression	http://purl.obolibrary.org/obo/HP_0034573	Abnormal epidermal protein expression		
http://purl.obolibrary.org/obo/HP_0040134	Abnormal hepatic iron concentration	http://purl.obolibrary.org/obo/HP_0034644	Abnormal liver metabolite concentration		
http://purl.obolibrary.org/obo/HP_0045061	Decreased carnitine level in liver	http://purl.obolibrary.org/obo/HP_0034644	Abnormal liver metabolite concentration		
http://purl.obolibrary.org/obo/HP_0006466	Ankle flexion contracture	http://purl.obolibrary.org/obo/HP_0034677	Ankle contracture		
http://purl.obolibrary.org/obo/HP_0034678	Forefoot pronation contracture	http://purl.obolibrary.org/obo/HP_0034677	Ankle contracture		
http://purl.obolibrary.org/obo/HP_0034679	Forefoot supination contracture	http://purl.obolibrary.org/obo/HP_0034677	Ankle contracture		
http://purl.obolibrary.org/obo/HP_0034680	Forefoot adduction contracture	http://purl.obolibrary.org/obo/HP_0034677	Ankle contracture		
http://purl.obolibrary.org/obo/HP_5200116	Difficulty understanding nonliteral meaning of conversation	http://purl.obolibrary.org/obo/HP_5200021	Reduced social insight		
http://purl.obolibrary.org/obo/HP_5200117	Poor recognition of injustice	http://purl.obolibrary.org/obo/HP_5200021	Reduced social insight		
http://purl.obolibrary.org/obo/HP_5200119	Difficulty understanding humor	http://purl.obolibrary.org/obo/HP_5200021	Reduced social insight		
http://purl.obolibrary.org/obo/CHEBI_36342	subatomic particle				A particle smaller than an atom.
http://purl.obolibrary.org/obo/GO_0005575	cellular_component				A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
http://purl.obolibrary.org/obo/GO_0005623	obsolete cell				OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
http://purl.obolibrary.org/obo/GO_0006486	obsolete protein glycosylation				OBSOLETE. A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
http://purl.obolibrary.org/obo/UBERON_0000104	life cycle				An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism.
http://purl.obolibrary.org/obo/UBERON_0000105	life cycle stage				A spatiotemporal region encompassing some part of the life cycle of an organism.
http://purl.obolibrary.org/obo/UBERON_0001062	anatomical entity				Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
http://purl.obolibrary.org/obo/HsapDv_0000000	life cycle stage				A spatiotemporal region encompassing some part of the life cycle of an organism.
http://purl.obolibrary.org/obo/GO_0003674	molecular_function				A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
http://purl.obolibrary.org/obo/GO_0008150	biological_process				A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
http://purl.obolibrary.org/obo/GO_0070085	obsolete glycosylation				OBSOLETE. The covalent attachment and further modification of carbohydrate residues to a substrate molecule.
http://purl.obolibrary.org/obo/GO_0046323	obsolete D-glucose import				OBSOLETE. The directed movement of the hexose monosaccharide D-glucose into a cell or organelle.
http://purl.obolibrary.org/obo/PR_000018263	amino acid chain				A molecule that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.
http://purl.obolibrary.org/obo/RO_0002577	system				A material entity consisting of multiple components that are causally integrated.
http://purl.obolibrary.org/obo/HP_0040083	obsolete Toe walking				Toe walking is a pattern of walking in which a person walks on balls of his or her feet, with no contact between the heels and ground. Toe-walking is common in children who are learning to walk, but most children outgrow it around the age of two years. This term refers to the persistence of toe-walking beyond the usual age.
http://purl.obolibrary.org/obo/HP_0034379	obsolete Vascular granular osmiophilic material deposition				Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide.
http://purl.obolibrary.org/obo/HP_0032697	obsolete Focal cognitive seizure with deja vu/jamais vu				A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation.
http://purl.obolibrary.org/obo/HP_0500267	obsolete Abnormal proportion of CD4-positive helper T cells				An abnormal proportion of circulating CD4-positive helper T cells relative to total T cell count.
http://purl.obolibrary.org/obo/HP_0034113	obsolete Anti-type I liver-kidney microsomal antibody positivity				The presence of type I liver-kidney microsomal autoantibodies (immunoglobulins) in the blood circulation.
http://purl.obolibrary.org/obo/HP_0000489	obsolete Abnormality of globe location or size				
http://purl.obolibrary.org/obo/HP_0001113	obsolete Early cataracts				
http://purl.obolibrary.org/obo/HP_0003114	obsolete Abnormal cardiological findings				
http://purl.obolibrary.org/obo/HP_0003340	obsolete Abnormal dermatological laboratory findings				
http://purl.obolibrary.org/obo/HP_0003494	obsolete Loss of heterozygosity, multiple chromosomes				
http://purl.obolibrary.org/obo/HP_0003975	obsolete Chevron-shaped/cone-shaped radius				
http://purl.obolibrary.org/obo/HP_0004038	obsolete Bony spicule of ulnar epiphyseal plate				
http://purl.obolibrary.org/obo/HP_0004059	obsolete radial ray deficiency				
http://purl.obolibrary.org/obo/HP_0004066	obsolete Laterally deviated thumb phalanges				
http://purl.obolibrary.org/obo/HP_0004083	obsolete Laterally deviated terminal thumb phalanx				
http://purl.obolibrary.org/obo/HP_0004090	obsolete Advanced maturation/advanced ossification of terminal thumb phalanx epiphysis				
http://purl.obolibrary.org/obo/HP_0004110	obsolete Radially deviated index finger phalanges				
http://purl.obolibrary.org/obo/HP_0004121	obsolete Radially displaced proximal index finger phalanx				
http://purl.obolibrary.org/obo/HP_0004138	obsolete Metaphyseal abnormality of middle phalanx of the 2nd finger				
http://purl.obolibrary.org/obo/HP_0004139	obsolete Flared metaphysis of middle phalanx of index finger				
http://purl.obolibrary.org/obo/HP_0004143	obsolete Radially deviated terminal index finger phalanx				
http://purl.obolibrary.org/obo/HP_0004144	obsolete Duplication of terminal index finger phalanx				
http://purl.obolibrary.org/obo/HP_0004153	obsolete Overgrowth of middle finger				
http://purl.obolibrary.org/obo/HP_0004157	obsolete Accessory middle-finger phalanges				
http://purl.obolibrary.org/obo/HP_0004161	obsolete Periosteal new bone of middle finger phalanges				
http://purl.obolibrary.org/obo/HP_0004162	obsolete Radially pointed middle finger phalanges				
http://purl.obolibrary.org/obo/HP_0004168	obsolete Radially pointed proximal middle-finger phalanx				
http://purl.obolibrary.org/obo/HP_0004174	obsolete Accessory middle phalanx of middle finger				
http://purl.obolibrary.org/obo/HP_0004175	obsolete Periosteal new bone of middle phalanx of middle-finger				
http://purl.obolibrary.org/obo/HP_0004183	obsolete Abnormality of the epiphyses of the terminal phalanx of the middle finger				
http://purl.obolibrary.org/obo/HP_0004184	obsolete Cone-shaped epiphysis of terminal phalanx of the middle finger				
http://purl.obolibrary.org/obo/HP_0004185	obsolete Fused epiphysis of terminal phalanx of the middle finger				
http://purl.obolibrary.org/obo/HP_0004186	obsolete Large epiphysis of terminal phalanx of the middle finger				
http://purl.obolibrary.org/obo/HP_0004187	obsolete Prematurely fused epiphysis of terminal phalanx of the middle finger				
http://purl.obolibrary.org/obo/HP_0004192	obsolete Bracket epiphyses of the 4th finger				
http://purl.obolibrary.org/obo/HP_0004193	obsolete Expanded phalanges of the ring finger				
http://purl.obolibrary.org/obo/HP_0004194	obsolete Hypoplastic phalanges of the ring finger				
http://purl.obolibrary.org/obo/HP_0004196	obsolete Short phalanges of the ring finger				
http://purl.obolibrary.org/obo/HP_0004198	obsolete Wide/broad phalanges of the ring finger				
http://purl.obolibrary.org/obo/HP_0004201	obsolete Expanded proximal phalanx of the ring finger				
http://purl.obolibrary.org/obo/HP_0004202	obsolete Lytic defects of the proximal phalanx of the ring finger				
http://purl.obolibrary.org/obo/HP_0004203	obsolete Short proximal phalanx of the ring finger				
http://purl.obolibrary.org/obo/HP_0004478	obsolete Ethmoidal encephalocele				
http://purl.obolibrary.org/obo/HP_0004495	obsolete Thin anteverted nares				
http://purl.obolibrary.org/obo/HP_0004496	obsolete Posterior choanal atresia				
http://purl.obolibrary.org/obo/HP_0004544	obsolete Pointed frontal hairline				
http://purl.obolibrary.org/obo/HP_0004759	obsolete Nodular calcific aortic valve disease				
http://purl.obolibrary.org/obo/HP_0004760	obsolete Congenital septal defect				
http://purl.obolibrary.org/obo/HP_0004782	obsolete Hypotrichosis of the scalp				
http://purl.obolibrary.org/obo/HP_0004928	obsolete Peripheral arterial stenosis				
http://purl.obolibrary.org/obo/HP_0004929	obsolete Coronary atherosclerosis				
http://purl.obolibrary.org/obo/HP_0004953	obsolete Dilatation of abdominal aorta				
http://purl.obolibrary.org/obo/HP_0004954	obsolete Dilatation of the descending aorta				
http://purl.obolibrary.org/obo/HP_0004986	obsolete Rudimentary to absent fibulae				
http://purl.obolibrary.org/obo/HP_0005099	obsolete Severe hydrops fetalis				
http://purl.obolibrary.org/obo/HP_0005114	obsolete Abnormalities of the peripheral arteries				
http://purl.obolibrary.org/obo/HP_0005130	obsolete Restrictive heart failure				
http://purl.obolibrary.org/obo/HP_0005141	obsolete Episodes of ventricular tachycardia				
http://purl.obolibrary.org/obo/HP_0005173	obsolete Calcific aortic valve stenosis				
http://purl.obolibrary.org/obo/HP_0005296	obsolete Occlusive vascular disease				
http://purl.obolibrary.org/obo/HP_0005298	obsolete Atrioventricular canal defect with right ventricle aorta and pulmonary atresia				
http://purl.obolibrary.org/obo/HP_0005299	obsolete Premature peripheral vascular disease				
http://purl.obolibrary.org/obo/HP_0005309	obsolete Peripheral vascular insufficiency				
http://purl.obolibrary.org/obo/HP_0005315	obsolete Peripheral artery occlusive disease				
http://purl.obolibrary.org/obo/HP_0005354	obsolete Absent cellular immunity				
http://purl.obolibrary.org/obo/HP_0005364	obsolete Severe viral infections				
http://purl.obolibrary.org/obo/HP_0005365	obsolete Severe B lymphocytopenia				
http://purl.obolibrary.org/obo/HP_0005375	obsolete Partial cellular immunodeficiency				
http://purl.obolibrary.org/obo/HP_0005379	obsolete Severe T lymphocytopenia				
http://purl.obolibrary.org/obo/HP_0005397	obsolete Exaggerated cellular immune processes				
http://purl.obolibrary.org/obo/HP_0005402	obsolete Primary T-lymphocyte immune abnormalities				
http://purl.obolibrary.org/obo/HP_0005407	obsolete Decreased proportion of CD4-positive helper T cells				
http://purl.obolibrary.org/obo/HP_0005409	obsolete Markedly reduced T cell function				
http://purl.obolibrary.org/obo/HP_0005435	obsolete Impaired T cell function				
http://purl.obolibrary.org/obo/HP_0005512	obsolete Impaired neutrophil killing of staphylococci				
http://purl.obolibrary.org/obo/HP_0005540	obsolete Red blood cell keratocytosis				
http://purl.obolibrary.org/obo/HP_0005549	obsolete Congenital neutropenia				
http://purl.obolibrary.org/obo/HP_0005587	obsolete Profuse pigmented skin lesions				
http://purl.obolibrary.org/obo/HP_0005692	obsolete Joint hyperflexibility				
http://purl.obolibrary.org/obo/HP_0005744	obsolete Generalized osteoporosis with pathologic fractures				
http://purl.obolibrary.org/obo/HP_0005788	obsolete Abnormal cervical myelogram				
http://purl.obolibrary.org/obo/HP_0005794	obsolete Arterial disease of legs				
http://purl.obolibrary.org/obo/HP_0005807	obsolete Absent distal finger phalanx				
http://purl.obolibrary.org/obo/HP_0005833	obsolete Joint swelling onset late infancy				
http://purl.obolibrary.org/obo/HP_0005834	obsolete Thumbs hypo/aplastic				
http://purl.obolibrary.org/obo/HP_0005837	obsolete Joint dislocations in young adult				
http://purl.obolibrary.org/obo/HP_0005848	obsolete Bifid thumb distal phalanx				
http://purl.obolibrary.org/obo/HP_0005899	obsolete Metaphyseal dysostosis				
http://purl.obolibrary.org/obo/HP_0005901	obsolete Chronic recurrent multifocal osteomyelitis				
http://purl.obolibrary.org/obo/HP_0005921	obsolete Abnormal ossification of hand bones				
http://purl.obolibrary.org/obo/HP_0005952	obsolete Decreased pulmonary function				
http://purl.obolibrary.org/obo/HP_0005984	obsolete Elevated maternal serum alpha-fetoprotein				
http://purl.obolibrary.org/obo/HP_0006069	obsolete Severe carpal ossification delay				
http://purl.obolibrary.org/obo/HP_0006153	obsolete Disharmonious carpal bone				
http://purl.obolibrary.org/obo/HP_0006158	obsolete Finger joint hyperextensibility				
http://purl.obolibrary.org/obo/HP_0006187	obsolete Fusion of midphalangeal joints				
http://purl.obolibrary.org/obo/HP_0006334	obsolete Hypoplasia of the primary teeth				
http://purl.obolibrary.org/obo/HP_0006420	obsolete Asymmetric radial dysplasia				
http://purl.obolibrary.org/obo/HP_0006436	obsolete Shortening of the tibia				
http://purl.obolibrary.org/obo/HP_0006504	obsolete Anomaly of the limb diaphyses morphology				
http://purl.obolibrary.org/obo/HP_0006525	obsolete Lung segmentation defects				
http://purl.obolibrary.org/obo/HP_0006541	obsolete Chronic obstructive airway disease from birth				
http://purl.obolibrary.org/obo/HP_0006830	obsolete Severe neonatal hypotonia in males				
http://purl.obolibrary.org/obo/HP_0006877	obsolete Mental retardation, in some				
http://purl.obolibrary.org/obo/HP_0006887	obsolete Intellectual disability, progressive				
http://purl.obolibrary.org/obo/HP_0006893	obsolete Severely dysplastic cerebellum				
http://purl.obolibrary.org/obo/HP_0006901	obsolete Impaired thermal sensitivity				
http://purl.obolibrary.org/obo/HP_0006926	obsolete Metachromatic leukodystrophy variant				
http://purl.obolibrary.org/obo/HP_0006957	obsolete Loss of ability to walk				
http://purl.obolibrary.org/obo/HP_0006983	obsolete Slowly progressive spastic quadriparesis				
http://purl.obolibrary.org/obo/HP_0006984	obsolete Distal sensory loss of all modalities				
http://purl.obolibrary.org/obo/HP_0007081	obsolete Late-onset muscular dystrophy				
http://purl.obolibrary.org/obo/HP_0007087	obsolete Involuntary jerking movements				
http://purl.obolibrary.org/obo/HP_0007095	obsolete Frontoparietal polymicrogyria				
http://purl.obolibrary.org/obo/HP_0007163	obsolete Corticospinal tract disease in lower limbs				
http://purl.obolibrary.org/obo/HP_0007227	obsolete Macrogyria				
http://purl.obolibrary.org/obo/HP_0007314	obsolete White matter neuronal heterotopia				
http://purl.obolibrary.org/obo/HP_0007316	obsolete Involuntary writhing movements				
http://purl.obolibrary.org/obo/HP_0007409	obsolete Absence of subcutaneous fat over entire body except buttocks, hips, and thighs				
http://purl.obolibrary.org/obo/HP_0007435	obsolete Diffuse palmoplantar keratoderma				
http://purl.obolibrary.org/obo/HP_0007436	obsolete Hair-nail ectodermal dysplasia				
http://purl.obolibrary.org/obo/HP_0007519	obsolete Lack of subcutaneous fatty tissue				
http://purl.obolibrary.org/obo/HP_0007543	obsolete Epidermal hyperkeratosis				
http://purl.obolibrary.org/obo/HP_0007548	obsolete Palmoplantar keratosis with erythema and scale				
http://purl.obolibrary.org/obo/HP_0007561	obsolete Telangiectases in sun-exposed and nonexposed skin				
http://purl.obolibrary.org/obo/HP_0007597	obsolete Congenital palmoplantar keratodermia				
http://purl.obolibrary.org/obo/HP_0007654	obsolete Retinal striation				
http://purl.obolibrary.org/obo/HP_0007659	obsolete Decreased retinal pigmentation with dispersion				
http://purl.obolibrary.org/obo/HP_0007680	obsolete Depigmented fundus				
http://purl.obolibrary.org/obo/HP_0007691	obsolete Short curly eyelashes				
http://purl.obolibrary.org/obo/HP_0007692	obsolete Nonnuclear polymorphic congenital cataract				
http://purl.obolibrary.org/obo/HP_0007698	obsolete Retinal pigment epithelial atrophy				
http://purl.obolibrary.org/obo/HP_0007702	obsolete Pigmentary retinal deposits				
http://purl.obolibrary.org/obo/HP_0007712	obsolete Choroidal dystrophy				
http://purl.obolibrary.org/obo/HP_0007713	obsolete Juvenile zonular cataracts				
http://purl.obolibrary.org/obo/HP_0007736	obsolete Pericentral retinal dystrophy				
http://purl.obolibrary.org/obo/HP_0007739	obsolete Mildly reduced visual acuity				
http://purl.obolibrary.org/obo/HP_0007744	obsolete Iridoretinal coloboma				
http://purl.obolibrary.org/obo/HP_0007748	obsolete Irido-fundal coloboma				
http://purl.obolibrary.org/obo/HP_0007756	obsolete Slitlike anterior chamber angles in children				
http://purl.obolibrary.org/obo/HP_0007757	obsolete Hypoplasia of choroid				
http://purl.obolibrary.org/obo/HP_0007758	obsolete Congenital visual impairment				
http://purl.obolibrary.org/obo/HP_0007770	obsolete Hypoplasia of the retina				
http://purl.obolibrary.org/obo/HP_0007782	obsolete Peripheral retinal cone degeneration				
http://purl.obolibrary.org/obo/HP_0007783	obsolete Butterfly retinal pigment epithelial dystrophy				
http://purl.obolibrary.org/obo/HP_0007786	obsolete Lacunar retinal depigmentation				
http://purl.obolibrary.org/obo/HP_0007798	obsolete Foveal dystrophy				
http://purl.obolibrary.org/obo/HP_0007801	obsolete Fishnet retinal pigmentation				
http://purl.obolibrary.org/obo/HP_0007808	obsolete Bilateral retinal coloboma				
http://purl.obolibrary.org/obo/HP_0007810	obsolete Progressive bifocal chorioretinal atrophy				
http://purl.obolibrary.org/obo/HP_0007815	Abnormal distribution of retinal arterioles and venules				
http://purl.obolibrary.org/obo/HP_0007825	obsolete Cataracts develop in second or third decade				
http://purl.obolibrary.org/obo/HP_0007829	obsolete Diffuse retinal cone degeneration				
http://purl.obolibrary.org/obo/HP_0007850	obsolete Retinal vascular proliferation				
http://purl.obolibrary.org/obo/HP_0007851	obsolete Temporal displacement of maculae				
http://purl.obolibrary.org/obo/HP_0007852	obsolete Pericentral pigmentary retinopathy				
http://purl.obolibrary.org/obo/HP_0007868	obsolete Age-related macular degeneration				
http://purl.obolibrary.org/obo/HP_0007869	obsolete Peripheral retinopathy				
http://purl.obolibrary.org/obo/HP_0007876	obsolete Juvenile cortical cataract				
http://purl.obolibrary.org/obo/HP_0007893	obsolete Progressive retinal degeneration				
http://purl.obolibrary.org/obo/HP_0007898	obsolete Exudative retinopathy				
http://purl.obolibrary.org/obo/HP_0007901	obsolete Retinal malformation				
http://purl.obolibrary.org/obo/HP_0007910	obsolete Nonprogressive congenital retinal dystrophy				
http://purl.obolibrary.org/obo/HP_0007916	obsolete Small anterior lens surface opacities				
http://purl.obolibrary.org/obo/HP_0007920	obsolete Congenital chorioretinal dystrophy				
http://purl.obolibrary.org/obo/HP_0007923	obsolete Foveal hyperplasia				
http://purl.obolibrary.org/obo/HP_0007930	obsolete Prominent epicanthal folds				
http://purl.obolibrary.org/obo/HP_0007945	obsolete Choroidal degeneration				
http://purl.obolibrary.org/obo/HP_0007949	obsolete Progressive macular scarring				
http://purl.obolibrary.org/obo/HP_0007956	obsolete Bilateral choroid coloboma				
http://purl.obolibrary.org/obo/HP_0007961	obsolete Rarefaction of retinal pigmentation				
http://purl.obolibrary.org/obo/HP_0007981	obsolete Concentric narrowing of visual field				
http://purl.obolibrary.org/obo/HP_0007982	obsolete Central tapetoretinal dystrophy				
http://purl.obolibrary.org/obo/HP_0008005	obsolete Congenital corneal dystrophy				
http://purl.obolibrary.org/obo/HP_0008008	obsolete Progressive central visual loss				
http://purl.obolibrary.org/obo/HP_0008012	obsolete Congenital myopia				
http://purl.obolibrary.org/obo/HP_0008014	obsolete Central fundal arteriolar microaneurysms				
http://purl.obolibrary.org/obo/HP_0008017	obsolete Depigmented lesions of the retinal pigment epithelium				
http://purl.obolibrary.org/obo/HP_0008024	obsolete Congenital nuclear cataract				
http://purl.obolibrary.org/obo/HP_0008033	obsolete Congenital exotropia				
http://purl.obolibrary.org/obo/HP_0008035	obsolete Retinitis pigmentosa inversa				
http://purl.obolibrary.org/obo/HP_0008036	obsolete Rod-cone dystrophy				
http://purl.obolibrary.org/obo/HP_0008075	obsolete Progressive pes cavus				
http://purl.obolibrary.org/obo/HP_0008165	obsolete Decreased helper T cell proportion				
http://purl.obolibrary.org/obo/HP_0008230	obsolete Decreased testosterone in males				
http://purl.obolibrary.org/obo/HP_0008250	obsolete Infantile hypercalcemia				
http://purl.obolibrary.org/obo/HP_0008335	obsolete Renal aminoaciduria				
http://purl.obolibrary.org/obo/HP_0008356	obsolete Combined hyperlipidemia				
http://purl.obolibrary.org/obo/HP_0008498	obsolete No permanent dentition				
http://purl.obolibrary.org/obo/HP_0008501	obsolete Median cleft lip and palate				
http://purl.obolibrary.org/obo/HP_0008572	obsolete External ear malformation				
http://purl.obolibrary.org/obo/HP_0008636	obsolete Lobular glomerulopathy				
http://purl.obolibrary.org/obo/HP_0008648	obsolete Anteriorly displaced urethral meatus				
http://purl.obolibrary.org/obo/HP_0008694	obsolete Hypertrophic labia minora				
http://purl.obolibrary.org/obo/HP_0008715	obsolete Testicular dysgenesis				
http://purl.obolibrary.org/obo/HP_0008803	obsolete Narrow sacroiliac notch				
http://purl.obolibrary.org/obo/HP_0008826	obsolete Dislocation of the femoral head				
http://purl.obolibrary.org/obo/HP_0009042	obsolete Marked muscular hypertrophy				
http://purl.obolibrary.org/obo/HP_0009044	obsolete Hypoplasia of deltoid muscle				
http://purl.obolibrary.org/obo/HP_0009062	obsolete Infantile axial hypotonia				
http://purl.obolibrary.org/obo/HP_0009090	obsolete Facial diplegic appearance				
http://purl.obolibrary.org/obo/HP_0009163	obsolete Abnormal form of the 5th finger				
http://purl.obolibrary.org/obo/HP_0009178	obsolete Symphalangism of middle phalanx of 5th finger				
http://purl.obolibrary.org/obo/HP_0009232	obsolete Symphalangism affecting the proximal phalanx of the 5th finger				
http://purl.obolibrary.org/obo/HP_0009308	obsolete Symphalangism of middle phalanx of 4th finger				
http://purl.obolibrary.org/obo/HP_0009314	obsolete Symphalangism affecting the proximal phalanx of the 4th finger				
http://purl.obolibrary.org/obo/HP_0009435	obsolete Symphalangism of middle phalanx of 3rd finger				
http://purl.obolibrary.org/obo/HP_0009448	obsolete Aplasia of the phalanges of the 3rd finger				
http://purl.obolibrary.org/obo/HP_0009449	obsolete Hypoplastic/small phalanges of the 3rd finger				
http://purl.obolibrary.org/obo/HP_0009455	obsolete Symphalangism affecting the proximal phalanx of the 3rd finger				
http://purl.obolibrary.org/obo/HP_0009574	obsolete Symphalangism of middle phalanx of 2nd finger				
http://purl.obolibrary.org/obo/HP_0009586	obsolete Symphalangism affecting the proximal phalanx of the 2nd finger				
http://purl.obolibrary.org/obo/HP_0009595	obsolete Occasional neurofibromas				
http://purl.obolibrary.org/obo/HP_0009620	obsolete Radial deviation of the thumb				
http://purl.obolibrary.org/obo/HP_0009621	obsolete Ulnar deviation of the thumb				
http://purl.obolibrary.org/obo/HP_0009822	obsolete Aplasia involving forearm bones				
http://purl.obolibrary.org/obo/HP_0009849	obsolete Symphalangism of middle phalanx of finger				
http://purl.obolibrary.org/obo/HP_0009857	obsolete Symphalangism affecting the proximal phalanges of the hand				
http://purl.obolibrary.org/obo/HP_0009885	obsolete Prenatal short stature				
http://purl.obolibrary.org/obo/HP_0010064	obsolete Symphalangism affecting the phalanges of the hallux				
http://purl.obolibrary.org/obo/HP_0010082	obsolete Symphalangism affecting the distal phalanx of the hallux				
http://purl.obolibrary.org/obo/HP_0010191	obsolete Symphalangism affecting the distal phalanges of the toes				
http://purl.obolibrary.org/obo/HP_0010209	obsolete Symphalangism affecting the proximal phalanges of the toes				
http://purl.obolibrary.org/obo/HP_0010221	obsolete Pseudoepiphysis of the 2nd metacarpal				
http://purl.obolibrary.org/obo/HP_0010410	obsolete Symphalangism affecting the middle phalanx of the 2nd toe				
http://purl.obolibrary.org/obo/HP_0010457	obsolete Widening of the sacrosciatic notch				
http://purl.obolibrary.org/obo/HP_0010692	obsolete 2-5 finger syndactyly				
http://purl.obolibrary.org/obo/HP_0010700	obsolete Total cataract				
http://purl.obolibrary.org/obo/HP_0010960	obsolete Bronchopulmonary sequestration				
http://purl.obolibrary.org/obo/HP_0010961	obsolete Intralobar sequestration				
http://purl.obolibrary.org/obo/HP_0010962	obsolete Extralobar sequestration				
http://purl.obolibrary.org/obo/HP_0011148	obsolete Absence seizures with special features				
http://purl.obolibrary.org/obo/HP_0011155	obsolete Focal autonomic seizures with altered responsiveness				
http://purl.obolibrary.org/obo/HP_0011156	obsolete Focal autonomic seizures without altered responsiveness				
http://purl.obolibrary.org/obo/HP_0011162	obsolete Psychic auras				
http://purl.obolibrary.org/obo/HP_0011164	obsolete Vegetative auras				
http://purl.obolibrary.org/obo/HP_0011349	obsolete Abducens palsy				
http://purl.obolibrary.org/obo/HP_0011357	obsolete Abnormality of hair density				
http://purl.obolibrary.org/obo/HP_0011398	obsolete Central hypotonia				
http://purl.obolibrary.org/obo/HP_0011498	obsolete Partial aniridia				
http://purl.obolibrary.org/obo/HP_0011605	obsolete Congenitally corrected transposition of the great arteries with ventricular septal defect				
http://purl.obolibrary.org/obo/HP_0011606	obsolete Transposition of the great arteries with intact ventricular septum				
http://purl.obolibrary.org/obo/HP_0011607	obsolete Transposition of the great arteries with ventricular septal defect				
http://purl.obolibrary.org/obo/HP_0011765	obsolete Ectopic anterior pituitary				
http://purl.obolibrary.org/obo/HP_0011837	obsolete Partial IgA deficiency				
http://purl.obolibrary.org/obo/HP_0012178	obsolete Reduced natural killer cell activity				
http://purl.obolibrary.org/obo/HP_0012201	obsolete Reduced prothrombin activity				
http://purl.obolibrary.org/obo/HP_0012290	obsolete Mouth neoplasm				
http://purl.obolibrary.org/obo/HP_0012291	obsolete Tracheal neoplasm				
http://purl.obolibrary.org/obo/HP_0012335	obsolete Abnormality of folate metabolism				
http://purl.obolibrary.org/obo/HP_0012336	obsolete Reduced cerebrospinal fluid 5-methyltetrahydrofolate concentration				
http://purl.obolibrary.org/obo/HP_0012455	obsolete Large artery calcification				
http://purl.obolibrary.org/obo/HP_0012509	obsolete Reduced thyroxin-binding globulin				
http://purl.obolibrary.org/obo/HP_0012611	obsolete Increased urinary urate				
http://purl.obolibrary.org/obo/HP_0012677	obsolete Iron accumulation in globus pallidus				
http://purl.obolibrary.org/obo/HP_0100237	obsolete Proximal foot symphalangism				
http://purl.obolibrary.org/obo/HP_0100470	obsolete Symphalangism affecting the middle phalanx of the 3rd toe				
http://purl.obolibrary.org/obo/HP_0100471	obsolete Symphalangism affecting the middle phalanx of the 4th toe				
http://purl.obolibrary.org/obo/HP_0100472	obsolete Symphalangism affecting the middle phalanx of the 5th toe				
http://purl.obolibrary.org/obo/HP_0100473	obsolete Symphalangism affecting the proximal phalanx of the 3rd toe				
http://purl.obolibrary.org/obo/HP_0100474	obsolete Symphalangism affecting the proximal phalanx of the 4th toe				
http://purl.obolibrary.org/obo/HP_0100475	obsolete Symphalangism affecting the proximal phalanx of the 5th toe				
http://purl.obolibrary.org/obo/HP_0100489	obsolete Proximal/middle symphalangism of 2nd toe				
http://purl.obolibrary.org/obo/HP_0100609	obsolete Hypermenorrhea				
http://purl.obolibrary.org/obo/HP_0100637	obsolete Neoplasia of the nose				
http://purl.obolibrary.org/obo/HP_0100672	obsolete Vaginal hernia				
http://purl.obolibrary.org/obo/HP_0100805	obsolete Precocious menopause				
http://purl.obolibrary.org/obo/HP_0100843	obsolete Glioblastoma				
http://purl.obolibrary.org/obo/HP_0200065	obsolete Chorioretinal degeneration				
http://purl.obolibrary.org/obo/HP_0200095	obsolete Anterior open bite				
http://purl.obolibrary.org/obo/HP_0200099	obsolete Peripheral retinal pigmentation abnormalities				
http://purl.obolibrary.org/obo/HP_0200126	obsolete Amyloid cardiomyopathy				
http://purl.obolibrary.org/obo/HP_0200129	obsolete Calcific mitral stenosis				
http://purl.obolibrary.org/obo/HP_0200135	obsolete Macrocephaly due to hydrocephalus				
http://purl.obolibrary.org/obo/HP_0200144	obsolete Anaphylactoid purpura				
http://purl.obolibrary.org/obo/HP_0030266	obsolete Abnormality of the sacroiliac notch				
http://purl.obolibrary.org/obo/HP_0040065	obsolete Abnormal morphology of bones of the upper limbs				
http://purl.obolibrary.org/obo/HP_0040066	obsolete Abnormal morphology of bones of the lower limbs				
http://purl.obolibrary.org/obo/HP_0040073	obsolete Abnormal forearm bone morphology				
http://purl.obolibrary.org/obo/HP_0040077	obsolete Abnormal concentration of calcium in blood				
http://purl.obolibrary.org/obo/HP_0040215	obsolete Abnormal circulating insulin level				
http://purl.obolibrary.org/obo/HP_0045009	obsolete Abnormal morphology of the radius				
http://purl.obolibrary.org/obo/HP_0410004	obsolete Cleft secondary palate				
http://purl.obolibrary.org/obo/HP_0500263	obsolete Abnormal helper T cell proportion				
http://purl.obolibrary.org/obo/HP_5200275	obsolete Abnormal motivation				
http://purl.obolibrary.org/obo/HP_6001156	obsolete Synovial crystals				
http://purl.obolibrary.org/obo/HP_0032529	obsolete Elevated circulating gamma-aminobutyric acid concentration				
http://purl.obolibrary.org/obo/HP_5200103	obsolete Reduced social responsiveness				
http://purl.obolibrary.org/obo/HP_5200122	obsolete Difficulty communicating emotions				
http://purl.obolibrary.org/obo/HP_5200128	obsolete Deficit applying language skills across context				
http://purl.obolibrary.org/obo/HP_5200131	obsolete Reduced use of language for social purposes				
http://purl.obolibrary.org/obo/HP_5200137	obsolete Infrequent social engagement with peers				
http://purl.obolibrary.org/obo/HP_6000178	obsolete Purulent drainage from Stensen duct				
http://purl.obolibrary.org/obo/HP_0025767	obsolete Abnormal positive emotional state				
http://purl.obolibrary.org/obo/HP_0025768	obsolete Inappropriate elation				
http://purl.obolibrary.org/obo/HP_0025319	obsolete Rubeosis iridis				
http://purl.obolibrary.org/obo/HP_0025356	obsolete Psychomotor retardation				
http://purl.obolibrary.org/obo/HP_0045083	obsolete Increased body mass index				
http://purl.obolibrary.org/obo/HP_0031440	obsolete Abnormal tricuspid valve morphology				
http://purl.obolibrary.org/obo/HP_0031477	obsolete Abnormal mitral valve morphology				
http://purl.obolibrary.org/obo/HP_5200269	obsolete Abnormal thought pattern				
http://purl.obolibrary.org/obo/HP_0410325	obsolete House dust mite allergy				
http://purl.obolibrary.org/obo/HP_0410381	obsolete Abnormal proportion of central memory CD4-positive T cells				
http://purl.obolibrary.org/obo/HP_0410382	obsolete Abnormal proportion of effector memory CD4-positive, alpha-beta T cells				
http://purl.obolibrary.org/obo/HP_0410387	obsolete Decreased proportion of effector memory CD4-positive, alpha-beta T cells				
http://purl.obolibrary.org/obo/HP_0410394	obsolete Increased effector memory CD4-positive T cell proportion				
http://purl.obolibrary.org/obo/HP_0033276	obsolete Glomerular endocapillary hypercellularity				
http://purl.obolibrary.org/obo/HP_0033304	obsolete Elevated urine 4-hydroxyphenylacetic acid level				
http://purl.obolibrary.org/obo/HP_6000276	obsolete Elevated urinary beta-alanine level				
http://purl.obolibrary.org/obo/HP_0025806	obsolete Abnormal total B cell count				
http://purl.obolibrary.org/obo/HP_0025121	obsolete Simple partial occipital seizures				
http://purl.obolibrary.org/obo/HP_0025191	obsolete Segmental myoclonic seizures				
http://purl.obolibrary.org/obo/HP_0025237	obsolete Confusional arousal				
http://purl.obolibrary.org/obo/HP_0025239	obsolete Subhyaloid hemorrhage				
http://purl.obolibrary.org/obo/HP_0025266	obsolete Cervical osteoarthritis				
http://purl.obolibrary.org/obo/HP_0030013	obsolete Endometriosis				
http://purl.obolibrary.org/obo/HP_0030050	obsolete Narcolepsy				
http://purl.obolibrary.org/obo/HP_0030073	obsolete Pharyngeal neoplasm				
http://purl.obolibrary.org/obo/HP_0030152	obsolete Biliary tract neoplasm				
http://purl.obolibrary.org/obo/HP_0030214	obsolete Hypersexuality				
http://purl.obolibrary.org/obo/HP_0030220	obsolete Socially inappropriate behavior				
http://purl.obolibrary.org/obo/HP_0030251	obsolete Absence of memory B cells				
http://purl.obolibrary.org/obo/HP_0030253	obsolete Defective T cell proliferation				
http://purl.obolibrary.org/obo/HP_0030276	obsolete Small scrotum				
http://purl.obolibrary.org/obo/HP_0030333	obsolete Abnormal alpha-beta T cell morphology				
http://purl.obolibrary.org/obo/HP_0030334	obsolete Abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology				
http://purl.obolibrary.org/obo/HP_0030335	obsolete Abnormal CD4-positive, CD25-positive regulatory T cell count				
http://purl.obolibrary.org/obo/HP_0030336	obsolete Absence of CD4-positive, CD25-positive regulatory T cells				
http://purl.obolibrary.org/obo/HP_0030337	obsolete Elevated CD4-positive, CD25-positive regulatory T cell count				
http://purl.obolibrary.org/obo/HP_0030340	obsolete Increased circulating gonadotropin level				
http://purl.obolibrary.org/obo/HP_0030354	obsolete Abnormal circulating interferon concentration				
http://purl.obolibrary.org/obo/HP_0030422	obsolete Papillary cystadenoma of the epididymis				
http://purl.obolibrary.org/obo/HP_0030494	obsolete Macular microaneurysm/hemorrhage				
http://purl.obolibrary.org/obo/HP_0030508	obsolete Retinal cavernous hemangioma				
http://purl.obolibrary.org/obo/HP_0030523	obsolete Peripheral visual field constriction with 40-50 degrees central field preserved				
http://purl.obolibrary.org/obo/HP_0030524	obsolete Peripheral visual field constriction with 30-39 degrees central field preserved				
http://purl.obolibrary.org/obo/HP_0030635	obsolete Retinal dystrophy with early macular involvement				
http://purl.obolibrary.org/obo/HP_0030638	obsolete Congenital stationary night blindness with normal fundus				
http://purl.obolibrary.org/obo/HP_0030639	obsolete Congenital stationary night blindness with abnormal fundus				
http://purl.obolibrary.org/obo/HP_0030640	obsolete Complete congenital stationary night blindness				
http://purl.obolibrary.org/obo/HP_0030641	obsolete Incomplete congenital stationary night blindness				
http://purl.obolibrary.org/obo/HP_0030761	obsolete Renal glomerular fibrosis				
http://purl.obolibrary.org/obo/HP_0030782	obsolete Abnormal circulating interleukin concentration				
http://purl.obolibrary.org/obo/HP_0040021	obsolete Radial deviation of the thumb				
http://purl.obolibrary.org/obo/HP_0040037	obsolete Thin fingernail (obsolete)				
http://purl.obolibrary.org/obo/HP_0040038	obsolete Thin toenail				
http://purl.obolibrary.org/obo/HP_0040110	obsolete Abnormal saccule morphology				
http://purl.obolibrary.org/obo/HP_0040111	obsolete Bilateral external ear deformity				
http://purl.obolibrary.org/obo/HP_0040124	obsolete Patent tuba eustachii				
http://purl.obolibrary.org/obo/HP_0040126	obsolete Abnormal circulating vitamin B12 concentration				
http://purl.obolibrary.org/obo/HP_0040166	obsolete Abnormality of the periosteum				
http://purl.obolibrary.org/obo/HP_0040168	obsolete Focal seizures, afebril				
http://purl.obolibrary.org/obo/HP_0040180	obsolete Hyperkeratosis pilaris				
http://purl.obolibrary.org/obo/HP_0040193	obsolete Pinealoblastoma				
http://purl.obolibrary.org/obo/HP_0040199	obsolete Flat midface				
http://purl.obolibrary.org/obo/HP_0040263	obsolete Jaw ankylosis				
http://purl.obolibrary.org/obo/HP_0040268	obsolete Recurrent infections of the middle ear				
http://purl.obolibrary.org/obo/HP_0040278	obsolete Prolactinoma				
http://purl.obolibrary.org/obo/HP_0045013	obsolete Decreased urinary glucose concentration				
http://purl.obolibrary.org/obo/HP_0045016	obsolete Elevated serum long-chain fatty acids				
http://purl.obolibrary.org/obo/HP_0045080	obsolete Decreased CD3+ T cell proportion				
http://purl.obolibrary.org/obo/HP_0410003	obsolete Cleft maxillary alveolus				
http://purl.obolibrary.org/obo/HP_0410007	obsolete Abnormality of cartilage morphology				
http://purl.obolibrary.org/obo/HP_0430026	obsolete Abnormality of the shape of the midface				
http://purl.obolibrary.org/obo/HP_3000001	obsolete Abnormal heart morphology				
http://purl.obolibrary.org/obo/HP_3000026	obsolete Abnormality of common carotid artery plus branches				
http://purl.obolibrary.org/obo/HP_0032172	obsolete Air crescent sign				
http://purl.obolibrary.org/obo/HP_0032207	obsolete Abnormal cerebrospinal fluid metabolite concentration				
http://purl.obolibrary.org/obo/HP_0032272	obsolete Elevated urinary N-acetylaspartic acid level				
http://purl.obolibrary.org/obo/HP_0041053	obsolete Fractured head				
http://purl.obolibrary.org/obo/HP_0041054	obsolete Fractured thoracic segment of trunk				
http://purl.obolibrary.org/obo/HP_0041060	obsolete Chronic partially decreased circulating IgG4				
http://purl.obolibrary.org/obo/HP_0041064	obsolete Fractured knee				
http://purl.obolibrary.org/obo/HP_0041066	obsolete Chronic partially decreased circulating IgG2				
http://purl.obolibrary.org/obo/HP_0041070	obsolete Chronic partially decreased circulating IgG1				
http://purl.obolibrary.org/obo/HP_0041075	obsolete Chronic partially decreased circulating IgG3				
http://purl.obolibrary.org/obo/HP_0041154	obsolete Fractured elbow joint				
http://purl.obolibrary.org/obo/HP_0041158	obsolete Fractured trunk				
http://purl.obolibrary.org/obo/HP_0041232	obsolete Fractured skeleton of manual acropodium				
http://purl.obolibrary.org/obo/HP_4000080	obsolete 4000080				
http://purl.obolibrary.org/obo/HP_0025568	obsolete Abnormal morphology of the choroidal vasculature				
http://purl.obolibrary.org/obo/HP_0031900	obsolete Abnormal serum tryptase concentration				
http://purl.obolibrary.org/obo/HP_0031902	obsolete Decreased serum mast cell beta-tryptase concentration				
http://purl.obolibrary.org/obo/HP_0031906	obsolete Decreased total hemolytic complement activity				
http://purl.obolibrary.org/obo/HP_0410158	obsolete Increased urine O-phosphoethanolamine level				
http://purl.obolibrary.org/obo/HP_0410177	obsolete Abnormal glucose-6-phosphate dehydrogenase level in blood				
http://purl.obolibrary.org/obo/HP_0410192	obsolete Abnormal uridine diphosphate glucose-4-epimerase level				
http://purl.obolibrary.org/obo/HP_0500088	obsolete Foveal depigmentation				
http://purl.obolibrary.org/obo/HP_0034286	obsolete Pneumocystis carinii pneumonia				
http://purl.obolibrary.org/obo/HP_0033659	obsolete Crazy-paving pattern				
http://purl.obolibrary.org/obo/HP_0040290	obsolete Abnormality of skeletal muscles				
http://purl.obolibrary.org/obo/HP_0025428	obsolete Bronchospasm				
http://purl.obolibrary.org/obo/HP_0025462	obsolete Abnormal cellular physiology				
http://purl.obolibrary.org/obo/HP_0025541	obsolete Decreased activity of complement receptor				
http://purl.obolibrary.org/obo/HP_0030995	obsolete Peritoneal effusion				
http://purl.obolibrary.org/obo/HP_0031005	obsolete Hyperalgesia				
http://purl.obolibrary.org/obo/HP_0031014	obsolete Arteria lusoria				
http://purl.obolibrary.org/obo/HP_0031068	obsolete Increased femoral torsion				
http://purl.obolibrary.org/obo/HP_0031070	obsolete Femoral retroversion				
http://purl.obolibrary.org/obo/HP_0410032	obsolete Cleft of uvula				
http://purl.obolibrary.org/obo/HP_0500010	obsolete Increased cholesterol esters				
http://purl.obolibrary.org/obo/HP_0500014	obsolete Abnormal test result				
http://purl.obolibrary.org/obo/HP_0410049	obsolete Abnormal radial ray morphology				
http://purl.obolibrary.org/obo/HP_0032683	obsolete Focal aware cognitive seizure with impaired attention				
http://purl.obolibrary.org/obo/HP_0032695	obsolete Illusory auras				
http://purl.obolibrary.org/obo/HP_0032703	obsolete Hallucinatory aura				
http://purl.obolibrary.org/obo/HP_0032875	obsolete Focal impaired awareness cognitive seizure with impaired responsiveness				
http://purl.obolibrary.org/obo/HP_0032881	obsolete Focal aware cognitive seizure with impaired responsiveness				
http://purl.obolibrary.org/obo/HP_0032931	obsolete Focal impaired awareness cognitive seizure with impaired attention				
http://purl.obolibrary.org/obo/HP_0031804	obsolete Premacular hemorrhage				
http://purl.obolibrary.org/obo/HP_0410068	obsolete Increased level of L-glutamic acid in blood				
http://purl.obolibrary.org/obo/HP_0032117	obsolete Macrosaccadic oscillation				
http://purl.obolibrary.org/obo/HP_0032119	obsolete Narrow angle glaucoma				
http://purl.obolibrary.org/obo/HP_0032982	obsolete Intraalveolar phospholipid accumulation				
http://purl.obolibrary.org/obo/HP_0033029	obsolete Anti-Jo-1 antibody positivity				
http://purl.obolibrary.org/obo/HP_0500264	obsolete Increased helper T cell proportion				
http://purl.obolibrary.org/obo/HP_0500272	obsolete Abnormal immature gamma-delta T cell proportion				
http://purl.obolibrary.org/obo/HP_0500273	obsolete Increased proportion of immature gamma-delta T cells				
http://purl.obolibrary.org/obo/HP_0500274	obsolete Decreased proportion of immature gamma-delta T cells				
http://purl.obolibrary.org/obo/HP_6001288	obsolete Reduced circulating ADAMTS13 activity				
http://purl.obolibrary.org/obo/HP_0020063	obsolete Increased hemoglobin concentration				
http://purl.obolibrary.org/obo/HP_0020098	obsolete Herpes encephalitis				
http://purl.obolibrary.org/obo/HP_0025620	obsolete Abnormal CD4+ central memory T cell proportion				
http://purl.obolibrary.org/obo/HP_0025621	obsolete Increased proportion of CD4+ central memory cells				
http://purl.obolibrary.org/obo/HP_0025622	obsolete Decreased proportion of CD4+ central memory cells				
http://purl.obolibrary.org/obo/HP_0025623	obsolete Abnormal CD4+ effector memory T cell proportion				
http://purl.obolibrary.org/obo/HP_0025632	obsolete Reduced reactive oxygen species production in neutrophils				
http://purl.obolibrary.org/obo/HP_0032364	obsolete Abnormal CSF amino acid level				
http://purl.obolibrary.org/obo/HP_0032461	obsolete Tiger-tail banding				
http://purl.obolibrary.org/obo/HP_0032483	obsolete Abnormal fecal test result				
http://purl.obolibrary.org/obo/HP_0033452	obsolete Decreased circulating prealbumin concentration				
http://purl.obolibrary.org/obo/HP_0033463	obsolete Elevated circulating palmitoleylcarnitine concentration				
http://purl.obolibrary.org/obo/HP_0025658	obsolete Abnormal umbilical artery Doppler pattern in pregnancy				
http://purl.obolibrary.org/obo/HP_0034116	obsolete Anti-thyrotropin receptor antibody				
http://purl.obolibrary.org/obo/HP_6000909	obsolete Positive stool Cryptosporidium antigen test				
http://purl.obolibrary.org/obo/HP_6001030	obsolete Peripheral nerve metachromasia				
http://purl.obolibrary.org/obo/HP_0032340	obsolete Abnormal spirometry test				
http://purl.obolibrary.org/obo/HP_0034603	obsolete Elevated circulating CA19-9 concentration				
http://purl.obolibrary.org/obo/HP_5200004	obsolete Reduced response to another's attempt to get direct attention				
http://purl.obolibrary.org/obo/HP_5200025	obsolete Abnormal social awareness				
http://purl.obolibrary.org/obo/HP_5200031	obsolete Deferred imitation of others				
http://purl.obolibrary.org/obo/HP_5200032	obsolete Reduced immediate imitation of others				
http://purl.obolibrary.org/obo/HP_5200036	obsolete Reduced responsiveness to verbal cues				
http://purl.obolibrary.org/obo/HP_5200053	obsolete Reduced nonverbal responsiveness to verbal cues				
http://purl.obolibrary.org/obo/HP_5200054	obsolete Reduced verbal responsiveness to verbal cues				
http://purl.obolibrary.org/obo/RO_0002100	has soma location	http://purl.obolibrary.org/obo/RO_0002131	overlaps		Relation between a neuron and a material anatomical entity that its soma is part of.
http://purl.obolibrary.org/obo/RO_0002258	developmentally preceded by	http://purl.obolibrary.org/obo/RO_0002324	developmentally related to		Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
http://purl.obolibrary.org/obo/RO_0002234	has output	http://purl.obolibrary.org/obo/RO_0000057	has participant		p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.
http://purl.obolibrary.org/obo/RO_0002286	developmentally succeeded by	http://purl.obolibrary.org/obo/RO_0002384	has developmental potential involving		Inverse of developmentally preceded by
http://purl.obolibrary.org/obo/RO_0002371	attached to	http://purl.obolibrary.org/obo/RO_0002177	attached to part of		a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a
http://purl.obolibrary.org/obo/RO_0002384	has developmental potential involving	http://purl.obolibrary.org/obo/RO_0002324	developmentally related to		x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
http://purl.obolibrary.org/obo/RO_0002388	has potential to directly develop into	http://purl.obolibrary.org/obo/RO_0002387	has potential to develop into		x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
http://purl.obolibrary.org/obo/RO_0002178	supplies	http://purl.obolibrary.org/obo/RO_0002170	connected to		Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy.
http://purl.obolibrary.org/obo/RO_0002372	has muscle origin	http://purl.obolibrary.org/obo/RO_0002567	biomechanically related to		m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
http://purl.obolibrary.org/obo/RO_0002374	derived from ancestral fusion of	http://purl.obolibrary.org/obo/RO_0002156	derived by descent from		x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat
http://purl.obolibrary.org/obo/RO_0002380	branching part of	http://purl.obolibrary.org/obo/RO_0002375	in branching relationship with		x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y
http://purl.obolibrary.org/obo/RO_0002568	has muscle antagonist	http://purl.obolibrary.org/obo/RO_0002567	biomechanically related to		m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position.
http://purl.obolibrary.org/obo/RO_0002569	has branching part	http://purl.obolibrary.org/obo/RO_0002375	in branching relationship with		inverse of branching part of
http://purl.obolibrary.org/obo/RO_0002571	lumen of	http://purl.obolibrary.org/obo/BFO_0000050	part of		x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to	anteriorly connected to	http://purl.obolibrary.org/obo/RO_0002170	connected to		x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.
http://purl.obolibrary.org/obo/uberon/core#distally_connected_to	distally connected to	http://purl.obolibrary.org/obo/RO_0002170	connected to		x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.
http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to	posteriorly connected to	http://purl.obolibrary.org/obo/RO_0002170	connected to		x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.
http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to	proximally connected to	http://purl.obolibrary.org/obo/RO_0002170	connected to		x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.
http://purl.obolibrary.org/obo/BFO_0000063	precedes	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/RO_0000052	characteristic of	http://purl.obolibrary.org/obo/RO_0002314	characteristic of part of		a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
http://purl.obolibrary.org/obo/RO_0000080	quality of	http://purl.obolibrary.org/obo/RO_0000052	characteristic of		a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence
http://purl.obolibrary.org/obo/RO_0000086	has quality	http://purl.obolibrary.org/obo/RO_0000053	has characteristic		a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
http://purl.obolibrary.org/obo/RO_0002000	2D boundary of	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity
http://purl.obolibrary.org/obo/RO_0002002	has 2D boundary	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
http://purl.obolibrary.org/obo/RO_0002219	surrounded by	http://purl.obolibrary.org/obo/RO_0002220	adjacent to		x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
http://purl.obolibrary.org/obo/RO_0002220	adjacent to	http://purl.obolibrary.org/obo/RO_0002163	spatially disjoint from		x adjacent to y if and only if x and y share a boundary.
http://purl.obolibrary.org/obo/RO_0002223	starts	http://purl.obolibrary.org/obo/BFO_0000050	part of		inverse of starts with
http://purl.obolibrary.org/obo/RO_0002350	member of	http://purl.obolibrary.org/obo/BFO_0000050	part of		is member of is a mereological relation between a item and a collection.
http://purl.obolibrary.org/obo/RO_0002351	has member	http://purl.obolibrary.org/obo/BFO_0000051	has part		has member is a mereological relation between a collection and an item.
http://purl.obolibrary.org/obo/RO_0002202	develops from	http://purl.obolibrary.org/obo/RO_0002254	has developmental contribution from		x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
http://purl.obolibrary.org/obo/BFO_0000051	has part	http://purl.obolibrary.org/obo/RO_0002131	overlaps		a core relation that holds between a whole and its part
http://purl.obolibrary.org/obo/RO_0000087	has role	http://purl.obolibrary.org/obo/RO_0000053	has characteristic		a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
http://purl.obolibrary.org/obo/RO_0002176	connects	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system.
http://purl.obolibrary.org/obo/RO_0002491	existence starts and ends during	http://purl.obolibrary.org/obo/RO_0002492	existence ends during		x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)
http://purl.obolibrary.org/obo/RO_0002404	causally downstream of	http://purl.obolibrary.org/obo/RO_0002427	causally downstream of or within		inverse of upstream of
http://purl.obolibrary.org/obo/RO_0002490	existence overlaps	http://purl.obolibrary.org/obo/RO_0002487	relation between physical entity and a process or stage		x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))
http://purl.obolibrary.org/obo/RO_0002252	connecting branch of	http://purl.obolibrary.org/obo/RO_0002375	in branching relationship with		b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t.
http://purl.obolibrary.org/obo/RO_0002253	has connecting branch	http://purl.obolibrary.org/obo/RO_0002375	in branching relationship with		inverse of connecting branch of
http://purl.obolibrary.org/obo/RO_0002263	acts upstream of	http://purl.obolibrary.org/obo/RO_0002264	acts upstream of or within		c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.
http://purl.obolibrary.org/obo/RO_0002304	causally upstream of, positive effect	http://purl.obolibrary.org/obo/RO_0004047	causally upstream of or within, positive effect		p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q.
http://purl.obolibrary.org/obo/RO_0002305	causally upstream of, negative effect	http://purl.obolibrary.org/obo/RO_0004046	causally upstream of or within, negative effect		p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q.
http://purl.obolibrary.org/obo/RO_0020337	has constituent monomer	http://purl.obolibrary.org/obo/RO_0002180	has component		A relation that holds between a polymer and its constituent monomers. P has_constituent_monomer 'm' if and only if P has_component multiple instances of 'm' and each instance of 'm' is covalently attached to another instance of 'm'.
http://purl.obolibrary.org/obo/RO_0002131	overlaps	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		x overlaps y if and only if there exists some z such that x has part z and z part of y
http://purl.obolibrary.org/obo/RO_0002150	continuous with	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		X continuous_with Y if and only if X and Y share a fiat boundary.
http://purl.obolibrary.org/obo/RO_0002254	has developmental contribution from	http://purl.obolibrary.org/obo/RO_0002258	developmentally preceded by		x has developmental contribution from y iff x has some part z such that z develops from y
http://purl.obolibrary.org/obo/RO_0002496	existence starts during or after	http://purl.obolibrary.org/obo/RO_0002487	relation between physical entity and a process or stage		x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).
http://purl.obolibrary.org/obo/RO_0002497	existence ends during or before	http://purl.obolibrary.org/obo/RO_0002487	relation between physical entity and a process or stage		x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.
http://purl.obolibrary.org/obo/BFO_0000062	preceded by	http://purl.obolibrary.org/obo/RO_0002086	ends after		x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/RO_0002156	derived by descent from	http://purl.obolibrary.org/obo/RO_0002320	evolutionarily related to		d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a.
http://purl.obolibrary.org/obo/RO_0000081	role of	http://purl.obolibrary.org/obo/RO_0000052	characteristic of		a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
http://purl.obolibrary.org/obo/RO_0002411	causally upstream of	http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within		p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q.
http://purl.obolibrary.org/obo/RO_0018033	is deprotonated form of	http://purl.obolibrary.org/obo/RO_0018030	chemical relationship		A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B.

This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.
http://purl.obolibrary.org/obo/RO_0018034	is protonated form of	http://purl.obolibrary.org/obo/RO_0018030	chemical relationship		A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B.

This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations.
http://purl.obolibrary.org/obo/RO_0018036	is tautomer of	http://purl.obolibrary.org/obo/RO_0018030	chemical relationship		Two chemicals are tautomers if they can be readily interconverted.

This commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms.
http://purl.obolibrary.org/obo/RO_0018037	is substitutent group from	http://purl.obolibrary.org/obo/RO_0018030	chemical relationship		Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization.
http://purl.obolibrary.org/obo/RO_0018038	has functional parent	http://purl.obolibrary.org/obo/RO_0018030	chemical relationship		Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. 

For example, the relationship between a salt and a freebased compound is a "has functional parent" relationship.
http://purl.obolibrary.org/obo/RO_0018039	is enantiomer of	http://purl.obolibrary.org/obo/RO_0018030	chemical relationship		Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center.

A chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers).
http://purl.obolibrary.org/obo/RO_0018040	has parent hydride	http://purl.obolibrary.org/obo/RO_0018030	chemical relationship		Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B.
http://purl.obolibrary.org/obo/BFO_0000050	part of	http://purl.obolibrary.org/obo/RO_0002131	overlaps		a core relation that holds between a part and its whole
http://purl.obolibrary.org/obo/RO_0002211	regulates	http://purl.obolibrary.org/obo/RO_0002411	causally upstream of		p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q.
http://purl.obolibrary.org/obo/RO_0002212	negatively regulates	http://purl.obolibrary.org/obo/RO_0002211	regulates		p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q.
http://purl.obolibrary.org/obo/RO_0002213	positively regulates	http://purl.obolibrary.org/obo/RO_0002211	regulates		p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q.
http://purl.obolibrary.org/obo/RO_0002180	has component	http://purl.obolibrary.org/obo/BFO_0000051	has part		w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
http://purl.obolibrary.org/obo/RO_0002163	spatially disjoint from	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		A is spatially_disjoint_from B if and only if they have no parts in common
http://purl.obolibrary.org/obo/RO_0002314	characteristic of part of	http://purl.obolibrary.org/obo/RO_0002502	depends on		q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.
http://purl.obolibrary.org/obo/RO_0002353	output of	http://purl.obolibrary.org/obo/RO_0002328	functionally related to		inverse of has output
http://purl.obolibrary.org/obo/RO_0002473	composed primarily of	http://purl.obolibrary.org/obo/BFO_0000051	has part		x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
http://purl.obolibrary.org/obo/RO_0002104	has plasma membrane part	http://purl.obolibrary.org/obo/BFO_0000051	has part		Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
http://purl.obolibrary.org/obo/RO_0002203	develops into	http://purl.obolibrary.org/obo/RO_0002387	has potential to develop into		inverse of develops from
http://purl.obolibrary.org/obo/RO_0002215	capable of	http://purl.obolibrary.org/obo/RO_0002216	capable of part of		A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. 
http://purl.obolibrary.org/obo/RO_0002387	has potential to develop into	http://purl.obolibrary.org/obo/RO_0002384	has developmental potential involving		x has the potential to develop into y iff x develops into y or if x is capable of developing into y
http://purl.obolibrary.org/obo/RO_0015007	increased in magnitude relative to	http://purl.obolibrary.org/obo/RO_0015006	different in magnitude relative to		q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
http://purl.obolibrary.org/obo/RO_0015008	decreased in magnitude relative to	http://purl.obolibrary.org/obo/RO_0015006	different in magnitude relative to		q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
http://purl.obolibrary.org/obo/RO_0002007	bounding layer of	http://purl.obolibrary.org/obo/BFO_0000050	part of		X outer_layer_of Y iff:
. X :continuant that bearer_of some PATO:laminar
. X part_of Y
. exists Z :surface
. X has_boundary Z
. Z boundary_of Y

has_boundary: http://purl.obolibrary.org/obo/RO_0002002
boundary_of: http://purl.obolibrary.org/obo/RO_0002000
http://purl.obolibrary.org/obo/RO_0002170	connected to	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b
http://purl.obolibrary.org/obo/RO_0002177	attached to part of	http://purl.obolibrary.org/obo/RO_0002567	biomechanically related to		a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.
http://purl.obolibrary.org/obo/RO_0002179	drains	http://purl.obolibrary.org/obo/RO_0002170	connected to		Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure.
http://purl.obolibrary.org/obo/RO_0002264	acts upstream of or within	http://purl.obolibrary.org/obo/RO_0002500	causal agent in process		c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.
http://purl.obolibrary.org/obo/RO_0002375	in branching relationship with	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network.
http://purl.obolibrary.org/obo/RO_0002376	tributary of	http://purl.obolibrary.org/obo/RO_0002375	in branching relationship with		x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein.
http://purl.obolibrary.org/obo/RO_0002431	involved in or involved in regulation of	http://purl.obolibrary.org/obo/RO_0002500	causal agent in process		c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p
http://purl.obolibrary.org/obo/RO_0002503	towards	http://purl.obolibrary.org/obo/RO_0002502	depends on		q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2
http://purl.obolibrary.org/obo/RO_0002567	biomechanically related to	http://purl.obolibrary.org/obo/RO_0002328	functionally related to		A relation that holds between elements of a musculoskeletal system or its analogs.
http://purl.obolibrary.org/obo/RO_0002373	has muscle insertion	http://purl.obolibrary.org/obo/RO_0002567	biomechanically related to		m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
http://purl.obolibrary.org/obo/RO_0002433	contributes to morphology of	http://purl.obolibrary.org/obo/RO_0002131	overlaps		p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm.
http://purl.obolibrary.org/obo/RO_0002488	existence starts during	http://purl.obolibrary.org/obo/RO_0002496	existence starts during or after		x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y).
http://purl.obolibrary.org/obo/RO_0002489	existence starts with	http://purl.obolibrary.org/obo/RO_0002488	existence starts during		x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y).
http://purl.obolibrary.org/obo/RO_0002492	existence ends during	http://purl.obolibrary.org/obo/RO_0002497	existence ends during or before		x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y).
http://purl.obolibrary.org/obo/RO_0002493	existence ends with	http://purl.obolibrary.org/obo/RO_0002492	existence ends during		x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y).
http://purl.obolibrary.org/obo/RO_0002494	transformation of	http://purl.obolibrary.org/obo/RO_0002202	develops from		x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships
http://purl.obolibrary.org/obo/RO_0002495	immediate transformation of	http://purl.obolibrary.org/obo/RO_0002207	directly develops from		x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t
http://purl.obolibrary.org/obo/RO_0002551	has skeleton	http://purl.obolibrary.org/obo/BFO_0000051	has part		A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
http://purl.obolibrary.org/obo/RO_0002572	luminal space of	http://purl.obolibrary.org/obo/RO_0002571	lumen of		s is luminal space of x iff s is lumen_of x and s is an immaterial entity
http://purl.obolibrary.org/obo/RO_0002576	skeleton of	http://purl.obolibrary.org/obo/BFO_0000050	part of		inverse of has skeleton
http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into	extends_fibers_into	http://purl.obolibrary.org/obo/RO_0002170	connected to		X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y
http://purl.obolibrary.org/obo/RO_0020101	vessel supplies blood to	http://purl.obolibrary.org/obo/RO_0002178	supplies		x vessel supplies blood to y if and only if x is a vessel that supplies blood directly or indirectly to an anatomical structure y.
http://purl.obolibrary.org/obo/RO_0020102	vessel drains blood from	http://purl.obolibrary.org/obo/RO_0002179	drains		x vessel drains blood from y if and only if x is a vessel that drains blood directly or indirectly from an anatomical structure y.
http://purl.obolibrary.org/obo/RO_0002103	synapsed by	http://purl.obolibrary.org/obo/RO_0002485	receives input from		Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. 
http://purl.obolibrary.org/obo/RO_0002110	has postsynaptic terminal in	http://purl.obolibrary.org/obo/RO_0002130	has synaptic terminal in		Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. 
http://purl.obolibrary.org/obo/RO_0002113	has presynaptic terminal in	http://purl.obolibrary.org/obo/RO_0002130	has synaptic terminal in		Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input.
http://purl.obolibrary.org/obo/RO_0002120	synapsed to	http://purl.obolibrary.org/obo/RO_0002486	sends output to		 Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.
        
http://purl.obolibrary.org/obo/RO_0002130	has synaptic terminal in	http://purl.obolibrary.org/obo/RO_0002131	overlaps		A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
http://purl.obolibrary.org/obo/RO_0002216	capable of part of	http://purl.obolibrary.org/obo/RO_0002500	causal agent in process		c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
http://purl.obolibrary.org/obo/RO_0002255	developmentally contributes to	http://purl.obolibrary.org/obo/RO_0002385	has potential to developmentally contribute to		inverse of has developmental contribution from
http://purl.obolibrary.org/obo/RO_0002329	part of structure that is capable of	http://purl.obolibrary.org/obo/RO_0002328	functionally related to		this relation holds between c and p when c is part of some c', and c' is capable of p.
http://purl.obolibrary.org/obo/RO_0002334	regulated by	http://purl.obolibrary.org/obo/RO_0002427	causally downstream of or within		inverse of regulates
http://purl.obolibrary.org/obo/RO_0002335	negatively regulated by	http://purl.obolibrary.org/obo/RO_0002334	regulated by		inverse of negatively regulates
http://purl.obolibrary.org/obo/RO_0002336	positively regulated by	http://purl.obolibrary.org/obo/RO_0002334	regulated by		inverse of positively regulates
http://purl.obolibrary.org/obo/RO_0002379	spatially coextensive with	http://purl.obolibrary.org/obo/RO_0002131	overlaps		x spatially_coextensive_with y if and inly if x and y have the same location
http://purl.obolibrary.org/obo/RO_0002385	has potential to developmentally contribute to	http://purl.obolibrary.org/obo/RO_0002384	has developmental potential involving		x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within	http://purl.obolibrary.org/obo/RO_0002501	causal relation between processes		p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q.
http://purl.obolibrary.org/obo/RO_0002427	causally downstream of or within	http://purl.obolibrary.org/obo/RO_0002501	causal relation between processes		inverse of causally upstream of or within
http://purl.obolibrary.org/obo/RO_0002500	causal agent in process	http://purl.obolibrary.org/obo/RO_0002595	causal relation between material entity and a process		A relationship between a material entity and a process where the material entity has some causal role that influences the process
http://purl.obolibrary.org/obo/RO_0002501	causal relation between processes	http://purl.obolibrary.org/obo/RO_0002410	causally related to		p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q.
http://purl.obolibrary.org/obo/RO_0002584	has part structure that is capable of	http://purl.obolibrary.org/obo/RO_0002595	causal relation between material entity and a process		s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p
http://purl.obolibrary.org/obo/RO_0002595	causal relation between material entity and a process	http://purl.obolibrary.org/obo/RO_0002410	causally related to		A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
http://purl.obolibrary.org/obo/RO_0002596	capable of regulating	http://purl.obolibrary.org/obo/RO_0002500	causal agent in process		Holds between c and p if and only if c is capable of some activity a, and a regulates p.
http://purl.obolibrary.org/obo/RO_0002597	capable of negatively regulating	http://purl.obolibrary.org/obo/RO_0002596	capable of regulating		Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.
http://purl.obolibrary.org/obo/RO_0002598	capable of positively regulating	http://purl.obolibrary.org/obo/RO_0002596	capable of regulating		Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.
http://purl.obolibrary.org/obo/RO_0002608	process has causal agent	http://purl.obolibrary.org/obo/RO_0002410	causally related to		Inverse of 'causal agent in process'
http://purl.obolibrary.org/obo/RO_0002082	simultaneous with	http://purl.obolibrary.org/obo/RO_0002081	before or simultaneous with		x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
http://purl.obolibrary.org/obo/RO_0002157	has derived by descendant	http://purl.obolibrary.org/obo/RO_0002320	evolutionarily related to		inverse of derived by descent from
http://purl.obolibrary.org/obo/RO_0002158	shares ancestor with	http://purl.obolibrary.org/obo/RO_0002320	evolutionarily related to		two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a.
http://purl.obolibrary.org/obo/RO_0002206	expressed in	http://purl.obolibrary.org/obo/RO_0002330	genomically related to		x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process
http://purl.obolibrary.org/obo/RO_0002207	directly develops from	http://purl.obolibrary.org/obo/RO_0002202	develops from		Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y.
http://purl.obolibrary.org/obo/RO_0002210	directly develops into	http://purl.obolibrary.org/obo/RO_0002203	develops into		inverse of directly develops from
http://purl.obolibrary.org/obo/RO_0002221	surrounds	http://purl.obolibrary.org/obo/RO_0002220	adjacent to		inverse of surrounded by
http://purl.obolibrary.org/obo/RO_0002224	starts with	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/RO_0002225	develops from part of	http://purl.obolibrary.org/obo/RO_0002202	develops from		x develops from part of y if and only if there exists some z such that x develops from z and z is part of y
http://purl.obolibrary.org/obo/RO_0002226	develops in	http://purl.obolibrary.org/obo/RO_0002258	developmentally preceded by		x develops_in y if x is located in y whilst x is developing
http://purl.obolibrary.org/obo/RO_0002229	ends	http://purl.obolibrary.org/obo/BFO_0000050	part of		inverse of ends with
http://purl.obolibrary.org/obo/RO_0002230	ends with	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/RO_0002231	has start location	http://purl.obolibrary.org/obo/RO_0002479	has part that occurs in		x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y
http://purl.obolibrary.org/obo/RO_0002232	has end location	http://purl.obolibrary.org/obo/RO_0002479	has part that occurs in		x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y
http://purl.obolibrary.org/obo/RO_0002256	developmentally induced by	http://purl.obolibrary.org/obo/RO_0002258	developmentally preceded by		t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T
http://purl.obolibrary.org/obo/RO_0002257	developmentally induces	http://purl.obolibrary.org/obo/RO_0002386	has potential to developmentally induce		Inverse of developmentally induced by
http://purl.obolibrary.org/obo/RO_0002285	developmentally replaces	http://purl.obolibrary.org/obo/RO_0002258	developmentally preceded by		x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else
http://purl.obolibrary.org/obo/RO_0002292	expresses	http://purl.obolibrary.org/obo/RO_0002330	genomically related to		y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process.
http://purl.obolibrary.org/obo/RO_0015015	has high plasma membrane amount	http://purl.obolibrary.org/obo/RO_0002104	has plasma membrane part		A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface.
http://purl.obolibrary.org/obo/RO_0015016	has low plasma membrane amount	http://purl.obolibrary.org/obo/RO_0002104	has plasma membrane part		A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface.
http://purl.obolibrary.org/obo/RO_0002339	has target end location	http://purl.obolibrary.org/obo/RO_0002344	results in transport to from or in		This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l.
http://purl.obolibrary.org/obo/RO_0002386	has potential to developmentally induce	http://purl.obolibrary.org/obo/RO_0002384	has developmental potential involving		x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y
http://purl.obolibrary.org/obo/RO_0002428	involved in regulation of	http://purl.obolibrary.org/obo/RO_0002431	involved in or involved in regulation of		c involved in regulation of p if c is involved in some p' and p' regulates some p
http://purl.obolibrary.org/obo/RO_0002570	conduit for	http://purl.obolibrary.org/obo/RO_0002131	overlaps		x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x.
http://purl.obolibrary.org/obo/RO_0002287	part of developmental precursor of	http://purl.obolibrary.org/obo/RO_0002286	developmentally succeeded by		
http://purl.obolibrary.org/obo/RO_0002159	serially homologous to	http://purl.obolibrary.org/obo/RO_0002320	evolutionarily related to		
http://purl.obolibrary.org/obo/RO_0002090	immediately precedes	http://purl.obolibrary.org/obo/BFO_0000063	precedes		
http://purl.obolibrary.org/obo/RO_0002006	has synaptic terminal of	http://purl.obolibrary.org/obo/RO_0002131	overlaps		
http://purl.obolibrary.org/obo/RO_0002360	has dendrite location	http://purl.obolibrary.org/obo/RO_0002131	overlaps		
http://purl.obolibrary.org/obo/RO_0002087	immediately preceded by	http://purl.obolibrary.org/obo/BFO_0000062	preceded by		
http://purl.obolibrary.org/obo/RO_0002081	before or simultaneous with	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		
http://purl.obolibrary.org/obo/RO_0002086	ends after	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		
http://purl.obolibrary.org/obo/uberon/core#layer_part_of	layer part of	http://purl.obolibrary.org/obo/BFO_0000050	part of		
http://purl.obolibrary.org/obo/uberon/core#trunk_part_of	trunk_part_of	http://purl.obolibrary.org/obo/BFO_0000050	part of		
http://purl.obolibrary.org/obo/uberon/core#subdivision_of	subdivision of	http://purl.obolibrary.org/obo/BFO_0000050	part of		
http://purl.obolibrary.org/obo/RO_0002485	receives input from	http://purl.obolibrary.org/obo/RO_0002170	connected to		
http://purl.obolibrary.org/obo/RO_0002486	sends output to	http://purl.obolibrary.org/obo/RO_0002170	connected to		
http://purl.obolibrary.org/obo/RO_0004046	causally upstream of or within, negative effect	http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within		
http://purl.obolibrary.org/obo/RO_0004047	causally upstream of or within, positive effect	http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within		
http://purl.obolibrary.org/obo/uberon/core#sexually_homologous_to	sexually_homologous_to	http://purl.obolibrary.org/obo/RO_0002158	shares ancestor with		
http://purl.obolibrary.org/obo/RO_0002344	results in transport to from or in	http://purl.obolibrary.org/obo/RO_0002337	related via localization to		
http://purl.obolibrary.org/obo/uberon/core#filtered_through	filtered through				Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity.
http://purl.obolibrary.org/obo/RO_0002320	evolutionarily related to				A relationship that holds via some environmental process
http://purl.obolibrary.org/obo/RO_0002324	developmentally related to				A relationship that holds between entities participating in some developmental process (GO:0032502)
http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies	indirectly_supplies				a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s.
http://purl.obolibrary.org/obo/uberon/core#site_of	site_of				c site_of p if c is the bearer of a disposition that is realized by a process that has p as part.
http://purl.obolibrary.org/obo/BFO_0000067	contains process				[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
http://purl.obolibrary.org/obo/RO_0000053	has characteristic				Inverse of characteristic_of
http://purl.obolibrary.org/obo/RO_0000056	participates in				a relation between a continuant and a process, in which the continuant is somehow involved in the process
http://purl.obolibrary.org/obo/RO_0000057	has participant				a relation between a process and a continuant, in which the continuant is somehow involved in the process
http://purl.obolibrary.org/obo/RO_0001015	location of				a relation between two independent continuants, the location and the target, in which the target is entirely within the location
http://purl.obolibrary.org/obo/RO_0001025	located in				a relation between two independent continuants, the target and the location, in which the target is entirely within the location
http://purl.obolibrary.org/obo/RO_0003000	produces				a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.
http://purl.obolibrary.org/obo/RO_0003001	produced by				a produced_by b iff some process that occurs_in b has_output a.
http://purl.obolibrary.org/obo/RO_0002573	has modifier				A relation that holds between an attribute or a qualifier and another attribute.
http://purl.obolibrary.org/obo/RO_0015006	different in magnitude relative to				q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
http://purl.obolibrary.org/obo/BFO_0000066	occurs in				b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to				A mereological relationship or a topological relationship
http://purl.obolibrary.org/obo/RO_0002328	functionally related to				A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
http://purl.obolibrary.org/obo/RO_0015011	has cross section				s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
http://purl.obolibrary.org/obo/RO_0015012	reciprocal of				q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
http://purl.obolibrary.org/obo/RO_0020104	is neuron				This property only applies to neurons
http://purl.obolibrary.org/obo/RO_0020105	is anatomical entity				This property only applies to anatomical entities.
http://purl.obolibrary.org/obo/RO_0002330	genomically related to				holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts.
http://purl.obolibrary.org/obo/RO_0002134	innervates				Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.
T innervates some R
Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
http://purl.obolibrary.org/obo/RO_0002005	innervated by				relation between an anatomical structure and a neuron projection bundle that has synaptic terminals in the structure.
http://purl.obolibrary.org/obo/RO_0002410	causally related to				relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.
http://purl.obolibrary.org/obo/RO_0002479	has part that occurs in				p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.
http://purl.obolibrary.org/obo/RO_0002337	related via localization to				A relationship that holds via some process of localization
http://purl.obolibrary.org/obo/nbo#has_participant	has_participant				
http://purl.obolibrary.org/obo/nbo#by_means	by_means				
http://purl.obolibrary.org/obo/nbo#in_response_to	in_response_to				
http://purl.obolibrary.org/obo/uberon/core#channels_from	channels_from				
http://purl.obolibrary.org/obo/uberon/core#channels_into	channels_into				
http://purl.obolibrary.org/obo/uberon/core#in_innermost_side_of	in_innermost_side_of				
http://purl.obolibrary.org/obo/uberon/core#in_outermost_side_of	in_outermost_side_of				
http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to	transitively anteriorly connected to				
http://purl.obolibrary.org/obo/uberon/core#transitively_distally_connected_to	transitively distally connected to				
http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to	transitively proximally connected to				
http://purl.obolibrary.org/obo/RO_0002487	relation between physical entity and a process or stage				
http://purl.obolibrary.org/obo/CL_4030045	lacks_part				
http://purl.obolibrary.org/obo/RO_0002222	temporally related to				
http://purl.obolibrary.org/obo/CL_4030044	has_not_completed				
http://purl.obolibrary.org/obo/CL_4030046	lacks_plasma_membrane_part				
http://purl.obolibrary.org/obo/RO_0018030	chemical relationship				
http://purl.obolibrary.org/obo/RO_0002502	depends on				
http://purl.obolibrary.org/obo/RO_0015010	has relative magnitude				
http://purl.obolibrary.org/obo/uberon/core#channel_for	channel for				
http://purl.obolibrary.org/obo/uberon/core#protects	protects